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### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF PREVENTION, PESTICIDES AND

TOXIC SUBSTANCES

M EMORANDUM

DATE: January 7 , 2009

SUBJECT: Transmittal memo of materials for the FIFRA Scientific Advisory Panel meeting on “ Draft

Framework and Case Studies on Atrazine, Human Incidents, and the Agricultural Health Study: Incorporation of Epidemiology and Human Incident Data into Human Health Risk Assessment ” to be held February 2

- 5, 2010

FROM: Tina E. Levine, Ph.D.

Director Health Effects Division (7509P)

TO: Myrta Christian

Designated Federal Official FIFRA Scientific Advisory Panel Office of Science Coordination and Policy (7201M)

On February 2

- 5, 2010

, EPA will present its draft framework for incorporating epidemiology and human incident data into human health risk assessment along with three draft case studies to the FIFRA SAP. The purpose of this SAP meeting is to consider broad science issues associa ted with incorporating epidemiology and human incident data into human health risk assessment. In addition, t he February meeting is also one of three SAP s being held in 2010 on science issues related to human health effects of atrazine. This memorandum
t ransmits the Agency’s materials listed below for the February, 2010 meeting

. This transmission includes the draft framework paper and draft case study on ecologic and retrospective epidemiologic study designs (Case study 1)

. An overview of the draft ca se study on using data from a prospective study , the Agricultural Health Study, (Case study 2) is provided in this transmission. The draft framework

, Case study 1

, and the overview of Case study 2 are included together in a single file ( Epi

- Incident Frame work_D raft.doc ). An addendum containing more details on Case study 2 , Case study 3 on using human incident data, and the charge questions for the Panel will be provided in separate transmission s to the SAP

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Document Transmitted to SAP File Name Indi cate Whether FIFRA 10(g) or © Protected DRAFT Framework for Incorporating Human Epidemiologic & Incident Data in Health Risk Assessment, January 7, 2010 (Document includes Case study A and overview of Case study B ) Epi

- Incident Framework_Draft.doc No

Ma ttix KD, Winchester PD, and Scherer LR. 2007. Incidence of abdominal wall defects is related to surface water atrazine and nitrate levels. Journal of Pediatric Surgery; 42, 947

- 949. 

# © No

Ochoa

- Acuña H, Carbajo C. 2009. Risk of limb birth defects and m other’s home proximity to cornfields. Science of the Total Environment, 407: 4447

- 4451. 

# © No

Ochoa

- Acuña H, Frankenberger J, Hahn L, and Carbajo C. 2009. Drinking water herbicide exposure in Indiana and prevalence of small

- for

- gestational

- age and preterm delivery. Environmental Health Perspectives, 117(10): 1619

- 1624. 

# © No

Villanueva C, Durand G, Coutte M, Chevrier C, and Cordier S. 2005. Atrazine in municipal drinking water and risk of low birth weight, preterm delivery, and small

for

- gestational

- age Status. Environmental Health Perspectives, 62(6): 400

- 405. 

# © No

Winchester PD, Huskins J, and Ting J. 2009. Agrichemicals in surface water and birth defects in the United States. Acta Paediatrica, 98(4): 664

- 669. 

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Bakke, B., A.J. De Roos, D.B. B arr, P.A. Steward, A. Blair, L. Beane

- Freeman, C.F. Lynch, R.H. Allen, M.C.R. Alavanja, and R. Vemeulen. 2008. Exposure to atrazine and selected non

- persistent pesticides among corn farmers during a growing season. Journal of Exposure Science and Environm ental Epidemiology, 2008: 1

- 11. 

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Thomas K.W., Dosemeci M., Hoppin J.A., Sheldon L.S., Croghan C.W., Gordon S.M., Jones M.L., Reynolds S.J., Raymer J.H., Akland G.G., Lynch C.F., Knott C.E., Sandler D.P., Blair A.E., and Alavanja M.C.. Urinary biomark er, dermal, and air measurement results for 2,4

- D and chlorpyrifos farm applicators in the Agricultural Health Study. J Expos Sci Environ Epidemiol 2009: epub ahead of print, 25 February doi: 10.1038/jes.2009.6. 

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US EPA. 2007. Review of Worker Expos ure Assessment Methods. FlFRA Scientific Advisory Panel. ExposureSAP.Jan2007.V121206.pdf No