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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND

 POLLUTION PREVENTION

MEMORANDUM

Date: December 5, 2013 

SUBJECT: Fenamidone – Acute and Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessments to Support New Uses on Ginseng, Succulent 

Beans, Bulb Onion (Subgroup 3-07A), and Green Onion (Subgroup 3-07B).

PC Code: 046679 DP Barcode: D416496 

Decision No.: 475185 Registration No.:

Petition No.: 3E8150 Regulatory Action: Section 3 Registration

Risk Assessment Type: Dietary Risk Assessment CAS No.: 161326-34-7

FROM: Karen Milians, Ph.D., Chemist

Risk Assessment Branch 7

Health Effects Division (7508P)

THROUGH: Dennis McNeilly, Chemist

Meheret Negussie, Chemist

Ideliz Negron-Encarnacion, Ph.D., Chemist 

Dietary Exposure Science Advisory Council (DESAC)

TO: Laura Nollen, Risk Manager Reviewer

Barbara Madden, Risk Manager

Registration Division (7505P)

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments 

were conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food 

consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health and 

Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA).The analyses 

were performed to support the Section 3 request for use on ginseng, succulent beans bulb onion 

(Subgroup 3-07A), and green onion (Subgroup 3-07B). 

Acute Dietary Exposure Assessment
Fenamidone Dietary Exposure and Risk Assessment DP Number: D416496

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A slightly unrefined acute dietary risk assessment was conducted which used maximum field 

trial residue values, assumed 100 percent crop treated (% CT) for all commodities, incorporated 

DEEMTM default processing factors and empirical factors were used for processed commodities 

and included modeled drinking water estimates. The estimated exposure (food and water) to the 

U.S. population from the existing and proposed new uses of fenamidone resulted in an estimated 

risk equivalent to 3% of the acute population adjusted dose (aPAD) at the 95th percentile. The 

most highly exposed subpopulation was children 1 - 2 years with an estimated exposure 

equivalent to 5% of the aPAD at the 95th percentile.

Chronic Dietary Exposure Assessment

A chronic dietary risk assessment was conducted which used maximum field trial residue values, 

assumed 100 % CT for all commodities, incorporated DEEMTM default processing factors for 

many processed commodities and included modeled drinking water estimates. The estimated 

exposure (food and water) to the U.S. population from the existing and proposed new uses of 

fenamidone resulted in an estimated risk equivalent to 53% of the chronic population adjusted 

dose (cPAD). The most highly exposed subpopulation was children 1 – 2 years with an 

estimated exposure equivalent to 89% of the cPAD.

Cancer Dietary Exposure Assessment

Fenamidone is not likely to be a human carcinogen; therefore a cancer dietary risk assessment is 

not required for this chemical. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point 

of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References which discuss the acute and chronic risk assessments in more detail 

are available on the EPA/pesticides web site: “Available Information on Assessing Exposure 

from Pesticides In Food, A User’s Guide,” 5-NOV-2013, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (29-OCT2013).

The most recent dietary risk assessment for fenamidone was conducted by Alexandra LaMay

(D391040, 07/7/11).

II. Residue Information
Fenamidone Dietary Exposure and Risk Assessment DP Number: D416496

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Tolerances are currently established for residues of fenamidone under 40 CFR 180.579 (a)(1) 

for a variety of primary crops including bulb vegetables, cucurbit vegetables, tuberous and corm 

vegetables, brassica vegetables, leafy vegetables, fruiting vegetables, cotton, non bell pepper, 

sunflower, and tomato ranging from 0.02 ppm to 60 ppm. Livestock commodity tolerances are 

established for residues of fenamidone and RPA 717879 (DADK-Fen) in milk, fat, meat and 

meat byproducts under 180.579(a)(2). Rotational crop tolerances are established for residues of 

fenamidone and RPA 717870 (DADK-Fen) in wheat, corn and soybean commodities and 

strawberries ranging from 0.02 ppm to 0.50 ppm under 40CFR 180.579(d).

The residues of concern for tolerance setting and risk assessment purposes are summarized in the 

table below.

Table 1: Residues of Concern in Primary Crops, Livestock, Rotational Crops, and Water

Matrix Tolerance Expression Residues for Risk Assessment

Registered/proposed primary crops 

excluding root vegetables fenamidone fenamidone, RPA 717879 (DADK-Fen), RPA 408056 (DA-Fen), RPA 405862

Carrot1fenamidone fenamidone, RPA 413255

Animal commodities fenamidone, RPA 717879 

(DADK-Fen)

fenamidone, RPA 717879 (DADK-Fen), RPA 408056 

(DA-Fen)

Rotational Crops fenamidone, RPA 717879 

(DADK-Fen)

fenamidone, RPA 717879 (DADK-Fen), and RPA 

408056 (DA-Fen) (free and conjugated)

Water NA Fenamidone, RPA 412636, RPA 412708, RPA 411639, 

RPA 413255, RPA 409446, and RPA 410995

1

For future field trials with the root vegetables, HED recommends that parent fenamidone, and the metabolites RPA

413255, RPA 717879 (DADK-Fen) and RPA 408056 (DA-Fen), and RPA 405862 are measured.

The tolerances are presented in the most recent residue chemistry document (K. Milians, 

D409835).

The new residues were included in the acute and chronic dietary risk assessment and a 

description of how they were calculated are shown in Table 2. 

Table 2. Summary of New Residue Values Added to the Acute and Chronic Dietary Risk Assessment

Crop/Commodity*

Residue Value 

(ppm) Comment

Ginseng 1.19

The field rotational crop studies monitored for residues of 

fenamidone and metabolites (RPA 717879, RPA 408056 

and RPA 405862) in ginseng. RPA 413255 is included as a 

residue of concern for ginseng since it is in the same crop 

group as carrot, however, this analyte was not determined in 

the field trials for ginseng. Data from carrot was used to 

estimate a factor to account for RPA 413255. The carrot 

metabolism study (469291101.der.doc) indicated that 

residues of RPA 413255 were 0.6x that of fenamidone

(D314318, T. Bloem, 7-Jun-2007). The ginseng field trials 

showed that residues of parent fenamidone were 0.35 ppm, 

conjugated RPA 408056 were 0.024 ppm, RPA 717879 

were <0.02 and RPA 405862 were 0.022 for combined 

residues of 0.98 ppm (D409835, K. Milians). Using the 

0.6x factor to account for RPA 413255 the combined residue 

level would be 1.19 ppm (0.98 ppm + 0.35 ppm x 0.21ppm).
Fenamidone Dietary Exposure and Risk Assessment DP Number: D416496

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Table 2. Summary of New Residue Values Added to the Acute and Chronic Dietary Risk Assessment

Crop/Commodity*

Residue Value 

(ppm) Comment

Snap Beans 0.52

The field crop studies monitored for residues of fenamidone 

and metabolites (RPA 717879, RPA 408056 and RPA 

405862) in snap beans. Residues of fenamidone, RPA 

405862, RPA 717879, RPA 408056 in snap beans were 

0.46, 0.02, 0.02 and 0.02 ppm, respectively, for a total 

residue of 0.52 ppm (MRID 49052103; D409835, K. 

Milians).

Onion, bulb, subgroup 3-

07A 0.186

Adequate data were previously submitted to establish 

tolerances on these subgroups based on residue data for bulb 

onions. A. LaMay (D391040, 07/7/11)

Onion, bulb, subgroup 3-

07B

1.23

Adequate data were previously submitted to establish 

tolerances on this subgroup based on residue data for green 

onions. A. LaMay (D391040, 07/7/11)

DEEM (ver. 7.81) default processing factors were maintained for all commodities excluding 

grape juice, dried potato, tomato paste, tomato puree, field corn processed commodities and 

soybean processed commodities. For these commodities, the DEEM (ver. 7.81) default 

processing factors were reduced to 1 based on processing data (grape), were reduced to 1 based 

on the application of empirical processing factors to the RAC residue (tomato paste, tomato 

puree, and dried potato; D277818, T. Bloem, 4/22/04), or were reduced to 1 based on lack of 

residues at exaggerated rates in the RAC (field corn processed commodities and soybean 

processed commodities; D357372, A. LaMay, 2/24/09).

III. Percent Crop Treated Information

For all commodities 100 percent crop treated was assumed. 

IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED, J. K. Wolf, D409837, 09/18/13) and were 

incorporated directly into the acute and chronic dietary assessments. Water residues were 

incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and “water, 

indirect, all sources.”

Monitoring data are not available for residues of fenamidone and its metabolites in water; 

therefore EFED has provided modeled values for ground and surface water. The modeled 

EDWCs (estimated drinking water concentrations) are reported for parent and its degradation 

products, RPA-412636, RPA-412108, RPA-411639, RPA-413255, RPA-409446, and RPA410995. These are the residues of concern in drinking water, as determined by the Metabolite 

Assessment Committee (MARC, 05/25/04). Surface water EDWCs were calculated using a Tier 

II model for surface water PRZM (Pesticide Root Zone Model, Version 3.122) and EXAMS 

(Version 2.98.04) using the PE5 platform. The EDWC in ground water were estimated using the 

Screening Concentration In Ground Water model (SCI-GROW, Version 2.3) and PRZM-GW 

(Pesticide Root Zone Model for Groundwater, version 1.0, August 31, 2012). EDWCs in surface 

source water were corrected using the default percent crop area factor (0.91). The default PCA 
Fenamidone Dietary Exposure and Risk Assessment DP Number: D416496

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was applied because fenamidone can be used on numerous crops. No water treatment effects 

were considered in this assessment. These models and their descriptions are available at the EPA 

internet site: http://www.epa.gov/oppefed1/models/water/.

The drinking water EDWCs recommended for use in the human health dietary risk assessment 

are those estimated for groundwater. The highest daily total fenamidone residue concentration in 

shallow groundwater estimated by PRZM-GW is 207μg/L and the average concentration after 

breakthrough was 139 μg/L for the Central Sands Region of Wisconsin from 30 years of 

continuous use. These estimates represent potential exposure to private drinking water well in a 

highly vulnerable pesticide use area where numerous pesticide residues have been detected in 

groundwater.

For both the acute and chronic dietary analysis, HED will use the maximum ground water 

EDWC of 207 μg/L (0.207 ppm), since it is the highest EDWC reported for fenamidone.

Table 3 Summary of Estimated Surface Water and Groundwater Concentrations 

for Fenamidone.

Scenario Surface Water Conc., ppb a Groundwater Conc., ppb b

Acute 41.7 207

Chronic (non-cancer) 11.9 207

Chronic (cancer) 5.99 207

a

From the Tier II PRZM-EXAMS - Index Reservoir model. Input parameters are based on ...

b

From the PRZM-GW model.

USEPA, 2013, J. K. Wolf, D409837.

V. DEEM-FCID Program and Consumption Information

Fenamidone acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99

years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 
Fenamidone Dietary Exposure and Risk Assessment DP Number: D416496

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The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.

VI. Toxicological Information

The HED Hazard Identification and Assessment Review Committee (HIARC) met on 18-March2003 to evaluate the toxicological database for fenamidone (TXR No. 0052379). At that meeting 

the lack of a developmental neurotoxicity study was indentified and a 10X database uncertainty

factor was applied. Subsequent to that finding, the registrant has addressed the data gap, and 

HED has determined that the database UF is no longer required. Based on toxicological 

considerations and the residue assumptions used in the dietary analyses, HED concludes that the 

FQPA Safety Factor can be reduced to 1x when assessing acute and chronic dietary exposures. 

Table 3 summarizes the points of departure used for dietary risk assessment. 

Table 3. Summary of Toxicological Doses and Endpoints for Fenamidone Dietary 

Exposure Assessment

Exposure

Scenario Point of Departure

Uncertainty/

FQPA SF

RfD and PAD Study and Toxicological Effects

Acute Dietary

(All populations)

NOAEL = 125 

mg/kg/day

UFA= 10x

UFH= 10x

FQPA SF= 1

Acute RfD = 1.25 

mg/kg/day

Acute PAD = 1.25 

mg/kg/day

Acute Neurotoxicity in Rats; LOAEL = 

500 mg/kg/day based on urination, 

staining/soiling of the anogenital region, 

mucous in the feces, and unsteady gait in 

the females

Chronic Dietary 

(All populations)

NOAEL= 2.83 

mg/kg/day

UFA= 10x

UFH= 10x

FQPA SF= 1

Chronic RfD = 

0.0283 mg/kg/day

Chronic PAD = 

0.0283 mg/kg/day

2 Year Chronic Toxicity/Carcinogenicity in 

Rats; LOAEL = 7.07/9.24 mg/kg/day 

(M/F) based on increase in severity of 

diffuse thyroid C-cell hyperplasia in both 

sexes

Cancer Based on the negative carcinogenic potential of fenamidone in rats and mice, the HIARC classified 

fenamidone as “not likely” to be a human carcinogen by all relevant routes of exposure.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark the beginning 

of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. 

LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from animal to human (intraspecies). UFH = 

potential variation in sensitivity among members of the human population (interspecies). FQPA SF = FQPA Safety Factor. PAD = population 

adjusted dose (a = acute, c = chronic). RfD = reference dose. 
Fenamidone Dietary Exposure and Risk Assessment DP Number: D416496

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VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in Table 4 are for the general 

U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50+ years.

The estimated exposure (food and water) to the U.S. population from the existing and proposed 

new uses of fenamidone resulted in an estimated risk equivalent to 3% of the aPAD at the 95th

percentile. The most highly exposed subpopulation was children 1 – 2 years with an estimated 

exposure equivalent to 5% of the aPAD at the 95th percentile.

The estimated exposure (food and water) to the U.S. population from the existing and proposed 

new uses of fenamidone resulted in an estimated risk equivalent to 53% of the cPAD. The most 

highly exposed subpopulation was children 1 – 2 years with an estimated exposure equivalent to 

89 % of the cPAD.

The results of the acute and chronic dietary exposure analysis are reported in the summary table 

below (Table 4). 

Fenamidone is not likely to be a human carcinogen; therefore a cancer dietary risk assessment is 

not required for this chemical. 

Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Fenamidone

Population 

Subgroup

Acute Dietary

(95th Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population 0.042858 3.4 0.014881 53

N/A N/A

All Infants (< 1 year old) 0.049122 3.9 0.019601 69

Female 13-50 years old 0.044191 3.5 0.014513 51

Children 1-2 years old 0.059469 4.8 0.025185 89

Children 3-5 years old 0.058441 4.7 0.022511 80

Children 6-12 years old 0.035464 2.8 0.014602 52

Youth 13-19 years old 0.030767 2.5 0.011064 39

Adults 20-49 years old 0.042344 3.4 0.014350 51

Adults 50+ years old 0.043906 3.5 0.014768 52
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Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Fenamidone

Population 

Subgroup

Acute Dietary

(95th Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

Females 13-49 years old 0.044264 3.5 0.014516 51

N/A is “not applicable”. Populations with highest exposure are shown in bold. 

* PAD = population adjusted dose.

VIII. Characterization of Inputs/Outputs

The acute and chronic dietary assessments are considered to be conservative, using field trial 

data conducted at maximum application rate and minimum PHI and assuming 100% CT for all 

commodities, as well as using default drying concentration factors and empirical factors. The

results of the acute and chronic dietary risk assessments are unlikely to underestimate risk. 

IX. Conclusions

Slightly refined acute and chronic dietary risk assessments were conducted which used 

maximum field trial residue values, assumed 100 % CT for all commodities and incorporated 

DEEMTM default processing factors as well as empirical factors were used for processed 

commodities. 

The estimated exposure (food and water) to the U.S. population from the existing and proposed 

new uses of fenamidone resulted in an estimated risk equivalent to 3.4% of the aPAD at the 95th

percentile. The most highly exposed subpopulation was children 1 – 2 years with an estimated 

exposure equivalent to 5% of the aPAD at the 95th percentile.

The estimated exposure (food and water) to the U.S. population from the existing and proposed 

new uses of fenamidone resulted in an estimated risk equivalent to 53% of the cPAD. The most 

highly exposed subpopulation was children 1 – 2 years with an estimated exposure equivalent to 

89% of the cPAD.

Acute and chronic dietary risks from the existing and newly proposed used of fenamidone are 

not of concern.

X. List of Attachments

Attachment 1. Chronic Dietary Risk Assessment Results file.

Attachment 2. Acute Dietary Risk Assessment Results file.

Attachment 3. Acute and Chronic Food plus Water Residue Input file.

Attachment 1. Fenamidone Chronic Dietary Risk Assessment Results File

US EPA Ver. 3.16, 03-08-d
Fenamidone Dietary Exposure and Risk Assessment DP Number: D416496

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DEEM-FCID Chronic analysis for FENAMIDONE NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\kmilians\Desktop\MODELS\DEEM\FENAMIDONE ACUTE 

AND CHRONIC F_W041311.R08

 Adjustment factor #2 NOT used.

Analysis Date 11-19-2013/12:08:00 Residue file dated: 11-19-2013/12:06:01

Reference dose (RfD, Chronic) = .0283 mg/kg bw/day

COMMENT 1: 100x uncertainity factor for acute and chronic; 1x FQPA safety factor for acute 

and chronic; EDWC

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.014881 52.6%

Hispanic 0.013448 47.5%

Non-Hisp-White 0.015116 53.4%

Non-Hisp-Black 0.013951 49.3%

Non-Hisp-Other 0.017714 62.6%

Nursing Infants 0.009144 32.3%

Non-Nursing Infants 0.024272 85.8%

Female 13+ PREG 0.013363 47.2%

Children 1-6 0.023021 81.3%

Children 7-12 0.013691 48.4%

Male 13-19 0.010802 38.2%

Female 13-19/NP 0.011339 40.1%

Male 20+ 0.013446 47.5%

Female 20+/NP 0.015545 54.9%

Seniors 55+ 0.014586 51.5%

All Infants 0.019601 69.3%

Female 13-50 0.014513 51.3%

Children 1-2 0.025185 89.0%

Children 3-5 0.022511 79.5%

Children 6-12 0.014602 51.6%

Youth 13-19 0.011064 39.1%

Adults 20-49 0.014350 50.7%

Adults 50-99 0.014768 52.2%

Female 13-49 0.014516 51.3%

-------------------------------------------------------------------------------
Fenamidone Dietary Exposure and Risk Assessment DP Number: D416496

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Attachment 2. Fenamidone Acute Dietary Risk Assessment Results File

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for FENAMIDONE NHANES 2003-2008 2-Day

Residue file: FENAMIDONE ACUTE AND CHRONIC F_W041311.R08

Adjustment factor #2 NOT used.

Analysis Date: 11-19-2013/12:10:42 Residue file dated: 11-19-2013/12:06:01

NOEL (Acute) = 125.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

Run Comment: "100x uncertainity factor for acute and chronic; 1x FQPA safety f

actor for acute and chronic; EDWC "

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Total US Population:

 0.042858 3.43 2916 0.083286 6.66 1500 0.159846 12.79 782 

All Infants:

 0.049122 3.93 2544 0.078634 6.29 1589 0.328697 26.30 380 

Female 13-50:

 0.044191 3.54 2828 0.086806 6.94 1439 0.152918 12.23 817 

Children 1-2:

 0.059469 4.76 2101 0.100903 8.07 1238 0.368654 29.49 339 

Children 3-5:

 0.058441 4.68 2138 0.122948 9.84 1016 0.212424 16.99 588 

Children 6-12:

 0.035464 2.84 3524 0.083108 6.65 1504 0.159590 12.77 783 

Youth 13-19:

 0.030767 2.46 4062 0.059223 4.74 2110 0.124518 9.96 1003 

Adults 20-49:

 0.042344 3.39 2952 0.081206 6.50 1539 0.145666 11.65 858 

Adults 50-99:

 0.043906 3.51 2846 0.082755 6.62 1510 0.156961 12.56 796 

Female 13-49:

 0.044264 3.54 2823 0.087130 6.97 1434 0.151727 12.14 823 
Fenamidone Dietary Exposure and Risk Assessment DP Number: D416496

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Attachment 3. Acute and Chronic Food plus Water Residue Input file.

The residue input file used was the same for acute and chronic analyses, however the reference doses were 

different; 0.0283 mg/kg bw/day for chronic analysis and 125 mg/kg bw/day for acute.

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FENAMIDONE

Residue file: C:\Documents and Settings\kmilians\Desktop\MODELS\DEEM\FENAMIDONE ACUTE AND 

CHRONIC F_W041311.R08

 Adjust. #2 NOT used

Analysis Date 11-21-2013 Residue file dated: 11-19-2013/13:26:57

Reference dose (RfD) = 0.0283 mg/kg bw/day

Comment:100x uncertainity factor for acute and chronic; 1x FQPA safety factor for acute and 

chronic; EDWC

----------------------------------------------------------------------------------

Food Crop Residue Adj.Factors

EPA Code Grp Food Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------

0401005000 4A Amaranth, leafy 32.550000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.080000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.080000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.080000 1.000 1.000 

0401018000 4A Arugula 32.550000 1.000 1.000 

0902021000 9B Balsam pear 0.158000 1.000 1.000 

1500025000 15 Barley, pearled barley 0.594000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 0.594000 1.000 1.000 

1500026000 15 Barley, flour 0.594000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 0.594000 1.000 1.000 

1500027000 15 Barley, bran 0.594000 1.000 1.000 

0603030000 6C Bean, black, seed 0.520000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.520000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.520000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.520000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.520000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.520000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.520000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.520000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.520000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.520000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.520000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.520000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.520000 1.000 1.000 

3100044000 31 Beef, meat 0.150000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.150000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.150000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.150000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.150000 1.000 1.000 

3100047000 31 Beef, fat 0.150000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.150000 1.000 1.000 

3100048000 31 Beef, kidney 0.150000 1.000 1.000 

3100049000 31 Beef, liver 0.150000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.150000 1.000 1.000 

0101050000 1AB Beet, garden, roots 0.180000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 0.180000 1.000 1.000 

0501061000 5A Broccoli 3.270000 1.000 1.000 

0501061001 5A Broccoli-babyfood 3.270000 1.000 1.000 

0501062000 5A Broccoli, Chinese 3.270000 1.000 1.000 

0502063000 5B Broccoli raab 32.990000 1.000 1.000 

0501064000 5A Brussels sprouts 0.740000 1.000 1.000 

1500065000 15 Buckwheat 0.594000 1.000 1.000 

1500066000 15 Buckwheat, flour 0.594000 1.000 1.000 

0101067000 1AB Burdock 0.180000 1.000 1.000 

0501069000 5A Cabbage 0.740000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 32.990000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 0.740000 1.000 1.000 
Fenamidone Dietary Exposure and Risk Assessment DP Number: D416496

Page 12 of 14

0501072000 5A Cabbage, Chinese, mustard 3.270000 1.000 1.000 

0901075000 9A Cantaloupe 0.158000 1.000 1.000 

0402076000 4B Cardoon 20.160000 1.000 1.000 

0101078000 1AB Carrot 0.180000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.180000 1.000 1.000 

0101079000 1AB Carrot, juice 0.180000 1.000 1.000 

0103082000 1CD Cassava 0.080000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.080000 1.000 1.000 

0501083000 5A Cauliflower 3.270000 1.000 1.000 

0101084000 1AB Celeriac 0.180000 1.000 1.000 

0402085000 4B Celery 20.160000 1.000 1.000 

0402085001 4B Celery-babyfood 20.160000 1.000 1.000 

0402086000 4B Celery, juice 20.160000 1.000 1.000 

0402087000 4B Celtuce 20.160000 1.000 1.000 

0902088000 9B Chayote, fruit 0.158000 1.000 1.000 

0603098000 6C Chickpea, seed 0.520000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.520000 1.000 1.000 

0603099000 6C Chickpea, flour 0.520000 1.000 1.000 

0101100000 1AB Chicory, roots 0.180000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.158000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 32.550000 1.000 1.000 

0502117000 5B Collards 32.990000 1.000 1.000 

1500120000 15 Corn, field, flour 0.218000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.218000 1.000 1.000 

1500121000 15 Corn, field, meal 0.218000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.218000 1.000 1.000 

1500122000 15 Corn, field, bran 0.218000 1.000 1.000 

1500123000 15 Corn, field, starch 0.218000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.218000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.218000 1.000 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.218000 1.000 1.000 

1500125000 15 Corn, field, oil 0.218000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.218000 1.000 1.000 

1500126000 15 Corn, pop 0.594000 1.000 1.000 

1500127000 15 Corn, sweet 0.218000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.218000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.080000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.080000 1.000 1.000 

0401133000 4A Cress, garden 32.550000 1.000 1.000 

0401134000 4A Cress, upland 32.550000 1.000 1.000 

0902135000 9B Cucumber 0.158000 1.000 1.000 

0401138000 4A Dandelion, leaves 32.550000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.080000 1.000 1.000 

0802148000 8BC Eggplant 0.260000 1.000 1.000 

0401150000 4A Endive 32.550000 1.000 1.000 

0402152000 4B Fennel, Florence 20.160000 1.000 1.000 

0301165000 3A Garlic, bulb 0.186000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.186000 1.000 1.000 

0101168000 1AB Ginseng, dried 1.190000 1.000 1.000 

3200169000 32 Goat, meat 0.150000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.150000 1.000 1.000 

3200171000 32 Goat, fat 0.150000 1.000 1.000 

3200172000 32 Goat, kidney 0.150000 1.000 1.000 

3200173000 32 Goat, liver 0.150000 1.000 1.000 

1304175000 13D Grape 0.896000 1.000 1.000 

1304176000 13D Grape, juice 0.896000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 0.896000 1.000 1.000 

9500177000 O Grape, leaves 0.896000 1.000 1.000 

9500178000 O Grape, raisin 0.896000 4.300 1.000 

1304179000 13D Grape, wine and sherry 0.896000 1.000 1.000 

0603182000 6C Guar, seed 0.520000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.520000 1.000 1.000 

0901187000 9A Honeydew melon 0.158000 1.000 1.000 

3300189000 33 Horse, meat 0.150000 1.000 1.000 

0101190000 1AB Horseradish 0.180000 1.000 1.000 

0502194000 5B Kale 32.990000 1.000 1.000 

0501196000 5A Kohlrabi 0.740000 1.000 1.000 
Fenamidone Dietary Exposure and Risk Assessment DP Number: D416496

Page 13 of 14

0302198000 3B Leek 1.234000 1.000 1.000 

0603203000 6C Lentil, seed 0.520000 1.000 1.000 

0401204000 4A Lettuce, head 11.790000 1.000 1.000 

0401205000 4A Lettuce, leaf 17.580000 1.000 1.000 

3800221000 38 Meat, game 0.150000 1.000 1.000 

3600222000 36 Milk, fat 0.030000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.030000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.030000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.030000 1.000 1.000 

3600224000 36 Milk, water 0.030000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.030000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.030000 1.000 1.000 

1500226000 15 Millet, grain 0.594000 1.000 1.000 

0502229000 5B Mustard greens 32.990000 1.000 1.000 

1500231000 15 Oat, bran 0.594000 1.000 1.000 

1500232000 15 Oat, flour 0.594000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 0.594000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 0.594000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 0.594000 1.000 1.000 

0802234000 8BC Okra 1.780000 1.000 1.000 

0301237000 3A Onion, bulb 0.186000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.186000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.186000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.186000 9.000 1.000 

0302239000 3B Onion, green 1.234000 1.000 1.000 

0401248000 4A Parsley, leaves 32.550000 1.000 1.000 

0101250000 1AB Parsley, turnip rooted 0.180000 1.000 1.000 

0101251000 1AB Parsnip 0.180000 1.000 1.000 

0101251001 1AB Parsnip-babyfood 0.180000 1.000 1.000 

0602255000 6B Pea, succulent 0.520000 1.000 1.000 

0602255001 6B Pea, succulent-babyfood 0.520000 1.000 1.000 

0603256000 6C Pea, dry 0.520000 1.000 1.000 

0603256001 6C Pea, dry-babyfood 0.520000 1.000 1.000 

0601257000 6A Pea, edible podded, succulent 0.520000 1.000 1.000 

0603258000 6C Pea, pigeon, seed 0.520000 1.000 1.000 

0602259000 6B Pea, pigeon, succulent 0.520000 1.000 1.000 

0802270000 8B Pepper, bell 0.260000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.260000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.260000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.260000 1.000 1.000 

0802272000 8BC Pepper, nonbell 1.780000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 1.780000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 1.780000 1.000 1.000 

0103296000 1C Potato, chips 0.080000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.104000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.104000 1.000 1.000 

0103298000 1C Potato, flour 0.104000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 0.104000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.080000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.080000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.080000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.080000 1.000 1.000 

0902308000 9B Pumpkin 0.158000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.158000 1.000 1.000 

3900312000 39 Rabbit, meat 0.150000 1.000 1.000 

0401313000 4A Radicchio 11.790000 1.000 1.000 

0101314000 1AB Radish, roots 0.180000 1.000 1.000 

0101316000 1AB Radish, Oriental, roots 0.180000 1.000 1.000 

0502318000 5B Rape greens 32.990000 1.000 1.000 

0402322000 4B Rhubarb 20.160000 1.000 1.000 

0101327000 1AB Rutabaga 0.180000 1.000 1.000 

1500328000 15 Rye, grain 0.594000 1.000 1.000 

1500329000 15 Rye, flour 0.594000 1.000 1.000 

0101331000 1AB Salsify, roots 0.180000 1.000 1.000 

3500339000 35 Sheep, meat 0.150000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.150000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.150000 1.000 1.000 
Fenamidone Dietary Exposure and Risk Assessment DP Number: D416496

Page 14 of 14

3500341000 35 Sheep, fat 0.150000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.150000 1.000 1.000 

3500342000 35 Sheep, kidney 0.150000 1.000 1.000 

3500343000 35 Sheep, liver 0.150000 1.000 1.000 

1500344000 15 Sorghum, grain 0.594000 1.000 1.000 

1500345000 15 Sorghum, syrup 0.594000 1.000 1.000 

0600347000 6 Soybean, seed 0.232000 1.000 1.000 

0603348000 6C Soybean, flour 0.232000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.232000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.232000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.232000 1.000 1.000 

0600350000 6 Soybean, oil 0.232000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.232000 1.000 1.000 

0401355000 4A Spinach 32.550000 1.000 1.000 

0401355001 4A Spinach-babyfood 32.550000 1.000 1.000 

0902356000 9B Squash, summer 0.158000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.158000 1.000 1.000 

0902357000 9B Squash, winter 0.158000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.158000 1.000 1.000 

1307359000 13G Strawberry 0.252000 1.000 1.000 

1307359001 13G Strawberry-babyfood 0.252000 1.000 1.000 

1307360000 13G Strawberry, juice 0.252000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 0.252000 1.000 1.000 

2002364000 20B Sunflower, seed 0.080000 1.000 1.000 

2002365000 20B Sunflower, oil 0.080000 1.000 1.000 

2002365001 20B Sunflower, oil-babyfood 0.080000 1.000 1.000 

0103366000 1CD Sweet potato 0.080000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.080000 1.000 1.000 

0402367000 4B Swiss chard 20.160000 1.000 1.000 

0103371000 1CD Tanier, corm 0.080000 1.000 1.000 

0801374000 8A Tomatillo 0.860000 1.000 1.000 

0801375000 8A Tomato 0.860000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.860000 1.000 1.000 

0801376000 8A Tomato, paste 2.880000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 2.880000 1.000 1.000 

0801377000 8A Tomato, puree 1.779000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 1.779000 1.000 1.000 

0801378000 8A Tomato, dried 0.860000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.860000 14.300 1.000 

0801379000 8A Tomato, juice 0.860000 1.500 1.000 

1500381000 15 Triticale, flour 0.594000 1.000 1.000 

1500381001 15 Triticale, flour-babyfood 0.594000 1.000 1.000 

0103387000 1CD Turmeric 0.080000 1.000 1.000 

0101388000 1AB Turnip, roots 0.180000 1.000 1.000 

0502389000 5B Turnip, greens 32.990000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.207000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.207000 1.000 1.000 

0901399000 9A Watermelon 0.158000 1.000 1.000 

0901400000 9A Watermelon, juice 0.158000 1.000 1.000 

1500401000 15 Wheat, grain 0.594000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.594000 1.000 1.000 

1500402000 15 Wheat, flour 0.594000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.594000 1.000 1.000 

1500403000 15 Wheat, germ 0.594000 1.000 1.000 

1500404000 15 Wheat, bran 0.594000 1.000 1.000 

0103406000 1CD Yam, true 0.080000 1.000 1.000 

0103407000 1CD Yam bean 0.080000 1.000 1.000 

0301338000 3A Shallot, bulb 0.186000 1.000 1.000