In the United States Court of Federal Claims

OFFICE OF SPECIAL MASTERS

No. 17-0079V

(to be published)

* * * * * * * * * * * * * * * * * * * * * * * * * Chief Special Master Corcoran

LUKE CAREDIO and *

JAMIELEE CAREDIO on behalf of *

their minor daughter, D.C., *

* Filed: July 30, 2021

Petitioners, * 

*

v. *

*

SECRETARY OF HEALTH AND *

HUMAN SERVICES, *

*

Respondent. *

*

* * * * * * * * * * * * * * * * * * * * * * * * *

Michael A. Firestone, Marvin Firestone, MD, JD, & Assoc., San Mateo, CA, for Petitioners.

Terrence Mangan, U.S. Department of Justice, Washington, DC, for Respondent.

ENTITLEMENT DECISION1

On January 17, 2017, Luke and Jamielee Caredio, on behalf of their minor daughter, D.C., 

filed this action seeking compensation under the National Vaccine Injury Compensation Program 

(the “Program”). 2 ECF No. 1. The Petitioners allege that an influenza (“flu”) vaccine administered 

to D.C. on January 22, 2014, caused her to incur an autoimmune form of epilepsy, plus a number 

of secondary symptoms (anxiety and post-traumatic stress in particular). An entitlement hearing 

in the matter was held in Washington, D.C. on January 28-29, 2021.

1 This Decision will be posted on the United States Court of Federal Claims’ website in accordance with the EGovernment Act of 2002, 44 U.S.C. § 3501 (2012). This means the Decision will be available to anyone with access 

to the internet. As provided by 42 U.S.C. § 300aa-12(d)(4)(B), however, the parties may object to the published 

Ruling’s inclusion of certain kinds of confidential information. Specifically, under Vaccine Rule 18(b), each party has 

fourteen (14) days within which to request redaction “of any information furnished by that party: (1) that is a trade 

secret or commercial or financial in substance and is privileged or confidential; or (2) that includes medical files or 

similar files, the disclosure of which would constitute a clearly unwarranted invasion of privacy.” Vaccine Rule 18(b). 

Otherwise, the entire Decision will be available to the public in its current form. Id.

2 The Vaccine Program comprises Part 2 of the National Childhood Vaccine Injury Act of 1986, Pub. L. No. 99-660, 

100 Stat. 3758, codified as amended at42 U.S.C. §§ 300aa-10 through 34 (2012) [hereinafter “Vaccine Act” or “the 

Act”]. Individual section references hereafter will be to § 300aa of the Act (but will omit that statutory prefix).
2

Having reviewed the record, all expert reports and associated literature, and listened to 

those witnesses and experts who testified at the 2021 hearing, I hereby deny an entitlement award. 

As discussed in greater detail below, Petitioners have not preponderantly established that the flu 

vaccine can cause autoimmune epilepsy, or that it did so to D.C. in the relevant timeframe, with 

onset no earlier than February 2014 (and thus within 10-14 days after vaccination)—but then 

evolving over the next three months before more completely manifesting.

I. Fact History

Pre-Vaccination Health

D.C. was born on December 6, 2011, via cesarean section, and she was described as a 

“vigorous, healthy infant.” Ex. 6 at 1–3. Two months later, on February 2, 2012, Petitioners took 

D.C. to the emergency department at Memorial Hospital Los Banos because D.C. had “stopped 

breathing briefly [status post] immunizations today for approx[imately] 10 seconds.” Id. at 117. 

Petitioners ultimately left the emergency department before D.C. was evaluated by a physician, 

however. Id. at 118. Throughout 2012, D.C. was seen by pediatricians for occasionalsick visits. 

Id. at 146, 174–78, 204.

On January 6, 2013, D.C. was transported by ambulance to the Memorial Hospital Los 

Banos emergency department after she fell, hit her head, and lost consciousness for about a minute. 

Ex. 6 at 226–27, 244. She was also experiencing concurrent rhinitis and congestion. Id. at 227–28. 

D.C. was discharged, and her parents were given instructions to return if she developed symptoms 

of an acute head injury. Id. at 229. On January 13, 2013, D.C. experienced another fall, with loss 

of consciousness. Ex. 12 at 12. She was also evaluated around this same time by several physicians 

for a possible failure to thrive. Ex. 6 at 254; Ex. 7 at 132–33, 135–37. A number of laboratory 

studies were ordered to assess D.C.’s condition, but none of the findings were remarkable. Ex. 6

at 265–70. 

Vaccination and Onset of Symptoms

When she was a little more than two years old, D.C. received the flu vaccine during a visit 

with her primary pediatrician, Dr. Michael Deldin, around noon on January 22, 2014. Ex. 11 at 2; 

Ex. 6 at 277. During this visit, Dr. Deldin noted that D.C. was “doing better,” though he did not 

specify what condition had improved. Ex. 12 at 8. 

At approximately 6:00 p.m. that same day, D.C. started “shaking” while at home, but 

remained conscious and talking throughout the episode, which lasted for approximately fifteen 

minutes. Ex. 6 at 277. At 7:09 p.m., Petitioners took D.C. to the hospital, and she was admitted to 

Memorial Hospital Los Banos emergency department with a fever of 103.8 degrees. Id. at 278. 

She was discharged the same evening, and Petitioners were instructed to monitor D.C.’s condition,
3

and to administer Tylenol and ibuprofen as needed. Id. at 280. Her diagnosis at the time of 

discharge was a fever, likely related to a viral infection. Id. 

The following day, Petitioners took D.C. to the Valley Children’s Hospital Central 

California emergency department where her chief complaint was listed as a fever. Ex. 7 at 127.

She was evaluated by Soledad Raroque, M.D., who noted that D.C. “presents to the ED with fever 

and possible seizure episodes since yesterday. Patient received influenza vaccination after which 

she developed fevers. Mother reports shaking episodes with fevers yesterday. [P]atient remained 

awake and alert the whole time....Today mother reports patient having shaking episodes with 

fevers....” Id. At 3:06 p.m., D.C.’s temperature was recorded at 38.4 degrees Celsius (101.1 

degrees Fahrenheit) and 37.4 degrees Celsius (99.3 degrees Fahrenheit) at 4:10 p.m. Id. at 127–

28. Dr. Raroque’s differential diagnoses at this time included gastroenteritis, intussusception, 

Otitis Media, Tonsillitis, UTI, viral illness, and “Other (febrile seizure).” Id. at 128. Based on 

Petitioners’ description of the episode, Dr. Raroque was unable to determine whether D.C. had 

experienced a febrile seizure or simply fever-associated chills. Id. 

The next month, on February 20, 2014, D.C. returned to Dr. Deldin. Ex. 12 at 8. He noted 

that D.C. was suffering a fever and a left earache. Id. She was again seen by Dr. Deldin on February 

27, 2014 and April 21, 2014, but Dr. Deldin’s hand-written records are nearly illegible, and it is 

not clear why D.C. was seen at this time. Id. at 7–8. 

Increase in Observed Symptoms and Epilepsy Diagnosis

There is an almost three-month gap in the medical record before Petitioners again sought 

formal care for D.C. associated with the injuries alleged in this action. On May 13, 2014, D.C. was 

brought back to Dr. Deldin, who was informed that D.C. had been experiencing eye twitching, and 

also was told of a recent episode where her head rolled back. Ex. 12 at 7. Dr. Deldin recommended 

D.C. be taken to Valley Children’s Hospital for evaluation of potential seizure activity. Id. There, 

D.C.’s history of present illness was reported as a “one-week history of abnormal eye 

twitching...started having episodes [on] the right side of her face...as well as her shoulder and 

then her hand” lasting about four to five seconds without loss of consciousness. Ex. 7 at 108. D.C. 

had no fever at this time. Id. A CT scan performed that day was normal, and D.C.’s clinical 

impression remained “seizure.” Id. at 110, 112. It was recommended that D.C. be seen by her 

pediatrician the next day, and to have him schedule an outpatient electroencephalogram3 (“EEG”). 

Id. at 110. 

3 An EEG is a diagnostic test that measures the currents emanating from nerve cells in the brain. The fluctuations in 

current are shown in waves, which correlate with different neurologic conditions. Dorland’s Illustrated Medical 

Dictionary594(33rd ed. 2020)(“Dorland’s”).
4

The EEG was performed on May 21, 2014, and Dr. Andrew Mower, M.D. documented 

D.C.’s history of “episodes described as eye twitching beginning in the right then goes to the left. 

Episodes began about one month ago and occur randomly and are brief lasting...Parents also report 

in January, [D.C.] received a flu shot, [D.C.] began having stiffening and shaking of her arms 

lasting about 10 seconds. Patient appeared unresponsive and had a high temperature of 103 

degrees.” Ex. 7 at 73. The results of the EEG were abnormal, and deemed consistent with partial 

epilepsy. Id. 

D.C. was subsequently evaluated by neurologist Dr. James Nelson on May 29, 2014. Ex. 

7 at 4–6. In addition to describing D.C.’s post-vaccination episode of January 14th, Dr. Nelson’s 

history from this evaluation also noted that D.C. had fallen, stiffened, and lost consciousness on 

two separate occasions when she was a year old (but prior to receiving the vaccine at issue). Id. at 

5. Following a physical examination and review of D.C.’s medical history, Dr. Nelson diagnosed 

D.C. with partial epilepsy with impairment of consciousness, and prescribed an increased dose of 

Trileptal—an anti-epileptic medication. Id. at 6. 

On June 12, 2014, D.C. experienced an episode of right-sided eye and mouth twitching that 

lasted approximately 15-20 seconds. Ex. 7 at 33. Because this episode lasted longer than usual—

and at the recommendation of Dr. Nelson—Petitioners brought D.C. to Valley Children’s Hospital

emergency department on June 13, 2014, where she was evaluated by Michael Hauser, M.D. Id. 

He noted D.C.’s history of “having episodes of right-sided ‘twitching’ over the last few months . . 

. seem to be getting more frequent.” Id. Dr. Hauser’s physical examination of D.C. did not reveal 

any neurologic abnormalities, but he recommended D.C. be admitted for observation and EEG 

monitoring. Id. at 33–34. 

EEG video monitoring revealed left temporal parietal seizure activity. Ex. 7 at 36. D.C. 

was prescribed Topamax—another anti-epileptic medication—and the Caredios were instructed to 

restart Trileptal. Id. The frequency of D.C.’s seizures decreased with the addition of this 

medication, but they did not completely resolve. Id. It was recommended that D.C. undergo an 

MRI to further evaluate her seizure activity. Id. D.C. was discharged from Valley Children’s 

Hospital on June 16, 2014. 

An MRI was performed on August 4, 2014, but its results did not providea readily-apparent 

etiology for D.C.’s seizures —though nonspecific T2 hyperintensities in the frontal region of the 

centrum semiovale region of the brain were observed. Ex. 7 at 13. Approximately two weeks later, 

on August 22, 2014, D.C. was admitted to Stanford’s Lucile Packard Children’s Hospital. Ex. 5 at 

3. 
5

During this admission, treaters sought to identify the underlying etiology for what was now 

being described as epilepsia partialis continua (“EPC”). 4 Ex. 5 at 3. Treaters identified several 

potential underlying/explanatory diagnoses, including Rasmussen's encephalitis, 5 autoimmune 

etiologies, and/or mitochondrial etiologies. Id. D.C. was also started on a three-day course of 

intravenous methylprednisolone, after which she began receiving prednisone and intravenous 

immunoglobulin (“IVIG”) once daily for four days. Id. Due to an inability to tolerate the 

prednisone, D.C. was transitioned to prednisolone. Id. D.C. began to experience some 

improvements in her right eye with these treatments, but the seizure activity in her right cheek and 

shoulder remained unchanged. Id. 

On August 23, 2014, D.C. underwent a repeat EEG, which now showed “diffuse slowing 

and left centro-temporal spike and wave.” Ex. 5 at 144. These findings were consistent with “focal 

epilepsy with left posterior hemisphere focus, and possible epilepsia partialis continua (EPC).” Id. 

at 6. MRI and lumbar puncture studies were unrevealing. Id. at 5, 152–53, 160. Mitochondrial and 

autoimmune etiologies were suspected, though treaters, including neurologist Katherine 

Mackenzie, M.D., also continued to consider the possibility of Rasmussen’s encephalitis. Id. at 3, 

25. D.C. was discharged on September 3, 2014. 

Petitioners returned to Lucile Packard Children’s Hospital on September 19, 2014. Ex. 5 

at 164. During this visit, D.C. was evaluated in the Neuroimmunology Clinic by Drs. Keith Patrick 

Van Haren (who testified in this matter) and Jennifer Frankovich. Id. at 164–70. During her review 

of D.C.’s medical history, Dr. Frankovich noted that D.C.’s partial seizures began in March 2014 

but had worsened in August. Id. at 168. During the visit, D.C. received IVIG and experienced a 

dramatic decrease in the severity of her symptoms. Id. at 166. Thus, both Drs. Van Haren and 

Frankovich proposed in reaction that D.C.’s seizures were likely the result of an autoimmune 

process, given the effectiveness of the IVIG treatment. Id. at 166, 170. To confirm this assessment, 

Drs. Van Haren and Frankovich recommended a steroid taper and follow-up appointment. 

Petitioners adopted this recommendation and agreed to initiate the steroid taper, which 

resulted in an almost immediate reduction in D.C.’s symptoms. Ex. 5 at 171. D.C. had been 

experiencing seven to nine episodes a day since starting her taper, but was now down to three or 

fewer while receiving the full steroid dose. Id. Dr. Van Haren thereafter cut the steroid taper trial 

short and instructed Petitioners to administer the full dose of IVIG, which further proved 

ameliorative. Id. D.C. later returned to the Neuroimmunology Clinic for a follow-up appointment 

with Dr. Van Haren, during which he discussed D.C.’s lack of response to antiepileptic 

4 EPC is a form of status epilepticus with focal motor seizures, marked by continuous clonic movements of a limited 

part of the body. Dorland’s at 626.

5 Rasmussen’s encephalitis/Rasmussen’s syndrome is a rare form of encephalitis featuring focal lesions in one 

hemisphere of the brain, and is characterized by epilepsy and hemiparesis (one-sided muscle weakness). Dorland’s at 

606, 827.
6

medications and the likelihood that her condition was the result of an autoimmune process. Id. at 

172. In order to better evaluate the potential role of autoimmunity, however, Dr. Van Haren 

ordered a number of laboratory studies, while advising a continuation of IVIG and Solumedrol 

treatments. Id. at 173. 

Treaters thereafter struggled, as before, to identify the source or nature of D.C.’s illness. 

Cerebral spinal fluid (“CSF”) studies of neurotransmitter metabolites derived results within normal

limits. Ex. 5 at 233. In addition, an initial Epilepsy-Autoimmune Evaluation performed on August 

27, 2014, was unrevealing; although subsequent studies performed later that fall were positive for 

a single specific category of antibody, treaters attributed this finding to the IVIG treatments D.C. 

had received just prior to the evaluation. Id. at 232, 234, 298. Genetic testing revealed that D.C. 

was heterozygous for three different genetic variants with pathogenic correlates, including 

myoclonic epilepsy, episodic ataxia, familial hemiplegic migraine, and cerebral arteriopathy with 

subcortical infarcts. Id. at 243. The significance of these findings was questioned, however, 

because the seizures D.C. experienced differed from those caused by the identified variants. Id. at 

243, 297–98. Mitochondrial genome sequencing was also completed, but again produced unclear 

findings. Id. at 298. 

On the morning of December 23, 2014, D.C. woke up in her usual state of health, but 

shortly thereafter began experiencing seizures with increasing frequency. Ex. 5 at 204. Petitioners 

took D.C. to the Memorial Hospital Los Banos emergency department, and following a physical 

examination and review of D.C.’s medical history, she received a 175 mg dose of Solumedrol. Ex. 

6 at 337, 341, 343. D.C. was then transferred by ambulance to Lucile Packard Children’s Hospital

for steroid pulse treatment. Id. at 344; Ex. 5 at 204. During her admission, the onset of D.C.’s 

symptoms was now reported as “[o]ne week after her [flu] immunization” and it was again noted 

that D.C. did not experience relief with antiepileptic medications. Ex. 5 at 204. The following day, 

December 24, 2014, pediatrician, Dr. Ian Chua, M.D., evaluated D.C. for “[EPC] with likely 

autoimmune involvement.” Id. at 208. She was hemodynamically stable during this evaluation, 

and Dr. Chua noted that D.C. had remained seizure free since receiving the Solumedrol treatment 

at Memorial Hospital Los Banos. Id. at 211. 

A neurology consultation was performed the same day by Dr. Susy Shu-Hsin Jeng, M.D. 

Ex. 5 at 213–20. Following a thorough evaluation, including a review of D.C.’s medical history, 

laboratory findings, and physical examination, Dr. Jeng determined that a reduction of D.C.’s 

steroid and IVIG dosage was the most likely explanation for the unexpected exacerbation of her 

condition. Id. at 219–20. Thus, it was determined that D.C. should receive three days of treatment 

with Solumedrol followed by a prednisone taper. Id. at 220.
7

Treatment in 2015 and Beyond

Not long after being discharged from the hospital in late 2014, D.C. began to experience 

seizures with increasing frequency. Ex. 5 at 204, 247. Rather than tapering D.C.’s steroid dose, it 

was doubled but without improvement. Id. at 247. After returning to Lucile Packard Children’s 

Hospital for additional IVIG treatment in early January 2015, a repeat EEG was performed, the 

results of which were again abnormal. Id. at 269. Jin Hahn, M.D., who interpreted the EEG, noted 

that D.C. experienced “frequent epileptiform potentials from the left posterior hemisphere.” Id. 

These findings were deemed consistent with focal/partial epilepsy with left posterior hemisphere 

focus. Id. Petitioners were instructed to continue administering three different antiepileptic 

medications, with a fourth to be considered if D.C.’s seizures persisted. Id. at 263. 

On January 26, 2015, D.C. was admitted to University of California, San Francisco 

(“UCSF”) for a repeat EEG and brain MRI. Ex. 35 at 1. Julian Villar, M.D. reviewed D.C.’s 

medical history, at which time he noted that the onset of D.C.’s EPC occurred after receiving the 

flu vaccine when she was two years old. Id. at 2. No seizures were noted during Dr. Villar’s 

physical exam, but the repeat EEG revealed “worsening epileptiform burden” compared to prior 

EEG studies. Id. at 2, 5. D.C. was discharged home with instructions to follow-up with the Pediatric 

Epilepsy Clinic in two weeks. Id. at 5. 

D.C. returned to the Pediatric Epilepsy Center on February 2, 2015. Ex. 8 at 289. She was 

evaluated by Joseph Sullivan, M.D. (the second treater who testified in this matter), who recorded 

the following note: 

“During this 60 minute visit I spent 40 minutes counseling about the perplexing nature of 

her IVIG responsive epilepsy. I explained that this response does not prove that her 

epilepsy has an autoimmune component but I will leave the additional autoimmune 

evaluation up to Dr. Van Haren. While she has EPC her clinical presentation does not fit 

with Rasmussen syndrome, although I would be very interested to repeat her brain MRI to 

see if there has been any gradual, subtle left hemispheric changes. At this point I would not 

escalate her therapy as she seems to be responding to the IVIG. I will be very interested to 

see if my colleague Dr. Porter has any other diagnostic considerations and the family will 

keep us informed.”

Ex. 8 at 289. 

On February 16, 2015, D.C. again returned to Lucile Packard Children’s Hospital due to 

increasing seizure frequency and prolonged duration presumed to be autoimmune in etiology. Ex. 

5 at 277, 283. She was admitted for a three-day course of IVIG treatment as well as an MRI with 

spectroscopy to evaluate for lesions associated with Rasmussen’s syndrome/encephalitis. Id. The 

MRI, which was conducted on February 18, 2015, showed “a few nonspecific T2 and FLAIR 
8

hyperintense spots within the centrum semiovale bilaterally, unchanged compared to prior study.” 

Id. at 321. The study was otherwise unremarkable, and D.C. was discharged on February 19, 2015. 

Id. at 321, 277–82.

In April 2015, D.C. was evaluated by neurologists Heather Olsen, M.D., and Leslie 

Benson, M.D., at Boston Children’s Hospital. See Ex. 2. Both Drs. Olsen and Benson described 

the onset of D.C.’s illness as abruptly occurring approximately one or two weeks after receiving 

the flu vaccine (although the record is not fully consistent with that history). Id. at 1–2, 28. Notably, 

both physicians distinguished the “fever and tremulousness” D.C. experienced within hours of 

receiving the vaccine from the “onset of focal seizures in February 2014.” Id. at 1–2, 28. Following 

thorough examinations and complete reviews of D.C.’s family and medical history, Drs. Olson 

and Brenson both opined that the etiology of her EPC remained unclear. Id. at 7, 33. While Dr. 

Brenson continued to consider Rasmussen’s encephalitis and autoimmune triggers, Dr. Olson 

opined that D.C.’s clinical picture was largely inconsistent with Rasmussen’s, and thus focused on 

the possibility of metabolic and/or genetic etiologies. Id. at 4, 8, 33. Both agreed that D.C. should 

continue receiving MRIs in addition to undergoing more extensive genetic and autoimmune 

testing, plus an addition course of IVIG. Id. at 8, 34. 

On June 24, 2015, D.C. returned to UCSF where she was admitted and evaluated by Dr. 

Brian Gin, M.D. of the Pediatric Epilepsy Center for concerns relating to “facial seizures, 

hallucinations, sudden fear with dyscognitive features.” Ex. 35 at 30–32, 43. Based upon the 

history provided to him by Petitioners, Dr. Gin documented the onset of D.C.’s EPC as occurring 

in “February 2014 when she developed irregular facial movements and eye twitching that was 

sometimes also associated with dropping objects.” Id. at 43. During this admission, D.C. 

underwent repeat EEG and MRI studies. Id. at 30–32. The results of the EEG again demonstrated 

“frequent left posterior parietal epileptiform discharges.” Id. at 33, 55–56. D.C. was discharged on 

June 25, 2015 with instructions to follow-up on September 30, 2015 with Dr. Sullivan. Id. at 65. 

For the remainder of 2015, D.C. continued to receive repeat EEGs and IVIG therapy at 

UCSF throughout 2015. Ex. 35 at 101, 217, 344, 507. She also continued to demonstrate symptoms 

of EPC, corroborated by abnormal EEG results. Id. at 101, 144, 156, 233, 251, 347. Though the 

etiology for D.C.’s illnessremained elusive, her responsiveness to IVIG treatment was consistently 

cited by treaters as evidence of an immune-mediated process. Id. at 120, 122, 135, 226–29, 372.

Additional evaluation and testing performed in late 2015 was again inconsistent with a 

Rasmussen’s diagnosis or an autoimmune-oriented disease. Ex. 35 at 507, 509, 528.

Testing performed in the first half of 2016 confirmed the presence of focal motor seizures 

and worsening epileptiform burdens. Ex. 3 at 4; Ex. 35 at 596, 600. Additional seizure activity 

occasionally required additional hospitalization, but EEG readings did not always reveal evidence 

of significant increases in activity. Ex. 3 at 4. By the second half of 2016, however, D.C. began to 
9

receive psychological treatment for behavior difficulties associated with her condition and the 

intrusive treatments she was compelled to undergo. See, e.g., Id. at 66. Her anxiety was deemed 

connected to the trauma of her seizure treatments. Id. at 70. On August 11, 2016, Dr. Sullivan 

stated in a letter that D.C. had an unexplained, immune-mediated epilepsy that appeared to present 

after a vaccination. Ex. 10. He wrote that it was in her best medical interest not to receive any 

further vaccinations for the rest of the school year. Id.

Later on that fall, D.C. seemed to improve somewhat, leading treaters to cease IVIG 

treatment. Ex. 35 at 849. She was now given the diagnosis of EPC, “initially IVIG-responsive.” 

Id. By the summer of 2017, additional follow-up EEGs revealed further reduction in seizure 

activity. Id. at 918. Indeed, a record from a November 2017 telehealth visit with Dr. Sullivan states 

that D.C. remained off her EPC medication at that time, but was stable in terms of overall seizure 

activity, leading him to conclude that additional EEG testing was unnecessary at that time, 

although he did wish to follow up with her in six months. Ex. 42 at 1. A record from a subsequent 

visit with Dr. Sullivan in August 2020 was consistent in evaluating her EPC as largely stable. Ex. 

46 at 1. And in a September 2020 letter (prepared and filed after this action’s initiation), Dr. 

Sullivan opined that D.C. had experienced treatment-resistant epilepsy, and that “[d]espite an 

exhaustive work-up the etiology of her epilepsy and EPC remains unknown.” Ex. 47 at 1.

II. Witness Testimony

A. Fact Witnesses

1. Luke Caredio – D.C.’s father was the first fact witness to testify. Tr. at 6-

54. As he explained, D.C. is the older of the two Caredio children, and was a happy and active 

infant prior to receipt of the flu vaccine. Id. at 7–8. The Caredios initial felt it wise to make sure 

D.C. was vaccinated due to concerns at the time in the San Francisco Bay region of influenza 

outbreaks. Id. at 8. Mrs. Caredio therefore brought D.C. to the pediatrician on January 22, 2014, 

around noon. Id. at 9. D.C. had no evident symptoms before vaccination. Id. at 10.

That evening, however, after arriving home from work, Mr. Caredio recalls (around 6 p.m.) 

seeing D.C. look at him “with a kind of dazed look, glazed eyes,” and appearing nonresponsive. 

Tr. at 11. D.C. did not seem warm in a febrile way. Id. In the process of trying to comfort her, Mr. 

Caredio noticed D.C. was shaking and continued to seem nonresponsive, with the shaking lasting 

for 15 minutes. Id. at 11–12. Mr. Caredio felt that something was likely wrong with D.C., and he 

and his wife made the decision to take her to the ER. Id. at 12.

By the time the Caredios reached the hospital, D.C. was no longer shaking, but had a fairly 

high temperature. Tr. at 13. They informed treaters of D.C.’s strange behavior they had witnessed, 

and Mr. Caredio compared her shaking to having the chills or straining for a bowel movement. Id. 

at 12. Although a contemporaneous record from this hospital visit stated that D.C. was “alert and 

talking the whole time,” Mr. Caredio recalled that she was awake but largely unresponsive and 
10

silent. Id. at 15. She had no other symptoms of illness at this time, however, although Mr. Caredio 

recalled his concern that D.C. may have had a vaccine reaction. Id. at 16. Treaters proposed she 

had experienced a febrile seizure, and instructed the Caredios to use over-the-counter pain 

relievers, releasing the family to go home. Id. at 13. 

That night, D.C. continued to run a temperature above 100 degrees, although it was lower 

than what she had displayed earlier at the hospital, and she was restless. Tr.at 13–14.The next day, 

while Mr. Caredio was at work, Mrs. Caredio called him to say that D.C. had experienced another 

shaking episode and that she was taking her back to the hospital. Id. at 14, 17. By this point, Mr. 

Caredio was concerned that D.C. was experiencing a vaccine reaction, especially in light of 

warnings given about how vaccines could cause fever and other transient symptoms. Id. at 16.The 

Caredios were advised by treaters to use over-the-counter pain relievers and monitor D.C. further. 

Id. at 18.

Mr. Caredio’s next recollection of any noticeable symptoms he observed in D.C. was the 

beginning of an eye twitch/flutter in February 2014, in response to fear or anxiety. Tr. at 18. D.C. 

would display the twitch once a day on average, but her pediatrician informed the Caredios that it 

was not of concern. Id. at 18-19. The following month (March), when the Caredios were out to 

dinner, Mr. Caredio recalled that D.C. displayed a hand jerking while holding food in her hand—

a new behavior. Id. at 20-21. The Caredios did not seek treatment or evaluation of this behavior at 

this time, however. Id. at 48-49. In fact, as Mr. Caredio acknowledged, D.C. was not taken to any 

treater between her January 2014 ER visits and the May visit—nearly four months—to evaluate 

the symptoms he testified to observing in the interim time period. Id. at 49-50.

Then, in May 2014, Mrs. Caredio phoned Mr. Caredio to inform him that D.C. had another 

hand twitch incident while eating causing her to drop her food, along with her eyes rolling back, 

and that this was observed also by Mrs. Caredio’s mother, Debra Townsend. A few days later, on 

May 13, 2014, Mrs. Caredio again called Mr. Caredio to tell him she had observed a more 

pronounced version of the same behaviors. Id. at 22. In response, the Caredios took D.C. back to 

the hospital, and were told by treaters D.C.’s behavior might be attributable to a seizure. Id. By 

this time, D.C. was also more regularly displaying face twitches and shoulder hunching. Id. at 24. 

However, Mr. Caredio acknowledged that the medical record from this visit did not reflect or 

memorialize any reported symptoms from the prior months he had allegedly witnessed (although 

he reiterated his recollection of being told D.C.’s initial eye twitching was merely a tic). Id. at 51-

52. 6

A CT scan was performed, but it showed nothing concerning. Id. at 23. D.C. was no 

prescribed anti-seizure medication, although the side effects it caused (face swelling in particular) 

led the Caredios to request that the medicine be suspended. Id. at 26-27. Mr. Caredio also recalled 

6 Mr. Caredio attempted to differentiate the tempo of symptoms increase in May 2014 from February, explaining that 

the eye twitching he and his wife had previously noticed was infrequent/sporadic, whereas in May the frequency had 

increased over the week prior to the Caredios seeking medical intervention for D.C. Tr. at 51, 52-53.
11

that D.C. underwent an EEG, the results of which supported an epilepsy diagnosis. Id. at 27. This 

led to further hospitalization and anti-seizure treatment, but also the recommendation that the 

Caredios seek further treatment with more qualified neurologic specialists. Id. at 27-28.

To that end, the Caredios took D.C. to Stanford Children’s Health. Tr. at 28-29. Treaters 

initially informed Mr. Caredio that D.C.’s epilepsy was not the worst kind they could think of 

EPC, only to state after review of an EEG that in fact that was the proper diagnosis. Id. at 29. The 

process of testing that D.C. underwent at this time was very difficult to endure for the Caredios 

and was very comprehensive. Id. at 30. D.C. was now on multiple medications, none of which 

seemed to be effective, while D.C.’s health and presentation deteriorated. Id. at 31-32. But one of 

D.C.’s treating neurologists, Dr. Cho told Mr. Caredio that immune-modulating therapies (in 

particular, steroids or IVGV) might be effective if in fact D.C.’s condition was an autoimmune 

response to her January 2014 vaccination. Id. at 32; Ex. 5 at 53. And in fact, D.C. responded 

positively to these treatments, leading the Caredios to approve periodic IVIG courses going 

forward. Id. at 34-36.

After D.C. had a seizure incident in December 2014, the Caredios decided they would 

again look for even more qualified expertise, leading them to visit the Neurology Depaartment at 

Boston Children’s Hospital. Tr. at 36-37. Based on the evaluation received there, however, the 

Caredios concluded that the care D.C. was already receiving in California was competent, although 

they subsequently opted to move her care from Stanford to UCSF, where she could receive periodic 

IVIG treatments (although the distance to the Caredios’s home in Los Banos, California was still 

significant). Id. at 38. D.C. also began to require some speech therapy due to stuttering associated 

with her epilepsy. Tr. at 41. 

Today, Mr. Caredio testified, D.C. is largely doing better, and her seizure activity is under 

control (although she occasionally has one or a related flare-up). Tr. at 42-43. She also displays 

some memory issues. Id. at 44. 

2. Jamielee Caredio – Mrs. Caredio’s testimony was consistent with that of 

her husband. See generally Tr. at 54-99. D.C. had no evident symptoms on the day she received 

the flu vaccine in January 2014, and seemed otherwise healthy. Id. at 57. But later that day, she 

recalled, her husband informed her of D.C.’s shaking incident and febrile seizure, leading the 

Caredios to take her to the hospital. Id. at 58-59. At the hospital, she had a fairly high temperature, 

which she had not displayed when the seizure incident had begun at home. Id. at 60. After leaving 

the hospital, D.C.’s temperature moderated, but “never fully dropped.” Id. at 61. The next day, 

Mrs. Caredio personally witnessed the second shaking episode that prompted her to take D.C. back 

to the hospital. Id. at 61-62.

At this second visit, Mrs. Caredio recalled that D.C. was “awake,” and literally alert (in 

that her eyes were open), but she was not verbalizing either. Tr. at 64. After discharge, Mrs. 

Caredio first began to suspect that D.C. symptoms might be vaccine-related, given the temporal 
12

association and the fact (as Mr. Caredio also stated) that pediatricians had warned that vaccination 

could produce a fever. Id. at 65. She also testified that she later (in February) mentioned to D.C.’s 

pediatrician, Dr. Deldin, that Mr. Caredio had noticed the eye twitch, and that Dr. Deldin had 

proposed to watch its development. Id. at 65-66. Mrs. Caredio acknowledged there was no 

reference to such discussions in Dr. Deldin’s written notes from pediatric visits with D.C., but she 

observed that Dr. Deldin’s notes were illegible, and also that in her experience he was not the kind 

of treater who would necessarily write everything down said to him. Id. at 66-67, 90-92.

Mrs. Caredio testified she first personally noticed D.C.’s eye fluttering on May 13, 2014, 

during dinner, when D.C. repeatedly dropped pizza from her hand while it jerked. Tr. at 67-68. 

She also witnessed D.C.’s eyes rolling back on the 19th. Id. at 89. However, she also alleged to 

have noticed what seemed like a nervous “quick little blink” before, in February of that year. Id. 

at 68, 69.7 This blinking/eye twitch did not, however, concern Mrs. Caredio prior to May, until it 

evolved in nature and began occurring more frequently. Id. at 69, 92-93. After the May 13th

incident, she contacted her husband then Dr. Deldin, who instructed the Caredios to take D.C. to 

the hospital, where she was given anti-seizure medication. Id. at 69-70. D.C. also around this time 

underwent an EEG that suggested to treaters she had epilepsy. Id. at 70-71.

After this time, Mrs. Caredio recalled, D.C.’s seizures worsened, eventually leading the 

Caredios to seek specialized expertise at Stanford. Tr. at 71-72. Like her husband, Mrs. Caredio 

recalled the pain of learning that D.C. suffered from a severe form of epilepsy. Id. at 72-73. This 

began an extended period of treatment at Stanford, with little working until IVIG was tried. Id. at 

73-76. After that, the Caredios brought D.C. back to Stanford every few weeks for more IVIG, 

which was helpful until December 2014, when D.C. experienced some more severe seizure flares.

Id. at 76-79. Mrs. Caredio also echoed her husband’s testimony about their effort to obtain a second 

opinion in Boston, and subsequent determination to establish care at UCSF. Id. at 81-82.

Overall, D.C. displays great anxiety in addition to her seizures. Tr. at 82-83. The anxiety 

can flare up in tandem with increased seizure activity. Id. at 83. She can also be more emotionally 

sensitive during symptomatic flares, and did previously require some speech therapy to address 

seizure-induced stuttering. Id. at 84-85. And she displays memory issues as well. Id. at 86. Mrs. 

Caredio also reviewed with Petitioners’ counsel a number of photos of D.C. over the course of her 

treatment, at Stanford and UCSF. Id. at 95-99.

3. Sharon Caredio – Mr. Caredio’s mother Sharon, grandmother to D.C., 

testified about her observations of D.C.’s symptoms. Tr. at 114-33. She recalled D.C. being a 

happy playful child in their interactions (and she saw D.C. fairly regularly because she lives in the 

same town as Petitioners). Id. at 115. She recalled learning from her son about D.C.’s initial postvaccination reaction, but also testified that she had personally seen D.C.’s eye blinking/twitching, 

7 In their affidavit, Petitioners more specifically state that D.C.’s blinking and right eye fluttering began three weeks 

after her initial seizure that resulted in an ER visit at their local hospital on January 22, 2014. See Affidavit, filed Jan. 

26, 2017 (ECF No. 6-2) (“Caredio Aff.”). Petitioners state “[w]e initially thought it might be a nervous twitch.” Id. 
13

in the time period after vaccination (although she could not precisely say when). Id. at 116-18, 

128. She did not, however, observe D.C.’s May 2014 eye-rolling or hand-flutter incidents. Id. at 

119. She did visit D.C. when hospitalized after May, and witnessed there D.C.’s seizure behaviors 

as well as her attendant anxiety. Id. at 119-21. And she was familiar with other sequelae of D.C.’s 

condition, although (in part due to the Pandemic) she had not recently seen D.C. in person. Id. at 

122-27.

4. Deborah Townsend – Mrs. Caredio’s mother (and D.C.’s maternal 

grandmother) also testified about her knowledge and observations of D.C.’s seizure course. Tr. at 

132-52. Like Sharon Caredio, Mrs. Townsends lives near the Caredios and personally saw her 

daughter almost every day, and therefore had opportunities to observe directly D.C.’s behavior 

and symptoms. Id. at 134-35. D.C. before vaccination had been a happy, loving child. Id. at 134-

35. Mrs. Townsend learned from Mrs. Caredio about the immediate post-vaccine ER visit and 

associated shaking/febrile seizure, but had directly seen instances (which she recalled she first 

noticed a few weeks after the January febrile seizure incident, although she could not be precise) 

in which D.C. displayed an eye twitch that was more pronounced when she was anxious. Id. at 

136-38, 149-50. The twitch was not present pre-vaccination. Id. at 139.

Thereafter, Mrs. Townsend recalled, D.C. frequently displayed similar twitching, often in 

response to fatigue or anxiety, although she could not recall if it happened on a daily basis. Tr. at 

139. She learned from her daughter that the twitching had become worse, however – and she was 

present at the initial May incident in the car with D.C. and Mrs. Caredio when D.C. displayed the 

seizure-like hand movement when holding some food. Id. at 140-41. She later learned about D.C.’s 

lengthy treatment course, and even had the opportunity to see her at Stanford or UCSF, where she 

observed D.C.’s fearful reactions to the medical interventions she endured. Id. at 141-44.

B. Petitioners’ Experts/Treater Witnesses

1. Keith Van Haren, M.D. – Dr. Van Haren, a Stanford pediatric neurologist, 

treated D.C. from the fall of 2014 until the spring of 2015, and he testified about his resulting 

treatment observations. Tr. at 100-13. Dr. Van Haren is currently Assistant Professor in the 

Department of Neurology, Stanford University School of Medicine, Division of Child Neurology 

at Lucile Packard Children’s Hospital. See Curriculum Vitae, filed Jan. 22, 2021 (ECF No. 63-2) 

(“Van Huren CV”). His clinical area of expertise is in pediatric neuroimmunologic disorders with 

a special focus on inherited etiologies. Id.; Tr. at 101. 

Dr. Van Haren began seeing D.C. in the fall of 2014, at which time Petitioners were

struggling to identify an effective treatment, since anti-seizure medications did not seem to be 

working. Tr. at 102. However, because (at the time of referral) it was thought that D.C.’s seizures 

“had begun in a setting of fever and post-vaccination”—a supposition not supported by the medical 

record, as reviewed above—it was suspected that she might have suffered from an autoimmune 

encephalitis. Id. at 102-03. By then, she was receiving both steroids and IVIG—and although both 
14

impact immune function, the latter was especially understood to assist with individuals suffering 

from “an overactive immune system.” Id. at 103, 104-05. Dr. Van Haren proposed to taper the 

steroids given their side effects—butsince this was also likely to lead to an increase in seizure 

activity, it would confirm the immune-mediated character of her condition. Id. at 103-04.

D.C.’s response was as Dr. Van Haren expected, leading him to treat her monthly with 

IVIG—which in turn proved effective (other than her December 2014 flare). Tr. at 104. This 

prompted Dr. Van Haren to propose in his treatment records that a “focal autoimmune injury” to 

a small region on the left side of her brain could be the proximate reason for her epilepsy course. 

Id. at 105-06; Ex. 5 at 172. He ultimately agreed with an earlier treater assessment that D.C. 

suffered from drug-resistant “medically intractable EPC due to autoimmune disorder.” Id. at 107-

08.

On cross, Dr. Van Haren acknowledged he had not cared for D.C. from the time of her 

initial vaccination or during her May 2014 presentation of first seizures. Tr. at 109. He also noted 

that the records from his initialvisit with D.C. suggested onset of neurologic symptoms in February 

2014—and that histories provided by the Petitioners, rather than independent records, were the 

primary corroboration for that onset determination. Id. at 111-12. Dr. Van Haren offered no 

opinion as to whether the flu vaccine itself was causal of D.C.’s condition. Id. at 112, 113.

2. Lawrence Steinman, M.D., PhD. – Dr. Steinman, a neurologist and 

immunologist, was the sole non-treating medical expert to testify for Petitioners. Tr. at 155-83,

Report, dated April 12, 2017 (ECF No. 11-2) (“Steinman First Rep.”); Report, dated Jan. 4, 2018 

(ECF No. 28-3) (“Steinman Second Rep.”); Report, dated July 6, 2018 (ECF No. 35-2) (“Steinman 

Third Rep.”). He testified that the flu vaccine likely caused D.C. to experience some form of 

autoimmune epilepsy.

Dr. Steinman is currently a professor at Stanford University, Departments of Neurology, 

Pediatrics and Genetics. Curriculum Vitae, filed July 6, 2018 (ECF No. 35-3) (“Steinman CV”). 

He has published over five hundred peer-reviewed publications on immunology and molecular 

mimicry. Steinman CV at 5-46. He has maintained a large research lab for the past forty-one years, 

particularly in the area of neuroimmunology, and he has published papers on Rasmussen’s and 

other autoimmune epilepsies. Tr. at 156-57. Dr. Steinman is board certified in neurology and has 

received several professional awards and prizes in the specialty. Steinman CV at 1, 2. Dr. Steinman 

alleges that he maintains a clinical practice in inpatient child neurology, with the majority of these 

patients having epilepsy. Tr. at 161. Dr. Steinman recalled that he has diagnosed or treated 

“thousands” of patients with epilepsy, 8 although he has only ever seen four patients with 

Rasmussen’s syndrome/encephalitis. Id. at 161-62. 

8 Dr. Steinman testifies frequently in the Program—and has often informed the special masters he appears before that, 

whatever the injury in question, he has repeatedly had occasion to treat or diagnose it. See, e.g., McGrail v. Sec'y of 

Health & Hum. Servs., No. 17-926V, 2021 WL 1728706, at *10 (Fed. Cl. Spec. Mstr. Apr. 23, 2021) (estimating he 
15

Dr. Steinman began by discussing the different types of epilepsy, explaining that it is a 

broad classification containing several subsets. Tr. at 162. Some types of epilepsy are genetic, 

some metabolic, and some are due to other neurological injury or brain malformation. Id. at 162-

63. Dr. Steinman’s opinion also often touched on Rasmussen’s encephalitis—a progressive, 

chronic encephalitis (inflammation of the brain) occurring mainly in children and impacting one 

side of the brain—using it as a comparable condition, given its known autoimmune pathology and 

the fact that it is characterized by seizures consistent with what D.C. experienced. However, Dr. 

Steinman acknowledged that in fact D.C. was never so diagnosed (and had not even received the 

biopsy necessary to confirm it (Id. at 180)), adding that at most her treaters had speculated that 

aspects of her clinical presentation were “Rasmussen’s-like.” Id. at 218, 235; see also Steinman 

First Rep. at 7 (“[h]er overall picture is not fully consistent with Rassmusen [sp] Encephalitis”), 8.

Dr. Steinman agreed that the medical record supported the conclusion that D.C. had “focal 

epilepsy” manifesting as EPC, which was likely autoimmune in etiology. Tr. at 167, 211. EPC 

usually begins in a focal manner (meaning specific to a particular location in the brain), but not 

necessarily with a “full-blown” seizure. Id. at 172. It is also often a manifestation of Rasmussen’s 

syndrome. S. Varadkar et al., Rasmussen’s Encephalitis: Clinical Features, Pathobiology, and 

Treatment Advances, 13 Lancet Neurology 1, 2 (2014), filed as Ex. 30 Ref. 15 on Apr. 12, 2017 

(ECF No. 12-7) (“Varadkar”). Given Dr. Steinman’s admission that D.C. likely did not have 

Rasmussen’s syndrome, however, it becomes difficult to understand why so much of his expert 

opinion delved into that syndrome’s features, other than the fact that it is believed to be 

autoimmune-driven.

Importantly, Dr. Steinman distinguished D.C.’s purported initial febrile seizure from what 

the Petitioners observed starting to occur a few weeks later—eye twitching—which he deemedthe 

“undisputed beginning” of her EPC. Tr. at 211 (“I’m not necessarily drawing a bridge between the 

febrile seizure initially and what happened a few weeks later with the eye twitching”). Thus, Dr. 

Steinman did not connect D.C.’s febrile seizure at all to her subsequent disorder—and even if the 

vaccine had caused her to suffer a fever which in turn caused the isolated seizure possibly observed 

on January 22, 2014, Dr. Steinman did not contend that this seizure was the onset of her alleged 

vaccine-caused injury. Id. at 266-67.

has treated hundreds of patients with transverse myelitis and similar neurological conditions such as multiple sclerosis 

and neuromyelitis optica); Salazar v. Sec'y of Health & Hum. Servs., No. 15-817V, 2021 WL 319393, at *9 (Fed. Cl. 

Spec. Mstr. Jan. 5, 2021) (stating he has cared for hundreds of adults and children with various forms of brachial 

plexus injuries, peripheral neuropathy, and autoimmune neurologic conditions); Taylor v. Sec'y of Health & Hum. 

Servs., No. 13-700V, 2018 WL 2050857, at *7 (Fed. Cl. Mar. 9, 2018) (estimating he has treated over 2,500 patients 

with multiple sclerosis, Guillain-Barré syndrome (“GBS”), or Acute Demyelinating Encephalomyelitis (“ADEM”)); 

Rolshoven v. Sec'y of Health & Hum. Servs., No. 14-439V, 2018 WL 1124737, at *6 (Fed. Cl. Spec. Mstr. Jan. 11, 

2018) (stating he has treated over 1,000 patients with headaches during his 35 year career); Blackburn v. Sec’y of 

Health & Hum. Servs., No. 10-410V, 2015 WL 425935, at *7 (Fed. Cl. Jan. 9, 2015) (stating he has treated 

approximately 400 patients with GBS). But even accepting Dr. Steinman’s overall competence and expertise in 

neurologic matters, the contention that he has vast deep background exposure to virtually any neurologic injury is 

exceedingly difficult to swallow.
16

Next, Dr. Steinman explained his theory associating the flu vaccine to a conditionlike EPC. 

Overall, he contended that D.C.’s EPC was the product of an aberrant adaptive immune response 

to the flu vaccine, driven by T cells. Steinman First Rep. at 9. He forthrightly acknowledged that 

he was unable to offer any literature connecting the flu vaccine to EPC (though he added that 

recognized medical authorities like the Institute of Medicine (the “IOM”) had not yet disproven 

the possibility). Tr. at 240. Instead, Dr. Steinman’s theory depended on a number of separate 

components he attempted to link together. 

First, Dr. Steinman noted that certain types of epilepsy are driven by autoimmune disease 

processes. First Steinman Rep. at 9; National Institute of Neurological Disorders and Stroke, 

Rasmussen’s Encephalitis Information Page, available at 

https://www.ninds.nih.gov/disorders/alldisorders/rasmussensencephalitisinformationpage (last 

visited Apr. 12, 2017), filed as Ex. 22, Ref. 7 on Apr. 12, 2017 (ECF No. 11-9). As a result, it was 

plausible a vaccine (which impacts the immune system) could play a role in initiating an

autoimmune form of epilepsy.

Second, Dr. Steinman proposed that the flu vaccine could do so via the scientificallyrecognized biological mechanism of molecular mimicry. Steinman First Rep. at 10. Antigenic 

components of the vaccine could, he proposed, stimulate the immune system to cross-react with 

self tissue structures due to similarity between the components and the amino acid sequences 

making up the structures (meaning the immune system response to the vaccine would secondarily 

lead to an autoimmune attack). Id. In fact, many neuronal antigens are linked to certain 

autoimmunity-driven diseases featuring seizures, like Rasmussen’s syndrome, having been 

revealed to be targets for antibodies critical to these autoimmune disease processes. Id.; A. Nibber 

et al., Antibodies to AMPA Receptors in Rasmussen’s Encephalitis, 20 European J. of Paediatric 

Neurology Society, 222-27 (2016), filed as Ex. 26, Ref. 11 on Apr. 12, 2017 (ECF No. 12-3)

(“Nibber”). 

In Nibber, 52 patients with Rasmussen’s syndrome were tested by cell-based assays for 

antibodies associated with Rasmussen’s, and ten had evidence of antibodies to specific neuronal 

antigens. Nibber at 222. Other literature has suggested that the direct injection of known molecular 

mimics into animals can induce an experimental form of autoimmune disease. First Steinman Rep. 

at 17; A. Gautam et al., A Viral Peptide with Limited Homology to a Self-Peptide Can Induce 

Clinical Signs of Experimental Autoimmune Encephalomyelitis, 161 J. of Immunology 60-64 

(1998), filed as Ex. 26, Ref. 12 on Apr. 12, 2017 (ECF No. 12-4). While Dr. Steinman 

acknowledged that it was not established by such literature that autoantibodies to neuronal antigens

believed associated with human seizure-featuring conditions would also induce clinical 

neuroinflammation simply by their introduction, he nevertheless deemed the articles useful in 

understanding the nature of the autoimmune process that could explain causation in this case. First 

Steinman Rep. at 13. 
17

To demonstrate how the flu vaccine specifically could cause the creation of cross-reactive 

autoantibodies central to such a proposed autoimmune process resulting in EPC, Dr. Steinman 

endeavored to show “homology,” or antigenic similarity, between the vaccine’s components and 

self neurologic structures. He did so via BLAST9 searches. Steinman First Rep. at 13. Specifically, 

Dr. Steinman reviewed online databases, looking for homologies between antigenic components 

found in the 2013-14 version of the flu vaccine (which he deemed a reasonable comparable to the 

version received by D.C.) and NMDA-R10 and GABA11 neuronal receptors (among others) which 

are suspected to be targets for attack in certain autoimmune-driven epilepsies. Tr. at 243. In his 

estimation, the number of matched common amino acids in sequence (matches of more than five 

out of twelve) was enough to support the conclusion that the 2014 influenza vaccine could also

stimulate a cross-reaction. Id. at 175; 221-23.

At trial, however, Dr. Steinman admitted that demonstrating a theoretical basis for

homology is only the first step to establishing a possible causal association. Tr. at 223-24. Indeed, 

he went so far as to acknowledge that his contentions about the plausibility of a vaccine-induced 

cross reaction attributable to molecular mimicry was the most he could offer in support of his 

contention that the flu vaccine could cause an epileptic disorder like EPC. Id. at 262-63 (“I made 

my opinion based on I can’t come up with a—anything better, and I can come up with a theory 

based on molecular mimicry to explain it”). He also acknowledged that the “widespread” existence 

of sequential homology between different self tissue structures and foreign antigens undercut the 

causal potential of vaccinesto instigate autoimmune illness(and the immune system was equipped 

to effectively deal with the vast majority of resulting cross-reactive potential), but added that the 

presence of “other genetic and environmental factors” were what made the homology dangerous, 

and that molecular mimicry overall remained “key mechanism” in explaining the loss of immune 

tolerance in some circumstances. Steinman Second Rep. at 4-5.

Another stumbling block to Dr. Steinman’s theory was the fact that the neuronal receptors 

that Dr. Steinman deemed homologous with some of the flu vaccine’s antigenic components are 

not located solely in the brain. Tr. at 176. But the “antibody-mediated CNS degeneration” 

described by Dr. Steinman would involve a directed attack against the purportedly-homologous

receptors. Ex. 15 at 21; Tr. at 236. If so, why did D.C. experience focal rather than generalized 

seizures, arising fromcross-reactions occurring elsewhere in the body or even brain? Dr. Steinman 

defended his view by asserting that medical science could not provide an answer to that. Id. He 

9 Basic Local Alignment Search Tool (“BLAST”) is a medical/scientific internet resource that assists researchers in 

finding regions of similarity between biological sequences of amino acids. The program compares nucleotide or 

protein sequences to sequence databases and calculates the statistical significance. BLAST, U.S. National Library of 

Medicine, https://blast.ncbi.nlm.nih.gov/Blast.cgi (last visited Nov. 19, 2020).

10 NMDA stands for N-Methyl-D-Asperate. Dorland’s at 1260.

11 GABA stands for Gamma-aminobutyric acid. Dorland’s at 745.
18

added that a likely genetic susceptibility to D.C.’s condition may also have played a role. Id. at 

225-26.

In addition, Dr. Steinman’s theory was further complicated by the immunologic character 

of autoimmune cross-reactions—which generally involve autoantibodies driving the disease 

process. The timing and nature of the vaccine reaction D.C. was alleged to have experienced most 

likely involved the adaptive arm of the immune response, since her initial symptoms (eyefluttering) manifested two to three weeks post-vaccination (and thus could not have been the 

product of the immediate, innate response). Steinman First Rep. at 9. As Dr. Steinman explained,

the adaptive immune response is driven by a combination of T cells (which often, although not 

exclusively, play a direct role in attacking invading pathogens) and B cells (which cause the 

manufacture of antibodies). Ex. 15 at 9; Tr. at 237. And his theory proposed that autoantibodies 

could have been stimulated by antigenic components of the flu vaccine. And yet—antibody tests 

D.C. received in the fall of 2014 were negative for any detectable antibodies to many proteins 

associated with autoimmune seizures. Tr. at 238 ((citing Ex. 5 at 234-36); Steinman First Rep. at 

8; M. Toledano & S. Pittock, Autoimmune Epilepsy, 35 Semin Neurology 245, 245-47 (2015) filed 

as Ex. A Tab 2 on Oct. 17, 2017 (ECF No.20-3). Thus, the record did not establish that the 

antibodies likely to be involved in an autoimmune pathologic process were present.

Dr. Steinman responded by maintaining that even in the absence of detectable antibodies 

to many proteins associated with autoimmune seizures, T cell response is capable of inflicting 

considerable damage, deeming it the likely basis for D.C.’s epilepsy. Tr. at 237-38; Steinman First 

Rep. at 21 (“[s]uch antibodies are far less frequent than T cell responses in the pathogenesis of 

these autoimmune mediated epileptic conditions”). Indeed, he cited literature in support of the 

conclusion that despite the fact that certain autoantibodies were very “specific” to the neuronal 

targets of attack, their role in directly propagating autoimmune epilepsies (or larger syndromes 

like Rasmussen’s manifesting as EPC) was not clear. Steinman First Rep. at 21; Varadkar at 5. Dr. 

Steinman thus concluded that “T cells are considered more likely the culprits in the pathogenesis 

of . . .. other immune mediated epilepsies.” Steinman First Rep. at 20; Id. at 2.

But in so arguing, Dr. Steinman simultaneously attempted to play down the extent to which 

he relied solely on T cells as the likely immune system mediator of disease in this case. In 

particular, he pushed back against the assertions of Respondent’s expert (Dr. Christine McCusker) 

that his causation theory centered around a specific kind of T cell (CD8+ cytotoxic cells) as 

attacking the purportedly-homologous neuronal receptors—even though those receptors were not 

“implicated” in a T cell-driven processes. Steinman Third Rep. at 3. In reaction, Dr. Steinman 

clarified that invariably autoimmune processes still involve T cells. Id. (“B cell responses require 

T cell help”). In particular, a different class of T cells - CD4+ “helper” T cells - assist B cells in 

the process of manufacturing antibodies. Steinman Third Rep. at 3. Thus, T cells do likely play a 

role in autoimmune epilepsy. Id. In addition, all such T cells have “cytotoxic capabilities,” and 

that in fact Rasmussen’sinvolves both (although as already noted Dr. Steinman had conceded D.C. 

did not likely have Rasmussen’s). Tr. at 226-29.
19

Moving on to the medical history, Dr. Steinman endeavored to show how D.C.’s disease 

course was consistent with his causation theory. Since this was the first time D.C. had received the 

flu vaccine, it was highly unlikely she was experiencing a recall response in the hours immediately 

following vaccination. Moreover, although Dr. Steinman allowed for the possibility that she had 

experienced a febrile seizure in reaction, he did not connect that initial reaction to D.C.’s ultimate 

EPC diagnosis Tr. at 211-12, 213. In fact, because his theory for how the vaccine caused EPC 

relied on molecular mimicry (a process requiring an adaptive immune response), the absence of a 

possible recall response (in which a second exposure would prompt a more rapid reaction) meant 

that D.C.’s injury could not have begun with the febrile seizure. Id. at 213. Thereafter, however, 

the disease process began, and Dr. Steinman felt it unmistakable that D.C.’s twitches observed by 

her family were its start, evolving later to the outright seizures. Id. at 174. The subsequent 

chronicity of D.C.’s condition could be from “nests of T and B cells that take up residence in the 

brain and then periodically get triggered,” based on his experience with other neuroinflammatory 

diseases. Id. at 270.

Dr. Steinman also deemed the ameliorative effect of IVIG therapy, which is known to be 

efficacious in the treatment of autoimmune conditions, as supporting his causation opinion. Tr. at 

215.12 And although D.C.’s testing for evidence of autoimmune etiologies at Mayo Clinic 

produced negative results, Dr. Steinman opined that the testing was not all-inclusive, and that some 

of the assays tested are “fragile,” meaning that a negative response did not necessarily rule out an 

autoimmune epilepsy. Id. at 177-78. Treaters otherwise were unable to identify any other 

explanatory cause, like a genetic etiology, making D.C.’s responsiveness to the first-line immune 

therapies that are given for autoimmune epilepsy (namely corticosteroids and IVIG) “the best 

evidence we had.” Id. at 178. On cross-examination, however, Dr. Steinman agreed that record 

evidence showed that the utility of IVIG treatment is not always proof of autoimmunity, since it 

can indirectly help treatment of epilepsy given its inflammatory mechanisms. Id. at 240.

The timing of D.C.’s onset, Dr. Steinman maintained, was consistent with his theory. Tr. 

at 168-69, 229-30. He opined that the eye twitching episodes observed in February 2014 

constituted the first concrete manifestation of EPC. Id. at 171. Until that point, her condition was 

subclinical. Thereafter, consistent with how EPC progresses over time, D.C.’s symptoms 

progressed from eye fluttering into facial twitches, which in turn eventually progressed to hand 

and shoulder shaking in May 2014. Id. at 174. By this time D.C. had developed a “persistent 

12 Dr. Steinman strongly disagreed with the suggestion by Respondent’s other expert, Dr. Jenny Linnoila, that 

conclusions regarding the efficacy of IVIG should depend on formal confirmationof the treatment’s utility via clinical 

or structured immune therapy trials.Tr. at 216-17.He argued instead that it would be unethical to put such limits on 

treatment simply for the purpose of evaluating diagnostic relevance. Tr. 215-16. The topic was extensively addressed 

in some of Dr. Steinman’s supplemental reports as well as those prepared by Dr. Linnoila. See, e.g., Steinman Second 

Rep. at 1-2; Steinman Third Rep. at 1-3; Linnoila First Rep. at 6-7; Linnoila Second Rep.at 3-4; Linnoila Third Rep. 

at 1-5. This dispute between the experts did not, however, appreciably assisted my determination of this case—and 

there were ample independent bases for finding Dr. Steinman’s causation theory wanting. 
20

memory response” to the vaccine, making an on-going cross reaction driven by the vaccine likely. 

Id. at 214.

Dr. Steinman offered some items of independent literature to support his timeframe 

arguments (which effectively posited that the January 22nd vaccination did not cause a 

manifestation of EPC- related symptoms before some unspecified time in February 2014—ten to 

21 days post-vaccination). In particular, he referenced articles supporting the medical acceptability 

of a ten-day post-immunization onset of encephalomyelitis. First Steinman Rep. at 22; L. Bennetto 

& N. Scolding, Inflammatory/Post-Infectious Encephalomyelitis, 75 J. Neurol. Neurosurg. 

Psychiatry i22-i28 (2004), filed as Ex. 32, Ref. 17 on Apr. 12, 2017 (ECF No. 12-9) (“Bennetto & 

Scolding”); Tr. at 218-19. Bennetto & Scolding, however, specifically discusses the postvaccination timeframe for acute demyelinating encephalomyelitis (“ADEM”)—a typicallymonophasic neurologic injury distinguishable from EPC. Benneto & Scolding at i22. Dr. Steinman 

nevertheless deemed such evidence the “best fit I could find,” given the lack of literature specific 

to post-vaccination EPC onset. Tr. at 257, 262.

Dr. Steinman otherwise felt a ten-day onset was supported by basic immunology principles. 

Within five to seven days of receipt of a flu vaccine, the adaptive arm of the immune system would 

begin making IgG, a potent antibody. Tr. at 258. Since EPC would (at least mostly) be antibodydriven, it would take this long for initial symptoms to manifest—consistent with what occurred in 

D.C.’s case. Dr. Steinman later testified, however, that he could also support a one-day onset in 

cases where an individual had previously received the same vaccine, or (on the longer end) up to 

a four-month onset based on literature covering different vaccines. Id. at 258, 260. When asked 

what the maximum onset time period he would support was, Dr. Steinman said anything from 42 

days to a year was possible. Tr. 246-48 (citing other kinds of immune-mediated diseases such as 

GBS or NMO). 

Finally, Dr. Steinman called into question some proposed alternative causes for D.C.’s 

condition offered by Respondent’s experts. For example, Dr. Jenny Linnoila (whose opinion is 

discussed in greater detail below) noted medical record evidence of left-side lobe cortical 

thickening as possibly explaining D.C.’s illness. Although Dr. Steinman did not dispute the record 

support for this observation, he did not find that it was pursued by D.C.’s treaters. Tr. at 231. He 

also stated that there was no genetic test results that could illuminate the cause of D.C.’s EPC. Id. 

at 232.13

13 I also note that throughout his testimony, Dr. Steinman repeatedly tried tovouch for his own credibility—although 

doing so backfired. Thus, he purported not to be an advocate for Petitioners herein (Tr. at 163, 166), but instead a 

neutral professional whose north star was science, emphasizingthat he did not always accept cases for claimants when 

he did not feel he could fairly offer an opinion to support a particular claim (Id. at 164). Yet Dr. Steinman admitted 

his ultimate utility as an expert was measured not by whether he had offered a reliable independent opinion, but rather 

whether he had crafted an opinion that might helpPetitioner succeed. See, e.g., Id. at 164 (“when I am seen [at hearing], 

I can make a theory and support a case”), 166-67 (his goal is to determine “whether I could make any type of theory 

that would connect the vaccine that petitioner actually received . . . and the injury we’re talking about today”).
21

3. Joseph Sullivan, M.D. – Dr. Sullivan, the neurologist who has treated D.C. 

at UCSF, offered testimony describing that process. Tr. at 184-208. Dr. Sullivan is currently a 

professor of neurology and pediatrics and Director of the Pediatric Epilepsy Center at the 

University of California San Francisco. Curriculum Vitae, filed as Ex. 65 on Jan. 22, 2021 (ECF 

No. 63-3) (“Sullivan CV”). He is board certified in clinical neurophysiology, neurology, epilepsy, 

and pediatrics. Sullivan CV at 1-2. In his professional career, Dr. Sullivan has diagnosed more 

than 1,000 pediatric patients with seizure disorders, including approximately ten patients with 

autoimmune epilepsy and three patients with Rasmussen’s. Tr. at 186-87. 

Dr. Sullivan first met D.C. after she had already had an extensive workup done at Boston’s 

Children’s Hospital in April 2015—which produced a diagnostic hypothesis of immune-mediated 

epilepsy. Tr. at 187. Dr. Sullivan testified that it was very clear to him that D.C. had EPC (where 

one part of the body has continuous motor activity). Id. at 188. Rasmussen’s 

syndrome/encephalitis, or a possible underlying brain injury, were also possible diagnoses, along 

with some rare mitochondrial or metabolic diseases or focal cortical dysplasia. Id. 

Dr. Sullivan began his evaluation of D.C. with a brain MRI and an immune workup, which 

was the starting point to look for radiologic manifestations of Rasmussen’s or focal cortical 

dysplasias. Tr. 188-89. At this point in D.C.’s treatment, Dr. Sullivan favored a Rasmussen’s or 

Rasmussen’s-like diagnosis, given the focal nature of her seizure activity and one-sided weakness,

although the propriety of a Rasmussen’s diagnosis required consideration of the patient’s evolution 

over time—and in particular to look for evidence of progressive atrophy on MRI. Id. at 189-190. 

But D.C. recovered from certain of these suggestive presenting elements, which meant her 

presentation was never more (in retrospect) than “Rasmussen’s-like.” Tr. at 190-91. In fact, Dr. 

Sullivan acknowledged, after six or seven years of treatment D.C.’s course could not be said to 

reflect the typical trajectory of a Rasmussen’s patient. Id. at 195. A future MRI would help confirm 

an absence of Rasmussen’s progression. Id. at 196-97. 

Despite some suggestion from the record that D.C.’s illness may be best understood as 

EPC, Dr. Sullivan opined that no firm diagnosis yet existed to explain her condition. At best, it 

was likely some kind of “immune-mediated epilepsy” regardless of whether it is in fact

Rasmussen’s. Tr. at 201, 208. On cross-examination, Dr. Sullivan admitted D.C.’s case did not fit 

 In past cases, Dr. Steinman has been criticized forstepping outside his role of medical expert to opine on the legal 

standards to be applied in Program cases. See e.g., D.G. v. Sec'y of Health & Hum. Servs., No. 11-577V, 2019 WL 

2511769, at *189 (Fed. Cl. Spec. Mstr. May 24, 2019); Rolshoven v. Sec'y of Health & Hum. Servs., No. 14-439V, 

2018 WL 1124737, at *10, 21 (Fed. Cl. Spec. Mstr. Jan. 11, 2018). Although he refrained from doing so in this case, 

his various asides herein amounted to a different kind of “unforced error” that greatly detracted from his credibility. 

For he seemed to admit that an expert’s job is to “shill” for the claimant, without regard for the independence and 

adherence to scientific principles he maintained guided him in deciding whether to offer an opinion in the first place. 

Dr. Steinman would be well advised in future cases to stick to the facts, and to explain only why his causation theory 

is reliable based on his own expertise—not to make comments that suggest he is aware there is less to his opinion 

than meets the eye.
22

a Rasmussen’s diagnosis, and that at bottom her EPC is “of unclear etiology” despite an 

“exhaustive immune workup.” Id. at 203, 204; Ex. 46 at 1. This is consistent with the letter Dr. 

Sullivan prepared for Petitioners. See generally Ex. 47. 

D.C.’s treatment was now focused on “understanding the correlation between her EPC and 

her EEG findings” in conjunction with how she was doing on a day-to-day, week-to-week basis to 

help guide potential interventions and slow down the progress of the disease. Tr. at 191. D.C. had 

already received steroids and IVIG, which would aid in slowing progression or perhaps even stop 

the disease, obviating the need for more severe interventions. Id. at 191-92. Dr. Sullivan was 

unable to say that D.C.’s condition would never get worse—which was possible with either 

Rasmussen’s or EPC. Id. at 192-93. Dr. Sullivan also acknowledged that a positive IVIG response 

did not necessarily equate with an underlying immune cause, because “anti-inflammatory 

immunologic treatments” often are employed for individuals who do not respond to more usual 

therapies. Id. at 204-05. And while he could not say whether the flu vaccine was casual despite a 

temporal association, he recommended that D.C. not receive future vaccinations. Id. at 200, 206.

C. Respondent’s Experts

1. Christine McCusker, M.D., PhD. – Dr. McCusker, a pediatric immunologist 

and microbiologist, testified on behalf of Respondent, and also submitted three written reports. See 

generally Tr. at 273-335; Report, dated Oct. 17, 2017, filed as Ex. C (ECF No. 21-1) (“McCusker 

First Rep.”); Report, dated April 10, 2018, filed as Ex. F (ECF No. 32-3) (“McCusker Second

Rep.”); Report, dated Sept. 21, 2018, filed as Ex. H (ECF No. 37-5) (“McCusker Third Rep.”). Dr. 

McCusker contested Petitioners’ contention that the flu vaccine could cause EPC or did so to D.C.

Dr. McCusker obtained a Bachelor’s degree in microbiology and immunology from the 

University of Toronto. McCusker First Rep. at 1; Dr. McCusker Curriculum Vitae, filed as Ex. D 

(ECF No. 26-7) (“McCusker CV) at 1. She holds a master of science degree in molecular biology 

from McMaster University, where she also completed three years of a PhD program in 

immunology before attending medical school and obtaining her MD. Id. Dr. McCusker completed 

her residency training in pediatrics at the Montreal Children’s Hospital and a clinical fellowship 

in allergy and immunology at McGill University in Montreal, Quebec. McCusker CV at 1-2. 

Currently, she is an Associate Professor of Pediatrics at McGill University and Division Director 

of Pediatric Allergy, Immunology and Dermatology at the Montreal Children’s Hospital. Tr. at 

274; McCusker First Rep. at 1. Dr. McCusker is also a clinical scientist with a fundamental 

research lab affiliated with the Meakins-Christie Labs of McGill University where her research 

focus is on the regulation of the immune responses. McCusker First Rep. at 1. She holds peer 

reviewed external grants from both Canadian and U.S. granting agencies, and she regularly 

publishes in peer-reviewed journals. Id. 

Dr. McCusker began by broadly contesting whether there was any reliable evidence linking 

the flu vaccine to autoimmune epilepsy. Tr. at 278, 289. She noted that some of the general 
23

evidence offered by Dr. Steinman to link vaccines to autoimmune diseases involved different

conditions, like immune thrombocytopenic purpura. McCusker Second Rep. at 4. But clinical 

epilepsy studies did not reveal an increased incidence in infants of EPC or other seizure disorders 

post-vaccination. Id. at 319; K. Kotloff et al., Clinical and Immune Responses to Inactivated 

Influenza A(H1N1)pdm09 Vaccine in Children, 33 Pediatric Infectious Disease J. 865, 869-70

(2014), filed as Ex. C, Tab 2 on Oct. 17, 2017 (ECF No. 21-3) (“Kotloff”).Indeed, Dr. McCusker 

deemed the version of flu vaccine administered to infants and toddlers “actually a very poor 

immunogen.” Tr. at 292; McCusker First Rep. at 4. Studies like Kotloff have established that 

barely a fourth of children “seroconvert,” or develop antibodies to the wild flu virus, after the first 

dose of vaccine, and therefore it was generally unlikely that autoimmune cross-reactions would 

occur after its receipt. Tr. at 292-93; McCusker First Rep. at 4; Kotloff at 870.

In particular, the flu vaccine “poorly activate[s] CD8+ve T cells”—despite Dr. Steinman’s 

heavy reliance on that particular immune cell as driving the pathologic process in question. 

McCusker First Rep. at 4; A. Altenburg et al., Virus-specific T Cells as Correlate of (Cross-) 

Protective Immunity Against Influenza, 33 Vaccine 500 (2015), filed as Ex. C, Tab 1 on Oct. 17, 

2017 (ECF No. 21-2); N. La Gruta & S. Turner, T Cell Mediated Immunity to Influenza: 

Mechanisms of Viral Control, 35 Trends in Immunology 396, 401 (2014) filed as Ex. C, Tab 3 on 

Oct. 17, 2017 (ECF No. 21-4). By contrast, a variety of wild viral/bacterial infections were known 

to produce robust responses in the relevant demographic age group, including the kind of T cells 

invoked in Dr. Steinman’s theory (although Dr. McCusker admitted there was no objective proof 

in this case that D.C. possessed a prior infection that could stand as a potential alternative cause 

for her EPC). Tr. at 333-34; McCusker First Rep. at 4.

Next, Dr. McCusker reviewed a number of aspects of Dr. Steinman’s opinion that she felt 

were inadequate or unreliably supported. First, she took general issue with his embrace of a 

homologous cross-reaction as a pathogenic explanation for how the flu vaccine could initiate an 

autoimmune-driven epilepsy disorder. Dr. McCusker accepted Dr. Steinman’s logic in looking for 

homology between brain receptors likely associated with focal seizures (although there were 

potentially “hundreds” in the brain that could be relevant) and the flu vaccine’s components. Tr. 

at 318. She noted, however, that sequential homology could easily be demonstrated throughout the 

human body. Id. at 279 (“you can actually find homologies to so many other brain proteins that 

are not found in the brain”). 

Indeed, Dr. McCusker noted that she had been able (via her own “in silica” 14 research

comparable to what Dr. Steinman performed for this case) to identify homology between the 

human brain receptor targets identified by Dr. Steinman and otherinfectious wild viruses common 

to children, like rhinovirus or cytomegalovirus (“CMV”), but not otherwise associated with EPC 

14 Dr. Steinman in a prior case coined this phrase to encapsulate the computer database-search “research” he often 

performs to identify homology between a given vaccine and alleged injury. See e.g., Blackburn v. Sec'y of Health&

Hum. Servs., No. 10-410V, 2015 WL 425935, at *10 (Fed. Cl. Spec. Mstr. Jan. 9, 2015).
24

or seizure disorders. McCusker First Rep. at 5-9; Tr. at 287-88. She identified six amino acid 

homology (out of a series of nine) for CMV, and six of twelve for the rhinovirus. McCusker First 

Rep. at 6. She observed similar sequential homology when comparing wild flu virus sequences 

with some cell surface receptors very common to immune system cells. Id. at 7-9. Because of the 

“ubiquitous distribution” of these receptor proteins, an autoimmune attack on them “would likely 

result in massive tissue destruction”—and yet there was no known autoimmune association known 

between them and the wild flu virus. Id. at 9.

Dr. McCusker also deemed it illogical to assume that a cross-reaction instigated by 

vaccination would only occur in the brain, since vaccines are administered peripherally (and hence 

would be more likely to cause cross-reactions with homologous tissues closer to the situs of 

administration). Tr. 286-87, 310, 318. Thus, mere demonstration of homology does not

automatically mean autoimmune cross-reactivity is more likely—since if that were the case “none 

of us would survive our first viral infection,” when in fact autoimmune-driven diseases are 

uncommon. Id. at 279-80. The immune system is, Dr. McCusker explained, actually prepared to 

resist cross-reaction, even in presence of autoantibodies. Id. at 281, 283-84. Possession of diseaseassociated antibodies also is no guaranty of a pathologic response, since there are many instances 

where individuals test positive for antibodies associated with disease or other damaging processes 

(like allergies) but do not become ill. Id. at 290; McCusker First Rep. at 10. Rather, for a disease 

process to arise, a “next step” is required. Tr. at 280.

Second, Dr. McCusker attacked other aspects of Dr. Steinman’s theory relating to the 

proposed homology-driven autoimmune process leading to EPC. Tr. at 284. She agreed that certain 

brain neuronal receptors (NMDA-R and GABA) identified by Dr. Steinman were known to be 

associated with specific autoantibodies. McCusker Second Rep. at 2. But “neither of these 

receptors have been implicated in T cell-mediated diseases”—which Dr. Steinman plainly 

identified as the pathologic engine in this case. Id. at 3. In fact, D.C. had never been diagnosed 

with any of the diseases specifically associated with these neuronal receptors, like NMDA-R 

encephalitis. Id. at 2. And a 2013 study only found (in a 564-patient cohort) that less than two 

percent of patients with new-onset epilepsy even possessed the NMDA-R antibodies, and therefore 

their presence did not predict course or outcome—and could in fact be “an epiphenomena of 

refractory seizures” rather than causal of them. Id.; T. Brenner et al., Prevalence of Neurologic 

Autoantibodies in Cohorts of Patients with New and Established Epilepsy, 54 Epilepsia 1028 

(2013), filed as Ex. F Tab 2 on Apr. 10, 2018 (ECF. No. 32-5).

Dr. McCusker relatedly pointed out that the record did not establish that D.C. possessed 

the autoantibodies specific to these two receptors focused upon in Dr. Steinman’s homology 

BLAST searches. Tr. at 299-300. Although Dr. Steinman had proposed that the level of required 

autoantibodies could be impacted by some of the treatments D.C. was receiving (like IVIG or 

steroids), thus reducing what testing could reveal, Dr. McCusker insisted they would not be 

rendered wholly undetectable, so a test result that D.C. was negative for them, as here, was 
25

trustworthy. Id. at 300-01. And she also took issue with the animal model15 relied upon by Dr. 

Steinman to show how autoimmune cross-reactive diseases progress, arguing that (a) it relies on 

adjuvant-driven overstimulation, and hence does not provide a particularly apt comparable for the 

functioning of a child’s immune response, and (b) it has more relevance to antibody-driven disease 

processes (which, as noted below, are inconsistent with Dr. Steinman’s view of how an EPC or a 

similar autoimmune epilepsy would occur, i.e. via T cells). Id. at 291-92, 298.

Dr. McCusker spent a considerable amount of time addressing Dr. Steinman’s theory 

regarding the role T cells would play in EPC or some other kind of autoimmune epilepsy, and 

whether the flu vaccine in particular could have any impact on such a process. Tr. at 281. She 

expressed considerable doubt about the latter, noting that any T cells activated by vaccination 

would not persist for a long period of time, and would have to “find their target” in the brain (a far 

less accessible location than peripheral myelin, which Dr. Steinman’s EAE models focused on) to 

cause injury. Id. at 309-10. She also stressed that mimicry-driven T cell activation would require 

evidence about how the vaccine’s antigen mimics would “present” to the self tissues, such that 

they could prompt cross-reactivity. McCusker First Rep. at 5; McCusker Second Rep. at 3. A T 

cell could not cross-react with a brain receptor, even given some degree of sequential homology, 

unless it “recognized” it. Tr. at 296. But Dr. McCusker denied that Dr. Steinman had provided any 

evidence that the antigenically-similar segments he had identified via online research could do 

this.16 Id. (“you have to say, would a T cell see this? Because if a T cell won’t see it, it’s irrelevant 

that there is homology”). Since Dr. Steinman’s causation theory “stopped” after it demonstrated 

potential homology, it did not go far enough in showing that the flu vaccine could promote 

production of the pathogenic T cells that would drive EPC. McCusker First Rep. at 10.

The body’s immunologic “checks and balances” made it even less likely vaccination could 

produce pathologic T cells, since the processes17 by which T cells become “highly educated” 

(meaning in this case able to recognize and cross-react with brain receptors homologous to flu 

antigens) usually results in deletion of the vast majority of potentially pathologic versions. Tr. at 

297, 298, 281-82, 321; McCusker First Rep. at 10; M. Anderson, The Cellular Mechanism of Aire 

Control of T Cell Tolerances, 23 Immunity 227, 237 (2005), filed as Ex. C Tab 10 on Oct. 19, 

2017 (ECF No. 26-1); C. Benoist & D. Mathis, Autoimmunity Provoked by Infection: How Good 

is the Case for T Cell Epitope Mimicry?, 2 Nature Immunology, 797, 800 (2001), filed as Ex. C 

15 Dr. Steinman relied on a model termed “experimental autoimmune encephalomyelitis (“EAE”).” Dorland’s at 580; 

Steinman First Rep. at 11-13.

16 In fact, Dr. McCusker noted, one article filed by Petitioners and relied upon by Dr. Steinman actually suggested that 

the kinds of autoreactive T cells that could purportedly contribute to a specific central nervous system demyelinating 

injury, multiple sclerosis, were also present in individuals without the disease, undercutting the theory of their 

centrality to pathogenesis. McCusker Second Rep. at 4; K. Ota et al.,T-cell Recognition of an Immunodominant Myelin 

Basic Protein Epitope in Multiple Sclerosis, 346 Nature, 183 (1990) filed as Ex. 38 Supp. Ref.1 on Jan.4, 2018 (ECF 

No. 28-4).

17 As Dr. McCusker explained, naïve T cells migrate from the bone marrow to the thymus, where they “undergo 

education,” and thus autoimmune T cells are mostly deleted. Tr. at 281. 
26

Tab 4 on Oct. 17, 2017 (ECF No. 21-5). And other immune cells would likely downregulate the 

overproduction of potentially harmful T cells as well. Tr. at 283. Dr. McCusker admitted, however, 

that (consistent with the fact that the causes of autoimmune diseases generally are not wellunderstood) in autoimmune disease processes some T cells likely did escape elimination in the 

body, and a genetic predisposition to autoimmunity might well play a role in allowing them to 

survive. Id. at 322-23.

Dr. McCusker noted a few other issues with Dr. Steinman’s theory as it pertained to T cells 

and their role in propagating some form of autoimmune epilepsy. She agreed that T cells could be 

implicated in an immune response that was (as with the flu vaccine) primarily oriented toward 

inducing production of antibodies via B cells, although she distinguished the kinds of T cells 

involved: CD4+ “helper” T cells, which communicate with B cells and thus assist with antibody 

production. Tr. at 298-99. But these T cells are not equivalent to the cytotoxic CD8+ T cells 

allegedly involved in the autoimmune attack on brain receptors that Dr. Steinman’s theory posited 

were central to the pathogenesis of autoimmune epilepsy18—and the latter kind of T cell is not 

understood to be activated by the flu vaccine in any event. Id. at 309; McCusker Third Rep. at 2. 

The two kinds of T cells are not even activated in the same way. McCusker Third Rep. at 2. Thus, 

another necessary link connecting the flu vaccine to the relevant disease process was missing. 

Dr. McCusker also provided her view of incidents from D.C.’s medical history and what 

she believed they revealed about the flu vaccine’s purported role in her EPC/autoimmune epilepsy. 

She expressed doubt, for example, that D.C. had in fact experienced a febrile seizure, noting that 

Petitioners had not deemed D.C. “hot” when she first appeared to seize at home, her alert mental 

status was not consistent with seizure, and initial treaters had not clearly defined D.C.’s reaction 

to constitute a febrile seizure either. Tr. at 325-26. Regardless, Dr. McCusker disputed that febrile 

seizures were triggers for epilepsy or other seizure disorders, maintaining that more recent medical 

research was starting to discredit the prior view of a relationship. Id. at 327; McCusker First Rep. 

at 11; N. Verbeek et al., Etiologies for Seizures Around the Time of Vaccination, 134 Pediatrics 

658 (2014) filed as Ex. C Tab 15 on Oct 19, 2017 (ECF No.26-6). She also noted that the medical 

record ultimately did not later corroborate initial treater concerns that D.C. might have 

Rasmussen’s syndrome. McCusker First Rep. at 10.

The efficacy of the IVIG treatments D.C. received, moreover, were not in Dr. McCusker’s 

estimation corroboration of the autoimmune character of her epilepsy. McCusker First Rep. at 10. 

Dr. McCusker deemed IVIG treatments a “powerful anti-inflammatory” that certainly could be 

helpful to people experiencing seizures, but maybe more as “a response to chronic insult to the 

18 Dr. McCusker did not accept at face value Dr. Steinman’s contention about the centrality ofthese CD8+ T cells to 

autoimmune diseases involving seizures, like Rasmussen’s, noting that some of the literature cited for this proposition 

had found only a general increase in proliferation of a lymphocyte specific to a particular antibody-associated neuronal 

receptor—but that it was not confirmed these were T cells, let alone the CD8+ T cells identified as pathogenic by Dr. 

Steinman. McCusker Third Rep. at 2; Y. Takahashi et al., Autoantibodies and Cell-mediated Autoimmunity to NMDAtype GluRε2 in Patients with Rasmussen’s Encephalitis and Chronic Progressive Epilepsia Partialis Continua, 46 

Epilepsia 152, 157 (2005), filed as Ex. 45 Ref. 3 on July 6, 2018 (ECF No. 35-4).
27

central nervous system.” Tr at 304; J. Geng et al., Intravenous Immunoglobulins for Epilepsy, 7 

Cochrane Database of Systematic Revs. 1, 11-12 (2017) filed as Ex. C Tab 12 on Oct. 19, 2017

(ECF No. 26-3). As a result, although Dr. McCusker conceded that treaters may have reasonably 

in part deemed IVIG’s efficacy as supporting an autoimmune etiology, she did not accept that the 

treatment’s utility was strong evidence of this. Id. at 306-07.

Regarding the likely onset for D.C.’s EPC, Dr. McCusker observed a discrepancy between 

when the Petitioners claimed to have first noticed her eye twitching/blinking (February) and the 

onset supported by written medical records (which indicated the eye twitching was first observed 

in mid-May). Tr. at 277-78. Dr. McCusker concluded from this that the evidence best supported a 

later onset. Id. at 311. And although Dr. Steinman seemed to deem even a May onset as medically 

acceptable for causation purposes, Dr. McCusker disagreed, arguing that the slower adaptive 

immune response implicated by Dr. Steinman’s theory would take far less time to occur (and thus 

certainly would not happen over a period of several months, based on her own preferred onset). 

Id. at 312-13. 

Dr. McCusker admitted that a 10-14 day onset would be consistent at least with the time in 

which the flu vaccine would generate IgG antibodies via an adaptive immune process. Tr. at 320.

But she challenged some of the literature Petitioners relied upon to support this timeframe. Benetto

& Scolding, for example, was an older (16-17 years old) paper that not only involved a different 

disease (ADEM) but specifically stated that the incidence of post-vaccination ADEM was more 

common with vaccines manufactured from neuronal tissue, mentioning only the MMR vaccine in 

this regard. Id. at 314-15; Bennetto & Scolding at i24-i25. The flu vaccine was thus 

distinguishable.

Finally, Dr. McCusker questioned the overall timeframe in which the allegedly vaccineinitiated disease process had purportedly occurred. She expressed doubt that a process involving 

“asymptomatic progressive degeneration” (since other than the eye twitching, D.C. was not 

displaying progressive worsening in her clinical symptoms before May) could later manifest, more 

than three months post-vaccination, abruptly as chronic focal seizures, absent evidence of a brain 

tumor or some other obvious injury. Tr. at 313. D.C.’s disease process would not likely have 

proceeded in a stuttering, slowly-progressing fashion—especially since it was proposed in this 

case to be immune-mediated. Id. at 331 (“your immune system doesn’t chip [away]” over weeks 

or months). At bottom, Dr. McCusker reasoned, Dr. Steinman’s theory placed too much reliance 

on the flu vaccine’s pre-onset administration, so that “what Dr. Steinman is describing is 

phenomenology, not causality.” Id. at 334.

2. Dr. Jenny Linnoila, M.D., PhD. – Dr. Linnoila, a neurologist with a 

specialty in studying and treating autoimmune diseases, was Respondent’s second expert, and she 

offered a number of written reports as well. See generally Tr. at 336-415; Report, dated October 

13, 2017, filed as Ex. A (ECF No. 20-1) (“Linnoila First Rep.”); Report, dated April 10, 2018, 
28

filed as Ex. E (ECF No. 32-1) (“Linnoila Second Rep.”); Report, dated September 13, 2018, filed 

as Ex. G (ECF No. 37-1) (“Linnoila Third Rep.”).

Dr. Linniola received her bachelor’s degree in computer science from the University of 

Chicago and studied biochemistry and pharmacology at the University of Cambridge. Dr. Linnoila 

Curriculum Vitae, filed as Ex. CV of Jenny Linnoila on Oct. 17, 2017 (ECF No. 20-9) (“Linnoila 

CV”) at 1. She obtained a Ph.D. in molecular pharmacology along with a medical degree from the 

University of Pittsburgh. Id. Dr. Linnoila completed an internship in internal medicine at 

Alleghany General Hospital before completing a residency and research fellowship in neurology 

at Massachusetts General Hospital and a fellowship in autoimmune neurology at the Mayo Clinic. 

Id. She is currently a specialist in autoimmune neurology at Massachusetts General Hospital. Tr. 

337. She spends approximately 75 percent of her time on laboratory research and 25 percent of her 

time in clinical practice seeing patients with autoimmune and paraneoplastic disorders of the 

central nervous system. Tr. 338. Dr. Linnoila has published many peer-reviewed articles, including 

on the topic of autoimmune encephalitis, and she is boarded in neurology but not pediatrics. Tr. at 

343-44, 385; Linnoila First Rep. at 2. She also has experience in treating individuals like D.C., 

although much of it is derived from a prior clinical fellowship. Id. at 385-86; Linnoila First Rep. 

at 2. Thus, Dr. Linnoila reports to have seen many patients with autoimmune encephalopathies 

(which would include autoimmune epilepsy), and did on rare occasions see children diagnosed 

with EPC. Tr. at 339, 341. She acknowledged, however, that most of this overall experience was 

derived from her residency, and that she more commonly consulted on cases involving these kinds 

of illnesses. Id. at 341-42.

Dr. Linnoila began her testimony by defining some of the medical concepts and terms 

relevant to the case. She defined “encephalopathy” to mean brain inflammation—and in the case 

of autoimmune epilepsy, the inflammation would provoke seizures. Tr. at 340, 341. Because 

autoimmune epilepsy is thought to be a kind of autoimmune encephalitis, some experts believe 

treatment of the underlying inflammation could help reduce the resultant seizures. Id. at 340-41; 

Linnoila Second Rep. at 2. The seizures characteristic of autoimmune epilepsy often appear acutely 

and without warning, and can be severe and resistant to treatment. Tr. at 356-58; Linnoila First 

Rep. at 6. They can also be focal (meaning specific to a part of the brain) or multifocal, and vary 

in type. Linnoila First Rep. at 6. Although autoimmune epilepsy is often responsive to 

immunotherapy, its underlying etiology cannot often be identified even though its autoimmune 

pathogenic character is clear. Tr. at 358, 372-74.

Dr. Linnoila then turned to some of the specific diagnostic categories at issue. EPC is a 

focal process in the brain, and the seizures it produces can be “a nearly constant motor movement 

that can persist for minutes to hours to days, even months in some cases.” Tr. at 349-50; see also 

351; Linnoila First Rep. at 5. The underlying cause of EPC cannot always be determined, 

especially given its rarity, but it has been attributed to tumors, cortical malformation in the brain, 

genetic/metabolic disorders, autoimmune encephalitis, and Rasmussen’s syndrome. Tr. at 351-52, 

374-75. Dr. Linnoila defined Rasmussen’s to be a progressive neuoinflammatory condition 
29

impacting part of the brain (hence focal in nature), producing seizures on one side of the body plus 

brain atrophy. Id. at 352, 354-55; Linnoila First Rep. at 6. Rasmussen’s disease process is poorly 

understood, but the condition itself is aggressive, difficult to control with treatment, and most 

common in children (although rare overall). Tr. at 355.

D.C., Dr. Linnoila opined, most likely suffered from EPC (an opinion largely consistent 

with D.C.’s treaters’ views). Tr. at 348; Linnoila First Rep. at 5. D.C. likely did not have 

Rasmussen’s, despite the fact that many treaters (including Dr. Sullivan) had included it in their 

diagnostic differentials), and in so concluding Dr. Linnoila pointed to D.C.’s overall medical 

history, which did not reveal brain tissue loss/atrophy or other associated progressive neurologic 

decline usually seen in Rasmussen’s. Tr. at 355-56; Linnoila First Rep. at 6, 8. She also agreed 

with Dr. Steinman that D.C.’s immediate vaccine reaction, however classified, was not related to 

D.C.’s later EPC course—although unlike Dr. Steinman, Dr. Linnoila questioned if D.C. had even 

experienced a febrile seizure, given that D.C.’s observed shaking despite no clear loss or lack of 

consciousness was not consistent with a febrile seizure.Tr. at 351, 368-71.

Dr. Linnoila did not completely embrace the conclusion that D.C.’s EPC was most likely

autoimmune in nature. Rather, she opined that no explanatory cause for D.C.’s EPC could be 

identified, with autoimmune epilepsy only one of several plausible/possible explanations. Tr. at 

367-68, 371, 375, 391-92; Linnoila First Rep. at 7; Linnoila Second Rep. at 3. 19Dr. Linnoila found 

particularly compelling the fact that testing had not revealed that D.C. possessed any of the specific 

autoantibodies thought to be associated with autoimmune epilepsy. Tr. at 366-67, 397. She 

admitted that such autoantibodies could not always be found even in cases with “features of 

autoimmune epilepsy,” but maintained that more often than not they would be present if in fact 

the epilepsy arose from an autoimmune process. Linnoila First Rep. at 6; Tr. at 411-13. But, she 

admitted, this did partially explain why it was difficult to be definitive in confirming an 

autoimmune epilepsy diagnosis. Tr. at 413-14.

The evidence of a successful response to IVIG was also not, in Dr. Linnoila’s view, proof 

of the autoimmune character of D.C.’s epilepsy. She admitted that autoimmune neurologic 

illnesses and disorders are often highly responsive to immunotherapies. Linnoila First Rep. at 6. 

She also did not dispute that pre-IVIG, D.C.’s seizures were not responsive to treatment, and that 

fact plus the prior, more severe nature of her course reasonably suggested a possible autoimmune 

etiology given IVIG’s effectiveness.20 Tr. at 365, 395. But seizures are “highly irritating to the 

19 Dr. Linnoila noted, for example, evidence in the medical record suggesting that an MRI had revealed a potential 

left parietal lobe malformation—consistent with the fact that D.C.’s EEG abnormalities occurred in her left brain. Tr. 

at 352-53; Ex. 5 at 295; Linnoila First Rep. at 5. Such a brain malformation was a potential alternative explanation for 

D.C.’s illness.

20 In fact, Dr. Linnoila observed that the record showed that IVIG had notbeen persistently effective. Thus, D.C. had 

experienced seizure relapses in December 2014 (and even later in February 2015), even in the midst of receipt of 

IVIG. Tr. at 415. I note, however, that the record does support the conclusion that the seizures returned in periods in 

which D.C. was not actively receiving an IVIG course. Ex. 5 at 182, 208, 219-20.
30

brain,” exciting the immune system while encouraging additional inflammation (on top of what 

already may have occurred), and hence IVIG might simply be effective in treating the 

inflammation that is secondary to the initial cause of a seizure. Id. at 366. In addition, Dr. Linnoila 

noted that proof of IVIG’s effectiveness is not a diagnostic criteria for autoimmune epilepsy. Id. 

at 396; Linnoila First Rep. at 6-7; F. Graus et al., A Clinical Approach to Diagnosis of Autoimmune 

Encephalitis, 15 Lancet J. 391 (2016) filed as Ex. E Tab 1 (ECF No. 32-2). And IVIG is also not 

specifically associated with the treatment of Rasmussen’s, a rare condition that does not yet even 

have an agreed-upon treatment. Id. at 406-09.

In discussing the above, Dr. Linnoila directly questioned whether the clinical manner in 

which IVIG had been administered to D.C. allowed any reliable conclusions about its efficacy in 

the first place. Tr. at 358, 398-404. She felt only a “structural immunotherapy trial,” in which 

treatment was subject to scientific controls, could shed light on whether the ameliorative nature of 

the treatment was evidence of its underlying autoimmune character. Id. at 358-62, 414. But this 

had not been done in D.C.’s case. Id. at 362-65.21

Moving to the causation questions central to Petitioners’ claim, Dr. Linnoila contested that 

the flu vaccine could cause EPC or an autoimmune epilepsy. Tr. at 375. In so proposing, however, 

she relied greatly on the fact that she was unaware of support for this contention in the medical or 

scientific community. Id. at 372; First Linnoila Rep. at 8-9; See Institute of Medicine, Adverse 

Effects of Vaccines: Evidence and Causality 333 (National Academy of Sciences) (2012), filed as 

Ex. 33, Ref. 18 on April 12, 2017 (ECF No. 12-10). She did observe (in the context of opining that 

D.C. did not likely suffer from Rasmussen’s syndrome) that MRI imaging for D.C.’s brain, 

conducted between August 2014 and February 2015, showed stability, and this “argued against a 

T-cell mediated process” as alleged by Dr. Steinman, since brain atrophy is usually a product of 

such T-cell attack. Linnoila First Rep. at 8.

Dr. Linnoila also contended that D.C.’s symptoms associated with her later diagnoses 

likely did not begin before April or May of 2014, asserting that the Caredios’s recollection of D.C. 

dropping food from her hand around this time sounded like how EPC might initially manifest. Tr. 

at 350-51. But this timeframe from vaccination to first onset was in her view too long to acceptably 

link the flu vaccine to D.C.’s injury. Id. at 375-76. Dr. Linnoila did not accept that D.C.’s onset 

could have begun earlier, manifesting as the eye twitching the Petitioners and other witnesses 

testified to observing closer in time to vaccination. Those observed incidents, she proposed, could 

21 As noted above, Dr. Steinman took specific issue with this point, and he and Dr. Linnoila ended up devoting much 

space in their written reports to address it. See, e.g., Linnoila Second Rep. at 3-4; Linnoila Third Rep. at 1-5. 

Ultimately, however, my resolution of this claim does not turn on whether IVIG’s effectiveness “proved” the 

autoimmune character of D.C.’s epilepsy, or whether it lacked the scientific rigor and controls required to reach that 

conclusion. Preponderant evidence overall slightly bettersupports the conclusion that the ameliorative impact of IVIG 

on D.C. reasonably suggested an autoimmune pathology—although this does not mean the flu vaccine was causal 

simply because D.C.’s epilepsy likely was autoimmune in nature.
31

simply have been evidence of anxiety, like tics, and she found it significant that Petitioners never 

reported them to D.C.’s pediatricians (despite seeking treatment for other issues). Tr. at 347-48, 

379. 22 Such behaviors were also distinguishable from D.C.’s later, more obvious signs of EPC, 

which Dr. Linnoila deemed a “different phenomenon.” Id. at 349, 350. D.C.’s course progression, 

which showed a persistence of eye twitching or blinking even after her more troubling seizures 

and associated involuntary motor movements had ceased, further convinced Dr. Linnoila that the 

initial eye twitching was not EPC-related. Id. at 376-77, 378.

III. Procedural History

After the case’s initiation in January 2017, Petitioners filed medical records supporting the 

claim as well as Dr. Steinman’s first report, with the Statement of Completion filed in August 

2017. ECF No. 17. Respondent’s Rule 4(c) Report, plus the initial reports of Drs. McCusker and 

Linnoila, were all filed in October of that same year. Expert discovery was completed by 

September 2018, and then the case was delayed for several months while it awaited scheduling for 

a hearing. After the matter was transferred to me in July of 2000, I held a status conference with 

the parties and subsequently set the matter for a hearing, to be held January 28-29, 2021. ECF No. 

46. The trial occurred as scheduled, and the matter is now ripe for resolution.

IV. Applicable Legal Standards

A. Petitioner’s Overall Burden in Vaccine Program Cases

To receive compensation in the Vaccine Program, a petitioner must prove either: (1) that 

he suffered a “Table Injury”—i.e., an injury falling within the Vaccine Injury Table—

corresponding to one of the vaccinations in question within a statutorily prescribed period of time 

or, in the alternative, (2) that his illnesses were actually caused by a vaccine (a “Non-Table 

Injury”). See Sections 13(a)(1)(A), 11(c)(1), and 14(a), as amended by 42 C.F.R. § 100.3; § 

11(c)(1)(C)(ii)(I); see also Moberly v. Sec’y of Health & Hum. Servs., 592 F.3d 1315, 1321 (Fed. 

Cir. 2010); Capizzano v. Sec’y of Health & Hum. Servs., 440 F.3d 1317, 1320 (Fed. Cir. 2006).23

In this case, Petitioners do not assert a Table claim.

22 One issue raised in connection with Winter 2014 pediatric visits—particularly to see Dr. Deldin—was the poor 

legibility of his notes or their cursory nature, and whether therefore it was possible that the Petitioners had raised 

concerns about the eye twitching sooner than other records suggested. See, e.g., Tr. at 379-83. Petitioners’ counsel 

also asked Dr. Linnoila many questions about the precise nature of the eye twitch, in an effort to gauge its severity or 

relationship to D.C.’s later seizures. Id. at 386-89. I do not find that either line of inquiry was particularly significant 

in swaying me one way or another in deciding the claim, however. The record sufficiently supports Petitioners’ onset 

contention, and that onset manifested with the eye twitching, without having to evaluate whether handwriting 

illegibility for the relevant pediatric records explains the failure to mention D.C.’s initial EPC-related manifestations 

in those same records.

23 Decisions of special masters (some of which I reference in this ruling) constitute persuasive but not binding 

authority. Hanlon v. Sec’y of Health & Hum. Servs., 40 Fed. Cl. 625, 630 (1998). By contrast, Federal Circuit rulings 

concerning legal issues are binding on special masters. Guillory v. Sec’y of Health & Hum. Servs., 59 Fed. Cl. 121, 
32

For both Table and Non-Table claims, Vaccine Program petitioners bear a “preponderance 

of the evidence” burden of proof. Section 13(1)(a). That is, a petitioner must offer evidence that 

leads the “trier of fact to believe that the existence of a fact is more probable than its nonexistence 

before [he] may find in favor of the party who has the burden to persuade the judge of the fact’s 

existence.” Moberly, 592 F.3d at 1322 n.2; see also Snowbank Enter. v. United States, 6 Cl. Ct. 

476, 486 (1984) (mere conjecture or speculation is insufficient under a preponderance standard). 

Proof of medical certainty is not required. Bunting v. Sec’y of Health & Hum. Servs., 931 F.2d 

867, 873 (Fed. Cir. 1991). In particular, a petitioner must demonstrate that the vaccine was “not 

only [the] but-for cause of the injury but also a substantial factor in bringing about the injury.” 

Moberly, 592 F.3d at 1321 (quoting Shyface v. Sec’y of Health & Hum. Servs., 165 F.3d 1344, 

1352–53 (Fed. Cir. 1999)); Pafford v. Sec’y of Health & Hum. Servs., 451 F.3d 1352, 1355 (Fed. 

Cir. 2006). A petitioner may not receive a Vaccine Program award based solely on his assertions; 

rather, the petition must be supported by either medical records or by the opinion of a competent 

physician. Section 13(a)(1).

In attempting to establish entitlement to a Vaccine Program award of compensation for a 

Non-Table claim, a petitioner must satisfy all three of the elements established by the Federal 

Circuit in Althen v. Sec’y of Health & Hum. Servs., 418 F.3d 1274, 1278 (Fed. Cir. 2005): “(1) a 

medical theory causally connecting the vaccination and the injury; (2) a logical sequence of cause 

and effect showing that the vaccination was the reason for the injury; and (3) a showing of 

proximate temporal relationship between vaccination and injury.” 

Each of the Althen prongs requires a different showing. Under Althen prong one, petitioners 

must provide a “reputable medical theory,” demonstrating that the vaccine received can cause the 

type of injury alleged. Pafford, 451 F.3d at 1355–56 (citations omitted). To satisfy this prong, a 

petitioner’s theory must be based on a “sound and reliable medical or scientific explanation.” 

Knudsen v. Sec’y of Health & Hum. Servs., 35 F.3d 543, 548 (Fed. Cir. 1994). Such a theory must 

only be “legally probable, not medically or scientifically certain.” Id. at 549. Special masters, 

despite their expertise, are not empowered by statute to conclusively resolve what are essentially 

thorny scientific and medical questions, and thus the evidence offered to establish Althen prong 

one is viewed “not through the lens of the laboratorian, but instead from the vantage point of the 

Vaccine Act's preponderant evidence standard.” Andreu, 569 F.3d at 1380.

However, the Federal Circuit has repeatedly stated that the “can cause” prong requires a 

preponderant evidentiary showing. See Boatmon v. Sec'y of Health & Hum. Servs., 941 F.3d 1351, 

1360 (Fed. Cir. 2019) (“[w]e have consistently rejected theories that the vaccine only “likely 

caused” the injury and reiterated that a “plausible” or “possible” causal theory does not satisfy the 

124 (2003), aff’d104 F. Appx. 712 (Fed. Cir. 2004); see alsoSpooner v. Sec’y of Health & Hum. Servs., No. 13-159V, 

2014 WL 504728, at *7 n.12 (Fed. Cl. Spec. Mstr. Jan. 16, 2014).
33

standard”); Broekelschen v. Sec'y of Health & Hum. Servs., 618 F.3d 1339, 1350 (Fed. Cir. 2010); 

see also Moberly, 592 F.3d at 1322 (discussing generally preponderance and the nature of showing 

a claimant must meet in Program cases). This is consistent with the petitioner's ultimate burden to 

establish his overall claim by preponderant evidence. W.C. v. Sec'y of Health & Hum. Servs., 704 

F.3d 1352, 1356 (Fed. Cir. 2013) (citations omitted). If the causation-in-fact evidentiary standard 

requires a preponderant showing, it makes no sense to conclude that standard is relaxed for any of 

the individual prongs making up the showing.

Petitioners may offer a variety of individual items of evidence pertaining to the first Althen

prong, without resort to medical literature, epidemiological studies, demonstration of a specific 

mechanism, or even a generally accepted medical theory. Andreu v. Sec'y of Health & Hum. Servs., 

569 F.3d 1367, 1378–79 (Fed. Cir. 2009) (citing Capizzano, 440 F.3d at 1325–26). The individual 

items of proof offered for the “can cause” prong must each reflect or arise from “reputable” or 

“sound and reliable” medical science. Boatmon, 941 F.3d at 1359-60.

The second Althen prong requires proof of a logical sequence of cause and effect, usually 

supported by facts derived from a petitioner’s medical records. Althen, 418 F.3d at 1278; Andreu, 

569 F.3d at 1375–77; Capizzano, 440 F.3d at 1326; Grant v. Sec’y of Health & Hum. Servs., 956 

F.2d 1144, 1148 (Fed. Cir. 1992). In establishing that a vaccine “did cause” injury, the opinions 

and views of the injured party’s treating physicians are entitled to some weight. Andreu, 569 F.3d 

at 1367; Capizzano, 440 F.3d at 1326 (“medical records and medical opinion testimony are favored 

in vaccine cases, as treating physicians are likely to be in the best position to determine whether a 

‘logical sequence of cause and effect show[s] that the vaccination was the reason for the injury’”) 

(quoting Althen, 418 F.3d at 1280). Medical records are generally viewed as particularly 

trustworthy evidence, since they are created contemporaneously with the treatment of the patient. 

Cucuras v. Sec’y of Health & Hum. Servs., 993 F.2d 1525, 1528 (Fed. Cir. 1993).

Medical records and statements of a treating physician, however, do not per se bind the 

special master to adopt the conclusions of such an individual, even if they must be considered and 

carefully evaluated. Section 13(b)(1) (providing that “[a]ny such diagnosis, conclusion, judgment, 

test result, report, or summary shall not be binding on the special master or court”); Snyder v. Sec’y 

of Health & Hum. Servs., 88 Fed. Cl. 706, 746 n.67 (2009) (“there is nothing . . . that mandates 

that the testimony of a treating physician is sacrosanct—that it must be accepted in its entirety and 

cannot be rebutted”). As with expert testimony offered to establish a theory of causation, the 

opinions or diagnoses of treating physicians are only as trustworthy as the reasonableness of their 

suppositions or bases. The views of treating physicians should be weighed against other, contrary 

evidence also present in the record—including conflicting opinions among such individuals. 

Hibbard v. Sec’y of Health & Hum. Servs., 100 Fed. Cl. 742, 749 (2011) (not arbitrary or capricious 

for special master to weigh competing treating physicians’ conclusions against each other), aff’d, 

698 F.3d 1355 (Fed. Cir. 2012); Veryzer v. Sec’y of Dept. of Health & Hum. Servs., No. 06-522V, 
34

2011 WL 1935813, at *17 (Fed. Cl. Spec. Mstr. Apr. 29, 2011), mot. for review denied, 100 Fed. 

Cl. 344, 356 (2011), aff’d without opinion, 475 F. Appx. 765 (Fed. Cir. 2012).

The third Althen prong requires establishing a “proximate temporal relationship” between 

the vaccination and the injury alleged. Althen, 418 F.3d at 1281. That term has been equated to the 

phrase “medically-acceptable temporal relationship.” Id. A petitioner must offer “preponderant 

proof that the onset of symptoms occurred within a timeframe which, given the medical 

understanding of the disorder’s etiology, it is medically acceptable to infer causation.” de Bazan 

v. Sec’y of Health & Hum. Servs., 539 F.3d 1347, 1352 (Fed. Cir. 2008). The explanation for what 

is a medically acceptable timeframe must align with the theory of how the relevant vaccine can 

cause an injury (Althen prong one’s requirement). Id. at 1352; Shapiro v. Sec’y of Health & Hum. 

Servs., 101 Fed. Cl. 532, 542 (2011), recons. denied after remand, 105 Fed. Cl. 353 (2012), aff’d 

mem., 503 F. Appx. 952 (Fed. Cir. 2013); Koehn v. Sec’y of Health & Hum. Servs., No. 11-355V, 

2013 WL 3214877 (Fed. Cl. Spec. Mstr. May 30, 2013), mot. for rev. denied (Fed. Cl. Dec. 3,

2013), aff’d, 773 F.3d 1239 (Fed. Cir. 2014).

B. Legal Standards Governing Factual Determinations 

The process for making determinations in Vaccine Program cases regarding factual issues 

begins with consideration of the medical records. Section 11(c)(2). The special master is required 

to consider “all [] relevant medical and scientific evidence contained in the record,” including “any 

diagnosis, conclusion, medical judgment, or autopsy or coroner’s report which is contained in the 

record regarding the nature, causation, and aggravation of the petitioner’s illness, disability, injury, 

condition, or death,” as well as the “results of any diagnostic or evaluative test which are contained 

in the record and the summaries and conclusions.” Section 13(b)(1)(A). The special master is then 

required to weigh the evidence presented, including contemporaneous medical records and 

testimony. See Burns v. Sec’y of Health & Hum. Servs., 3 F.3d 415, 417 (Fed. Cir. 1993) (it is 

within the special master’s discretion to determine whether to afford greater weight to 

contemporaneous medical records than to other evidence, such as oral testimony surrounding the 

events in question that was given at a later date, provided that such determination is evidenced by 

a rational determination).

Medical records that are created contemporaneously with the events they describe are 

presumed to be accurate and “complete” (i.e., presenting all relevant information on a patient’s 

health problems). Cucuras, 993 F.2d at 1528; Doe/70 v. Sec’y of Health & Hum. Servs., 95 Fed. 

Cl. 598, 608 (2010) (“[g]iven the inconsistencies between petitioner’s testimony and his 

contemporaneous medical records, the special master’s decision to rely on petitioner’s medical 

records was rational and consistent with applicable law”), aff’d sub nom. Rickett v. Sec’y of Health 

& Hum. Servs., 468 F. Appx. 952 (Fed. Cir. 2011) (non-precedential opinion). This presumption 

is based on the linked propositions that (i) sick people visit medical professionals; (ii) sick people 
35

honestly report their health problems to those professionals; and (iii) medical professionals record 

what they are told or observe when examining their patients in as accurate a manner as possible, 

so that they are aware of enough relevant facts to make appropriate treatment decisions. Sanchez 

v. Sec’y of Health & Hum. Servs., No. 11-685V, 2013 WL 1880825, at *2 (Fed. Cl. Spec. Mstr. 

Apr. 10, 2013); Cucuras v. Sec’y of Health & Hum. Servs., 26 Cl. Ct. 537, 543 (1992), aff’d, 993 

F.2d at 1525 (Fed. Cir. 1993) (“[i]t strains reason to conclude that petitioners would fail to 

accurately report the onset of their daughter’s symptoms”).

Accordingly, if the medical records are clear, consistent, and complete, then they should 

be afforded substantial weight. Lowrie, 2005 WL 6117475, at *20. Indeed, contemporaneous 

medical records are generally found to be deserving of greater evidentiary weight than oral 

testimony—especially where such testimony conflicts with the record evidence. Cucuras, 993 F.2d 

at 1528; see also Murphy, 23 Cl. Ct. at 733 (citing United States v. United States Gypsum Co., 333 

U.S. 364, 396 (1947) (“[i]t has generally been held that oral testimony which is in conflict with 

contemporaneous documents is entitled to little evidentiary weight.”)).

There are, however, situations in which compelling oral testimony may be more persuasive 

than written records, such as where records are deemed to be incomplete or inaccurate. Campbell 

v. Sec’y of Health & Hum. Servs., 69 Fed. Cl. 775, 779 (2006) (“like any norm based upon common 

sense and experience, this rule should not be treated as an absolute and must yield where the factual 

predicates for its application are weak or lacking”); Lowrie, 2005 WL 6117475, at *19 (“’[w]ritten 

records which are, themselves, inconsistent, should be accorded less deference than those which 

are internally consistent’”) (quoting Murphy, 23 Cl. Ct. at 733)). Ultimately, a determination 

regarding a witness’s credibility is needed when determining the weight that such testimony should 

be afforded. Andreu, 569 F.3d at 1379; Bradley v. Sec’y of Health & Hum. Servs., 991 F.2d 1570, 

1575 (Fed. Cir. 1993).

When witness testimony is offered to overcome the presumption of accuracy afforded to 

contemporaneous medical records, such testimony must be “consistent, clear, cogent, and 

compelling.” Sanchez, 2013 WL 1880825, at *3 (citing Blutstein v. Sec’y of Health & Hum. Servs., 

No. 90-2808V, 1998 WL 408611, at *5 (Fed. Cl. Spec. Mstr. June 30, 1998)). In determining the 

accuracy and completeness of medical records, the Court of Federal Claims has listed four possible 

explanations for inconsistencies between contemporaneously created medical records and later 

testimony: (1) a person’s failure to recount to the medical professional everything that happened 

during the relevant time period; (2) the medical professional’s failure to document everything 

reported to her or him; (3) a person’s faulty recollection of the events when presenting testimony; 

or (4) a person’s purposeful recounting of symptoms that did not exist. Lalonde v. Sec’y of Health 

& Hum. Servs., 110 Fed. Cl. 184, 203-04 (2013), aff’d, 746 F.3d 1334 (Fed. Cir. 2014). In making 

a determination regarding whether to afford greater weight to contemporaneous medical records 

or other evidence, such as testimony at hearing, there must be evidence that this decision was the 
36

result of a rational determination. Burns, 3 F.3d at 417.

C. Analysis of Expert Testimony 

Establishing a sound and reliable medical theory often requires a petitioner to present 

expert testimony in support of his claim. Lampe v. Sec’y of Health & Hum. Servs., 219 F.3d 1357, 

1361 (Fed. Cir. 2000). Vaccine Program expert testimony is usually evaluated according to the 

factors for analyzing scientific reliability set forth in Daubert v. Merrell Dow Pharmaceuticals, 

Inc., 509 U.S. 579, 594–96 (1993). See Cedillo v. Sec’y of Health & Hum. Servs., 617 F.3d 1328, 

1339 (Fed. Cir. 2010) (citing Terran v. Sec’y of Health & Hum. Servs., 195 F.3d 1302, 1316 (Fed. 

Cir. 1999)). “The Daubert factors for analyzing the reliability of testimony are: (1) whether a 

theory or technique can be (and has been) tested; (2) whether the theory or technique has been 

subjected to peer review and publication; (3) whether there is a known or potential rate of error 

and whether there are standards for controlling the error; and (4) whether the theory or technique 

enjoys general acceptance within a relevant scientific community.” Terran, 195 F.3d at 1316 n.2 

(citing Daubert, 509 U.S. at 592–95).

The Daubert factors play a slightly different role in Vaccine Program cases than they do 

when applied in other federal judicial fora (such as the district courts). Daubert factors are usually 

employed by judges (in the performance of their evidentiary gatekeeper roles) to exclude evidence 

that is unreliable and/or could confuse a jury. In Vaccine Program cases, by contrast, these factors 

may be used in the weighing of the reliability of scientific evidence proffered. Davis v. Sec’y of 

Health & Hum. Servs., 94 Fed. Cl. 53, 66–67 (2010) (“uniquely in this Circuit, the Daubert factors 

have been employed also as an acceptable evidentiary-gauging tool with respect to persuasiveness 

of expert testimony already admitted”). The flexible use of the Daubert factors to evaluate the 

persuasiveness and reliability of expert testimony has routinely been upheld. See, e.g., Snyder, 88 

Fed. Cl. at 742–45. In this matter (as in numerous other Vaccine Program cases), Daubert has not 

been employed at the threshold, to determine what evidence should be admitted, but instead to 

determine whether expert testimony offered is reliable and/or persuasive.

Respondent frequently offers one or more experts of his own in order to rebut a petitioner’s 

case. Where both sides offer expert testimony, a special master’s decision may be “based on the 

credibility of the experts and the relative persuasiveness of their competing theories.” 

Broekelschen, 618 F.3d at 1347 (citing Lampe, 219 F.3d at 1362). However, nothing requires the 

acceptance of an expert’s conclusion “connected to existing data only by the ipse dixit of the 

expert,” especially if “there is simply too great an analytical gap between the data and the opinion 

proffered.” Snyder, 88 Fed. Cl. at 743 (quoting Gen. Elec. Co. v. Joiner, 522 U.S. 136, 146 (1997)); 

see also Isaac v. Sec’y of Health & Hum. Servs., No. 08-601V, 2012 WL 3609993, at *17 (Fed. 

Cl. Spec. Mstr. July 30, 2012), mot. for rev. denied, 108 Fed. Cl. 743 (2013), aff’d, 540 F. Appx. 

999 (Fed. Cir. 2013) (citing Cedillo, 617 F.3d at 1339). Weighing the relative persuasiveness of 
37

competing expert testimony, based on a particular expert’s credibility, is part of the overall 

reliability analysis to which special masters must subject expert testimony in Vaccine Program 

cases. Moberly, 592 F.3d at 1325–26 (“[a]ssessments as to the reliability of expert testimony often 

turn on credibility determinations”); see also Porter v. Sec’y of Health & Hum. Servs., 663 F.3d 

1242, 1250 (Fed. Cir. 2011) (“this court has unambiguously explained that special masters are 

expected to consider the credibility of expert witnesses in evaluating petitions for compensation 

under the Vaccine Act”).

Expert opinions based on unsupported facts may be given relatively little weight. See 

Dobrydnev v. Sec’y of Health & Hum. Servs., 556 F. Appx. 976, 992–93 (Fed. Cir. 2014) (“[a] 

doctor’s conclusion is only as good as the facts upon which it is based”) (citing Brooke Group Ltd. 

v. Brown & Williamson Tobacco Corp., 509 U.S. 209, 242 (1993) (“[w]hen an expert assumes 

facts that are not supported by a preponderance of the evidence, a finder of fact may properly reject 

the expert’s opinion”)). Expert opinions that fail to address or are at odds with contemporaneous 

medical records may therefore be less persuasive than those which correspond to such records. See 

Gerami v. Sec’y of Health & Hum. Servs., No. 12-442V, 2013 WL 5998109, at *4 (Fed. Cl. Spec. 

Mstr. Oct. 11, 2013), aff’d, 127 Fed. Cl. 299 (2014).

D. Consideration of Medical Literature 

Both parties filed numerous items of medical and scientific literature in this case, but not 

every filed item factors into the outcome of this Decision. While I have reviewed all the medical 

literature submitted in this case, I discuss only those articles that are most relevant to my 

determination and/or are central to Petitioners’ case—just as I have not exhaustively discussed 

every individual medical record filed. Moriarty v. Sec’y of Health & Hum. Servs., 844 F.3d 1322, 

1328 (Fed. Cir. 2016) (“[w]e generally presume that a special master considered the relevant record 

evidence even though he does not explicitly reference such evidence in his decision”) (citation 

omitted); see also Paterek v. Sec’y of Health & Hum. Servs., 527 F. Appx. 875, 884 (Fed. Cir. 

2013) (“[f]inding certain information not relevant does not lead to—and likely undermines—the 

conclusion that it was not considered”).

ANALYSIS

I. Threshold Issues Relevant to Diagnosis

A. D.C. Likely Experienced EPC

In many cases, application of the Althen causation test is appropriately dependent on first 

deciding if a petitioner’s claimed injury has preponderant support. Broekelschen, 618 F.3d at 1349.

Indeed, sometimes consideration of the Althen prongs is entirely unnecessaryonce it is determined 
38

that the asserted injury cannot be proven, since a claimant’s causal theory may completely rely on 

such a finding. Lombardi v. Sec’y of Health & Hum. Servs., 656 F.3d 1343, 1353 (Fed. Cir. 2011).

This is not such a case. Petitioners’ testifying treaters largely agreed that D.C. suffered 

from some form of epilepsy, likely EPC, and I find their views to be wholly consistent with the 

medical record. Accordingly, I will analyze Petitioners’ claim based on the determination that her 

injury was consistent with EPC.

In addition, I find there is record support, bulwarked by the testimony of treating physicians 

Drs. Van Haren and Sullivan, that D.C.’s epilepsy/seizures were more likely than not autoimmune 

in pathogenesis. This conclusion was reached by a large number of independent treaters who saw 

D.C. at different times (from Dr. Van Haren in the fall of 2014 to doctors at Boston Children’s 

Hospital in the spring of 2015). Some treaters may have rooted their conclusions in part on a 

mistaken connection between D.C.’s febrile seizure and her EPC (a connection Petitioners’ 

primary testifying expert, Dr. Steinman, expressly disavowed), but their views overall merit 

evidentiary weight. Respondent also reasonably observed that D.C. never tested positive for any 

specific autoantibodies associated with an autoimmune form of epilepsy, but that datapoint does 

not preclude a finding that her disease process was immune-driven. 

The proposed autoimmune character of D.C.’s injury gains some corroborative support 

from the fact that IVIG treatment was successful. Respondent reasonably pointed out a number of 

deficiencies with this contention, noting that such treatment is not a diagnostic criteria for 

autoimmune epilepsy/EPC, as well as the fact that IVIG can be beneficialsimply because it can 

reduce inflammation independently associated with epileptic seizures. But treaters directly 

responsible for D.C.’s care deemed the efficacy of this treatment as significant in identifying the 

underlying disease process’s pathologic nature, and again it is appropriate to give their conclusions 

some deference.

The record in this case does not, however, support the conclusion that D.C. had or has 

Rasmussen’s syndrome. D.C.’s overall progression and presentation is simply not consistent with 

that illness—which is unquestionably even more severe. Varadkar at 2-3. At best, treaters included 

it in diagnostic differentials because of D.C.’s focal seizure presentation—but the evidence over 

the total course of her treatment never confirmed it. And although both of D.C.’s testifying treaters 

(as well as Dr. Steinman) defended consideration of Rasmussen’s, none affirmatively testified that 

in fact this best characterized D.C.’s disease. See, e.g., Tr. at 226-29; Ex. 47. The diagnosis is not 

ultimately embraced in the medical record otherwise. This determination does not prevent a 

favorable entitlement finding, but it does mean that the comparison of D.C.’s course to 

Rasmussen’s, or analogies made between it and the causation theory proposed, are ultimately 

unhelpful in evaluating whether Petitioner has carried her burden of proof.
39

B. Program Treatment of Autoimmune Epilepsy Cases24

Vaccine Program petitioners have successfully established that different vaccines can

cause an autoimmune injury featuring or characterized by epileptic seizures. See, e.g.,Agarwal v. 

Sec’y of Health & Hum. Servs., No. 16-191V, 2020 WL 5651683 (Fed. Cl. Spec. Mstr. Aug. 31, 

2020) (child developed autoimmune limbic encephalitis (ALE) with intractable seizures after 

receiving Tdap and meningococcal vaccines); McCulloch v. Sec’y of Health & Hum. Servs., No. 

09-293V, 2015 WL 3640610 (Fed. Cl. Spec. Mstr. May 22, 2015) (human papillomavirus vaccine 

caused minor child to develop encephalitis, intractable epilepsy, and subsequent developmental 

delays). I note, however, that hardly any of these cases involve causation theories implicating the 

flu vaccine alone—and those that do are often readily distinguishable. See, e.g., Raybuck v. Sec’y 

of Health & Hum. Servs., No. 06-846V, 2010 WL 4860778 (Fed. Cl. Spec. Mstr. Nov. 9, 2010) 

(flu vaccine found to cause rash in child with preexisting seizure disorder; rash led to 

discontinuation of anti-convulsant medication, prompting exacerbation of child’s pre-existing 

epilepsy).

In addition, there is a significant factual element of this case separating it from many other 

cases (even involving the flu vaccine) in which damages have been awarded for epilepsy/seizures. 

Often, a petitioner can show that an injured child experienced a vaccine-induced fever, which then 

triggered a febrile seizure—thereby instigating an autoimmune form of epilepsy. See, e.g., Ginn v. 

Sec’y of Health & Hum. Servs., No. 16-1466V, 2021 WL 1558342 (Fed. Cl. Spec. Mstr. Mar. 26, 

2021) (five vaccines, including the flu vaccine, triggered a febrile seizure in four year-old that 

contributed/led to development of epilepsy); Tembenis v. Sec’y of Health & Hum. Servs., No. 03-

2820V, 2010 WL 5164324, at *15-16 (Fed. Cl. Spec. Mstr. Nov. 29, 2010) (febrile seizure 

attributable to DTaP vaccine caused epilepsy and death). In such cases, the vaccine’s causal 

contribution to subsequent disease flows directly from the impact of vaccination on a child’s 

innate/immediate immune response.

But in this case, Dr. Steinman—Petitioners’ primary causation expert—readily conceded 

that D.C.’s immediately post-vaccination febrile seizure had no relationship to her subsequent 

development of EPC, even if it had been directly caused by the flu vaccine (as he seemed to 

accept). Tr. at 211. Indeed, he admitted at hearing that his proposed causation theory (that a 

24 In reaching a decision in this case, I have considered other decisions issued by special masters (including my own) 

involving similar injuries, vaccines, or circumstances. There is no error in doing so. Although only Federal Circuit 

decisions control the outcome herein (Boatmon, 941 F.3d at 1358-59; Hanlon v. Sec’y of Health & Hum. Servs., 40 

Fed. Cl. 625, 630 (1998)), special masters reasonably draw upon their experience in resolving Vaccine Act claims. 

Doe v. Sec’y of Health & Hum. Servs., 76 Fed. Cl. 328, 338-39 (2007) (“[o]ne reason that proceedings are more 

expeditious in the hands of special masters is that the special masters have the expertise and experience to know the 

type of information that is most probative of a claim”) (emphasis added).They would therefore be remiss in ignoring 

prior cases presenting similar theories or factual circumstances, along with the reasoning employed in reaching such 

decisions.
40

molecular mimicry-driven cross-reaction instigated by the flu vaccine produced D.C.’s EPC) could 

not occur in such a short timeframe. Tr. at 213.

Thus, the question posed by this case is whether the flu vaccine could precipitate a disease 

process beginning approximately 10 to 14 days post-vaccination—not the same day as 

vaccination—and manifesting as eye twitching, but then evolving into outright focal, but afebrile,

seizures one to three monthslater.While there are some cases in which afebrile seizures have been 

linked to vaccination, they have mostly involved vaccines containing components (like pertussis 

toxin) thought to be seizure-provoking.25 Cases involving afebrile seizures have been less 

successful. See, e.g., K.L. v. Sec'y of Health & Hum. Servs., 134 Fed. Cl. 579, 587 (2017) (affirming 

special master’s determination that vaccine did not trigger afebrile seizure resulting in epilepsy); 

Dodd v. Sec'y of Health & Hum. Servs., 114 Fed. Cl. 43, 55–57 (2013) (special master's 

determination that evidence concerning febrile seizures had little bearing on alleged vaccine 

causation of afebrile seizures to be neither arbitrary nor capricious). 

II. Petitioners Have not Carried Their Burden of Proof

A. Althen Prong One

Dr. Steinman was the primary expert proposing the flu vaccine could cause EPC, as Drs. 

Sullivan and Van Haren disclaimed offering such an opinion. He reasoned as follows: (a) vaccines 

impact the immune system, (b) EPC can be an autoimmune condition, (c) vaccines can cause 

autoimmune diseases, (d) autoimmune processes can occur via the mechanism of molecular 

mimicry, and (e) homology (necessary to spark an autoimmune cross-reaction based on molecular 

mimicry) can be demonstrated between components of the flu vaccine and putative neuronal 

receptors in the brain reflective of the target of an autoimmune cross-reaction sufficient to initiate 

seizure activity. And he analogized the autoimmune process relevant herein to comparable 

autoimmune diseases involving intractable seizures, like Rasmussen’s, in which the immunemediated attack focuses on neuronal brain receptors (although my determination that the record 

does not establish that D.C. had Rasmussen’s limits greatly the value of such analogies).

While certain components of this casual theory do have reputable and reliable 

scientific/medical support, they do not add up to a causation theory that is more than speculative, 

as many links necessary for the conclusion that the flu vaccine could cause EPC are missing.

The core deficiency of Dr. Steinman’s opinion is the degree to which he relied almost 

wholly (by his own admission) on sequential homology to carry the day. He offered no evidence 

otherwise linking the flu vaccine to EPC—and Dr. McCusker cited to reliable epilepsy studies, 

like Kotloff, that cast doubt on any such vaccine association. Moreover, and unlike many Vaccine 

25 See, e.g., Andreu, 569 F.3d at 1380–81 (finding infant's seizures, which may have been afebrile, to be more likely 

than not caused by diphtheria-tetanus-whole cell pertussis vaccine); Almeida v. Sec'y of Health & Hum. Servs., No. 

96-412V, 1999 WL 1277566, at *3, *70 (Fed. Cl. Spec. Mstr. Dec. 20, 1999) (finding causation where petitioner 

experienced an afebrile seizure on the evening of the day she received a DPT vaccine).
41

Act cases, Dr. Steinman did not endeavor to identify case reports suggestive of a vaccine-EPC 

association—and while case reports are not viewed in the Vaccine Program as particularly 

probative of causation, as a class of evidence they still possess some limited value. Campbell v. 

Sec’y of Health & Hum. Servs., 97 Fed. Cl. 650, 668 (Fed. Cl. 2011) (case reports “do not purport 

to establish causation definitively, and this deficiency does indeed reduce their evidentiary value”); 

Cf. Contreras v. Sec’y of Health & Hum. Servs., 107 Fed. Cl. 280, 304 (2012) (finding that a 

special master’s decision to award case reports zero weight was contrary to authority).

Dr. Steinman therefore had to look elsewhere to substantiate his opinion, and did so by

focusing on molecular mimicry. He was able to show amino acid homology between the flu 

vaccine’s antigenic components and putative antigenic targets in the brain where an autoimmune 

form of epilepsy might occur (although this part of his argument lost some resonance to the degree 

to which it invoked Rasmussen’s—a disease the record does not suggest D.C. had). Moreover, 

molecular mimicry is unquestionably a reliable scientific theory for how autoimmune diseases can 

pathologically progress. Chinea v. Sec’y of Health & Hum. Servs., No. 15-095V, 2019 WL 

1873322, at *15 (Fed. Cl. Spec. Mstr. Mar. 15, 2019). But I have repeatedly noted that 

demonstration of homology alone is not enough to establish a preponderant causation theory.

Schultz v. Sec’y of Health & Hum. Servs., No. 16-539V, 2020 WL 1039161, at *22 n.24 (Fed. Cl. 

Spec. Mstr. Jan. 24, 2020) (“[m]ere demonstration of theoretical homology alone, based on 

computer-driven searches involving databases of amino acid sequences, does not carry the day”). 

The reasons that invocation of molecular mimicry (and a showing of homology as part of 

it) is insufficient to meet the “can cause” prong are many. As Dr. McCusker noted in rebutting Dr. 

Steinman’s opinion, homology is common in nature, and frequently exists without resulting in 

autoimmune injury, since the immune system usually is able to prevent an autoimmune crossreaction, or delete the immune cells that would likely specifically target self structures and 

proteins. She was also able to demonstrate, via the same kind of BLAST search performed by Dr. 

Steinman, that homology also exists between the neuronal receptors Dr. Steinman identified and 

other wild viruses common in children, but not considered associated with autoimmune forms of 

epilepsy. McCusker First Rep. at 5-9. Homology does not inexorably lead to disease.

As a result, to establish that a vaccine could prompt harm arising from a potential 

autoimmune cross-reaction that would occur due to homology, more is needed. 26Here, that “more” 

26 The rarity of vaccine injury, oft referenced by petitioners in justifying the causation showing theyattempt to make, 

does not excuse petitioners from their preponderant burden. It is well understood in the Program that entitlement 

determinations are made in a field “bereft” of direct evidence, and that the fact that vaccine injuries do not occur 

commonly does not mean they cannot occur(or cannot be proven with indirect evidence).Althen, 418 F.3d at 1280;

Capizzano, 440 F.3d at 1324 (“[I]n a field bereft of complete and direct proof of how vaccines affect the human body,” 

a paucity of medical literature supporting a particular theory of causationcannot serve as a bar to recovery” (emphasis 

added));see also Daubert, 509U.S. at 593 (“[I]n some instances well-grounded but innovative theories will not have 

been published.... Some propositions, moreover, are too particular, too new, or of too limited interest to be published”).

Indeed, the Program arises from the bedrock assumption that vaccines generally are safe—and that the public benefit 

of vaccination is served by a compensation system in which those rare individuals who are injured, and can prove the 

same, have redress. 
42

is absent—for the additional evidence filed in this case did not preponderantly support causation, 

and Dr. Steinman could not fill in these holes by citing to his own direct experience, either in 

researching the adverse effects of the flu vaccine or studying autoimmune forms of epilepsy.

Instead, Dr. Steinman’s argument borrowed neuronal receptors associated with other

autoimmune central nervous system injuries to propose how an autoimmune epilepsy would 

unfold. He in fact used these receptors to establish homology with the flu vaccine antigens. But 

those receptors are not typically implicated in T cell-mediated diseases, which Dr. Steinman 

unquestionably maintained was likely the character of D.C.’s epilepsy. McCusker Second Rep. at 

2-3. Indeed, D.C. did not even test positive for the autoantibodies associated with NMDA-R 

autoimmune illness. And Dr. Steinman’s opinion ignored Dr. McCusker’s point that a 

peripherally-administered vaccine could not be assumed to “beeline” for specific locations in the 

brain, especially since the vaccine’s antigens would have other comparably-homologous neuronal 

targets, in the brain as well as elsewhere in the body.

Dr. Steinman’s theory could have been supported with any number of different evidentiary 

items. He was certainly not required to marshal direct proof, or some specific type of evidence. 

But he could rest his opinion on speculation that an autoimmune disease process could flow from 

the theoretic possibility of an autoimmune cross-reaction. That is all demonstrating homology

accomplishes—and it does not constitute a preponderant showing. Were it otherwise, then 99 

percent of non-Table claimants could establish the “can cause” Althen prong, in any case involving 

an autoimmune disease, as long as they proved sequential homology via the testimony of a 

suitably-credentialed medical or scientific expert, and then demonstrated a temporal association 

between vaccine and injury. This would effectively relieve petitioners of their actual burden in 

non-Table cases, rendering the standard for assessing the “can cause” prong a simple factual 

determination, rather than a weighing process that takes into account the medical and scientific 

reliability of the individual components offered to support the theory in question.27

In addition to the above, Dr. Steinman’s theory faltered in other important regards. He 

opined that the disease process at issue was primarily propagated by cytotoxic T cells—making its 

pathogenesis distinguishable from illnesses in which a cross-reactive autoimmune attack due to 

Thus, the fact that cross-reactivity is not common (due perhaps to the general reasons invoked by Dr. McCusker) does 

not end the analysis and result in dismissal.But claimants must still meet their preponderant burden—and in off-Table 

cases, that burden is not insignificant. Hodges v. Secretary of Health & Hum. Servs., 9 F.3d 958, 961 (Fed.Cir.1993) 

(while “the [Vaccine Act] does the heavy lifting” when a claimant seeks to establish a Table injury, in the causationin-fact context “the heavy lifting must be done by the petitioner, and it is heavy indeed”).

27 Suggestions that this is in fact the proper standard to be applied in non-Table cases—based on the view that it is 

unfair to Vaccine Act claimants to have to address the scientific limits of their causation theories, given how little is 

known about how vaccines can injure individuals—have been succinctly criticized. See e.g., Boatmon, 941 F.3d at 

1363 (“[a]n unverified assertion of fact [regarding a causation theory] is not common sense; it is a non-cognizable 

argument. A statement of law without basis in statute or precedent is not sound reason”) (Wallach, J., concurrence).
43

molecular mimicry is mostly attributable to antibodies manufactured by B cells. See, e.g., Nibber. 

But as Dr. McCusker observed, a T cell-driven attack on self requires more than just a showing of 

initial sequential homology. Instead, it must be demonstrated that the cross-reacting T cells would 

recognize the self structure before concluding they could attack it. McCusker First Rep. at 5; 

McCusker Second Rep. at 3; Tr. at 296.

Such an evidentiary showing was not made—and Dr. Steinman’s pointing out that some T 

cells always play a role in antibody production(and hence will be involved even in antibody-driven 

autoimmune processes) seemed only intended to muddy the waters rather than meet head-on this 

deficiency in his causation theory, since the kinds of T cells that help the manufacture of antibodies

are distinguishable from those that Dr. Steinman posited were causal. Dr. Steinman similarly could 

not overcome Dr. McCusker’s persuasive showing that the flu vaccine was not even likely to 

upregulate the type of T cells he deemed central to the relevant disease process. McCusker First 

Rep. at 4. And (as noted above), Dr. Steinman unpersuasively analogized the autoimmune process 

herein to distinguishable disease processes understood to be B cell driven, borrowing receptors for 

his homology experiment like NMDA that cross-react with antibodies primarily rather than T cells. 

Tr. at 284; McCusker Second Rep. at 2-3.

I also note that after listening to both sides’ immunologic experts and reviewing the 

transcripts of their testimony, I gave far more weight to Dr. McCusker’s statements and opinions 

than to those of Dr. Steinman. Her testimony not only covered overarching weaknesses in 

Petitioners’ theory, but homed in on the individual elements of Dr. Steinman’s theory, and the 

views she expressed arose from her specific expertise in pediatric immunology. She persuasively 

rebutted the points made in favor of causation. Dr. Steinman, by contrast, placed far too much 

emphasis on molecular mimicry and homology in constructing a causation theory, ineffectively 

shielding his theory from challenge either by invoking the limits of science to understand the 

processes at issue, admitting outright that his opinion could not be better bulwarked, or 

acknowledging that he had simply fashioned an opinion that fit the facts of the case.28 Tr. at 262-

63. Other special masters have observed Dr. Steinman’s tendency when acting as a Program expert

to “shoehorn molecular mimicry into every causation in fact case” in which he testifies. See, e.g., 

D.G. v. Sec'y of Health & Hum. Servs., No. 11-577V, 2019 WL 2511769, at *189 (Fed. Cl. Spec. 

Mstr. May 24, 2019). That tendency was fully on display here, undermining his overall credibility.

In reaching the determination that Petitioners’ causation showing on the first Althen prong 

was inadequate, I am not requiring “scientific certainty,” and hence raising the evidentiary bar. 

Knudsen, 35 F.3d at 549. I well understand and accept that preponderance as an evidentiary 

standard inherently does not require certainty. Indeed, the fact that a claimant’s causal theory is 

found preponderant does not mean it is “scientifically certain” the vaccine can cause the relevant 

injury. Rather, it only signifies that the evidentiary weighing process performed by the special 

28 See footnote 13, above.
44

master (based on the collective probative value of several individual evidentiary items plus expert 

opinions) in the relevant case has resulted in a favorable determination. 

Similarly, the opposite determination—that a causation theory has notbeen preponderantly 

established—is not predicated on a special master’s unreasonable requiring of certainty. 

Petitioners may well offer several individual items of evidence (for example, molecular mimicry 

as a proposed autoimmunity mechanism) relevant to Althen prong one that are reliable or 

scientifically reputable. Yetthe totality of evidence, when weighed against Respondent’s showing, 

may not permit the special master to conclude causation is more likely than not. 

Here, it is my determination, after weighing the evidence and expert testimony, that Dr. 

Steinman’s causation theory over-relied on demonstrating sequence homology between 

components of the flu vaccine and certain neuronal receptors where focal seizures might occur, 

but without also proposing additional reliable evidence necessary to find that the flu vaccine could 

be associated with autoimmune epilepsy/EPC. Accordingly, I conclude that the preponderant 

“line” was not crossed.

B. Althen Prong Two

The facts of this case do not preponderantly support the conclusion that D.C.’s receipt of 

the flu vaccine was responsible for her EPC.

D.C. likely experienced a febrile seizure associated with her receipt of the flu vaccine that 

same day, despite the testimony of Respondent’s experts that this diagnosis lacked some 

evidentiary support. And yet—because Dr. Steinman disavowed the febrile seizure as having any 

relationship to D.C.’s later-diagnosed EPC, the vaccine’s causal relationship to a one-time febrile 

seizure has no bearing on entitlement in this case.

The medical record thereafter, however, does not suggest a relationship between 

vaccination and D.C.’s illness either.I accept the testimony of Petitioners and the other witnesses 

that D.C. began displaying eye fluttering in early February 2014, and that this fluttering was likely 

related to the EPC she was later diagnosed with, and thus the seizures that clinical evidence 

establishes she experienced in May that same year. Even though the medical record does not fully 

corroborate witness contentions about D.C.’s initial symptoms (and at best establishes symptoms 

onset later than alleged), it does not undermine them either—and relevant case law clearly permits 

Program claimants to establish these kinds of onset-related matters with individual sworn 

testimony, especially in the face of a silent or ambiguous record. Kirby v. Sec’y of Health & Hum. 

Servs., 997 F3d. 1378, 1382-83 (Fed. Cir. 2021).

However, Petitioners’ observations of initial outward manifestations of D.C.’s EPC do not 

establish that the flu vaccine harmed her. The record is far less supportive of such a contention.

Thus, D.C. never tested positive for any autoantibodies that would be associated with an 

autoimmune form of epilepsy—and while this fact may not have prevented treaters from 
45

confirming their ultimate diagnosis, it somewhat undercuts the conclusion that the flu vaccine 

caused it (although Dr. Steinman made reasonable points about how significant the presence of 

such autoantibodies would be—especially since he posited D.C.’s EPC was T cell-driven). In 

addition, treater support for the vaccine being causal is sparse, with no actual treaters opining “in 

real time” that the vaccine could have caused seizures that ultimately manifested months after 

vaccination. While admittedly Dr. Sullivan agreed that vaccination should be avoided for D.C. in 

August 2016, that treater advice seems more the product of caution on his part than a reliable 

determination that the vaccine was causal (as he admitted in his testimony). Ex. 10; Tr. at 200, 

206.

A larger issue inconsistent with the determination that the flu vaccine caused D.C.’s 

EPC/autoimmune epilepsy is the course of her illness from vaccination to manifestation of acute 

seizures. Having accepted Petitioners’ testimony plus Dr. Steinman’s view of symptoms onset, I 

have found that D.C.’s February 2014 eye fluttering was likely the start of some otherwiseundetected neurologic process that later progressed into outright focal seizures. But how is this 

course reflective of a disease process instigated by vaccination? Petitioners can only point to the 

fact that vaccination occurred first—and it is well known that a temporal association does not 

prove causation. Moberly, 592 F.3d at 1323. 

Dr. Steinman’s theory said much about how T cells might instigate harm, and attempted 

unsuccessfully to link this immunologic process to vaccination. But he similarly was unsuccessful 

in explaining how a flu vaccine might initiate a neurologic process that would take several months 

before becoming acute. He did not establish that the T cells he maintains would be increased due 

to an autoimmune cross-reaction instigated by molecular mimicry would first cause eye twitching 

that would later change into focal seizures. Indeed, he never effectively responded to Dr. 

McCusker’s contention that the flu vaccine would do a poor job of stimulating production of T 

cells in the first place.

C. Althen Prong Three

Because Petitioners’ showing on the first two Althen prongs was unsuccessful, determining 

Petitioners’ success in establishing the third prong is unnecessary. But although the timeframe 

prong was substantiated in part with reliable medical and scientific evidence, my reservations 

about the overall preponderant strength of evidence offered for it makes it difficult for me to 

conclude it was satisfied.

On the one hand, Petitioners marshaled preponderant evidentiary support for the 

conclusion that an autoimmune reaction to the flu vaccine, propagated by the adaptive arm of the 

immune system via the mechanism of molecular mimicry, could occur in a 10-20 day period. Here, 

this defines the approximate timeframe between D.C.’s January 2014 vaccination and onset of her 
46

eye blinking/fluttering in early February.29 Because that twitching was persuasively established to 

be likely associated with D.C.’s subsequent EPC/autoimmune epilepsy, the post-vaccination 

timeframe for onset was medically acceptable (assuming the inquiry focused only on that period).

On the other hand, Dr. Steinman did not persuasively establish that a vaccine-caused EPC 

would have a slowly progressive course after inception. Petitioners proposed autoimmune injury 

instigated by antigenic cross-reaction, but as Dr. McCusker noted, D.C.’s course (which features 

progression from eye fluttering to outright acute/focal seizures two to three months later) would 

reflect a “chipping away” process that is not consistent with how an immune-mediated injury

(dependent on the chronic production of T cells necessary to cause neurologic injury) would 

typically advance. Tr. at 313, 331. Dr. Steinman for his part seemed only to gesture to the contrary, 

offering little reliable evidence to support the contention that the flu vaccine could initiate such a 

lagging, slightly progressive process that would later become acutely/clinically evident, other than 

to maintain that immune memory sparked by the January 2014 vaccination would eventuallymake 

the process chronic. Tr. at 214. At bottom, the fact that the vaccine was not demonstrated to likely 

be associated with EPC moots the need to decide this prong—but I acknowledge the question was 

much closer here than in resolving the first two prongs.

CONCLUSION

The Caredios have suffered heart-breaking setbacks in their care of D.C., and have 

unquestionably struggled in the process. For this, they have my deepest admiration—and it would 

have been personally a great pleasure to award them compensation. But I am bound to apply the 

law correctly, and in this case Petitioners have not met their evidentiary burden. I therefore must 

dismiss the claim.

In the absence of a motion for review filed pursuant to RCFC Appendix B, the clerk of the 

court SHALL ENTER JUDGMENT in accordance with the terms of this decision.30

IT IS SO ORDERED. 

/s/ Brian H. Corcoran

 Brian H. Corcoran

 Chief Special Master

29 The record does contain some evidence that might suggest a pre-vaccination onset. See, e.g., Ex. 6 at 226–27, 244; 

Ex. 7 at 4-6 (records from May 29, 2014 neurologic evaluation); Ex. 12 at 12. However, this possibility was not fully 

fleshed-out at trial, nor did treaters ultimately propose or conclude that D.C.’s condition was so long in its 

development, and therefore I do not give weight to the point in evaluating the third Althenprong.

30 Pursuant to Vaccine Rule 11(a), the parties may expedite entry ofjudgment if (jointly or separately) they file notices 

renouncing their right to seek review.