### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 1 of 14 

## UNITED STATES ENVIRONMENTA L PROTECTION A GENCY

WASHINGTON, D.C. 20460 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES



## MEM ORANDUM Date: 27 October 2009 SUBJECT: Clopyralid – Acute and Chronic Combined Dietary (Food + Drinking Water) Exposure and Risk Assessment s to Evaluate New Uses on Swiss Chard, Strawberry , and Bushberry (Subgroup 13 - 07B). PC Code: 117401 (salt)

117403 (acid) DP Barcode: D 36 8855 Decision No.: 403248 Registration Nos. : 62719 - 80, 62719 - 81, and 62719 - 84 Petition No.: 8E7481 Regulatory Action: Section 3 and 24(c) Registrations Risk Assessment Type: Dietary (Single chemical) Case No.: NA T XR No.: NA CAS Nos.: 1702 - 17 - 6 (acid) 5774 - 85 - 5 (monoethanolamine salt) MRID No.: None 40 CFR: 180.431 

## FROM : Michael A. Dohert y, Ph.D., Chemist

Risk Assessment Branch II Health Effects Division (7509P) THROUGH: William Cutchin, Chemist

Donna Davis, Chemist Dietary Exposure Science Advisory Council (DESAC) Health Effects Division (7509P) Richard A. Loranger, Ph.D., Senior Scientist Risk Assessment Branch II Health Effects Division (7509P) TO: Michael A. Dohert y, Ph. D., Chemist

Risk Assessment Branch II Health Effects Division (7509P) Barbara Madden, RM 05 Risk Integration, Minor Use & Emergency Response Branch Registration Division (7505P)

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 2 of 14 

## Executive Summary Acute and chronic combined die tary ( food + drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model DEEM - FCIDTM, Version 2.03 which use food consumption data from the U.S. Department of Agriculture’s Continuing Survey s of Food Intakes by

I ndividuals (CSFII) from 1994 - 1996 and 1998. T he analyses w ere performed to support Section 3 and Section 24(c) requests for uses on swiss chard, bushberry Subgroup 13 - 07B, and strawberry . The acute and chronic assessments are highl y conservative with reg ard to protecting human health. Both assessments assume 100% crop treated and are based on tolerance - level residues for all commodities. Modeled estimates of clop yr alid residues in drinking water have been incorporated into the analy ses. Children 1 - 2 y e ars old are estimated to have the highest dietary exposure to clopy

ralid. T he screening - level estimates for that subpopulation are 9% of the acute population - adjusted dose (aPAD ) and 24% of the chronic population - adjusted dose (cPAD) . Generally , HED is c oncerned about dietary risk when the exposure estimate exceeds 100% of the PAD. Therefore, the combined dietary risk from residues of clop yr alid in food and drinking water are below HED’s level of concern for all population groups. There are no dietary e xposure considerations that would preclude granting the requested uses of clopy ralid. An aggregate human health risk assessment is forthcoming (DP No. D361316). I. Introduction Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population ad justed dose (PAD). The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertaint y or safet y factors. For acute and non - cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is generall y concerned when estimated cancer risk exceeds one in one million. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exp osure from Pesticides, A User’s Guide,” 21 - JUN - 2000, web link: http://www.epa.gov/fedrgstr/EPA PEST/2000/July

/Day - 12/6061.pdf ; or see SOP 99.6 (20 - AUG - 1999). The most rece nt dietary

risk assessment for clop yr alid was conducted b y D. Dotson ( 9 Sept 2002 , D 284780 ). II. Residue Information Permanent tolerances are established for residues of clopy ralid in/on a wide variet y of plant commodities at levels ranging from 0.5 ppm in/on stone fruits to 500 ppm in/on grass forage and hay [40 CFR §180.431(a)], including a tolerance of 1.0 ppm for strawberry . Permanent

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 3 of 14 

## tolerances are also established for residues of clopy ralid in livestock commodities at levels ranging from 0.1 ppm in eggs to 36 ppm in meat byproducts, except liver, of cattle, goats, horses and sheep . The residue of concern for both tolerance enforcement and risk assessment is the parent compound onl y. To support the petitioned - for uses, IR - 4 has submitted residue data f rom field trials with swiss chard, blueberry , and strawberry (depicting residues following the annual production practice associated with the regional registration request). HED’s recommended tolerances for these uses, derived from th e NAFTA tolerance - harmonization spreadsheet, are 3.0 ppm for swiss chard, 0.5 ppm for the bushberry subgroup, and 4.0 ppm for strawberry . HED is recommending that the 4.0 - ppm tolerance for strawberry replace the existing 1.0 - ppm tolerance. Furthermore, HED is recommendin g that the existing tolerance of 4.0 ppm for cranberry remain in place, despite the fact that cranberry is a member of Crop Subgroup 13 - 07B. This is due to differences in the use directions for cranberry versus those for the subgroup in general. These re quested uses do not impact existing tolerances for livestock commodities. This is a screening - level assessment; therefore, tolerance - level residues were used in the anal ys es along with default processing factors from DEEM version 7.81. It was also assume d that 100% of crops with registered or requested uses of clop yralid were treated. The inputs for the dietary assessments are provided in Attachments 1 (acute assessment) and 2 (chronic assessment). III. Drinking Water Data The estimated drinking water conc entrations (EDWCs) used in the dietary risk assessment were provided b y the Environmental Fate and Effects Division (EFED) in the following memorandum: “Tier I Drinking Water Assessment for Proposed New Use of Clopyralid on Swiss Chard, Bushberry

Subgroup 13 - 07B and Annual Strawberry ” (A. Shelby , 9 September 2009, D361314) and incorporated directl y into this dietary assessment. Water residues were incorporated in the DEEM - FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” Modeled estimates of surface water from the FIRST model were used for both the acute and chronic assessments (Table 1) . These estimates are greater than those for groundwater via the SCI GROW model as well as the monitoring data that are avai lable for clopy ralid. The models and their descriptions are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/ . Table 1. Estimated Drinking Water Concentrations for Clopyralid. Drinking Water Source (Model Used) Use (Rate Modeled) Maximum Estimated Drinking Water Concentration (E DWC ) , ppb Groundwater (S CIGROW ) Bushberry (0.25 Lbs a.i ./A) Ac ute And Chronic 0.39 Groundwater (Monitoring) NAWQA (Alabama) Ac ute 13 Surf ace Water (F IRST ) Bushberry (0.25 Lbs a.i ./A) Ac ute 41.1 Bushberry (0.25 Lbs a.i ./A) Chronic 10.8 Non - crop (0.5 lb a.i./A) Ac ute 45.0 Non - crop (0.5 lb a.i./A) Chronic 11.9 Surface Water (Monitoring) NAWQA Ac ute 42

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 4 of 14 

## For these assessments, the maximum E DWCs of 45 ppm (acute) and 11.9 ppm (chronic) were used. As noted in EFED’s evaluation, the monitoring data are greater than some of the modeled estimates; especiall y for groundwater. HED believes that using the modeled estimates in the dietary assess ment is protective of human health since modeled values are the maxima for their respective exposure durations. IV. DEEM - FCIDTM Program and Consumption Information Clopy ralid acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity I ntake Database DEEM FCIDTM, Version 2.03 which incorporates consumption data from USDA’s Continuing Survey s of Food Intakes b y Individuals (CSFII), 1994 - 1996 and 1998. The 1994 - 96, 98 data are ba sed on the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on anal ys is of the 1994 - 96, 98 CSFII consumption data, which took into account dietary

patterns and survey

respondents, HED concluded that it is most appropriate to report ris k for the following population subgroups: the general U.S. population, all infants (<1 ye ar old), children 1 - 2, children 3 - 5, children 6 - 12, y outh 13 - 19, adults 20 - 49, females 13 - 49, and adults 50+ years old. For chronic dietary

exposure assessment, an es timate of the residue level in each food or food form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting res idue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg bod y weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. For acute exposure assessments, individual one - day food consumption data are used on an individual - by - individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resu lting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who reported eating relevant commodities/food forms) and a per - capita (i.e., those who reported eating the relevant commodities as well as those who d id not) basis. In accordance with HED policy , per capita exposure and risk are reported for all tiers of anal ysis. However, for tiers 1 and 2, an y significant differences in user vs. per capita exposure and risk are specificall y identified and noted in the risk assessment.

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 5 of 14 

## V. Toxicological Information The toxicology

database for clopy

ralid is incomplete at this time. Based on the toxicology data requirements outlined in the recently revised 40 CFR Part 158, there are additional requirements for acut e and subchronic neurotoxicity studies in the rat (§870.6200a and b), and an immunotoxicity

study (§870.7800). In addition, a 28 - day inhalation toxicity

study in the rat (§870.3465) is required. Nevertheless, HED recommends reduction of the FQPA special factor to 1x. There was no evidence of increased pre - and/or postnatal qualitative or quantitative susceptibility

in the developmental rat or rabbit studies, or the rat 2 - generation reproduction study . In the developmental rat study , no developmental eff ects were seen in at a dose that caused maternal toxicity . Although acute and subchronic neurotoxicity studies and an immunotoxicity

study have not been submitted and are required under the revised 40 CFR Part 158 guidelines, the available subchronic and chronic studies show no evidence of either neurotoxicity

or immunotoxicity

at doses up to or exceeding the limit dose. The endpoints selected for risk assessment are therefore considered adequatel y protective of pre - and/or postnatal toxicity . The endpoi nts for use in dietary risk assessment are summarized in Table 2, below. Table 2. Toxicological Doses and Endpoints for Clopyralid for Use Dietary and Residential Hum an Health Risk Assessments. Exposure/ Scenario Point of

Departure Uncertainty/FQPA

Saf ety Factors Level of Concern for

Risk Assessment Study and Toxicological Effects Ac ute Dietary (All populations including infants and children) NOAEL =

75 mg/kg UF A

### = 10x

UF H 

### = 10x SF FQPA

### =1 aRfD=

0.75 mg/kg/day aPAD= 0.75 mg/kg/day Developmental Toxicity (oral)

– rat

Maternal LOAEL = 250 mg/kg/day, based on decreased body weight gain and food consumption during GD 6 - 9. Chronic Dietary ( All populations including infants and children) NOAEL=

15 mg/kg/day UF A

### = 10x

UF H 

### = 10x SF FQPA

### =1 cRfD=

0.15 mg/kg/day cPAD= 0.15 mg/kg/day 2 - Year Combined Chronic

Toxicity/Carcinogenicity (oral)

– rat LOAEL = 150 mg/kg/day, based on increased epithelial hyperplasia and thickening of the limiting ridge of the stomach in both sexes. Cancer Classified as “Not likely to be carcinogenic to humans”. Quantification of cancer risk is not

required. Point of Departure (POD) = A data point or an estimated point that is derived from observed dose - response data and used to mark the beginning of extrapolation to determine risk ass ociated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A 

### = extrapolation from animal to human (interspecies). UF H 

### = potential vari ation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. MOE = margin of exposure. LOC = level of concern. N/A = not applic able. 

## VI. Results As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM - FCIDTM anal ys es estimate the dietary exposure of the U.S. population and various population subgroups. The result s reported in Table 3 are for the general U.S. Population, all infants (<1 y ear old), children 1 - 2, children 3 - 5, children 6 - 12, y outh 13 - 19,

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 6 of 14 

## females 13 - 49, adults 20 - 49, and adults 50+ years. Risk estimates are below HED’s level of concern for all population subgroups. Table 3 . Summary of the Combined Dietary (Food + Drinking Water) Exposure and Risk Estimates for Clopyralid. Population Subgroup Ac ute ( 95th Percentile) Chronic Cancer Dietary Exposure (m g/kg/day) %

aPAD* Dietary Exposure

(m g/kg/day) % cPAD* Dietary Exposure (m g/kg/day) Risk General U.S. Population 0.035084 5 0.013212 9 N/A N/A All Infants (< 1 year old) 0.043768 6 0.012778 9 Children 1 - 2 years old 0.070616 9 0.035056 23 Children 3 - 5 y ears old 0.060428 8 0.031908 21 Children 6 - 12 y ears old 0.042390 6 0.021317 14 Youth 13 - 19 y ears old 0.025842 3 0.012669 8 Ad ults 20 - 49 y ears old 0.022783 3 0.010403 7 Ad ults 50+ years old 0.019576 3 0.008967 6 Fem ales 13 - 49 y ears old 0.021362 3 0.009685 7 * %PADs are reported to 2 significant figures. The values for the highest exposed population for each type of risk assessment are bolded . 

## VII. Characterization of Inputs/Outputs Highl y conservative, health - protective assumptions have been used throughout the acute and chronic d ietary

assessments for clop yralid. The resulting exposure and risk estimates likely overestimate an y actual dietary exposures to clopyralid that may occur due to the registered and requested uses. VIII. Conclusions Highl y conservative assessments indicate that there are no acute or chronic dietary (food + drinking water) exposure concerns for clop yr alid. There are no dietary risk considerations that would preclude granting the requested uses. A full aggregate human health risk assessment is forthcoming (D 361316). IX. List of Attachments Attachment 1. Inputs for the acute dietary exposure assessment of clopy ralid Attachment 2. Inputs for the chronic dietary exposure assessment of clopyralid. Attachment 3. Summary of the acute dietary exposure and ri sk estimates for clopy ralid. Attachment 4. Summary of the chronic dietary exposure and risk estimates for clop yralid.

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 7 of 14 

## Attachment 1. Inputs for the acute dietary exposure assessment of clopy ralid U.S. Environmental Protection Agency Ver. 2.02 DEEM - FCID Acute analysis for CLOPYRALID Residue file name: C: \ Documents and Settings \ mdoherty \ My Documents \ Chemistry Reviews \ Clopyralid \ 2009 \ 117403 - 2009 Acute.R98 Analysis Date 09 - 22 - 2009 Residue file dated: 09 - 22 - 2009/0 9:31:12/8 Reference dose: aRfD = 0.75 mg/kg bw/day NOEL = 75 mg/kg bw/day

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Foo d Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 12000120 12 Apricot 0.500000 1.000 1.0001E6239 12000121 12 Apricot - babyfood 0.500000 1.000 1.0001E6239 12000130 12 Apricot, dried 0.500000 6.000 1.0001E6239 12000140 12 Apricot, juice 0.500000 1.000 1.0001E6239 12000141 12 Apricot, juice - babyfood 0.500000 1.000 1.0001E6239 95000190 O Asparagus 1.000000 1.000 1.0001E3979 15000250 15 Barley, pearled barley 3.000000 1.000 1.0004F3054 15000251 15 Barley, pearled barley - babyfood 3.000000 1.000 1.0004F3054 15000260 15 Barley, flour 3.000000 1.000 1.0004F3054 15000261 15 Barley, flour - babyfood 3.000000 1.000 1.0004F3054 15000270 15 Barley, bran 12.000000 1.000 1.0004F3054 21000440 M Beef , meat 1.000000 1.000 1.0001F2439 21000441 M Beef, meat - babyfood 1.000000 1.000 1.0001F2439 21000450 M Beef, meat, dried 1.000000 1.920 1.0001F2439 21000460 M Beef, meat byproducts 36.000000 1.000 1.0001F2439 21000461 M Beef, meat byproducts - babyfood 36.000000 1.000 1.0001F2439 21000470 M Beef, fat 1.000000 1.000 1.0001F2439 21000471 M Beef,fat - babyfood 1.00000 0 1.000 1.0001F2439 21000480 M Beef, kidney 36.000000 1.000 1.0001F2439 21000490 M Beef, liver 3.000000 1.000 1.0001F2439 21000491 M Beef, liver - babyfood 3.000000 1.000 1.0001F2 439 01010500 1AB Beet, garden, roots 4.000000 1.000 1.0001E6333 01010501 1AB Beet, garden, roots - babyfood 4.000000 1.000 1.0001E6333 02000510 2 Beet, garden, tops 3.000000 1.000 1.0001E6333 01010520 1A B eet, sugar 2.000000 0.100 1.0008F3600 01010521 1A Beet, sugar - babyfood 2.000000 0.100 1.0008F3600 01010530 1A Beet, sugar, molasses 10.000000 1.000 1.0008F3600 01010531 1A Beet, sugar, molasse s - babyfood 10.000000 1.000 1.0008F3600 13020570 13B Blueberry 0.500000 1.000 1.0008E7481 13020571 13B Blueberry - babyfood 0.500000 1.000 1.0008E7481 05010610 5A Broccoli 2.00 0000 1.000 1.0001E3999 05010611 5A Broccoli - babyfood 2.000000 1.000 1.0001E3999 05010620 5A Broccoli, Chinese 2.000000 1.000 1.0001E3999 05010640 5A Brussels sprouts 2.000000 1.000 1.000 1E3999 05010690 5A Cabbage 2.000000 1.000 1.0001E3999 05010710 5A Cabbage, Chinese, napa 2.000000 1.000 1.0001E3999 05010720 5A Cabbage, Chinese, mustard 2.000000 1.000 1.0001E3999 05010830 5A Cauliflower 2.000000 1.000 1.0001E3999 12000900 12 Cherry 0.500000 1.000 1.0001E6329 12000901 12 Cherry - babyfood 0.500000 1.000 1.0001E6329 12000910 12 Cherry, juice 0.500000 1.500 1.0001E6329 12000911 12 Cherry, juice - babyfood 0.500000 1.500 1.0001E6329 40000930 P Chicken, meat 0.200000 1.000 1.0004F3054 40000931 P Chicken, meat - babyfood 0 .200000 1.000 1.0004F3054 40000940 P Chicken, liver 0.200000 1.000 1.0004F3054 40000950 P Chicken, meat byproducts 0.200000 1.000 1.0004F3054 40000951 P Chicken, meat byproducts - babyfoo 0.200000 1.000 1. 0004F3054 40000960 P Chicken, fat 0.200000 1.000 1.0004F3054 40000961 P Chicken, fat - babyfood 0.200000 1.000 1.0004F3054 40000970 P Chicken, skin 0.200000 1.000 1.0004F3054 40000971 P Chicken, skin - babyfood 0.200000 1.000 1.0004F3054 15001200 15 Corn, field, flour 1.000000 1.000 1.0004F4379 15001201 15 Corn, field, flour - babyfood 1.000000 1.000 1.0004F4379 15001210 15 Corn, field, m eal 1.000000 1.000 1.0004F4379 15001220 15 Corn, field, bran 1.000000 1.000 1.0004F4379 15001230 15 Corn, field, starch 1.000000 1.000 1.0004F4379 15001231 15 Corn, field, starch - babyfood 1.000000 1.000 1.0004F4379 15001240 15 Corn, field, syrup 1.000000 1.500 1.0004F4379

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 8 of 14 15001241 15 Corn, field, syrup - babyfood 1.000000 1.500 1.0004F4379 15001250 15 Corn, field, oil 1.000000 1.000 1.0004F4379 15001251 15 Corn, field, oil - babyfood 1.000000 1.000 1.0004F4379 15001260 15 Corn, pop 1.000000 1.000 1.0004F4379 15001270 15 Corn, sweet 1.000000 1.000 1.0004F4379 150012 71 15 Corn, sweet - babyfood 1.000000 1.000 1.0004F4379 95001300 O Cranberry 4.000000 1.000 1.0001E6340 95001301 O Cranberry - babyfood 4.000000 1.000 1.0001E6340 95001310 O Cranberry, dried 4.000000 4.000 1.0001E6340

Full comment: 1E6340 Conc. factor from cherry 95001320 O Cranberry, juice 4.000000 1.100 1.0001E6340 95001321 O Cranberry, juice - babyfood 4.000000 1.100 1.0001E6340 13021360 13B Currant 0.500000 1.000 1.0008E7481 70001450 P Egg, whole 0.100000 1.000 1.0004F3054 70001451 P Egg, whole - babyfood 0.100000 1.000 1.0004F3054 7000146 0 P Egg, white 0.100000 1.000 1.0004F3054 70001461 P Egg, white (solids) - babyfood 0.100000 1.000 1.0004F3054 70001470 P Egg, yolk 0.100000 1.000 1.0004F3054 70001471 P Egg, yolk - ba byfood 0.100000 1.000 1.0004F3054 13021490 13B Elderberry 0.500000 1.000 1.0008E7481 20001630 20 Flaxseed, oil 3.000000 1.000 1.0001E6227 23001690 M Goat, meat 1.000000 1.000 1.0001F2439 23001700 M Goat, meat byproducts 36.000000 1.000 1.0001F2439 23001710 M Goat, fat 1.000000 1.000 1.0001F2439 23001720 M Goat, kidney 36.000000 1.00 0 1.0001F2439 23001730 M Goat, liver 3.000000 1.000 1.0001F2439 13021740 13B Gooseberry 0.500000 1.000 1.0008E7481 95001880 O Hop 5.000000 1.000 1.0001E6283 2400 1890 M Horse, meat 1.000000 1.000 1.0001F2439 13021910 13B Huckleberry 0.500000 1.000 1.0008E7481 05011960 5A Kohlrabi 2.000000 1.000 1.0001E3999 28002210 M Meat, gam e 1.000000 1.000 1.0001F2439 27002220 D Milk, fat 0.200000 1.000 1.0001F2439 27002221 D Milk, fat - baby food/infant for 0.200000 1.000 1.0001F2439 27012230 D Milk, nonfat solids 0.200000 1.000 1.0001F2439 27012231 D Milk, nonfat solids - baby food/in 0.200000 1.000 1.0001F2439 27022240 D Milk, water 0.200000 1.000 1.0001F2439 27022241 D Milk, water - babyfood/infant form 0.200000 1 .000 1.0001F2439 27032251 D Milk, sugar (lactose) - baby food/ 0.200000 1.000 1.0001F2439 05022290 5B Mustard greens 5.000000 1.000 1.0001E6334 12002300 12 Nectarine 0.500000 1.000 1.0001E6329 1 5002310 15 Oat, bran 3.000000 1.000 1.0004F3054 15002320 15 Oat, flour 3.000000 1.000 1.0004F3054 15002321 15 Oat, flour - babyfood 3.000000 1.000 1.0004F3054 15002330 15 Oat, g roats/rolled oats 3.000000 1.000 1.0004F3054 15002331 15 Oat, groats/rolled oats - babyfood 3.000000 1.000 1.0004F3054 12002600 12 Peach 0.500000 1.000 1.0001E6329 12002601 12 Peach - babyfood 0.500000 1.000 1.0001E6329 12002610 12 Peach, dried 0.500000 7.000 1.0001E6329 12002611 12 Peach, dried - babyfood 0.500000 1.000 1.0001E6329 12002620 12 Peach, juice 0.500000 1.000 1.0001E6329 12002621 12 Peach, juice - babyfood 0.500000 1.000 1.0001E6329 95002750 O Peppermint 3.000000 1.000 1.000 95002760 O Peppermint, oil 3.000000 1.000 1.000 12002850 1 2 Plum 0.500000 1.000 1.0001E6329 12002851 12 Plum - babyfood 0.500000 1.000 1.0001E6329 12002860 12 Plum, prune, fresh 0.500000 1.000 1.0001E6329 12002861 12 Plum, prune, fr esh - babyfood 0.500000 1.000 1.0001E6329 12002870 12 Plum, prune, dried 1.500000 1.000 1.0001E6329 12002871 12 Plum, prune, dried - babyfood 1.500000 1.000 1.0001E6329 12002880 12 Plum, prune, juice 0.500000 1.400 1.0001E6329 12002881 12 Plum, prune, juice - babyfood 0.500000 1.400 1.0001E6329 25002900 M Pork, meat 0.200000 1.000 1.0001F2439 25002901 M Pork, meat - babyfood 0.200000 1.000 1.0001F2439 25002910 M Pork, skin 0.200000 1.000 1.0001F2439 25002920 M Pork, meat byproducts 0.200000 1.000 1.0001F2439 25002921 M Pork, meat byproducts - babyfood 0.200000 1.000 1.0001F2439 2500293 0 M Pork, fat 0.200000 1.000 1.0001F2439 25002931 M Pork, fat - babyfood 0.200000 1.000 1.0001F2439 25002940 M Pork, kidney 0.200000 1.000 1.0001F2439 25002950 M Pork, liver 0.200000 1.000 1.0001F2439

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 9 of 14 60003010 P Poultry, other, meat 0.200000 1.000 1.0001F2439 60003020 P Poultry, other, liver 0.200000 1.000 1.0001F2439 60003030 P Poultry, other, meat byproducts 0.200000 1.000 1.0001F2439 60003040 P Poultry, other, fat 0.200000 1.000 1.0001F2439 60003050 P Poultry, other, skin 0.200000 1.000 1.0001F2439 29003120 M Rabbit, meat 1.000000 1.00 0 1.0001F2439 20003190 20 Rapeseed, oil 3.000000 1.000 1.0001E6291 20003191 20 Rapeseed, oil - babyfood 3.000000 1.000 1.0001E6291 26003390 M Sheep, meat 1.000000 1.000 1.0001F2439 2600 3391 M Sheep, meat - babyfood 1.000000 1.000 1.0001F2439 26003400 M Sheep, meat byproducts 36.000000 1.000 1.0001F2439 26003410 M Sheep, fat 1.000000 1.000 1.0001F2439 26003411 M Sheep, fa t - babyfood 1.000000 1.000 1.0001F2439 26003420 M Sheep, kidney 36.000000 1.000 1.0001F2439 26003430 M Sheep, liver 3.000000 1.000 1.0001F2439 95003520 O Spearmint 3.000000 1.000 1.000 95003530 O Spearmint, oil 3.000000 1.000 1.000 04013550 4A Spinach 5.000000 1.000 1.0001E6320 04013551 4A Spinach - babyfood 5.000000 1.000 1.0001 E6320 95003590 O Strawberry 4.000000 1.000 1.0008E7481 95003591 O Strawberry - babyfood 4.000000 1.000 1.0008E7481 95003600 O Strawberry, juice 4.000000 1.000 1.0008E7481 95003601 O Strawberry, juice - babyfood 4.000000 1.000 1.0008E7481 04023670 4B Swiss chard 3.000000 1.000 1.0008E7481 15003810 15 Triticale, flour 3.000000 1.000 1.0004F3054 50003820 P Turkey, meat 0.200000 1.000 1.0001F2439 50003821 P Turkey, meat - babyfood 0.200000 1.000 1.0001F2439 50003830 P Turkey, liver 0.200000 1.000 1.0001F2439 50003831 P Turkey, liver - babyfood 0. 200000 1.000 1.0001F2439 50003840 P Turkey, meat byproducts 0.200000 1.000 1.0001F2439 50003841 P Turkey, meat byproducts - babyfood 0.200000 1.000 1.0001F2439 50003850 P Turkey, fat 0.200000 1.000 1.0 001F2439 50003851 P Turkey, fat - babyfood 0.200000 1.000 1.0001F2439 50003860 P Turkey, skin 0.200000 1.000 1.0001F2439 50003861 P Turkey, skin - babyfood 0.200000 1.000 1.0001F2439 01013880 1 AB Turnip, roots 1.000000 1.000 1.0001E6335 05023890 5B Turnip, greens 4.000000 1.000 1.0001E6335 86010000 O Water, direct, all sources 0.045000 1.000 1.000FIRST

Full comment: FIRST Acute Non - crop Use 86020000 O Water, indirect, all sources 0.045000 1.000 1.000FIRST

Full comment: FIRST Acute Non - crop Use 15004010 15 Wheat, grain 3.000000 1.000 1.0004F3054 15004011 15 Wheat, grain - ba byfood 3.000000 1.000 1.0004F3054 15004020 15 Wheat, flour 3.000000 1.000 1.0004F3054 15004021 15 Wheat, flour - babyfood 3.000000 1.000 1.0004F3054 15004030 15 Wheat, germ 12.000000 1.000 1.0004F3054 15004040 15 Wheat, bran 12.000000 1.000 1.0004F3054

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 10 of 14 

## Attachment 2. Inputs for the chronic dietary exposure assessment of clopyralid. U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for CLOPYRALID 1994 - 98 data Residue file: C: \ Documents and Settings \ mdoherty \ My Documents \ Chemistry Reviews \ Clopyralid \ 2009 \ 117403 - 2009 Chronic.R98 Adjust. #2 NOT used Analysis Date 09 - 22 - 2009 Residue file dated: 09 - 22 - 2009/09:32:21/8 Reference dose (RfD) = 0.15 mg/kg bw/day

-------------------------------------------------------------------------------- Food Crop Residue Adj.Factors Comment EPA Code Grp Food Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 12000120 12 Apricot 0.500000 1.000 1.000 1E6239 12000121 12 Apricot - babyfood 0.500000 1.000 1.000 1E6239 12000130 12 Apricot, dried 0.500000 6.000 1.000 1E6239 12000140 12 Apricot, juice 0.500000 1.000 1.000 1E6239 12000141 12 Apricot, juice - babyfood 0.500000 1.000 1.000 1E6239 95000190 O Asparagus 1.000000 1.000 1.000 1E3979 15000250 15 Barley, pearled barley 3.000000 1.000 1.000 4F3054 15000251 15 Barley, pearled barley - babyfood 3.000000 1.000 1.000 4F3054 15000260 15 Barley, flour 3.000000 1.000 1.000 4F3054 15000261 15 Barley, flour - babyfood 3.000000 1.000 1.000 4F3054 15000270 15 Barley, bran 12.000000 1.000 1.000 4F3054 21000440 M Beef, meat 1.000000 1.000 1.000 1F2439 21000441 M Beef, meat - babyfood 1.000000 1.000 1.000 1F2439 21000450 M Beef, meat, dried 1.000000 1.920 1.000 1F2439 21000460 M Beef, meat byproducts 36.000000 1.000 1.000 1F2439 21000461 M Beef, meat byproducts - babyfood 36.000000 1.000 1.000 1F2439 21000470 M Beef, fat 1.000000 1.000 1.000 1F2439 21000471 M Beef,fat - babyfood 1.000000 1.000 1.000 1F2439 21000480 M Beef, kidney 36.000000 1.000 1.000 1F2439 21000490 M Beef, liver 3.000000 1.000 1.000 1F2439 21000491 M Beef, liver - babyf ood 3.000000 1.000 1.000 1F2439 01010500 1AB Beet, garden, roots 4.000000 1.000 1.000 1E6333 01010501 1AB Beet, garden, roots - babyfood 4.000000 1.000 1.000 1E6333 02000510 2 Beet, garden, t ops 3.000000 1.000 1.000 1E6333 01010520 1A Beet, sugar 2.000000 0.100 1.000 8F3600 01010521 1A Beet, sugar - babyfood 2.000000 0.100 1.000 8F3600 01010530 1A Beet, sugar, molasses 10.000000 1.000 1.000 8F3600 01010531 1A Beet, sugar, molasses - babyfood 10.000000 1.000 1.000 8F3600 13020570 13B Blueberry 0.500000 1.000 1.000 8E7481 13020571 13B Blueberry - b abyfood 0.500000 1.000 1.000 8E7481 05010610 5A Broccoli 2.000000 1.000 1.000 1E3999 05010611 5A Broccoli - babyfood 2.000000 1.000 1.000 1E3999 05010620 5A Broccoli, Chinese 2.000000 1.000 1.000 1E3999 05010640 5A Brussels sprouts 2.000000 1.000 1.000 1E3999 05010690 5A Cabbage 2.000000 1.000 1.000 1E3999 05010710 5A Cabbage , Chinese, napa 2.000000 1.000 1.000 1E3999 05010720 5A Cabbage, Chinese, mustard 2.000000 1.000 1.000 1E3999 05010830 5A Cauliflower 2.000000 1.000 1.000 1E3999 12000900 12 Cherr y 0.500000 1.000 1.000 1E6329 12000901 12 Cherry - babyfood 0.500000 1.000 1.000 1E6329 12000910 12 Cherry, juice 0.500000 1.500 1.000 1E6329 12000911 12 Che rry, juice - babyfood 0.500000 1.500 1.000 1E6329 40000930 P Chicken, meat 0.200000 1.000 1.000 4F3054 40000931 P Chicken, meat - babyfood 0.200000 1.000 1.000 4F3054 40000940 P C hicken, liver 0.200000 1.000 1.000 4F3054 40000950 P Chicken, meat byproducts 0.200000 1.000 1.000 4F3054 40000951 P Chicken, meat byproducts - babyfoo 0.200000 1.000 1.000 4F3054 40000960 P Chicken, fat 0.200000 1.000 1.000 4F3054 40000961 P Chicken, fat - babyfood 0.200000 1.000 1.000 4F3054 40000970 P Chicken, skin 0.200000 1.000 1.000 4F3054 40000971 P Chicken, skin - babyfood 0.200000 1.000 1.000 4F3054 15001200 15 Corn, field, flour 1.000000 1.000 1.000 4F4379 15001201 15 Corn, field, flour - babyfood 1.000000 1.000 1.000 4F4379 15001210 15 Corn, field, meal 1.000000 1.000 1.000 4F4379 15001220 15 Corn, field, bran 1.000000 1.000 1.000 4F4379

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 11 of 14 15001230 15 Corn, field, starch 1.000000 1.000 1.000 4F4379 1500123 1 15 Corn, field, starch - babyfood 1.000000 1.000 1.000 4F4379 15001240 15 Corn, field, syrup 1.000000 1.500 1.000 4F4379 15001241 15 Corn, field, syrup - babyfood 1.000000 1.500 1.000 4F4379 15001 250 15 Corn, field, oil 1.000000 1.000 1.000 4F4379 15001251 15 Corn, field, oil - babyfood 1.000000 1.000 1.000 4F4379 15001260 15 Corn, pop 1.000000 1.000 1.000 4F4379 150 01270 15 Corn, sweet 1.000000 1.000 1.000 4F4379 15001271 15 Corn, sweet - babyfood 1.000000 1.000 1.000 4F4379 95001300 O Cranberry 4.000000 1.000 1.000 1E6340 9 5001301 O Cranberry - babyfood 4.000000 1.000 1.000 1E6340 95001310 O Cranberry, dried 4.000000 4.000 1.000 1E6340 Conc. factor from cherry 95001320 O Cranberry, juice 4.000000 1.100 1.000 1E6340 95001321 O Cranberry, juice - babyfood 4.000000 1.100 1.000 1E6340 13021360 13B Currant 0.500000 1.000 1.000 8E7481 70001450 P Egg, whole 0.100000 1.000 1.000 4F3054 70001451 P Egg, whole - babyfood 0.100000 1.000 1.000 4F3054 70001460 P Egg, white 0.100000 1.000 1.000 4F3054 70001461 P Egg, white (solids) - babyfood 0.10000 0 1.000 1.000 4F3054 70001470 P Egg, yolk 0.100000 1.000 1.000 4F3054 70001471 P Egg, yolk - babyfood 0.100000 1.000 1.000 4F3054 13021490 13B Elderberry 0.500 000 1.000 1.000 8E7481 20001630 20 Flaxseed, oil 3.000000 1.000 1.000 1E6227 23001690 M Goat, meat 1.000000 1.000 1.000 1F2439 23001700 M Goat, meat byproducts 36.0 00000 1.000 1.000 1F2439 23001710 M Goat, fat 1.000000 1.000 1.000 1F2439 23001720 M Goat, kidney 36.000000 1.000 1.000 1F2439 23001730 M Goat, liver 3 .000000 1.000 1.000 1F2439 13021740 13B Gooseberry 0.500000 1.000 1.000 8E7481 95001880 O Hop 5.000000 1.000 1.000 1E6283 24001890 M Horse, meat 1.000000 1.000 1.000 1F2439 13021910 13B Huckleberry 0.500000 1.000 1.000 8E7481 05011960 5A Kohlrabi 2.000000 1.000 1.000 1E3999 28002210 M Meat, game 1.000000 1.000 1.000 1F2439 27002220 D Milk, fat 0.200000 1.000 1.000 1F2439 27002221 D Milk, fat - baby food/infant for 0.200000 1.000 1.000 1F2439 27012230 D Milk, nonfat solids 0.200000 1.000 1.000 1F2439 27012231 D Milk, nonfat solids - baby food/in 0.200000 1.000 1.000 1F2439 27022240 D Milk, water 0.200000 1.000 1.000 1F2439 27022241 D Milk, water - babyfood/infant form 0.200000 1.000 1.000 1F2439 27032251 D Milk, sugar (lactose) - baby food/ 0.200000 1.000 1.000 1F2439 05022290 5B Mustard greens 5.000000 1.000 1.000 1E6334 12002300 12 Nectarine 0.500000 1.000 1.000 1E6329 15002310 15 Oat, bran 3.000000 1.000 1.000 4F3054 15002320 15 Oat, flour 3.000000 1.000 1.000 4F3054 15002321 15 Oat, flour - babyfood 3.000000 1.000 1.000 4F3054 15002330 15 Oat, groats/rolled oats 3.000000 1.000 1.000 4F3054 15002331 15 Oat, groats/rolled oats - babyfood 3.000000 1.000 1.000 4F3054 12002600 12 Peach 0.500000 1.000 1.000 1E6329 12002601 12 Peach - babyfood 0.500000 1.000 1.000 1E6329 12002610 12 Peach, dried 0.500000 7.000 1.000 1E6329 12002611 12 Peach, dried - babyfoo d 0.500000 1.000 1.000 1E6329 12002620 12 Peach, juice 0.500000 1.000 1.000 1E6329 12002621 12 Peach, juice - babyfood 0.500000 1.000 1.000 1E6329 95002750 O Peppermint 3.000000 1.000 1.000 95002760 O Peppermint, oil 3.000000 1.000 1.000 12002850 12 Plum 0.500000 1.000 1.000 1E6329 12002851 12 Plum - babyfood 0.500000 1.000 1.000 1E6329 12002860 12 Plum, prune, fresh 0.500000 1.000 1.000 1E6329 12002861 12 Plum, prune, fresh - babyfood 0.500000 1.000 1.000 1E6329 12002870 12 Plum, prune, dried 1.500000 1.000 1.000 1E6329 12002871 12 Plum, prune, dried - babyfood 1.500000 1.000 1.000 1E6329 12002880 12 Plum, prune, juice 0.500000 1.400 1.000 1E6329 12002881 12 Plum, prune, juice - babyf ood 0.500000 1.400 1.000 1E6329 25002900 M Pork, meat 0.200000 1.000 1.000 1F2439 25002901 M Pork, meat - babyfood 0.200000 1.000 1.000 1F2439 25002910 M Pork, skin 0.200000 1.000 1.000 1F2439 25002920 M Pork, meat byproducts 0.200000 1.000 1.000 1F2439 25002921 M Pork, meat byproducts - babyfood 0.200000 1.000 1.000 1F2439 25002930 M Pork, fat 0.200000 1.000 1.000 1F2439

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 12 of 14 25002931 M Pork, fat - babyfood 0.200000 1.000 1.000 1F2439 25002940 M Pork, kidney 0.200000 1.000 1.000 1F2439 25002950 M Pork, liver 0.200000 1.000 1.000 1F2439 60003010 P Poultry, other, meat 0.200000 1.000 1.000 1F2439 60003020 P Poultry, other, liver 0.200000 1.000 1.000 1F2439 60003030 P Poultry, other, meat byproducts 0.200000 1.000 1.000 1F2439 60003040 P Poultry, other, fat 0.200000 1.000 1.000 1F2439 60003050 P Poultry, other, skin 0.200000 1.000 1.000 1F2439 29003120 M Rabbit, meat 1.000000 1.000 1.000 1F2439 20003190 20 Rapeseed, oil 3.000000 1.000 1.000 1E6291 20003191 20 Rapeseed, oil - babyfood 3.000000 1.000 1.000 1E6291 26003390 M Sheep, meat 1.000000 1.000 1.000 1F2439 26003391 M Sheep, meat - babyfood 1.000000 1.000 1.000 1F2439 26003400 M Sheep, meat byproducts 36.000000 1.000 1.000 1F2439 26003410 M Sheep, fat 1.000000 1.000 1.000 1F2439 26003411 M Sheep, fat - babyfood 1.000000 1.000 1.000 1F2439 26003420 M Sheep, kidney 36.000000 1.000 1.000 1F2439 26003430 M Sheep, l iver 3.000000 1.000 1.000 1F2439 95003520 O Spearmint 3.000000 1.000 1.000 95003530 O Spearmint, oil 3.000000 1.000 1.000 04013550 4A Spinach 5.000000 1.000 1.000 1E6320 04013551 4A Spinach - babyfood 5.000000 1.000 1.000 1E6320 95003590 O Strawberry 4.000000 1.000 1.000 8E7481 95003591 O Strawberry - babyf ood 4.000000 1.000 1.000 8E7481 95003600 O Strawberry, juice 4.000000 1.000 1.000 8E7481 95003601 O Strawberry, juice - babyfood 4.000000 1.000 1.000 8E7481 04023670 4B Swiss chard 3.000000 1.000 1.000 8E7481 15003810 15 Triticale, flour 3.000000 1.000 1.000 4F3054 50003820 P Turkey, meat 0.200000 1.000 1.000 1F2439 50003821 P Turkey, meat - babyfood 0.200000 1.000 1.000 1F2439 50003830 P Turkey, liver 0.200000 1.000 1.000 1F2439 50003831 P Turkey, liver - babyfood 0.200000 1.000 1.000 1F2439 50003840 P Turkey, me at byproducts 0.200000 1.000 1.000 1F2439 50003841 P Turkey, meat byproducts - babyfood 0.200000 1.000 1.000 1F2439 50003850 P Turkey, fat 0.200000 1.000 1.000 1F2439 50003851 P Turkey, fat - babyfood 0.200000 1.000 1.000 1F2439 50003860 P Turkey, skin 0.200000 1.000 1.000 1F2439 50003861 P Turkey, skin - babyfood 0.200000 1.000 1.000 1F2439 01013880 1AB Turnip , roots 1.000000 1.000 1.000 1E6335 05023890 5B Turnip, greens 4.000000 1.000 1.000 1E6335 86010000 O Water, direct, all sources 0.011900 1.000 1.000 FIRST Chronic Non crop Us e 86020000 O Water, indirect, all sources 0.011900 1.000 1.000 FIRST Chronic Non crop Use 15004010 15 Wheat, grain 3.000000 1.000 1.000 4F3054 15004011 15 Wheat, grain - babyfood 3.000000 1. 000 1.000 4F3054 15004020 15 Wheat, flour 3.000000 1.000 1.000 4F3054 15004021 15 Wheat, flour - babyfood 3.000000 1.000 1.000 4F3054 15004030 15 Wheat, germ 12.000000 1.000 1.000 4F3054 15004040 15 Wheat, bran 12.000000 1.000 1.000 4F3054

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 13 of 14 

## Attachment 3. Summary of the acute dietary exposure and risk estimates for clopy ralid. U.S. Environmental Protection Agency Ver. 2.02 DEEM - FCID ACUTE Analysis for CLOPYRALID (1994 - 98 data) Residue file: 117403 - 2009 Acute.R98 Adjustment factor #2 NOT used. Analysis Date: 09 - 22 - 2009/09:35:18 Residue file dated: 09 - 22 - 2009/ 09:31:12/8 NOEL (Acute) = 75.000000 mg/kg body - wt/day Daily totals for food and foodform consumption used. Run Comment: ""

=============================================================================== Summary calculations (per capita): 95th Perc entile 99th Percentile 99.9th Percentile Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- U.S. Population: 0.03 5084 4.68 2137 0.056291 7.51 1332 0.099454 13.26 754 All infants: 0.043768 5.84 1713 0.068045 9.07 1102 0.118739 15.83 631 Children 1 - 2 yrs: 0.070616 9.42 1062 0.099413 13.26 754 0.2 41641 32.22 310 Children 3 - 5 yrs: 0.060428 8.06 1241 0.086358 11.51 868 0.157416 20.99 476 Children 6 - 12 yrs: 0.042390 5.65 1769 0.057115 7.62 1313 0.098244 13.10 763 Youth 13 - 19 yrs: 0.0258 42 3.45 2902 0.043040 5.74 1742 0.083194 11.09 901 Adults 20 - 49 yrs: 0.022783 3.04 3291 0.034900 4.65 2148 0.057647 7.69 1301 Adults 50+ yrs: 0.019576 2.61 3831 0.030007 4.00 2499 0. 049151 6.55 1525 Females 13 - 49 yrs: 0.021362 2.85 3510 0.031090 4.15 2412 0.050494 6.73 1485

### Clopyralid (117401/117403) Dietary Exposure and Risk Assessment DP Number: 368855

Page 14 of 14 

## Attachment 4. Summary of the chronic dietary exposure and risk estimates for clop yralid. U.S. Environmental Protection Agenc y Ver. 2.00 DEEM - FCID Chronic analysis for CLOPYRALID (1994 - 98 data) Residue file name: C: \ Documents and Settings \ mdoherty \ My Documents \ Chemistry Reviews \ Clopyralid \ 2009 \ 117403 - 2009 Chronic.R98 Adjustment factor #2 NOT used. Analysis Date 09 - 22 - 2009/09:33:15 Residue file dated: 09 - 22 - 2009/09:32:21/8 Reference dose (RfD, Chronic) = .15 mg/kg bw/day

======================================================= ======================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- --------- ---- --------------- U.S. Population (total) 0.013212 8.8% U.S. Population (spring season) 0.013517 9.0% U.S. Population (summer season) 0.013180 8.8% U.S. P opulation (autumn season) 0.013053 8.7% U.S. Population (winter season) 0.013107 8.7% Northeast region 0.013495 9.0% Midwest region 0.013920 9.3% Southern region 0.012456 8.3% Western region 0.013400 8.9% Hispanics 0.013458 9.0 % Non - hispanic whites 0.013086 8.7% Non - hispanic blacks 0.013803 9.2% Non - hisp/non - white/non - black 0.013005 8.7% All infants (< 1 year) 0.012778 8.5% Nursing infants 0.005326 3.6% Non - nursing infants 0.015607 10.4% Children 1 - 6 yrs 0.032165 21.4% Children 7 - 12 yrs 0.020267 13.5% Females 13 - 19 (not preg or nursing) 0.011014 7.3% Females 20+ (not preg or nursing) 0.009012 6.0% Females 13 - 50 yrs 0.010319 6.9% Females 13+ (preg/not nursing) 0.011001 7.3% Females 13+ (nursing) 0.012041 8.0% Males 13 - 19 yrs 0.014231 9.5% Males 20+ yrs 0.010759 7.2% Seniors 55+ 0.008885 5.9% Children 1 - 2 yrs 0.035056 23.4% Children 3 - 5 yrs 0.031908 21.3% Children 6 - 12 yrs 0.021317 14.2% Youth 13 - 19 yrs 0.012669 8.4% Adults 20 - 49 yrs 0.010403 6.9% Adults 50+ yrs 0.008967 6.0% Females 13 - 49 yrs 0.009685 6.5%

----------------------------------------------------------- --------------------