Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 1 of 21 **UNITED STA**

**TES ENVIRONMENTA L PROTECTION A**  **GENCY** WA SHINGTON, D.C. 20460 **Office of Chem ical Safety and Pollution Prevention** 


### MEMORANDUM May 3 , 20 1 2
**SUBJECT: Cyprodinil** 

**–** Acute and Chronic Dietary and Drinking Water Exposure and Risk

Assessm ent. **PC Code:** 288202 **DP Barcode:** D 3 90233 & 3 98362 **Decision No** .: 447576 & 448809 **Registration No. :**  100
- 953 **Petition No.:** 1E7854 & 1E7869 **Regulatory Action:** Section 3 **Risk Assessment Type:** Dietary **Case No.:** NA **T XR No.:**  NA **CAS No :**  121552
- 61
- 2 **MRID No.:** NA **40 CFR:** 180.532 

### FROM: Thurston G. Morton, Chemist

Risk Assessment Branch IV Health Effects Division (7509 P ) **THROUGH:** Doug Dotson , Chemist

Meheret Negussie, Chemist Dietary Exposure Science Advisory Council (DESAC), and Susan Humm el, Senior Scientist, RAB IV Elissa Reaves, PhD. Branch Chief Health Effects Division (7509 P ) **TO:** Rebecca Daiss, Risk Assessor, RAB IV

Health Effects Division (7509P) and Li sa Jones/Erik Kraft, RM20 Fungicide Branch Registration Division (7505P)Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 2 of 21 This document provides an acute and chronic dietary and drinking water risk analy ses of exposures resulting from use of cy prodinil as a fungicide on food crops
. This assessment supports requests to amend the use of cy prodinil on a number of expanded crop groups, add the remaining fruiting vegetables (in addition to tomato), and to add the new use on leafy petioles subgroup 4B. Grapes are being expanded to crop subgroup 13
- 07F and strawberry to 13
- 07G. **Executive Summary** Acute and chronic dietar

y risk assessments w ere conducted for cy prodinil using the Dietary Exposure Evaluation Model ( DEEM
- FCI DTM, Version 2.03), which uses food consumption data from the USDA’s Continuing Survey s of Food Intakes by Individuals (CSFI I) from 1994
- 1996 and 1998. Acute Dietary

Exposure Analy sis Results and Characterization A conservative acute dietary exposure analy sis was performed for the general U.S. population and various population subgroups. T olerance level residues and 100 % crop treated assumptions wer e used. DEEM default and empirical processing factors were used to modify the tolerance values. The acute analy sis incorporated the 1 in 10 year peak surface drinking water estimate f rom application of cy

prodinil to grapes . The res ulting 9 5 th percentile acute exposure estimate s are not of concern for the general U.S. population or any of the other population subgroups. The subgroup with the highest risk estimate i s children 1
- 2 y ears old with a % acute population adjusted dose ( a PA D ) of 8 %. The% a PAD for the general U.S. population i s 5 %. Chronic Dietary

Exposure Analy sis Results and Characterization A moderately

refined chronic dietary

exposure analy sis was performed for the general U.S. population and various population su bgroups. For the chronic dietary analy sis, tolerance level residues for most commodities; average field trial residues for pome fruit, head lettuce, leaf lettuce, and grapes; and 100% crop treated assumptions were used. DEEM default and empirical process ing factors were used to modify the tolerance values. The chronic analy sis incorporated the 10 y ear average surface drinking water estimate from application of cy prodinil to grapes . Chronic dietary

risk estimates are not of concern for the general U.S. p opulation or any of the other population subgroups. The subgroup with the highest risk estimate i s children 1
- 2 y ears old with a % chronic PAD ( cPAD ) of 7 5 %. The% cPAD for the general U.S. population i s 2 8 %. **I. Introduction**  Dietary risk assessment inc orporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects)
. This dose is referred to as the PAD. The PAD is equivalent to the point of departure (POD,Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 3 of 21 NOAEL, LOAEL, etc) divided by the required uncertainty

or safety factors
. For acute and non
- cancer chronic exposures, HED is concerned when estimated dietary ri sk exceeds 100 % of the PAD. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA_PEST/2000/July /Day _12/6061.pdf ; or see SOP 99.6 (8/20/99). **II. Residue Information**  Residues of Concern The metabolism of cy

prodinil has been studied in apple, peach, potato, tomato, and wheat. The residue of concern in plants is the parent compound cy prodinil as determined by the HED Metabolism Assessment Review Committee (MARC) (D243198, G. Kramer, 3/11/98). The nature of the residue in rum inants is adequately understood based on acceptable lactating goat metabolism studies. HED has concluded that the residues of concern for both risk assessment and the tolerance definition should include the combined residues of cy prodinil and free and con jugated CGA
- 304075, expressed in parent equivalents (D345970 and D345182, G. Kramer, 6/4/08). The water residue s of concern as determined by MARC are the parent and CGA 249287 (4
- cyclopropyl
- 6
- methylpy rimidin
- 2
- amine) (D292557, 6/8/03). HED continues to consider these metabolites and degradates to be the residues of concern. **Table 1**  **: Summ**  **ary of Residues of Concern**  **for Cyprodini**  **l Matrix**  **Residues of Concern For Risk Assessm**  **ent For Tolerance Expression**  Plants cyprodinil cyprodinil Livestock cyprodi nil and CGA
- 304075 cyprodinil and CGA
- 304075 Water cyprodinil and CGA 249287 cyprodinil 

### Established/Recommended Tolerances Permanent tolerances are established (40 CFR §180.532(a)) for residues of cy prodinil per se in/on a variety

of crop commodities, at levels ranging from 0.02 ppm in/on almonds to 340 ppm in citrus oil. Recommended tolerances for the proposed amended /new u se s are as follows ( D 389554 , T
. Morton , 0 5 / 3 //201 2 )
.Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 4 of 21 Onion, bulb , subgroup 3
- 07A.....
................................ ................................ 0.6 ppm Onion, green , subgroup 3
- 07B
................................ ................................ ..... 4 .0 ppm Caneberry subgroup 13
- 07A.....................
............... ...................10 ppm Bushberry subgroup 13
- 07B
................................ ............................ .........3.0 ppm F ruit , s mall vine climbing , except fuzzy kiwifruit , subgroup 13
- 07F,
... .....2.0 ppm B erry , l ow

grow ing subgroup 13
- 07G, except cranberry
............................. 5.0 ppm Dragon fruit
................................ ................................ ................................ 2.0 ppm Fruit, pome, group 11
- 10
................................ ................................ ............. 1.7 ppm Vegetable, fruiting, group 8
- 10
................................ ................................ .... 1. 5 ppm Vegetable, leafy, except brassica, subgroup 4A..................
..................... 5 0 ppm Leafy petiole subgroup 04B
................................ ................................ ....... 30 ppm Citrus, oil...................................................
.................. ..........60 ppm 

### HED continues to recommend that the current tolerance expression for animal commodities be changed to reflect both parent and metabolite CGA
- 304075 ( 4
- [(4
- cyclopropyl
- 6
- methyl
- 2
- 2
- py rimidinyl)amino]
- phenol ). Residues U sed in the Acute and Chronic Analy sis For the acute dietary

analy sis, tolerance level residues and 100% crop treated assumptions were used for all treated commodities
. For the chronic dietary analy sis, tolerance level residues for most commodities; average field trial residues for pome fruit, head lettuce, leaf lettuce, spinach, tomato, lemon, and grapes; and 100% crop treated assumptions were used. Default processing factors were used for most processed commodities , except for tomato paste /puree in the chronic( 1x ) and lemon/lime juice (1x) . R esidues used in the acute and chronic dietary analy s i s are provided in Table 2
. Average residues where noted were used in the chronic dietary analy sis.Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 5 of 21 **Table 2. Residue Estim**  **ates Used in the Cyprodinil**  **Acute and Chronic Dietary**  **/ Drinking Water Analys**  **i s**  **Com mo**  **dity Tolerance (ppm**  **)** Crop Subgroup 1B , except sugarbeet 0.75 Crop Group 2 10 Onion , bulb subgroup 3
- 07A 0.6 Onion, green subgroup 3
- 07B 4.0 Crop Subgroup 4A (except spinach) 30 tolerance/0.87 avg head lettuce 30 tolerance/1 3 avg leaf lettuc e Crop Subgroup 4 B 30 Crop Subgroup 5A Head and stem 1.0 Crop Subgroup 5B Leafy Brassica greens 10 Bean, dry; Bean, succulent 0.6 Vegetable, fruiting, group 8
- 10 1. 5 Crop Group 9 0.7 Lemon, Lime 0.6 Citrus Oil Decreased to 60 Pom e fruit , Crop gr oup 11
- 10 1.7 tolerance/0.50 avg apple 1.7 tolerance/0.38 avg pear Stone fruit , Crop group 12 2 Caneberry , s ubgroup 13
- 07A 10 Bushberry s ubgroup 13
- 07 B 3 Small fruit vine climbing subgroup 13
- 07F, except fuzzy kiwifruit 2.0 tolerance/0.81 avg grapes L ow grow ing berry subgroup 13
- 07G, except cranberry 5.0 (inc. straw berry) Almond 0.02 Pistachio 0.1 Crop Subgroup 19A Herb Fresh (except parsley) 3 Crop Subgroup 19A Herb Dried (except parsley) 15 Parsley, dried leaves 170 Parsley leaves 35 Rape seed oil (canola, seed) 0.03 Avocado, Canistel ; Mango ; Papaya ; Sapodilla ; Sapote, black; Sapote, mamey; Star apple 1.2 Dragonfruit 2.0 Kiwifruit 1.8 Watercress 20 Beef, Goat, Horse, Sheep, meat byproducts (includ ing liver and kidney ) 0.02 Grape, raisin 3.0 Turnip, greens 10.0 

### III. **Water Data** Drinking water residues were incorporated directly into the acute and chronic dietary analy s e s as “water, direct, all sources” and “water, indirect, all sources” and wer e provided by the Environmental Fate and Effects Division ( EFED ) ( D 3 91853 , J Melendez 11 / 4 / 1 1 ). EFED generated the surface water estimates using the linked Pesticide Root Zone/Exposure Analy sis Modeling Sy stem ( PRZM
- EXAMS ) T ier 2 aquatic models. G round w ater estimates were calculated using the Tier 1 S creening C oncentration In GRO und W ater ( SCI
- GROW) model.Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 6 of 21 Estimated Drinking Water Concentrations (EDWCs) for cy prodinil and its metabolite CGA
249287 were derived based on a maximum a pplication rate of 0.47 lb a.i./A applied 3 times/year, or 1.4 lb a.i./A/y ear, on grapes . The concentrations have been adjusted with the Percent Crop Area (PCA) of 0.87 for a national assessment. Combined s urface water EDWCs for cy prodinil and CGA
- 24928 7 used in the exposure assessment, are provided in Table 3
. **Table 3. EDWCs for the Cyprodinil Hum an Health Risk Assessm**  **ent Drinking Water Source**  **Peak (μg/L) Annual Mean**  **(μg/L)** Surface Water 3 4. 79 2 4.65 Ground Water 0. 0861 0. 0861 

### IV. **DEEM -**  **FCIDTM Program and Consumption Information**  Cy prodinil chronic dietary

exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM
- FCI DTM, Version 2.03), which incorporates consumption data from USDA’s Continuing Survey s of Food Intakes by Individuals (CSFI I), 1994
- 1996 and 1998. The 1994
- 96, 98 data are based on the reported consumption of more than 20,000 individuals over two non
- consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA
- defined food commodities (e.g. apples, peeled fruit
- cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic ex posure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on analy sis of the 1994
- 96, 98 CSFI I consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1
- 2, children 3
- 5, children 6
- 12, youth 13
- 19, adults 20
- 49, females 13
- 49, and adults 50+ y ears old. For chronic dietary

exposure assessment, an estimate of the residue level in each food or food
form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily

consumption estimate for that food/food form. The resulting residue consumption estimate for each food/food form is summed with the residue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day

and as a percent of the cPAD. This procedure is performed for each population subgroup.Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 7 of 21 **V. Toxicological Information**  HED evaluated the toxicology data base for cy

p rodinil and selected doses and endpoints for chronic dietary and drinking water risk assessments provided in Table 4
. **Table 4. Sum ma**  **ry of Toxicological Doses and Endpoints for Cyprodinil for Use in Dietary Hum an Health Risk Assessm**  **ents Exposure/Scen**  **ario Point of**  **Departure Uncertainty/F** 

**QPA Safety Factors**  **RfD, PAD, LOC**

**for Risk Assessment**  **Study and Toxicological Effects** Acute Dietary (All Populations) NOAEL = 20 0 mg/kg/day UF A = 10x

UF H =10x FQPA SF= 1x Acute RfD = 2.0

mg/kg/day aPAD = 2 .0 mg/kg/day Acute Neurotoxicity
- Rat

LOAEL = 600 mg/kg/day based on clinical signs of toxicity, low motor activity and reversible hypothermia
Chronic Dietary (All Populations) NOAEL= 2.7 mg/kg/day UF A = 10x

UF H =10x FQPA SF= 1x Chronic RfD =

0.0 27 mg/kg/day cPAD = 0.0 27 mg/kg/day 2
- Year Chronic Toxicity/ Carcinogenicity
- rat

LOAEL = 35.6 mg/kg/day based on degenerative liver lesions (spongiosis hepatis) in males. Cancer (all routes) Classification: “Not likely to be carcinogenic to humans”

Point o f Departure (POD) = A data point or an estimated point that is derived from observed dose
- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LO AEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. 

### VI. **Results/Discussion** As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM
- FCI DTM analy ses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table s 5 & 6 are for the general U.S. Population, all infants (<1 year old), children 1
- 2, children 3
- 5, children 6
- 12, you th 13
- 19, females 13
- 49, adults 20
- 49, and adults 50+ y ears. Results of Acute Dietary

Exposure Analy sis The results of the acute dietary exposure analy sis are reported in Table 5.Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 8 of 21 **Table 5**  **: Sum ma**  **ry of Acute Dietary Exposure and Risk for Cyprodini**  **l Population Subgroup**  **a PAD (m**  **g/kg/day) Acute (9**  **5 th Percentile)**  **Exposure (m g/kg/day)**  **%aPAD** General U.S. Population

2.0 0.0 9 5 794 4.8 All Infants (< 1 year old) 0. 10 2 882 5 .1 Children 1
- 2 years old 0. 1 51445 7 .6 Children 3
- 5 years old 0. 13 1883 6.6 C hildren 6
- 12 years old 0.0 9 8193 4.9 Youth 13
- 19 years old 0.0 80270 4 .0 Adults 20
- 49 years old 0.0 9 2162 4.6 Adults 50+ years old 0.0 85 400 4 .3 Females 13
- 49 years old 0.0 99 465 5 .0 

### Results of Chronic Dietary Exposure Analy sis The results of the chronic dietary exposure analy sis are reported in T able 6
. **Table 6**  **: Sum ma**  **ry of Chronic Dietary Exposure and Risk for Cyprodinil**  **Population Subgroup cPAD (m**  **g/kg/day) Chronic**  **Exposure (m g/kg/day)**  **% cPAD**  General U.S. Population

0.0 27 0.0 07 421 2 8 All Infants (< 1 year old) 0.0 14 099 52 Children 1
- 2 years old 0. 0 202 69 7 5 Children 3
- 5 years old 0.0 1 514 8 5 6 Children 6
- 12 years old 0.0 08 5 52 3 2 Youth 13
- 19 years old 0.0 0 51 95 19 Adults 20
- 49 years old 0.0 0 5 818 2 2 Adults 50+ years old 0.0 0 7 2 60 27 Females 13
- 49 years old 0.0 0 60 6 6 2 3 

### VII. Characterization of Inputs/Outputs For the acute dietary

analy sis, tolerance level residues and 100% crop treated assumptions were used for all treated commodities
. For the chronic dietary analy sis, toleranc e level residues for most commodities ; average field trial residues for pome fruit, head lettuce, leaf lettuce, spinach, tomatoes, lemon, and grapes; and 100% crop treated assumptions were used. Default processing factors were used for all processed commo dities except tomato paste /puree ( 1 x) and and lemon/lime juice (1x). Residues do not warrant further refinement at this time. **V I**  **II. Conclusions**  An acute and chronic dietary exposure analy ses was performed for the general U.S. population and various popu lation subgroups
. The acute and chronic risk estimates are below HED’s level of concern. HED is confid ent the acute and chronic dietary exposures to cy

prodinil are not underestimated.Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 9 of 21 **IX .**  **List of Attachments** 1. Acute DEEM
- FCI D Residue Input File. 2. Results of Acute DEEM
- FCI D Dietary Exposure Analy sis. 3. Chronic DEEM
- FCI D Residue Input File. 4. Results of Chronic DEEM
- FCI D Dietary Exposure Analy sis.Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 10 of 21 Attachment 1 Acute DEEM
- FCI D Residue Input File
Filename: C: \ Documents and Settings \ tmorton \ My Do cuments \ MyFiles \ DEEM Files \ 288202 Cyprodinil \ Leafy Petioles 1E7869 and Misc 1E7854 \ 288202acuteEPArecommendations.R98 Chemical: cyprodinil RfD(Chronic): .03 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 2 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 03

- 13
- 2012/10:38:56/8 Program ver. 2.03

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 01010500 1AB Beet, garden, roots 0.750000 1.000 1.000 01010501 1AB Beet, garden, roots
- babyfoo d 0.750000 1.000 1.000 01010670 1AB Burdock 0.750000 1.000 1.000 01010780 1AB Carrot 0.750000 1.000 1.000 01010781 1AB Carrot
- babyfood 0.750000 1.000 1.000 01010790 1AB Carrot, juice 0.750000 1.000 1.000 01010840 1AB Celeriac 0.750000 1.000 1.000 01011000 1AB Chicory, roots 0.750000 1.000 1.000 01011680 1AB Ginseng, dried 0.750000 1.000 1.000 01011900 1AB Horseradish 0.750000 1.000 1.000 01012500 1AB Parsley, turnip rooted 0.750000 1.000 1.000 01012510 1AB Parsnip 0.750000 1.000 1.000 01012511 1AB Parsnip
- babyfood 0.750000 1.000 1.000 01013140 1AB Radish, roots 0.750000 1.000 1.000 01013160 1AB Radish, Oriental, roots 0.750000 1.000 1.000 01013270 1AB R utabaga 0.750000 1.000 1.000 01013310 1AB Salsify, roots 0.750000 1.000 1.000 01013880 1AB Turnip, roots 0.750000 1.000 1.000 02000510 2 Beet, garden, tops 10.000000 1.000 1.000 02001010 2 Chicory, tops 10.000000 1.000 1.000 02001400 2 Dasheen, leaves 10.000000 1.000 1.000 02003150 2 Radish, tops 10.000000 1.000 1.000 02 003170 2 Radish, Oriental, tops 10.000000 1.000 1.000 02003320 2 Salsify, tops 10.000000 1.000 1.000 03001640 3 Garlic 0.600000 1.000 1.000 03001650 3 Garlic, dried 0.600000 1.000 1.000 03001651 3 Garlic, dried
- babyfood 0.600000 1.000 1.000 03001980 3 Leek 4.000000 1.000 1.000 03002370 3 Onion, dry bulb 0.600000 1.00 0 1.000 03002371 3 Onion, dry bulb
- babyfood 0.600000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.600000 9.000 1.000 03002381 3 Onion, dry bulb, dried
- babyfood 0.600000 9.000 1.000 03002390 3 Onion, green 4.000000 1.000 1.000 03003380 3 Shallot 4.000000 1.000 1.000 04010050 4A Amaranth, leafy 50.000000 1.000 1.000 04010180 4A Arugula 50. 000000 1.000 1.000 04011040 4A Chrysanthemum, garland 50.000000 1.000 1.000 04011330 4A Cress, garden 50.000000 1.000 1.000 04011340 4A Cress, upland 50.000000 1.000 1.000 0401138 0 4A Dandelion, leaves 50.000000 1.000 1.000 04011500 4A Endive 50.000000 1.000 1.000 04012040 4A Lettuce, head 50.000000 1.000 1.000 04012050 4A Lettuce, leaf 50.000000 1.000 1.000 04012480 4A Parsley, leaves 50.000000 1.000 1.000 04013130 4A Radicchio 50.000000 1.000 1.000 04013550 4A Spinach 50.000000 1.000 1. 000 04013551 4A Spinach
- babyfood 50.000000 1.000 1.000 04020760 4B Cardoon 30.000000 1.000 1.000 04020850 4B Celery 30.000000 1.000 1.000 04020851 4B Celery
- baby food 30.000000 1.000 1.000 04020860 4B Celery, juice 30.000000 1.000 1.000 04020870 4B Celtuce 30.000000 1.000 1.000 04021520 4B Fennel, Florence 30.00000 0 1.000 1.000 04023220 4B Rhubarb 30.000000 1.000 1.000 04023670 4B Swiss chard 30.000000 1.000 1.000 05010610 5A Broccoli 1.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 11 of 21 05010611 5A Broccoli
- babyfood 1.000000 1.000 1.000 05010620 5A Broccoli, Chinese 1.000000 1.000 1.000 05010640 5A Brussels sprouts 1.000000 1.000 1.000 05010690 5A Cabbage 1.000000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 1.000000 1.000 1.000 05010720 5A Cabbage, Chinese, mustard 1.000000 1.000 1.000 05010830 5A Cauliflower 1.000000 1.000 1.000 05011960 5A Kohlrabi 1.000000 1.000 1.000 05020630 5B Broccoli raab 10.000000 1.000 1.000 05020700 5B Cabbage, Chinese, bok choy 10.000000 1.000 1.000 05021170 5B Collards 10.000000 1.000 1.000 05021940 5B Kale 10.000000 1.000 1.000 05022290 5B Mustard greens 10.000000 1.000 1.000 05023180 5B Rape greens 10.000000 1 .000 1.000 05023890 5B Turnip, greens 10.000000 1.000 1.000 06020310 6B Bean, broad, succulent 0.600000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.600000 1.000 1.000 06020370 6B Bea n, lima, succulent 0.600000 1.000 1.000 06030300 6C Bean, black, seed 0.600000 1.000 1.000 06030320 6C Bean, broad, seed 0.600000 1.000 1.000 06030340 6C Bean, cowpea, seed 0.600000 1.000 1.000 06030350 6C Bean, great northern, seed 0.600000 1.000 1.000 06030360 6C Bean, kidney, seed 0.600000 1.000 1.000 06030380 6C Bean, lima, seed 0.600000 1.000 1.000 0603 0390 6C Bean, mung, seed 0.600000 1.000 1.000 06030400 6C Bean, navy, seed 0.600000 1.000 1.000 06030410 6C Bean, pink, seed 0.600000 1.000 1.000 06030420 6C Bean, pinto, seed 0.600000 1.000 1.000 06030980 6C Chickpea, seed 0.600000 1.000 1.000 06030981 6C Chickpea, seed
- babyfood 0.600000 1.000 1.000 06030990 6C Chickpea, flour 0.600000 1.000 1.000 06031820 6C Guar, seed 0.600000 1.000 1.000 06031821 6C Guar, seed
- babyfood 0.600000 1.000 1.000 06032030 6C Lentil, seed 0.600000 1.000 1.000 08001480 8 Eggplant 1.500000 1.000 1.000 08002340 8 Okra 1.500000 1.000 1.000 08002700 8 Pepper, bell 1.500000 1.000 1.000 08002701 8 Pepper, bell
- babyfood 1.50 0000 1.000 1.000 08002710 8 Pepper, bell, dried 1.500000 1.000 1.000 08002711 8 Pepper, bell, dried
- babyfood 1.500000 1.000 1.000 08002720 8 Pepper, nonbell 1.500000 1.000 1.000 08002721 8 Pepper, nonbell
- babyfood 1.500000 1.000 1.000 08002730 8 Pepper, nonbell, dried 1.500000 1.000 1.000 08003740 8 Tomatillo 1.500000 1.000 1.000 08003750 8 Tomato 1.500000 1.000 1.000 08003751 8 Tomato
- babyfood 1.500000 1.000 1.000 08003760 8 Tomato, paste 1.500000 1.000 1.000 08003761 8 Tomato, paste
- babyfood 1.500000 1.000 1.00 0 08003770 8 Tomato, puree 1.500000 1.000 1.000 08003771 8 Tomato, puree
- babyfood 1.500000 1.000 1.000 08003780 8 Tomato, dried 1.500000 14.300 1.000 08003781 8 Tomato, dried
- babyfood 1.500000 14.300 1.000 08003790 8 Tomato, juice 1.500000 1.000 1.000 09010750 9A Cantaloupe 0.700000 1.000 1.000 09010800 9A Casaba 0.700000 1.000 1.000 09011870 9A Honeydew melon 0.700000 1.000 1.000 09013990 9A Watermelon 0.700000 1.000 1.000 09014000 9A Watermelon, juice 0.700000 1.000 1.000 09020210 9B Balsam pear 0.700000 1.000 1.000 09020880 9B Chayote, fruit 0.700000 1.000 1.000 09021020 9B Chinese waxgourd 0.700000 1.000 1.000 09021350 9B Cucumber 0.700000 1.000 1.000 09023080 9B Pumpkin 0.700000 1.000 1.000 09023090 9B Pumpkin, seed 0.700000 1.000 1.000 09023560 9B Squash, summer 0.700000 1.000 1.000 0 9023561 9B Squash, summer
- babyfood 0.700000 1.000 1.000 09023570 9B Squash, winter 0.700000 1.000 1.000 09023571 9B Squash, winter
- babyfood 0.700000 1.000 1.000 10001080 10 Citrus, oil 60.000000 1.000 1.000 10001990 10 Lemon 0.600000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 12 of 21 10002000 10 Lemon, juice 0.600000 1.000 1.000 10002001 10 Lemon, juice
- babyfood 0.600000 1.0 00 1.000 10002010 10 Lemon, peel 0.600000 1.000 1.000 10002060 10 Lime 0.600000 1.000 1.000 10002070 10 Lime, juice 0.600000 1.000 1.000 10002071 10 Lime, juice
- babyfood 0.600000 1.000 1.000 11000070 11 Apple, fruit with peel 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11000080 11 Apple, peeled fruit 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11000081 11 Apple, peeled fruit
- babyfood 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11000090 11 Apple, dried 1.700000 8.000 1.000 PP#0F7

Full comment: PP#0F7 696 11000091 11 Apple, dried
- babyfood 1.700000 8.000 1.000 PP#0F7

Full comment: PP#0F7696 11000100 11 Apple, juice 1.700000 1.300 1.000 PP#0F7

Full comment: PP#0F7696 11000101 11 Apple, j uice
- babyfood 1.700000 1.300 1.000 PP#0F7

Full comment: PP#0F7696 11000110 11 Apple, sauce 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11000111 11 Apple, sauce
- babyfood 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11001290 11 Crabapple 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11002100 11 Loquat 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11002660 11 Pear 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11002661 11 Pear
- babyfood 1.700000 1.000 1.000 PP#0F7

Full comm ent: PP#0F7696 11002670 11 Pear, dried 1.700000 6.250 1.000 PP#0F7

Full comment: PP#0F7696 11002680 11 Pear, juice 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11002681 11 Pear, juice
- babyfood 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11003100 11 Quince 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 12000120 12 Apricot 2.000000 1.000 1.000 12000121 12 Apricot
- babyfood 2.000000 1.000 1.000 12000130 12 Apricot, dried 2.000000 6.000 1.000 12000140 12 Apricot, juice 2.000000 1.000 1 .000 12000141 12 Apricot, juice
- babyfood 2.000000 1.000 1.000 12000900 12 Cherry 2.000000 1.000 1.000 12000901 12 Cherry
- babyfood 2.000000 1.000 1.000 12000910 12 Cherry, ju ice 2.000000 1.500 1.000 12000911 12 Cherry, juice
- babyfood 2.000000 1.500 1.000 12002300 12 Nectarine 2.000000 1.000 1.000 12002600 12 Peach 2.0000 00 1.000 1.000 12002601 12 Peach
- babyfood 2.000000 1.000 1.000 12002610 12 Peach, dried 2.000000 7.000 1.000 12002611 12 Peach, dried
- babyfood 2.000000 7.000 1.000 12002620 12 Peach, juice 2.000000 1.000 1.000 12002621 12 Peach, juice
- babyfood 2.000000 1.000 1.000 12002850 12 Plum 2.000000 1.000 1.000 12002851 12 Plum
- babyfood 2.000000 1.000 1.000 12002860 12 Plum, prune, fresh 2.000000 1.000 1.000 12002861 12 Plum, prune, fresh
- babyfood 2.000000 1.000 1.000 12002870 12 Plum, prune, dried 2.000000 5.000 1.000 12002871 12 Plum, prune, dried
- babyfood 2.000000 5.000 1.000 12002880 12 Plum, prune, juice 2.000000 1.400 1.000 12002881 12 Plum, prune, juice
- babyfood 2.000000 1.400 1.000 13010550 13A Blackberry 10.000000 1.000 1.000 13010560 13A Blackberry, juice 10.000000 1.000 1.000 13010561 13A Blackberry, juice
- babyfood 10.000000 1.000 1.000 13010580 13A Boysenberry 10.000000 1.000 1.000 13011420 13A Dewberry 10.000000 1.000 1.000 13012080 13A Loganberry 10.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 13 of 21 13013200 13A Raspberry 10.000000 1.000 1.000 13013201 13A Ra spberry
- babyfood 10.000000 1.000 1.000 13013210 13A Raspberry, juice 10.000000 1.000 1.000 13013211 13A Raspberry, juice
- babyfood 10.000000 1.000 1.000 13020570 13B Blueberry 3.000000 1.000 1.000 13020571 13B Blueberry
- babyfood 3.000000 1.000 1.000 13021360 13B Currant 3.000000 1.000 1.000 13021370 13B Currant, dried 3.000000 1.000 1.000 130 21490 13B Elderberry 3.000000 1.000 1.000 13021740 13B Gooseberry 3.000000 1.000 1.000 13021910 13B Huckleberry 3.000000 1.000 1.000 14000030 14 Almond 0.020000 1.000 1.000 14000031 14 Almond
- babyfood 0.020000 1.000 1.000 14000040 14 Almond, oil 0.020000 1.000 1.000 14000041 14 Almond, oil
- babyfood 0.020000 1.000 1.000 14002820 14 Pistachio 0.100000 1.000 1.000 19010280 19A Basil, fresh leaves 3.000000 1.000 1.000 19010281 19A Basil, fresh leaves
- babyfood 3.000000 1.000 1.000 19010290 19A Basil, dried leaves 15.000000 1.000 1.000 19010291 19A Basil, dried leaves
- babyfood 15.000000 1.000 1.000 19011030 19A Chive 3.000000 1.000 1.000 19011180 19A Coriander, leaves 3.0 00000 1.000 1.000 19011181 19A Coriander, leaves
- babyfood 3.000000 1.000 1.000 19011440 19A Dillweed 3.000000 1.000 1.000 19011840 19A Herbs, other 3.000000 1.000 1.000 19011841 19A Herbs, other
- babyfood 3.000000 1.000 1.000 19012020 19A Lemongrass 3.000000 1.000 1.000 19012200 19A Marjoram 3.000000 1.000 1.000 19012201 19A Marjoram
- babyfood 3.000000 1.000 1.000 19012490 19A Parsley, dried leaves 170.000000 1.000 1.000 19012491 19A Parsley, dried leaves
- babyfood 170.000000 1.000 1.000 19013340 19A Savory 3.000000 1.000 1.0 00 20003190 20 Rapeseed, oil 0.030000 1.000 1.000 20003191 20 Rapeseed, oil
- babyfood 0.030000 1.000 1.000 21000460 M Beef, meat byproducts 0.020000 1.000 1.000 21000461 M Beef, meat b yproducts
- babyfood 0.020000 1.000 1.000 21000480 M Beef, kidney 0.020000 1.000 1.000 21000490 M Beef, liver 0.020000 1.000 1.000 21000491 M Beef, liver
- babyfood 0.020000 1.000 1.000 23001700 M Goat, meat byproducts 0.020000 1.000 1.000 23001720 M Goat, kidney 0.020000 1.000 1.000 23001730 M Goat, liver 0.020000 1.000 1.000 26003400 M Sheep, meat byproducts 0.020000 1.000 1.000 26003420 M Sheep, kidney 0.020000 1.000 1.000 26003430 M Sheep, liver 0.020000 1.000 1.000 86010000 O Water, direct, all sources 0.034790 1.000 1.000 86020000 O Water, indirect, all sources 0.034790 1.000 1.000 95000200 O Avocado 1.200000 1.000 1.000 95000740 O Canistel 1.200000 1.000 1.000 95001750 O Grape 2.000000 1.000 1.000 95001760 O Grape, juice 2.000000 1.200 1.000 95001761 O Grape, juice
- babyfood 2.000000 1.200 1.000 95001770 O Grape, leaves 2.000000 1.000 1.000 95001780 O Grape, raisin 3.000000 1.000 1.000 95001790 O Grape, wine and sherry 2.000000 1.000 1.000 95001950 O Kiwifruit 1.800000 1. 000 1.000 95002090 O Longan 2.000000 1.000 1.000 95002110 O Lychee 2.000000 1.000 1.000 95002120 O Lychee, dried 2.000000 1.850 1.000 95002150 O Mang o 1.200000 1.000 1.000 95002151 O Mango
- babyfood 1.200000 1.000 1.000 95002160 O Mango, dried 1.200000 1.000 1.000 95002170 O Mango, juice 1.200000 1.000 1.000 95002171 O Mango, juice
- babyfood 1.200000 1.000 1.000 95002450 O Papaya 1.200000 1.000 1.000 95002451 O Papaya
- babyfood 1.200000 1.000 1.000 95002 460 O Papaya, dried 1.200000 1.800 1.000 95002470 O Papaya, juice 1.200000 1.500 1.000 95003330 O Sapote, Mamey 1.200000 1.000 1.000 95003510 O Spanish lime 2.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 14 of 21 95003590 O Strawberry 5.000000 1.000 1.000 95003591 O Strawberry
- babyfood 5.000000 1.000 1.000 95003600 O Strawberry, juice 5.000000 1.000 1.000 95003601 O Strawberry, juice
- babyfood 5.000000 1.000 1.000 95003980 O Watercress 20.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 15 of 21 Attachment 2 Chronic DEEM
- FCI D Resi due Input File
Filename: C: \ Documents and Settings \ tmorton \ My Documents \ MyFiles \ DEEM Files \ 288202 Cyprodinil \ Leafy Petioles 1E7869 and Misc 1E7854 \ 288202chronicEPArecommendations.R98 Chemical: cyprodinil RfD(Chronic): .03 mg/kg bw/day NOEL(Chronic): 0 m g/kg bw/day RfD(Acute): 1.5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 03

- 13
- 2012/10:58:02/8 Program ver. 2.03

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 01010500 1AB Beet, garden, roots 0.750000 1.000 1.000 01010501 1AB Beet, garden, roots
- babyfood 0.750000 1.000 1.000 01010670 1AB Burdock 0.750000 1.000 1.000 01010780 1AB Carrot 0.750000 1.000 1.000 01 010781 1AB Carrot
- babyfood 0.750000 1.000 1.000 01010790 1AB Carrot, juice 0.750000 1.000 1.000 01010840 1AB Celeriac 0.750000 1.000 1.000 01011000 1AB Chicory, roots 0.750000 1.000 1.000 01011680 1AB Ginseng, dried 0.750000 1.000 1.000 01011900 1AB Horseradish 0.750000 1.000 1.000 01012500 1AB Parsley, turnip rooted 0.750000 1.00 0 1.000 01012510 1AB Parsnip 0.750000 1.000 1.000 01012511 1AB Parsnip
- babyfood 0.750000 1.000 1.000 01013140 1AB Radish, roots 0.750000 1.000 1.000 01013160 1AB Radish , Oriental, roots 0.750000 1.000 1.000 01013270 1AB Rutabaga 0.750000 1.000 1.000 01013310 1AB Salsify, roots 0.750000 1.000 1.000 01013880 1AB Turnip, roots 0. 750000 1.000 1.000 02000510 2 Beet, garden, tops 10.000000 1.000 1.000 02001010 2 Chicory, tops 10.000000 1.000 1.000 02001400 2 Dasheen, leaves 10.000000 1.000 1.000 0200315 0 2 Radish, tops 10.000000 1.000 1.000 02003170 2 Radish, Oriental, tops 10.000000 1.000 1.000 02003320 2 Salsify, tops 10.000000 1.000 1.000 03001640 3 Garlic 0.600000 1.000 1.000 03001650 3 Garlic, dried 0.600000 1.000 1.000 03001651 3 Garlic, dried
- babyfood 0.600000 1.000 1.000 03001980 3 Leek 4.000000 1.000 1. 000 03002370 3 Onion, dry bulb 0.600000 1.000 1.000 03002371 3 Onion, dry bulb
- babyfood 0.600000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.600000 9.000 1.000 03002381 3 Onion, dry bulb, dried
- babyfood 0.600000 9.000 1.000 03002390 3 Onion, green 4.000000 1.000 1.000 03003380 3 Shallot 4.000000 1.000 1.000 04010050 4A Amaranth, leafy 50.00000 0 1.000 1.000 04010180 4A Arugula 50.000000 1.000 1.000 04011040 4A Chrysanthemum, garland 50.000000 1.000 1.000 04011330 4A Cress, garden 50.000000 1.000 1.000 04011340 4A Cress, upland 50.000000 1.000 1.000 04011380 4A Dandelion, leaves 50.000000 1.000 1.000 04011500 4A Endive 50.000000 1.000 1.000 04012040 4A Lettuce, head 0.870000 1.000 1.000 04012050 4A Lettuce, leaf 13.000000 1.000 1.000 04012480 4A Parsley, leaves 35.000000 1.000 1.000 04013130 4A Radicchio 50.000000 1.000 1.000 04013550 4A Spinach 11.800000 1.000 1.000 04013551 4A Spinach
- babyfood 11.800000 1.000 1.000 04020760 4B Cardoon 30.000000 1.000 1.000 04020850 4B Celery 30.000000 1.000 1.000 04020851 4B Celery
- babyfood 30.000000 1.000 1.000 04020860 4B Celery, juice 30.000000 1.000 1.000 04020870 4B Celtuce 30.000000 1 .000 1.000 04021520 4B Fennel, Florence 30.000000 1.000 1.000 04023220 4B Rhubarb 30.000000 1.000 1.000 04023670 4B Swiss chard 30.000000 1.000 1.000 05010610 5A Bro ccoli 1.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 16 of 21 05010611 5A Broccoli
- babyfood 1.000000 1.000 1.000 05010620 5A Broccoli, Chinese 1.000000 1.000 1.000 05010640 5A Brussels sprouts 1.000000 1.000 1.000 05010690 5A Cabbage 1.000000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 1.000000 1.000 1.000 05010720 5A Cabbage, Chinese, mustard 1.000000 1.000 1.000 0501 0830 5A Cauliflower 1.000000 1.000 1.000 05011960 5A Kohlrabi 1.000000 1.000 1.000 05020630 5B Broccoli raab 10.000000 1.000 1.000 05020700 5B Cabbage, Chinese, bok choy 10.000000 1.000 1.000 05021170 5B Collards 10.000000 1.000 1.000 05021940 5B Kale 10.000000 1.000 1.000 05022290 5B Mustard greens 10.000000 1.000 1.000 05023180 5B Rape greens 10.000000 1.000 1.000 05023890 5B Turnip, greens 10.000000 1.000 1.000 06020310 6B Bean, broad, succulent 0.600000 1.000 1.000 06020330 6B Bean, co wpea, succulent 0.600000 1.000 1.000 06020370 6B Bean, lima, succulent 0.600000 1.000 1.000 06030300 6C Bean, black, seed 0.600000 1.000 1.000 06030320 6C Bean, broad, seed 0.60 0000 1.000 1.000 06030340 6C Bean, cowpea, seed 0.600000 1.000 1.000 06030350 6C Bean, great northern, seed 0.600000 1.000 1.000 06030360 6C Bean, kidney, seed 0.600000 1.000 1.000 06030380 6C Bean, lima, seed 0.600000 1.000 1.000 06030390 6C Bean, mung, seed 0.600000 1.000 1.000 06030400 6C Bean, navy, seed 0.600000 1.000 1.000 06030410 6C Bean, pink, seed 0.600000 1.000 1.000 06030420 6C Bean, pinto, seed 0.600000 1.000 1.000 06030980 6C Chickpea, seed 0.600000 1.000 1.000 06030981 6C Chickpea, seed
- babyfood 0.600000 1.000 1.00 0 06030990 6C Chickpea, flour 0.600000 1.000 1.000 06031820 6C Guar, seed 0.600000 1.000 1.000 06031821 6C Guar, seed
- babyfood 0.600000 1.000 1.000 06032030 6C Lentil, seed 0.600000 1.000 1.000 08001480 8 Eggplant 1.500000 1.000 1.000 08002340 8 Okra 1.500000 1.000 1.000 08002700 8 Pepper, bell 1.500000 1.000 1.000 08002701 8 Pepper, bell
- babyfood 1.500000 1.000 1.000 08002710 8 Pepper, bell, dried 1.500000 1.000 1.000 08002711 8 Pepper, bell, dried
- babyfood 1.500000 1.000 1.000 08002720 8 Pepper, nonbell 1.500000 1.000 1.000 08002721 8 Pepper, nonbell
- babyfood 1.500000 1.000 1.000 08002730 8 Pepper, nonbell, dried 1.500000 1.000 1.000 08003740 8 Tomatillo 0.160000 1.000 1.000 08003750 8 Tomato 0.160000 1.000 1.000 08003751 8 Tomato
- babyfood 0.160000 1.000 1.000 08003760 8 Tomato, paste 0.160000 1.000 1.000 0 8003761 8 Tomato, paste
- babyfood 0.160000 1.000 1.000 08003770 8 Tomato, puree 0.160000 1.000 1.000 08003771 8 Tomato, puree
- babyfood 0.160000 1.000 1.000 08003780 8 Tomato, dried 0.160000 14.300 1.000 08003781 8 Tomato, dried
- babyfood 0.160000 14.300 1.000 08003790 8 Tomato, juice 0.160000 1.000 1.000 09010750 9A Cantaloupe 0.700000 1.0 00 1.000 09010800 9A Casaba 0.700000 1.000 1.000 09011870 9A Honeydew melon 0.700000 1.000 1.000 09013990 9A Watermelon 0.700000 1.000 1.000 09014000 9A Water melon, juice 0.700000 1.000 1.000 09020210 9B Balsam pear 0.700000 1.000 1.000 09020880 9B Chayote, fruit 0.700000 1.000 1.000 09021020 9B Chinese waxgourd 0 .700000 1.000 1.000 09021350 9B Cucumber 0.700000 1.000 1.000 09023080 9B Pumpkin 0.700000 1.000 1.000 09023090 9B Pumpkin, seed 0.700000 1.000 1.000 090235 60 9B Squash, summer 0.700000 1.000 1.000 09023561 9B Squash, summer
- babyfood 0.700000 1.000 1.000 09023570 9B Squash, winter 0.700000 1.000 1.000 09023571 9B Squash, winter
- babyfood 0.700000 1.000 1.000 10001080 10 Citrus, oil 60.000000 1.000 1.000 10001990 10 Lemon 0.260000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 17 of 21 10002000 10 Lemon, juice 0.260000 1.000 1 .000 10002001 10 Lemon, juice
- babyfood 0.260000 1.000 1.000 10002010 10 Lemon, peel 0.260000 1.000 1.000 10002060 10 Lime 0.260000 1.000 1.000 10002070 10 Lime, juic e 0.260000 1.000 1.000 10002071 10 Lime, juice
- babyfood 0.260000 1.000 1.000 11000070 11 Apple, fruit with peel 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11000080 11 A pple, peeled fruit 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11000081 11 Apple, peeled fruit
- babyfood 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11000090 11 Apple, dried 0.500000 8.000 1.000 PP#0F7

Full comment: PP#0F7696 11000091 11 Apple, dried
- babyfood 0.500000 8.000 1.000 PP#0F7

Full comment: PP#0F7696 11000100 11 Apple, juice 0.500000 1.300 1.000 PP#0F7

Full comment: PP#0F7696 11000101 11 Apple, juice
- babyfood 0.500000 1.300 1.000 PP#0F7

Full comment: PP#0F7696 11000110 11 Apple, sauce 0.500000 1.000 1.000 PP#0F7

Fu ll comment: PP#0F7696 11000111 11 Apple, sauce
- babyfood 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11001290 11 Crabapple 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 1100 2100 11 Loquat 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11002660 11 Pear 0.380000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11002661 11 Pear
- babyfood 0.380000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11002670 11 Pear, dried 0.380000 6.250 1.000 PP#0F7

Full comment: PP#0F7696 11002680 11 Pear, juice 0.38000 0 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11002681 11 Pear, juice
- babyfood 0.380000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 11003100 11 Quince 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696 12000120 12 Apricot 2.000000 1.000 1.000 12000121 12 Apricot
- babyfood 2.000000 1.000 1.000 12000130 12 Apricot, dried 2.000000 6.000 1.000 12000140 12 Apricot, juice 2.000000 1.000 1.000 12000141 12 Apricot, juice
- babyfood 2.000000 1.000 1.000 12000900 12 Cherry 2.000000 1.000 1.000 12000901 12 Cherry
- babyfood 2.000000 1.000 1.000 12000910 12 Cherry, juice 2.000000 1.500 1.000 12000911 12 Cherry, juice
- babyfood 2.000000 1.500 1.000 12002300 12 Nectarine 2.000000 1.000 1.000 12002600 12 Peach 2.000000 1.000 1.000 12002601 12 Peach
- babyfood 2.000000 1.000 1.000 12002610 12 Peach, dried 2.000000 7.000 1.000 12002611 12 Pe ach, dried
- babyfood 2.000000 7.000 1.000 12002620 12 Peach, juice 2.000000 1.000 1.000 12002621 12 Peach, juice
- babyfood 2.000000 1.000 1.000 12002850 12 Plum 2.000000 1.000 1.000 12002851 12 Plum
- babyfood 2.000000 1.000 1.000 12002860 12 Plum, prune, fresh 2.000000 1.000 1.000 12002861 12 Plum, prune, fresh
- babyfood 2.000000 1.000 1.000 120 02870 12 Plum, prune, dried 2.000000 5.000 1.000 12002871 12 Plum, prune, dried
- babyfood 2.000000 5.000 1.000 12002880 12 Plum, prune, juice 2.000000 1.400 1.000 12002881 12 Plum, prune, juice
- b abyfood 2.000000 1.400 1.000 13010550 13A Blackberry 10.000000 1.000 1.000 13010560 13A Blackberry, juice 10.000000 1.000 1.000 13010561 13A Blackberry, juice
- babyfood 10.000000 1.000 1.000 13010580 13A Boysenberry 10.000000 1.000 1.000 13011420 13A Dewberry 10.000000 1.000 1.000 13012080 13A Loganberry 10.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 18 of 21 13013200 13A Raspber ry 10.000000 1.000 1.000 13013201 13A Raspberry
- babyfood 10.000000 1.000 1.000 13013210 13A Raspberry, juice 10.000000 1.000 1.000 13013211 13A Raspberry, juice
- babyfood 10.0 00000 1.000 1.000 13020570 13B Blueberry 3.000000 1.000 1.000 13020571 13B Blueberry
- babyfood 3.000000 1.000 1.000 13021360 13B Currant 3.000000 1.000 1.000 13021370 13B Currant, dried 3.000000 1.000 1.000 13021490 13B Elderberry 3.000000 1.000 1.000 13021740 13B Gooseberry 3.000000 1.000 1.000 13021910 13B Huckleberry 3.000000 1.000 1.000 14000030 14 Almond 0.020000 1.000 1.000 14000031 14 Almond
- babyfood 0.020000 1.000 1.000 14000040 14 Almond, oil 0.020000 1.000 1.0 00 14000041 14 Almond, oil
- babyfood 0.020000 1.000 1.000 14002820 14 Pistachio 0.100000 1.000 1.000 19010280 19A Basil, fresh leaves 3.000000 1.000 1.000 19010281 19A Basil, fresh leaves
- babyfood 3.000000 1.000 1.000 19010290 19A Basil, dried leaves 15.000000 1.000 1.000 19010291 19A Basil, dried leaves
- babyfood 15.000000 1.000 1.000 19011030 19A Chive 3.000000 1.000 1.000 19011180 19A Coriander, leaves 3.000000 1.000 1.000 19011181 19A Coriander, leaves
- babyfood 3.000000 1.000 1.000 19011440 19A Dillweed 3.000000 1.000 1.000 19011840 19A Herbs, other 3.000000 1.000 1.000 19011841 19A Herbs, other
- babyfood 3.000000 1.000 1.000 19012020 19A Lemongrass 3.000000 1.000 1.000 19012200 19A Marjoram 3.000000 1.000 1.000 19012201 19A Marjoram
- babyfood 3.000000 1.000 1.000 19012490 19A Parsley, dried leaves 170.000000 1.000 1.000 19012491 19A Parsley, dried leaves
- babyfood 170.000000 1.000 1.000 19013340 19A Savory 3.000000 1.000 1.000 20003190 20 Rapeseed, oil 0.030000 1.000 1.000 20003191 20 Rapeseed, oil
- babyfood 0.030000 1.000 1.000 21000460 M Beef, meat byprod ucts 0.020000 1.000 1.000 21000461 M Beef, meat byproducts
- babyfood 0.020000 1.000 1.000 21000480 M Beef, kidney 0.020000 1.000 1.000 21000490 M Beef, liver 0.020000 1. 000 1.000 21000491 M Beef, liver
- babyfood 0.020000 1.000 1.000 23001700 M Goat, meat byproducts 0.020000 1.000 1.000 23001720 M Goat, kidney 0.020000 1.000 1.000 23001730 M Goat , liver 0.020000 1.000 1.000 26003400 M Sheep, meat byproducts 0.020000 1.000 1.000 26003420 M Sheep, kidney 0.020000 1.000 1.000 26003430 M Sheep, liver 0.020000 1.000 1.000 86010000 O Water, direct, all sources 0.024650 1.000 1.000 86020000 O Water, indirect, all sources 0.024650 1.000 1.000 95000200 O Avocado 1.200000 1.000 1.000 95000 740 O Canistel 1.200000 1.000 1.000 95001750 O Grape 0.810000 1.000 1.000 95001760 O Grape, juice 0.810000 1.200 1.000 95001761 O Grape, juice
- babyfood 0.810000 1.200 1.000 95001770 O Grape, leaves 0.810000 1.000 1.000 95001780 O Grape, raisin 3.000000 1.000 1.000 95001790 O Grape, wine and sherry 0.810000 1.000 1.000 95001950 O Kiwifruit 1.800000 1.000 1.000 95002090 O Longan 2.000000 1.000 1.000 95002110 O Lychee 2.000000 1.000 1.000 95002120 O Lychee, d ried 2.000000 1.850 1.000 95002150 O Mango 1.200000 1.000 1.000 95002151 O Mango
- babyfood 1.200000 1.000 1.000 95002160 O Mango, dried 1.200 000 1.000 1.000 95002170 O Mango, juice 1.200000 1.000 1.000 95002171 O Mango, juice
- babyfood 1.200000 1.000 1.000 95002450 O Papaya 1.200000 1.000 1.000 95002451 O Papaya - babyfood 1.200000 1.000 1.000 95002460 O Papaya, dried 1.200000 1.800 1.000 95002470 O Papaya, juice 1.200000 1.500 1.000 95003330 O Sapote, Mamey 1.200000 1.000 1.000 95003510 O Spanish lime 2.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 19 of 21 95003590 O Strawberry 5.000000 1.000 1.000 95003591 O Strawberry
- babyfood 5.000000 1.000 1.000 95003600 O Strawberry, juice 5.000000 1.000 1.000 95003601 O Strawberry, juice
- babyfood 5.000000 1.000 1.000 95003980 O Watercress 20.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 20 of 21 Attachment 3 Results of Acute DEEM
- FCI D Dietary Exposure Analy sis U.S. Environmental Protection Agency Ver. 2.02 DEEM - FCID ACUTE Analysis for CYPRODINIL (1994
- 98 data) Residue file: 288 202acuteEPArecommendations.R98 Adjustment factor #2 used. Analysis Date: 03
- 22
- 2012/07:11:33 Residue file dated: 03

- 22
- 2012/07:08:52/8 Daily totals for food and foodform consumption used. Run Comment: ""

=========================================== ==================================== Summary calculations (per capita): 95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---- ------ -------- ---------- -------- ---------- -------- U.S. Population: 0.095794 4.79 0.173478 8.67 0.327751 16.39 All infants: 0.102882 5.14 0.372488 18.62 0.943947 47.20 Childr en 1
- 2 yrs: 0.151445 7.57 0.288151 14.41 0.744868 37.24 Children 3
- 5 yrs: 0.131883 6.59 0.241040 12.05 0.536255 26.81 Children 6
- 12 yrs: 0.098193 4.91 0.16 7538 8.38 0.358174 17.91 Youth 13
- 19 yrs: 0.080270 4.01 0.160028 8.00 0.212343 10.62 Adults 20
- 49 yrs: 0.092162 4.61 0.172228 8.61 0.309780 15.49 Adults 50+ yrs: 0.085400 4.27 0.155374 7.77 0.264973 13.25 Females 13
- 49 yrs: 0.099465 4.97 0.174098 8.70 0.309890 15.49Cyprodinil (PC C ode 288202 ) Dietary Exposure and Risk Assessment DP # 3 90233 & 39 8362 :



### Page 21 of 21 Attachment 4 Results of Chronic DEEM
- FCI D Dietary Exposure Analy sis U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for CYPRODINIL (1994
- 98 data) Residue file name: C: \ Documents and Settings \ tmorton \ My Documents \ MyFiles \ D EEM Files \ 288202 Cyprodinil \ Leafy Petioles 1E7869 and Misc 1E7854 \ 288202chronicEPArecommendations.R98 Adjustment factor #2 used. Analysis Date 03
- 22
- 2012/07:13:12 Residue file dated: 03

- 22
- 2012/07:09 :53/8 Reference dose (RfD, Chronic) = .027 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------- ----------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgr oup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.007421 27.5% U.S. Population (spring season) 0.007725 28.6% U.S. Population (summer season) 0.007667 28.4% U.S. Population (autumn season) 0.007106 26.3% U.S. Population (winter season) 0.007194 26.6% No rtheast region 0.007971 29.5% Midwest region 0.007167 26.5% Southern region 0.006476 24.0% Western region 0.008696 32.2% Hispanics 0.007440 27.6% Non - hispanic whites 0.007328 27.1% Non - hispanic blacks 0.006939 2 5.7% Non - hisp/non

- white/non

- black 0.010253 38.0% All infants (< 1 year) 0.014099 52.2% Nursing infants 0.007361 27.3% Non - nursing infants 0.016657 61.7% Children 1
- 6 yrs 0.016210 60.0% Children 7
- 12 yrs 0.008060 29.9% Females 13
- 19 (not preg or nursing) 0.005111 18.9% Females 20+ (not preg or nursing) 0.006767 25.1% Females 13
- 50 yrs 0.006317 23.4% Females 13+ (preg/not nursing) 0.006768 25.1% Females 13+ (nursing) 0.007128 26.4% Males 13
- 19 yrs 0.005276 19.5% Males 20+ yrs 0.005869 21.7% Seniors 55+ 0.007358 27.3% Children 1
- 2 yrs 0.020269 75.1% Children 3
- 5 yrs 0.015148 56.1% Children 6
- 12 yrs 0.008552 31.7% Youth 13
- 19 yrs 0.005195 19.2% Adults 20
- 49 yrs 0.005818 21.5% Adults 50+ yrs 0.007260 26.9% Females 13
- 49 yrs 0.006066 22.5%

-------------------------------------------------------------------------------