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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF 

PREVENTION, PESTICIDES AND 

TOXIC SUBSTANCES 

MEMORANDUM

DATE: January 7, 2009

SUBJECT: Transmittal memo of materials for the FIFRA Scientific Advisory Panel meeting on “Draft 

Framework and Case Studies on Atrazine, Human Incidents, and the Agricultural Health Study: 

Incorporation of Epidemiology and Human Incident Data into Human Health Risk Assessment” 

to be held February 2-5, 2010

FROM: Tina E. Levine, Ph.D. 

Director

Health Effects Division (7509P)

TO: Myrta Christian

Designated Federal Official

FIFRA Scientific Advisory Panel

Office of Science Coordination and Policy (7201M)

On February 2-5, 2010, EPA will present its draft framework for incorporating epidemiology and human 

incident data into human health risk assessment along with three draft case studies to the FIFRA SAP. The 

purpose of this SAP meeting is to consider broad science issues associated with incorporating epidemiology and 

human incident data into human health risk assessment. In addition, the February meeting is also one of three 

SAPs being held in 2010 on science issues related to human health effects of atrazine. This memorandum 

transmits the Agency’s materials listed below for the February, 2010 meeting. 

This transmission includes the draft framework paper and draft case study on ecologic and retrospective 

epidemiologic study designs (Case study 1). An overview of the draft case study on using data from a prospective 

study, the Agricultural Health Study, (Case study 2) is provided in this transmission. The draft framework, Case 

study 1, and the overview of Case study 2 are included together in a single file (Epi-Incident 

Framework_Draft.doc). An addendum containing more details on Case study 2, Case study 3 on using human 

incident data, and the charge questions for the Panel will be provided in separate transmissions to the SAP.
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Document Transmitted to SAP File Name

Indicate 

Whether 

FIFRA 

10(g) or © 

Protected

DRAFT Framework for Incorporating

Human Epidemiologic & Incident Data in

Health Risk Assessment, January 7, 2010 (Document 

includes Case study A and overview of Case study B)

Epi-Incident Framework_Draft.doc

No

Mattix KD, Winchester PD, and Scherer LR. 2007. 

Incidence of abdominal wall defects is related to surface 

water atrazine and nitrate levels. Journal of Pediatric 

Surgery; 42, 947-949.

©

No

Ochoa- Acuña H, Carbajo C. 2009. Risk of limb birth 

defects and mother’s home proximity to cornfields. 

Science of the Total Environment, 407: 4447-4451.

©

No

Ochoa-Acuña H, Frankenberger J, Hahn L, and Carbajo 

C. 2009. Drinking water herbicide exposure in Indiana 

and prevalence of small-for-gestational-age and preterm

delivery. Environmental Health Perspectives, 117(10): 

1619-1624.

©

No

Villanueva C, Durand G, Coutte M, Chevrier C, and 

Cordier S. 2005. Atrazine in municipal drinking water 

and risk of low birth weight, preterm delivery, and smallfor-gestational-age Status. Environmental Health 

Perspectives, 62(6): 400-405.

©

No

Winchester PD, Huskins J, and Ting J. 2009. 

Agrichemicals in surface water and birth defects in the 

United States. Acta Paediatrica, 98(4): 664-669.

©

No

Bakke, B., A.J. De Roos, D.B. Barr, P.A. Steward, A. 

Blair, L. Beane-Freeman, C.F. Lynch, R.H. Allen, M.C.R. 

Alavanja, and R. Vemeulen. 2008. Exposure to atrazine 

and selected non-persistent pesticides among corn farmers 

during a growing season. Journal of Exposure Science 

and Environmental Epidemiology, 2008: 1-11.

©

No

Thomas K.W., Dosemeci M., Hoppin J.A., Sheldon L.S., 

Croghan C.W., Gordon S.M., Jones M.L., Reynolds S.J., 

Raymer J.H., Akland G.G., Lynch C.F., Knott C.E., 

Sandler D.P., Blair A.E., and Alavanja M.C.. Urinary 

biomarker, dermal, and air measurement results for 2,4-D 

and chlorpyrifos farm applicators in the Agricultural 

Health Study. J Expos Sci Environ Epidemiol 2009: 

epub ahead of print, 25 February doi: 10.1038/jes.2009.6.

©

No

US EPA. 2007. Review of Worker Exposure Assessment 

Methods. FlFRA Scientific Advisory Panel.

ExposureSAP.Jan2007.V121206.pdf No