**Fluazifop -** **p -**  **butyl Registration Review Focus Meeting Held.**  On July 31 , 2014 the OPP

registration review team met with representatives from USDA and Syngenta to discuss use and usage , and previously submitted studies . Fluazifop - p - butyl is a selective, post- emergent herbicide registered for the control of perennial and annual grass weeds. Currently, it is registered for use on a number of food and feed including soybeans, cotton and carrots. It is also registered for u se on lawns/turf. The registration review docket initiating a 60 - day public comment period on the Fluazifop - p - butyl is scheduled to open December 2014, and will include a Preliminary Work Plan and supporting documents. Participants **BEAD** : Sepehr Haddad , Bill Phillips, Steve Smearman **EFED** : Nick Federoff, Edmund Wong, Jean Holmes, Brian Anderson **HED** : Michael Metzger, William Donovan, Stephen Dapson, Alexandra LaMay **PRD RMIB2**  : Matthew Manupella, Cathryn B ritton, Kevin Costello **RD** : Kathryn Montague , Shanta Adeeb **USDA**: Jill Schroeder, Sheryl Kunickis **Syngenta** : Tamara Murphy, Adora Clark, Amber Goetz Dialing in : J erry Wells, Paul Moore, JiSu Bang, Ted Valenti, Russell Underwood Discussion Summary 1. The team discussed a previously submitted soil crosswalk report (MRID 49188707), “Evaluating the comparability of Foreign Soils used in Environmental Fate Studies for Fluazifop -P- butyl with the use Area Soils in the United States. ” Syngenta will be submitt ing a soil crosswalk report for five additional soil types not covered in MRID 49188707. Syngenta presented data showing soils collected from the European sites (MRIDs 46190602, 87493, 16246545) used in laboratory environmental fate and behavior studies fo r fluazifop - P - butyl and fluazifop - butyl, could be found in areas of geographical, climatic, and geo - physicochemical conditions similar to soils in the label uses for fluazifop - P - butyl in the United States. 2. EPA expressed a need for analytical chemistry me thods capable of identifying and quantifying each separate enantiomer and fluazifop - butyl and fluazifop - acid in soil, water, and tissue. Syngenta will be submitting a chiral soil analytical method final report upon completion in early 2015. Fluazifop - butyl and fluazifop - P - butyl have similar toxicological profiles. Syngenta proposed that no chiral methods should be required for water and fish tissues based on similar toxicological findings between the R and racemic mixture and no significant epimerization of R to S enantiomeric forms have been found in soil or plants. Syngenta will be submitting a justification to waive the need for chiral analytical methods for water and fish tissues. 3. Metabolite 5 - trifluoromethyl- 2 - pyridone (TFP) was identified as a residue of concern in plants for risk assessment purposes by the 2004 Metabolism Assessment Review Committee (MARC), which was unable to conclude that TFP is significantly less toxic than the parent based on structural considerations. Syngenta will be submitting pharmacokinetic and toxic ological data, showing TFP was found to be acutely not toxic, not toxic after repeated administration for 28 days, and was not a fetal developmental toxicant in rats. Syngenta will submit supporting documents for the TFP metabolite.