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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549





FORM 10-K/A

(Amendment
No. 1)





(Mark One)



|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934.
|- | -------------------------------------------------------------------------------------



| | For the fiscal year ended December 31, 2007
| | -------------------------------------------

or



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934.
|- | -----------------------------------------------------------------------------------------



| | For the transition period from  to
| | ----------------------------------

Commission file number: 001-15989





ENDO PHARMACEUTICALS HOLDINGS
INC.

(Exact name of registrant as specified in its charter)



|                                                               |  |                                        
|-------------------------------------------------------------- |  | ---------------------------------------
|Delaware                                                       |  | 13-4022871                             
|(State or other jurisdiction of incorporation or organization) |  | (I.R.S. Employer Identification Number)
|                                                               | 
|100 Endo Boulevard Chadds Ford, Pennsylvania                   |  | 19317                                  
|(Address of Principal Executive Offices)                       |  | (Zip Code)                             

(Registrants Telephone Number, Including Area Code): (610) 558-9800

Securities registered pursuant to Section 12(b) of the Act: N/A

Securities registered pursuant to Section 12(g) of the Act:



|                                |  |                                          
|------------------------------- |  | -----------------------------------------
|Title of Each Class             |  | Name of Each Exchange on Which Registered
|Common Stock of $0.01 par value |  | NASDAQ                                   

Annual Report for the Year Ended December 31, 2007





Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes x No  ̈

Indicate by check mark if the registrant is not required
to file reports pursuant to Section 13 or 15(d) of the Act.    YES   ̈    NO  x

Indicate by check whether the registrant: (1) has filed all reports required to be filed by Sections 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  x    No   ̈

Indicate by check if disclosure
of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of
this Form 10-K or any amendment to this Form 10-K.    x

Indicate by check mark
whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of accelerated filer and large accelerated filer in Rule 12b-2 of the Exchange Act. (Check one):

Large accelerated filer  x        Accelerated filer   ̈        Non-accelerated filer   ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). YES  ̈ NO x

State the aggregate market value of the voting and non-voting common equity held by non-affiliates computed by reference to the price at which the common
equity was last sold, or the average bid and asked price of such common equity, as of the last business day of the registrants most recently completed second fiscal quarter (June 30, 2007): $4,541,775,544 based on the last reported sale price
on the NASDAQ on June 29, 2007.

Indicate the number of shares outstanding of each of the registrants classes of common stock,
as of February 15, 2008: 134,144,993









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ENDO PHARMACEUTICALS HOLDINGS INC.

INDEX TO FORM 10-K/A

FOR THE YEAR ENDED DECEMBER 31, 2007



|                                                                                                                    |  |   
|------------------------------------------------------------------------------------------------------------------- |  | --
|Explanatory Note                                                                                                    |  | 1 
|Cautionary Note Regarding Forward-Looking Statements                                                                |  | 1 
|                                                                                                                    | 
|PART I                                                                                                              |  | 3 
|Item 1A Risk Factors                                                                                                |  | 3 
|                                                                                                                    | 
|PART II                                                                                                             |  | 25
|Item 5 Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities |  | 25
|                                                                                                                    | 
|PART III                                                                                                            |  | 28
|Item 10 Directors, Executive Officers and Corporate Governance                                                      |  | 28
|Item 11 Executive Compensation                                                                                      |  | 35
|Item 12 Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters              |  | 63
|Item 13 Certain Relationships and Related Transactions, and Director Independence                                   |  | 67
|Item 14 Principal Accountant Fees and Services                                                                      |  | 72
|                                                                                                                    | 
|PART IV                                                                                                             |  | 73
|Item 15 Exhibits, Financial Statement Schedules                                                                     |  | 73
|Signatures                                                                                                          |  | 74
|Exhibit Index                                                                                                       |  |   
|Certifications                                                                                                      |  |   



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EXPLANATORY NOTE

Endo Pharmaceuticals Holdings Inc. is filing this Amendment No. 1 on Form 10-K/A
to amend its Form 10-K for the year ended December 31, 2007, filed with the Securities and Exchange Commission (the SEC) on February 26, 2008 (the Original 10-K). The Company is hereby amending the Original
10-K for the purpose of providing the information required by Part III of the Original 10-K in its entirety (which includes an updated list of the Companys executive officers that was initially included in Part I, Item 4A of the
Original 10-K). The information required by Part III of Form 10-K is no longer being incorporated by reference from the Registrants Proxy Statement. Accordingly, reference to the Registrants Proxy Statement on the cover page in
the Original 10-K has been deleted. Part I Item 1A of the Original 10-K is also being amended for the purpose of providing an update to our risk factors and to correct certain typographical errors in the Original 10-K. Part II is being
amended solely to furnish our stock performance graph.

In addition, pursuant to the rules of the Securities and Exchange Commission, the
Company is including with this Amendment certain currently dated certifications. These certifications are included as Exhibits 31.3, 31.4 , 32.1 and 32.2. Item 15(b) of Part IV of the Form 10-K is also restated to reflect that
these certifications are being included as exhibits to this Form 10-K/A.

Except for the amendments and updates described above, this
Amendment No. 1 on Form 10-K/A does not modify or update in any way the Original 10-K. Unless expressly stated, this Amendment No. 1 does not reflect events occurring after the filing of the Original 10-K, nor does it modify or update
in any way the disclosures contained in the Original 10-K. Accordingly, this Amendment should be read in conjunction with our Original 10-K and our other filings made with the SEC subsequent to the filing of the Original 10-K.

Throughout this report, references to the Company, we, our, or us refer to Endo Pharmaceuticals Holdings
Inc. and its consolidated subsidiaries, taken as a whole, unless the context otherwise indicates.

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

Statements contained or incorporated by reference in
this Amendment No. 1 on Form 10-K/A contain information that includes or is based on forward-looking statements within the meaning of Section 27A of the Securities Act and Section 21E of the Exchange Act. These statements,
including estimates of future net sales, future expenses, future net income and future earnings per share, contained in the section titled Managements Discussion and Analysis of Financial Condition and Results of Operations, in our
Annual Report on Form 10-K for the year ended December 31, 2007, filed with the Securities and Exchange Commission on February 26, 2008, are subject to risks and uncertainties. Forward-looking statements include the information concerning
our possible or assumed results of operations. Also, statements including words such as believes, expects, anticipates, intends, estimates, plan, will,
may or similar expressions are forward-looking statements. We have based these forward-looking statements on our current expectations and projections about the growth of our business, our financial performance and the development of our
industry. Because these statements reflect our current views concerning future events, these forward-looking statements involve risks and uncertainties. Investors should note that many factors, as more fully described under the caption Risk
Factors in Item 1A of this Amendment No. 1 on Form 10-K/A for the year ended December 31, 2007, and as otherwise enumerated herein or therein, could affect our future financial results and could cause our actual results to
differ materially from those expressed in forward-looking statements contained in this Amendment No. 1 on Form 10-K/A. Important factors that could cause our actual results to differ materially from the expectations reflected in the
forward-looking statements in this Amendment No. 1 on Form 10-K/A include



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those factors described herein under the caption Risk Factors and in documents incorporated herein by reference, including, among others:



| |  |  | our ability to successfully develop, commercialize and market new products;
| | - |  | ---------------------------------------------------------------------------

| |  |  | timing and results of pre-clinical or clinical trials on new products;
| | - |  | ----------------------------------------------------------------------

| |  |  | our ability to obtain regulatory approval of any of our pipeline products;
| | - |  | --------------------------------------------------------------------------

| |  |  | competition for the business of our branded and generic products, and in connection with our acquisition of rights to intellectual property assets;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------

| |  |  | market acceptance of our future products;
| | - |  | -----------------------------------------

| |  |  | government regulation of the pharmaceutical industry;
| | - |  | -----------------------------------------------------

| |  |  | our dependence on a small number of products;
| | - |  | ---------------------------------------------

| |  |  | our dependence on outside manufacturers for the manufacture of our products;
| | - |  | ----------------------------------------------------------------------------

| |  |  | our dependence on third parties to supply raw materials and to provide services for certain core aspects of our business;
| | - |  | -------------------------------------------------------------------------------------------------------------------------

| |  |  | new regulatory action or lawsuits relating to our use of narcotics in most of our core products;
| | - |  | ------------------------------------------------------------------------------------------------

| |  |  | our exposure to product liability claims and product recalls and the possibility that we may not be able to adequately insure ourselves;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------

| |  |  | our ability to protect our proprietary technology;
| | - |  | --------------------------------------------------

| |  |  | the successful efforts of manufacturers of branded pharmaceuticals to use litigation and legislative and regulatory efforts to limit the use of generics and certain
other products;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| |  |  | our ability to successfully implement our acquisition and in-licensing strategy;
| | - |  | --------------------------------------------------------------------------------

| |  |  | regulatory or other limits on the availability of controlled substances that constitute the active ingredients of some of our products and products in development;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------

| |  |  | the availability of third-party reimbursement for our products;
| | - |  | ---------------------------------------------------------------

| |  |  | the outcome of any pending or future litigation or claims by the government;
| | - |  | ----------------------------------------------------------------------------

| |  |  | our dependence on sales to a limited number of large pharmacy chains and wholesale drug distributors for a large portion of our total net sales;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------

| |  |  | significant litigation expenses to defend or assert patent infringement claims;
| | - |  | -------------------------------------------------------------------------------

| |  |  | any interruption or failure by our suppliers, distributors and collaboration partners to meet their obligations pursuant to various agreements with us;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------

| |  |  | a determination by a regulatory agency that we are engaging in inappropriate sales or marketing activities, including promoting the off-label use of our
products;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------

| |  |  | existing suppliers become unavailable or lose their regulatory status as an approved source, causing an inability to obtain required components, raw materials or
products on a timely basis or at commercially reasonable prices;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| |  |  | the loss of branded product exclusivity periods and related intellectual property; and
| | - |  | --------------------------------------------------------------------------------------

| |  |  | our exposure to securities that are subject to market risk.
| | - |  | -----------------------------------------------------------

We do not undertake any obligation to update our forward-looking statements after the date of this Amendment No. 1 on Form 10-K/A for any reason, even if new information becomes available or other events occur in
the future. You are advised, however, to consult any further disclosures we make on related subjects in reports we file with the SEC.



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PART I



|Item 1A. | Risk Factors
|-------- | ------------

Risks
Related to Our Business

We face intense competition, in particular from companies that develop rival products to our branded products and from
companies with which we compete to acquire rights to intellectual property assets.

The pharmaceutical industry is intensely
competitive, and we face competition across the full range of our activities. If we fail to compete successfully in any of these areas, our business, results of operations and financial condition could be adversely affected. Our competitors include
many of the major brand name and generic manufacturers of pharmaceuticals, especially those doing business in the United States. In the market for branded pharmaceutical products, our competitors, including Abbott Laboratories, Alpharma Inc.,
Johnson & Johnson, King Pharmaceuticals Inc., Cephalon, Inc., Pfizer, Inc. and The Purdue Frederick Company, vary depending on product category, dosage strength and drug-delivery systems. In addition to product safety, development and
efficacy, other competitive factors in the branded pharmaceutical market include product quality and price, reputation, service and access to scientific and technical information. It is possible that developments by our competitors will make our
products or technologies uncompetitive or obsolete. Because we are smaller than many of our national competitors in the branded pharmaceutical products sector, we may lack the financial and other resources needed to maintain our profit margins and
market share in this sector.

The intensely competitive environment of the branded products business requires an ongoing, extensive search
for medical and technological innovations and the ability to market products effectively, including the ability to communicate the effectiveness, safety and value of branded products for their intended uses to healthcare professionals in private
practice, group practices and managed care organizations. There can be no assurance that we will be able to successfully develop medical or technological innovations or that we will be able to effectively market existing products or new products we
develop.

Our branded products face competition from generic versions. Generic
versions are generally significantly cheaper than the branded version, and, where available, may be required or encouraged in preference to the branded version under third party reimbursement programs, or substituted by pharmacies for branded
versions by law. The entrance of generic competition to our branded products generally reduces our market share and adversely affects our profitability and cash flows. Generic competition with our branded products, including Percocet®, has had and will continue to have a material adverse effect on the net sales and profitability of our branded products.

Additionally, we compete to acquire the intellectual property assets that we require to continue to develop and broaden our product range. In addition to
our in-house research and development efforts, we seek to acquire rights to new intellectual property through corporate acquisitions, asset acquisitions, licensing and joint venture arrangements. Competitors with greater resources may acquire assets
that we seek, and even where we are successful, competition may increase the acquisition price of such assets or prevent us from capitalizing on such acquisitions or licensing opportunities. If we fail to compete successfully, our growth may be
limited.

If generic manufacturers use litigation and regulatory means to obtain approval for generic versions of our branded drugs, our sales may
suffer.

Under the Federal Food, Drug and Cosmetics Act, or the FDCA Act, the FDA can approve an abbreviated new drug application, or
ANDA, for a generic version of a branded drug and what is referred to as a Section 505(b)(2) new drug application, or NDA, for a branded variation of an existing branded drug, without undertaking the clinical testing necessary to obtain
approval to market a new drug. We refer to this process as the ANDA process. In place of such clinical studies, an ANDA applicant usually needs only to submit data



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demonstrating that its product has the same active ingredient(s) and is bioequivalent to the branded product, in addition to any data necessary to establish
that any difference in strength, dosage form, inactive ingredients, or delivery mechanism does not result in different safety or efficacy profiles, as compared to the reference drug.

The FDCA Act requires an applicant for a drug that relies, at least in part, on the patent of one of our branded drugs to notify us of their application
and potential infringement of our patent rights. Upon receipt of this notice we have 45 days to bring a patent infringement suit in federal district court against the company seeking approval of a product covered by one of our patents. The
discovery, trial and appeals process in such suits can take several years. If such a suit is commenced, the FDCA Act provides a 30-month stay on the FDAs approval of the competitors application. Such litigation is often time-consuming
and quite costly and may result in generic competition if such patent(s) are not upheld or if the generic competitor is found not to infringe such patent(s). If the litigation is resolved in favor of the applicant or the challenged patent expires
during the 30-month stay period, the stay is lifted and the FDA may thereafter approve the application based on the standards for approval of ANDAs and Section 505(b)(2) NDAs.

In December 2006, the Division of Bioequivalence, Office of Generic Drugs, Center for Drug
Evaluation and Research, or OGD, issued draft guidance making recommendations regarding establishing bioequivalence with our patent-protected product, Lidoderm® (lidocaine topical patch
5%), pursuant to which a party could seek ANDA approval of a generic version of that product. In that draft guidance, OGD has recommended a bioequivalence study characterizing the pharmacokinetic profile of lidocaine as well as a skin
irritation/sensitization study of any lidocaine-containing patch formulation. This recommendation deviates from our understanding of the applicable regulations and of OGDs past practices, which, for a topically acting product such as
Lidoderm®, would require demonstration of bioequivalence through a comparative clinical equivalency study rather than through a pharmacokinetic study.

On December 19, 2006, we submitted a Citizen Petition to the FDA requesting that the FDA
apply existing bioequivalence regulations to any ANDA seeking regulatory approval of a generic drug product that references Lidoderm®. We submitted an amendment to that filing in August
2007 in order to provide additional data. Our Citizen Petition emphasizes that the FDAs recommendation deviates from applicable regulations and OGDs past practices, both of which contemplate demonstration of bioequivalence for a
topically acting product like Lidoderm® through a comparative clinical efficacy study. We believe blood levels of the active ingredient, lidocaine, cannot properly be used as the key
measure in proving bioequivalence. To appropriately assess the efficacy and safety of any generic version of Lidoderm®, we believe that it is critical that the FDA require any ANDA
applicant relying on Lidoderm® as its Reference Listed Drug satisfy the regulations by conducting comparative clinical studies demonstrating (1) bioequivalence between the generic
version and Lidoderm®, and (2) that the generic version produces the same local analgesic effect as Lidoderm® without
producing a complete sensory block, in order to assure that the generic product has the same labeling, efficacy and safety profile as Lidoderm®. The FDA has not acted on this Petition, and
it is unclear whether or not the FDA will agree with our position. In addition to this Petition, on September 28, 2007, we filed comments with FDA regarding the draft guidance; those comments reiterated our position as set forth in the
Petition, referencing the Petition and supporting data. The draft guidance remains available and has not been updated or revised since being issued.

On December 14, 2007, we received a notice from IMPAX advising of the FDAs apparent
acceptance for substantive review, as of November 23, 2007, of IMPAXs amended ANDA for a generic version of Opana® ER. IMPAX stated in its letter that the FDA requested
IMPAX to provide notification to us and Penwest Pharmaceuticals Co., or Penwest, our development partner for Opana® ER, of any Paragraph IV certifications submitted with its ANDA, as
required under Section 355(j) of the FDCA Act. Accordingly, IMPAXs letter included notification that it had filed Paragraph IV certifications with respect to Penwests U.S. Patent Nos. 7,276,250, 5,958,456 and 5,662,933, which
cover the formulation of Opana® ER. These patents are listed in the FDAs Orange Book and expire in 2022, 2013 and 2013, respectively. Our Opana® ER product has new dosage form exclusivity that prevents final approval of any ANDA by the FDA until the exclusivity expires on June 22, 2009. In addition, because IMPAXs application referred
to patents owned by Penwest and



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contained a Paragraph IV certification under Section 355(j) of the FDCA Act, we believe IMPAXs notice triggered the 45-day period under the FDCA
Act in which we and Penwest could file a patent infringement action and trigger the automatic 30-month stay of approval. Subsequently, on January 25, 2008, we and our partner, Penwest, filed a lawsuit against IMPAX in the U.S. District Court
for the District of Delaware in connection with IMPAXs ANDA. The lawsuit alleges infringement of certain Orange Book-listed U.S. patents that cover the Opana® ER
formulation. Additionally, the lawsuit previously filed by us and Penwest on November 15, 2007 against IMPAX remains pending. We cannot predict the outcome of this litigation.

In February 2008, we along with our partner Penwest, received a notice from Actavis South Atlantic
LLC, or Actavis, advising of the filing by Actavis of an ANDA containing a Paragraph IV certification under 21 U.S.C. Section 355(j) for a generic version of Opana® ER (oxymorphone
hydrochloride extended-release tablets CII). The Actavis Paragraph IV certification notice refers to Penwests U.S. Patent Nos. 5,128,143, 5,662,933, 5,958,456 and 7,276,250, which cover the formulation of Opana® ER. These patents are listed in the FDAs Orange Book and expire in 2008, 2013, 2013 and 2023, respectively. In addition to these patents, Opana® ER
has a new dosage form (NDA) exclusivity that prevents final approval of any ANDA by the FDA until the exclusivity expires on June 22, 2009. Subsequently, on March 28, 2008, we and Penwest filed a lawsuit against Actavis in the U.S.
District Court for the District of New Jersey in connection with Actaviss ANDA. The lawsuit alleges infringement of certain Orange Book-listed U.S. patents that cover the Opana® ER
formulation. We cannot predict the outcome of this litigation. We note that we and Penwest intend to pursue all available legal and regulatory avenues in defense of Opana® ER,
including enforcement of our intellectual property rights and approved labeling.

The filing of the aforementioned applications, or any other ANDA or Section 505(b)(2) NDA in respect to any of our branded drugs, particularly Lidoderm®, could have an adverse
impact on our stock price. Moreover, if the patents covering our branded drugs, including Lidoderm® or Opana® ER were not upheld
in litigation or if a generic competitor is found not to infringe these patents, the resulting generic competition would have a material adverse effect on our net sales, gross profit, operating income, net income and cash flows.



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Patent litigation which is often time-consuming and expensive could have a material adverse effect on our business,
results of operations and financial condition.

The expense of patent litigation, whether or not we are successful, could have an
adverse effect on our business, results of operations and financial condition. Regardless of FDA approval, should we commence a lawsuit against a third party for patent infringement or should there be a lawsuit commenced against us with respect to
any alleged patent infringement by us, in either case, whether because of the filing of an ANDA or otherwise, the uncertainties inherent in patent litigation make the outcome of such litigation difficult to predict. The cost of such litigation as
well as the ultimate outcome of such litigation, if commenced, could have a material adverse effect on our business, results of operations and financial condition.

Most of our net sales come from a small number of products.

The following table displays our net sales by product category
and as a percentage of total net sales for the years ended December 31, 2007, 2006 and 2005 (dollars in thousands):



|                                           |  |                         |           |  |      |   |  |      |         |  |     |   |  |   |         |  |     |  
|------------------------------------------ |  | ----------------------- | --------- |  | ---- | - |  | ---- | ------- |  | --- | - |  | - | ------- |  | --- | -
|                                           |  | Year Ended December 31, |          
|                                           |  | 2007                    |           |  | 2006 |   |  | 2005 |        
|Lidoderm®                                  |  | $                       | 705,587   |  | 65   | % |  | $    | 566,785 |  | 62  | % |  | $ | 419,418 |  | 51  | %
|Percocet®                                  |  |                         | 121,742   |  | 11   |   |  |      | 102,707 |  | 11  |   |  |   | 110,700 |  | 13  |  
|Opana® ER and Opana®                       |  |                         | 107,143   |  | 10   |   |  |      | 6,845   |  | 1   |   |  |   |        |  |    |  
|Frova®                                     |  |                         | 52,437    |  | 5    |   |  |      | 40,564  |  | 5   |   |  |   | 38,096  |  | 5   |  
|Other brands                               |  |                         | 11,065    |  | 1    |   |  |      | 14,027  |  | 1   |   |  |   | 15,029  |  | 2   |  
|                                           |  |                         |           |  |      |   |  |      |         |  |     |   |  |   |         |  |     |  
|Total brands                               |  |                         | 997,974   |  | 92   |   |  |      | 730,928 |  | 80  |   |  |   | 583,243 |  | 71  |  
|Generic oxycodone extended-release tablets |  |                         |          |  |     |   |  |      | 57,075  |  | 6   |   |  |   | 113,969 |  | 14  |  
|Other generics                             |  |                         | 87,634    |  | 8    |   |  |      | 121,656 |  | 14  |   |  |   | 122,952 |  | 15  |  
|                                           |  |                         |           |  |      |   |  |      |         |  |     |   |  |   |         |  |     |  
|Total generics                             |  |                         | 87,634    |  | 8    |   |  |      | 178,731 |  | 20  |   |  |   | 236,921 |  | 29  |  
|                                           |  |                         |           |  |      |   |  |      |         |  |     |   |  |   |         |  |     |  
|Total net sales                            |  | $                       | 1,085,608 |  | 100  | % |  | $    | 909,659 |  | 100 | % |  | $ | 820,164 |  | 100 | %
|                                           |  |                         |           |  |      |   |  |      |         |  |     |   |  |   |         |  |     |  

The FDA granted Lidoderm® orphan drug status for the treatment of the pain associated with post-herpetic neuralgia, which meant, generally, that no other lidocaine-containing product could have been approved for this
indication prior to March 19, 2006. While the orphan drug exclusivity period for Lidoderm® has expired, that product is covered by Orange Book-listed patents through 2015, and any
party seeking approval for a generic version of Lidoderm® in spite of our patent rights would be obligated to notify us of the filing of its application with the FDA.

If we are unable to continue to market any of our products, if any of them were to lose market share, for example, as the result of the entry of new
competitors, particularly from generic versions of branded drugs, or if the prices of any of these products were to decline significantly, our net sales, profitability and cash flows would be materially adversely affected.

Our ability to protect our proprietary technology, which is vital to our business, is uncertain.

Our success, competitive position and amount of future income will depend in part on our ability to obtain patent protection relating to the
technologies, processes and products we are currently developing and that we may develop in the future. Our policy is to seek patent protection and enforce the intellectual property rights we own and license. We cannot assure you that patent
applications we submit and have submitted will result in patents being issued. If an advance is made that qualifies as a joint invention, the joint inventor or his or her



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employer may have rights in the invention. We cannot assure you that a third party will not infringe upon, design around or develop uses not covered by any
patent issued or licensed to us or that these patents will otherwise be commercially viable. In this regard, the patent position of pharmaceutical compounds and compositions is particularly uncertain. Even issued patents may later be modified or
revoked by the U.S. Patent and Trademark Office, or PTO, or in legal proceedings. Moreover, we believe that obtaining foreign patents may be more difficult than obtaining domestic patents because of differences in patent laws and, accordingly, our
patent position may be stronger in the United States than abroad. Foreign patents may be more difficult to protect and/or the remedies available may be less extensive than in the United States. Various countries limit the subject matter that can be
patented and limit the ability of a patent owner to enforce patents in the medical field. This may limit our ability to obtain or utilize those patents internationally. Patent applications in the United States are maintained in secrecy until at
least 18 months after the filing of the application with the PTO and, since publication of discoveries in the scientific or patent literature tends to lag behind actual discoveries, we cannot be certain that we were the first creator of the
inventions covered by pending patent applications or the first to file patent applications on those inventions. Several drug companies and research and academic institutions have developed technologies, filed patent applications or received patents
for technologies that may be related to our business. Others may file patent applications and may receive patents that may conflict with patents or patent applications we have obtained or licensed for our use, either by claiming the same methods or
compounds or by claiming methods or compounds that could dominate those owned by or licensed to us. We cannot assure you that any of our pending patent applications will be allowed, or, if allowed, whether the scope of the claims allowed will be
sufficient to protect our products. Litigation to establish the validity of patents, to defend against patent infringement claims of others and to assert patent infringement claims against others can be expensive and time-consuming even if the
outcome is favorable to us. If the outcome is unfavorable to us, this could have a material adverse effect on our business. We have taken and may, in the future, take steps to enhance our patent protection, but we cannot assure you that these steps
will be successful or that, if unsuccessful, our patent protection will be adequate.

We also rely upon trade secrets, know-how, continuing
technological innovations and licensing opportunities to develop and maintain our competitive position. We attempt to protect our proprietary technology in large part by confidentiality agreements with our employees, consultants and other
contractors. We cannot assure you, however, that these agreements will not be breached, that we would have adequate remedies for any breach or that competitors will not know of, or independently discover, our trade secrets. We cannot assure you that
others will not independently develop substantially equivalent proprietary information or be issued patents that may prevent the sale of our products or know-how or require licensing and the payment of significant fees or royalties by us in order to
produce our products. Moreover, we cannot assure you that our technology does not infringe upon any valid claims of patents that other parties own.

In the future, if we were found to be infringing on a patent, we might have to seek a license to use the patented technology. We cannot assure you that, if required, we would be able to obtain such a license on terms acceptable to us, if at
all. If a third party brought a legal action against us or our licensors, we could incur substantial costs in defending ourselves, and we cannot assure you that such an action would be resolved in our favor. If such a dispute were to be resolved
against us, we could be subject to significant damages, and the testing, manufacture or sale of one or more of our technologies or proposed products, if developed, could be enjoined.

We cannot assure you as to the degree of protection any patents will afford, whether the PTO will issue patents or whether we will be able to avoid
violating or infringing upon patents issued to others or that others will not manufacture and distribute our patented products upon expiration of the applicable patents. Despite the use of confidentiality agreements and non-compete agreements, which
themselves may be of limited effectiveness, it may be difficult for us to protect our trade secrets.



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We may incur significant liability if it is determined that we are promoting the off-label use of drugs.

Companies may not promote drugs for off-label uses  that is, uses that are not described in the
products labeling and that differ from those approved by the FDA. Physicians may prescribe drug products for off-label uses, and such off-label uses are common across some medical specialties. Although the FDA and other regulatory agencies do
not regulate a physicians choice of treatments, the Federal Food, Drug and Cosmetics Act and FDA regulations restrict communications on the subject of off-label uses of drug products by pharmaceutical companies. The Office of Inspector General
of the Department of Health and Human Services (OIG) and FDA both actively enforce laws and regulations prohibiting promotion of off-label uses and the promotion of products for which marketing clearance has not been obtained. A company that is
found to have improperly promoted off-label uses may be subject to significant liability, including civil and administrative remedies as well as criminal sanctions.

Notwithstanding the regulatory restrictions on off-label promotion, the OIG and the FDA allow companies to engage in truthful, non-misleading, and non-promotional speech concerning their products. Although we believe
that all of our communications regarding all of our products are in compliance with the relevant legal requirements, the OIG or the FDA may disagree, and we may be subject to significant liability, including civil and administrative remedies, as
well as criminal sanctions. In addition, managements attention could be diverted from our business operations and our reputation could be damaged.

In January 2007, we received a subpoena issued by the OIG. The subpoena requests documents
relating to Lidoderm® (lidocaine patch 5%) that are focused primarily on the sale, marketing and promotion of Lidoderm®. We are
cooperating with the government to provide the requested documents. At this time, we cannot predict or determine the outcome of the above matter or reasonably estimate the amount or range of amounts of fines or penalties that might result from an
adverse outcome. However, should the government choose to initiate action against us, we could face substantial penalties, which could have a material adverse effect on our business, financial condition and results of operations.



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We may incur liability if our continuing medical or health education programs and/or product promotions are
determined, or are perceived, to be inconsistent with regulatory guidelines.

The FDA provides guidelines with respect to appropriate
promotion and continuing medical and health education activities. Although we endeavor to follow these guidelines, the FDA or the OIG may disagree, and we may be subject to significant liability, including civil and administrative remedies as well
as criminal sanctions. Should the government choose to initiate action against us, we could face substantial penalties, which could have a material adverse effect on our business, financial condition and results of operations. In addition,
managements attention could be diverted and our reputation could be damaged.

We are subject to various regulations pertaining to the marketing of
our products.

We are subject to various federal and state laws pertaining to healthcare fraud and abuse, including prohibitions on the
offer of payment or acceptance of kickbacks or other remuneration for the purchase of our products. Specifically, these anti-kickback laws make it illegal for a prescription drug manufacturer to solicit, offer, or pay any remuneration in exchange
for purchasing, leasing or ordering any service or items including the purchase or prescription of a particular drug for which payment may be made under a federal health care program. Because of the sweeping language of the federal anti-kickback
statute, many potentially beneficial business arrangements would be prohibited if the statute were strictly applied. To avoid this outcome, the U.S. Department of Health and Human Services has published regulations  known as safe
harbors  that identify exceptions or exemptions to the statutes prohibitions. Arrangements that do not fit within the safe harbors are not automatically deemed to be illegal, but must be evaluated on a case-by-case basis for
compliance with the statute. We seek to comply with anti-kickback statutes and to fit within one of the defined safe harbors; we are unaware of any violations of these laws. However, due to the breadth of the statutory provisions and the
absence of uniform guidance in the form of regulations or court decisions, there can be no assurance that our practices will not be challenged under anti-kickback or similar laws. Violations of such restrictions may be punishable by civil and/or
criminal sanctions, including fines and civil monetary penalties, as well as the possibility of exclusion from U.S. federal healthcare programs (including Medicaid and Medicare). Any such violations could have a material adverse effect on our
business, financial condition and results of operations.

In addition, the FDA has the authority to regulate the claims we make in
marketing our prescription drug products to ensure that such claims are true, not misleading, supported by scientific evidence and consistent with the labeled use of the drug. Failure to comply with FDA requirements in this regard could result in,
among other things, suspensions of approvals, seizures or recalls of products, injunctions against a products manufacture, distribution, sales and marketing, operating restrictions, civil penalties and criminal prosecutions.

Most of our core products contain narcotic ingredients. As a result of reports of misuse or abuse of prescription narcotics, the sale of such drugs may be subject to
new regulation, including the development and implementation of risk minimization action plans, which may prove difficult or expensive to comply with, and we and other pharmaceutical companies may face lawsuits.

Most of our core products contain narcotic ingredients. Misuse or abuse of such drugs can lead to
physical or other harm. For example, in the past two years, reportedly widespread misuse or abuse of OxyContin®, a product of Purdue Pharma L.P., or Purdue, containing the narcotic
oxycodone, resulted in the strengthening of warnings on its labeling. In addition, we believe that Purdue, the manufacturer of OxyContin®, faces or did face numerous lawsuits, including
class action lawsuits, related to OxyContin® misuse or abuse. On June 7, 2005, we began commercial sale of our oxycodone extended-release tablets, 10mg, 20mg, 40mg and 80mg strengths,
each bioequivalent versions of OxyContin®. Pursuant to a settlement agreement with Purdue, all sales of our oxycodone extended-release tablets ceased as of December 31, 2006. However,
we may be subject to litigation similar to the OxyContin® suits related to our generic version of OxyContin® or any other
narcotic containing product that we market.



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The FDA or the U.S. Drug Enforcement Administration, or DEA, may impose new regulations concerning the
manufacture, storage, transportation and sale of prescription narcotics. Such regulations may include new labeling requirements, the development and implementation of formal risk minimization action plans, restrictions on prescription and sale of
these products and mandatory reformulation of our products in order to make abuse more difficult. On September 27, 2007, Congress passed legislation authorizing the FDA to require companies to undertake post-approval studies in order to assess
known or signaled potential serious safety risks and to make any labeling changes necessary to address safety risks. Congress also empowered the FDA to require companies to formulate risk evaluation and mitigation strategies to ensure a drugs
benefits outweigh its risks In addition, state health departments and boards of pharmacy have authority to regulate distribution and may modify their regulations with respect to prescription narcotics in an attempt to curb abuse. In either case, any
such new regulations or requirements may be difficult and expensive for us to comply with, may delay our introduction of new products, may adversely affect our net sales and may have a material adverse effect on our business, results of operations
and financial condition.

The pharmaceutical industry is heavily regulated, which creates uncertainty about our ability to bring new products to market
and imposes substantial compliance costs on our business.

Federal, state and local governmental authorities in the United States,
principally the FDA, impose substantial requirements on the development, manufacture, labeling, sale, distribution, marketing, advertising, promotion and introduction of therapeutic pharmaceutical products through lengthy and detailed laboratory and
clinical testing and other costly and time-consuming procedures. The submission of an NDA or ANDA to the FDA alone does not guarantee that the FDA will grant approval to market the product. Satisfaction of FDA requirements typically takes a number
of years, varies substantially based upon the type, complexity and novelty of the pharmaceutical product and is subject to uncertainty. The NDA approval process for a new product varies in time, generally requiring a minimum of 10 months, but
could also take several years from the date of application. The timing for the ANDA approval process for generic products is difficult to estimate and can vary significantly.

NDA approvals, if granted, may not include all uses for which a company may seek to market a product. The FDA actively enforces regulations prohibiting
marketing of products for unapproved uses. The FDA also requires companies to undertake post-approval surveillance regarding their drug products and to report any adverse events. Failure to comply with applicable regulatory requirements in this
regard can result in, among other things, suspensions or withdrawals of approvals, seizures or recalls of products, injunctions against a products manufacture, distribution, sales and marketing, operating restrictions, civil penalties and
criminal prosecutions. Furthermore, changes in existing regulations or the adoption of new regulations could prevent us from obtaining, or affect the timing of, future regulatory approvals. The effect of government regulation may be to delay
marketing of our new products for a considerable period of time, to impose costly procedures upon our activities and to furnish a competitive advantage to larger companies that compete against us.

We cannot assure you that the FDA or other regulatory agencies will approve any products developed by us, on a timely basis, if at all, or, if granted,
that approval will not entail limiting the indicated uses for which we may market the product, which could limit the potential market for any of these products.

The current FDA standards of approving new pharmaceutical products are more stringent than those that were applied in the past. These standards were not applied to many established products currently on the market,
including certain opioid products. As a result, the FDA does not have as extensive safety databases on these products as on some products developed more recently. Accordingly, we believe the FDA has recently expressed an intention to develop such
databases for certain of these products, including many opioids.

In particular, the FDA has expressed interest in specific chemical
structures that may be present as impurities in a number of opioid narcotic active pharmaceutical ingredients, such as oxycodone, which based on certain structural characteristics and laboratory tests may indicate the potential for having mutagenic
effects.



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More stringent controls of the levels of these impurities have been required and may continue to be required for FDA approval of products containing these
impurities. Also, labeling revisions, formulation or manufacturing changes and/or product modifications may be necessary for new or existing products containing such impurities. The FDAs more stringent requirements together with any additional
testing or remedial measures that may be necessary could result in increased costs for, or delays in, obtaining approval for certain of our products in development. Although we do not believe that the FDA would seek to remove a currently marketed
product from the market unless such mutagenic effects are believed to indicate a significant risk to patient health, we cannot make any such assurance.

In addition, on September 27, 2007, Congress passed legislation authorizing the FDA to require companies to undertake post-approval studies in order to assess known or signaled potential serious safety risks and
to make any labeling changes necessary to address safety risks. Congress also empowered the FDA to require companies to formulate risk evaluation and mitigation strategies to ensure a drugs benefits outweigh its risks.

The FDA and the DEA have important and complementary responsibilities with respect to our business. The FDA administers an application and post-approval
monitoring process to assure that marketed products are safe, effective and consistently of uniform, high quality. The DEA administers registration, drug allotment and accountability systems to assure against loss and diversion of controlled
substances. Both agencies have trained investigators that routinely, or for cause, conduct inspections, and both have authority to enforce their statutory authority and regulations using administrative remedies as well as civil and criminal
sanctions.

The FDA regulates the facilities and procedures used to manufacture pharmaceutical products in the United States or for sale in
the United States. Such facilities must be registered with the FDA and all products made in such facilities must be manufactured in accordance with current good manufacturing practices, or cGMP, regulations enforced by the FDA.
Compliance with cGMP regulations requires the dedication of substantial resources and requires significant expenditures. The FDA periodically inspects our third party manufacturing facilities and procedures to assure compliance. The FDA may cause a
recall or withdrawal of product approvals if regulatory standards are not maintained. The FDA approval to manufacture a drug is site-specific. In the event an approved manufacturing facility for a particular drug is required by the FDA to cease or
curtail operations, or otherwise becomes inoperable, or the manufacturing contract applicable thereto terminates, obtaining the required FDA approval to manufacture such drug at a different manufacturing site could result in production delays, which
could adversely affect our business, results of operations and financial condition.

The stringent DEA regulations on our use of controlled
substances include restrictions on their use in research, manufacture, distribution and storage. A breach of these regulations could result in imposition of civil penalties, refusal to renew or action to revoke necessary registrations, or other
restrictions on operations involving controlled substances. See also The DEA limits the availability of the active ingredients used in many of our current products and products in development and, as a result, our procurement quota may
not be sufficient to meet commercial demand or complete clinical trials.

We cannot determine what effect changes in regulations or
legal interpretations, when and if promulgated, may have on our business in the future. Changes could, among other things, require expanded or different labeling, the recall or discontinuance of certain products, additional record keeping and
expanded documentation of the properties of certain products and scientific substantiation. Such changes, or new legislation, could have a material adverse effect on our business, financial condition and results of operations. On September 27,
2007, Congress enacted new requirements for testing drug products in children, which may increase the time and cost necessary for new drug development. In addition, in December 2003, Congress passed measures intended to speed the process by
which generic versions of brand name drugs are introduced to the market. Among other things, these measures are intended to limit regulatory delays of generic drug applications and penalize companies that reach certain types of agreements with
makers of brand name drugs to delay the introduction of generic versions. These changes could result in increased generic competition for our



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branded and generic products and could have a material adverse effect on our business, financial condition and results of operations. See If
generic manufacturers use litigation and regulatory measures to obtain approval for generic versions of our branded drugs, our sales may suffer. The evolving and complex nature of regulatory requirements, the broad authority and discretion of
the FDA and the generally high level of regulatory oversight results in a continuing possibility that from time to time, we will be adversely affected by regulatory actions despite ongoing efforts and commitment to achieve and maintain full
compliance with all regulatory requirements.

Timing and results of clinical trials to demonstrate the safety and efficacy of products as well as the
FDAs approval of products are uncertain.

Before obtaining regulatory approvals for the sale of any of our products, other than
generic products, we must demonstrate through preclinical studies and clinical trials that the product is safe and effective for each intended use. Preclinical and clinical studies may fail to demonstrate the safety and effectiveness of a product.
Even promising results from preclinical and early clinical studies do not always accurately predict results in later, large scale trials. A failure to demonstrate safety and efficacy would result in our failure to obtain regulatory approvals.

The rate of patient enrollment sometimes delays completion of clinical studies. There is substantial competition to enroll patients in
clinical trials for pain management products, and such competition has delayed clinical development of our products in the past. Delays in planned patient enrollment can result in increased development costs and delays in regulatory approval. In
addition, we rely on collaboration partners that may control or make changes in trial protocol and design enhancements that may also delay clinical trials. We cannot assure you that we will not experience delays or undesired results in these or any
other of our clinical trials.

We presently have three products in Phase III
clinical trials and three products in Phase II clinical trials. In September 2007, we received a non-approvable letter from FDA identifying deficiencies and asking for additional information pertaining to our supplemental New Drug Application (sNDA)
for Frova®(frovatriptan succinate) 2.5 mg tablets for the short-term (six days per menstrual cycle) prevention of menstrual migraine (MM). We
evaluated the points raised in the FDA notification, and we have determined that the appropriate course of action is to withdraw this sNDA without prejudice to refiling as afforded under 21 CFR 314.65. We notified the FDA of this withdrawal on
April 7, 2008. We are continuing to evaluate development opportunities for Frova for this indication and other related indications.

We cannot assure you that the FDA or other regulatory agencies will approve any products developed by us, on a timely basis, if at all, or, if granted, that such approval will not subject the marketing of our products to certain limits on
indicated use. Any limitation on use imposed by the FDA or delay in or failure to obtain FDA approvals of products developed by us would adversely affect the marketing of these products and our ability to generate product revenue, as well as
adversely affect the price of our common stock.

Before obtaining regulatory approvals for certain generic products, we must conduct
limited clinical or other trials to show comparability to the branded products. A failure to obtain satisfactory results in these trials would prevent us from obtaining required regulatory approvals.

The success of our acquisition and licensing strategy is subject to uncertainty and any completed acquisitions or licenses may reduce our earnings, be difficult to
integrate, not perform as expected or require us to obtain additional financing.

We regularly evaluate selective acquisitions and look
to continue to enhance our product line by acquiring rights to additional products and compounds. Such acquisitions may be carried out through the purchase of assets, joint ventures and licenses or by acquiring other companies. However, we cannot
assure you that we will be able to complete acquisitions that meet our target criteria on satisfactory terms, if at all. In particular, we may not be able to identify suitable acquisition candidates, and we may have to compete for acquisition
candidates.



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Our competitors may have greater resources than us and therefore be better able to complete acquisitions or may cause the ultimate price we pay for
acquisitions to increase. If we fail to achieve our acquisition goals, our growth may be limited.

Acquisitions may expose us to additional
risks and may have a material adverse effect on our profitability and cash flows. Any acquisitions we make may:



| |  |  | fail to accomplish our strategic objectives;
| | - |  | --------------------------------------------



| |  |  | not be successfully combined with our operations;
| | - |  | -------------------------------------------------



| |  |  | not perform as expected; and
| | - |  | ----------------------------



| |  |  | expose us to cross border risks.
| | - |  | --------------------------------

In
addition, based on current acquisition prices in the pharmaceutical industry, acquisitions could decrease our net income per share and add significant intangible assets and related amortization charges. Our acquisition strategy may require us to
obtain additional debt or equity financing, resulting in leverage, increased debt obligations as compared to equity, or dilution of ownership. We may not be able to finance acquisitions on terms satisfactory to us.

Further, if we are unable to maintain, on commercially reasonable terms, product, compound or other licenses that we have acquired, our ability to
develop or commercially exploit our products may be inhibited.

In January 2007,
following an assessment of the status of DepoDur®, we announced that we notified SkyePharma PLC, or SkyePharma, of our intent to terminate our development and commercialization agreement
for this product and, in February 2007, entered into a termination agreement with SkyePharma whereby the Development and Marketing Strategic Alliance Agreement terminated in its entirety on March 31, 2007. In order to provide for the continued
commercial support of the DepoDur® product and the transition of such product to SkyePharma on March 31, 2007, we provided a number of services and undertook certain activities.
Specifically, we employed commercially reasonable efforts to maintain and continue all U.S. commercial activities in support of DepoDur® through March 31, 2007, and supported and/or
undertook the transition of certain of our functions and activities (including third party activities) to SkyePharma that were useful and necessary for SkyePharma to assume commercial and related responsibilities for DepoDur® in the United States. All such transition services and activities were completed by March 31, 2007. During the year ended December 31, 2006, as a result of the continued lack of
commercial success of DepoDur® we recorded an impairment charge of $14.8 million related to the remaining unamortized portion of our SkyePharma intangible asset.

In addition, following an impairment review of SyneraTM, we determined that the carrying amount of the recorded intangible asset was not recoverable. As a result in 2006, we recorded a $16.5 million impairment charge to write down the
unamortized portion of this intangible asset to its anticipated fair value. During the year ended December 31, 2007, as a result of the continued lack of commercial success of SyneraTM, we recorded an impairment charge of $0.9 million related to the remaining unamortized portion of our ZARS intangible asset.

Our growth and development will depend on developing, commercializing and marketing new products, including both our own products and those developed with our collaboration partners. If we do not do so
successfully, our growth and development will be impaired.

Our future revenues and profitability will depend, to a significant extent,
upon our ability to successfully commercialize new branded and generic pharmaceutical products in a timely manner. As a result, we must continually develop, test and manufacture new products, and these new products must meet regulatory standards and
receive requisite regulatory approvals. Products we are currently developing may or may not receive the regulatory approvals necessary for us to market them. Furthermore, the development and commercialization process is time-consuming and costly,
and we cannot assure you that any of our products, if and when



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developed and approved, can be successfully commercialized. Some of our collaboration partners may decide to make substantial changes to a products
formulation or design, may experience financial difficulties or have limited financial resources, any of which may delay the development, commercialization and/or marketing of new products. In addition, if a co-developer on a new product terminates
our collaboration agreement or does not perform under the agreement, we may experience delays and, possibly, additional costs in developing and marketing that product.

We conduct research and development primarily to enable us to manufacture and market FDA-approved pharmaceuticals in accordance with FDA regulations. Much of our development effort is focused on technically
difficult-to-formulate products and/or products that require advanced manufacturing technology. Typically, research expenses related to the development of innovative compounds and the filing of NDAs for these products are significantly greater than
those expenses associated with ANDAs for generic products. As we continue to develop new products, our research expenses will likely increase. Because of the inherent risk associated with research and development efforts in our industry,
particularly with respect to new drugs, our research and development expenditures may not result in the successful introduction of FDA approved new pharmaceutical products. Also, after we submit an NDA or ANDA, the FDA may require that we conduct
additional studies, including, depending on the product, studies to assess the products interaction with alcohol, and as a result, we may be unable to reasonably predict the total research and development costs to develop a particular product.
Indeed, on September 27, 2007, Congress passed legislation authorizing the FDA to require companies to undertake post-approval studies in order to assess known or signaled potential serious safety risks and to make any labeling changes
necessary to address safety risks. Congress also empowered the FDA to require companies to formulate risk evaluation and mitigation strategies to ensure a drugs benefits outweigh its risks.

We face intense competition from brand-name companies that sell or license their own generic versions of our generic products or seek to delay the introduction of
generic products.

Brand-name pharmaceutical companies have taken aggressive steps to thwart competition from generic equivalents of
their brand-name products. In particular, brand-name companies sell directly to the generics market or license their products for sale to the generics market through licensing arrangements or strategic alliances with generic pharmaceutical companies
(so-called authorized generics). No significant regulatory approvals are currently required for a brand-name manufacturer to sell directly or through a third party to the generic market. Brand-name manufacturers do not face any other
significant barriers to entry into such market. The introductions of these so-called authorized generics have had and may continue to have an adverse effect by reducing our market share and adversely affecting our profitability and cash
flows.

In addition, brand-name companies continually seek new ways to delay generic introduction and decrease the impact of generic
competition, such as filing new patents on drugs whose original patent protection is about to expire; filing an increasing number of patents that are more complex and costly to challenge; filing suits for patent infringement that automatically delay
approval by the FDA; developing patented controlled release or other next generation products, which often reduces the demand for the generic version of the existing product for which we may be seeking approval; changing product claims and product
labeling; developing and marketing as over-the-counter products those branded products that are about to face generic competition; or filing Citizens Petitions with the FDA seeking restraints on our products or seeking to prevent them from
coming to market. These strategies may increase the costs and risks associated with our efforts to introduce generic products and may delay or prevent such introduction altogether.

We face intense competition from other manufacturers of generic versions of our generic products.

Our generic products compete with branded products and with generic versions made by or for other manufacturers, such as Mallinckrodt Inc. and Watson Pharmaceuticals, Inc. When additional versions of one of our generic products
enter the market, we generally lose market share and our selling prices and margins on the



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product decline. Because we are smaller than many of our full-line competitors in the generic pharmaceutical products sector, we may lack the financial and
other resources needed to maintain our profit margins and market share in this sector.

If the efforts of manufacturers of branded pharmaceuticals to
use litigation and legislative and regulatory means to limit the use of generics and certain other products are successful, our sales may suffer.

Pharmaceutical companies that produce patented brand products are increasingly employing a range of legal and regulatory strategies to delay the introduction of competing generics and certain other products to which
we do not have a right of reference to all necessary preclinical and clinical data. Opposing such measures can be costly and time-consuming and result in delays in the introduction of our products.

The products for which we are developing generic versions may be claimed by their manufacturer to be protected by one or more patents. If we file an ANDA
to seek FDA approval of our generic version of such a drug, we are required to certify that any patent or patents listed as covering the approved listed drug are invalid, unenforceable or will not be infringed by our generic version. Similar
certification requirements apply to new drug applications filed under Section 505(b)(2) of the Federal Food, Drug and Cosmetic Act, where we rely on information to which we do not have a right of reference. Once the FDA accepts our ANDA or
Section 505(b)(2) NDA, we are required to notify the brand manufacturer of this fact. The brand manufacturer then has 45 days from the receipt of the notice in which to sue us for patent infringement. If it does so, the FDA is generally
prevented from granting approval of the ANDA or Section 505(b)(2) NDA until the earliest of 30 months from the date the FDA accepted the application for filing, the conclusion of litigation in our favor (including through
appeal to any federal Court of Appeals) or expiration of the patent(s).

We may be the subject of product liability claims or product recalls,
and we may be unable to obtain or maintain insurance adequate to cover potential liabilities.

Our business exposes us to potential
liability risks that arise from the testing, manufacturing, marketing and sale of our products. In addition to direct expenditures for damages, settlement and defense costs, there is a possibility of adverse publicity as a result of product
liability claims. Product liability is a significant commercial risk for us. Some plaintiffs have received substantial damage awards in some jurisdictions against pharmaceutical companies based upon claims for injuries allegedly caused by the use of
their products. In addition, it may be necessary for us to recall products that do not meet approved specifications or which subsequent data demonstrate may be unsafe or ineffective, which would also result in adverse publicity, as well as resulting
in costs connected to the recall and loss of revenue.

We cannot assure you that a product liability claim or series of claims brought
against us would not have an adverse effect on our business, financial condition, and results of operations. If any claim is brought against us, regardless of the success or failure of the claim, we cannot assure you that we will be able to obtain
or maintain product liability insurance in the future on acceptable terms or with adequate coverage against potential liabilities or the cost of a recall.

The availability of third party reimbursement for our products is uncertain, and thus we may find it difficult to maintain current price levels. Additionally, the market may not accept those products for which third party reimbursement
is not adequately provided.

Our ability to commercialize our products depends, in part, on the extent to which reimbursement for the
costs of these products is available from government health care programs, private health insurers and others. We cannot assure you that third party payment for our products will be adequate for us to maintain price levels sufficient for realization
of an appropriate return on our investment. Government, private insurers and other third party payers are increasingly attempting to contain health care costs by (1) limiting both coverage and the level of reimbursement (including adjusting
co-pays) for products approved for marketing by the FDA, (2) refusing, in some cases, to provide any coverage for uses of approved products for indications for which the



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FDA has not granted marketing approval and (3) requiring or encouraging, through more favorable reimbursement levels or otherwise, the substitution of
generic alternatives to branded products.

On December 8, 2003, President Bush signed into law the Medicare Modernization Act of 2003.
The Medicare Modernization Act created a new prescription drug coverage program for people with Medicare through a new system of private market insurance providers; the program began in January 2006. This new benefit may result in an increased use
of formularies (listings of prescription drugs approved for use) such that, in the event a Medicare beneficiarys medications are not listed on the applicable formulary, such Medicare beneficiary may not receive reimbursement for such
medications. Moreover, once these formularies are established, Medicare will not be obligated to pay for drugs omitted from a formulary, and the cost of these non-covered drugs will not be counted towards the $3,600 annual out-of-pocket beneficiary
deductible established by the Medicare Modernization Act. Further, since 2006, Medicare prescription drug program beneficiaries are not permitted to purchase private insurance policies, known as Medigap policies, to cover the cost of
off-formulary medications. If our products are or become excluded from these new formularies, demand for our products might decrease and we may be forced to lower prices for our products, which may adversely affect our business and our results of
operations.

From time to time, state Medicaid programs review our products to
assess whether such products should be subject to a prior authorization process, which processes vary state-by-state but generally require physicians prescribing the products to answer several questions prior to the product being dispensed. The
institution of a prior authorization process may adversely impact the sales of the related product in the state and depending on the state, may adversely affect our business and results of operations. On February 20, 2008, in connection with
its Clinical Drug Review Program, the Pharmacy and Therapeutics Committee of the New York State Department of Health reviewed our product Lidoderm® and recommended that it be subject to a
prior authorization process. A final decision on this matter is not expected until the second half of 2008, but there can be no assurance that such a process, or the institution thereof, in New York State or elsewhere would not have a material
adverse effect on our business, financial condition and results of operations.

If government and third party payers do not provide
adequate coverage and reimbursement levels for users of our products, the market acceptance of these products could be adversely affected. In addition, the following factors could significantly influence the purchase of pharmaceutical products,
which would result in lower prices and a reduced demand for our products that might force us to reduce the price of these products to remain competitive:



| |  |  | the trend toward managed health care in the United States;
| | - |  | ----------------------------------------------------------



| |  |  | the growth of organizations such as HMOs and managed care organizations;
| | - |  | ------------------------------------------------------------------------



| |  |  | legislative proposals to reform health care and government insurance programs; and
| | - |  | ----------------------------------------------------------------------------------



| |  |  | price controls and non-reimbursement of new and highly priced medicines for which the economic therapeutic rationales are not established.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------

Our reporting and payment obligations under the Medicaid rebate program and other governmental pricing programs are complex and may
involve subjective decisions. Any failure to comply with those obligations could subject us to penalties and sanctions.

We are subject
to various federal and state laws pertaining to health care fraud and abuse, including prohibitions on the offer of payment or acceptance of kickbacks or other remuneration in return for the purchase of our products. Sanctions for violating these
laws include criminal penalties and civil sanctions and possible exclusion from the Medicare, Medicaid, and other government health care programs. There can be no assurance that our practices will not be challenged under these laws in the future or
that such a challenge would not have a material adverse effect on our business or results of operations.



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We also are subject to federal and state laws prohibiting the presentation (or the causing to be
presented) of claims for payment (by Medicare, Medicaid, or other third-party payers) that are determined to be false, fraudulent, or for an item or service that was not provided as claimed. These false claims statutes include the Federal Civil and
Criminal False Claims Acts, which allow any person to bring suit in the name of the government alleging false or fraudulent claims presented to or paid by the government (or other violations of the statutes) and to share in any amounts paid by the
entity to the government in fines or settlement. Such suits, known as qui tam actions, have increased significantly in the health care industry in recent years. These actions against health care companies may result in payment of fines or exclusion
from the Medicare, Medicaid, and/or other government health care programs.

We and other pharmaceutical companies are defendants in a
number of lawsuits filed by local and state government entities, alleging generally that we and numerous other pharmaceutical companies reported false pricing information in connection with certain drugs that are reimbursable under Medicaid. We
intend to defend these lawsuits vigorously. Depending on developments in the litigation however, as with all litigation, there is a possibility that we will suffer adverse decisions or verdicts of substantial amounts, or that we will enter into
monetary settlements in one or more of these actions. Any unfavorable outcomes as a result of such litigation could have a material adverse effect on our business, financial condition or results of operations.

Government regulations regarding reporting and payment obligations are complex and we are continually evaluating the methods we use to calculate and
report the amounts owed with respect to Medicaid and other government pricing programs. Our calculations are subject to review and challenge by various government agencies and authorities and it is possible that any such review could result either
in material changes to the method used for calculating the amounts owed to the pertinent government agency (or agencies), or to the amounts themselves. In addition, because our processes for these calculations and our judgments supporting these
calculations involve, and will continue to involve, subjective decisions, these calculations are subject to the risk of errors. As noted above, any governmental agency that commences an action, if successful, could impose, based on a claim of
violation of fraud and false claims laws or otherwise, civil and/or criminal sanctions, including fines, penalties and possible exclusion from federal health care programs (including Medicaid and Medicare). Some of the applicable laws impose
liability even in the absence of specific intent to defraud. Furthermore, should there be ambiguity with regard to how to properly calculate and report paymentsand even in the absence of such ambiguitya governmental authority may take a
position contrary to a position we have taken, and may impose civil and/or criminal sanctions. Any such penalties or sanctions could have a material adverse effect on our business, financial position and results of operations and could cause the
market value of our common stock to decline.

Once approved, there is no guarantee that the market will accept our future products, and regulatory
requirements could limit the commercial usage of our products.

Even if we obtain regulatory approvals, uncertainty exists as to whether
the market will accept our products. A number of factors may limit the market acceptance of our products, including the timing of regulatory approvals and market entry relative to competitive products, the availability of alternative products, the
price of our products relative to alternative products, the availability of third party reimbursement and the extent of marketing efforts by third party distributors or agents that we retain. We cannot assure you that our products will receive
market acceptance in a commercially viable period of time, if at all. We cannot be certain that any investment made in developing products will be recovered, even if we are successful in commercialization. To the extent that we expend significant
resources on research and development efforts and are not able, ultimately, to introduce successful new products as a result of those efforts, our business, financial position and results of operations may be materially adversely affected, and the
market value of our common stock could decline. In addition, many of our products contain narcotic ingredients that carry stringent record keeping obligations, strict storage requirements and other limitations on these products availability,
which could limit the commercial usage of these products.



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We sell our products to a limited number of wholesale drug distributors and large pharmacy chains. In
turn, these wholesale drug distributors and large pharmacy chains supply products to pharmacies, hospitals, governmental agencies and physicians. Net sales to customers who accounted for 10% or more of our net sales during the years ended
December 31, 2007, 2006 and 2005 were as follows:



|           |  |      |   |  |      |   |  |      |  
|---------- |  | ---- | - |  | ---- | - |  | ---- | -
|           |  | 2007 |   |  | 2006 |   |  | 2005 |  
|Customer A |  | 34   | % |  | 28   | % |  | 27   | %
|Customer B |  | 31   | % |  | 29   | % |  | 31   | %
|Customer C |  | 15   | % |  | 15   | % |  | 13   | %

If we were to lose the business of any of these customers, or if any were to experience difficulty
in paying us on a timely basis, our net sales, profitability and cash flows could be materially and adversely affected.

We are dependent on outside manufacturers for the manufacture of our products; therefore, we will have limited control of the manufacturing process and related costs. Certain of our manufacturers currently
constitute the sole source of one or more of our products, including Teikoku, our sole source of Lidoderm®.

Third party manufacturers currently manufacture all of our products pursuant to contractual arrangements. Certain of our manufacturers currently constitute the sole source of one or more of our products. Because of
contractual restraints and the lead-time necessary to obtain FDA approval, and possibly DEA registration, of a new manufacturer, replacement of any of these manufacturers may be expensive and time consuming and may cause interruptions in our supply
of products to customers. As a result, any such delay could have a material adverse effect on our business, financial condition or results of operations.

Because all of our products are manufactured by third parties, we have a limited ability to control the manufacturing process or costs related to this process. Increases in the prices we pay our manufacturers,
interruptions in our supply of products or lapses in quality could adversely impact our margins, profitability and cash flows. We are reliant on our third party manufacturers to maintain the facilities at which they manufacture our products in
compliance with FDA, DEA, state and local regulations. If they fail to maintain compliance with FDA, DEA or other critical regulations, they could be ordered to cease manufacturing which would have a material adverse impact on our business, results
of operations and financial condition. In addition to FDA and DEA regulation, violation of standards enforced by the Environmental Protection Agency, or EPA, and the Occupational Safety and Health Administration, or OSHA, and their counterpart
agencies at the state level, could slow down or curtail operations of third party manufacturers.

We have entered into minimum purchase
requirement contracts with some of our third party manufacturers. In May 2001, we entered into a long-term manufacturing and development agreement with Novartis Consumer Health, Inc., or Novartis, pursuant to which Novartis has agreed to
manufacture certain of our commercial products in addition to products in development. As of December 31, 2007, we are required to purchase a minimum of approximately $20 million of product from Novartis in 2008 and approximately $21 million
per year thereafter through December 31, 2010.

We also have a long-term
contract with Teikoku Seiyaku Co., Ltd., or Teikoku, under which Teikoku manufactures Lidoderm® at its Japanese facility for commercial sale by us in the United States. We have agreed
to purchase a minimum number of patches per year from Teikoku through 2012, representing the noncancelable portion of the Teikoku agreement. Teikoku has agreed to fix the supply price of Lidoderm® for a period of time after which the price will be adjusted at future set dates based on a price index defined in the Teikoku agreement. Since future price changes are unknown, we have used prices currently existing under the Teikoku
agreement, and estimated our minimum purchase requirement to be approximately $32 million per year through



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2012. The minimum purchase requirement shall remain in effect subsequent to 2012, except that we have the right to terminate the Teikoku agreement after
2012, if we fail to meet the annual minimum requirement.

In addition, we may consider entering into additional manufacturing arrangements
with third party manufacturers. In each case, we will incur significant costs in obtaining the regulatory approvals and taking the other steps necessary to begin commercial production by these manufacturers. If the market for the products
manufactured by these third parties substantially contracts or disappears, we will continue to be financially obligated under these contracts, an obligation which could have a material adverse effect on our business.

We are dependent on third parties to supply all raw materials used in our products and to provide services for certain core aspects of our business. Any interruption
or failure by these suppliers, distributors and collaboration partners to meet their obligations pursuant to various agreements with us could have a material adverse effect on our business, results of operations and financial condition.

We rely on third parties to supply all raw materials used in our products. In addition, we rely on third party suppliers, distributors
and collaboration partners to provide services for certain core aspects of our business, including manufacturing, warehousing, distribution, customer service support, medical affairs services, clinical studies, sales and other technical and
financial services. All third party suppliers and contractors are subject to FDA, and very often DEA, requirements. Our business and financial viability are dependent on the regulatory compliance of these third parties, and on the strength, validity
and terms of our various contracts with these third party manufacturers, distributors and collaboration partners. Any interruption or failure by these suppliers, distributors and collaboration partners to meet their obligations pursuant to various
agreements with us could have a material adverse effect on our business, financial condition and results of operations.

In addition, we
have entered into minimum purchase requirement contracts with some of our third party suppliers. If the market for the products that utilize these raw materials substantially contracts or disappears, we will continue to be financially obligated
under these contracts and meeting such obligations could have a material adverse effect on our business.

We are dependent upon third
parties to provide us with various estimates as a basis for our financial reporting. While we undertake certain procedures to review the reasonability of this information, we cannot obtain absolute assurance over the accounting methods and controls
over the information provided to us by third parties. As a result we are at risk of them providing us with erroneous data which could have a material adverse impact on our business.

The DEA limits the availability of the active ingredients used in many of our current products and products in development and, as a result, our procurement quota may not be sufficient to meet commercial demand or
complete clinical trials.

The DEA regulates chemical compounds as Schedule I, II, III, IV or V substances, with Schedule I
substances considered to present the highest risk of substance abuse and Schedule V substances the lowest risk. The active ingredients in some of our current products and products in development, including oxycodone, oxymorphone, morphine,
fentanyl, sufentanil and hydrocodone, are listed by the DEA as Schedule II or III substances under the Controlled Substances Act of 1970. Consequently, their manufacture, shipment, storage, sale and use are subject to a high degree of
regulation. For example, all Schedule II drug prescriptions must be signed by a physician, physically presented to a pharmacist and may not be refilled without a new prescription.

Furthermore, the DEA limits the availability of the active ingredients used in many of our current products and products in development and, as a result,
our procurement quota of these active ingredients may not be sufficient to meet commercial demand or complete clinical trials. We must annually apply to the DEA for procurement quota in order to obtain these substances. Any delay or refusal by the
DEA in establishing our procurement quota for controlled substances could delay or stop our clinical trials, product launches or could



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cause trade inventory disruptions for those products that have already been launched, which could have a material adverse effect on our business, financial
position and results of operations.

Patent litigation which is often time-consuming and expensive could have a material adverse effect on our business,
results of operations and financial condition.

The expense of patent litigation, whether or not we are successful, could have an
adverse effect on our business, results of operations and financial condition. Regardless of FDA approval, should we commence a lawsuit against a third party for patent infringement or should there be a lawsuit commenced against us with respect to
any alleged patent infringement by us, in either case, whether because of the filing of an ANDA or otherwise, the uncertainties inherent in patent litigation make the outcome of such litigation difficult to predict. The cost of such litigation as
well as the ultimate outcome of such litigation, if commenced, could have a material adverse effect on our business, results of operations and financial condition.

We invest in securities that are subject to market risk and the recent issues in the financial markets could adversely affect the value of our assets.

At March 31, 2008, $337.4 million of our marketable securities portfolio was invested in A, AA, and AAA rated investments in auction-rate debt securities. The $337.4 million represents our original par value
investment in these securities. Auction-rate securities are long-term variable rate bonds tied to short-term interest rates. After the initial issuance of the securities, the interest rate on the securities is reset periodically, at intervals
established at the time of issuance (e.g., every seven, twenty-eight, or thirty-five days; every six months; etc.), based on market demand for a reset period. Auction-rate securities are bought and sold in the marketplace through a competitive
bidding process often referred to as a Dutch auction. If there is insufficient interest in the securities at the time of an auction, the auction may not be completed and the rates may be reset to predetermined penalty or
maximum rates. Following such a failed auction, we would not be able to access our funds that are invested in the corresponding auction-rate securities until a future auction of these investments is successful or new buyers express
interest in purchasing these securities in between reset dates. Given the current negative liquidity conditions in the global credit markets, beginning in February 2008 and continuing through the date of this report, auctions for $327.4 million of
original par value of our auction-rate securities have failed rendering these securities currently illiquid through the normal auction process. Of this $327.4 million, $10.0 million of original par value securities have been called at 100% of par
value by the issuer with a call date of April 30, 2008. Through the date of this report, all of our auction-rate securities in which we invest remain A, AA, and AAA rated. Specifically, 3% of our auction-rate securities are A rated, 3% are AA rated
and 94% are AAA rated. In addition, during the first quarter of 2008 and continuing through the date of this report, we liquidated into cash equivalents, $259.2 million of auction-rate securities. The $259.2 million equaled our original purchase
value. The underlying assets of our auction-rate securities are student loans and municipal bonds. Student loans are insured by either the Federal Family Education Loan Program (FFELP), a combination of FFELP and other monoline insurers such as
Ambac Assurance Corp. (AMBAC) and MBIA Insurance Corp. (MBIA), or AMBAC. The municipal bonds are insured by AMBAC, MBIA, or Financial Security Assurance Inc. (FSA). As of April 28, 2008, AMBAC and MBIA were rated AAA by Moodys and
Standard and Poors, and AA by Fitch Ratings and FSA was rated AAA by Moodys, Standard and Poors, and Fitch Ratings. Although these insurers are highly rated, they are reported to be experiencing financial difficulty, which
could negatively affect their ratings and thus the ratings of the auction-rate securities that we hold. Any ratings downgrade or potential ratings downgrade could have a material adverse effect on our business, financial condition or results of
operations.

Our auction-rate securities continue to pay interest according to their stated terms. However, due to the lack of observable
market prices, we are currently evaluating whether our auction-rate securities have declined in value. Based on current information, it is possible that a portion of our auction-rate securities are impaired as of March 31, 2008. If it is
concluded that an impairment exists, we must evaluate if the decline in value is considered temporary or other-than-temporary. A temporary impairment will be recorded as an unrealized pre-tax loss in other comprehensive income and included as a
reduction in stockholders equity. Although there can



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be no assurance, we believe that any impairment charge would be considered temporary at this time due to the relatively short period of time and the extent
to which the fair value has been less than par, the financial condition and near-term prospects of the underlying issuers, and our intent and ability to retain our investment in the issuers for a period of time sufficient to allow for any
anticipated recovery in market value. At this point in time, we have the intent and ability to hold the securities over their anticipated recovery periods. Of course, there can be no assurance that our current belief that the securities will recover
their value will not change, at which time an other-than-temporary impairment could occur. An other-than-temporary impairment would be recorded in the statement of income. We anticipate finalizing the evaluation of our auction-rate securities
portfolio prior to the filing of our Quarterly Report on Form 10-Q for the quarter ended March 31, 2008. However, we currently expect a temporary impairment of these auction-rate securities of approximately $14 million. There can be no
assurance that the temporary impairment will not exceed such amounts.

The credit and capital markets have continued to deteriorate in
2008. If uncertainties in these markets continue, these markets deteriorate further or we experience any additional ratings downgrades on any investments in our portfolio (including on our auction-rate securities), we may incur additional
impairments in future periods, which could negatively affect our financial condition, cash flow or reported earnings.

Any of these events
could materially affect our results of operations and our financial condition. In the event we need to access these funds, we could be required to sell these securities at an amount below our original purchase value. However, based on our ability to
access our cash and cash equivalents and our other liquid investments, and our expected operating cash flows, we do not expect to be required to sell these securities at a loss. However, there can be no assurance that we will not have to sell these
securities at a loss.

Sales of our products may be adversely affected by the consolidation of the wholesale drug distribution and retail pharmacy
industries, a trend which may continue.

The network through which we sell our products has undergone significant consolidation marked
by mergers and acquisitions among wholesale distributors and the growth of large retail drug store chains. As a result, a small number of large wholesale distributors control a significant share of the market, and the number of independent drug
stores and small drug store chains has decreased. We expect that consolidation of drug wholesalers and retailers will place competitive pressures on drug manufacturers, including us. If we lose any of these customer accounts, or if our relationship
with them were to deteriorate, our business could also be materially and adversely affected. Orders for our products may increase or decrease depending on the inventory levels held by our major customers. Significant increases and decreases in
orders from our major customers could cause our operating results to vary significantly from quarter to quarter.

Retail availability of
our products is greatly affected by the inventory levels our customers hold. We monitor wholesaler inventory of our products using a combination of methods, including tracking prescriptions filled at the pharmacy level to determine inventory amounts
the wholesalers have sold to their customers. Pursuant to distribution service agreements with five of our significant wholesale customers, we receive inventory level reports. For other wholesalers where we do not receive inventory level reports,
however, our estimates of wholesaler inventories may differ significantly from actual inventory levels. Significant differences between actual and estimated inventory levels may result in excessive inventory production, inadequate supplies of
products in distribution channels, insufficient or excess product available at the retail level, and unexpected increases or decreases in orders from our major customers. Forward buying by wholesalers, for example, may result in significant and
unexpected changes in customer orders from quarter to quarter. These changes may cause our revenues to fluctuate significantly from quarter to quarter, and in some cases may cause our operating results for a particular quarter to be below our
expectations or internal projections. If our financial results are below expectations for a particular period, the market price of our securities may drop significantly.



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We may not be able to maintain our current insurance policies covering our business, assets, directors and officers
and product liability claims and we may not be able to obtain new policies in the future.

Property, product liability, directors
and officers and general liability insurance represent significant costs to us. Since the events of September 11, 2001, and due to recent concerns over corporate governance in the United States, corporate accounting scandals and product
liability lawsuits related to pharmaceuticals, liability and other types of insurance have become more difficult and costly to obtain. Unanticipated additional insurance costs could have a material adverse effect on our results of operations and
cash flows. There can be no assurance that we will be able to maintain our existing insurance policies or obtain new policies in meaningful amounts or at a reasonable cost. Any failure to obtain or maintain any necessary insurance coverage could
have a material adverse effect on our business, financial condition and results of operations.

If we are unable to retain our key personnel, and
continue to attract additional professional staff, we may be unable to maintain or expand our business.

Because of the specialized
scientific nature of our business, our ability to develop products and to compete with our current and future competitors will remain highly dependent, in large part, upon our ability to attract and retain qualified scientific, technical and
commercial personnel. The loss of key scientific, technical and commercial personnel or the failure to recruit additional key scientific, technical and commercial personnel could have a material adverse effect on our business. While we have
consulting agreements with certain key individuals and institutions and have employment agreements with our key executives, we cannot assure you that we will succeed in retaining personnel or their services under existing agreements. There is
intense competition for qualified personnel in the areas of our activities, and we cannot assure you that we will be able to continue to attract and retain the qualified personnel necessary for the development of our business.

We have significant goodwill and other intangible assets. Consequently, potential impairment of goodwill and other intangibles may significantly impact our
profitability.

Goodwill and other intangibles represent a significant portion of
our assets and stockholders equity. As of December 31, 2007, goodwill and other intangibles comprised approximately 15% of our total assets and 20% of our stockholders equity. Statement of Financial Accounting Standards
No. 142, Goodwill and Other Intangible Assets, prescribes a two-step method for determining goodwill impairment. In the first step, we determine the fair value of our one reporting unit. If the net book value of our reporting unit exceeds the
fair value, we would then perform the second step of the impairment test which requires allocation of our reporting units fair value to all of its assets and liabilities in a manner similar to a purchase price allocation, with any residual
fair value being allocated to goodwill. An impairment charge will be recognized only when the implied fair value of our reporting units goodwill is less than its carrying amount. Our other intangible assets, consisting of licenses and patents,
are assessed for impairment, in accordance with Statement of Financial Accounting Standards No. 144, Accounting for the Impairment or Disposal of Long-Lived Assets, whenever events or changes in circumstances indicate the carrying amount of the
asset may not be recoverable. The impairment testing involves comparing the carrying amount of the asset to the forecasted undiscounted future cash flows of the product. In the event the carrying value of the asset exceeds the undiscounted future
cash flows of the product and the carrying value is not considered recoverable, impairment exists. An impairment loss is measured as the excess of the assets carrying value over its fair value, calculated using a discounted future cash flow
method. An impairment loss would be recognized in net income in the period that the impairment occurs. During the year ended December 31, 2007, as a result of the continued lack of commercial success of SyneraTM, we recorded an impairment charge of $0.9 million related to the remaining unamortized portion of our ZARS intangible asset. During the fourth quarter of 2006, we recorded
impairment charges of $31.3 million related to certain intangible assets for SyneraTMand DepoDur®.

Events giving rise to impairment are an inherent risk in the pharmaceutical industry and cannot be
predicted. As a result of the significance of goodwill and other intangible assets, our results of operations and financial position in a future period could be negatively impacted should an impairment of goodwill or other intangible assets occur.



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We are a holding company with no operations.

We are a holding company with no direct operations. Our principal assets are the equity interests we hold in our operating subsidiaries. As a result, we
are dependent on loans, dividends and other payments from our subsidiaries to generate the funds necessary to meet our financial obligations. Our subsidiaries are legally distinct from us and have no obligation to make funds available to us.

Our revenues and operating results may fluctuate in future periods and we may fail to meet expectations, which may cause the price of our common stock
to decline.

Our quarterly operating results are difficult to predict and may
fluctuate significantly from period to period. Accordingly, one cannot predict our quarterly financial results based on our full-year financial guidance. We cannot predict with certainty the timing or level of sales of our products in the future. If
our quarterly sales or operating results fall below the expectations of investors or securities analysts, the price of our common stock could decline substantially. Our operating results may fluctuate due to various factors including those set forth
above. As a result of these factors, we believe that period-to-period comparisons of our operating results are not a good indication of our future performance. For example, our 2008 guidance is based upon our assumptions that our sales of
Lidoderm®, Opana® and Opana® ER and Frova® will grow over the course of the year, but there can be no assurance that sales of these products will grow at the rates anticipated, or at all.

Our stock price may be volatile, and your investment in our common stock could decline in value.

The
market prices for securities of healthcare companies in general have been highly volatile and may continue to be highly volatile in the future. Within the last 12 months through December 31, 2007, our stock has traded between $26.04 and
$35.85 per share. The following factors, in addition to other risk factors described in this section, may cause the market price of our common stock to change:



| |  |  | FDA approval or disapproval of any of the drug applications we have submitted;
| | - |  | ------------------------------------------------------------------------------



| |  |  | the success or failure of our clinical trials;
| | - |  | ----------------------------------------------



| |  |  | new data or new analyzes of older data that raises potential safety or effectiveness issues concerning our approved products;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------



| |  |  | competitors announcing technological innovations or new commercial products;
| | - |  | ----------------------------------------------------------------------------



| |  |  | introduction of generic substitutes for our products, including the filing of ANDAs with respect to generic versions of
our branded products, including Lidoderm®;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | developments concerning our or others proprietary rights, including patents;
| | - |  | -----------------------------------------------------------------------------



| |  |  | competitors publicity regarding actual or potential products under development;
| | - |  | --------------------------------------------------------------------------------



| |  |  | regulatory developments in the United States and foreign countries, or announcements relating to these matters;
| | - |  | ---------------------------------------------------------------------------------------------------------------



| |  |  | period-to-period fluctuations in our financial results;
| | - |  | -------------------------------------------------------



| |  |  | new legislation in the United States relating to the sale or pricing of pharmaceuticals;
| | - |  | ----------------------------------------------------------------------------------------



| |  |  | a determination by a regulatory agency that we are engaging or have engaged in inappropriate sales or marketing activities, including promoting the
off-label use of our products;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | litigation; and
| | - |  | ---------------



| |  |  | economic and other external factors, including disasters and other crises.
| | - |  | --------------------------------------------------------------------------



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If our stockholders sell substantial amounts of our common stock, the market price of our common stock may fall.

If our stockholders sell substantial amounts of our common stock, including shares issued upon the exercise of outstanding options, the
market price of our common stock may fall. These sales also may make it more difficult for us to sell equity or equity-related securities in the future at a time and price that we deem appropriate.

Of the 4,336,052 shares that may be issued upon the exercise of options outstanding as of December 31, 2007, 1,795,021 are vested, currently
exercisable and eligible for sale.

We have not paid, and may not pay, dividends and therefore, unless our stock appreciates in value, investors in our
stock may not benefit from holding our stock.

We have not paid any cash dividends since our inception. The payment of cash dividends is
subject to the discretion of our Board of Directors and will be dependent on many factors, including our earnings, capital needs and general financial condition. Further, should we enter into a new credit facility with a third party lender, it is
possible that the lender would limit or restrict the payment of dividends. We anticipate that, for the foreseeable future, we will retain our earnings in order to finance investments in our business. As a result, investors in our stock may not be
able to benefit from owning our stock unless the shares that these investors acquire appreciate in value.

We are exposed to risks if we are unable to
comply with changes to laws affecting public companies, including the Sarbanes-Oxley Act of 2002, and also to increased costs associated with complying with such laws.

Recently enacted and any future changes to the laws and regulations affecting public companies, including the provisions of the Sarbanes-Oxley Act of 2002 in the United States, will cause us to incur increased costs
as we evaluate the implications of new rules and respond to new requirements. Delays or a failure to comply with the new laws, rules and regulations could result in enforcement actions, the assessment of other penalties and civil suits. The new laws
and regulations make it more expensive for us under indemnities provided by us to our officers and directors and may make it more difficult for us to obtain certain types of insurance, including liability insurance for directors and officers; as
such, we may be forced to accept reduced policy limits and coverage or incur substantially higher costs to obtain the same or similar coverage. The impact of these events could also make it more difficult for us to attract and retain qualified
persons to serve on our Board of Directors, or as executive officers. We may be required to hire additional personnel and utilize additional outside legal, accounting and advisory services  all of which could cause our general and
administrative costs to increase beyond what we currently have planned.

Our operations could be disrupted if our information systems fail or if we are
unsuccessful in implementing necessary upgrades.

Our business depends on the efficient and uninterrupted operation of our computer and
communications systems and networks, hardware and software systems and our other information technology. If our systems were to fail or we are unable to successfully expand the capacity of these systems, or we are unable to integrate new
technologies into our existing systems, our operations and financial results could suffer.

The publication of negative results of studies or clinical
trials may adversely impact our sales revenue.

From time to time, studies or clinical trials on various aspects of pharmaceutical
products are conducted by academics or others, including government agencies. The results of these studies or trials, when published, may have a dramatic effect on the market for the pharmaceutical product that is the subject of the study. The
publication of negative results of studies  or clinical trials related to our products or the therapeutic areas in



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which our products compete  could adversely affect our sales, the prescription trends for our products and the reputation of our products. In
the event of the publication of negative results of studies or clinical trials related to our products or the therapeutic areas in which our products compete, our business, financial condition and results of operations could be materially adversely
affected. In addition, on September 27, 2007, Congress enacted requirements that the results of studies and clinical trials be provided by the investigator to the National Institutes of Health (NIH) for inclusion in a publicly-available
database registry of clinical trials. There is an exception for clinical research performed on behalf of a sponsor who has not yet submitted an NDA in connection with the drug being studied, however, it is unclear what impact the potential
publication of clinical research data for our products will have.

Actions that may be taken by significant stockholders may divert the time and
attention of our board of directors and management from our business operations.

Campaigns by significant investors to effect changes
at publicly traded companies have increased in recent years. Affiliates of D.E. Shaw & Co., L.P., which collectively beneficially own approximately 13.2 million shares of our outstanding common stock as of April 28, 2008, have sent letters
to our Board of Directors suggesting, among other things, that the Company begin a process of evaluating strategic alternatives and explore a recapitalization. In addition, D.E. Shaw has conveyed to certain of our board members that it is reserving
its right to seek minority representation on our Board of Directors. D.E. Shaw may, therefore, seek to solicit proxies directly from the Companys stockholders for our 2008 Annual Meeting. The Company has recently discussed, and is continuing
to discuss, with D.E. Shaw the possible nomination of an independent unaffiliated person recommended by D.E. Shaw to our Board of Directors. If a proxy contest were to be pursued by D.E. Shaw or any stockholder it could result in substantial expense
to the Company and consume significant attention of our management and Board of Directors. In addition, there can be no assurance that any stockholder will not pursue actions to effect changes in the management and strategic direction of the
Company, including through the solicitation of proxies from the Companys stockholders.

PART II



|Item 5. | Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities
|------- | ------------------------------------------------------------------------------------------------------------

Market Information.Our common stock is traded on the NASDAQ under the symbol ENDP. The following table sets forth the quarterly high
and low share price information for the periods indicated. The prices shown represent quotations between dealers, without adjustment for retail markups, markdowns or commissions, and may not represent actual transactions.



|                              |  |                  |       |     |   |      
|----------------------------- |  | ---------------- | ----- | --- | - | -----
|                              |  | Endo CommonStock
|                              |  | High             |       | Low
|Year Ending December 31, 2007 |  |                  |       |     |   |      
|1st Quarter                   |  | $                | 32.63 |     | $ | 26.91
|2nd Quarter                   |  | $                | 35.85 |     | $ | 28.94
|3rd Quarter                   |  | $                | 35.20 |     | $ | 28.86
|4th Quarter                   |  | $                | 30.90 |     | $ | 26.04
|Year Ending December 31, 2006 |  |                  |       |     |   |      
|1st Quarter                   |  | $                | 33.96 |     | $ | 21.06
|2nd Quarter                   |  | $                | 33.03 |     | $ | 27.76
|3rd Quarter                   |  | $                | 34.60 |     | $ | 28.88
|4th Quarter                   |  | $                | 34.75 |     | $ | 26.68

Holders. As of April 7, 2008, we estimate that there were approximately 71 record
holders of our common stock.



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Dividends.We have never declared or paid any cash dividends on our capital stock. Prior to its
expiration on December 21, 2006, our credit facility contained limitations and restrictions on the payment of dividends. Since these restrictions have lapsed, the payment of cash dividends is subject to the discretion of our Board of Directors
and will be dependent on many factors, including our earnings, capital needs and general financial condition. Further, should we enter into a new credit facility with a third party lender, it is possible that the lender would limit or restrict the
payment of dividends. We anticipate that, for the foreseeable future, we will retain our earnings in order to finance investments in our business.



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Performance Graph. The following graph provides a comparison of the cumulative total stockholder
return on the Companys common stock with that of the cumulative total stockholder return on the (i) NASDAQ Stock Market Index (U.S.) and (ii) the NASDAQ Pharmaceutical Index, commencing on December 31, 2002 and ending
December 31, 2007. The graph assumes $100 invested on December 31, 2002 in the Companys common stock, and in each of the comparative indices. Our historic stock price performance is not necessarily indicative of future stock price
performance.

LOGO



|                                  |  |              |        |      |   |        |  |      |        |      |   |        |  |   |        |  |   |       
|--------------------------------- |  | ------------ | ------ | ---- | - | ------ |  | ---- | ------ | ---- | - | ------ |  | - | ------ |  | - | ------
|                                  |  | December 31,
|                                  |  | 2002         |        | 2003 |   | 2004   |  | 2005 |        | 2006 |   | 2007  
|Endo Pharmaceutical Holdings Inc. |  | $            | 100.00 |      | $ | 251.46 |  | $    | 272.89 |      | $ | 393.04 |  | $ | 358.23 |  | $ | 346.41
|NASDAQ Composite Index            |  | $            | 100.00 |      | $ | 149.75 |  | $    | 164.64 |      | $ | 168.60 |  | $ | 187.83 |  | $ | 205.22
|NASDAQ Pharmaceutical Index       |  | $            | 100.00 |      | $ | 144.89 |  | $    | 160.46 |      | $ | 160.65 |  | $ | 163.42 |  | $ | 154.46

The information included under the heading Performance Graph in Item 5
of this Annual Report on Form 10-K is furnished and not filed and shall not be deemed to be soliciting material or subject to Regulation 14A, shall not be deemed filed for purposes of
Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the
Securities Exchange Act of 1934, as amended.



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PART III



|Item 10. | Directors, Executive Officers and Corporate Governance
|-------- | ------------------------------------------------------

The Board of Directors

The Amended and Restated Certificate of Incorporation of the Company provides
that the number of directors of the Company shall be not less than seven nor more than eleven, the exact number of which shall be fixed from time to the time by resolution of the Board of Directors or by a resolution adopted by holders of a majority
of the Companys Common Stock. As of April 29, 2008, the Board of Directors is currently fixed at seven members.

Directors need
not be stockholders of the Company or residents of the State of Delaware. Directors are elected for a one-year term and generally hold office until the next directors have been duly elected and qualified. Directors may receive compensation for their
services as determined by the Board of Directors. See 2007 Compensation of Directors. A vacancy on the Board, or a newly created directorship resulting from any increase in the authorized number of directors, may be filled by a
majority of the directors then in office, even though less than a quorum remains. A director appointed to fill a vacancy remains a director until his or her successor is elected by the stockholders at the next annual meeting or until his or her
successor is duly elected and qualified, or until his or her earlier death, resignation or removal.

Between January 1, 2007 and
December 31, 2007, the Board of Directors as a whole met fourteen times and acted by written consent on two occasions. All members of the Board of Directors attended more than 75% of the aggregate of all meetings of the Board of Directors and
of the Committees of the Board of Directors on which they served in 2007.

Set forth below are the principal occupation and certain other
information about each of the Companys current directors as of April 29, 2008.

JOHN J. DELUCCA, 65, is currently a
Director of Endo. Mr. Delucca was executive vice president and chief financial officer of the REL Consultancy Group until his retirement in 2004. Prior to that, he served as chief financial officer and executive vice president,
finance & administration, of Coty, Inc., from 1999 to 2002. From 1993 to 1999, he was senior vice president and treasurer of RJR Nabisco, Inc. During his career, he also served in executive positions for Hascoe Associates, Inc., The
Lexington Group, the Trump Group, International Controls Corp., and Textron, Inc. Mr. Delucca is currently a non-executive director and chairs the audit committee of ITC Deltacom. He also serves as a non-executive director, deputy chairman of
the audit committee, and a member of both the nominating and governance committee and the risk review committee of British Energy PLC and a non-executive director and member of the nominating and governance committee of Tier Technologies, Inc.

MICHEL DE ROSEN, 57, is currently a Director of Endo. Mr. de Rosen is currently Chief Executive Officer of Saint-Gobain
Desjonqueres in France, a position he has held since March 31, 2008. Mr. de Rosen is also currently Chairman of the Board of Directors of ViroPharma Incorporated, a position he has held since September 2002. Until March 31, 2008, in
addition to serving as Chairman of the Board of Directors, Mr. de Rosen served as President and Chief Executive Officer of ViroPharma Incorporated since August 2000, and as a Director since May 2000. From 1993 to 1999, he held several key
positions in Rhone-Poulenc Pharma and Rhone-Poulenc Rorer (now Sanofi-Aventis), including Chairman and Chief Executive Officer from May 1995 until December 1999. He began his career at the French Ministry of Finance and subsequently served in
several leading government positions. He also served in various executive roles in industry prior to 1993. Mr. de Rosen also is a Director of ABB Ltd.



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DAVID P. HOLVECK, 62, is President, Chief Executive Officer and a Director of Endo. Prior to
joining Endo in April 2008, Mr. Holveck was President of Johnson & Johnson Development Corporation and Vice President, Corporate Development of Johnson & Johnson since 2004. Mr. Holveck joined Johnson & Johnson
as a company Group Chairman in 1999, following the acquisition of Centocor, Inc. by Johnson & Johnson. Mr. Holveck was Chief Executive Officer of Centocor, Inc. at the time of the acquisition. Mr. Holveck joined Centocor in 1983
and progressed through various executive positions. In 1992, he assumed the role of President and Chief Operating Officer and later that year was named President and Chief Executive Officer. Prior to joining Centocor, he had held positions at
General Electric Company, Corning Glass Works and Abbott Laboratories. Mr. Holveck is a member of the Board of Trustees for The Fund for West Chester University, the Board of Directors of the Eastern Technology Council and Cleveland
Clinics Industrial Advisory Board.

GEORGE F. HORNER III, 63, is currently a Director of Endo. Mr. Horner is the
President and Chief Executive Officer of Prestwick Pharmaceuticals, Inc. He was the President and Chief Executive Officer and a member of the Board of Directors of Vicuron Pharmaceuticals Inc. from 1996 until its acquisition by Pfizer Inc. in
September 2005. Prior to joining Vicuron, he was Corporate Vice President of Ligand Pharmaceuticals from 1993 to 1995. He also served in a number of executive positions during his 17 years at Abbott Laboratories from 1976 to 1993, including
President, Canada; Regional Director, Latin America; General Manager, Mexico; General Manager, Southern Africa Region; and Regional Manager, Southeast Asia. Mr. Horner began his career in the pharmaceutical industry at E.R. Squibb, Inc., where
he served in a number of sales and product management positions.

MICHAEL HYATT, 62, is currently a Director of Endo. Mr. Hyatt
had been a director of Algos Pharmaceutical Corporation since November 1996 and became a director of Endo following its merger with Algos in July 2000. For more than five years, Mr. Hyatt has been a Senior Managing Director of Bear
Stearns & Co., Inc.

ROGER H. KIMMEL, 61, is currently Chairman of the Board of Endo. Mr. Kimmel became Chairman of
the Board upon the retirement of founder Carol A. Ammon on May 30, 2007. Mr. Kimmel had been a Director of Algos Pharmaceutical Corporation since July 1996 and became a Director of Endo following its merger with Algos in July 2000.
Mr. Kimmel has been Vice Chairman of Rothschild Inc., an investment banking firm, since January 2001. Previously, Mr. Kimmel was a partner of the law firm Latham & Watkins for more than five years. Mr. Kimmel is also a
director of Schiff Nutrition International, Inc.

CLIVE A. MEANWELL, M.D., Ph.D., 50, is currently a Director of Endo. Since July
2005, Dr. Meanwell has been the chairman and chief executive officer of The Medicines Company, a pharmaceutical company based in Parsippany, New Jersey, since 2001. From September 2001 through July 2005, Dr. Meanwell was the Executive
Chairman of The Medicines Company. Previously, he served as chairman, chief executive officer and president since the inception of The Medicines Company in 1996. From 1995 to 1996, Dr. Meanwell was a partner and managing director at MPM Capital
L.P., a venture capital firm. Prior to that, he held various positions of increasing scope and responsibility at Hoffman-La Roche, Inc. from 1986 to 1995, most recently as senior vice president.

Executive Officers

Set forth below are the names of,
and certain biographical information regarding, current executive officers of the Company who do not serve as directors of the Company, as of April 29, 2008.

IVAN GERGEL, M.D., 47, is Executive Vice President, Research and Development as of April 29, 2008. Prior to joining Endo in April 2008, Dr. Gergel was Senior Vice President of Scientific Affairs and
President of the Forest Research Institute of Forest Laboratories Inc., from 2005 through 2008. Prior to that, Dr. Gergel served as Vice President and Chief Medical Officer at Forest and Executive Vice President of the Forest



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Research Institute. He joined Forest in 1998 as Executive Director of Clinical Research following nine years at SmithKline Beecham and was named Vice
President of Clinical Development and Clinical Affairs in 1999. Dr. Gergel received his M.D. from The Royal Free Medical School of The University of London and an MBA from the Wharton School.

JOYCE N. LAVISCOUNT, 46, is Chief Accounting Officer of Endo. Prior to August 2006, Ms. LaViscount was Vice President of Financial Planning
and Analysis of Endo. Prior to joining Endo, Ms. LaViscount held positions of increasing scope and responsibility at Pfizer, Inc. (formerly Pharmacia Corporation) in Peapack, New Jersey in both the pharmaceutical and consumer healthcare groups.
Prior to joining Pharmacia, Ms. LaViscount held various positions at Bristol-Myers Squibb Company in Princeton, New Jersey, ranging from Senior Accountant to Senior Manager, Financial Analysis. Ms. LaViscount began her career in public
accounting with Ernst & Young.

DAVID A. H. LEE, M.D. Ph.D., 58, is Chief Scientific Officer of Endo. Prior to December
2006, Dr. Lee was Executive Vice President, Research & Development and Chief Scientific Officer of Endo. Prior to joining Endo in December 1997, Dr. Lee was Executive Vice President, Research and Development for CoCensys, Inc., an
emerging pharmaceuticals company based in Irvine, California, from 1992 through 1997. Prior to joining CoCensys, Dr. Lee held various positions at Solvay Pharmaceuticals in the Netherlands, ranging from head of global clinical development
programs to his final position as Vice President, Research and Development. Dr. Lee received his M.D. and Ph.D. degrees from the University of London and specialized in internal medicine and gastroenterology, prior to joining the pharmaceutical
industry.

CAROLINE B. MANOGUE, 39, is Executive Vice President, Chief Legal Officer and Secretary of Endo. Prior to April 2004,
Ms. Manogue was Senior Vice President, General Counsel and Secretary of Endo. Prior to joining Endo in September 2000, Ms. Manogue was an Associate at the law firm Skadden, Arps, Slate, Meagher and Flom LLP since 1995.

CHARLES A. ROWLAND, JR., 49, is Executive Vice President, Chief Financial Officer of Endo. Prior to joining Endo in December 2006,
Mr. Rowland was Senior Vice President and CFO of Biovail Pharmaceuticals, Inc., in Bridgewater, New Jersey. He was Chief Operating and Financial Officer for Breakaway Technologies, a management consulting company, from 2001 to 2004. His
pharmaceutical industry career includes positions of increasing scope and responsibility at Pharmacia Corp., where he had global responsibility for Finance and Information Technology for the Pharmaceutical Business and financial responsibility for
the Global Supply organization as Vice President, Finance Global Supply and VP Finance & IT-Global Pharma Ops; Novartis Pharmaceuticals Corp., where he was Vice President, Planning and Decision Support, and Bristol-Myers Squibb, where he
served as Director of Finance.

NANCY J. WYSENSKI, 50, is Chief Operating Officer of Endo. Prior to joining Endo in September 2007,
Ms. Wysenski was President of EMD Pharmaceuticals, Inc., the U.S. subsidiary of Merck KGaA. Before joining and co-founding EMD as Vice President of Marketing and Sales in 1999, she served as Senior Vice President of Operations at NetGenics, a
venture capital-backed, start-up company specializing in technologies for use in drug discovery. Prior to that, Ms. Wysenski held a number of positions of increasing scope and responsibility at Astra Merck, culminating as Vice President of
Sales. During her tenure at Astra Merck, she also served on the companys operating board. Prior to joining Astra Merck in 1990, she began her pharmaceutical industry career in 1984 at Merck Human Health, where she held various positions.



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Code of Conduct

The Board of Directors has adopted a Code of Conduct that applies to the Companys directors, executives (including its chief executive officer, chief financial officer and chief accounting officer) and
employees. The Code is posted on the Companys website at www.endo.com, under Investors-Corporate Governance.

Common Stock
Ownership Guidelines

The Board of Directors has adopted stock ownership guidelines (the Ownership Guidelines) both for
non-employee Directors and for executive officers and senior management of the Company (collectively Executive Management). The Board of Directors approved the Ownership Guidelines on February 20, 2008. The Board believes that
non-employee directors and Executive Management should have a significant equity position in the Company and that the Ownership Guidelines will serve to further the Boards interest in encouraging a longer-term focus in managing the Company.
The Board also believes that the Ownership Guidelines align the interests of its directors and Executive Management with the interests of stockholders and further promote Endos commitment to sound corporate governance. The Ownership Guidelines
are posted on the Companys website at www.endo.com, under Investors-Corporate Governance.

Section 16(a) Beneficial
Ownership Reporting Compliance

Section 16(a) of the Securities Exchange Act of 1934 requires our executive officers, directors and
greater-than-ten-percent stockholders (collectively, Reporting Persons) to file an initial report of ownership (Form 3) and reports of changes of ownership (Forms 4 and 5) of Endo securities with the SEC and the NASDAQ.
These persons are also required to furnish the Company with copies of all Section 16(a) reports that they file with respect to Endo securities. Based solely upon a review of Section 16(a) reports furnished to the Company for the fiscal
year ended December 31, 2007 and written representations from certain Reporting Persons that no other reports were required, the Company believes that, all the Reporting Persons complied with all applicable filing requirements for the fiscal
year ended December 31, 2007.

Committees of the Board of Directors and Related Reports

The Board of Directors has a standing Audit Committee, Compensation Committee, Nominating & Governance Committee and Transactions Committee, the
respective members and functions of which are described below.

Audit Committee

The Audit Committee is responsible for overseeing the Companys financial reporting process on behalf of the Board of Directors. In addition, the
Audit Committee reviews, acts on and reports to the Board of Directors with respect to various auditing and accounting matters, including the selection of the Companys independent registered public accounting firm, the scope of the annual
audits, fees to be paid to the independent registered public accounting firm, the performance of the Companys independent registered public accounting firm and the accounting practices of the Company and the Companys internal controls
and legal compliance functions. The Audit Committee operates pursuant to a written charter adopted by the Board of Directors, which is available on the Companys website at www.endo.com, under Investors-Corporate Governance.
The charter describes the nature and scope of responsibilities of the Audit Committee.

Management of the Company has the primary
responsibility for the Companys financial reporting process, principles and internal controls as well as preparation of its financial statements. The Companys independent registered public accounting firm is responsible for performing an
independent audit of the



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Companys financial statements and expressing an opinion as to the conformity of such financial statements with accounting principles generally accepted
in the United States.

Messrs. Delucca, Horner and Kimmel currently serve as members of the Audit Committee. Between January 1,
2007 and December 31, 2007, the Audit Committee met thirteen times, including periodic meetings held separately with management, the Companys internal auditors and the independent registered public accounting firm. The Board has elected
Mr. Delucca as Chair of the Audit Committee. The Board has determined that Mr. Delucca is a financial expert, as defined by the U.S. Securities and Exchange Commission (the SEC) regulations, and he has the
related financial management expertise within the meaning of the NASDAQ rules. The Board of Directors has determined that Messrs. Delucca, Horner and Kimmel are independent and financially literate in accordance with the criteria
established by the SEC and the NASDAQ.

Audit Committee Report

The Audit Committee has reviewed and discussed the Companys audited consolidated financial statements as of and for the year ended December 31,
2007 with the management of the Company and Deloitte & Touche LLP, the Companys independent registered public accounting firm. Further, the Audit Committee has discussed with Deloitte & Touche LLP the matters required to be
discussed under auditing standards generally accepted in the United States, including those matters set forth in the Statement of Auditing Standards No. 61, as amended, other standards of the Public Company Accounting Oversight Board (United
States), rules of the SEC, and other applicable regulations, relating to the firms judgment about the quality, not just the acceptability, of the Companys accounting principles, the reasonableness of significant judgments and estimates,
and the clarity of disclosures in the consolidated financial statements.

The Audit Committee also has received the written disclosures and
the letter from Deloitte & Touche LLP required by Independence Standards Board Standard No. 1 (Independence Discussions with Audit Committees), as currently in effect, that relate to Deloitte & Touche LLPs
independence from the Company, and has discussed with Deloitte & Touche LLP their independence from the Company. The Audit Committee has also considered whether the independent registered public accounting firms provision of non-audit
services to the Company is compatible with maintaining the firms independence. The Audit Committee has concluded that the independent registered public accounting firm is independent from the Company and its management. The Audit Committee has
also discussed with management of the Company and Deloitte & Touche LLP such other matters and received such assurances from them as it has deemed appropriate.

The Committee also reviewed managements report on its assessment of the effectiveness of the Companys internal control over financial reporting and the independent registered public accounting firms
report on managements assessment and the effectiveness of the Companys internal control over financial reporting. In addition, the Audit Committee reviewed key initiatives and programs aimed at strengthening the effectiveness of the
Companys internal and disclosure control structure. As part of this process, the Audit Committee continued to monitor the scope and adequacy of the Companys internal auditing program.

Based on the reviews, reports and discussions referred to above, the Audit Committee recommended to the Board of Directors, and the Board approved, that
the Companys audited consolidated financial statements for the year ended December 31, 2007 and managements assessment of the effectiveness of the Companys internal control over financial reporting be included in the
Companys Annual Report on Form 10-K for the year ended December 31, 2007, for filing with the SEC. The Audit Committee has selected, and the Board of Directors has ratified, subject to stockholder approval, the selection of the
Companys independent registered public accounting firm for the year ended December 31, 2008.

Submitted by the Audit Committee
of the Companys Board of Directors.

Members of the Audit Committee:

John J. Delucca (Chairman)

George F. Horner, III

Roger H. Kimmel



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The above Audit Committee Report does not constitute soliciting material, and shall not be deemed filed
or incorporated by reference into any other Company filing under the Securities Act of 1933 or the Securities Exchange Act of 1934, as amended, except to the extent that the Company specifically incorporates the Audit Committee Report by reference
therein.

Compensation Committee

The Compensation Committee of the Board of Directors determines the salaries and incentive compensation of the executive officers of the Company and provides recommendations for the salaries and incentive compensation
of the other employees of the Company. The Compensation Committee also reviews and acts on any recommendations of the Companys management for awards granted under the Endo Pharmaceuticals Holdings Inc. 2000 Stock Incentive Plan, the Endo
Pharmaceuticals Holdings Inc. 2004 Stock Incentive Plan and the Endo Pharmaceuticals Holdings Inc. 2007 Stock Incentive Plan. The current members of the Compensation Committee are Messrs. Delucca, Horner and Hyatt, each of whom is
independent in accordance with the criteria established by the SEC and NASDAQ. The Board has elected Mr. Hyatt as Chair of the Compensation Committee. Between January 1, 2007 and December 31, 2007, the Compensation
Committee met thirteen times. The Compensation Committee operates pursuant to a written charter adopted by the Board of Directors, which is available on the Companys website at www.endo.com, under Investors-Corporate
Governance. The charter describes the nature and scope of responsibilities of the Compensation Committee.

Compensation Committee
Interlocks and Insider Participation

None of the members of the Compensation Committee during fiscal 2007 or as of the date of
this Report is or has been an officer or employee of the Company and no executive officer of the Company served on the compensation committee or board of any company that employed any member of the Companys Compensation Committee or Board of
Directors.

Nominating & Governance Committee

On December 13, 2006, the Board of Directors chartered the Nominating & Governance Committee, which is comprised of independent directors.

The Nominating & Governance Committee of the Board of Directors identifies and recommends to the Board individuals qualified to serve as
directors of the Company, recommends to the Board directors to serve on committees of the Board and advises the Board with respect to matters of Board composition and procedures. The Nominating & Governance Committee also oversees the
Companys corporate governance.

The Nominating & Governance Committee will consider director candidates recommended by
stockholders. In considering candidates submitted by stockholders, the Nominating & Governance Committee will take into consideration the needs of the Board and the qualifications of the candidate. The Nominating & Governance
Committee may also take into consideration the number of shares held by the recommending stockholder and the length of time that such shares have been held. To have a candidate considered by the Nominating & Governance Committee, a
stockholder must submit the recommendation in writing and must include the following information:



| |  |  | The name of the stockholder and evidence of the persons ownership of Company stock, including the number of shares owned and the length of time of
ownership; and
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | The name of the candidate, the candidates resume or a listing of his or her qualifications to be a director of the Company and the persons consent to be
named as a director if selected by the Nominating & Governance Committee and nominated by the Board.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The
stockholder recommendation and information described above must be sent to the Secretary at Endo Pharmaceutical Holdings Inc., 100 Endo Boulevard, Chadds Ford, PA 19317, and must be received by the Secretary not less than 120 days prior to the
anniversary date of the Companys most recent annual meeting of shareholders.

Among the qualifications considered in the selection of
nominees, the Nominating & Governance Committee looks at the following attributes and criteria of nominees: experience, skills, expertise, and personal and professional integrity, character, business judgment, time availability in light of
other commitments, dedication, conflicts of interest and such other relevant factors that the Nominating & Governance Committee considers appropriate in the context of the needs of the Board of Directors. The Nominating &
Governance Committee identifies potential nominees by asking current directors and executive officers to notify the Nominating & Governance Committee if they become aware of persons meeting the criteria described above. The
Nominating & Governance Committee also, from time to time, may engage firms that specialize in identifying director candidates. As described above, the Nominating & Governance Committee will also consider candidates recommended by
stockholders.

Once a person has been identified by the Nominating & Governance Committee as a potential candidate, the Nominating
& Governance Committee may collect and review publicly available information regarding the person to assess whether the person should be considered further. If the Nominating & Governance Committee determines that the candidate warrants
further consideration, the Chairman or a member of the Nominating & Governance Committee contacts the person. Generally, if the person expresses a willingness to be considered and to serve on the Board, the Nominating & Governance
Committee requests information from the candidate, reviews the persons accomplishments and qualifications, including in light of any other candidates that the Nominating & Governance Committee might be considering, and conducts one or
more interviews with the candidate. Generally, Nominating & Governance Committee members conduct additional due diligence of the candidate. The Nominating & Governance Committees evaluation process does not vary based on
whether or not a candidate is recommended by a stockholder, although, as stated above, the Board may take into consideration the number of shares held by the recommending stockholder and the length of time that such shares have been held.

The current members of the Nominating & Governance Committee are Messrs. de Rosen, Kimmel and Hyatt. The Board has elected
Mr. Kimmel as Chair of the Nominating & Governance Committee. Between January 1, 2007 and December 31, 2007, the Nominating & Governance Committee met four times. The Board of Directors has determined that all of the
members of the Nominating & Governance Committee are independent in accordance with the criteria established by the SEC and NASDAQ. The Nominating & Governance Committee operates pursuant to a written charter adopted by
the Board of Directors, which is available on the Companys website at www.endo.com, under Investors-Corporate Governance.

Transactions Committee

On July 31, 2007, the Board of Directors formed a Transactions Committee to provide advice and
guidance to the Companys management in connection with the exploration of strategic acquisition and licensing opportunities as well as any overture for merger with the Company, or sale of the Company or like event. The current members of the
Transactions Committee are Roger Kimmel, Michel de Rosen and George Horner. Mr. Kimmel is the Chair of the Transactions Committee.



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|Item 11. | Executive Compensation
|-------- | ----------------------

Compensation Discussion and Analysis

Roles and Responsibilities of Compensation Committee

The primary purpose of the Compensation Committee is to conduct reviews of the Companys general executive compensation policies and strategies and
oversee and evaluate the Companys overall compensation structure and programs. The Compensation Committee confirms that total compensation paid to the chief executive officer, chief financial officer and those other individuals included in the
Summary Compensation Table set out under the heading Compensation of Executive Officers is reasonable and competitive. All of these individuals are referred to as the named executive officers. Direct responsibilities
of the Compensation Committee include, but are not limited to:



| |  |  | evaluating and approving goals and objectives relevant to compensation of the chief executive officer and other named executive officers, and evaluating the
performance of the executives in light of those goals and objectives;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | determining and recommending for approval by the Board of Directors the compensation level of the chief executive officer;
| | - |  | --------------------------------------------------------------------------------------------------------------------------



| |  |  | evaluating and approving compensation levels of the named executive officers (and certain other employees);
| | - |  | -----------------------------------------------------------------------------------------------------------



| |  |  | evaluating and approving all grants of equity-based compensation to the named executive officers (and certain other employees);
| | - |  | -------------------------------------------------------------------------------------------------------------------------------



| |  |  | recommending to the Board compensation policies for outside directors;
| | - |  | ----------------------------------------------------------------------



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| |  |  | reviewing performance-based and equity-based incentive plans for the chief executive officer, other named executive officers and certain other employees and
reviewing other benefit programs presented to the Compensation Committee by management; and
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | reviewing and approving the aggregate amount of dollars, in the case of the annual incentive compensation (IC), and stock options and restricted stock units, in the
case of the annual long-term incentive compensation, that is available to the Company each year (these aggregate amounts are then divided among the employees in the discretion of management based on each employees performance).
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Responsibilities of Endo Management

Endo management is required to provide reviews and recommendations for the Compensation Committees consideration, and to manage the Companys executive compensation programs, policies and governance. Direct
responsibilities in this regard include, but are not limited to:



| |  |  | providing an ongoing review of the effectiveness of the compensation programs for all employees, including competitiveness, and alignment with the Companys
objectives;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | recommending changes, if necessary to ensure achievement of all program objectives; and
| | - |  | ---------------------------------------------------------------------------------------



| |  |  | recommending pay levels, payout and/or awards for named executive officers and certain other employees other than the chief executive officer.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------

The Compensation Committee can exercise its discretion in modifying any recommended adjustments or awards to the named
executive officers.

Outside Consultants

Since June 2006, the Compensation Committee has retained the firm of Towers Perrin, an outside global human resources consulting firm, as its compensation consultant to assist in the continual development and evaluation of compensation
policies and the Compensation Committees determinations of compensation awards. Towers Perrin is asked to provide independent, third-party advice and expertise in executive compensation issues. Towers Perrin provides the Compensation Committee
with comparative market data and alternatives to consider when making compensation decisions and reviews the recommendations being made by the Companys management for executives other than the chief executive officer. The Compensation
Committee may retain other consultants and advisors from time to time. The Compensation Committee retains the ultimate responsibility for all compensation decisions.

The Companys Executive Compensation Program Philosophy

Overall Program Objectives

The Companys primary objective with respect to executive compensation is to design compensation programs that will align
executives compensation with the Companys overall business strategies and attract, motivate and retain highly qualified executives. The Compensation Committee believes that the most effective executive compensation program is one that is
designed to reward the achievement of specific annual, long-term and strategic goals of the Company, and which aligns executives interests with those of the shareholders by rewarding performance in meeting or exceeding established goals, with
the ultimate objective of improving shareholder value.



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Accordingly, the Company provides incentives to advance the interests of shareholders and deliver levels
of compensation that are commensurate with performance. Overall, the Company designs its compensation program to:



| |  |  | create a strong performance alignment with shareholders interests;
| | - |  | -------------------------------------------------------------------



| |  |  | support the corporate business strategy and business plan by clearly communicating what is expected of executives with respect to goals and results and by rewarding
achievement; and
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | recruit and retain executive talent.
| | - |  | ------------------------------------

The Company seeks to achieve these objectives through three key compensation elements:



| |  |  | a base salary;
| | - |  | --------------



| |  |  | a performance-based annual cash incentive (i.e., annual cash incentive compensation (IC)); and
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | annual (and, under certain circumstances, periodic) grants of long-term, equity-based compensation (i.e., a long-term incentive), which has historically been
comprised of stock options (and more recently restricted stock units) that are subject to time-based vesting requirements.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

In order to enhance the Compensation Committees ability to carry out its responsibilities effectively, as well as ensure that the Company maintains strong links between executive pay and performance, the Compensation Committee reviews
compensation information for each named executive officer which includes the following information:



| |  |  | the annual compensation and benefit values that are being offered to each executive;
| | - |  | ------------------------------------------------------------------------------------



| |  |  | the value of all outstanding equity awards; and
| | - |  | -----------------------------------------------



| |  |  | the value of all other compensation.
| | - |  | ------------------------------------

The Compensation Committee also meets with our chief executive officer and other senior management in connection with compensation matters and regularly meets in executive session with Towers Perrin but without management.

Competitive Considerations

In making
compensation decisions with respect to each element of compensation, the Compensation Committee considers the competitive market for executives and compensation levels provided by comparable companies. The Compensation Committee regularly reviews
the compensation practices at companies with which it competes for talent, including businesses engaged in activities similar to those of the Company, especially specialty pharmaceuticals. While we do not believe that it is appropriate to establish
compensation levels based primarily on benchmarking, we believe that information regarding pay practices at other companies is nevertheless useful in two respects. First, we recognize that our compensation practices must be competitive in the
marketplace. Second, independent marketplace information is one of the many factors that we consider in assessing the reasonableness of compensation.

The Compensation Committee believes that generally total executive compensation is targeted to fall between the median and the third quartile of compensation packages for executives in similar positions and with
similar responsibilities at similar companies of comparable size. The Compensation Committees choice of this target percentile reflects the Companys consideration for our shareholders interests in paying what is necessary, but not
significantly more than necessary, to achieve our corporate goals, while conserving cash and equity as much as practicable.



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We believe that, given the industry in which we operate and our compensation philosophy and objectives,
compensation falling between the median and the third quartile of similar companies is generally sufficient to retain our current executive officers and to hire new executive officers when and as required. In setting compensation for the named
executive officers, the Compensation Committee considers comparative market data requested from Towers Perrin, its compensation consultant. In gathering relevant competitive market compensation data, the Compensation Committee approved the use of a
sample of mid-sized specialty pharmaceutical companies, including high-growth industry companies with similar operations as Endo and mid-sized pharmaceutical companies that participate in Towers Perrins compensation database.

We refer to all of these sample companies as the Data Point Companies. The Committee believes that Endo competes with the Data Point
Companies for talent and for shareholder investment. The Data Point Companies create a range of comparative compensation values that are utilized by the Compensation Committee to confirm that salary levels and overall incentive opportunities
approved by the Compensation Committee are consistent with the Companys overall objectives. The current Data Point Companies are:

Abraxis
BioScience, Inc.

Alkermes, Inc.

Allergan Inc.

Barr Pharmaceuticals Inc.

Cephalon Inc.

DURECT Corp.

Forest Laboratories Inc.

King Pharmaceuticals Inc.

Medicines Co.

Medicis Pharmaceutical Corp.

MedImmune Inc.

MGI Pharma Inc.

Millennium Pharmaceuticals Inc.

Mylan Laboratories Inc.

Sciele Pharma Inc.

Sepracor Inc.

Watson Pharmaceuticals Inc.

From time to time, the Compensation Committee re-evaluates the Data Point Companies in light of the Companys size and business. Accordingly, the
Data Point Companies may change. The Compensation Committee does not attempt to set each compensation element for each executive within a particular range related to levels provided by the Data Point Companies. Instead, the Compensation Committee
uses market comparisons as one factor in making compensation decisions. Other factors considered when making individual executive compensation decisions include individual contribution and performance, reporting structure, complexity and importance
of role and responsibilities, leadership and growth potential.

Compensation Components

The three principal components of the Companys total compensation are: base salary, cash incentive compensation (IC) and long-term equity-based
incentive compensation (LTI). In allocating compensation among these elements, we believe that the majority of the compensation of our senior-most levels of managementthe levels of management having the greatest ability to influence the
Companys performanceshould be performance-based, while lower levels of management should receive a greater portion of their compensation in base salary.



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Under our compensation structure, the mix of base salary, cash incentive compensation and long-term
equity-based incentive compensation varies depending on each named executive officers level. Although the Company has no pre-established policy or target for the allocation between either cash and non-cash or short-term and long-term incentive
compensation, the following was the 2007 targeted mix (as well as 2007 actual mix) of these compensation vehicles for the named executive officers:



|                      |  |                 |         |                                  |   |                                  |  |                                                 |         |                                                 |   |           |  |   |        
|--------------------- |  | --------------- | ------- | -------------------------------- | - | -------------------------------- |  | ----------------------------------------------- | ------- | ----------------------------------------------- | - | --------- |  | - | -------
|                      |  | 2007 BaseSalary |         | 2007 IncentiveCompensationTarget |   | 2007 IncentiveCompensationActual |  | 2007 Long-TermEquityIncentiveCompensationTarget |         | 2007 Long-TermEquityIncentiveCompensationActual
|Peter A. Lankau (1)   |  | $               | 606,000 |                                  | $ | 363,600                          |  | $                                               | 300,000 |                                                 | $ | 3,150,000 |  | $ |       
|Charles A. Rowland    |  | $               | 450,000 |                                  | $ | 225,000                          |  | $                                               | 225,000 |                                                 | $ | 675,000   |  | $ | 675,000
|Nancy J. Wysenski (2) |  | $               | 143,365 |                                  | $ | 78,851                           |  | $                                               | 78,851  |                                                 | $ | 299,970   |  | $ | 450,000
|Caroline B. Manogue   |  | $               | 375,000 |                                  | $ | 187,500                          |  | $                                               | 187,500 |                                                 | $ | 562,500   |  | $ | 562,500
|David A.H. Lee (3)    |  | $               | 209,091 |                                  | $ | 104,546                          |  | $                                               | 94,091  |                                                 | $ | 313,637   |  | $ | 282,273
|Joyce N. LaViscount   |  | $               | 275,000 |                                  | $ | 82,500                           |  | $                                               | 82,500  |                                                 | $ | 165,000   |  | $ | 165,000



|(1) | Mr. Lankau announced his resignation on January 28, 2008, effective March 1, 2008. David P. Holveck joined the Company as its President & Chief Executive
Officer on April 1, 2008.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | Ms. Wysenski joined Endo in September 2007. Accordingly, her 2007 base salary and incentive compensation targets shown above are pro-rated. Her annual rate of pay for 2007 is
$450,000, and her 2007 long-term equity incentive compensation was not pro-rated. As described in more detail below under the section titled Employment and Change in Control Agreements; Severance Agreements, Ms. Wysenski, our Chief
Operating Officer, (i) was paid $100,000 in connection with her commencement of employment with the Company on September 7, 2007, which amount will be grossed up for tax purposes in fiscal 2008 and (ii) was granted 100,000 stock
options on such date.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | As described in more detail below under the section titled Employment and Change in Control Agreements; Severance Agreements, Dr. Lee, our Chief Scientific Officer,
is eligible for long-term equity incentive compensation equal to one-hundred-and-fifty percent (150%) of his 2007 salary for services rendered in 2007 (to be awarded in 2008). Prior to this year, Dr. Lee received long-term incentive
compensation by virtue of his being a member of Endo Pharma LLC (which is no longer affiliated with the Company, but which is an affiliate of Kelso & Company in which Dr. Lee has an interest), and, accordingly, he was not historically
eligible for long-term equity incentive compensation from the Company.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Base Salary

Purpose. The objective of base salary is to reflect job responsibilities, value to the Company and individual performance taking into
consideration market competitiveness. We seek to provide our executive officers with competitive annual base salaries in order to attract and retain them. The base salary component of our executive officer compensation program is not designed to
incentivize our near-term performance (as performance-based cash bonuses are designed to do), but rather to provide the baseline level of compensation to executive officers.



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Considerations. Salaries for the named executive officers are determined initially by each
individuals employment agreement, which are described under Employment Agreements below. These salaries and the amount of any increase over these salaries are determined by the Compensation Committee based on a variety of
factors, including:



| |  |  | the nature and responsibility of the position and, to the extent available, salary norms for persons in comparable positions at the Data Point Companies;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the expertise of the individual executive;
| | - |  | ------------------------------------------



| |  |  | the competitiveness of the market for the executives services;
| | - |  | ---------------------------------------------------------------



| |  |  | internal review of the executives compensation, both individually and relative to other named executive officers;
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | the recommendations of the chief executive officer (except in the case of the chief executive officers own compensation); and
| | - |  | ------------------------------------------------------------------------------------------------------------------------------



| |  |  | individual performance of the named executive officer, which includes:
| | - |  | ----------------------------------------------------------------------



| |  |  | achievement of individual annual goals and objectives, the risks and challenges involved, and the impact of the results;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | performance of day-to-day responsibilities;
| | - |  | -------------------------------------------



| |  |  | increases in competencies and skill development;
| | - |  | ------------------------------------------------



| |  |  | value of their contribution to function and company goal achievement; and
| | - |  | -------------------------------------------------------------------------



| |  |  | behaviors aligned with Endo core values.
| | - |  | ----------------------------------------

Base salaries are generally reviewed annually. In reviewing salaries, the Compensation Committee adjusts salaries from time to time to realign salaries with market levels, individual performance and incumbent experience. The Compensation
Committee also considers salaries relative to those of others within the Company and may, on occasion, make adjustments to salaries or other elements of total compensation, such as incentive compensation and long-term incentive opportunities, where
such an adjustment would correct a compensation imbalance, as the Compensation Committee deems appropriate.

Fiscal Year 2007 Decisions
Regarding Base Salary. In October 2007, as part of the Compensation Committees annual review of compensation, Towers Perrin provided the Compensation Committee with a market assessment of the competitive compensation for the
Companys executive officers. This assessment included reviewing the Data Point Companies and:



| |  |  | establishing a benchmark match for each of the positions;
| | - |  | ---------------------------------------------------------



| |  |  | gathering and analyzing competitive compensation from relevant labor markets; and
| | - |  | ---------------------------------------------------------------------------------



| |  |  | developing competitive market medians of compensation for the positions.
| | - |  | ------------------------------------------------------------------------

Based on the competitive market data referred to above, the Compensation Committee developed, with the assistance of Towers Perrin, market medians of
compensation for each of Endos compensation elements



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(base salary, target annual incentive compensation, and expected value of long-term incentive compensation) and then compared each of Endos executive
officers current compensation to the market median for each data sample. The data showed that Endos former chief executive officer, Peter A. Lankau, who announced his resignation effective March 1, 2008, was compensated below the
market competitive range for base salary but that the other executive officers are compensated within fifteen percent (15%) of the median of the market competitive range for base salary. The market data and the performance of each of
Endos executive officer are reviewed each year, and there is no guarantee that any of their compensation will be aligned with the market.

Therefore, the following changes to the base salary of the named executive officers occurred in early 2008. Effective March 1, 2008, based on each individuals performance, Ms. LaViscounts salary was increased to
$295,625, Dr. Lees salary was increased to $215,364, Ms. Manogues salary was increased to $390,000, Mr. Rowlands salary was increased to $468,000 and Ms. Wysenskis salary was increased to $468,000.
Mr. Lankau announced his resignation on January 28, 2008, effective March 1, 2008, and accordingly was not awarded any change to his 2008 base salary.

Performance-Based Annual Cash Incentive Compensation (IC)

Purpose. The
compensation program provides for an annual incentive that is performance linked. This incentive compensation, or IC, program is a short-term incentive plan that rewards achievement of annual goals and objectives. The objective of the program is to
compensate individuals based on the achievement of specific goals that are intended to correlate closely with shareholder value.

Considerations. The annual cash incentive compensation includes various incentive levels based on the named executive officers accountability and impact on Company operations, with target award opportunities established as
a percentage of base salary. Under the employment agreement for each named executive officer, a target IC bonus is established, which is determined based on all factors that the Compensation Committee deems relevant, including (but not limited to) a
review of the Data Point Companies compensation. In fiscal 2007, these targets ranged from 30% to 50% of base salary for the Companys named executive officers. The annual bonus process for our named executive officers involves two basic
steps:



| |  |  | At the outset of the fiscal year:
| | - |  | ---------------------------------

Set overall Company performance goals for the year; and



| |  |  | At the end of the fiscal year:
| | - |  | ------------------------------

Measure actual performance (individual and Company-wide) against the predetermined Company performance goals and individual performance measures to determine the appropriate award.

These two steps are further described below:

(1) Setting Company performance goals. Early in each fiscal year, the Compensation Committee, working with senior management sets performance goals for the Company. In fiscal 2007, the bonus determination for each named
executive officer was primarily based upon the Companys performance against these goals. The goals that were established for fiscal 2007 are discussed below under Fiscal Year 2007 Decisions Regarding Incentive Compensation.

In determining the extent to which the pre-set performance goals are met for a given period, the Compensation Committee exercises its
judgment whether to reflect or exclude the impact of changes in accounting principles and extraordinary, unusual or infrequently occurring events reported in the Companys public filings.



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(2) Measuring performance. After the end of the fiscal year, the Compensation Committee
reviews the Companys actual performance against each of the performance goals established at the outset of the year. The Compensation Committee assesses the Companys performance as well as each named executive officers performance
against the individual goals set at the outset of the year. This assessment allows bonus decisions to take into account each named executive officers personal performance and contribution during the year.

Discretion. Under the IC plan, the Compensation Committee has discretion, in appropriate circumstances (e.g., should the individuals
performance in any particular year be outstanding), to grant a lower or higher incentive payout versus target.

Fiscal Year 2007
Decisions Regarding Incentive Compensation. With respect to fiscal year 2007, the annual award for each of the named executive officers was based on the achievement of corporate goals as well as each executive officers individual
performance. At the beginning of fiscal 2007, the Compensation Committee established performance goals for fiscal 2007, which were divided into the following categories and were weighted as follows:

|                                                                                                                                                                                                                                                               |  |    
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ---
|                                                                                                                                                                                                                                                               | 
|     Financial Objectives, which included achieving certain total net sales and earnings per share targets,
as well as targets related to product development and launches and achieving specified net sales and demand targets by product                    |  | 40%
|                                                                                                                                                                                                                                                               | 
|     Portfolio Development, which included adding to the Companys current portfolio both through
acquisitions and licensing transactions, in each case aligned with the strategic direction of the business, as well as through internal product development |  | 40%
|                                                                                                                                                                                                                                                               | 
|     Organizational Advancement, which included appropriately enhancing the Companys personnel and
infrastructure with a focus on improvement of core business processes and enhancing systems and controls                                                  |  | 20%

The specific annual performance goals reflect the Companys confidential operating plan and
information, reflecting the Companys confidential planning process, and, accordingly, to disclose these goals publicly would cause significant competitive harm to the Company.

These performance goals are intended to be challenging and ambitious but also realistic enough to be reasonably attainable given a very concerted effort
on the part of the Companys named executive officers in consideration of conditions and trends. In the past three fiscal years the named executive officers achieved performance goals at target or slightly below target levels. For 2007, a 95%
incentive pool target was granted by the Compensation Committee (for both IC and long-term equity-based incentive).

The Compensation
Committee reviewed the Companys achievement of the financial and other objectives set forth above as well as each named executive officers contributions and awarded the named executive officers the bonus amounts set forth in the Summary
Compensation Table.

Specifically, each of the following named executive officers received incentive compensation for 2007 performance
equal to the following, expressed as a percentage of the IC targets set forth in their respective employment agreements, each in effect on December 31, 2007: Mr. Lankau, Chief Executive Officer82.5%; Ms. LaViscount, Chief
Accounting Officer100%; Dr. Lee, Chief Scientific Officer90%; Ms. Manogue, Chief Legal Officer100%; Mr. Rowland, Chief Financial Officer100%; and Ms. Wysenski, Chief Operating Officer 100%.
Mr. Lankau announced his resignation on January 28, 2008, effective March 1, 2008. These percentages reflected the Compensation Committees judgment as to the extent to which applicable targets were met.



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See also below under the heading Post-Termination Benefit that under employment agreements
each named executive officer will be entitled to cash incentive compensation as a percentage of salary.

Long-term Equity-Based
Incentive Compensation

Purpose. The long-term incentive program provides an annual award (and, under certain
circumstances, a periodic award) that is performance based. The objective of the program is to align compensation for named executive officers over a multi-year period directly with the interests of shareholders of the Company by motivating and
rewarding creation and preservation of long-term shareholder value. The level of long-term incentive (LTI) compensation is determined based on an evaluation of competitive factors in conjunction with total compensation provided to named executive
officers and the goals of the compensation program described above. Currently, long-term incentive awards are equity based.

Stock
Options. The Companys long-term incentive compensation has historically taken the form of stock option awards. Stock options (which have exercise prices equal to the closing price on the date of grant) reward named executive officers
only if the stock price increases.

The long-term incentive program calls for stock options to be granted with exercise prices of not less
than the closing price of the Companys common stock as quoted on the NASDAQ on the date of grant and generally to vest ratably over four years, based on continued employment. The Compensation Committee will not reduce the exercise price of
stock options (except in connection with adjustments to reflect recapitalizations, stock or extraordinary dividends, stock splits, mergers, spin-offs and similar events permitted by the relevant plan) without shareholder approval. New option grants
to named executive officers normally have a term of ten years.

Restricted Stock Units. Beginning with grants made in 2008 relating
to 2007 performance, the Compensation Committee determined to reduce the number of shares underlying stock option grants (determined using the Black-Scholes valuation method) and add a grant of time-based restricted stock units (RSUs) for a lesser
number of shares based on the closing price of our common stock on the NASDAQ on the date of grant. Each RSU represents the right to receive one (1) share of Company common stock as of the date of vesting. The Company believes that a
combination of stock options and RSUs will more closely equate the value of the benefit received by the recipient to the accounting expense of the benefit to the Company. The Company also believes that the resulting blend of options and RSUs will
more accurately reflect the pattern of equity-based awards that prevails in the Data Point Companies and in the external market generally. For 2008 grants, the targeted mix of options and RSUs for the named executive officers LTI was 75%
options and 25% RSUs. For all employees in the Company, the targeted mix for 2008 grants is as follows:



|                       |  |                                                  |  |                            |  |                          
|---------------------- |  | ------------------------------------------------ |  | -------------------------- |  | -------------------------
|Vehicle                |  | Named Executive Officers &Senior Vice Presidents |  | Vice Presidents &Directors |  | Managers & OtherEmployees
|Stock Options          |  | 75% of Total LTI                                 |  | 50% of Total LTI           |  | Not Offered              
|Restricted Stock Units |  | 25% of Total LTI                                 |  | 50% of Total LTI           |  | 100% of Total LTI        

Considerations. The Company believes that the most effective means to encourage
long-term performance by our named executive officers is to create an ownership culture. This philosophy is implemented



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through the granting of equity-based awards that vest based on continued employment. The long-term incentive program, which currently consists of equity
based awards, is designed to set up a future reward structure so that employees who have an impact on the Companys performance share in the results of that impact. The long-term incentive pool is established annually based on company
achievement of goals and objectives, and can vary significantly from year to year. All Company employees are eligible to receive long-term incentive, although long-term incentives are allocated most heavily to:



| |  |  | Reward consistently high performing individuals who we expect will drive the future value of the company;
| | - |  | ---------------------------------------------------------------------------------------------------------



| |  |  | Reward individuals at all levels who have high impact relative to the expectations of their role; and
| | - |  | -----------------------------------------------------------------------------------------------------



| |  |  | Retain individuals who have skills critical to the long-term success of the Company and who exemplify core value behavior.
| | - |  | --------------------------------------------------------------------------------------------------------------------------

Timing of Grants. Annual grants of stock options and RSUs to our named executive officers are made at a regularly scheduled meeting of the Board
of Directors held during the first quarter of each year, and the grant date is the date of that meeting. The Compensation Committee may also make occasional grants during the year to employees of the Company. These grants are typically associated
with promotions and hiring, and are typically made on the effective date of the promotion or the first day of work.

On September 6,
2007, upon the commencement of Ms. Wysenskis employment with the Company, she was granted 100,000 stock options. These stock options were issued under the Companys 2004 Stock Incentive Plan, and will vest ratably over a four-year
period, one-fourth per year on each of the first four anniversaries of the date of grant, provided Ms. Wysenski remains employed by the Company.

On January 25, 2008, the Board of Directors approved a one-time special grant of stock options to three of our executive officers in connection with the resignation of Mr. Lankau and the resulting increase
in responsibility for each of these individuals and in order to retain these individuals. Specifically, each of the following named executive officers received stock options on January 25, 2008: Ms. Manogue (50,000 stock options),
Mr. Rowland (75,000 stock options) and Ms. Wysenski (75,000 stock options). The grant price for all stock option grants is the closing price of our common stock as quoted on the NASDAQ on the date of grant. These stock options will vest
50% per year on January 25, 2009 and January 25, 2010, and upon termination of employment, these options will be treated in accordance with the 2007 Stock Incentive Plan; provided, however, that upon termination of any of these
executives employment with the Company (i) by the Company without Cause or (ii) by the executive officer for good reason (in each case as such terms are defined in the respective executives employment agreement),
all of these options including any previously unexercisable portions thereof shall become fully vested and exercisable as of the date of such termination of employment and shall remain exercisable for a period of one (1) year from and including
the date of termination of employment and shall terminate thereafter.

Periodic Review. The Compensation Committee intends to
review both the annual incentive compensation program and the long-term incentive program annually to confirm that their key elements continue to meet the objectives described above.

Fiscal Year 2007 Decisions Regarding Long-Term Equity-Based Incentive Program. In fiscal 2007, the Compensation Committee awarded long-term
compensation for named executive officers pursuant to the program described above resulting in the awards of stock options identified in the Summary Compensation Table, the Stock Option Awards Table and the Long-Term Incentive Performance Based
Awards Table.



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In determining the annual grants of long-term incentive to the named executive officers, the Compensation
Committee considered any pre-existing contractual requirements, market data on total compensation packages, the value of long-term incentive grants at the Data Point Companies, total shareholder return, share usage and shareholder dilution and,
except in the case of the award to the chief executive officer, the recommendations of the chief executive officer.

Taking into account
the above factors, each of the following named executive officers received long-term incentive compensation (consisting of stock options and RSUs) in the proportions described above in February 2008 for 2007 performance equal to the following,
expressed as a percentage of the targets set forth in their respective employment agreements, each as in effect on December 31, 2007: Ms. LaViscount, Chief Accounting Officer100%; Dr. Lee, Chief Scientific Officer90%;
Ms. Manogue, Chief Legal Officer100%; Mr. Rowland, Chief Financial Officer100%; and Ms. Wysenski, Chief Operating Officer- 100%. Mr. Lankau announced his resignation on January 28, 2008, effective
March 1, 2008, and, accordingly, did not receive long-term incentive compensation in 2008.

Benefits and Perquisites

The Companys current practice is to limit use of perquisites. In 2007, other than as described below, the only perquisites
provided to the named executive officers were financial planning services, use of a company car and term life insurance. Under the terms of her original employment agreement with the Company, the Company provided Ms. Manogue a rental house in
the Chadds Ford, Pennsylvania area. This perquisite was offered to Ms. Manogue to facilitate her move to Pennsylvania from New York City. The Compensation Committee agreed to continue this benefit through the term of the lease for this rental
property, which concluded in May 2007, after which time, this benefit terminated. In connection with Mr. Rowlands joining the Company as our chief financial officer in December 2006, the Company agreed to provide him with a relocation
allowance of up to $75,000 to cover documented and reasonable moving expenses that are incurred within twelve (12) months of December 6, 2006. An additional sum of $75,000 to cover any realtors fees incurred by Mr. Rowland in
connection with his relocation to the Chadds Ford, Pennsylvania area will also be paid by the Company. Mr. Rowland was also eligible for temporary living expense reimbursement, to be approved by the Company, for up to twelve (12) months
after December 6, 2006. All such sums must be repaid to the Company in the event Mr. Rowland voluntarily terminates his employment within eighteen (18) months of December 6, 2006. In connection with Ms. Wysenskis
joining the Company as our chief operating officer in September 2007, the Company agreed to provide her with a relocation allowance of up to $75,000 to cover documented and reasonable moving expenses that are incurred within twelve (12) months
of September 7, 2007. Ms. Wysenski is also eligible for temporary living expense reimbursement, to be approved by the Company, for up to twelve (12) months after September 7, 2007. Additionally, should her employment status
materially change involuntarily during her first twelve months of employment, she will be eligible for a one-time reverse relocation bonus of $75,000. All such sums must be repaid to the Company in the event Ms. Wysenski voluntarily terminates
her employment within eighteen (18) months of September 7, 2007. Finally, Ms. Wysenski was paid $100,000 in connection with her commencement of employment with the Company on September 7, 2007, which amount will be grossed up for
tax purposes in fiscal 2008.

Total Compensation

In making decisions with respect to any element of a named executive officers compensation, the Compensation Committee considers the total compensation that may be awarded to the officer, including salary,
annual IC bonus and long-term incentive compensation. In addition, in reviewing and approving employment agreements for named executive officers, the Compensation Committee considers the other benefits to which the officer is entitled by the
agreement, including compensation payable upon termination of the agreement under a variety of circumstances. The Compensation Committees goal is to award compensation that is competitive.



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Payments by Endo Pharma LLC to Carol A. Ammon

Endo Pharma LLC, a limited liability company that had at one point held a majority of our common stock (but that is no longer affiliated with us), and in
which affiliates of Kelso & Company have a controlling interest and in which a certain member of management has an interest, advised our Board of Directors that, in connection with its eventual winding up, it would make a special allocation
to Ms. Carol Ammon, our Chairman of the Board (until May 30, 2007) and former Chief Executive Officer, of approximately $22 million, with a portion of Ms. Ammons payment being satisfied by granting to her the remaining
unallocated Endo Pharma LLC stock options of approximately 0.8 million shares under the Endo Pharma LLC stock option plans. These 0.8 million options were granted by Endo Pharma LLC to Ms. Ammon in the fourth quarter of 2006 at an
exercise price of $2.42 per share. Endo Pharma LLC paid the remaining portion of the allocation, in an amount of $1.8 million, to Ms. Ammon in 2007.

Post-Termination Benefits

Retirement Benefits. In December 2007, the Board of
Directors approved the establishment, effective as of January 1, 2008, of two executive retirement programs: the 401(k) Restoration Plan and the Executive Deferred Compensation Plan, each of which are described below.

401(k) Restoration Plan

The purpose
of the 401(k) Restoration Plan (Parity Plan) is to provide eligible employees with the opportunity to defer a portion of their compensation on a tax-favored basis in parity with the tax benefit provided under the qualified 401(k) plan. The 401(k)
Parity Plan allows eligible employees whose compensation exceeds the Internal Revenue Code Section 401(a)(17) amount (or other criteria set by the Compensation Committee), including named executive officers, to defer eligible pay and receive company
matching contributions after such individuals compensation has exceeded the earnings maximum in the Companys existing qualified 401(k) plan. The amount in any individuals 401(k) Parity Plan account will be paid to such individual
at termination of employment. Actual 401(k) Parity Plan participation will begin when an executives total cash compensation exceeds the Internal Revenue Code earnings limit for the qualified 401(k) ($230,000 for 2008). Individuals who elect to
defer their eligible pay under the 401(k) Parity Plan will defer federal and state (to the extent allowed by state law) taxes until the account is paid to the individual.

Executive Deferred Compensation Plan

In December 2007, the Board of Directors approved the
establishment of the Executive Deferred Compensation Plan, which permits executives to elect to defer up to 100% of the portion of the following years long-term incentive compensation that is in the form of restricted stock units (RSUs). The
RSUs will vest while deferred. The 2008 grant of RSUs to executives will vest 50% in 2010 and 50% in 2012. It is anticipated that future grants will vest on the fourth anniversary of the grant date.

Deferral of the RSUs defers federal and state (as allowed under state laws) taxes on the compensation when the RSUs vest. The compensation is deferred
until the deferred RSUs are settled in stock. The RSUs may be deferred to the earlier of termination or to a certain date from two to ten years after January 1 of the year of the grant. The value of the compensation an executive receives upon
the stock delivery is based on the value of the Companys common stock on the date the deferral is delivered to the executive, and the executive will be responsible for the federal and state taxes at that time. To date, no current executive
officer has made an election to defer.

The Executive Deferred Compensation Plan also allows an executive to defer up to 50% of his or her
annual cash incentive compensation award. When an executive makes his or her irrevocable election to defer cash incentive compensation, he or she also elects the time at which to receive payment of the deferral and the form of the payment. An
individual may choose to defer the cash incentive compensation to a certain date from



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two to ten years after January 1 of the year of the grant or to termination of employment, whichever is earlier, and may choose to have the deferral
paid in a lump sum or two to ten installments payments.

Employment and Change in Control Agreements; Severance Agreements

For many years, the Company has followed the practice of entering into a written employment agreement with each of its named executive
officers. On December 19, 2007, the Company entered into amended and restated employment agreements with each of our named executive officers. On March 12, 2008 the Company announced that David P. Holveck had been named the Companys
President and Chief Executive Officer, with effect from April 1, 2008. The Company entered into an employment agreement with Mr. Holveck as of April 1, 2008.

The purpose of these agreements is to aid retention and recruitment and to encourage continued attention and dedication to assigned duties during periods
of uncertainty in connection with a possible change in control transaction.

With the exception of Mr. Holvecks employment
agreement, each of these employment agreements has a rolling twenty-four month employment period commencing each day after January 1, 2008 and ending on the twenty-four month anniversary of such day (the Employment Period), unless
either the Company or the named executive officer elects to terminate his or her Employment Agreement. Each Employment Agreement sets forth the annual salary of the respective named executive officer, which is, in each case, subject to annual
reviews, at the discretion of the Compensation Committee.

Each named executive officer will be paid cash incentive compensation in an
amount equal to a set percentage of his or her annual salary for each fiscal year (or such lesser or greater (not to exceed two hundred percent of the salary for such fiscal year) amount as is recommended in good faith and approved by the
Compensation Committee) if the Company achieves certain performance targets set by the Compensation Committee for such fiscal year. The target cash incentive target for each named executive officer as contained in their respective employment
agreement is set forth below:



|                        |  |                                   
|----------------------- |  | ----------------------------------
|Named Executive Officer |  | Target Incentive Compensation (IC)
|                        | 
|Peter A. Lankau*        |  | 60% of his annual salary          
|                        | 
|Nancy J. Wysenski       |  | 55% of her annual salary          
|                        | 
|Charles A. Rowland      |  | 50% of his annual salary          
|                        | 
|Caroline B. Manogue     |  | 50% of her annual salary          
|                        | 
|David A.H. Lee          |  | 50% of his annual salary          
|                        | 
|Joyce N. LaViscount     |  | 30% of her annual salary          

| | 
| | 

| | * | Mr. Lankau announced his resignation on January 28, 2008, effective March 1, 2008. On March 12, 2008 the Company announced that David P. Holveck had been named
the Companys President and Chief Executive Officer, with effect from April 1, 2008.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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Each named executive officer is eligible to earn as additional compensation for the services to be
rendered pursuant to his or her employment agreement, long-term equity incentives (LTI) in an amount approved by the Compensation Committee.

Each of the named executive officers is eligible to earn as additional compensation the long-term equity incentives set forth in the following table equal to a set percentage of his or her annual salary for each fiscal year (or such lesser
or greater percent of the salary for such fiscal year as is as is recommended in good faith by the chief executive officer and approved by the Compensation Committee):



|                        |  |                                              
|----------------------- |  | ---------------------------------------------
|Named Executive Officer |  | Target Long-Term Incentive Compensation (LTI)
|                        | 
|Peter A. Lankau         |  | **                                           
|                        | 
|Nancy J. Wysenski       |  | 200% of her annual salary                    
|                        | 
|Charles A. Rowland      |  | 150% of his annual salary                    
|                        | 
|Caroline B. Manogue     |  | 150% of her annual salary                    
|                        | 
|David A.H. Lee          |  | 150% of his annual salary                    
|                        | 
|Joyce N. LaViscount     |  | 60% of her annual salary                     

| | 
| | 

| | ** | Mr. Lankaus employment agreement provides that he shall be eligible to earn long-term compensation for services rendered in 2007 equal in value to $3,150,000 (or such
lesser or greater amount as is approved by the Compensation Committee). However, Mr. Lankau announced his resignation on January 28, 2008, effective March 1, 2008, and accordingly, did not receive long-term compensation for services
rendered in 2007.
| | -- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

If any named executive officer terminates his or her employment agreement for good reason or if the
Company terminates him or her without cause, the Company will (i) pay a lump sum equal to two times (one times for Ms. LaViscount) his or her then current salary and target incentive compensation for the fiscal year in which the
termination is effective and (ii) continue to provide such named executive officer with medical and life insurance benefits for twenty-four (24) months (twelve (12) months for Ms. LaViscount). If a named executive officer is
terminated other than for cause within twenty-four (24) months of a change in control, then such named executive officer (including Ms. LaViscount) will be entitled to receive (x) a lump sum payment equal to two times the sum of
(1) such named executive officers then current salary plus (2) the higher of (a) such named executive officers target incentive compensation for the fiscal year during which the termination is effective or (b) such
named executive officers incentive compensation for the fiscal year immediately preceding the year in which the termination is effective, plus (y) medical and life insurance benefits for a period equal to twenty-four (24) months
after the date on which the termination is effective. Each named executive officers employment agreement contains a non-compete provision. Finally, Dr. Lees Employment Agreement is based on a work week of not more on average than
twenty (20) hours per week.



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Deductibility Cap on Executive Compensation and Company Policy on Parachute Payments

The federal income tax laws limit the deductibility of certain compensation paid to the Chief Executive Officers and the four most highly compensated
executives required to be reported in the Summary Compensation Table (the covered employees) in excess of the statutory maximum of $1 million per covered employee. The Compensation Committee considers the applicable rules regarding
deductibility when making awards, but reserves the right to make nondeductible payments when it deems appropriate. Each of the named executive officers employment agreement provides that, if any of the payments or benefits received or to be
received by the executive (including any payment or benefits received in connection with a change of control or the executives termination of employment) will be subject to the excise tax under Section 4999 of the Internal Revenue Code
for excess parachute payments, then the Company will pay to the executive an additional amount (for excise tax gross-up) such that the net amount retained by the executive, after deduction of any excise tax on and any federal, state and local income
and employment taxes and after taking into account the phase out of itemized deductions and personal exemptions attributable to this payment, shall be equal to the total payments the executive would have otherwise received. An excess parachute
payment is generally a change in control payment in excess of one times the average of the officers taxable W-2 income for the five years prior to the change in control (base amount), and generally only results if the change in control payment
exceeds 2.99 times the base amount. Excess parachute payments, including any excise tax gross-up payments, are non-deductible to the Company under Section 280G of the Internal Revenue Code.

Recovery of Compensation

Although
the Company does not have a formal policy relating to repayment of performance and other incentive based awards in the event of a restatement of its financial results, if the Companys financial results were to be materially restated, the
Compensation Committee would review the circumstances surrounding the restatement and determine whether to seek repayment of any such awards determined by the Compensation Committee to have been inappropriately received by the executive.

Peter A. Lankau Resignation; Appointment of David P. Holveck

On January 28, Peter A. Lankau announced his resignation as President and Chief Executive Officer of the Company effective March 1, 2008. He has also resigned from the Companys Board of Directors
effective January 28, 2008. In connection with Mr. Lankaus resignation, the Company and Mr. Lankau entered into a separation agreement that provides Mr. Lankau with the payments and benefits which he would have been
entitled to receive under his existing employment agreement had he been terminated by the Company, as well as accelerated vesting of 6,379 stock options originally granted on August 11, 2004 and 125,000 stock options originally granted on
April 27, 2005. The remaining 256,250 stock options were unvested on March 1, 2008 and lapsed in accordance with their terms.

On March 12, 2008 the Company announced that David P. Holveck had been named the Companys President and Chief Executive Officer, with effect from April 1, 2008. Mr. Holveck was appointed to the
Companys Board of Directors on March 25, 2008 to fill the vacancy created by Mr. Lankaus resignation.

In connection
with Mr. Holvecks appointment as President and Chief Executive Officer, the Company entered into an executive employment agreement with Mr. Holveck, effective as of April 1, 2008. The initial term of Mr. Holvecks
agreement is three years and renews automatically for successive one-year periods unless 120 days notice of non-renewal is given by either party.

Under the terms of his employment agreement, Mr. Holveck is entitled to a base salary of $800,000 and an annual cash performance bonus with a target of 80% of salary and a maximum bonus of 200% of his base
salary, as recommended and approved by the Compensation Committee, if the Company and Mr. Holveck achieve certain performance targets set by the Compensation Committee. Mr. Holveck received an initial grant of 46,088 restricted stock units
on April 1, 2008 with approximately 86% vesting on the third anniversary of grant and approximately 14% vesting on the fourth anniversary of grant, in each case provided that Mr. Holveck is still employed by the Company on the applicable
vesting dates. Mr. Holveck also received an initial grant of 188,632 stock options on April 1, 2008, vesting ratably over 4 years, based on continued employment by Mr. Holveck on the applicable vesting dates. The vesting of these
equity awards accelerates in the event of Mr. Holvecks death or disability or termination without cause or for good reason (as such terms are defined in Mr. Holvecks employment agreement).



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Mr. Holveck is entitled to those other employee benefits, perquisites, reimbursement of expenses and vacation as are available to other senior
executives of the Company.

Mr. Holvecks employment agreement provides that on termination without cause or for good reason,
including during the 24-month period following a change in control, Mr. Holveck will be entitled to a prorated bonus for year of termination (based on actual results), severance in an amount equal to two times the sum of his base salary and
target bonus, and continuation of health and life insurance benefits for two years following termination. Receipt of this severance is conditioned on Mr. Holvecks release of claims against the Company. Payments upon death or disability
include a prorated bonus for the year of termination (based on actual results), and, in the event of disability, 24 months of salary continuation offset by disability benefits.

Mr. Holvecks employment agreement also provides that Mr. Holveck will receive an additional payment to reimburse him for any excise tax
imposed pursuant to section 4999 of the Internal Revenue Code, together with amounts for any additional taxes incurred by reason of such payment.

Mr. Holvecks employment agreement also obligates Mr. Holveck not to solicit employees of the Company to cease employment for 24 months and not to compete with the Company for 18 months following termination of employment,
and to adhere to covenants relating to non-disparagement, and cooperation in any investigations and litigation.

Compensation Committee
Report on Executive Compensation

The Compensation Committee reviewed and discussed with the Companys management the
Compensation Discussion and Analysis included herein. In reliance on the review and discussions referred to above, the Compensation Committee recommended to the Board of Directors that the Compensation Discussion and Analysis be
included in the Companys Annual Report on Form 10-K for the fiscal year ended December 31, 2007 and the Companys Proxy Statement to be filed in connection with the Companys 2008 Annual Meeting of Stockholders, each of which
will be filed with the Securities and Exchange Commission.

Submitted by the Compensation Committee of the Companys Board of
Directors.

Members of the Compensation Committee:

Michael Hyatt (Chairman)

John J. Delucca

George F. Horner, III



50



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##### Table of Contents

Compensation of Executive Officers

Summary Compensation Table

The following summary compensation table sets forth, the cash and
non-cash compensation paid to or earned by our Chief Executive Officer, Chief Financial Officer and the other four most highly compensated executive officers of the Company (collectively, the Named Executive Officers) for the fiscal year
ending December 31, 2006 and December 31, 2007.



|                                                                |  |      |  |            |         |           |   |                    |  |                                            |           |                             |   |           |  |   |           |  |   |           |    
|--------------------------------------------------------------- |  | ---- |  | ---------- | ------- | --------- | - | ------------------ |  | ------------------------------------------ | --------- | --------------------------- | - | --------- |  | - | --------- |  | - | --------- | ---
|Name & Principal Position                                       |  | Year |  | Salary ($) |         | Bonus ($) |   | OptionAwards($)(1) |  | Non-EquityIncentive PlanCompensation($)(2) |           | All OtherCompensation($)(3) |   | Total ($) | 
|Peter A. Lankau (4)                                             |  | 2007 |  | $          | 606,000 |           | $ |                   |  | $                                          | 2,954,930 |                             | $ | 300,000   |  | $ | 121,902   |  | $ | 3,982,832 |    
|President & Chief Executive Officer                             |  | 2006 |  | $          | 519,500 |           | $ |                   |  | $                                          | 2,583,200 |                             | $ | 220,788   |  | $ | 3,059,086 |  | $ | 6,382,574 | (5)
|Nancy J. Wysenski (6) (7)                                       |  | 2007 |  | $          | 143,365 |           | $ | 144,899            |  | $                                          | 119,097   |                             | $ | 78,851    |  | $ | 23,797    |  | $ | 510,009   |    
|Chief Operating Officer                                         |  |      |  |            |         |           |   |                    |  |                                            |           |                             |   |           |  |   |           |  |   |           |    
|Charles A. Rowland, Jr. (8) (9)                                 |  | 2007 |  | $          | 450,000 |           | $ |                   |  | $                                          | 443,247   |                             | $ | 225,000   |  | $ | 133,705   |  | $ | 1,251,952 |    
|Executive Vice President, Chief Financial Officer and Treasurer |  | 2006 |  | $          | 32,596  |           | $ | 225,000            |  | $                                          | 30,359    |                             | $ |          |  | $ | 105       |  | $ | 288,060   |    
|Caroline B. Manogue                                             |  | 2007 |  | $          | 375,000 |           | $ |                   |  | $                                          | 782,941   |                             | $ | 187,500   |  | $ | 154,198   |  | $ | 1,499,639 |    
|Executive Vice President, Chief Legal Officer and Secretary     |  | 2006 |  | $          | 365,468 |           | $ |                   |  | $                                          | 676,919   |                             | $ | 168,115   |  | $ | 6,152,731 |  | $ | 7,363,233 | (5)
|Joyce N. LaViscount                                             |  | 2007 |  | $          | 275,000 |           | $ |                   |  | $                                          | 336,064   |                             | $ | 82,500    |  | $ | 37,472    |  | $ | 731,036   |    
|Vice President, Chief Accounting Officer                        |  | 2006 |  | $          | 224,480 |           | $ |                   |  | $                                          | 152,924   |                             | $ | 74,750    |  | $ | 12,145    |  | $ | 464,299   |    
|David A.H. Lee, M.D., Ph.D. (10)                                |  | 2007 |  | $          | 209,091 |           | $ |                   |  | $                                          | 0         |                             | $ | 94,091    |  | $ | 52,699    |  | $ | 355,881   |    
|Chief Scientific Officer                                        |  | 2006 |  | $          | 404,431 |           | $ |                   |  | $                                          | 0         |                             | $ | 153,688   |  | $ | 64,241    |  | $ | 622,360   |    



|(1) | The amounts shown in this column represent the compensation expense for each executives awards under FAS 123(R), including a portion of the value of option awards made in
prior years, since expense is recognized ratably over a four-year requisite service period (but disregarding estimates of forfeitures for service-based vesting). See notes to our audited financial statements included in our 2007 and 2006 Annual
Report on Form 10-K for the assumptions we used in valuing and expensing these option awards in accordance with FAS 123(R).
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | The amounts shown in this column represent cash amounts earned pursuant to the Companys incentive compensation plan with respect to 2007 and 2006 performance, respectively.
These amounts were awarded by the Committee on February 21, 2008 and February 21, 2007, respectively.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | The amounts shown in this column for 2007 include the items summarized in the table below:
|--- | ------------------------------------------------------------------------------------------



|                            |  |      |  |                                       |        |                                                       |   |                          |  |                      |       |          |   |        |  |   |       
|--------------------------- |  | ---- |  | ------------------------------------- | ------ | ----------------------------------------------------- | - | ------------------------ |  | -------------------- | ----- | -------- | - | ------ |  | - | ------
|Name                        |  | Year |  | Perquisites& OtherPersonalBenefits(a) |        | RegistrantContributionsto DefinedContributionPlans(b) |   | LifeInsurancePremiums(c) |  | TaxReimbursements(d) |       | Other(e)
|Peter A. Lankau             |  | 2007 |  | $                                     | 36,325 |                                                       | $ | 13,500                   |  | $                    | 1,090 |          | $ | 25,031 |  | $ | 45,956
|Nancy J. Wysenski(f)        |  | 2007 |  | $                                     | 10,310 |                                                       | $ | 6,750                    |  | $                    |      |          | $ | 6,737  |  | $ |      
|Charles A. Rowland, Jr.     |  | 2007 |  | $                                     | 72,700 |                                                       | $ | 13,500                   |  | $                    |      |          | $ | 47,505 |  | $ |      
|Caroline B. Manogue         |  | 2007 |  | $                                     | 56,780 |                                                       | $ | 13,500                   |  | $                    | 260   |          | $ | 37,272 |  | $ | 46,386
|Joyce N. LaViscount         |  | 2007 |  | $                                     | 10,784 |                                                       | $ | 13,500                   |  | $                    | 690   |          | $ | 7,498  |  | $ | 5,000 
|David A.H. Lee, M.D., Ph.D. |  | 2007 |  | $                                     | 22,305 |                                                       | $ | 12,546                   |  | $                    | 1,980 |          | $ | 15,868 |  | $ |      



| | (a) | Mr. Lankau received $10,473 for financial planning services, $23,329 for car allowance and related costs and $2,523 for spousal travel allowance.
Ms. Wysenski received $8,280 for relocation allowance and $2,030 for car allowance and related costs. Mr. Rowland received $46,120 for relocation allowance, $15,464 for financial planning services and $11,116 for car allowance and related
costs. Ms. Manogue
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | received $32,619 for housing allowance, $14,650 for car allowance and related costs and $9,511 for financial planning services. Ms. LaViscount received
$10,784 for car allowance and related costs. Dr. Lee received $9,322 for financial planning services and $12,983 for car allowance and related costs.
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (b) | Represents the employers matching contribution to the Companys Savings and Investment (401(k)) Plan.
| | --- | ------------------------------------------------------------------------------------------------------



| | (c) | Represents annual premiums paid by the Company for executive term life insurance policies. Such policies have also been purchased as of January 1, 2008 for Ms. Wysenski
and Mr. Rowland.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (d) | The amounts shown in this column represent the reimbursement of taxes associated with perquisites and other benefits.
| | --- | ---------------------------------------------------------------------------------------------------------------------



| | (e) | The amounts shown in this column represent payment for accrued but unused vacation days. All Company employees that maintained a balance of accrued but unused vacation days as of
December 31, 2006, were eligible for such payment.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (f) | The Company expects to provide an additional payment in 2008 to offset taxes associated with Ms. Wysenskis signing bonus.
| | --- | --------------------------------------------------------------------------------------------------------------------------



|(4) | Mr. Lankau resigned as President and Chief Executive Officer of the Company effective March 1, 2008. He also resigned from the Companys board of directors effective
January 28, 2008.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(5) | 2006 amounts shown include cash awards made by Endo Pharma LLC in April 2006 to each of Mr. Lankau and Ms. Manogue in the amount of $3 million and $6 million respectively, in
recognition of their significant past contributions to Endos success. Endo Pharma LLC is a limited liability company that is no longer affiliated with the Company, but had historically held significant portions of our common stock, in which
affiliates of Kelso & Company and certain current and former members of management have an interest.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(6) | Ms. Wysenski joined Endo in September 2007. Her annual rate of pay for 2007 is $450,000.
|--- | ----------------------------------------------------------------------------------------



|(7) | Ms. Wysenski received a $100,000 signing bonus in September 2007 upon joining the Company plus a $44,899 additional bonus to recognize her contributions in 2007.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------



|(8) | Mr. Rowland was paid a cash award of $225,000 for 2006 in connection with his commencement of employment with the Company: this payment was in lieu of an award under the
Incentive Compensation Plan in 2007 and was paid on March 13, 2007.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(9) | Mr. Rowland joined Endo in December 2006. His annual rate of pay for 2006 was $450,000.
|--- | ---------------------------------------------------------------------------------------



|(10) | Dr. Lees salary was reduced to $209,091 based on his part-time employment agreement beginning in 2007.
|---- | -------------------------------------------------------------------------------------------------------

The employment agreements, short-term and long-term incentive compensation plans and awards, explanation of amount of salary and bonus in proportion to
total compensation, and other elements of the Summary Compensation Table are discussed at length in the Compensation Discussion and Analysis above.



52



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##### Table of Contents

2007 Grants of Plan-Based Awards

The following table summarizes grants of plan-based awards made to named executive officers during the fiscal year ended December 31, 2007:



|                            |  |              |  |                                                                    |   |                                                                  |   |                                             |  |                                              |           |  |         |  |   |       |  |            |  | 
|--------------------------- |  | ------------ |  | ------------------------------------------------------------------ | - | ---------------------------------------------------------------- | - | ------------------------------------------- |  | -------------------------------------------- | --------- |  | ------- |  | - | ----- |  | ---------- |  | 
|Name                        |  | GrantDate(1) |  | Estimated Possible Payouts UnderNon-Equity Incentive PlanAwards(2) |   | All OtherOptionAwards:Number ofSecuritiesUnderlyingOptions(#)(3) |   | Exerciseor BasePrice ofOptionAwards($ / Sh) |  | GrantDate FairValue ofStock &OptionAwards(4)
|                            |  | Threshold($) |  | Target($)                                                          |   | Maximum($)                                                       |   |                                             | 
|Peter A. Lankau(5)          |  |              |  | $                                                                  | 0 |                                                                  | $ | 363,600                                     |  | $                                            | 1,212,000 |  |         |  |   |       |  |           
|21-Feb-07                   |  |              |  |                                                                    |   |                                                                  |   |                                             |  |                                              |           |  | 175,000 |  | $ | 30.55 |  | $2,661,978
|Nancy J. Wysenski (6)       |  |              |  | $                                                                  | 0 |                                                                  | $ | 78,851                                      |  | $                                            | 286,730   |  |         |  |   |       |  |           
|06-Sep-07                   |  |              |  |                                                                    |   |                                                                  |   |                                             |  |                                              |           |  | 100,000 |  | $ | 32.09 |  | $1,500,010
|Charles A. Rowland, Jr.(7)  |  |              |  | $                                                                  | 0 |                                                                  | $ | 225,000                                     |  | $                                            | 900,000   |  |         |  |   |       |  |           
|Caroline B. Manogue         |  |              |  | $                                                                  | 0 |                                                                  | $ | 187,500                                     |  | $                                            | 750,000   |  |         |  |   |       |  |           
|21-Feb-07                   |  |              |  |                                                                    |   |                                                                  |   |                                             |  |                                              |           |  | 42,279  |  | $ | 30.55 |  | $643,119  
|David A.H. Lee, M.D., Ph.D. |  |              |  | $                                                                  | 0 |                                                                  | $ | 104,546                                     |  | $                                            | 418,182   |  |         |  |   |       |  |           
|Joyce N. LaViscount         |  |              |  | $                                                                  | 0 |                                                                  | $ | 82,500                                      |  | $                                            | 550,000   |  |         |  |   |       |  |           
|21-Feb-07                   |  |              |  |                                                                    |   |                                                                  |   |                                             |  |                                              |           |  | 12,402  |  | $ | 30.55 |  | $188,651  



|(1) | The grant date of all awards is the date of the Board of Directors action in which such award is approved.
|--- | ----------------------------------------------------------------------------------------------------------



|(2) | The amounts shown in these columns represent the range of Incentive Compensation Plan payouts targeted for 2007 performance as described in the section titled
Performance-Based Annual Cash Incentive Compensation (IC) in the Compensation Discussion and Analysis above. There is no threshold for this award. The bonus payment for 2007 performance has been made according to the metrics
described, and is shown in the Summary Compensation Table in the column titled Non-Equity Incentive Plan Compensation.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | These options were granted in 2007 based on the Companys 2006 long-term incentive compensation payout. The 2007 equity incentive payout was made in February 2008 and is shown
in more detail below:
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|                            |  |                                                                                            |  |                                                   |       |                                                                          |       |                                            |   |        
|--------------------------- |  | ------------------------------------------------------------------------------------------ |  | ------------------------------------------------- | ----- | ------------------------------------------------------------------------ | ----- | ------------------------------------------ | - | -------
|Name                        |  | 2007 Long-TermEquity IncentiveCompensation:Number of SecuritiesUnderlying StockOptions (#) |  | Exercise or BasePrice of OptionAwards ($ / Sh)(a) |       | 2007 Long-TermEquityIncentiveCompensation:RestrictedStock Units (RSU)(#) |       | GrantDate FairValue ofRSU &OptionAwards(b)
|Peter A. Lankau             |  |                                                                                           |  |                                                   |      |                                                                          |      |                                            |   |       
|Nancy J. Wysenski           |  | 32,577                                                                                     |  | $                                                 | 25.19 |                                                                          | 4,466 |                                            | $ | 450,000
|Charles A. Rowland, Jr.     |  | 48,866                                                                                     |  | $                                                 | 25.19 |                                                                          | 6,699 |                                            | $ | 675,000
|Caroline B. Manogue         |  | 40,722                                                                                     |  | $                                                 | 25.19 |                                                                          | 5,583 |                                            | $ | 562,500
|Joyce N. LaViscount         |  | 7,963                                                                                      |  | $                                                 | 25.19 |                                                                          | 3,275 |                                            | $ | 165,000
|David A.H. Lee, M.D., Ph.D. |  | 20,435                                                                                     |  | $                                                 | 25.19 |                                                                          | 2,801 |                                            | $ | 282,273



| | (a) | The exercise price is equal to the closing price on the date of grant, which was February 21, 2008.
| | --- | ---------------------------------------------------------------------------------------------------



| | (b) | The amounts shown in this column include the fair value under FAS 123(R) of the 2007 option awards on the date of grant determined using the Black-Scholes valuation
model. Although the fair value of executive stock option grants listed above has been determined in accordance with the applicable
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | accounting standards, that value may not be indicative of the fair value observed in a willing buyer/willing seller market transaction.
| | ---------------------------------------------------------------------------------------------------------------------------------------



| |  | On January 25, 2008, the Board of Directors approved a one-time special grant of stock options to three of our named executive officers in connection with the resignation of
Mr. Lankau and the resulting increase in responsibility for each of these individuals. Specifically, each of the following named executive officers received stock options on January 25, 2008: Ms. Manogue (50,000 stock options),
Mr. Rowland (75,000 stock options) and Ms. Wysenski (75,000 stock options). The exercise price for these stock option is the closing price of a share as quoted on the NASDAQ on the date of grant. These stock options will vest 50% per
year on January 25, 2009 and January 25, 2010, and upon termination of employment, these options will be treated in accordance with the 2007 Stock Incentive Plan; provided, however, that upon termination of any of these executives
employment with the Company (i) by the Company without Cause or (ii) by the executive officer for good reason (in each case as such terms are defined in the respective executives employment agreement), all of these
options including any previously unexercisable portions thereof shall become fully vested and exercisable as of the date of such termination of employment and shall remain exercisable for a period of one (1) year from and including the date of
termination of employment and shall terminate thereafter.
| |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | The amounts shown in this column represent the fair value under FAS 123(R) of awards granted in 2007 valued on the date of grant (even if not yet vested) determined using the
Black-Scholes valuation model. Although the fair value of executive stock option grants listed above has been determined in accordance with the applicable accounting standards, that value may not be indicative of the fair value observed in a willing
buyer/willing seller market transaction.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(5) | Mr. Lankau resigned as President and CEO of the Company effective March 1, 2008.
|--- | --------------------------------------------------------------------------------



|(6) | As described in more detail under the section titled Compensation Discussion and AnalysisEmployment and Change in Control Agreements; Severance Agreements,
Ms. Wysenski, our Chief Operating Officer, received 100,000 stock options in connection with the commencement of her employment with the Company on September 6, 2007.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(7) | As described in more detail under the section titled Compensation Discussion and AnalysisEmployment and Change in Control Agreements; Severance Agreements,
Mr. Rowland, our Chief Financial Officer, was paid $225,000 in connection with his commencement of employment with the Company on December 6, 2006; this payment was in lieu of an award under the incentive compensation plan for 2006
performance and was paid on March 13, 2007. Also on December 6, 2006, Mr. Rowland was granted (i) 100,000 stock options and (ii) in lieu of a 2006 option year grant (to have been granted in 2007), additional stock options
valued at $250,000, with all such options valued with reference to the closing market price on December 6, 2006. Mr. Rowlands 2007 equity and non-equity incentive plan targets are discussed in more detail under the section titled
Compensation Discussion and AnalysisEmployment and Change in Control Agreements; Severance Agreements.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

See
the Compensation Discussion and Analysis above regarding the material terms, determining amounts payable, vesting schedule and other material conditions of these grants.



54



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Outstanding Equity Awards at December 31, 2007

The following table summarizes the number of securities underlying outstanding plan awards for the named executive officers during the year ended
December 31, 2007:



|                            |  |                                                                |  |                                                                      |     |  |                         |       |                      |            
|--------------------------- |  | -------------------------------------------------------------- |  | -------------------------------------------------------------------- | --- |  | ----------------------- | ----- | -------------------- | -----------
|                            |  | Option Awards                                                 
|Name                        |  | Number ofSecuritiesUnderlyingUnexercisedOptions Exercisable(#) |  | Number ofSecuritiesUnderlyingUnexercisedOptions Unexercisable(#) (1) |     |  | OptionExercisePrice ($) |       | OptionExpirationDate
|Peter A. Lankau             |  |                                                               |  | 175,000                                                              | (2) |  | $                       | 30.55 |                      | 21-Feb-2017
|                            |  | 62,500                                                         |  | 187,500                                                              | (2) |  | $                       | 28.61 |                      | 14-Feb-2016
|                            |  | 125,000                                                        |  | 125,000                                                              | (3) |  | $                       | 20.22 |                      | 27-Apr-2015
|                            |  | 19,138                                                         |  | 6,379                                                                | (3) |  | $                       | 16.47 |                      | 11-Aug-2014
|                            |  | 300,000                                                        |  |                                                                     |     |  | $                       | 15.24 |                      | 05-Aug-2013
|                            |  | 89,999                                                         |  |                                                                     |     |  | $                       | 9.17  |                      | 19-Sep-2012
|Nancy J. Wysenski           |  |                                                               |  | 100,000                                                              |     |  | $                       | 32.09 |                      | 6-Sep-2017 
|Charles A. Rowland, Jr.     |  | 29,088                                                         |  | 87,263                                                               |     |  | $                       | 28.27 |                      | 06-Dec-2016
|Caroline B. Manogue         |  |                                                               |  | 42,279                                                               |     |  | $                       | 30.55 |                      | 21-Feb-2017
|                            |  | 32,500                                                         |  | 97,500                                                               |     |  | $                       | 28.61 |                      | 14-Feb-2016
|                            |  | 15,441                                                         |  | 5,147                                                                |     |  | $                       | 16.47 |                      | 11-Aug-2014
|                            |  | 70,000                                                         |  | 0                                                                    |     |  | $                       | 15.24 |                      | 05-Aug-2013
|Joyce N. LaViscount         |  |                                                               |  | 12,402                                                               |     |  | $                       | 30.55 |                      | 21-Feb-2017
|                            |  | 12,500                                                         |  | 37,500                                                               |     |  | $                       | 32.99 |                      | 10-Aug-2016
|                            |  | 3,025                                                          |  | 9,072                                                                |     |  | $                       | 28.61 |                      | 14-Feb-2016
|                            |  | 1,347                                                          |  | 448                                                                  |     |  | $                       | 16.47 |                      | 11-Aug-2014
|                            |  | 3,859                                                          |  | 1,286                                                                |     |  | $                       | 25.38 |                      | 12-Apr-2014
|David A.H. Lee, M.D., Ph.D. |  |                                                               |  |                                                                     |     |  |                         |      |                      |           



|(1) | The vesting dates of each option grant is listed in the table below by expiration date:
|--- | ---------------------------------------------------------------------------------------



|                |  |                          |  |                 |  |                          
|--------------- |  | ------------------------ |  | --------------- |  | -------------------------
|Expiration Date |  | Vesting Date             |  | Expiration Date |  | Vesting Date             
|                |  |                          | 
|6-Sep-2017      |  | 25% on September 6, 2008 |  | 27-Apr-2015     |  | 25% on April 27, 2006    
|                |  |                          | 
|                |  | 25% on September 6, 2009 |  |                 |  | 25% on April 27, 2007    
|                |  |                          | 
|                |  | 25% on September 6, 2010 |  |                 |  | 25% on April 27, 2008    
|                |  |                          | 
|                |  | 25% on September 6, 2011 |  |                 |  | 25% on April 27, 2009    
|                |  |                          | 
|21-Feb-2017     |  | 25% on February 21, 2008 |  | 11-Aug-2014     |  | 25% on August 11, 2005   
|                |  |                          | 
|                |  | 25% on February 21, 2009 |  |                 |  | 25% on August 11, 2006   
|                |  |                          | 
|                |  | 25% on February 21, 2010 |  |                 |  | 25% on August 11, 2007   
|                |  |                          | 
|                |  | 25% on February 21, 2011 |  |                 |  | 25% on August 11, 2008   
|                |  |                          | 
|6-Dec-2016      |  | 25% on December 6, 2007  |  | 12-Apr-2014     |  | 25% on April 12, 2005    
|                |  |                          | 
|                |  | 25% on December 6, 2008  |  |                 |  | 25% on April 12, 2006    
|                |  |                          | 
|                |  | 25% on December 6, 2009  |  |                 |  | 25% on April 12, 2007    
|                |  |                          | 
|                |  | 25% on December 6, 2010  |  |                 |  | 25% on April 12, 2008    
|                |  |                          | 
|10-Aug-2016     |  | 25% on August 10, 2007   |  | 05-Aug-2013     |  | 25% on August 5, 2004    
|                |  |                          | 
|                |  | 25% on August 10, 2008   |  |                 |  | 25% on August 5, 2005    
|                |  |                          | 
|                |  | 25% on August 10, 2009   |  |                 |  | 25% on August 5, 2006    
|                |  |                          | 
|                |  | 25% on August 10, 2010   |  |                 |  | 25% on August 5, 2007    
|                |  |                          | 
|14-Feb-2016     |  | 25% on February 14, 2007 |  | 19-Sep-2012     |  | 25% on September 19, 2003
|                |  |                          | 
|                |  | 25% on February 14, 2008 |  |                 |  | 25% on September 19, 2004
|                |  |                          | 
|                |  | 25% on February 14, 2009 |  |                 |  | 25% on September 19, 2005
|                |  |                          | 
|                |  | 25% on February 14, 2010 |  |                 |  | 25% on September 19, 2006



|(2) | 300,000 of these options were forfeited in connection with Mr. Lankaus separation from the Company on March 1, 2008
|--- | --------------------------------------------------------------------------------------------------------------------



|(3) | Pursuant to the terms of Mr. Lankaus Separation Agreement dated January 28, 2008, the vesting of these options was accelerated effective March 1, 2008.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------



55



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Options Exercises in 2007

The following table summarizes the stock option exercises by the named executive officers during the fiscal year ended December 31, 2007:



|                            |                                          |               |                               |   |          
|--------------------------- | ---------------------------------------- | ------------- | ----------------------------- | - | ---------
|Name                        |                                          | Option Awards
|                            | Number of SharesAcquired on Exercise (#) |               | Value Realized onExercise ($)
|Peter A. Lankau             |                                          |              |                               | $ |         
|Nancy J. Wysenski           |                                          |              |                               | $ |         
|Charles A. Rowland, Jr.     |                                          |              |                               | $ |         
|Caroline B. Manogue         |                                          | 59,660        |                               | $ | 1,528,752
|Joyce N. LaViscount         |                                          |              |                               | $ |         
|David A.H. Lee, M.D., Ph.D. |                                          |              |                               | $ |         

Potential Payments Upon Termination or Change in Control

As discussed and described in the Compensation Discussion and Analysis under the heading Post-Termination Benefits, on
December 19, 2007 the Company entered into amended and restated employment agreements with each of the named executive officers, effective December 19, 2007.



56



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The following tables show the potential payments upon termination or change of control to the named
executive officers, determined pursuant to amended and restated employment agreements executed and effective December 19, 2007 as if such event(s) took place on December 31, 2007.



|                                                                                   |  |                                               |  |       |           |               |   |                  |  |                                                            |         |                                                 |   |           |  |   |          
|---------------------------------------------------------------------------------- |  | --------------------------------------------- |  | ----- | --------- | ------------- | - | ---------------- |  | ---------------------------------------------------------- | ------- | ----------------------------------------------- | - | --------- |  | - | ---------
|                                                                                   |  | Terminationfor Cause,Resignation orRetirement |  | Death |           | Disability(2) |   | Change ofControl |  | TerminationWithout Cause(TWOC) orQuit for GoodReason(QFGR) |         | TWOC orQFGRWithin 24MonthsAfterChange ofControl
|Executive Peter A. Lankau(1) Two Times Base Salary Payable in Lump Sum            |  |                                              |  |       |          |               |   |                 |  |                                                            |        |                                                 | $ | 1,212,000 |  | $ | 1,212,000
|Two Times Target Incentive Compensation                                            |  |                                              |  |       |          |               |   |                 |  |                                                            |        |                                                 | $ | 727,200   |  |   |         
|Two Times Greater of Target Incentive Comp or Last Years Incentive Comp           |  |                                              |  |       |          |               |   |                 |  |                                                            |        |                                                 |   |          |  | $ | 727,200  
|24 Months Medical and Life Insurance Benefits                                      |  |                                              |  |       |          |               |   |                 |  |                                                            |        |                                                 | $ | 23,833    |  | $ | 23,833   
|Excess of 24 Months Base Salary Over Disability Insurance Benefits                 |  |                                              |  |       |          |               | $ | 924,000          |  |                                                            |        |                                                 |   |          |  |   |         
|Acceleration and Continuation of Equity Awards (in the money value at 12/31/07)(3) |  |                                              |  | $     | 871,316   |               |   |                 |  | $                                                          | 871,316 |                                                 |   |          |  |   |         
|Value of Term Life Insurance(4)                                                    |  |                                               |  | $     | 1,000,000 |               |   |                  |  |                                                            |         |                                                 |   |           |  |   |          
|Change of Control Excise Tax Gross-up(5)                                           |  |                                              |  |       |           |               |   |                  |  |                                                            |         |                                                 |   |           |  |   |          
|                                                                                   |  | Terminationfor Cause,Resignation orRetirement |  | Death |           | Disability(2) |   | Change ofControl |  | TWOCor QFGR                                                |         | TWOC orQFGRWithin 24MonthsAfterChange ofControl
|Executive Nancy J. Wysenski Two Times Base Salary Payable in Lump Sum             |  |                                              |  |       |          |               |   |                 |  |                                                            |        |                                                 | $ | 900,000   |  | $ | 900,000  
|Two Times Target Incentive Compensation                                            |  |                                              |  |       |          |               |   |                 |  |                                                            |        |                                                 | $ | 495,000   |  |   |         
|Two Times Greater of Target Incentive Comp or Last Years Incentive Comp           |  |                                              |  |       |          |               |   |                 |  |                                                            |        |                                                 |   |          |  | $ | 495,000  
|24 Months Medical and Life Insurance Benefits                                      |  |                                              |  |       |          |               |   |                 |  |                                                            |        |                                                 | $ | 39,126    |  | $ | 39,126   
|Excess of 24 Months Base Salary Over Disability Insurance Benefits                 |  |                                              |  |       |          |               | $ | 612,000          |  |                                                            |        |                                                 |   |          |  |   |         
|Acceleration and Continuation of Equity Awards (in the money value at 12/31/07)(3) |  |                                              |  |       |          |               |   |                 |  |                                                            |        |                                                 |   |          |  |   |         
|Value of Term Life Insurance(4)                                                    |  |                                               |  |       |          |               |   |                  |  |                                                            |         |                                                 |   |           |  |   |          
|Change of Control Excise Tax Gross-up(5)                                           |  |                                              |  |       |           |               |   |                  |  |                                                            |         |                                                 |   |           |  |   |          



57



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|                                                                                   |  |                                               |  |       |           |               |   |                 |  |             |        |                                                 |   |         |  |   |        
|---------------------------------------------------------------------------------- |  | --------------------------------------------- |  | ----- | --------- | ------------- | - | --------------- |  | ----------- | ------ | ----------------------------------------------- | - | ------- |  | - | -------
|                                                                                   |  | Terminationfor Cause,Resignation orRetirement |  | Death |           | Disability(2) |   | ChangeofControl |  | TWOCor QFGR |        | TWOC orQFGRWithin 24MonthsAfterChange ofControl
|Executive Charles A. Rowland, Jr. Two Times Base Salary Payable in Lump Sum       |  |                                              |  |       |          |               |   |                |  |             |       |                                                 | $ | 900,000 |  | $ | 900,000
|Two Times Target Incentive Compensation                                            |  |                                              |  |       |          |               |   |                |  |             |       |                                                 | $ | 450,000 |  |   |       
|Two Times Greater of Target Incentive Comp or Last Years Incentive Comp           |  |                                              |  |       |          |               |   |                |  |             |       |                                                 |   |        |  | $ | 450,000
|24 Months Medical and Life Insurance Benefits                                      |  |                                              |  |       |          |               |   |                |  |             |       |                                                 | $ | 39,126  |  | $ | 39,126 
|Excess of 24 Months Base Salary Over Disability Insurance Benefits                 |  |                                              |  |       |          |               | $ | 612,000         |  |             |       |                                                 |   |        |  |   |       
|Acceleration and Continuation of Equity Awards (in the money value at 12/31/07)(3) |  |                                              |  |       |          |               |   |                |  |             |       |                                                 |   |        |  |   |       
|Value of Term Life Insurance(4)                                                    |  |                                               |  |       |          |               |   |                 |  |             |        |                                                 |   |         |  |   |        
|Change of Control Excise Tax Gross-up(5)                                           |  |                                              |  |       |           |               |   |                 |  |             |        |                                                 |   |         |  | $ | 465,537
|                                                                                   |  | Terminationfor Cause,Resignation orRetirement |  | Death |           | Disability(2) |   | ChangeofControl |  | TWOCor QFGR |        | TWOC orQFGRWithin 24MonthsAfterChange ofControl
|Executive Caroline B. Manogue Two Times Base Salary Payable in Lump Sum           |  |                                              |  |       |           |               |   |                |  |             |       |                                                 | $ | 750,000 |  | $ | 750,000
|Two Times Target Incentive Compensation                                            |  |                                              |  |       |           |               |   |                |  |             |       |                                                 | $ | 375,000 |  |   |       
|Two Times Greater of Target Incentive Comp or Last Years Incentive Comp           |  |                                              |  |       |           |               |   |                |  |             |       |                                                 |   |        |  | $ | 375,000
|24 Months Medical and Life Insurance Benefits                                      |  |                                              |  |       |           |               |   |                |  |             |       |                                                 | $ | 38,005  |  | $ | 38,005 
|Excess of 24 Months Base Salary Over Disability Insurance Benefits                 |  |                                              |  |       |           |               | $ | 462,000         |  |             |       |                                                 |   |        |  |   |       
|Acceleration and Continuation of Equity Awards (in the money value at 12/31/07)(3) |  |                                              |  | $     | 52,499    |               |   |                |  | $           | 52,499 |                                                 |   |        |  |   |       
|Value of Term Life Insurance(4)                                                    |  |                                               |  | $     | 1,000,000 |               |   |                 |  |             |        |                                                 |   |         |  |   |        
|Change of Control Excise Tax Gross-up(5)                                           |  |                                              |  |       |           |               |   |                 |  |             |        |                                                 |   |         |  |   |        



58



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|                                                                                   |  |                                              |  |       |           |               |   |                 |  |             |       |                                                 |   |         |  |   |        
|---------------------------------------------------------------------------------- |  | -------------------------------------------- |  | ----- | --------- | ------------- | - | --------------- |  | ----------- | ----- | ----------------------------------------------- | - | ------- |  | - | -------
|                                                                                   |  | Terminationfor Cause,ResignationorRetirement |  | Death |           | Disability(2) |   | ChangeofControl |  | TWOCor QFGR |       | TWOC orQFGRWithin 24MonthsAfterChange ofControl
|Executive Joyce N. LaViscount Two Times Base Salary Payable in Lump Sum           |  |                                             |  |       |           |               |   |                |  |             |      |                                                 | $ | 275,000 |  | $ | 550,000
|One Times Target Incentive Compensation                                            |  |                                             |  |       |           |               |   |                |  |             |      |                                                 | $ | 82,500  |  |   |       
|Two Times Greater of Target Incentive Comp or Last Years Incentive Comp           |  |                                             |  |       |           |               |   |                |  |             |      |                                                 |   |        |  | $ | 165,000
|12 and 24 Months Medical and Life Insurance Benefits(6)                            |  |                                             |  |       |           |               |   |                |  |             |      |                                                 | $ | 19,563  |  | $ | 39,126 
|Excess of 12 Months Base Salary Over Disability Insurance Benefits                 |  |                                             |  |       |           |               | $ | 131,000         |  |             |      |                                                 |   |        |  |   |       
|Acceleration and Continuation of Equity Awards (in the money value at 12/31/07)(3) |  |                                             |  | $     | 6,229     |               |   |                |  | $           | 6,229 |                                                 |   |        |  |   |       
|Value of Term Life Insurance(4)                                                    |  |                                              |  | $     | 1,000,000 |               |   |                 |  |             |       |                                                 |   |         |  |   |        
|Change of Control Excise Tax Gross-up(5)                                           |  |                                              |  |       |           |               |   |                 |  |             |       |                                                 |   |         |  | $ | 276,675
|                                                                                   |  | Terminationfor Cause,ResignationorRetirement |  | Death |           | Disability(2) |   | ChangeofControl |  | TWOCor QFGR |       | TWOC orQFGRWithin 24MonthsAfterChange ofControl
|Executive David A.H. Lee, M.D., Ph.D. Two Times Base Salary Payable in Lump Sum   |  |                                             |  |       |           |               |   |                |  |             |      |                                                 | $ | 418,182 |  | $ | 418,182
|Two Times Target Incentive Compensation                                            |  |                                             |  |       |           |               |   |                |  |             |      |                                                 | $ | 209,091 |  |   |       
|Two Times Greater of Target Incentive Comp or Last Years Incentive Comp           |  |                                             |  |       |           |               |   |                |  |             |      |                                                 |   |        |  | $ | 209,091
|24 Months Medical and Life Insurance Benefits(2)                                   |  |                                             |  |       |           |               |   |                |  |             |      |                                                 | $ | 27,799  |  | $ | 27,799 
|Excess of 24 Months Base Salary Over Disability Insurance Benefits                 |  |                                             |  |       |           |               | $ | 167,273         |  |             |      |                                                 |   |        |  |   |       
|Acceleration and Continuation of Equity Awards (in the money value at 12/31/07)(3) |  |                                             |  |       |          |               |   |                |  |             |      |                                                 |   |        |  |   |       
|Value of Term Life Insurance(4)                                                    |  |                                              |  | $     | 1,000,000 |               |   |                 |  |             |       |                                                 |   |         |  |   |        
|Change of Control Excise Tax Gross-up(5)                                           |  |                                              |  |       |           |               |   |                 |  |             |       |                                                 |   |         |  |   |        



|(1) | Mr. Lankau resigned as President and Chief Executive Officer of the Company effective March 1, 2008. He also resigned from the Companys board of directors effective
January 28, 2008. The actual payments and benefits provided to Mr. Lankau in 2008 are detailed in Endos Current Report on Form 8-K filed on January 30, 2008.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(2) | Under the Endo Pharmaceuticals Holdings Inc. 2000, 2004 and 2007 Stock Incentive Plans, on disability all outstanding options, stock appreciation rights and all
other outstanding awards granted to a participant will continue to vest in accordance with the terms of the applicable agreements. The participant shall be entitled to exercise each such option or stock appreciation right and to make any payment,
give any notice or to
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



59



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| | satisfy other condition under each such other award, in each case, for a period of one (1) year from and including the later of (i) the date such
entire award becomes vested or exercisable and (ii) the date of termination of employment or retirement, and thereafter such awards or parts thereof shall be canceled. Notwithstanding the foregoing, the Compensation Committee of the Board of
Directors may in its sole discretion provide for a longer or shorter period for exercise of an option or stock appreciation right or may permit a participant to continue vesting under an option, stock appreciation right or restricted stock award or
to make any payment, give any notice or to satisfy other condition under any other award.
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | Upon termination without cause or quitting for good reason, as defined in the Stock Incentive Plans, the portions of outstanding exercisable options granted to participants shall
remain exercisable for a period of one year from termination of employment and shall terminate thereafter. Upon change of control, awards not previously exercisable and vested will become fully exercisable and vested.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | Our named executive officers are covered by term life insurance policies, the premiums for which are reimbursed by the Company. The premiums for these term life insurance policies
are listed above in the All Other Compensation table. The amounts included above represent the death benefits that would be received from the insurance provider under these life insurance policies. Term life insurance policies have also
been purchased as of January 1, 2008 for Ms. Wysenski and Mr. Rowland with coverage in the amount of $1,000,000 each.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(5) | Under the terms of the Amended and Restated Employment Agreements with each of our named executive officers, should any of the named executive officers become entitled to the change
of control payments detailed above (Total Payments), the Company will pay to the named executive officer, an additional amount (the Gross-Up Payment) such that the net amount retained by the named executive officer, after
deduction of any excise tax on excess parachute payments under section 4999 of the Internal Revenue Code (Excise Tax) on the Total Payments and any federal, state and local income and employment taxes and Excise Tax upon the Gross-Up
Payment, and after taking into account the phase out of itemized deductions and personal exemptions attributable to the Gross-Up Payment, shall be equal to the Total Payments.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(6) | As described in more detail above under the section titled Compensation Discussion and AnalysisEmployment and Change in Control Agreements; Severance Agreements,
if Ms. LaViscount terminates her employment agreement for good reason or if the Company terminates her without cause, the Company will continue to provide Ms. LaViscount with medical and life insurance benefits for a period equal to twelve
(12) months after the date on which the termination is effective. If Ms. LaViscount is terminated other than for cause within twelve (12) months of a change in control, then she will be entitled to receive benefits for a period equal
to twenty-four (24) months after the date on which the termination is effective.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2007 Compensation of Directors



|                               |  |                              |           |                       |   |                       |  |           |         |  |   |          
|------------------------------ |  | ---------------------------- | --------- | --------------------- | - | --------------------- |  | --------- | ------- |  | - | ---------
|Name                           |  | FeesEarned orPaid inCash ($) |           | StockAwards ($)(1)(2) |   | OptionAwards($)(1)(2) |  | Total ($)
|Roger H. Kimmel                |  | $                            | 155,750   |                       | $ | 27,147                |  | $         | 118,397 |  | $ | 301,294  
|Carol A. Ammon(3)              |  | $                            | 1,831,857 |                       | $ |                      |  | $         |        |  | $ | 1,831,857
|John J. Delucca                |  | $                            | 93,750    |                       | $ | 27,147                |  | $         | 56,415  |  | $ | 177,312  
|Michel de Rosen                |  | $                            | 72,750    |                       | $ | 27,147                |  | $         | 58,285  |  | $ | 158,182  
|George F. Horner III           |  | $                            | 86,250    |                       | $ | 27,147                |  | $         | 58,112  |  | $ | 171,509  
|Michael Hyatt                  |  | $                            | 81,750    |                       | $ | 27,147                |  | $         | 118,397 |  | $ | 227,294  
|Clive A. Meanwell, M.D., Ph.D. |  | $                            | 54,250    |                       | $ | 27,147                |  | $         | 118,397 |  | $ | 199,794  





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|(1) | The amounts shown in these columns represent the 2007 compensation expense for each directors stock-based awards under FAS 123(R), including a portion of the value of awards
made in prior years, since expense is recognized ratably over the four-year requisite service period (but disregarding forfeitures). See notes to our audited financial statements included in our 2007 and 2006 Annual Report on Form 10-K for the
assumptions we used in valuing and expensing these awards in accordance with FAS 123(R). The grant date fair value of each option and stock award granted in 2007, computed in accordance with FAS 123(R), is as follows:
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|                               |  |                |  |                                            |        |                                         |   |       
|------------------------------ |  | -------------- |  | ------------------------------------------ | ------ | --------------------------------------- | - | ------
|Name                           |  | Grant Date     |  | Fair Value on GrantDate of RestrictedStock |        | Fair Value onGrantDate of Stock Options
|Roger H. Kimmel                |  | March 12, 2007 |  | $                                          | 67,498 |                                         | $ | 67,507
|Carol A. Ammon                 |  |               |  |                                            |       |                                         |   |      
|John J. Delucca                |  | March 12, 2007 |  | $                                          | 67,498 |                                         | $ | 67,507
|Michel de Rosen                |  | March 12, 2007 |  | $                                          | 67,498 |                                         | $ | 67,507
|George F. Horner III           |  | March 12, 2007 |  | $                                          | 67,498 |                                         | $ | 67,507
|Michael Hyatt                  |  | March 12, 2007 |  | $                                          | 67,498 |                                         | $ | 67,507
|Clive A. Meanwell, M.D., Ph.D. |  | March 12, 2007 |  | $                                          | 67,498 |                                         | $ | 67,507



|(2) | The following table summarizes the number of stock options and restricted stock outstanding and exercisable at December 31, 2007, for each Director in 2007:
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------



|                               |  |                                     |  |                                     |  |                                    |  |                               |  |                           |        
|------------------------------ |  | ----------------------------------- |  | ----------------------------------- |  | ---------------------------------- |  | ----------------------------- |  | ------------------------- | -------
|Name                           |  | OptionsOutstanding atFiscal YearEnd |  | OptionsExercisable atFiscal YearEnd |  | SharesOutstanding atFiscal YearEnd |  | SharesVested atFiscal YearEnd |  | Value atFiscal YearEnd(a)
|Roger H. Kimmel                |  | 38,308                              |  | 18,741                              |  | 2,262                              |  |                              |  | $                         | 227,509
|Carol A. Ammon                 |  |                                    |  |                                    |  |                                   |  |                              |  |                           |       
|John J. Delucca                |  | 14,567                              |  | 2,500                               |  | 2,262                              |  |                              |  | $                         | 60,328 
|Michel de Rosen                |  | 14,567                              |  | 2,500                               |  | 2,262                              |  |                              |  | $                         | 60,328 
|George F. Horner III           |  | 14,567                              |  | 2,500                               |  | 2,262                              |  |                              |  | $                         | 60,328 
|Michael Hyatt                  |  | 54,567                              |  | 35,000                              |  | 2,262                              |  |                              |  | $                         | 523,328
|Clive A. Meanwell, M.D., Ph.D. |  | 39,567                              |  | 20,000                              |  | 2,262                              |  |                              |  | $                         | 247,028



| | (a) | Based upon the closing price on December 31, 2007 of $26.67. Includes all outstanding options as of December 31, 2007, for which the exercise price is equal to or less
than $26.67 per share.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | During 2006, Endo Pharma LLC (a limited liability company that is no longer affiliated with the Company, but had historically held significant portions of our common stock, in which
affiliates of Kelso & Company and certain current and former members of management have an interest) informed us that, in connection with its eventual winding-up, it would make a special allocation to Ms. Carol Ammon, our former
Chairman of the Board and former Chief Executive Officer, of approximately $22 million. The majority of the special allocation was paid in 2006, via the grant of 809,893 Endo Pharma LLC options. These stock options were granted pursuant to the Endo
Pharma LLC 1997 Stock Option Plan and, accordingly, were exercisable solely into shares of Company common stock that were held by Endo Pharma LLC (and not the Company). As a result, the exercise of these options did not result in the issuance of
additional shares of Company common stock and did not dilute the ownership of our other public stockholders. The remaining $1.8 million of the $22 million special allocation was paid to Ms. Ammon during 2007.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Annual Cash Retainer Fees. For fiscal year 2007, each non-employee director who was not affiliated with the Company (a Non-Affiliated
Director) received $7,500 cash per fiscal quarter of service. In addition,



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any Non-Affiliated Director who serves as the Chair of the Audit Committee receives an additional fee of $10,000 cash per year, and any Non-Affiliated
Director who serves as the Chair of the Compensation Committee, the Nominating & Governance Committee or the Transactions Committee receives an additional fee of $5,000 cash per year.

Meeting Fees. For fiscal year 2007, Non-Affiliated Directors also received a fee of $2,250 cash for attending each Board meeting and $1,000 cash
for attending each committee meeting on which such individual serves.

Stock-based Awards. Effective February 21, 2007, the
Non-Affiliate Directors received the stock compensation described below:



| |  |  | Each Non-Affiliated Director receives an annual stock award equal in value to $135,000, 50% of which is restricted stock units and 50% of which is options. The
number of securities actually awarded to each director is calculated using the Black-Scholes valuation methodology.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The Compensation Committee annually reviews current market data and, if appropriate, recommends to the Board of Directors any necessary adjustment to the expected
value of the annual stock award to directors.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | All restricted stock units vest ratably over two years (50% on the first anniversary of the grant date and the remaining 50% on the second anniversary of the grant
date). Stock option awards vest ratably over a four-year period (25% on each of the first four years after the date of grant).
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The annual stock award grant date is March 12 each year (or the next business day) and the exercise price of the securities granted is the closing price on the
day of grant.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------

On March 12, 2008, Non-Affiliated Directors each received:



| |  |  | 6,764 stock options with an exercise price of $24.63 (and a per option Black-Scholes value of $9.97), which vest ratably over a four-year period (25% on each of
March 12, 2009, March 12, 2010, March 12, 2011 and March 12, 2012); and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | 2,741 shares of restricted stock valued at $24.63 per share (the closing price on the day of grant), which vest ratably over two years (50% on each of
March 12, 2009 and March 12, 2010).
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Directors Stock Election Plan; Directors Deferred Compensation
Plan. Pursuant to the Endo Pharmaceuticals Directors Stock Election Plan, on December 16, 2007, Mr. Kimmel elected to receive 100% of his 2008 cash retainer fees in Endo common stock. Pursuant to the same plan, on December 27,
2007, Mr. de Rosen elected receive 50% of his 2008 cash retainer fees in Endo common stock. Accordingly, at the time that Messrs. Kimmel and de Rosens cash retainer fees are otherwise payable, the number of shares of Endo common stock are
fixed and are reported as an acquisition of securities. Under the Endo Pharmaceuticals Deferred Compensation Plan, also on December 16, 2007, Mr. Kimmel elected to defer receipt of all of these shares. Mr. Kimmel has also elected to
defer receipt of 50% of his annual grant of RSUs, the maximum permitted under the Deferred Compensation Plan.



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|Item 12. | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters
|-------- | ----------------------------------------------------------------------------------------------

Security Ownership of Certain Beneficial Owners and Management. The following table sets forth, as of April 15, 2008, the name, address and
holdings of each person, including any group as defined in Section 13(d)(3) of the Exchange Act, known by Endo to be the beneficial owner of more than 5% of common stock. Footnote (a) below provides a brief
explanation of what is meant by the term beneficial ownership. The following table also sets forth, as of April 15, 2008, the number of shares of common stock beneficially owned by each of the Companys current directors and
the chief executive officer, the chief financial officer and the other four most highly compensated executive officers of the Company as of April 15, 2008. The following table also sets forth, as of April 15, 2008, the number of shares of
common stock beneficially owned by all current directors and executive officers of the Company as a group.



|                                                                                                           |  |                                                    |  |                       |  
|---------------------------------------------------------------------------------------------------------- |  | -------------------------------------------------- |  | --------------------- | -
|Name of Beneficial Owner                                                                                   |  | Number ofShares ofCommon StockBeneficiallyOwned(a) |  | Percentage ofClass(a) |  
|Directors and Executive Officers:                                                                          |  |                                                    |  |                       |  
|John J. Delucca(b)                                                                                         |  | 26,334                                             |  | *                     |  
|Michel de Rosen(c)                                                                                         |  | 26,491                                             |  | *                     |  
|George F. Horner, III(d)                                                                                   |  | 26,334                                             |  | *                     |  
|Michael Hyatt(e)                                                                                           |  | 312,084                                            |  | *                     |  
|Roger H. Kimmel(f)                                                                                         |  | 217,198                                            |  | *                     |  
|Clive A. Meanwell, M.D., Ph.D.(g)                                                                          |  | 51,334                                             |  | *                     |  
|David P. Holveck(h)(i)                                                                                     |  | 234,720                                            |  | *                     |  
|David A. H. Lee, M.D., Ph.D.(h)(j)                                                                         |  | 208,990                                            |  | *                     |  
|Caroline B. Manogue(h)(k)                                                                                  |  | 390,007                                            |  | *                     |  
|Charles A. Rowland, Jr.(h)(l)                                                                              |  | 246,916                                            |  | *                     |  
|Nancy J. Wysenski(h)(m)                                                                                    |  | 212,043                                            |  | *                     |  
|Joyce N. LaViscount(h)(n)                                                                                  |  | 92,677                                             |  | *                     |  
|All current directors and executive officers of Endo Pharmaceuticals Holdings Inc. as a group (12 persons) |  | 2,045,128                                          |  | 1.7                   | %
|                                                                                                           |  |                                                   
|Other Stockholders:                                                                                        |  |                                                    |  |                       |  
|D.E. Shaw Co., L.P. et. al (r)                                                                             |  | 13,190,341                                         |  | 10.8                  | %
|Capital Research and Management Co.(s)                                                                     |  | 12,300,000                                         |  | 10.1                  | %
|Barclays Global Investors, et. al. (t)                                                                     |  | 9,627,078                                          |  | 7.9                   | %
|Royce & Associates, LLC (u)                                                                                |  | 6,620,480                                          |  | 5.4                   | %



|* | The percentage of the class to be owned by such security holder represents less than 1%.
|- | ----------------------------------------------------------------------------------------



|(a) | Beneficial ownership is a term broadly defined by the SEC in Rule 13d-3 under the Exchange Act, and includes more than the typical form of stock ownership, that is,
stock held in the persons name. The term also includes what is referred to as indirect ownership, meaning ownership of shares as to which a person has or shares investment power. For purposes of this table, a person or group of
persons is deemed to have beneficial ownership of any shares as of a given date that such person has the right to acquire in the future.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(b) | Mr. Delucca is a director of our company. The business address for Mr. Delucca is 314 Ardmore Road, Ho-Ho-Kus, NJ 07423. Mr. Deluccas
beneficial ownership represents (i) options to purchase 21,331 shares of common stock granted under the Endo Pharmaceuticals Holdings Inc. 2004 and 2007 Stock
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| | Incentive Plans, 6,142 of which are exercisable within 60 days, (ii) 2,262 shares of restricted stock granted under the Endo Pharmaceuticals Holdings
Inc. 2000 Stock Incentive Plan, 1,131 of which are fully vested and (iii) 2,741 shares underlying restricted stock units, granted under the Endo Pharmaceuticals Holdings Inc. 2007 Stock Incentive Plan.
| | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(c) | Mr. de Rosen is a director of our company. The business address for Mr. de Rosen is c/o ViroPharma Incorporated, 397 Eagleview Boulevard, Exton, PA 19341. Mr. de
Rosens beneficial ownership represents (i) options to purchase 21,331 shares of common stock granted under the Endo Pharmaceuticals Holdings Inc. 2000 and 2007 Stock Incentive Plans, 3,642 of which are exercisable within 60 days,
(ii) 2,262 shares of restricted stock granted under the Endo Pharmaceuticals Holdings Inc. 2000 Stock Incentive Plan, 1,131 of which are fully vested, (iii) 2,741 shares underlying restricted stock units granted under the Endo
Pharmaceuticals Holdings Inc. 2007 Stock Incentive Plan and (4) 157 shares of Endo common stock.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(d) | Mr. Horner is a director of our company. The business address for Mr. Horner is c/o Prestwick Pharmaceuticals, 1825 K Street NW, Suite 1475, Washington DC.
Mr. Horners beneficial ownership represents (i) options to purchase 21,331 shares of common stock under the Endo Pharmaceuticals Holdings Inc. 2004 and 2007 Stock Incentive Plans, 3,642 of which are exercisable within 60 days
(ii) 2,262 shares of restricted stock granted under the Endo Pharmaceuticals Holdings Inc. 2000 Stock Incentive Plan, 1,131 of which are fully vested and (iii) 2,741 shares underlying restricted stock units granted under the Endo
Pharmaceuticals Holdings Inc. 2007 Stock Incentive Plan.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(e) | Mr. Hyatt is a director of Endo. The business address for Mr. Hyatt is c/o Bear, Stearns & Co. Inc., 383 Madison Avenue, New York, New York 10179.
Mr. Hyatts beneficial ownership includes (i) 225,000 shares of common stock owned directly by Mr. Hyatt, (ii) 20,750 shares held in trusts for which Mr. Hyatt serves as trustee and as to which shares Mr. Hyatt
holds either the sole or the shared power of disposition or the power to vote, (iii) options to purchase 61,331 shares of common stock granted under the Endo Pharmaceuticals Holdings Inc. 2000, 2004 and 2007 Stock Incentive Plans, 43,642
of which are exercisable within 60 days, (iv) 2,262 shares of restricted stock granted under the Endo Pharmaceuticals Holdings Inc. 2000 Stock Incentive Plan, 1,131 of which are fully vested and (v) 2,741 shares underlying restricted stock
units granted under the Endo Pharmaceuticals Holdings Inc. 2007 Stock Incentive Plan. Mr. Hyatts beneficial ownership excludes 25,000 shares of common stock held in a trust for the benefit of the children of Mr. Hyatt, as to which
shares Mr. Hyatt has neither the power of disposition nor the power to vote.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(f) | Mr. Kimmel is the Chairman of the Board of Endo. The business address for Mr. Kimmel is c/o Rothschild, Inc., 1251 Avenue of the Americas, New York, New York 10022.
Mr. Kimmels beneficial ownership includes (i) 165,400 shares of common stock held in trusts for which Mr. Kimmel serves as trustee and as to which shares Mr. Kimmel holds either the sole or the shared power of
disposition and power to vote, (ii) options to purchase 45,072 shares of common stock granted under the Endo Pharmaceuticals Holdings Inc. 2000, 2004 and 2007 Stock Incentive Plans, 27,383 of which are exercisable within 60 days,
(iii) 2,262 shares of restricted stock granted under the Endo Pharmaceuticals Holdings Inc. 2000 Stock Incentive Plan, 1,131 of which are fully vested, (iv) 1,723 shares of common stock which Mr. Kimmel has elected to defer receipt of
under the Endo Pharmaceuticals Deferred Compensation Plan and (v) 2,741 shares underlying restricted stock units granted under the Endo Pharmaceuticals Holdings Inc. 2007 Stock Incentive Plan. Mr. Kimmels beneficial ownership
excludes a total of 15,000 shares of common stock held in trusts for the benefit of Mr. Kimmels adult children, as to which shares Mr. Kimmel has neither the power of disposition nor the power to vote.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(g) | Dr. Meanwell is a director of Endo. The business address for Dr. Meanwell is c/o The Medicines Company, 5 Sylvan Way, Parsippany, New Jersey 07054.
Dr. Meanwells beneficial ownership represents (i) options to purchase 46,331 shares of our common stock granted under the Endo Pharmaceuticals
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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##### Table of Contents

| | Holdings Inc. 2000, 2004 and 2007 Stock Incentive Plans, 28,642 of which are exercisable within 60 days, (ii) 2,262 shares of restricted stock
granted under the Endo Pharmaceuticals Holdings Inc. 2000 Stock Incentive Plan, 1,131 of which are fully vested and (iii) 2,741 shares underlying restricted stock units granted under the Endo Pharmaceuticals Holdings Inc. 2007 Stock Incentive
Plan.
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(h) | The business address for this person is c/o Endo Pharmaceuticals Holdings Inc., 100 Endo Boulevard, Chadds Ford, Pennsylvania 19317.
|--- | ------------------------------------------------------------------------------------------------------------------------------------



|(i) | Mr. Holveck is our President and Chief Executive Officer, effective April 1, 2008 and a Director of the Company effective March 25, 2008. Mr. Holvecks
beneficial ownership includes (i) 46,088 shares underlying restricted stock units and (ii) 188,632 shares underlying options granted under the Endo Pharmaceuticals Holdings Inc. 2007 Stock Incentive Plan, none of which are exercisable
within 60 days.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(j) | Dr. Lee is our Chief Scientific Officer. Dr. Lee owns 0.02% of Endo Pharma LLC and may be deemed to share beneficial ownership of shares of common stock owned of record by
Endo Pharma LLC by virtue of his status as a member of Endo Pharma LLC. Dr. Lee shares voting power along with the other members of Endo Pharma LLC with respect to shares of common stock owned by Endo Pharma LLC, but disclaims beneficial
ownership of such securities except to the extent of his pecuniary interest. Dr. Lees beneficial ownership includes (i) 185,754 shares, which are held in the Lee 2007 Grantor Retained Annuity Trust, for which Dr. Lee serves as
trustee and as to which shares Dr. Lee holds either the sole or the shared power of disposition and power to vote and (ii) options to purchase 20,435 shares of our common stock granted under the Endo Pharmaceuticals Holdings Inc. 2007
Stock Incentive Plan, none of which are exercisable within 60 days and (iii) 2,801 shares underlying restricted stock units granted under the Endo Pharmaceuticals Holdings Inc. 2007 Stock Incentive Plan.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(k) | Ms. Manogue is our Executive Vice President, Chief Legal Officer and Secretary. Ms. Manogues beneficial ownership includes (i) 30,835 shares of Endo common
stock, (ii) 353,589 shares underlying options granted under the Endo Pharmaceuticals Holdings Inc. 2000, 2004 and 2007 Stock Incentive Plans, 161,011 of which are exercisable within 60 days and (iii) 5,583 shares underlying restricted
stock units.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(l) | Mr. Rowland is our Executive Vice President, Chief Financial Officer and Treasurer. Mr. Rowlands beneficial ownership includes (i) 240,237 shares underlying
options granted under the Endo Pharmaceuticals Holdings Inc. 2004 and 2007 Stock Incentive Plans, 29,088 of which are exercisable within 60 days and (ii) 6,699 shares underlying restricted stock units granted under the Endo Pharmaceuticals
Holdings Inc. 2007 Stock Incentive Plan.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(m) | Ms. Wysenski has been our Chief Operating Officer since September 6, 2007. Ms. Wysenskis beneficial ownership includes (i) 207,577 shares underlying
options granted under the Endo Pharmaceuticals Holdings Inc. 2004 and 2007 Stock Incentive Plans, none of which are exercisable within 60 days and (ii) 4,466 shares underlying restricted stock units granted under the Endo Pharmaceuticals
Holdings Inc. 2007 Stock Incentive Plan.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(n) | Ms. LaViscount has been our Chief Accounting Officer since August 9, 2006. Ms. LaViscounts beneficial ownership includes (i) 89,402 shares underlying
options granted under the Endo Pharmaceuticals Holdings Inc. 2004 Stock Incentive Plan, 28,142 of which are exercisable within 60 days and (ii) 3,275 shares underlying restricted stock units granted under the Endo Pharmaceuticals
Holdings Inc. 2007 Stock Incentive Plan.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(r) | The business address for this entity is 120 West Forty-Fifth Street, 39thFloor, Tower 45, New York, NY 10036. This ownership information is based on a written statement from the stockholder received by the Company on February 28, 2008, which claims
that the shares are held for investment purposes and states that it holds the voting power and investment discretion to acquire additional shares through open market purchases or otherwise, sell, trade, engage in short selling of, hedge, or enter
into any similar transactions with respect to the shares through the open market or otherwise, or engage or participate in a transaction
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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##### Table of Contents

| | with the purpose or effect of changing or influencing the control of the issuer. Of the total shares beneficially owned, 13,186,641 shares are beneficially
owned by D.E. Shaw Valence Portfolios, L.L.C. (Valence) and 3,700 shares are beneficially owned by D.E. Shaw Investment Management, L.L.C. (DESIM). Valence has voting and investment powers as follows: sole voting0 shares; shared
voting13,186,641 shares; sole dispositive0 shares; and shared dispositive13,186,641 shares. DESIM has voting and investment powers as follows: sole voting0 shares; shared voting3,700 shares; sole dispositive0
shares; and shared dispositive3,700 shares. The 13,186,641 shares set forth above, include (a) 13,161,641 common shares and (b) the right to acquire 25,000 common shares through the exercise of listed call options.
| | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(s) | The business address for this entity is 333 South Hope Street, Los Angeles, California, 90017. This ownership information is based on a written statement from the stockholder
received by the Company on February 12, 2007, which disclaims any beneficial economic interest in any of the shares, and states that it holds the voting power and/or investment discretion solely in a fiduciary capacity as an investment advisor
for its clients, none of which individually owns more than 5% of the Companys common stock. Of the total shares beneficially owned, the stockholder has voting and investment powers as follows: sole voting7,000,000 shares; shared
voting0 shares; sole dispositive12,300,000 shares; and shared dispositive0 shares.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(t) | This ownership information is based on a written statement from the stockholder received by the Company on
February 5, 2008, which disclaims any beneficial economic interest in any of the shares, and states that it holds the voting power and/or investment discretion solely in a fiduciary capacity as an investment advisor for its clients, none of
which individually owns more than 5% of the Companys common stock. Of the total shares beneficially owned, 6,695,333 shares are beneficially owned by Barclays Global Investors, NA (Global Investors) having a business address of 45 Fremont
Street, San Francisco, California, 94105; 2,551,886 shares are beneficially owned by Barclays Global Fund Advisors (Fund Advisors) having a business address of 45 Fremont Street, San Francisco, California, 94105; 267,347 shares are beneficially
owned by Barclays Investors, LTD (Investors LTD) having a business address of Murray House, 1 Royal Mint Court, London, EC3N 4HH, England; 78,757 shares are beneficially owned by Barclays Global Investors Japan Limited (Japan Limited) having a
business address of Ebisu Prime Square Tower 8thFloor, 1-1-39 Hiroo Shibuya-Ku, Tokyo 150-0012, Japan; and 33,755 shares are beneficially owned by
Barclays Global Investors Canada Limited (Canada Limited), having a business address of Brookfield Place 161 Bay Street, Suite 2500, PO Box 614, Toronto, Canada, Ontario M5J 2S1. Global Investors has voting and investment powers as follows: sole
voting5,625,308 shares; shared voting0 shares; sole dispositive6,695,333 shares; and shared dispositive0 shares. Fund Advisors has voting and investment powers as follows: sole voting2,551,886 shares; shared
voting0 shares; sole dispositive2,551,886 shares; and shared dispositive0 shares. Investors LTD has voting and investment powers as follows: sole voting198,114 shares; shared voting0 shares; sole
dispositive267,347 shares; and shared dispositive0 shares. Japan Limited has voting and investment powers as follows: sole voting78,757 shares; shared voting0 shares; sole dispositive78,757 shares; and shared
dispositive0 shares. Canada Limited has voting and investment powers as follows: sole voting33,755 shares; shared voting0 shares; sole dispositive33,755 shares; and shared dispositive0 shares.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(u) | The business address for this entity is 1414 Avenue of the Americas, New York, New York 10019. This ownership information is based on a written statement from the stockholder
received by the Company on February 5, 2008, which disclaims any beneficial economic interest in any of the shares, and states that it holds the voting power and/or investment discretion solely in a fiduciary capacity as an investment advisor
for its clients, none of which individually owns more than 5% of the Companys common stock. Of the total shares beneficially owned, the stockholder has voting and investment powers as follows: sole voting6,620,480 shares; shared
voting0 shares; sole dispositive6,620,480 shares; and shared dispositive0 shares.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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##### Table of Contents

Equity Compensation Plan Information.The following information relates to plans in effect as of
December 31, 2007 under which equity securities of Endo may be issued to employees and directors. Although the Endo Pharmaceuticals Holdings Inc. 2000, 2004 and 2007 Stock Incentive Plans provide that stock options may be granted thereunder to
non-employee consultants, Endo has never granted any such options to any such consultants.



|                                                             |  |                                                                                         |  |                                                                         |  |                                                                                                                                      
|------------------------------------------------------------ |  | --------------------------------------------------------------------------------------- |  | ----------------------------------------------------------------------- |  | -------------------------------------------------------------------------------------------------------------------------------------
|                                                             |  | Column A                                                                                |  | Column B                                                                |  | Column C                                                                                                                             
|Plan Category                                                |  | Number of securitiesto be issued uponexercise ofoutstanding options,warrants and
rights |  | Weighted-averageexercise price ofoutstandingoptions,warrants and rights |  | Number of securities remainingavailable for future issuanceunder equity compensationplans (excluding
securitiesreflected in Column A)
|Equity compensation plans approved by security holders       |  |                                                                                         |  |                                                                         |  |                                                                                                                                      
|Endo Pharmaceuticals Holdings Inc. 2000 Stock Incentive Plan |  | 1,680,114                                                                               |  | 17.44                                                                   |  | 47,319                                                                                                                               
|Endo Pharmaceuticals Holdings Inc. 2004 Stock Incentive Plan |  | 2,655,938                                                                               |  | 28.54                                                                   |  | 1,223,688                                                                                                                            
|Endo Pharmaceuticals Holdings Inc. 2007 Stock Incentive Plan |  |                                                                                        |  |                                                                        |  | 7,000,000                                                                                                                            
|                                                             |  |                                                                                         | 
|Equity compensation plans not approved by security holders   |  |                                                                                         |  |                                                                         |  |                                                                                                                                      
|Not Applicable                                               |  |                                                                                         |  |                                                                         |  |                                                                                                                                      



|Item 13. | Certain Relationships and Related Transactions, and Director Independence
|-------- | -------------------------------------------------------------------------

Review and Approval of Transactions with Related Persons

The Board of Directors has adopted written
policies and procedures for review, approval and monitoring of transactions involving the Company and related persons (directors and executive officers or their immediate family members, or stockholders owning five percent or greater of
the Companys outstanding stock). The policy covers any related person transaction that meets the minimum threshold for disclosure under the relevant SEC rules (generally, transactions involving amounts exceeding $120,000 in which a related
person has a direct or indirect material interest).

The policy is as follows:



| |  |  | Related person transactions must be approved by the Board of Directors or by a committee of the Board consisting solely of independent directors, who will approve
the transaction only if they determine that it is in the best interests of the Company. In considering the transaction, the Board of Directors or committee will consider all relevant factors, including as applicable (i) the Companys
business rationale for entering into the transaction; (ii) the alternatives to entering into a related person transaction; (iii) whether the transaction is on terms comparable to those available to third parties, or in the case of
employment relationships, to employees generally; (iv) the potential for the transaction to lead to an actual or apparent conflict of interest and any safeguards imposed to prevent such actual or apparent conflicts; and (v) the overall
fairness of the transaction to the Company.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The Board of Directors or relevant committee will periodically monitor the transaction to ensure that there are no changed circumstances that would render it
advisable for the Company to amend or terminate the transaction.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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The procedures are as follows:



| |  |  | Management or the affected director or executive officer will bring the matter to the attention of the Chairman, the chair of the Nominating & Governance
Committee or the Secretary.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The Chairman shall determine (or if he is involved in the transaction, the Nominating & Governance Committee shall determine) whether the matter should be
considered by the Board of Directors or by one of its existing committees consisting only of independent directors.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | If a director is involved in the transaction, he or she will be recused from all discussions and decisions about the transaction.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------



| |  |  | The transaction must be approved in advance whenever practicable, and if not practicable, must be ratified as promptly as practicable
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The Board of Directors or relevant committee will review each transaction annually to determine whether it continues to be in the Companys best interests.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------

Transactions with Related Persons, Promoters and Certain Control Persons

In connection with the Companys acquisition of Algos Pharmaceutical Corporation, affiliates and designees of Kelso & Company contributed
all of their shares of Endo common stock to Endo Pharma LLC. This contribution represented approximately 86% of the Endo common stock originally contributed to Endo Pharma LLC, and these contributors continue to own an approximately 86% interest in
Endo Pharma LLC. Endo Pharma LLC is a limited liability company that had at one point held a majority of our common stock (but that is no longer affiliated with us), and in which affiliates of Kelso & Company and a certain member of
management have an interest. Endo Pharma LLC does not own any shares of Endo common stock.

Tax Sharing Agreement.On
July 14, 2000, Endo Pharma LLC was formed in connection with our merger with Algos Pharmaceutical Corporation (Algos) to ensure that the stock options granted pursuant to the Endo Pharma LLC Stock Option Plans diluted only the Endo common stock
held by persons and entities that held such shares prior to our merger with Algos. Endo Pharma LLC is a limited liability company that is no longer affiliated with the Company but had historically held significant portions of our common stock, in
which affiliates of Kelso & Company and certain current and former members of management have an interest. Upon the exercise of these stock options, only currently outstanding shares of our common stock held by Endo Pharma LLC were
delivered. Because Endo Pharma LLC, and not us, had provided the shares upon the exercise of these options, we entered into a tax sharing agreement (as amended) with Endo Pharma LLC under which we are required to pay to Endo Pharma LLC the
amount of the tax benefits usable by us as a result of the exercise of these stock options into shares of our common stock held by Endo Pharma LLC. As of December 31, 2007, all 36 million of these stock options had been exercised into
shares of our common stock held by Endo Pharma LLC. Upon exercise of any of these Endo Pharma LLC stock options, we are generally permitted to deduct as a compensation charge, for federal income tax purposes, an amount equal to the difference
between the market price of our common stock and the exercise price paid upon exercise of these options (as of December 31, 2007, approximately $775 million), which is estimated to result in a tax benefit amount of approximately $298 million.
Under the tax sharing agreement, we are required to pay this $298 million, $291 million of which has already been paid as of December 31, 2007, to Endo Pharma LLC to the extent that a compensation charge deduction is usable by us to reduce our
taxes and based upon the assumption that all other deductions of Endo are used prior thereto. Additionally, as part of the tax sharing agreement, Endo Pharma LLC will reimburse us for the after-tax employer payroll taxes paid by us as a result of
the exercise of the 36 million options discussed above. We have paid approximately $12 million in employer payroll taxes, of which Endo Pharma LLC will reimburse us for approximately $7 million, which represents the after-tax employer payroll
tax paid by us for the periods from 2001 through December 31, 2007. As of December 31, 2007, our net liability due to Endo



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Pharma LLC was approximately $0.7 million, which relates to Endo Pharma LLC options exercised during 2007. All payments made and accrued pursuant to the tax
sharing agreement have been reflected as a reduction of stockholders equity in the accompanying financial statements.

During the
year ended December 31, 2007, the final 75,259 shares underlying stock options granted under the Endo Pharma LLC stock option plans were exercised. Since we expect the attributable compensation charge deductions to be usable to reduce our taxes
in 2007, we are obligated, under our amended tax sharing agreement, to pay to Endo Pharma LLC an additional tax benefit amount of approximately $0.7 million, which is included in our net liability due to Endo Pharma LLC referred to above. Fifty
percent of the estimated tax benefit amount attributable to these exercises and any additional tax benefits attributable to the exercise of stock options granted under the Endo Pharma LLC stock option plans in 2007 will be due within 15 business
days of the date we receive a report on our final audited 2007 financial statements from our independent registered public accounting firm, and the remaining tax benefit amount attributable to 2007 is due within 30 business days of the date on which
we file our 2007 tax return with the Internal Revenue Service. This will represent the final tax sharing payment due to Endo Pharma LLC. The Company and Endo Pharma LLC terminated the tax sharing agreement on December 31, 2007, and the Company
paid Endo Pharma LLC $0.8 million in settlement of all of the Companys obligations under the tax sharing agreement.

As of
December 31, 2007, there were no options remaining to be granted under the Endo Pharma LLC stock option plans.

Payment to Ms.
Ammon.In March 2006, Endo Pharma LLC informed us that, in connection with its eventual winding-up, it would make a special allocation to Ms. Carol Ammon, our former Chairman of the Board and former Chief Executive Officer, of
approximately $22 million, with all or a portion of Ms. Ammons payment being satisfied by granting to her the remaining unallocated Endo Pharma LLC stock options representing approximately 0.8 million shares under the Endo Pharma LLC
stock option plans. This amount has been recorded in selling, general and administrative expenses during the year ended December 31, 2006 and as a capital contribution by Endo Pharma LLC. This grant of options to Ms. Ammon was made during
the fourth quarter of 2006. The 0.8 million options were granted by Endo Pharma LLC to Ms. Ammon in the fourth quarter of 2006, as described above, at an exercise price of $2.42 per share. Therefore, approximately $20 million of the
approximately $22 million recorded in the first quarter of 2006 was reclassified as a stock compensation expense representing the fair value of the option on the date of grant. These options were immediately vested and exercised by Ms. Ammon
and the resulting compensation charge deduction of approximately $19 million and the resulting tax sharing obligation to Endo Pharma LLC is included in our tax sharing liability discussed above. Endo Pharma LLC funded the remaining $2 million to
Ms. Ammon in June 2007.

Related Party Matters.Robert Ammon, the brother of our former Chairman and former Chief
Executive Officer, is employed by the Company as a senior national account executive and has been since our founding as a private company in 1997. Mr. Ammons 2007 total compensation, including base salary, incentive compensation,
long-term incentive compensation and all benefits (including health benefits), was approximately $254,000. Marisa ODonnell, the daughter of Peter A. Lankau our former President and Chief Executive Officer, whose resignation was effective
March 1, 2008, is employed by us as a sales representative and has been since 2006. Ms. ODonnells 2007 total compensation, including base salary, incentive compensation, long-term incentive compensation and all benefits
(including health benefits), was approximately $100,000. Both Mr. Ammons and Ms. ODonnells total 2007 compensation is commensurate with other Endo employees that have the same or similar job responsibilities.

Mr. Hyatt, a director of the Company, is a Senior Managing Director of Bear, Stearns & Co., Inc., an investment bank that performs
services for the Company from time to time. No amounts were paid to Bear, Stearns & Co., Inc. in fiscal 2007.



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Director Independence

Currently, the Board of Directors consists of seven members. Currently serving as directors are Roger H. Kimmel, John J. Delucca, Michel de Rosen, David
P. Holveck, George F. Horner, III, Michael Hyatt and Clive A. Meanwell, M.D., Ph.D. The Board of Directors has affirmatively determined that six of its seven current members are independent directors under the NASDAQ rules and
regulations. The six independent directors under the NASDAQ rules and regulations are Messrs. Delucca, de Rosen, Horner, Hyatt, Kimmel and Dr. Meanwell.

The Board annually determines the independence of directors based on a review by the directors and the Nominating & Governance Committee. No director is considered independent unless the Board of Directors
has determined that he or she has no material relationship with the Company, either directly or as a partner, shareholder, or officer of an organization that has a material relationship with the Company. Material relationships can include
commercial, industrial, banking, consulting, legal, accounting, charitable, and familial relationships, among others. To evaluate the materiality of any such relationship, the Board has adopted categorical independence standards consistent with the
NASDAQ Exchange listing guidelines. These standards are available on the Companys website at www.endo.com, under Investors-Corporate Governance.

Specifically, a director is not considered independent if (i) the director or an immediate family member is a current partner of Endos independent auditor (currently Deloitte & Touche LLP);
(ii) the director is a current employee of such firm; (iii) the director has an immediate family member who is a current employee of such firm and who participates in the firms audit, assurance, or tax compliance (but not tax
planning) practice; or (iv) the director or immediate family member was within the last three years (but is no longer) a partner or employee of such firm and personally worked on the listed companys audit within that time.

In addition, a director is not considered independent if any of the following relationships existed within the previous three years:



| |  |  | a director who is an employee of Endo, or whose immediate family member is an executive officer of Endo.
| | - |  | --------------------------------------------------------------------------------------------------------



| |  |  | a director who receives any direct compensation from Endo other than the directors normal director compensation, or whose immediate family member receives
more than $60,000 in any one twelve consecutive month period in direct compensation from Endo other than for service as a non-executive employee.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | a director who is employed (or whose immediate family member is employed as an executive officer) by another company where any Endo executive officer serves on that
companys compensation committee.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | a director who is, or whose immediate family member is, a partner in, a controlling shareholder or an executive officer of any organization that makes payments to
or receives payments from Endo for property or services that exceed the greater of 5% of the recipients consolidated gross revenues for that year, or $200,000, whichever is more.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Members of the Audit, Compensation, and Nominating & Governance Committees must meet applicable independence tests of the NASDAQ.

In February 2008, the directors and Nominating & Governance Committee reviewed directors responses to a questionnaire asking about
their relationships with the company (and those of their immediate



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family members) and other potential conflicts of interest, as well as material provided by management related to transactions, relationships, or arrangements
between the Company and the directors or parties related to the directors. The Nominating & Governance Committee determined that all six non-employee directors listed above are independent, and that the members of the Audit, Compensation,
and Nominating & Governance Committees also meet the independence tests referenced above. The committee recommended this determination to the Board of Directors and explained the basis for its decision, and this determination was adopted by
the full Board. The committee and the Board determined that none of the six directors listed above has had during the last three years (i) any of the relationships listed above or (ii) any other material relationship with the Company that
would compromise his independence. The table below includes a description of categories or types of transactions, relationships, or arrangements considered by our Board of Directors (in addition to those listed above) in reaching its determination
that the directors are independent.



|                               |  |             |  |                                        
|------------------------------ |  | ----------- |  | ---------------------------------------
|Name                           |  | Independent |  | Transactions/Relationships/Arrangements
|                               |  |            
|John J. Delucca                |  | Yes         |  | None                                   
|                               |  |            
|Michel de Rosen                |  | Yes         |  | None                                   
|                               |  |            
|George F. Horner, III          |  | Yes         |  | None                                   
|                               |  |            
|Michael Hyatt                  |  | Yes         |  | *                                      
|                               |  |            
|Roger H. Kimmel                |  | Yes         |  | None                                   
|                               |  |            
|Clive A. Meanwell, M.D., Ph.D. |  | Yes         |  | None                                   





*Mr. Hyatt is a Senior Managing Director of Bear, Stearns & Co., Inc., an investment bank that performs services for the Company from time to time. During
2006, the Company reimbursed Bear, Stearns & Co., Inc. for expenses totaling $59,643, which were incurred in connection with sales of Company common stock by certain of our shareholders, including Endo Pharma LLC (which is no longer
affiliated with the Company, but which is an affiliate of Kelso & Company in which a certain member of management has an interest). No amounts were paid to Bear, Stearns & Co., Inc. during 2007.

As of the date hereof, there are no material proceedings to which any director or executive officer of the Company, or any associate thereof, is a party
that are adverse to the Company or any of its subsidiaries.



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|Item 14. | Principal Accountant Fees and Services
|-------- | --------------------------------------

Deloitte & Touche LLP, the member firms of Deloitte Touche Tohmatsu, and their respective affiliates (collectively, the Deloitte Entities) served as the Companys independent registered
public accounting firm for the fiscal year ended December 31, 2007. The following table summarizes the aggregate fees for services the Deloitte Entities provided during fiscal years 2007 and 2006:



|                      |  |      |           |      |   |          
|--------------------- |  | ---- | --------- | ---- | - | ---------
|                      |  | 2007 |           | 2006
|Audit Fees(a)         |  | $    | 1,373,914 |      | $ | 1,106,595
|Audit-Related Fees(b) |  |      | 22,809    |      |   | 20,756   
|Tax Fees(c)           |  |      | 238,623   |      |   | 151,000  
|All Other Fees        |  |      |          |      |   |         
|                      |  |      |           |      |   |          
|Total                 |  | $    | 1,635,346 |      | $ | 1,278,351
|                      |  |      |           |      |   |          



|(a) | Fees for audit services billed in 2007 and 2006 consisted of:
|--- | -------------------------------------------------------------



| |  |  | Audit of the Companys annual financial statements
| | - |  | --------------------------------------------------



| |  |  | Evaluation and reporting on the effectiveness of the Companys internal controls over financial reporting
| | - |  | ---------------------------------------------------------------------------------------------------------



| |  |  | Reviews of the Companys quarterly financial statements
| | - |  | -------------------------------------------------------



| |  |  | Comfort letters, consents and other services related to SEC matters
| | - |  | -------------------------------------------------------------------



|(b) | Fees for audit-related services billed in 2007 and 2006 consisted of:
|--- | ---------------------------------------------------------------------



| |  |  | Employee benefit plan audits
| | - |  | ----------------------------



|(c) | Fees for tax services billed in 2007 and 2006 consisted of tax compliance and tax planning and advice:
|--- | ------------------------------------------------------------------------------------------------------



| |  |  | Tax compliance services are services rendered based upon facts already in existence or transactions that have already occurred to document, compute, and obtain
government approval for amounts to be included in tax filings and consisted of:
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | i. | Federal, state and local income tax return assistance
| | -- | -----------------------------------------------------



| | ii. | Sales and use, property and other tax return assistance
| | --- | -------------------------------------------------------



| | iii. | Assistance with tax return filings in certain foreign jurisdictions
| | ---- | -------------------------------------------------------------------



| |  |  | The Company generally does not engage the Deloitte Entities for other services.
| | - |  | ---------------------------------------------------------------------------------

In considering the nature of the services provided by the Deloitte Entities, the Audit Committee determined that such services are compatible with the
provision of independent audit services. The Audit Committee discussed these services with the Deloitte Entities and Company management to determine that they are permitted under the rules and regulations concerning auditor independence promulgated
by the SEC to implement the Sarbanes-Oxley Act of 2002, as well as the American Institute of Certified Public Accountants.

Pre-Approval Policy

Consistent with SEC policies regarding auditor independence, the Audit Committee has responsibility for appointing, setting
compensation and overseeing the work of the independent registered public accounting firm. In recognition of this responsibility, the Audit Committee has established a policy to pre-approve all audit and permissible non-audit services provided by
the independent registered public accounting firm.



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Prior to the engagement of the independent registered public accounting firm for the next years
audit, management will submit a list of services and related fees expected to be rendered during that year within each of the four categories of services to the Audit Committee for approval.



| | 1. | Auditservices include audit work performed on the financial statements and related to the evaluation and reporting on the effectiveness of the Companys internal
control over financial reporting, as well as work that generally only the independent registered public accounting firm can reasonably be expected to provide, including comfort letters, consents and other services related to SEC matters, and
discussion surrounding the proper application of financial accounting and/or reporting standards.
| | -- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 2. | Audit-Relatedservices are for assurance and related services that are traditionally performed by the independent registered public accounting firm, including due diligence
related to mergers and acquisitions and employee benefit plan audits.
| | -- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 3. | Taxservices include all services, except those services specifically related to the audit of the financial statements, performed by the independent registered public
accounting firms tax personnel, including tax analysis; assisting with the coordination of execution of tax related activities, primarily in the area of corporate developments; supporting other tax related regulatory requirements; and tax
compliance and reporting.
| | -- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 4. | Other Feesare those associated with services not captured in the other categories. The Company generally does not request such services from the independent registered
public accounting firm.
| | -- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Prior to engagement, the Audit Committee pre-approves the independent registered public accounting
firms services within each category. The fees are budgeted and the Audit Committee requires the independent registered public accounting firm and management to report actual fees versus budget periodically throughout the year by category of
service. During the year, circumstances may arise when it may become necessary to engage the independent registered public accounting firm for additional services not contemplated in the original pre-approval categories. In those instances, the
Audit Committee requires specific pre-approval before engaging the independent registered public accounting firm.

The Audit Committee may
delegate pre-approval authority to one or more of its members. The member whom such authority is delegated must report, for informational purposes only, any pre-approval decisions to the Audit Committee at its next scheduled meeting.

PART IV



|Item 15. | Exhibits, Financial Statement Schedules
|-------- | ---------------------------------------

Documents filed as part of this Annual Report on Form 10-K



|1. | Consolidated Financial Statements: See accompanying Index to Consolidated Financial Statements.
|-- | -----------------------------------------------------------------------------------------------

Reference is made to the Index to Consolidated Financial Statements on Page F-1 of this Annual Report on Form 10-K as initially filed on February 26,
2008.



|2. | Consolidated Financial Statement Schedule:
|-- | ------------------------------------------

Reference is
made to the Consolidated Financial Statements Schedule on Page 75 of this Annual Report on Form 10-K as initially filed on February 26, 2008.



|3. | Exhibits
|-- | --------

The exhibits on the accompanying Exhibit Index
are filed as part of, or furnished with, or incorporated by reference into, this Annual Report on Form 10-K/A.



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SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange of 1934, the
Registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.



|                                                |  |                                                                
|----------------------------------------------- |  | ---------------------------------------------------------------
|ENDO PHARMACEUTICALS HOLDINGS INC.
(Registrant)
|                                               
|/s/ Charles A. Rowland, Jr.                    
|Name:                                           |  | Charles A. Rowland, Jr.                                        
|Title:                                          |  | Executive Vice President, Chief Financial
Officer and Treasurer

Date: April 29, 2008



Pursuant to the requirements of the Securities Exchange of 1934, this report has been signed below by the following persons on behalf of the Registrant
and in the capacities and on the dates indicated.



|                                                    |  |                                                                                               |  |                                                                                        |  |               
|--------------------------------------------------- |  | --------------------------------------------------------------------------------------------- |  | -------------------------------------------------------------------------------------- |  | --------------
|Signature                                           |  | Title                                                                                         |  | Date                                                                                  
|                                                    |  |                                                                                              
|/s/ David P. Holveck David P. Holveck               |  | President, Chief Executive Officer and Director (Principal Executive Officer)                 |  | April 29, 2008                                                                        
|                                                    |  |                                                                                              
|/s/ Charles A. Rowland, Jr. Charles A. Rowland, Jr. |  | Executive Vice President, Chief Financial Officer and
Treasurer (Principal Financial Officer) |  | April 29, 2008                                                                        
|                                                    |  |                                                                                              
|* Roger H.
Kimmel                                   |  | Chairman and Director                                                                         |  | April 29, 2008                                                                        
|                                                    |  |                                                                                              
|* John J.
Delucca                                   |  | Director                                                                                      |  | April 29, 2008                                                                        
|                                                    |  |                                                                                              
|* Michel de
Rosen                                   |  | Director                                                                                      |  | April 29, 2008                                                                        
|                                                    |  |                                                                                              
|* Michael
Hyatt                                     |  | Director                                                                                      |  | April 29, 2008                                                                        
|                                                    |  |                                                                                              
|* Clive A.
Meanwell, M.D., Ph.D.                    |  | Director                                                                                      |  | April 29, 2008                                                                        
|                                                    |  |                                                                                              
|* George F.
Horner, III                             |  | Director                                                                                      |  | April 29, 2008                                                                        
|                                                    |  |                                                                                               | 
|*By:                                                |  | /s/ Caroline B. Manogue Caroline B. Manogue                                                   |  | Attorney-in-fact, pursuant to a Power of Attorney
filed with this Report as Exhibit 24 |  | April 29, 2008



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Exhibit Index



|            |  |                                                                                                                                                                                                                                                                                                                                                                                                                                  
|----------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  | Title                                                                                                                                                                                                                                                                                                                                                                                                                            
|3.1         |  | Amended and Restated Certificate of Incorporation of Endo Pharmaceuticals Holdings Inc. (Endo) (incorporated herein by reference to Exhibit 3.1 of the Form 10-Q for the Quarter ended
June 30, 2000 filed with the Commission on August 15, 2000)                                                                                                                                                                             
|            | 
|3.2         |  | Amended and Restated By-laws of Endo (incorporated herein by reference to Exhibit 3.2 of the Form 10-Q for the Quarter ended March 31, 2003 filed with the Commission on May 14, 2003)                                                                                                                                                                                                                                           
|            | 
|4.1         |  | Amended and Restated Executive Stockholders Agreement, dated as of July 7, 2003, by and among Endo, Endo Pharma LLC (Endo LLC), Kelso Investment Associates V, L.P. (KIA
V), Kelso Equity Partners V, L.P. (KEP V) and the Management Stockholders (as defined therein) (incorporated herein by reference to Exhibit 4.1 of the Form 10-Q for the Quarter ended June 30, 2003 filed with the Commission on
August 14, 2003)
|            | 
|4.1.2       |  | Amendment to Amended and Restated Executive Stockholders Agreement, dated as of June 28, 2004, by and among Endo, Endo LLC, KIA V, KEP V and the Management Stockholders (as defined therein)
(incorporated herein by reference to Exhibit 4.1 of the Form 10-Q for the Quarter ended September 30, 2004 filed with the Commission on November 5, 2004) the Commission on July 1, 2003)                                          
|            | 
|4.1.3       |  | Amendment 2 to the Amended and Restated Stockholders Agreement, dated September 20, 2005, by and among the Company, Endo LLC, Kelso and certain Amending Stockholders (as defined therein)
(incorporated herein by reference to Exhibit 4.1.3 of the Current Report on Form 8-K filed with the Commission on September 22, 2005)                                                                                                 
|            | 
|4.2         |  | Amended and Restated Employee Stockholders Agreement, dated as of June 5, 2003, by and among Endo, Endo LLC, KIA V, KEP V and the Employee Stockholders (as defined therein) (incorporated
herein by reference to Exhibit 10.2 of Amendment No. 2 to the Form S-3 Registration Statement (Registration No. 333-105338) filed with the Commission on July 1, 2003)                                                                
|            | 
|4.2.2       |  | Amendment to Amended and Restated Employee Stockholders Agreement, dated as of June 28, 2004, by and among Endo, Endo LLC, KIA V, KEPV and the Management Stockholders (as defined therein)
(incorporated herein by reference to Exhibit 4.1 of the Form 10-Q for the Quarter ended September 30, 2004 filed with the Commission on November 5, 2004)                                                                            
|            | 
|4.2.3       |  | Amendment 2 to the Amended and Restated Employee Stockholders Agreement, dated September 20, 2005, by and among the Company, Endo LLC, Kelso and certain Amending Stockholders (as defined
therein) (incorporated herein by reference to Exhibit 4.2.3 of the Current Report on Form 8-K filed with the Commission on September 22, 2005)                                                                                        
|            | 
|4.3         |  | Employee Stockholders Consent and Release, effective September 20, 2005, by and among the Company, Endo LLC, Kelso and certain Employee Stockholders (as defined therein) signatory thereto
(incorporated herein by reference to Exhibit 4.3 of the Current Report on Form 8-K filed with the Commission on September 22, 2005)                                                                                                  



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##### Table of Contents

|      |  |                                                                                                                                                                                                                                                                                                                    
|----- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|      | 
|4.4   |  | Registration Rights Agreement, dated as of July 17, 2000, by and between Endo and Endo LLC (incorporated herein by reference to Exhibit 4.4 of the Form 10-Q for the Quarter ended
June 30, 2000 filed with the Commission on August 15, 2000)                                                                     
|      | 
|4.5   |  | Amendment to Registration Rights Agreement, dated as of June 30, 2003, by and between Endo and Endo LLC (incorporated herein by reference to Exhibit 10.1 of Amendment No. 2 to the Form S-3
Registration Statement (Registration No. 333-105338) filed with the Commission on July 1, 2003)                       
|      | 
|10.1  |  | Shelf Registration Agreement, dated September 21, 2005, by and between Endo, Endo LLC and certain Management Stockholders (as defined therein) (incorporated herein by reference to Exhibit
10.1 of the Current Report on Form 8-K filed with the Commission on September 22, 2005)                                
|      | 
|10.2  |  | Shelf Registration Agreement, dated April 30, 2004, between Endo Pharmaceuticals Holdings Inc. and Endo Pharma LLC (incorporated herein by reference to Exhibit 10.2 of Amendment No. 1 to
the Form S-3 Registration Statement (Registration No. 333-115032) filed with the Commission on June 10, 2004)           
|      | 
|10.3  |  | Amendment to Shelf Registration Agreement, dated June 10, 2004 between Endo Pharmaceuticals Holdings Inc. and Endo Pharma LLC (incorporated herein by reference to Exhibit 10.3 of Amendment
No. 1 to the Form S-3 Registration Statement (Registration No. 333-115032) filed with the Commission on June 10, 2004)
|      | 
|10.4  |  | [Intentionally Omitted.]                                                                                                                                                                                                                                                                                           
|      | 
|10.5  |  | [Intentionally Omitted.]                                                                                                                                                                                                                                                                                           
|      | 
|10.6  |  | Amended and Restated Tax Sharing Agreement, dated as of April 30, 2004 by and among Endo, Endo Inc. and Endo LLC (incorporated herein by reference to Exhibit 10.6 of the Form 10-Q for the
Quarter ended March 31, 2004 filed with the Commission on May 10, 2004)                                                
|      | 
|10.7  |  | [Intentionally Omitted]                                                                                                                                                                                                                                                                                            
|      | 
|10.8  |  | [Intentionally Omitted]                                                                                                                                                                                                                                                                                            
|      | 
|10.9  |  | [Intentionally Omitted]                                                                                                                                                                                                                                                                                            
|      | 
|10.10 |  | Sole and Exclusive License Agreement, dated as of November 23, 1998, by and between Endo Pharmaceuticals Inc. (Endo Pharmaceuticals) and Hind Health Care, Inc. (incorporated
herein by reference to Exhibit 10.10 of the Registration Statement filed with the Commission on June 9, 2000)                      
|      | 
|10.11 |  | Endo Pharmaceuticals Holdings Inc. Executive Deferred Compensation Plan (incorporated herein by reference to Exhibit 10.1 of the Current Report on Form 8-K dated December 19,
2007)                                                                                                                               
|      | 
|10.12 |  | Endo Pharmaceuticals Holdings Inc. 401(k) Restoration Plan (incorporated herein by reference to Exhibit 10.2 of the Current Report on Form 8-K dated December 19, 2007)                                                                                                                                            
|      | 
|10.13 |  | [Intentionally Omitted.]                                                                                                                                                                                                                                                                                           





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##### Table of Contents

|        |  |                                                                                                                                                                                                                                                                                                                                
|------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|        | 
|10.14   |  | Supply and Manufacturing Agreement, dated as of November 23, 1998, by and between Endo Pharmaceuticals and Teikoku Seiyaku Co., Ltd (incorporated herein by reference to Exhibit 10.14 of the
Registration Statement filed with the Commission on June 9, 2000)                                                                
|        | 
|10.14.1 |  | First Amendment, dated April 24, 2007, to the Supply and Manufacturing Agreement, dated as of November 23, 1998, by and between Endo Pharmaceuticals Inc. and Teikoku Seiyaku Co., Ltd. / Teikoku
Pharma USA, Inc. (incorporated herein by reference to Exhibit 10.14.1 of the Current Report on Form 8-K dated April 30, 2007)
|        | 
|10.15   |  | Supply Agreement, dated as of July 1, 1998, by and between Endo Pharmaceuticals and Mallinckrodt Inc. (Mallinckrodt) (incorporated herein by reference to Exhibit 10.15 of the
Registration Statement filed with the Commission on June 9, 2000)                                                                             
|        | 
|10.16   |  | Supply Agreement for Bulk Narcotics Raw Materials, dated as of July 1, 1998, by and between Endo Pharmaceuticals and Mallinckrodt (incorporated herein by reference to Exhibit 10.16 of the
Registration Statement filed with the Commission on June 9, 2000)                                                                  
|        | 
|10.16.1 |  | First Amendment, effective July 1, 2000, to the Supply Agreement for Bulk Narcotics Raw Materials, dated as of July 1, 1998, by and between Endo Pharmaceuticals and Mallinckrodt
(incorporated herein by reference to Exhibit 10.16.1 of the Current Report on Form 8-K dated April 14, 2006)                                 
|        | 
|10.16.2 |  | Second Amendment, dated April 10, 2006, to the Supply Agreement for Bulk Narcotics Raw Materials, dated as of July 1, 1998, by and between Endo Pharmaceuticals and Mallinckrodt
(incorporated herein by reference to Exhibit 10.16.2 of the Current Report on Form 8-K dated April 14, 2006)                                  
|        | 
|10.17   |  | [Intentionally Omitted.]                                                                                                                                                                                                                                                                                                       
|        | 
|10.18   |  | Amended and Restated Strategic Alliance Agreement, dated as of April 2, 2002, by and between Endo Pharmaceuticals and Penwest Pharmaceuticals Co. (incorporated herein by reference to
Exhibit 10.18 of the Quarterly Report on Form 10-Q for the Quarter Ended March 31, 2002 filed with the Commission on May 14, 2002)      
|        | 
|10.18.1 |  | Amendment, dated January 7, 2007, to the Amended and Restated Strategic Alliance Agreement, dated as of April 2, 2002, by and between Endo Pharmaceuticals Inc. and Penwest Pharmaceuticals Co.
(incorporated herein by reference to Exhibit 10.18.1 of the Current report on From 8-K dated January 11, 2007)                 
|        | 
|10.19   |  | Agreement, dated as of February 1, 2000, by and between Endo Pharmaceuticals and UPS Supply Chain Solutions, Inc. (f/d/b/a Livingston Healthcare Services Inc.) (incorporated herein by
reference to Exhibit 10.19 of the Registration Statement filed with the Commission on June 9, 2000)                                    
|        | 
|10.20   |  | Medical Affairs Support Services Agreement, dated as of June 1, 1999, by and between Endo Pharmaceuticals and Kunitz and Associates, Inc. (incorporated herein by reference to Exhibit 10.20
of the Registration Statement filed with the Commission on June 9, 2000)                                                          
|        | 
|10.21   |  | Endo Pharmaceuticals Holdings Inc. 2000 Stock Incentive Plan (incorporated herein by reference to Exhibit 10.21 of the Quarterly Report on Form 10-Q for the Quarter Ended September 30, 2000
filed with the Commission on November 13, 2000)                                                                                  





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##### Table of Contents

|        |  |                                                                                                                                                                                                                                                                                                         
|------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|        | 
|10.22   |  | Endo LLC Amended and Restated 1997 Employee Stock Option Plan (incorporated herein by reference to Exhibit 10.22 of the Quarterly Report on Form 10-Q for the Quarter Ended September 30,
2000 filed with the Commission on November 13, 2000)                                                          
|        | 
|10.23   |  | Endo LLC Amended and Restated 1997 Executive Stock Option Plan (incorporated herein by reference to Exhibit 10.23 of the Quarterly Report on Form 10-Q for the Quarter Ended September 30,
2000 filed with the Commission on November 13, 2000)                                                         
|        | 
|10.24   |  | Endo LLC 2000 Amended and Restated Supplemental Employee Stock Option Plan (incorporated herein by reference to Exhibit 10.24 of the Quarterly Report on Form 10-Q for the Quarter Ended
September 30, 2000 filed with the Commission on November 13, 2000)                                             
|        | 
|10.25   |  | Endo LLC 2000 Amended and Restated Supplemental Executive Stock Option Plan (incorporated herein by reference to Exhibit 10.25 of the Quarterly Report on Form 10-Q for the Quarter Ended
September 30, 2000 filed with the Commission on November 13, 2000)                                            
|        | 
|10.26   |  | Amended and Restated Employment Agreement, dated as of December 19, 2007, by and between the Company and Charles A. Rowland, Jr. (incorporated herein by reference to Exhibit 10.29 of the Form
10-K for the year ended December 31, 2007 filed with the Commission on February 26, 2008)               
|        | 
|10.27   |  | Amended and Restated Employment Agreement, dated as of December 19, 2007, by and between the Company and Joyce N. LaViscount (incorporated herein by reference to Exhibit 10.29 of the Form 10-K
for the year ended December 31, 2007 filed with the Commission on February 26, 2008)                   
|        | 
|10.28   |  | Amended and Restated Employment Agreement, dated as of December 19, 2007, by and between the Company and Nancy J. Wysenski (incorporated herein by reference to Exhibit 10.29 of the Form 10-K for
the year ended December 31, 2007 filed with the Commission on February 26, 2008)                     
|        | 
|10.29   |  | Amended and Restated Employment Agreement, dated as of December 19, 2007, by and between the Company and David A. H. Lee (incorporated herein by reference to Exhibit 10.29 of the Form 10-K for
the year ended December 31, 2007 filed with the Commission on February 26, 2008)                       
|        | 
|10.30   |  | [Intentionally Omitted.]                                                                                                                                                                                                                                                                                
|        | 
|10.31   |  | [Intentionally Omitted.]                                                                                                                                                                                                                                                                                
|        | 
|10.32   |  | [Intentionally Omitted.]                                                                                                                                                                                                                                                                                
|        | 
|10.33   |  | [Intentionally Omitted.]                                                                                                                                                                                                                                                                                
|        | 
|10.34   |  | Lease Agreement, dated as of May 5, 2000, by and between Endo Pharmaceuticals and Painters Crossing One Associates, L.P. (incorporated herein by reference to Exhibit 10.34 of the
Registration Statement filed with the Commission on June 9, 2000)                                                   
|        | 
|10.34.1 |  | Amendment to Lease Agreement, dated as of November 6, 2006, by and between Endo Pharmaceuticals and Painters Crossing One Associates, L.P. (incorporated herein by reference to Exhibit 10.34.1 of
the Form 10-Q for the quarter ended September 30, 2006 filed with the Commission on November 9, 2006)
|        | 
|10.35   |  | Amended and Restated Employment Agreement, dated as of December 19, 2007, by and between the Company and Caroline B. Manogue (incorporated herein by reference to Exhibit 10.29 of the Form 10-K
for the year ended December 31, 2007 filed with the Commission on February 26, 2008)                   



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|        |  |                                                                                                                                                                                                                                                                                                                                      
|------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|        | 
|10.36   |  | Amended and Restated Employment Agreement, dated as of December 19, 2007, by and between the Company and Peter A. Lankau (incorporated herein by reference to Exhibit 10.29 of the Form 10-K
for the year ended December 31, 2007 filed with the Commission on February 26, 2008)                                                    
|        | 
|10.36.1 |  | Separation Agreement, dated as of January 28, 2008, Endo Pharmaceuticals Holdings Inc. and Peter A. Lankau (incorporated herein by reference to Exhibit 10.1 of the Current Report on Form 8-K
dated January 30, 2008)                                                                                                               
|        | 
|10.37   |  | Endo Pharmaceuticals Holdings Inc. 2004 Stock Incentive Plan (incorporated herein by reference to Exhibit 10.37 of the Form 10-Q for the Quarter ended June 30, 2004 filed with the
Commission on August 9, 2004)                                                                                                                    
|        | 
|10.38   |  | Endo Pharmaceuticals Holdings Inc. 2007 Stock Incentive Plan (incorporated herein by reference to Exhibit D of the Definitive Proxy Statement on Schedule 14A filed with the Commission on April
30, 2007)                                                                                                                           
|        | 
|10.39   |  | Master Development and Toll Manufacturing Agreement, dated as of May 3, 2001, by and between Novartis Consumer Health, Inc. and Endo Pharmaceuticals (incorporated herein by reference to
Exhibit 10.39 of the Form 10-Q for the Quarter Ended June 30, 2001 filed with the Commission on August 14, 2001)                           
|        | 
|10.39.1 |  | First Amendment, effective February 1, 2003, to the Master Development and Toll Manufacturing Agreement between Endo Pharmaceuticals and Novartis Consumer Health, Inc. (incorporated herein
by reference to Exhibit 10.39.1 of the Form 10-Q for the Quarter Ended June 30, 2005 filed with the Commission on August 8, 2005)       
|        | 
|10.39.2 |  | Second Amendment, effective as of December 1, 2004, to the Master Development and Toll Manufacturing Agreement between Endo Pharmaceuticals and Novartis Consumer Health, Inc. (incorporated
herein by reference to Exhibit 10.39.2 of the Form 10-Q for the Quarter Ended June 30, 2005 filed with the Commission on August 8, 2005)
|        | 
|10.40   |  | Lease Agreement between Painters Crossing Three Associates, L.P. and Endo Pharmaceuticals Inc. dated January 19, 2007 (incorporated herein by reference to Exhibit 10.40 of the Annual
Report on Form 10-K for the Year Ended December 31, 2006 filed with the Commission on March 1, 2007)                                         
|        | 
|10.41   |  | Policy of Endo Pharmaceuticals Holdings Inc. Relating to Insider Trading in Company Securities and Confidentiality of Information (incorporated herein by reference to Exhibit 10.41 of the Form
10-Q for the Quarter ended March 31, 2005 filed with the Commission on May 10, 2005)                                                
|        | 
|10.42   |  | Development, Commercialization and Supply License Agreement, dated as of November 8, 2002, by and between DURECT Corporation and Endo Pharmaceuticals (incorporated herein by reference to
Exhibit 10.42 of the Current Report on Form 8-K dated November 14, 2002)                                                                  
|        | 
|10.42.2 |  | Amendment to Development, Commercialization and Supply License Agreement, dated January 28, 2004, between DURECT Corporation and Endo Pharmaceuticals (incorporated herein by reference to
Exhibit 10.42.2 of the Annual Report on Form 10-K for the Year Ended December 31, 2003 filed with the Commission on March 15, 2004)       
|        | 
|10.42.3 |  | Amendment No. 2 to the Development, Commercialization and Supply License Agreement, dated November 22, 2004, between DURECT Corporation and Endo Pharmaceuticals Inc. (incorporated herein by
reference to Exhibit 10.42.3 of the Current Report on Form 8-K dated November 29, 2004)                                                



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|        |  |                                                                                                                                                                                                                                                                                                                                              
|------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|        | 
|10.42.4 |  | Amendment No. 3 to the Development, Commercialization and Supply License Agreement, dated January 20, 2006, between DURECT Corporation and Endo Pharmaceuticals Inc. (incorporated herein by
reference to Exhibit 10.42.4 of the Current Report on Form 8-K dated January 25, 2006)                                                          
|        | 
|10.42.5 |  | Amendment No. 4 to the Development, Commercialization and Supply License Agreement, dated April 30, 2007, between DURECT Corporation and Endo Pharmaceuticals Inc. (incorporated herein by
reference to Exhibit 10.42.5 of the Form 10-Q for the Quarter Ended March 31, 2007 filed with the Commission on May 10, 2007)                     
|        | 
|10.43   |  | Development and Marketing Strategic Alliance Agreement, dated as of December 31, 2002, by and among Endo Pharmaceuticals, SkyePharma, Inc. and SkyePharma Canada, Inc. (incorporated herein
by reference to Exhibit 10.43 of the Current Report on Form 8-K dated January 8, 2003)                                                           
|        | 
|10.43.1 |  | Agreement to Terminate the Development and Marketing Strategic Alliance Agreement between Endo Pharmaceuticals Inc., SkyePharma, Inc., and Jagotec AG, assignee of SkyePharma Canada, Inc.,
effective February 12, 2007 (incorporated herein by reference to Exhibit 10.43.1 of the Current Report on Form 8-K dated January 16, 2007)       
|        | 
|10.43.2 |  | Amendment to Development and Marketing Strategic Alliance Agreement, dated March 2, 2004, between Endo Pharmaceuticals, SkyePharma, Inc. and SkyePharma Canada, Inc. (incorporated herein by
reference to Exhibit 10.43.2 of the Annual Report on Form 10-K for the Year Ended December 31, 2003 filed with the Commission on March 15, 2004)
|        | 
|10.44   |  | Lease Agreement, dated as of January 6, 2003, by and between Endo Pharmaceuticals and Dawson Holding Company (incorporated herein by reference to Exhibit 10.44 of the Annual Report on Form
10-K for the Year Ended December 31, 2002 filed with the Commission on March 27, 2003)                                                          
|        | 
|10.45   |  | Lease Agreement, dated as of November 13, 2003, by and between Endo Pharmaceuticals and Painters Crossing Two Associates, L.P. (incorporated herein by reference to Exhibit 10.45 of
the Annual Report on Form 10-K for the Year Ended December 31, 2003 filed with the Commission on March 15, 2004)                                       
|        | 
|10.45.1 |  | Amendment to Lease Agreement, dated as of February 16, 2005, by and between Endo Pharmaceuticals and Painters Crossing Two Associates, L.P. (incorporated herein by reference to
Exhibit 10.45.1 of the Current Report on Form 8-K dated February 18, 2005)                                                                                 
|        | 
|10.45.2 |  | Amendment to Lease Agreement, dated as of November 6, 2006, by and between Endo Pharmaceuticals and Painters Crossing Two Associates, L.P. (incorporated herein by reference to Exhibit
10.34.1 of the Form 10-Q for the quarter ended September 30, 2006 filed with the Commission on November 9, 2006)                                     
|        | 
|10.46   |  | License Agreement, dated as of February 25, 2004, by and between Endo Pharmaceuticals and Noven Pharmaceuticals, Inc. (incorporated herein by reference to Exhibit 10.46 of Amendment No. 2
to the Annual Report on Form 10-K for the Year Ended December 31, 2003 filed with the Commission on June 25, 2004)                               
|        | 
|10.46.1 |  | Termination Agreement, dated as of February 24, 2006, by and between Noven Pharmaceuticals, Inc. and Endo Pharmaceuticals (incorporated herein by reference to Exhibit 10.46.1 of the Annual
Report on Form 10-K for the Year Ended December 31, 2005 filed with the Commission on March 8, 2006)                                            



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|        |  |                                                                                                                                                                                                                                                                                                                  
|------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|        | 
|10.47   |  | Supply Agreement, dated as of February 25, 2004, by and between Endo Pharmaceuticals and Noven Pharmaceuticals, Inc. (incorporated herein by reference to Exhibit 10.47 of Amendment No. 2 to
the Annual Report on Form 10-K for the Year Ended December 31, 2003 filed with the Commission on June 25, 2004)    
|        | 
|10.48   |  | License and Co-Promotion Rights Agreement, dated as of July 14, 2004, by and between Endo Pharmaceuticals and Vernalis Development Limited (incorporated herein by reference to Exhibit 10.48
of the Current Report on Form 8-K dated July 19, 2004)                                                             
|        | 
|10.48.1 |  | Co-Promotion Agreement, dated as of July 1, 2005, by and between Endo Pharmaceuticals Inc. and Vernalis Development Limited (incorporated herein by reference to Exhibit 10.48.1 of the
Current Report on Form 8-K dated July 8, 2005)                                                                           
|        | 
|10.48.2 |  | Second Amendment, dated as of December 12, 2005, to the License Agreement by and between Endo Pharmaceuticals Inc. and Vernalis Development Limited (incorporated herein by reference to
Exhibit 10.48.2 of the Current Report on Form 8-K dated December 29, 2005)                                              
|        | 
|10.48.3 |  | First Amendment, dated as of December 12, 2005, to the Co-Promotion Agreement by and between Endo Pharmaceuticals Inc. and Vernalis Development Limited (incorporated herein by reference to
Exhibit 10.48.3 of the Current Report on Form 8-K dated December 29, 2005)                                          
|        | 
|10.48.4 |  | Third Amendment, dated as of July 23, 2007, to the License Agreement by and between Endo Pharmaceuticals Inc. and Vernalis Development Limited (incorporated herein by reference to Exhibit
10.48.4 of the Current Report on Form 8-K dated July 27, 2007)                                                       
|        | 
|10.48.5 |  | Fourth Amendment, dated as of February 19, 2008, to the License Agreement by and between Endo Pharmaceuticals Inc. and Vernalis Development Limited (incorporated herein by reference to Exhibit
10.48.5 of the Form 10-K for the year ended December 31, 2007 filed with the Commission on February 26, 2008)   
|        | 
|10.48.6 |  | Agreement to Terminate the Co-Promotion Agreement by and between Endo Pharmaceuticals Inc. and Vernalis Development Limited, effective February 19, 2008 (incorporated herein by reference to
Exhibit 10.29 of the Form 10-K for the year ended December 31, 2007 filed with the Commission on February 26, 2008)
|        | 
|10.49   |  | Loan Agreement, dated as of July 14, 2004, by and between Endo Pharmaceuticals and Vernalis Development Limited (incorporated herein by reference to Exhibit 10.49 of the Current Report on
Form 8-K dated July 19, 2004)                                                                                        
|        | 
|10.49.1 |  | Agreement to Terminate the Loan Agreement by and between Endo Pharmaceuticals and Vernalis Development Limited, effective February 19, 2008 (incorporated herein by reference to Exhibit 10.29 of
the Form 10-K for the year ended December 31, 2007 filed with the Commission on February 26, 2008)             
|        | 
|21      |  | Subsidiaries of the Registrant (incorporated herein by reference to Exhibit 10.29 of the Form 10-K for the year ended December 31, 2007 filed with the Commission on February 26,
2008)                                                                                                                          
|        | 
|23      |  | Consent of Independent Registered Public Accounting Firm (incorporated herein by reference to Exhibit 10.29 of the Form 10-K for the year ended December 31, 2007 filed with the Commission on
February 26, 2008)                                                                                                



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|     |  |                                                                                                                                                                                                                                                                                     
|---- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|     | 
|24   |  | Power of Attorney (incorporated herein by reference to Exhibit 10.29 of the Form 10-K for the year ended December 31, 2007 filed with the Commission on February 26,
2008)                                                                                                          
|     | 
|31.1 |  | Certification of the President and Chief Executive Officer of Endo pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (incorporated herein by reference to Exhibit 31.1 of the Form 10-K
for the year ended December 31, 2007 filed with the Commission on February 26, 2008)
|     | 
|31.2 |  | Certification of the Chief Financial Officer of Endo pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 (incorporated herein by reference to Exhibit 31.2 of the Form 10-K for the year
ended December 31, 2007 filed with the Commission on February 26, 2008)              
|     | 
|31.3 |  | Certification of the President and Chief Executive Officer of Endo pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                                                                                                                        
|     | 
|31.4 |  | Certification of the Chief Financial Officer of Endo pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                                                                                                                                      
|     | 
|32.1 |  | Certificate of the President and Chief Executive Officer of Endo pursuant to 18 U.S.C Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002                                                                                                            
|     | 
|32.2 |  | Certificate of the Chief Financial Officer of Endo pursuant to 18 U.S.C Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002