Exhibit 10.10


 





Wuxi Yuanqing Tianmu Biological Technology
Co., Ltd.


 


No.:TMT-RD-XB-1610421


 


Strain Reconstruction 


 


Framework Cooperation Agreement


 




     


     


    

 


Party A: Gansu Qilianshan Pharmaceutical
Co., Ltd.


 


Party B: Wuxi Yuanqing Tianmu Biotechnology
Co., Ltd.


 


Date of signing: May 20, 2016


 


Party A: Gansu Qilianshan Pharmaceutical
Co., Ltd.


 


Address: No. 71, Jiujin East Road, Suzhou
District, Jiuquan City, Gansu Province


 


Zip code: 735000


 


Legal representative: Xin Zhanchang


 


Principal agent: Lu Bingyan 13893758013


 


Contact person: Xin Yichang


 


TEL:0937-2638043 13993738629


 


Email:785195924@qq.com


 




     


     


    

 


Party B: Wuxi Yuanqing Tianmu Biotechnology
Co., Ltd.


 


Address: 2nd Floor, Building A3, No. 777,
Jianshe West Road, Binhu District, Wuxi City


 


Zip code: 214072


 


Legal representative: Sui Peng


 


Principal agent:Liu Shuanshuan 18851589689


 


Contact person:Liu Shuanshuan


 


TEL:18851589689


 


Email:liushuanshuan@biobreeding.com


 


On the principle of equality and mutual
benefit, both parties have signed this agreement with the aim of transforming Streptomyces rimosus. and improving their production
efficiency through mutation, and both parties abide by and fulfill their obligations.


 


I.
Cooperative contents


 


1. Project name


 


Streptomyces rimosus
Reconstruction。


 


2. Project deadline


 


The specific implementation
of the project can be divided into three nodes: 6 months, 9 months, and 12 months.


 




     


     


    

 


The term of the project
begins on the date of finishing verification of the target of the starting strain.


 


3、Project completion goal


 


Oxytetracycline
fermentation unit increased Goal 1: by 10%; Goal 2: by 15%; Goal 3:by 20% (The
initial 120-ton tank level is 35,000 units/ml)


 


4、Fermentation level verification
method:


 


1) Initial level:The average
fermentation unit of the 120-ton fermenter with the starting strain of Streptomyces rimosus is 35,000 units/ml, which is subject
to the data verified by both parties.


 


2) Ways of verification:Based
on the actual production level of Party A's 120m3fermentation tank (average discharge level for 30 working days in a row)


 


3) The fermentation level verification
conditions are provided by Party A and are completed by both staff members. (Note: The travel and accommodation expenses of the
staff of both parties during the project implementation period are borne by both parties)


 


4) Each batch of verification samples
needs to be retained (including fermentation broth, intermediate sample and fermentation final sample, etc.); all parameters should
be recorded in each batch of sample fermentation process, including time, temperature, PH, etc.


 




     


     


    

 


5、cooperation mode


 


1) Party A provides the original
strain of streptomyces rimosus, and Party B is responsible for the whole process of strain modification.


 


2) After the completion of the project,
Party B will hand over to Party A a strain of streptomyces rimosus.


 


6、Research Achievement


 


1) All the research results obtained
by the streptomyces rimosus transformation project stipulated in this agreement (one mutant strain) are owned by Party A.


 


2) The intellectual property rights
related to the experimental schemes and methods applied in the streptomyces rimosus transformation process shall be jointly
owned by both parties, and both parties shall enjoy 50% of the rights. The patent application for the scientific research results
shall be jointly carried out by both parties.


 


3) If Party A uses the experimental
scheme and method of this project to transform other strains, Party A shall pay Party B the corresponding intellectual property
fees every year from the date of use, and the obtained research achievements shall be shared by both parties.


 


4) If Party B uses the experimental
scheme and method of this project to transform other strains, Party B shall pay Party A the corresponding intellectual property
fees every year from the date of use, and the obtained research achievements shall be shared by both parties.


 




     


     


    

 


5) Party A may also entrust Party
B to provide strain modification and related services continuously, and Party B shall give priority to Party A's project.。


 


7、project cost


 


1) Starting strain:a strain
of streptomyces rimosus provided by Party A.


 


2) Primary chemicals for experiments:


 


A Basic experimental reagents: provided
by Party B;


 


B Special medium for streptomyces rimosus:
provided by Party A。


 


Charge standard: Party B completes
the target 1, and after passing the acceptance of Party A, Party A pays RMB 1,000,000 (¥1000000.00) to Party B.;Party
B completes Target 2, and after passing the acceptance of Party A, Party A will pay another RMB 1,000,000 (¥1000000.00) yuan
to Party B;Party B completes Target 3, and after passing the acceptance of Party A, Party A will pay another RMB 1,000,000
(¥1000000.00) to Party B; Within 10 working days after the effective date of this agreement, Party A shall pay Party
B RMB 200,000 (¥200000.00) as the advance payment to achieve the target 1.


 




     


     


    

 


II.
The rights and obligations of both parties


 


1.Party A’s rights and obligations


 


1) Party A is responsible for providing
the strains of streptomyces rimosus. which are involved in the project, and providing Party B with real and effective strain information
related to this contract.


 


2) Party A is responsible for providing
the initial index of the strain of streptomyces rimosus (average fermentation unit 35,000 units/ml) which should be confirmed by
Party B.


 


3) Party A shall pay the target amount
of each period on time according to the agreement.。


 


4) Party A has the right to supervise
the progress of the project.


 


5) Party A shall promptly negotiate
with Party B if there is any change in the content of the agreement.


 


6) During the performance of the
contract, if Party A unilaterally proposes to terminate this contract, Party B shall not refund the fees already paid by Party
A, and Party B has the right to recover the costs of the completed results from Party A.


 


2.Party B’s rights and obligations


 


1) Party B completes the transformation
of streptomyces rimosus according to the requirements of the agreement.


 


2) Party
B is responsible for the feasibility study of the technical route of the streptomyces rimosus reconstruction project, the formulation
of the transformation plan, the provision of research and development environment and R&D personnel.


 




     


     


    

 


3) Party B shall strictly maintain
the confidentiality of the information of the streptomyces rimosus in accordance with the requirements of the agreement.


 


4) Party B is responsible for providing
online real-time video surveillance to Party A. All experiments and reconstruction work of Party B on Party A's strain must be
carried out in Party A's video surveillance area. Party B shall not take the strain and related waste liquid or other waste away
from the video surveillance area. All waste and waste liquid must be inactivated in the video surveillance area or under the supervision
of Party A.


 


5) Party B shall provide the corresponding
research and development results for Party A's acceptance according to the time node specified in the agreement. The acceptance
criteria shall be based on Party A's 30-day average fermentation unit (pot release unit) data.


 


6) If the project meets the agreed
objectives of this contract, Party B shall, after receiving the fees payable by Party A, transfer the designated strains, experimental
materials and other relevant materials related to the project to Party A and destroy the relevant waste liquid and other waste
under the supervision of Party A


 


7) If the project does not reach
the target 1 in the end, Party B shall refund the full prepaid project fee of RMB 200,000 (¥200000.00) and the designated strains
and experimental data of the project to Party A within 10 working days. After the related waste liquids and other waste are destroyed
under the supervision of Party A, the contract terminates on its own.


 




     


     


    

 


8) During the performance of the
contract, if Party B unilaterally proposes to terminate this contract, Party B shall compensate Party A in accordance with the
double payment of Party A’s expenses.


 


III.
Project Changes


 


In the event of any major changes in the
project, Party A and Party B shall sign a supplementary agreement.


 


IV.Payment
Methods


 


1. Within 10 working days after the effective
date of this agreement, Party A shall pay Party B a total of RMB 200,000 (¥200000.00) as the advance payment to achieve the
objective1.


 


2. Within 30 working days after each objective
has been reached and passed the acceptance check of Party A, Party A shall pay Party B the corresponding target amount.


 


3. Payment method is by bank transfer or
check transfer.


 




     


     


    

 


V.
Confidentiality clause


 


Party A and Party B shall not disclose
any information or materials provided by the other party to a third party for any reason, form or purpose without the permission
of the other party, otherwise Party B shall bear the corresponding legal responsibility and compensate for the losses.


 


1. Confidential information of Party
A


 


1) The original strain of Streptomyces
rimosus involved in this project.


 


2) Basic information on Streptomyces rimosus,
including strain name and classification and number, source, usage, etc.


 


3) Research results of the project.


 


	COMPANY NAME	Wuxi Yuanqing Tianmu Biotechnology Co. Ltd.
	
        Bank of Deposit
	Wuxi Binhu Subbranch of China Construction Bank Co. Ltd.
	Account Number	3200 1614 8360 5251 5485
	Tax Registration Number	3202 0031 3737 185
	Telephone	0510-81193033
	Address	No.777 A3, 2nd floor, Binhu District, Wuxi 


 


2. Confidential information of Party
B


 


1)Experimental scheme and method for transformation
of Streptomyces rimosus.


 


2) Documents signed during project implementation.


 




     


     


    

 


3) Research results of the project.


 


3. Other terms


 


1) Both Party A and Party B shall take
appropriate measures to properly preserve the confidential information provided by the other party, which shall be no less prudent
than when it protects its own confidential information.


 


2) Both parties guarantee that confidential
information will only be known within the scope of the person in charge of the business and the relevant team of each party. Before
both parties are aware of the confidential information, they shall be reminded of the confidentiality and obligations of the confidential
information, and shall demonstrate in a verifiable manner that the above-mentioned persons are indeed responsible for the confidentiality
under this Agreement.


 


3) For information that has been published
by both parties, it is not subject to this confidentiality clause.


 


4) If there is no special indication or
otherwise agreement, the information confidentiality period is 5 years.


 


5) In order to protect the rights and interests
of Party A, Party B shall not engage in any research and development project similar to this project (same kind of bacteria and
products) within one year after the completion or termination of this contract.


 




     


     


    

 


VI.
Liability for breach of contract


 


1. Any failure by either party to fulfill
the terms of this Agreement is considered as a breach of contract. The party that committed the breach shall bear the loss caused
to the other party due to his own breach of contract.


 


2. Once the compliance party finds that
the other party has breached the contract, it should promptly communicate with the other party and remind the other party to correct,
remedy or make reasonable claim for compensation.


 


3. A compliance party shall have the right
to take injunctions, actual performance or other reasonable remedies if it is not sufficient to provide compensation for a breach
of this agreement.


 


4. In case Party B breaches the provisions
of this agreement, Party B shall pay to Party A at least twice of the total amount of this contract, if Party B takes Party A's
strains, wastes and waste liquids out of the video surveillance area or fails to deactivate them as required by Party A. In case
of causing other losses, Party A reserves the right to recover liability of Party B.


 


5. Party B (including the personnel of
Party B participating in the project) shall not transfer Party A's strains and its transformation results to a third party. Otherwise,
Party B shall pay Party A a minimum of ten times the contract amount as a breach of contract damages. At the same time, Party A
reserves the right to recover economic loss from Party B.


 




     


     


    

 


6. The total amount of the contract referred
to in this Article is determined as follows/:


 


1) If the project achieves objective 1,
the total contract amount is calculated at RMB 1 million Yuan;


 


2) If the project achieves objective two,
the total contract amount is calculated at RMB 2 million Yuan.


 


3) If the project achieves objective three,
the total contract amount is calculated at RMB 3 million Yuan.


 


VII.
SETTLEMENT OF DISPUTES


 


This Agreement shall be governed by and
construed in accordance with the laws of the People's Republic of China (hereinafter referred to as "China") Any dispute
arising out of or in connection with the performance or interpretation of this Agreement shall be arbitrated by Arbitration Commission
of Jiayuguan City and under the jurisdiction of the People's Court of Party B at the place where Party B is located, if no settlement
can be reached through consultation between the two parties.


 


VIII.
MISCELLANEOUS 


 


1. This Agreement shall take effect upon
the date of signing.


 




     


     


    

 


2. All content covered by this Agreement
may not be transferred to a third party without the written consent of the other party.


 


3. Due to force majeure events which may
be unforeseen, unavoidable and insurmountable, the two parties are not responsible for each other when the agreement cannot be
performed normally.


 


4. Party A and Party B shall perform this
Agreement in good faith and trustworthiness. This agreement is executed in two copies and each party holds one respectively.


 


5. Any issues not mentioned in this agreement
shall be settled by both parties through negotiation in accordance with relevant regulations.


 


Party A (seal): Gansu Qilianshan Pharmaceutical
Co.Ltd.


 


Authorized representative (signature)


 


Date: May 20, 2016


 


Party B (seal): Wuxi Yuanqing Tianmu Biotechnology
Co. Ltd.


 


Authorized representative (signature)


 


Date: May 24, 2016