Exhibit 10.22

MERCANTILE BANK

LOAN AGREEMENT

THIS LOAN AGREEMENT (the Loan Agreement or Agreement) is made and entered into to be effective as of the 28th day of January,
2009, by and between Mercantile Bank, a division of Carolina First Bank(Lender) and RTI Biologics, Inc., a Delaware corporation (RTI), Tutogen Medical, Inc., a Florida corporation (Tutogen)
and Tutogen Medical (United States), Inc., a Florida corporation (Tutogen US) (Tutogen, collectively with RTI and Tutogen US, the Borrowers).

NOW, THEREFORE, in consideration of the terms and conditions set forth in this Agreement and of Lender making: (i) a term loan to Borrowers of up to
One Million Seven Hundred Fifty Thousand and No/100 Dollars ($1,750,000.00) and (ii) a revolving line of credit in the amount of up to Ten Million and No/100 Dollars ($10,000,000.00), Lender and Borrowers enter into this Loan Agreement and
agree as follows:

1. Definitions. For the purposes hereof:

1.1 Account Debtor means any Person obligated under or on account of any Account.

1.2
Accounts shall have the meaning assigned thereto in the Code.

1.3 Affiliate means, with respect to a named Person,
(a) any Person directly or indirectly owning ten percent (10%) or more of the voting stock or rights in such named Person or of which the named Person owns ten percent (10%) or more of such voting stock or rights; and (b) any
Person controlling or controlled by or under common control with such named Person.

1.4 Borrowing Base means the sum of
(a) 80% of the amount of Borrowers Eligible Accounts, less (b) the amount of any Reserves required by Lender, less (c) the principal amount outstanding under the Term Loan.

1.5 Borrowing Base Certificate means the form attached hereto as Exhibit 1.5.

1.6 Business Day means any day on which Lender is open for business.

1.7 Closing or Closing Date means January 28, 2009.

1.8 Code means the Uniform Commercial Code as in effect under the laws of the State of Florida from time to time, as the same may be amended.

1.9 Collateral shall have meaning assigned thereto in the Security Agreement.



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1.10 Commitment Period means that period during which Lender is obligated to make advances
under the RLOC hereunder, as provided in Section 2.1 hereof. The Commitment Period shall commence upon the satisfaction of the conditions to lending set forth in Section 2.3 hereof, and shall continue until the RLOC Maturity
Date, unless sooner terminated according to the provisions hereof.

1.11 Deposit Accounts shall have the meaning assigned
thereto in the Code.

1.12 Disbursement Account shall have the meaning given in Section 2.1(a)(vii).

1.13 Documents shall have the meaning assigned thereto in the Code.

1.14 Drawings shall have the meaning given in Section 2.1(b).

1.15 EBIDA means the sum of (a) consolidated net income of Borrowers in the applicable fiscal period (computed without regard to any
extraordinary items of gain or loss) plus (b) to the extent deducted from revenue in computing consolidated net income for such period, the sum of (i) interest expense, and (ii) depreciation and amortization.

1.16 Eligible Account means those Accounts of Borrowers arising from the sale of goods or services, which goods or services have actually
been delivered to or provided and accepted by the Account Debtor and payment for such goods and services is owing, less those Accounts which: (i) remain unpaid more than ninety (90) days from the date of the original invoice that
arises in the ordinary course of business; (ii) are disputed or otherwise subject to any return, setoff, credit allowance or adjustment by the Account Debtor; (iii) arise as a result of an Intercompany Transaction; (iv) are Accounts
owing by an Account Debtor that is known to, or believed to be by, Borrowers or Lender not to be Solvent; (v) are Accounts owed by an Account Debtor with its principal place of business outside of the continental United States of America;
(vi) are Accounts owed by the United States of America or any other governmental or quasi-governmental unit, agency or subdivision unless the Borrowers shall have complied with all applicable federal and state assignment of claims laws, and
Borrowers have provided Lender with written evidence satisfactory to Lender of such compliance; (vii) arise between any Borrower and any Affiliate or supplier of such Borrower; (viii) are owed by an Account Debtor with more than thirty
percent (30%) of its original invoices remaining unpaid net of credits approved in writing by Lender more than ninety (90) days from the date of the original invoice; (ix) are subject to any Lien prior to the Lien of the Lender; or
(x) are otherwise unacceptable to Lender exercising good credit judgment and with notice to Borrowers, all of the foregoing being subject to a valid first priority perfected security interest in favor of Lender.

1.17 Environmental Laws shall mean applicable state, federal or local environmental laws or regulations, including but not limited to, the
Comprehensive Environmental Response, Compensation and Liability Act of 1980, as amended by the Superfund Amendments and Reauthorization Act of 1986, 42 U.S.C. § 9601 et seq.; the Emergency Planning and Community Right-to-Know Act, 42 U.S.C.
§ 1101 et seq.; the Solid Waste Disposal Act, as amended by the Resource Conservation and Recovery Act, 42 U.S.C. § 6901 et seq.; the Hazardous Materials Transportation Act of 1974, 49 U.S.C. § 1801
et seq.; the Federal Water Pollution Control Act, 33 U.S.C. § 1251 et seq.; the Clean Air Act, 42 U.S.C. § 7401 et seq.; the Federal Insecticide,



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Fungicide and Rodenticide Act, 7 U.S.C. § 136 et seq.; the Safe Drinking Water Act, 42 U.S.C. § 300f et seq.; the Toxic
Substances Control Act, 15 U.S.C. § 2601 et seq.; the Oil Pollution Act of 1990, 33 U.S.C. § 2701 et seq.; the Endangered Species Act, 16 U.S.C. 1531 et seq.; any laws regulating the use of
biological agents or substances including medical or infectious wastes, each as amended or supplemented, and any applicable and analogous future or present local, state, and federal statutes, regulations, and ordinances promulgated pursuant thereto.

1.18 Event of Default shall have the meaning set forth in Section 6.

1.19 Funded Debt means all outstanding Indebtedness for borrowed money and other interest-bearing Indebtedness, including current and long
term indebtedness.

1.20 Funded Debt to EBIDA Ratio means the ratio of Funded Debt to EBIDA.

1.21 GAAP means generally accepted accounting principles and practices as in effect from time to time and recognized as such by the American
Institute of Certified Public Accountants, consistently applied.

1.22 Indebtedness means, with respect to any Person, without
duplication (a) all indebtedness for borrowed money, (b) all obligations of such Person evidenced by bonds, debentures, notes or similar instruments, or upon which interest payments are customarily made, (c) that portion of
obligations with respect to capital leases that is properly classified as a liability on a balance sheet in conformity with GAAP, (d) all Indebtedness of others secured by (or for which the holder of such Indebtedness has an existing right,
contingent or otherwise to be secured by) any Lien on, or payable out of the proceeds of production from, any property or asset owned, held or acquired by such Person regardless of whether the indebtedness secured thereby shall have been assumed by
that Person or is nonrecourse to the credit of that Person, (e) all guaranty obligations of such Person in respect of any Indebtedness of any other Person and (f) the maximum amount of all standby letters of credit issued or bankers
acceptances facilities created for the account of such Person and, without duplication, all drafts drawn thereunder (to the extent unreimbursed).

1.23 Instrument shall have the meaning assigned thereto in the Code.

1.24 Intercompany Transaction means
any Account, Chattel Paper, General Intangible, Instrument, Document or other Indebtedness or obligation arising from business done with or for, or Indebtedness owed between or among, any Borrower and any Subsidiary or Affiliate thereof.

1.25 Inventory shall have the meaning assigned thereto in the Code.

1.26 Letter of Credit Rights shall have the meaning assigned thereto in the Code.

1.27 Lien means any interest in property (real, personal or mixed, and tangible or intangible) securing an obligation owed to, or a claim by,
a Person other than the owner of the property, whether such interest is based on common law, statute, or contract, and including, but not limited to, the security interest, security title or Lien arising from a security agreement, mortgage, deed of
trust, deed to secure debt, encumbrance, pledge, conditional sale or trust



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receipt or a lease, consignment or bailment for security purposes. For the purpose of this Agreement, a Borrower shall be deemed to be the owner of any
property which it has acquired or holds subject to a conditional sale agreement or other arrangement pursuant to which title of the property has been retained by or vested in some other Person for security purposes.

1.28 Liquidity Ratio means the ratio of Unrestricted Cash to Funded Debt.

1.29 Loan Documents means this Loan Agreement, the Notes, the Security Agreement, any guaranty agreements, financing statements, collateral
documents, consents and all other documents, instruments, certificates and agreements executed and/or delivered by Borrowers, or any third party, in favor of Lender in connection with the Loan or the Lenders security interest in the
Collateral.

1.30 Loans means the Term Loan and the RLOC as each is described in Section 2.1.

1.31 Material Adverse Change means the occurrence of events or circumstances which, if unchanged, would materially impair the Borrowers
(taken as a whole): (i) consolidated financial condition, (ii) ability to meet its financial obligations as they become due, or (iii) ability to conduct its business as presently conducted.

1.32 Notes means the RLOC Note and Term Loan Note.

1.33 Obligations means (a) all principal and/or interest which may be due under the Notes and all other present and future Indebtedness, obligations and liabilities of any Borrower to Lender arising
pursuant to this Agreement and/or any other Loan Document, regardless of whether such Indebtedness, obligations or liabilities are direct, indirect, fixed, contingent, joint or joint and several (including any interest, fees and other charges under
this Agreement or any other Loan Document, which would accrue but for the filing of a bankruptcy or insolvency action, whether or not such claim is allowed in such bankruptcy or insolvency action); (b) all costs incurred by Lender to obtain,
preserve, perfect and enforce the security interest securing payment of such Indebtedness and to maintain, preserve and collect the Collateral, including, but not limited to, taxes, assessments, insurance premiums, repairs, reasonable
attorneys fees and reasonable legal expenses, rent, storage charges, advertising costs, brokerage fees and expenses of sale; (c) all other obligations or liabilities of any Borrower owing to Lender, from time to time, whether now existing
or hereafter arising, regardless of how incurred; and (d) all renewals, extensions and modifications of any of the foregoing, or any part thereof. The term also includes, without limitation, all Indebtedness, liabilities or obligations of any
Borrower which may at any time become due under any rate swap agreement, basis swap, forward rate agreement, commodity swap, commodity option, equity or equity index swap, bond option, interest rate option, foreign exchange agreement, rate cap
agreement, rate floor agreement, rate collar agreement, currency swap agreement, cross-currency swap agreement, currency option or any other similar agreement entered into between Borrower and Lender, or any Affiliate of Lender. The term
Obligations further includes any of the foregoing that arise after the filing of a petition by or against any Borrower under the United States Bankruptcy Code, even if the obligations do not accrue because of the automatic stay under
United States Bankruptcy Code Section 362 or otherwise.



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1.34 Overadvance means an advance by Lender hereunder or under the RLOC Note when an
Overadvance Condition exists or would result from the making of such advance.

1.35 Overadvance Condition means, at any date, a
condition such that the outstanding principal amount of the RLOC on such date exceeds the Borrowing Base on such date.

1.36
Permitted Indebtedness means those matters specified in Section 4.2(g) hereof.

1.37 Permitted Liens
means those Liens specified in Section 4.2(c) hereof.

1.38 Person means an individual person, corporation, limited
liability company, trust, joint venture, limited or general partnership, any government or agency or political subdivision of any government, or any other entity or organization.

1.39 Real Estate shall have the meaning as defined in Section 3.8 hereof.

1.40 Reasonable Cause shall have the meaning as defined in Section 4.1(g) hereof.

1.41 Reserves means such amounts as may be required by Lender at any time and from time-to-time in its reasonable discretion after exercising
good faith credit judgment and after notifying Borrowers. By way of illustration only, such Reserves may be required to address matters affecting the value or quantity of the Borrowing Base which are or were unknown to Lender at Closing or as a
result of any prior inspection or field audit conducted by Lender.

1.42 Restricted Cash means restricted cash as defined by
GAAP.

1.43 RLOC means that certain revolving line of credit in amounts not to exceed Ten Million and No/100 Dollars
($10,000,000.00) as more particularly described in Section 2.1 hereof.

1.44 RLOC Maturity Date means
February 3, 2011.

1.45 RLOC Note means the revolving note of Borrowers in favor of Lender in the amount of the RLOC as
set forth in Section 2.1, as well as any promissory note or notes issued by Borrowers in substitution, replacement, extension, amendment or renewal of any such promissory note or notes.

1.46 Security Agreement means the security agreement given to Lender by Borrowers and covering the Collateral, as more particularly described
in Section 5.1 hereof.

1.47 Solvent means, as to any Person, such Person (i) has assets with value that
exceed its liabilities; (ii) is able to pay all of its Indebtedness as such Indebtedness matures, and (iii) has capital sufficient to carry on its business and transactions and all business and transactions in which it is about to engage.

1.48 Subsidiary means any corporation, partnership or other entity in which any Person, directly or indirectly, owns more than
fifty percent (50%) or more of the stock, capital or other interests (legal or beneficial) which is effectively controlled, directly or indirectly, by such Person.



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1.49 Substances shall have the meaning as defined in Section 3.8 hereof.

1.50 Term Loan means that certain term loan made to Borrowers in the original principal amount of $1,750,000.00 more
particularly described in Section 2.1 hereof.

1.51 Term Maturity Date means February 3, 2011.

1.52 Term Note means the term loan note or borrowing in favor of Lender in the amount of the Term Loan as set forth in
Section 2.1, as well as any promissory note or notes issued by Borrowers in substitution, replacement, extension, amendment or renewal of any such promissory notes or notes.

1.53 Unrestricted Cash means all cash less any Restricted Cash.

2. The Loans and Advances.

2.1 Loans. Lender hereby agrees to make the Loans available to
Borrowers as follows:

(a) RLOC.

(i) Subject to all terms set forth herein but only during the Commitment Period and for so long as no Event of Default has occurred and is continuing, Lender agrees, from time to time and on the terms hereinafter set
forth, to loan to Borrowers, when requested by Borrowers, principal amounts aggregating up to the lesser of (A) Ten Million and No/100 Dollars ($10,000,000.00) or (B) the Borrowing Base as determined by Lender from the periodic
reports submitted by Borrowers to Lender. Within the aforesaid limits, Borrowers may borrow, make payments, and reborrow under this Agreement, subject to the provisions hereof.

(ii) The obligation to repay the RLOC shall be evidenced by the RLOC Note and maturing upon the earlier to occur of acceleration under
Section 7.1 or the RLOC Maturity Date.

(iii) Borrowers shall submit a Borrowing Base Certificate (or in such other form as
may be furnished by Lender from time to time) on the date of this Agreement and at least monthly as set forth in Section 4.1(m) thereafter during the term of this Agreement (or at Lenders request, more frequently following the
occurrence and continuance of an Event of Default and the passage of any applicable cure period). Each such Borrowing Base Certificate shall be signed by a principal financial officer of Borrowers authorized by Borrowers, and acceptable to Lender to
execute such reports, whose name(s) shall be included in a certificate furnished to Lender.



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(iv) As an accommodation to Borrowers, Lender may permit telephonic requests for loans and electronic
transmittal of instructions, authorizations, agreements or reports to Lender by Borrowers. Unless Borrowers specifically direct Lender in writing not to accept or act upon telephonic or electronic communications from Borrowers, Lender shall have no
liability to Borrowers for any loss or damage suffered by Borrowers as a result of Lenders honoring of any requests, execution of any instructions, authorizations or agreements or reliance on any reports communicated to Lender telephonically
or electronically and purporting to have been sent to Lender by Borrowers and Lender shall have no duty to verify the origin of any such communication or the authority of the person sending it. Borrowers shall designate, in writing, named
individuals who are authorized by Borrowers to request advances hereunder, and Lender shall be entitled to rely upon such authorization until revoked in writing by Borrowers.

(v) If the outstanding principal amount of the RLOC at any time exceeds the lesser of Ten Million and No/100 Dollars ($10,000,000.00) or the Borrowing
Base, Borrowers shall promptly on demand pay the Lender an amount equal to such excess as a payment on the principal amount of the RLOC. Without limiting the foregoing, which provision may be enforced by Lender at any time and which provision, as
well as the other provisions hereof, may not under any circumstance be waived or altered by a course of dealing or otherwise, insofar as Borrowers may request and Lender may be willing in its sole and absolute discretion to make Overadvances. All
Overadvances shall be payable on demand, shall be secured by the Collateral and shall bear interest as provided in this Agreement for the RLOC Note. Lender may in its sole discretion honor any request (or deemed request) for an advance even though
an Overadvance Condition then exists, or would exist with the making of such advance, and without regard to the existence of, and without waiving, any default or Event of Default.

(vi) Each borrowing under the RLOC shall be effected by crediting the amount thereof to the regular banking account of Borrowers maintained with the
Lender (Disbursement Account).

(vii) The Borrowers may, upon five (5) Business Days written notice to the Lender,
terminate all or a part of the RLOC; provided, however, that any partial termination of the RLOC shall be in increments of one million dollars ($1,000,000).

(b) Term Loan. Lender hereby agrees to make a term loan in the original principal amount of up to One Million Seven Hundred Fifty Thousand and No/100 Dollars ($1,750,000.00) to Borrowers. The obligation to
repay this Term Loan shall be evidenced by the Term Note and shall have the repayment terms and interest rates as set forth in the Term Note. All amounts outstanding under the Term Note shall be due and payable on the Term Maturity Date. The
proceeds of the Term Loan shall be advanced at closing and be used to satisfy an existing Term Loan from Lender to RTI.

(c) Notice and
Manner of Borrowing. For purposes described under Section 2.2 hereof, Borrowers may present checks and request wire transfers (together Drawings) to be drawn from the Disbursement Account, and to the extent that balances
therein are less than the aggregate amounts of such Drawings to the extent there are funds available, Lender shall advance funds under the RLOC into the Disbursement Account in amounts sufficient to cover



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such Drawings. (PROVIDED HOWEVER, that any request for wire transfers must be presented to Lender not later than 2:00 p.m., Eastern Standard Time on the
Business Day of the requested wire transfer, specifying the date and the amount thereof). Any such notice (including, but not limited to, telephonic notice) which Lender reasonably believes in good faith to have been given by a duly authorized
officer of Borrowers shall be deemed given by Borrowers.

(d) Payments. All sums paid to the Lender by Borrowers hereunder shall be
paid directly to the Lender in immediately available funds no later than 3:00 P.M., Eastern Standard Time on the date on which payment is due, except if such date is not a Business Day such payment shall then be due on the first Business Day after
such date, but interest shall continue to accrue until the date payment is received. Any payment received after 3:00 p.m. Eastern Standard Time shall be deemed to have been received on the immediately following Business Day for all purposes,
including, without limitation, the accrual of interest on principal. Lender shall send Borrowers statements of all amounts due hereunder, which statements shall be considered correct and conclusively binding on the Borrowers unless the Borrowers
notify Lender to the contrary within thirty (30) days of its receipt of any statement which it deems to be incorrect. Lender may, in its sole discretion, (i) charge against any deposit account of any Borrower all or any part of any amount
due hereunder, including, without limitation, interest due under the Notes, and fees and expenses of Lender to be paid by Borrowers as provided for in Section 8.14 of this Agreement, any advances made by Lender to protect the Collateral,
and any commitment or servicing fee due Lender, and (ii) advance to Borrowers, and charge to the RLOC, a sum sufficient each month to pay all interest accrued on the RLOC and fees and expenses due under this Agreement, including, without
limitation, the fees and expenses of Lender to be paid by Borrowers as provided for in Section 8.14 of this Agreement, any advances made by Lender to protect the Collateral, and any commitment or servicing fee due Lender, during or for
the immediately preceding month or any month prior. Borrowers shall be deemed to have requested an advance under the RLOC upon the occurrence of an overdraft in any of Borrowers checking accounts maintained with the Lender.

(e) Application of Payments. Borrowers irrevocably waive the right to direct the application of any and all payments and collections at any time
or times hereafter received by Lender from or on behalf of Borrowers or from any of the Collateral, and Borrowers do hereby irrevocably agree that Lender shall have the continuing exclusive right to apply such payments and collections received at
any time or times hereafter by Lender or its agent against the Obligations which are at the time due and payable, in such manner as Lender may deem advisable, notwithstanding any entry by Lender upon any of its books and records. If as the result of
collections of Accounts or for any other reason, a credit balance exists in the Disbursement Account, such credit balance shall not accrue interest in favor of Borrowers but shall be available to Borrowers at any time or times for so long as no
Event of Default exists.

2.2 Purposes. The proceeds of the RLOC shall be used solely for Borrowers working capital needs and
to satisfy Tutogens obligations to Lender under a line of credit currently outstanding, and the proceeds of the Term Loan shall be used to refinance existing indebtedness of RTI to Lender.

2.3 Conditions Precedent to Advance Loans on Closing Date. Lender shall disburse the proceeds of the Loans to Borrowers in accordance with the
terms hereof, and the terms of the



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Notes. In no event shall Lender be obligated to advance any sum to Borrowers on the Closing Date until all matters, documents, papers and certificates
required hereunder have been furnished to Lenders reasonable satisfaction or so long as any Event of Default has occurred and is continuing. In addition to other matters set forth herein, the following documents and matters shall be required
to be executed or performed by Borrowers at or before the Closing Date (unless as provided otherwise under Section 5 hereof, in connection with the pledge of Collateral):



| | (a) | This Loan Agreement, duly executed and delivered;
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| | (b) | The Notes duly executed and delivered;
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| | (c) | The Collateral documents required under Section 5.1 hereof, and all other Loan Documents, duly executed and delivered;
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| | (d) | Borrowing Resolutions, Secretary Certificate, and Certificate of Incumbency exhibiting, among other things, true copies of each Borrowers current articles of incorporation and
bylaws, in form and substance satisfactory to Lender, authorizing the execution, delivery and performance of all Loan Documents, on behalf of Borrowers;
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| | (e) | Certificate of Existence for RTI from the Delaware Secretary of State and satisfactory evidence of RTIs qualification to do business in any applicable foreign jurisdictions;
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| | (f) | Certificate of Existence for Tutogen from the Florida Secretary of State and satisfactory evidence of Tutogens qualification to do business in any applicable foreign
jurisdictions;
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| | (g) | On or prior to the date of the initial borrowing, Borrowers will provide Lender with an opinion letter, in form and substance satisfactory to Lender, from an attorney acceptable to
Lender. The opinion will provide, to Lenders satisfaction, that the Borrowers are duly organized and validly existing under the laws of the jurisdictions where each Borrower is organized and qualified and has full power and authority to
undertake the activities contemplated by the Loans; that all Loan Documents have been duly authorized, executed and delivered by Borrowers; that, the Loan Documents create a lien on or security interest in the Collateral except when otherwise
specified in the opinion letter; and that the Loan and its terms do not violate any laws including, without limitation, any usury laws or similar laws of the jurisdictions where Borrowers and any Collateral are located, and such other matters and
opinions as Lender reasonably requests. To the extent required by the execution of any Loan Documents provided subsequent to the Closing Date, supplemental opinions may be required of a tenor satisfactory to Lender;
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| | (h) | Reserved;
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| | (i) | Assurances, to the satisfaction of Lender, of Lenders requisite lien position with respect to the Collateral including, but not limited to, Lenders receipt of consents
and waivers from third parties claiming rights in the Collateral under statute, contract or otherwise;
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| | (j) | Payment of all fees and closing costs required hereunder and under the Loan Documents;
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| | (k) | Certificates of insurance required under Section 4.1(e) hereof;
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| | (l) | Lender shall have reasonable assurances that the transactions contemplated hereunder shall not conflict with or constitute a default under any lending agreements between Borrowers
and any third-party lender;
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| | (m) | Borrowers interim financial statements for the monthly period ending closest to the Closing Date;
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| | (n) | Such other financial information with respect to Borrowers as Lender may require; and
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| | (o) | Borrowers shall create a Disbursement Account with Lender; and
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| | (p) | Reserved
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| | (q) | Such other matters as Lender may reasonably require.
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2.4
Conditions Precedent to RLOC Advances. In no event shall Lender be obligated to advance any sum to Borrowers on account of the RLOC until the following conditions shall have been satisfied or waived by the Lender:

(a) Borrowers shall have delivered to Lender a request for an advance under the RLOC in accordance with Section 2.1(a) hereof;

(b) Borrowers shall have delivered to Lender a Borrowing Base Certificate in accordance with Section 2.1(a)(iii) hereof;

(c) The representations and warranties set out in Section 3 hereof shall be true and correct in all material respects on and as of the date
requested for such advance by reference to facts and circumstances existing at such date (except to the extent such representation nor warranty relates to an earlier date, in which case such representation or warranty shall be true and correct in
all material respects as of such earlier date); and

(d) The conditions set forth in Section 2.3 shall have been satisfied or
waived as of the Closing Date.

2.5 Fees.

(a) Borrowers shall pay or cause to be paid, at Closing, all fees and expenses, including, but not limited to, legal fees, and other Lender fees associated with the preparation and execution of this Agreement as well
as all of Lenders fees and expenses associated with financial and Collateral due diligence.

(b) Borrowers shall promptly pay to
Lender any out-of-pocket fees, costs and expenses incurred in connection with collateral audits and inspections.

(c) Borrowers shall pay
or cause to be paid, at Closing, a closing fee, payable to Lender, in the amount of Seventeen Thousand Five Hundred and No/100 Dollars ($17,500.00).

(d) Borrowers shall pay to Lender quarterly, in arrears, an availability fee equal to 0.25% per annum on the average daily unused available principal under the RLOC Note for the preceding calendar quarter or
portion thereof.



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3. Representations and Warranties.

To induce Lender to make and/or continue to make the Loan, each Borrower makes the following representations and warranties, which shall survive the execution and delivery of the Notes and other Loan Documents:

3.1 Good Standing. Each Borrower is duly organized, validly existing, corporation and is in good standing under its state of
incorporation, and has the corporate power and authority to own its property and to carry on its business in each jurisdiction in which it does business, except when the failure to do so would not cause a Material Adverse Change.

3.2 Authority and Compliance. Each Borrower has full power and authority to execute and deliver the Loan Documents and to incur and perform the
Obligations provided for therein, all of which have been duly authorized by all proper and necessary corporate action of Borrowers. To each Borrowers knowledge, no consent or approval of any public authority or other third party is required as
a condition to the validity of any of the Loan Documents, except where the failure to do so would not cause a Material Adverse Change, and each Borrower is in compliance with all laws and regulatory requirements to which it is subject.

3.3 Binding Agreement. This Loan Agreement and the other Loan Documents executed by each Borrower constitute valid and legally binding
obligations of such Borrower, enforceable in accordance with their terms.

3.4 Litigation. There is no proceeding involving any
Borrower pending or, to the knowledge of any Borrower, threatened, before any court or governmental authority, agency or arbitration authority, except as disclosed to Lender on Schedule 3.4 hereto and acknowledged by Lender prior to the date
of this Loan Agreement or (x) in matters in which the damages sought in the aggregate are less than $150,000.00 or (y) otherwise notified to the Lenders after the date of this Loan Agreement.

3.5 No Conflicting Agreements. There is no charter, bylaw, operating agreement, stock provision, partnership agreement or other document
pertaining to the organization, power, or authority of any Borrower and no provision of any existing material agreement, mortgage, indenture or contract binding on any Borrower or affecting its or his properties, in each case, which would conflict
with or in any way prevent the execution, delivery, or carrying out of the terms of this Loan Agreement and the other Loan Documents.

3.6
Ownership of Assets. Each Borrower has good title to its assets, and its assets are free and clear of all judgments, liens, and encumbrances except for Permitted Liens.

3.7 Taxes. All material taxes and assessments due and payable by any Borrower have been paid or are being contested in good faith by appropriate
proceedings and each Borrower has filed all tax returns which it is required to file.

3.8 Compliance with Laws. Each Borrower is in
compliance with all federal, state, and local laws, regulations and governmental requirements applicable to it or to any of its property, business operations, employees, and transactions (including, but not limited to, Environmental Laws, OSHA,
ERISA, Pension Benefit Guaranty Board, and laws regulating wetlands) except to the extent that noncompliance therewith would not cause a Material Adverse Change.



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3.9 Accurate Financial Information. The financial information furnished to Lender is complete and
accurate in all material respects and no Borrower has undisclosed direct or material contingent liabilities. The financial information provided by Borrowers, in connection with Borrowers application to Lender for the Loans, remains
substantially accurate in all material respects and no Material Adverse Change has occurred in the financial condition of any of the reporting entities since such information was furnished.

3.10 Solvency. (i) Borrowers, taken as a whole, are Solvent; (ii) the pledge of the Collateral as contemplated herein to Lender will not
render any Borrower insolvent; (iii) each Borrower has made adequate provision for the payment of all of its creditors other than Lender; and (iv) no Borrower has entered into this transaction to provide preferential treatment to Lender or
any other creditor of any Borrower in anticipation of seeking relief under federal or state bankruptcy or insolvency laws.

3.11
ERISA. No employee benefit plan established or maintained, or to which contributions have been made, by any Borrower, which is subject to Part 3 of Subtitle B of Title I of the Employee Retirement Income Security Act of 1974, as amended
(ERISA), had an accumulated funding deficiency (as such term is defined in Section 302 of ERISA) as of the last day of the most recent fiscal year of such plan ended prior to the date hereof, or would have had such an
accumulated funding deficiency on such day if such year were the first year of such plan to which such Part 3 applied; and no material liability to the Pension Benefit Guaranty Corporation has been incurred with respect to any such plan by such
Person. No Prohibited Transaction or Reportable Event as defined in ERISA has occurred with respect to any employee benefit plan.

Each such employee benefit plan (if any exists) complies and will comply fully with all applicable requirements of ERISA and of the Internal Revenue Code of 1986 as amended (Internal Revenue Code) and with
all applicable rulings and regulations issued under the provisions of ERISA and the Internal Revenue Code. This Loan Agreement and the consummation of the transactions contemplated herein will not involve any prohibited transaction within the scope
of ERISA or Section 4975 of the Internal Revenue Code.

3.12 Subsidiaries. The Subsidiary(ies) of Borrowers are listed on
Schedule 3.12 hereof.

3.13 Place of Business. Each Borrowers chief executive office is located at 11621 Research
Circle, Alachua, Florida 32615 and except as set forth on Schedule 3.13Borrowers have not changed the location of their chief executive office within the last five (5) years. Except as set forth on Schedule 3.13 or as otherwise
in conformance with Section 4.2(b), the Inventory and other Collateral are and shall be located only at such location.

3.14
Name. Except as disclosed on Schedule 3.14, no Borrower has changed its name or been known by any other name within the last five (5) years, nor has it been the surviving the corporation in a merger effected within the last five
(5) years. Borrowers do not use nor have they ever used any trade or fictitious name in the conduct of their business.



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3.15 Inventory. All Inventory has been produced, and during the term hereof will be produced, in
compliance with the requirements of the Federal Fair Labor Standards Act. Inventory is now, nor shall any material portion of Inventory at any time or times hereafter be, consigned or stored with a bailee, warehouseman or similar party without
Lenders prior written consent and, if Lender gives such consent, Borrowers will concurrently therewith cause any such bailee, warehouseman, or similar party to issue and deliver to Lender, in form and substance acceptable to Lender, warehouse
receipts therefor in Lenders name.

3.16 Labor Relations. No Borrower is a party to any collective bargaining agreement, and
there are no material grievances, disputes or controversies with any union or any other organization of Borrowers employees, or threats of strikes, work stoppages or any asserted pending demands for collective bargaining by any union or
organization.

3.17 Trade Relations. There exists no actual or threatened termination, cancellation or limitation of, or any
material adverse modification or Material Adverse Change in, the business relationship between any Borrower and any customer or any group of customers whose purchases individually or in the aggregate are material to the business of Borrowers, taken
as a whole, or with any material supplier, and, to its best knowledge, there exists no present condition or state of facts or circumstances which would materially affect adversely Borrowers, taken as a whole, or prevent Borrowers, taken as a whole,
from conducting such business after the consummation of the transaction contemplated by this Agreement in substantially the same manner in which it has heretofore been conducted.

3.18 Partnerships. No Borrower is a partner or joint venturer with any other Person or a participant in any business enterprise other than its own
for which it is generally liable, nor does any Borrower have any contingent liabilities of any description other than as indicated in the financial statements delivered or to be delivered to Lender.

3.19 Racketeering. No Borrower is engaged in any activity that might constitute a pattern of racketeering activity or in any other conduct that
might subject all or a material portion of Borrowers assets to forfeiture.

4. Covenants of Parties.

4.1 Affirmative Covenants. During the term of this Loan Agreement, Borrowers or each Borrower (as the context requires) will:

(a) Maintenance. Preserve and maintain all licenses, trademarks, privileges, permits, franchises, certificates and the like necessary for the
operation of its businesses in all material respects as conducted on the date of this Loan Agreement.

(b) Financial Statements.
Furnish or cause to be furnished to Lender (i) Borrowers fiscal year-end audited financial statements within ninety (90) days after the close of each fiscal year, prepared on an annual consolidated and consolidating basis; and
(ii) Borrowers internally-prepared monthly financial statements, in a form reasonably satisfactory to



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Lender, within thirty (30) days after the close of each month-end, and certified by the chief financial officer of each Borrower to be true, correct and
complete in all material respects; and (iii) within thirty (30) days of each calendar quarter-end, a certificate of compliance signed by the chief financial officer of each Borrower in the form of Exhibit 4.1(c), affirming
Borrowers continuing compliance with the terms and conditions of this Loan Agreement, which shall include a computation of compliance with all financial covenants as well as the absence of any Event of Default. All financial statements of
Borrowers shall be prepared in accordance with GAAP, shall be in form and content reasonably satisfactory to Lender and shall include, without limitation, balance sheet, profit loss statement, and statement of cash flows.

(c) Tax Returns. Each Borrower shall deliver to the Lender, within thirty (30) days of filing, complete copies of all federal and state tax
returns, as applicable, each of which shall be signed and certified by the Borrowers to be true and complete copies of said returns. In the event an extension is filed, the Borrowers shall deliver a copy of the extension within thirty (30) days
of filing.

(d) Insurance. Maintain with financially sound and reputable insurance companies insurance of the kinds, covering the
risks, and in the amounts reasonably comparable to those usually carried by entities and individuals engaged in businesses similar to that of the Borrowers. Such insurance shall include, but not be limited to, liability insurance, and comprehensive
hazard/casualty insurance on buildings and contents including, but not limited to, such coverage on the Collateral in amounts satisfactory to Lender. Borrowers will exhibit or deliver certificate of such policies of insurance to Lender and provide
appropriate clauses in the insurance policies indicating Lenders status as loss payee as to the Collateral, as its interest may appear. All insurance policies provided hereunder shall be in an amount sufficient to avoid the application of any
co-insurance provisions and must include provisions for a minimum thirty (30) day advance written notice of any intended policy cancellation or non-renewal. Borrowers hereby assign to Lender the right to collect and receive any indemnity
payment otherwise owed to any Borrower under any policy of insurance, on which Lender is named in such policy as a person entitled to collect upon the same. The insurance required hereunder shall be in addition to, and not a replacement for, the
insurance required under any other Loan Documents.

(e) Access to Collateral and Financial Information. During normal business hours
and with reasonable notice, permit any representative or agent of Lender to examine and audit any or all of Borrowers books and records, wherever located, and to have access to all Collateral for purposes of inspection and evaluation.

(f) Notification of Environmental Claims. Except as set forth on Schedule 4.1(f), any hazardous or toxic substance or wastes
(as defined by any Environmental Law), including but not limited to, friable asbestos, PCBs in regulated concentrations, petroleum products, fertilizers and pesticides (Substances) shall be brought upon any real estate owned or leased by
any Borrower (the Real Estate), Borrowers shall maintain and/or remove them in accordance with all applicable laws. Borrowers shall promptly take all action that is needed to abate any material environmental risk or comply with any
Environmental Laws on or related to the Real Estate at its sole expense, subject to such legal and/or equitable defenses available to Borrowers. At Lenders request from time to time, for Reasonable Cause, Borrowers shall obtain additional
environmental audits covering any Real Estate from experts reasonably



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acceptable to Lender. Borrowers will promptly inform Lender in writing of any environmental risk or violation of any Environmental Laws on or related to the
Real Estate or the commencement of any proceeding against it or receipt of any notices by it concerning any alleged violation of Environmental Laws on or related to the Real Estate. Borrowers will permit Lender, or any person or firm designated by
Lender, to inspect the Real Estate on reasonable notice, and will immediately advise Lender in writing of (i) any and all enforcement, cleanup, remedial, removal, or other governmental or regulatory actions instituted, completed, or threatened
pursuant to any applicable federal, state, or local laws, ordinances or regulations relating to any Substances affecting its business operations; and (ii) all claims made or threatened by any third party against it relating to damages,
contributions, cost recovery, compensation, loss or injury resulting from any Substances. Borrowers shall immediately notify Lender of any remedial action taken by it with respect to its business operations. (For purposes hereof, Reasonable
Cause shall be deemed to have occurred at any time that: (i) either Borrower is obligated to provide notice to Lender under this Paragraph 4.1(f), or (ii) either Borrower shall have received notice from any governmental agency
indicating a violation or potential violation of Environmental Laws.)

(g) Environmental Indemnity. Except to the extent caused by
the gross negligence or willful misconduct of Lender or its successors or assigns, Borrowers hereby indemnify and hold Lender harmless from and against all liability, claims, demands, causes of action, losses, damages, costs and expenses (including
reasonable attorneys fees and court costs), including all foreseeable and unforeseeable consequential damages, directly or indirectly arising out of the use, generation, storage, release, or disposal of Substances, including, without
limitation, the cost of any required or necessary inspection, audit, clean-up, or detoxification and the preparation of any closure or other required plans, consent orders, license applications, or the like, whether such action is required or
necessary prior to or following transfer of title of Borrowers real or personal property, to the full extent that such action is attributable, directly or indirectly, to the use, generation, storage, release or disposal of Substances on
Borrowers real or personal property. Borrowers agree that the indemnity obligations in this paragraph shall include indemnifying Lender for all reasonable attorneys fees and expenses incurred by Lender to enforce the terms of this Loan
Agreement. Borrowers indemnity obligations under this paragraph are exclusive of, and in addition to, any other insurance obligations which Borrowers have under this Loan Agreement or any of the Loan Documents. The provisions of this
Section 4.1(h) shall survive the satisfaction or release of all Obligations and shall continue thereafter in full force and effect.

(h) Purpose of Loans. Use the proceeds of the Loans only for the purpose or purposes represented to Lender in Section 2.2.

(i) Notice of Litigation. Promptly, and in any event, no later than fifteen (15) days after being served or otherwise receiving written notice, notify Lender in the event that any legal action is filed
against any Borrower, excepting workers compensation claims and matters for which the damages sought for all outstanding litigation are less than One Hundred Fifty Thousand and No/100 Dollars ($150,000.00) in the aggregate.

(j) Free of Liens. Maintain, at all times, the Collateral free of any Lien or encumbrance other than those expressly permitted by this Loan
Agreement and Permitted Liens.



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(k) Compliance with Law. Comply with all applicable federal, state, and local laws and regulations
including, but not limited to, Environmental Laws, OSHA, ERISA, and the Pension Benefit Guaranty Board, except where non-compliance would not be reasonably expected to cause a Material Adverse Change.

(l) Monthly Reports, etc. Provide to Lender, no later than the fifteenth (15th) day of each month during the term of the RLOC, or from time to time as requested by Lender following the occurrence and continuance of an Event of
Default and the passage of any Cure Period, with such information as Lender shall require including, specifically, (i) a completed Borrowing Base Certificate, (ii) each Borrowers detailed accounts payable and accounts receivable
aging reports including totals, customer names and addresses, reconciliation statements and the original date of each invoice, each certified by the chief financial officer of Borrowers to be true, correct and complete in all material respects.

(m) Payment on Note. Duly and punctually pay all the principal and interest on the Notes, in accordance with the terms of this
Agreement and of the Notes.

(n) Maintenance of Properties. Keep its properties material to the operation of such Borrowers
business in good repair, working order and condition, reasonable wear and tear accepted, and from time to time make all needed and proper repairs, renewals, replacements, additions, and improvements thereto.

(o) Notice to Lender. Immediately notify Lender (i) of any event causing a material loss or material depreciation in the value of the
Collateral and the amount of such loss or depreciation, (ii) if any Borrower becomes aware of the occurrence of any Event of Default or of any fact, condition or event, that would be giving of notice or passage of time, or both, could become an
Event of Default, or (iii) of the occurrence of a Material Adverse Change.

(p) Collection of Accounts. Diligently pursue
collection of all Accounts and other amounts due to any Borrower by others, including Borrowers Affiliates, in a manner consistent with each Borrowers past practices.

(q) Landlord and Storage Agreements. Provide Lender with copies of all agreements between any Borrower and any landlord or warehouseman which owns
any premises at which any material portion of any Inventory or other Collateral may, from time to time, be kept.

(r) Bank Accounts.
Maintain its principal bank accounts with Lender and maintain an average daily balance, tested quarterly, of $5,000,000.00.

4.2
Negative Covenants. During the term of this Loan Agreement, no Borrower will, without prior written consent of Lender:

(a)
Merger/Changes. (i) Enter into any merger, reorganization or consolidation that results in the current shareholders of the applicable Borrowers owning, directly or indirectly, less than 51% of the voting capital of the successor entity;
(ii) change its fiscal year, except as notified by the applicable Borrower to the Lender; or (iii) replace the Chief Executive Officer or Chief Financial Officer with an individual not reasonably satisfactory to the Lender within sixty
(60) days.



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(b) Name; Location of Collateral. Change the locations at which the Collateral is maintained
except for Collateral in transit; change the name, or corporate structure of any Borrower; adopt or make use of any fictitious or tradename not disclosed elsewhere in this Agreement; or change the location of its chief executive office or the state
of its incorporation or organization except in each case as notified by such Borrower to the Lender.

(c) Liens and Security
Interests. Create, incur, assume, or suffer to exist any mortgage, security deed, deed of trust, security interest, pledge, encumbrance, Lien or charge of any kind (including charges on property purchased under conditional sales or other
title-retention agreements) on any of its property or assets, now owned or hereafter acquired, except for the following (all of which are referred to herein as Permitted Liens):

(i) Liens for taxes not yet due or which are being contested in good faith by appropriate proceedings and against which adequate reserves have been set
up (excluding any Lien imposed pursuant to any of the provisions of ERISA);

(ii) Other Liens, charges and encumbrances incidental to the
conduct of its business or the ownership of its property and assets and created by operation of law;

(iii) Purchase money Liens and other
encumbrances created to secure the Indebtedness permitted by Section 4.2(g) hereof; and

(iv) Liens, charges and encumbrances
in favor of the Lender.

(v) Liens arising out of judgments or awards so long as an appeal or proceeding for review is being prosecuted in
good faith and for payment of which adequate reserves, bonds or other security reasonably acceptable to the Lender have been provided or are fully covered by insurance but only to the extent subordinate to Lenders Liens upon the Collateral;
and

(vi) Easements, rights-of-way and similar title exceptions on real property imposed by law or arising in the ordinary course of
business that do not secure any monetary obligations and do not materially detract from the value of the affected property.

(d)
Judgments, etc. Allow any number of judgments for the payment of money in excess of the aggregate sum of Two Hundred Fifty Thousand and No/100 Dollars ($250,000.00) excluding amounts with respect to which an insurance carrier admits full
coverage (except for applicable deductibles), to remain unsatisfied against it for a period of sixty (60) consecutive days, unless execution thereof is stayed.

(e) Sale of Collateral. Sell, transfer, lease, pledge, abandon or otherwise dispose of any material portion of any of the Collateral or any interest therein, provided however that the foregoing prohibition
shall not apply to sales or disposals of Inventory occurring in the ordinary course of business.



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(f) Loans to Others. Excepting loans described to Lender on Schedule 4.2(f) and loans to
and between Borrowers and loans to and between Subsidiaries in an aggregate amount not to exceed $1,000,000.00 at any time, make any material loans, advances, extensions of credit to any other person or entities.

(g) Indebtedness/Guarantees. Except as permitted or contemplated by this Agreement, and otherwise disclosed on Schedule 4.2(g), create,
incur, assume or suffer to exist any Indebtedness or obligation for money borrowed, or guarantee, or endorse, or otherwise be or become contingently liable in connection with the obligations of any Person (including, without limitation, any
Affiliate), except for the following (all of which are referred to herein as Permitted Indebtedness):

(i) Indebtedness secured
by liens expressly permitted by Section 4.2(c)(i) and (iv);

(ii) Indebtedness incurred after the Closing Date consisting of capital
lease obligations or Indebtedness to provide all or a portion of the purchase price or cost of construction of an asset, provided that (i) such Indebtedness when incurred shall not exceed the purchase price or cost of construction of
such assets, (ii) no such Indebtedness shall be refinanced for a principal amount in excess of the principal balance thereon at the time of such refinancing, and (iii) the aggregate amount of all such Indebtedness outstanding at any time
shall not exceed $500,000.00;

(iii) Indebtedness of the Borrowers in respect of hedging agreements entered into in order to manage
existing or anticipated interest rate or exchange rate risks and not for speculative purposes;

(iv) Accounts payable to trade creditors
which are not aged more than one hundred twenty (120) days from billing date and current operating expenses (other than for borrowed money) which are not more than sixty (60) days past due, in each case incurred in the ordinary course of
business and paid within such time period, unless the same are actively being contested in good faith and by appropriate and lawful proceedings and Borrowers shall have set aside such reserves, if any, with respect thereto as have been recommended
by independent public accountants;

(v) Indebtedness for money borrowed from the Lender;

(vi) Indebtedness to other lenders not to exceed at any one time outstanding the principal sum of One Million and No/100 Dollars ($1,000,000.00); and

(vii) Indebtedness of any Borrower to any other Borrower.

(h) Affiliate Transactions. Purchase, acquire or lease property from, or sell, transfer or lease any Inventory, materials, Goods, Equipment, assets or property to, any Affiliate of Borrowers, except in the
ordinary course of Borrowers business and under terms and conditions which would apply if disinterested parties were involved; provided, that nothing herein shall limit (x) any Borrowers ability to make loans or advances to
any other Borrower or to any Subsidiary as permitted by Section 4.2(f) or (y) any Borrowers ability to transfer Inventory between Borrowers and Subsidiaries, consistent with prior practice.



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(i) Financing Statements. Permit any financing statement (except Lenders financing
statements) to be on file with respect to the Collateral.

(j) Acquisitions. Acquire by purchase or otherwise all or substantially
all of the business or assets of, or stock or other evidence of beneficial ownership of, any Person or enter into a joint venture, partnership, or similar arrangement; provided that Borrowers shall be permitted to make such acquisitions or
investments to the extent the cash consideration for such acquisitions or investments does not exceed $5,000,000 in the aggregate in any fiscal year and so long as such action does not cause an Event of Default.

(k) Reserved.

(l) Lease
Transactions. Enter into any sale and lease-back arrangement, either directly or indirectly.

(m) Deposit of Funds. Deposit
proceeds of the Collateral in any depository account other than the Special Collections Account.

(n) Adverse Transactions. Enter
into any transaction, or permit any Subsidiary to enter into any transaction, which materially and adversely affects or may materially and adversely affect the Collateral.

(o) Subsidiary Divestiture. Transfer, sell, pledge, encumber, or otherwise assign any shares of stock or other interest in any Subsidiary or
permit any Subsidiary to sell or otherwise dispose of substantially all of its assets; provided, that nothing herein shall limit any Subsidiarys ability to merge into another Subsidiary or into the Borrower.

(p) Limitation on Debt. Default on any material contract with, or obligation when due to, a third party or default on the performance of any
obligation to a third party incurred from money borrowed in amount in excess, in the aggregate, of $250,000 and permitting such default to continue for a period of more than thirty (30) days.

4.3 Financial Covenants. During the term of this Loan Agreement, Borrowers will maintain the following, all on a consolidated basis:

(a) Liquidity Ratio. At all times, a Liquidity Ratio of not less than 0.50 to 1.00.

(b) Funded Debt to EBIDA Ratio. A ratio of Funded Debt to EBIDA Ratio of not more than 1.35 to 1.00, tested quarterly on a rolling four quarter
basis.

Unless otherwise agreed to by Lender, in writing or as otherwise set forth herein, Borrowers compliance with the foregoing
financial covenants shall be determined in accordance with GAAP, after eliminations for Intercompany Transactions.



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5. Security for the Loans.

5.1 Collateral. Borrowers will execute and deliver or shall have executed and delivered to Lender appropriate security documents, instruments and other agreements in form satisfactory to Lender, granting Lender
a first priority security interest in the Collateral.

5.2 Special Collection Account.

(a) Borrowers shall open a special collection account (the Special Collection Account) with Lender which shall be distinct from the
Disbursement Account, in which all funds received by Borrowers from sales of Inventory, all refunds of taxes, all remittances by Borrowers Account Debtors, all bank wire transfers from a Borrowers Account Debtors, and all other proceeds
of Collateral, shall be deposited no later than the next regular Business Day following receipt thereof. Lender shall have the exclusive right to withdraw or debit funds from the Special Collection Account which may be accomplished by any directive
signed by any authorized representative of Lender. On a daily basis, at the Lenders option, the Collected Balance in the Special Collection Account may be withdrawn by Lender and applied to the RLOC, or, at Lenders discretion, to the
other Loans. If any Borrowing Base Certificate shall show insufficient Borrowing Base to entitle Borrowers to maintain the then current balance owing under the RLOC after applying thereto the Collected Balance of the Special Collection Account, then
Borrowers shall immediately deposit into the Special Collection Account sufficient immediately available funds from which Lender may draw in order to reduce the principal balance of the RLOC to the amount allowable under the provisions of this
Agreement. At the request of Lender, Borrowers shall execute documents provided by Lender to allow officers or authorized representatives of Lender to sign checks drawn on accounts of Borrowers maintained in other banks for the purpose of
transferring funds representing proceeds of Collateral to an account or accounts of Borrowers maintained with Lender, including, without limitation, the Special Collection Account. At its option, Lender may give Borrowers immediate credit for
amounts deposited into the Special Collection Account and charge Borrowers on a monthly basis for interest on the difference between the Ledger Balance and the Collected Balance for the period of time from the date of deposit until the funds are
collected. For purposes of the foregoing, Collected Balance means the book balance in the Special Collection Account less the aggregate amount of all checks and other items of payment in the process of collection, said amount to
be computed in accordance with Lenders standard practices. Ledger Balance means the balance reflected on Lenders books as the amounts deposited in the Special Collection Account. Notwithstanding the foregoing,unless and until an occurrence of an Event of Default, funds deposited in the Special Collection Account shall be transferred into the Borrowers operating and investment account with Lender as the funds are received.

(b) Post Office Box. Borrowers agree to acquire at their expense a post office box in the City of Alachua, Florida, to which Lender and its
designees alone shall have access. Borrowers agree to give notice to all of its Account Debtors to mail payments due to Lender to such post office box. Borrowers agree that Lender, or its designees, may open such post office box, may receive, open
and dispose of all mail addressed to Borrowers at such post office box, and may deposit any payments contained in such mail in the Special Collections Account. Borrowers agree to give all required instructions to the U.S. Postal Service authorities
to enable Lender, or its designees, to attain access to such post office box of Borrowers, agree that they



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will not attempt to remove any mail from such post office box, and agree to execute such additional agreements as Lender may reasonably require in connection
with such post office box. Borrowers agree to instruct all of its Account Debtors which make any payments on the Accounts by bank wire to wire such payments to the Special Collections Account.

(c) Lockbox Agreement. Notwithstanding anything herein to the contrary, to the extent the provisions of this Section 5.2 are inconsistent
with any lockbox agreement or other agreement (Lockbox Agreement) governing the receipt, deposit, and disbursement of moneys received from Accounts or other receivables of Borrowers, the provisions of the Lockbox Agreement shall prevail.

6. Events of Default. The occurrence of any of the following shall constitute an event of default (Event of Default):

6.1 Payment. Any payment of principal, interest, or other sum owed to Lender under the Loan Documents or otherwise due from Borrowers, or any of
them, to Lender is not made when due, whether at stated maturity, upon acceleration, or otherwise.

6.2 Additional Defaults. Any
provision or covenant of any Loan Document is breached, or any warranty, representation, or statement made or furnished to Lender by Borrowers in writing in connection with the Loans and the Loan Documents (including any warranty, representation, or
statement in Borrowers financial statements) or to induce Lender to make the Loans, is untrue or misleading in any material respect.

6.3 Cross-Default-Lender. Any material default by Borrowers, or any of them, or Subsidiary that occurs under any agreement with Lender or an Affiliate of Lender for borrowed money, whether now existing or hereafter arising, which
default is not corrected within the cure period provided in such agreement, if any.

6.4 Dissolution or Bankruptcy. Dissolution or
termination of existence of any Borrower, liquidation, insolvency, business failure, appointment of receiver of any part of the property of, assignment for the benefit of creditors by, or the commencement of any proceeding under state or federal
bankruptcy laws or other insolvency laws by any Borrower or the commencement of an involuntary proceeding against any Borrower under state or federal bankruptcy laws which is not dismissed within ninety (90) days after such commencement, or a
merger or consolidation or sale of any Borrowers assets other than as permitted hereunder.

6.5 Adverse Changes. Any Material
Adverse Change in the condition of any Borrower which Lender reasonably determines will affect the ability of the Borrowers (taken as a whole) to meet their obligations under this Loan Agreement.

6.6 Uninsured Losses; Unauthorized Dispositions. Any material loss, theft, damage or destruction of any material portion of any Collateral not
fully covered by insurance required by this Agreement.

6.7 Business Disruption; Condemnation. There shall occur a cessation of a
substantial part of the business of any Borrower for a period which significantly affects Borrowers capacity (taken as a whole) to continue their businesses; or any Borrower shall suffer



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the loss or revocation of any license or permit now held or hereafter acquired by it which is necessary to the continued or lawful operation of a material
portion of the Borrowers business (taken as a whole); or any Borrower shall be enjoined, restrained or in any way prevented by court, governmental or administrative order from conducting all or any material part of the Borrowers business
affairs (taken as a whole).

6.8 Sale of Assets. The Borrowers shall sell all or substantially all of their assets not in the
ordinary course of business.

6.9 Financing Statements. If for any reason Lenders priority position with respect to the
Collateral ceases to be a fully perfected, first-priority security interest, either by virtue of the filing of a Code financing statement, by virtue of the operation of statute, or otherwise, or if any person shall make any filing altering or
terminating any financing statement of Lender without Lenders prior written consent which is not reinstated or resolved to Lender satisfaction within ten (10) days of the filing thereof.

7. Lenders Remedies. In addition to any remedies available to Lender under the Notes and other Loan Documents, the Lender shall have the following remedies:

7.1 Acceleration. Upon (i) the occurrence of an Event of Default under Section 6.1 hereinabove, which shall remain
uncured after ten (10) days of the occurrence thereof, or (ii) the occurrence of any Event of Default other than an Event of Default under Section 6.1, which shall remain uncured after the lapse of thirty (30) days of the
occurrence thereof (any such period referred to in clause (i) or clause (ii) Cure Period), Lender shall have the option to declare the entire unpaid principal amount of the Loan, accrued interest and all other Obligations
immediately due and payable, without presentment, demand, or notice of any kind, and to terminate any advances under the RLOC.

7.2
Remedies. Upon (i) the occurrence of an Event of Default under Section 6.1 hereinabove, which shall remain uncured after ten (10) days of the occurrence thereof, or (ii) the occurrence of any Event of Default other
than an Event of Default under Section 6.1, which shall remain uncured after the lapse of thirty (30) days of the occurrence thereof, Lender shall be entitled to pursue all rights and remedies available under each of the Loan
Documents, as well as all rights and remedies available at law, or in equity, and such rights and remedies shall be cumulative. Without in any way limiting the generality of the foregoing, Lender shall also have the following non-exclusive rights:

(a) Immediate Possession of Collateral. To take immediate possession of all Collateral, whether now owned or hereafter acquired,
without notice, demand, presentment, or resort to legal process, and, for those purposes, to enter any premises where any of the Collateral is located and remove the Collateral therefrom or render it unusable;

(b) Assembly of Collateral. To require Borrowers to assemble and make the Collateral available to Lender at a place to be designated by Lender
which is also reasonably convenient to Borrowers;

(c) Sale of Personal Property. To retain all non-real estate Collateral in full
or partial satisfaction of any unpaid Obligations as provided in the Code or sell the non-real estate



---

Collateral at public or private sale after giving at least ten (10) days notice of the time and place of the sale, with or without having the
Collateral physically present at the place of the sale (such notice constituting reasonable notice under the Code);

(d) Repair of
Collateral. To make any repairs to the Collateral which Lender deems necessary or desirable for the purposes of sale;

(e)
Set-off. To exercise any and all rights of set-off which Lender may have against any account, fund, or property of any kind, tangible or intangible, belonging to Borrowers which shall be in Lenders possession or under its control;

(f) Cure. To cure any Event of Default in such manner as deemed appropriate by Lender; and

(g) Foreclosure. To foreclose pursuant to the terms of any Loan Document, or at law or in equity.

7.3 Proceeds. The proceeds from any disposition of the Collateral for the Loans shall be used to satisfy the following items in the order they are
listed:

(a) The reasonable expenses of taking, removing, storing, repairing, holding, maintaining and selling the Collateral and otherwise
enforcing the rights of Lender under the Loan Documents, including any reasonable legal costs and reasonable attorneys fees;

(b) The
reasonable expense of liquidating or satisfying any liens, security interests, or encumbrances on the Collateral which may be prior to the security interest of Lender that Lender, at its option, elects to satisfy;

(c) Any unpaid fees, accrued interest and other sums due Lender with respect to Loan Documents, and then the unpaid principal amount of the Loans; and

(d) Any other Obligations.

7.4 Resort to Borrowers. Lender may, at its option, pursue any and all rights and remedies directly against Borrowers, or any one of them, without resort to any Collateral.

7.5 Deficiency. To the extent the proceeds realized from the disposition of the Collateral shall fail to satisfy any of the foregoing items,
Borrowers shall remain liable to pay any deficiency to Lender.

7.6 Advances/Reimbursements. All amounts due Lender as a result of
expenditures made by Lender or losses suffered by Lender, shall bear interest at the rate applicable to past due principal as specified in the Notes or herein from the date demanded until paid in full. Unless otherwise specified in the Loan
Documents, such advances and other sums, together with accrued interest, shall be due and payable on demand.

7.7 Marshalling of Assets;
Payments Set Aside. Lender shall be under no obligation to marshall any assets or securities in favor of Borrowers or any other Person or against or in



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payment of any or all of the Obligations. To the extent that any sum credited against the Obligations is subsequently invalidated, declared to be fraudulent
or preferential, set aside or required to be repaid to a trustee, receiver or any other party under any bankruptcy law, state of federal law, common law or equitable cause, then to the extent of such recovery, the Obligations or such part thereof
originally intended to be satisfied, and all Liens, rights and remedies therefor, shall be revived and continued in full force and effect as if such payment had not been made or such enforcement or set-off had not occurred.

7.8 Default Rate. In addition to any and all other remedies afforded to Lender hereunder, Lender may, in its discretion, impose a default rate
following the occurrence of an Event of Default and the lapse of any cure period applicable thereto in an amount equal to the applicable rate of interest under the Notes plus four percent (4%).

8. Miscellaneous.

8.1 Notice. All notices,
demands, or other communications given under the Loan Documents shall be in writing, and shall be sent via overnight courier, mailed to the address of each party as set forth below (or as set forth in any other Loan Document), or sent via facsimile
to the numbers below said mailing to be certified United States government mail to the mailing address, with notice in each case to be effective when delivered. Any party must provide written direction to the other in order to change the address to
which said notice shall be sent.



|                    |  |                                                                                                                                       
|------------------- |  | --------------------------------------------------------------------------------------------------------------------------------------
|If to Lender, to    |  | Mercantile Bank, a division of Carolina First Bank 600 NW 43rdStreet Gainesville, Florida 32607 Attn: Kip Harrison Fax:
(352) 367-9801
|                    | 
|With copy, to       |  | Nexsen Pruet, LLC P.O. Drawer 10648 Greenville, South Carolina 29601 Attn: David Gossett, Esq. Fax: (864) 282-1177                    
|                    | 
|If to Borrowers, to |  | RTI Biologics, Inc. 11621 Research Circle
Alachua, FL 32615 Attn: Bob Johnston Fax: (386) 462-3821                                    
|                    | 
|With copy, to       |  | Fulbright & Jaworski, LLP 666 Fifth Avenue New York, NY 10103 Attn: Sean Corrigan Fax: (212) 318-3400                                 



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8.2 Waiver. No failure or delay on the part of Lender in exercising any power or right hereunder,
and no failure of Lender to give Borrowers notice of an Event of Default, shall operate as a waiver thereof, nor shall any single or partial exercise of any such right or power preclude any other or further exercise thereof or the exercise of any
other right or power hereunder. No modification or waiver of any provision of any Loan Document or consent to any departure by Borrowers from any Loan Document shall in any event be effective unless the same shall be in writing, signed by Lender and
Borrowers, and such waiver or consent shall be effective only in the specific instance and for the particular purpose for which it was given.

8.3 Benefit. The Loan Documents shall be binding upon and shall inure to the benefit of Borrowers and Lender and their respective successors and assigns.

8.4 Governing Law and Jurisdiction. The Loan Documents and this Loan Agreement, unless otherwise specifically provided therein, and all matters relating thereto, shall be governed by and construed and
interpreted in accordance with the laws of the State of Florida; PROVIDED HOWEVER, to the extent that the creation, validity, perfection, enforceability or priority of any lien or security interest, or the rights and remedies with respect to
any lien or security interest, in the Collateral are governed by the laws of a jurisdiction other than the State of Florida, then the laws of such jurisdiction shall govern, except as superseded by applicable United States Federal Law.

8.5 Assignment. Borrowers may not assign the Loan Documents or any interest therein without Lenders prior written consent.

8.6 Severability. Invalidity of any one or more of the terms, conditions or provisions of this Loan Agreement shall in no way affect the balance
hereof, which shall remain in full force and effect.

8.7 Construction. Whenever the context and construction so require, all words
used in the singular number herein shall be deemed to have been used in the plural, and vice versa, and the masculine gender shall include the feminine and neuter and the neuter shall include the masculine and feminine. All references to Sections
shall mean Sections of the Loan Document. The terms herein, hereinbelow, hereunder, and similar terms are references to the particular Loan Document in its entirety and not merely the particular Article, Section,
or Exhibit in which any such term appears. Captions are inserted only as a matter of convenience and for reference and in no way define, limit or describe the scope of the Loan Document or the intent of any provision thereof. All references to any
Loan Document shall include all amendments, extensions, renewals, restatements or replacements of the same. The terms include, including and similar terms shall be construed as if followed by the phrase without being
limited to and Real Estate and Collateral shall be construed as if followed by the phrase or any part thereof. No inference in favor of any party shall be drawn from the fact that such party has drafted any
portion of the Loan Document. In the event of any inconsistency between the terms of the Loan Agreement and any other Loan Document (with the exception of the Notes), the terms of the Loan Agreement shall control, provided that any provision of any
Loan Document, other than the Loan Agreement, which imposes additional Obligations upon Borrowers or provides additional rights or remedies to Lender shall be deemed to be supplemental to, and not inconsistent with, the Loan Agreement.



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8.8 Execution in Counterparts. All Loan Documents may be executed in two or more counterparts,
each of which shall be deemed to be an original, but all of which shall constitute one and the same instrument, and in making proof of the Loan Document, it shall not be necessary to produce or account for more than one such counterpart.

8.9 Examinations/Communications. Lenders examinations, inspections, or receipt of information pertaining to the matters set forth in the
Loan Documents shall not in any way be deemed to reduce the full scope and protection of the Loan Documents or the Obligations of Borrowers related to the Loan Documents. Borrowers agree that Lender shall have no duty or obligation of any nature to
make any investigation, inspection or review regarding any Collateral at any time, with any such investigation that is undertaken being solely for the benefit of Lender.

8.10 No Third Party Beneficiaries. The Loan Documents are entered into for the sole benefit of Borrowers, their successors and assigns, and no third party shall be deemed to have any privity of contract nor any
right to rely on any Loan Document to any extent or for any purpose whatsoever, nor shall any other person have any right of action of any kind hereof or be deemed to be a party beneficiary.

8.11 No Participation. Nothing in the Loan Documents, and no action or inaction whatsoever on the part of Lender undertaken in connection with the
Loans, shall be deemed to make Lender a partner or joint venturer with Borrowers, and Borrowers indemnify and hold Lender harmless from and against any and all claims, losses, causes of action, expenses (including attorneys fees) and damages
arising from the relationship between Lender and Borrowers being construed as or related to be anything other than that of lender and borrower. This provision shall survive the termination of all Loan Documents.

8.12 Notice of Conduct. Borrowers agree to use commercially reasonable efforts to give Lender written notice of any action or inaction, to the
extent that any Borrower has actual knowledge thereof, by Lender or any agent or attorney of Lender in connection with the Loan Documents or the Obligations of any party under the Loan Documents that Borrowers reasonably believe may be actionable
against Lender or any agent or attorney of Lender or a defense to payment of any Obligations of any Borrower, including commission of a tort or violation of any contractual duty implied by law, and a reasonable opportunity to cure or correct such
action or inaction. Upon request of Lender from time to time, each Borrower shall also confirm in writing the status of the Loans, and the Obligations, and provide other information reasonably requested by Lender.

8.13 Costs, Expenses and Attorneys Fees. Borrowers shall pay to Lender immediately upon demand the full amount of all reasonable
out-of-pocket costs and expenses, including reasonable attorneys fees, costs of experts and all other expenses, incurred by Lender (a) in connection with the negotiation and preparation of this Loan Agreement and each of the other Loan
Documents; (b) upon the occurrence of an Event of Default, or of circumstances which, if left uncured, would result in an Event of Default; (c) the perfection, preservation, protection and continuation of the liens and security interest
granted Lender in the Collateral and the custody, preservation, protection, repair and operation of any of the Collateral, (d) the pursuit by Lender of its rights and remedies under the Loan Documents and applicable law, and (e) defending
any counterclaim, cross-claim or other action, or participating in any bankruptcy proceeding,



---

mediation, arbitration, litigation or dispute resolution of any other nature involving Lender, Borrowers or any Collateral, except to the extent Lender has
been adjudicated to have engaged in culpable conduct.

8.14 Further Assurances. At any time after the date hereof, Borrowers at the
request of Lender, shall execute and deliver such further documents and agreements and take such further actions as Lender reasonably deems necessary or appropriate to permit each transaction contemplated by the Loan Documents to be consummated in
accordance with the provisions thereof and to perfect, preserve, protect and continue all liens, security interests and rights of Lender under the Loan Documents, security agreements, financing statements, continuation statements, new or replacement
Notes, and/or agreements supplementing, extending or otherwise modifying the Notes, this Loan Agreement, and/or any mortgage or security agreement, and certificates as to the amount of the indebtedness evidenced by the Notes.

8.15 Integration. To the extent only of any conflict between the terms of this Loan Agreement and any other Loan Document (other than the Notes),
the terms of this Loan Agreement shall prevail. To the extent only of any conflict between the terms of this Loan Agreement and any of the Notes, the terms of such Notes shall prevail. As provided in Section 5.2, to the extent the
provisions of Section 5.2 are inconsistent with any Lockbox Agreement governing the receipt, deposit, and disbursement of moneys received from Accounts or other receivables of Borrowers, the provisions of the Lockbox Agreement shall
prevail.

8.16 Time of the Essence. Time is of the essence to all Loan Documents.

8.17 USA Patriot Act Notice. The Lender hereby notifies each Borrower that pursuant to the requirements of the USA Patriot Act (Title III of Pub.
L 107-56 (signed into law October 26, 2001)), it is required to obtain, verify and record information that identifies such Borrower, which information includes the name and address of each Borrower, and other information includes the name and
address of each Borrower and other information that will allow the Lender, as applicable, to identify each Borrower in accordance with the U.S. Patriot Act.

8.18 Arbitration. ANY DISPUTE, CONTROVERSY OR CLAIM BETWEEN OR AMONG THE PARTIES HERETO ARISING OUT OF OR RELATING TO (i) THIS INSTRUMENT, AGREEMENT, OR DOCUMENT (ii) OR ANY INSTRUMENT,
AGREEMENT OR DOCUMENT COMPRISING PART OF THE TRANSACTION OR TRANSACTIONS PROVIDED FOR HEREIN, INCLUDING ANY SUCH CLAIM ARISING IN TORT, SHALL BE DETERMINED BY BINDING ARBITRATION IN ACCORDANCE WITH THE FEDERAL ARBITRATION ACT, COMPREHENSIVE
ARBITRATION RULES OF JAMS, AND THE SPECIAL RULES SET FORTH BELOW. IN THE EVENT OF ANY INCONSISTENCY, THE SPECIAL RULES SHALL CONTROL. JUDGMENT UPON ANY ARBITRATION AWARD MAY BE ENTERED IN ANY COURT HAVING JURISDICTION.

A. SPECIAL RULES. THE ARBITRATION SHALL BE CONDUCTED IN GAINESVILLE, FLORIDA AND ADMINISTERED BY JAMS WHO WILL APPOINT AN ARBITRATOR; IF JAMS
IS UNABLE OR LEGALLY PRECLUDED FROM ADMINISTERING THE ARBITRATION, THEN THE AMERICAN ARBITRATION



---

ASSOCIATION (AAA) WILL SERVE AND THE ARBITRATION WILL BE CONDUCTED ACCORDING TO THE FEDERAL ARBITRATION ACT AND THE AAAS COMMERCIAL
ARBITRATION RULES. ALL ARBITRATION HEARINGS WILL BE COMMENCED WITHIN NINETY (90) DAYS OF THE DEMAND FOR ARBITRATION; FURTHER, THE ARBITRATOR SHALL ONLY, UPON A SHOWING OF CAUSE, BE PERMITTED TO EXTEND THE COMMENCEMENT OF SUCH HEARING FOR UP TO
AN ADDITIONAL SIXTY (60) DAYS.

B. RESERVATION OF RIGHTS. NOTHING IN THIS ARBITRATION PROVISION SHALL BE DEEMED TO
(I) LIMIT THE APPLICABILITY OF ANY OTHERWISE APPLICABLE STATUTES OF LIMITATION OR REPOSE AND ANY WAIVERS CONTAINED IN THIS INSTRUMENT, AGREEMENT OR DOCUMENT; OR (II) BE A WAIVER BY LENDER OF THE PROTECTION AFFORDED TO IT BY 12 U.S.C. SEC. 91 OR
ANY SUBSTANTIALLY EQUIVALENT STATE LAW; OR (III) LIMIT ANY RIGHT OF THE LENDER HERETO (A) TO EXERCISE SELF HELP REMEDIES SUCH AS (BUT NOT LIMITED TO) SETOFF, OR (B) TO FORECLOSE AGAINST ANY REAL OR PERSONAL PROPERTY COLLATERAL, OR
(C) TO OBTAIN FROM A COURT PROVISIONAL OR ANCILLARY REMEDIES SUCH AS (BUT NOT LIMITED TO) PRELIMINARY INJUNCTIVE RELIEF, WRIT OF POSSESSION OR THE APPOINTMENT OF A RECEIVER. LENDER MAY EXERCISE SUCH SELF HELP RIGHTS, FORECLOSE UPON SUCH
PROPERTY, OR OBTAIN SUCH PROVISIONAL OR ANCILLARY REMEDIES BEFORE, DURING, OR AFTER THE PENDENCY OF ANY ARBITRATION PROCEEDING BROUGHT PURSUANT TO THIS AGREEMENT EXCEPT THAT LENDER MAY NOT DO SO IN A MANNER INCONSISTENT WITH ANY ARBITRATION AWARD.
NEITHER THIS EXERCISE OF SELF HELP REMEDIES NOR THE INSTITUTION OR MAINTENANCE OF AN ACTION FOR FORECLOSURE OR PROVISIONAL OR ANCILLARY REMEDIES SHALL CONSTITUTE A WAIVER OF THE RIGHT OF ANY PARTY, INCLUDING THE CLAIMANT IN ANY SUCH ACTION, TO
ARBITRATE THE MERITS OF THE CONTROVERSY OR CLAIM OCCASIONING RESORT TO SUCH REMEDIES.

8.19 Multiple Borrowers.

(a) Joint and Several Liability. Each Borrower shall be jointly and severally liable with each other Borrower for the payment and performance of
all of the Obligations; each Borrower shall be deemed to have separately made the representations and warranties set forth herein; each Borrower shall be responsible jointly and severally with the other Borrowers for all of the indemnities set forth
in any of the Loan Documents; each Borrower shall be responsible for discharging the covenants contained in each of the Loan Documents applicable to it; and each Borrower shall be deemed separately to have granted a security interest in its interest
in its types and items of its property constituting Collateral. Lender shall have the right to deal with RTI with regard to all matters concerning the rights and obligations of Lender hereunder and the duties and liabilities of Borrowers hereunder.
All actions or inactions of the officers, managers, members and agents of RTI with regard to the transactions contemplated under any of the Loan Documents shall be deemed to be binding upon all Borrowers hereunder. Any Advances or other extensions
of credit made to one Borrower shall be deemed to have been made to and for



---

the benefit of all Borrowers, it being understood that Borrowers businesses are a mutual and collective enterprise and Borrowers believe that the
consolidation of all Obligations under this Agreement will enhance the aggregate borrowing powers of each Borrower and ease the administration of their loan relationship with Lender, all to the mutual advantage of Borrowers. Each Borrower hereby
appoints each other Borrower as its true and lawful attorney-in-fact, with full right and power, for purposes of exercising all rights of such appointing Borrower hereunder and under applicable law with regard to the transactions contemplated under
the Loan Documents.

(b) Unconditional Nature of Liabilities. Borrowers joint and several liability with respect to the
Obligations shall, to the fullest extent permitted by applicable law, be unconditional irrespective of (i) the validity, enforceability, avoidance or subordination of any of the Obligations or of any document evidencing or securing any part of
the Obligations, (ii) the absence of any attempt to collect any of the Obligations from any other Borrower or any Collateral or other security therefor, or the absence of any other action to enforce the same, (iii) the waiver, consent,
extension, forbearance or granting of any indulgence by Lender with respect to any Loan Documents, (iv) the failure by Lender to take any steps to perfect or maintain the perfected status of its security interest in or Lien upon, or to preserve
its right to, any of the Collateral or Lenders release of any Collateral or its termination or release of any Liens upon any Collateral, (v) the release or compromise, in whole or in part, of the liability of any Borrower for the payment
of any of the Obligations, (vi) any amendment or modification of any of the Loan Documents or any waiver of an Event of Default, (vii) any increase in the amount of the Obligations beyond any limits imposed herein or any increase or
decrease in the amount of any interest, fees or other charges payable in connection therewith, or (viii) any other circumstances that might constitute a legal or equitable discharge or defense of any Borrower. Each Borrower shall be deemed to
have waived any provision under applicable law that might otherwise require Lender to pursue or exhaust its remedies against any Collateral before pursuing such Borrower. Each Borrower consents that Lender shall be under no obligation to marshal any
assets in favor of any Borrower or against or in payment of any or all of the Obligations.

(c) Subordination. Each Borrower
subordinates any claims, including any right of payment, subrogation, contribution and indemnity, that it may have from or against any other Borrower, and any successor or assign of the Borrower, including any trustee, receiver or
debtor-in-possession, howsoever arising, due or owing or whether heretofore, now or hereafter existing, to the full payment of all of the Obligations.

9. Additional Provisions. Riders, schedules and exhibits attached hereto, if any are hereby incorporated into this Loan Agreement as if set forth verbatim.

[SIGNATURE PAGE ATTACHED]



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RTI BIOLOGICS, INC. LOAN AGREEMENT SIGNATURE PAGE

IN WITNESS WHEREOF, the parties hereto have executed this Loan Agreement under seal as of the date first above written.



BORROWERS:RTI Biologics, Inc.By:

/s/ Thomas F. RoseThomas F. Rose, Executive Vice President, Chief Financial Officer and SecretaryTutogen Medical (United States), Inc.By:

/s/ Thomas F. RoseThomas F. Rose, Executive Vice President, Chief Financial Officer and SecretaryTutogen Medical, Inc.By:

/s/ Thomas F. RoseThomas F. Rose, Executive Vice President, Chief Financial Officer and SecretaryLENDER:Mercantile Bank, a division of Carolina First BankBy:

/s/ Kip HarrisonIts:

Senior Vice President




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EXHIBIT 1.5

BORROWING BASE CERTIFICATE FORM



|                |  |                                                                      |       |          |  | 
|--------------- |  | -------------------------------------------------------------------- | ----- | -------- |  | 
|Mercantile Bank |  | LOAN BASE REPORT                                                     |       | Report # |  | 
|                |  |                                                                      |       |          |  | 
|                |  | RTI Biologics, Inc, Tutogen Medical, Inc. Tutogen Medical, Inc. (US) |       | Date     |  | 
|                |  |                                                                      |       |          | 
|                |  |                                                                      | As of |          | 
|                |  |                                                                      |       |          |  | 

|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | - |  | - | ------------- |  | - | - | - |  | - |  | - |  |  | 
|1.     ACCOUNTS
RECEIVABLE                (Line 4 of previous report dated                                                                                            |  |   |  |   |               |  | ) |   |   |  |   |  | $ |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|2.     ADDITIONS TO ACCOUNTS RECEIVABLE                                                                                                                               |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|A.    Gross Sales: Invoices #
 through                                                                                                                                |  | + |  | $ |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|B.     Other Additions (Attach Explanation)                                                                                                                           |  | + |  | $ |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|C.     TOTAL ADDITIONS TO ACCOUNTS RECEIVABLE                                                                                                                         |  |   |  |   |               |  |   |   |   |  | + |  | $ |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|3.     DEDUCTIONS TO ACCOUNTS RECEIVABLE                                                                                                                              |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|A.    Collections                                                                                                                                                     |  | - |  | $ |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|B.     Credit Memos #
 through                                                                                                                                        |  | - |  | $ |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|C.     Discounts Allowed                                                                                                                                              |  | - |  | $ |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|D.    Other Deductions (Attach Explanation)                                                                                                                           |  | - |  | $ |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|E.     TOTAL DEDUCTIONS TO ACCOUNTS RECEIVABLE                                                                                                                        |  |   |  |   |               |  |   |   |   |  | - |  | $ |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |              
|4.     SUB-TOTAL ACCOUNTS RECEIVABLE (Line 1 plus Line 2C minus Line 3E)                                                                                              |  |   |  |   |               |  |   | $ |   |  |  
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|A.    Collections Not Posted to Accounts Receivable (From Page 4)                                                                                                     |  |   |  |   |               |  |   |   |   |  | - |  | $ |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |              
|TOTAL ACCOUNTS RECEIVABLE THIS REPORT (Line 4 minus Line 4A)                                                                                                          |  |   |  |   |               |  |   | $ |   |  |  
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|5.     TOTAL INELIGIBLE ACCOUNTS RECEIVABLE                                                                                                                           |  |   |  |   |               |  |   |   |   |  | - |  | $ |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|(From most recently completed A/Receivable Detail & Ineligibles Report (page
4), as confirmed and accepted by Bank)                                                   |  |   |  |   |               |  |   |   |  
|                                                                                                                                                                      |  |   |  |   |               |  |  
|6.     TOTAL ELIGIBLE ACCOUNTS RECEIVABLE (Line 4 minus Line 5)                                                                                                       |  |   |  |   |               |  |   |   |   |  |   |  | $ |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|7.     ACCOUNTS LOAN VALUE
                ( 80% % of Line 6 )                                                                                                        |  |   |  |   |               |  |   |   |   |  |   |  | $ |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|8.     INVENTORY LOAN VALUE                                                                                                                                           |  |   |  |   |               |  |   |   |   |  |   |  | $ |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|(From most recently submitted Inventory Report (Line 10C), as confirmed and
accepted by Bank)                                                                         |  |   |  |   |               |  |   |   |  
|                                                                                                                                                                      |  |   |  |   |               | 
|9.     OTHER COLLATERAL LOAN VALUE AS APPROVED BY BANK
        Describe:                                                                                              |  |   |  |   |               |  |   |   | + |  | $ |  |   | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|10.   COLLATERAL LOAN VALUE (LINES 7 + 8 + 9)                                                                                                                         |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|11.   Lesser of COLLATERAL LOAN VALUE or LINE OF CREDIT                                                                                                               |  |   |  | $ | 10,000,000.00 |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|NOTE: Line of Credit Note is to fund both revolving and Letter of Credit needs of
client.                                                                             |  |   |  |   |               |  |   |   |   |  |  
|                                                                                                                                                                      |  |   |  |   |               |  |  
|12.   LESS: RESERVES                                                                                                                                                  |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|A.    Letter of Credit Exposure Reserve                                                                                                                               |  |   |  | $ |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|B.     Other MB Loan Outstanding Reserve                                                                                                                              |  |   |  | $ |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|C.     Availability Reserve                                                                                                                                           |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|D.    Total Reserves (Lines 12A + 12B + 12C)                                                                                                                          |  |   |  |   |               |  |   |   |   |  | - |  | $ |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|13.   ADJUSTED COLLATERAL LOAN
VALUE                (Line 11 minus Line 12)                                                                                           |  |   |  |   |               |  |   |   |   |  |   |  | $ |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|14.   LOAN ACCOUNT                                                                                                                                                    |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|A.    Loan Balance Last Loan Base Report                                                                                                                              |  |   |  | $ |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|B.     Less Cash Collected/Paid to Loan Since Last Loan Base Report                                                                                                   |  | - |  | $ |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|C.     Advances Since Last Loan Base Report                                                                                                                           |  | + |  | $ |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|D.    New Loan Balance This Loan Base Report                                                                                                                          |  |   |  | $ |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|15.   LINE OF CREDIT BALANCE THIS REPORT                                                                                                                              |  |   |  |   |               |  |   |   |   |  | - |  | $ |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|16.   TERM LOAN BALANCE THIS REPORT                                                                                                                                   |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |  
|17.   AVAILABILITY / (OVERADVANCED)                                                                                                                                   |  |   |  |   |               |  |   |   |   |  |   |  | $ |  |  | 
|                                                                                                                                                                      |  |   |  |   |               |  |   |   |   |  |   |  |   |  |  | 
|Availability is calculated by subtracting the Line of Credit Balance (Line 15)
and the Term Loan Balance (Line 16) from the Adjusted Collateral Loan Value (Line 13).

In order to secure all existing obligations to Mercantile Bank (Bank), including to but not limited to
all financing contracts, security agreements, loan agreements and promissory notes, together with all modifications or amendments thereto (the Financing Agreements), Borrower hereby assigns, grants and conveys to Bank, its successor and
assigns, a security interest in the above described receivables (Receivables). To the extent appropriate, definitions contained in the Financing Agreements are incorporated herein by reference. Borrower warrants, agrees and represents
the following as a material inducement to the continued extension of credit by Bank:

1. All Receivables made, acquired, created or arising since the last
Loan Base Report (Report) (or if no report, since the first advance of funds was made) are identified and listed above and are more particularly described in and evidenced by schedules of accounts, invoices, delivery receipts, statements
or other written documents furnished, available or to be furnished to satisfactory to Bank. Borrower shall hold in trust for Banks benefit all documents and items which evidence and describe the Receivables including, but not limited to,
copies of al invoices and other items evidencing proof of delivery of goods sold and services rendered. Borrower shall promptly furnish Bank such document sand items a it may from time to time request.

2. This assignment is made in connection with the Financing Agreements. No failure of the Borrower to perform any of the obligations contained herein or therein shall
act to impair or prejudice the rights of the Bank under the Financing Agreements.

3. The total amount of Receivables is shown as of the date of this
Report. All collections received from customers, all allowances and adjustments to customers and all merchandise returned by or repossessed from customers have been reported to Bank. On the date of this Report the proceeds of all Receivables
(including all cash, checks, drafts, acceptances and other forms of payment) have been deposited by Borrower to the credit of Bank and may be evidenced by one or more receipted deposit slips attached hereto.

4. Borrower hereby authorizes and empowers Bank, or such person as Bank may appoint on its behalf; to request any information from account debtors concerning the
Receivables and the amounts owing thereon; to transmit to account debtors notice of the Banks interest therein; to notify account debtors to make the payment directly to Bank; to take all steps deemed by Bank necessary to effect collection of
Receivables (including enforcement by suit and the making of adjustments or compromises as to the debt); and to receive, take, endorse, assign and deliver all checks, notes, drafts and other instruments relating to Receivables.

Borrower hereby appoints and constitutes Bank as Borrowers attorney-in-fact to exercise all of the above powers. Borrower ratifies and approves al acts of Bank,
and holds Bank harmless from any act, omission, error in judgment or mistake of law or fact. This power is irrevocable as long as any Receivable is assigned to Bank or any obligation of Borrower to Bank remains unpaid.

The undersigned certifies that he has read this entire report including its terms, conditions and warranties, whether states above or on other pages and hereby certifies
its correctness and accuracy. The undersigned certifies that the information provided herein, together with all supporting documentation, is true, correct and complete, that all withholding and FICA taxes are paid current as of this date and that
this certification is made pursuant to and in accordance with the Loan Agreement between Borrower and Bank.

|    |  |  |  |  |  |        |  |  |  |  |  |       |  | 
|--- |  |  |  |  |  | ------ |  |  |  |  |  | ----- |  | 
|    |  |  |  |  |  |        | 
|By: |  |  |  |  |  | Title: |  |  |  |  |  | Date: |  | 

Mercantile Bank is a division of Carolina First Bank



---

Mercantile Bank

Loan Base ReportInventory Report

Inventory as
of

Company Name:



|                                    |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  |   |   |      
|----------------------------------- |  | -- | - |  | ------ | -------------------------------------------- | ---------- | - | -------- |  | ----------- |  |  | ------------ |  |  | ------------------- |  | --- |  | - | - | -----
|1. Previous Inventory Balance       |  |    |   |  |        | (Line 10A of previous report dated _______ ) |            |   | $        |  |            
|                                    |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  |   |   |      
|2. Add: New Purchases               |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  | $ |   |      
|                                    |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  |   |   |      
|3. Less: Cost of Goods Sold         |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  | $ |   |      
|                                    |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  |   |   |      
|4. Adjustments (Attach Explanation) |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  | $ |   |      
|                                    |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  |   |   |      
|5. Total Gross Inventory *          |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  | $ | 0 |      
|                                    |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  |   |   |      
|                                    |  |    |   |  |        |                                              |           
|                                    |  |    |   |  | Amount |                                              | Ineligible |   | Eligible |  | AdvanceRate |  |  | InventoryCap |  |  | InventoryLoan Value | 
|6. Raw Materials Inventory          |  |    |   |  | $      |                                              |            |   |          |  | $           |  |  |              |  |  |                     |  |     |  | $ |   |      
|                                    |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  |   |   |      
|7. Work In Process Inventory        |  |    |   |  | $      |                                              |            |   |          |  | $           |  |  |              |  |  |                     |  |     |  | $ |   |      
|                                    |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  |   |   |      
|8. Finished Inventory               |  |    |   |  | $      |                                              |            |   |          |  | $           |  |  |              |  |  |                     |  |     |  | $ |   |      
|                                    |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  |   |   |      
|9. Other Inventory                  |  |    |   |  | $      |                                              |            |   |          |  | $           |  |  |              |  |  |                     |  |     |  | $ |   |      
|                                    |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  |   |   |      
|10. Totals                          |  | (A | ) |  | $      |                                              |            | $ |          |  | $           |  |  |              |  |  | $                   |  | (B) |  | $ |   | (C)**
|                                    |  |    |   |  |        |                                              |            |   |          |  |             |  |  |              |  |  |                     |  |     |  |   |   |      



|* | Total Gross Inventory, if required (Line 5), should equal line 10(A)
|- | --------------------------------------------------------------------

|** | Inventory Loan Value (Line 10C) will be the lessor of 1) the sum of all Eligible Inventory multiplied by its respective Advance Rate or 2) the Inventory Cap.
|-- | -------------------------------------------------------------------------------------------------------------------------------------------------------------

Loan Base ReportA/R Detail & Ineligibles Report



| |  |  |  |        |  |  |  |  |  |  |  |  |  |         |  |  |  | 
| |  |  |  | ------ |  |  |  |  |  |  |  |  |  | ------- |  |  |  | 
| |  |  |  | As of: |  |  |  |  |  |  |  |  |  | ROUNDED |  | 



|            |  |         |  |      |  |       |  |       |  |    
|----------- |  | ------- |  | ---- |  | ----- |  | ----- |  | ---
|Aging Total |  | Current |  | 1-30 |  | 31-60 |  | 61-90 |  | >90
|            |  |         |  |      |  |       |  |       |  |    



|                                                                                       |  | 
|-------------------------------------------------------------------------------------- |  | 
|INELIGIBLE ACCOUNTS                                                                    |  | 
|Balances Over 90 Days from Invoice Date                                                |  | 
|Net Credit Balances >90 Days from Invoice Date                                         |  | 
|Account Debtor Concentrations greater than ____% of Total A/R                          |  | 
|Insiders, Inter-Company or Related Party Accounts                                      |  | 
|Cash/COD Sales                                                                         |  | 
|Accounts Cross-Aged @ 30%                                                              |  | 
|Contra Accounts                                                                        |  | 
|Disputed Accounts                                                                      |  | 
|Foreign Accounts without Bank-Accepted Letter of Credit                                |  | 
|Federal Government Accounts without Assignment of Claims, if required                  |  | 
|State, County, Municipal or other non-Federal Agency Accounts, unless approved by Bank |  | 
|Accounts where Bank's Security Interest is not Perfected                               |  | 
|Accounts with Rejected or Returned Goods                                               |  | 
|Bill & Hold Accounts                                                                   |  | 
|Accounts with Extended or Dated Terms                                                  |  | 
|Accounts based on Consigned Sales                                                      |  | 
|Guaranteed Sale Accounts                                                               |  | 
|Bonded Accounts                                                                        |  | 
|Accounts in Bankruptcy or are Doubtful of Collection based on Borrower Knowledge       |  | 
|Lender Directed Account Debtor Accounts                                                |  | 
|Employee Accounts                                                                      |  | 
|Other AccountsDescribe ___________                                                    |  | 
|Total Ineligible Accounts                                                              |  | 
|                                                                                       | 
|Gross Eligible Accounts                                                                |  | 
|Less: Collections Not Posted To Accounts Receivable                                    |  | 
|Net Eligible Accounts                                                                  |  | 

Mercantile Bank is a division of Carolina First Bank





---

EXHIBIT 4.2(c)

COVENANT COMPLIANCE CERTIFICATE

RTI Biologics, Inc.

Covenant Compliance Certificate



|    |  |                                                                                                                                                                                                                                                                                                                                                           |  |                    |  |               |  |     |  | 
|--- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------------ |  | ------------- |  | --- |  | 
|    |  | For the Period ended:                                                                                                                                                                                                                                                                                                                                     |  |                    |  |               |  |     |  | 
|    |  |                                                                                                                                                                                                                                                                                                                                                           |  |                    |  |               |  |     |  | 
|1.0 |  | Liquidity Ratio: At all times maintain a Liquidity Ratio (Unrestricted Cash to Funded Debt) of not less than .50 to 1.00                                                                                                                                                                                                                                 
|    |  |                                                                                                                                                                                                                                                                                                                                                          
|    |  | Unrestricted Cash                                                                                                                                                                                                                                                                                                                                         |  |                    |  |               |  |     |  | 
|    |  | Funded Debt                                                                                                                                                                                                                                                                                                                                               |  |                    |  |               |  |     |  | 
|    |  | Ratio:                                                                                                                                                                                                                                                                                                                                                    |  |                    |  | In Compliance |  | Yes |  | 
|    |  |                                                                                                                                                                                                                                                                                                                                                           |  |                    |  |               |  | No  |  | 
|    |  |                                                                                                                                                                                                                                                                                                                                                           |  |                    |  |               |  |     |  | 
|2.0 |  | Funded Debt to EBIDA Ratio: Maintain a ratio of Funded Debt to EBIDA of not more than 1.35 to 1.00, tested quarterly on a rolling four quarter basis.                                                                                                                                                                                                    
|    |  |                                                                                                                                                                                                                                                                                                                                                          
|    |  | Funded Debt current:                                                                                                                                                                                                                                                                                                                                      |  |                    |  |               |  |     |  | 
|    |  | EBIDA current qtr:                                                                                                                                                                                                                                                                                                                                        |  |                    |  |               |  |     |  | 
|    |  | EBIDA prior qtr:                                                                                                                                                                                                                                                                                                                                          |  |                    |  |               |  |     |  | 
|    |  | EBIDA prior +1 qtr:                                                                                                                                                                                                                                                                                                                                       |  |                    |  |               |  |     |  | 
|    |  | EBIDA prior + 2 qtr:                                                                                                                                                                                                                                                                                                                                      |  |                    |  |               |  |     |  | 
|    |  | EBIDA total 4 qtrs:                                                                                                                                                                                                                                                                                                                                       |  | $                 |  |               |  |     |  | 
|    |  | Ratio:                                                                                                                                                                                                                                                                                                                                                    |  |                    |  | In Compliance |  | Yes |  | 
|    |  |                                                                                                                                                                                                                                                                                                                                                           |  |                    |  |               |  | No  |  | 
|    |  |                                                                                                                                                                                                                                                                                                                                                           |  |                    |  |               |  |     |  | 
|3.0 |  | Maximum Indebtedness to other lenders not to exceed at any one time outstanding the principal balance of $1,000,000.                                                                                                                                                                                                                                     
|    |  |                                                                                                                                                                                                                                                                                                                                                           |  |                    |  |               |  |     |  | 
|    |  |                                                                                                                                                                                                                                                                                                                                                           |  |                    |  | In Compliance |  | Yes |  | 
|    |  |                                                                                                                                                                                                                                                                                                                                                           |  |                    |  |               |  | No  |  | 
|    |  |                                                                                                                                                                                                                                                                                                                                                           |  |                    |  |               |  |     |  | 
|    |  | I hereby certify that the above statements are true and correct and are calculated as required under terms of the Loan Agreement between Mercantile Bank and RTI Biologics, Inc.,
Tutogen Medical, Inc. and Tutgen Medical, Inc. (US), dated                          , 2009, and that all other terms and
conditions of the agreement are in compliance.
|    |  |                                                                                                                                                                                                                                                                                                                                                          

| |  |         |  |      |  |                     |  |        |  |  |  | 
| |  | ------- |  | ---- |  | ------------------- |  | ------ |  |  |  | 
| |  |         |  |      |  | RTI Biologics, Inc. |  |        |  | 
| |  |         |  |      | 
| |  | Signed: |  |      |  |                     |  | Dated: |  | 
| |  |         |  | its: |  |                     |  |        |  |  |  | 
| |  |         |  |      |  |                     |  |        |  |  |  | 



---

|   |  |                                                                         |  |        |   |  |        |  
|-- |  | ----------------------------------------------------------------------- |  | ------ | - |  | ------ | -
|   |  | EBIDA COVERAGE RATIO PRICING GRID                                       |  |        |   |  |        |  
|   |  | 2009 FY only                                                            |  |        |   |  | Amount |  
|   |  | EBIDA for quarter ended:                                                |  |        |   |  |        |  
|   |  | Quarter Nbr:                                                            |  |        |   |  |        |  
|1  |  | Net Income                                                              |  |        |   |  |        |  
|2  |  | Depreciation                                                            |  |        |   |  |        |  
|3  |  | Amortization                                                            |  |        |   |  |        |  
|4  |  | Interest Expense                                                        |  |        |   |  |        |  
|5  |  | Dividend                                                                |  |        |   |  |        |  
|6  |  | Distributions                                                           |  |        |   |  |        |  
|7  |  | EBIDA                                                                   |  |        |   |  |        |  
|8  |  | Average Quarterly EBIDA                                                 |  |        |   |  |        |  
|9  |  | Numerator (ln 8 x 4) Divided by Principal and Interst Payments for next |  |        |   |  |        |  
|10 |  | four quarters:                                                          |  |        |   |  |        |  
|11 |  | Ratio                                                                   |  |        |   |  |        |  
|   |  |                                                                         | 
|   |  | TABLE EBIDA                                                             |  | MARGIN |   |  |        |  
|   |  | Below 1.25 to 1.00                                                      |  | 3.25   | % |  |        |  
|   |  | From 1.25 to 1.50 to 1.00                                               |  | 3.00   | % |  |        |  
|   |  | From 1.51 to 1.99 to 1.00                                               |  | 2.75   | % |  |        |  
|   |  | Greater than 1.99 to 1.00                                               |  | 2.50   | % |  |        |  
|   |  |                                                                         | 
|   |  | Effective Margin for next qtr:                                          |  |        |   |  | 2.50   | %



---

|   |  |                                                                                      |  |        |   |  |      |   |  |  |  |  |  | 
|-- |  | ------------------------------------------------------------------------------------ |  | ------ | - |  | ---- | - |  |  |  |  |  | 
|   |  | EBIDA COVERAGE RATIO PRICING GRID                                                    |  |        |   |  |      |   |  |  |  |  |  | 
|   |  |                                                                                      |  |        |   |  |      |   |  |  |  |  |  | 
|   |  | Quarter                                                                              |  |        |   |  |      |   |  |  |  |  |  | 
|1  |  | Net Income                                                                           |  |        |   |  |      |   |  |  |  |  |  | 
|2  |  | Depreciation                                                                         |  |        |   |  |      |   |  |  |  |  |  | 
|3  |  | Amortization                                                                         |  |        |   |  |      |   |  |  |  |  |  | 
|4  |  | Interest Expense                                                                     |  |        |   |  |      |   |  |  |  |  |  | 
|5  |  | Dividend                                                                             |  |        |   |  |      |   |  |  |  |  |  | 
|6  |  | Distributions                                                                        |  |        |   |  |      |   |  |  |  |  |  | 
|7  |  | EBIDA                                                                                |  |        |   |  |      |   |  |  |  |  |  | 
|8  |  |                                                                                      |  |        |   |  |      |   |  |  |  |  |  | 
|9  |  | Numerator (sum of ln 7, cols D-G) Divided by Principal and Interst Payments for next |  |        |   |  |      |   |  |  |  |  |  | 
|10 |  | four quarters:                                                                       |  |        |   |  |      |   |  |  |  |  |  | 
|11 |  | Ratio                                                                                |  |        |   |  |      |   |  |  |  |  |  | 
|   |  |                                                                                      |  |        |   | 
|   |  | TABLE EBIDA                                                                          |  | MARGIN |   |  |      |   |  |  |  |  |  | 
|   |  | Below 1.25 to 1.00                                                                   |  | 3.25   | % |  |      |   |  |  |  |  |  | 
|   |  | From 1.25 to 1.50 to 1.00                                                            |  | 3.00   | % |  |      |   |  |  |  |  |  | 
|   |  | From 1.51 to 1.99 to 1.00                                                            |  | 2.75   | % |  |      |   |  |  |  |  |  | 
|   |  | Greater than 1.99 to 1.00                                                            |  | 2.50   | % |  |      |   |  |  |  |  |  | 
|   |  |                                                                                      |  |        |   | 
|   |  | Effective Margin for next qtr:                                                       |  |        |   |  | 2.50 | % |  |  |  |  |  | 



---

SCHEDULE 3.4

LITIGATION



|1. | RTI Biologics, Inc., Plaintiff vs. Michael Evertsen, Defendant
|-- | --------------------------------------------------------------



|2. | CDW Corporation., Plaintiff vs. RTI Biologics, Inc., Defendant
|-- | --------------------------------------------------------------



|3. | Atherlean Grady, individually, as mother of Dixon ,and as Administrtor for the estate of Solomon Grady, Plaintiffs vs. Alabama Organ Center, RTI Biologics, Katilya Williams,
Defendants
|-- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|4. | Larricka Gulley, Plaintiff vs. RTI, Alabama Eye Bank and Andrew Velazquez, MD, Defendants
|-- | -----------------------------------------------------------------------------------------



|5. | Emma King, William King, and Linda Vaughan, Plaintiffs vs. SETA and RTI Defendants
|-- | ----------------------------------------------------------------------------------



|6. | Sheila M. Kirsch & Aavo Kirsch, Plaintiffs vs. James A. Slough, M.D., Western New York Orthopedic Group, Sisters of Charity Hospital, RTI, Upstate New York Transplant
Services, Inc. and Community Blood Center, Defendants
|-- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|7. | Charles V. Lewis and Linda Lewis, Plaintiffs vs. James A. Slough, M.D., Paul J. LaPoint, D.O., Western New York Orthopedic Group, Kenmore Mercy Hospital, RTI, Upstate New York
Transplant Services, Inc. and Community Blood Center, Defendants
|-- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|8. | John Charles Miller vs. Tutogen Medical (U.S.), Inc. and Team Surgical, Inc.
|-- | ----------------------------------------------------------------------------



|9. | Patrick McMahon vs. Tutogen Medical (U.S.), Inc. and Team Surgical, Inc.
|-- | ------------------------------------------------------------------------



|10. | Nilson DeMacena vs. Tutogen Medical (U.S.), Inc. and Team Surgical, Inc.
|--- | ------------------------------------------------------------------------



|11. | Mary Katherine Morris and Carlos D. Morris vs. Blackstone Medical, RTI
|--- | ----------------------------------------------------------------------



|12. | Fredi OSteen., Plaintiff, vs. SETA & RTI., Defendants
|--- | ------------------------------------------------------



|13. | Osteotech, Inc., Plaintiff, vs. Regeneration Technologies, Inc., Defendant, as more particularly described on filings made by the Borrower with the Securities and Exchange
Commission.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|14. | Rita Vinchinsky vs. Anonymous, MD, Anonymous Institute, Anonymous a/k/a Anonymous Hospital, Anonymous MD and Anonymous Technologies, Inc. a/k/a Anonymous Technologies, Inc.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|15. | In Re: Human Tissue Litigation Tissue Recipients vs. Biomedical Tissue Services, et al, as more particularly described on filings made by the Borrower with the Securities and
Exchange Commission.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|16. | In Re: Human Tissue Litigation Donor Families vs. Biomedical Tissue Services, et al, as more particularly described on filings made by the Borrower with the Securities and Exchange
Commission.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



---

SCHEDULE 3.12

SUBSIDIARIES

Subsidiaries of RTI Bioligics, Inc.

Biologic Recovery Group, Inc.

RTI Services, Inc.

Regeneration Technologies, Inc.  Cardiovascular

Tutogen Medical, Inc.

RTI Donor Service, Inc. (controlled)

Subsidiaries of
Tutogen Medical, Inc.

Tutogen Medical (United States), Inc.

Tutogen Medical, GmbH (Germany)

Tutogen Medical, SARL (France) [Subsidiary of Tutogen Medical GmbH]

Subsidiaries of Tutogen Medical (United States), Inc.

None.



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SCHEDULE 3.13

PLACE OF BUSINESS

Previous Locations of Chief Executive Office of Tutogen Medical, Inc. and Tutogen Medical
(United States), Inc.:

From 1/1/2006-2/27/2008:

One
Progress Boulevard

Alachua, Florida 32615

Prior to 1/1/2006:

1130 McBride Avenue,

West Paterson New Jersey 07424



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SCHEDULE 3.14

NAME CHANGE

On 2/27/08, as a result of the merger with Tutogen Medical, Inc., Regeneration
Technologies, Inc. became RTI Biologics, Inc.

SCHEDULE 4.1(F)

HAZARDOUS SUBSTANCES ON REAL ESTATE

Diesel Fuel

Acetone

Human tissues



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SCHEDULE 4.2(f)

LOANS TO OTHERS

None.



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SCHEDULE 4.2(g)

INDEBTEDNESS/GUARANTEES



|                    |  |                 |  |                    |        |              |           
|------------------- |  | --------------- |  | ------------------ | ------ | ------------ | ----------
|Lender              |  | Debt Instrument |  | 12-31-08Amount (1) |        | MaturityDate
|HypoVereinsbank (2) |  | Term Loan       |  | $                  | 374k   |              | 6-30-2011 
|HypoVereinsbank     |  | Term Loan       |  | $                  | 1,145k |              | 3-30-2012 
|HypoVereinsbank     |  | Term Loan       |  | $                  | 1,240k |              | 12-30-2016
|HypoVereinsbank (3) |  | Interim Constr  |  | $                  | 1,224k |              | TBD       
|HypoVereinsbank     |  | Term Loan       |  | $                  | 275k   |              | 9-30-2012 
|HypoVereinsbank     |  | LOC             |  | $                  | 1,442k |              | Revolving 



|(1) | Assumes Euro rate of 1.40970/$1
|--- | -------------------------------

|(2) | HypoVereinsbank debt (up to 4 million euros) guaranteed by Tutogen Medical, Inc. Tutogen Medical, Inc. guaranty in the process of transferring to RTI Biologics, Inc.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(3) | Construction loan in process with build out of GmbH bovine facility. Total loan will be $1,374k by 3/31/09 and will then term out over 5-6 years.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------