## UNITED S TA TES ENV IRONM ENT AL PR OTECT IO N AGENC Y WASHINGTON, D.C. 20460

Of-TICE OF CHEM I CAL SAFETY AND POLLUTION PREVENTION



## M EM ORAND UM



## DA TE: D ecembe r 21
, 20 15

SUBJECT: Tetrach l orvinphos: 

## Occupational and Residential Exposure Assessment for Re gis tration Review

PC Co d e : 

## 08370 I
, 

## 083702 Petition No.: 

## NA DP Barcode: 

## D426984 R eg i s tration Nos.: 

## NA Ri s k Assessment T y pe: Regulatory Act i on: 

## Regi s tration Revi ew Occupational/Resident i a l Expos ure Assessment TXR No

. : 

## NA Case No.: 

## NA MRID No.: 

## 42622301 CAS No .: 

## 22248

- 79-9

FROM: Wade Britton, MPH, Environmental Health Scientist Risk Assessment Branch V (RABY) Health Effects Division ( H ED; 7509P) Office of P est icide Programs

THROUGH: Michael Metzger, Chief

# ~**~~** RABY a nd RABVII/HED (7509P) And**~** 

## Cassi Walls, Reviewer

# ~**~** 

# -f1l 

# r Zaida Figueroa, Reviewer 

# ,,./;&1;u 1 

# l
, //

_ Exposure Science Advisory

## Co~~rtte~ (iExpoSAC) I 

## HED

TO: Neil Anderson, Branch Ch i ef

Introduction 

## James Park e r , C hemical R ev i ew Manage r Risk Management and Impl ementation Branch I (RMIBI) Pesticide Re-evaluation Division ( PRO ; 7508P) Office of Pesticide Pro grams

As part of Registration Review, the Pesticide-Re-evaluation Division (PRO) of OPP h as requested that the H ea lth Effects Divi s ion ( HED) conduct an occupationa l and residential exposu r e assessment, as ne eded, to estimate the risk to human health that will r es ult from th e currently registered uses of tetrachlorvinphos (TCVP) in support of registration of r eview for the chemica l. A residential exposure assessment for a ll pet uses of tetrachlorvinphos was previously
Page 1 

## of 124

## Page 2 of 124

conducted 1 

## in response to a Natural Resources Defense Council (NRDC) petition for the Agency to cancel all pet uses of TCVP.
It is HED policy to use the best available data to assess exposure. Several sources of generic data were used in this assessment as surrogate data in the absence of chemical

- specific data, including the Pesticide Handlers Exposure Database Version 1.1 ( PHED 1.1 ) ; the Agricultural Handler Exposure Task Force (AHETF) databa se; the Residential SOPs (Treated Pets); as well as a TCVP dust/powder applicator exposure study (MRID 45519601) , a TCVP dust and pump

s pray study (MRID 45485501)
, and an amitraz pet collar residue transfer study (MRID 49468801)

. Some of these data are proprietary, and subject to the data protection provisions of the Federal Insecticide, Fungicide, and Rodenticide Act ( FIFRA).
Data were also used from a literature study using TCVP pet collars
, Davis, M

. et. al., Assessing Intermittent Pesticide Exposure from Flea Control Collars Containing the Organophosphorus Insecticide Tetrachlorvinphos. Journal of Exposure Science and Envir onmental Ep idemiology. (2008) 18, 564

- 57). That study is currently undergoing internal EPA science and ethics review and will also undergo review by the HSRB at the next scheduled HSRB meeting, January 2016.

Note: This memorandum was reviewed by the E xposure Science Advisory Committee (ExpoSAC ) on May 21 , 2015.

1 

### W. Britton. Residential Exposure Assessment in Response to the Natural Resources Defense Council Petition to Cancel All Pet Uses for Tetrachlorvinphos . 11/05/2014. D420283.

## Page 3 of 124



# Table of Contents
1.0 Executive Summary

................................ ................................ ................................ ............. 4
2.0 Risk Assessment Conclusions and Recommendations

................................ ...................... 10
2.1 Summary of Risk Estimates

................................ ................................ ........................... 10
3.0 Hazard Characterization and Dose

- Response Assessment

................................ ................ 12
4.0 Use Profile

................................ ................................ ................................ ......................... 17
5.0 Residential Exposure and Risk Estimates

................................ ................................ .......... 18
5.1 Residential Handler Exposures

................................ ................................ ...................... 18
5.2 Residential Post

- application Exposure/Risk Estimates

................................ .................. 20
5.3 Residential Risk Estimates for Use in Aggregate Assessment

................................ ...... 28
5.4 Spray Drift

................................ ................................ ................................ ...................... 28
5.5 Residential Bystander Post

- Application Inhalation Exposure

................................ ....... 28
6.0 Occupational Exposure and Risk Estimates

................................ ................................ ...... 29
6.1 Occupational Handler Exposure/Risk Estimates

................................ ............................ 29
6.2 Occupational Post

- application Exposure/Risk Estimates

................................ .............. 35 Appendix A: Summary of OPP’s ChE Policy & Use of BMD Modeling

................................ ... 36 Appendix B: Results for BMD/BMDL modeling for TCVP

................................ ....................... 37 Appendix C

– Summary of TCVP Labels and Use Directions

................................ ..................... 38 Appendix D: Summary of Occupational and Residential Non

- cancer Algorithms

..................... 55 Occupational and Residential Cancer Algorithms

................................ ................................ ........ 59 Appendix E

– Summary of Residential Handler Exposures and Risks

................................ ........ 61 Appendix F

– Summary of Residential Handler Cancer Exposure and Risk Estimates

............... 67 Appendix G

– Summary of Residential Post

- Application Non

- Cancer Exposure and Risk Estimates

................................ ................................ ................................ ................................ ....... 69 Appendix H

– Summary of Residential Post

- Application Cancer Exposure and Risks

............... 77 Appendix I

– Summary of Occupational Handler Exposures and Risks

................................ ...... 81 Appendix J

– Summary of Occupational Handler Cancer Risk Estimates

................................ ... 95

## Page 4 of 124

1.0 Executive Summary

TCVP [ (Z)

- 2

- chloro

- 1

- (2,4,5

- trichlorophenyl) vinyl dimethyl phosphate] is a member of the organophosphate (OP) class of pesticides. TCVP is used as a direct animal treatment to livestock (i.e., cattle, horses, poultry and swine) and their premises, in kennels
, outdoors as a perimeter treatment , and as a flea treatment on cats and dogs. There are 42 end

- use product labels currently registered with TCVP as the active ingredient (ai). This assessment updates the occupational exposures anticipated from the livestock, outdoor perimeter treatment, and pet uses. The assessment of all occupational uses of TCVP have been updated since the dermal and inhalation levels of concern ( LOCs ) have increase d 10 fold , and du e to significant changes in scenario

- specific handler surrogate exposure data that have occurred since most recent assessments were conducted in 2002. All currently registered TCVP pet products were recently assessed in the above cited 11/2014 residential risk assessment and include collar, dust/powder, and pump and t rigger spray formulations. The risk outcomes (presented herein) of the 11/2014 residential assessment have been reevaluated for the following reasons:

 Inclusion of the 10X FQPA safety factor/uncertainty factor ;

 There is no non

- cancer dermal hazard for TCVP;

 A female

- specific body weight, 69 kg, is used for assessment of adult (inhalation) exposures instead of the average adult body weight of 80 kg;

 Use of newer pet residue data for pet collars that result in more conservative estimates of residue transfer and exposure than the data used in the 2014 risk assessment. Residential post

- application assessments for TCVP pet collar uses are performed using data from two recently submitted pet collar residue transfer studies (an amitraz pet collar study 2 

## (herein referred to as “the amitraz study”) and a literature study using TCVP pet collars (Davis, 2008 3 

## , herein referred to as “the Davis study”) ; and

 Because it cannot be confirmed at this tim e if TCVP pet collar products are manufactured as liquid or dust formulations, the exposures to TCVP pet collar products are assessed 1) assuming all collars may be a liquid formulation and 2) assuming all collars may be a dust formulation.

Further, this document takes into account, where appropriate, arguments presented in the Natural Resources Defense Council, Inc.’s (NRDC) Aug. 5, 2015 Opening Brief in NRDC v. EPA , Case No. 15

- 70025 (9 th 

## Cir.) (Opening Brief), which was filed as a result o f the 2014 residential pet product assessment and EPA’s subsequent denial of NRDC’s 2009 petition to cancel all TCVP pet products

. 4 

## The EPA point

- by

- point response to NRDC comments can be found in D430589. 5

2 

### MRID 49468801: Determination of Transferable Residues of Amitraz from the H air of Dogs Following the Application of the Preventic® Collar

. 3 

### Davis, M. et. al., Assessing Intermittent Pesticide Exposure from Flea Control Collars Containing the Organophosphorus Insecticide Tetrachlorvinphos . Journal of Exposure Science and Environ mental Epidemiology. (2008) 18, 564

- 57)
4 

### Natural Resources Defense Council, Inc., Petitioner, v. U.S. Environmental Protection Agency, Respondent. On Petition to Review of an Order of the U.S. Environmental Protection Agency. In the United State Court o f Appeals for the Ninth Circuit. 8/5/2015. No. 15

- 70025.
5 

### W. Britton

. Tetrachlorvinphos (TCVP): Responses to Arguments Presented in the Natural Resources Defense Council , Inc.’s (NRDC) Aug. 5, 2015 Opening Brief in NRDC v. EPA , Case No. 15

- 70025 (9 th 

### Ci r.). 12/21/15, D430589

.

## Page 5 of 124

The arguments addressed include:

 EPA incorrectly eliminated a key safety factor mandated by Congress to protect children;

 W ithout a chemical

- specific study to assess post

- application risks , EPA should have used the default F AR 

## (i.e., residue transfer) of two percent as recommended by the 2012 Standard Operating Procedures (SOPs) for Residential Pesticide Exposure Assessment 6 

## (hereinafter, “2012 Residential SOPs”) to assess risks from pet collar exposures ;

 EPA failed to consider the Davis study for the estimation of post

- application risks for

e xposures to the TCVP flea collar;

 EPA incorrectly considered the TCVP flea collar to be liquid formulated product;

 EPA underestimates children’s post

- application exposures to their pets through use of an assumption that toddlers spend one hour per day wit h their pets ;

 EPA failed to account for an established route of post

- application exposure, toddlers who touch an object or food with pesticide

- contaminated hands, and then put that object or food into his/her mouth ( i.e., object

- to

- mouth exposures ); and

 EPA’s algorithm for calculating the amount of “transferable residue” is inconsistent with the findings of the Davis study which found that the residues were concentrated at the neck of the animal following application.

Exposure and Proposed Use Profile
Occupational handler exposures are anticipated from the use of TCVP in livestock, as an outdoor perimeter treatment, and on pets. The TCVP livestock and perimeter treatment uses are formulated as follows : dusts (D), emulsifiable concentrates (EC), feed t hrough (solid and liquid food additives), feed blocks, and wettable powders (WP). The personal protective equipment (PPE) required for occupational use of TCVP vary by formulation and application/equipment type . For feed through (solid and liquid food ad ditives) and feed blocks, occupational handlers are required to wear baseline clothing (i.e., long sleeved shirt, long pants, shoes and socks) and gloves. For all other end

- use labels with livestock and outdoor perimeter use s , required PPE can vary dependent on the application / equipment type and range from baseline clothing and gloves, to the addition of covera lls, or respiratory protection (i.e, PF5 or PF10 respirators)

. Occupational handler exposures are also expected from use of TCV P on pets by veterinarians, veterinary assistants, and groomers. The pet use formulations include collars, dusts/powders, and pump and trigger sprays. All but one of the TCVP pet product label s do not require PPE (i.e., EPA Reg No. 47000

- 123 which require s double layer clothing, gloves and dust mist respirator) as these ar e intended for residential sale as well as for occupational use. A summary of all TCVP occupational use sites and application rates is presente d in Appendix C

. Occupational post

- application exposures are not anticipated for TCVP based on the manner in which it is applied. Further, restricted entry intervals (REIs) are not included on TCVP product labeling as the registered uses (i.e., livestock or other animals, or in or around animal premises) are not covered by the Worker Protection Standard (WPS).

6 

### Available: http://www2.epa.gov/pesticide

- science

- and

- assessing

- pesticide

- risks/standard

- operating

- procedures

residential

- pesticide

## Page 6 of 124

Residential handler and post

- application exposures are anticipated from the use of TCVP pet products and were previously assessed

.
Hazard

TCVP is a member of the OP class of pesticides. For TCVP, like other OPs, the initiating event in the adverse outcome pathway/mode of action (AOP/MOA) involves inhibition of the enzyme acetylcholinesterase (AChE) via phosphorylation of the serine residue at the active site of the enzyme. This inhibition leads to accumulation of acetylcholine and ultimately to neurotoxicity in the central and/or peripheral nervous system . For TCVP, AChE inhibition is the most sensiti ve endpoint in the toxicology database in multiple species, durations, lifestages, and routes. TCVP does not require metabolic activation to an oxon to inhibit AChE; i.e. , the parent compound is the active form inhibiting AChE. OPs also exhibit a phenome non known as steady state AChE inhibition. After repeated dosing at the same dose level, the degree of inhibition comes into equilibrium with the production of new, uninhibited enzyme. OP AChE studies of 2

- 3 weeks generally show the same degree of inhibi tion as those of longer duration ( i.e. , up to 2 years of exposure). Therefore, a steady state assessment based on 21 days of exposure may be conducted in place of the traditional chronic or long

- term assessments. The steady state point of departure is pr otective of any exposure duration longer than 21

- days, including chronic exposure, since cholinesterase inhibition does not increase after reaching maximum inhibition or steady state
The toxicology database for TCVP is complete for risk assessment. TCVP has cholinesterase data across multiple lifestages, durations, and routes for both red blood cell (RBC) and brain cholinesterase inhibition. There are acceptable studies available for toxicity endpoint and point of departure (POD) selection. For TCVP, RB C AChE inhibition is the most sensitive endpoint and is the endpoint from which the PODs for all TCVP exposure routes and durations were selected.
There is no evidence of quantitative or qualitative sensitivity in the developmental rat and rabbit study or in the gestational (fetus) or juvenile (postnatal day; PND11) components of the comparative cholinesterase assay (CCA) study. In the acute and repeated comparative cholinesterase assays, juvenile rats (PND 11 and PND 21), pregnant dams, fetuses, and no n

pregnant females show similar results in both RBC and brain AChE activity. At the lowest tested dose of 75 mg/kg/day in the acute CCA study, there was little difference in RBC or brain AChE inhibition between the PND11, PND21, or young adult (PND42). S imilarly, the PND11 and PND21 rats in the CCA study are similarly sensitive as adult rats exposed to a single dose of 50 mg/kg from a separate peak inhibition study. The repeat dosing phase of the CCA also demonstrates the lack of sensitivity in AChE inhi bition in the juvenile (PND11) rats. Furthermore, the fetus is not more sensitive than the pregnant dam. Therefore, points of departure that are based on adult AChE data are also protective of the postnatal and gestational lifestages.
High quality AChE data for the dermal and inhalation routes are also available and allow for route specific evaluation. RBC AChE inhibition was observed in both sexes in the inhalation study (brain AChE was not assessed), while no inhibition of RBC or brain AChE was observ ed in the dermal study up to the limit dose.

## Page 7 of 124

TCVP is classified as a Group C possible human carcinogen ( based on statistically significant increases in combined hepatocellular adenoma/carcinoma in female mice) with a linear low

- dose approach for quantifi cation of risk using the oral slope factor (Q1*) of 1.83 x 10

- 3 

## (mg/kg/day)

- 1



## . Whereas parent compound TCVP is the residue of concern for AChE inhibition, TCVP plus metabolites containing the 2,4,5 trichlorobenzene moiety are the residues of concern for ca ncer assessment.
Uncertainty Factors
For TCVP, as for other OPs, the FQPA safety factor (SF) of 10X has been retained for infants, children, youths, and women of childbearing age for all exposure scenarios due to uncertainty in the human dose

- response relationship for neurodevelopmental effec ts.
A total uncertainty factor of 1000X is appropriate for residential incidental oral exposures (10X for interspecies extrapolation, 10X for intraspecies variation, and a 10X FQPA SF). A total uncertainty factor of 300X is appropriate for all inhalatio n exposures (3X for interspecies extrapolation, 10X for intraspecies variation, and a 10X FQPA SF for residential assessments or a 10X database uncertainty factor for occupational assessments to protect potentially pregnant female workers due to uncertaint y in the human dose

- response relationship for neurodevelopmental effects. 7



## Residential Exposure and Risk
Residential exposures (handler and post

- application) are anticipated from the use of TCVP pet products. All currently registered TCVP pet products were updated in the 11/2014 residential risk assessment. As stated previously, the risk outcomes of the 11/2014 residential assessment have been reevaluated due to the determination of no dermal hazard for TCVP, the incidental

ora l and inhalation LOCs have increase d 10 fold since the assessment was conducted , and the presentation of preliminary, comparative residential post

- application risks from contact with pets treated with the pet collar formulation with use of th e Davis study

. Residential TCVP handler and post

- application exposures are anticipated to be short

- (1 to 30 days) to intermediate

- term (1 to 6 months) in duration. However, because of the steady state AChE inhibition exhibited by the OPs, steady state e xposures (21 days and longer) were assessed and presented for residential exposures to TCVP pet products.

Handler Dust/Powder and Pump/Trigger Spray : All r eside ntial handler (adults) non

- cancer steady state inhalation risk s estimated for the TCVP pet dust/powder and pump/trigger spray formulations are not of concern to the Agency (i.e., all MOEs are > 300 ). Residential handler estimated cancer risks (combined dermal and inhalation) for TCVP dusts/powders range from 10

- 8 

## to 10

- 7 

## , and for pump/trigger sprays range from 10

- 9 

## to 10

- 8



## .

7 

### For more information, please reference Sections 4.4 and 4.5 of the Tetrachlorvinphos Human Health Draft Risk Assessment for Registration Review. D. Drew. D411095. 12/21/2015.

## Page 8 of 124

Pet Collars: Because there is uncertainty whe ther the TCVP pet collars are liquid and/ or dust formulated product s , residential handler stead y state inhalation exposures were quantified and presented assuming collars cou ld be either formulation

. No handler risks of concern were identified with the use of either liquid

- specific UE data (i.e., surrogate data from spot

- on applicator study) or with use of dust

- specific UE data (i.e., a 

## TCVP dust/powder applicator exposure study ). Residential handler dermal risks for all TCVP pet products have not been assessed due to the finding of no dermal hazard for TCVP.

Residential handler cancer risks estimated for TCVP estimated with use of liquid

- specific UE data are all 10

- 8 

## , a nd with use of the dust

- specific UE data cancer are all 10

- 7



## .

Post

- application Since there is no non

- cancer dermal hazard for TCVP and post

- application inhalation exposures to treated pets are negligible, a quantitative non

- cancer post

- application expos ure assessment was not performed for adults; there are no residential non

- cancer risk estimates of concern for adults contacting pets treated with TCVP products. Dust/Powder and Pump/Trigger Spray : Residential post

- application steady state non

- cancer chil d 1 to < 2 years old incidental oral (hand

- to

- mouth) exposures to pets treated with TCVP pump/trigger sprays are not estimated to be of concern (i.e., MOEs are > 1,000). However, child 1 to < 2 years old incidental oral exposures to pets treated with TCVP dust/powder products are estimated to be of concern for 14 of 17 total exposure scenarios assessed (i.e., MOEs are < 1,000). Residential cancer (adult only ) risks estimated for TCVP pump/trigger sprays range from 10

- 7 

## to 10

- 6 

## and, for TCVP dust/powder pr oducts estimated cancer risks are 10

- 7



## .
Pet Collars: As was noted above, newer residue transfer data, that indicated higher residue transfer than the data used in the 2014 assessment, were used to reassess post

- application exposures to TCVP pet collars. The post

- application assessments for the TCVP pet collars were performed assuming pet collars could be either liquid or solid (dust) formulations, and using residue transfer data from two available studies (the amitraz study and the Davis study). Data f rom both studies have been included because the Davis study is currently undergoing internal EPA science and ethics review and will also undergo review by the Human Studies Review Board (HSRB) at the next scheduled HSRB meeting, January 2016. Until the Da vis study undergoes a complete review by the HSRB, any assumptions, risk estimates or conclusions using the Davis study are considered preliminary. If the Davis study is determined to be acceptable for use in risk assessment, these TCVP

- specific data will be relied upon for risk quantitation; alternatively, if these data are determined to be unacceptable for use, the amitraz study may be relied upon as the best available data source unless other appropriate chemical

- specific data become available. The pos t

- application exposure and risk estimates for the various pet collar assumptions are provided below:

Liquid formulation/Amitraz study assumption: Post

- application child non

- cancer incidental oral risk estimates are not of concern (i.e., MOEs are > 1,000; LOC=1000). Estimated adult post

application cancer risks range from 10

- 7 

## to 10

- 6



## . Liquid formulation/Davis study assumption: One of the 23 scenarios assessed (EPA Reg. No. 2596

- 139; exposures to a small sized dog) for post

- application child n on

- cancer incidental oral

## Page 9 of 124

risk is of concern (MOE = 650; LOC=1000). Estimated adult post

- application cancer risks range from 10

- 6 

## to 10

- 5



## . Dust formulation/Amitraz study assumption: Post

- application child non

- cancer incidental oral risk estimates are of concern for all of the TCVP pet collar exposure scenarios assessed (i.e., MOEs are < 1,000; LOC=1000). All estimated adult post

- application cancer risks are estimated to be 10

- 5



## .

Dust formulation/Davis study assumption: Quantitative assessments w ere not performed assuming collars are dust formulations and using the Davis study since the mean residue transfer measured in the Davis study was greater than that in the amitraz study; therefore, post

application exposures from TCVP pet collars would be greater, and MOEs lower, when using the Davis study than those resulting from using the amitraz study (which are of concern for children).

A quantitative residential post

- application inhalation exposure assessment was not performed as inhalation exposure is expected to be negligible from applications to pets. However, an inhalation exposure assessment was performed for pet handlers (i.e., veterinarians, veterinary assistants, and groomers ) and this exposure scenario should be considered protective of any potential low

- level post

- application inhalation exposure that could result from these types of applications

. Spray Drift A quantitative spray drift a ssessment was not conducted because the use of TCVP for direct animal treatment to livestock and their premises, in kennels, outdoors as a perimeter treatment, and as a flea treatment on cats and dogs are either 1) not applied via aircraft, groundboom, or airblast equipment or 2) for applications to poultry bui ldings with groundboom equipment, the use is indoors and not anticipated to be a significant source of spray drift.

Occupational Exposure and Risk
Steady state non

- cancer and cancer exposures and risk s were calculated for occupational handlers of TCVP . In order to determine what level of personal protection is required to alleviate risk concerns and to ascertain if label modifications are needed, steady state exposure and risk estimates were calculated for occupational handlers of TCVP for a variety o f exposure scenarios at differing levels of personal protection including engineering controls.
Of the 172 total occupational handler exposure scenarios assessed, the majority (152) are not of concern (i.e., steady state inhalation MOEs are ≥ 300) with currently required personal protective equipment (PPE) (i.e., respiratory protection). Of the remaining 20 handler exposure scenarios, an additional 16 are not of concern with consideration of increasing levels of respiratory protection (i.e., four occupa tional handler exposure scenarios result in estimated risks of concern despite the addition of respiratory protection or engineering controls).

## Page 10 of 124

Occupational cancer risks were estimated for both private/farmer and contra ct/commercial handlers. Cancer ri sks range from 10

- 10 

## to 10

- 5 

## for private/farmer handlers and from 10

- 10 

## to 10

- 4 

## for contract/commercial handlers with currently required PPE.

O ccupational post

- application exposures are not anticipated for T C VP as the majority of use sites are not to foliar surfaces (e.g., poultry house, livestock or pet treatments are not considered foliar applications) . The use of TCVP outdoors as a perimeter treatment is not expected to result in occupational post

- application exposure as reentry activities related to crop production (e.g., scouting, harvesting) are not anticipated for this use pattern

.
Human Studies Review
This risk assessment relies in part on data from studies in which adult human subjects were intentionally exposed to a pesticide or other chemical. These data, which include studies from PHED 1.1; the AHETF database; the Outdoor Residential Exposure Task Force (ORETF) database; the ARTF database; the Residential SOPs (Treated Pets); as well as a TCVP dust/powder applicator exposure study (M RID 45519601), and TCVP dust and pump spray study (MRID 45485501) and an amitraz pet collar residue transfer study (MRID 49468801) are (1) subject to ethics review pursuant to 40 CFR 26, (2) have received that review, and (3) are compliant with applicable ethics requirements. For certain studies, the ethics review may have included review by the Human Studies Review Board (HSRB). Descriptions of data sources, as well as guidance on their use, can be found at the Agency website 8



## .
Data were also used fro m a literature study using TCVP pet collars
, Davis, M

. et. al., Assessing Intermittent Pesticide Exposure from Flea Control Collars Containing the Organophosphorus Insecticide Tetrachlorvinphos. Journal of Exposure Science and Environmental Ep idemiology. (2008) 18, 564

- 57). That study is undergoing internal EPA science and ethics review and will also undergo review by the HSRB at the next scheduled HSRB meeting, January 2016.

2.0 Risk Assessment Conclusions and Recommendations

2.1 Summary of Risk Estimates

Residential Handler Dust/Powder and Pump/Trigger Spray : All r eside ntial handler (adults) non

- cancer steady state inhalation risks estimated for the TCVP pet dust/powder and pump/trigger spray formulations are not of concern to the Agency (i.e., all MOEs are > 300). Residential handler estimated cancer risks (combined dermal and inhalation) for TCVP dusts/powders range from 10

- 8 

## to 10

- 7 

## , and for pump/trigger sprays range from 10

- 9 

## to 10

- 8



## .
Pet Collars: No handler risks of concern were identified with the use of either liquid

- specific UE data (i.e., surrogate data from spot

- on applicator study) or with use of dust

- specific UE data (i.e., a 

## TCVP dust/powder applicator exposure study ).

8 

### http://www.epa.gov/pesticides/science/handler

- exposure

- data.html and http://www.epa.gov/pesticides/science/post

- app

- exposure

- data.html

## Page 11 of 124

Residential handler cancer risks estimated for TCVP estimated with use of liquid

- specific UE data are all 10

- 8 

## , and with use of the dust

- specific UE data cancer are all 10

- 7



## .
Residential Post

- application Dust/Powder and Pump/Trigger S pray : Residential post

- application steady state non

- cancer child 1 to < 2 years old incidental oral (hand

- to

- mouth) exposures to pets treated with TCVP pump/trigger sprays are not estimated to be of concern (i.e., MOEs are > 1,000). However, child 1 to < 2 years old incidental oral exposures to pets treated with TCVP dust/powder products are estimated to be of concern for 14 of 17 total exposure scenarios assessed (i.e., MOEs are < 1,000). Residential cancer (adult only) risks estimated for TCVP pump/tri gger sprays range from 10

- 7 

## to 10

- 6 

## and, for TCVP dust/powder products estimated cancer risks are 10

- 7



## .
Pet Collars: Liquid formulation/Amitraz study assumption: Post

- application child non

- cancer incidental oral risk estimates are not of concern (i.e., MOEs are > 1,000; LOC=1000). Estimated adult post

application cancer risks range from 10

- 7 

## to 10

- 6



## . Liquid formulation/Davis study assumption: One of the 23 scenarios assessed (EPA Reg. No. 2596

- 139; exposures to a small sized dog) for post

- application child non

- cancer incidental oral risk is of concern (MOE = 650; LOC=1000). Estimated adult post

- application cancer risks range from 10

- 6 

## to 10

- 5



## . Dust form ulation/Amitraz study assumption: Post

- application child non

- cancer incidental oral risk estimates are of concern for all of the TCVP pet collar exposure scenarios assessed (i.e., MOEs are < 1,000; LOC=1000). All estimated adult post

- application cancer r isks are estimated to be 10

- 5



## .

Dust formulation/Davis study assumption: Quantitative assessments were not performed assuming collars are dust formulations and using the Davis study since the mean residue transfer measured in the Davis study was greate r than that in the amitraz study; therefore, post

application exposures from TCVP pet collars would be greater, and MOEs lower, when using the Davis study than those resulting from using the amitraz study (which are of concern for children).

Occupational Of the 172 total occupational handler exposure scenarios assessed, the majority (152) are not of concern (i.e., steady state inhalation MOEs are ≥ 300) with currently required personal protective equipment (PPE) (i.e., respiratory protection). Of the rem aining 20 handler exposure scenarios, an additional 16 are not of concern with consideration of increasing levels of respiratory protection (i.e., four occupational handler exposure scenarios result in estimated risks of concern despite the addition of res piratory protection or engineering controls).

Occupational cancer risks were estimated for both private/farmer and contract/commercial handlers. Cancer risks range from 10

- 10 

## to 10

- 5 

## for private/farmer handlers and from 10

- 10 

## to 10

- 4 

## for contract/comme rcial handlers with currently required PPE.

## Page 12 of 124

3.0 Hazard Characterization and Dose

- Response Assessment
TCVP is a member of the organophosphate class of pesticides. Like other OPs, the initiating event in the adverse outcome pathway/mode of action (AOP/ MOA) for TCVP involves inhibition of the enzyme AChE via phosphorylation of the serine residue at the act ive site of the enzyme. This inhibition leads to accumulation of acetylcholine and ultimately to neurotoxicity in the central and/or peripheral nervous system (see Figure 1). For TCVP, AChE inhibition is the most sensitive endpoint in the toxicology data base in multiple species, durations, lifestages, and routes. AChE inhibition is the focus of this hazard characterization; the availability of reliable AChE inhibition dose response data is one of the key determinants in evaluating this toxicology databas e.

Figure 1. Adverse outcome pathway for OPs

AChE inhibition is the well

- established cholinergic mode of action for OPs and is typically used as the critical effect in hazard characterization for members of this class of pesticides. TCVP inhibits cholinesterase activity in various species including rats, mice, rabbits, and dogs. TCVP has cholinesterase data across multiple lifestages, durations, and routes for both red blood cell (RBC) and brain cholinesterase inhibition. Cholinesterase inhibition is the most sensitive effect for TCVP; however, TCV P data demonstrate a shallow dose

- response curve for AChE inhibition across many of the studies in the database resulting in varying magnitudes of response across the database. Large increases in administered dose result in only small changes in AChE inhi bition. For example, in the 11

- day repeat adult CCA study, 5 mg/kg and 10 mg/kg resulted in about 10% RBC inhibition, 50 mg/kg from 30

- 40% RBC inhibition, and 200 mg/kg only 40

- 60% inhibition. A similar response was observed in brain AChE with no inhibit ion at 5 mg/kg, 7

- 12% at 10 mg/kg, 15

- 40% at 50 mg/kg, and only 18

- 57% at 200 mg/kg. In the 21

- day repeat toxicity study, 20 mg/kg resulted in approximately 30% RBC inhibition while the highest dose of 50 mg/kg resulted in only 30

- 40% inhibition.

Many o f the toxicological studies for TCVP have been considered for benchmark dose (BMD) modeling (Bever/Holman; 5/20/14 ; TXR# 0056970 and Appendix B). However, a number of datasets were not amenable to BMD modeling due to the shallow dose response described above. Some studies in the database, however, were amenable to BMD modeling and provided a robust evaluation of th e RBC and brain AChE activity. In general, RBC and brain cholinesterase inhibition were similarly inhibited across the database. It should b e noted that is some cases RBC data provided a more robust dose

- response and, therefore, more reliable BMD estimates. Male and female adult rats were also generally affected similarly across the various studies; although sporadically, one sex appears more sensitive; there is no consistent pattern. For example, in the Target Tissue Dose Phosphorylation

of the active site of AChE Neurotoxicity

Accumulation of acetylcholine

## Page 13 of 124

repeat oral subchronic study, adult females were more sensitive (RBC and brain) than adult males, while in the single dose study (MRID 45570601), males were more sensitive (brain) than adult females. High quality AChE data for the dermal and inhalation routes are also available and allow for route specific evaluation. RBC AChE inhibition was observed in both sexes in the inhalation study (brain AChE was not assessed), while no inhibition of RBC or brain AChE was observed in the dermal study up to the limit dose.
Transient clinical signs [gait alterations, constricted pupils, tremors (fore

- and hindlimb), body cool to the touch, decreased defecation, red material on forelimbs, around eyes, n ose, mouth] characteristic of cholinergic toxicity were observed at the high dose (650 mg/kg) in the acute neurotoxicity rat study, and tremors were observed in pregnant rats in the developmental toxicity study at dose levels 5X higher than those eliciting AChE inhibition.

There is no evidence of quantitative or qualitative sensitivity in the developmental rat and rabbit study or in the gestational (fetus) or juvenile (PND11) components of the CCA study. In the acute and repeated comparative cholinesterase assays, juvenile rats (PND 11 and PND 21), pregnant dams, fetuses, and non

- pregnant females show similar results in both RBC and brain AChE activity. At the lowest tested dose of 75 mg/kg/day in the acute CCA study, there was li ttle difference in RBC or brain AChE inhibition between the PND11, PND21, or young adult (PND42). Similarly, the PND11 and PND21 rats in the CCA study are similarly sensitive as adult rats exposed to a single dose of 50 mg/kg from a separate peak inhibiti on study. The repeat dosing phase of the CCA also demonstrates the lack of sensitivity in AChE inhibition in the juvenile (PND11) rats. Furthermore, the fetus is not more sensitive than the pregnant dam. Therefore, points of departure that are based on adult AChE data are also protective of the postnatal and gestational lifestages.

In the rat developmental toxicity study, no developmental effects were observed in the fetus at dose levels where minimal effects (decreased body weight gains) were observe d in the dams. Developmental toxicity (increased early resorptions, post

- implantation loss, and decreased number of live fetuses) was observed in the rabbit developmental toxicity study at the same dose level where significant toxicity (mortality, abortio n) was observed in the maternal rabbit. No reproductive or offspring toxicity was observed in the 2

- generation reproductive rat study, but increased adrenal weights were observed in the parental rats.
In the developmental neurotoxicity study (DNT), quan titative susceptibility was only observed in pups (decreased pup weight, decreased relative brain weight/measurements) at the high dose of 200 mg/kg/day. However, a 200 mg/kg/day dose to juvenile rats is 10

- fold higher than doses reflecting approximately 10% inhibition in juvenile pups in the CCA study and 25

- fold higher than the point of departure. Therefore, when considered in combination with the results from the CCA, sensitivity occurring at doses relevant for risk assessment was not observed in the d atabase . Thus, data from adult animals are protective of any effects in the young. Additionally, BMD results using cholinesterase inhibition are protective for the effects observed in pups in the DNT study.

TCVP is classified as a Group C possible h uman carcinogen with a linear low

- dose approach for quantification of risk using the oral slope factor (Q1*) of 1.83 x 10

- 3



## .

## Page 14 of 124

Acute Toxicity
In acute lethality studies, TCVP has low acute toxicity by the oral, dermal, and inhalation routes of exposure. It is a slight dermal irritant, a moderate eye irritant, and a dermal sensitizer.

Table 3.1 . Acute Toxicity of Tetrachlorvinphos Technical Guideline No. Study Type MRID No. Results Toxicity Category

870.1100 Acute Oral

– Rat 41222504 LD 50 

### = 1480 mg/kg (M) 465

- 965 mg/kg (F) III

870.1200 Acute Dermal

– Rabbit 41222505 LD 50 

### > 2000 mg/kg III
870.1300 Acute Inhalation

- Rat 00138933 LC50 > 3.61mg/L IV

870.2400 Acute Eye Irritation

- Rabbit 41222506 M oderate III

870.2500 Acute Dermal Irritation

- Rabbit 41222507 S light IV

870.2600 Skin Sensitization

- Guinea Pig 41377902
, 42981001 S ensitizer N/A

870.6100 Acute Delayed Neurotoxicity 41905901 No clinical signs of neurotoxicity observed (NTE not measured) N/A



## Toxicological PoDs Used for Risk Assessment

Incidental Oral, Steady State For the purpose of assessing potential risk associated with incidental oral exposure from steady state durations, OPP selected the POD and endpoint from an oral subchronic toxicity study conducted in adult rats in which RBC cholinesterase inhibition was ob served. This study is appropriate for a childrens assessment since the acute and repeat CCA studies did not demonstrate sensitivity of juvenile pups compared to adults. Therefore, quantitation of incidental oral risks was performed using the female BMDL 1 0 

## value of 8.0 mg/kg/day, based on RBC ChE inhibition and the BMD 10 

## of 10.5 mg/kg. The selected study is protective of all populations since there is no concern for increased quantitative susceptibility in acute and repeated dosing CCA studies.

Inhalati on, Steady State The steady state inhalation POD was selected from a 4

- week inhalation toxicity study (MRID 48803501) in rats, based on an increase in RBC cholinesterase inhibition in both sexes. Females had slightly lower modeled values ( BMDL 10 

## of 0.022 mg/L/day: BMD 10 

## of 0.12 mg/L/day). The duration of this study is considered appropriate for the steady state exposure scenario since steady state occurs within 21 days, as demonstrated for other OPs, and a longer

- term exposure would not be exp ected to res ult in a lower POD. The methods and dosimetry equations described in the Agency’s reference concentration (RfC) guidance are suited for calculating human equivalent concentrations (HECs) based on the inhalation toxicity POD obtained in rats exposed for 6 hr/day for an average of 5.5 days/week. The regional deposited dose ratio (RDDR), which accounts for

## Page 15 of 124

the particulate diameter (mass median aerodynamic diameter [MMAD] and geometric standard deviation [GSD] of aerosols) can be used to estimate the differen t dose fractions deposited along the respiratory tract surface areas. Thus, the RDDR can be used to adjust an observed inhalation particulate exposure of an animal to the predicted inhalation exposure for a human. For the subchronic inhalation toxicity s tudy with TCVP, a RDDR of 2.525 was estimated based on extrarespiratory effects (RBC cholinesterase inhibition) in Sprague Dawley rats (bodyweight = 267g). The MMAD and GSD of 2.57 and 3.785 μm, respectively, at 0.05 mg/L were used to derive the RDDR.

Th e HECs are summarized in Table 3.2 , as well as human equivalent doses (HEDs) calculated for residential and occupational handler scenarios. For residential handler scenarios, a HED was calculated using a breathing rate of 16.7 L/min. For occupational han dler scenarios, HEDs were calculated for breathing rates of 8.3, 16.7, and 29 L/min to account for different occupational activities. The standard interspecies extrapolation uncertainty factor can be reduced from 10X to 3X due to the HEC calculation accou nting for pharmacokinetic (not pharmacodynamic) interspecies differences. The intraspecies uncertainty factor remains at 10X.

.

Table 3.2. Estimated Human Equivalent Concentration (HEC)/Human Equivalent Dose (HED) Population HEC (mg/L) HED (mg/kg/day) Residential Handler 0.05555 1.590 Residential Bystander 0.00992

- Occupational

- 8.3 L/min breathing rate

- 16.7 L/min breathing rate

- 29 L/min breathing rats 0.04166 2.371 4.771 8.285 RDDR = 2.525 (extrarespiratory) based on MMAD±GSD of 2.57±3.785 observed at 0.05 mg/L in Sprague

Dawley rats using 267g default bodyweight (MRID 48803501)

. 

## Dermal, Steady State No quantification of dermal non

- cancer risk is required for TCVP. There were (1) no treatment related effects (no clinical signs) at doses up to and including the limit dose in the dermal toxicity study; (2) both RBC and brain cholinesterase activity were assessed in the dermal study and neither compartment was affected at the limit dose; (3) there is no concern for quantitative susceptibility for juvenile or gestational lifestages based on results of the developmental, reproductive, or CCA toxicity studies; and (4) the effects observed in pups from the DNT were 10

- fold above the 10% inhibition level with a dermal equivalent dose necessary to pr oduce an eff ect well above the limit dose. TCVP is classified as a Group C possible human carcinogen by the Agency with a linear low

dose approach for quantification of risk using the oral slope factor (Q1*) of 1.83 x 10

- 3 (mg/kg/day)

- 1



## . Uncertainty Fact ors
A total uncertainty factor of 1000X is appropriate for the assessment of dermal and oral routes of exposures [10X for interspecies extrapolation, 10X for intraspecies variation and a 10X Food

## Page 16 of 124

Quality Protection Act (FQPA) Safety Factor (SF)/database uncertainty factor (UFDB)]. The FQPA SF, which is specific to residential exposure scenarios, has been retained for infants, children, youths, and women of childbearing age for all exposure scenarios due to uncertainty in the human dose

- response relations hip for neurodevelopmental effects 9 

## . For the inhalation route of exposure, a total SF of 300X is appropriate (3X for interspecies extrapolation, 10X for intraspecies variation, and 10X Food Quality Protection Act (FQPA) Safety Factor (SF)/da tabase uncertainty factor ). The interspecies extrapolation is reduced from 10X to 3X because the reference concentration (RfC) methodology for inhalation is used to determine an HEC and takes into consideration the pharmacokinetic differences between animals and humans. The database uncertainty factor was also retained for the protection of occupational workers (dermal and inhalation exposures) who may be pregnant due to uncertainty in the human dose

- response relationship for neurodevelopmental effects

.
Absor ption
Despite the determination of the lack of dermal hazard for TCVP, dermal exposures from TCVP must be quantified for purpose of cancer and incidental oral (hand

- to

- mouth) risk assessment. Because an oral study was selected for dermal exposure assessment, a dermal absorption factor (DAF) of 9. 6% was used in the route

- to

- route extrapolation. The DAF is based on the results of a dermal penetration study in rats. Since the inhalation PoD was based on a route

- specific toxicity study, no absorption factor was necessary to estimate exposure.

Body Weight
For adults, when an endpoint is not sex

- specific (i.e., the endpoints are based on developmental or fetal effects) a body weight of 80 kg is typically used in risk assessment; however, in this case, a female

- specific body weight of 69 kg was used. While the endpoint of concern, RBC AChE inhibition, is not sex

- specific, the female body weight was used for pregnant women due to uncertainty in the human dose

- response relationship for neurodevelopmental effects.
A body weight of 11 kg was assumed for children 1 to < 2 years old.

Table 3. 3

. Summary of Toxicological Doses and Endpoints for TCVP for Use in Occupational and Residential Human Health Risk Assessments

Exposure/ Scenario Point of

Departure Uncertainty

Factors Level of

Concern for Risk Assessment Study and Toxicological Effects

Incidental Oral ( steady state ) BMDL 10 

### = 8.0

mg/kg/day UF A 

### = 10 X

UF H 

### =10 X FQPA SF = 10X Residential

LOC is an MOE = 100 0 Subchronic Oral Toxicity Study (MRID

43371201)

– Ra t

BMD 10 

### = 10.49 mg/kg/day, based on female RBC ChE inhibition

9 

### For more information, please reference Sections 4.4 and 4.5 of the Tetrachlorvinphos Human Health Draft Risk Assessment for Regist ration Review. D. Drew. D411095. 12/21/2015.

## Page 17 of 124

Table 3. 3

. Summary of Toxicological Doses and Endpoints for TCVP for Use in Occupational and Residential Human Health Risk Assessments

Exposure/ Scenario Point of

Departure Uncertainty

Factors Level of

Concern for Risk Assessment Study and Toxicological Effects

Dermal (steady state) No potential hazard via the dermal route, based on the lack of treatment

- related effects, including

the lack of RBC and brain cholinesterase inhibition following repeat dermal exposure of rats at dose levels up to 1000 mg/kg/day and no concern for quantitative susceptibility.

Inhalation ( steady state ) Occupational

BMDL 10 

### =0.022 mg/L/day (males) UF A 

### = 3x

UF H 

### =10x UF DB 

### = 10x Occupational

LOC for MOE

= 3 00 Subchronic Inhalation Toxicity Study

(MRID 48803501)

- Ra t

BMD 10 

### = 0.12 mg/L/day, based on RBC ChE inhibition in both sexes Residential

BMDL 10 

### =0.022 mg/L/day (males) UF A 

### = 3x

UF H 

### =10x FQPA SF = 10X Residential

LOC for MOE = 300 Subchronic Inhalation Toxicity Study

(MRID 48803501 )

– Ra t

BMD 10 

### = 0.12 mg/L/day, based on RBC ChE inhibition in both sexes

Cancer (oral, dermal, inhalation) Classification: A possible human (Group C) carcinogen

. Q 1 

### * = 1.83 x 10

- 3



### (mg/kg/day)

- 1

1 Explanation of Abbreviations: Point of Departure (PoD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (inters pecies). UF H = potential variation in sensitivity among membe rs of the human population (int r a species ). UF DB = database uncertainty factor due to the potential for neuro developmental effects. FQPA SF = potential for neuro developmental effects. MOE = margin of exposure. LOC = level of concern. N/A = not applicable.



## 4 .0 Use Profile
TCVP is used as a direct animal treatment to livestock (i.e., cattle, horses, poultry and swine) and their premises, in kennels, outdoors as a perimeter treatment, and as a flea treatment on cats and dogs. There are 42 end

- use product labels currently registered with TCVP as the ai . The TCVP livestock and perimeter treatment uses are formulated as follows: dusts (D), emulsifiable concentrate s (EC), feed through (solid and liquid food additives), feed blocks, and wettable powders (WP). TCVP can be applied by a variety of means/equipment types including : backrubber/facerubber; backpack; cup; groundboom; handheld fogger; manually

- pressurized ha ndwand; mechanically

- pressurized handwand; open pour (dust and liquid formulations); paint (airless sprayer or brush/roller); pet collar; plunger; rotary duster; shaker can; spoon; stationary fogger; and trigger spray.

The PPE required for occupational us e of TCVP varies by formulation type . For feed through (solid and liquid food additives) and feed blocks, occupational handlers are required to wear baseline clothing (i.e., long sleeved shirt, long pants, shoes and socks) and gloves. For all other

## Page 18 of 124

end

- u se labels with livestock and outdoor perimeter uses, required PPE can vary dependent on the application type or equipment and can range from baseline clothing and gloves, to the addition of coveralls, or respiratory protection [(i.e

. , protection factor 5 ( PF5) or protection factor 10 (PF10)].
A summary of all registered TCVP labels and use directio ns are presented in Appendix C of this document. Table C .1 present s the livestock uses and Table C .2 presents pet uses.

5.0 Residential Exposure and Risk Estimates
Residential exposures (handler and post

- application) are anticipated from the use of TCVP pet products for dogs and cats including collars, dusts/powders, and pump/trigger sprays

. Exposures are expected for adults who apply TCVP products to th eir pets and from post

- application exposures for adults and children who may contact previously treated pets.

A risk assessment of a ll currently registered TCVP pet products w as recently completed (D420283; 11/2014). The interpretation of the risk outcomes of this assessment have been updated since the incidental oral and inhalation LOCs have increase d 10 fold due to uncertainty in the human dose

- response relationship for neurodevelopmental effects and, therefore, residential exposure scenarios whic h were previously not of concern to the Agency may now be of concern . Other updates since the 2014 assessment include the following: the determination of no dermal hazard from TCVP; and the use of a female

- specific body weight, 69 kg, for assessment of a dult exposures instead of the average adult body weight of 80 kg

. In following EPA’s 2014 residential assessment, NRDC filed the August 5, 2015 Opening Brief in NRDC v. EPA , Case No. 15

- 70025 (9 th 

## Cir.) in the TCVP litigation for the 9 th 

## Circuit. Several arguments were presented which pertain to the safety factor, exposure data and assumptions used by EPA to complete the 2014 assessment. This document takes into account, where appropriate, many of the arguments presented in the Opening Brief

. The EPA point

- by

- point response to NRDC comments can be found in D430589. 10



## Exposures are expected for adults who apply TCVP products to their pets and from post

application exposures to adults and children who may contact previously treated pets

. Residential TCVP handler and post

- application exposures are anticipated to be short

- (1 to 30 days) to intermediate

- term (1 to 6 months). However, because of the steady state AChE inhibition exhibited by the OPs, steady state exposures (21 days and lon ger) were assessed and presented for residential exposures to TCVP pet products.

5.1 Residential Handler Exposures
HED uses the term “handlers” to describe those individuals who are involved in the pesticide application process. HED believes that there are distinct tasks related to applications and that exposures can vary depending on the specifics of each task. Residential handlers are assumed to

10 

### W. Britton, Tetrachlorvinphos (TCVP): Responses to Arguments Presented in the Natural Resources Defense Council, Inc.’s (NRDC) Aug. 5, 2015 Opening Brief in NRDC v. EPA , Case No. 15

- 70025 (9 th 

### Cir.)

. 12/21/15, D430589.

## Page 19 of 124

complete all elements of an application without use of any protective equipment.

Residential handler expos ures to TCVP pet products may occur via the dermal or inhalation routes while the product is placed on a cat or dog. Both steady state non

- cancer and cancer residential handler exposure assessments were performed for adult homeowners applying TCVP pet collars, dusts/powders, and pump/trigger sprays products to cats and dogs. Since there is no

non

- cancer dermal hazard for TCVP, the steady state (non

- cancer) handler assessment includes only inhalation exposures. For the cancer assessment, both dermal and inhalation exposures are assessed. The exposure data and assumptions that underlie the residential handler non

- cancer risk estimates can be referenc ed in the 11/2014 assessment and the 2012 Residential SOPs

. The algorithms used to estimate non

- cancer exposure and dose for residential han dlers can be found in Appendix D and/or the 2012 Residential SOPs. 11



## The 2014 residential handler assessment was co nducted based on the assumption that TCVP pet collars are a liquid product and, therefore, used only the liquid

- specific UE. However, because there is uncertainty whether the TCVP pet collars are liquid and/or dust formulated products, residential handler steady state inhalation exposures for TCVP pet collar application were assessed with use of both liquid

- and dust

- specific UE data. When assuming the TCVP pet collars are a liquid formulation, the liquid

- specific unit exposure (UE) values (i.e., surrogat e data from spot

- on applicator study) from the 2012 Residential SOPs were used. When assuming the pet collars are a solid formulation, HED used the best available data, a TCVP dust/powder applicator exposure study (MRID 45519601). The NRDC argument relating to the TCVP pet collar product formulation and the associated EPA response can be found in D430589, EPA r esponse #4. 12



## Summary of Residential Handler Non

- Cancer Exposure and Risk Estimates

Dust/Powder and Pump/Trigger Spray: All residential ha ndler (adults) non

- cancer (steady state) inhalation risks estimated for the TCVP pet dust/powder and pump/trigger spray formulations are not of concern (i.e., all MOEs are > 300; LOC=300).

Pet Collars: No handler risks of concern were identified with the use of either liquid

- or dust

specific UE data ( i.e., all MOEs are > 300; LOC=300)

. A summary of residential handler exposures and risks is presented in Appendix E

. Residential Handler Cancer Exposure and Risk Estimate Equations

11 

### http://www2.epa.gov/pesticide

- science

- and

- assessing

- pesticide

- risks/standard

- operating

- procedures

- r esidential

pesticide
12 

### W. Britton, Tetrachlorvinphos (TCVP): Responses to Arguments Presented in the Natural Resources Defense Council, Inc.’s (NRDC) Aug. 5, 2015 Opening Brief in NRDC v. EPA , Case No. 15

- 70025 (9 th 

### Cir.). 12/21/15, D430589.

## Page 20 of 124

Cancer risk estimates were calculated using a linear low

- dose extrapolation approach in which a Lifetime Average Daily Dose (LADD) is first calculated and then compared with a Q 1 

## * that has been calculated for TCVP based on dose response data in the appropriate toxicol ogy study (Q 1 

## * = 1.83 x 10

- 3 

## (mg/kg/day)

- 1 

## ). Absorbed average daily dose (ADD) levels were used as the basis for calculating the LADD values. Dermal and inhalation ADD values were first added together to obtain combined ADD values. LADD values were then calculated and compared to the Q 1 

## * to obtain cancer risk estimates.

The exposure d ata and assumptions that underlie the residential handler cancer risk estimates can be referenced in the 11/2014 assessment and the 2012 Residential SOPs

. The algorithms used to estimate the LADD and cancer risk for residential handlers can be found in Appendix D

. Summary of Residential Handler Cancer Exposure and Risk Estimates

Dust/Powder and Pump/Trigger Spray: Residential handler cancer risks (inhalation and dermal combined) estimated for TCVP dusts/powders range from 10

- 8 

## to 10

- 7 

## , and for pump/trigger sprays range from 10

- 9 

## to 10

- 8



## .
Pet Collars: For the TCVP pet collars, residential handler cancer risks were estimated with use of liquid

- and dust

- specific UE data as was done for the non

- cancer assessment. With use of the liquid

- specific UE data, residential handler cancer risks estimated for the TCVP pet collar are all 10

- 8 

## , and with use of the dust

- spec ific UE data cancer risks are all 10

- 7



## . A summary of residential handler cancer exposures and risks is presented in Appendix F

.

5. 2 Residential Post

- application Exposure/Risk Estimates
There is the potential for post

- application exposure for individuals exposed as a result of contacting a cat/dog previously treated with TCVP pet products (dusts/powders, pump/trigger sprays, pet collars). The quantitative exposure/risk assessment for residential post

- application exposures is based on the follo wing scenarios:

1) Post

- application dermal (adults and children 1 to < 2 years old) exposure from contacting cats and dogs treated with TCVP; and 2) Post

- application incidental oral (hand

- to

- mouth) exposure (children 1 to < 2 years olds only) from co ntacting cats and dogs treated with TCVP.

A quantitative residential post

- application inhalation exposure assessment was not performed as inhalation exposure is expected to be negligible from applications to pets. However, an inhalation exposure assessment was performed for pet handlers (i.e., ve terinarians, veterinary assistants, and groomers ) and this exposure scenario should be considered protective of any potential low

- level post

- application inhalation exposure that could result from these types of applications

.

## Page 21 of 124

The lifestages selected for ea ch post

- application scenario (i.e., adults and children 1 to < 2 years old) are based on an ana lysis provided as an Appendix and the 2012 Residential SOPs 13 

## . While not the only lifestage potentially exposed for these post

- application scenarios, the lifesta ge that is included in the quantitative assessment is health protective for the exposures and risk estimates for any other potentially exposed lifestage.

Residential Non

- Cancer Post

- Application Exposure Data and Assumptions A series of assumptions and exposure factors served as the basis for completing the residential cancer post

- application risk assessment

. 

## The exposure data and assumptions that underlie the residential non

- cancer post

- application risk estimates can be referenced in the 11/2014

assess ment and the 2012 Residential SOPs.

Several inputs and assumptions that underlie the residential post

- application risk assessment of TCVP pet products are addressed by EPA in the responses to NRDC’s August 5, 2015 Opening Brief 14 

## , including: the default transferable residue of 2% ; use of the Davis study; TCVP pet collar product formulation type; daily exposure time spent in contact with TCVP treated pets; indirect hand

- to

- mouth activity; and the application of transferable residue data in EPA’s risk asse ssment algorithms.

Residue Transfer Assumptions : Surrogate and chemical

- specific residue transfer studies were used for assessment of post

- application exposures from registered TCVP pet products. Dust/Powder and Pump/Trigger Spray: A TCVP powder and pump spray study ( MRID 45485501) was used. A summary and discussion of the use of these data was included in the 2014 residential risk assessment. As described in the 2014 residential risk assessment, the TCVP powder and pump spray post

- a pplication exposure study was not conducted in a manner reflective of current standards that require a defined stroking procedure and greater number of petting simulations. In order to account for th is difference , the Agency used the maximum observed perc ent residue transfer on the day of product application (Day 0) for both formulations for ex posure and risk quantification. Typically, the Agency assesses post

- application risk with use of the mean percent residue transfer measured on Day 0; the use of the maximum value results in a more health protective risk assessment. Even though the post

- application exposure study methods have evolved, the TCVP study employed a rigorous collection method and is not anticipated to underestimate exposure.

The 2012 Resid ential SOPs: Treated Pets recommends assessment of post

- application exposures using day of application (i.e., Day 0) residue transfer

-- defined as fraction application rate (F AR 

## ) in the 2012 SOPs. Day of application (Day 0) percent residue transfer value s used in the 2014 residential risk assessment for exposure/risk quantification of dusts/powders and pump/triggers

13 

### Available : http://www2.epa.gov/pesticide

- science

- and

- assessing

- pesticide

- risks/standard

- operating

- procedures

residential

- pesticide
14 

### W. Britton, Tetrachlorvinphos (TCVP): Responses to Arguments Presented in the Natural Resources Defense Council, Inc.’s (NRDC) Aug. 5, 2015 Opening Brief in NRDC v. EPA , Case No. 15

- 70025 (9 th 

### Cir.). 12/21/15, D430589.

.

## Page 22 of 124

sprays are as follows: dusts/pow ders, 0.048% (maximum observed) and pump sprays, 0.81% (maximum observed).

Pet Collars: For pet collars
, data from two residue transfer studies were used for estimating exposures to the TCVP collar uses: an amitraz pet collar residue transfer study (MRID 49468801) and a literature study using TCVP pet collars (Davis, M., 2008). Subsequent to the completion of the 2014 residential risk assessment, an amitraz pet collar residue transfer study was submitted to EPA. A propoxur pet collar was used for assessment of post

- application risks from TCVP pet collars in the 2014 residential risk assessme nt. Based on the review of the amitraz pet collar study 15 

## , it was determined that the mean Day 0 residue transfer resulting from the amitraz pet collar , 0.14%, exceeds the mean residue transfer measured on Day 0 from the pro poxur pet collar, 0.072%. As a result, HED has updated the risk estimates for exp osures resulting from contact with a TCVP pet collar

- treated pet. The NRDC argument relating to the use of pet collar residue transfer data and the associated EPA response can be found in D430589 , EPA resp onse #2

. 16



## As described in the 2014 residential risk assessment, for purpose of quantification of estimated TCVP post

- application cancer exposures/risks, HED has used the mean percent residue transfer of all days sampled to best represent the assumption of 180 days exposure per year . The mean residue transfer of all days sampled in the amitraz pet collar exposure study, 0.047% (over 28 days), also exceeds the mean residue transfer of all days sampled in the propoxur study, 0.013% (over 28 days). For the post

- application cancer asse ssment, HED assumes that 0.047% residue transfer may occur over an adult exposure period of 180 days per year.
The Davis study was used in addition to the amitraz study to assess non

- cancer and cancer post

application risks following contact with TCVP p et collar treated pets. The study measured exposures by means of petting/rubbing TCVP pet collar treated dogs with a cotton gloved hand, t

- shirts worn by children, urinary biomonitoring of adults and children exposed to the treated dogs, as well as monito ring of plasma ChE levels of the treated dogs. The NRDC argument relating to the use of the Davis study and the associated EPA response can be found in D430589, EPA response #3.
A summary of both the amitraz pet collar residue transfer is presented below , as well as a summary of the Davis study and a description of how these data have been used for risk quantitation

. Table 5.3 below presents the summary of amitraz post

- application percent residue transfer.

15 

### A. Gavelek. Amitraz: Data Evaluation Record for the Study “Determination of Transferable Residues of Amitraz from the Hair of Do gs Following the Application of the Preventic® Collar. D424229. 9/30/2015.
16 

### W. Britton, Tetrachlorvinphos (TCVP): Responses to Arguments Presented in the Natural Resources Defense Council, Inc.’s (NRDC) Aug. 5, 2015 Opening Brief in NRDC v. EPA , Case No. 15

- 70025 (9 th 

### Cir.). 12/21/15, D430589.

## Page 23 of 124

MRID 49468801: Determination of Transferable Residues of Amitraz from the Hair of Dogs Following the Application of the Preventic® Collar.
The purpose of the study was to measure the transferability of the test substance from the hair of a dog wearing an amitraz impregnated collar. Eac h collar contained 9% amitraz (wt/wt). The collars are typically applied to dogs by securing the collar around the dog’s neck and cutting off any excess collar length.
A total of 15 dogs were used in the study (all test dogs and no control dogs). Amit raz residues found on cotton gloves were measured after 20 petting simulations to treated dogs. Each simulation consisted of three strokes (60 strokes total) conducted using a mannequin hand fitted with cotton gloves over top of a nitrile glove. For the pre

- application sampling interval, three cotton gloves were placed over the nitrile glove and for the post

- application simulations, five cotton gloves covered the nitrile glove. After the petting simulations were complete, the gloves were removed individua lly from the mannequin hand, and the nitrile gloves were discarded. Amitraz residues were extracted from the cotton gloves. Samples were collected from each dog at the following intervals: prior to treatment, at 4 hours after treatment and at 1, 2, 4, 7, 14, and 28 days after treatment.
Fortifications were prepared at the Day 14 and on the Day 28 sampling intervals. Field fortification samples were prepared by fortifying gloves at levels which approximated residue transfer rates of 0.001% (10 μg/glove) , 0.1% (1,000 μg/glove), and 1.0% (10,000 μg/glove) of the applied dose to the dog. All individual recoveries were within the acceptable range of 70 to 120%. When residues were reported as less than the LOD (0.005 μg/glove) or LOQ (0.05 μg/glove), these re sults are reported as 1⁄2 LOD or 1⁄2 LOQ, as appropriate.

Average total 5 glove residue for each sampling interval showed that maximum residues occurred four hours after application of the collars at 1,954 μg/gloves (0.14% of applied dose and 0.395 μg/cm2 su rface area of dog). Residues declined steadily to 306 μg/gloves (0.02% of applied dose and 0.06 μg/cm2 surface area of dog) on Day 4 after application before rising slightly on Day 7. Residues then declined to 128 μg/gloves (0.01% of applied dose and 0.02 6 μg/cm2 surface area of dog) by Day 28 after application.

Table 5. 2

. Summary of Amitraz Residue Transferred from Cotton Gloves Following 20 Petting Simulations to Treated Dogs Total Residue % of applied dose transferred a



### Interval μg/gloves μg/cm2 body surface area of dog

Average Standard

Deviation Average Standard Deviation Average Standard Deviation

4 hours 1954 815 0.395 0.163 0.144 0.057 1 day 902 470 0.178 0.082 0.066 0.031 2 days 443 223 0.088 0.039 0.032 0.015 4 days 306 188 0.060 0.034 0.022 0.013 7 days 434 277 0.085 0.050 0.032 0.019

## Page 24 of 124

Table 5. 2

. Summary of Amitraz Residue Transferred from Cotton Gloves Following 20 Petting Simulations to Treated Dogs Total Residue % of applied dose transferred a



### Interval μg/gloves μg/cm2 body surface area of dog

Average Standard

Deviation Average Standard Deviation Average Standard Deviation
14 days 283 173 0.056 0.032 0.021 0.012 28 days 128 85.7 0.026 0.017 0.009 0.007
Note : Totals represe nt sum of five cotton gloves.

a % of applied dose transferred = total μg ai in all gloves of one dog / μg ai applied to the dog

.



## Davis Study

- Davis, M., et al. Assessing Intermittent Pesticide Exposure from Flea Control Collars Containing the Organophosphorus Insecticide Tetrachlorvinphos. Journal of Exposure Science and Environmental Epide miology. (2008) 18, 564

- 570)

. The journal article, Davis et al., 2008, was conducted with the purpose of investigating the exposures to TCVP that could occur in children and adults from the use of a TCVP

- containing collar on pet dogs. A single product was tested, Hartz Mountain Ultimate Flea Collar, which is composed of 14.55% TCVP. Two separate studies were conducted with the test product as a part of the journal article. Both were conducted in Oktibbeha County, Mississippi, with volunteer households ha ving pet dogs. Study 1: The first study was longer, about 4 months (112 days), and evaluated to determine the time course of TCVP residue peak and dissipation from transfer to white cotton gloves used to rub, or pet, the dogs’ fur. Twenty three dogs of different breeds and weights were treated with the TCVP flea collar in study 1. Dogs were petted by volunteers continuously for a 5 minute period with use of cotton glove in following with a defined rubbing protocol. Although not described in the article , it was deduced that the rubbing protocol was repeated for each dog/volunteer to result in a measure of transferable residue 1) from the fur of the neck (rubbing over the collar) 2) from the fur of the neck (with the collar removed) and 3) along the back in the tail region. Study 1 also analyzed plasma cholinesterase (ChE) activity from blood samples taken from each dog at the same time as the rubbing samples. Pre

- collar and post

- collar application samples were collected for the evaluation of residue tra nsfer to gloves and the dogs blood ChE activity. Significant increases in transferable TCVP residues were observed from cotton gloves used to pet dogs compare to pretreatment concentrations. In study 1, transferable residues from all three sampling loc ations decreased (86% decline) throughout the 112 days following a peak at day 7 post

- collar application, 24,000 ± 4,000 μ g/glove over the collar. Similar trends were also observed in detectable residues around the neck without the collar in place and in the tail region where there were 94% and 71% decreases, respectively. Mean glove residues for all sampling times were 14,300 μ g/glove over the collar, 4,300 μ g/glove on the neck with the collar removed, and 130 μ g/glove in the tail region. No significant changes in dog plasma ChE

## Page 25 of 124

Study 2: The second, subsequent study was conducted on the basis that results from study 1 indicated that TCVP residues peaked and then suddenly dropped within 3 weeks of collar placement. Therefore, the second study was conduct ed over a 3 week (21 days) period, and included human biomonitoring of the TCVP metabolite, 2,4,5

- trichloromandelic acid (TCMA), in urine of adults and children. The second study also measured TCVP residues as transferred from treated dogs to cotton t

- shi rts worn by children, as well as those transferred to cotton gloves from petting the dogs’ fur. Pre

- and post

- collar samples were collected for the residue collection by glove, t

- shirt, and the biomonitoring phase of study 2. In study 2, TCVP residues ob tained over the collar and around the neck without the collar in place decreased (30% decline) from 5 to 12 days post

- collar application, while residues obtained from the tail region remained fairly constant (81 μ g/glove at 5 days and 82 μ g/glove at 12 da ys). The peak transferable residues collected over the collar at 5 days post

- collar application were of a similar magnitude to those observed in study 1. Mean residues (for all gloves analyzed) post

collar application were 19,000 μ g/glove over the collar , 8,000 μ g/glove on the neck with the collar removed, and 80 μ g/glove in the tail region. The average amount of TCVP residues detected on children’s t

- shirts on sampling days 7

- 11 post

- collar application was 1.8 ± 0.8 μ g/shirt, with no significant differ ences among the sampling days. Transferable residues were significantly greater than the mean pre

- treatment residue of 0.03 ± 0.006 μ g/shirt. Urine samples collected from children generally contained more urinary TCMA than that from the adults with sign ificant differences between the ages occurring on only 1 of the 5 sampling days (day 11). No significant differences in urinary TCMA concentrations were observed among the adults or among the children throughout the study. The ranges of TCMA concentratio ns were large; 1.4

- 582 ng/ml urine for adults, and 2.1

- 1,558 ng/ml urine in children. The urinary TCMA concentrations were all adjusted for creatinine content; however, there were no differences in outcomes and, as a result, reported values were unadj usted. No significant correlations were identified among t

- shirt TCVP residues, the amount of time spent with treated dogs, and urinary TCMA concentrations.

Use of the Davis Study: For the purpose of non

- cancer and cancer post

- application risk assessment, only the results of the pet fur transferable residue collection (petting/rubbing with a gloved cotton hand) were used. This collection method is the Agency standard for determining the residues that can transfer from a treated animal to an exposed individual, referred to as the fraction of application rate (F AR 

## ) transferred. The petting/rubbing method used in the study is not conducted based entirely upon the current Agency guidanc e for studies of this type; however, the method is relevant for the time at which it was conducted, and has been deemed adequate for risk quantitation. Transferable residue petting/rubbing samples were collected 1) from the fur of the neck (rubbing over t he collar) 2) from the fur of the neck (with the collar removed) and 3) along the back in the tail region. The F AR 

## value was determined by dividing the sum of the residues measured from the fur over the collar and from the back in the tail region by the a mount of active ingredient in the pet collar (as reported in the Davis study), 4,800 mg . The transferable residue measures from the fur of the neck with the collar removed was not summed with the

## Page 26 of 124

other measures since the collection or residues under the c ollar is inconsistent with the current guidance for pet fur transfer residue studies which requires petting to occur over the pet collar assuming that the pet collar is secured in place as directed by product labeling.

The F AR 

## used for non

- cancer post

- a pplication risk assessment , 0.0040 (0.4%) is based on the mean residues (12 days) reported from study 2 [where (19 mg + 0.08 mg)/ 4,800 mg = 0.0040]. These data result in a more stringent risk assessment than with use of the surrogate (amitraz) pet collar residue transfer data. The percent residue transfer resulting from the Davis study, 0.4%, is greater than that estimated with use of the amitraz pet collar study, 0.14% (day 0

- highest mean day sampled) and, as a result, a greater potential for post

- app lication risks. For the assessment of cancer post

- application risks, longer

- term residue transfer values were used to best represent the assumption of 180 days/year exposure for cancer assessment. The percent residue transfer resulting from use of the Da vis study (study 1

- 112 day mean), 0.3%, is greater than that estimated with use of the amitraz pet collar study (28 day mean), 0.047%.

As described in 

## D430589 (response #3 17 

## ), until such time the Davis study has undergone HSRB review, post

- application r isk estimates for exposure to pet collar treated pets are considered to be preliminary. Therefore, non

- cancer and cancer risk estimates have been presented with use of both the amitraz residue transfer study and the Davis study.

Residential Non

- Cancer Post

- application Exposure and Risk Equations
The algorithms used to estimate non

- cancer exposure and dose for residential post

- applic ation can be found in Appendix D and the 2012 Residential SOPs.

Summary of Residential Post

- Application Non

- Cancer Expo sure and Risk Estimates

Dust/Powder and Pump/Trigger Spray: For children (child 1 to < 2 years old), residential post

application non

- cancer incidental oral (hand

- to

- mouth) exposures to pets treated with TCVP pump/trigger sprays are not of concern (i.e., MOEs are > 1,000; LOC=1000). However, child incidental oral (hand

- to

- mouth) exposures to pets treated with TCVP dust/powder products are estimated to be of concern for 14 of 17 total exposure scenarios assessed (i.e., MOEs are < 1,000; LOC=1000).

Pet Collars: Liquid formulation/Amitraz study assumption: Post

- application child non

- cancer incidental oral risk estimates are not of concern (i.e., MOEs are > 1,000; LOC=1000).

Liquid formulation/Davis study assumption: One of the 23 scenarios assessed (EPA Reg. No. 2596

- 139; exposures to a small sized dog) for post

- application child non

- cancer incidental oral risk is of concern (MOE = 650; LOC=1000).

17 

### W. Britton, Tetrachlorvinphos (TCVP): Responses to Arguments Presented in the Natural Resources Defense Council, Inc.’s (NRDC) Aug. 5, 2015 Opening Brief in NRDC v. EPA , Case No. 15

- 70025 (9 th 

### Cir.). 12/21/ 15, D430589.

## Page 27 of 124

Dust formulation/Amitraz study assumption: Post

- application child non

- cancer incidental oral risk estimates are of concern for all of the TCVP pet collar ex posure scenarios assessed (i.e., MOEs are < 1,000; LOC=1000).

Dust formulation/Davis study assumption: Quantitative assessments were not performed assuming collars are dust formulations and using the Davis study since the mean residue transfer measured in the Davis study was greater than that in the amitraz study; therefore, post

application exposures from TCVP pet collars would be greater, and MOEs lower, when using the Davis study than those resulting from using the amitraz study (which are of concern for children).
A summary of residential post

- application exposures and risks from TCVP pet products is presented in Appendix G. The combined MOE approach was used because the dermal and incidental oral routes of exposure have the same toxic effect and LOC.

Residential Cancer Post

- Application Exposure Data and Assumptions A series of assumptions and exposure factors served as the basis for completing the residential

cancer post

- application risk assessment. All exposure data and assumptions that underli e the residential post

- application cancer risk estimates can be referenced in the 11/2014 assessment. Note: For purpose of quantification of estimated TCVP post

- application cancer risks, HED used average percent residue transfer data for all days sampled from chemical

- specific exposure data for all pet formulation assessed.

Residential Cancer Post

- application Exposure and Risk Estimate Equations

As was done for residential handlers, cancer post

- application risk estimates for adults were calculated using a linear low

- dose extrapolation approach in which a LADD is first calculated and then compared with a Q 1 

## * that has been calculated for TCVP based on dose response data in the appropriate toxicology study (Q 1 

## * = 1.83 x 10

- 3 

## (mg/kg/day)

- 1 

## ). The algorithms used to estimate the LADD and cancer risk for residential post

- application exp osure can be found in Appendix D

. It should be noted that in the past, cancer risk assessments have assumed that children are no more sensitive than adults to carcinogens (i.e ., no adjustment was made to children's exposure estimates in calculating a cumulative lifetime exposure). More recently, the Agency's "Guidelines for Carcinogen Risk Assessment" (USEPA, 2005) and “Supplemental Guidance for Assessing Susceptibility from E arly

- Life Exposure to Carcinogens” (USEPA, 2005) proposed age

- dependent adjustment factors to be applied to children's exposure. These age

- dependent factors are applied only to carcinogens shown to have a mutagenic mode of action. In general, most carcin ogenic pesticides have not been shown to act through a mutagenic mode of action, and thus separate assessment of children and adults is not warranted. Any pesticide found to be a carcinogen acting through a mutagenic mode of action should be dealt with on a case by case basis, and such an assessment should follow the Agency’s 2005 guidance. The mutagenicity database for TCVP suggests that this chemical is not mutagenic in both the gene mutation assay and primary rat hepatocyte unscheduled DNA synthesis as say and, therefore, only adult cancer risk estimates have been estimated.

## Page 28 of 124

Summary of Residential Post

- application Cancer Exposure and Risk Estimates

Dust/Powder and Pump/Trigger Spray: Residential post

- application cancer (adult only) risks estimated for TCVP pump/trigger sprays range from 10

- 7 

## to 10

- 6 

## and, for TCVP dust/powder products estimated cancer risks are 10

- 7



## . Pet Collars: Liquid formulation/Amitraz study assumption: Estimated adult post

- application cancer risks range from 10

- 7 

## to 10

- 6



## . Liquid formulation/Davis study assumption: Estimated adult post

- application cancer risks range from 10

- 6 

## to 10

- 5



## . Dust formulation/Amitraz study assumption: All estimated ad ult post

- application cancer risks are estimated to be 10

- 5



## . Dust formulation/Davis study assumption: A quantitative post

- application cancer assessment was not performed using the Davis study and assuming the collars are dust formulations since the mea n residue transfer measured in the Davis study was greater than that in the amitraz study. Cancer risk estimates would be greater using (increased risk) the Davis study than when using the amitraz study. Adult residential post

- application dermal cancer risk estimates are presented in Appendix H.

5. 3 Residential Risk Estimates for Use in Aggregate Assessment

All residential non

- cancer and cancer residential han dler and post

- application risks assessed h erein have been considered for the aggregate assessment ( D. Drew. D411095 ; Section s 6.1 and 6.2 )

. 18



## 5.4 Spray Drift
A quantitative spray drift assessment was not conducted because the use of TCVP for direct animal treatment to livestock and their premises, in kennels, outdoors as a perimeter treatment, and as a flea treatment on cats and dogs are either 1) not applied via aircraft, groundboom, or airblast equipment or 2) for applications to poultry bui ldings with groundboom equipment, the use is indoors and not anticipated to be a significant source of spray drift.

5.5 Residential Bystander Post

- Application Inhalation Exposure
A quantitative residential post

- application inhalation exposure assessment was not performed as inhalation exposure is expected to be negligible from applications to pets . However, an inhalation exposure assessment wa s performed for handlers (i.e., veterinarians, veterinary

18 

### D. Drew. Tetrachlorvinphos Human Health Draft Risk Assessment for Registration Review. D411095. 12/21/2015.

## Page 29 of 124

assistants, and groomers ) and this exposure scenario s hould be considered protective of any potential low

- level post

- application inhalation exposure that could result from these types of applications.

6.0 Occupational Exposure and Risk Estimates

6.1 Occupational Handler Exposure/Risk Estimates
HED uses the term handlers to describe those individuals who are involved in the pesticide application process. HED believes that there are distinct job functions or tasks related to applications and exposures can vary depending on the specifics of each t ask. Job requirements (amount of chemical used in each application), the kinds of equipment used, the target being treated, and the level of protection used by a handler can cause exposure levels to differ in a manner specific to each application event.
Based on the anticipated use patterns and current labeling, types of equipment and techniques that can potentially be used, occupational handler exposure is expected from the proposed uses. The quantitative exposure/risk assessment developed for occupatio nal handlers is based on the following scenarios:

Mixer/Loaders:
(1a) Liquid: Groundboom Applications (1c) Liquid: Paint Applications (2a) Wettable Powder: Groundboom Applications (2b) Wettable Powder: Handheld Fogger Applications (2c) Wettable Powder: Stationary Fogger Applications (2d) Wettable Powder: Paint Applications (3a) Dust: Paint Applications
Applicators:
(4) Groundboom Applications (5) Open Pour Liquid Additive for Feed Through ( 6 a ) RTU Pet Collar

- Liquid Formulation (6b) RTU Pet Collar

- Dust Formulation ( 7 ) RTU Dust/Powder

– Pets ( 8 ) RTU Pump/Trigger Sprays

- Pets
Mixer/Loader/Applicators:

(9 a) Liquid: Backpack Sprayer (9 b) Liquid: Manually

- Pressurized Handwand (9 c) Liquid: Mechanically

- Pressurized Handgun (9 d) Liquid: Backrubber or Facerubber (1 0 a) Wettable Powder: Backpack Sprayer

## Page 30 of 124

(1 0 b) Wettable Powder: Manually

- Pressurized Handwand (1 0 c) Wettable Powder: Mechanically

- Pressurized Handgun (1 0 d) Wettable Powder: Handheld Fogger (1 0 e) Wettable Powder: Stationary Fogger (1 0 f) Wettable Powder: Rotary Duster (1 0 g) Wettable Powder: Plunger Duster (1 1 a) Dust: Self

- Treating Dust Bag (1 1 b) Dust: Shaker Can (1 1 c) Dust: Rotary Duster (1 1 d) Dust: Plunger Duster (1 2 a) Paint: Brush or Roller (1 2 b) Paint: Airless Sprayer (1 3 ) Solid Feed Additive for Feed Through: Cup

Occupational Handler Exposure Data and Assumptions A series of assumptions and exposure factors served as the basis for completing the occupational handler risk assessments. Each assumption and fact or is detailed below on an individual basis. Application rate: A summary of all TCVP occupational use sites and application rates is presented in Appendix C.
Unit Exposures: It is the policy of HED to use the best available data to assess handler exposure. Sources of generic handler data, used as surrogate data in the absence of chemical

- specific data, include PHED 1.1, the AHETF database, the Outdoor Residential Exposure Task Force (ORETF) database, or other registrant

- submitted occupational expo sure studies. Some of these data are proprietary (e.g., AHETF data), and subject to the data protection provisions of FIFRA. The standard values recommended for use in predicting handler exposure that are used in this assessment, known as “unit exposures ”, are outlined in the “Occupational Pesticide Handler Unit Exposure Surrogate Reference Table 19 

## ”, which, along with additional information on HED policy on use of surrogate data, including descriptions of the various sources, can be found at the Agency web site 20



## . A single chemical

- specific exposure study, Monitoring Exposure of Mixer/Loaders and Applicators Treating Agricultural Premises with Tetrachlorvinphos (Rabon ® 50 WP Insecticide) in Handheld Wand

- Type Sprayers, was used as appropriate (i.e., exposure scenario 10c, mix/load and apply WP with high pressure handwand) in the most recently occupational risk assessment for TCVP. 21 

## Per the prior risk assessment, risk s for the exposure scenario were estimated with use of the chemical

- specific exposur e data as well as surrogate PHED data.

The PHED data recommended for the exposure scenario uses unit exposure values (dermal and inhalation) that represent an individual conducting all activities, mixing /loading/applying
, for use of the WP product by hi gh pressure handwand. In contrast, t he chemical

- specific exposure study

19 

### Available: http://www.epa.gov/opp00001/science/handler

- exposure

- table.pdf
20 

### Available: http://www.epa.gov/pesticides/science/handler

- exposure

- data.html
21 

### J. Dawson. Tetrachlorvinphos: F urther Revisions to Occupational Risk Assessment for Uses in the Poultry and Cattle Production Industries. 3/28/2002. D281972.

## Page 31 of 124

was condu cted in a manner which separated out the mixing/loading and application components of the exposure scenario. E xposure scenario 10c has been assessed and estimated risks pres ented separately (i.e., mixer/loader and applicator) with use of the chemical

- specific data
, and for all activities with use of PHED. When applied, t he dermal and inhalation unit exposures resulting for product application result in risk estimates that are very similar to risk estimates using the PHED data

. Non

- cancer and cancer private/farmer and contract/commercial occupational handler risk estimates for exposure scenario 10c are presented separately from the risk summaries for all other occupational h andler exposure scenarios in Appendix I: Table I.2 and Appendix J: Tables J. 2 and J.4, respectively.
The following summarizes the chemical

- specific exposure study:

MRID 42622301: The purpose of this study was to monitor the dermal and inhalation exposur es of workers to TCVP while mixing/loading or applying Rabon ® 50 WP insecticide by handheld wand

- type spreaders to the interior of poultry rearing houses. Four workers were monitored at 2 sites near Seaford, DE. Each worker was monitored for 4 replicates of mixing/loading and 4 replicates of applying , resulting in a total of 32 monitoring units (MUs) . Poultry facilities were sprayed using typical handheld wand

- type spray equipment; Rabon ® 50 WP was loaded using typical open

- pour loading procedures. Work ers mixed/loaded 4 sequential replicates in which each wo rker did 2 replicates of a pre

- mix slurry method (i.e., product was emptied into buckets and mixed to form a slurry then poured and rinsed into a tank) and 2 replicates of open

- pour mixing/loading (i .e., pouring WP from bags directly into the tank hatch). Workers then sprayed 4 replicates subsequent to each batch mixed/loaded.
Workers wore either 100% cotton or 65% polyester/35% cotton coveralls, socks, shoes, and baseball caps with visors. PPE worn during mixing/loading and applying included neoprene gloves and rubber boots. Dermal exposure to the body was estimated from 100% cotton one

piece long underwear “union suits” union suits worn under each worker’s work clothing. Dermal exposure to the head/face and the front and back of neck was estimated with use of 100% cotton fabric dosimeters folded in an aluminum foil frame tape d onto the worker’s cap, outer clothing just to the left/right of center of the chest, and the back of the neck. Hand exposures were estimated by use of a 1:1 isopropanol and distilled water wash. Airborne concentrations of TCVP were collected with use o f personal air pumps affixed with inhalation monitoring tubes.
Measured residues in passive dosimetry matrices were adjusted for mean recoveries of TCVP. T able 6.1 below presents a summary of the arithmetic mean dermal and inhalation exposures from the 16 MUs of mixing/loading and 16 MUs of applying Rabon ® 50 W, and for 8 replicates each of the two mixing methods: pre

- mix slurry and open

- pour mixing/loading.

Table 6.1 Summary of Mean Dermal and Inhalation TCVP Exposures for Mixer/Loaders and Applicat ors of TCVP from Rabon ® 50 WP Mixer/Loaders; 16 MUs (μg/ lb ai) Applicators; 16 MUs (μg/ lb ai) Dermal 373 901 Inhalation 30 7.0

## Page 32 of 124

In some cases, due to the lack of data for an exposure scenario or the unique nature of the scenario
, surrogate exposure data were used as follows:

 Exposure data for the loading/application of dust formulations were used as a surrogate for the loading/application of wettable powders for rotary and plunger duster applications (1 0f , 1 0g ). For exposure scenario 1 0f , expo sure data for plunger dusters were used due to the lack of data for the rotary duster application method.

 Unlike more typical exposure scenarios where a RTU paint is only loaded or applied, for TCVP the paint must be mixed/loa ded for the liquid (1b ), wettable powder (2d), and dust (3a) formulations. These exposure scenarios were assessed using the exposure data appropriate for mixing/loading for each formulation.

 The mixing/loading of wettable powders for handheld/stationary fogger (2b, 2c) was assessed; however, no exposure data are available for the assessment of application with these equipment types.

 For TCVP applications to livestock with a dust formulation via shaker can, a RTU product is not available ; therefore, expo sures from the mixing/loading of the shaker can must be assessed in addition to the application . As a result, the exposure data for the loading/application via a RTU shaker can was used for the assessment of all scenarios relating to the use. The use of these data results in a more protective assessment than would be if the mixing/loading of the dust were assessed separately.

 Exposures from the application of feed (salt or mineral) blocks in livestock

– typically, 5

– 15 per head of cattle or horses

– is assumed to be negligible if gloves are worn when placing the blocks. Further, for these products the greater majority of the active ingredient is contained within the block, thus fu rther reducing the exposure potential.

Area Treated or Amount Handled: The following inputs are consistent with those used in the most recently conducted occupational risk assessment for TCVP and, for those inputs relating to the poultry industry, are r eflective of research conducted by BEAD at that time.

 Groundboom: 100,000 square feet for application s to poultry buildings

 Backpack and manually pressurized handwand: 20,000 square feet for applications to poultry buildings

 Mechanically pressurized han dwand: 100,000 square feet for applications to poultry buildings

 Backpack, handheld/stationary fogger, manually pressurized handwand, mechanically pressurized handwand, rotary spreader: 20,000 birds for direct application to poultry (i.e., approximately 1 square foot/bird)

 B ackrubber/facerubber : 50 gallons

 Paint applications: 2 gallons

The following inputs are based on either the most recently conducted permethrin occupational and residential exposure and risk assessment for similar use patterns 22 

## or best professional judgment of product usage:

22 

### C. Smith. Permethrin : Third Revision of the Occupational and Residential Exposure Assessment for the Reregistration Eligibili ty Decision Document. 4/4/2006. D325428.

## Page 33 of 124

 All handheld equipment : 400 animals treated daily

 Handheld/stationary fogger: 100,000 square feet to poultry buildings

 Plunger, shaker can, spoon : 1,000 birds or 1,000 square feet

 P et collar, pump/trigger spray, and shaker can applications : 8 animals treated daily

 Self

- treating d ust bags: 10 filled daily (assuming a 12.5 lb dust bag)
The following inputs are consistent with EPA regulatory defi nitions for large concentrated animal feeding oper ations (CAFOs) 23 

## . The inputs assume that a single individual is responsible for the food preparation for the entire CAFO and applies the T CVP feed

- through products to the animal feed

.

 Cup, p our on: 1,000 cows, 500 horses, and 6,250 pigs for liquid and sol id feed

- through applications. The number of cows and horses represents the maximum identified for large CAFO operations. The number of pigs was estimated by averaging the maximum number weighing over 55 lbs (2,500) an d less than 55 lbs (10,000) in large CAFO operation s

. Exposure Duration : Occupational handler exposure is expected to be short

- and intermediate

term in duration

. Because of the steady state AChE inhibition exhibited by the OPs, steady state exposures (21 days and longer) were ass essed and presented for occupational exposures to TCVP products.

Mitigation/Personal Protective Equipment: Estimates of non

- cancer inhalation exposure were calculated for various levels of PPE (i.e., respiratory protection) . Results are presented for no respirator, PF5 respirator, PF10 respirator, or EC.

The PPE required for occupational use of TCVP varies by formulation type

. The respiratory protection r equired for the occupational handing of TCVP can, at times, differ from label to label with consideration of the same formulation and exposure scenario. Occupational handler exposures are expected from use of TCVP on pets by veterinarians, veterinary assi stants, and groomers. The pet use formulations include collars, dusts/powders, and pump and trigger sprays. All but one of the TCVP pet product labels do not require PPE
, as these are intended for residential sale as well as for occupational use

. A summar y of PPE required for all TCVP products is presente d in Appendix C

. Days per Year of Exposure: To assess cancer risk, it is assumed that private growers would be exposed 10 days per year and commercial applicators would be exposed 30 days per year. The term “private grower” means that the grower or one of the workers would apply the pesticides to land owned or operated by the grower. Commercial applicators means the applicators are completing multiple applications for multiple clients.

Years per Lifeti me of Exposure: It is assumed that handlers would be exposed for 35 years out of a 78 year lifespan.

23 

### http://www.epa.gov/npdes/pubs/sector_table.pdf

## Page 34 of 124

Lifetime Expectancy: Life expectancy values are from the Exposure Factors Handbook 2011 Edition Table 18

- 1 (U.S. EPA, 2011). The table shows that the overall life expectancy is 78 years based on life expectancy data from 2007. In 2007, the average life expectancy for males

w as 75 years and 80 years for females. Based on the available data, the recommended value for use in cancer risk assessments is 78 years.

Occupational Handler Non

- Cancer Exposure and Risk Estimate Equations The algorithms used to estimate non

- cancer exposure and dose for occupational handlers can be found in Appendix D

. Combining Exposures/Risk Estimates
Although occupational dermal and inhalation exposures are anticipated for TCVP, risks have been estimated for inhalation exposures only due to the lack of dermal hazard. Therefore, no combined occupational exposures/risk estimates have been quantified.
Summary of Occupational Handler Non

- Cancer Exposure and Risk Estimates

Of the 172 total occupational ha ndler exposure scenarios assessed, the majority (152) are not of concern (i.e., steady state inhalation MOEs are ≥ 300) with currently required personal protective equipment (PPE) (i.e., respiratory protection). Of the remaining 20 handler exposure scenar ios, an additional 16 are not of concern with consideration of increasing levels of respiratory protection (i.e., four occupational handler exposure scenarios result in estimated risks of concern despite the addition of respiratory protection or engineerin g controls). These four handler scenarios are all dust formulations (mixing/loading/applying TCVP by rotary duster, self

- treating dust bag, or shaker can). A summary of all non

- cancer occupational handler exposure scenarios is presented in Appendix I. Fo r risk management purposes, the currently labeled level of respiratory protection and EC has been identified (bolded) for each individual exposure scenario.

Occupational Handler Cancer Exposure and Risk Equations

Cancer risk estimates were calculated using a linear low

- dose extrapolation approach in which a n LADD is first calculated and then compared with a Q1* that has been calculated for TCVP based on dose response data in the appropriate toxicology study (Q1* = 1.83 x 10

- 3 

## (mg/kg/day)

- 1). ADD level s were used as the basis for calculating the LADD values. Dermal and inhalation ADD values were first added together to obtain combined ADD values. LADD values were then calculated and compared to the Q1* to obtain cancer risk estimates. The algorithms used to estimate the LADD and cancer risk for occupational handlers can be found in Appendix D

. Summary of Occupational Handler Cancer Exposure and Risk Estimates

Occupational cancer risks were estimated for both private/farmer and contract/commercial ha ndlers. Cancer risks range from 10

- 10 

## to 10

- 5 

## for private/farmer handlers and from 10

- 10 

## to 10

- 4 

## for contract/commercial handlers with currently required PPE.

## Page 35 of 124

Unlike the occupational handler non

- cancer risk estimates which were based only on inhalation exposures, the occupational handler cancer risk estimates are quantified based on both dermal and inhalation exposures. This is because, despite the determination of the lack of dermal hazard for TCVP, dermal exposures from TCVP must be quantified for pu rpose of cancer risk assessment. As previously described, the PPE required for the occupational use of TCVP varies by formulation type

. For example, for feed through (solid and liquid food additives) and feed blocks, occupational handlers are required to wear baseline clothing (i.e., long sleeved shirt, long pants, shoes and socks) and gloves. For all other end

- use labels with livestock and outdoor perimeter uses, required PPE can vary dependent on the application type or equipment and can range from bas eline clothing and gloves, to the addition of coveralls, or respiratory protection.
A summary of occupational cancer risks as estimated at all levels of personal protection and with use of engineering controls is presented in Appendix J. Table J.1 pre sents cancer risks for private/farmer handlers and Table J.2 risks for contract/commercial handlers. For risk management purposes, the currently labeled level of respiratory protection and EC has been identified (bolded) for each individual exposure scena rio.

6.2 Occupational Post

- application Exposure/Risk Estimates
HED uses the term post

- application to describe exposures that occur when individuals are present in an environment that has been previously treated with a pesticide (also referred to as re

en try exposure). Such exposures may occur when workers enter previously treated areas to perform job functions, including activities related to crop production, such as scouting for pests or harvesting. Post

- application exposure levels vary over time and d epend on such things as the type of activity, the nature of the crop or target that was treated, the type of pesticide application, and the chemical’s degradation properties.

Occupational post

- application exposures are not anticipated for TCVP as the ma jority of use sites are not to foliar surfaces. The use of TCVP outdoors as a perimeter treatment is not expected to result in occupational post

- application exposure as reentry activities related to crop production (e.g., scouting, harvesting) are not ant icipated for this use pattern.

## Page 36 of 124

A ppendix A : Summary of OPP’s ChE Policy & Use of BMD Modeling

OPP’s ChE policy (USEPA, 2000 24 

## ) describes the manner in which ChE data are used in human health risk assessment. The following text provides a brief summary of that document to provide context to points of departure selected. AChE can be inhibited in the central or peripheral nervous tissue. Measurements of AChE or cholinesterase (ChE) inhibition in peripheral tissues (e.g., liver, diaphragm, heart, lung etc.) are rare. As such, experimental laboratory studies generally measure brain (central) and blood (plasma and red blood cell [RBC]) ChE. Blood measures do not represent the target tissue, per se, but are instead used as surrogate measures for peripheral toxicity in studies with laboratory animals or for peripheral and/or central toxicity in humans. In addition, RBC measur es represent AChE, whereas plasma measures are predominately butyryl

- ChE (BuChE). Thus, RBC AChE data may provide a better representation of the inhibition in target tissues. As part of the dose response assessment, evaluations of neurobehavior and clini cal signs are performed to consider the dose response linkage between AChE inhibition and apical outcomes. Refinements to OPP’s use of ChE data have come in the implementation of BMD approaches in dose response assessment. Beginning with the OP cumulative risk assessment (CRA), OPP has increased its use of BMD modeling to derive PoDs for AChE inhibiting compounds. Most often the decreasing exponential empirical model has been used. OPP does not have a defined benchmark response (BMR) for OPs. However, the 10% level has been used in the majority of dose response analyses conducted to date. This 10% level represents a 10% reduction in AChE activity (i.e., inhibition) compared to background (i.e., controls). Specifically, the BMD 10 

## is the estimated dose where ChE is inhibited by 10% compared to background. The BMDL 10 

## is the lower confidence bound on the BMD10. The use of the 10% BMR is derived from a combination of statistical and biological considerations. A power analysis was conducted by the ORD o n over 100 brain AChE datasets across more than 25 OPs as part of the OP CRA (USEPA, 2002). This analysis demonstrated that 10% is a level that can be reliably measured in the majority of rat toxicity studies. In addition, the 10% level is generally at o r near the limit of sensitivity for discerning a statistically significant decrease in ChE activity in the brain compartment and is a response level close to the background brain ChE level. With respect to biological considerations, a change in 10% brain AChE inhibition is protective for downstream clinical signs and apical neurotoxic outcomes. RBC AChE inhibition data tend to be more variable than brain AChE data. OPP begins its BMD analyses using the 10% BMR for RBC AChE inhibition. However, BMRs up to 20% could be considered on a case by case basis, as long as such PoDs are protective for brain AChE inhibition, potential peripheral inhibition, and clinical signs of neurotoxicity.

24 

### USEPA (2000) Office of Pesticide Programs, US Environmental Protection Agency, Washington DC 20460. August 18, 2000 Office of Pesticide Programs Science Policy of The Use of Data on Cholinesterase Inhibition for Risk Assessments of Organophosphorous and Carbamate Pesticides. http://www.epa.gov/oppfead1/trac/science/cholin.pdf

## Page 37 of 124

Appendix B : Results for BMD/BMDL modeling for TCVP

BMD analyses were performed with EPA’s Benchmark Dose Software (Version 2.4) using an exponential model for continuous data 25 

## . The Hill model was also performed for some data sets, but did not result in the best fit for the data. The data selected for evaluation consisted of decreased brain and red blood cell (RBC) cholinesterase (ChE) activities. Data were analyzed from a 21

- day oral toxicity study (MRID 45570601), a 13

- week subchronic oral toxicity study (MRID 43371201), and a 2 year chronic oral toxicity study (MRID 429 80901); a gestational comparative cholinesterase assay (CCA; MRID 48291101); and a 28

- day inhalation toxicity study (MRID 48803501). All data from these studies were considered; however, some data were not amenable to BMD analysis. OPP has used the exp onential model for modeling AChE activity for the OP and N

- methyl carbamate cumulative risk assessments and with multiple single chemical risk assessments of ChE

- inhibiting pesticides. Model runs for ChE activity were conducted with an appropriate benchma rk response level (10%). As such the BMD 10 

## (estimated dose to result in 10% change from background levels) and BMDL 10 

## (the lower 95% confidence level on the BMD 10 

## ) are provided in the output. Statistical (e.g., goodness of fit values) and graphical resul ts were used in model evaluation. The results of the repeated oral and inhalation dosing BMD analyses are summarized below in Table B . Good model fit (p>0.1) was obtained for the majority of the analyses, with any exceptions being noted. For exposure t o repeated doses the BMDL 10 

## for ChE inhibition in the adult female RBCs were similar in the 13

- week subchronic study and the 21

- day oral toxicity study (8.0 mg/kg/day vs 6.7 mg/kg/day, respectively). Although data from the shorter duration study resulted in a slightly lower BMDL, visual examination of the modeled data provided greater confidence in the 13

- week study. For inhalation exposure, the adult male was about twice as sensitive as the adult female (0.023 mg/L in males vs 0.050 mg/L in females).

Table B

. Results of BMD Exponential Modeling for Brain and RBC ChE Data on TCVP, Repeated Oral Dosing Studies in Rats, Ranging in Duration from 21 days to 2 years.

TCVP Study Age/Sex Compartment BMD Results

BMD 10 

### BMDL 10



### MRID 43371201

13W Oral

– 13 Weeks Adult Male Brain No dose response (analysis not performed)

Adult Female Brain No dose response

Adult Male RBC 61.6 mg/kg/day 26.3 mg/kg/day

Adult Female RBC 10.5 mg/kg/day 8.0 mg/kg/day

25 

### J. Bever. Tetrachlorvinphos: Benchmark Dose Analysis of Subchronic and Chronic Studies to Support Derivation of Points of Departure. 5/20/2014. TXR # 0056970. D420286.

## Page 38 of 124

Table B

. Results of BMD Exponential Modeling for Brain and RBC ChE Data on TCVP, Repeated Oral Dosing Studies in Rats, Ranging in Duration from 21 days to 2 years.

TCVP Study Age/Sex Compartment BMD Results

BMD 10 

### BMDL 10


### MRID 42980901

Chronic Oral Tox

– 364, 539, and 721 Days Adult Female RBC No dose

- response effect was observed at 364, 539, or 721 days

MRID 45570601

21D Oral Tox

– 21 Days Adult Female Brain 14.7 mg/kg/day 12.2 mg/kg/day

RBC 9.9 mg/kg/day 6.7 mg/kg/day

MRID 48803501

28D Inhalation

– 28 Days Adult Male RBC 0.122 mg/L 0.023 mg/L

Adult Female RBC 0.394 mg/L 0.050 mg/L



## Appendix C

– Summary of TCVP Labels and Use Directions

## Page 39 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

Feed Through ( Solid Additive)

270

- 164

Horse Oral

Larvicide

Cup 1,100 lb horse: 0.0015 lb ai/animal/day (2.468% ai)

Baseline

clothing and gloves Feed to horses through top dress on

grain or mixed with the horse’s total ration. 300

- 500 lb horse: Feed 2/5 oz. per horse per day 500

- 700 lb horse: Feed 2/5 oz. per horse per day 700

- 900 lb horse: Feed 2/5 oz. per horse per day 900

- 1,100 lb horse: Feed 2 /5 oz. per horse per day For larger horses over 1,00 lbs. of body weight feed 1⁄4 oz. for each 250 lbs.

270

- 165 1,100 lb horse: 0.00077 lb ai/animal/day (1.234% ai) Feed the recommended dosage to each horse separately to make certain he receives the full portion. Feed to horses through top dress on grain or mixed with the horse’s total ration. 300

- 500 lb horse: Feed 2/5 oz. per horse per day 500

- 700 lb horse: Feed 2 /5 oz. per horse per day 700

- 900 lb horse: Feed 2/5 oz. per horse per day 900

- 1,100 lb horse: Feed 2/5 oz. per horse per day For larger horses over 1,100 lbs. of body weight feed 1⁄4 oz. for each 250 lbs.

7698

- 7 Beef Cattle

Oral Larvicide 1,400 lb beef cow (estimated max): 0.0022 lb ai/animal/day Mix uniformly with cattle feeds following standard mixing procedures. Common feed mixing equipment (i.e., vertical mixers, horizontal blenders, mixer/feeder truck) may be used to prepare formul ated feeds. Can be offered by force

- feeding or free

- choice feeding, but not both. Feed 1/3 lb per 100 lbs. per month, or an average daily intake of 70 mg daily.

73600

- 4 Cattle and

Horse Oral Larvicide 0.0017 lb ai/animal/day To prepare a larvicidal ration, mix 1.5 lbs. of product per ton of complete mixed ration. Full feed this larvicidal ration to feeder cattle weighing from 400

– 1,400 lbs or to dairy cattle at a rate sustaining milk production, but not less than 2.6 lbs of the ration per 100 lbs of body weight daily.

## Page 40 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

Product can also be mixed with concentrate feeds that will provide 792 mg per animal per day.

Feed Through (Liquid Additive)

6552

- 17 Cattle

(concentrate feed)

Cup/Pour 1,700 lb cow (labeled max): 0.0039 lb ai/animal/day

Baseline

clothing and gloves This product can be used to prepare

concentrate feeds that will provide 70 mgs. of ai/ 100 lbs. body weight daily. Feed the appropriate concentrate indicated to cattle weighing between 400 and 1,200 lbs. For large cattle weighing between 1,200 and 1,700 lbs, increase the amount of premix per ton of concentrate to 1.5 times that indicated.

Cattle (complete ration) 1,400 lb cow (labeled max feeder cow): 0.0022 lb ai/animal/day This product can be used to prepare rations containing 26.4 mg of ai/ pound of complete ration. Full feed the ration to feeder cattle weight from 400 to 1,400 lbs, but not less than 2.6 pounds of the ration per 100 lbs of body weight daily.

Swine 0.00060 lb ai/animal/day Mix 2.6 lbs of this product per ton of meal type feed and offer 4

- 6 lbs of feed per animal per day. This is equivalent to 45.4 mg of product per lb of feed.

Horse 1,100 lb horse (estimated max): 0.0017 lb ai/animal/day Use this product to prepare concentrate feeds/topdressings that will provide 70 mgs of ai per 100 lbs of weight daily.

11556

- 160 Cattle 1,700 lb cow (labeled max): 0.0039 lb ai/animal/day

Baseline

clothing and gloves Roughage fed separately: This prod uct

is used to prepare concentrate feeds that will provide 70 mg ai per 100 lbs body weight. Feed the appropriate larvicidal concentrate to cattle weighing between 400 and 1,200 lbs. For large cattle weighting between 1,200 and 1,700 lbs, increase the am ount of premix per ton of concentrate to 1.5 times that indicated.

1,400 lb cow (labeled max): 0.0022 lb ai/animal/day No other roughage fed: Mix 1.5 lbs of product per ton of complete mixed ration containing both grain and roughage. Full feed this complete ration to feeder cattle weighing from 400 to 1,400 lbs or to dairy cattle at a rate to sustain milk production, but n ot less than 2.6 lbs of the ration per 100 lbs of body weight daily.

Swine 0.00060 lb ai/animal/day Mix 2.6 lbs of this product per ton of meal type feed and offer 4 to 6 lbs of

## Page 41 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

feed per animal per day. This is equivalent to 45.5 mg ai per pound of feed.

Horse 1,100 lb horse (estimated max): 0.0017 lb ai/animal/day Use this product to prepare concentrate feeds that will provide 70 mg ai per 100 lbs body weight daily.

Feed Block

6552

- 17

Cattle and

Horse Oral Larvicide Hand

Dispersal 1,100 lb horse

(estimated max): 0.0017 lb ai/animal/day

1,400 lb cow (estimated max): 0.0022 lb ai/animal/day

(0.473% ai)

Baseline

clothing and gloves Provide 1 block per 5 head of cattle or

horses. Feed at a daily rate of 0.07 grams of Larvicide in 0.5 ounces of block per 100 pounds of body weight.

7698

- 17 1,100 lb horse (estim ated max): 0.0017 lb ai/animal/day

1,400 lb cow (estimated max): 0.0022 lb ai/animal/day Place in dry spots near loafing and watering areas. Cattles (or horses) should consume 1.05 lbs of the product per 100 lbs of body weight per month. This will supply the recommended average daily intake of 70 mg per 100 lbs of body weight.

7698

- 18 1, 100 lb horse (estimated max): 0.0017 lb ai/animal/day

1,400 lb cow (estimated max): 0.0022 lb ai/animal/day Cattles (or horses) should consume 0.68 lbs of the product per 100 lbs of body weight per month. This will supply the recommended average daily intake of 70 mg per 100 lbs of body weight.

9078

- 12 1,100 lb horse (estimated max): 0.0017 lb ai/animal/day

1,400 lb cow (estimated max): 0.0022 lb ai/animal/day

(0.31% ai) Feed approximately 1⁄2 lb block per 1,000 lb animal daily.

9374

- 8 1,100 lb horse (estimated max): Allow free choice for cattle and horses. Cattle and horses should consume an average of 0.8 oz of the product per 100

## Page 42 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

0.0017 lb ai/animal/day

1,400 lb cow (estimated max): 0.0022 lb ai/animal/day

(0.30% ai) lbs of bod y weight per day. This will supply the recommended average daily intake of 70 mg.

55392

- 3 1,100 lb horse (estimated max): 0.0017 lb ai/animal/day

1,400 lb cow (estimated max): 0.0022 lb ai/animal/day

(0.30% ai) Provide one block per 15

- 20 head of cattle or horses. Consumption should average 0.83 oz of the block per 100 lbs. This will supply the recommended average daily intake of 70 kg.

73600

- 1 1,100 lb horse (estimated max): 0.0017 lb ai/animal/day

1,400 lb cow (estimated max): 0.0022 lb ai/animal/day

(0.49% ai) Feed 1 block per 5 head of cattle or horses. Feed blocks at the rate of 0.5 oz per 100 lb of bodyweight per day. This intake will supply 0.07 g of larvicide per 100 lb. of bodyweight per day

.

73600

- 3 1,100 lb horse (estimated max): 0.0017 lb ai/animal/day

1,400 lb cow (estimated max): 0.0022 lb ai/animal/day

(0.49% ai) Feed only as a free choice source of salt, other minerals or vitamins. The product should be fed at a level to provide 70 mg per 100 lb of bodyweight per day.

73600

- 5 1,100 lb horse (estimated max): 0.0017 lb ai/animal/day

1,400 lb cow Feed one block per 10

- 15 head of cattle or horses. Feed blocks at the rate of 0.88 oz. per 100 lb. of body weight per day. This intake will supply 0.07 g of Larvicide per 100 lb. of bodyweight per day.

## Page 43 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

7360 0

- 6 (estimated max): 0.0022 lb ai/animal/day

(0.30% ai) Feed 1 block per 5 head of cattle or horses. Feed blocks at the rate of 0.88 oz. per 100 lb. of bod weight per day. This intake will supply 0.7 g of Larvicide per 100 lb. of bodyweight per day.

Dust

11556

- 158 Beef Cattle

and Dairy Cattle Shaker

Can, Rotary Duster, Spoon 2 oz. dust: 0.0038 lb

ai

4 oz dust: 0.0075 lb ai

(3% ai) M/L/A:

Baseline clothing, gloves, and PF5 respirator Hand dusting: apply 2 oz. of dust by

shaker can, rotary duster or by spoon to the upper portions of the bac k, neck and poll, and to the face.

Also can be used after grubs have encysted by applying 3

- 4 oz. of dust down the backline and rubbing in.

Hand Pour 12.5 lbs (estimated

max dust bag): 0.38 lb ai per dust bag Loaders and others handling dust bags: Baseline clothing, gloves Self

- treating dust bag: put dust in a cotton cloth or double burlap bag or use prepacked weather proof cattle dust bags and hang in door exits or alleyways leading from animal buildings, salt or mineral blocks or watering holes. The dust bag can also be placed in a loafing shed, holding pens, feedlots, near watering holes or other areas where cattle gather.

Swine Hand,

Power Duster, Shaker Can 4 oz dust/animal:

0.0075 lb ai/animal

1 lb. per 150 sq. ft: 0.00020 lb/ sq ft.

M/L/A :

Baseline clothing, gloves, and PF5 respirator Hand dusting: apply 3

- 4 oz of dust by

hand or power duster to each animal.

In severe infestations, both animals and bedding may be treated. One lb. of 3% dust should be applied per 150 sq. ft.

Poultry Plunger,

Rotary Type Duster, Shaker can Duster 0.00010 lb ai/ b nird Wire cage housing: Apply 1 lb dust/300 birds with plunger or rotary type duster or shaker can duster.

Plunger, Rotary Type Duster 0.00030 lb ai/ sq ft Floor management litter: Apply 1 lb/100 sq ft with plunger or rotary type duster.

Or, apply 3 to 8 oz/ 100 sq ft with plunger or rotary type duster for treatment of darkling beetles. Plunger, Rotary Type Duster, Shaker can Duster 0.00060 lb ai/bird Dust box: Apply 2 lbs/100 birds

## Page 44 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

Paint 0.030 lb ai/ gallon

(1 gallon treats 800 sq ft) Roost paint: Make a thick slurry by mixing 1 lb of dust with 1 pint of water. Apply 1 lb/100 sq ft.

11556

- 182 Beef Cattle

and Dairy Cattle Shaker can,

Rotary Duster, S poon 1 oz. dust: 0.0038 lb

ai

2 oz dust: 0.0075 lb ai

(6% ai) M/L/A:

Baseline clothing, gloves, and PF5 respirator Hand dusting: apply 1 oz. of dust by

shaker can, rotary duster or by spoon to the upper portions of the back, neck and poll, an d to the face.

Also can be used after grubs have encysted by applying 1.5

- 2 oz. of dust down the backline and rubbing in.

Hand Pour 12.5 lbs (estimated

max dust bag): 0.75 lb ai per dust bag Loaders and others handling dust bags: Baseline clothing, gloves Self

- treating dust bag: put dust in a cotton cloth or double burlap bag or use prepacked weather proof cattle dust bags and hang in door exits or alleyways leading from animal buildings, salt or mineral blocks or watering holes. The dust bag can al so be placed in a loafing shed, holding pens, feedlots, near watering holes or other areas where cattle gather.

Swine Hand,

Power Duster, Shaker Can 2 oz dust/animal:

0.0075 lb ai/animal

0.5 lb. per 150 sq. ft: 0.00020 lb/ sq ft.

M/L/A:

Baseline clothing, gloves, and PF5 respirator Hand dusting: apply 1.5

- 2 oz of dust by

hand or power duster to each animal.

In severe infestations, both animals and bedding may be treated. One half lb. of 6% dust should be applied per 150 sq. ft.

Poultry Plunger,

Rotary Type Duster, Shaker Can Duster 0.00010 lb ai/ bird Wire cage housing: Apply 1 lb dust/600 birds with plunger or rotary type duster or shaker can duster.

Plunger, Rotary Type Duster 0.00030 lb ai/ sq ft Floor management litter: Apply 0.5 lb/100 sq ft with plunger or rotary type duster.

Or, apply 1.5 to 4 oz/ 100 sq ft with plunger or rotary type duster for treatment of darkling beetles. Plunger, Rotary Type Duster, Shaker Can Duster 0.00060 lb ai/bird Dust box: Apply 1 lbs/100 birds

Paint 0.030 lb ai/ gallon Roost paint: Make a thick slurry by mixing 1 lb of dust with 1 pint of water. Apply 0.5 lb/100 sq ft.

## Page 45 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

(1 gallon treats 800 sq ft)

19713

- 340 Beef Cattle

and Dairy Cattle Shaker can,

Rotary Duster, S poon 2 oz. dust: 0.0038 lb

ai

4 oz dust: 0.0075 lb ai

(3% ai)

Baseline

clothing and gloves Hand dusting: apply approximately 2

oz. of dust by shaker can, rotary duster or by spoon to the upper portions of the back, neck and poll, and to the face.

Hand Pour 12.5 lbs (estimated

max dust bag): 0.38 lb ai per dust bag Self

- treating dust bag: put dust in a cotton cloth or durable bag or use pre

packed weather proof cattle dust bags and hang in barn door exits or alleyways leading from animal buildings, salt or mineral blocks or watering holes.

Swine Hand,

Power Duster, Shaker Can 2 oz dust/animal:

0.0038 lb ai/animal

1 lb. per 150 sq. ft: 0.00020 lb/ sq ft Hand dusting: apply 1.5

- 2 oz of dust by conventional hand or power duster to each animal with special attention given to the neck and around the ears.

One lb of 3% dust should be applied per 150 sq ft of bedding.

47000

- 113 Beef Cattle

and Dairy Cattle Shaker can,

Rotary Duster, S poon 2 oz. dust: 0.0038 lb

ai

4 oz dust: 0.0075 lb ai

(3% ai)

Baseline

clothing and gloves Hand dusting: apply 2 oz. of dust by

shaker can, rotary duster or by spoon to the upper portions of the back, neck and poll, and to the face.

Also can be used after grubs have encysted by applying 3

- 4 oz. of dust down the backline and rubbing in.

Hand Pour 12.5 lbs (estimated

max dust bag): 0.38 lb ai per dust bag Self

- treating dust bag: put dust in a cotton cloth or double burlap bag or use prepacked weather proof cattle dust bags and hang in door exits or alleyways leading from animal buildings, salt or mineral blocks or watering holes. The dust bag can also be placed in a loafing shed, holding pens, feedlots, near watering holes or other areas where cattle gather.

Swine Hand,

Power Duster, Shaker Can 4 oz dust/animal:

0.0075 lb ai/animal

1 lb. per 150 sq. ft: 0.00020 lb/ sq ft. Hand dusting: apply 3

- 4 oz of dust by hand or power duster to each animal.

In severe infestations, both animals and bedding may be treated. One lb. of 3% dust should be applied per 150 sq. ft.

Poultry Plunger,

Rotary Type 0.00010 lb ai/ bird Wire cage housing: Apply 1 lb dust/300 birds with plunger or rotary type duster or shaker can duster.

## Page 46 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

Duster, Shaker Can

Plunger, Rotary Type Duster 0.00030 lb ai/ sq ft Floor management litter: Apply 1 lb/100 sq ft with plunger or rotary type duster.

Or, apply 3 to 8 oz/ 100 sq ft with plunger or rotary type duster for treatment of darkling beetles. Plunger, Rotary Type Duster, Shaker Can Duster 0.00060 lb ai/bird Dust box: Apply 2 lbs/100 birds

Paint 0.030 lb ai/ gallon

(1 gallon treats 800 sq ft) Roost paint: Make a thick slurry by mixing 1 lb of dust with 1 pint of water. Apply 1 lb/100 sq ft.

47000

- 122 Beef Cattle

and Dairy Cattle Shaker

Can, Rotary Duster, Spoon 2 oz. dust: 0.0038 lb

ai (3% ai)

Baseline

clothing and gloves Hand dusting: apply 2 oz. of dust by

shaker can, rotary duster or by spoon to the upper portions of the back, neck and poll, and to the face.

Hand Pour 12.5 lbs (estimated

max dust bag): 0.38 lb ai per dust bag Self

- treating dust bag: put dust in a cotton cloth or double burlap bag or use prepacked weather proof cattle dust bags and hang in door exits or alleyways leading from animal buildings, salt or mineral blocks or wat ering holes. The dust bag can also be placed in a loafing shed, holding pens, feedlots, near watering holes or other areas where cattle gather.

Swine Hand,

Power Duster, Shaker Can 4 oz dust/animal:

0.0075 lb ai/animal

1 lb. per 150 sq. ft: 0.00020 lb/ sq ft. Hand dusting: apply 3

- 4 oz of dust by hand or power duster to each animal.

In severe infestations, both animals and bedding may be treated. One lb. of 3% dust should be applied per 150 sq. ft.

47000

- 123 Beef Cattle

and Dairy Cattle Shaker

Can, Rotary Duster, Spoon 2 oz. dust: 0.0013 lb

ai (1% ai) Baseline

clothing, coveralls, gloves and dust mist respriator Hand dusting: apply 2 oz. of dust by

shaker can, rotary duster or by spoon to the upper portions of the back, neck and poll, and to th e face.

Hand Pour 12.5 lbs (estimated

max dust bag): 0.13 lb ai per dust bag Self

- treating dust bag: put dust in a cotton cloth or double burlap bag or use prepacked weather proof cattle dust bags. Suspend bags in gateways or lanes through which the animals pass daily for water, feed or minerals. The dust

## Page 47 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

bag can also be placed in a loafing shed, holding pens, feedlots, near watering holes or other areas where cattle gather.

Hand, Power Duster 12 oz dust/animal:

0.0075 lb ai/animal

3 lb. per 150 sq. ft: 0.00020 lb/ sq ft. Hand dusting: apply 9

- 12 oz of dust by hand or power duster to each animal.

In severe infestations, both animals and bedding may be treated. Three lbs of 1% dust should be applied per 150 sq. ft.

Horse Hand,

Shaker Can 6 oz. dust/animal:

0.0038 lb ai/animal

No application rate defined for premise dusting.* Apply 6 oz by shaker can, hand duster, grooming brush or dust mitt. Cover upper portions of the back, neck and to the face, mane and tail for added control of face flies.

For premise dusting, apply to barn or stall area floors where manure accumulates.*

Dogs (Kennels) Plunger

Duster, Shaker Can No application rate

defined.* Occasional dusting in and around sleeping quarters and other areas will help free area of ticks and fleas. Dust bedding as well.*

47000

- 125 Beef Cattle

and Dairy Cattle Shaker

Can, Rotary Duster, Spoon 2 oz. dust: 0.0038 lb

ai (3% ai)

Baseline

clothing and gloves Hand dusting: apply 2 oz. of dust by

shaker can, rotary duster or by spoo n to the upper portions of the back, neck and poll, and to the face.

Hand, Pour 12.5 lbs (estimated

max dust bag): 0.38 lb ai per dust bag Self

- treating dust bag: put dust in a cotton cloth or double burlap bag or use prepacked weather proof cattle dust bags and hang in door exits or alleyways leading from animal buildings, salt or mineral blocks or watering holes. The dust bag can also be placed in a loafing shed, holding pens, feedlots, near watering holes or other areas where cattle gather.

Swine Hand,

Power Duster, Shaker Can 4 oz dust/animal:

0.0075 lb ai/animal

1 lb. per 150 sq. ft: 0.00020 lb/ sq ft. Hand dusting: apply 3

- 4 oz of dust by hand or power duster to each animal.

In severe infestations, both animals and bedding may be trea ted. One lb. of 3% dust should be applied per 150 sq. ft.

Poultry Plunger,

Rotary Type Duster, Shaker can Duster 0.00010 lb ai/ bird Wire cage housing: Apply 1 lb dust/300 birds with plunger or rotary type duster or shaker can duster.

## Page 48 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

Plunger, Rotary Type Duster 0.00030 lb ai/ sq ft Floor management litter: Apply 1 lb/100 sq ft with plunger or rotary type duster.

Or, apply 3 to 8 oz/ 100 sq ft with plunger or rotary type duster for treatment of darkling beetles. Hand 0.00060 lb ai/bird Dust box: Apply 2 lbs/100 birds

Paint 0.030 lb ai/ gallon

(1 gallon treats 800 sq ft) Roost paint: Make a thick slurry by mixing 1 lb of dust with 1 pint of water. Apply 1 lb/100 sq ft.

Emulsifiable Concentrate Spray

11556

- 16 2 Beef Cattle

Spray 0.026 lb ai/animal (23% ai)

Baseline

clothing, coveralls, and gloves Dilute 1 gallon of product in 75 gallons

of water. Use between 0.5 and 1 gallon of diluted spray solution per animal.

0.039 lb ai/animal For severe tick infestations, dilution may be increased to 1 gallon in 50 gallons water.

Lactating Dairy Cattle 0.0049 lb ai/animal Dilute 1 gallon of product in 200 gallons of water. Direct spray to cover thoroughly with up to 0.5 gallon of the dilution per animal.

Beef and Dairy Cattle Backrubber

or Facerubber 0.077 lb/gallon Dilute 1 gallon of product in 25 gallons water. Pour diluted solution into oil reservoir of mechanical rubbing devices or pour 1 gallon per 20 feet on burlap or rope backrubbers.

Poultry (Caged) Spray 0.039 lb ai/100 birds

0.00031 lb ai/bird Dilute 1 gallon product in 50 gallons of water. Apply 1 gallon of dilution/100 birds under high pressure. For individual bird treatment, apply 1 oz/ bird. Poultry (Chickens on Litter) 0.000078 lb ai/ sq ft Dilute 1 gallon product in 50 gallons of water. Apply 1

- 2 gallons of dilution/1,000 square feet evenly with penetration of litter surface.

Poultry Roost Paint

or Spray 0.077 lb ai/ gallon Dilute 1 gallon of product in 25 gallons of water. Apply 1 pint of dilution/100 ft of roost area with brush or spray.

Buildings 0.00077 lb ai/ sq ft Dilute 1 gallon of product in 25 gallons of water. Apply 1 gallon of dilution/100

- 150 sq ft to thoroughly cover walls, ceilings, floors, cracks and crevices using high pressure spray. Poultry and Livestock Facilities Spray 0.00015 lb ai/ sq ft Residual surface spray: Dilute 1 gallon of product in 25 gallons of water. Apply 1 gallon of dilution/500

- 1,000 sq

## Page 49 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

ft. Extreme infestations may necessitate increasing the diluted spray to 1 gallon product per 12.5 gallon water.

0.00077 lb ai/ sq ft Larvicide: Dilute 1 gallon of product in 25 gallons of water. Apply 1 gallon of dilution/100 sq ft.

Kennels 0.000078 lb ai/ sq ft Dilute 1 gallon of product in 50 gallons of water. Apply 1 gallon of dilution/500

- 1,000 sq ft as a spot treatment only once per year.

67517

- 33 Beef Cattle Spray 0.032 lb ai/animal (24% ai) Baseline,

gloves, and organic vapor respirator Dilute to a 0.30%

- 0.50% solution.

Use between 0.5 to 1 gallon of spray per animal. Lactating Dairy Cattle 0.0013 lb ai/ animal Dilute to a 0.040% solution. Use 0.50 gallon of spray per animal.

Beef and Lactating Dairy Cattle Backrubber 0.064 lb ai/gallon Baseline, gloves, coveralls, and organic vapor respirator Dilute to a 1.0% solution. Mix with #2

diesel oil or any approved backrubber base oil.

Swine

Spray,

High Pressure Sprayer 0.016 lb ai/animal

Baseline, gloves, and organic vapor respirator Dilute to a 0.5% solution. Apply a

coarse spray using 0.25 to 0.5 gallon per head to thoroughly wet the animal.

Poultry (Wire Cage) 0.032 lb ai/100 birds (gallon)

0.00025 lb ai/bird Dilute to a 0.5% solution. Apply 1 gallon/100 birds directly to birds, spray vent and fluff areas from below. For individual bird treatment, apply 1 oz of mixture per bird. Poultry (Floor Management) 0.000064 lb ai/ sq ft (2 gallons) Dilute to 0.5% solution. Apply 1

- 2 gallons/1,000 sq ft evenly for penetration to litter surface. Poultry (Roost Paint) Paint 0.064 lb ai/ gallon Dilute to 1.0% solution. Apply 1 pint solution/100 sq ft. Treat with a brush or spray thoroughly.

Poultry (Fowl Tick) Power

Sprayer 0.00064 lb ai/ sq ft Dilute to 1.0% solution. Apply 1 gallon solution/100

- 150 sq ft to walls, ceiling, floors, cracks and crevices with a power sprayer. Poultry (Flies Residual)

Spray 0.00013 lb ai/ sq ft Dilute to 1.0% solution. Apply 1 gallon/500

- 1,000 sq ft thoroughly to point of runoff to walls, ceilings, and where flies congregate and feed. Poultry (Larvicide) 0.00064 lb ai/ sq ft Dilute to 1.0% solution. Apply 1 gallon solution/100 sq ft of d roppings. Woody Borders of Kennels, Yards, Campgrounds, Recreational 0.032 lb ai/ sq ft Dilute to 0.5% solution. Apply as a spot spray.

## Page 50 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

Parks, Footpaths and Roadways Wettable Powder

11556

- 156 Beef Cattle

Spray 0.040 lb ai/ animal

(1 gallon)

MLA for

dusting, low pressure handwand and paint applications: Baseline clothing, gloves, coveralls, dust mist respirator

All other MLA and other handlers: Baseline clothing and gloves Dilute to a 0.35

- 0.50% solution. Use a

low pressure coarse spray and appl y to point before runoff. Use between 0.5 to 1 gallon of spray solution per animal.

Swine 0.020 lb ai/animal

(0.5 gallon) Dilute to a 0.50% solution. Apply as a low pressure coarse spray and apply only to point before runoff. Use 0.25 to 0.50 gallo n maximum solution per head to treat.

Poultry (Wire Cages) 0.00040 lb ai/ bird (gallon)

0.00031 lb ai/bird (1 oz) Dilute to a 0.50% solution. Apply directly to birds (1 gallon solution/100 birds). For individual bird treatment apply 1 oz of the mixture per bird. Use power sprayer.

Poultry (Floor Management Dusting) Handheld

Fogger, Plunger Duster, Stationary Fogger 0.0016 lb ai/ bird Apply 2.5 oz wettable powder/50 birds.

Poultry (Floor Management Roost Paint) Paint 0.080 lb ai/ gallon

(1 gallon treats 800 sq ft) Dilute to a 1.0% solution. Treat with brush or spray thoroughly using 1 pint/100 ft.

Poultry (Floor Management Litter) Spray 0.00080 lb ai/ sq ft (2 gallons) Dilute to a 0.50% solution. Apply 1

- 2 gallons solution/100 sq ft for penetration of litter surface. Handheld Fogger, Rotary Duster, Stationary Fogger 0.00023 lb ai/ sq ft

(0.75 oz) Treat evenly using 0.75 oz wettable powder/100 sq ft. Use rotary,

m echanical or electrostatic duster.

Poultry (Fowl Tick)

Spray 0.00080 lb ai/ sq ft (1 gallon) Dilute to a 1.0% solution. Apply 1 gallon solution/100

- 150 sq ft to walls, ceiling, floor cracks, and crevices with power sprayer. Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 lb ai/ sq ft (1 gallon) Dilute to a 2.0% solution. For dry whitewashed wood or concrete block surfaces use 1 gallon of solution/500 sq ft.

0.00016 lb ai/ sq ft (1 gallon) Dilute to a 1.0% solution. For unpainted wood or painted concrete block surfaces, use 1 gallon of solution/500 sq ft.

## Page 51 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

0.000080 lb ai/ sq ft (0.5 gallon) Dilute to a 1.0% solution. For Masonite or galvanized sheet metal surfaces, use 0.5 gallon of solution/ 500 sq ft. Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.0008 lb ai/ sq ft (1 gallon) Dilute to a 1.0% solution. Apply 1 gallon of solution/100 sq ft.

Kennels, Yards, Campgrounds, Picnic Areas, and Recreational Parks 0.000040 lb ai/ sq ft (spot) Dilute to a 0.5% solution. Apply as a spot treatment using a low pressure handwand sprayer only. Apply woody borders.

47000

- 126 Beef Cattle

Spray 0.040 lb ai/gallon

MLA for dusting and paint applications: Baseline clothing, gloves, coveralls, dust mist respirator

All other MLA: Baseline clothing, gloves Dilute to a 0.35

- 0.50% solution. Use a

low pressure coarse spray and apply to point before runoff. Use between 0.5 to 1 gallon of spray solution per animal.

Swine 0.020 lb ai/animal (0.5 gallon ) Dilute to a 0.50% solution. Apply as a coarse spray. Use 0.25 to 0.50 gallon maximum solution per head to treat.

Poultry (Wire Cages) 0.00040 lb ai/ bird (gallon)

0.00031 lb ai/bird (1 oz) Dilute to a 0.50% solution. Apply directly to birds (1 gallon solution/100 birds). For individual bird treatment apply 1 oz of the mixture per bird. Use power sprayer. Poultry (Floor Management

– Litter) Handheld

Fogger, Plunger Duster, Stationary Fogger 0.00078 lb ai/ sq ft Treat evenly and thoroughly using 2.5 oz/100 sq ft. Poultry (Floor Management

- Dusting) 0.0016 lb ai/ bird Apply 2.5 oz wettable powder/50 birds.

Poultry (Floor Management Roost Paint) Paint 0.080 lb ai/ gallon

(1 gallon treats 800 sq ft) Dilute to a 1.0% solution. Treat with brush or spray thoroughly using 1 pint/100 ft.

Poultry (Fowl Tick)

Spray** 0.00080 lb ai/ sq ft (1 gallon) Dilute to a 1.0% solution. Apply 1 gallon solution/100

- 150 sq ft to walls, ceiling, floor cracks, and crevices with power sprayer. Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 lb ai/ sq ft (1 gallon) Dilute to a 2.0% solution. For dry whitewashed wood or concrete block surfaces use 1 gallon of solution/500 sq ft.

0.00016 lb ai/ sq ft (1 gallon) Dilute to a 1.0% solution. For unpainted wood or painted concrete block surfaces, use 1 gallon of solution/500 sq ft.

## Page 52 of 124

Table C .1 . Summary of TCVP Occupational Livestock Use

EPA Reg. No. Use Site Applic. Type/ Equipment Applic. Rate

(lb ai/A) PPE Use Directions and Limitations

0.000080 lb ai/ sq ft (0.5 gallon) Dilute to a 1.0% solution. For Masonite or galvanized sheet metal surfaces, use 0.5 gallon of solution/ 500 sq ft. Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.000080 lb ai/ sq ft (1 gallon) Dilute to a 1.0% solution. Apply 1 gallon of solution/100 sq ft.



### Table C .2 . Summary of TCVP Occupational Pet Products EPA Reg. No. Use Site Application Rate Use Restrictions
Collars

2596

- 49 Cats 1,650 mg ai 11.3 gram collar (14.6% ai) Do not use in kittens under 12 weeks of age.

Place the collar around the cat’s neck, adjust for proper fit, and buckle in place. Leave 2 or 3 inches on the collar for extra adjustment and cut off and dispose of the extra length. Replace the collar every 3 months, every 2 months for severe infestation.

2596

- 50

Dogs 2,770 mg ai 19 gram collar (14.6 % ai)

4,670 mg ai 32 gram collar (14.6% ai) Do not use on puppies less than 6 weeks of age.

Place the collar around the dog’s neck, adjust for pro per fit, and buckle in place. Leave 2 or 3 inches on the collar for extra adjustment and cut off and dispose of the extra length. Replace the collar every 3 months, every 2 months for severe infestation.

2596

- 62 Do not use on puppies less than 12 weeks of age. Place the collar around the dog’s neck, adjust for proper fit, and buckle in place. Leave 2 or 3 inches on the collar for extra adjustment and cut off and dispose of the extra length. Replace the collar every 5 months, every 4 months for severe infestation.

2596

- 63 Cats 2,190 mg ai 15 gram collar (14.6% ai)

2,480 mg ai 17 gram collar (14.6% ai) Do not use on kittens less than 12 weeks of age.

Place the collar around the cat’s neck, adjust for proper fit, and buckle in place. Leave 2 or 3 inches on the collar for extra adjustment and cut off and dispose of the extra length. Replace the collar every 5 months, every 4 months for severe infesta tion.

2596

- 83 Cats 1,750 mg ai 12 gram collar (14.6% ai)

3,650 mg ai 25 gram collar (14.6% ai) Do not use on kittens less than 12 weeks of age.

Place the collar around the cat’s neck, adjust for proper fit, and buckle in place. Leave 2 or 3 inches on the collar for extra adjustment and cut off and dispose of the extra length. Replace the collar every 7 months, every 5 months for severe infestation.

## Page 53 of 124

Table C .2 . Summary of TCVP Occupational Pet Products EPA Reg. No. Use Site Application Rate Use Restrictions

2596

- 84 Dogs 2,770 mg ai 19 gram collar (14.6% ai)

4,670 mg ai 32 gram collar (14.6% ai) Do not use on puppies under 6 weeks of age.

Place the collar around the dog’s neck, adjust for proper fit, and buckle in place. Leave 2 or 3 inches on the collar for extra adjustment and cut off and dispose of the extra length. Replace the collar every 7 months, every 5 months for severe infestation.

2596

- 139 Cats/

Dogs 1,460 mg ai

10 gram collar (14.6% ai)

7,300 mg ai 50 gram collar (14.6% ai) Do not use on puppies under 6 weeks old/ kittens under 12 weeks

old. Place the collar around t he cat’s/dog’s neck, adjust for proper fit, and buckle in place. Leave 2 or 3 inches on the collar for extra adjustment and cut off and dispose of the extra length. Replace the collar every 7 months, or more frequently for severe infestation.

11556

- 16 4 Dogs 3,290 mg ai 24 gram collar (13.7% ai) Do not use on puppies under 6 weeks.

Place the collar around the dog’s neck, adjust for proper fit, and buckle in place. Leave 2 or 3 inches on the collar for extra adjustment and cut off and dispose of the extra length. Replace the collar every 5 months, every 4 months for severe infestation.

11556

- 165 Cats 2,060 mg ai 15 gram collar (13.7% ai) Do not use on kittens less than 12 weeks of age.

Place the collar around the cat’s neck, adjust for proper fit, and buckle in place. Leave 2 or 3 inches on the collar for extra adjustment and cut off and dispose of the extra length. Replace the collar every 5 months, every 4 m onths for severe infestation. Dusts/Powders

2596

- 78 Cats 280 mg ai (3.3% ai) 0.30 ounce per small cat

470 mg ai (3.3% ai) 0.5 ounce per large cat Not for use on kittens less than 12 weeks of age. Dust entire cat beginning at head and working back. Use approximately 1/3 ounce of powder for a small cat or 1⁄2 ounce for a large cat. Repeat at weekly intervals if necessary.

2596

- 79 Dogs 470 mg ai (3.3% ai) 1⁄2 ounce per small dog

940 mg ai 1 ounce per medium dog

1,200 mg ai 1 1⁄4 ounce per large dog Not for use on puppies less than 12 weeks of age. Dust entire dog beginning at the head and working back. Make sure powder gets down to the skin. Lightly dust the dog’s bedding with approximately the same amount of powder. Repeat treatment of dog and bedding at weekly intervals if necessary. Use 1⁄2 ounce of powder for a small dog; 1 oz for a medium dog; and 1 1⁄4 oz for large dogs.

47000

- 123 Cats Estimated Range: 4 3 mg ai, small 100 mg ai, medium 150 mg ai , large (1.0% ai) Do not apply to kittens or puppies under 12 weeks old.

Dust powder evenly over the animal and rub thoroughly through the hair coat to skin. Use 1/3 oz of powder per every 10 pounds of body weight of your cat or dog. Do not reapply product for 30 days.

*PPE: Baseline clothing, c overalls, gloves and dust mist respirator. Dogs Estimated Range:

170 mg ai, small 430 mg ai, medium

## Page 54 of 124

Table C .2 . Summary of TCVP Occupational Pet Products EPA Reg. No. Use Site Application Rate Use Restrictions

680 mg ai, large

67517

- 82 Cats Estimated Range: 130 mg ai, small 310 mg ai, medium 460 mg ai, large (3% ai) Do not use on puppies under 12 weeks of age.

Dust powder liberally over the animal and rub thoroughly through hair coat to skin. Use 1/3 oz of powder per every 10 pounds of body weight of your cat or dog. To control fleas, reapply every 16 days. To con trol brown dog ticks, reapply every 7 days. Dogs Estimated Range:

510 mg ai, small 1,300 mg ai, medium 2,000 mg ai, large Pump/Trigger Sprays

2596

- 125 Dogs 300 mg ai , small 400 mg ai, medium 700 mg ai, large (1.1% ai) Do not apply to pets (puppies) less than 6 weeks old.

Hold bottle upright about 6 inches from pet. Spray lightly until the tips of the pet’s hair are moist. Rub spray into animal’s coat. Repeat once per week. Recommended dosage: Spray 25

- 30 strokes f or a small dog. Spray 30

- 40 strokes for a medium dog. Spray 40

- 70 strokes for a large dog. More spray may be needed for longhaired dogs. 1



### 2596

- 126 Cats 250 mg ai , small 350 mg ai, large (1.1% ai) Do not apply to pets (kittens) less than 6 weeks old.

Hold bottle upright about 6 inches from pet. Spray lightly until the tips of the pet’s hair are moist. Rub spray into animal’s coat. Repeat once per week. Recommended dosage: Spray 15

- 25 strokes f or a small cat. Spray 25

- 35 strokes for a large cat. More spray may be needed for longhaired cats. 1



### 2596

- 140 Cats 3



### (Pump) 51 mg ai , small

71 mg ai, large (1.1% ai) Do not use on puppies or kittens less than 12 weeks old.

Hold bottle upright about 6 i nches from pet. Spray lightly until the tips of the pet’s hair are moist. Rub spray into animal’s coat. Repeat once per week. Recommended dosage: Spray 15

- 25 strokes for a small cat. Spray 25

- 35 strokes for a large cat. 2 

### Recommended dosage: Spray 25

- 35 strokes for a small dog. Spray 30

- 40 strokes for a medium dog. Spray 40

- 70 strokes for a large dog. 2 

### Cats 3 

### (Trigger) 250 mg ai, small

350 mg ai, large (1.1% ai)

Dogs (Trigger) 350 mg ai, small

400 mg ai, medium 700 mg ai, large (1.1% ai)

2596

- 136 A “Cancellation Order for Section 3 Pesticide Product Registration(s)” was finalized on July 31, 2013

pertaining to EPA Reg. No. 2596

- 136, Hartz 2 in 1 Flea and Tick Spray for Cats and Dogs.

2596

- 122,

- 123 EPA Reg. Nos. 2596

- 122 and

- 123 have been voluntarily cancelled.

## Page 55 of 124

Appendix D: Summary of Occupational and Residential Non

- cancer Algorithms

Residential Dermal and Inhalation Handler Exposure Algorithm

Daily dermal and inhalation exposure (mg/day) for residential pesticide handlers, for a given formulation

- application method combination, is estimated by multiplying the formulation

application method

- specific unit exposure by an estimate of the amount of active ingredient handled in a day, u sing the equation below:

E = UE * AR * A

where:

E = exposure (mg/day); UE = unit exposure (mg/lb ai); AR = application rate (e.g., lb ai/ft 2 

## , lb ai/gal); and A = number of animals treated per day.

Residential Post

- application Dermal Exposure Algorithm

The following method is used to calculate dermal exposures that are attributable to an adult or child contacting a treated companion pet:

E = TC * TR * ET

where:

E = exposure (mg/day); TC = transfer coefficient (cm 2 

## /hr); TR = transferable residue (mg/cm 2 

## ); and ET = exposure time (hours/day).

TR = AR ∗ F AR

SA



## where:

TR = transferable residue (mg/cm 2 

## ); AR = application rate or amount applied to animal (mg); F AR 

## = fraction of the application rate available as transferable residue; and SA = surface area of the pet (cm 2 

## ).

## Page 56 of 124

Absorbed dermal dose, normalized to body weight, is calculated as:

D = E * AF BW

where: D = dose (mg/kg

- day); E = exposure (mg/day); AF = absorption factor (dermal); and BW = body weight (kg).

Table D .1. Treated Pets

– Inputs for Residential Post

- application Dermal Exposure Algorithm Notation Exposure Factor Units Point Estimates

AR Application rate (mg) Unique for each product

SA Surface Area of

Animal (cm 2 

### ) Small Cat, Dog Cat

– 1,500 Dog

– 3,000 Medium Cat, Dog Cat

– 2,500 Dog

– 7,000
Large Cat, Dog Cat

– 4,000 Dog

– 11,000

F AR 

### Fracti on of AR Available for Transfer

(recommended point estimate) Non

- Cancer Collar ( Amitraz ): 0.00 14 Davis (Amitraz): 0.0040 Dust/Powder (TCVP): 0.00048 Pump Spray (TCVP): 0.0081

Cancer Collar ( Amitraz): 0.00047 Dust/Powder (TCVP): 0.00022 Pump Spray (TCVP): 0.0018

TC Transfer Coefficient

– Liquids (cm 2 

### /hr) Adult 5,200

Children 1 < 2 years old 1,400

Transfer Coefficient

– Solids (cm 2 

### /hr) Adult 140,000

Children 1 < 2 years old 38,000

ET Exposure Time

(hours per day) Adult 0.77

Children 1 < 2 years old 1.0

BW Body weight

(kg) Adult 80

Children 1 < 2 years old 11

## Page 57 of 124

Residential Post

- application Hand

- to

- Mouth Exposure Algorithm

Exposure from hand

- to

- mouth activity is calculated as follows (based on algorithm utilized in SHEDS

- Multimedia):

E = [HR * (F

M 

## * SA H 

## ) * (ET * N_Replen) * (1

- (1

- SE) (Freq_HtM/N

- Replen) 

## )]

where:

E = exposure (mg/day); HR = hand residue loading (mg/cm 2 

## ); SA H 

## = surface area of one child hand (cm 2 

## ); F M 

## = fraction hand surface area mouthed /event (fraction/event); ET = exposure time (hr/day); N_Replen = number of replenishment intervals per hour (intervals/hour); SE = saliva extraction factor (i.e., mouthing removal efficiency); and Freq_HtM = number of hand

- to

- mouth contacts events per hour (events/hour).

and

HR = E * Fai hands 

## 2 * SA H 

## where: HR = hand residue loading (mg/cm 2 

## ); E = dermal exposure (mg); Fai hands 

## = fraction of a.i. on hands compared to total residue from dermal transfer

coefficient study (unitless); and SA H 

## = surface area of one child hand (cm 2 

## ).

Oral dose, normalized to body weight, is calculated as:

D = E BW where: D = dose (mg/kg

- day); E = exposure (mg/day) ; and BW = body weight (kg).

Table D .2. Treated Pets

– Inputs for Residential Post

- application Hand

- to

- Mouth Exposure Algorithm Notation Exposure Factor (units) Point Estimate(s)

Fai hands 

### Fraction of a.i. on hands from transfer coefficient studies (unitless) Solid = 0.37 Liquid = 0.040

## Page 58 of 124

Table D .2. Treated Pets

– Inputs for Residential Post

- application Hand

- to

- Mouth Exposure Algorithm Notation Exposure Factor (units) Point Estimate(s)

F M 

### Fraction hand surface area mouthed /event (fraction/event) 0.13

N_Replen Replenishment intervals per hour (intervals/hr) 4

ET Exposure time

(hours/day) Children 1 < 2 years old 1.0

SE Saliva extraction factor 0.48

Freq_HtM Hand

- to

- mouth events per hour (events/hr) Children 1 < 2 years old 20

SA H 

### Typical surface area of

one child hand (cm 2 

### ) Children 1 < 2 years old 150

BW Body Weight (kg) Children 1 < 2 years old 11



## Occupational Non

- cancer Handler Algorithms
Potential daily exposures for occupational handlers are calculated using the following formulas:

E=UE * AR * A * 0.001 mg/ug

where:

E = exposure (mg ai/day), UE = unit exposure (μg ai/lb ai), AR = maximum application rate according to proposed label (lb ai A or lb ai/gal), and A = area treated or amount handled (e.g., A/day, gal/day).
The daily doses are calculated using the following formula:

ADD= E * AF BW

where:

ADD = average daily dose absorbed in a given scenario (mg ai/kg/day), E = exposure (mg ai/day), AF = absorption factor (dermal and/or inhalation), and BW = body weight (kg).

Margin of Exposure: Non

- cancer risk estimates for each application handler scenario are calculated using a Margin of Exposure (MOE), wh ich is a ratio of the toxicological endpoint to the daily dose of concern. The daily dermal and inhalation dose received by occupational

## Page 59 of 124

handlers are compared to the appropriate POD (i.e., NOAEL) to assess the risk to occupational handlers for each exposu re route. All MOE values are calculated using the following formula:

MOE= POD ADD

where:

MOE = margin of exposure: value used by HED to represent risk estimates (unitless), POD = point of departure (mg/kg/day), and ADD = average daily dose absorbed in a given scenario (mg ai/kg/day).

Occupational and Residential Cancer Algorithms
After the development of the ADD values, the next step required to calculate carcinogenic risk estimates is to amortize these values over the anticipated lifetime, which results in the LADD. LADD values are calculated using the following equation:

LADD = ADD * Days per Year of Exposure

365 Days per Year * Years per Lifetime of Exposure Lifetime Expectancy

where:

LADD = absorbed dose over a lifetime (mg ai/kg/day), ADD = average daily dose absorbed in a given scenario (mg ai/kg/day), Days per Year of Exposure = annual frequency of an application by an individual (days/year), Years per Lifetime of Exposure = amount of a lifetime that an individual would be expec ted to use pesticides (years), and Lifetime Expectancy = average life expectancy of an individual (years).
Cancer risk estimate calculations are completed by comparing the LADD values calculated above to the Q 1 

## * for the chemical. Cancer risk estimates a re calculated using the following equation:

Total Cancer Risk Estimate = ( Dermal LADD + Inhalation LADD ) * Q 1 

## *

where:



## Cancer Risk Estimate = probability of incidence of cancer cases over a lifetime (unitless), Dermal LADD = absorbed dose from dermal exposure over a lifetime (mg ai/kg/day), Inhalation LADD = absorbed dose from inhalation exposure over a lifetime (mg ai/kg/day), and

## Page 60 of 124

Q 1 

## * = quantitative dose response factor used for linear, low

- dose response cancer risk estimate calculations (mg/kg/day)

- 1



## .

Table D .3. Treated Pets

– Inputs for Cancer Exposure/Risk Algorithm Notation Exposure Factor (units) Point Estimate(s)

EF Exposure Frequency (days/year) Occupational: Private/Farmer

– 10 days/year Contract/Commercial

– 30 days/year Residential : Handlers

- Collars, 4 Dusts/Powders and Pump/Trigger Sprays, 6

Post

- application (all formulations)

- 180

ET Exposure Time (years) 35: occupational 50 : residential AT Averaging Time (years) 78 CF Conversion Factor (days/year) 365

## Page 61 of 124

Appendix E

– Summary of Residential Handler Exposures and Risks

Table E. 1. Residential Handler Non

- cancer Exposure and Risk Estimat es from Use of TCVP Pet Collar Products. No dermal hazard.

Exposure Scenario Reg. No. Level of Concern Dermal Unit

Exposure (mg/lb ai) Inhalation

Unit Exposure (mg/lb ai) Maximum

Application Rate 1 

### (lb ai/pet) Amount

Handled Daily 2 

### Dermal Inhalation

Dose (mg/kg/day) 3 

### MOE 4 

### Dose (mg/kg/day) 5 

### MOE 6



### Use of Spot

- On Exposure Data

- 2012 Residential SOPs

Application of TCVP Collars 2596

- 49:

Cat

NA 120 Negligible 0.0036: 11 gram collar

2

animals treated per day 0.0012

N A, No Dermal Hazard Negligible 2596

- 50, 62:
Dog 0.0061: 19 gram collar 0.0020

0.010: 32 gram collar 0.0034

2596

- 63:

Cat 0.0048: 15 gram collar 0.0016

0.0055: 17 gram collar 0.0018

2596

- 83:

Cat 0.0039: 12 gram collar 0.0013

0.0080: 25 gram collar 0.0027

2596

- 84:
Dog 0.0061: 19 gram collar 0.0021

0.010: 32 gram collar 0.0034

2596

- 139:

Cat 0.0032: 10 gram collar 0.0011

## Page 62 of 124

Table E. 1. Residential Handler Non

- cancer Exposure and Risk Estimat es from Use of TCVP Pet Collar Products. No dermal hazard.

Exposure Scenario Reg. No. Level of Concern Dermal Unit

Exposure (mg/lb ai) Inhalation

Unit Exposure (mg/lb ai) Maximum

Application Rate 1 

### (lb ai/pet) Amount

Handled Daily 2 

### Dermal Inhalation

Dose (mg/kg/day) 3 

### MOE 4 

### Dose (mg/kg/day) 5 

### MOE 6



### 2596

- 139:
Dog 0.016: 50 gram collar 0.0054

11556

- 164:
Dog 0.0072: 24 gram collar 0.0024

11556

- 165:

Cat 0.0045: 15 gram collar 0.0015

Use of TCVP Dust Applicator Exposure Data

Application of TCVP Collars 2596

- 49:

Cat

Inhalation;

300 1,700 3.1 0.0036: 11 gram collar

2

animals treated per day 0.017

N/A, No Dermal Hazard 0.00033 4
, 900

2596

- 50, 62:
Dog 0.0061: 19 gram collar 0.029 0.00055 2
, 900

0.010: 32 gram collar 0.049 0.00092 1
, 700

2596

- 63:

Cat 0.0048: 15 gram collar 0.023 0.00043 3
, 700

0.0055: 17 gram collar 0.026 0.00049 3
, 300

2596

- 83:

Cat 0.0039: 12 gram collar 0.018 0.00035 4
, 600

0.0080: 0.038 0.00072 2
, 200

## Page 63 of 124

Table E. 1. Residential Handler Non

- cancer Exposure and Risk Estimat es from Use of TCVP Pet Collar Products. No dermal hazard.

Exposure Scenario Reg. No. Level of Concern Dermal Unit

Exposure (mg/lb ai) Inhalation

Unit Exposure (mg/lb ai) Maximum

Application Rate 1 

### (lb ai/pet) Amount

Handled Daily 2 

### Dermal Inhalation

Dose (mg/kg/day) 3 

### MOE 4 

### Dose (mg/kg/day) 5 

### MOE 6



### 25 gram collar

2596

- 84:
Dog 0.0061: 19 gram collar 0.029 0.00055 2
, 900

0.010: 32 gram collar 0.049 0.00092 1
, 700

2596

- 139:

Cat 0.0032: 10 gram collar 0.015 0.00029 5
, 500

2596

- 139:
Dog 0.016: 50 gram collar 0.076 0.00144 1
, 100

11556

- 164:
Dog 0.0072: 24 gram collar 0.034 0.00065 2
, 500

11556

- 165:

Cat 0.0045: 15 gram collar 0.021 0.00041 3
, 900

1 Based on registered TCVP pet product labels. 2 Based on HED’s 2012 Residential SOPs ( http://www2.epa.gov/pesticide

- science

- and

- assessing

- pesticide

- risks/standard

- operating

- procedures

- residential

- pesticide ). 3 Dermal Dose = Dermal Unit Exposure (mg/lb ai) × Application Rate (lb ai/pet) × Area Treated or Amount Handled (pets/day) × De rmal Absorption Factor (9.6 %) ÷ Body Weight (69 kg). Dermal dose presented only for purpose of calculation of cancer risks for re sidential handlers. 4 No dermal MOE estimated due to lack of dermal hazard. 5 Inhalation Dose = Inhalation Unit Exposure (mg/lb ai) × Application Rate (lb ai/pet) × Area Treated or Amount Hand led (pets/day) ÷ Body Weight (69 kg). 6 Inhalation MOE = Inha lation NOAEL ( 1.59 mg/kg/day) ÷ Inhalation Dose (mg/kg/day).

## Page 64 of 124

Table E. 2. Residential Handler Non

- cancer Exposure and Risk Estimat es from Use of TCVP Dust/Powder and Pump/Trigger Spray Products. Inhalation LOC is an MOE = 300 ; No dermal hazard.

Exposure Scenario Reg. No. Level of Concern Dermal Unit

Exposure (mg/lb ai) Inhalation

Unit Exposure (mg/lb ai) Maximum

Application Rate 1 

### (lb ai/pet) Amount

Handled Daily 2 

### Dermal Inhalation

Dose (mg/kg/day) 3 

### MOE 4 

### Dose (mg/kg/day) 5 

### MOE 6



### Application of TCVP Dusts/Powders 47000

- 123:

Dog

Inhalation:

300 1,700 3.1 0.00037 :

small

2

animals treated per day 0.0018

N/A, No Dermal Hazard 0.000034 47
, 000

0.00094 :

medium 0.0044 0.000084 19
, 000

0.0015 : large 0.0071 0.00013 12
, 000

47000

- 123: Cat 0.000 0 94:

small 0.00044 0.0000084 190
, 000

0.00023 :

medium 0.0011 0.000020 79
, 000

0.00034 : large 0.0016 0.000030 53
, 000

2596

- 78: Cat 0.00062:

small 0.0029 0.000056 29
, 000

0.0010 : large 0.0049 0.000093 17
, 000

2596

- 79; Dog 0.0010:

small 0.0049 0.000093 17
, 000

## Page 65 of 124

Table E. 2. Residential Handler Non

- cancer Exposure and Risk Estimat es from Use of TCVP Dust/Powder and Pump/Trigger Spray Products. Inhalation LOC is an MOE = 300 ; No dermal hazard.

Exposure Scenario Reg. No. Level of Concern Dermal Unit

Exposure (mg/lb ai) Inhalation

Unit Exposure (mg/lb ai) Maximum

Application Rate 1 

### (lb ai/pet) Amount

Handled Daily 2 

### Dermal Inhalation

Dose (mg/kg/day) 3 

### MOE 4 

### Dose (mg/kg/day) 5 

### MOE 6



### 0.0021:

medium 0.0097 0.00019 8
, 600

0.0026:
large 0.0122 0.00023 6
, 900

67517

- 82: Dog 0.0011 :

small 0.0053 0.00011 16
, 000

0.0028 :

medium 0.013 0.00025 6
, 300

0.0045 : large 0.021 0.00040 3
, 900

67517

- 82: Cat 0.00028 :

small 0.0013 0.000025 63
, 000

0.00067 :

medium 0.0032 0.000061 26
, 000

0.0010 : large 0.0048 0.000091 18
, 000

Application of TCVP Pump /Trigger Sprays 2596

- 126,

- 140: 820 3.3 0.00055: small 0.0013 N/A, No Dermal Hazard 0.000053 30
, 000

0.00077: 0.0018 0.000074 22
, 000

## Page 66 of 124

Table E. 2. Residential Handler Non

- cancer Exposure and Risk Estimat es from Use of TCVP Dust/Powder and Pump/Trigger Spray Products. Inhalation LOC is an MOE = 300 ; No dermal hazard.

Exposure Scenario Reg. No. Level of Concern Dermal Unit

Exposure (mg/lb ai) Inhalation

Unit Exposure (mg/lb ai) Maximum

Application Rate 1 

### (lb ai/pet) Amount

Handled Daily 2 

### Dermal Inhalation

Dose (mg/kg/day) 3 

### MOE 4 

### Dose (mg/kg/day) 5 

### MOE 6



### Cat (Trigger) medium

2596

- 140 Cat (Pump) 0.00011: small 0.00026 0.000011 150
, 000

0.00016: large 0.00036 0.000015 110
, 000

2596

- 125
, - 140 : Dog (Trigger) 0.00077: small 0.0018 0.000074 22
, 000

0.00088: medium 0.0020 0.000084 19
, 000

0.0015: large 0.0035 0.00015 11
, 000

1 Based on registered TCVP pet product labels. 2 Based on HED’s 2012 Residential SOPs ( http://www2.epa.gov/pesticide

- science

- and

- assessing

- pesticide

- risks/standard

- operating

- procedures

- residential

- pesticide ) 3 Dermal Dose = Dermal Unit Exposure (mg/lb ai) × Application Rate (lb ai/pet) × Area Treated or Amount Handled (pets/day) × De rmal Abs orption Factor (9.6 %) ÷ Body Weight (69 kg). Dermal dose presented only for purpose of calculation of cancer risks for residential handlers. 4 No dermal MOE estimated due to lack of dermal hazard. 5 Inhalation Dose = Inhalation Unit Exposure (mg/lb ai ) × Application Rate (lb ai/pet) × Area Treated or Amount Hand led (pets/day) ÷ Body Weight (69 kg). 6 Inhalation MOE = Inhalation NOAEL ( 1.59 mg/kg/day) ÷ Inhalation Dose (mg/kg/day).

## Page 67 of 124

Appendix F

– Summary of Residential Handler Cancer Exposu re and Risk Estimates

Table F. 1. Residential Handler Cancer Exposure and Risk Estimates from TCVP Pet Collar Products Reg No./ Animal Type Animal Size Lifestage LADD 1,2 

### Cancer Risk Estimate 3



### Pet Collars

- Spot

- On Exposure Data (2012 Residential SOPs)
2596

- 49: Cat Any

Adult 8.5E

- 06 1.6E

- 08

2596

- 50, 62: Dog Small 1.4E

- 05 2.6E

- 08 Medium, Large 2.4E

- 05 4.4E

- 08

2596

- 63: Cat Small 1.1E

- 05 2.1E

- 08

Medium, Large 1.3E

- 05 2.3E

- 08

2596

- 83: Cat Small 9.0E

- 06 1.7E

- 08

Medium, Large 1.9E

- 05 3.4E

- 08

2596

- 84: Dog Small 1.4E

- 05 2.6E

- 08

Medium, Large 2.4E

- 05 4.4E

- 08
2596

- 139: Cat Any 7.5E

- 06 1.4E

- 08
2596

- 139: Dog Any 3.8E

- 05 6.9E

- 08 11556

- 164: Dog Any 1.7E

- 05 3.1E

- 08 11556

- 165: Cat Any 1.1E

- 05 1.9E

- 08
Pet Collars

- TCVP Dust Applicator Exposure Data
2596

- 49: Cat Any

Adult 1.2E

- 04 2.2E

- 07

2596

- 50, 62: Dog Small 2.1E

- 04 3.8E

- 07 Medium, Large 3.5E

- 04 6.4E

- 07

2596

- 63: Cat Small 1.6E

- 04 3.0E

- 07

Medium, Large 1.8E

- 04 3.4E

- 07

2596

- 83: Cat Small 1.3E

- 04 2.4E

- 07

Medium, Large 2.7E

- 04 5.0E

- 07

2596

- 84: Dog Small 2.1E

- 04 3.8E

- 07

Medium, Large 3.5E

- 04 6.4E

- 07
2596

- 139: Cat Any 1.1E

- 04 2.0E

- 07
2596

- 139: Dog Any 5.4E

- 04 9.9E

- 07
11556

- 164: Dog Any 2.4E

- 04 4.5E

- 07

11556

- 165: Cat Any 1.5E

- 04 2.8E

- 07

1 Total L ifetime A verage D aily D ose (mg/kg/day) = Dermal LADD (mg/kg/day) + Inhalation LADD (mg/kg/day). 2 Dermal and Inhalation LADD equations provided in Appendix A. 3 Cancer risk estimates = Total LADD × Q 1 * , where Q 1 * = 1.83 x 10

- 3 (mg/kg/day)

- 1

## Page 68 of 124

Table F.2. Residential Handler Cancer Exposure and Risk Estimates from TCVP Pet Products Reg No./ Animal Type Animal Size Lifestage LADD 1,2 

### Cancer Risk Estimate 3


### Dust/Powder

47000

- 123: Dog Small

Adult 1.9E

- 05 3.5E

- 08
Medium 4.7E

- 05 8.7E

- 08 Large 7.6E

- 05 1.4E

- 07

47000

- 123: Cat Small 4.7E

- 06 8.7E

- 09
Medium 1.1E

- 05 2.1E

- 08 Large 1.7E

- 05 3.1E

- 08

2596

- 78: Cat Small 3.1E

- 05 5.7E

- 08
Medium 5.2E

- 05 9.6E

- 08

2596

- 79: Dog Small 5.2E

- 05 9.6E

- 08
Medium 1.0E

- 04 1.9E

- 07 Large 1.3E

- 04 2.4E

- 07

67517

- 82: Dog Small 5.7E

- 05 1.0E

- 07
Medium 1.4E

- 04 2.6E

- 07 Large 2.3E

- 04 4.2E

- 07

67517

- 82: Cat Small 1.4E

- 05 2.6E

- 08
Medium 3.4E

- 05 6.2E

- 08 Large 5.1E

- 05 9.4E

- 08 

### Pump/Trigger Sprays

2596

- 126:

- 140: Cat (Trigger) Small

Adult 1.4E

- 05 2.5E

- 08
Large 1.9E

- 05 3.5E

- 08

2596

- 140: Cat (Pump) Small 2.8E

- 06 5.1E

- 09
Large 3.9E

- 06 7.2E

- 09

2596

- 125,

- 140: Dog (Trigger) Small 1.9E

- 05 3.5E

- 08 Medium 2.2E

- 05 4.0E

- 08 Large 3.9E

- 05 7.0E

- 08 1 Total L ifetime A verage D aily D ose (mg/kg/day) = Dermal LADD (mg/kg/day) + Inhalation LADD (mg/kg/day). 2 Dermal and Inhalation LADD equations provided in Appendix A. 3 Cancer risk estimates = Total LADD × Q 1 * , where Q 1 * = 1.83 x 10

- 3 (mg/kg/day)

- 1

## Page 69 of 124

Appendix G

– Summary of Residential Post

- Application Non

- Cancer Exposure and Risk Estimates

Table G.1. Residential Post

- Application Non

- Cancer Exposu re and Risk Estimates from TCVP Pet Collars (Liquid Formulation). Incidental Oral LOC is an MOE = 1 ,000. EPA Reg. No./ Animal Lifestage Post

- application

Exposure Scenario Application Rate (mg ai) 1 

### Animal

Size Dose (mg/kg/day) 2 

### MOEs 3 

### Route of Exposure Amitraz Exposure Data (MRID 49468801)

2596

- 49: Cat Adult Dermal

1
, 650 Small 0.0 086 X Medium 0.0 051 X Large 0.0 032 X

Children 1 < 2 Dermal Small 0.019 X

Incidental Oral 0.0020 4,100 Dermal Medium 0.011 X Incidental Oral 0.0012 6,800 Dermal Large 0.0 070 X Incidental Oral 0.00074 11 ,000

2596

- 50, 62: Dog Adult Dermal 2
, 77 0 Small 0.0 072 X 4
, 67 0 Large 0.0 033 X

Children 1 < 2 Dermal 2
, 77 0 Small 0. 0 16 X

Incidental Oral 0.0016 4,900 Dermal 4
, 67 0 Large 0.0 072 X Incidental Oral 0.00076 11 ,000

2596

- 83: Cat Adult Dermal 1
, 75 0 Small 0.0 091 X 3
, 650 Large 0.0 071 X

Children 1 < 2 Dermal 1
, 75 0 Small 0. 020 X

Incidental Oral 0.0021 3,800 Dermal 3
, 650 Large 0. 0 16 X Incidental Oral 0.0016 4,900

2596

- 139: Cat Adult Dermal

1
, 460 Small 0.0 076 X Medium 0.0 045 X Large 0.0028 X

Children 1 < 2 Dermal Small 0.017 X

Incidental Oral 0.0017 4,600 Dermal Medium 0. 0 10 X Incidental Oral 0.0010 7,700 Dermal Large 0.0 062 X Incidental Oral 0.00065 12, 000

11556

- 164: Dog Adult Dermal

3,290 Small 0.0 085 X Medium 0.0 037 X Large 0.0 023 X

Children 1 < 2 Dermal Small 0. 0 20 X

Incidental Oral 0.0019 4,100 Dermal Medium 0.0 080 X Incidental Oral 0.00084 9,600 Dermal Large 0.0 051 X

## Page 70 of 124

Table G.1. Residential Post

- Application Non

- Cancer Exposu re and Risk Estimates from TCVP Pet Collars (Liquid Formulation). Incidental Oral LOC is an MOE = 1 ,000. EPA Reg. No./ Animal Lifestage Post

- application

Exposure Scenario Application Rate (mg ai) 1 

### Animal

Size Dose (mg/kg/day) 2 

### MOEs 3 

### Route of Exposure Incidental Oral 0.00053 15,0 00

11556

- 165: Cat Adult Dermal

2,060 Small 0. 0 11 X Medium 0.0 064 X Large 0.0 040 X

Children 1 < 2 Dermal Small 0. 023 X

Incidental Oral 0.0024 3 ,300 Dermal Medium 0.014 X Incidental Oral 0.0015 5,5 00 Dermal Large 0.0088 X Incidental Oral 0.00092 8,7 00

2596

- 84: Dog Adult Dermal 2
, 77 0 Small 0.0 072 X 4
, 67 0 Large 0.0 033 X

Children 1 < 2 Dermal 2
, 77 0 Small 0. 0 16 X

Incidental Oral 0.0016 4,900 Dermal 4
, 67 0 Large 0.0 072 X Incidental Oral 0.00076 11 ,000

2596

- 139: Dog Adult Dermal

7
, 300 Small 0. 019 X Medium 0.0 081 X Large 0.0 052 X

Children 1 < 2 Dermal Small 0. 041 X

Incidental Oral 0.0043 1,800 Dermal Medium 0. 018 X Incidental Oral 0.0019 4,300 Dermal Large 0. 011 X Incidental Oral 0.0012 6,800

2596

- 63: Cat Adult Dermal 2
, 190 Small 0. 011 X
2
, 48 0 Large 0.0048 X

Children 1 < 2 Dermal 2
, 190 Small 0. 025 X

Incidental Oral 0.0026 3 ,100
Dermal 2
, 48 0 Large 0.011 X Incidental Oral 0.0011 7,200 1 Based on registered TCVP pet products as detailed in Table 4.0. 2 Dose (mg/kg/day) equations provided in Appendix A. 3 MOE = Incidental Oral PoD (8.0 mg/kg/day) ÷ Dose (mg/kg/day).

## Page 71 of 124

Table G. 2. Residential Post

- Application Non

- Cancer Exposure and Risk Estimates from TCVP P et Collars (Liquid Formulation). I ncidental Oral LOC is an MOE = 1 ,000. EPA Reg. No./ Animal Lifestage Post

- application

Exposure Scenario Application Rate (mg ai) 1 

### Animal

Size Dose (mg/kg/day) 2 

### MOEs 3 

### Route of Exposure

Davis, M., et al (2008)

2596

- 49: Cat Adult Dermal

1
, 650 Small 0. 024 X Medium 0. 0 15 X Large 0.0 091 X

Children 1 < 2 Dermal Small 0. 053 X

Incidental Oral 0.0056 1,400 Dermal Medium 0. 032 X Incidental Oral 0.0033 2,400 Dermal Large 0. 020 X Incidental Oral 0.0021 3,800

2596

- 50, 62: Dog Adult Dermal 2
, 77 0 Small 0. 020 X 4
, 67 0 Large 0.0 094 X

Children 1 < 2 Dermal 2
, 77 0 Small 0. 045 X

Incidental Oral 0.0047 1,700 Dermal 4
, 67 0 Large 0. 0 21 X Incidental Oral 0.0021 3,700

2596

- 83: Cat Adult Dermal 1
, 75 0 Small 0. 026 X 3
, 650 Large 0. 020 X

Children 1 < 2 Dermal 1
, 75 0 Small 0. 057 X

Incidental Oral 0.0059 1,400 Dermal 3
, 650 Large 0. 044 X Incidental Oral 0.0046 1,700

2596

- 139: Cat Adult Dermal

1
, 460 Small 0. 0 21 X Medium 0. 0 13 X Large 0.0 081 X

Children 1 < 2 Dermal Small 0. 047 X

Incidental Oral 0.0049 1,600 Dermal Medium 0.028 X Incidental Oral 0.0030 2,700 Dermal Large 0. 0 18 X Incidental Oral 0.0018 4,300

11556

- 164: Dog Adult Dermal

3,290 Small 0. 024 X Medium 0. 010 X Large 0.0066 X

Children 1 < 2 Dermal Small 0. 053 X

Incidental Oral 0.0055 1,400 Dermal Medium 0. 023 X Incidental Oral 0.0024 3,400 Dermal Large 0. 0 15 X Incidental Oral 0.0015 5,300 11556

- 165: Cat Adult Dermal 2,060 Small 0. 030 X Medium 0. 018 X

## Page 72 of 124

Table G. 2. Residential Post

- Application Non

- Cancer Exposure and Risk Estimates from TCVP P et Collars (Liquid Formulation). I ncidental Oral LOC is an MOE = 1 ,000. EPA Reg. No./ Animal Lifestage Post

- application

Exposure Scenario Application Rate (mg ai) 1 

### Animal

Size Dose (mg/kg/day) 2 

### MOEs 3 

### Route of Exposure Large 0. 011 X

Children 1 < 2 Dermal Small 0. 066 X

Incidental Oral 0.0069 1,200 Dermal Medium 0. 040 X Incidental Oral 0.0042 1,900 Dermal Large 0. 025 X Incidental Oral 0.0026 3,100

2596

- 84: Dog Adult Dermal 2
, 77 0 Small 0. 020 X 4
, 67 0 Large 0.0 094 X

Children 1 < 2 Dermal 2
, 77 0 Small 0. 045 X

Incidental Oral 0.0047 1,700 Dermal 4
, 67 0 Large 0. 0 21 X Incidental Oral 0.0021 3,700

2596

- 139: Dog Adult Dermal

7
, 300 Small 0. 054 X Medium 0. 023 X Large 0. 0 15 X

Children 1 < 2 Dermal Small 0.12 X

Incidental Oral 0.012 650 Dermal Medium 0. 050 X Incidental Oral 0.0053 1,500 Dermal Large 0. 032 X Incidental Oral 0.0034 2,400

2596

- 63: Cat Adult Dermal 2
, 190 Small 0. 032 X
2
, 48 0 Large 0. 0 14 X

Children 1 < 2 Dermal 2
, 190 Small 0. 071 X

Incidental Oral 0.0074 1,100
Dermal 2
, 48 0 Large 0. 030 X Incidental Oral 0.0031 2,500 1 Based on registered TCVP pet products as detailed in Table 4.0. 2 Dose (mg/kg/day) equations provided in Appendix A. 3 MOE = Incidental Oral PoD (8.0 mg/kg/day) ÷ Dose (mg/kg/day).

## Page 73 of 124

Table G.3

. Residential Post

- Application Non

- Cancer Exposu re and Risk Estimates from TCVP Pet Collars (Solid Formulation). Incidental Oral LOC is an MOE = 1 ,000. EPA Reg. No./ Animal Lifestage Post

- application

Exposure Scenario Application Rate (mg ai) 1 

### Animal

Size Dose (mg/kg/day) 2 

### MOEs 3 

### Route of Exposure Amitraz Exposure Data (MRID 49468801)

2596

- 49: Cat Adult Dermal

1
, 650 Small 0.23 X Medium 0.14 X Large 0.086 X

Children 1 < 2 Dermal Small 0.51 X

Incidental Oral 0.49 16 Dermal Medium 0.31 X Incidental Oral 0.30 27 Dermal Large 0.19 X Incidental Oral 0.18 43

2596

- 50 and 2596

- 62 : Dog Adult Dermal 2
, 77 0 Small 0.19 X 4
, 67 0 Large 0.089 X

Children 1 < 2 Dermal 2
, 77 0 Small 0.43 X

Incidental Oral 0.41 19 Dermal 4
, 67 0 Large 0.20 X Incidental Oral 0.19 42

2596

- 83: Cat Adult Dermal 1
, 75 0 Small 0.24 X 3
, 650 Large 0.19 X

Children 1 < 2 Dermal 1
, 75 0 Small 0.54 X

Incidental Oral 0.52 15 Dermal 3
, 650 Large 0.42 X Incidental Oral 0.41 20

2596

- 139: Cat Adult Dermal

1
, 460 Small 0.20 X Medium 0.12 X Large 0.076 X

Children 1 < 2 Dermal Small 0.45 X

Incidental Oral 0.44 18 Dermal Medium 0.27 X Incidental Oral 0.26 31 Dermal Large 0.17 X Incidental Oral 0.16 49

11556

- 164: Dog Adult Dermal

3,290 Small 0.23 X Medium 0.098 X Large 0.063 X

Children 1 < 2 Dermal Small 0.51 X

Incidental Oral 0.49 16 Dermal Medium 0.22 X Incidental Oral 0.21 38 Dermal Large 0.14 X Incidental Oral 0.13 60 11556

- 165: Cat Adult Dermal 2,060 Small 0.29 X Medium 0.17 X

## Page 74 of 124

Table G.3

. Residential Post

- Application Non

- Cancer Exposu re and Risk Estimates from TCVP Pet Collars (Solid Formulation). Incidental Oral LOC is an MOE = 1 ,000. EPA Reg. No./ Animal Lifestage Post

- application

Exposure Scenario Application Rate (mg ai) 1 

### Animal

Size Dose (mg/kg/day) 2 

### MOEs 3 

### Route of Exposure Large 0.11 X

Children 1 < 2 Dermal Small 0.63 X

Incidental Oral 0.61 13 Dermal Medium 0.38 X Incidental Oral 0.37 22 Dermal Large 0.24 X Incidental Oral 0.23 35

2596

- 84: Dog Adult Dermal 2
, 77 0 Small 0.19 X 4
, 67 0 Large 0.089 X

Children 1 < 2 Dermal 2
, 77 0 Small 0.43 X

Incidental Oral 0.41 19 Dermal 4
, 67 0 Large 0.20 X Incidental Oral 0.19 42

2596

- 139: Dog Adult Dermal

7
, 300 Small 0.51 X Medium 0.22 X Large 0.14 X

Children 1 < 2 Dermal Small 1.1 X

Incidental Oral 1.1 7.3 Dermal Medium 0.48 X Incidental Oral 0.47 17 Dermal Large 0.31 X Incidental Oral 0.30 27

2596

- 63: Cat Adult Dermal 2
, 190 Small 0.31 X
2
, 48 0 Large 0.13 X

Children 1 < 2 Dermal 2
, 190 Small 0.68 X

Incidental Oral 0.65 12
Dermal 2
, 48 0 Large 0.29 X Incidental Oral 0.28 29 1 Based on registered TCVP pet products as detailed in Table 4.0. 2 Dose (mg/kg/day) equations provided in Appendix A. 3 MOE = Incidental Oral PoD (8.0 mg/kg/day) ÷ Dose (mg/kg/day).

## Page 75 of 124

Table G. 4. Residential Post

- Application Non

- Cancer Exposure and Risk Estimates from TCVP Dust/Powder and Pump/Trigger Spray Formulations

. Incidental Oral LOC is an MOE = 1 ,000. EPA Reg. No./ Animal Lifestage Post

- application Exposure Scenario Application Rate (mg ai) 1 

### Animal

Size Dose (mg/kg/day) 2 

### MOEs 3 

### Route of Exposure

Dusts/Powders

47000

- 123: Dog Adult Dermal 170 Small 0.0041 X 430 Medium 0.0044 X 680 Large 0.0044 X

Children 1 < 2 Dermal 170 Small 0.0090 X

Incidental Oral 0.0087 920 Dermal 430 Medium 0.0096 X Incidental Oral 0.0093 860 Dermal 680 Large 0.0098 X Incidental Oral 0.0095 840

47000

- 123: Cat Adult Dermal 43 Small 0.0020 X 100 Medium 0.0029 X 150 Large 0.0027 X

Children 1 < 2 Dermal 43 Small 0.0045 X

Incidental Oral 0.0043 1,800 Dermal 100 Medium 0.0065 X Incidental Oral 0.0063 1,300 Dermal 150 Large 0.0061 X Incidental Oral 0.0059 1,400

2596

- 78: Cat Adult Dermal 280 Small 0.013 X 470 Large 0.0084 X

Children 1 < 2 Dermal 280 Small 0.030 X

Incidental Oral 0.029 280 Dermal 470 Large 0.019 X Incidental Oral 0.018 450

2596

- 79: Dog Adult Dermal 470 Small 0.011 X 940 Medium 0.0096 X 1,200 Large 0.0076 X

Children 1 < 2 Dermal 470 Small 0.025 X

Incidental Oral 0.024 330 Dermal 940 Medium 0.021 X Incidental Oral 0.021 390 Dermal 1,200 Large 0.017 X Incidental Oral 0.016 490

67517

- 82: Dog Adult Dermal 510 Small 0.012 X 1,300 Medium 0.013 X 2,000 Large 0.013 X

Children 1 < 2 Dermal 510 Small 0.027 X

Incidental Oral 0.026 310 Dermal 1,300 Medium 0.029 X

## Page 76 of 124

Table G. 4. Residential Post

- Application Non

- Cancer Exposure and Risk Estimates from TCVP Dust/Powder and Pump/Trigger Spray Formulations

. Incidental Oral LOC is an MOE = 1 ,000. EPA Reg. No./ Animal Lifestage Post

- application Exposure Scenario Application Rate (mg ai) 1 

### Animal

Size Dose (mg/kg/day) 2 

### MOEs 3 

### Route of Exposure Incidental Oral 0.028 290 Dermal 2,000 Large 0.029 X Incidental Oral 0.028 280

67517

- 82: Cat Adult Dermal 130 Small 0.0061 X 310 Medium 0.0088 X 460 Large 0.0082 X

Children 1 < 2 Dermal 130 Small 0.013 X

Incidental Oral 0.013 610 Dermal 310 Medium 0.019 X Incidental Oral 0.019 430 Dermal 460 Large 0.018 X Incidental Oral 0.018 450

Pump/Trigger Spray

2596

- 126, 140: Cat (Trigger) Adult Dermal 250 Small 0.0075 X 350 Large 0.0039 X

Children 1 < 2 Dermal 250 Small 0.016 X

Incidental Oral 0.0017 4,700 Dermal 350 Large 0.0086 X Incidental Oral 0.00090 8,900

2596

- 140: Cat (Pump) Adult Dermal 51 Small 0.0015 X
71 Large 0.00080 X

Children 1 < 2 Dermal 51 Small 0.0034 X

Incidental Oral 0.00035 23,000
Dermal 71 Large 0.0018 X
Incidental Oral 0.00018 43,000

2596

- 125,

- 140: Dog (Trigger) Adult Dermal 350 Small 0.0052 X 400 Medium 0.0026 X 700 Large 0.0029 X

Children 1 < 2 Dermal 350 Small 0.012 X

Incidental Oral 0.0012 6,600 Dermal 400 Medium 0.0056 X Incidental Oral 0.00059 14,000 Dermal 700 Large 0.0063 X Incidental Oral 0.00066 12,000
1 Based on registered TCVP pet products as detailed in Table 4.0. 2 Dose (mg/kg/day) equations provided in Appendix A. 3 MOE = Incidental Oral PoD (8.0 mg/kg/day) ÷ Dose (mg/kg/day).

## Page 77 of 124

Appendix H

– Summary of Residential Post

- Application Cancer Exposure and Risks

Table H.1 . Residential Post

- Application Cancer Exposure and Risk Estimates from TCVP Pet Collar

- Liquid Formulation

Animal Type Animal Size Lifestage LADD 1,2 

### Cancer Risk Estimate 3



### Amitraz Exposure Data (MRID 49468801)

2596

- 49: Cat Small

Adult 9.1E

- 04 1.7E

- 06
Medium 5.4E

- 04 1.0E

- 06 Large 3.4E

- 04 6.2E

- 07

2596

- 50,62: Dog Small 7.6E

- 04 1.4E

- 06 Large 3.5E

- 04 6.4E

- 07

2596

- 83: Cat Small 9.6E

- 04 1.8E

- 06 Large 7.5E

- 04 1.4E

- 06

2596

- 139: Cat Small 8.0E

- 04 1.5E

- 06
Medium 4.8E

- 04 8.8E

- 07 Large 3.0E

- 04 5.5E

- 07

11556

- 164: Dog Small 9.0E

- 04 1.7E

- 06
Medium 3.9E

- 04 7.1E

- 07 Large 2.5E

- 04 4.5E

- 07

11556

- 165: Cat Small 1.1E

- 03 2.1E

- 06

Medium 6.8E

- 04 1.2E

- 06 Large 4.2E

- 04 7.8E

- 07

2596

- 84: Dog Small 7.6E

- 04 1.4E

- 06 Large 3.5E

- 04 6.4E

- 07

2596

- 139: Dog Small 2.0E

- 03 3.7E

- 06
Medium 8.6E

- 04 1.6E

- 06 Large 5.5E

- 04 1.0E

- 06

2596

- 63: Cat Small 1.2E

- 03 2.2E

- 06 Large 5.1E

- 04 9.4E

- 07 

### Davis, M., et al (2008)

2596

- 49: Cat Small 5.8E

- 03 1.1E

- 05

Medium 3.5E

- 03 6.4E

- 06
Large 2.2E

- 03 4.0E

- 06

2596

- 50,62: Dog Small 4.9E

- 03 8.9E

- 06
Large 2.2E

- 03 4.1E

- 06

2596

- 83: Cat Small 6.2E

- 03 1.1E

- 05

## Page 78 of 124

Table H.1 . Residential Post

- Application Cancer Exposure and Risk Estimates from TCVP Pet Collar

- Liquid Formulation

Animal Type Animal Size Lifestage LADD 1,2 

### Cancer Risk Estimate 3



### Large 4.8E

- 03 8.8E

- 06

2596

- 139: Cat Small 5.1E

- 03 9.4E

- 06

Medium 3.1E

- 03 5.6E

- 06
Large 1.9E

- 03 3.5E

- 06

11556

- 164: Dog Small 5.8E

- 03 1.1E

- 05

Medium 2.5E

- 03 4.5E

- 06
Large 1.6E

- 03 2.9E

- 06

11556

- 165: Cat Small 7.2E

- 03 1.3E

- 05

Medium 4.3E

- 03 7.9E

- 06
Large 2.7E

- 03 5.0E

- 06

2596

- 84: Dog Small 4.9E

- 03 8.9E

- 06
Large 2.2E

- 03 4.1E

- 06

2596

- 139: Dog Small 1.3E

- 02 2.3E

- 05

Medium 5.5E

- 03 1.0E

- 05
Large 3.5E

- 03 6.4E

- 06

2596

- 63: Cat Small 7.7E

- 03 1.4E

- 05
Large 3.3E

- 03 6.0E

- 06

## Page 7 9 of 124

Table H.2 . Residential Post

- Application Cancer Exposure and Risk Estimates from TCVP Pet Collar

- Solid Formulation

Animal Type Animal Size Lifestage LADD 1,2 

### Cancer Risk Estimate 3



### Amitraz Exposure Data (MRID 49468801)

2596

- 49: Cat Small

Adult 2.4E

- 02 4.5E

- 05
Medium 1.5E

- 02 2.7E

- 05 Large 9.2E

- 03 1.7E

- 05

2596

- 50,62: Dog Small 2.1E

- 02 3.8E

- 05 Large 9.4E

- 03 1.7E

- 05

2596

- 83: Cat Small 2.6E

- 02 4.7E

- 05 Large 2.0E

- 02 3.7E

- 05

2596

- 139: Cat Small 2.2E

- 02 4.0E

- 05
Medium 1.3E

- 02 2.4E

- 05 Large 8.1E

- 03 1.5E

- 05

11556

- 164: Dog Small 2.4E

- 02 4.5E

- 05
Medium 1.0E

- 02 1.9E

- 05 Large 6.6E

- 03 1.2E

- 05

11556

- 165: Cat Small 3.0E

- 02 5.6E

- 05

Medium 1.8E

- 02 3.3E

- 05 Large 1.1E

- 02 2.1E

- 05

2596

- 84: Dog Small 2.1E

- 02 3.8E

- 05 Large 9.4E

- 03 1.7E

- 05

2596

- 139: Dog Small 5.4E

- 02 9.9E

- 05
Medium 2.3E

- 02 4.2E

- 05 Large 1.5E

- 02 2.7E

- 05

2596

- 63: Cat Small 3.2E

- 02 5.9E

- 05 Large 1.4E

- 02 2.5E

- 05

## Page 80 of 124

Table H.3 . Residential Post

- Application Cancer Exposure and Risk Estimates from TCVP Pet Products

Animal Type Animal

Size Lifestage LADD 1,2 

### Cancer Risk Estimate 3



### Dust/Powder

47000

- 123: Dog Small

Adult 5.9E

- 04 1.1E

- 06



### Medium 6.3E

- 04 1.2E

- 06 

### Large 6.4E

- 04 1.2E

- 06



### 47000

- 123: Cat Small 2.9E

- 04 5.4E

- 07



### Medium 4.2E

- 04 7.8E

- 07 

### Large 4.0E

- 04 7.3E

- 07



### 2596

- 78: Cat Small 1.9E

- 03 3.6E

- 06



### Large 1.2E

- 03 2.2E

- 06



### 2596

- 79: Dog Small 1.6E

- 03 3.0E

- 06



### Medium 1.4E

- 03 2.5E

- 06 

### Large 1.1E

- 03 2.0E

- 06



### 67517

- 82: Dog Small 1.8E

- 03 3.2E

- 06



### Medium 1.9E

- 03 3.5E

- 06 

### Large 1.9E

- 03 3.5E

- 06



### 67517

- 82: Cat Small 8.8E

- 04 1.6E

- 06



### Medium 1.3E

- 03 2.3E

- 06 

### Large 1.2E

- 03 2.2E

- 06

Pump/Trigger Spray


### 2596

- 126, 140: Cat (Trigger) Small

Adult 5.3E

- 04 9.6E

- 07



### Large 2.8E

- 04 5.1E

- 07


### 2596

- 140: Cat (Pump) Small 1.1E

- 04 2.0E

- 07



### Large 5.6E

- 05 1.0E

- 07



### 2596

- 125,

- 140: Dog (Trigger) Small 3.7E

- 04 6.7E

- 07



### Medium 1.8E

- 04 3.3E

- 07 

### Large 2.0E

- 04 3.7E

- 07
1 Total Lifetime Average Daily Dose (mg/kg/day) = Dermal LADD (mg/kg/day) + Inhalation LADD (mg/kg/day). 2 Dermal and Inhalation LADD equations provided in Appendix A. 3 Cancer risk estimates = Total LADD × Q1*, where Q1* = 1.83 x 10

- 3 (mg/kg/day)

- 1

## Page 81 of 124

Appendix I

– Summary of Occupational Handler Exposures and Risks

Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates

. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC

Mixer/Loaders

(1a) Mixing/ Loading Liquids for Groundboom Applications Poultry Buildings

(Floors) 0.00077

(lb ai/ sq ft)

100,000

(sq ft/day) 2.5E

- 04 4.9E

- 05 2.5E

- 05 9.3E

- 05 20,000 100,000 200,000 94,000

Poultry Buildings (Floor Management, Fowl Tick) 0.00064 2.0E

- 04 4.1E

- 05 2.0E

- 05 7.7E

- 05 2,5000 120,000 250,000 110,000

Poultry Buildings (Flies Residual) 0.00013 4.1E

- 05 8.3E

- 06 4.1E

- 06 1.6E

- 05 120,000 600,000 1,200,000 550,000 Poultry Floor Management 0.000064 2.0E

- 05 4.1E

- 06 2.0E

- 06 7.7E

- 06 250,000 1,200,000 2,500,000 1,100,000
(1b) Mixing/ Loading Liquids for Paint Applications Poultry Buildings

(Roost) 0.077 2 gallons 4.9E

- 07 9.8E

- 08 4.9E

- 08 1.9E

- 07 1.0E+07 5.1E+07 1.0E+08 4.7E+07

0.064 (lb ai/ gallon) 4.1E

- 07 8.1E

- 08 4.1E

- 08 1.5E

- 07 1.2E+07 6.1E+07 1.2E+08 5.6E+07

(2a) Mixing/ Loading Wettable Powders for Groundboom Applications Poultry Buildings

(Including: Droppings, Floor Management Litter, Fowl Tick) 0.00080

(lb ai/ sq ft) 100,000

sq ft 0.050 0.010 0.0050 0.00028 170 870 1,700 31,000

Dairy Barns, Poultry Houses, Swine Barns, or Other Animal Buildings 0.00032 0.0200 0.040 0.0020 0.00011 430 2,200 4,300 78,000

(2b, 2c) Mixing/ Loading Wettable Powders for Handheld fogger, and Stationary Poultry (Floor

Management

- Litter) 0.0016

(lb ai/ bird) 20,000

birds 0.020 0.0040 0.0020 0.00011 430 2,200 4,300 78,000

0.00078 (lb ai/ sq ft) 100,000

sq ft 0.049 0.0097 0.0049 0.00027 180 890 1,800 32,000

0.00023 0.014 0.0029 0.0014 0.000080 610 3,000 6,100 110,000

## Page 82 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates

. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC Fogger Applications (2d) Mixing/ Loading Wettable Powders for Paint Applications Poultry (Floor

Management

– Roost) 0.080

(lb ai/ gallon)

2 gallons 1.0E

- 04 2.0E

- 05 1.0E

- 05 5.6E

- 07 87,000 430,000 870,000 16,000,000

(3a) Mixing/ Loading Dusts for Paint Applications (WP Data as Surrogate) 0.030 (lb ai/ gallon) 3.7E

- 05 7.5E

- 06 3.7E

- 06 2.1E

- 07 230,000 1,200,000 2,300,000 41,000,000

Applicators

(4) Groundboom Applications Poultry Buildings

(Including: Droppings, Floor Management Litter, Fowl Tick, Garbage Piles, Manure Piles, Under Feed Troughs) 0.00080

(lb ai/ sq ft)

100,000

sq ft 3.9E

- 04 7.9E

- 05 3.9E

- 05 5.0E

- 05 6,300 31,000 63,000 170,000

Poultry Buildings (Including: Ceilings, Floors, Larvicide, Walls) 0.00077 3.8E

- 04 7.6E

- 05 3.8E

- 05 4.8E

- 05 6,500 33,000 65,000 180,000

Poultry Buildings (Including: Floor Management, Fowl Tick, Larvicide) 0.00064 3.2E

- 04 6.3E

- 05 3.2E

- 05 4.0E

- 05 7,800 39,000 78,000 220,000

Dairy Barns, Poultry Houses, Swine Barns, or Other Animal Buildings 0.00032 1.6E

- 04 3.2E

- 05 1.6E

- 05 2.0E

- 05 1,6000 78,000 160,000 430,000

## Page 83 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates

. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC
Poultry Buildings (Flies Residual) 0.00013 6.4E

- 05 1.3E

- 05 6.4E

- 06 8.1E

- 06 39,000 190,000 390,000 1,100,000 Poultry (Floor Management) 0.000064 3.2E

- 05 6.3E

- 06 3.2E

- 06 4.0E

- 06 78,000 390,000 780,000 2,200,000

(5) Open Pour Liquid Additive for Feed Through Applications Cattle Feed

(Concentrate) 0.0039

(lb ai/ animal) 1,000

cows 1.2E

- 05 2.5E

- 06 1.2E

- 06 No Data 400,000 2,000,000 4,000,000 No Data

Cattle Feed (Concentrate) 0.0022 7.0E

- 06 1.4E

- 06 7.0E

- 07 No Data 710,000 3,600,000 7,100,000 No Data

Horse Feed 0.0017 500 horses 2.7E

- 06 5.4E

- 07 2.7E

- 07 No Data 1,800,000 9,300,000 18,000,000 No Data

Swine Feed 0.00060 6,250 pigs 1.2E

- 05 2.4E

- 06 1.2E

- 06 No Data 420,000 2,100,000 4,200,000 No Data

(6 a ) RTU Pet Collar Applications 1

- Liquid Formulation Cat (2596

- 49) 0.0036

8 animals 

### Inhalation exposures for the application of pet collar products are negligible

. Dog (2596

- 50,62)

- Small 0.0061 Dog (2596

- 50,62)

- Large 0.010 Cat (2596

- 63)

- Small 0.0048

Cat (2596

- 63)

- Large 0.0055 Cat (2596

- 83)

- Small 0.0039 Cat (2596

- 83)

- Large 0.0080 Dog (2596

- 84)

– Small 0.0061 Dog (2596

- 84)

– Large 0.010 Cat (2596

- 139)

- All 0.0032 Dog (2596

- 139)

- All 0.016 Dog (11556

- 164)

- All 0.0072

## Page 84 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates

. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC Cat (11556

- 165)

- All 0.0045

(6 b ) RTU Pet Collar Applications

Dust Formulation Cat (2596

- 49) 0.0036 0.504 0.101 0.0504 No Data 680 3400 6800 No Data

Dog (2596

- 50,62)

- Small 0.0061 0.854 0.171 0.0854 No Data 400 2000 4000 No Data

Dog (2596

- 50,62)

- Large 0.010 1.4 0.28 0.14 No Data 250 1200 2500 No Data

Cat (2596

- 63)

- Small 0.0048 0.672 0.134 0.0672 No Data 510 2600 5100 No Data

Cat (2596

- 63)

- Large 0.0055 0.77 0.154 0.077 No Data 450 2200 4500 No Data

Cat (2596

- 83)

- Small 0.0039 0.546 0.109 0.0546 No Data 630 3200 6300 No Data

Cat (2596

- 83)

- Large 0.0080 1.12 0.224 0.112 No Data 310 1500 3100 No Data

Dog (2596

- 84)

– Small 0.0061 0.854 0.171 0.0854 No Data 400 2000 4000 No Data

Dog (2596

- 84)

– Large 0.010 1.4 0.28 0.14 No Data 250 1200 2500 No Data

Cat (2596

- 139)

- All 0.0032 0.448 0.0896 0.0448 No Data 770 3800 7700 No Data

Dog (2596

- 139)

- All 0.016 2.24 0.448 0.224 No Data 150 770 1500 No Data

Dog (11556

- 164)

- All 0.0072 1.01 0.202 0.101 No Data 340 1700 3400 No Data

Cat (11556

- 165)

- All 0.0045 0.63 0.126 0.063 No Data 550 2700 5500 No Data

(7) RTU Dust/Powder Applications Dog (47000

- 123)

-

Small 0.00037 0.00075 0.00015 0.000075 No Data 6,600 33,000 66,000 No Data Dog (47000

- 123)

- Medium 0.00094 0.0019 0.00038 0.00019 No Data 2,600 13,000 26,000 No Data Dog (47000

- 123)

- Large 0.0015 0.0030 0.00061 0.00030 No Data 1,600 8,200 16,000 No Data Cat (47000

- 123)

- Small 0.000090 0.00018 0.000037 0.000018 No Data 27,000 140,000 270,000 No Data Cat (47000

- 123)

- Medium 0.00022 0.00045 0.000089 0.000045 No Data 11,000 56,000 110,000 No Data

## Page 85 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates

. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC Cat (47000

- 123)

- Large 0.00034 0.00069 0.00014 0.000069 No Data 7,200 36,000 72,000 No Data Cat (2596

- 78)

- Small 0.00062 0.0013 0.00025 0.00013 No Data 4,000 20,000 40,000 No Data Cat (2596

- 78)

- Large 0.0010 0.0020 0.00041 0.00020 No Data 2,500 12,000 25,000 No Data Dog (2596

- 79)

- Small 0.0010 0.0020 0.00041 0.00020 No Data 2,500 12,000 25,000 No Data Dog (2596

- 79)

- Medium 0.0021 0.0043 0.00085 0.00043 No Data 1,200 5,900 12,000 No Data Dog (2596

- 79)

- Large 0.0026 0.0053 0.0011 0.00053 No Data 940 4,700 9,400 No Data Dog (67517

- 82)

- Small 0.0011 0.0022 0.00045 0.00022 No Data 2,200 11,000 22,000 No Data Dog (67517

- 82)

- Medium 0.0028 0.0057 0.0011 0.00057 No Data 880 4,400 8,800 No Data Dog (67517

- 82)

- Large 0.0045 0.0091 0.0018 0.00091 No Data 550 2,700 5,500 No Data Cat (67517

- 82)

- Small 0.00028 0.00057 0.00011 0.000057 No Data 8,800 44,000 88,000 No Data Cat (67517

- 82)

- Medium 0.00067 0.0014 0.00027 0.00014 No Data 3,700 18,000 37,000 No Data Cat (67517

- 82)

- Large 0.0010 0.0020 0.00041 0.00020 No Data 2,500 12,000 25,000 No Data

(8) RTU Pump/Trigger Spray Applications Cat (2596

- 126,140)

- Trigger

- Small 0.00055 0.00021 0.000042 0.000021 No Data 24,000 120,000 240,000 No Data Cat (2596

- 126,140)

- Trigger

- Large 0.00077 0.00029 0.000059 0.000029 No Data 17,000 85,000 170,000 No Data Cat (2596

- 140)

- Pump

- Small 0.00011 0.000042 0.0000084 0.0000042 No Data 120,000 590,000 1,200,000 No Data Cat (2596

- 140)

- Pump

- Large 0.00016 0.000061 0.000012 0.0000061 No Data 82,000 410,000 820,000 No Data Dog (2596

- 125,

- 140)

- Small 0.00077 0.00029 0.000059 0.000029 No Data 17,000 85,000 170,000 No Data Dog (2596

- 125,

- 140)

- Medium 0.00088 0.00034 0.000067 0.000034 No Data 15,000 74,000 150,000 No Data Dog (2596

- 125,

- 140)

- Large 0.0015 0.00057 0.00012 0.000057 No Data 8,700 43,000 87,000 No Data

## Page 86 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates

. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC
Mixers/Loaders/Applicators

(9a) Liquid: Backpack Sprayer Beef Cattle

- Direct

Applied 0.039

(lb ai/ animal) 400

animals 0.0068 0.0014 0.00068 No Data 1,300 6,400 13,000 No Data

0.032 0.0056 0.0011 0.00056 No Data 1,600 7,800 16,000 No Data Woody Borders of Kennels, Yards, Campgrounds, Recreational Parks, Footpaths and Roadways 0.032

(lb ai/ sq ft) 1,000

sq ft (spot) 0.014 0.0028 0.0014 No Data 620 3,100 6,200 No Data

Beef Cattle

- Direct Applied 0.026

(lb ai/ animal) 400

animals 0.0045 0.00090 0.00045 No Data 1,900 9,600 19,000 No Data

Swine

- Direct Applied 0.049 0.0085 0.0017 0.00085 No Data 1,000 5,100 10,000 No Data Lactating Dairy Cattle

- Direct Applied 0.0049 0.00085 0.00017 0.000085 No Data 10,000 51,000 100,000 No Data

0.0013 0.00023 0.000045 0.000023 No Data 38,000 190,000 380,000 No Data
Poultry Buildings (Walls, Ceilings, Floors, Larvicide) 0.00077 lb ai/ sq ft 20,000

sq ft 0.0067 0.0013 0.00067 No Data 1,300 6,500 13,000 No Data

Poultry Buildings (Floor Management, Fowl Tick, Larvicide) 0.00064 0.0056 0.0011 0.00056 No Data 1,600 7,800 16,000 No Data

Poultry (Caged)

- Direct Applied 0.00032

lb ai/ bird 20,000

birds 0.0028 0.00056 0.00028 No Data 3,100 16,000 31,000 No Data

Poultry Buildings (Flies Residual)

- 0.00013 20,000 sq ft 0.0011 0.00023 0.00011 No Data 3,300 17,000 33,000 No Data
Poultry (Chicken on Litter)

- Direct Applied 0.000078

lb ai/ bird 20,000

birds 0.00068 0.00014 0.000068 No Data 7,700 38,000 77,000 No Data

Poultry Floor Management 0.000064

lb ai/ 20,000

sq ft 0.00056 0.00011 0.000056 No Data 13,000 64,000 130,000 No Data

## Page 87 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates

. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC
sq ft

(9b) Liquid: Manually

Pressurized Handwand Beef Cattle

- Direct

Applied 0.039

(lb ai/ animal) 400

animals 0.0068 0.0014 0.00068 No Data 1,300 6,400 13,000 No Data

0.032 0.0056 0.0011 0.00056 No Data 1,600 7,800 16,000 No Data Woody Borders of Kennels, Yards, Campgrounds, Recreational Parks, Footpaths and Roadways 0.032

(lb ai/ sq ft) 1,000

sq ft (spot) 0.0139 0.0028 0.0014 No Data 620 3,100 6,200 No Data

Beef Cattle

- Direct Applied 0.026

(lb ai/ animal) 400

animals 0.0045 0.00090 0.00045 No Data 1,900 9,600 19,000 No Data

Swine

- Direct Applied 0.049 0.0085 0.0017 0.00085 No Data 1,000 5,100 10,000 No Data Lactating Dairy Cattle

- Direct Applied 0.0049 0.00085 0.00017 0.000085 No Data 10,000 51,000 100,000 No Data

0.0013 0.00023 0.00045 0.000023 No Data 38,000 190,000 380,000 No Data
Poultry Buildings (Walls, Ceilings, Floors, Larvicide)

- 0.00077 lb ai/ sq ft 20,000

sq ft 0.0067 0.0013 0.00067 No Data 1,300 6,500 13,000 No Data

Poultry Buildings (Floor Management, Fowl Tick, Larvicide) 0.00064 0.0056 0.0011 0.00056 No Data 1,600 7,800 16,000 No Data

Poultry (Caged)

- Direct Applied 0.00031

lb ai/ bird 20,000

birds 0.0027 0.00054 0.00027 No Data 3,200 16,000 32,000 No Data

Poultry Buildings (Flies Residual)

- 0.00013 20,000 sq ft 0.0011 0.00023 0.00011 No Data 7,700 38,000 77,000 No Data
Poultry (Chicken on Litter)

- Direct Applied 0.000078

lb ai/ bird 20,000

birds 0.00068 0.00014 0.000068 No Data 13,000 64,000 130,000 No Data

Poultry Floor Management 0.000064

lb ai/ 20,000

sq ft 0.00056 0.00011 0.000056 No Data 16,000 78,000 160,000 No Data

## Page 88 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates

. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC
sq ft

(9c) Liquid: Mechanically

- Pressurized Handgun Beef Cattle

- Direct

Applied 0.039

(lb ai/ animal)

400

animals 0.018 0.0036 0.0018 No Data 490 2,400 4,900 No Data

0.032 0.015 0.0029 0.0015 No Data 590 3,000 5,900 No Data Woody Borders of Kennels, Yards, Campgrounds, Recreational Parks, Footpaths and Roadways 0.026

(lb ai/ animal) 0.012 0.0024 0.0012 No Data 730 3,600 7,300 No Data

Beef Cattle

- Direct Applied 0.049 0.023 0.0045 0.0023 No Data 380 1,900 3,800 No Data
Swine

- Direct Applied 0.0049 0.0023 0.00045 0.00023 No Data 3,800 19,000 38,000 No Data Lactating Dairy Cattle

- Direct Applied 0.0013 0.00060 0.00012 0.000060 No Data 15,000 73,000 150,000 No Data

Poultry Buildings (Walls, Ceilings, Floors, Larvicide)

- 0.00077 lb ai/ sq ft 20,000

sq ft 0.018 0.0035 0.0018 No Data 490 2,500 4,900 No Data

Poultry Buildings (Floor Management, Fowl Tick, Larvicide) 0.00064 0.015 0.0029 0.0015 No Data 590 3,000 5,900 No Data

Poultry (Caged)

- Direct Applied 0.00032

lb ai/ bird 20,000

birds 0.0073 0.0015 0.00073 No Data 1,200 5,900 12,000 No Data

Poultry Buildings (Flies Residual) 0.00013 20,000 sq ft 0.0030 0.00060 0.00023 No Data 2,900 15,000 29,000 No Data
Poultry (Chicken on Litter)

- Direct Applied 0.000078

lb ai/ bird 20,000

birds 0.0018 0.00036 0.00018 No Data 4,900 24,000 49,000 No Data

Poultry Floor Management 0.000064

lb ai/ sq ft 20,000

sq ft 0.0015 0.00029 0.00015 No Data 5,900 30,000 59,000 No Data

## Page 89 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates

. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC

(9d) Liquid: Backrubber or Facerubber Cattle

- Direct

Applied 0.077

(lb ai/ gallon) 50

(gallons/ day) 0.000012 0.0000025 0.0000012 No Data 410,000 2,000,000 4,100,000 No Data

0.064 0.000010 0.0000020 0.0000010 No Data 490,000 2,500,000 4,900,000 No Data

(10a) Wettable Powder: Backpack Sprayer Beef Cattle

- Direct

Spray 0.040 400 animals 0.0070 0.0014 0.00070 No Data 1,200 6,200 12,000 No Data

Swine

- Direct Spray 0.020 0.0035 0.00070 0.00035 No Data 2,500 12,000 25,000 No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft 0.0070 0.0014 0.00070 No Data 1,200 6,200 12,000 No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds 0.0035 0.00070 0.00035 No Data 2,500 12,000 25,000 No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032

20,000 sq ft 0.0028 0.00056 0.00028 No Data 3,100 16,000 31,000 No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00016 0.0014 0.00028 0.00014 No Data 6,200 31,000 62,000 No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.000080 0.00070 0.00014 0.000070 No Data 12,000 62,000 120,000 No Data

Kennels, Yards, Campgrounds, Picnic Areas, and Recreational Parks 0.000040 1,000 sq ft (spot) 0.000017 0.0000035 0.0000017 No Data 500,000 2,500,000 5,000,000 No Data

## Page 90 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates

. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC

(10b) Wettable Powder: Manually

Pressurized Handwand Beef Cattle

- Direct

Spray 0.040 400 animals 0.0067 0.0014 0.00070 No Data 1,200 6,200 12,000 No Data

Swine

- Direct Spray 0.020 0.0035 0.00070 0.00035 No Data 2,500 12,000 25,000 No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft 0.0070 0.0014 0.00070 No Data 1,200 6,200 12,000 No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds 0.0035 0.00070 0.00035 No Data 2,500 12,000 25,000 No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 20,000 sq ft 0.0028 0.00056 0.00028 No Data 3,100 16,000 31,000 No Data 0.00016 0.0014 0.00028 0.00014 No Data 6,200 31,000 62,000 No Data

0.000080 0.00070 0.00014 0.000070 No Data 12,000 62,000 120,000 No Data

Kennels, Yards, Campgrounds, Picnic Areas, and Recreational Parks 0.000040 1,000 sq ft (spot) 0.000017 0.0000035 0.0000017 No Data 500,000 2,500,000 5,000,000 No Data

(10d and 10e) Wettable Powder: Handheld Fogger and Stationary Fogger Poultry (Floor

Management) 0.0016

lb ai/ bird 20,000

birds

No exposure data available for these use patterns. 0.00078 lb ai/ sq ft 20,000

sq ft Poultry (Floor Management Litter) 0.00023
(10f) Wettable Powder: Rotary Duster (Dust

- Plunger Data as Surrogate) Poultry (Floor

Management Litter) 0.00023 lb ai/ sq ft 20,000

sq ft 0.11 0.023 0.011 No Data 44 220 440 No Data

## Page 91 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates

. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC

(10g) Wettable Powder: Plunger Duster (Dust Data as Surrogate) Poultry (Floor

Management) 0.0016

lb ai/ bird 1,000

birds 0.039 0.0078 0.0039 No Data 130 640 1,300 No Data

0.00078 lb ai/ sq ft 1,000

sq ft 0.019 0.0038 0.0019 No Data 260 1,300 2,600 No Data

Poultry (Floor Management Litter) 0.00023 0.0056 0.0011 0.00056 No Data 880 4,400 8,800 No Data

(11a) Dust: Self

- Treating Dust Bag Cattle 0.75 lb ai/ dust bag 10

dust bags 0.18 0.037 0.018 No Data 27 140 270 No Data

0.38 0.093 0.019 0.0093 No Data 54 270 540 No Data 0.13 0.032 0.0064 0.0032 No Data 160 780 1,600 No Data

(11b) Dust: Shaker Can Cattle, Swine

–

Direct Applied 0.0075

(lb ai /animal) 400

animals 0.76 0.15 0.076 No Data 6.6 33 66 No Data

0.0038 0.39 0.077 0.039 No Data 13 65 130 No Data Cattle

– Direct Applied 0.0013 0.13 0.026 0.013 No Data 38 190 380 No Data

Poultry (Dust Box)

– Direct Applied 0.00060

(lb ai/ bird) 1,000

birds 0.15 0.030 0.015 No Data 33 160 330 No Data

Poultry (Floor Management) 0.00030

(lb ai/ sq ft) 1,000

sq ft 0.076 0.015 0.0076 No Data 66 330 660 No Data

Swine

- Bedding 0.00020 0.051 0.010 0.0051 No Data 98 490 980 No Data Poultry (Wire Cage)

– Direct Applied 0.00010 1,000 birds 0.025 0.0051 0.0025 No Data 200 980 2,000 No Data

(11c) Dust: Rotary Duster (Plunger Data as Surrogate) Cattle, Swine

–

Direct Applied 0.0075

(lb ai /animal) 400

animals 0.074 0.015 0.0074 No Data 68 340 680 No Data

0.0038 0.037 0.0075 0.0037 No Data 130 670 1,300 No Data Cattle

– Direct Applied 0.0013 0.013 0.0026 0.0013 No Data 390 2,000 3,900 No Data

Poultry (Dust Box)

– Direct Applied 0.00060

lb ai/ bird 20,000

birds 0.29 0.060 0.029 No Data 17 85 170 No Data

## Page 92 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates

. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC Poultry (Floor Management) 0.00030 20,000 sq ft 0.15 0.029 0.015 No Data 34 170 340 No Data Poultry (Wire Cage)

– Direct Applied 0.00010 20,000 birds 0.049 0.0098 0.0049 No Data 100 510 1,000 No Data

(11d) Dust: Plunger Duster Poultry (Dust Box)

– Direct Applied 0.00060

lb ai/ bird 1,000

birds 0.015 0.0029 0.0015 No Data 340 1,700 3,400 No Data

Poultry (Floor Management) 0.00030 1,000 sq ft 0.0074 0.0015 0.00074 No Data 680 3,400 6,800 No Data Poultry (Wire Cage)

– Direct Applied 0.00010 1,000 birds 0.0025 0.00049 0.00025 No Data 2,000 10,000 20,000 No Data

(12a) Paint: Brush or Roller Poultry (Roost

Paint) 0.08

lb ai/ gallon 2 gallons 0.00065 0.00013 0.000065 No Data 13,000 67,000 130,000 No Data

0.077 0.00063 0.00013 0.000063 No Data 14,000 69,000 140,000 No Data 0.064 0.00052 0.00010 0.000052 No Data 17,000 83,000 170,000 No Data 0.03 0.00024 0.000049 0.000024 No Data 36,000 180,000 360,000 No Data

(12b) Paint: Airless Poultry (Roost

Paint) 0.08

lb ai/ gallon 2 gallons 0.0013 0.00026 0.00013 No Data 3,800 19,000 38,000 No Data

0.077 0.0013 0.00025 0.00013 No Data 4,000 20,000 40,000 No Data 0.064 0.0010 0.00021 0.00010 No Data 4,800 24,000 48,000 No Data 0.03 0.00049 0.000097 0.000049 No Data 10,000 51,000 100,000 No Data (13) Solid Feed Additive for Feed Through Applications via Cup (Granular Data as Surrogate) Horse Feed 0.0015 (lb ai/ animal) 500

horses 0.00014 0.000027 0.000014 No Data 37,000 180,000 370,000 No Data

0.00077 0.000070 0.000014 0.0000070 No Data 72,000 360,000 720,000 No Data

Cattle Feed 0.0022 1,000

cows 0.00040 0.000080 0.000040 No Data 13,000 63,000 130,000 No Data

0.0017 0.00031 0.000062 0.000031 No Data 16,000 81,000 160,000 No Data

1. Inhalation exposures for exposure scenario (6) RTU Pet Collar Applications are considered negligible; therefore, the risk estimates presented are dermal MOEs and not ARIs since the dermal exposures are not being combined. For risk management purposes, the currently labeled level of PPE and EC has been identified (bolded) for each individual expo sure scenario.

## Page 93 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC

Mixer/Loaders

(10c) Wettable Powder: Mechanically

- Pressurized Handgun

MRID 42622301 Beef Cattle

- Direct

Spray 0.040 400 animals 0.0070 No Data No Data No Data 1,200 No Data No Data No Data
Swine

- Direct Spray 0.020 0.0035 No Data No Data No Data 2,500 No Data No Data No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft 0.035 No Data No Data No Data 250 No Data No Data No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds 0.0035 No Data No Data No Data 2,500 No Data No Data No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 20,000 sq ft 0.014 No Data No Data No Data 620 No Data No Data No Data 0.00016 0.0070 No Data No Data No Data 1,200 No Data No Data No Data

0.000080 0.0035 No Data No Data No Data 2,500 No Data No Data No Data

Applicators

(10c) Wettable Powder: Mechanically

- Pressurized Handgun

MRID 42622301 Beef Cattle

- Direct

Spray 0.040 400 animals 0.0016 No Data No Data No Data 5,300 No Data No Data No Data
Swine

- Direct Spray 0.020 0.00081 No Data No Data No Data 11,000 No Data No Data No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft 0.0081 No Data No Data No Data 1,100 No Data No Data No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds 0.00081 No Data No Data No Data 11,000 No Data No Data No Data

Dairy Barns, Poultry Houses, Swine Barns, or 0.00032 20,000 sq ft 0.0033 No Data No Data No Data 2,700 No Data No Data No Data 0.00016 0.0016 No Data No Data No Data 5,300 No Data No Data No Data 0.000080 0.000812 No Data No Data No Data 11,000 No Data No Data No Data

## Page 94 of 124 Table I.1. TCVP Occupational Handler Non

- Cancer Risk Estimates. Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Inhalation Dose (mg/kg/day) Inhalation MOEs (LOC is an MOE = 300 )

No R PF5 R PF10 R EC No R PF5 R PF10 R EC
other Animal Buildings Mixer/Loader/Applicators

(10c) Wettable Powder: Mechanically

- Pressurized Handgun

PHED Beef Cattle

- Direct

Spray 0.040 400 animals 0.018 0.0037 0.0018 No Data 470 2,400 4,700 No Data
Swine

- Direct Spray 0.020 0.0092 0.0018 0.00092 No Data 950 4,700 9,500 No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft 0.092 0.018 0.0092 No Data 95 470 950 No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds 0.0092 0.0018 0.00092 No Data 950 4,700 9,500 No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 20,000 sq ft 0.037 0.0073 0.0037 No Data 240 1,200 2,400 No Data 0.00016 0.018 0.0037 0.0018 No Data 470 2,400 4,700 No Data

0.000080 0.0092 0.0018 0.00092 No Data 950 4,700 9,500 No Data

For risk management purposes, the currently labeled level of PPE and EC has been identified (bolded) for each individual exposure scenario.

## Page 95 of 124

Appendix J

– Summary of Occupational Handler Cancer Risk Estimates

Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Mixer/Loaders

(1a) Mixing/ Loading Liquids for Groundboom Applications Poultry Buildings

(Including: Ceilings, Floors, Larvicide, Walls) 0.00077

(lb ai/ sq ft)

100,000

(sq ft/day) 5E

- 07 9E

- 08 7E

- 08 5E

- 07 9E

- 08 7E

- 08 5E

- 07 9E

- 08 7E

- 08 2E

- 08

Poultry Buildings (Including: Floor Management, Fowl Tick, Larvicide) 0.00064 4E

- 07 8E

- 08 6E

- 08 4E

- 07 8E

- 08 6E

- 08 4E

- 07 7E

- 08 6E

- 08 2E

- 08

Poultry Buildings (Flies Residual) 0.00013 9E

- 08 2E

- 08 1E

- 08 9E

- 08 2E

- 08 1E

- 08 9E

- 08 2E

- 08 1E

- 08 4E

- 09 Poultry Floor Management 0.000064 4E

- 08 8E

- 09 6E

- 09 4E

- 08 8E

- 09 6E

- 09 4E

- 08 7E

- 09 6E

- 09 2E

- 09
(1b) Mixing/ Loading Liquids for Paint Applications Poultry Buildings

(Roost) 0.077
2 gallons 1E

- 09 2E

- 10 1E

- 10 1E

- 09 2E

- 10 1E

- 10 1E

- 09 2E

- 10 1E

- 10 5E

- 11

0.064 (lb ai/ gallon) 9E

- 10 2E

- 10 1E

- 10 9E

- 10 2E

- 10 1E

- 10 9E

- 10 1E

- 10 1E

- 10 4E

- 11

(2a) Mixing/ Loading Wettable Powders for Groundboom Applications Poultry Buildings

(Including: Droppings, Floor Management Litter, Fowl Tick, Garbage Piles, Manure Piles, Under Feed Troughs) 0.00080

(lb ai/ sq ft) 100,000

sq ft 1E

- 05 2E

- 06 1E

- 06 9E

- 06 6E

- 07 5E

- 07 9E

- 06 5E

- 07 4E

- 07 3E

- 08

Dairy Barns, Poultry Houses, Swine Barns, or Other Animal Buildings 0.00032 4E

- 06 6E

- 07 6E

- 07 4E

- 06 3E

- 07 2E

- 07 4E

- 06 2E

- 07 2E

- 07 1E

- 08

## Page 96 of 124 Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

(2b, 2c) Mixing/ Loading Wettable Powders for Handheld Fogger, and Stationary Fogger Applications Poultry (Floor

Management

- Litter) 0.0016

(lb ai/ bird) 20,000

birds 4E

- 06 6E

- 07 6E

- 07 4E

- 06 3E

- 07 2E

- 07 4E

- 06 2E

- 07 2E

- 07 1E

- 08

0.00078 (lb ai/ sq ft) 100,000

sq ft 1E

- 05 1E

- 06 1E

- 06 9E

- 06 6E

- 07 5E

- 07 9E

- 06 5E

- 07 4E

- 07 3E

- 08

0.00023 3E

- 06 4E

- 07 4E

- 07 3E

- 06 2E

- 07 2E

- 07 3E

- 06 2E

- 07 1E

- 07 9E

- 09

(2d) Mixing/ Loading Wettable Powders for Paint Applications Poultry (Floor

Management

– Roost) 0.080

(lb ai/ gallon)

2 gallons 2E

- 08 3E

- 09 3E

- 09 2E

- 08 1E

- 09 1E

- 09 2E

- 08 1E

- 09 9E

- 10 6E

- 11

(3a) Mixing/ Loading Dusts for Paint Applications (WP Data as Surrogate) 0.030 (lb ai/ gallon) 8E

- 09 1E

- 09 1E

- 09 7E

- 09 5E

- 10 4E

- 10 7E

- 09 4E

- 10 3E

- 10 2E

- 11

Applicators

(4) Groundboom Applications Poultry Buildings

(Including: Droppings, Floor Management Litter, Fowl Tick, Garbage Piles, Manure Piles, Under Feed Troughs) 0.00080

(lb ai/ sq ft) 100,000

sq ft 2E

- 07 5E

- 08 4E

- 08 2E

- 07 4E

- 08 3E

- 08 2E

- 07 4E

- 08 3E

- 08 1E

- 08

Poultry Buildings (Including: Ceilings, Floors, Larvicide, Walls) 0.00077 2E

- 07 5E

- 08 4E

- 08 2E

- 07 4E

- 08 3E

- 08 2E

- 07 4E

- 08 3E

- 08 1E

- 08

## Page 97 of 124 Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Poultry Buildings (Including: Floor Management, Fowl Tick, Larvicide) 0.00064 2E

- 07 4E

- 08 3E

- 08 2E

- 07 3E

- 08 3E

- 08 2E

- 07 3E

- 08 3E

- 08 1E

- 08

Dairy Barns, Poultry Houses, Swine Barns, or Other Animal Buildings 0.00032 8E

- 08 2E

- 08 2E

- 08 8E

- 08 2E

- 08 1E

- 08 8E

- 08 2E

- 08 1E

- 08 5E

- 09

Poultry Buildings (Flies Residual) 0.00013 3E

- 08 8E

- 09 6E

- 09 3E

- 08 7E

- 09 5E

- 09 3E

- 08 7E

- 09 5E

- 09 2E

- 09 Poultry (Floor Management) 0.000064 2E

- 08 4E

- 09 3E

- 09 2E

- 08 3E

- 09 3E

- 09 2E

- 08 3E

- 09 3E

- 09 1E

- 09

(5) Open Pour Liquid Additive for Feed Through Applications Cattle Feed

(Concentrate) 0.0039

(lb ai/ animal) 1,000

cows 3E

- 08 5E

- 09 4E

- 09 3E

- 08 5E

- 09 4E

- 09 3E

- 08 5E

- 09 3E

- 09 No Data

Cattle Feed (Concentrate) 0.0022 2E

- 08 3E

- 09 2E

- 09 1E

- 08 3E

- 09 2E

- 09 1E

- 08 3E

- 09 2E

- 09 No Data

Horse Feed 0.0017 500 horses 6E

- 09 1E

- 09 8E

- 10 6E

- 09 1E

- 09 8E

- 10 6E

- 09 1E

- 09 8E

- 10 No Data

Swine Feed 0.00060 6,250 pigs 3E

- 08 5E

- 09 4E

- 09 3E

- 08 4E

- 09 3E

- 09 3E

- 08 4E

- 09 3E

- 09 No Data

(6 a ) RTU Pet Collar Applications

- Liquid Formulation Cat (2596

- 49) 0.0036

8 animals 1E

- 07 6E

- 08 4E

- 08 No Data No Data No Data No Data No Data No Data No Data Dog (2596

- 50,62)

- Small 0.0061 2E

- 07 1E

- 07 6E

- 08 No Data No Data No Data No Data No Data No Data No Data Dog (2596

- 50,62)

- Large 0.010 3E

- 07 2E

- 07 1E

- 07 No Data No Data No Data No Data No Data No Data No Data Cat (2596

- 63)

- Small 0.0048 1E

- 07 8E

- 08 5E

- 08 No Data No Data No Data No Data No Data No Data No Data
Cat (2596

- 63)

- Large 0.0055 2E

- 07 9E

- 08 6E

- 08 No Data No Data No Data No Data No Data No Data No Data Cat (2596

- 83)

- Small 0.0039 1E

- 07 7E

- 08 4E

- 08 No Data No Data No Data No Data No Data No Data No Data

Cat (2596

- 83)

- Large 0.0080 2E

- 07 1E

- 07 8E

- 08 No Data No Data No Data No Data No Data No Data No Data

Dog (2596

- 84)

– Small 0.0061 2E

- 07 1E

- 07 6E

- 08 No Data No Data No Data No Data No Data No Data No Data

## Page 98 of 124 Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Dog (2596

- 84)

– Large 0.010 3E

- 07 2E

- 07 1E

- 07 No Data No Data No Data No Data No Data No Data No Data Cat (2596

- 139)

- All 0.0032 9E

- 08 5E

- 08 3E

- 08 No Data No Data No Data No Data No Data No Data No Data Dog (2596

- 139)

- All 0.016 4E

- 07 3E

- 07 2E

- 07 No Data No Data No Data No Data No Data No Data No Data Dog (11556

- 164)

- All 0.0072 2E

- 07 1E

- 07 7E

- 08 No Data No Data No Data No Data No Data No Data No Data Cat (11556

- 165)

- All 0.0045 1E

- 07 8E

- 08 5E

- 08 No Data No Data No Data No Data No Data No Data No Data

(6 b ) RTU Pet Collar Applications

- Dust Formulation Cat (2596

- 49) 0.0036 4E

- 06 3E

- 07 2E

- 07 4E

- 06 1E

- 07 1E

- 07 4E

- 06 1E

- 07 8E

- 08 No Data

Dog (2596

- 50,62)

- Small 0.0061 6E

- 06 4E

- 07 4E

- 07 6E

- 06 2E

- 07 2E

- 07 6E

- 06 2E

- 07 1E

- 07 No Data

Dog (2596

- 50,62)

- Large 0.010 1E

- 05 7E

- 07 6E

- 07 1E

- 05 4E

- 07 3E

- 07 1E

- 05 3E

- 07 2E

- 07 No Data

Cat (2596

- 63)

- Small 0.0048 5E

- 06 3E

- 07 3E

- 07 5E

- 06 2E

- 07 1E

- 07 5E

- 06 2E

- 07 1E

- 07 No Data

Cat (2596

- 63)

- Large 0.0055 6E

- 06 4E

- 07 3E

- 07 6E

- 06 2E

- 07 1E

- 07 6E

- 06 2E

- 07 1E

- 07 No Data

Cat (2596

- 83)

- Small 0.0039 4E

- 06 3E

- 07 2E

- 07 4E

- 06 1E

- 07 1E

- 07 4E

- 06 1E

- 07 9E

- 08 No Data

Cat (2596

- 83)

- Large 0.0080 8E

- 06 6E

- 07 5E

- 07 8E

- 06 3E

- 07 2E

- 07 8E

- 06 3E

- 07 2E

- 07 No Data

Dog (2596

- 84)

– Small 0.0061 6E

- 06 4E

- 07 4E

- 07 6E

- 06 2E

- 07 2E

- 07 6E

- 06 2E

- 07 1E

- 07 No Data

Dog (2596

- 84)

– Large 0.010 1E

- 05 7E

- 07 6E

- 07 1E

- 05 4E

- 07 3E

- 07 1E

- 05 3E

- 07 2E

- 07 No Data

Cat (2596

- 139)

- All 0.0032 3E

- 06 2E

- 07 2E

- 07 3E

- 06 1E

- 07 9E

- 08 3E

- 06 1E

- 07 7E

- 08 No Data

Dog (2596

- 139)

- All 0.016 2E

- 05 1E

- 06 1E

- 06 2E

- 05 6E

- 07 4E

- 07 2E

- 05 5E

- 07 4E

- 07 No Data

Dog (11556

- 164)

- All 0.0072 8E

- 06 5E

- 07 5E

- 07 7E

- 06 3E

- 07 2E

- 07 7E

- 06 2E

- 07 2E

- 07 No Data

## Page 99 of 124 Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Cat (11556

- 165)

- All 0.0045 5E

- 06 3E

- 07 3E

- 07 5E

- 06 2E

- 07 1E

- 07 5E

- 06 1E

- 07 1E

- 07 No Data

(7) RTU Dust/Powder Applications Dog (47000

- 123)

-

Small 0.00037 4E

- 07 3E

- 08 2E

- 08 4E

- 07 1E

- 08 1E

- 08 4E

- 07 1E

- 08 8E

- 09 No Data Dog (47000

- 123)

- Medium 0.00094 1E

- 06 7E

- 08 6E

- 08 9E

- 07 3E

- 08 3E

- 08 9E

- 07 3E

- 08 2E

- 08 No Data Dog (47000

- 123)

- Large 0.0015 2E

- 06 1E

- 07 9E

- 08 2E

- 06 5E

- 08 4E

- 08 2E

- 06 5E

- 08 3E

- 08 No Data

Cat (47000

- 123)

- Small 0.000090 9E

- 08 6E

- 09 6E

- 09 9E

- 08 3E

- 09 2E

- 09 9E

- 08 3E

- 09 2E

- 09 No Data Cat (47000

- 123)

- Medium 0.00022 2E

- 07 2E

- 08 1E

- 08 2E

- 07 8E

- 09 6E

- 09 2E

- 07 7E

- 09 5E

- 09 No Data Cat (47000

- 123)

- Large 0.00034 4E

- 07 2E

- 08 2E

- 08 3E

- 07 1E

- 08 9E

- 09 3E

- 07 1E

- 08 8E

- 09 No Data Cat (2596

- 78)

- Small 0.00062 6E

- 07 4E

- 08 4E

- 08 6E

- 07 2E

- 08 2E

- 08 6E

- 07 2E

- 08 1E

- 08 No Data Cat (2596

- 78)

- Large 0.0010 1E

- 06 7E

- 08 6E

- 08 1E

- 06 4E

- 08 3E

- 08 1E

- 06 3E

- 08 2E

- 08 No Data Dog (2596

- 79)

- Small 0.0010 1E

- 06 7E

- 08 6E

- 08 1E

- 06 4E

- 08 3E

- 08 1E

- 06 3E

- 08 2E

- 08 No Data Dog (2596

- 79)

- Medium 0.0021 2E

- 06 2E

- 07 1E

- 07 2E

- 06 8E

- 08 6E

- 08 2E

- 06 7E

- 08 5E

- 08 No Data Dog (2596

- 79)

- Large 0.0026 3E

- 06 2E

- 07 2E

- 07 3E

- 06 9E

- 08 7E

- 08 3E

- 06 8E

- 08 6E

- 08 No Data Dog (67517

- 82)

- Small 0.0011 1E

- 06 8E

- 08 7E

- 08 1E

- 06 4E

- 08 3E

- 08 1E

- 06 3E

- 08 2E

- 08 No Data Dog (67517

- 82)

- Medium 0.0028 3E

- 06 2E

- 07 2E

- 07 3E

- 06 1E

- 07 8E

- 08 3E

- 06 9E

- 08 6E

- 08 No Data Dog (67517

- 82)

- Large 0.0045 5E

- 06 3E

- 07 3E

- 07 5E

- 06 2E

- 07 1E

- 07 5E

- 06 1E

- 07 1E

- 07 No Data Cat (67517

- 82)

- Small 0.00028 3E

- 07 2E

- 08 2E

- 08 3E

- 07 1E

- 08 8E

- 09 3E

- 07 9E

- 09 6E

- 09 No Data Cat (67517

- 82)

- Medium 0.00067 7E

- 07 5E

- 08 4E

- 08 7E

- 07 2E

- 08 2E

- 08 7E

- 07 2E

- 08 2E

- 08 No Data Cat (67517

- 82)

- Large 0.0010 1E

- 06 7E

- 08 6E

- 08 1E

- 06 4E

- 08 3E

- 08 1E

- 06 3E

- 08 2E

- 08 No Data

## Page 100 of 124 Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

(8) RTU Pump/Trigger Spray Applications Cat (2596

- 126,140)

- Trigger

- Small 0.00055 8E

- 08 7E

- 08 4E

- 08 7E

- 08 7E

- 08 4E

- 08 7E

- 08 7E

- 08 4E

- 08 No Data Cat (2596

- 126,140)

- Trigger

- Large 0.00077 1E

- 07 1E

- 07 6E

- 08 1E

- 07 1E

- 07 5E

- 08 1E

- 07 1E

- 07 5E

- 08 No Data Cat (2596

- 140)

- Pump

- Small 0.00011 2E

- 08 1E

- 08 8E

- 09 1E

- 08 1E

- 08 8E

- 09 1E

- 08 1E

- 08 7E

- 09 No Data Cat (2596

- 140)

- Pump

- Large 0.00016 2E

- 08 2E

- 08 1E

- 08 2E

- 08 2E

- 08 1E

- 08 2E

- 08 2E

- 08 1E

- 08 No Data

Dog (2596

- 125,

- 140)

- Small 0.00077 1E

- 07 1E

- 07 6E

- 08 1E

- 07 1E

- 07 5E

- 08 1E

- 07 1E

- 07 5E

- 08 No Data

Dog (2596

- 125,

- 140)

- Medium 0.00088 1E

- 07 1E

- 07 7E

- 08 1E

- 07 1E

- 07 6E

- 08 1E

- 07 1E

- 07 6E

- 08 No Data Dog (2596

- 125,

- 140)

- Large 0.0015 2E

- 07 2E

- 07 1E

- 07 2E

- 07 2E

- 07 1E

- 07 2E

- 07 2E

- 07 1E

- 07 No Data
Mixers/Loaders/Applicators

(9a) Liquid: Backpack Sprayer Beef Cattle

- Direct

Applied 0.039

(lb ai/ animal) 400

animals 4E

- 06 4E

- 06 2E

- 06 4E

- 06 4E

- 06 2E

- 06 4E

- 06 4E

- 06 2E

- 06 No Data

0.032 1E

- 06 1E

- 06 8E

- 07 1E

- 06 1E

- 06 7E

- 07 1E

- 06 1E

- 06 6E

- 07 No Data Woody Borders of Kennels, Yards, Campgrounds, Recreational Parks, Footpaths and Roadways 0.032

(lb ai/ sq ft) 1,000

sq ft (spot) 3E

- 06 3E

- 06 2E

- 06 3E

- 06 3E

- 06 2E

- 06 3E

- 06 2E

- 06 2E

- 06 No Data

Beef Cattle

- Direct Applied 0.026

(lb ai/ animal) 400

animals 9E

- 07 9E

- 07 6E

- 07 8E

- 07 8E

- 07 5E

- 07 8E

- 07 8E

- 07 5E

- 07 No Data

Swine

- Direct Applied 0.049 2E

- 06 2E

- 06 1E

- 06 2E

- 06 2E

- 06 1E

- 06 2E

- 06 2E

- 06 1E

- 06 No Data Lactating Dairy Cattle

- Direct Applied 0.0049 2E

- 07 2E

- 07 1E

- 07 2E

- 07 2E

- 07 1E

- 07 2E

- 07 2E

- 07 1E

- 07 No Data

0.0013 5E

- 08 5E

- 08 3E

- 08 4E

- 08 4E

- 08 3E

- 08 4E

- 08 4E

- 08 3E

- 08 No Data
Poultry Buildings (Walls, Ceilings, Floors, Larvicide) 0.00077 lb ai/ sq ft 20,000

sq ft 1E

- 06 1E

- 06 9E

- 07 1E

- 06 1E

- 06 8E

- 07 1E

- 06 1E

- 06 8E

- 07 No Data

## Page 101 of 124 Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Poultry Buildings (Floor Management, Fowl Tick, Larvicide) 0.00064 1E

- 06 1E

- 06 8E

- 07 1E

- 06 1E

- 06 7E

- 07 1E

- 06 1E

- 06 6E

- 07 No Data

Poultry (Caged)

- Direct Applied 0.00031

lb ai/ bird 20,000

birds 6E

- 07 6E

- 07 4E

- 07 5E

- 07 5E

- 07 3E

- 07 5E

- 07 5E

- 07 3E

- 07 No Data

Poultry Buildings (Flies Residual)

- 0.00013 20,000 sq ft 5E

- 07 5E

- 07 4E

- 07 5E

- 07 5E

- 07 3E

- 07 5E

- 07 5E

- 07 3E

- 07 No Data
Poultry (Chicken on Litter)

- Direct Applied 0.000078

lb ai/ bird 20,000

birds 2E

- 07 2E

- 07 2E

- 07 2E

- 07 2E

- 07 1E

- 07 2E

- 07 2E

- 07 1E

- 07 No Data

Poultry Floor Management 0.000064

lb ai/ sq ft 20,000

sq ft 1E

- 07 1E

- 07 9E

- 08 1E

- 07 1E

- 07 8E

- 08 1E

- 07 1E

- 07 8E

- 08 No Data

(9b) Liquid: Manually

Pressurized Handwand Beef Cattle

- Direct

Applied 0.039

(lb ai/ animal) 400

animals 5E

- 05 4E

- 07 3E

- 07 5E

- 05 2E

- 07 2E

- 07 5E

- 05 2E

- 07 2E

- 07 No Data

0.032 4E

- 05 3E

- 07 3E

- 07 4E

- 05 2E

- 07 2E

- 07 4E

- 05 2E

- 07 2E

- 07 No Data Woody Borders of Kennels, Yards, Campgrounds, Recreational Parks, Footpaths and Roadways 0.032

(lb ai/ sq ft) 1,000

sq ft (spot) 1E

- 04 7E

- 07 7E

- 07 1E

- 04 5E

- 07 4E

- 07 1E

- 04 5E

- 07 4E

- 07 No Data

Beef Cattle

- Direct Applied 0.026

(lb ai/ animal) 400

animals 3E

- 05 2E

- 07 2E

- 07 3E

- 05 2E

- 07 1E

- 07 3E

- 05 1E

- 07 1E

- 07 No Data

Swine

- Direct Applied 0.049 6E

- 05 4E

- 07 4E

- 07 6E

- 05 3E

- 07 3E

- 07 6E

- 05 3E

- 07 2E

- 07 No Data Lactating Dairy Cattle

- Direct Applied 0.0049 6E

- 06 4E

- 08 4E

- 08 6E

- 06 3E

- 08 3E

- 08 6E

- 06 3E

- 08 2E

- 08 No Data

0.0013 2E

- 06 1E

- 08 1E

- 08 2E

- 06 8E

- 09 7E

- 09 2E

- 06 7E

- 09 6E

- 09 No Data

## Page 102 of 124 Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Poultry Buildings (Walls, Ceilings, Floors, Larvicide)

- 0.00077 lb ai/ sq ft 20,000

sq ft 5E

- 05 4E

- 07 3E

- 07 5E

- 05 2E

- 07 2E

- 07 5E

- 05 2E

- 07 2E

- 07 No Data

Poultry Buildings (Floor Management, Fowl Tick, Larvicide) 0.00064 4E

- 05 3E

- 07 3E

- 07 4E

- 05 2E

- 07 2E

- 07 4E

- 05 2E

- 07 2E

- 07 No Data

Poultry (Caged)

- Direct Applied 0.00031

lb ai/ bird 20,000

birds 2E

- 05 1E

- 07 1E

- 07 2E

- 05 1E

- 07 8E

- 08 2E

- 05 9E

- 08 8E

- 08 No Data

Poultry Buildings (Flies Residual)

- 0.00013 20,000 sq ft 2E

- 05 1E

- 07 1E

- 07 2E

- 05 9E

- 08 8E

- 08 2E

- 05 9E

- 08 7E

- 08 No Data
Poultry (Chicken on Litter)

- Direct Applied 0.000078

lb ai/ bird 20,000

birds 8E

- 06 6E

- 08 5E

- 08 8E

- 06 4E

- 08 3E

- 08 8E

- 06 4E

- 08 3E

- 08 No Data

Poultry Floor Management 0.000064

lb ai/ sq ft 20,000

sq ft 5E

- 06 4E

- 08 3E

- 08 5E

- 06 2E

- 08 2E

- 08 5E

- 06 2E

- 08 2E

- 08 No Data

(9c) Liquid: Mechanically

- Pressurized Handgun Beef Cattle

- Direct

Applied 0.039

(lb ai/ animal)

400

animals 1E

- 06 7E

- 07 6E

- 07 9E

- 07 4E

- 07 3E

- 07 9E

- 07 3E

- 07 2E

- 07 No Data

0.032 1E

- 06 6E

- 07 5E

- 07 8E

- 07 3E

- 07 2E

- 07 7E

- 07 3E

- 07 2E

- 07 No Data Woody Borders of Kennels, Yards, Campgrounds, Recreational Parks, Footpaths and Roadways 0.026

(lb ai/ animal) 8E

- 07 5E

- 07 4E

- 07 6E

- 07 3E

- 07 2E

- 07 6E

- 07 2E

- 07 1E

- 07 No Data

Beef Cattle

- Direct Applied 0.049 2E

- 06 9E

- 07 7E

- 07 1E

- 06 5E

- 07 3E

- 07 1E

- 06 4E

- 07 3E

- 07 No Data
Swine

- Direct Applied 0.0049 2E

- 07 9E

- 08 7E

- 08 1E

- 07 5E

- 08 3E

- 08 1E

- 07 4E

- 08 3E

- 08 No Data Lactating Dairy Cattle

- Direct Applied 0.0013 4E

- 08 2E

- 08 2E

- 08 3E

- 08 1E

- 08 8E

- 09 3E

- 08 1E

- 08 7E

- 09 No Data

## Page 103 of 124 Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Poultry Buildings (Walls, Ceilings, Floors, Larvicide)

- 0.00077 lb ai/ sq ft 20,000

sq ft 1E

- 06 7E

- 07 6E

- 07 9E

- 07 4E

- 07 3E

- 07 9E

- 07 3E

- 07 2E

- 07 No Data

Poultry Buildings (Floor Management, Fowl Tick, Larvicide) 0.00064 1E

- 06 6E

- 07 5E

- 07 8E

- 07 3E

- 07 2E

- 07 7E

- 07 3E

- 07 2E

- 07 No Data

Poultry (Caged)

- Direct Applied 0.00031

lb ai/ bird 20,000

birds 5E

- 07 3E

- 07 2E

- 07 4E

- 07 2E

- 07 1E

- 07 4E

- 07 1E

- 07 9E

- 08 No Data

Poultry Buildings (Flies Residual) 0.00013 20,000 sq ft 5E

- 07 3E

- 07 2E

- 07 4E

- 07 1E

- 07 1E

- 07 3E

- 07 1E

- 07 8E

- 08 No Data
Poultry (Chicken on Litter)

- Direct Applied 0.000078

lb ai/ bird 20,000

birds 2E

- 07 1E

- 07 9E

- 08 2E

- 07 6E

- 08 4E

- 08 2E

- 07 6E

- 08 4E

- 08 No Data

Poultry Floor Management 0.000064

lb ai/ sq ft 20,000

sq ft 1E

- 07 7E

- 08 6E

- 08 9E

- 08 4E

- 08 3E

- 08 9E

- 08 3E

- 08 2E

- 08 No Data

(9d) Liquid: Backrubber or Facerubber Cattle

- Direct

Applied 0.077

(lb ai/ gallon) 50

(gallons/ day) 3E

- 08 5E

- 09 4E

- 09 3E

- 08 5E

- 09 3E

- 09 3E

- 08 5E

- 09 3E

- 09 No Data

0.064 2E

- 08 4E

- 09 3E

- 09 2E

- 08 4E

- 09 3E

- 09 2E

- 08 4E

- 09 3E

- 09 No Data

(10a) Wettable Powder: Backpack Sprayer Beef Cattle

- Direct

Spray 0.040 400 animals 1E

- 06 1E

- 06 9E

- 07 1E

- 06 1E

- 06 8E

- 07 1E

- 06 1E

- 06 8E

- 07 No Data

Swine

- Direct Spray 0.020 7E

- 07 7E

- 07 5E

- 07 6E

- 07 6E

- 07 4E

- 07 6E

- 07 6E

- 07 4E

- 07 No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft 1E

- 06 1E

- 06 9E

- 07 1E

- 06 1E

- 06 8E

- 07 1E

- 06 1E

- 06 8E

- 07 No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds 7E

- 07 7E

- 07 5E

- 07 6E

- 07 6E

- 07 4E

- 07 6E

- 07 6E

- 07 4E

- 07 No Data

## Page 104 of 124 Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032

20,000 sq ft 6E

- 07 6E

- 07 4E

- 07 5E

- 07 5E

- 07 3E

- 07 5E

- 07 5E

- 07 3E

- 07 No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00016 3E

- 07 3E

- 07 2E

- 07 3E

- 07 3E

- 07 2E

- 07 3E

- 07 2E

- 07 2E

- 07 No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.000080 1E

- 07 1E

- 07 9E

- 08 1E

- 07 1E

- 07 8E

- 08 1E

- 07 1E

- 07 8E

- 08 No Data

Kennels, Yards, Campgrounds, Picnic Areas, and Recreational Parks 0.000040 1,000 sq ft (spot) 3E

- 09 3E

- 09 2E

- 09 3E

- 09 3E

- 09 2E

- 09 3E

- 09 3E

- 09 2E

- 09 No Data

(10b) Wettable Powder: Manually

Pressurized Handwand Beef Cattle

- Direct

Spray 0.040 400 animals 5E

- 05 4E

- 07 3E

- 07 5E

- 05 2E

- 07 2E

- 07 5E

- 05 2E

- 07 2E

- 07 No Data

Swine

- Direct Spray 0.020 2E

- 05 2E

- 07 2E

- 07 2E

- 05 1E

- 07 1E

- 07 2E

- 05 1E

- 07 1E

- 07 No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft 5E

- 05 4E

- 07 3E

- 07 5E

- 05 2E

- 07 2E

- 07 5E

- 05 2E

- 07 2E

- 07 No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds 2E

- 05 2E

- 07 2E

- 07 2E

- 05 1E

- 07 1E

- 07 2E

- 05 1E

- 07 1E

- 07 No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 20,000 sq ft 2E

- 05 1E

- 07 1E

- 07 2E

- 05 1E

- 07 8E

- 08 2E

- 05 9E

- 08 8E

- 08 No Data 0.00016 1E

- 05 7E

- 08 7E

- 08 1E

- 05 5E

- 08 4E

- 08 1E

- 05 5E

- 08 4E

- 08 No Data

0.000080 5E

- 06 4E

- 08 3E

- 08 5E

- 06 2E

- 08 2E

- 08 5E

- 06 2E

- 08 2E

- 08 No Data

## Page 105 of 124 Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Kennels, Yards, Campgrounds, Picnic Areas, and Recreational Parks 0.000040 1,000 sq ft (spot) 1E

- 07 9E

- 10 8E

- 10 1E

- 07 6E

- 10 5E

- 10 1E

- 07 6E

- 10 5E

- 10 No Data

(10d and 10e) Wettable Powder: Handheld Fogger and Stationary Fogger Poultry (Floor

Management) 0.0016

lb ai/ bird 20,000

birds

No exposure data available for these use patterns. 0.00078 lb ai/ sq ft 20,000

sq ft Poultry (Floor Management Litter) 0.00023
(10f) Wettable Powder: Rotary Duster (Dust

- Plunger Data as Surrogate) Poultry (Floor

Management Litter) 0.00023 lb ai/ sq ft 20,000

sq ft 6E

- 04 9E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 No Data

(10g) Wettable Powder: Plunger Duster (Dust Data as Surrogate) Poultry (Floor

Management) 0.0016

lb ai/ bird 1,000

birds 9E

- 06 2E

- 06 2E

- 06 8E

- 06 1E

- 06 1E

- 06 8E

- 06 1E

- 06 1E

- 06 No Data

0.00078 lb ai/ sq ft 1,000

sq ft 4E

- 06 1E

- 06 9E

- 07 4E

- 06 7E

- 07 6E

- 07 4E

- 06 6E

- 07 5E

- 07 No Data

Poultry (Floor Management Litter) 0.00023 1E

- 06 3E

- 07 3E

- 07 1E

- 06 2E

- 07 2E

- 07 1E

- 06 2E

- 07 2E

- 07 No Data

(11a) Dust: Self

- Treating Dust Bag Cattle 0.75 lb ai/ dust bag 10

dust bags 4E

- 05 1E

- 05 9E

- 06 4E

- 05 7E

- 06 6E

- 06 4E

- 05 6E

- 06 5E

- 06 No Data

0.38 2E

- 05 5E

- 06 4E

- 06 2E

- 05 3E

- 06 3E

- 06 2E

- 05 3E

- 06 3E

- 06 No Data 0.13 7E

- 06 2E

- 06 2E

- 06 7E

- 06 1E

- 06 1E

- 06 7E

- 06 1E

- 06 9E

- 07 No Data

(11b) Dust: Shaker Can Cattle, Swine

–

Direct Applied 0.0075

(lb ai /animal) 400

animals 4E

- 04 3E

- 05 2E

- 05 4E

- 04 1E

- 05 1E

- 05 4E

- 04 1E

- 05 8E

- 06 No Data

0.0038 2E

- 04 1E

- 05 1E

- 05 2E

- 04 7E

- 06 5E

- 06 2E

- 04 6E

- 06 4E

- 06 No Data

## Page 106 of 124 Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Cattle

– Direct Applied 0.0013 7E

- 05 5E

- 06 4E

- 06 7E

- 05 2E

- 06 2E

- 06 6E

- 05 2E

- 06 1E

- 06 No Data

Poultry (Dust Box)

– Direct Applied 0.00060

(lb ai/ bird) 1,000

birds 8E

- 05 5E

- 06 5E

- 06 8E

- 05 3E

- 06 2E

- 06 8E

- 05 2E

- 06 2E

- 06 No Data

Poultry (Floor Management) 0.00030

(lb ai/ sq ft) 1,000

sq ft 4E

- 05 3E

- 06 2E

- 06 4E

- 05 1E

- 06 1E

- 06 4E

- 05 1E

- 06 8E

- 07 No Data

Swine

- Bedding 0.00020 3E

- 05 2E

- 06 2E

- 06 3E

- 05 9E

- 07 7E

- 07 3E

- 05 8E

- 07 6E

- 07 No Data Poultry (Wire Cage)

– Direct Applied 0.00010 1,000 birds 1E

- 05 9E

- 07 8E

- 07 1E

- 05 5E

- 07 3E

- 07 1E

- 05 4E

- 07 3E

- 07 No Data

(11c) Dust: Rotary Duster (Plunger Data as Surrogate) Cattle, Swine

–

Direct Applied 0.0075

(lb ai /animal) 400

animals 6E

- 04 9E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 No Data

0.0038 6E

- 04 9E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 No Data Cattle

– Direct Applied 0.0013 6E

- 04 9E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 No Data

Poultry (Dust Box)

– Direct Applied 0.00060

lb ai/ bird 20,000

birds 6E

- 04 9E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 No Data

Poultry (Floor Management) 0.00030 20,000 sq ft 6E

- 04 9E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 No Data Poultry (Wire Cage)

– Direct Applied 0.00010 20,000 birds 6E

- 04 9E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 No Data

(11d) Dust: Plunger Duster Poultry (Dust Box)

– Direct Applied 0.00060

lb ai/ bird 1,000

birds 6E

- 04 9E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 6E

- 04 8E

- 05 7E

- 05 No Data

Poultry (Floor Management) 0.00030 1,000 sq ft 1E

- 05 2E

- 06 1E

- 06 1E

- 05 2E

- 06 1E

- 06 1E

- 05 2E

- 06 1E

- 06 No Data Poultry (Wire Cage)

– Direct Applied 0.00010 1,000 birds 3E

- 04 4E

- 05 4E

- 05 3E

- 04 4E

- 05 3E

- 05 3E

- 04 4E

- 05 3E

- 05 No Data

(12a) Paint: Brush or Roller Poultry (Roost

Paint) 0.08

lb ai/ gallon 2 gallons 9E

- 07 1E

- 07 1E

- 07 9E

- 07 1E

- 07 1E

- 07 9E

- 07 1E

- 07 1E

- 07 No Data

0.077 9E

- 07 1E

- 07 1E

- 07 9E

- 07 1E

- 07 1E

- 07 9E

- 07 1E

- 07 1E

- 07 No Data

## Page 107 of 124 Table J.1. TCVP Occupational Handler Cancer Risk Estimates

– Private/ Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

0.064 7E

- 08 1E

- 08 1E

- 08 7E

- 08 1E

- 08 9E

- 09 7E

- 08 1E

- 08 9E

- 09 No Data 0.03 3E

- 07 5E

- 08 5E

- 08 3E

- 07 5E

- 08 4E

- 08 3E

- 07 4E

- 08 4E

- 08 No Data

(12b) Paint: Airless Poultry (Roost

Paint) 0.08

lb ai/ gallon 2 gallons 2E

- 07 9E

- 08 8E

- 08 2E

- 07 6E

- 08 6E

- 08 2E

- 07 6E

- 08 6E

- 08 No Data

0.077 2E

- 07 8E

- 08 8E

- 08 2E

- 07 6E

- 08 6E

- 08 2E

- 07 6E

- 08 5E

- 08 No Data 0.064 2E

- 08 7E

- 09 6E

- 09 2E

- 08 5E

- 09 5E

- 09 2E

- 08 5E

- 09 4E

- 09 No Data 0.03 9E

- 08 3E

- 08 3E

- 08 8E

- 08 2E

- 08 2E

- 08 8E

- 08 2E

- 08 2E

- 08 No Data (13) Solid Feed Additive for Feed Through Applications via Cup (Granular Data as Surrogate) Horse Feed 0.0015 (lb ai/ animal) 500

horses 1E

- 09 7E

- 10 7E

- 10 6E

- 10 2E

- 10 2E

- 10 6E

- 10 1E

- 10 1E

- 10 No Data

0.00077 6E

- 10 3E

- 10 3E

- 10 3E

- 10 9E

- 11 9E

- 11 3E

- 10 6E

- 11 6E

- 11 No Data

Cattle Feed 0.0022 1,000

cows 2E

- 08 1E

- 08 1E

- 08 9E

- 09 3E

- 09 3E

- 09 8E

- 09 2E

- 09 2E

- 09 No Data

0.0017 1E

- 08 7E

- 09 7E

- 09 7E

- 09 2E

- 09 2E

- 09 7E

- 09 1E

- 09 1E

- 09 No Data

1. Inhalation exposures for exposure scenario (6) RTU Pet Collar Applications are considered negligible; therefore, the cancer risk estimates presented are from dermal exposures only. For risk management purposes, the currently labeled level of PPE and EC has been identified (bolded) for each individual exposure scenario.

## Page 108 of 124 Table J.2. TCVP Occupational Handler Cancer Risk Estimates for Exposure Scenario 10c with Use of Chemical

- Specific Data and PHED

– Private/Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Mixer/Loaders

(10c) Wettable Powder: Mechanically

- Pressurized Handgun

MRID 42622301 Beef Cattle

- Direct

Spray 0.040 400 animals No Data 3E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data
Swine

- Direct Spray 0.020 No Data 2E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft No Data 2E

- 06 No Data No Data No Data No Data No Data No Data No Data No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds No Data 2E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 20,000 sq ft No Data 7E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data 0.00016 No Data 3E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data

0.000080 No Data 2E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data

Applicators

(10c) Wettable Powder: Mechanically

- Pressurized Handgun

MRID 42622301 Beef Cattle

- Direct

Spray 0.040 400 animals No Data 5E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data
Swine

- Direct Spray 0.020 No Data 2E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft No Data 2E

- 06 No Data No Data No Data No Data No Data No Data No Data No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds No Data 2E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data

Dairy Barns, Poultry Houses, Swine Barns, or 0.00032 20,000 sq ft No Data 1E

- 06 No Data No Data No Data No Data No Data No Data No Data No Data 0.00016 No Data 5E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data 0.000080 No Data 2E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data

## Page 109 of 124 Table J.2. TCVP Occupational Handler Cancer Risk Estimates for Exposure Scenario 10c with Use of Chemical

- Specific Data and PHED

– Private/Farmer Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Private/Farmer

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

other Animal Buildings Mixer/Loader/Applicators

(10c) Wettable Powder: Mechanically

- Pressurized Handgun

PHED Beef Cattle

- Direct

Spray 0.040 400 animals 1E

- 06 7E

- 07 6E

- 07 1E

- 06 4E

- 07 3E

- 07 9E

- 07 4E

- 07 2E

- 07 No Data
Swine

- Direct Spray 0.020 6E

- 07 4E

- 07 3E

- 07 5E

- 07 2E

- 07 1E

- 07 5E

- 07 2E

- 07 1E

- 07 No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft 6E

- 06 4E

- 06 3E

- 06 5E

- 06 2E

- 06 1E

- 06 5E

- 06 2E

- 06 1E

- 06 No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds 6E

- 07 4E

- 07 3E

- 07 5E

- 07 2E

- 07 1E

- 07 5E

- 07 2E

- 07 1E

- 07 No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 20,000 sq ft 3E

- 06 1E

- 06 1E

- 06 2E

- 06 8E

- 07 5E

- 07 2E

- 06 7E

- 07 4E

- 07 No Data 0.00016 1E

- 06 7E

- 07 6E

- 07 1E

- 06 4E

- 07 3E

- 07 9E

- 07 4E

- 07 2E

- 07 No Data

0.000080 6E

- 07 4E

- 07 3E

- 07 5E

- 07 2E

- 07 1E

- 07 5E

- 07 2E

- 07 1E

- 07 No Data

For risk management purposes, the currently labeled level of PPE and EC has been identified (bolded) for each individual expo sure scenario.

## Page 110 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Mixer/Loaders

(1a) Mixing/ Loading Liquids for Groundboom Applications Poultry Buildings

(Including: Ceilings, Floors, Larvicide, Walls) 0.00077

(lb ai/ sq ft)

100,000

(sq ft/day) 2E

- 06 3E

- 07 2E

- 07 2E

- 06 3E

- 07 2E

- 07 2E

- 06 3E

- 07 2E

- 07 7E

- 08

Poultry Buildings (Including: Floor Management, Fowl Tick, Larvicide) 0.00064 1E

- 06 2E

- 07 2E

- 07 1E

- 06 2E

- 07 2E

- 07 1E

- 06 2E

- 07 2E

- 07 6E

- 08

Poultry Buildings (Flies Residual) 0.00013 3E

- 07 5E

- 08 4E

- 08 3E

- 07 5E

- 08 4E

- 08 3E

- 07 5E

- 08 4E

- 08 1E

- 08 Poultry Floor Management 0.000064 1E

- 07 2E

- 08 2E

- 08 1E

- 07 2E

- 08 2E

- 08 1E

- 07 2E

- 08 2E

- 08 6E

- 09
(1b) Mixing/ Loading Liquids for Paint Applications Poultry Buildings

(Roost) 0.077
2 gallons 3E

- 09 6E

- 10 4E

- 10 3E

- 09 5E

- 10 4E

- 10 3E

- 09 5E

- 10 4E

- 10 1E

- 10

0.064 (lb ai/ gallon) 3E

- 09 5E

- 10 4E

- 10 3E

- 09 5E

- 10 3E

- 10 3E

- 09 4E

- 10 3E

- 10 1E

- 10

(2a) Mixing/ Loading Wettable Powders for Groundboom Applications Poultry Buildings

(Including: Droppings, Floor Management Litter, Fowl Tick, Garbage Piles, Manure Piles, Under Feed Troughs) 0.00080

(lb ai/ sq ft) 100,000

sq ft 3E

- 05 5E

- 06 4E

- 06 3E

- 05 2E

- 06 2E

- 06 3E

- 05 2E

- 06 1E

- 06 9E

- 08

Dairy Barns, Poultry Houses, Swine Barns, or Other Animal Buildings 0.00032 1E

- 05 2E

- 06 2E

- 06 1E

- 05 8E

- 07 7E

- 07 1E

- 05 6E

- 07 5E

- 07 4E

- 08

(2b, 2c) Mixing/ Loading Wettable Powders for Handheld Poultry (Floor

Management

- Litter) 0.0016

(lb ai/ bird) 20,000

birds 1E

- 05 2E

- 06 2E

- 06 1E

- 05 8E

- 07 7E

- 07 1E

- 05 6E

- 07 5E

- 07 4E

- 08

0.00078 (lb ai/ sq ft) 100,000

sq ft 3E

- 05 4E

- 06 4E

- 06 3E

- 05 2E

- 06 2E

- 06 3E

- 05 2E

- 06 1E

- 06 9E

- 08

## Page 111 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Fogger, and Stationary Fogger Applications 0.00023 9E

- 06 1E

- 06 1E

- 06 8E

- 06 6E

- 07 5E

- 07 8E

- 06 5E

- 07 4E

- 07 3E

- 08

(2d) Mixing/ Loading Wettable Powders for Paint Applications Poultry (Floor

Management

– Roost) 0.080

(lb ai/ gallon)

2 gallons 6E

- 08 9E

- 09 9E

- 09 6E

- 08 4E

- 09 3E

- 09 6E

- 08 3E

- 09 3E

- 09 2E

- 10

(3a) Mixing/ Loading Dusts for Paint Applications (WP Data as Surrogate) 0.030 (lb ai/ gallon) 2E

- 08 3E

- 09 3E

- 09 2E

- 08 1E

- 09 1E

- 09 2E

- 08 1E

- 09 1E

- 09 7E

- 11

Applicators

(4) Groundboom Applications Poultry Buildings

(Including: Droppings, Floor Management Litter, Fowl Tick, Garbage Piles, Manure Piles, Under Feed Troughs) 0.00080

(lb ai/ sq ft)

100,000

sq ft 6E

- 07 1E

- 07 1E

- 07 6E

- 07 1E

- 07 1E

- 07 6E

- 07 1E

- 07 1E

- 07 4E

- 08

Poultry Buildings (Including: Ceilings, Floors, Larvicide, Walls) 0.00077 6E

- 07 1E

- 07 1E

- 07 6E

- 07 1E

- 07 9E

- 08 6E

- 07 1E

- 07 9E

- 08 4E

- 08

Poultry Buildings (Including: Floor Management, Fowl Tick, Larvicide) 0.00064 5E

- 07 1E

- 07 1E

- 07 5E

- 07 1E

- 07 8E

- 08 5E

- 07 1E

- 07 8E

- 08 3E

- 08

Dairy Barns, Poultry Houses, 0.00032 2E

- 07 6E

- 08 5E

- 08 2E

- 07 5E

- 08 4E

- 08 2E

- 07 5E

- 08 4E

- 08 2E

- 08

## Page 112 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Swine Barns, or Other Animal Buildings Poultry Buildings (Flies Residual) 0.00013 1E

- 07 2E

- 08 2E

- 08 9E

- 08 2E

- 08 2E

- 08 9E

- 08 2E

- 08 2E

- 08 7E

- 09 Poultry (Floor Management) 0.000064 5E

- 08 1E

- 08 1E

- 08 5E

- 08 1E

- 08 8E

- 09 5E

- 08 1E

- 08 8E

- 09 3E

- 09

(5) Open Pour Liquid Additive for Feed Through Applications Cattle Feed

(Concentrate) 0.0039

(lb ai/ animal) 1,000

cows 8E

- 08 1E

- 08 1E

- 08 8E

- 08 1E

- 08 1E

- 08 8E

- 08 1E

- 08 1E

- 08 No Data

Cattle Feed (Concentrate) 0.0022 5E

- 08 8E

- 09 6E

- 09 4E

- 08 8E

- 09 6E

- 09 4E

- 08 8E

- 09 6E

- 09 No Data

Horse Feed 0.0017 500 horses 2E

- 08 3E

- 09 2E

- 09 2E

- 08 3E

- 09 2E

- 09 2E

- 08 3E

- 09 2E

- 09 No Data

Swine Feed 0.00060 6,250 pigs 8E

- 08 1E

- 08 1E

- 08 8E

- 08 1E

- 08 1E

- 08 8E

- 08 1E

- 08 1E

- 08 No Data

(6 a ) RTU Pet Collar Applications 1 Liquid Formulation Cat (2596

- 49) 0.0036

8 animals 3E

- 07 2E

- 07 1E

- 07 No Data No Data No Data No Data No Data No Data No Data Dog (2596

- 50,62)

- Small 0.0061 5E

- 07 3E

- 07 2E

- 07 No Data No Data No Data No Data No Data No Data No Data Dog (2596

- 50,62)

- Large 0.010 8E

- 07 5E

- 07 3E

- 07 No Data No Data No Data No Data No Data No Data No Data
Cat (2596

- 63)

- Small 0.0048 4E

- 07 2E

- 07 1E

- 07 No Data No Data No Data No Data No Data No Data No Data Cat (2596

- 63)

- Large 0.0055 5E

- 07 3E

- 07 2E

- 07 No Data No Data No Data No Data No Data No Data No Data Cat (2596

- 83)

- Small 0.0039 3E

- 07 2E

- 07 1E

- 07 No Data No Data No Data No Data No Data No Data No Data

Cat (2596

- 83)

- Large 0.0080 7E

- 07 4E

- 07 2E

- 07 No Data No Data No Data No Data No Data No Data No Data

Dog (2596

- 84)

– Small 0.0061 5E

- 07 3E

- 07 2E

- 07 No Data No Data No Data No Data No Data No Data No Data

Dog (2596

- 84)

– Large 0.010 8E

- 07 5E

- 07 3E

- 07 No Data No Data No Data No Data No Data No Data No Data Cat (2596

- 139)

- All 0.0032 3E

- 07 2E

- 07 1E

- 07 No Data No Data No Data No Data No Data No Data No Data Dog (2596

- 139)

- All 0.016 1E

- 06 8E

- 07 5E

- 07 No Data No Data No Data No Data No Data No Data No Data

## Page 113 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Dog (11556

- 164)

- All 0.0072 6E

- 07 4E

- 07 2E

- 07 No Data No Data No Data No Data No Data No Data No Data Cat (11556

- 165)

- All 0.0045 4E

- 07 2E

- 07 1E

- 07 No Data No Data No Data No Data No Data No Data No Data

(6 b ) RTU Pet Collar Applications

Dust Formulation Cat (2596

- 49) 0.0036 1E

- 05 8E

- 07 7E

- 07 1E

- 05 4E

- 07 3E

- 07 1E

- 05 3E

- 07 2E

- 07 No Data

Dog (2596

- 50,62)

- Small 0.0061 2E

- 05 1E

- 06 1E

- 06 2E

- 05 7E

- 07 5E

- 07 2E

- 05 6E

- 07 4E

- 07 No Data
Dog (2596

- 50,62)

- Large 0.010 3E

- 05 2E

- 06 2E

- 06 3E

- 05 1E

- 06 8E

- 07 3E

- 05 9E

- 07 7E

- 07 No Data
Cat (2596

- 63)

- Small 0.0048 2E

- 05 1E

- 06 9E

- 07 1E

- 05 5E

- 07 4E

- 07 1E

- 05 5E

- 07 3E

- 07 No Data
Cat (2596

- 63)

- Large 0.0055 2E

- 05 1E

- 06 1E

- 06 2E

- 05 6E

- 07 4E

- 07 2E

- 05 5E

- 07 4E

- 07 No Data
Cat (2596

- 83)

- Small 0.0039 1E

- 05 8E

- 07 7E

- 07 1E

- 05 4E

- 07 3E

- 07 1E

- 05 4E

- 07 3E

- 07 No Data
Cat (2596

- 83)

- Large 0.0080 3E

- 05 2E

- 06 2E

- 06 2E

- 05 9E

- 07 6E

- 07 2E

- 05 8E

- 07 5E

- 07 No Data
Dog (2596

- 84)

– Small 0.0061 2E

- 05 1E

- 06 1E

- 06 2E

- 05 7E

- 07 5E

- 07 2E

- 05 6E

- 07 4E

- 07 No Data
Dog (2596

- 84)

– Large 0.010 3E

- 05 2E

- 06 2E

- 06 3E

- 05 1E

- 06 8E

- 07 3E

- 05 9E

- 07 7E

- 07 No Data
Cat (2596

- 139)

- All 0.0032 1E

- 05 7E

- 07 6E

- 07 1E

- 05 3E

- 07 3E

- 07 1E

- 05 3E

- 07 2E

- 07 No Data
Dog (2596

- 139)

- All 0.016 5E

- 05 3E

- 06 3E

- 06 5E

- 05 2E

- 06 1E

- 06 5E

- 05 2E

- 06 1E

- 06 No Data
Dog (11556

- 164)

- All 0.0072 2E

- 05 2E

- 06 1E

- 06 2E

- 05 8E

- 07 6E

- 07 2E

- 05 7E

- 07 5E

- 07 No Data
Cat (11556

- 165)

- All 0.0045 1E

- 05 1E

- 06 9E

- 07 1E

- 05 5E

- 07 4E

- 07 1E

- 05 4E

- 07 3E

- 07 No Data

(7) RTU Dust/Powder Applications Dog (47000

- 123)

-

Small 0.00037 1E

- 06 8E

- 08 7E

- 08 1E

- 06 4E

- 08 3E

- 08 1E

- 06 4E

- 08 2E

- 08 No Data Dog (47000

- 123)

- Medium 0.00094 3E

- 06 2E

- 07 2E

- 07 3E

- 06 1E

- 07 8E

- 08 3E

- 06 9E

- 08 6E

- 08 No Data

## Page 114 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Dog (47000

- 123)

- Large 0.0015 5E

- 06 3E

- 07 3E

- 07 5E

- 06 2E

- 07 1E

- 07 5E

- 06 1E

- 07 1E

- 07 No Data Cat (47000

- 123)

- Small 0.000090 3E

- 07 2E

- 08 2E

- 08 3E

- 07 1E

- 08 7E

- 09 3E

- 07 9E

- 09 6E

- 09 No Data Cat (47000

- 123)

- Medium 0.00022 7E

- 07 5E

- 08 4E

- 08 7E

- 07 2E

- 08 2E

- 08 7E

- 07 2E

- 08 1E

- 08 No Data Cat (47000

- 123)

- Large 0.00034 1E

- 06 7E

- 08 6E

- 08 1E

- 06 4E

- 08 3E

- 08 1E

- 06 3E

- 08 2E

- 08 No Data Cat (2596

- 78)

- Small 0.00062 2E

- 06 1E

- 07 1E

- 07 2E

- 06 7E

- 08 5E

- 08 2E

- 06 6E

- 08 4E

- 08 No Data Cat (2596

- 78)

- Large 0.0010 3E

- 06 2E

- 07 2E

- 07 3E

- 06 1E

- 07 8E

- 08 3E

- 06 9E

- 08 7E

- 08 No Data Dog (2596

- 79)

- Small 0.0010 3E

- 06 2E

- 07 2E

- 07 3E

- 06 1E

- 07 8E

- 08 3E

- 06 9E

- 08 7E

- 08 No Data Dog (2596

- 79)

- Medium 0.0021 7E

- 06 5E

- 07 4E

- 07 6E

- 06 2E

- 07 2E

- 07 6E

- 06 2E

- 07 1E

- 07 No Data Dog (2596

- 79)

- Large 0.0026 8E

- 06 6E

- 07 5E

- 07 8E

- 06 3E

- 07 2E

- 07 8E

- 06 2E

- 07 2E

- 07 No Data Dog (67517

- 82)

- Small 0.0011 3E

- 06 2E

- 07 2E

- 07 3E

- 06 1E

- 07 9E

- 08 3E

- 06 1E

- 07 7E

- 08 No Data Dog (67517

- 82)

- Medium 0.0028 9E

- 06 6E

- 07 5E

- 07 8E

- 06 3E

- 07 2E

- 07 8E

- 06 3E

- 07 2E

- 07 No Data Dog (67517

- 82)

- Large 0.0045 1E

- 05 1E

- 06 9E

- 07 1E

- 05 5E

- 07 4E

- 07 1E

- 05 4E

- 07 3E

- 07 No Data Cat (67517

- 82)

- Small 0.00028 9E

- 07 6E

- 08 5E

- 08 8E

- 07 3E

- 08 2E

- 08 8E

- 07 3E

- 08 2E

- 08 No Data Cat (67517

- 82)

- Medium 0.00067 2E

- 06 1E

- 07 1E

- 07 2E

- 06 7E

- 08 5E

- 08 2E

- 06 6E

- 08 5E

- 08 No Data Cat (67517

- 82)

- Large 0.0010 3E

- 06 2E

- 07 2E

- 07 3E

- 06 1E

- 07 8E

- 08 3E

- 06 9E

- 08 7E

- 08 No Data

(8) RTU Pump/Trigger Spray Applications Cat (2596

- 126,140)

- Trigger

- Small 0.00055 2E

- 07 2E

- 07 1E

- 07 2E

- 07 2E

- 07 1E

- 07 2E

- 07 2E

- 07 1E

- 07 No Data Cat (2596

- 126,140)

- Trigger

- Large 0.00077 3E

- 07 3E

- 07 2E

- 07 3E

- 07 3E

- 07 2E

- 07 3E

- 07 3E

- 07 2E

- 07 No Data Cat (2596

- 140)

- Pump

- Small 0.00011 5E

- 08 4E

- 08 3E

- 08 4E

- 08 4E

- 08 2E

- 08 4E

- 08 4E

- 08 2E

- 08 No Data

## Page 115 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Cat (2596

- 140)

- Pump

- Large 0.00016 7E

- 08 6E

- 08 4E

- 08 7E

- 08 6E

- 08 3E

- 08 6E

- 08 6E

- 08 3E

- 08 No Data

Dog (2596

- 125,

- 140)

- Small 0.00077 3E

- 07 3E

- 07 2E

- 07 3E

- 07 3E

- 07 2E

- 07 3E

- 07 3E

- 07 2E

- 07 No Data

Dog (2596

- 125,

- 140)

- Medium 0.00088 4E

- 07 3E

- 07 2E

- 07 4E

- 07 3E

- 07 2E

- 07 4E

- 07 3E

- 07 2E

- 07 No Data Dog (2596

- 125,

- 140)

- Large 0.0015 6E

- 07 6E

- 07 3E

- 07 6E

- 07 6E

- 07 3E

- 07 6E

- 07 6E

- 07 3E

- 07 No Data
Mixers/Loaders/Applicators

(9a) Liquid: Backpack Sprayer Beef Cattle

- Direct

Applied 0.039

(lb ai/ animal) 400

animals 1E

- 05 1E

- 05 6E

- 06 1E

- 05 1E

- 05 6E

- 06 1E

- 05 1E

- 05 6E

- 06 No Data

0.032 3E

- 06 3E

- 06 2E

- 06 3E

- 06 3E

- 06 2E

- 06 3E

- 06 3E

- 06 2E

- 06 No Data Woody Borders of Kennels, Yards, Campgrounds, Recreational Parks, Footpaths and Roadways 0.032

(lb ai/ sq ft) 1,000

sq ft (spot) 8E

- 06 8E

- 06 6E

- 06 8E

- 06 8E

- 06 5E

- 06 8E

- 06 7E

- 06 5E

- 06 No Data

Beef Cattle

- Direct Applied 0.026

(lb ai/ animal) 400

animals 3E

- 06 3E

- 06 2E

- 06 2E

- 06 2E

- 06 2E

- 06 2E

- 06 2E

- 06 2E

- 06 No Data

Swine

- Direct Applied 0.049 5E

- 06 5E

- 06 3E

- 06 5E

- 06 5E

- 06 3E

- 06 5E

- 06 5E

- 06 3E

- 06 No Data Lactating Dairy Cattle

- Direct Applied 0.0049 5E

- 07 5E

- 07 3E

- 07 5E

- 07 5E

- 07 3E

- 07 5E

- 07 5E

- 07 3E

- 07 No Data

0.0013 1E

- 07 1E

- 07 9E

- 08 1E

- 07 1E

- 07 8E

- 08 1E

- 07 1E

- 07 8E

- 08 No Data
Poultry Buildings (Walls, Ceilings, Floors, Larvicide) 0.00077 lb ai/ sq ft 20,000

sq ft 4E

- 06 4E

- 06 3E

- 06 4E

- 06 4E

- 06 2E

- 06 4E

- 06 4E

- 06 2E

- 06 No Data

Poultry Buildings (Floor Management, Fowl Tick, Larvicide) 0.00064 3E

- 06 3E

- 06 2E

- 06 3E

- 06 3E

- 06 2E

- 06 3E

- 06 3E

- 06 2E

- 06 No Data

Poultry (Caged)

- Direct Applied 0.00031

lb ai/ 20,000

birds 2E

- 06 2E

- 06 1E

- 06 2E

- 06 2E

- 06 1E

- 06 2E

- 06 2E

- 06 1E

- 06 No Data

## Page 116 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

bird Poultry Buildings (Flies Residual)

- 0.00013 20,000 sq ft 2E

- 06 2E

- 06 1E

- 06 1E

- 06 1E

- 06 9E

- 07 1E

- 06 1E

- 06 9E

- 07 No Data
Poultry (Chicken on Litter)

- Direct Applied 0.000078

lb ai/ bird 20,000

birds 7E

- 07 7E

- 07 5E

- 07 6E

- 07 6E

- 07 4E

- 07 6E

- 07 6E

- 07 4E

- 07 No Data

Poultry Floor Management 0.000064

lb ai/ sq ft 20,000

sq ft 4E

- 07 4E

- 07 3E

- 07 4E

- 07 4E

- 07 2E

- 07 4E

- 07 4E

- 07 2E

- 07 No Data

(9b) Liquid: Manually

Pressurized Handwand Beef Cattle

- Direct

Applied 0.039

(lb ai/ animal) 400

animals 1E

- 04 1E

- 06 1E

- 06 1E

- 04 7E

- 07 6E

- 07 1E

- 04 7E

- 07 6E

- 07 No Data

0.032 1E

- 04 9E

- 07 8E

- 07 1E

- 04 6E

- 07 5E

- 07 1E

- 04 5E

- 07 5E

- 07 No Data Woody Borders of Kennels, Yards, Campgrounds, Recreational Parks, Footpaths and Roadways 0.032

(lb ai/ sq ft) 1,000

sq ft (spot) 3E

- 04 2E

- 06 2E

- 06 3E

- 04 1E

- 06 1E

- 06 3E

- 04 1E

- 06 1E

- 06 No Data

Beef Cattle

- Direct Applied 0.026

(lb ai/ animal) 400

animals 1E

- 04 7E

- 07 7E

- 07 1E

- 04 5E

- 07 4E

- 07 1E

- 04 4E

- 07 4E

- 07 No Data

Swine

- Direct Applied 0.049 2E

- 04 1E

- 06 1E

- 06 2E

- 04 9E

- 07 8E

- 07 2E

- 04 8E

- 07 7E

- 07 No Data Lactating Dairy Cattle

- Direct Applied 0.0049 2E

- 05 1E

- 07 1E

- 07 2E

- 05 9E

- 08 8E

- 08 2E

- 05 8E

- 08 7E

- 08 No Data

0.0013 5E

- 06 4E

- 08 3E

- 08 5E

- 06 2E

- 08 2E

- 08 5E

- 06 2E

- 08 2E

- 08 No Data
Poultry Buildings (Walls, Ceilings, Floors, Larvicide)

- 0.00077 lb ai/ sq ft 20,000

sq ft 1E

- 04 1E

- 06 1E

- 06 1E

- 04 7E

- 07 6E

- 07 1E

- 04 7E

- 07 6E

- 07 No Data

Poultry Buildings (Floor Management, Fowl Tick, Larvicide) 0.00064 1E

- 04 9E

- 07 8E

- 07 1E

- 04 6E

- 07 5E

- 07 1E

- 04 5E

- 07 5E

- 07 No Data

## Page 117 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Poultry (Caged)

- Direct Applied 0.00031

lb ai/ bird 20,000

birds 6E

- 05 4E

- 07 4E

- 07 6E

- 05 3E

- 07 3E

- 07 6E

- 05 3E

- 07 2E

- 07 No Data

Poultry Buildings (Flies Residual)

- 0.00013 20,000 sq ft 6E

- 05 4E

- 07 4E

- 07 6E

- 05 3E

- 07 2E

- 07 6E

- 05 3E

- 07 2E

- 07 No Data
Poultry (Chicken on Litter)

- Direct Applied 0.000078

lb ai/ bird 20,000

birds 2E

- 05 2E

- 07 2E

- 07 2E

- 05 1E

- 07 1E

- 07 2E

- 05 1E

- 07 9E

- 08 No Data

Poultry Floor Management 0.000064

lb ai/ sq ft 20,000

sq ft 1E

- 05 1E

- 07 1E

- 07 1E

- 05 7E

- 08 6E

- 08 1E

- 05 7E

- 08 6E

- 08 No Data

(9c) Liquid: Mechanically

- Pressurized Handgun Beef Cattle

- Direct

Applied 0.039

(lb ai/ animal)

400

animals 4E

- 06 2E

- 06 2E

- 06 3E

- 06 1E

- 06 8E

- 07 3E

- 06 1E

- 06 6E

- 07 No Data

0.032 3E

- 06 2E

- 06 1E

- 06 2E

- 06 9E

- 07 6E

- 07 2E

- 06 9E

- 07 5E

- 07 No Data Woody Borders of Kennels, Yards, Campgrounds, Recreational Parks, Footpaths and Roadways 0.026

(lb ai/ animal) 3E

- 06 1E

- 06 1E

- 06 2E

- 06 8E

- 07 5E

- 07 2E

- 06 7E

- 07 4E

- 07 No Data

Beef Cattle

- Direct Applied 0.049 5E

- 06 3E

- 06 2E

- 06 4E

- 06 1E

- 06 1E

- 06 3E

- 06 1E

- 06 8E

- 07 No Data
Swine

- Direct Applied 0.0049 5E

- 07 3E

- 07 2E

- 07 4E

- 07 1E

- 07 1E

- 07 3E

- 07 1E

- 07 8E

- 08 No Data Lactating Dairy Cattle

- Direct Applied 0.0013 1E

- 07 7E

- 08 6E

- 08 9E

- 08 4E

- 08 3E

- 08 9E

- 08 3E

- 08 2E

- 08 No Data

Poultry Buildings (Walls, Ceilings, Floors, Larvicide)

- 0.00077 lb ai/ sq ft 20,000

sq ft 4E

- 06 2E

- 06 2E

- 06 3E

- 06 1E

- 06 8E

- 07 3E

- 06 1E

- 06 6E

- 07 No Data

Poultry Buildings (Floor Management, Fowl Tick, Larvicide) 0.00064 3E

- 06 2E

- 06 1E

- 06 2E

- 06 9E

- 07 6E

- 07 2E

- 06 9E

- 07 5E

- 07 No Data

## Page 118 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Poultry (Caged)

- Direct Applied 0.00031

lb ai/ bird 20,000

birds 2E

- 06 9E

- 07 7E

- 07 1E

- 06 5E

- 07 3E

- 07 1E

- 06 4E

- 07 3E

- 07 No Data

Poultry Buildings (Flies Residual) 0.00013 20,000 sq ft 1E

- 06 8E

- 07 7E

- 07 1E

- 06 4E

- 07 3E

- 07 1E

- 06 4E

- 07 2E

- 07 No Data
Poultry (Chicken on Litter)

- Direct Applied 0.000078

lb ai/ bird 20,000

birds 6E

- 07 4E

- 07 3E

- 07 5E

- 07 2E

- 07 1E

- 07 5E

- 07 2E

- 07 1E

- 07 No Data

Poultry Floor Management 0.000064

lb ai/ sq ft 20,000

sq ft 4E

- 07 2E

- 07 2E

- 07 3E

- 07 1E

- 07 8E

- 08 3E

- 07 1E

- 07 6E

- 08 No Data

(9d) Liquid: Backrubber or Facerubber Cattle

- Direct

Applied 0.077

(lb ai/ gallon) 50

(gallons/ day) 8E

- 08 1E

- 08 1E

- 08 8E

- 08 1E

- 08 1E

- 08 8E

- 08 1E

- 08 1E

- 08 No Data

0.064 7E

- 08 1E

- 08 9E

- 09 7E

- 08 1E

- 08 9E

- 09 7E

- 08 1E

- 08 9E

- 09 No Data

(10a) Wettable Powder: Backpack Sprayer Beef Cattle

- Direct

Spray 0.040 400 animals 4E

- 06 4E

- 06 3E

- 06 4E

- 06 4E

- 06 2E

- 06 4E

- 06 4E

- 06 2E

- 06 No Data

Swine

- Direct Spray 0.020 2E

- 06 2E

- 06 1E

- 06 2E

- 06 2E

- 06 1E

- 06 2E

- 06 2E

- 06 1E

- 06 No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft 4E

- 06 4E

- 06 3E

- 06 4E

- 06 4E

- 06 2E

- 06 4E

- 06 4E

- 06 2E

- 06 No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds 2E

- 06 2E

- 06 1E

- 06 2E

- 06 2E

- 06 1E

- 06 2E

- 06 2E

- 06 1E

- 06 No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 20,000 sq ft 2E

- 06 2E

- 06 1E

- 06 2E

- 06 2E

- 06 1E

- 06 2E

- 06 2E

- 06 1E

- 06 No Data

Dairy Barns, Poultry Houses, Swine Barns, or 0.00016 8E

- 07 8E

- 07 6E

- 07 8E

- 07 8E

- 07 5E

- 07 8E

- 07 7E

- 07 5E

- 07 No Data

## Page 119 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

other Animal Buildings Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.000080 4E

- 07 4E

- 07 3E

- 07 4E

- 07 4E

- 07 2E

- 07 4E

- 07 4E

- 07 2E

- 07 No Data

Kennels, Yards, Campgrounds, Picnic Areas, and Recreational Parks 0.000040 1,000 sq ft (spot) 1E

- 08 1E

- 08 7E

- 09 9E

- 09 9E

- 09 6E

- 09 9E

- 09 9E

- 09 6E

- 09 No Data

(10b) Wettable Powder: Manually

Pressurized Handwand Beef Cattle

- Direct

Spray 0.040 400 animals 1E

- 04 1E

- 06 1E

- 06 1E

- 04 7E

- 07 6E

- 07 1E

- 04 7E

- 07 6E

- 07 No Data

Swine

- Direct Spray 0.020 7E

- 05 5E

- 07 5E

- 07 7E

- 05 4E

- 07 3E

- 07 7E

- 05 3E

- 07 3E

- 07 No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft 1E

- 04 1E

- 06 1E

- 06 1E

- 04 7E

- 07 6E

- 07 1E

- 04 7E

- 07 6E

- 07 No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds 7E

- 05 5E

- 07 5E

- 07 7E

- 05 4E

- 07 3E

- 07 7E

- 05 3E

- 07 3E

- 07 No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 20,000 sq ft 6E

- 05 4E

- 07 4E

- 07 6E

- 05 3E

- 07 3E

- 07 6E

- 05 3E

- 07 2E

- 07 No Data 0.00016 3E

- 05 2E

- 07 2E

- 07 3E

- 05 1E

- 07 1E

- 07 3E

- 05 1E

- 07 1E

- 07 No Data

0.000080 1E

- 05 1E

- 07 1E

- 07 1E

- 05 7E

- 08 6E

- 08 1E

- 05 7E

- 08 6E

- 08 No Data

Kennels, Yards, Campgrounds, Picnic Areas, and Recreational Parks 0.000040 1,000 sq ft (spot) 4E

- 07 3E

- 09 3E

- 09 4E

- 07 2E

- 09 2E

- 09 4E

- 07 2E

- 09 1E

- 09 No Data

(10d and 10e) Wettable Powder: Handheld Poultry (Floor

Management) 0.0016

lb ai/ bird 20,000

birds No exposure data available for these use patterns.

0.00078 20,000

## Page 120 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Fogger and Stationary Fogger lb ai/ sq ft sq ft

Poultry (Floor Management Litter) 0.00023
(10f) Wettable Powder: Rotary Duster (Dust

- Plunger Data as Surrogate) Poultry (Floor

Management Litter) 0.00023 lb ai/ sq ft 20,000

sq ft 2E

- 03 3E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 No Data

(10g) Wettable Powder: Plunger Duster (Dust Data as Surrogate) Poultry (Floor

Management) 0.0016

lb ai/ bird 1,000

birds 3E

- 05 6E

- 06 6E

- 06 3E

- 05 4E

- 06 4E

- 06 2E

- 05 4E

- 06 3E

- 06 No Data

0.00078 lb ai/ sq ft 1,000

sq ft 1E

- 05 3E

- 06 3E

- 06 1E

- 05 2E

- 06 2E

- 06 1E

- 05 2E

- 06 2E

- 06 No Data

Poultry (Floor Management Litter) 0.00023 4E

- 06 9E

- 07 8E

- 07 4E

- 06 6E

- 07 5E

- 07 4E

- 06 6E

- 07 5E

- 07 No Data

(11a) Dust: Self

- Treating Dust Bag Cattle 0.75 lb ai/ dust bag 10

dust bags 1E

- 04 3E

- 05 3E

- 05 1E

- 04 2E

- 05 2E

- 05 1E

- 04 2E

- 05 2E

- 05 No Data

0.38 6E

- 05 1E

- 05 1E

- 05 6E

- 05 1E

- 05 9E

- 06 6E

- 05 9E

- 06 8E

- 06 No Data

0.13 2E

- 05 5E

- 06 5E

- 06 2E

- 05 3E

- 06 3E

- 06 2E

- 05 3E

- 06 3E

- 06 No Data

(11b) Dust: Shaker Can (Plunger Data Surrogate) Cattle, Swine

–

Direct Applied 0.0075

(lb ai /animal) 400

animals 1E

- 03 8E

- 05 7E

- 05 1E

- 03 4E

- 05 3E

- 05 1E

- 03 4E

- 05 3E

- 05 No Data

0.0038 6E

- 04 4E

- 05 4E

- 05 6E

- 04 2E

- 05 2E

- 05 6E

- 04 2E

- 05 1E

- 05 No Data
Cattle

– Direct Applied 0.0013 2E

- 04 1E

- 05 1E

- 05 2E

- 04 7E

- 06 5E

- 06 2E

- 04 6E

- 06 4E

- 06 No Data

Poultry (Dust Box)

– Direct Applied 0.00060

(lb ai/ bird) 1,000

birds 2E

- 04 2E

- 05 1E

- 05 2E

- 04 8E

- 06 6E

- 06 2E

- 04 7E

- 06 5E

- 06 No Data

## Page 121 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Poultry (Floor Management) 0.00030

(lb ai/ sq ft) 1,000

sq ft 1E

- 04 8E

- 06 7E

- 06 1E

- 04 4E

- 06 3E

- 06 1E

- 04 4E

- 06 3E

- 06 No Data

Swine

- Bedding 0.00020 8E

- 05 5E

- 06 5E

- 06 8E

- 05 3E

- 06 2E

- 06 8E

- 05 2E

- 06 2E

- 06 No Data

Poultry (Wire Cage)

– Direct Applied 0.00010 1,000 birds 4E

- 05 3E

- 06 2E

- 06 4E

- 05 1E

- 06 1E

- 06 4E

- 05 1E

- 06 8E

- 07 No Data

(11c) Dust: Rotary Duster (Plunger Data as Surrogate) Cattle, Swine

–

Direct Applied 0.0075

(lb ai /animal) 400

animals 2E

- 03 3E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 No Data

0.0038 2E

- 03 3E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 No Data

Cattle

– Direct Applied 0.0013 2E

- 03 3E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 No Data

Poultry (Dust Box)

– Direct Applied 0.00060

lb ai/ bird 20,000

birds 2E

- 03 3E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 No Data

Poultry (Floor Management) 0.00030 20,000 sq ft 2E

- 03 3E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 No Data Poultry (Wire Cage)

– Direct Applied 0.00010 20,000 birds 2E

- 03 3E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 No Data

(11d) Dust: Plunger Duster Poultry (Dust Box)

– Direct Applied 0.00060

lb ai/ bird 1,000

birds 2E

- 03 3E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 2E

- 03 2E

- 04 2E

- 04 No Data

Poultry (Floor Management) 0.00030 1,000 sq ft 3E

- 05 5E

- 06 4E

- 06 3E

- 05 5E

- 06 4E

- 06 3E

- 05 5E

- 06 4E

- 06 No Data Poultry (Wire Cage)

– Direct Applied 0.00010 1,000 birds 8E

- 04 1E

- 04 1E

- 04 8E

- 04 1E

- 04 1E

- 04 8E

- 04 1E

- 04 1E

- 04 No Data

(12a) Paint: Brush or Roller Poultry (Roost

Paint) 0.08

lb ai/ gallon 2 gallons 3E

- 06 4E

- 07 4E

- 07 3E

- 06 4E

- 07 3E

- 07 3E

- 06 4E

- 07 3E

- 07 No Data

0.077 3E

- 06 4E

- 07 4E

- 07 3E

- 06 4E

- 07 3E

- 07 3E

- 06 3E

- 07 3E

- 07 No Data

0.064 2E

- 07 3E

- 08 3E

- 08 2E

- 07 3E

- 08 3E

- 08 2E

- 07 3E

- 08 3E

- 08 No Data

## Page 122 of 124 Table J.3. TCVP Occupational Handler Cancer Risk Estimates

– Contract/ Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/ Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

0.03 1E

- 06 1E

- 07 1E

- 07 1E

- 06 1E

- 07 1E

- 07 1E

- 06 1E

- 07 1E

- 07 No Data

(12b) Paint: Airless Poultry (Roost

Paint) 0.08

lb ai/ gallon
2 gallons 7E

- 07 3E

- 07 2E

- 07 6E

- 07 2E

- 07 2E

- 07 6E

- 07 2E

- 07 2E

- 07 No Data

0.077 7E

- 07 2E

- 07 2E

- 07 6E

- 07 2E

- 07 2E

- 07 6E

- 07 2E

- 07 2E

- 07 No Data

0.064 6E

- 08 2E

- 08 2E

- 08 5E

- 08 2E

- 08 1E

- 08 5E

- 08 1E

- 08 1E

- 08 No Data

0.03 3E

- 07 1E

- 07 9E

- 08 2E

- 07 7E

- 08 7E

- 08 2E

- 07 7E

- 08 6E

- 08 No Data
(13) Solid Feed Additive for Feed Through Applications via Cup (Granular Data as Surrogate) Horse Feed 0.0015 (lb ai/ animal) 500

horses 3E

- 09 2E

- 09 2E

- 09 2E

- 09 5E

- 10 5E

- 10 2E

- 09 3E

- 10 3E

- 10 No Data

0.00077 2E

- 09 1E

- 09 1E

- 09 1E

- 09 3E

- 10 3E

- 10 9E

- 10 2E

- 10 2E

- 10 No Data

Cattle Feed 0.0022 1,000

cows 5E

- 08 3E

- 08 3E

- 08 3E

- 08 8E

- 09 8E

- 09 3E

- 08 5E

- 09 5E

- 09 No Data

0.0017 4E

- 08 2E

- 08 2E

- 08 2E

- 08 6E

- 09 6E

- 09 2E

- 08 4E

- 09 4E

- 09 No Data

1. Inhalation exposures for exposure scenario (6) RTU Pet Collar Applications are considered negligible; therefore, the cancer risk estimates presented are from dermal exposures only. For risk management purposes, the currently labeled level of PPE and EC has been identified (bolded) for each individual expo sure scenario. 

### Table J.4. TCVP Occupational Handler Cancer Risk Estimates for Exposure Scenario 10c with Use of Chemical

- Specific Data and PHED

– Contract/Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Mixer/Loaders (10c) Wettable Powder: Mechanically

- Pressurized Handgun Beef Cattle

- Direct

Spray 0.040 400 animals No Data 1E

- 06 No Data No Data No Data No Data No Data No Data No Data No Data
Swine

- Direct Spray 0.020 No Data 5E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data Poultry (Floor Management Litter, 0.00080 20,000 sq ft No Data 5E

- 06 No Data No Data No Data No Data No Data No Data No Data No Data

## Page 123 of 124 Table J.4. TCVP Occupational Handler Cancer Risk Estimates for Exposure Scenario 10c with Use of Chemical

- Specific Data and PHED

– Contract/Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

MRID 42622301 Fowl Tick), Poultry

Droppings, Manure Piles, Garbage Piles, Under Feed Troughs Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds No Data 5E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 20,000 sq ft No Data 2E

- 06 No Data No Data No Data No Data No Data No Data No Data No Data

0.00016 No Data 1E

- 06 No Data No Data No Data No Data No Data No Data No Data No Data

0.000080 No Data 5E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data
Applicators

(10c) Wettable Powder: Mechanically

- Pressurized Handgun

MRID 42622301 Beef Cattle

- Direct

Spray 0.040 400 animals No Data 1E

- 06 No Data No Data No Data No Data No Data No Data No Data No Data
Swine

- Direct Spray 0.020 No Data 7E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft No Data 7E

- 06 No Data No Data No Data No Data No Data No Data No Data No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds No Data 7E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 20,000 sq ft No Data 3E

- 06 No Data No Data No Data No Data No Data No Data No Data No Data

0.00016 No Data 1E

- 06 No Data No Data No Data No Data No Data No Data No Data No Data

0.000080 No Data 7E

- 07 No Data No Data No Data No Data No Data No Data No Data No Data
Mixer/Loader/Applicators (10c) Wettable Beef Cattle

- Direct

Spray 0.040 400 animals 4E

- 06 2E

- 06 2E

- 06 3E

- 06 1E

- 06 8E

- 07 3E

- 06 1E

- 06 7E

- 07 No Data

## Page 124 of 124 Table J.4. TCVP Occupational Handler Cancer Risk Estimates for Exposure Scenario 10c with Use of Chemical

- Specific Data and PHED

– Contract/Commercial Exposure Scenario Crop or Target App. Rate a (lb ai/ unit) Area

Treated b (units/ day) Contract/Commercial

SL/NoG No R SL/G

NoR DL/G

No R SL/NoG

PF5 R SL/G

PF5 R DL/G

PF5 R SL/No G

PF10 R SL.G

PF10 R DL/G

PF10 R EC

Powder: Mechanically

- Pressurized Handgun

PHED Swine

- Direct

Spray 0.020 2E

- 06 1E

- 06 9E

- 07 1E

- 06 6E

- 07 4E

- 07 1E

- 06 5E

- 07 3E

- 07 No Data Poultry (Floor Management Litter, Fowl Tick), Poultry Droppings, Manure Piles, Garbage Piles, Under Feed Troughs 0.00080 20,000 sq ft 2E

- 05 1E

- 05 9E

- 06 1E

- 05 6E

- 06 4E

- 06 1E

- 05 5E

- 06 3E

- 06 No Data

Poultry (Wire Cages)

- Direct Spray 0.00040 20,000 birds 2E

- 06 1E

- 06 9E

- 07 1E

- 06 6E

- 07 4E

- 07 1E

- 06 5E

- 07 3E

- 07 No Data

Dairy Barns, Poultry Houses, Swine Barns, or other Animal Buildings 0.00032 20,000 sq ft 8E

- 06 4E

- 06 4E

- 06 6E

- 06 2E

- 06 2E

- 06 6E

- 06 2E

- 06 1E

- 06 No Data 0.00016 4E

- 06 2E

- 06 2E

- 06 3E

- 06 1E

- 06 8E

- 07 3E

- 06 1E

- 06 7E

- 07 No Data

0.000080 2E

- 06 1E

- 06 9E

- 07 1E

- 06 6E

- 07 4E

- 07 1E

- 06 5E

- 07 3E

- 07 No Data

For risk management purposes, the currently labeled level of PPE and EC has been identified (bolded) for each individual expo sure scenario.