EXHIBIT 12.2

AMERICAN EXPRESS COMPANY 
COMPUTATION IN SUPPORT OF RATIO OF EARNINGS TO FIXED CHARGES(Dollars in millions)

|                                         |  |                                   |                           |  |      |       |      |   |       |  |   |        |  |   |       | 
|---------------------------------------- |  | --------------------------------- | ------------------------- |  | ---- | ----- | ---- | - | ----- |  | - | ------ |  | - | ----- | 
|                                         |  |                                   |                           |  |     
|                                         |  | Nine MonthsEndedSeptember 30,2010 |                           |  |     
|                                         |  |                                   | Years
 Ended December 31, | 
|                                         |  |                                   |                           | 
|                                         |  |                                   | 2009                      |  | 2008 |       | 2007 |   | 2006  | 
|                                         |  |                                   |                           |  |      |       |      |   |       |  |  
|Earnings:                                |  |                                   |                           |  |      |       |      |   |       |  |   |        |  |   |       | 
|Pretax income from continuing operations |  | $                                 | 4,487                     |  | $    | 2,841 |      | $ | 3,581 |  | $ | 5,694  |  | $ | 5,152 | 
|Interest expense                         |  |                                   | 1,818                     |  |      | 2,208 |      |   | 3,628 |  |   | 4,525  |  |   | 3,258 | 
|Other adjustments                        |  |                                   | 71                        |  |      | 129   |      |   | 144   |  |   | 143    |  |   | 139   | 
|                                         |  |                                   |                           |  |      |       |      |   |       |  |   |        |  |   |       | 
|Total earnings (a)                       |  | $                                 | 6,376                     |  | $    | 5,178 |      | $ | 7,353 |  | $ | 10,362 |  | $ | 8,549 | 
|                                         |  |                                   |                           |  |      |       |      |   |       |  |   |        |  |   |       | 
|                                         |  |                                   |                           |  |      |       |      |   |       |  |   |        |  |   |       | 
|Fixed charges:                           |  |                                   |                           |  |      |       |      |   |       |  |   |        |  |   |       | 
|Interest expense                         |  | $                                 | 1,818                     |  | $    | 2,208 |      | $ | 3,628 |  | $ | 4,525  |  | $ | 3,258 | 
|Other adjustments                        |  |                                   | 61                        |  |      | 121   |      |   | 114   |  |   | 106    |  |   | 106   | 
|                                         |  |                                   |                           |  |      |       |      |   |       |  |   |        |  |   |       | 
|Total fixed charges (b)                  |  | $                                 | 1,879                     |  | $    | 2,329 |      | $ | 3,742 |  | $ | 4,631  |  | $ | 3,364 | 
|                                         |  |                                   |                           |  |      |       |      |   |       |  |   |        |  |   |       | 
|                                         |  |                                   |                           |  |      |       |      |   |       |  |   |        |  |   |       | 
|Ratio of earnings to fixed charges (a/b) |  |                                   | 3.39                      |  |      | 2.22  |      |   | 1.96  |  |   | 2.24   |  |   | 2.54  | 
|                                         |  |                                   |                           |  |      |       |      |   |       |  |   |        |  |   |       | 

Included in
interest expense in the above computation is interest expense related to the
cardmember lending activities, international banking operations and charge card
and other activities in the Consolidated Statements of Income. Interest expense
does not include interest on liabilities recorded in accordance with GAAP
governing unrecognized tax benefits. American Express policy is to classify
such interest in income tax provision in the Consolidated Statements of Income.

For purposes
of the earnings computation, other adjustments include adding the
amortization of capitalized interest, the net loss of affiliates accounted for
under the equity method whose debt is not guaranteed by American Express, the
non-controlling interest in the earnings of majority-owned subsidiaries with
fixed charges and the interest component of rental expense and subtracting
undistributed net income of affiliates accounted for under the equity method.

For purposes
of the fixed charges computation, other adjustments include capitalized
interest costs and the interest component of rental expense.

E-3

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