# Patent

## Title
Pharmaceutical propylene glycol solvate compositions

## Abstract

The invention relates to pharmaceutical compositions comprising propylene glycol solvates of APIs.

## Background
This application claims the benefit of U.S. Provisional Application No. 60/486,713, filed Jul. 11, 2003, U.S. Provisional Application No. 60/459,501, filed Apr. 1, 2003, U.S. Provisional Application No. 60/456,608, filed Mar. 21, 2003, U.S. Provisional Application No. 60/456,027, filed Mar. 18, 2003, U.S. Provisional Application No. 60/441,335, filed Jan. 21, 2003, and U.S. Provisional Application No. 60/437,516, filed Dec. 30, 2002. The content of each of these applications is hereby incorporated by reference in its entirety.


FIELD OF THE INVENTION
The present invention relates to drug-containing compositions, pharmaceutical compositions comprising such drugs, and methods for preparing same.
BACKGROUND OF THE INVENTION
Drugs in pharmaceutical compositions can be prepared in a variety of different forms. Such drugs can be prepared so as to have a variety of different chemical forms including chemical derivatives or salts. Such drugs can also be prepared to have different physical forms. For example, the drugs may be amorphous or may have different crystalline polymorphs, perhaps existing in different solvation or hydration states. By varying the form of a drug, it is possible to vary the physical properties thereof. For example, crystalline polymorphs typically have different solubilities from one another, such that a more thermodynamically stable polymorph is less soluble than a less thermodynamically stable polymorph. Pharmaceutical polymorphs can also differ in properties such as shelf-life, bioavailability, morphology, vapor pressure, density, color, and compressibility. Accordingly, variation of the solvation state of a drug is one of many ways in which to modulate the physical properties thereof.
A solvate may be defined as a compound formed by solvation, for example as a combination of solvent molecules with molecules or ions of a solute. Well known solvent molecules include water, alcohols and other polar organic solvents. Alcohols include methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, and t-butanol. Alcohols also include polymerized alcohols such as polyalkylene glycols (e.g., polyethylene glycol, polypropylene glycol). The best-known and preferred solvent is typically water, and solvate compounds formed by solvation with water are termed hydrates.
Propylene glycol (1,2-propanediol) is a known substance which is a liquid at ambient temperature. As far as the applicants are aware, propylene glycol is not generally well-known for use in the formation of solvates. U.S. Pat. No. 3,970,651 does disclose the use of propylene glycol in the formation of a crystalline cephalosporin derivative. According to this disclosure a propylene glycolate derivative of a specific cephalosporin zwitterion may be formed in the presence of propylene glycol at acidic pH. This disclosure indicates that the propylene glycol derivative is more stable in solid form than the corresponding ethanolate, especially having excellent colour stability and thermal stability. No other solvates are disclosed in this US patent other than the specific solvate of cephalosporin.
In pharmaceutical formulations certain chemical classes of drugs pose particular problems in preparing pharmaceutical formulations for medical use. One such problem arises in the case of hygroscopic drugs, which tend to absorb water from the air. This is disadvantageous because it makes storage of the drug difficult and can cause degradation of the drug in some cases. Such compounds must be handled in controlled humidity environments during manufacture in order to prevent potency errors due to the changing weight of the drug. The final product must be packaged in individual moisture resistant blisters in order to prevent changes in or degradation of the product. Another problem arises from variable hydration states: molecules may change to a more or less stable form as water, a volatile liquid, is lost. Such changes have been known to cause some hydrates to become amorphous. Likewise, absorption of water by a hygroscopic molecule can plasticize the system and lead to recrystallization as a less stable polymorph.
SUMMARY OF THE INVENTION
Solvates are rarely used in pharmaceuticals because the solvents are usually volatile thus making it difficult to maintain the solvent in the crystal. If one were to desolvate a pharmaceutical solvate or if it desolvated due to storage conditions or otherwise, it could lead to the formation of multiple polymorphs or complete collapse of the crystal structure, forming an amorphous compound with different physical properties. Obviously, this batch-to-batch variability and questionable shelf life is undesired. Typically people find solvates of common solvents, such as propanol and ethanol. Propylene glycol is similar in structure to propanol, but is not thought of as a solvent. Propylene glycol solvates of the present invention desolvate only at considerably higher temperatures and harsher conditions than traditional solvates. Propylene glycol solvates are also pharmaceutically acceptable in much larger amounts than one would expose people to with a traditional solvate. Thus, the propylene glycol solvates of the present invention have characteristics that are vastly superior to traditional solvates.
It has now been found that amorphous, crystalline, hygroscopic, or poorly soluble drugs can be made more soluble, more stable, and less hygroscopic and can be prepared simply, reliably and inexpensively.
In a first aspect, the present invention provides a pharmaceutical composition comprising a propylene glycol solvate of a drug which is hygroscopic or has low aqueous solubility. It has surprisingly been found that by using propylene glycol to form a solvate of a hygroscopic drug, the hygroscopicity of the drug is decreased and/or the stability and aqueous solubility is increased. The drug is therefore much easier to formulate and store than its counterpart untreated or hydrated form.
A number of advantages have been found from the use of propylene glycol in this way. First of all, a higher temperature is required to remove propylene glycol as compared with water or ethanol. This therefore results in an increased thermal stability. Thus the invention further relates to methods of making a pharmaceutical solvate more stable at high temperatures by making a PG solvate of the drug. Secondly, propylene glycol solvates are generally more pharmaceutically acceptable than other common solvates, including those formed from alcohols other than ethanol. It has further been found that the PG solvates of the present invention have fewer solvation states than hydration states. This is beneficial because production and quality of a drug can be more predictable and consistent. Thus an aspect of the present invention relates to methods of reducing the number of hydration states by making a PG solvate of a drug. PG solvates are also beneficial in addressing the problem of polymorphism. Thus an aspect of the present invention relates to methods of reducing the rate and extent a drug changes form and methods of reducing the chance of making an unwanted form because the PG solvates drive production of a single form. Another aspect of the present invention relates to changing the crystal habit of the drug crystal and preventing a drug crystalline habit from changing to a different habit.
The invention relates to making a pharmaceutical that can be made as a hydrate, more soluble or stable by forming a PG solvate of the drug.
The invention further relates to making a pharmaceutical more stable in a humid environment by making a PG solvate of the drug.
The invention further relates to making a crystalline compound from a pharmaceutical that does not readily crystallize by making a crystalline PG solvate of the drug.
The invention further relates to increasing the solubility of a crystalline pharmaceutical by making a PG solvate of the drug.
The invention further relates to methods of lowering the amount of drug solvation during wet granulation by making a PG solvate of the drug.
A particularly important aspect of the present invention is the realization that formation of propylene glycol solvates is applicable in a general way to drugs whereby the above advantages may be conferred. For example, the invention further relates to reducing the level of hygroscopicity of a pharmaceutical metal salt (crystalline, amorphous, solvate (e.g., hydrate)) by forming a PG solvate of the salt. Surprisingly, it has been found that the invention is particularly applicable to those drugs that are in the form of metal salts, such as alkali metal or alkaline earth metal salts. This is especially the case where the metal is selected from sodium, potassium, lithium, calcium and magnesium. Such salts can be hygroscopic and it has hitherto been difficult to find a suitable general means of formulation for these drugs.
Generally, the molar ratio of propylene glycol to drug in the solvate is in the range 0.5 to 2, (e.g., 0.5, 1.0, 1.5, 2.0). Depending on the nature of the drug, the ratio of propylene glycol to drug in the solvate may be approximately 0.25, 0.33, 0.5, 0.67, 0.75, 1.0, 1.5, 2.0 or 3.0.
The composition may further comprise a pharmaceutically-acceptable diluent, excipient or carrier and details of pharmaceutical compositions are also set out in further detail below. The solvate of the pharmaceutical composition according to the present invention is preferably in a crystalline form.
Advantageously, the powder X-ray diffraction (PXRD) spectrum of the composition according to the invention differs from the corresponding powder X-ray diffraction spectrum of unsolvated drug by at least one property selected from:

    
    
        (i) a loss of at least one peak;
        (ii) shifting of more than half the peaks at the 2-theta angle by at least 0.2, 0.3, 0.4, or 0.5 degrees; or
        (iii) formation of at least one new peak.
    
    


It is preferred that the solvate is stable to temperatures of up to 50 degrees C. under a stream of nitrogen gas in a thermogravimetric analysis apparatus.
The PXRD could be the same if their were a host-guest relationship and the PG was not completely frozen out. This would be an inclusion compound rather than a true solvate, but it may still be less hygroscopic than a hydrate, less prone to solvent loss than an inclusion with ethanol, less prone to being filled by some toxic co-solvent if PG fits well, and less prone to polymorphism to a less soluble form due to instability caused by a vacated void in the structure. The DSC transitions are likely to occur at different temperatures and have different intensities than for the parent molecule and it's other hydrates/solvates.
In one aspect of the invention, the drug is a hygroscopic drug, including hygroscopic metal salts. A non-exhaustive list of hygroscopic drugs is set out in Table 1, along with their suppliers and routes of administration.







TABLE 1







Hygroscopic Drugs












Hygro-
Route(s) of


Product (company)
Active ingredient
scopic
Administration





Solu-Medrol (P&U)
Methyl prednisolone
X
Intravenous



succinate ester


Primaxin IV and IM
Imipenem/cilastatin
X
Intravenous/


(Merck)

(cilastatin)
Intramuscular


Vitravene Injection
Fomivirsen sodium
X
Intravenous


(CIBA)


Baycol (Bayer)
Cerivastatin sodium
X
Oral


Synercid IV
Dalfopristin/
X
Intravenous


(Aventis)
Quinopristin


Factrel (Wyeth)
Gonadorelin HCl
X
Intravenous/



(decapeptide)

Subcutaneous


Clindets Pledgets
Clindamycin
X
Topical


(Stiefel)
phosphate (ester



prodrug)


Famvir (SKB)
Famciclovir
X
Oral


Nascobal Gel
Cyanocobalamin
X
Intranasal


(Schwarz)


Tasmar (Roche)
Tolcapone
X
Oral


Ellence Injection
Epirubicin HCl
X
Intravenous


(P&U)


Colestid (P&U)
Colestipol HCl (anion
X
Oral



excluded)


Pfizerpen Injection
Penicillin G
X
Intravenous


(Pfizer)
potassium


Bacitracin Injection
Bacitracin (peptide)
X
Intravenous


(Paddock)


Lescol (Novartis)
Fluvastatin sodium
X
Oral


Voltaren XR
Diclofenac sodium
X
Oral


(Novartis)


Salagen (MGI)
Pilocarpine HCl
X
Oral


Urecholine injection
Bethanechol chloride
X
Intravenous


(Merck)


Syprine (Merck)
Trientine 2(HCl)
X
Oral


Singulair chewable
Montelukast sodium
X
Oral


(Merck)


Mustargen injection
Mechlorethamine HCl
X
Intravenous


(Merck)


Hydrocortone
Hydrocortisone
X
Intravenous


phosphate
phosphate ester


injection (Merck)


Decadron phosphate
Dexamethasone
X
Intravenous


injection (Merck)
phosphate ester


Gastrocrom
Chromolyn sodium
X
Oral


(Medeva)


Mestinon (ICN)
Pyridostigmine
X
Oral



bromide


Adipex-P (Gate)
Phentermine HCl
X
Oral


Micardis
Telmisartan
X
Oral


(Boehringer-


Ingelh.)


Cerubidine injection
Daunorubicin HCl
X
Intravenous


(Bedford)


Biltricide (Bayer)
Praziquantel
X
Oral


Elmiron (Alza)
Pentosan polysulfate
X
Oral



sodium









In one embodiment, the formulation comprises celecoxib. Although the invention is not limited to this particular drug, celecoxib provides a suitable example of the efficacy of the invention. Further details of celecoxib are set out below. In a further embodiment, the drug comprises naproxen, further details of which are also set out below.
In another aspect of the invention, the drug has low aqueous solubility. Typically, low aqueous solubility in the present application refers to a compound having a solubility in water which is less than or equal to 10 mg/ml, when measured at 37 degrees C., and preferably less than or equal to 5 mg/ml or 1 mg/ml. “Low aqueous solubility” can further be defined as less than or equal to 900, 800, 700, 600, 500, 400, 300, 200 150 100, 90, 80, 70, 60, 50, 40, 30, 20 micrograms/ml, or further 10, 5 or 1 micrograms/ml, or further 900, 800, 700, 600, 500, 400, 300, 200 150, 100 90, 80, 70, 60, 50, 40, 30, 20, or 10 ng/ml, or less than 10 ng/ml when measured at 37 degrees C. Aqueous solubility can also be specified as less than 500, 400, 300, 200, 150, 100, 75, 50 or 25 mg/ml. As embodiments of the present invention, solubility can be increased 2, 3, 4, 5, 7, 10, 15, 20, 25, 50, 75, 100, 200, 300, 500, 750, 1000, 5000, or 10,000 times by making a PG solvate of the neutral (crystalline or amorphous), salt, or solvate form (e.g., hydrate, ethanolate, methanolate, isopropanolate, etc.). Further aqueous solubility can be measured in simulated gastric fluid (SGF) rather than water. SGF (non-diluted) of the present invention is made by combining 1 g/L Triton X-100 and 2 g/L NaCl in water and adjusting the pH with 200 mM HCl to obtain a solution with a final pH=1.7.
PG solvates of steroids are also included as embodiments of the present invention. Steroids are an important class of drugs which have low aqueous solubility. Particularly important steroids include acetoxypregnenolone, alclometasone dipropionate, aldosterone, anagestone, norethynodrel, androsterone, betamethasone, budesonide, chlormadinone, chloroprednisone, corticosterone, cortisone, cyclosporine, desogestrel, desoximethasone, desoxycorticosterone, dexamethasone, dichlorisone, dimethisterone, equilenin, equilin, estradiol, estriol, estrogens, estrone, ethisterone, ethynodiol di, ethynyl estradiol, fludrocortisone, fludrocortisone, flunsolide, fluocinolone acetonide, fluorohydrocortisone, fluorometholone, fluoxymesterone, fluprednisolone, flurandrenolide, flurandrenolone, flurogestone, fluticasone propionate, hydrocortisone, hydroxydion, hydroxymethylprogesterone, hydroxyprogesterone, leuprolide, levonorgestrel, loteprednol etabonate, medroxyprogesterone, melengestrol, mesalamine, mestranol, methandrostenolone, methazolamide, methyl testosterone, methylandrostenediol, methylprednisolone, mometasone furoate, norelgestromin, norethandrolone, norethindrone, norethindrone, norethisterone, norgestimate, norgestrel, normethisterone, ondansetron hydrochloride, oxandrolone, oxymetholone, paramethasone, paramethasone, prednisolone, prednisolone, prednisone, pregnenolone, progesterone, prometholone, spironolactone, testosterone, testosterone enanthate, triamcinolone, triamcinolone acetonide, triamcinolone acetonide, vetamethasone disodium phosphate (for some steroids alternative names are included). Formulating steroid drugs presents a problem because of their low aqueous solubility. Embodiments of the present invention are methods of increasing the solubility of steroids by making a PG solvate. Solubility can be specified as discussed above. It is difficult to make crystals of steroids because of their planar structure. Crystallization can be facilitated by making PG solvates. Thus, crystalline PG solvates of steroids and methods of making the same are included in embodiments of the present invention. Steroids generally tend to form non-stoichiometric channel hydrates in which water molecules are trapped in channels between planar steroid regions. Thus, embodiments of the present invention include inhibiting channel formation in steroids by making a PG solvate. Metal salts of steroid drugs can be made and are another example of hygroscopic drugs. Thus, steroid PG solvates are in accordance with one aspect of the present invention. Steroid drugs, whether hygroscopic or not, surprisingly and advantageously form stoichiometric solvates with propylene glycol. Further, the dissolution rate and solubility can be increased with propylene glycol solvates. Thus, the steroid solvates have surprisingly new properties that make them more favourable for pharmaceutical use and are easier to handle than other forms such as hydrates.
In a further aspect, the present invention provides a method for preparing a propylene glycol solvate of a drug, which method comprises:

    
    
        (a) contacting propylene glycol with a drug in solution;
        (b) crystallizing a propylene glycol solvate of the drug from the solution; and
        (c) isolating the solvate. (the drug may be, for example, a hygroscopic drug or a drug of low aqueous solubility).
    
    


In a further aspect, the present invention provides a method for decreasing the hygroscopicity of a drug, which method comprises

    
    
        (a) contacting the drug with propylene glycol in solution;
        (b) crystallizing a propylene glycol solvate of the drug from the solution; and
        (c) isolating the solvate, wherein the solvate has decreased hygroscopicity as compared to the drug.
    
    


In a further aspect, the present invention provides a method for increasing the aqueous solubility of a drug, which method comprises

    
    
        (a) contacting the drug with propylene glycol in solution;
        (b) crystallizing a propylene glycol solvate of the drug from the solution; and
        (c) isolating the solvate, wherein the solvate has increased aqueous solubility as compared to the drug.
    
    


Typically, conditions for making a solvate are the same as for preparing the corresponding non-solvated form of the drug: the solvate of neutral compound would not be pH controlled; the solvate of an acid addition salt would be prepared by including PG with the drug and the acid; and the solvate of a base addition salt would involve adding the drug, the desired base, and the PG. Different co-solvent systems, anti-solvents, or temperature conditions may be used to encourage PG solvate formation. Seed crystals may be added if they have previously been prepared and isolated.
The step of isolating the solvate may include separating the solution phase from the solvate. Any common method of separation may be employed, including filtration and decanting. The crystalline solvate may be rinsed one or more times with an appropriate solvent following filtration or decanting. The crystalline solvate is preferably dried to remove excess solution phase. Drying may be carried out by thermal processing, vacuum, blowing a stream of gas such as air, nitrogen, argon or another inert gas, or a combination of any or all of these methods. The intention of the rinsing and drying steps is to remove impurities including residual co-solvents and excess PG, acid, or base if used.
The invention will now be described in further detail, by way of example only, with reference to the accompanying drawings.



BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 shows a thermogravimetric analysis of a propylene glycol solvate of a celecoxib sodium salt.
FIG. 2A-D shows the PXRD pattern of a propylene glycol solvate of a celecoxib sodium salt.
FIG. 3 shows a thermogravimetric analysis of a propylene glycol solvate of a celecoxib potassium salt.
FIG. 4 shows the PXRD pattern of a propylene glycol solvate of a celecoxib potassium salt.
FIG. 5 shows a thermogravimetric analysis of a propylene glycol solvate of a celecoxib lithium salt.
FIG. 6 shows the PXRD pattern of a propylene glycol solvate of a celecoxib lithium salt.
FIG. 7 shows the thermogravimetric analysis of a propylene glycol solvate of naproxen sodium salt.
FIG. 8 shows a PXRD pattern of a propylene glycol solvate of naproxen sodium salt.
FIG. 9 shows the thermogravimetric analysis of a propylene glycol solvate of olanzapine form I.
FIG. 10 shows the differential scanning calorimetry thermogram of a propylene glycol solvate of olanzapine form I.
FIG. 11A-B shows PXRD patterns of a propylene glycol solvate of olanzapine form I.
FIG. 12 shows a packing diagram of olanzapine form I PG solvate.
FIG. 13 shows the thermogravimetric analysis of a propylene glycol solvate of cortisone acetate.
FIG. 14 shows the differential scanning calorimetry thermogram of a propylene glycol solvate of cortisone acetate.
FIG. 15A-B shows PXRD patterns of a propylene glycol solvate of cortisone acetate.
FIG. 16 shows a PXRD pattern of cortisone acetate.
FIG. 17 shows a packing diagram of cortisone acetate PG solvate.
FIG. 18 shows the thermogravimetric analysis of a trihydrate of celecoxib sodium PG solvate.
FIG. 19 shows the PXRD pattern of a trihydrate of celecoxib sodium PG solvate.
FIG. 20 shows the thermogravimetric analysis of a trihydrate of celecoxib sodium PG solvate.
FIG. 21 shows the PXRD pattern of a trihydrate of celecoxib sodium PG solvate.
FIG. 22 shows the PXRD pattern of celecoxib sodium salt.
FIG. 23 shows the PXRD pattern of celecoxib lithium salt.
FIG. 24 shows the PXRD pattern of celecoxib potassium salt.



DETAILED DESCRIPTION OF THE INVENTION
The present invention relates to propylene glycol solvate forms, preferably stoichiometric, of certain drugs, including those which are hygroscopic or have low aqueous solubility. Whilst the invention is applicable to any such drugs in general, metal salts of the non-steroidal anti-inflammatory drug celecoxib serve to illustrate the present invention by way of example. Unlike traditional non-steroidal anti-inflammatory drugs (NSAIDs), celecoxib is a selective inhibitor of cyclooxygenase II (COX-2) which causes fewer side effects when administered to a subject. The present applicants have identified new forms of celecoxib that have improved properties, particularly as oral formulations. The applicants have found that a stable, crystalline sodium salt of celecoxib can be synthesised which is significantly more soluble in water than the neutral celecoxib on the market. This sodium salt, or other metal salts can subsequently be improved according to the present invention by the production of a propylene glycol solvate thereof.
Salts of celecoxib are formed by reaction of celecoxib with an acceptable base. Acceptable bases include, but are not limited to, metal hydroxides and alkoxides with sufficiently high pKa's (e.g., pKa's greater than about 11 to about 12).
Naproxen is a further API which may be used to illustrate the present invention. Naproxen is a member of the ibufenac group of NSAIDs. This API is practically insoluble in water. Other examples of illustrations of the present invention include olanzapine and cortisone acetate.
An aspect of the present invention provides a pharmaceutical composition comprising a propylene glycol solvate of a drug that is less hygroscopic than the amorphorous, neutral crystalline, or salt crystalline form, and/or has greater aqueous solubility. Hygroscopicity should be assessed by dynamic vapor sorption analysis, in which 5-50 mg of the compound is suspended from a Cahn microbalance. The compound being analyzed should be placed in a non-hygroscopic pan and its weight should be measured relative to an empty pan composed of identical material and having nearly identical size, shape, and weight. Ideally, platinum pans should be used. The pans should be suspended in a chamber through which a gas, such as air or nitrogen, having a controlled and known percent relative humidity (% RH) is flowed until eqilibrium criteria are met. Typical equilibrium criteria include weight changes of less than 0.01% change over 3 minutes at constant humidity and temperature. The relative humidity should be measured for samples dried under dry nitrogen to constant weight (<0.01% change in 3 minutes) at 40 degrees C. unless doing so would de-solvate or otherwise convert the material to an amorphous compound. In one aspect, the hygroscopicity of a dried compound can be assessed by increasing the RH from 5 to 95% in increments of 5% RH and then decreasing the RH from 95 to 5% in 5% increments to generate a moisture sorption isotherm. The sample weight should be allowed to equilibrate between each change in % RH. If the compound deliquesces or becomes amorphous between above 75% RH, but below 95% RH, the experiment should be repeated with a fresh sample and the relative humidity range for the cycling should be narrowed to 5-75% RH or 10-75% RH instead of 5-95% RH. If the sample cannot be dried prior to testing due to lack of form stability, than the sample should be studied using two complete humidity cycles of either 10-75% RH or 5-95% RH, and the results of the second cycle should be used if there is significant weight loss at the end of the first cycle.
Hygroscopicity can be defined using various parameters. For purposes of the present invention, a non-hygroscopic molecule should not gain or lose more than 1.0%, or more preferably, 0.5% weight at 25 degrees C. when cycled between 10 and 75% RH (relative humidity at 25 degrees C.). The non-hygroscopic molecule more preferably should not gain or lose more than 1.0%, or more preferably, 0.5% weight when cycled between 5 and 95% RH at 25 degrees C., or more than 0.25% of its weight between 10 and 75% RH. Most preferably, a non-hygroscopic molecule will not gain or lose more than 0.25% of its weight when cycled between 5 and 95% RH.
Alternatively, for purposes of the present invention, hygroscopicity can be defined using the parameters of Callaghan et al., Equilibrium moisture content of pharmaceutical excipients, in Drug Dev. Ind. Pharm., Vol. 8, pp. 335-369 (1982). Callaghan et al. classified the degree of hygroscopicity into four classes.













Class 1: Non-hygroscopic
Essentially no moisture increases occur



at relative humidities below 90%.


Class 2: Slightly hygroscopic
Essentially no moisture increases occur



at relative humidities below 80%.


Class 3: Moderately hygroscopic
Moisture content does not increase more



than 5% after storage for 1 week at



relative humidities below 60%.


Class 4: Very hygroscopic
Moisture content increase may occur at



relative humidities as low as 40 to 50%.









Alternatively, for purposes of the present invention, hygroscopicity can be defined using the parameters of the European Pharmacopoeia Technical Guide (1999, p. 86) which has defined hygrospocity, based on the static method, after storage at 25 degrees C. for 24 h at 80% RH:

    
    
        Slightly hygroscopic: Increase in mass is less than 2 percent m/m and equal to or greater than 0.2 percent m/m.
        Hygroscopic: Increase in mass is less than 15 percent m/m and equal to or greater than 0.2 percent m/m.
        Very hygroscopic: Increase in mass is equal to or greater than 15 percent m/m.
        Deliquescent: Sufficient water is absorbed to form a liquid.
    
    


PG solvates of the present invention can be set forth as being in Class 1, Class 2, or Class 3, or as being Slightly hygroscopic, Hygroscopic, or Very hygroscopic. PG solvates of the present invention can also be set forth based on their ability to reduce hygroscopicity. Thus, preferred PG solvates of the present invention are less hygroscopic than the non-PG solvated reference compound, e.g., the reference compound of a celecoxib sodium salt PG solvate is celecoxib sodium salt. Further included in the present invention are PG solvates that do not gain or lose more than 1.0% weight at 25 degrees C. when cycled between 10 and 75% RH, wherein the reference compound gains or loses more than 1.0% weight under the same conditions. Further included in the present invention are PG solvates that do not gain or lose more than 0.5% weight at 25 degrees C. when cycled between 10 and 75% RH, wherein the reference compound gains or loses more than 0.5% or more than 1.0% weight under the same conditions. Further included in the present invention are PG solvates that do not gain or lose more than 1.0% weight at 25 degrees C. when cycled between 5 and 95% RH, wherein the reference compound gains or loses more than 1.0% weight under the same conditions. Further included in the present invention are PG solvates that do not gain or lose more than 0.5% weight at 25 degrees C. when cycled between 5 and 95% RH, wherein the reference compound gains or loses more than 0.5% or more than 1.0% weight under the same conditions. Further included in the present invention are PG solvates that do not gain or lose more than 0.25% weight at 25 degrees C. when cycled between 5 and 95% RH, wherein the reference compound gains or loses more than 0.5% or more than 1.0% weight under the same conditions.
Further included in the present invention are PG solvates that have a hygroscopicity (according to Callaghan et al.) that is at least one class lower than the reference compound or at least two classes lower than the reference compound. Non-limiting examples include; a Class 1 PG solvate of a Class 2 reference compound, a Class 2 PG solvate of a Class 3 reference compound, a Class 3 PG solvate of a Class 4 reference compound, a Class 1 PG solvate of a Class 3 reference compound, a Class 1 PG solvate of a Class 4 reference compound, or a Class 2 PG solvate of a Class 4 reference compound.
Further included in the present invention are PG solvates that have a hygroscopicity (according to the European Pharmacopoeia Technical Guide) that is at least one class lower than the reference compound or at least two classes lower than the reference compound. Non-limiting examples include; a Slightly hygroscopic PG solvate of a Hygroscopic reference compound, a Hygroscopic PG solvate of a Very Hygroscopic reference compound, a Very Hygroscopic PG solvate of a Deliquescent reference compound, a Slightly hygroscopic PG solvate of a Very Hygroscopic reference compound, a Slightly hygroscopic PG solvate of a Deliquescent reference compound, a Hygroscopic PG solvate of a Deliquescent reference compound.
In another aspect of the present invention, the dissolution profile of the API (active pharmaceutical ingredient) (e.g. celecoxib) is modulated whereby the aqueous dissolution rate or the dissolution rate in simulated gastric fluid (SGF) or in simulated intestinal fluid (SIF), or in a solvent or plurality of solvents is increased. Dissolution rate is the rate at which API solids dissolve in a dissolution medium. For APIs whose absorption rates are faster than the dissolution rates (e.g., steroids), the rate-limiting step in the absorption process is often the dissolution rate. Because of a limited residence time at the absorption site, APIs that are not dissolved before they are removed from the intestinal absorption site are considered useless. Therefore, the rate of dissolution has a major impact on the performance of APIs that are poorly soluble. Because of this factor, the dissolution rate of APIs in solid dosage forms is an important, routine, quality control parameter used in the API manufacturing process.

Dissolution rate=K S(Cs−C)  (1)

where K is dissolution rate constant, S is the surface area, Cs is the apparent solubility, and C is the concentration of API in the dissolution media. For rapid API absorption, Cs−C is approximately equal to Cs. The dissolution rate of APIs may be measured by conventional means known in the art.

The increase in the dissolution rate of a composition of the present invention, as compared to the unsolvated form, may be specified, such as by 10, 20, 30, 40, 50, 60, 70, 80, 90, or 100%, or by 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 40, 50, 75, 100, 125, 150, 175, 200, 250, 300, 350, 400, 500, 1000, 10,000, or 100,000 fold greater than the unsolvated form in the same solution. Conditions under which the dissolution rate is measured are discussed above. The increase in dissolution may be further specified by the time the composition remains supersaturated. Examples of above embodiments include: compositions with a dissolution rate, at 37 degrees C. and a pH of 7.0, that is increased at least 5 fold over the unsolvated form, compositions with a dissolution rate in SGF that is increased at least 5 fold over the unsolvated form, compositions with a dissolution rate in SIF that is increased at least 5 fold over the unsolvated form.
The present invention demonstrates that the length of time in which celecoxib or other APIs remains in solution can be increased to a surprising high degree by using a PG solvate form as discussed herein. The presence of propylene glycol allows the formation of a supersaturated solution of the API and a high concentration of API will remain in solution for an extended period of time. Celecoxib, for example, has a solubility in water of less than 1 microgram/mL and cannot be maintained as a supersaturated solution for any appreciable time. The present invention has drawn compositions that can be maintained for a period of time (e.g., 15, 30, 45, 60, minutes and longer) as supersaturated solutions at concentrations 2, 3, 5, 7, 10, 20, 30, 40, 50, 60, 70, 80, 90, or 100%, or by 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 40, 50, 75, 100, 125, 150, 175, 200, 250, 300, 350, 400, 500, 1000, 10,000, or 100,000 fold greater than the solubility of the unsolvated form in the same solution (e.g., water or SGF).
The methods of the present invention can be used to make a pharmaceutical API formulation with greater solubility, dissolution, bioavailability, AUC, reduced time to Tmax, the average time from administration to reach peak blood serum levels, higher Cmax, the average maximum blood serum concentration of API following administration, and longer T1/2, the average terminal half-life of API blood serum concentration following Tmax, when compared to the unsolvated form.
AUC is the area under the plot of plasma concentration of API (not logarithm of the concentration) against time after API administration. The area is conveniently determined by the “trapezoidal rule”: the data points are connected by straight line segments, perpendiculars are erected from the abscissa to each data point, and the sum of the areas of the triangles and trapezoids so constructed is computed. When the last measured concentration (Cn, at time tn) is not zero, the AUC from tn to infinite time is estimated by Cn/kel.
The AUC is of particular use in estimating bioavailability of drugs, and in estimating total clearance of drugs (ClT). Following single intravenous doses, AUC=D/ClT, where D is the dose, for single compartment systems obeying first-order elimination kinetics; alternatively, AUC=C0/kel, where kel is the drug elimination rate constant. With routes other than the intravenous AUC=F·D/ClT, where F is the bioavailability of the drug.
Thus, in a further aspect, the present invention provides a process for modulating the bioavailability of an API when administered in its normal and effective dose range, whereby the AUC is increased, the time to Tmax is reduced, or Cmax is increased, which process comprises the preparation of a PG solvate.
Examples of the above embodiments include: compositions with a time to Tmax that is reduced by at least 10% as compared to the neutral free form, compositions with a time to Tmax that is reduced by at least 20% over the free form, compositions with a time to Tmax that is reduced by at least 40% over the free form, compositions with a time to Tmax that is reduced by at least 50% over the free form, compositions with a Tmax that is reduced by at least 60% over the free form, compositions with a Tmax that is reduced by at least 70% over the free form, compositions with a Tmax that is reduced by at least 80% over the free form, compositions with a Cmax that is increased by at least 20% over the free form, compositions with a Cmax that is increased by at least 30% over the free form, compositions with a Cmax that is increased by at least 40% over the free form, compositions with a Cmax that is increased by at least 50% over the free form, compositions with a Cmax that is increased by at least 60% over the free form, compositions with a Cmax that is increased by at least 70% over the free form, compositions with a Cmax that is increased by at least 80% over the free form, compositions with a Cmax that is increased by at least 2 times the free form, compositions with a Cmax that is increased by at least 3 times the free form, compositions with a Cmax that is increased by at least 4 times the free form, compositions with a Cmax that is increased by at least 5 times the free form, compositions with a Cmax that is increased by at least 6 times the free form, compositions with a Cmax that is increased by at least 7 times the free form, compositions with a Cmax that is increased by at least 8 times the free form, compositions with a Cmax that is increased by at least 9 times the free form, compositions with a Cmax that is increased by at least 10 times the free form, compositions with an AUC that is increased by at least 10% over the free form, compositions with an AUC that is increased by at least 20% over the free form, compositions with an AUC that is increased by at least 30% over the free form, compositions with an AUC that is increased by at least 40% over the free form, compositions with an AUC that is increased by at least 50% over the free form, compositions with an AUC that is increased by at least 60% over the free form, compositions with an AUC that is increased by at least 70% over the free form, compositions with an AUC that is increased by at least 80% over the free form, compositions with an AUC that is increased by at least 1 times the free form, compositions with an AUC that is increased by at least 2 times the free form, compositions with an AUC that is increased by at least 3 times the free form, or compositions with an AUC that is increased by at least 4 times the free form.
The uptake of a drug by a subject can also be assessed in terms of maximum blood serum concentration and time to reach maximum blood serum concentration. Pharmaceutical compositions with a more rapid onset to therapeutic effect typically reach a higher maximum blood serum concentration (Cmax) a shorter time after oral administration (Tmax). Preferably, compositions of the present invention have a higher Cmax and/or a shorter Tmax than in the unsolvated form. The Tmax for the compositions of the present invention occurs within about 60 minutes, 55 minutes, 50 minutes, 45 minutes, 40 minutes, 35 minutes, 30 minutes, 25 minutes, 20 minutes, 15 minutes, 10 minutes, or within about 5 minutes of administration (e.g., oral administration). Even more preferably, the therapeutic effects of compositions of the present invention begin to occur within about 60 minutes, 55 minutes, 50 minutes, 45 minutes, 40 minutes, 35 minutes, 30 minutes, within about 25 minutes, within about 20 minutes, within about 15 minutes, within about 10 minutes, or within about 5 minutes of administration (e.g., oral administration).
Compositions of the present invention have a bioavailability greater than their respective unsolvated forms. In other embodiments, the compositions of the present invention have a bioavailability of at least 50%, 60%, 65%, 70%, 75%, 80%, 85%, 87%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%.
In a particular embodiment of the present invention, administration of celecoxib PG solvate to a subject may result in effective pain relief. Pain relief can be attained by inter alia reaching an appropriate blood serum concentration of a suitable analgesic. In the case of the selective COX-2 inhibitor celecoxib, about 250 ng/mL is an appropriate concentration for the relief of pain of various causes. Any standard pharmacokinetic protocol can be used to determine blood serum concentration profile in humans following oral administration of a celecoxib formulation, and thereby establish whether that formulation meets the pharmacokinetic criteria set out herein. The prior art includes many examples of pharmacokinetic studies and as such U.S. Pat. No. 6,579,895 and WO 01/91750 are hereby included as references in their entirety.
In a further aspect the present invention provides a process for improving the dose response of an API by making a composition of the present invention. Dose response is the quantitative relationship between the magnitude of response and the dose inducing the response and may be measured by conventional means known in the art. The curve relating therapeutic effect (as the dependent variable) to dose (as the independent variable) for an API-cell system is the “dose-response curve”. Typically, the dose-response curve is the measured response to an API plotted against the dose of the API (mg/kg) given. The dose response curve can also be a curve of AUC against the dose of the API given.
The dose-response curve for many APIs (e.g. presently-marketed celecoxib (CELEBREXTM)) is nonlinear. Preferably, the dose-response curves for the PG solvate compositions of the present invention are linear or contain a larger linear region than presently-marketed celecoxib. A preferred embodiment of the present invention may incorporate a dose-response curve with a linear slope that is steeper than that of celecoxib. This would allow a faster-onset of therapeutic relief from a smaller dosage of API. An initially steep dose-response curve which gradually levels out could be employed to generate a controlled-release formulation. Also, the absorption or uptake of many APIs (e.g. presently-marketed celecoxib) depends in part on food effects, such that uptake of the API increases when taken with food, especially fatty food. Preferably, uptake of the PG solvates of the present invention exhibit a decreased dependence on food, such that the difference in uptake of the PG solvates when taken with food and when not taken with food is less than the difference in uptake of the unsolvated form.
The compositions of the present invention, including the active pharmaceutical ingredient (API) and formulations comprising the API, are suitably stable for pharmaceutical use. Preferably, the API or formulations thereof of the present invention are stable such that when stored at 30 degrees C. for 2 years, less than 0.2% of any one degradant is formed. The term degradant refers herein to product(s) of a single type of chemical reaction. For example, if a hydrolysis event occurs that cleaves a molecule into two products, for the purpose of the present invention, it would be considered a single degradant. More preferably, when stored at 40 degrees C. for 2 years, less than 0.2% of any one degradant is formed. Alternatively, when stored at 30 degrees C. for 3 months, less than 0.2% or 0.15%, or 0.1% of any one degradant is formed, or when stored at 40 degrees C. for 3 months, less than 0.2% or 0.15%, or 0.1% of any one degradant is formed. Further alternatively, when stored at 60 degrees C. for 4 weeks, less than 0.2% or 0.15%, or 0.1% of any one degradant is formed. The relative humidity (RH) may be specified as ambient (RH), 75% (RH), or as any single integer between 1 to 99%.
APIs prepared in the form of propylene glycol solvates have several important advantages over other solvates and their free form counterparts. In general, solvates are more commonly formed with water, methanol, ethanol, or other alcohols than with propylene glycol. These more common solvates are more easily removed from the crystal matrix by elevated temperatures than propylene glycol. PG solvates have an increased thermal stability over those of more traditional solvates. Also, PG solvates are generally more pharmaceutically acceptable than other common solvates, including those formed from alcohols other than ethanol. Investigations of the PG solvates of the present invention have shown fewer solvation states than hydration states. Reference compounds for PG solvates can be unsolvated free acid, unsolvated free base, zwitter ions, hydrates, or other solvates (e.g. methanol, ethanol, etc.). This decrease in form diversity associated with PG solvates can lead to more predictability and more consistent results during production and quality control. Stabilization of a desired solvate or polymorph can be achieved by causing the less desirable forms (e.g. solvates, polymorphs, hydrates) to be energetically less favorable than the desired form. In this way, PG solvates can aid in the production of pharmaceutical formulations with increased form stability.
The present invention further relates to methods of making a pharmaceutical solvate more stable at elevated temperatures (e.g. 30, 40, 50 degrees C.) by producing a PG solvate of the drug. The present invention further relates to methods of making a more pharmaceutically acceptable solvate of many APIs by employing propylene glycol rather than more biologically harmful solvents (e.g. methanol). The present invention further relates to methods of reducing the number of forms (e.g. hydration states, solvation states, polymorphs, etc.) possible for a pharmaceutical solvate.
Pharmaceutically acceptable PG solvates can be administered by controlled- or delayed-release means. Controlled-release pharmaceutical products have a common goal of improving drug therapy over that achieved by their non-controlled release counterparts. Ideally, the use of an optimally designed controlled-release preparation in medical treatment is characterized by a minimum of drug substance being employed to cure or control the condition in a minimum amount of time. Advantages of controlled-release formulations include: 1) extended activity of the drug; 2) reduced dosage frequency; 3) increased patient compliance; 4) usage of less total drug; 5) reduction in local or systemic side effects; 6) minimization of drug accumulation; 7) reduction in blood level fluctuations; 8) improvement in efficacy of treatment; 9) reduction of potentiation or loss of drug activity; and 10) improvement in speed of control of diseases or conditions. (Kim, Cherng-ju, Controlled Release Dosage Form Design, Technomic Publishing, Lancaster, Pa.: 2000).
Conventional dosage forms generally provide rapid or immediate drug release from the formulation. Depending on the pharmacology and pharmacokinetics of the drug, use of conventional dosage forms can lead to wide fluctuations in the concentrations of the drug in a patient's blood and other tissues. These fluctuations can impact a number of parameters, such as dose frequency, onset of action, duration of efficacy, maintenance of therapeutic blood levels, toxicity, side effects, and the like. Advantageously, controlled-release formulations can be used to control a drug's onset of action, duration of action, plasma levels within the therapeutic window, and peak blood levels. In particular, controlled- or extended-release dosage forms or formulations can be used to ensure that the maximum effectiveness of a drug is achieved while minimizing potential adverse effects and safety concerns, which can occur both from under dosing a drug (i.e., going below the minimum therapeutic levels) as well as exceeding the toxicity level for the drug.
Most controlled-release formulations are designed to initially release an amount of drug (active ingredient) that promptly produces the desired therapeutic effect, and gradually and continually release other amounts of drug to maintain this level of therapeutic or prophylactic effect over an extended period of time. In order to maintain this constant level of drug in the body, the drug must be released from the dosage form at a rate that will replace the amount of drug being metabolized and excreted from the body. Controlled-release of an active ingredient can be stimulated by various conditions including, but not limited to, pH, ionic strength, osmotic pressure, temperature, enzymes, water, and other physiological conditions or compounds.
A variety of known controlled- or extended-release dosage forms, formulations, and devices can be adapted for use with the PG solvates of the present invention. Examples include, but are not limited to, those described in U.S. Pat. Nos. 3,845,770; 3,916,899; 3,536,809; 3,598,123; 4,008,719; 5,674,533; 5,059,595; 5,591,767; 5,120,548; 5,073,543; 5,639,476; 5,354,556; 5,733,566; and 6,365,185 B1; each of which is incorporated herein by reference. These dosage forms can be used to provide slow or controlled-release of one or more active ingredients using, for example, hydroxypropylmethyl cellulose, other polymer matrices, gels, permeable membranes, osmotic systems (such as OROS® (Alza Corporation, Mountain View, Calif. USA)), multilayer coatings, microparticles, liposomes, or microspheres or a combination thereof to provide the desired release profile in varying proportions. Additionally, ion exchange materials can be used to prepare immobilized, adsorbed salt forms and thus effect controlled delivery of the drug. Examples of specific anion exchangers include, but are not limited to, Duolite® A568 and Duolite® AP143 (Rohm & Haas, Spring House, Pa. USA).
One embodiment of the invention encompasses a unit dosage form which comprises a pharmaceutically acceptable PG solvate, or a polymorph, solvate, hydrate, dehydrate, co-crystal, anhydrous, or amorphous form thereof, and one or more pharmaceutically acceptable excipients or diluents, wherein the pharmaceutical composition or dosage form is formulated for controlled-release. Specific dosage forms utilize an osmotic drug delivery system.
A particular and well-known osmotic drug delivery system is referred to as OROS® (Alza Corporation, Mountain View, Calif. USA). This technology can readily be adapted for the delivery of compounds and compositions of the invention. Various aspects of the technology are disclosed in U.S. Pat. Nos. 6,375,978 B1; 6,368,626 B1; 6,342,249 B1; 6,333,050 B2; 6,287,295 B1; 6,283,953 B1; 6,270,787 B1; 6,245,357 B1; and 6,132,420; each of which is incorporated herein by reference. Specific adaptations of OROS® that can be used to administer compounds and compositions of the invention include, but are not limited to, the OROS® Push-PullTM, Delayed Push-PullTM, Multi-Layer Push-PullTM, and Push-StickTM Systems, all of which are well known. See, e.g., http://www.alza.com.
Additional OROS® systems that can be used for the controlled oral delivery of compounds and compositions of the invention include OROS®-CT and L-OROS®. Id.; see also, Delivery Times, vol. II, issue II (Alza Corporation).
Conventional OROS® oral dosage forms are made by compressing a drug powder (e.g., celecoxib sodium PG solvate) into a hard tablet, coating the tablet with cellulose derivatives to form a semi-permeable membrane, and then drilling an orifice in the coating (e.g., with a laser). (Kim, Cherng-ju, Controlled Release Dosage Form Design, Technomic Publishing, Lancaster, Pa.: 2000). The advantage of such dosage forms is that the delivery rate of the drug is not influenced by physiological or experimental conditions. Even a drug with a pH-dependent solubility can be delivered at a constant rate regardless of the pH of the delivery medium. But because these advantages are provided by a build-up of osmotic pressure within the dosage form after administration, conventional OROS® drug delivery systems cannot be used to effectively deliver drugs with low water solubility. Because PG solvates and complexes of this invention (e.g., celecoxib sodium PG solvate) are far more soluble in water than unsolvated forms, they are well suited for osmotic-based delivery to patients.
A specific dosage form of the invention comprises: a wall defining a cavity, the wall having an exit orifice formed or formable therein and at least a portion of the wall being semipermeable; an expandable layer located within the cavity remote from the exit orifice and in fluid communication with the semipermeable portion of the wall; a dry or substantially dry state drug layer located within the cavity adjacent to the exit orifice and in direct or indirect contacting relationship with the expandable layer; and a flow-promoting layer interposed between the inner surface of the wall and at least the external surface of the drug layer located within the cavity, wherein the drug layer comprises a PG solvate, or a polymorph, solvate, hydrate, dehydrate, co-crystal, anhydrous, or amorphous form thereof. See U.S. Pat. No. 6,368,626, the entirety of which is incorporated herein by reference.
Another specific dosage form of the invention comprises: a wall defining a cavity, the wall having an exit orifice formed or formable therein and at least a portion of the wall being semipermeable; an expandable layer located within the cavity remote from the exit orifice and in fluid communication with the semipermeable portion of the wall; a drug layer located within the cavity adjacent the exit orifice and in direct or indirect contacting relationship with the expandable layer; the drug layer comprising a liquid, active agent formulation absorbed in porous particles, the porous particles being adapted to resist compaction forces sufficient to form a compacted drug layer without significant exudation of the liquid, active agent formulation, the dosage form optionally having a placebo layer between the exit orifice and the drug layer, wherein the active agent formulation comprises a PG solvate, or a polymorph, solvate, hydrate, dehydrate, co-crystal, anhydrous, or amorphous form thereof. See U.S. Pat. No. 6,342,249, the entirety of which is incorporated herein by reference.
Excipients employed in pharmaceutical compositions of the present invention can be solids, semi-solids, liquids or combinations thereof. Compositions of the invention containing excipients can be prepared by any known technique of pharmacy that comprises admixing an excipient with a drug or therapeutic agent. A pharmaceutical composition of the invention contains a desired amount of API per dose unit and, if intended for oral administration, can be in the form, for example, of a tablet, a caplet, a pill, a hard or soft capsule, a lozenge, a cachet, a dispensable powder, granules, a suspension, an elixir, a dispersion, a liquid, or any other form reasonably adapted for such administration. Presently preferred are oral dosage forms that are discrete dose units each containing a predetermined amount of the drug, such as tablets or capsules.
Non-limiting examples follow of excipients that can be used to prepare pharmaceutical compositions of the invention.
Pharmaceutical compositions of the invention optionally comprise one or more pharmaceutically acceptable carriers or diluents as excipients. Suitable carriers or diluents illustratively include, but are not limited to, either individually or in combination, lactose, including anhydrous lactose and lactose monohydrate; starches, including directly compressible starch and hydrolyzed starches (e.g., CelutabTM and EmdexTM); mannitol; sorbitol; xylitol; dextrose (e.g., CereloseTM 2000) and dextrose monohydrate; dibasic calcium phosphate dihydrate; sucrose-based diluents; confectioner's sugar; monobasic calcium sulfate monohydrate; calcium sulfate dihydrate; granular calcium lactate trihydrate; dextrates; inositol; hydrolyzed cereal solids; amylose; celluloses including microcrystalline cellulose, food grade sources of alpha- and amorphous cellulose (e.g., RexcelJ), powdered cellulose, hydroxypropylcellulose (HPC) and hydroxypropylmethylcellulose (HPMC); calcium carbonate; glycine; bentonite; block co-polymers; polyvinylpyrrolidone; and the like. Such carriers or diluents, if present, constitute in total about 5% to about 99%, preferably about 10% to about 85%, and more preferably about 20% to about 80%, of the total weight of the composition. The carrier, carriers, diluent, or diluents selected preferably exhibit suitable flow properties and, where tablets are desired, compressibility.
Lactose, mannitol, dibasic sodium phosphate, and microcrystalline cellulose (particularly Avicel PH microcrystalline cellulose such as Avicel PH 101), either individually or in combination, are preferred diluents. These diluents are chemically compatible with celecoxib. The use of extragranular microcrystalline cellulose (that is, microcrystalline cellulose added to a granulated composition) can be used to improve hardness (for tablets) and/or disintegration time. Lactose, especially lactose monohydrate, is particularly preferred. Lactose typically provides compositions having suitable release rates of celecoxib, stability, pre-compression flowability, and/or drying properties at a relatively low diluent cost. It provides a high density substrate that aids densification during granulation (where wet granulation is employed) and therefore improves blend flow properties and tablet properties.
Pharmaceutical compositions of the invention optionally comprise one or more pharmaceutically acceptable disintegrants as excipients, particularly for tablet formulations. Suitable disintegrants include, but are not limited to, either individually or in combination, starches, including sodium starch glycolate (e.g., ExplotabTM of PenWest) and pregelatinized corn starches (e.g., NationalTM 1551 of National Starch and Chemical Company, NationalTM 1550, and ColorconTM 1500), clays (e.g., VeegumTM HV of R.T. Vanderbilt), celluloses such as purified cellulose, microcrystalline cellulose, methylcellulose, carboxymethylcellulose and sodium carboxymethylcellulose, croscarmellose sodium (e.g., Ac-Di-SolTM of FMC), alginates, crospovidone, and gums such as agar, guar, locust bean, karaya, pectin and tragacanth gums.
Disintegrants may be added at any suitable step during the preparation of the composition, particularly prior to granulation or during a lubrication step prior to compression. Such disintegrants, if present, constitute in total about 0.2% to about 30%, preferably about 0.2% to about 10%, and more preferably about 0.2% to about 5%, of the total weight of the composition.
Croscarmellose sodium is a preferred disintegrant for tablet or capsule disintegration, and, if present, preferably constitutes about 0.2% to about 10%, more preferably about 0.2% to about 7%, and still more preferably about 0.2% to about 5%, of the total weight of the composition. Croscarmellose sodium confers superior intragranular disintegration capabilities to granulated pharmaceutical compositions of the present invention.
Pharmaceutical compositions of the invention optionally comprise one or more pharmaceutically acceptable binding agents or adhesives as excipients, particularly for tablet formulations. Such binding agents and adhesives preferably impart sufficient cohesion to the powder being tableted to allow for normal processing operations such as sizing, lubrication, compression and packaging, but still allow the tablet to disintegrate and the composition to be absorbed upon ingestion. Such binding agents may also prevent or inhibit crystallization or recrystallization of a celecoxib salt of the present invention once the salt has been dissolved in a solution. Suitable binding agents and adhesives include, but are not limited to, either individually or in combination, acacia; tragacanth; sucrose; gelatin; glucose; starches such as, but not limited to, pregelatinized starches (e.g., NationalTM 1511 and NationalTM 1500); celluloses such as, but not limited to, methylcellulose and carmellose sodium (e.g., TyloseTM); alginic acid and salts of alginic acid; magnesium aluminum silicate; PEG; guar gum; polysaccharide acids; bentonites; povidone, for example povidone K-15, K-30 and K-29/32; polymethacrylates; HPMC; hydroxypropylcellulose (e.g., KlucelTM of Aqualon); and ethylcellulose (e.g., EthocelTM of the Dow Chemical Company). Such binding agents and/or adhesives, if present, constitute in total about 0.5% to about 25%, preferably about 0.75% to about 15%, and more preferably about 1% to about 10%, of the total weight of the pharmaceutical composition.
Many of the binding agents are polymers comprising amide, ester, ether, alcohol or ketone groups and, as such, are preferably included in pharmaceutical compositions of the present invention. Polyvinylpyrrolidones such as povidone K-30 are especially preferred. Polymeric binding agents can have varying molecular weight, degrees of crosslinking, and grades of polymer. Polymeric binding agents can also be copolymers, such as block co-polymers that contain mixtures of ethylene oxide and propylene oxide units. Variation in these units' ratios in a given polymer affects properties and performance. Examples of block co-polymers with varying compositions of block units are Poloxamer 188 and Poloxamer 237 (BASF Corporation).
Pharmaceutical compositions of the invention optionally comprise one or more pharmaceutically acceptable wetting agents as excipients. Non-limiting examples of surfactants that can be used as wetting agents in pharmaceutical compositions of the invention include quaternary ammonium compounds, for example benzalkonium chloride, benzethonium chloride and cetylpyridinium chloride, dioctyl sodium sulfosuccinate, polyoxyethylene alkylphenyl ethers, for example nonoxynol 9, nonoxynol 10, and octoxynol 9, poloxamers (polyoxyethylene and polyoxypropylene block copolymers), polyoxyethylene fatty acid glycerides and oils, for example polyoxyethylene (8) caprylic/capric mono- and diglycerides (e.g., LabrasolTM of Gattefosse), polyoxyethylene (35) castor oil and polyoxyethylene (40) hydrogenated castor oil; polyoxyethylene alkyl ethers, for example polyoxyethylene (20) cetostearyl ether, polyoxyethylene fatty acid esters, for example polyoxyethylene (40) stearate, polyoxyethylene sorbitan esters, for example polysorbate 20 and polysorbate 80 (e.g., TweenTM 80 of ICI), propylene glycol fatty acid esters, for example propylene glycol laurate (e.g., LauroglycolTM of Gattefosse), sodium lauryl sulfate, fatty acids and salts thereof, for example oleic acid, sodium oleate and triethanolamine oleate, glyceryl fatty acid esters, for example glyceryl monostearate, sorbitan esters, for example sorbitan monolaurate, sorbitan monooleate, sorbitan monopalmitate and sorbitan monostearate, tyloxapol, and mixtures thereof. Such wetting agents, if present, constitute in total about 0.25% to about 15%, preferably about 0.4% to about 10%, and more preferably about 0.5% to about 5%, of the total weight of the pharmaceutical composition.
Wetting agents that are anionic surfactants are preferred. Sodium lauryl sulfate is a particularly preferred wetting agent. Sodium lauryl sulfate, if present, constitutes about 0.25% to about 7%, more preferably about 0.4% to about 4%, and still more preferably about 0.5% to about 2%, of the total weight of the pharmaceutical composition.
Pharmaceutical compositions of the invention optionally comprise one or more pharmaceutically acceptable lubricants (including anti-adherents and/or glidants) as excipients. Suitable lubricants include, but are not limited to, either individually or in combination, glyceryl behapate (e.g., CompritolTM 888 of Gattefosse); stearic acid and salts thereof, including magnesium, calcium and sodium stearates; hydrogenated vegetable oils (e.g., SterotexTM of Abitec); colloidal silica; talc; waxes; boric acid; sodium benzoate; sodium acetate; sodium fumarate; sodium chloride; DL-leucine; PEG (e.g., CarbowaxTM 4000 and CarbowaxTM 6000 of the Dow Chemical Company); sodium oleate; sodium lauryl sulfate; and magnesium lauryl sulfate. Such lubricants, if present, constitute in total about 0.1% to about 10%, preferably about 0.2% to about 8%, and more preferably about 0.25% to about 5%, of the total weight of the pharmaceutical composition.
Magnesium stearate is a preferred lubricant used, for example, to reduce friction between the equipment and granulated mixture during compression of tablet formulations.
Suitable anti-adherents include, but are not limited to, talc, cornstarch, DL-leucine, sodium lauryl sulfate and metallic stearates. Talc is a preferred anti-adherent or glidant used, for example, to reduce formulation sticking to equipment surfaces and also to reduce static in the blend. Talc, if present, constitutes about 0.1% to about 10%, more preferably about 0.25% to about 5%, and still more preferably about 0.5% to about 2%, of the total weight of the pharmaceutical composition.
Glidants can be used to promote powder flow of a solid formulation. Suitable glidants include, but are not limited to, colloidal silicon dioxide, starch, talc, tribasic calcium phosphate, powdered cellulose and magnesium trisilicate. Colloidal silicon dioxide is particularly preferred.
Other excipients such as colorants, flavors and sweeteners are known in the pharmaceutical art and can be used in pharmaceutical compositions of the present invention. Tablets can be coated, for example with an enteric coating, or uncoated. Compositions of the invention can further comprise, for example, buffering agents.
Optionally, one or more effervescent agents can be used as disintegrants and/or to enhance organoleptic properties of pharmaceutical compositions of the invention. When present in pharmaceutical compositions of the invention to promote dosage form disintegration, one or more effervescent agents are preferably present in a total amount of about 30% to about 75%, and preferably about 45% to about 70%, for example about 60%, by weight of the pharmaceutical composition.
According to a particularly preferred embodiment of the invention, an effervescent agent, present in a solid dosage form in an amount less than that effective to promote disintegration of the dosage form, provides improved dispersion of the celecoxib in an aqueous medium. Without being bound by theory, it is believed that the effervescent agent is effective to accelerate dispersion of the drug, such as celecoxib, from the dosage form in the gastrointestinal tract, thereby further enhancing absorption and rapid onset of therapeutic effect. When present in a pharmaceutical composition of the invention to promote intragastrointestinal dispersion but not to enhance disintegration, an effervescent agent is preferably present in an amount of about 1% to about 20%, more preferably about 2.5% to about 15%, and still more preferably about 5% to about 10%, by weight of the pharmaceutical composition.
An “effervescent agent” herein is an agent comprising one or more compounds which, acting together or individually, evolve a gas on contact with water. The gas evolved is generally oxygen or, most commonly, carbon dioxide. Preferred effervescent agents comprise an acid and a base that react in the presence of water to generate carbon dioxide gas. Preferably, the base comprises an alkali metal or alkaline earth metal carbonate or bicarbonate and the acid comprises an aliphatic carboxylic acid.
Non-limiting examples of suitable bases as components of effervescent agents useful in the invention include carbonate salts (e.g., calcium carbonate), bicarbonate salts (e.g., sodium bicarbonate), sesquicarbonate salts, and mixtures thereof. Calcium carbonate is a preferred base.
Non-limiting examples of suitable acids as components of effervescent agents and/or solid organic acids useful in the invention include citric acid, tartaric acid (as D-, L-, or D/L-tartaric acid), malic acid, maleic acid, fumaric acid, adipic acid, succinic acid, acid anhydrides of such acids, acid salts of such acids, and mixtures thereof. Citric acid is a preferred acid.
In a preferred embodiment of the invention, where the effervescent agent comprises an acid and a base, the weight ratio of the acid to the base is about 1:100 to about 100:1, more preferably about 1:50 to about 50:1, and still more preferably about 1:10 to about 10:1. In a further preferred embodiment of the invention, where the effervescent agent comprises an acid and a base, the ratio of the acid to the base is approximately stoichiometric.
Excipients which solubilize metal salts of drugs like celecoxib typically have both hydrophilic and hydrophobic regions, or are preferably amphiphilic or have amphiphilic regions. One type of amphiphilic or partially-amphiphilic excipient comprises an amphiphilic polymer or is an amphiphilic polymer. A specific amphiphilic polymer is a polyalkylene glycol, which is commonly comprised of ethylene glycol and/or propylene glycol subunits. Such polyalkylene glycols can be esterified at their termini by a carboxylic acid, ester, acid anhyride or other suitable moiety. Examples of such excipients include poloxamers (symmetric block copolymers of ethylene glycol and propylene glycol; e.g., poloxamer 237), polyalkyene glycolated esters of tocopherol (including esters formed from a di- or multi-functional carboxylic acid; e.g., d-alpha-tocopherol polyethylene glycol-1000 succinate), and macrogolglycerides (formed by alcoholysis of an oil and esterification of a polyalkylene glycol to produce a mixture of mono-, di- and tri-glycerides and mono- and di-esters; e.g., stearoyl macrogol-32 glycerides). Such pharmaceutical compositions are advantageously administered orally.
Solid dosage forms of the invention can be prepared by any suitable process, not limited to processes described herein.
An illustrative process comprises (a) a step of blending a celecoxib salt of the invention with one or more excipients to form a blend, and (b) a step of tableting or encapsulating the blend to form tablets or capsules, respectively.
In a preferred process, solid dosage forms are prepared by a process comprising (a) a step of blending a drug salt such as a celecoxib salt of the invention with one or more excipients to form a blend, (b) a step of granulating the blend to form a granulate, and (c) a step of tableting or encapsulating the blend to form tablets or capsules respectively. Step (b) can be accomplished by any dry or wet granulation technique known in the art, but is preferably a dry granulation step. A salt of the present invention is advantageously granulated to form particles of about 1 micrometer to about 100 micrometer, about 5 micrometer to about 50 micrometer, or about 10 micrometer to about 25 micrometer. One or more diluents, one or more disintegrants and one or more binding agents are preferably added, for example in the blending step, a wetting agent can optionally be added, for example in the granulating step, and one or more disintegrants are preferably added after granulating but before tableting or encapsulating. A lubricant is preferably added before tableting. Blending and granulating can be performed independently under low or high shear. A process is preferably selected that forms a granulate that is uniform in drug content, that readily disintegrates, that flows with sufficient ease so that weight variation can be reliably controlled during capsule filling or tableting, and that is dense enough in bulk so that a batch can be processed in the selected equipment and individual doses fit into the specified capsules or tablet dies.
In an alternative embodiment, solid dosage forms are prepared by a process that includes a spray drying step, wherein a celecoxib salt is suspended with one or more excipients in one or more sprayable liquids, preferably a non-protic (e.g., non-aqueous or nonalcoholic) sprayable liquid, and then is rapidly spray dried over a current of warm air.
A granulate or spray dried powder resulting from any of the above illustrative processes can be compressed or molded to prepare tablets or encapsulated to prepare capsules. Conventional tableting and encapsulation techniques known in the art can be employed. Where coated tablets are desired, conventional coating techniques are suitable.
Excipients for tablet compositions of the invention are preferably selected to provide a disintegration time of less than about 30 minutes, preferably about 25 minutes or less, more preferably about 20 minutes or less, and still more preferably about 15 minutes or less, in a standard disintegration assay.
Celecoxib dosage forms of the invention preferably comprise celecoxib in a daily dosage amount of about 10 mg to about 1000 mg, more preferably about 25 mg to about 400 mg, and most preferably about 50 mg to about 200 mg.
In a further embodiment the PG solvate comprises an API from Table 3. For APIs in Table 3 listed as salts, solvates, hydrates, and the like, the PG solvate can either be of the form listed in Table 3 or a PG solvate of the free form, or a PG solvate of another form that is not listed. Table 3 includes the CAS number, chemical name or a PCT or patent reference (each incorporated herein in their entireties). In another embodiment, any one or more of the APIs of Table 3 may be specifically excluded from the present invention. Any APIs currently known in the art may also be specifically excluded from the present invention. For example, azithromycin and cephalosporin may be specifically excluded from the present invention.
Exemplification
Procedure for Raman Acquisition
Acquisition
The sample was either left in the glass vial in which it was processed or an aliquot of the sample was transferred to a glass slide. The glass vial or slide was positioned in the sample chamber. The measurement was made using an AlmegaTM Dispersive Raman (AlmegaTM Dispersive Raman, Thermo-Nicolet, 5225 Verona Road, Madison, Wis. 53711-4495) system fitted with a 785 nm laser source. The sample was manually brought into focus using the microscope portion of the apparatus with a 10× power objective (unless otherwise noted), thus directing the laser onto the surface of the sample. The spectrum was acquired using the parameters outlined in Table 1. (Exposure times and number of exposures may vary; changes to parameters will be indicated for each acquisition.)







TABLE 2







Raman Spectral acquisition parameters










Parameter
Setting Used














Exposure time (s)
2.0



Number of exposures
10



Laser source wavelength
785



(nm)



Laser power (%)
100



Aperture shape
pin hole



Aperture size (um)
100



Spectral range
104-3428



Grating position
Single



Temperature at acquisition
24.0



(degrees C.)










Procedure for Powder X-Ray Diffraction (PXRD)

All powder x-ray diffraction patterns were obtained using the D/Max Rapid X-ray Diffractometer (D/Max Rapid, Contact Rigaku/MSC, 9009 New Trails Drive, The Woodlands, Tex., USA 77381-5209) equipped with a copper source (Cu/Kα 1.5406 Å), manual x-y stage, and 0.3 mm collimator, unless otherwise indicated. The sample was loaded into a 0.3 mm boron rich glass capillary tube (e.g., Charles Supper Company, 15 Tech Circle, Natick Mass. 01760-1024) by sectioning off one end of the tube and tapping the open, sectioned end into a bed of the powdered sample or into the sediment of a slurried precipitate. Note, precipitate can be amorphous or crystalline. The loaded capillary was mounted in a holder that was secured into the x-y stage. A diffractogram was acquired (e.g., Control software: RINT Rapid Control Software, Rigaku Rapid/XRD, version 1.0.0, © 1999 Rigaku Co.) under ambient conditions at a power setting of 46 kV at 40 mA in reflection mode, while oscillating about the omega-axis from 0-5 degrees at 1 degree/s and spinning about the phi-axis at 2 degrees/s. The exposure time was 15 minutes unless otherwise specified. The diffractogram obtained was integrated over 2-theta from 2-60 degrees and chi (1 segment) from 0-360 degrees at a step size of 0.02 degrees using the cyllnt utility in the RINT Rapid display software (Analysis software: RINT Rapid display software, version 1.18, Rigaku/MSC.) provided by Rigaku with the instrument. The dark counts value was set to 8 as per the system calibration (System set-up and calibration by Rigaku); normalization was set to average; the omega offset was set to 180°; and no chi or phi offsets were used for the integration. The analysis software JADE XRD Pattern Processing, versions 5.0 and 6.0 ((81995-2002, Materials Data, Inc. was also used.
The relative intensity of peaks in a diffractogram is not necessarily a limitation of the PXRD pattern because peak intensity can vary from sample to sample, e.g., due to crystalline impurities. Further, the angles of each peak can vary by about +/−0.1 degrees, preferably +/−0.05. The entire pattern or most of the pattern peaks may also shift by about +/−0.1 degree due to differences in calibration, settings, and other variations from instrument to instrument and from operator to operator. The above limitations result in a PXRD error of +/−0.1 degrees 2-theta for each diffraction peak.
Procedure for Differential Scanning Calorimetry (DSC)
An aliquot of the sample was weighed into an aluminum sample pan. (e.g., Pan part # 900786.091; lid part # 900779.901; TA Instruments, 109 Lukens Drive, New Castle, Del. 19720) The sample pan was sealed either by crimping for dry samples or press fitting for wet samples (e.g., hydrated or solvated samples). The sample pan was loaded in to the apparatus (DSC: Q1000 Differential Scanning Calorimeter, TA Instruments, 109 Lukens Drive, New Castle, Del. 19720), which is equipped with an autosampler, and a thermogram was obtained by individually heating the sample (e.g., Control software: Advantage for QW-Series, version 1.0.0.78, Thermal Advantage Release 2.0, © 2001 TA instruments-Water LLC) at a rate of 10 degrees C./min from Tmin (typically 20 degrees C.) to Tmax (typically 300 degrees C.) (Heating rate and temperature range may vary, changes to these parameters will be indicated for each sample) using an empty aluminum pan as a reference. Dry nitrogen (e.g., Compressed nitrogen, grade 4.8, BOC Gases, 575 Mountain Avenue, Murray Hill, N.J. 07974-2082) was used as a sample purge gas and was set at a flow rate of 50 mL/min. Thermal transitions were viewed and analyzed using the analysis software (Analysis Software: Universal Analysis 2000 for Windows 95/95/2000/NT, version 3.1E; Build 3.1.0.40, © 1991-2001TA instruments-Water LLC) provided with the instrument.
Procedure for Thermogravimetric Analysis (TGA)
An aliquot of the sample was transferred into a platinum sample pan. (Pan part # 952019.906; TA Instruments, 109 Lukens Drive, New Castle, Del. 19720) The pan was placed on the loading platform and was then automatically loaded in to the apparatus (TGA: Q500 Thermogravimetric Analyzer, TA Instruments, 109 Lukens Drive, New Castle, Del. 19720) using the control software (Control software: Advantage for QW-Series, version 1.0.0.78, Thermal Advantage Release 2.0, (D 2001 TA instruments-Water LLC). Thermograms were obtained by individually heating the sample at 10 degrees C./min from 25 degrees C. to 300 degrees C. (Heating rate and temperature range may vary, changes in parameters will be indicated for each sample) under flowing dry nitrogen (e.g., Compressed nitrogen, grade 4.8, BOC Gases, 575 Mountain Avenue, Murray Hill, N.J. 07974-2082), with a sample purge flow rate of 60 mL/min and a balance purge flow rate of 40 mL/min. Thermal transitions (e.g. weight changes) were viewed and analyzed using the analysis software (Analysis Software: Universal Analysis 2000 for Windows 95/95/2000/NT, version 3.1E; Build 3.1.0.40, © 1991-2001TA instruments-Water LLC) provided with the instrument.
EXAMPLE 1
Celecoxib Sodium Salt PG Solvate
A propylene glycol solvate of the sodium salt of celecoxib was prepared. To a solution of celecoxib (312 mg; 0.818 mmol) in diethyl ether (6 mL) was added propylene glycol (0.127 mL, 1.73 mmol). To the clear solution was added sodium ethoxide in ethanol (21%, 0.275 mL, 0.817 mmol). After 1 minute, crystals began to form. After 5 minutes, the solid had completely crystallized. The solid was collected by filtration and was washed with additional diethyl ether (10 mL). The off-white solid was then air-dried and collected. The crystalline salt form was identified as a 1:1 solvate of propylene glycol. The solid was characterized by TGA and PXRD. The results are depicted in FIGS. 1 and 2A.
FIG. 1 shows the results of TGA. A weight loss of about 15.6% was observed between about 65 and 200 degrees C. which represents 1 molar equivalent of propylene glycol to celecoxib Na salt. FIG. 2A shows the results of PXRD. Peaks, in 2-theta angles, that can be used to characterize the solvate include any 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 of the following: 3.77, 7.57, 8.21, 11.33, 14.23, 16.13, 18.69, 20.65, 22.69 and 24.77 degrees or any one or any combination of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more peaks of FIG. 2A. The TGA thermogram or PXRD diffractogram data may be used alone or in any combination to characterize the solvate. A 0.8 mm collimator was used during acquisition of the diffractogram.
Several closely related, yet distinguishable, PXRD diffractograms have been obtained by performing the above synthesis several times. FIGS. 2B, 2C, and 2D are additional diffractograms of the propylene glycol solvate of celecoxib sodium salt. A comparison of these diffractograms yields a number of noticeable differences. For example, the peak at 8.21 degrees 2-theta in FIG. 2A is not present in FIG. 2B or 2C. Another peak at 8.79 degrees 2-theta, present in FIGS. 2B and 2D, is not found in FIG. 2A or 2C. Other distinctions can also be found between the four diffractograms. Such distinctions in otherwise similar diffractograms suggest the existence of polymorphism or perhaps a variable hydrate.
In another embodiment of the present invention, a PG solvate of an API can give rise to distinct PXRD diffractograms. This can be caused by polymorphism, a variable hydrate, a different environmental condition, etc. In one embodiment, the propylene glycol solvate of celecoxib sodium salt can yield a PXRD pattern with the absence or presence of a peak at 8.21 degrees 2-theta. In another embodiment, the propylene glycol solvate of celecoxib sodium salt can yield a PXRD pattern with the absence or presence of a peak at 8.79 degrees 2-theta.
EXAMPLE 2
Celecoxib Potassium Salt PG Solvate
A propylene glycol solvate of the potassium salt of celecoxib was prepared. To a solution of celecoxib (253 mg, 0.664 mmol) in diethyl ether (6 mL) was added propylene glycol (0.075 mL, 1.02 mmol). To the clear solution was added potassium t-butoxide in tetrahydrofuran (THF) (1 M, 0.66 mL, 0.66 mmol). Crystals immediately began to form. After 5 minutes, the solid had completely crystallized. The solid was collected by filtration and was washed with additional diethyl ether (10 mL). The white solid was then air-dried and collected. The crystalline salt form was found to be a 1:1 propylene glycol solvate of celecoxib K salt. The solid was characterized by TGA and PXRD. The results are depicted in FIGS. 3 and 4.
FIG. 3 shows the results of TGA. A weight loss of about 14.94% was observed between about 65 and about 250 degrees C. which is consistent with 1 molar equivalent of propylene glycol to celecoxib K. FIG. 4 shows the results of PXRD. Peaks, in 2-theta angles, that can be used to characterize the solvate include any 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 of the following: 3.75, 7.47, 11.33, 14.89, 15.65, 18.31, 20.49, 21.73, 22.51, and 24.97 degrees or any one or any combination of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more peaks of FIG. 4.
EXAMPLE 3
Celecoxib Lithium Salt PG Solvate
A propylene gly solvate of the lithium salt of celecoxib was prepared. To a solution of celecoxib (264 mg, 0.693 mmol) in diethyl ether (8 mL) was added propylene glycol (0.075 mL, 1.02 mmol). To the clear solution was added t-butyl lithium in pentane (1.7 M, 0.40 mL, 0.68 mmol). A brown solid formed immediately but dissolved within one minute which subsequently yielded a white fluffy solid. The white solid crystallized completely after 10 minutes. The solid was collected by filtration and was washed with additional diethyl ether (10 mL). The white solid was then air-dried and collected. The crystalline salt form was found to be a 1:1 propylene glycol solvate of celecoxib Li. The solid was characterized by TGA and PXRD.
The results of TGA are depicted in FIG. 5 and show a weight loss of about 16.3% between 50 degrees C. and 210 degrees C. which is consistent with 1 molar equivalent of propylene glycol to celecoxib Li. The results of PXRD are shown in FIG. 6. Characteristic peaks of 2-theta angles that can be used to characterize the salt include any one, or combination of any 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12 of 3.79, 7.51, 8.19, 9.83, 11.41, 15.93, 18.29, 19.19, 19.87, 20.63, 22.01, or 25.09 degrees or any one or any combination of peaks of FIG. 6.
EXAMPLE 4
Naproxen Sodium Salt PG Solvate
A propylene glycol solvate of a sodium salt of naproxen was prepared. To a solution of naproxen (348 mg, 1.51 mmol) in diethyl ether (10 mL) was added propylene glycol (0.200 ml, 2.72 mmol). To the clear solution was added sodium ethoxide in ethanol (21%, 0.750 mL, 2.01 mmol). The solution became slightly yellow due to the sodium ethoxide. After 1 minute, crystals began to form. After 5 minutes, the solid had completely crystallized. The solid was collected by filtration and was washed with diethyl ether (10 mL). The product was then air-dried and collected. The solvate was 2:1 naproxen Na:propylene glycol. The solid was characterized by TGA and PXRD. The TGA thermogram of naproxen sodium salt PG solvate is shown in FIG. 7, and indicates a 13.5 percent weight loss between about 75 and 150 degrees C. This weight loss is consistent with a 2:1 naproxen Na:propylene glycol solvate. The PXRD diffractogram of naproxen sodium salt PG solvate is shown in FIG. 8, and shows peaks at 2-theta angles, including but not limited to, 6.67, 9.65, 13.41, 15.77, 18.55, 20.83, 22.79, and 27.17 degrees. Any one, any two, any three, any four, any five, any six, any seven, or all eight of the above peaks or any one or any combination of peaks in FIG. 8 can be used to characterize naproxen sodium salt PG solvate.
EXAMPLE 5
Preparation of Olanzapine PG Solvate
Olanzapine PG solvate was prepared by dissolving 1.05 g of olanzapine form I in 8 mL of isopropylacetate and 2.0 mL of propylene glycol with heating. The hot liquid was filtered through a 0.2 micrometer nylon syringe filter. Crystallization occurred after cooling to room temperature. The addition of a small amount of seed crystals from a previous reaction followed by sonication for 10 seconds also facilitated crystallization. Olanzapine PG solvate was isolated by suction filtration, rinsed with isopropylacetate and allowed to air dry. The product was a fine yellow powder. The crystals grew in three dimensions, yielding chunks.
A second preparation of olanzapine form I PG solvate was completed by dissolving 16.2 mg of olanzapine form I in 0.05 ml of propylene glycol and 0.05 ml of isopropylacetate with heating. The sample was cooled to room temperature and a single crystal from a previous preparation was added. The sample was allowed to sit undisturbed for 2 days during which an aggregate clump of several large crystals grew. The crystals were transferred to filter paper, rinsed with a single drop of isopropylacetate, and dried by dabbing with the filter paper. The rinse procedure was repeated a total of four times with fresh filter paper. Characterization of the product has been achieved via TGA, DSC, PXRD, and Raman spectroscopy.
Results from TGA analysis show an 18.05% weight loss representing loss of about 1 equivalent of propylene glycol (FIG. 9). Results from DSC show a peak endothermic transition at 92.63 degrees C. (FIG. 10).
The PXRD pattern has characteristic peaks as shown for two sample preparations in FIGS. 11A and 11B. Peaks can be seen at 2-theta angles including but not limited to 8.33, 8.95, 11.75, 14.47, 15.61, 17.95, 19.21, 19.57, 20.65, 21.41, 22.03, and 23.29 in FIG. 11A. The crystal can be characterized by any one, any two, any three, any four, any 5, any 6, any 7, any 8, any 9, any 10, any 11, or all 12 of the peaks above or one or a combination of peaks in FIG. 11A. In the second representative sample, peaks can be seen at 2-theta angles including, but not limited to, 8.39, 8.89, 13.95, 14.45, 15.55, 17.91, 19.13, 19.55, 20.61, 21.47, 22.07, and 23.31 in FIG. 11B. The crystal can be characterized by any one, any two, any three, any four, any 5, any 6, any 7, any 8, any 9, any 10, any 11, or all 12 of the peaks above or one or a combination of peaks in FIG. 11B.
Single-crystal x-ray studies of olanzapine form I PG solvate were also completed. FIG. 12 shows a packing diagram of the single-crystal structure of olanzapine form I PG solvate. The unit cell data are as follows: space group P2(1)/c, A=10.4264(9), B=13.3916(11), C=14.4424(12), Alpha=90, Beta=95.503(2), Gamma=90, Volume=2007.2(3).
EXAMPLE 6
Preparation of Cortisone Acetate PG Solvate
Cortisone acetate PG solvate was prepared by dissolving 9.7 mg cortisone acetate in 0.6 mL propylene glycol with heating. Needle-like crystals formed upon cooling, followed by the conversion to large, very thin, rectangular plates over a couple hours.
A second preparation of cortisone acetate PG solvate was completed by dissolving 11.9 mg cortisone acetate in 0.7 mL isopropylacetate with heating to reflux. Upon crystal formation, 0.05 mL propylene glycol was added, heated to reflux to dissolve, and crystals again formed. The resultant crystals were collected and analyzed by PXRD, TGA, and DSC.
A third preparation of cortisone acetate PG solvate was completed by dissolving 65.8 mg cortisone acetate in 7.0 mL isopropylacetate and 0.05 mL propylene glycol with heating. The mixture was cooled slightly and seed crystals from a previous reaction (second preparation above) were added. The resultant crystals form rods, or long rectangular plates that are birefringent when viewed by plane polarized microscopy. Crystals were harvested after 30 minutes and analyzed by single crystal x-ray. Prior to PXRD measurement, the sample was ground, transferred to a vial, and left open to the atmosphere for 4 days.
Results from TGA analysis show a 15.9% weight loss at temperatures up to 150 degrees C. (FIG. 13). 14.9% weight loss occured between 70 and 150 degrees C. while up to 1.2% weight loss occurred at lower temperatures. This weight loss is representative of a cortisone acetate PG solvate with 1.0 equivalents of propylene glycol. DSC was completed in a closed, not sealed aluminium pan from room temperature to 300 degrees C. at 10 degrees/minute (FIG. 14). The compound was discovered to have two endothermic transitions, one at 148 degrees C. with an intensity of 146 J/g, and the second at 237 degrees C. with an intensity of 77 J/g.
The PXRD of cortisone acetate PG solvate crystallized from isopropylacetate/propylene glycol solution is shown in two diffractograms in FIG. 15A and FIG. 15B. Peaks can be seen at 2-theta angles including, but not limited to, 5.31, 10.71, 14.54, 15.66, 18.49, 21.33, and 23.49 degrees. The crystal can be characterized by any one, any two, any three, any four, any five, any six, or any seven, or any combination of the peaks listed above or one or a combination of peaks listed in FIG. 15A. In the second representative sample, peaks can be seen at 2-theta angles including, but not limited to, 5.29, 10.73, 14.57, 15.69, 18.51, 21.39, 23.51, and 27.49 in FIG. 15B. The crystal can be characterized by any one, any two, any three, any four, any 5, any 6, any 7, or all 8 of the peaks above or one or a combination of peaks in FIG. 15B. FIG. 16 shows a PXRD diffractogram of material crystallized from isopropylacetate alone. This is provided only to differentiate the PG solvate from the unsolvated form of the API.
Single-crystal x-ray studies of cortisone acetate PG solvate were also completed.
FIG. 17 shows a packing diagram of the single-crystal structure of cortisone acetate PG solvate. The unit cell data are as follows: space group P2(1), A=9.728(2), B=7.6306(15), C=16.454(3), Alpha=90, Beta=92.568(4), Gamma=90, Volume=1220.2(4).
EXAMPLE 7
Celecoxib Sodium PG Solvate Trihydrate
Preparation:
Celecoxib Na propylene glycol trihydrate was formed by allowing the celecoxib sodium salt propylene glycol solvate to sit at 60% RH and 20 degrees C. for 3 days. (Note: Formation of the trihydrate at 75% and 40 degrees C. occurs as well). The trihydrate begins to form somewhere between 31 and 40% RH at room temperature.
The solid was characterized by TGA and PXRD, which are shown in FIGS. 18 and 19, respectively. FIG. 18 shows the results of the TGA where 9.64% weight loss was observed between room temperature and 60 degrees C. and 13.6% weight loss was observed between 60 degrees C. and 175 degrees C. The PXRD pattern has characteristic peaks at 2-theta angles shown in FIG. 19. Any 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more peaks can be used to characterize the trihydrate, including for example, peaks at 3.47, 6.97, 10.37, 13.97, 16.41, 19.45, 21.29, 22.69, 23.87, and 25.75 degrees. A 0.8 mm collimator was used during acquisition of the diffractogram.
The trihydrate can also be formed by crystallization of celecoxib Na propylene glycol solvate in the presence of H2O. To a solution of celecoxib (136.2 mg; 0.357 mmol) in diethyl ether (6.0 mL), water (0.025 mL; 1.39 mmol), and propylene glycol (0.030 mL; 0.408 mmol) was added sodium ethoxide in ethanol (21 wt. %; 0.135 mL; 0.362 mmol). A solid formed within one minute and was isolated via filtration. The solid was then washed with additional diethyl ether (2.0 mL) and allowed to air dry. This procedure gives essentially the same PXRD pattern but there is a slight excess of water, which is probably surface water.
The solid was characterized by TGA and PXRD, which are shown in FIGS. 20 and 21, respectively. FIG. 20 shows the results of TGA where 10.92% weight loss was observed between room temperature and 50 degrees C. and 12.95% weight loss was observed between 50 degrees C. and 195 degrees C. The PXRD pattern has characteristic peaks at 2-theta angles shown in FIG. 21. Any 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, or more peaks can be used to characterize the trihydrate, including for example, peaks at 3.43, 6.95, 10.25, 13.95, 16.39, 17.39, 17.75, 18.21, 19.43, 21.21, 22.61, and 25.71 degrees. A 0.8 mm collimator was used during acquisition of the diffractogram.
FIGS. 22-24 have been included as reference PXRD diffractograms. FIG. 22 shows the PXRD diffractogram of celecoxib sodium salt. FIG. 23 shows the PXRD diffractogram of celecoxib lithium salt. FIG. 24 shows the PXRD diffractogram of celecoxib potassium salt. Dynamic moisture sorption studies of several embodiments of the present invention have been discussed in PCT/US03/41273 filed on Dec. 24, 2003, entitled “Pharmaceutical Compositions With Improved Dissolution” by Tawa et al, which is hereby incorporated by reference, in its entirety. Dynamic moisture sorption studies can be used to illustrate important characteristics of the solvates of the present invention, such as decreased hygroscopicity or increased form stability.
While this invention has been particularly shown and described with references to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention encompassed by the appended claims.












TABLE 3








Patent
Example of



API Generic Name
API Chemical Name
CAS No.
Reference
Therapeutic Use
Example of Indication





















(−)-amlodipine
3,5-Pyridinedicarboxylic acid, 2-((2-
103129-82-4
WO
9310779
Antihypertensive, other
Hypertension, 



aminoethoxy)methyl)-4-(2-




general



chlorophenyl)-1,4-dihydro-6-methyl-,








3-ethyl-S-methyl ester, (S)-[CAS]







(−)-halofenate
(−)-Benzeneacetic acid, 4-chloro-Alpha-

U.S.
6,262,118
Antidiabetic
Diabetes, Type II



[3-(trifluoromethyl)-phenoxy]-, 2-








(acetylamino)ethyl ester







(R)-salbutamol
1,3-Benzenedimethanol, Alpha1-(((1,1-



Formulation, modified-
Asthma



dimithylethyl)amino)methyl)-4-hydroxy-



release, <=24 hr




[CAS]







(R)-salbutamol
1,3-Benzenedimethanol, Alpha1-(((1,1-
34391-04-3
U.S.
5,547,994
Antiasthma
Asthma



dimethylethyl)amino)methyl)-4-hydroxy-








[CAS]







(R,R)-formoterol
Formamide, N-(2-hydroxy-5-(1-hydroxy-
67346-49-0
U.S.
5,795,564
Antiasthma
Asthma



2-((2-(4-methoxyphenyl)-1-








methylethyl)amino)ethyl)phenyl)- (R-








(R*,R*))-[CAS]







(S)-doxazosin
(S)-1-(4-amino-6,7-dimethoxy-2-
70918-18-2
WO
9409785
Prostate disorders
Benign prostatic 



quinazolinyl)-4-(1,4-benzodioxan-2-yl




hyperplasia



carbonyl)piperazine







(S)-fluoxetine
Benzenepropanamide, N-methyl-



Antimigraine
Migraine



Gamma-(4-(trifluoromethyl)phenoxy)-








(S)







(S)-oxybutynin
Benzeneacetic acid, Alpha-cyclohexyl-
119618-22-3


Urological
Incontinence



Alpha-hydroxy-, 4-(diethylamino)-2-








butynyl ester, (S)-[CAS]







1,2-Naphtho-

524-42-5






quinone








17a-

68-96-2






Hydroxypro-








gesterone








17-Methyl-

58-18-4






testosterone








195mPt-cisplatin
Platinum-195m, diamminedichloro, (SP-

U.S.
6,074,626
Anticancer, alkylating
Cancer, liver



4-2)-







1a-Hydroxy-

41294-56-8






cholecalciferol








1-Naphthyl 

550-97-0






Salicylate








1-Naphthyl-

84-86-6






amine-4-








sulfonic Acid








1-Theobromine- 

5614-56-2






acetic Acid








2,4,6-Tribromo-m-

4619-74-3






cresol








2,6-Diamino-2¢-

617-19-6






butyloxy-3,5¢-








azopyridine








21-Acetoxy-

566-78-9






pregnenolone








2-Amino-4-

695-34-1






picoline








2-Aminothiazole

96-50-4






2-ethoxybenzoic 
2-Ethoxybenzoic acid

DE
5134001
Analgesic, NSAID
Pain, general


acid








2-Naphthol

135-19-3






2-Naphthyl 

93-44-7






Benzoate








2-Naphthyl 

93-43-6






Lactate








2-Naphthyl 

613-78-5






Salicylate








2-p-

80-02-4






Sulfanilyl-








anilinoethanol








2-Thiouracil

141-90-2






3¢,3¢¢,5¢,5¢¢-

76-62-0






Tetrabromophenol-








phthalein








3-Amino-4-

589-44-6






hydroxybutyric 








Acid








3-Bromo-d-

76-29-9






camphor








3-Hydroxy-

10373-81-6






camphor








3-O-

1562-13-6






Lauroylpyridoxol








Diacetate








3-

492-89-7






Pentadecyl-








catechol








3-Quinuclidinol

1619-34-7






4,4¢-Oxydi-2-

821-33-0






butanol








4,4¢-

119-59-5






Sulfinyldianiline








4-Amino-3-

352-21-6






hydroxybutyric 








Acid








4-Amino-3-

1078-21-3






phenylbutyric 








Acid








4-aminosali-
Benzoic acid, 4-amino-2-hydroxy-
65-49-6


GI inflammatory/bowel 
inflammatory 


cylic acid
[CAS]



disorders
bowel disease


4-Chloro-m-

59-50-7






cresol








4-

136-77-6






Hexytresorcinol








4-

3202-84-4






Salicyloyl-








morpholine








5¢-Nitro-2¢-

553-20-8






propoxy-








acetanilide








5-aminolevulinic 
Pentanoic acid, 5-amino-4-oxo-[CAS]
106-60-5


Dermatological
Keratosis


acid,








5-azacitidine
1,3,5-Triazin-2(1H)-one, 4-amino-1-β-
320-67-2


Anticancer, 
Mylodysplastic 



D-ribofuranosyl-[CAS]



antimetabolite
syndrome


5-

5798-94-7






Bromosalicyl-








hydroxamic 








Acid








5F-DF-203
2-(4-Amino-3-methylphenyl)-6-



Anticancer, other
Cancer, breast



hydroxybenzothiazole







5-FU
2,4(1H,3H)-Pyrimidinedione, 5-fluoro
51-21-8


Formulation, parenteral, 
Cancer, general



[CAS]



targeted



5-HT3 


U.S.
6,037,360
Male sexual dysfunction
Premature ejaculation


antagonists








6-Azauridine

54-25-1






6-Mercapto-

50-44-2






purine








8-Hydroxy-

148-24-3






quinoline








9-Amino-

91421-43-1






camptothecin








A-151892
N-[2-(2,2,2-Trifluoro-1-hydroxy-1-



Urological
Overactive bladder



trifluoromethyl-ethyl)-naphthalen-1-yl]








amide







a1-Antitrypsin

9041-92-3






A-5021
6H-Purin-6-one, 2-amino-9-(((1S,2R)-
145512-85-2


Antiviral, other
Infection, varicella 



1,2-




zoster virus



bis(hydroxymethyl)cyclopropyl)methyl)-








1,9-dihydro-[CAS]







abacavir
2-Cyclopentene-1-methanol, 4-(2-
136470-78-5
EP
434450
Antiviral, anti-HIV
Infection, HIV/AIDS



amino-6-(cyclopropylamino)-9H-purin-9-
188062-50-2







yl)-, (1S-cis)-[CAS]







abaperidone
7-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-
183849-43-6
WO
9632389
Neuroleptic
Schizophrenia



yl)piperidin-1-yl]propoxy]-3-








(hydroxymethyl)chromen-4-one







abarelix
D-Alaninamide, N-acetyl-3-(2-
183552-38-7
U.S.
5,843,902
Anticancer, hormonal
Cancer, prostate



naphthalenyl)-D-alanyl-4-chloro-D-








phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-








seryl-N-methyl-L-tyrosyl-D-asparaginyl-








L-leucyl-N6-(1-methylethyl)-L-lysyl-L-








prolyl-[CAS]







Abciximab

143653-53-6






Abecarnil

111841-85-1






abetimus

169147-32-4
U.S.
5,552,391
Immunosuppressant
Lupus erythematosus,








systemic


abiraterone
Androsta-5,16-dien-3-ol, 17-(3-
154229-18-2
GB
2265624
Anticancer, hormonal
Cancer, prostate



pyridinyl)-, acetate (ester), (3β)-[CAS]







a-Bisabolol

515-69-5






ABLC
Amphotericin B [CAS]
1397-89-3


Formulation, conjugate,
Infection, Candida, 




30652-87-0


carbohydrate
general


ABT-751
Benzenesulfonamide, N-[2-[(4-
141430-65-1
EP
472053
Anticancer, other
Cancer, general



hydroxyphenyl)amino]-3-pyridinyl]-4-








methoxy-[CAS]







AC-5216
N-benzyl-N-ethyl-2-(7,8-dihydro-7-
2627-69-2


Anxiolytic
Anxiety, general



methyl-8-oxo-2-phenyl-9H-purin-9-








yl)acetamide







Acadesine

2627-69-2






acamprosate
1-Propanesulfonic acid, 3-
77337-76-9
GB
2051789
Dependence treatment
Addiction, alcohol



(acetylamino)-[CAS]







Acamprosate

77337-73-6






Acarbose

56180-94-0






acebrophylline
7H-Purine-7-acetic acid, 1,2,3,6-
96989-76-3
DE
3425007
Antiasthma
Asthma



tetrahydro-1,3-dimethyl-2,6-dioxo-,








compd. with trans-4-[[(2-amino-3,5-








dibromophenyl)methyl]amino]cyclo-








hexanol (1:1) [CAS]







acebutolol
Butanamide, N-[3-acetyl-4-[2-hydroxy-3-
34381-68-5
U.S.
3,726,919
Antihypertensive, 




[(1-methylethyl)amino]propoxy]phenyl]-,
37517-30-9


adrenergic




(+/−)-[CAS]







Acecainide

32795-44-1






Acecarbromal

77-66-7






aceclofenac
Benzeneacetic acid, 2[(2,6-
89796-99-6
EP
119932
Anti-inflammatory
Pain, musculoskeletal



dichlorophenyl)amino]-, carboxymethyl








ester [CAS]







Acedapsone

77-46-3






Acediasulfone

80-03-5






Acefylline

652-37-9






Aceglutamide

2490-97-3






aceglutamide
Aluminum, pentakis(N2-acetyl-L-
12607-92-0
DE
2127176
Antiulcer
Ulcer, GI, general



glutaminato)tetrahydroxytri-[CAS]







acemetacin
1H-Indole-3-acetic acid, 1-(4-
53164-05-9
U.S.
3,910,952
Anti-inflammatory




chlorobenzoyl)-5-methoxy-2-methyl-,








carboxymethyl ester [CAS]







Acenocoumarol

152-72-7






Acetal

105-57-7






Acetamido-

305-13-5






eugenol








Acetaminophen

103-90-2






Acetaminosalol

118-57-0






Acetanilide

103-84-4






Acetarsone

97-44-9






Acetazolamide

59-66-5






Acetiamine

299-89-8






Acetohexamide

968-81-0






Acetohydroxamic 

546-88-3






Acid








Acetophenazine

2751-68-0






Acetophenone

98-86-2






Acetosulfone

128-12-1






acetoxolone
Olean-12-en-30-oic acid, 3β-hydroxy-
29728-34-5
U.S.
3,764,618
Antiulcer




11-oxo-acetate, aluminium salt [CAS]
6277-14-1






Acetrizoate

129-63-5






Acetyl 

3590-05-4






Sulfamethoxy-








pyrazine








Acetylcarnitine

14992-62-2






Acetylcholine

66-23-9






Acetylcholine

60-31-1






Acetylcysteine

616-91-1






Acetylleucine

149-90-6






Mono-








ethanolamine








Acetyl-

13402-08-9






pheneturide








acetylsalicylic 
Benzoic acid, 2-(acetyloxy)-[CAS]
50-78-2


Formulation, optimized,
Pain, general


acid

530-75-6


microencapsulate



a-Chloralose

15879-93-3






aciclovir
6H-Purin-6-one, 2-amino-1,9-dihydro-9-
59277-89-3


Formulation, dermal, 
Infection, herpes 



[(2-hydroxyethoxy)methyl]-[CAS]



topical
simplex virus


Acifran

72420-38-3






acipimox
Pyrazinecarboxylic acid, 5-methyl-, 4-
51037-30-0
GB
1361967
Hypolipaemic/
Hyperlipidaemia, 



oxide [CAS]



Antiatherosclerosis
general


acitazanolast
Acetic acid, oxo[[3-(1H-tetrazol-5-
114607-46-4
EP
256507
Ophthalmological
Conjunctivitis



yl)phenyl]amino]-[CAS]







acitretin
2,4,6,8-Nonatetraenoic acid, 9-(4-
55079-83-9
GB
1468401
Antipsoriasis
Psoriasis



methoxy-2,3,6-trimethylphenyl)-3,7-








dimethyl-, (all-E)-[CAS]







aclarubicin

57576-44-0
U.S.
3,988,315
Anticancer, antibiotic





75443-99-1






Aclatonium 

55077-30-0






Napadisilate








Aconitine

302-27-2






Acranil ®

1684-42-0






Acriflavine

8048-52-0






Acrisorcin

7527-91-5






acrivastine
2-Propenoic acid, 3-[6-[1-(4-
87848-99-5
EP
85959
Antipruritic/inflamm, 
Rhinitis, allergic, 



methylphenyl)-3-(1-pyrrolidinyl)-1-



allergic
general



propenyl]-2-pyridinyl]-, (E,E)-[CAS]







acrivastine +
Benzenemethanol, Alpha-[1-



Antiallergic, non-asthma
Rhinitis, allergic, 


pseudo-
(methylamino)ethyl]-, hydrochloride, [S-




seasonal


ephedrine
(R*,R)]-, mixtwith 2-Propenoic acid, 3-








[6-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-








1-propenyl]-2-pyridinyl]-, (E,E)-







actagardine 
3,3-dimethyl-1-propylamide HCl



Peptide antibiotic
Infection, general


derivative
monocarboxamide actagardine







Actarit

18699-02-0






ACTH

9002-60-2






Acyclovir

59277-89-3






adapalene
2-Naphthalenecarboxylic acid, 6-(4-
106685-40-9
EP
199636
Antiacne
Acne



methoxy-3-tricyclo[3.3.1.13,7]dec-1-








ylphenyl)-[CAS]







ADCON-L
GL 402 [CAS]
137802-74-5


Formulation, other
Fibrosis, epidural


Adefovir

106941-25-7






adefovir 
Propanoic acid, 2,2-dimethyl-, (((2-(-6-
142340-99-6
EP
205826
Antiviral, other
Infection, hepatitis-B 


dipivoxil
amino-9H-purin-9-




virus



yl)ethoxy)methyl)phosphinyl








idene)bis(oxymethylene)ester-[CAS]







Adenoscan
6-Amino-9-β-D-nbofuranosyl-9H-purine
58-61-7


Imaging agent
Diagnosis, coronary



[CAS]







Adenosine 

56-65-5






Triphosphate








ADEPT

156079-88-8


Immunoconjugate, other
Cancer, colorectal


Adinazolam

37115-32-5






Adiphenine

64-95-9






ADL-10-0101


WO
9732857
Analgesic, other
Pain, general


Adrafinil

63547-13-7






Adrenalone

99-45-6






Adrenochrome

54-06-8






adrogolide
Benzo(f)thieno(2,3-c)quinoline-9,10-
166591-11-3
U.S.
5,597,832
Dependence treatment
Addiction, cocaine



diol, 4,5,5a,6,7,11b-hexahydro-2-propyl-,
171752-56-0







diacetate (ester), hydrochloride (5aR-








trans)-[CAS]







AEOL-10150


U.S.
6,103,714
Neuroprotective
Unspecified


AET

56-10-0






a-Ethylbenzyl 

93-54-9






Alcohol








AF-2259
Benzeneacetic acid, Alpha-methyl-4-(2-
66332-77-2
DE
2726435
Anti-inflammatory
Inflammation, general



methylpropyl)-, 2-methoxyphenyl ester








[CAS]







Afloqualone

56287-74-2






AG-041R
1H-Indole-3-acetamide, 1-(2,2-
199800-49-2
WO
9419322
Alimentary/Metabolic, 
Unspecified



diethoxyethyl)-2,3-dihydro-N-(4-



other




methylphenyl)-3-((((4-








methylphenyl)amino)carbonyl)amino)-2-








oxo-, (3R)-[CAS]







AG-2037
N-(5-[2-(2-amino-4(3H)-oxo-5,6,7,8-



Anticancer, 
Cancer, general



tetrahydropyrido[2,3-d]pyrimidin-6-



antimetabolite




yl)ethy]-4-methylthieno-2-yl)glutamic








acid







a-Glucose-1-

59-56-3






phosphate








AGN-194310
Benzoic acid, 4-((4-(4-ethylphenyl)-2,2-
229961-45-9
WO
9709297
Dermatological
Psoriasis



dimethyl-2H-1-benzothiopyran-6-








yl)ethynyl)-[CAS]







agomelatine
Acetamide, N-(2-(7-methoxy-1-
138112-76-2
EP
447285
Antidepressant
Sleep disorder, 



naphthalenyl)ethyl)-[CAS]




general


Ahistan

518-61-6






AHL-157


U.S.
5,411,972
Hypolipaemic/
Atherosclerosis







Antiatherosclerosis



AIT-034
9H-Purine-9-propanamide, 1,6-dihydro-
138117-48-3
U.S.
5,447,939
Cognition enhancer
Dementia, senile, 



6-oxo-N-(3-(2-oxo-1-pyrrolidinyl)propyl)-




general



[CAS]







AIT-202
N-(2-(5-Hydroxy-1H-indol-3-yl)ethyl]-3-

WO
9957120
Antidepressant
Unspecified



(6-oxo-6,9-dihydro-1H-purin-9-








yl)propionamide







AJ-9677
Acetic acid, ((3-((2R)-2-(((2R)-2-(3-
244081-42-3


Antidiabetic
Diabetes, Type II



chlorophenyl)-2-








hydroxyethyl)amino)propyl)-1H-indol-7-








yl)oxy)-[CAS]







AJG-049


WO
9733885
Gastroprokinetic
Motility dysfunction, 








GI, general


Ajmaline

12/07/4360






Alacepril

74258-86-9






albaconazole
4(3H)-Quinazolinone, 7-chloro-3-
187949-02-6
WO
9705131
Antifungal
Infection, Candida, 



[(1R,2R)-2-(2,4-difluorophenyl)-2-




general



hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-








yl)propyl]-[CAS]







albendazole
Carbamic acid, [5-(propylthio)-1H-
54029-12-8
GB
1464326
Anthelmintic
Infection, helminth, 



benzimidazol-2-yl]-, methyl ester [CAS]
54965-21-8



general


Albuterol

18559-94-9






Albutoin

830-89-7






alclofenac
Benzeneacetic acid, 3-chloro-4-(2-
22131-79-9
GB
1174535
Anti-inflammatory




propenyloxy)-[CAS]







alclometasone
Pregna-1,4-diene-3,20-dione, 7-chloro-
66734-13-2
U.S.
4,124,707
Antipruritic/inflamm, 
Inflammation, dermal



11-hydroxy-16-methyl-17,21-bis(1-
67452-97-5


allergic




oxopropoxy)-, (7Alpha,11β,16Alpha)-








[CAS]







Alcuronium

23214-96-2






Aldioxa

5579-81-7






Aldol

107-89-1






Aldosterone

52-39-1






alendronate
Phosphonic acid, (4-amino-1-
121268-17-5
GB
2118042
Osteoporosis treatment
Osteoporosis



hydroxybutylidene)bis-[CAS]
129318-43-0






Alendronic 

66376-36-1






Acid








Alexidine

22573-93-9






alfacalcidol
9,10-Secocholesta-5,7,10(19)-triene-
41294-56-8


Osteoporosis treatment
Osteodystrophy



1,3-diol, (1Alpha,3β,5Z,7E)-[CAS]







Alfadolone

23930-37-2






Alfaxalone

23930-19-0






Alfentanil

71195-58-9






alfimeprase

259074-76-5


Fibrinolytic
Peripheral vascular 








disease


alfuzosin
2-Furancarboxamide, N-[3-[(4-amino-
81403-68-1
GB
2013679
Prostate disorder
Benign prostatic 



6,7-dimethoxy-2-




hyperplasia



quinazolinyl)methylamino]propyl]tetra-








hydro-[CAS]
81403-80-7






alfuzosin
2-Furancarboxamide, N-[3-[(4-amino-
81403-68-1


Formulation, modivied-
Benign prostatic 



6,7-dimethoxy-2-
81403-80-7


release, other
hyperplasia



quinazolinyl)methylamino]propyl]tetra-








hydro-[CAS]







Algestone

595-77-7






Algestone 

24356-94-3






Acetophenide








Algin

9005-38-3






Alglucerase

143003-46-7






Alibendol

26750-81-2






aliskiren
(2S,4S,5S,7S)-5-Amino-N-(2-
173334-57-1


Antihypertensive, renin 
Hypertension, general



carbamoyl-2-methylpropyl)-4-hydroxy-2-



system




isopropyl-7-[4-methoxy-3-(3-








methoxypropoxy)benzyl]-8-








methylnonanamide







alitretinoin
9-cis retinoic acid
03/08/5300


Antipruritic/inflamm, 
Eczema, general







allergic



alizapride
1H-Benzotriazoie-5-carboxamide, 6-
59338-93-1
GB
1475234
Antiemetic
Nausea and



methoxy-N-[[1-(2-propenyl)-2-




vomiting, general



pyrrolidinyl)methyl]-[CAS]







Alkannin

517-88-4






Alkofanone

7527-94-8






Allantoin

97-59-6






Allobarbital

52-43-7






Allopurinol

315-30-0






Allyl 

57-06-7






Isothiocyanate








Allylestrenol

432-60-0






almagate
Magnesium, [carbon-
66827-12-1
U.S.
4,447,417
Antacid/Antiflatulent




ato(2-)]heptahydroxy(aluminum)tri-,
72526-11-5







dihydrate [CAS]







alminoprofen
Benzeneacetic acid, Alpha-methyl-4-[(2-
39718-89-3
U.S.
3,957,850
Analgesic, NSAID




methyl-2-propenyl)amino]-[CAS]







almitrine
1,3,5-Triazine-2,4-diamine, 6-[4-[bis(4-
27469-53-0
GB
1256513
Respiratory




fluorophenyl)methyl]-1-piperazinyl]-N,N′
29608-49-9







di-2-propenyl-, dimethanesulfonate








[CAS]







almotriptan
Pyrrolidine, 1-(((3-(2-
154323-57-6
WO
9402460
Antimigraine
Migraine



(dimethylamino)ethyl)-1H-indol-5-








yl)methyl)sulfonyl)-[CAS]







Aloe-

481-72-1






Emodin








Aloin

5133-19-7






alosetron
2,3,4,5-Tetrahydro-5-methyl-2-[(5-
122852-42-0
EP
306323
GI inflammatory/bowel 
Irritable bowel 



methyl-1H-imidazol-4-yl)methyl]-1H-
122852-69-1


disorders
syndrome



pyrido[4,3-b]indol-1-one [CAS]
132414-02-9






alovudine
Thymidine, 3′-deoxy-3′-fluoro-[CAS]
25526-93-6
EP
470355
Antiviral, anti-HIV
Infection, HIV/AIDS


Aloxiprin

9014-67-9






Alpha-1 


U.S.
5,780,014
Formulation, inhalable, 
Emphysema, alpha-1


protease 








inhibitor




topical
antitrypsin deficiency


Alpha-
Ergocryptine, 9,10-dihydro-
29261-93-6


Formulation, other
Parkinson's disease


dihydroer-
methanesulfonate (salt)-[CAS]







gocryptine








Alphaprodine

77-20-3






Alpidem

82626-01-5






Alpiropride

81982-32-3






alprazolam
4H-[1,2,4]Triazolo[4,3-
28981-97-7
U.S.
3,987,052
Anxiolytic
Anxiety, general



al][1,4]benzodiazepine, 8-chloro-1-








methyl-6-phenyl-[CAS]







Alprenolol

13655-52-2






alsactide
Alpha1-17-Corticotropin, 1-β-alanine-
34765-96-3
U.S.
3,749,704
ACTH
Arthritis, rheumatoid



17-[N-(4-aminobutyl)-L-lysinamide]-








[CAS]







ALT-711
Thiazolium, 4,5-dimethyl-3-(2-oxo-2-
181069-80-7
WO
9622095
Symptomatic 
Hypertension, general



phenylethyl)-, bromide [CAS]



antidiabetic



Althiazide

5588-16-9






altinicline
Pyridine, 3-ethynyl-5-((2S)-1-methyl-2-
179120-92-4
U.S.
5,594,011
Antiparkinsonian
Parkinson's disease



pyrrolidinyl)-[CAS]







altretamine
1,3,5-Triazine-2,4,6-triamine,
645-05-6
U.S.
3,424,752
Anticancer, alkylating
Cancer, ovarian



N,N,N′,N′,N′′,N′′-hexamethyl-[CAS]







aluminium 
Aluminium chloride, hexahydrate
7446-70-0


Dermatological
Hyperhidrosis


chloride








hexahydrate

7784-13-6






Aluminon

569-58-4






Aluminum 

8006-13-1






Acetate 








Solution








Aluminum 

15477-33-5






Chlorate








Aluminum 

1327-41-9






Hydroxy-








chloride








Aluminum 

10043-67-1






Potassium 








Sulfate








Aluminum 

10102-71-3






Sodium 








Sulfate








alusulf
Aluminum hydroxide sulfate
61115-28-4
DE
2510663
Urological
Hyperphosphataemia



(Al7(OH)17(SO4)2), dodecahydrate








[CAS]







Alverine

150-59-4






alvimopan
Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-
156053-89-3
EP
657428
GI inflammatory/bowel 
Ileus



hydroxyphenyl)-3,4-dimethyl-1-



disorders




piperidinyl]methyl]-1-oxo-3-








phenylpropyl]-[CAS]







alvocidib
4H-1-Benzopyran-4-one, 2-(2-
131740-09-5


Anticancer, other
Cancer, renal



chlorophenyl)-5,7-dihydroxy-8-(3-
146426-40-6







hydroxy-1-methyl-4-piperidinyl)-, cis-(−)-








[CAS]







ALX-0646


WO
9506638
Antimigraine
Migraine


AM-24
2,4,6-Triiodophenol
609-23-4


GI inflammatory/
Crohn's disease







bowel disorders



AM-36
1-Piperazineethanol, 4-[[3,5-bis(1,1-
199467-52-2


Neuroprotective
Unspecified



dimethylethyl)-4-hydroxyphenyl]methyl]-








Alpha-(4-chlorophenyl)-[CAS]







AM-477
2-Methoxyoestradiol



Antiasthma
Asthma


Amantadine

768-94-5






amantanium
1-Decanaminium, N,N-dimethyl-N-[2-
58158-77-3
U.S.
4,288,609
Antifungal
Infection, general



[(tricyclo[3.3.1.13,7]dec-1-








ylcarbonyl)oxy]ethyl]-, bromide [CAS]







Ambazone

539-21-9






Ambenonium

115-79-7






ambrisentan
(+)-(2S)-2-[(4,6-dimethylpyrimidin-2-
177036-94-1


Vasodilator, peripheral
Heart failure



yl)oxy]-3-methoxy-3,3-








diphenylpropanoic acid







ambroxol
Cyclohexanol, 4-[[(2-amino-3,5-
23828-92-4
GB
1178034
COPD treatment
Bronchitis, chronic



dibromophenyl)methyl]amino]-,
18683-91-5







trans-[CAS]







Ambucaine

119-29-9






Ambuphylline

5634-34-4






Ambuside

3754-19-6






Ambutonium 

115-51-5






Bromide








amcinonide
Pregna-1,4-diene-3,20-dione, 21-
51022-69-6
DE
2437847
Antipsoriasis




(acetyloxy)-16,17-








[cyclopentylidenebis(oxy)]-9-fluoro-11-








hydroxy-, (11β, 16Alpha)-[CAS]







AMD-3100
1,4,8,11-Tetraazacyclotetradecane,
155148-31-5
U.S.
5,612,478
Haematological
Chemotherapy-



1,11-(1,4-phenylenebis(methylene))bis-,




induced injury,



octahydrochloride [CAS]




bone marrow,








leocopenia


Amdinocillin

32887-01-7






Amdinociiiin 

32886-97-8






Pivoxil








amdoxovir
1,3-Dioxolane-2-methanol, 4-(2,6-
145514-04-1
EP
656778
Antiviral, anti-HIV
Infection, HIV/AIDS



diamino-9H-purin-9-yl)-(2R-cis)-[CAS]







amelubant
Carbamic acid, ((4-((3-((4-(1-(4-
346735-24-8
DE
10000907
COPD treatment
Chronic obstructive



hydroxyphenyl)-1-




pulmonary disease



methylethyl)phenoxy)methyl)phen-








yl)methoxy)phenyl)iminomethyl)-ethyl 








ester [CAS]







Americaine
Benzenemethanaminium, N,N-dimethyl-
129128-13-8


Formulation, inhalable, 
Pain, general



N-[2-[2-[4-(1,1,3,3-



other




tetramethylbutyl)phenoxy]ethoxy]ethyl]-,








chloride, mixt. with ethyl 4-








aminobenzoate [CAS]







Amezinium

30578-37-1






Amfenac

51579-82-9






Amidephrine

3354-67-4






Amidinomycin

3572-60-9






amifostine
Ethanethiol, 2-[(3-aminopropyl)amino]-,
20537-88-6
EP
131500
Radio/chemoprotective
Chemotherapy-



dihydrogen phosphate (ester)-[CAS]
63717-27-1



induced injury, 








renal


amiglumide
Pentanoic acid, 5-(dipentylamino)-4-((2-
119363-62-1
WO
8805774
GI inflammatory/
Pancreatitis



naphthalenylcarbonyl)amino)-5-oxo-



bowel disorders




(R)-[CAS]







amikacin

37517-28-5


Formulation, optimized,
Infection, general




39831-55-5


microencapsulate



Amiloride

2609-46-3






Aminacrine

90-45-9






amineptine
Heptanoic acid, 7-[(10,11-dihydro-5H-
30272-08-3
U.S.
3,758,528
Antidepressant




dibenzo[a,d]cyclohepten-5-yl)amino]-
57574-09-1







[CAS]







Aminitrozole

140-40-9






Amino Acid 








Preparations








Aminocaproic 








Acid








amino-
2,6-Piperidinedione, 3-(4-aminophenyl)-
125-84-8
U.S.
3,944,671
Anticancer, hormonal
Cancer, breast


glutethimide
3-ethyl-[CAS]







Aminoguanidine
79-17-4







Aminohippurate








Aminometradine

642-44-4






Aminopentamide

60-46-8






aminophylline
1H-Purine-2,6-dione, 3,7-dihydro-1,3-
317-34-0


Formulation, modified-
Asthma



dimethyl-, compd. with 1,2-



release, other




ethanediamine (2:1) [CAS]







Aminopromazine

58-37-7






Aminopyrine

58-15-1






Aminoquinuride

3811-56-1






Aminorex

2207-50-3






amiodarone
Methanone, (2-butyl-3-benzofuranyl)[4-
1951-25-3
U.S.
3,248,401
Antiarrhythmic
Arrhythmia, general



[2-(diethylamino)ethoxy]-3,5-
19774-82-4







diiodophenyl]-[CAS]







Amiphenazole

490-55-1






Amiprilose

56824-20-5






amisulpride
Benzamide, 4-amino-N-[(1-ethyl-2-
71675-85-9
U.S.
4,401,822
Neuroleptic
Schizophrenia



pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-








methoxy-[CAS]







Amitriptyline

50-48-6






amitriptyline + 
1-Propanamine,3-(10,11-dihydro-5H-



Formulation, fixed-dose
Pain, neuropathic


ketamine
dibenzo[a,d]cyclohepten-5-ylidene)-



combinations




N,N-dimethyl + cyclohexanone,2-(2-








chlorophenyl)-2-(methylamino)







Amitriptylin-

4317-14-0






oxide








amlexanox
5H-[1]Benzopyrano[2,3-b]pyridine-3-
68302-57-8
U.S.
4,299,963
Antiasthma
Asthma



carboxylic acid, 2-amino-7-(1-








methylethyl)-5-oxo-[CAS]







amlodipine
3,5-Pyridinedicarboxylic acid, 2-[(2-
111470-99-6
EP
89167
Antianginal
Hypertension, general



aminoethoxy)methyl]-4-(2-
88150-42-9







chlorophenyl)-1,4-dihydro-6-methyl-, 3-
88150-47-4







ethyl 5-methyl ester [CAS]







Ammoniacum

03/07/9000






Ammonium 

1863-63-4






Benzoate








Ammonium 

530-31-4






Mandelate








Ammonium 

528-94-9






Salicylate








Ammonium 

42739-38-8






Valerate








Amobarbital

57-43-2






Amocarzine

36590-19-9






Amodiaquin

86-42-0






amorolfine
Morpholine, 4-[3-[4-(1,1-
78613-35-1
EP
24334
Antifungal
Infection, fungal, 



dimethylpropyl)phenyl]-2-methylpropyl]-
78613-38-4



general



2,6-dimethyl-, cis-[CAS]







Amoscanate

26328-53-0






amosulalol
Benzenesulfonamide, 5-[1-hydroxy-2-
70958-86-0
EP
136103
Antihypertensive, 
Hypertension, general



[[2-(2-
85320-68-9


adrenergic




methoxyphenoxy)ethyl]amino]ethyl]-2-








methyl-, (+/−)-[CAS]







Amotriphene

5585-64-8






amoxapine
Dibenz[b,f][1,4]oxazepine, 2-chloro-11-
14028-44-5
GB
1192812
Antidepressant
Depression, general



(1-piperazinyl)-[CAS]







amoxicillin
4-Thia-1-azobicyclo[3,2,0]heptane-2-
26787-78-0


Formulation, modified-
Infection, general



carboxylic acid, 6-[[amino(4-
61336-70-7


release, other




hydroxyphenyl)acetyl]amino]-3,3-








dimethyl-7-oxo-,[2S-








[2Alpha,5Alpha,6β(S*)]] [CAS]







amoxicillin + 

74469-00-4
GB
1508977
Formulation, fixed-dose
Infection, respiratory 


potassium 




combinations
tract, general


clavulan








AMPAlex
Piperidine, 1-(6-quinoxalinylcarbonyl)-
154235-83-3
U.S.
5,650,409
Psychostimulant
Attention deficit 



[CAS]




disorder


Amphetamine

300-62-9






Amphetaminil

17590-01-1






amphotericin 
Amphotericin B compd. with (3β)-
120895-52-5
U.S.
4,822,777
Formulation, optimized, 
Infection, general


B
cholest-5-en-3-yl hydrogen sulfate (1:1)
1397-89-3


liposomes




[CAS]







ampicillin
4-Thia-1-azabicyclo[3.2.0]heptane-2-
69-53-4


Formulation, fixed-dose
Infection, general



carboxylic acid, 6-
7177-48-2


combinations




[(aminophenylacetyl)amino]-3,3-








dimethyl-7-oxo-, [2S-








[2Alpha,5Alpha,6β(S*)]]







Ampirox-

99464-64-9






icam








Ampligen

38640-92-5






amprenavir
Carbamic acid, (3-(((4-
161814-49-9
U.S.
5,783,701
Antiviral, anti-HIV
Infection, HIV/AIDS



aminophenyl)sulfonyl)(2-








methylpropyl)amino)-2-hydroxy-1-








(phenylmethyl)propyl)-, tetrahydro-3-








furanyl ester, (3S-(3R*(1R*,2S*)))-








[CAS]







amrinone
[3,4′-Bipyridin]-6(1H)-one, 5-amino-
60719-84-8
U.S.
4,004,012
Cardiostimulant




[CAS]
75898-90-7






amrubicin
5,12-Naphthacenedione, 9-acetyl-9-
92395-36-3
EP
107486
Anticancer, antibiotic
Cancer, lung, 



amino-7-[(2-deoxy-β-D-erythro-




non-small cell



pentopyranosyl)oxy]-7,8,9,10-








tetrahydro-6,11-dihydroxy-,








hydrochloride, (7S-cis)-[CAS]







amsacrine
Methanesulfonamide, N-(4-(9-
51264-14-3


Anticancer, other
Cancer, leukaemia, 



acridinylamino)-3-methoxyphenyl]-




acute lymphocytic



[CAS]







amtolmetin 
Glycine, N-[[1-methyl-5-(4-
87344-06-7
GB
2115417
Analgesic, NSAID
Arthritis, rheumatoid


guacil
methylbenzoyl)-1H-pyrrol-2-yl]acetyl]-,








2-methoxyphenyl ester [CAS]







Amylocaine

532-59-2






AN-152


WO
9719954
Anticancer, antibiotic
Cancer, prostate


anabolic 


WO
9848812
Cardiovascular
Heart failure


steroids








Anagestone

2740-52-5






anagrelide
Imidazo[2,1-b]quinazolin-2(3H)-one,
58579-51-4
GB
1418822
Haematological
Thrombocytosis



6,7-dichloro-1,5-dihydro-,
68475-42-3







monohydrochloride [CAS]







anastrozole
1,3-Benzenediacetonitrile,
120511-73-1
EP
296749
Anticancer, hormonal
Cancer, breast



Alpha,Alpha,Alpha,Alpha′-tetramethyl-5-








(1H-1,2,4-triazol-1-ylmethyl)-[CAS]







Anazolene

3861-73-2






Ancitabine

31698-14-3






Ancrod

9046-56-4






andolast
N-4′-[5-Tetrazolyl]-phenyl-4-(5-
132640-22-3
EP
460083
Antiasthma
Asthma



tetrazolyl)-benzamide







Androisoxazole

360-66-7






Androstenediol

521-17-5






anecortave
21-(Acetyloxy)-17-hydroxypregna-
7753-60-8


Ophthalmological
Macular 



4,9(11)-diene-3,20-dione




degeneration


Anethole

4180-23-8;








104-46-1








(unspecified)






Anethole 

532-11-6






Trithione








Angiogenix


U.S.
6,417,205
Cardiovascular
Cardiomyopathy, 








ischaemic


Angiotensin

1407-47-2






anhydro-
Vincaleukoblastine, 3′,4′-didehydro-4′-
38390-45-3
U.S.
6,011,041
Anticancer, other
Cancer, general


vinblastine
deoxy-[CAS]







anidulafungin
Echinocandin B, 1-((4R,5R)-4,5-
166663-25-8
U.S.
6,384,013
Antifungal
Infection, Candida, 



dihydroxy-N2-((4′′-(pentyloxy)(1,1′:4′,1′′-




general



terphenyl)-4-yl)carbonyl)-L-ornithine)-








[CAS]







Anileridine

144-14-9






Aniracetam

72432-10-1






Anisindione

117-37-3






Anisomycin

22862-76-6






Anisotropine 

80-50-2






Methylbromide








anistreplase
Anistreplase [CAS]
81669-57-0
EP
28489
Fibrinolytic
Infarction, myocardial


Antazoline

91-75-8






Anthiolimine

305-97-5






Anthralin

1143-38-0






Anthramycin

4803-27-4






Anthrarobin

577-33-3






anthrax 


U.S.
6,436,933
Anti-infective, other
Infection, anthrax


inhibitor








antiangiogenic 


U.S.
6,426,067
Anticancer, other
Cancer, general


dendrimers








Anticort
L-Ascorbic acid, mixt with 2-
186646-39-9
WO
9640038
Anabolic
Cachexia



(diethylamino)ethyl 4-aminobenzoate








monohydrochloride, disodium








hydrogen phosphate, potassium








benzoate and zinc sulfate (1:1) [CAS]







antidepressants


U.S.
5,898,036
Antidepressant
Depression, general


anti-invasins


U.S.
6,303,302
Antifungal
Infection, fungal, 








general


Antimony 

28300-74-5






Potassium 








Tartrate








Antimony 

539-54-8






Sodium








Thioglycollate








Antimony 

6533-78-4






Thioglycoll-








amide








Antiprogestin
19-Norpregna-4,9-dien-3-
211254-73-8
DE
19706061
Anticancer, hormonal
Cancer, breast



one,(acetylphenyl)-20,20,21,21,21-








pentafluoro-17-hydroxy-(11β,17Alpha)








[CAS]







Antipyrine

60-80-0






Antipyrine 

520-07-0






Salicylate








antithrombin III
Antithrombin, III [CAS]
9000-94-6


Blood fraction
Antithrombin III 




90170-80-2



deficiency


anxiolytics


U.S.
5,756,538
Anxiolytic
Anxiety, general


AP-521
N-Piperonyl-2-amino-1,2,3,4-
151227-08-6
WO
9321189
Anxiolytic
Anxiety, general



tetrahydrobenzo(b)thieno(2,3-








c)pyridine-3-carbamide







AP-5280


U.S.
5,965,118
Anticancer, alkylating
Cancer, general


Apalcillin

63469-19-2






apaziquone
1H-Indole-4,7-dione, 5-(1-aziridinyl)-3-
114560-48-4
WO
8706227
Anticancer, alkylating
Cancer, breast



(hydroxymethyl)-2-(3-hydroxy-1-








propenyl)-1-methyl-, (E)-[CAS]







Apazone

13539-59-8






a-Phenyl-

90-26-6






butyramide








Apocodeine

641-36-1






apomine
Phosphonic acid, (2-(3,5-bis(1,1-
126411-13-0


Anticancer, other
Cancer, prostate



dimethylethyl)-4-








hydroxyphenyl)ethylidene)bis-








tetrakis(1-methylethyl) ester [CAS]







apomorphine
4H-Dibenzo[de,g]quinoline-10,11-diol,
314-19-2


Formulation, 
Impotence



5,6,6a,7-tetrahydro-6-methyl-,
58-00-4


transmucosal, 




hydrochloride



nasal



apraclonidine
1,4-Benzenediamine, 2,6-dichloro-N1-
66711-21-5
U.S.
4,517,199
Antiglaucoma
Glaucoma



(4,5-dihydro-1H-imidazol-2-yl)-[CAS]
73218-79-8






aprepitant
3H-1,2,4-Triazol-3-one, 5-[[(2R,35)-2-
170729-80-3
U.S.
5,719,147
Antiemetic
Chemotherapy-



[(1R)-1-[3,5-




induced nausea 



bis(trifluoromethyl)phenyl]ethoxy]-3-(4-




and vomiting



fluorophenyl)-4-morpholinyl]methyl]-1,2-








dihydro-[CAS]







aprindine
1,3-Propanediamine, N-(2,3-dihydro-
33237-74-0
GB
1321424
Antiarrhythmic




1H-inden-2-yl)-N′,N′-diethyl-N-phenyl-
37640-71-4







[CAS]







Aprobarbital

77-02-1






Apronalide

528-92-7






Aprotinin

9087-70-1






Aptiganel

137159-92-3






AQ4N
9,10-Anthracenedione, 1,4-bis((2-
136470-65-0
U.S.
5,132,327
Anticancer, other
Cancer, general



(dimethyloxidoamino)ethyl)amino)-5,8-








dihydroxy-[CAS]







Aquavan


U.S.
6,204,257
Anaesthetic, injectable
Anaesthesia


AR-116081


U.S.
6,107,324
Neuroleptic
Unspecified


AR-A2
(R)-N-[5-methyl-8-(4-methylpiperazin-1-



Anxiolytic
Anxiety, general



yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-








morpholinobenzamide







Arachidonic 

506-32-1






Acid








aranidipine
3,5-Pyridinedicarboxylic acid, 1,4-
86780-90-7
GB
2111978
Antihypertensive, other
Hypertension, general



dihydro-2,6-dimethyl-4-(2-nitrophenyl)-,








methyl 2-oxopropyl ester-[CAS]







arbekacin
D-Streptamine, O-3-amino-3-deoxy-
51025-85-5
U.S.
4,001,208
Aminoglycoside 
Infection, general



Alpha-D-glucopyranosyl-(1-6)-O-[2,6-
75282-65-4


antibiotic




diamino-2,3,4,6-tetradeoxy-Alpha-D-








erythro-hexopyranosyl-(1-4)]-N1-(4-








amino-2-hydroxy-1-oxobutyl)-2-deoxy-,








(S)-[CAS]







Arbidol
1H-indole-3-carboxylic acid, 6-bromo-4
131707-23-8
WO
9008135
Immunostimulant, other
Infection, influenza 



((dimethylamino)methyl)-5-hydroxy-1-




virus



methyl-2-((phenylthio)methyl)-,








ethylester, monohydrochloride [CAS]







arbutamine
1,2-Benzenediol, 4-[1-hydroxy-2-[[4-(4-
128470-16-6
WO
9220324
Diagnostic
Diagnosis, coronary



hydroxyphenyl)butyl]amino]ethyl]-, (R)-








[CAS]







Arcitumomab

154361-48-5






ardeparin
Heparin [CAS]
9005-49-6


Anticoagulant
Thrombosis, venous


arecoline
1,2,5,6-Tetrahydro-1-methyl-3-pyridine



Formulation, 
Alzheimer's disease



carboxylic acid methyl ester



transdermal, patch



argatroban
2-Piperidinecarboxylic acid, 1-[5-
74863-84-6
EP
8746
Anticoagulant
Thrombosis, arterial



[(aminoiminomethyl)amino]-1-oxo-2-








[[(1,2,3,4-tetrahydro-3-methyl-8-








quinolinyl)sulfonyl]amino]pentyl]-4-








methyl-[CAS]







Arginine

74-79-3






Ariflo ®

153259-65-5






aripiprazole
2(1H)-Quinolinone, 7-[4-[4-(2,3-
129722-12-9
EP
367141
Neuroleptic
Schizophrenia



dichlorophenyl)-1-piperazinyl]butoxy]








3,4-dihydro-[CAS]







arofylline
1H-Purine-2,6-dione, 3-(4-
136145-07-8
EP
435811
COPD treatment
Chronic obstructive



chlorophenyl)-3,7-dihydro-1-propyl-




pulmonary disease



[CAS]







arotinolol
2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-
104766-23-6
U.S.
3,932,400
Antihypertensive, 
Hypertension, general



dimethylethyl)amino]-2-
68377-92-4


adrenergic




hydroxypropyl]thio]-4-thiazolyl]-, (±)-








[CAS]







Arsacetin

618-22-4






arsenic trioxide
Arsenic oxide (As2O3) [CAS]
1327-53-3


Anticancer, other
Cancer, leukaemia, 








acute myelogenous


Arsphenamine

139-93-5






Arsthinol

119-96-0






Arteether

75887-54-6






Arteflene

123407-36-3








(Z-form)






Artemether

71963-77-4






Artemisinin

63968-64-9






artemotil
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-
75887-54-6


Antimalarial
Infection, malaria



benzodioxepin, 10-ethoxydecahydro-








3,6,9-trimethyl-, [3R-








(3Alpha,5aβ,6β,8aβ,9aAlpha,10Alpha,








12+62,12aR*)]-[CAS]







artesunate
Butanedioic acid mono-
88495-63-0


Formulation, 
Infection, malaria



[(3R,5aS,6R,8aS,9R,10R,12R,12aR)-



transmucosal,




decahydro-3,6,9-trimethyl-3,12-epoxy-



systemic




12H-pyrano[4,3-j]-1,2-benzodioxepin-








10-yl]ester







arzoxifene
Benzo(b)thiophene-6-ol,2-(4-
182133-27-3
WO
9609041
Anticancer, hormonal
Cancer, breast



methoxyphenyl)-3-(4-(2-(1-








piperidinyl)ethoxy)phenoxy)-[CAS]







AS-3201
Spiro(pyrrolidine-3,4′(1′H)-pyrrolo(1,2-
147254-64-6
EP
520320
Symptomatic 
Diabetic 



a)pyrazine)-1′,2,3′,5(2′H)-tetrone, 2′-((4-



antidiabetic
complication,



bromo-2-fluorophenyl)methyl)-, (3′R)-




general



[CAS]







ASA
Benzoic acid, 2-(acetyloxy)-[CAS]
50-78-2


Formulation, modified-
Pain, general




56449-07-1


release, other



a-Santonin

481-06-1






Ascaridole

512-85-6






Ascorbic 

50-81-7






Acid








asenapine
1H-Dibenz[2,3:6,7]oxepino[4,5-
85650-56-2
WO
9523600
Neuroleptic
Psychosis, general



c]pyrrole, 5-chloro-2,3,3a,12b-








tetrahydro-2-methyl-, trans-, (Z)-2-








butenedioate (1:1) [CAS]







asimadoline
Benzeneacetamide, N-[2-(3-hydroxy-1-
153205-46-0
DE
4215213
GI inflammatory/bowel 
Irritable bowel 



pyrrolidinyl)-1-phenylethyl]-N-methyl-



disorders
syndrome



Alpha-phenyl-, [S-(R*,R*)]-[CAS]







asoprisnil
11β-[4-(Hydroxyiminomethyl)phenyl]-
199396-76-4
EP
0648778
Menstruation disorders
Endometriosis



17β-methoxy-17Alpha-








(methoxymethyl)estra-4,9-dien-3-one







Asoxime

34433-31-3






Aspartic Acid

56-84-8






Aspidin

584-28-1






Aspidinol

519-40-4






Aspirin

50-78-2






Aspirin, 








Dipyridamole








aspoxicillin
Glycinamide, N-methyl-D-asparaginyl-
63358-49-6
GB
1533413
Penicillin, injectable
Infection, respiratory 



N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-




tract, general



1-azabicyclo[3.2.0]hept-6-yl)-D-2-(4-








hydroxyphenyl)-, [2S-








(2Alpha,5Alpha,6β)]-[CAS]







AST-120
AST 120 [CAS]
90597-58-3


Urological
Renal failure


Astemizole

68844-77-9






asulacrine
4-Acridinecarboxamide, 9-[[2-methoxy-
80841-47-0
EP
39224
Anticancer, other
Cancer, general



4-[(methylsulfonyl)amino]phenyl]amino]-
80841-48-1







N,5-dimethyl-[CAS]







AT-1015
(N-[2-[4-(5H-Dibenzo[a,d]cyclohepten-



Antithrombotic
Thrombosis, general



5-ylidene)-piperdino]ethyl]-1-formyl-4-








piperidinecarboxamide








monohydrochioride monohydrate







atamestane
Androsta-1,4-diene-3,17-dione, 1-
96301-34-7
DE
3338212
Anticancer, hormonal
Cancer, breast



methyl-[CAS]







atazanavir
2,5,6,10,13-Pentaazatetradecanedioic








acid, 3,12-bis(1,1-dimethylethyl)-8-








hydroxy-4,11-dioxo-9-(phenylmethyl)-6-
229975-97-7


Antiviral, anti-HIV
Infection, HIV/AIDS



((4-(2-pyridinyl)phenyl)methyl)-








dimethyl ester, (3S,8S,9S,12S)-,








sulfate (1:1) (salt) [CAS]







atenolol
Benzeneacetamide, 4-[2-hydroxy-3-[(1-
29122-68-7
GB
1285038
Antihypeertensive, 
Hypertension, general



methylethyl)amino]propoxy]-[CAS]
73677-19-7


adrenergic



atenolol + 
Benzeneacetamide, 4-[2-hydroxy-3-[(1-







chlorthalidone
methylethyl)amino]propoxy]-, mixt. with








2-chloro-5-(2,3-dihydro-1-hydroxy-3-
73677-19-7
U.S.
3,836,671
Formulation, fixed-dose
Hypertension, general



oxo-1H-isoindol-1-



combinations




yl)benzenesulfonamide [CAS]







atenolol + 
Benzeneacetamide, 4-[2-hydroxy-3-[(1-



Formulation, fixed-dose
Hypertension, general


nifedipine
methylethyl)amino]propoxy]- + 4-(2′-



combinations




nitrophenyl)-2,6-dimethyl-3,5-








dicarbomethoxy-1,4-dihydropyridine







a-Terpineol

98-55-5






Atevirdine

136816-75-6






atipamezole
1H-Imidazole, 4-(2-ethyl-2,3-dihydro-
104054-27-5
EP
183492
Reproductive/gonadal, 
Sexual dysfunction, 



1H-inden-2-yl)-[CAS]



general
female


atiprimod 
2-Azaspivo[4.5]decane-2-
130065-61-1
U.S.
5,744,495
Antiarthritic, 
Arthritis, rheumatoid


dimaleate
propanamine, N,N-diethyl-8,8-dipropyl,



immunological




dimaleate







ATL-146e


U.S.
6,232,297
Imaging agent
Unspecified


a-Tocopherol

59-02-9






atomoxetine
Benzenepropanamine, N-methyl-
82248-59-7
EP
52492
Neurological
Attention deficit 



Gamma-(2-methylphenoxy)-, (R)-
83015-26-3



disorder



[CAS]







atorvastatin
1H-Pyrrole-1-heptanoic acid, 2-(4-








fluorophenyl)-β,delta-dihydroxy-5-(1-
134523-03-8
EP
409281
Hypolipaemic/
Hypercholesterol-



methylethyl)-3-phenyl-4-
134523-00-5


Antiatherosclerosis
aemia



[(phenylamino)carbonyl]-[CAS]







atosiban
Oxytocin, 1-(3-mercaptopropanoic
90779-69-4 
EP
112809
Labour inhibitor
Labour, preterm



acid)-2-(O-ethyl-D-tyrosine)-4-L-








threonine-8-L-ornithine-[CAS]







atovaquone
1,4-Naphthalenedione, 2-[4-(4-
95233-18-4
EP
123238
Antifungal
Infection, 



chlorophenyl)cyclohexyl]-3-hydroxy-,




Pneumocystis



trans-[CAS]




jiroveci


atovaquone + 
1,4-Naphthalenedione,2-[4-(4-



Antimalarial
Infection, malaria


proguanil
chlorophenyl)cyclohexyl]-3-hydroxy-,








trans + N-(4-chloro-phenyl)-N-(1-








methylethyl)imidiodicarbonimidic








diamide







atracurium
Isoquinolinium, 2,2′-[1,5-
64228-81-5
U.S.
4,179,557
Muscle relaxant
Surgery adjunct



pentanediylbis[oxy(3-oxo-3,1-








propanediyl)]]bis[1-[(3,4-








dimethoxyphenyl)methyl]-1,2,3,4-








tetrahydro-6,7-dimethoxy-2-methyl-








[CAS]







atrasentan
3-Pyrrolidinecarboxylic acid, 4-(1,3-
173937-91-2
WO
9730045
Anticancer, other
Cancer, prostate



benzodioxol-5-yl)-1-[2-(dibutylamino)-2-








oxoethyl]-2-(4-methoxyphenyl)-,








(2R,3R,4S)-[CAS]







Atrial 

85637-73-6






Natriuretic 








Peptide








Atrolactamide

2019-68-3






Atropine

51-55-8






Augmentin

74469-00-4


Formulation. modified-
Infection, respiratory 







release, other
tract, general


auranofin
Gold, (1-thio-β-D-glucopyranose
34031-32-8
U.S.
3,708,579
Antiarthritic, other
Arthritis, rheumatoid



2,3,4,6-tetraacetato-








S)(triethylphosphine)-[CAS]







Aurothio-

12192-57-3






glucose








avasimibe
Sulfamic acid, [[2,4,6-tris(1-
166518-60-1
U.S.
5,491,172
Hypolipaemic/
Atherosclerosis



methylethyl)phenyl]acetyl]-, 2,6-bis(1-



Antiatherosclerosis




methylethyl)phenyl ester [CAS]







Avobenzone

70356-09-1






AWD-12-281
AWD 12-281 [CAS]
257892-33-4


Antiallergic, non-asthma
Rhinitis, allergic, 








general


Azacitidine

320-67-2






Azacyclonol

115-46-8






azanidazole
2-Pyrimidinamine, 4-[2-(1-methyl-5-
62973-76-6
U.S.
3,882,105
Antibacteria, other
Infection, 



nitro-1H-imidazol-2-yl)ethenyl]-,(E)-




trichomoniasis



[CAS]







azapropazone
1H-Pyrazolo[1,2-a][1,2,4]benzotriazine-
13539-59-8
FR
1440629
Anti-inflammatory




1,3(2H)-dione, 5-(dimethylamino)-9-








methyl-2-propyl-[CAS]







Azaserine

115-02-6






azasetron
2H-1,4-Benzoxazine-8-carboxamide, N-
123040-16-4
EP
313393
Antiemetic
Nausea and vomiting



1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-
123040-94-8



general



dihydro-4-methyl-3-oxo-,
123040-96-0







monohydrochioride-[CAS]
123040-69-7






Azatadine

3964-81-6






azathioprine
6-[(1-Methyl-4-nitro-1H-imidazol-5-
446-86-6


Formulation, oral, other
Transplant rejection, 



yl)thio]-1H-purine




bone marrow


AZD-4282
glycine



Analgesic, other
Pain, neuronpathic


AZD-6140
3,4 Difluorophenylcyclopropylamine



Antithrombotic
Thrombosis, arterial


azelaic acid
Nonanedioic acid [CAS]
123-99-9


Antiacne
Acne


azelastine
1(2H)-Phthalazinone, 4-[(4-
58581-89-8
GB
1377231
Antiasthma
Asthma



chlorophenyl)methyl]-2-(hexahydro-1-
79307-93-0







methyl-1H-azepin-4-yl)-,








monohydrochioride [CAS]







azelnidipine
3,5-Pyridinedicarboxylic acid, 2-amino-
123524-52-7
EP
266922
Antihypertensive, other
Hypertension, general



1,4-dihydro-6-methyl-4-(3-nitrophenyl)-,








3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-








methylethyl)ester, (+/−)-[CAS]







Azidamfenicol

13838-08-9






Azidocillin

17243-38-8






Azimilide

149908-53-2






Azintamide

1830-32-6






azithromycin
9-deoxo-9a-aza-9a-methyl-9a-
76801-85-9
U.S.
4,328,334
Macrolide antibiotic
Infection, respiratory 



homoerythromycin-A
83905-01-5



tract, lower




92395-24-9






aziocillin
4-Thia-1-azabicyclo[3.2.0]heptane-2-
37091-65-9
GB
1392849
Penicillin, injectable
Infection, general



carboxylic acid, 3,3-dimethyl-7-oxo-6-
37091-66-0







[[[[(2-oxo-1-








imidazolidinyl)carbonyl]amino]phenyl-








acetyl]amino]-, [2S-








[2.alpha.,5Alpha,6β(S*)]]-[CAS]







Azosemide

27589-33-9






aztreonam
Propanoic acid, 2-[[[1-(2-amino-4-
104184-69-2
GB
2071650
Beta-lactam antibiotic
Infection, general



thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-
78110-38-0







azetidinyl)amino]-2-








oxoethylidene]amino]oxy]-2-methyl-,








[2S-[2Alpha,3β(Z)]]-[CAS]







azulene
Sodium 5-isopropyl-3,8-dimethyl-1-
6223-35-4
EP
88958
Formulation, modified-
Inflammation, general



azulene sulfonate



release, other



bacampicillin
4-Thia-1-azabicyclo[3.2.0]heptane-2-
37661-08-8
GB
1363506
Penicillin, oral
Infection, general



carboxylic acid, 6-
50972-17-3







[(aminophenylacetyl)amino]-3,3-








dimethyl-7-oxo-, 1-








[(ethoxycarbonyl)oxy]ethyl ester, [2S-








[2Alpha,5Alpha,6β(S*)]]-[CAS]







Bacitracin

1405-87-4






baclofen
β-(Aminomethyl)-4-
1134-47-0


Formulation, implant
Spastic paralysis



chlorobenzenepropanoic acid [CAS]







Baicalein

491-67-8






balofloxacin
3-Quinolinecarboxylic acid, 1-
127294-70-6
EP
342675
Quinolone antibacterial
Infection, urinary tract



cyclopropyl-6-fluoro-1,4-dihydro-8-








methoxy-7-[3-(methylamino)-1-








pipendinyl]-4-oxo-[CAS]







balsalazide
Benzoic acid, 5-[[4-[[(2-
80573-04-2
U.S.
4,412,992
GI inflammatory/bowel 
Colitis, ulcerative



carboxyethyl)amino]carbonyl]phenyl]azo]-



disorders




2-hydroxy-, (E)-[CAS]







bambuterol
Carbamic acid, dimethyl-, 5-[2-[(1,1-
81732-46-9
EP
43807
Antiasthma
Asthma



dimethylethyl)amino]-1-hydroxyethyl]-
81732-65-2







1,3-phenylene ester,








monohydrochloride [CAS]







Bamethan

3703-79-5






Bamifylline

2016-63-9






Bamipine

4945-47-5






Barbital

57-44-3






bamidipine
3,5-Pyridinedicarboxylic acid, 1,4-
104713-75-9
U.S.
4,220,649
Antihypertensive, other
Hypertensive, general



dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,
104757-53-1







methyl-1-(phenylmethyl)-3-pyrrolidinyl
71863-56-4







ester, [S-(R*,R*)]-







BAS-118
N-Methyl-3-[2-(2-



Antibacterial, other
Infection, 



napthyl)acetylamino]benzamide




Helicobacter pylori


Basic 

1339-92-0






Aluminum 








Carbonate








Gel








Basiliximab

179045-86-4






Batimastat

130370-60-4






Batroxobin

9039-61-6






Bay-41-2272
5-cyclopropyl-2-[1 (2-fluoro-benzyl)-1H-



Male sexual dysfunction
Sexual dysfunction, 



pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-




male, general



4ylamine







Bay-41-8543
2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-



Cardiovascular
Unspecified



b]pyridin-3-yl]-5-(4-








mopholinyl)pyrimidine-4,6-diamine







BAY-43-9006
N-(4-chloro-3-(trifluoromethyl)phenyl)-



Anticancer, other
Cancer, liver



N′-(4-(2-(N-methylcarbamoyl)-4-








pyridyloxy)phenyl)urea







BAY-57-1293
N-[5(aminosulfonyl)-4-methyl-1,3-



Antiviral, other
Infection, herpes 



thiazol-2-yl]-N-methyl-2-[4-(2-




simplex virus



pyridinyl)phenyl]acetamide







bazedoxifen
TSE 424 [CAS]
198481-33-3
EP
802183
Osteoporosis treatment
Osteoporosis


b-Benzal-

7236-47-7






butyramide








BBR-3464
Platinum(4+), hexaaminedichlorobis(μ-
172903-00-3
U.S.
5,744,497
Anticancer, alkylating
Cancer, lung, 



(1,6-hexanediamine-N:N′))tri-




non-small cell



stereoisomer, tetranitrate [CAS]







BBR-3576


U.S.
5,519,029
Anticancer, antibiotic
Cancer, prostate


BBR-3610


U.S.
6,060,616
Anticancer, alkylating
Cancer, general


b-Carotene

7235-40-7






BCH-1868
(−)-2-R-dihydroxyphosphinyol-5-(S)-



Anticancer, 
Cancer, general



(guanin-9-yl-methyl)tetrahydrofuran



antimetabolite



Bebeerine

477-60-1






Beclamide

501-68-8






beclometasone
Pregna-1,4-diene-3,20-dione, 9-chloro-
5534-09-8
WO
0006132
Formulation, inhalable, 
Asthma



11β,17,21-trihydroxy-16β-methyl,
4419-39-0


solution




[CAS]







Befloxatone

134564-82-2






befunolol
Ethanone, 1-[7-[2-hydroxy-3-[(1-
39543-79-8


Antiglaucoma




methylethyl)amino]propoxy]-2-
39552-01-7







benzofuranyl]-[CAS]







Bemegride

64-65-3






Benactyzine

302-40-9






benazepril
1H-1-Benzazepine-1-acetic acid, 3-[[1-
86541-74-4
EP
72352
Antihypertensive, renin 
Hypertension, general



(ethoxycarbonyl)-3-phenylpropyl]amino]
86541-75-5


system




2,3,4,5-tetrahydro-2-oxo-, [S-(R*,R*)]-
86541-78-8







[CAS]







bencyclane
1-Propanamine, N,N-dimethyl-3-[[1-
14286-84-1
WO
9829409 
Vasodilator, peripheral




(phenylmethyl)cycloheptyl]oxy]-, (E)-2-
2179-37-5







butenedloate (1:1) [CAS]







bendazac
L-Lysine, mono[[[1-(phenylmethyl)-1H-
81919-14-4
GB
2081708
Ophthalmological




indazol-3-yl]oxy]acetate] [CAS]
20187-55-7






Bendro-

73-48-3






flumethiazide








Benexate

78718-25-9






benfluorex
Ethanol, 2-[[1-methyl-2-[3-
23602-78-0
GB
1175516
Hypolipaemic/




(trifluoromethyl)phenyl]ethyl]amino]-,
23642-66-2


Antiatherosclerosis




benzoate (ester) [CAS]







Benfotiamine

22457-89-2






Benfurodil

3447-95-8






benidipine
3,5-Pyridinedicarboxylic acid, 1,4-
105979-17-7
EP
63365
Antihypertensive, other
Hypertension, general



dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,
91599-74-5







methyl 1-(phenylmethyl)-3-piperidinyl








ester, monohydrochloride (R*,R*)-(+/−)-








[CAS]







Benorylate

5003-48-5






Benoxaprofen

67434-14-4






Benoxinate

99-43-4






Benperidol

2062-84-2






Benproperine

2156-27-6






Benserazide

322-35-0






bentazepam
2H-[1]Benzothieno[2,3-e]-1,4-diazepin-
29462-18-8
DE
2005276
Anxiolytic




2-one, 1,3,6,7,8,9-hexahydro-5-








phenyl[CAS]







Bentiromide

37106-97-1






Bentoquatam

1340-69-8






Benzalkonium

8001-54-5






Benzarone

1477-19-6






benzbromarone
Methanone, (3,5-dibromo-4-
3562-84-3
U.S.
3,012,042
Antigout




hydroxyphenyl)(2-ethyl-3-benzofuranyl)








[CAS]







Benzethonium

121-54-0






Benzetimide

14051-33-3






Benzilonium

1050-48-2






Benziodarone

68-90-6






benznidazole
N-benzyl-2-nitroimidazole-1-acetamide
22994-85-0
GB
1138529
Protozoacide



benzocaine
Benzoic acid, 4-amino-, ethyl ester
94-09-7


Formulation, fixed-dose
Pain, musculoskeletal







combinations



Benzoctamine

17243-39-9






Benzonatate

104-31-4






Benzoxonium 

19379-90-9






Chloride








benzoyl peroxide
Peroxide, dibenzoyl [CAS]
94-36-0


Formulation, other
Acne


Benzoylpas

13898-58-3






Benzphetamine

156-08-1






Benzpiperylon

53-89-4






Benzquinamide

63-12-7






Benzthiazide

91-33-8






Benztropine

132-17-2






benzydamine
1-Propanamine, N,N-dimethyl-3-[[1-
132-69-4


Stomatologic




(phenylmethyl)-1H-indazol-3-yl]oxy]-
642-72-8


reproductive,




[CAS]



inflammatory



Benzyl Benzoate

120-51-4






Benzylhydro-

1824-50-6






chlorothiazide








Benzylmorphine

14297-87-1






Bephenium

3818-50-6






Hydroxy-








naphthoate








bepotastine
1-Piperidinebutanoic acid, 4-((4-
190786-44-8
WO
9829409
Antiallergic, non-asthma
Allergy, general



chlorophenyl)-2-pyridinylmethoxy)-, (S)-, 
190786-43-7







monobenzenesulfonate [CAS]







bepridil
1-Pyrrolidineethanamine, β-[(2-
64706-54-3
EP
146155
Antianginal
Angina, general



methylpropoxy)methyl]-N-phenyl-N-
74764-40-2







(phenylmethyl)-[CAS]
74764-75-3






beraprost
1H-Cyclopenta[b]benzofuran-5-
88475-69-8
U.S.
4,474,802
Prostaglandin
Peripheral vascular 



butanoic acid, 2,3,3a,8b-tetrahydro-2-
88430-50-6



disease



hydroxy-1-(3-hydroxy-4-methyl-1-octen-








6-ynyl)-[CAS]







Berberine

2086-83-1






Bergapten

484-20-8






Bermoprofen

78499-27-1






Besipirdine

119257-34-0






betahistine
2-Pyndineethanamine, N-methyl-,
5579-84-0


Formulation, modified-
Maniere′s disease



dihydrochloride
5638-76-6


release, <=24 hr



betaine
Betaine-[CAS]
107-43-7


Metabolic and enzyme 
Homocystinuria







disorders



betamethasone
Pregna-1,4-diene-3,20-dione, 9-fluoro-
378-44-9


Formulation, dermal, 
Psoriasis



11,17,21-trihydroxy-16-methyl-,



topical




(11β,16β)-[CAS]







Betamipron

3440-28-6






Betasine

3734-24-5






betaxolol
2-Propanol, 1-[4-[2-
63659-18-7
U.S.
4,252,984
Antihypertensive, 
Hypertension, general



(cyclopropylmethoxy)ethyl]phenoxy]-3-
63659-19-8


adrenergic
glaucoma



[(1-methylethyl)amino]-[CAS]







Betazole

105-20-4






Bethanechol

590-63-6






Bethanidine

55-73-2






Betoxycaine

3818-62-0






b-Eucaine

500-34-5






bevantolol
2-Propanol, 1-[[2-(3,4-
42864-78-8
U.S.
3,857,891
Antihypertensive, 
Hypertension, general



dimethoxyphenyl)ethyl]amino]-3-(3-
59170-23-9


adrenergic




methylphenoxy)-[CAS]







Bevonium

5205-82-3






bexarotene
Benzoic acid, 4-(1-(5,6,7,8-tetrahydro-
153559-49-0
WO
9321146
Anticancer, other
Cancer, lymphoma, 



3,5,5,8,8-pentamethyl-2-




T-cell



naphthalenyl)ethenyl)-[CAS]







bezafibrate
Propanoic acid, 2-[4-[2-[(4-
41859-67-0
GB
1359264
Hypolipaemic/




chlorobenzoyl)amino]ethyl]phenoxy]-2-



Antiatherosclerosis




methyl-[CAS]







Bezitramide

15301-48-1






BG-9928

166374-48-7


Cardiostimulant
Heart failure


BIA-2-024
10,11-dihydro-10-hydroxyimino-5H-
199997-15-4
WO
9745416
Antiepileptic
Epilepsy, general



dibenz/b,f/azepine-5-carboxamide







BIA-2-093
(S)-(−)-10-acetoxy-10,11-dihydro-5H-
236395-14-5


Antiepileptic
Epilepsy, general



dibenzo/b,f/azepine-5-carboxamide-








[CAS]







BIA-3-202
1-(3,4-dihydroxy-5-nitrophenyl)-2-
274925-86-9
EP
1010688
Antiparkinsonian
Parkinson's disease



phenyl-ethanone







Bialamicol

493-75-4






biapenem
5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium,
120410-24-4
EP
289801
Beta-lactam antibic
Infection, beta-



6-[[2-carboxy-6-(1-hydroxyethyl)-4-




lactamase resistant



methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-








en-3-yl]thio]-6,7-dihydro-, hydroxide,








inner salt, [4R-[4Alpha,5β,6β(R*)]]-








[CAS]







Bibenzonium

15585-70-3






Bibrocathol

6915-57-7






bicalutamide
Propanamide, N-[4-cyano-3-
90357-06-5
EP
100172
Anticancer, hormonal
Cancer, prostate



(trifluoromethyl)phenyl]-3-[(4-








fluorophenyl)sulfonyl]-2-hydroxy-2-








methyl-, (+/−)-[CAS]







bicifadine
3-Azabicyclo[3.1.0]hexane, 1-(4-
66504-75-4
DE
2740562
Analgesic, other
Pain, general



methylphenyl)-, (+/−)-[CAS]
71195-57-8






bicyclic 


U.S.
6,294,585
Dermatological
Unspecified


monoter-








penediols








Bidisomide

116078-65-0






Betamiverine

479-81-2






Bietanautine

6888-11-5






Bietaserpine

53-1 8-9






bifemelane
1-Butanamine, N-methyl-4-[2-
62232-46-6
GB
1512880
Cognition enhancer
Attention deficit 



(phenylmethyl)phenoxy]-, hydrochloride
90293-01-9



disorder



[CAS]







Bifluranol

34633-34-6






bifonazole
1H-Imidazole, 1-([1,1-biphenyl]-4-
60628-96-8
U.S.
4,118,487
Antifungal
Infection, fungal, 



ylphenylmethyl)-[CAS]
60629-08-5



general




60629-09-6






bimatoprost
5-Heptenamide, 7-(3,5-dihydroxy-2-(3-
155206-00-1
U.S.
5,688,819
Prostaglandin
Glaucoma



hydroxy-5-phenyl-1-








pentenyl)cyclopentyl)-N-ethyl (1R-








(1Alpha(Z)2β(1E,3S,3Alpha,5Alpha))








[CAS]







bimoclomol
N-[2-hydroxy-3-(1-piperidinyl)propoxy]-
130493-04-8
U.S.
5,147,874
Symptomatic antidiabetic
Neuropathy, diabetic



3-pyridinecarboximidoyl chloride, (Z)-2-








butanedioate (1:1)







bimosiamose
(1,1-Biphenyl)-3-acetic acid, 3′,3′′′-(1,6-
187269-40-5
U.S.
5,444,050
Antiasthma
Asthma



hexanediyl)bis(6-Alpha-D-








mannopyranosyloxy)-, [CAS]







Binifibrate

69047-39-8






binodenoson
Adenosine, 2-
144348-08-3


Vasodilator, coronary
Diagnosis, coronary



((cyclohexylmethylene)hydrazino)-








[CAS]







Biomed-101


U.S.
6,423,744
Anticancer, other
Cancer, renal


Biotin

58-85-5






Biperiden

514-65-8






biricodar
2-Piperidinecarboxylic acid, 1-
174254-13-8


Radio/chemosensitizer
Cancer, breast



(oxo(3,4,5-trimethoxyphenyl)acetyl)-,4-
159997-94-1







(3-pyridinyl)-1-(3-(3-








pyridinyl)propyl)butyl ester, (S)-, 2-








hydroxy-1,2,3-propanetricarboxylate








(1:2) [CAS]







biriperone
1-Butanone, 1-(4-fluorophenyl)-4-
42021-34-1
DE
2333922
Neuroleptic




(3,4,6,7,12,12a-








hexahydropyrazino[1′,2′:1,6]pyrido[3,4-








b]indol-2(1H)-yl)-[CAS]







Bisacodyl

603-50-9






Bisantrene

78186-34-2






Bisbentiamine

2667-89-2






Bisdequalinium

52951-36-7






Bismuth 

12284-76-3






Aluminate








Bismuth 

53897-25-9






Butylthiolaurate








Bismuth Ethyl 

52951-37-8






Camphorate








Bismuth 

138-58-9






lodosubgallate








Bismuth 

53778-50-0






Sodium Iodide








Bismuth Sodium

5798-43-6






Triglycollamate








Bismuth 

5892-10-4






Subcarbonate








Bismuth 

22650-86-8






Subgallate








Bismuth 

1304-85-4






Subnitrate








Bismuth 

14882-18-9






Subsalicylate








Bismuth 

5175-83-7






Tribro-








mophenate








bisoprolol
2-Propanol, 1-[4-[[2-(1-
104344-23-2
GB
1532380
Antihypertensive, 
Heart failure



methylethoxy)ethoxy]methyl]phenoxy]-
66722-44-9


adrenergic




3-[(1-methylethyl)amino]-[CAS]







bisoprolol + 
2-Propanol, 1-[4-[[2-(1-



Formulation, 
Hypertension, 


HCTZ
methylethoxy)ethoxy)methyl]phenoxy]-



fixed dose
general



3-[(1-methylethyl)amino] mixt. with 6-



combinations




chloro-3,4-dihydro-2H-1,2,4-








benzothiadiazine-7-sulfonamide 1,1-








dioxide







bisoprolol + 
2-Propanol, 1-[4-[[2-(1-



Formulation, 
Hypertension, 


trichloro-
methylethoxy)ethoxyjmethyl]phenoxy]-



fixed-dose
general


methiazide
3-[(1-methylethyl)amino] mixt. with 6-



combinations




chloro-3-(dichloromethyl)-3,4-dihydro-








2H-1,2,4-benzothiadiazine-7-








sulfonamide 1,1-dioxide







Bisoxatin

14008-48-1






Bithionol

97-18-7






Bitolterol

30392-40-6






Bitoscanate

4044-65-9






BL-3875


WO
0218378
Anti-inflammatory
Unspecified


bleomycin
Bleomycin [CAS]
11056-06-7


Formulation, transdermal, 
Cancer, head and neck




9041-93-4


enhanced



blonanserin
Cycloocta[b]pyridine, 2-(4-ethyl-1-
132810-10-7
EP
385237
Neuroleptic
Schizophrenia



piperazinyl)-4-(4-fluorophenyl)-








5,6,7,8,9,10-hexahydro-[CAS]







BMS-184476


EP
639577
Anticancer, other
Cancer, breast


BMS-387032
cis-(+/−)-2-(Ethylthio)-5,7-dihydroxy-8-

WO
9742949
Anticancer, other
Cancer, general



(3-hydroxy-1-methyl-4-piperidinyl)-4H-1








benzopyran-4-one







BN-82451
4-[2-(aminomethyl)-1,3-thiazol-4-yl]-2,6-



Neuroprotective
Unspecified



di-tert-butylphenol, dihydrochloride







BNP-7787
Ethanesulfonic acid, 2,2′-dithiobis-,
16208-51-8


Radio/chemoprotective
Chemotherapy-



disodium salt




induced nausea 



[CAS]




and vomiting


BO-653
5-Benzofuranol, 4,6-bis(1,1-
157360-23-1
WO
9408930
Hypolipaemic/
Antherosclerosis



dimethylethyl)-2,3-dihydro-2,2-dipentyl-



Antiatherosclerosis




[CAS]







Bolandiol

19793-20-5






Bolasterone

1605-89-6






Boldenone

846-48-0






bopindolol
2-Propanol, 1-[(1,1-
62658-63-3
U.S.
4,340,541
Antihypertensive, 
Hypertension, general



dimethylethyl)amino]-3-[(2-methyl-1H-
82857-38-3


adrenergic




indol-4-yl)oxy]-, benzoate (ester), (+/−)-








[CAS]







Bornyl 

464-41-5






Chloride








Bornyl 

560-88-3






Salicylate








bortezomib
Boronic acid, [(1R)-3-methyl-1-[[(2S)-1-
179324-69-7
U.S.
6,271,199
Anticancer, other
Cancer, myeloma



oxo-3-phenyl-2-[(pyrazinyl-








carbonyl)amino]propyl]amino]butyl]-








[CAS]







bosentan
Benzenesulfonamide, 4-(1,1-
147536-97-8
EP
633259
Vasodilator, peripheral
Hypertension, 



dimethylethyl)-N-[6-(2-hydroxyethoxy)-




pulmonary



5-(2-methoxyphenoxy)[2,2-bipynmidin]








4-yl]-[CAS]







BP2.94
Phenol, 2-[[[(1R)-2-(1H-imidazol-4-yl)-1-
139191-80-3
WO
9117146
Respiratory
Rhinitis, general



methylethyl]imino]phenylmethyl]








[CAS]







BP4.897
N-[4-[4-(2-methoxyphenyl)-1-

EP
779284
Dependence treatment
Addiction, cocaine



piperazinyl]butyl]naphthalene-2-








carboxamide







b-Propiolactone

57-57-8






Bradycor

140661-97-8






Brain Natriuretic 

114471-18-0






Peptide








Brallobarbital

561-86-4






brasofensine
8-Azabicyclo(3.2.1)octane-2-
171655-91-7
WO
9528401
Antiparkinsonian
Parkinson′s disease



carboxaldehyde, 3-(3,4-dichlorophenyl)-








8-methyl-, O-methyloxime, (1R-








(1Alpha,2β(E),3Alpha,5Alpha))-[CAS]







Brequinar

96187-53-0






Bretylium

61-75-6






Brilliant Green

633-03-4






brimonidine
6-Quinoxalinamine, 5-bromo-N-(4,5-
59803-98-4
DE
2538620
Antiglaucoma
Glaucoma



dihydro-1H-imidazol-2-yl)-[CAS]







brinzolamide
2H-Thieno(3,2-e)-1,2-thiazine-6-
138890-62-7
U.S.
5,378,703
Antiglaucoma
Glaucoma



sulfonamide, 4-(ethylamino)-3,4-








dihydro-2-(3-methoxypropyl)-, 1,1-








dioxide, (R)-[CAS]







brivudin
Uridine, 5-(2-bromoethenyl)-2-deoxy,
69304-47-8


Antiviral, other
Infection, varicella 



(E)-[CAS]




zoster virus


Brodimoprim

56518-41-3






Bromazepam

1812-30-2






bromfenac
Benzeneacetic acid, 2-amino-3-(4-
91714-93-1


Formulation, mucosal, 
Inflammation, ocular



bromobenzoyl)-[CAS]
91714-94-2


topical



Bromhexine

3572-43-8






Bromindione

1146-98-1






Bromisovalum

496-67-3






Bromocriptine

25614-03-3






Bromodiphen-

118-23-0






hydramine








Bromoform

75-25-2






Bromopride

4093-35-0






Bromosalicyl-

3679-64-9






chloranilide








bromperidol
1-Butanone, 4-[4-(4-bromophenyl)-4-
10457-90-6
U.S.
3,438,991
Neuroleptic
Psychosis, general



hydroxy-1-piperidinyl]-1-(4-








fluorophenyl)-[CAS]







Bromphen-

86-22-6






iramine








Broparoestrol

479-68-5






Bropirimine

56741-95-8






brostallicin
4-(2-Bromoacrylamido)-N′′′-(2-



Anticancer, other
Cancer, general



guanidinoethyl)-1,1′,1′′,1′′′-tetramethyl-








N,4′:N′,4′′:N′′,4′′′-quater-[pyrrole-2-








carboxamide] [CAS]







brotizolam
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-
57801-81-7 
U.S.
4,094,984
Hypnotic/Sedative




a][1,4]diazepine, 2-bromo-4-(2-








chlorophenyl)-9-methyl-[CAS]







Brovincamine

57475-17-9






Broxuridine

59-14-3






Broxyquinoline

521-74-4






Brucine

357-57-3






b-Sitosterol

83-46-5






Bucetin

1083-57-4






Bucillamine

65002-17-7






Bucindolol

71119-11-4






bucladesine
Adenosine, N-(1-oxobutyl)-, cyclic 3′,5′-
362-74-3
JP
51113896
Cardiostimulant
Wound healing



(hydrogen phosphate) 2-butanoate








[CAS]







Buclizine

82-95-1






Buclosamide

575-74-6






Bucolome

841-73-6






bucricaine
9-Acridinamine, N-butyl-1,2,3,4-
82636-28-0


Anaesthetic, local




tetrahydro-, monohydrochloride [CAS]







Bucumolol

58409-59-9






budesonide
Pregna-1,4-diene-3,20-dione, 16,17-
51333-22-3
GB
1429922
Antiasthma
Asthma



[butylidenebis(oxy)]-11,21-dihydroxy-,








(11β,16Alpha)-[CAS]







budesonide + 
Pregna-1,4-diene-3,20-dione, 16,17-



Formulation, fixed-dose
Asthma


formoterol
[butylidenebis(oxy)]-11,21-dihydroxy-,



combinations




(11β,1bAlpha) + formamide, N-[2-








hydroxy-5-[1-hydroxy-2-[[2-(4-








methoxyphenol)-1-








methylethyl]amino]ethyl]phenyl]-








(R*,R*)-(±)







budipine
Piperidine, 1-(1,1-dimethylethyl)-4,4-
57982-78-2
DE
2825322
Antiparkinsonian
Parkinson′s disease



diphenyl-[CAS]
63661-61-0






Budralazine

36798-79-5






Bufeniode

22103-14-6






Bufetolol

53684-49-4






bufexamac
p-butoxyacetohydroxamic acid
2438-72-4
U.S.
3,479,396
Anti-inflammatory



buflomedil
1-Butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-
35543-24-9
GB
1325192
Vasodilator, peripheral




trimethoxyphenyl)-[CAS]
55837-25-7






Buformin

692-13-7






Bufuralol

S4340-62-4






Bumadizon

3583-64-0






bumetanide
Benzoic acid, 3-(aminosulfonyl)-5-
28395-03-1
U.S.
3,806,534
Antihypertensive, 
Hypertension, general



(butylamino)-4-phenoxy-[CAS]



diuretic



bunaftine
1-Naphthalenecarboxamide, N-butyl-N-
32421-46-8
DE
2009894
Antiarrhythmic




[2-(diethylamino)ethyl]-[CAS]







Bunamiodyl 

1923-76-8






Sodium








bunazosin
1H-1,4-Diazepine, 1-(4-amino-6,7-
52712-76-2
GB
1398455 
Antihypertens




dimethoxy-2-quinazolinyl)hexahydro-4-
80755-51-7







(1-oxobutyl)-[CAS]







bunitrolol
Benzonitrile, 2-[3-[(1,1-
34915-68-9
U.S.
3,940,489
Antihypertensive, 




dimethylethyl)amino]-2-



adrenergic




hydroxypropoxy]-[CAS]







bupivacaine
2-Piperidinecarboxamide, 1-butyl-N-
38396-39-3


Formulation, modified-
Anaesthesia



(2,6-dimethylphenyl)-[CAS]
2180-92-9


release >24 hr



Bupranolol

14556-46-8






buprenorphine
6,14-Ethenomorphinan-7-methanol, 17-
52485-79-7
U.S.
3,433,791
Analgesic, other




(cyclopropylmethyl)-Alpha-(1,1-
53152-21-9







dimethylethyl)-4,5-epoxy-18,19-dihydro-








3-hydroxy-6-methoxy-Alpha-methyl-,








[5Alpha,7Alpha(S)]-[CAS]







bupropion
1-Propanone, 1-(3-chlorophenyl)-2-
31677-93-7
U.S.
4,425,363
Antidepressant
Depression, general



[(1,1-dimethylethyl)amino]-, (+/−)-
34911-55-2







[CAS]







Buramate

4663-83-6






buserelin
Luteinizing hormone-releasing factor
57982-77-1
GB
1523623
Releasing hormones
Cancer, prostate



(pig), 6-[O-(1,1-dimethylethyl)-D-serine] 
68630-75-1







9-(N-ethyl-L-prolinamide)-10-








deglycinamide-[CAS]







buspirone
8-Azaspiro[4.5]decane-7,9-dione, 8-[4-
36505-84-7
EP
276536
Anxiolytic
Anxiety, general



[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-








[CAS]







busulfan
1,4-Butanediol, dimethanesulfonate
55-98-1


Formulation, optimized
Cancer, general



[CAS]



microparticles



busulfan
1,4-Butanediol, dimethanesulfonate-
55-98-1


Formulation, parenteral, 
Cancer, leukaemia, 



[CAS]



other
acute myelogenous


Butabarbital

143-81-7






Butacaine

149-16-6






Butacetin

2109-73-1






Butalamine

22131-35-7






Butalbital

77-26-9






Butallylonal

1142-70-7






butamben
4-Aminobenzoic acid butyl ester [CAS]
94-25-7


Formulation, modified-
Pain, cancer







release, other



butamirate
Benzeneacetic acid, Alpha-ethyl-, 2-[2-
18109-80-3


Antitussive
Cough



(diethylamino)ethoxy]ethylester, 2-
18109-81-4







hydroxy-1,2,3-propanetricarboxylate








(1:1) [CAS]







Butanilicaine

3785-21-5






Butaperazine

653-03-2






Butaverine

55837-14-4






Butazolamide

16790-49-1






Butedronic 

51395-42-7






Acid








butenafine
1-Naphthalenemethanamine, N-((4-
101827-46-7
EP
164697
Antifungal
Infection, 



(1,1-dimethylethyl)phenyl)methyl)-N-
101828-21-1



dermatological



methyl-[CAS]







Butethal

77-28-1






Butethamate

14007-64-8






Butethamine

2090-89-3






Buthalital

510-90-7






Buthiazide

2043-38-1






Butibufen

55837-18-8






Butidrine

1506-12-3 






butobendine
benzoic acid, 3,4,5-trimethoxy-, 1,2-
55769-64-7
U.S.
4,021,473
Antiarrhythmic
Arrhythmia, general



ethanediylbis[(methylimino)(2-ethyl-2,1-
55769-65-8







ethanediyl)] ester, [S-(R*,R*)]-[CAS]







butoconazole
1H-Imidazole, 1-[4-(4-chlorophenyl)-2-
64872-76-0
GB
1567431
Antifungal
Infection, Candida, 



[(2,6-dichlorophenyl)thio]butyl]-, (+/−)-
64872-77-1



general



[CAS]







Butoctamide

32838-26-9






Butofilolol

64552-17-6






butorphanol
Morphinan-3,14-diol, 17-
42408-82-2
GB
1412129
Analgesic, other




(cyclobutylmethyl)-, [S-(R*,R*)]-2,3-
58786-99-5







dihydroxybutanedioate (1:1) (salt)








[CAS]







Butoxycaine

3772-43-8






Butriptyline

35941-65-2






Butropium

29025-14-7






Buzepide

3691-21-2






BVT-5182


WO
0208178
Anorectic/Antiobesity
Obesity


BXT-51072
2H-1,2-Benzoselenazine, 3,4-dihydro-
173026-17-0


GI inflammatory/bowel 
Colitis, ulcerative



4,4-dimethyl-[CAS]



disorders



C-1311
6H-Imidazo[4,5,1-de]acridin-6-one, 5-



Anticancer, other
Cancer, general



[[2-(diethylamino)ethyl]amino]-8-








hydroxy-, 2HCl, 2H2O







cabergoline
Ergoline-8-carboxamide, N-[3-
81409-90-7
GB
2103603
Antiprolactin
Galactorrhoea



(dimethylamino)propyl]-N-
85329-89-1







[(ethylamino)carbonyl]-6-(2-propenyl)-,








(8β)-[CAS]







Cabergoline

81409-90-7






Cacodylic 

75-60-5






Acid








Cactinomycin

8052-16-2






cadexomer 
Cadexomer iodine [CAS]
94820-09-4


Anti-infective, other
Ulcer, venostasis


iodine








Cadmium 

19010-79-8






Salicylate








Cadralazine

64241-34-5






Cafaminol

30924-31-3






caffeine
1,2,3,-Propanetncarboxylic acid, 2-
69-22-7


Respiratory
Apnoea



hydroxy- mixt. with 3,7-dihydro-1,3,7-
58-08-2







trimethyl-1H-purine-2,6-dione [CAS]







Calcifediol

19356-17-3






Calcipotriene

112965-21-6






calcipotriol
9,10-Secochola-5,7,10(19),22-tetraene-








1,3,24-triol, 24-cyclopropyl-,
112965-21-6
WO
8700834
Antipsoriasis
Psoriasis



(1Alpha,3β,5Z,7E,22E)-[CAS]







calcipotriol + 
9,10-Secochola-5,7,10(19),22-tetraene-



Formulation, fixed-dose
Psoriasis


beclometasone
1,3,24-triol, 24-cyclopropyl-,



combinations




(1Alpha,3β,5Z,7E,22E) + Pregna-1,4-








diene-3,20-dione, 9-chloro-11β,17,21-








trihydroxy-16β-methyl, 17,21-








dipropionate







calcitriol
9,10-Secocholesta-5,7,10(19)-triene-
32222-06-3


Antipsoriasis
Psoriasis



1,3,25-triol, (1Alpha,3β,5Z,7E)-[CAS]







Calcium 3-

5743-29-3






Aurothio-2-








propanol-1-








sulfonate








Calcium 

69-46-5






Acetyl-








salicylate








Calcium 

33659-28-8






Bromolac-








tobionate








Calcium 

471-34-1






Carbonate








Calcium 

299-28-5






Gluconate








Calcium 

27214-00-2






Glycero-








phosphate








calcium 
Calcium D-(+)-4-(2,4-dihydroxy-3,3-
17097-76-6
EP
117260
Neurological
Attention deficit 


hopantothenate
dimethylbutyramido)butyrate




disorder



(hemihydrate) [CAS]







Calcium 

1319-91-1






lodobehenate








Calcium 

1301-16-2






lodostearate








Calcium 

814-80-2






Lactate








Calcium 

591-64-0






Levulinate








Calciuhi 

21085-60-9






Mesoxalate








Calcium N-

16649-79-9






Carbamoyl-








aspartate








calcium 
Polycarbophil, calcium salt-[CAS]
126040-58-2


GI inflammatory/bowel 
Irritable bowel 


polycarbophil

9003-97-8


disorders
syndrome


Calcium 

4075-81-4






Propionate








Calcium 

140-99-8






Succinate








caldaret
5-methyl-2-(1-piperazinyl)-
133804-44-1


Cardiostimulant
Heart failure



benzenesulfonic acid monohydrate







Calusterone

17021-26-0






Camazepam

36104-80-0






camostat
Benzeneacetic acid, 4-[[4-
59721-28-7
U.S.
4,021,472
GI inflammatory/bowel 
Pancreatitis



[(aminoiminomethyl)amino]benzoyl]oxy]-,
59721-29-8


disorders




2-(dimethylamino)-2-oxoethyl ester,
71079-09-9







monomethanesulfonate [CAS]







Camphor

76-22-2






Camphotamide

4876-45-3






camptothecin
4-Ethyl-4-hydroxy-1H-pyrano-



Formulation, optimized
Cancer, general



[I3′4′:6,7]indolizinol[1,2-b;]quinoline-



microemulsion




3,14(4H,12H)-dione








microemulsion







Candesartan

139481-59-7






candesartan 
1H-Benzimidazole-7-carboxylic acid, 2-
145040-37-5
EP
520423
Antihypertensive, renin 
Hypertension, general


cilexetil
ethoxy-1-[[2′-(1H-tetrazol-5-yl)[1,1′-



system




biphenyl]-4-yl]methyl]-, 1-








[[(cyclohexyloxy)carbonyl]oxy]ethyl








ester, (+/−)-[CAS]







Candoxatril

123122-55-4






canertinib
N-[4-(3-(Chloro-4-fluoro-phenylamino)-
289499-45-2


Anticancer, other
Cancer, lung, 



7-(3-morpholin-4-yl-propoxy)-quinazolin




non-small cell



6-yl]-acrylamide







Canrenone

976-71-6






Cantharidin

56-25-7






cantuzumab 
Maytansine, N2-deacetyl-N2-(3-
139504-50-0


Immunotoxin
Cancer, colorectal


mertansine
mercapto-1-oxopropyl)-, conjugated








humanized C242 monoclonal antibody







capecitabine
Cytidine, 5-deoxy-5-fluoro-N-
154361-50-9
EP
602454
Anticancer, 
Cancer, breast



[(pentyloxy)carbonyl]-[CAS]



antimetabolite



Capobenic 

21434-91-3






Acid








capravirine
1H-imidazole-2-methanol, 5-(3,5-
178979-85-6


Antiviral, anti-HIV
Infection, HIV/AIDS



dichlorophenyl)thio-4-(1-methylethyl)-1-








(4-pyridinyl)methyl carbamate (ester)








[CAS]







Capromab

151763-64-3






capsaicin 
N-[(4-hydroxy-3-methoxyphenyl)methyl]
404-86-4


Formulation, dermal, 
Pain, post-herpetic


cream
8-methyl-, (E)-[CAS]



topical



Captodiamine

486-17-9






captopril
L-Proline, 1-(3-mercapto-2-methyl-1-
62571-86-2
U.S.
4,105,776
Antihypertensive, renin 
Hypertension, general



oxopropyl)-, (S)-[CAS]



system



captopril + 
L-Proline, 1-(3-mercapto-2-methyl-1-
110075-07-5
U.S.
4,217,347
Antihypertensive, renin 



HCTZ
oxopropyl)-, (S)-, mixt. with 6-chloro-



system




3,4-dihydro-2H-1,2,4-benzothiadiazine-








7-sulfonamide 1,1-dioxide [CAS]







Capuride

5579-13-5






carabersat
Benzamide, N-(6-acetyl-3,4-dihydro-3-
184653-84-7
WO
9811890
Antiepileptic
Epilepsy, general



hydroxy-2,2-dimethyl-2H-1-benzopyran-








4-yl)-4-fluoro, (3R-trans)-[CAS]







Caramiphen

77-22-5






carazolol
2-Propanol, 1-(9H-carbazol-4-yloxy)-3-
57775-29-8
DE
2240599
Antihypertensive, 




[(1-methylethyl)amino]-[CAS]



adrenergic



Carbachol

51-83-2






carbamazepine
5H-Dibenz[b,f]azepine-5-carboxamide
298-46-4


Formulation, modified-
Epilepsy, general



[CAS]



release, other



Carbamide 

124-43-6






Peroxide








Carbarsone

121-59-5






Carbaryl

63-25-2






Carbazochrome

13051-01-9








51460-26-5






carbendazim
Methyl-2-benzimidazolecarbamate



Anticancer, other
Cancer, general


Carbenicillin

4697-36-3






Carbenoxolone

5697-56-3






Carbetapentane

77-23-6






Carbicarb
Carbonic acid disodium salt, mixt. with
72227-05-5


Alimentary/Metabolic, 
Acidosis



monosodium salt-[CAS]



other



Carbidopa

28860-95-9






carbidopa + 
S-Alpha Hydrazino-3,4-dihydroxy-Alpha



Formulation, fixed-dose
Parkinson's disease


levodopa-1
methyl benzene propanoic acid



combinations




monohydrate + 3-hydroxy-L-tyrosine







Carbimazole

22232-54-8






Carbinoxamine

486-16-8






Carbocloral

541-79-7






carbocysteine

151756-26-2
EP
546272
Cystic fibrosis treatment
Cystic fibrosis




638-23-3






Carbon 

56-23-5






Tetrachloride








carboplatin
Platinum, diammine[1,1-
41575-94-4


Anticancer, alkylating
Cancer, ovarian



cyclobutanedicarboxylato(2-)]-, (SP-4-








2)-[CAS]







Carboprost

35700-23-3






carboprost 
Prosta-5,13-dien-1-oic acid, 9,11,15-
58551-69-2
U.S.
3,728,382
Prostaglandin
Abortion


trometamol
trihydroxy-15-methyl-,
74849-93-7







(5Z,9.alpha.,11Alpha,13E,15S)-,








compd. with 2-amino-2-








(hydroxymethyl)-1,3-propanediol(1:1)








[CAS]







Carboquone
2,5-Cyclohexadiene-1,4-dione, 2-[2-
24279-91-2
DE
1905224
Anticancer, antibiotic




[(aminocarbonyl)oxy]-1-methoxyethyl]-








3,6-bis(1-aziridinyl)-5-methyl-[CAS]







Carbromal

77-65-6






Carbubarb

960-05-4






Carbutamide

339-43-5






Carbuterol

34866-47-2






Carfimate

3567-38-2






carglumic acid
N-Carbamoyl-L-glutamic acid
1188-38-1


Metabolic and enzyme 
Hyperammonaemia


Cargutocin

33605-67-3


disorders



Carindacillin

35531-88-5






cariporide
Benzamide, N-(aminoiminomethyl)-4-
159138-80-4
EP
589336
Antianginal
Angina, general



(1-methylethyl)-3-(methylsulfonyl)-
159138-81-5







[CAS]







Cariporide

159138-80-4






Carisoprodol

78-44-4






carmofur
1(2H)-Pyrimidinecarboxamide, 5-fluoro-
61422-45-5
U.S.
4,071,519
Anticancer, 




N-hexyl-3,4-dihydro-2,4-dioxo-[CAS]



antimetabolite



Carmoxirole

98323-83-2






carmustine
Urea, N,N-bis(2-chloroethyl)-N-nitroso-
154-93-8


Formulation, implant
Cancer, brain



[CAS]







Carnitine

461-06-3






Caroverine

23465-76-1






Caroxazone

18464-39-6 






Carphenazine

2622-30-2






Carpipramine

5942-95-0






carprofen
9H-Carbazole-2-acetic acid, 6-chloro-
53716-49-7 
U.S.
3,896,145
Anti-inflammatory




Alpha-methyl-, (+/−)-[CAS]







Carsalam

2037-95-8






carteolol
2(1H)-Quinolinone, 5-[3-[(1,1-
51781-06-7
U.S.
3,910,924
Antihypertensive, 
Glaucoma



dimethylethyl)amino]-2-
51781-21-6


adrenergic




hydroxypropoxy]-3,4-dihydro-,








monohydrochloride [CAS]







Carticaine

23964-58-1






Carubicin

50935-04-1






Carumonam

87638-04-8






Carvacrol

499-75-2






carvedilol
2-Propanol, 1-(9H-carbazol-4-yloxy)-3-
72956-09-3
EP
4920
Antihypertensive, 
Hypertension, 



[[2-(2-methoxyphenoxy)ethyl]amino]-



adrenergic
general



[CAS]







Carvone

99-49-0






Cascarillin

10118-56-6






caspofungin
Pneumocandin B0, 1-((4R,5S)-5-((2-
162808-62-0
WO
9421677
Antifungal
Infection,



aminoethyl)amino)-N2-(10,12-dimethyl-
179463-17-3



Aspergillus



1-oxotetradecyl)-4-hydroxy-L-ornithine)








5-(threo-3-hydroxy-L-ornithine)-,








diacetate (salt) [CAS]







Catechin

154-23-4






cathepsin K 
N-(1-benzothien-2-ylcarbonyl)-N-[2-(2-

WO
9613523
Osteoporosis treatment
Osteoporosis


inhibitors
fluorophenyl)-4-oxo-1,2,3,4-








tetrahydropyrimidin-5-yl]-L-leucinamide







cathepsin S 
N-(1-benzothien-2-ylcarbonyl)-N-[2-(2-



Antiasthma
Asthma


inhibitors
fluorophenyl)-4-oxo-1,2,3,4-








tetrahydropyrimidin-5-yl]-L-leucinamide







CC-401


U.S.
6,342,595
Immunosuppressant
Arthritis, rheumatoid


CCI-779
Rapamycin 42-(3-hydroxy-2-
162635-04-3


Anticancer, antibiotic
Cancer, renal



(hydroxymethyl)-2-methylpropanoate)








[CAS]







CCR5 


WO
9732019
Antiviral, anti-HIV
Infection, HIV/AIDS


antagonists








CDC-394


U.S.
634,061
Anticancer, other
Cancer, myeloma


CDC-801


U.S.
5,605,914
GI inflammatory/
Crohn's disease







bowel disorders



CEE-03-310
1H-3-Benzazepin-7-ol, 5-(2,3-dihydro-7
128022-68-4
EP
347672
Dependence treatment
Addiction, alcohol



benzofuranyl)- 2,3,4,5,-tetrahydro-3-








methyl-8-nitro, (5S)-[CAS]







cefaclor
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
53994-73-3
GB
1461323
Cephalosporin, oral
Infection, 



carboxylic acid, 7-
70356-03-5



Haemophilus



[(aminophenylacetyl)amino]-3-chloro-8-




influenzae



oxo-, [6R-[6Alpha,7β(R*)]]-[CAS]




prophylaxis


cefadroxil
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
50370-12-2
GB
1240687
Cephalosporin, oral
Infection, general



carboxylic acid, 7-[[amino(4-
66592-87-8







hydroxyphenyl)acetyl]amino]-3-methyl-








8-oxo-, [6R-[6Alpha,7β(R*)]]-[CAS]







cefalexin
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
8105879-42-3
U.S.
4,775,751
Cephalosporin, oral
Infection, respiratory 



carboxylic acid, 7-
15686-71-2



tract, upper



[(aminophenylacetyl)amino]-3-methyl-








oxo-, [CAS]







cefalexin 
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
27726-31-4


Cephalosporin, oral
Infection, general


pivoxil
carboxylic acid, 7-








[(aminophenylacetyl)amino]-3-methyl-8








oxo-, (2,2-dimethyl-1-








oxopropoxy)methyl ester,








monohydrochloride, [6R-








[6Alpha,7β(R*)]]-[CAS]







cefamandole
7-D-mandeiamido-3[[(1-methyl-1H-
34444-01-4
U.S.
3,641,021
Cephalosporin, 
Infection, general



tetrazol-5-yl)thio]methyl]-3-cephem-4-



injectable




carboxylic acid







cefatrizine
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
51627-14-6
GB
1460914
Cephalosporin, oral
Infection, general



carboxylic acid, 7-[[amino(4-








hydroxyphenyl)acetyl]amino]-8-oxo-3-








[(1H-1,2,3-triazol-4-ylthio)methyl]-, [6R-








[6Alpha,7β(R*)]]-[CAS]







Cefazedone

56187-47-4






Cefazolin

25953-19-9






Cefbuper-

76610-84-9






azone








cefcapene 
7β-[(Z)-2-(2-amino-4-thiazolyl)-2-
105889-45-0
GB
2173194
Cephalosporin, oral
Infection, respiratory 


pivoxil
pentenoylamino]-3-
105889-46-1



tract, general



carbamoyloxymethyl-3-cephem-4-








carboxylic acid, pivaloyloxymethyl ester








HCl-[CAS]







Cefclidin

105239-91-6






cefdinir
5-Thia-1-azabicyclo(4.2.0]oct-2-ene-2-
91832-40-5
EP
105459
Cephalosporin, oral
Infection, 



carboxylic acid, 7-[[(2-amino-4-




dermatological



thiazolyl)(hydroxyimino)acetyl]amino]-3-








ethenyl-8-oxo-, [6R-[6Alpha,7β(Z)]]-








[CAS]







cefditoren 
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
104145-95-1
JP
61178991
Cephalosporin, oral
Infection, general


pivoxil
carboxylic acid, 7-[[(2-amino-4-
104146-53-4







thiazolyl)(methoxyimino)acetyl]amino]-
117467-28-4







3-[2-(4-methyl-5-thiazolyl)ethenyl]-8-








oxo-, (2,2-dimethyl-1-








oxopropoxy)methyl ester, [6R-








[3(Z),6Alpha,7β(Z)]]-[CAS]







cefepime
Pyrrolidinium, 1-[[7-[[(2-amino-4-
107648-80-6
EP
531981
Cephalosporin, 
Infection, 



thiazolyl)(methoxyimino)acetyl]amino]-
123171-59-5


injectable
respiratory tract, 



2-carboxy-8-oxo-5-thia-1-
88040-23-7



lower



azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-








methyl-, hydroxide, inner salt, [6R-








[6Alpha,7β(Z)]]-[CAS]







Cefetamet

65052-63-3






cefetamet 
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
111696-23-2
GB
1581854
Cephalosporin, oral
Infection, general


pivoxil
carboxylic acid, 7-[[(2-amino-4-








thiazolyl)(methoxyimino)acetyl]amino]-








3-methyl-8-oxo-, (2,2-dimethyl-1-








oxopropoxy)methyl ester,








monohydrochloride, [6R-








[6Alpha,7β(Z)]]-[CAS]







cefixime
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
79350-37-1
EP
30630
Cephalosporin, oral
Infection, general



carboxylic acid, 7-[[(2-amino-4-








thiazolyl)[(carboxymethoxy)imino]acetyl








]amino]-3-ethenyl-8-oxo-, [6R-








[6Alpha,7β(Z)]]-[CAS]







cefmenoxime
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
65085-01-0
GB
1536281
Cephalosporin, 
Infection, ocular



carboxylic acid, 7-[[(2-amino-4-
75738-58-8


injectable




thiazolyl)(methoxyimino)acetyl]amino]-








3-[[(1-methyl-1H-tetrazol-5-








yl)thio]methyl]-8-oxo-, [6R-








[6Alpha,7β(Z)]]-[CAS]







cefmetazole
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-








carboxylic acid, 7-








[[[(cyanomethyl)thio]acetyl]amino]-7-
56796-20-4
GB
1449420
Cephalosporin,
Infection, general



methoxy-3-[[(1-methyl-1H-tetrazol-5-
56796-39-5


injectable




yl)thso]methyl]-8-oxo-, (6R-cis)-[CAS]







cefminox
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
84305-41-9
EP
24879
Cephalosporin, 
Infection, urinary 



carboxylic acid, 7-[[[(2-amino-2-



injectable
tract



carboxyethyl)thio]acetyl]amino]-7-








methoxy-3-[[(1-methyl-1H-tetrazol-5-








yl)thio]methyl]-8-oxo-, [6R-








[6Alpha,7Alpha,7(S*)]]-[CAS]







cefodizime
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
69739-16-8
U.S.
4,590,267
Cephalosporin, 
Infection, respiratory 



carboxylic acid, 7-[[(2-amino-4-
86329-79-5


injectable
tract, lower



thiazolyl)(methoxyimino)acetyl]amino]-








3-[[[5-(carboxymethyl)-4-methyl-2-








thiazolyl]thio]methyl]-8-oxo-, [6R-








[6Alpha,7β(Z)]]-[CAS]







cefonicid
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
61270-78-8
GB
1547473
Cephalosporin, 
Infection, general



carboxylic acid, 7-
61270-58-4


injectable




[(hydroxyphenylacetyl)amino]-8-oxo-3-








[[[1-(sulfomethyl)-1H-tetrazol-5-








yl]thio]methyl]-, disodium salt, [6R-








[6Alpha,7B(R)]]-[CAS]







cefoperazone
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
62893-19-0
GB
1508071
Cephalosporin, 
Infection, general



carboxylic acid, 7-[[[[(4-ethyl-2,3-dioxo-



injectable




1-piperazinyl)carbonyl]amino](4-








hydroxyphenyl)acetyl]amino]-3-[[(1-








methyl-1H-tetrazol-5-yl)thio]methyl]-8-








oxo-, [6R-[6Alpha,7β(R*)]]]-[CAS]







cefoperazone + 

92739-15-6
U.S.
4,234,579
Antibiotic, other
Infection, general


sulbactam








Ceforanide

60925-61-3






cefoselis
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
122841-12-7
EP
307804
Cephalosporin, 
Infection, general



carboxylic acid, 7-[[(2-amino-4-
122841-10-5


injectable




thiazolyl)(methoxyimino)acetyl]amino]-








3-[[2,3-dihydro-2-(2-hydroxyethyl)-3-








imino-1H-pyrazol-1-yl]methyl]-8-oxo-,








[6R-[6Alpha,7β(Z)]]







cefotaxime
(6R,7R)-7-[[(2-amino-4-








thiazolyl)(methoxyimino)acetyl]ami-
64485-93-4
GB
1580621
Cephalosporin, 
Infection, general



no]cephalsporanic acidsodium salt
63527-52-6


injectable



Cefotetan

69712-56-7






cefotiam
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
61622-34-2
U.S.
4,080,498
Cephalosporin, 
Infection, general



carboxylic acid, 7-[[(2-amino-4-
66309-69-1


injectable




thiazolyl)acetyl]amino]-3-[[[1-[2-








(dimethylamino)ethyl]-1H-tetrazol-5-








yl]thio]methyl]-8-oxo-, (6R-trans)-








[CAS]







cefotiam 
1-(cyclohexyloxycarbonyloxy)ethyl 7β-
95789-30-3
EP
128029
Cephalosporin, oral
Infection, respiratory 


hexetil 
[2-(2-aminothiazol-4-yl)acetamido]-3-




tract, lower



[[[1-(2-dimethylaminoethyl)-1H-tetrazol-








5-yl]thio]methyl]ceph-3-em-4-








carboxylate 2HCl [CAS]







cefoxitin
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-
33564-30-6
GB
1348984
Cephalosporin, oral
Infection, general



carboxylic acid, 3-
35607-66-0







(((aminocarbonyl)oxy)methyl)-7-








methoxy-8-oxo-7-((2-








thienylacetyl)amino)-, monosodium








salt, (6R-cis)-[CAS]







cefozopran
Imidazo[1,2-b]pyridazinium, 1-[[7-[[(5-
113359-04-9
EP
203271
Cephalosporin, 
Infection, general



amino-1,2,4-thiadiazol-3-



injectable




yl)(methoxyimino)acetyl]amino]-2-








carboxy-8-oxo-5-thia-1-








azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,








hydroxide, inner salt, [6R-








[6Alpha,7β(Z)]]-[CAS]







cefpimizole
Pyridinium, 1-[[2-carboxy-7-[[[[(5-








carboxy-1H-imidazol-4-








yl)carbonyl]amino]phenylacetyl]amino]-
84880-03-5
EP
60028
Cephalosporin, 
Infection, respiratory 



8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-
85287-61-2


injectable
tract, general



en-3-yl]methyl]-4-(2-sulfoethyl)-,








hydroxide, inner salt, [6R-








[6Alpha,7β4R*)]]-[CAS]







cefpiramide
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
70797-11-4
U.S.
4,156,724
Cephalosporin, 
Infection, general



carboxylic acid, 7-[[[[(4-hydroxy-6-



injectable




methyl-3-pyridinyl)carbonyl]amino](4-








hydroxyphenyl)acetyl]amino]-3-[[(1-








methyl-1H-tetrazol-5-yl)thio]methyl]-8-








oxo-, [6R-[6Alpha,7β(R*)]]-[CAS]







cefpirome
5H-1-Pyrindinium, 1-[[7-[[(2-amino-4-
84957-29-9
EP
64740
Cephalosporin, 
Infection, respiratory 



thiazolyl)(methoxyimino)acetyl]amino]-
98753-19-6


injectable
tract, lower



2-carboxy-8-oxo-5-thia-1-








azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-








6,7-dihydro-,hydroxide, inner salt, [6R-








[6Alpha,711(Z)]]-[CAS]







Cefpodoxime 

87239-81-4






Proxetil








cefprozil
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
92665-29-7
GB
2173798
Cephalosporin, oral
Infection, 



carboxylic acid, 7-[[amino(4-
121123-17-9



dermatological



hydroxyphenyl)acetyl]amino]-8-oxo-3-








(1-propenyl)-, [6R-[6Alpha,7β(R*)]]-








[CAS]







cefroxadine
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
51762-05-1
GB
143511
Cephalosporin, oral
Infection, general



carboxytic acid, 7-[(amino-1,4-








cyciohexadien-1-ylacetyl)amino]-3-








methoxy-8-oxo-, [6R-[6Alpha,7β(R*)]]-








[CAS]







cefsulodin
Pyridinium, 4-(aminocarbonyl)-1-([2-
52152-93-9
GB
138765
Cephalosporin, 
Infection, 



carboxy-8-oxo-7-
62587-73-9


injectable
pseudomonal



[(phenylsulfoacetyl)amino]-5-thia-1-








azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,








hydroxide, inner salt, [6R-








[6Alpha,7β(R*)]]-[CAS]







ceftazidime
Pyridinium, 1-[[7-[[(2-amino-4-
72558-82-8
GB
202539
Cephalosporin, 
Infection, respiratory 



thiazolyl)[(1-carboxy-1-



injectable
tract, upper



methylethoxy)imino]acetyl]amino]-2-








carboxy-8-oxo-5-thia-1-








azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,








hydroxide, inner salt, [6R-








[6Alpha,7β(Z)]]-[CAS]







Cefteram

82547-58-8






Ceftezole

26973-24-0






ceftibuten
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
97519-39-6
EP
136721
Cephalosporin, oral
Infection, respiratory 



carboxylic acid, 7-[[2-(2-amino-4-




tract, lower



thiazolyl)-4-carboxy-1-oxo-2-








butenyl]amino]-8-oxo-, [6R-








[6Alpha,7β(Z)]]-[CAS]







ceftizoxime
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
68401-81-0
GB
1600735
Cephalosporin, 
Infection, general



carboxylic acid, 7-[[(2-amino-4-
68401-82-1


injectable




thiazolyl)(methoxyimino)acetyl]amino]-








8-oxo-, [6R-[6Alpha,7β(Z)]]-[CAS]







ceftizoxime 
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
113812-94-5
JP
62209112
Cephalosporin, oral
Infection, general


alapivoxil
carboxylic acid, 7-[[[2-[(2-amino-1-
135767-36-1







oxopropyl)amino]-4-








thiazolyl](methoxyimino)acetyl]amino]-8








oxo-, (2,2-dimethyl-1-








oxopropoxy)methyl ester,








monohydrochloride, [6R-








[6Alpha,7β(Z(S*))]]-[CAS]







ceftriaxone
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
73384-59-5
GB
2022090
Cephalosporin, 
Infection, respiratory 



carboxylic acid, 7-[[(2-amino-4-
74578-69-1


injectable
tract,lower



thiazolyl)(methoxyimino)acetyl]amino]-








8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-








5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-,








[6R-[6Alpha,7β(Z)]]-[CAS]







cefuroxime 
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
15686-71-2
GB
1571683
Cephalosporin, oral
Infection, respiratory 


axetil
carboxylic acid, 3-
64544-07-6



tract, upper



([(aminocarbonyl)oxy]methyl]-7-[(2-








furanyl(methoxyimino)acetyl]amino]-8-








oxo-, 1-(acetyloxy)ethyl ester, [6R-








[6Alpha,7β(Z)]]-[CAS]







cefuroxime
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
55268-75-2
GB
1453049
Cephalosporin, 
Infection, general



carboxylic acid, 3-
56238-63-2


injectable




[[(aminocarbonyl)oxy]methyl]-7-[[2-








furanyl(methoxyimino)acetyl]amino]-8-








oxo-, [6R-[6Alpha,7β(Z)]]-[CAS]







Cefuzonam

82219-78-1






celecoxib
Benzenesulfonamide, 4-(5-(4-
169590-42-5
U.S.
5,760,068
Antiarthritic, other
Arthritis, rheumatoid



methylphenyl)-3-(trifluoromethyl)-1H-








pyrazol-1-yl)-[CAS]







celgosivir
Butanoic acid, octahydro-1,7,8-
121104-96-9
U.S.
5,017,563
Antiviral, other
Infection, hepatitis 



trihydroxy-6-indolizinyl ester, [1S-




virus, general



(1Alpha,6β,7Alpha,8β,8aβ)]-[CAS]







celiprolol
Urea, N′-[3-acetyl-4-[3-[(1,1-
56980-93-9
GB
1441359
Antihypertensive, 
Angina, unstable



dimethylethyl)amino]-2-
57470-78-7


adrenergic




hydroxypropoxy]phenyl]-N,N-diethyl-








[CAS]







Cellulose Ethyl 

9004-58-4






Hydroxyethyl








Ether








Centchroman

31477-60-8






CEP-1347
9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-
156177-65-0
WO
9731002
Antiparkinsonian
Parkinson's disease



kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-








carboxylic acid, 5,16-








bis((ethylthio)methyl)-2,3,9,10,11,12-








hexahydro-10-hydroxy-9-methyl-1-oxo-,








methyl ester, (9S,10R,12R)-[CAS]







CEP-701
9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′, 1′-
111358-88-4


Anticancer, 
Cancer, prostate



kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-



antimetabolite




one, 2,3,9,10,11,12-hexahydro-10-








hydroxy-10-(hydroxymethyl)-9-methyl-,








(9S,10S,12R)-[CAS]







Cephacetrile

23239-41-0






Cephaeline

483-17-0






Cephalexin

15686-71-2






Cephaloglycin

3577-1-3






Cephaloridine

50-59-9






Cephalo-

61-24-5






sporin C








Cephalothin

153-61-7






Cephapirin

24356-60-3






Cephradine

38821-53-3






Cerivastatin

145599-86-6






Ceronapril

111223-26-8






certoparin
Heparin [CAS]
9005-49-6


Anticoagulant
Thrombosis, venous


Ceruletide

17650-98-5






Cerviprost
Prosta-5,13-dien-1-oic acid, 11,15-
363-24-6


Formulation, dermal, 




dihydroxy-9-oxo-, (5Z,11Alpha,13E,-



topical




15S)-[CAS]







Cetalkonium

122-18-9






Cetamolol

34919-98-7






Cethexonium

1794-74-7






cethromycin
2H-Oxacyclotetradecino(4,3-d)oxazole-
205110-48-1
EP
929563
Macrolide antibiotic
Infection, respiratory 



2,6,8,14(1H,7H,9H)-tetrone 4-




tract, general



ethyloctahydro-3a,7,9,11,13,15-








hexamethyl-11-((3-(3-quinolinyl)-2-








propenyl)oxy)-10-((3,4,6-trideoxy-3-








(dimethylamino)-β-D-xylo-








hexapyranosyl)oxy)-,(3aS,








4R,7R,9R,10R,11R,13R,15R,15aR)-








[CAS]







Cetiedil

14176-10-4






Cetirizine

83881-51-0






cetirizine
Acetic acid, [2-[4-[(4-
83881-51-0
EP
58146
Antiallergic, non-asthma
Allergy, general



chlorophenyl)phenylmethyl]-1-
83881-52-1







piperazinyl]ethoxy]-, [CAS]







cetirizine +
Acetic acid, [2-[4-[(4-
83881-52-1


Formulation, 
Allergy, general


pseudo-
chlorophenyl)phenylmethyl]-1-
90-82-4


optimized,



ephedrine
piperazinyl]ethoxy]-, dihyrochloride,



microencapsulate




Benzenemethanol, Alpha-[1-








(methylamino)ethyl]-, hydrochloride, [S-








(R*R*)]-







Cetotiamine

137-76-8






Cetoxime

25394-78-9






cetraxate
Benzenepropanoic acid, 4-[[[4-
27724-96-5
JP
48075547
Antiulcer




(aminomethyl)cyclohexyl]carbonyl]oxy]-,
34675-84-8







trans-[CAS]







Cetrimonium

57-09-0






Cetrorelix

120287-85-6






Cetyldimethyl-

124-03-8






ethylammonium








Cetylpyridinium

123-03-5






cevimeline
Spiro[1-azabicyclo[2.2.2]octane-3,5′-
107220-27-9
EP
205247
Stomatological
Sjogren′s syndrome



[1,3]oxathiolane], 2-methyl-, cis-[CAS]
107233-08-9






CG-1521
7-phenyl-2,4,6-



Anticancer, other
Cancer, general



heptatrienoythydroxamic acid







Chaulmoogric 

29106-32-9






Acid








Chenodiol

474-25-9






CHF-3381


EP
951465
Analgesic, other
Pain, neuropathic


Chlophedianol

791-35-5






Chloracizine

800-22-6






chloral
1,1-Ethanediol, 2,2,2-trichloro-[CAS]
302-17-0


Formulation, 
Insomnia




2218-68-0


transmucosal,





515-82-2


systemic



Chlorambucil

305-03-3






Chloramine-B

127-52-6






Chloramine-T

127-65-1






Chloramino-

121-30-2






phenamide








Chloramphenicol

56-75-7






Chlorazanil

500-42-5






Chlor-

522-18-9






benzoxamine








Chlorbetamide

97-27-8






Chlorcyclizine

82-93-9






Chlordantoin

5588-20-5






Chlordiazepoxide

58-25-3






Chlorguanide

500-92-5






Chlorhexadol

3563-58-4






chlorhexidine
2,4,11,13-
55-56-1


Formulation, other
Xerostomia, 



Tetraazatetradecanediimidamide, N,N′′-




Periodontitis



bis(4-chlorophenyl)-3,12-diimino-








[CAS]







Chlorison-

69-27-2






damine








Chlormadinone

302-22-7






Chlormerodrin

62-37-3






Chlormezanone

80-77-3






Chlormidazole

3689-76-7






Chlornaphazine

494-03-1






Chloroazodin

502-98-7






Chlorophyll

1406-65-1






Chloropred-

52080-57-6






nisone








Chloroprocaine

3858-89-7






Chloropyramine

59-32-5






Chloroquine

54-05-7






Chlorothen

148-65-2






Chlorothiazide

58-94-6






Chlorotrianisene

569-57-3 






Chloroxine

773-76-2 






Chloroxylenol

88-04-0






Chlornzotocin

54749-90-5






chlorphenamine
2-Pyridinepropanamine, Gamma-(4-
132-22-9


Formulation, modified-
Allergy, general



chlorophenyl)-N,N-dimethyl-[CAS]



release, other



Chlorphenesin

104-29-0








886-74-8






Chlorpheniramine

132-22-9






Chlorpheno-

3576-64-5






xamide








Chlorpheno-

77-38-3






xamine








Chlorphen-

461-78-9






termine








Chiorproethazine

84-01-5






Chlorproguanil

537-21-3






chlorproguanil + 
4,4′-Sulfonyldianiline + 1-(3,4-
537-21-3


Antimalarial
Infection, malaria


dapsone
Dichlorophenyl)5-isopropylbiguanide
80-08-0






Chlorpromazine

50-53-3






Chlorpropamide

94-20-2






Chlorprothixene

113-59-7






Chiorquinaidol

72-80-0






Chlortetracycline

57-62-5






Chlorthalidone

77-36-1






Chlortheno-

132-89-8






xazin(e)








Chlorzoxazone

95-25-0






Cholic Acid

81-25-4






Choline

67-48-1








2016-36-6








28319-77-9






choline 
Ethanaminium, 2-hydroxy-N,N,N-
4499-40-5


Formulation, modified-



theophyllinate
trimethyl-, salt with 3,7-dihydro-1,3-



release, other




dimethyl-1H-purine-2,6-dione (1:1)








[CAS]







choline-L-
Ethanaminium, 2-[[(2,3-
28319-77-9
JP
55028955
Cognition enhancer
Amnesia


alfoscerate
dihydroxypropoxy)hydroxyphos-








phinyl]xy]-N,N,N-trimethyl-, hydroxide,








inner salt, (R)-[CAS]







Chromocarb

4940-39-0






Chromonar

804-10-4






Chrysoidine

532-82-1






CHS-828
Guanidine, N-[6-(4-
200484-11-3
U.S.
5,696,140
Anticancer, other
Cancer, general



chlorophenoxy)hexyl]-N′-cyano-N′′-4-








pyridinyl-[CAS]







Cl-1031
Glycine, N-[2-[5-(aminoiminomethyl)-2-
183305-24-0
WO
9638421
Antianginal
Angina, unstable



hydroxyphenoxy]-6-[3-(4,5-dihydro-1-








methyl-1H-imidazol-2-yl)phenoxy]-3,5-








difluoro-4-pyridinyl]-N-methyl-[CAS]







Cl-1040
Benzamide, 2-[(2-chloro-4-
212631-79-3
WO
9837881
Anticancer, other
Cancer, general



iodophenyl)amino]-N-








(cyclopropylmethoxy)-3,4-difluoro-








[CAS]







cibenzoline
1H-Imidazole, 2-(2,2-
53267-01-9
GB
1417174
Antiarrhythmic
Arrhythmia, general



diphenylcyclopropyl)-4,5-dihydro-








[CAS]







ciclesonide
Pregna-1,4-diene-3,20-dione 16,17-
126544-47-6
DE
4129535
Antiasthma
Asthma



((cyclohexylmethylene)bis(oxy))-11-








hydroxy-21-(2-methyl-1-oxopropoxy)








(11β,16Alpha) [CAS]







cicletanine
Furo[3,4-c]pyridin-7-ol, 3-(4-
82747-56-6
U.S.
4,383,998
Antihypertensive, other




chlorophenyl)-1,3-dihydro-6-methyl-,
89943-82-8







(+/−-)-[CAS]







ciclonicate
3-Pyridinecarboxylic acid, 3,3,5-
53449-58-4
DE
1910481
Vasodilator, peripheral
Cancer, lung, small 



trimethylcyclohexyl ester, trans-[CAS]




cell


ciclopirox
2(1H)-Pyridinone, 6-cyclohexyl-1-
41621-49-2
U.S.
3,883,545
Antifungal
Infection, fungal, 



hydroxy-4-methyl-, [CAS]
29342-05-0



general


Ciclosidomine

66564-16-7






ciclosporin A
Cyclosporin A-[CAS]
59865-13-3


Formulation, optimized,
Transplant rejection, 







microemulsion
general


cidofovir
Phosphonic acid, [[2-(4-amino-2-oxo-
113852-37-2
EP
253412
Antiviral, other
Infection, 



1(2H)-pyrimidinyl)-1-




cytomegalovirus



(hydroxymethyl)ethoxy]methyl]-, (S)-








[CAS]







Cifenline

53267-01-9






cilansetron
4H-Pyrido[3,2,1-jk]carbazol-11(8H)-
120635-74-7
EP
297651
GI inflammatory/
Irritable bowel 



one, 5,6,9,10-tetrahydro-10-[(2-methyl-



bowel disorders
syndrome



1H-imidazol-1-yl)methyl]-, (R)-[CAS]







Cilastatin

82009-34-5






cilazapril
6H-Pyridazino[1,2-a][1,2]diazepine-1-
88768-40-5
GB
2128984
Antihypertensive, renin 
Hypertension, 



carboxylic acid, 9-[[1-(ethoxycarbonyl)-
90139-06-3


system
general



3-phenylpropyl]amino]octahydro-10-








oxo-, [1S-[1Alpha,9Alpha(R*)]]-[CAS]







cilengitide
Cyclo(L-arginylglycyl-L-Alpha-aspartyl-
188968-51-6
EP
770622
Anticancer, other
Cancer, lung, 



D-phenylalanyl-N-methyl-L-valyl) [CAS]




non-small cell


cilnidipine
3,5-Pyridinedicarboxylic acid, 1,4-
102106-21-8







dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,
132203-70-4
EP
161877
Antihypertensive, other
Hypertension, 



2-methoxyethyl 3-phenyl-2-propenyl




general



ester-[CAS]







cilomilast
Cis-4-cyano-4-[3-(cyclopentyloxy)-4-
153259-65-5
U.S.
5,602,157
COPD treatment
Chronic obstructive



methoxyphenyl]cyclohexane-1-




pulmonary disease



carboxylic acid







cilostazol
2(1H)-Quinolinone, 6-[4-(1-cyclohexyl-
73963-72-1
GB
2033893
Antithrombotic
Peripheral vascular 



1H-tetrazol-5-yl)butoxy]-3,4-dihydro-




disease



[CAS]







Cimetidine

51481-61-9






cimetropium
3-Oxa-9-
51598-60-8
U.S.
3,853,886
Antispasmodic
Muscle spasm, 



azoniatricyclo[3.3.1.02,4]nonane, 9-




general



(cyclopropylmethyl)-7-(3-hydroxy-1-oxo-








2-phenylpropoxy)-9-methyl-, [7(S)-








(1Alpha,2β,4β,5Alpha,7β)]-[CAS]







cinacalcet
1-napthalenemethanamine,Alpha-
364782-34-3


Hormone
Hyperpara-



methyl-N-[3-[3-




thyroidism



(trifluoromethyl)phenyl]propyl]-,








(AlphaR)-,







Cinchonidine

485-71-2






Cinchonine

118-10-5






Cinchophen

132-60-5






Cinepazet

23887-41-4






Cinepazide

23887-46-9






cinepazide
Piperazine, 1-[2-oxo-2-(1-
26328-04-1
GB
1218591
Vasodilator, 
Peripheral vascular 



pyrrolidinyl)ethyl]-4-[1-oxo-3-(3,4,5-



peripheral
disease



trimethoxyphenyl)-2-propenyl]-, (Z)-2-








butenedioate (1:1) [CAS]







Cinitapride

66564-14-5






Cinmetacin

20168-99-4






Cinnamedrine

90-86-8






Cinnarizine

298-57-7






cinolazepam
1H-1,4-Benzodiazepine-1-
75696-02-5
DE
2950235
Hypnotic/Sedative
Insomnia



propanenitrile, 7-chloro-5-(2-








fluorophenyl)-2,3-dihydro-3-hydroxy-2-








oxo-[CAS]







cinoxacin
[1,3]Dioxolo[4,5-g]cinnoline-3-
28657-80-9
GB
1296753
Quinolone 
Infection, urinary 



carboxylic acid, 1-ethyl-1,4-dihydro-4-



antibacterial
tract



oxo-[CAS]







Cinoxate

104-28-9






Cinromide

58473-74-8






Cioteronel

89672-11-7






cipamfylline
1H-Purine-2,6-dione, 8-amino-1,3-
132210-43-6
EP
389282
Antipruritic/inflamm, 
Eczema, atopic



bis(cyclopropylmethyl)-3,7-dihydro-



allergic




[CAS]







cipralisant
1H-Imidazole, 4-[(1R,2R)-2-(5,5-
213027-19-1
U.S.
6,008,240
Psychostimulant
Attention deficit 



dimethyl-1-hexynyl)cyclopropyl]-[CAS]




disorder


ciprofibrate
Propanoic acid, 2-[4-(2,2-
52214-84-3
GB
1385828
Hypolipaemic/
Hyperlipidaemia, 



dichlorocyclopropyl)phenoxy]-2-methyl-



Antiatherosclerosis
general



[CAS]







ciprofloxacin
3-Quinolinecarboxylic acid, 1-
85721-33-1
U.S.
4,670,444
Quinolone 
Infection, general



cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-



antibacterial




7-(1-piperazinyl)-[CAS]







ciprofloxacin +
3-Quinolinecarboxylic acid, 1-



Formulation, 
Otitis


fluocinolone, 
cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-



fixed-dose



SAL
7-(1-piperazinyl)- + (6Alpha, 11β,



combinations




16Alpha)-6,9-Difluoro-11,21-dihydroxy-








16,17-[(1-methylethylidene)bis-(oxy)]-








pregna-1,4-diene-3,20-dione







Ciramadol

63269-31-8






cisapride
Benzamide, 4-amino-5-chloro-N-[1-[3-
81098-60-4
EP
76530
Gastroprokinetic




(4-fluorophenoxy)propyl]-3-methoxy-4-








piperidinyl]-2-methoxy-, cis-[CAS]







cisatracurium
Isoquinolinium, 2,2′-[1,5-
96946-42-8
U.S.
5,453,510
Muscle relaxant
Surgery adjunct



pentanediylbis[oxy(3-oxo-3,1-








propanediyl)]]bis[1-[(3,4-








dimethoxyphenyl)methyl]]-1,2,3,4-








tetrahydro-6,7-dimethoxy-2-methyl-,








[1R-[1Alpha,2Alpha(1′R*,2′R*)]]-, [CAS]







cispiatin
Platinum, diamminedichloro-, (SP-4-2)-
15663-27-1
U.S.
4,177,263
Anticancer, 




[CAS]



alkylating



citalopram
5-Isobenzofurancarbonitrile, 1-[3-
59729-32-7
GB
1526331
Antidepressant
Depression, general



(dimethylamino)propyl]-1-(4-
59729-33-8







fluorophenyl)-1,3-dihydro-[CAS]







citicoline
Cytidine 5-(trihydrogen diphosphate),
987-78-0
JP
39006541
Cognition enhancer
Infarction, cerebral



P′-[2-(trimethylammonio)ethyl]ester,








hydroxide, inner salt [CAS]







Citiolone

1195-16-0






Citric Acid

77-92-9






Citrulline

372-75-8






cizolirtine
Ethanamine, N,N-dimethyl-2-[(1-methyl
142155-44-0


Urological
Incontinence



1H-pyrazol-5-yl)phenylmethoxy]-, 2-








hydroxy-1,2,3-propanetricarboxylate








[CAS]







CJ-13610
4-(3-[4-(2-Methyl-imidazol-1-yl)-



COPD treatment
Chronic obstructive



phenylsulfanyl]-phenyl)-tetrahydro-




pulmonary disease



pyran-4-carboxylic acid amide







CKD-602
1H-Pyrano[3′,4′:6,7]indolizino[1,2-
213819-48-8
WO
9902530
Anticancer, other
Cancer, ovarian



b]quinoline-3,14(4H,12H)-dione, 4-








ethyl-4-hydroxy-11-[2-[(1-








methylethyl)amino]ethyl]-,








monohydrochloride, (4S)-[CAS]







cladribine
Adenosine, 2-chloro-2′-deoxy-[CAS]
4291-63-8
EP
173059
Anticancer, 
Cancer, leukaemia,







antimetabolite
hairy cell


Clanobutin

30544-61-7






clarithromycin
Erythromycin, 6-O-methyl-[CAS]
81103-11-9
EP
41355
Macrolide antibiotic
Infection, respiratory 








tract, lower


Clavulanate, 








Disodium








Clavulanic 

58001-44-8






Acid








Clebopride

55905-53-8






Clemastine

15686-51-8






Clemizole

442-52-4






Clenbuterol

37148-27-9






Clentiazem

96125-53-0 






clevidipine
3,5-Pyridinedicarboxylic acid, 4-(2,3-
16722 1-71-8
WO
9512578
Antihypertensive, 
Hypertension, 



dichlorophenyl)-1,4-dihydro-2,6-



other
general



dimethyl-, methyl (1-oxobutoxy)methyl








ester (±) [CAS]







clevudine
2,4(1H,3H)-Pyrimidinedione, 1-(2-
163252-36-6


Antiviral, other
Infection, 



deoxy-2-fluoro-β-L-arabinofuranosyl)-5-




hepatitis-B virus



methyl-[CAS]







Clidanac

28968-07-2






Clidinium

3485-62-9






Clinafloxacin

105956-97-6






Clindamycin

18323-44-9






clindamycin + 
L-threo-Alpha-D-galacto-



Formulation, 
Acne


tretinoin
Octopyranoside, methyl 7-chloro-6,7,8-



fixed-dose




trideoxy-6-[[(1-methyl-4-propyl-2-



combinations




pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-








trans)- + retinoic acid







clindamycin
L-Threo-Alpha-D-galacto
18323-44-9


Formulation, 
Infection, 



octopyranoside, methyl 7-chloro-6,7,8-
24729-96-2


parenteral, other
gynaecological



trideoxy-6-[[(1-methyl-4-propyl-2-








pyrrolidinyl)carbonyl]amino]-1-thio-, 2-








(dihydrogen phosphate), (2S-trans)-







Clinofibrate

30299-08-2






Clinprost

88931-51-5






clobazam
1H-1,5-Benzodiazepine-2,4(3H,5H)-
22316-47-8
GB
1214662
Anxiolytic




dione, 7-chloro-1-methyl-5-phenyl-








[CAS]







Clobenfurol

3611-72-1






Clobenoside

29899-95-4






Clobenzepam

1159-93-9






Clobenzorex

13364-32-4






Clobenztropine

5627-46-3






clobetasol
Pregna-1,4-diene-3,20-dione, 21-
25122-41-2


Formulation, 
Psoriasis



chloro-9-fluoro-11,17-dihydroxy-16-



dermal, topical




methyl-, (11β,16β)-[CAS]







clobetasone
Pregna-1,4-diene-3,11,20-trione, 21-
25122-57-0
GB
1253831
Antipruritic/inflamm, 




chloro-9-fluoro-16-methyl-17-(1-
54063-32-0


allergic




oxobutoxy)-, (16β)-[CAS]







Clobutinol

14860-49-2






Clocapramine

47739-98-0






Clocinizine

298-55-5






Cloconazole

77175-51-0






Clocortolone

4828-27-7






clodronate
Phosphonic acid,
22560-50-5


Osteoporosis treatment, 
Pain, cancer,



(dichloromethylene)bis-[CAS]



Anticancer, hormonal
Hypercalcaemia of








malignancy


Clodronic 

10596-23-3






Acid








clofarabine
2-chloro-9-(2-deoxy-2-fluoro-β-D-



Anticancer, 
Cancer, leukaemia, 



arabinofurasonyl)adenine



antimetabolite
chronic








lymphocytic


clofazimine
3-(p-chloroanilo)-10-(p-chlorophenyl)-
2030-63-9


Formulation, 
Infection, 



2,10-dihydro-2-(isopropylimino)-



optimized,
tuberculosis



phenazine



microencapsulate



Clofenamide

671-95-4






Clofibrate

637-07-0






Clofibric Acid

882-09-7






Cloflucarban

369-77-7






Clofoctol

37693-01-9






Cloforex

14261-75-7






Clomacran

5310-55-4






Clomestrone

4091-75-2






Clometacin

25803-14-9






Clomethiazole

533-45-9






Clometocillin

1926-49-4






Clomiphene

911-45-5






Clomipramine

303-49-1






Clomocycline

1181-54-0






clonazepam
2H-1,4-Benzodiazepin-2-one, 5-(2-
1622-61-3
U.S.
4,316,897
Antiepileptic
Epilepsy, general



chlorophenyl)-1,3-dihydro-7-nitro-








[CAS]







clonidine
1H-Imidazol-2-amine, N-(2,6-
4205-90-7
U.S.
4,060,084
Formulation, 
Hypertension, 



dichlorophenyl)-4,5-dihydro-[CAS]



transdermal, patch
general


Clonitazene

3861-76-5






Clonitrate

2612-33-1






Clonixin

17737-65-4






Clopamide

636-54-4






Clopenthixol

982-24-1






Cloperastine

3703-76-2






clopidogrel
Thieno[3,2-c]pyridine-5(4H)-acetic
120202-48-4
EP
99802
Antithrombotic
Infarction, 



acid, Alpha-(2-chlorophenyl)-6,7-
90055-48-4



myocardia



dihydro-, methyl ester, (S)-[CAS]
113665-84-2






Clopirac

42779-82-8






Cloprednol

5251-34-3






cloranolol
2-Propanol, 1-(2,5-dichlorophenoxy)-3-
39563-28-5
U.S.
4,310,549
Antihypertensive, 




[(1,1-dimethylethyl)amino]-[CAS]
54247-25-5


adrenergic



Clorazepic Acid

23887-31-2






Clorexolone

2127-1-7






cloricromene
Acetic acid, [[8-chloro-3-[2-
68206-94-0
U.S.
4,349,566
Vasodilator, coronary
Peripheral vascular 



(diethylamino)ethyl]-4-methyl-2-oxo-2H-




disease



1-benzopyran-7-yl]oxy]-, ethyl ester








[CAS]







Clorindione

1146-99-2






Clorprenaline

3811-25-4






Clortermine

10389-73-8






Clospirazine

24527-27-3






Clostebol

1093-58-9






Clothiapine

2058-52-8






clotiazepam
2H-Thieno[2,3-e]-1,4-diazepin-2-one, 5-
33671-46-4
U.S.
3,849,405
Anxiolytic
Anxiety, general



(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-








methyl-[CAS]







clotrimazole
1-[(2-chlorophenyl)diphenylmethyl]-1H-
23593-75-1
U.S.
3,705,172
Antifungal




imidazole







clotrimazole +
Pregna-1,4-diene-3,20-dione, 9-fluoro-
92522-91-3


Formulation, 
Infection, fungal, 


betamethasone
11-hydroxy-16-methyl-17,21-bis(1-



fixed-dose
general



oxopropoxy)-, (11β,16β)-, mixt. with 1-



combinations




[(2-chlorophenyl)diphenylmethyl]-1H-








imidazole [CAS]







Cloxacillin

61-72-3






cloxazolam
Oxazolo[3,2-d][1,4]benzodiazepin-
24166-13-0
U.S.
3,772,371
Anxiolytic




6(5H)-one, 10-chloro-11b-(2-








chlorophenyl)-2,3,7, 11b-tetrahydro-








[CAS]







Cloxotesto-

53608-96-1






sterone








Cloxyquin

130-16-5






clozapine
5H-Dibenzo[b,e] 1,4]diazepine, 8-
5786-21-0
U.S.
3,539,573
Neuroleptic
Schizophrenia



chloro-11-(4-methyl-1-piperazinyl)-








[CAS]







CMI-392
Trans-2-[3-methoxy-4-(2-p-
193739-23-0
U.S.
5,648,486
Antipsoriasis
Psoriasis



chlorophenylthio)ethoxy-5-(N-methyl-








N′-hydroxyureidyl)methylphenyl]-5-








(3,4,5-








trimethoxyphenyl)tetrahydrofuran







CMT-3
2-Naphthacenecarboxamide,
15866-90-7
U.S.
5,837,696
Anticancer, other
Cancer, sarcoma, 



1,4,4a,5,5a,6,11,12a-octahydro-




Kaposi's



3,10,12,12a-tetrahydroxy-1,11-dioxo-,








(4a5,5aR,12a5)-[CAS]







CNI-1493
Decanediamide, N,N-bis[3,5-bis[1-
164301-51-3
U.S.
5,750,573
Anti-inflammatory
Psoriasis



[(aminoiminomethyl)hydrazono]ethyl]








phenyl]-, tetrahydrochloride [CAS]







CNS-5161
N-[2-chloro-5-(methylthio)phenyl]-N-
160754-76-7
WO
9427591
Analgesic, other
Pain, neuropathic



methyl-N-[3-








(methylthio)phenyl]guanidine [CAS]







Cobamamide

13870-90-1






Cocaethylene

529-38-4






Cocaine

50-36-2






Codeine

76-57-3








52-28-8






CoFactor
5,10 methylene - tetrahydrofolate



Anticancer, 
Cancer, colorectal







antimetabolite



Colchicine

64-86-8






colesevelam
1-Hexanaminium, N,N,N-trimethyl-6-(2-
182815-44-7
U.S.
5,607,669
Hypolipaemic/
Hyperlipidaemia, 



propenylamino)-, polymer with



Antiatherosclerosis
general



(chloromethyl)oxirane, 2-propen-1-








amine and N-2-propenyl-1-








decanamine, hydrochloride [CAS]







colestilan
1H-Imidazole, 2-methyl-, polymer with
95522-45-5
JP
59155421
Hypolipaemic/
Hypercholesterol-



(chloromethyl)oxirane [CAS]



Antiatherosclerosis
aemia


Colestipol

26658-42-4






colforsin 
6-(3-dimethylaminopropionyl)forskolin-
138605-00-2
EP
222413
Cardiostimulant
Heart failure


daropate
[CAS]







colfosceril
3,5,9-Trioxa-4-phosphapentacosan-1-
63-89-8
U.S.
4826821
Lung Surfactant
Respiratory distress



aminium, 4-hydroxy-N,N,N-trimethyl-10
99732-49-7



syndrome, infant



oxo-7-[(1-oxohexadecyl)oxy]-,








hydroxide, inner salt, 4-oxide, (R)-








[CAS]







Collagraft

138331-02-9


Formulation, implant
Regeneration, bone


Colocynthin

1398-78-3






Colpormon

1247-71-8






coluracetam
1-Pyrrolidineacetamide, 2-oxo-N-
135463-81-9
EP
427636
Cognition enhancer
Alzheimer's disease



(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-








b]quinolin-4-yl)-[CAS]







combretastatin
disodium combretastatin-A-4-3-O-



Anticancer, other
Cancer, thyroid


A-4 prodrug
phosphate







compound 


U.S.
6,362,165
Antiviral, anti-HIV
Infection, HIV/AIDS


B, Pharmacor








conivaptin
[1,1′-Biphenyl]-2-carboxamide, N-[4-
168626-94-6
WO
9503305
GI inflammatory/
Hyponatraemia



[(4,5-dihydro-2-methylimidazo[4,5-d][1-



bowel disorders




benzazepin-6(1H)-yl)carbonyl]phenyl]-,








[CAS]







Connettivina
Hyaluronic acid [CAS]
9004-61-9


Vulnerary



Convallatoxin

508-75-8






Coparaffinate

8001-60-3






Corticorelin 








Ovine 








Triflutate








Corticosterone

50-22-6






Cortisone

53-06-5






Cortivazol

1110-40-3






Cosyntropin

16960-16-0






Cotarnine

82-54-2






Cotinine

486-56-6






co-trimazine
Benzenesulfonamide, 4-amino-N-2-
39474-58-3


Trimethoprim and 
Infection, urinary 



pyrimidinyl-, mixt. with 5-[(3,4,5-



analogues
tract



trimethoxyphenyl)methyl]-2,4-








pyrimidinediamine [CAS]







Coumetarol

4366-18-1






CP-248
1H-Indene-3-acetamide, 5-fluoro-2-
200803-37-8
WO
9747303
Anticancer, other
Barrett's 



methyl-N-(phenylmethyl)-1-[(3,4,5-




oesophagus



trimethoxyphenyl)methylene]-, (1Z)-








[CAS]







CP-461


U.S.
5,948,779
Anticancer, other



CPC-211
Acetic acid, dichloro-, sodium salt
2156-56-1


Neuroprotective
Acidosis, lactic



[CAS]







CPI-1189
CPI 1189 [CAS]
210475-67-5
WO
9631462
Cognition enhancer
Dementia, AIDS-








related


CRA-0450


WO
0202549
Anxiolytic
Unspecified


creatinol-O-
Guanidine, N-methyl-N-[2-
6903-79-3


Antianginal



phosphate
(phosphonooxy)ethyl]-[CAS]







CRL-5861
Oxirane, methyl-, polymer with oxirane,
106392-12-5
U.S.
4,837,014
Antisickling




block [CAS]







crobenetine
(2R,65)-3-[2(S)-Benzyloxypropyl]-

WO
9914199
Neuroprotective
Ischaemia, cerebral



6,11,11-trimethyl-1,2,3,4,5,6,-








hexahydro-2,6-methano-3-benzazocin-








10-ol







croconazole
1H-Imidazole, 1-[1-[2-[(3-
77175-51-0
DE
3021467
Antifungal
Infection, funcal, 



chlorophenyl)methoxy]phenyl]ethenyl]-




general



[CAS]







cromoglicic 
4H-1-Benzopyran-2-carboxylic acid,
53736-52-0


Formulation, mucosal, 
Conjunctivitis


acid
5,5′-[(2-hydroxy-1,3-



topical




propanediyl)bis(oxy)]bs4-oxo-[CAS]







cromolyn
4H-1-Benzopyran-2-carboxylic acid,
15826-37-6


Formulation, inhalable, 
Asthma



5,5′-[(2-hydroxy-1,3-
16110-51-3


solution




propanediyl)bis(oxy)]bis[4-oxo-, [CAS]







Cropropamide

633-47-6






Crotamiton

483-63-6






Crotethamide

6168-76-9






Crystacide


U.S.
4,557,935
Formulation, dermal, 
Infection, 







topical
dermatological


CS-502
□

EP
799823
Analgesic, other
Pain, general


CS-758
4-[(1E,3E)-4-[trans-5-[[1R,2R)-2-(2,4-



Antifungal
Infection, fungal, 



difluorophenyl)-2-hydroxy-1-methyl-3-




general



(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-








dioxan-2-yl]-1,3-butadienyl]-3-








fluorobenzonitrile







CS-834
1-Azabicyclo[3.2.0]hept-2-ene-2-
157542-49-9 
EP
599512
Beta-lactam 
Infection, general



carboxylic acid, 6-[(1R)-1-hydroxyethyl]-



antibiotic




4-methyl-7-oxo-3-[[(3R)-5-oxo-3-








pyrrolidinyl]thio]-, (2,2-dimethyl-1-








oxopropoxy)methyl ester, (4R,5S,6S)-








[CAS]







CT-052923
[(2H-benzo[d]1,3-dioxalan-5-



Cardiovascular
Restenosis



methyl)amino][4-(6,7-








dimethoxyquinazolin-4-








yl)piperazinyl]methane-1-thione







CT-32228
N-(4-bromophenyl)-6-(5-chloro-2-



Anticancer, other
Cancer, general



methylphenyl)-[1,3,5]triazine-2,4-








diamine







Cupric Citrate

866-82-0






Cuproxoline

13007-93-7






CVT-2584
Ethanol, 2,2′-[[6-[[(4-
199986-75-9
WO
9805335
Cardiovascular
Restenosis



methoxyphenyl)methyl]amino]-9-(1-








methylethyl)-9H-purin-2-yl]imino]bis-








[CAS]







CX-659S
((S)-6-amino-5-(6-hydroxy-2,5,7,8-



Dermatological
Eczema, general



tetramethylchroman-2-carboxamido)-3-








methyl-1-phenyl-2,4-(1H,3H)-








pyrmidinedione







Cyacetacide

140-87-4






Cyamemazine

3546-03-0






Cyanidin

528-58-5






CYC400


WO
00172745
Anticancer, other
Cancer, general


Cyclacillin

3485-14-1






Cyclandelate

456-59-7






Cyclazocine

3572-80-3






Cyclexanone

15301-52-7






Cyclexedrine

532-52-5






cyclidrol
3-Cyclohexene-1-methanol, 5-hydroxy-
498-71-5


COPD treatment, 
Bronchitis, chronic



Alpha,Alpha,4-trimethyl-[CAS]



Respiratory



cyclin D1 


U.S.
6,033,843
Anticancer, hormonal
Cancer, breast


inhibitors








Cyclizine

82-92-8






Cyclobarbital

52-31-3






Cyclobendazole

31431-43-3






cyclobenzaprine
1-Propanamine, 3-(5H-
303-53-7


Formulation, modified-
Muscle spasm, 



dibenzo[a,d]cyclohepten-5-ylidene)-



release, other
general



N,N-dimethyl-[CAS]







Cyclobutyrol

512-16-3






Cyclocumarol

518-20-7






Cyclodrine

52109-93-0






Cyclofenil

2624-43-3






Cycloguanil

516-21-2






Cyclomethy-

139-62-8






caine








Cyclonium 

6577-41-9






Iodide








Cyclopent-

102-45-4






amine








Cyclopen-

742-20-1






thiazide








Cyclopento-

76-68-6






barbital








Cyclopentolate

512-15-2






cyclophos-
N,N-Bis(2-chloroethyl)tetrahydro-2H-
50-18-0


Formulation, parenteral, 
Cancer, general


phamide
1,3,2-oxazaphosphorin-2-amine-2-
6055-19-2


targeted




oxide monohydrate







cyclopirox-
2(1H)-Pyridinone, 6-cyclohexyl-1-
41621-49-2


Formulation, 
Vaginitis


alamine
hydroxy-4-methyl-, cmpd with 2-



transdermal, other




aminoethanol(1:1) [CAS]







Cycloserine

68-41-7






Cyclothiazide

2259-96-3






Cyclovalone

579-23-7






Cymarin

508-77-0






cymserine
Carbamic acid, [4-(1-
145209-39-8
WO
9902154
Cognition enhancer
Alzheimer's 



methylethyl)phenyl]-, (3aS,8aR)-




disease



1,2,3,3a,8,8a-hexahydro-1,3a,8-








trimethylpyrrolo[2,3-blindol-5-yl ester








[CAS]







Cynarin(e)

30964-13-7






CYP26 inhibitors


U.S.
6,063,606
Dermatological
Unspecified


Cyproheptadine

129-03-3






cyproterone
(1β,2β)-6-Chloro-1,2-dihydro-17-
2098-66-0


Radio/
Chemotherapy-



hydroxy-3H-cyclopropa[1,2]pregna-



chemoprotective
induced injury, 



1,4,6-triene-3,20-dione [CAS]




general


Cysteamine

60-23-1






cystic fibrosis 
[[4-[[3-[[4-[1-(4-hydroxyphenyl)-1-



Cystic fibrosis 
Cystic fibrosis


ther
methyl-



treatment




ethyl]phenoxy]methyl]phenyl]methoxy]-








phenyl]iminomethyl]-, ethyl ester







cytarabine
2(1H)-Pyrimidinone, 4-amino-1-[5-O-
65093-40-5
EP
239015
Anticancer, 
Myelodysplastic 



[hydroxy(octadecyloxy)phosphinyl]-β-D-
147-94-4


antimetabolite
syndrome



arabinofuranosyl]-, [CAS]







D-24851
N-(Pyridin-4-yl)-(1-(4-chlorobenzyl)-



Anticancer, other
Cancer, general



indol-3-yl)-glyoxyl-amide)







D-4418
8-Methoxyquinoline-5-[N-(2,5-



Antiasthma
Asthma



dichloropyridin-3-yl)]carboxamide







DA-5018
Benzeneacetamide, 4-(2-aminoethoxy)-
174661-97-3
U.S.
5,242,944
Analgesic, other
Pain, 



N-(3-(3,4-dimethylphenyl)propyl)-3-




musculoskeletal



methoxy-, monohydrochloride [CAS]







DA-6034


U.S.
6,025,387
GI inflammatory/
Crohn's disease







bowel disorders



DA-7867


KR
9957803
Antibacterial, other
Infection, general


DA-7911


KR
56034
Antiarthritic, other
Arthritis, 








rheumatoid


DA-8159
3-(1-Methyl-7-oxo-3-propyl-6,7-dihydro-

KR
353014
Male sexual 
Sexual dysfunction, 



1H-pyrazolo-[4,3-d]pyrimidin-5-yl)-N-[2-



dysfunction,
male, general



(1-methylpyrrolidin-2-yl)ethyl]-4-








propoxybenzenesulfonamide







Dacarbazine

4342-3-4






Daclizumab

152923-56-3






Dactinomycin

50-76-0






dalbavancin
5,31-Dichloro-38-de(methoxycarbonyl)-
171500-79-1


Peptide antibiotic
Infection, 



7-demethyl-1 9-deoxy-56-O-[2-deoxy-2-




dermatological



(10-methylundecanamido)-β-D-








glucopyranurosyl]-38-[N-[3-








(dimethylamino)propyl]carbamoyl]-42-








O-Alpha-D-mannopyranosyl-N15-








methylristomycin A aglycone







Dalfopristin

112362-50-2






dalfopristin +
Virginiamycin M1, 26-((2-
126602-89-9
EP
248703
Antibiotic, other
Infection, respiratory 


quinupristin
(diethylamino)ethyl)sulfonyl)-26,27-




tract, general



dihydro-, (26R,27S)-, mixt with 4-(4-








(dimethylamino)-N-methyl-L-








phenylalanine)-5-(5-((1-








azabicyclo(2.2.2)oct-3-ylthio)methyl)-4-








oxo-L-2-pipendinecarboxylic acid)








virginiamycin S1-[CAS]







dalteparin
Heparin-, [CAS]
9041-08-1
U.S.
4,303,651
Anticoagulant
Thromboprophylaxis


Daltroban

79094-20-5






d-Aminole-

106-60-5






vulinic 








Acid








danaparoid


EP
66908
Anticoagulant
Thrombosis, venous


danazol
Pregna-2,4-dien-20-yno[2,3-d]isoxazol-
17230-88-5
GB
905844
Menstruation 




17-ol, (17Alpha)-[CAS]



disorders



Danthron

117-10-2






Dantrolene

7261-97-4






dapiprazole
1,2,4-Triazolo[4,3-a]pyridine, 5,6,7,8-
72822-12-9
U.S.
4,252,721
Ophthalmological
Glaucoma



tetrahydro-3-[2-[4-(2-methylphenyl)-1-
72822-13-0







piperazinyl]ethyl]-[CAS]







dapivirine
4-[[4-(2,4,6-
244767-67-7


Antiviral, anti-HIV
Infection, 



trimethylphenyl)amino]pyrimidin-2-




HIV/AIDS



yl]amino]benzonitrile







dapoxetine
(+)-(S)-N,N-dimethyl-Alpha-[2-(1-
119356-77-3
EP
288188
Male sexual 
Premature 



naphthyl-oxy)ethyl]benzylamine HCl



dysfunction
ejaculation


dapsone
4,4′-Sulfonyldianiline
80-08-0


Formulation, dermal, 
Acne







topical



daptomycin
Daptomycin [CAS]
103060-53-3
EP
178152
Peptide antibiotic
Infection, 








dermatological


Darbepoetin 








Alfa








darifenacin
3-Pyrrolidineacetamide, 1-[2-(2,3-
133099-04-4
EP
388054
Urological
Overactive bladder



dihydro-5-benzofuranyl)ethyl]-








Alpha,Alpha-diphenyl-, (S)-[CAS]







daunorubicin
5,12-Naphthacenedione, 8-acetyl-10-
20830-81-3
U.S.
5,441,745
Formulation, 
Cancer, sarcoma, 



[(3-amino-2,3,6-trideoxy-Alpha-L-lyxo-



optimized, 
Kaposi's



hexopyranosyl)oxy]-7,8,9,10-tetrahydro-



liposomes




6,8,11-trihydroxy-1-methoxy-, (8S-cis)-








[CAS]







DAX, SciClone
3-diallyl-8-cyclohexylxanthine



Cystic fibrosis 
Cystic fibrosis







treatment



DB-67
7-tert-Butyldimethylsiiyl-10-







hydroxy-




Anticancer, other
Cancer, general


camptothecin








d-Camphocarbo-

18530-30-8






xylic Acid








DCF-987
Dextran

U.S.
5,514,665
Formulation, other
Cystic fibrosis


DDT

50-29-3






Deamino-

113-78-0






oxytocin








Deanol

108-01-0






Debrisoquin

1131-64-2






Decamethonium

541-22-0






Decimemide

14817-09-5






decitabine
1,3,5-Triazin-2(1H)-one, 4-amino-1-(2-
23339-46-0


Anticancer, 
Myelodysplastic 



deoxy-β-D-erythro-pentofuranosyl)-
2353-33-5


antimetabolite
syndrome



[CAS]







declopramide
Benzamide, 4-amino-3-chloro-N-(2-
891-60-1
WO
9732582
Anticancer, other
Cancer, colorectal



(diethylamino)ethyl)-[CAS]







Deferiprone

30652-11-0






Deferoxamine

70-51-9






deflazacort
5′H-Pregna-1,4-dieno[17,16-d]oxazole-
14484-47-0
GB
1077393
Hormone
Asthma



3,20-dione, 21-(acetyloxy)-11-hydroxy-
74712-90-6







2′-methyl-, (11β,16β)-[CAS]







Defosfamide

3733-81-1






degarelix
N-acetyl-3-(naphtalen-2-yl)-D-alanyl-4-
214766-78-6


Anticancer, hormonal
Cancer, prostate



chloro-D-phenylalanyl-3-(pyridin-3-yl)-








D-alanyl-L-seryl-4-[[[(4S)-2,6-








dioxohexahydropyrimidin-4-








yl]carbonyl]amino]-L-phenylalanyl-4-








(carbamoylamino)-D-phenylalanyl-L-








leucyl-N6-(1-methylethyl)-L-lysyl-L-








prolyl-D-alaninamide







dehydro-
L-threo-2,3-Hexodiulosonic acid
490-83-5


Cognition enhancer
Alzheimer's disease


ascorbic acid
gamma-lactone







Dehydro-

81-23-2






cholic 








Acid








Dehydro-

4914-30-1






emetine








delapril
Glycine, N-(2,3-dihydro-1H-inden-2-yl)-
83435-66-9
EP
51391
Antihypertensive, renin 
Hypertension, 



N-[N-[1-(ethoxycarbonyl)-3-
83435-67-0


system
general



phenylpropyl]-L-alanyl]-, (S)-[CAS]







delapril + 
Glycine, N-(2,3-dihydro-1H-inden-2-yl)-

FR
2733911
Formulation, fixed-
Hypertension, 


manidipine
N-[N-[1-(ethoxycarbonyl)-3-



dose combinations
general



phenylpropyl]-L-alanyl]-, (S)-3,5-








Pyridinedicarboxylic acid, 1,4-dihydro-








2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-








(diphenylmethyl)-1-piperazinyl]ethyl








methyl ester [CAS]







delavirdine
Piperazine, 1-[3-[(1-methylethyl)amino]-
136817-59-9
WO
9109849
Antiviral, anti-HIV
Infection, 



2-pyridinyl]-4-[[5-




HIV/AIDS



[(methylsulfonyl)amino]-1H-indol-2-








yl]carbonyl]-[CAS]







Delmadinane

13698-49-2






Delmopinol

79874-76-3






delorazepam
2H-1,4-Benzodiazepin-2-one, 7-chloro-
2894-67-9
CH
408029
Anxiolytic




5-(2-chlorophenyl)-1,3-dihydro-[CAS]







delucemine
3,3-Bis-(m-fluorophenyl)-N-
186495-99-8


Neuroprotective
Ischaemia, cerebral



methylpropylamine [CAS]







Demanyl

6909-62-2






Demecarium

56-94-0






demeclocycline
2-Naphthacenecarboxamide, 7-chloro-
127-33-3


Formulation, modified-
Infection, general



4-(dimethylamino)-



release, <=24 hr




1,4,4a,5,5a,6,11,12a-octahydro-








3,6,10,12,12a-pentahydroxy-1,11-dioxo-,








[4S-(4Alpha,4aAlpha,5aAlpha,6a,12aAl-








pha)]-[CAS]







Demecolcine

477-30-5






Demegestone

10116-22-0






Demexiptiline

24701-51-7






denaverine
Benzeneacetic acid, Alpha-(2-
3321-06-0
DE
4133785
Analgesic, NSAID
Pain, 



ethylbutoxy)-Alpha-phenyl-, 2-




musculoskeletal



(dimethylamino)ethyl ester, [CAS]







Denileukin 

173146-27-5






Diftitox








Denopamine

71771-90-9






Denopterin

22006-84-4






Deoxycholic 

83-44-3






Acid








Deoxy-

64-85-7






corticosterone

56-47-3






Deoxydi-

26086-49-7






hydrostrepto-








mycin








Deoxyepine-

501-15-5






phrine








Depreotide

161982-62-3 






depsipeptide
L-Valine, N-[(3S,4E)-3-hydroxy-7-
128517-07-7
EP
352646
Anticancer, antibiotic
Cancer, general



mercapto-1-oxo-4-heptenyl]-D-valyl-D-








cysteinyl-(2Z)-2-amino-2-butenoyl-, (4-








1)-lactone, cyclic (1-2)-disulfide [CAS]







Deptropine

604-51-3






Dequalinium

522-51-0






dersalazine
Benzoic acid, 2-hydroxy-5-[[4-[3-[4-(2-
188913-57-7
U.S.
5,747,477
Anti-inflammatory




methyl-1H-imidazol[4,5-c]pyridin-1-
188913-58-8







yl]methyl]-1-piperidinyl]-3-oxo-1-phenyl-








1-propenyl]phenyl]azo] (Z) [CAS]







Deserpidine

131-01-1






desferri-
Butanediamide, N′-[5-[[4-[[5-
70-51-9


Antidote
Poisoning, metal


oxamine
(acetylhydroxyamino)pentyl]amino]-1,4-








dioxobutyl]hydroxyamino]pentyl]-N-(5-








aminopentyl)-N-hydroxy-[CAS]







Desflurane

57041-67-5






Desipramine

50-47-5






Deslanoside

17598-65-1






desloratadine
5H-Benzo(5,6)cyclohepta(1,2-
100643-71-8
U.S.
5,595,997
Antiallergic, non-
Rhinitis, allergic, 



b)pyridine, 8-chloro-6, 11-dihydro-11-(4-



asthma
perennial



piperidinylidene)-[CAS]







deslorelin
Luteinizing hormone-releasing factor
57773-65-6
U.S.
4,034,082
Releasing hormone
Cancer, prostate



(pig), 6-D-tryptophan-9-(N-ethyl-L-








prolinamide)-10-deglycinamide-[CAS]







desmopressin
Vasopressin, 1-(3-mercaptopropanoic
16679-58-6
DE
2948345
Hormone
Enuresis



acid)-8-D-arginine-[CAS]







Desogestrel

54024-22-5






desogestrel +
Estra-1,3,5(10)-triene-3,17-diol (17β)-,
122364-17-4


Menopausal disorders
Hormone 


estradiol
mixt. with (17Alpha)-13-ethyl-11-




replacement



methylene-18,19-dinorpregn-4-en-20-




therapy



yn-17-ol [CAS]







desogestrel,
18,19-Dinorpregn-4-en-20-yn-17-ol, 13-
54024-55-5


Formulation, oral, 
Contraceptive, 


Akzo Nobel
ethyl-11-methylene-, (17Alpha)-[CAS]



other
female


desogestrel +
18,19-Dinorpregn-4-en-20-yn-17-ol, 13-
54024-22-5
U.S.
3,927,046
Formulation, oral, 
Contraceptive, 


ethinylestrad (1)
ethyl-11-methylene-, (17Alpha)-[CAS]
71138-35-7


other
female


Desomorphine

427-00-9






Desonide

638-94-8






Desoxi-

382-67-2






metasone








Detaxtran

9015-73-0






Devacade


WO
9308176
Analgesic, other
Pain, general


dexamethasone
Pregna-1,4-diene-3,20-dione,9-fluoro-
50-02-2


Formulation, other
Inflammation, 



11,17,21-trihydroxy-16-methyl-,
2392-39-4



ocular



(11β,16Alpha)-[CAS]
312-93-6






dexanabinol
6H-Dibenzo[b,d]pyran-9-methanol, 3-
112924-45-5
EP
427518
Neuroprotective
Head trauma



(1,1-dimethylheptyl)-6a,7,10,10a-








tetrahydro-1-hydroxy-6,6-dimethyl-,








(6aS-trans)-[CAS]







dexecadotril
Glycine, N-[2-[(acetylthio)methyl]-1-oxo-
112573-72-5
EP
318377
Alimentary/
Unspecified



3-phenylpropyl]-, phenylmethyl ester,



Metabolic, 




(R)-[CAS]



other



dexefaroxan
1H-Imidazole, 2-(2-ethyl-2,3-dihydro-2-
89197-00-2
EP
71368
Cognitive enhancer
Alzheimer's 



benzofuranyl)-4,5-dihydro-[CAS]
89197-32-0



disease


Dexetimide

21888-98-2






dexibuprofen
Benzeneacetic acid, Alpha-methyl-4-(2-
51146-56-6


Analgesic, NSAID
Pain, general



methylpropyl)-, (AlphaS)-[CAS]







dexketoprofen
Benzeneacetic acid, 3-benzoyl-Alpha-
22161-81-5


Anti-inflammatory
Inflammation, 



methyl-, (S)-[CAS]




general


dexloxiglumide
Pentanoic acid, 4-[(3,4-
119817-90-2
EP
0344184
GI inflammatory/
Irritable bowel 



dichlorobenzoyl)amino]-5-[(3-



bowel disorders
syndrome



methoxypropyl)pentylamino]-5-oxo-,








(R)-[CAS]







dexmedeto-
1H-Imidazole, 4-[1-(2,3-
113775-47-6
EP
187471
Hypnotic/Sedative
Anaesthesia


midine
dimethylphenyl)ethyl]-, (R)-[CAS]
86347-15-1






dexmethyl-
2-Piperidineacetic acid, Alpha-phenyl-,
19262-68-1


Psychostimulant
Attention deficit 


phenidate
methyl ester, (AlphaR,2R)-




disorder


Dexpanthenol

81-13-0






dexrazoxane
2,6-Piperazinedione, 4,4′-(1-methyl-1,2-
24584-09-6 
DE
1910283 
Radio/
Chemotherapy-



ethanediyl)bis-, (5)-[CAS]



chemoprotective
induced injury, 








general


Dextran-1
Dextran [CAS]
9004-54-0


Plasma substitute



Dextranomer

56087-11-7






Dextroam-

51-64-9






phetamine








dextro-
Morphinan, 3-methoxy-17-methyl-,
6700-34-1
U.S.
4,221,788
Formulation, oral, 
Cough, Emotional 


methorphan
(9Alpha,13Alpha,14Alpha)-,
125-71-3


other
lability


Dextro-

357-56-2






moramide








dextropro-
Benzeneethanol, Alpha-[2-
469-62-5


Formulation, modified-
Pain, general


poxyphene
(dimethylamino)-1-methylethyl]-Alpha-



release, other




phenyl-, propanoate (ester), [S-(R,S*)]-








[CAS]







Dezocine

53648-55-8






DF-1012
N-Tropyl 7-azaindol-3-ylcarboxamide
163220-65-3
WO
9504742
Respiratory
Respiratory disease, 








general


DFA-IV
di-D-fructofuranose 2,6′:6,2′

U.S.
5,700,832
Antianaemic
anaemia, aplastic



dianhydride







d-Fenchone

4695-62-9






D-

32449-92-6






Glucurono-








lactone








Diab II
Diab II
309956-85-2
U.S.
6,153,632
Antidiabetic
Diabetes, Type II


diacerein
2-Anthracenecarboxylic acid, 4,5-
13739-02-1
U.S.
4,244,968
Antiarthritic, other
Arthritis, 



bis(acetyloxy)-9,10-dihydro-9,10-dioxo-




rheumatioid



[CAS]







Diampromide

552-25-0






Diamthazole

136-96-9






Diathy-

5964-62-5






mosulfone








Diatrizoate

737-31-5 






diazepam
2H-1,4-Benzodiazepin-2-one, 7-chloro-
439-14-5


Formulation, 
Anxiety, epilepsy, 



1,3-dihydro-1-methyl-5-phenyl-[CAS]



transmucosal,
general







systemic



Diaziquone

57998-68-2






Diazoxide

364-98-7






dibekacin
D-Streptamine, O-3-amino-3-deoxy-
34493-98-6
GB
1349302
Aminoglycoside 
Infection, general



Alpha-D-glucopyranosyl-(1-6)-O-[2,6-
58580-55-5


antibiotic




diamino-2,3,4,6-tetradeoxy-Alpha-D-








erythro-hexopyranosyl-(1-4)1-2-deoxy-,








sulfate (salt)[CAS]







Dibenzepin

4498-32-2






Dibromo-

496-00-4






propamidine








Dibucaine

61-12-1






Dichloral-

480-30-8






phenazone








Dichlor-

473-34-7






amine T








Dichlorisone

7008-26-6






Dichloro-

1777-82-8






benzyl 








Alcohol








Dichlorophen

97-23-4






Dichloro-

536-29-8






phenarsine








Dichlorphen-

120-97-8






amide








diclofenac + 
Hyaluronic acid + benzeneacetic acid,



Formulation, 
Keratosis


HA
2-[(2,6-dichlorophenyl)amino]-[CAS]



transdermal, 








systemic



diclofenac
Benzeneacetic acid, 2-[(2,6-
15307-79-6


Formulation, modified-
Pain, general



dichlorophenyl)amino]-, [CAS]
15307-86-5


release, <=24 hr





15307-81-0






Dicloxacillin

3116-76-5






Dicumarol

66-76-2






Dicyclomine

77-19-0






didanosine
Inosine, 2′,3′-dideoxy-[CAS]
69655-05-6
U.S.
4,861,759
Antiviral, anti-HIV
Infection, 








HIV/AIDS


Dideoxy-

4097-22-7






adenosine








didox
Benzamide, N,3,4-trihydroxy-[CAS]
69839-83-4
U.S.
4,263,322
Anticancer, 
Cancer, general







antimetabolite



Dienestrol

84-17-3






dienogest
19-Norpregna-4,9-diene-21-nitrile, 17-
65928-58-7
GB
1524917
Menstruation disorders
Endometriosis



hydroxy-3-oxo-, (17Alpha)-[CAS]







dienogest +
19-Norpregna-4,9-diene-21-nitrile, 17-



Formulation, fixed-dose
Contraceptive, 


estradiol
hydroxy-3-oxo-,(17Alpha) + Estra-



combinations
female



1,3,5(10)-triene-3,17-diol(17β)







Diethadione

702-54-5






Diethazine

60-91-3






Diethylbromo-

511-70-6






acetamide








Diethyl-

90-89-1






carbamazine








diethyl-
1-Propanone, 2-(diethylamino)-1-
90-84-6


Formulation, modified-
Obesity


propion
phenyl-[CAS]



release, <=24 hr



Diethyl-

56-53-1






stilbestrol








Difemerine

80387-96-8






Difenamizole

20170-20-1






Difenoxin

28782-42-5






Difenpiramide

51484-40-3






diflomotecan
(5R)-5-Ethyl-9,10-difluoro-1,4,5,13-
220997-97-7


Anticancer, other
Cancer, general



tetrahydro-5-hydroxy-3H,15H-








oxepino[3′,4′:6,indolizino[1,2-








b]quinoline-3,15-dione







diflorasone
Pregna-1,4-diene-3,20-dione, 17,21-
33564-31-7
U.S.
3,980,778
Antipsoriasis




bis(acetyloxy)-6,9-difluoro-11-hydroxy-
2557-49-5







16-methyl-, (6Alpha,11β,16β)-[CAS]







Difloxacin

98106-17-3






Diflucortolone

2607-6-9






diflunisal
2′,4′-difluoro-4-hydroxy[1,1′-biphenyl]-3-
23674-86-4
GB
1175212
Analgesic, NSAID
Pain, post 



carboxylic acid
22494-42-4



operative


Difluprednate

23674-86-4






Digitalin

752-61-4






Digitoxin

71-63-6






digoxin
Card-20(22)-enolide, 3-[(O-2,6-dideoxy-
20830-75-5
U.S.
4,088,750
Formulation, oral, 
Heart failure



β-D-ribo-hexopyranosyl-(1-4)-O-2,6-



enteric-coated




dideoxy-β-D-ribo-hexopyranosyl-(1-4)-








2,6-dideoxy-β-D-ribo-








hexopyranosyl)oxy]-12,14-dihydroxy-,








(3β,5β,12β)-[CAS]







Dihexy-

561-77-3






verine








Dihydral-

484-23-1






azine








Dihydro-

125-28-0






codeine








Dihydro-

466-90-0






codeinone 








Enol








dihydroer-
Ergocryptine, dihydro-[CAS]
25447-66-9


Formulation, other
Depression, general


gocryptine








dihydroer-,
Ergotaman-3′,6′, 18-trione, 9,10-dihydro
511-12-6

6495535 
Formulation, 
Migraine


gotamine 
12′-hydroxy-2′-methyl-5′-



modified-release, 




(phenylmethyl)-,



other




(5′Alpha, 10Alpha)-[CAS]







Dihydro-

509-60-4






morphine








Dihydrostre-

128-46-1






ptomycin








Dihydrota-

67-96-9






chysterol








Dihydroxy-

13682-92-3






aluminum










539-68-4






Diisopromine

5966-41-6






Diisopropyl 

3254-66-8






Paraoxon








Diisapropyl-

660-27-5






amine








dilazep
Benzoic acid, 3,4,5-trimethoxy-,
35898-87-4
JP
51095086
Vasodilator, coronary




(tetrahydro-1H-1,4-diazepine-1,4(5H)-








diyl)di-3,1-propanediyt ester [CAS]







Dilevalol

75659-07-3






diloxanide
2-Furancarboxylic acid, 4-
3736-81-0


Amoebicide




[(dichloroacetyl)methylamino]phenyl
579-38-4







ester [CAS]







diltiazem
1,5-Benzothiazepin-4(5H)-one, 3-
33286-22-5
U.S.
4,721,619
Antianginal
Angina, 



(acetyloxy)-5-[2-(dimethylamino)ethyl]-
42399-41-7
U.S.
5,529,791

hypertension,



2,3-dihydro-2-(4-methoxyphenyl)-, (2S-

EP
322277

general



cis)-[CAS]







Dimecrotic 

7706-67-4






Acid








Dim efline

1165-48-6






Dimemorfan

36309-01-0






Dimenhydrinate

523-87-5






Dimenoxadol

509-78-4






Dimepheptanol

545-90-4






Dimercaprol

59-52-9






Dimetacrine

4757-55-5






Dimethadione

695-53-4






Dimethazan

519-30-2






Dimethindene

5636-83-9






Dimethisoquin

86-80-6






Dimethisterone

79-64-1






Dimethocaine

94-15-5






Dimethoxanate

477-93-0






Dimethyl 

67-68-5






Sulfoxide








Dimethyl-

524-84-5






thiambutene








Dimetofrine

22950-29-4






Dimorphol-

119-48-2






amine








dinoprostone
Prosta-5,13-dien-1-oic acid, 11,15-
363-24-6


Formulation, modified-
Labour, induction



dihydroxy-9-oxa-,



release, <=24 hr




(5Z, 11 Alpha, 13E, 155)-[CAS]







diosmectite
Smecta-[CAS]
110070-78-5
FR
2770778
Antidiarrhoeal
Diarrhoea, general


diosmin
4H-1-Benzopyran-4-one, 7-[[6-O-(6-
520-27-4
DE
2602314
Vasoprotect, systemic




deoxy-Alpha-L-mannopyranosyl)-.beta.-








D-glucopyranosyl]oxy]-5-hydroxy-2-(3-








hydroxy-4-methoxyphenyl)-. [CAS]







Dioxadrol

6495-46-1 






Dioxaphetyl

467-86-7






Dioxethednne

497-75-6






Dioxybenzone

131-53-3 






Diphemanil

62-97-5






Diphenadione

82-66-6






Diphencyprone

886-38-4






Diphenhydramine

58-73-1






Diphenidol

972-02-1 






Diphenoxylate

915-30-0






Diphenylpyraline

147-20-6






Diphetarsone

515-76-4






Diphtheria & 








Tetanus








Toxoids And 








A cellular








Pertussis 








Vaccine 








Adsorbed








Dipipanone

467-83-4






dipivefrin
Propanoic acid, 2,2-dimethyl-, 4-[1-
52365-63-6
U.S.
3,809,714
Antiglaucoma
Glaucoma



hydroxy-2-(methylamino)ethyl]-1,2-








phenylene ester, (+/−)-[CAS]







Dipyridamole

58-32-2






Dipyrocetyl

486-79-3






Dipyrone

5907-38-0






diquafosol
Uridine 5′-(pentahydrogen
211427-08-6


Ophthalmological
Dry eye 



tetraphosphate)-5′-ester with uridine,




syndrome



[CAS]







dirithromycin
Erythromycin, 9-deoxo-11-deoxy-9,11-
62013-04-1
DE
2515075
Macrolide antibiotic
Tonsillitis



[imino[2-(2-








methoxyethoxy)ethylidene]oxy]-,








[95(R)]-[CAS]







disodium 
Phosphonic acid, (3-amino-1-
57248-88-1
EP
177443
Osteoporosis treatment
Hypercalcaemia 


pamidronate
hydroxypropylidene)bis-, disodium salt




of malignancy



[CAS]







Disofenin

65717-97-7 






disopyramide
2-Pyridineacetamide, Alpha-[2-[bis(1-
3737-09-5


Formulation, modified-
Arrythmia, general



methylethyl)amino]ethyl]-Alpha-phenyl- 



release, <=24 hr




[CAS]







Dastigmine

15876-67-2






Disulfamide

671-88-5






Disulfiram

97-77-8






Ditazol

18471-20-0






Dithiazanine

514-73-8






dithranol
9(10H)-Anthracenone, 1,8-dihydroxy-
1143-38-0


Formulation, dermal, 
Psoriasis



[CAS]



topical



Ditiocarb

148-18-5






Dixanthogen

502-55-6






Dixyrazine

2470-73-7.






DJ-927


WO
01027115
Anticancer, other
Cancer, general


DK-507k
(−)-7-[(75)-7-Amino-5-








azaspiro[2,4]heptan-5-yl]-6-fluoro-1-



Quinolone antibacterial
Infection, general



[(1R,2S)-2-fluoro-1-cyclopropyl]-1 .4-








dihydro-8-methoxy-4-oxo-3-








quinolinecarboxylic acid hydrochloride








monohydrate







DL-Lactic 

598-82-3






Acid








DMDC
Cytidine, 2′-deoxy-2′-methylene-,
113648-25-2
WO
8807049
Anticancer, 
Cancer, general



monohydrochloride [CAS]



antimetabolite



DMXAA
5,6-dimethylxanthenone-4-acetic acid



Anticancer, other
Cancer, lung, general


DNA Stealth 


U.S.
6,132,776
Antiviral, anti-HIV
Infection, HIV/AIDS


Nucleosides








Dobesilate

20123-80-2






dobutamine
1,2-Benzenediol, 4-[2-[[3-(4-
34368-04-2
U.S.
3,987,200
Cardiostimulant




hydroxyphenyl)-1-
49745-95-1







methylpropyl]amino]ethyl]-, (+/−)-[CAS]







Docarpamine

74639-40-0






docetaxel
(2R,3S)-N-Carboxy-3-phenylisoserine,
114977-28-5
EP
253738
Anticancer, other
Cancer, breast



N-tert-butyl ester, 13-ester with 5β,20-
148408-66-6







epoxy-1,2Alpha,4,7β, 10β, 13Alpha-








hexahydroxytax-11-en-9-one 4-acetate








2-benzoate-[CAS]







docosahexae-


EP
707487
Hypolipaemic/
Hyperlipidaemia, 


noic acid




Antiatherosclerosis
general


docosanol
1-Docosanol [CAS]
661-19-8
EP
469064
Antiviral, other
Infection, herpes 








simplex virus


docusate

128-49-4
U.S.
4,752,617
Formulation, derm
Infection, herpes 




577-11-7



simplex virus 








prophylaxis


dofetilide
Methanesulfonamide, N-[4-[2-[methyl[2-
115256-11-6
EP
245997
Antiarrhythmic
Fibrillation, atrial



[4-








[(methylsulfonyl)amino]phenoxy]ethyl]








amino]ethyl]phenyq-[CAS]







dolasetron 
1H-lndole-3-carboxylic acid, octahydro-
115956-13-3
EP
266730
Antiemetic
Chemotherapy-


mesilate
3-oxo-2,6-methano-2H-quinolizin-8-yl
115956-12-2 



induced nausea 



ester, (2Alpha,6Alpha,8Alpha,9Alphaβ)-,




and vomiting



monomethanesulfonate-[CAS]







Domiodoi

61869-07-6






Domiphen

538-71-6






Domitroban

112966-96-8






domperidone
2H-Benzimidazol-2-one, 5-chloro-1-[1-
57808-66-9
U.S.
4,066,772
Antiemetic




[3-(2,3-dihydro-2-oxo-1H-benzimidazol-








1-yl)propyl]-4-piperidinyl]-1,3-dihydro-








[CAS]







donepezil
1H-Inden-1-one, 2,3-dihydro-5,6-
120011-70-3
EP
296560
Cognition enhance
Alzheimer's disease



dimethoxy-2-((1-(phenylmethyl)-4-
120014-06-4







piperidinyl)methyl)-, [CAS]







donitriptan
Piperazine, 1-(((3-(2-aminoethyl)-1H-
170912-52-4


Antimigraine
Migraine



indol-5-yl)oxy)acetyl)-4-(4-








cyanophenyl)-[CAS]







Dopamine

51-61-6






Dopexamine

86197-47-9






doramapimod
urea, N-[3-(1,1-dimethylethyl)-1-(4-
285983-48-4


Antiarthritic, 
Arthritis, 



methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-



immunological
rheumatoid



(4-morpholinyl)ethoxy]-1-napthalenyl]







doranidazole
(±)-1,2,4-Butanetriol, 3-((2-nitro-1H-
137339-64-1
WO
9414778
Radio/chemosensitizer
Surgery adjunct



imidazol-1-yl)methoxy)-[CAS]







doripenem
(1R,5S,6S)-2-[(3S,5S)-5-
148016-81-3
EP
528678
Beta-lactam antibiotic
Infection, urinary 



(sulfamoylaminomethyl)pyrrolidin-3-




tract



yl]thio-6-[(1R)-1-hydroxyethyl]-1-








methylcarbapen-2-em-3-carboxylic








acid







darzolamide
4H-Thieno(2,3-b)thiopyran-2-
120279-96-1
EP
296879
Antiglaucoma
Glaucoma



sulfonamide, 4-(ethylamino)-5,6-








dihydro-6-methyl-,7,7-dioxide (4S-








trans)-[CAS]







dorzolamide + 
4H-Thieno(2,3-b)thiopyran-2-
120279-96-1


Formulation, fixed-dose
Glaucoma


timolol
sulfonamide, 4-(ethylamino)-5,6-
26839-75-8


combinations




dihydro-6-methyl-7,7-dioxide (45-trans) +
26921-17-5







ethyl 2-propanol, 1-[(1,1-








dimethyl)amino]-3-[[4-(4-morpholinyl)-








1,2,5-thiadiazol-3-yl]oxy]-, (5), (Z)-2-








butenedioate (1:1) (salt) [CAS]







dosmalfate
Aluminium, (μ7-(7-((6-O-(6-deoxy-2,3,4-
122312-55-4


Antiulcer
Ulcer, gastric



tri-O-sulfo-Alpha-L-mannosylpyranosyl)-








2,3,4-tri-O-sulfo-β-D-








glucopyranosyl)oxy)-5-hydroxy-2-(4-








methoxy-3-(sulfooxy)phenyl-4H-1-








benzopyran-4-onato(7-)))tetradeca-μ-








hydroxyheneicosahydroxytetradeca-








[CAS]







dosulepine
1-Propanamine, 3-dibenzo[b,e]thiepin-
113-53-1


Antidepressant




11(6H)-ylidene-N,N-dimethyl-[CAS]







Dotarizine

84625-59-2






Dothiepin

113-53-1






Doxacurium

106819-53-8






Doxapram

309-29-5






doxazosin
Piperazine, 1-(4-amino-6,7-dimethoxy-
74191-85-8
GB
2007656
Antihypertensive, 
Hypertension, 



2-quinazolinyl)-4-[(2,3-dihydro-1 4-



adrenergic
general



benzodioxin-2-yl)carbonyl]-[CAS]







Doxefazepam

40762-15-0






Doxenitoin

3254-93-1






doxepin
1-Propanamine, 3-dibenz[b,e]oxepin-
1668-19-5


Formulation, dermal, 
Pruritus



11(6H)-ylidene-N,N-dimethyl-



topical



doxercalciferol
9,10-secoergosta-5,7,10(19),22-
54573-75-0
U.S.
5,104,854
Hormone
Hyperpara-



tetraene-1,3-diol (1Alpha, 3β, 5Z, 7E,




thyroidism



22E) [CAS]







doxifluridine
Uridine, 5′-deoxy-5-fluoro-[CAS]
3094-09-5 
U.S.
4,071,680
Anticancer, 
Cancer, colorectal







antimetabolite



doxofylline
1H-Purine-2,6-dione, 7-(1,3-dioxolan-2-
69975-86-6
U.S.
4,187,308
Antiasthma
Asthma



ylmethyl)-3,7-dihydro-1,3-dimethyl-








[CAS]







doxorubicin
5,12-Naphthacenedione, 10-[(3-amino-
23214-92-8
EP
191824
Formulation, optimized, 
Cancer, general



2,3,6-trideoxy-Alpha-L-Iyxo-



liposomes




hexopyranosyl)oxy]-7,8,9,10-tetrahydro








6,8,11-trihydroxy-8-(hydroxyacetyl)-1-








methoxy-, (8S-cis)-[CAS]







doxycycline
2-Naphthacenecarboxamine, 4-
564-25-0


Formulation, modified-
Periodontitis



(dimethylamino)-1,4,4a,5,5a,6,11,12a-
17086-28-1


release, immediate




octahydro-3,5,10,12,12a-pentahydroxy-








6-methyl-1,11-dioxo-[4S-








(4Alpha,4aAlpha,5Alpha,5aAlpha,6Alpha,








12aAlpha)]-[CAS]







doxylamine
N,N-Dimethyl-2-[1-phenyl-1-(2-
469-21-6


Formulation, 
Rhinitis, allergic, 



pyridinyl)ethoxy]ethanamine



transmucosal
general







systemic



DPC-817
β-D-2′,3′-didehydro-2′,3′-dideoxy-5-



Antiviral, anti-HIV
Infection, HIV/AIDS



fluorocytidine







DPI-3290


U.S.
5,681,830
Analgesic, other
Pain, general


DQ-113
5-Amino-7-[(3S,4R)-(1-



Quinolone antibacterial
Infection, general



aminocyclopropyl)-3-fluoropyrrolidin-1-








yl]-1-[(1R,2S)-2-fluoro-1-cyclopropyl]-








1,4-dihydro-8-methyl-4-oxo-3-








quinolinecarboxylic acid







Drofenine

1679-76-1






Droloxifene

82413-20-5






Drometrizole

2440-22-4






Dromo-

58-19-5






stanolone








dronabinol
6H-Dibenzo[b,d]pyran-1-ol, 6a,7,8,10a-
1972-08-3


Antiemetic
Chemotherapy-



tetrahydro-6,6,9-trimethyl-3-pentyl-,




induced nausea 



(6aR-trans)-[CAS]




and vomiting


dronedarone
2-n-Butyl 3-[4-(3-di-n-butylamino-



Antiarrhythmic
Arrhythmia, 



propoxy)benzoyl]5-




general



methylsulfonamidobenzofuran







Droperidol

548-73-2






Droprenilamine

57653-27-7






Dropropizine

17692-31-8






Drospirenone

67392-87-4






Drotaverine

14009-24-6






Drotebanol

03/02/3176






droxicam
2H,5H-1,3-Oxazino[5,6-
90101-16-9
EP
99770
Anti-inflammatory
Inflammation, 



c][1,2]benzothiazine-2,4(3H)-dione, 5-




general



methyl-3-(2-pyridinyl)-, 6,6-dioxide








[CAS]







droxidopa
L-Tyrosine, β,3-dihydroxy-, threo-
23651-95-8
EP
128684
Antiparkinsonian
Parkinson's disease



[CAS]







Droxidopa

23651-95-8






DU-125530
1,2-Benzisothiazol-3(2H)-one, 2-[4-[4-
161611-99-0
EP
633260
Anxiolytic
Anxiety, general



(7-chloro-2,3-dihydro-1,4-benzodioxin-








5-yl)-1-piperazinyl]butyl]-, 1,1-dioxide








[CAS]







duloxetine
2-Thiophenepropanamine, N-methyl-
136434-34-9
U.S.
5,362,886
Antidepressant
Depression, general



Gamma-(1-naphthalenyloxy)-,
116539-59-4







hydrochloride, (S)-[CAS]







duramycin


WO 
9428726
Formulation, inhalable, 
Cystic fibrosis


Durapatite

1306-06-5


solution



dutasteride
4-Azaandrost-1-ene-17-carboxamide,
164656-23-9
U.S.
5,565,467
Prostate disoders
Benign prostatic 



N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-,




hyperplasia



(5Alpha,17β)-[CAS]







DW-1141
N,N-diisopropyl-4-[4-(3-



Osteoporosis treatment
Osteoporosis



aminobenzo[d]isoxazol-6-yloxy)butoxy]-








3-methoxybenzamide







DW-286a
(R)-(−)-7-((4-aminomethyl-4-methyl-3-



Quinolone antibacterial
Infection, general



(Z)-methyloxyimino)pyrrolidin-1-yl)-1-








cyclopropyl-6-fluoro-4-oxo-1,4-








dihydro[1,8]naphthyridine-3-carboxylic








acid







DW-471


U.S.
5,922,871
Antiviral, other
Infection, 








hepatitis-B virus


DX-9065a
2-Naphthalenepropanoic acid, 7-
155204-81-2


Antithrombotic
Thrombosis



(aminoiminomethyl)-Alpha-[4-[[1-(1-








iminoethyl)-3-pyrrolidinyl]oxy]phenyl]-,








monohydrochloride, pentahydrate, (S-








(R*,R*)]-[CAS]







DY-9760e
1H-Indazole, 3-[2-[4-(3-chloro-2-
160522-00-9
U.S.
5,681,954
Neuroprotective
Ischaemia, cerebral



methylphenyl)-1-piperazinyl]ethyl]-1-








(1H-imidazol-4-ylmethyl)-5,6-dimethoxy








[CAS]







Dyclonine

586-60-7






Dydrogesterone

152-62-5






Dymanthine

124-28-7






Dyphylline

479-18-5






E-1010
1-Azabicyclo[3.2.0]hept-2-ene-2-
186319-97-1


Beta-lactam antibiotic
Infection, general



cerboxylic acid, 6-[(1R)-1-hydroxyethyl]-








3-[((3S,5S)-5-[(R)-hydroxy(3R)-3-








pyrrolidinylmethyl]-3-pyrrolidinyl]thio]-








4-methyl-7-oxo-, monohydrochionde,








(4R,5S,6S)-[CAS]







E-2101
N-Ethyl-(1-[1-(2-



Muscle relaxant
Muscle spasm, 



fluorophenethyl)pipendin-4-yl]-1H-indol-




general



6-yl)acetamide







E2F antagonists


WO
9606943
Anticancer, other
Cancer, general


E-3620
Benzamide, 4-amino-5-chloro-N-(8-
151213-86-4
EP
554794
Antacid/Antiflatulent
Dyspepsia



methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-








[(1-methyl-2-butynyl)oxy]-,








monohydrochloride, [3(S)-endo]-. [CAS]







E-5564
Alpha-D-Glucopyranose, 3-O-decyl-2-
185954-98-7
EP
536969
Septic shock 
Sepsis



deoxy-6-O-(2-deoxy-3-O-((3R)-3-



treatment




methoxydecyl)-6-O-methyl-2-(((11Z)-1-








oxo-11-octadecenyl)amino)-4-O-








phosphono-β-D-glucopyranosyl)-2-








((1,3-dioxotetradecyl)amino)-1-








(dihydrogen phosphate), tetrasodium








salt [CAS]







E-5842
Pyridine, 4-(4-fluorophenyl)-1.2,3,6-
220120-14-9


Neuroleptic
Schizophrenia



tetrahydro-1-[4-(1H-1,2,4-triazol-1-








yl)butyl]-, 2-hydroxy-1,2,3-








propanetncarboxylate (1:1) [CAS]







E-6259
1-(4-Aminosulfonylphenyl)-5-(2,4-



Antiarthritic, other
Unspecified



difluorophenyl)-4,5-dihydro-3-








trifluoromethyl-1-H-pyrazole







EAA-90
[2-(8,9-Dioxo-2,6-



Analgesic, other
Pain, neuropathic



diazabicyclo[5.2.0]non-1 (7)-en-2-yl)-








ethyl]phosphonic acid







e-

57-08-9






Acetamido-








caproic 








Acid








e-Aminocaproic 

60-32-2






Acid








ebastine
1-Butanone, 1-[4-(1,1-
90729-43-4
EP
134124
Antiallergic, non-
Rhinitis, allergic, 



dimethylethyl)phenyl]-4-[4-



asthma
seasonal



(diphenylmethoxy)-1-piperidinyl]-[CAS]







eberconazole
1H-Imidazole, 1-(2,4-dichloro-10,11-
128326-82-9
ES
2012297 
Antifungal
Infection, 



dihydro-5H-dibenzo[a,d]cyclohepten-5-
130104-32-4



dermatological



yl)-[CAS]







ebrotidine
Benzenesulfonamide, N-[[[2-[[[2-
100981-43-9
EP
159012
Antiulcer
Ulcer, duodenal



[(aminoiminomethyl)amino]-4-








thiazoly]methyl]thio]ethyl]amino]methyl








ene]-4-bromo-[CAS]







ebselen
1,2-Benzisoselenazol-3(2H)-one, 2-
60940-34-3
EP
44971
Neuroprotective
Haemorrhage, 



phenyl-[CAS]




subarachnoid


Eburnamonine

474-00-0






Ecabapide

104775-36-2






ecabet
1-Phenanthrenecarboxylic acid,
33159-27-2
DE
3239172
Antiulcer
Ulcer, gastric



1,2,3,4,4a,9,10,10a-octahydro-1,4a-
86408-72-2







dimethyl-7-(1-methylethyl)-6-sulfo-, [1R-








(1Alpha,4aβ,10aAlpha)]-[CAS]







ecadotril
Glycine, N-[2-[(acetylthio)methyl]-1-oxo-
112573-73-6
EP
318377
Antihypertensive, 
Hypertension, 



3-phenylpropyl]-,phenylmethyl ester,



other
general



(S)-[CAS]







Ecgonidine

484-93-5






Ecgonine

481-37-8






Echothiophate

513-10-0






Econazole

27220-47-9






ecopipam
5H-Benzo[d]naphth[2,1-b]azepin-12-ol,
112108-01-7
EP
230270
Anorectic/Antiobesity
Obesity



11-chloro-6,6a,7,8,9,13b-hexahydro-7-








methyl-, (6aS-trans)-[CAS]







ecraprost
Prosta-8,13-dien-1-oic acid, 11,15-
136892-64-3
EP 
423697
Vasodilator, peripheral
Peripheral vascular 



dihydroxy-9-(1-oxobutoxy)-, butyl ester,




disease



(11Alpha,13E,15S)-[CAS]







Ectylurea

95-04-5






ED-71
9,10-Secocholesta-5,7,10(19)-triene-
104121-92-8
EP
184206
Osteoporosis treatment
Osteoporosis



1,3,25-triol, 2-(3-hydroxypropoxy)-,








(1Alpha,2β,3β,5Z,7E)-[CAS]







edaravone
3H-Pyrazol-3-one, 2,4-dihydro-5-
89-25-8
JP
62108814
Neuroprotective
Infarction, cerebral



methyl-2-phenyl-[CAS]







Edatrexate

80576-83-6 






Edetate Galcium 

62-33-9






Disodium








Edetate 

139-33-3






Disodium








Edetate 

64-02-8






Sodium








Edetate 

150-38-9






Trisodium








edonentan
Butanamide,N-[[2′-[[4,5-dimethyl-3-
210891-04-6


Cardiostimulant
Heart failure



isoxazoyl)amino]sulfonyl]-4-(2-








oxazolyl)[1,1′-biphenyl]-2-yl]methyl]-








N,3,3-trimethyl-, monohydrate







edotreotide
[N-[2-[4,7-Bis[(carboxy-kappaO)methyl]
204318-14-9
U.S.
6,183,721
Anticancer, hormonal
Cancer, lung, small 



10-(carboxymethyl)-1,4,7,10-




cell



tetraazacyclododec-1-yl-








kappaN1,kappaN4,kappaN10]acetyl]-D-








phenylalanyl-L-cysteinyl-L-tyrosyl-D-








tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-








L-threoninol cyclic (2-7)-disulfidato(3-)]








yttrium







edoxudine
Uridine, 2′-deaxy-5-ethyl-[CAS]
15176-29-1
GB
1170565
Antiviral, other
Infection, herpes 








virus, general


Edrecolomab

156586-89-9






Edrophonium

116-38-1






Efalith
Butanedioic acid, lithium salt [CAS]
16090-09-8


Antipruritic/inflamm, 
Eczema, 







allergic
seborrhoeic


efaproxiral
Propanoic acid, 2-[4-[2-[(3,5-
131179-95-8
U.S.
5,705,521
Radio/chemosensitizer
Cancer, brain



dimethylphenyl)amino]-2-








oxoethyl]phenoxy]-2-methyl-[CAS]







efavirenz
2H-3,1-Benzoxazin-2-one, 6-chloro-4-
154598-52-4
WO
9403440
Antiviral, anti-HIV
Infection, 



(cyclopropylethynyl)-1,4-dihydro-4-




HIV/AIDS



(trifluoromethyl)-, (S)-[CAS]







efletirizine
[2-[4-[Bis(p-fluorophenyl)methyl]-1-
150756-35-7
GB
2311940
Antiallergic, non-
Allergy, general



piperazinyllethoxylacetic acid



asthma



eflornithine
DL-Ornithine, 2-(difluoromethyl)-[CAS]
70052-12-9
U.S.
4,413,141
Protozoacide, dermal, 
Infection, 




67037-37-0


topical
trypanosomiasis,








African, Hirsutism


Efloxate

119-41-5






eflucimibe
Benzeneacetamide, Alpha-
202340-45-2


Hypolipaemic/
Hyperlipidaemia, 



(dodecylthio)-N-(4-hydroxy-2,3,5-



Antitherosclerosis
general



trimethylphenyl)- (S)-[CAS]







efonidipine
3-pyridinecarboxylic acid, 5-(5,5-
111011-53-1
EP
230944
Antihypertensive, 
Hypertension, 



dimethyl-1,3,2-dioxaphosphorinan-2-yl)
111011-63-3


other
general



1,4-dihydro-2,6-dimethyl-4-(3-
111011-76-8







nitrophenyl)-, 2-








(phenyl(phenylmethyl)amino)ethyl








ester, P-oxide [CAS]







EGIS-7229
5-Chloro-4-[3-[N-(2-(3,4-
150800-12-7
DE
4243381
Antiarrhythmic
Arrhythmia, 



dimethoxyphenyl)ethyl]-N-
190333-92-7



general



methylaminolpropylamino]- 3(2H)-








pyridazinone fumarate [CAS]







eglumegad
Bicyclo[3.1.0]hexane-2,6-dicarboxylic
176199-48-7


Anxiolytic
Anxiety, general



acid, 2-amino-, (1S,2S,5R,6S)-[CAS]
209216-09-1






egualen
1-Azulenesulfonic acid, 3-ethyl-7-(1-
97683-31-3
EP
147915
Antiulcer
Ulcer, gastric



methylethyl)-,
99287-30-6






Eicosa-

10417-94-4






pentaenoic 








Acid








elarofiban
3-Pyridinepropanoic acid, β-[((3R)-1-[1-
198958-88-2
WO
9741102
Antithrombotic
Thrombosis, 



oxo-3-(4-piperidinyl)propyl]-3-




general



piperidinyl]carbonyl]amino]-, (βS)-








[CAS]







Elcatonin

60731-46-6






Eledoisin

69-25-0






eletriptan
1H-Indole, 3-((1-methyl-2-
143322-58-1
U.S.
5,607,951
Antimigraine
Migraine



pyrrolidinyl)methyl)-5-(2-








(phenylsulfonyl)ethyl)- (R)-[CAS]







Elgodipine

119413-55-7






Ellagic Acid

476-66-4






Elliptinium

58337-35-2






Eltoprazine

98224-03-4






elvucitabine
β-L-2′,3′-Didehydro-2,3′-dideoxy-5-
181785-84-2


Antiviral, other
Infection, 



fluorocytidine




hepatitis-B virus


elzasonan
(2Z)-4-(3,4-dichlorophenyl)-2-[2-(4-
220322-05-4


Antidepressant
Depression, general



methylpiperazin-1-
361343-20-6







yl)benzylidene]thiomorpholin-3-one








monohydrochloride-[CAS]







Embelin

550-24-3






Embramine

3565-72-8






emedastine
1H-Benzimidazole, 1-(2-ethoxyethyl)-2-
87233-61-2
EP
79545
Antiallergic, non-
Rhinitis, allergic, 



(hexahydro-4-methyl-1H-1,4-diazepin-1-
87233-62-3


asthma
general



yl)-, (E)-2-butenedioate (1:2) [CAS]







Emepronium

3614-30-0






Emetine

483-18-1






Emitefur

110690-43-2






EMM-
17Alpha-Acetoxy-6Alpha-methyl-1 9-nor



Formulation, fixed-
Hormone 


210525
1β,2β-dihydrocyclopropa[1,2′]pregn-4-



dose combinations
replacement therapy



ene-3,20-dione+Estra-1,3,5(10)-triene-








3,17-diol(17β)







Emodin

518-82-1






emorfazone
3(2H)-Pyridazinone, 4-ethoxy-2-methyl-
38957-41-4
JP
7224030
Anti-inflammatory




5-(4-morpholinyl)-[CAS]







EMR-62203


WO 
9806722
Male sexual 
Impotence







dysfunction



emtricitabine
2(1H)-Pyrimidinone, 4-amino-5-fluoro-1
143491-57-0
WO
9214743
Antiviral, anti-HIV
Infection, HIV/AIDS



(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,








(2R-cis)-[CAS]







Emylcamate

78-28-4






enalapril
L-Proline, 1-[N-[1-(ethoxycarbonyl)-3-
76095-16-4
U.S.
4,374,829
Antihypertensive, renin 




phenylpropyl]-L-alanyl]-, (S)-, (Z)-2-



systetm




butenedioate [CAS]







Enalaprilat

76420-72-9






Enallyl-

1861-21-8






propymal








Encainide

66778-36-7






Enciprazine

68576-86-3






End ralazine

39715-02-1






enfenamic acid
Benzoic acid, 2-[(2-phenylethyl)amino]-
23049-93-6
IN
103066
Anti-inflammatory




[CAS]







enflurane
Ethane, 2-chloro-1-(difluoromethoxy)-
13838-16-9
U.S.
3,469,011
Anaesthetic, inhalation
Anaesthesia



1,1,2-trifluoro-[CAS]







Enilconazole

35554-44-0






Eniluracil

59989-18-3






ENMD-0995
S-3-amino-phthalidoglutarimide

U.S.
5,712,291
Anticancer, other
Cancer, myeloma


Enocitabine

55726-47-1






Enol-3-IPA
1H-Indole-3-propanoic acid, Alpha-oxo-
392-12-1
EP
106813
Hypnotic/Sedative
Insomnia



[CAS]







enoxacin
1,8-Naphthyridine-3-carboxylic acid, 1-
74011-58-8
U.S.
4,359,578
Quinolone antibacter
Infection, general



ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-








piperazinyl)-[CAS]







enoxaparin
Heparin, [CAS]
9005-49-6
EP
40144
Antithrombotic
Thrombosis, venous




9041-08-1






enoximone
2H-Imidazol-2-one, 1,3-dihydro-4-
77671-31-9
EP
59948
Cardiostimulant
Heart failure



methyl-5-[4-(methylthio)benzoyl]-








[CAS]







Enoxolone

471-53-4






enprostil
4,5-Heptadienoic acid, 7-[3-hydroxy-2-
73121-56-9
GB
2025431
Prostaglandin
Ulcer, duodenal



(3-hydroxy-4-phenoxy-1-butenyl)-5-








oxocyclopentyl]-, methyl ester,








[1Alpha,2β(1E,3R*),3Alpha]-[CAS]







enrasentan
1H-Indene-2-carboxylic acid, 1-(1,3-
167256-08-8
U.S.
5,817,693
Antihypertensive, 
Hypertension, 



benzodioxol-5-yl)-2,3-dihydro-3-(2-(2-



other
pulmonary



hydroxyethoxy)-4-methoxyphenyl)-5-








propoxy-, (1S-(lAlpha,2β,3Alpha))-








[CAS]







entacapone
2-Propenamide, 2-cyano-3-(4,5-
130929-57-6
EP
426468
Antiparkinsonian
Parkinson's disease



dihydroxy-3-nitrophenyl)-N,N-diethyl-








[CAS]







entecavir
6H-Purin-6-one, 2-amino-1,9-dihydro-9
142217-69-4 
EP
481754
Antiviral, other
Infection, 



((1S,3R,4S)-4-hydroxy-3-




hepatitis-B virus



(hydroxymethyl)-2-








methylenecyclopentyl]-[CAS]







Enviomycin

33103-22-9






epalrestat
3-Thiazolidineacetic acid, 5-(2-methyl-3
82159-09-9
EP
47109
Symptomatic 
Neuropathy, diabetic



phenyl-2-propenylidene)-4-oxo-2-thioxo-,



antidiabetic




(E,E)-[CAS]







Epavir
L-lysine-cis-5,8,11,14,17-



Antiviral, other
Infection, herpes 



eicosapentanoate with L-lysine-cis-




simplex virus



4,7,10,13,16,19-doahexanoate







EPC-K1
L-ascorbic acid 2-[3,4-dihydro-2,5,7,8-
127061-56-7
EP
127471
Neuroprotective
Infarction, cerebral



tetramethyl-2-(4,8,12-trimethyltridecyl)-








2H-1-benzopyran-6-yl-hydrogen








phosphate]potassium-[CAS]







eperisone
1-Propanone, 1-(4-ethylphenyl)-2-
64840-90-0 
U.S.
3,995,047
Muscle relaxant
Spastic paralysis



methyl-3-(1-pipendinyl)-[CAS]







epervudine
Uridine, 2′-deoxy-5-(1-methylethyl)-
60136-25-6
DE
2918260
Antiviral, other
Infection, herpes 



[CAS]




simplex virus


Ephedrine

299-42-3






Epiclilin

26774-90-3






Epimestrol

7004-98-0






epinastine
1H-Dibenz[c,f]imidazo[1,5-a]azepin-3-
80012-43-7
DE
3008944
Antiasthma
Asthma



amine, 9,13b-dihydro-[CAS]







epinephrine
(R)-4-[1-hydroxy-2-(methylamino)-
51-43-4


Formulation, inhalable, 
Anaphylaxis



ethyl]-1,2-benzenediol



dry powder



Epinzole

18694-40-1






epirubicin
5,1 2-Naphthacenedione, 1 0-[(3-amino-
56390-09-1
GB
1457632
Anticancer, antibiotic




2,3,6-trideoxy-Alpha-L-arabino-
56420-45-2







hexopyranosyl)oxy]-7,8,9,10-tetrahydro








6,8,11-trihydroxy-8-(hydroxyacetyl)-1-








methoxy-, (8S-cis)-[CAS]







Epitiostanol
2363-58-8







eplerenone
Pregn-4-ene-7,21-dicarboxylic acid,
107724-20-9
EP
122232
Antihypertensive, 
Hypertension, general



9,11-epoxy-17-hydroxy-3-oxo-,Gamma



diuretic




lactone, methyl ester








(7Alpha,11Alpha,17Alpha)-[CAS]







eplivanserin
1-Propanone,1-(2-fluorophenyl)-3-(4-
130580-02-8
EP
373998
Anxiolytic
Schizophrenia



hydroxyphenyl)-, O-(2-








(dimethylamino)ethyl)oxime, (Z)-, (E)-2-








butenedloate (2:1) (salt) [CAS]







epoprostenol
Prosta-5,13-dien-1-oic acid, 6,9-epoxy-
35121-78-9
DE
2720999
Prostaglandin
Hypertension, 



11,15-dihydroxy-,
61849-14-7



pulmonary



(5Z,9Alpha,11Alpha,13E,15S)-[CAS]







Epostane

80471-63-2






Eprazinone

10402-90-1






Epristeride

119169-78-7






eprosartan
3-[2-Butyl-1-(4-carboxybenzyl)-1H-
133040-01-4
EP
403159
Antihypertensive, renin 
Hypertension, general



imidazol-5-yl]-2-(2-thienylmethyl)-2-(E)-



system




propenoic acid







Eprozinol

32665-36-4






eptapirone
4-methyl-2-[4-(4-(pyrimidin-2-yl)-
179756-85-5


Antidepressant
Depression, general



piperazino)-butyl]-2H,4H-1,2,4-triazin-








3,5-dione







eptaplatin
Platinum, [(4R,5R)-2-(1-methylethyl)-
146665-77-2
WO
9216539
Anticancer, alkylating.
Cancer, lung, small 



1,3-dioxolane-4,5-dimethanamine-




cell



kappaN4′,kappaN5][propanedioato(2-)-








kappaO1,kappaO3]-, (SP-4-2)-[CAS]







Eptastigmine
101246-68-8







eptazocine
1,6-Methano-1H-4-benzazonin-10-ol,
72522-13-5
U.S.
4,082,744
Analgesic, other




2,3,4,5,6,7-hexahydro-1,4-dimethyl-,








(1S)-[CAS]







Eptifibatide

188627-80-7






Equilenin

517-09-9






Equilin

474-86-2






ERA-923
ERA 923 [CAS]
352233-89-7
EP
802183
Female 
Contraceptive, 







contraceptive
female


erdosteine
Acetic acid, [[2-oxo-2-[(tetrahydro-2-
84611-23-4
EP
61386
Respiratory
Respiratory disease, 



oxo-3-thienyl)amino]ethyl]thio]-[CAS]




general


Ergocornine

564-36-3






Ergocorninine

564-37-4






Ergoloid 

8067-24-1






Mesylates








Ergonovine

60-79-7






Ergosterol

57-87-4






ergotamine
(5′Alpha)-12′-Hydroxy-2′methyl-
113-15-5


Formulation, 
Migraine



(phenylmethyl)ergotaman-3′,6′, 18-



inhhalable, systemic




trione







Eritadenine

23918-98-1






erlotinib
4-Quinazolinamine, N-(3-
183319-69-9
WO 
9630347 
Anticancer, other
Cancer, lung, 



ethynylphenyl)-6,7-bis(2-




non-small cell



methoxyethoxy)-, monohydrochloride








[CAS]







ertapenem
1-Azabicyclo[3.2.0]hept-2-ene-2-
153773-82-1
WO
9315078 
Beta-lactam antibiotic
Infection, GI tract



carboxylic acid, 3-[[(3S,5S)-5-[[(3-
153832-46-3 







carboxyphenyl)amino]carbonyl]-3-








pyrrolidinyl]thio]-6-[(1R)-1-








hydroxyethyl]-4-methyl-7-oxo-, 








[CAS]







Erythrityl 

7297-25-8






Tetranitrate








Erythro-

50276-98-7






centaurin








erythromycin 
Erythromycin, 2′-acetate,
96128-89-1
U.S.
4,599,326
Macrolide antibiotic
Infection, general


acistrate
octadecanoate (salt) [CAS]







Erythromycin 

3521-62-8






Estolate








Erythromycin 

23067-13-2






Glucoheptonate








Erythromycin 

3847-29-8 






Lactobionate








Erythromycin 

134-36-1






Propionate








Erythromycin 

643-22-1






Stearate








erythromycin 
Erythromycin, 2′-propanoate, compd.
84252-03-9
EP
57489 
Macrolide antibiotic
Infection, respiratory 


stinoprate
with N-acetyl-L-cysteine (1:1) [CAS]




tract, lower


erythromycin
Erythromycin [CAS]
114-07-8


Formulation, dermal, 
Acne


Erythrophleine

36150-73-9


topical



Esaprazole

64204-55-3






escitalopram
5-Isobenzofurancarbonitrile, 1-[3-
128196-01-0
EP
347066
Antidepressant
Depression, general



(dimethylamino)propyl]-1-(4-








fluorophenyl)-1,3-dihydro-, (5)-[CAS]







Esculin

531-75-9






Eseridine

25573-43-7






esmolol
Benzenepropanoic acid, 4-[2-hydroxy-3-
81147-92-4
US 
4,387,103
Antihypertensive, 
Tachycardia,



[(1-methylethyl)amino]propoxy]-,



adrenergic
supraventricular



methyl ester, (+/−)-[CAS]







esomeprazole
bis (5-methoxy-2-(((4-methoxy-3,5-
161 973-10-0 
US 
5,877,192
Antispasmodic
Gastro-oesophageal 



dimethyl-2-pyridinyl)methyl)sulflnyl)-1H-




reflux



benzimidazolato)







estazolam
4H-[1,2,4]Triazolo[4,3-
29975-16-4
US 
3,987,052
Hypnotic/Sedative




a][1,4]benzodiazepine, 8-chloro-6-








phenyl-[CAS]







estradiol
Androst-4-en-3-one, 17-hydroxy-, (17β)
58-22-0
U.S.
5,460,820
Formulation, transdermal, 
Sexual dysfunction, 



[CAS]



patch
female


estradiol
Estra-1,3,5(10)-triene-3,17-diol (17β)-
50-28-2
EP
430491
Formulation, transdermal, 
Menopausal 



[CAS]



systemic
symptoms, general


estramustine
Estra-1,3,5(10)-triene-3,17-diol (17β)-,
2998-57-4


Anticancer, alkylating
Cancer, prostate



3-[bis(2-chloroethyl)carbamate] 17-
4891-15-0







[CAS]
52205-73-9






Estnol

50-27-1






estrogen


WO
9924041
Menopausal disorders
Menopausal 








symptoms, general


Estrone

53-16-7






eszopiclone
1-Piperazinecarboxylic acid, 4-methyl-
138729-47-2
U.S.
5,786,357
Hypnotic/Sedative
Insomnia



6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-








oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester








(S)-[CAS]







Etafednne

7681-79-0






Etafenone

90-54-0






Etamiphyllin

314-35-2






Etanercept

185243-69-0






Etanidazole

22668-01-5






Etaqualone

7432-25-9 






Eterobarb

27511-99-5






Ethacridine

442-16-0






Ethacrynic 

58-54-8






Acid








Ethadione

520-77-4






Ethambutol

74-55-5






Ethamivan

304-84-7






Ethamsylate

2624-44-4






Ethanolamine

141-43-5






Ethaverine

486-47-5 






Ethchlorvynol

113-18-8






Ethenzamide

938-73-8






Ethiazide

1824-58-4






Ethinamate

126-52-3






Ethinyl 

57-63-6






Estradiol








ethinyl 
19-Norpregna-1,3,5(10)-trien-20-yne-
28913-23-7
DE
1949095
Formulation, modified-
Cancer, prostate


estradiol
3,17-diol, 3-(2-propanesulfonate),



release, >24 hr




(17Alpha)-[CAS]







Ethionamide

536-33-4






Ethisterone

434-03-7






Ethoheptazine

77-15-6






Ethopropazine

522-00-9






Ethosuximide

77-67-8






Ethotoin

86-35-1






Ethoxzolamide

452-35-7






Ethybenztropine

524-83-4






Ethyl Alcohol

64-17-5






Ethyl 

548-00-5






Biscoumacetate








Ethyl Chloride

75-00-3






Ethyl Dibunate

5560-69-0 






Ethyl Ether

60-29-7






ethyl 
5,8,11,14,17-Eicosapentaenoic acid,
86227-47-6
JP
61043143
Antithrombotic
Peripheral vascular 


icosapentate
ethyl ester, (all-Z)-[CAS]




disease


ethyl 
1H-1,4-Benzodiazepine-3-carboxylic
29177-84-2
U.S.
3,657,223 
Anxiolytic
Anxiety, general


loflazepate
acid, 7-chloro-5-(2-fluorophenyl)-2,3-








dihydro-2-oxo-, ethyl ester [CAS]







Ethyl 

29177-84-2






Loflazepate








Ethylamine

75-04-7






Ethylene

74-85-1






Ethylestrenol

965-90-2






Ethylidene 

1821-16-5






Dicoumarol








Ethylmethyl-

441-61-2






thiambutene








Ethylmorphine

76-58-4






Ethylnore-

536-24-3






pinephrine








Ethynodiol

1231-93-2






ethynylcytidine
Uridine, 3′-C-ethynyl-[CAS]
180300-49-6
WO
9618636
Anticancer, 
Cancer, general







antimetabolite



Etidocaine

36637-18-0






etidronate
Phosphonic acid, (1-
2809-21-4
U.S.
4,137,309
Osteoporosis 
Osteoporosis



hydroxyethylidene)bis-, [CAS]
7414-83-7


treatment



Etidronic Acid

2809-21-4






Etifelmin

341-00-4






etifoxine
4H-3,1-Benzoxazin-2-amine, 6-chloro-
21715-46-8
U.S.
3,725,404
Anxiolytic




N-ethyl-4-methyl-4-phenyl-[CAS]







Etilefnn

709-55-7






etilevodopa
L-Tyrosine, 3-hydroxy-, ethyl ester
37178-37-3
U.S.
5,354,885
Antiparkinsonian
Parkinson's 



[CAS]




disease


etiprednol
androsta-1,4-diene-17-carboxylic acid,
199331-40-3


GI inflammatory/
Crohn's disease



17-[(dichloroacetyl)oxy]-11-hydroxy-3-



bowel disorders




oxo-, ethyl ester, (11β,17Alpha)-







Etiroxate

17365-01-4 






Etizolam

40054-69-1






etodolac
Pyrano[3,4-b]indole-1-acetic acid, 1,8-
41340-25-4
U.S.
3,939,178
Antiarthritic, other
Arthritis, osteo



diethyl-1,3,4,9-tetrahydro-[CAS]







Etodroxizine

17692-34-1






etofenamate
Benzoic acid, 2-[[3-
30544-47-9
GB
1285400
Anti-inflammatory, 
Inflammation, 



(trifluoromethyl)phenyl]amino]-, 2-(2-



topical
general



hydroxyethoxy)ethyl ester [CAS]







etofibrate
3-Pyridinecarboxylic acid, 2-[2-(4-
31637-97-5 
U.S.
3,723,446
Hypolipaemic/




chlorophenoxy)-2-methyl-1-



Antiatherosclerosis




oxopropoxylethyl ester [CAS]







Etofylline

519-37-9






etofylline 
Propanoic acid, 2-(4-chlorophenoxy)-2-
54504-70-0
DE
2308826
Hypolipaemic/



clofibrate
methyl-, 2-(1,2,3,6-tetrahydro-1,3-



Antiatherosclerosis




dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl








ester [CAS]







Etofylline 

13425-39-3






Nicotinate








Etog lucid

1954-28-5






Etomid ate

33125-97-2






Etomidoline

21590-92-1






Etonitazene

911-65-9






etonogestrel
18,19-Dinorpregn-4-en-20-yn-3-one,
54048-10-1


Formulation, implant
Contraceptive, 



13-ethyl-17-hydroxy-11-methylene,




female



(17Alpha)-[CAS]







Etoperidone

52942-31-1






etoposide
Furo[3′,4′:6,7]naphtho[2,3-d]-l,3-dioxol-
33419-42-0
GB
1205966
Anticancer, other
Cancer, testicular



6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-








glucopyranosyl)oxy]-5,8,8a,9-








tetrahydro-5-(4-hydroxy-3,5-








dimethoxyphenyl)-, [5R-








[5Alpha,5aβ,8aAlpha,9β(R*)]]-[CAS]







etoposide 
Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-
117091-64-2
EP
302473
Anticancer, other
Cancer, testicular


phosphate
6(5aH)-one, 5-[3,5-dimethoxy-4-








(phosphonooxy)phenyl]-9-[(4,6-0-








ethylidene-β-D-glucopyranosyl)oxy]-








5,8,8a,9-tetrahydro-, [5R-








[5Alpha,5aβ,8aAlpha,9β(R*)]]-[CAS]







etoricoxib
2,3-Bipyridine, 5-chloro-6′-methyl-3-(4-
202409-33-4
WO
9803484
Antiarthritic, other
Arthritis, osteo



(methylsulfonyl)phenyl) [CAS]







Etoxadrol

28189-85-7






Etozolin

73-09-6






etretinate
2,4,6,8-Nonatetraenoic acid, 9-(4-
54350-48-0
U.S.
4,215,215
Antipsoriasis




methoxy-2,3,6-trimethylphenyl)-3,7-








dimethyl-, ethyl ester, (all-E)-[CAS]







Etryptamine

2235-90-7






Etymemazine

523-54-6






Eucatropine

100-91-4






Eugenol

97-53-0






EUK-134
Manganese, chloro[[2,2′-[1,2-
81065-76-1
U.S.
6,046,188
Cardiovascular
Unspecified



ethanediylbis[(nitrilo-








kappaN)methylidyne]]bis(6-








methoxyphenolato-kappaO]]]-, (SP-5-








13)-[CAS]







EUK-189


U.S.
6,046,188
Radio/
Chemotherapy-







chemoprotective
induced injury, 








general


Evan's Blue

314-13-6






everolimus
Rapamycin, 42-O-(2-hydroxyethyl)-
159351-69-6
WO
9409010
Immunosuppressant
Transplant rejection, 



[CAS]




general


exalamide
Benzamide, 2-(hexyloxy)-[CAS]
53370-90-4
GB
726786
Antifungal
Infection, fungal, 








general


Exametazime

105613-48-7






exatecan
10H,13H-
171335-80-1


Anticancer, other
Cancer, pancreatic



Benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-








b]quinoline-10,13-diane, 1-amino-9-








ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-








9-hydroxy-4-methyl-, (1S,9S)-, [CAS]







exemestane
Androsta-1,4-diene-3,17-diane, 6-
107868-30-4
DE
3622841
Anticancer, hormonal
Cancer, breast



methylene-[CAS]







Exifone

52479-85-3






exisulind
1H-Indene-3-acetic acid 5-fluora-2-
59973-80-7


Anticancer, other
Polyp



methyl-1-((4-








(methylsulfonyl)phenyl)methylene)-, (Z)-








[CAS]







Exosurf

99732-49-7






ezetimibe
2-Azetidinone, 1-(4-fluorophenyl)-3-
163222-33-1
U.S.
5,846,966
Hypolipaemic/
Hypercholesterol-



[(35)-3-(4-fluorophenyl)-3-



Antiantherosclerosis
aemia



hydroxypropyl]-4-(4-hydroxyphenyl)-,








(3R,45)-[CAS]







Factor IX

9001-28-9






Factor VIII

9001-27-8






Factor XIII

9013-56-3






fadolmidine
1H-Inden-5-ol, 2,3-dihydro-3-(1H-
189353-32-0
WO
9712874
Analgesic, other
Pain, general



imidazol-4-ylmethyl)-,








monohydrochloride [CAS]







Fadrozole

102676-47-1






falecalcitriol
9,10-Secocholesta-5,7,10(19)-triene-
83805-11-2
JP
03099022
Osteoporosis treatment
Hyperparathyroidism



1,3,25-triol, 26,26,26,27,27,27-








hexafluoro-, (1Alpha,3β,5Z,7E)-[CAS]







famciclovir
1,3-Propanediol, 2-[2-(2-amino-9H-
104227-87-4
JP
61085388
Antiviral, other
Infection, 



purin-9-yl)ethyl]-, diacetate (ester)-




gynaecological



[CAS]







famotidine
Propanimidamide, 3-[[[2-
76824-35-6
U.S.
4,283,408
Antiulcer
Ulcer, duodenal



[(aminoiminomethyl)amino]-4-








thiazolyl]methyl]thio]-N-(aminosulfonyl)-








[CAS]







fampridine
4-pyridinamine
504-24-5


Neuroprotective
Spinal cord injury


fandofloxacin
3-Quinolinecarboxylic acid, 6-fluoro-1-
164150-85-0
U.S.
5,496,947
Quinolone 
Infection, urinary 



(5-fluoro-2-pyridinyl)-1,4-dihydro-7-(4-
164150-99-6


antibacterial
tract



methyl-1-piperazinyl)-4-oxo, [CAS]







Fantofarone

114432-13-2






faropenem 
(5R,6S)-6-[1(R)-Hydroxyethyl]-2-[2(R)-



Beta-lactam antibiotic
Infection, general


daloxate
tetrahydrofuryl]-2-penem-3-carboxylic








acid-5-methyl-2-oxo-1,3-dioxol-4-








ylmethyl ester







faropenem
4-Thia-1-azabicycio[3.2.0]hept-2-ene-2-
122547-49-3
EP
410727
Beta-lactam antibiotic
Infection, ocular



carboxylic acid, 6-(1-hydroxyethyl)-7-








oxo-3-(tetrahydro-2-furanyl)-, [5R-








[3(R*),5Alpha,6Alpha(R*)]]-[CAS]







fasidotril
L-Alanine, N-[(2S)-3-(acetylthio)-2-(1,3-
135038-57-2
EP
419327
Antihypertensive, renin 
Hypertension, general



benzodioxol-5-ylmethyl)-1-oxopropyl]-,



system




phenylmethyl ester [CAS]







fasudil
1H-1,4-Diazepine, hexahydro-1-(5-
103745-39-7
EP
187371
Neuroprotective
Vasospasm, general



isoquinolinylsulfonyl)-[CAS]
105628-07-7






Fazadinium 

49564-56-9






Bromide








febarbamate
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-[2-
13246-02-1
U.S.
3,075,983
Psychostimulant




[(aminocarbonyl)oxy]-3-butoxypropyl]-5








ethyl-5-phenyl-[CAS]







Febuprol

3102-00-9






febuxostat
5-Thiazolecarboxylic acid, 2-[3-cyano-4
144060-53-7
WO
9209279
Antigout
Hyperuricaemia



(2-methylpropoxy)phenyl]-4-methyl-








[CAS]







Fedotozine

123618-00-8






felbamate
1 .3-Propanediol, 2-phenyl-,
25451-15-4
U.S.
4,868,327
Antiepileptic
Epilepsy, general



dicarbamate [CAS]







felbinac
[1,1′-Biphenyl]-4-acetic acid [CAS]
5728-52-9
EP
127840
Anti-inflammatory, 








topical



felodipine
3,5-Pyridinedicarboxylic acid, 4-(2,3-
72509-76-3
U.S.
4,264,611
Antihypertensive, 
Hypertension, 



dichlorophenyl)-1,4-dihydro-2,6-



other
general



dimethyl-, ethyl methyl ester [CAS]







Felypressin

56-59-7






Femoxetine

59859-58-4






Fenbenicillin

1926-48-3 






fenbufen
[1,1-Biphenyl]-4-butanoic acid,
36330-85-5
U.S.
3,784,701
Anti-inflammatory




Gamma-oxo-[CAS]







Fenbutrazate

4378-36-3






Fencamfamine

1209-98-9






Fencamine

28947-50-4






Fenclozic Acid

17969-20-9






Fendiline

13042-18-7






Fendosal

53597-27-6






Fenethylline

3736081






Fenfluramine

458-24-2






Fenipentol

583-03-9 






fenofibrate
Propanoic acid, 2-[4-(4-
26129-32-8


Formulation, modified-
Hyperlididaemia, 



chlorobenzoyl)phenoxy]-2-methyl-, 1-
49562-28-9


release <=24 hr
general



methylethyl ester [CAS]







fenoldopam
1H-3-Benzazepine-7,8-diol, 6-chloro-
67227-56-9
EP
22330
Antihypertensive, 
Hypertension, 



2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-
67227-57-0


other
general



[CAS]







Fenoprofen

31879-05-7






Fenoterol

13392-18-2






fenoverine
10H-Phenothiazine, 10-[[4-(1,3-
37561-27-6
FR
2092639
Antispasmodic




benzodioxol-5-ylmethyl)-1-








piperazinyl]acetyl]-[CAS]







Fenoxazoline

4846-91-7






Fenoxedil

54063-40-0






Fenozolone

15302-16-6






Fenpentadiol

15687-18-0






Fenpiprane

3540-95-2






Fenpiverinium 

125-60-0






Bromide








Fenproporex

15686-61-0






Fenquizone

20287-37-0






fenretinide
Retinamide, N-(4-hydroxyphenyl)-
65646-68-6
BE
847942
Anticancer, other
Cancer, breast



[CAS]







Fenspiride

5053066






fentanyl
Propanamide, N-phenyl-N-[1-(2-
437-38-7


Formulation, 
Anaesthesia, adjunct



phenylethyl)-4-piperidinyl]-[CAS]



transmucosal,








systemic



Fentiazac

18046-21-4






Fenticlor

97-24-5






fenticonazole
1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-
72479-26-6
U.S.
4,221,803
Antifungal
Infection, 



2-[[4-(phenylthio)phenyl]methoxy]ethyl]-
73151-29-8



gynaecological



[CAS]







Fentonium 

5868064






Bromide








fepradinol
Benzenemethanol, Alpha-[[(2-hydroxy-
36981-91-6


Anti-inflammatory, 




1,1-dimethylethyl)amino]methyl]-, (+/−)-
67704-50-1


topical




[CAS]
63075-47-8






Feprazone

30748-29-9






Ferric Sodium 

15708-41-5






Edetate








ferrioxamine B


WO
9426263 
Septic shock 
Respitory distress







treatment
syndrome, adult


Ferrocholinate

1336-80-7 






Ferrous 

299-29-6






Giuconate








ferumoxytol
Polyglucose sorbitol carboxymethyl



Imaging agent
Diagnosis, cancer



ether-coated non-stoichiometric








magnetite








Imaging agent







fesoterodine
2-((1R)-3-(bis(1-methylethyl)amino)-1-
286930-03-8


Urological
Incontinence



phenylpropyl)-4-(hydroxymethyl)Phenyl








ester, (2E)-2-butenedioate (1:1) (Salt) -








[CAS]







fexofenadine
Benzeneacetic acid, 4-[1-hydroxy-4-
153439-40-8
U.S.
5,375,693 
Antiallergic, non-
Rhinitis, allergic, 



[4(hydroxydiphenylmethyl)-1-
83799-24-0


asthma
seasonal



pipendinyl]butyl]-Alpha,Alpha-dimethyl-,
138452-21-8







[CAS]







Fibrostat


CA
2132416
Vulnerary
Wound healing


fidarestat
Spiro(4H-1-benzopyran-4,4-
136087-85-9
EP
418834
Symptomatic 
Neuropathy, 



imidazolidine)-2-carboxamide, 6-fluoro-



antidiabetic
diabetic



2,3-dihydro-2′,5′-dioxo-, (2S-cis)-,








[CAS]







fiduxosin
8-Phenyl-3-[4-[(3aR,9bR)-1,3a,4,9b-
208993-54-8


Prostate disorders
Benign prostatic 



tetrahydro-9-




hyperplasia



methoxy[1]benzopyrano[3,4-c]pyrrol-








2(3H)-








yl]butyl]pyrazino[2′,3′:4,5]thieno[3,2-








d]pyrimidine-2,4(1H,3H)-dione







finasteride
4-Azaandrost-1-ene-17-carboxamide,
98319-26-7 
EP
155096
Prostate disorders
Benign prostatic 



N-(1,1-dimethylethyl)-3-oxo-,




hyperplasia



(5Alpha,17β)-[CAS]







finrozole
Benzonitrile, 4-(3-(4-fluorophenyl)-2-
160146-16-7
EP
476944
Urological
Urinary retention



hydroxy-1-(1H-1,2,4-triazol-1-yl)-propyl)








[CAS]







Fipexide

34161-24-5






FK-960
N-(4-Acetyl-1-piperazinyl)-4-
133920-70-4
WO 
9101979 
Cognition enhancer
Alzheimer's disease



fluorobenzamide monohydrate-[CAS]







Flavopiridol

146426-40-6






flavoxate
4H-1-Benzopyran-8-carboxylic acid, 3-
15301-69-6
U.S.
2,921,070
Urological




methyl-4-oxo-2-phenyl-, 2-(1-
3717-88-2







piperidinyl)ethyl ester [CAS]







flecainide
Benzamide,N-(2-piperidinylmethyl)-2,5-
54143-55-4


Formulation, modified-
Fibrillation, atrial



bis(2,2,2-trifluoroethoxy)-,[CAS]
54143-56-5


release <=24 hr



fleroxacin
3-Quinolinecarboxylic acid, 6,8-difluoro-
79660-53-0
U.S.
4,398,029
Quinolone 
Infection, general



1-(2-fluoroethyl)-1,4-dihydro-7-(4-
79660-72-3


antibacterial




methyl-1-piperazinyl)-4-oxo-[CAS]







Flesinoxan

98206-10-1






flibanserin
2H-Benzimidazol-2-one, 1,3-dihydro-1-
167933-07-5


Reproductive/gonadal, 
Sexual dysfunction, 



(2-(4-(3-(trifluoromethyl)phenyl)-1-



general
female



piperazinyl)ethyl)-[CAS]







floctafenine
Benzoic acid, 2-[[8-(trifluoromethyl)-4-
23779-99-9
U.S.
3,644,368
Analgesic, NSAID




quinoiinyl]amino]-, 2,3-dihydroxypropyl








ester [CAS]







flomoxef
5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-
92823-03-5
EP
128536
Cephalosporin, 
Infection, general



carboxylic acid, 7-
99665-00-6


injectable




[[[(difluoromethyl)thio]acetyl]amino]-3-








[[[1-(2-hydroxyethyl)-1H-tetrazol-5-








yl]thio]methyl]-7-methoxy-8-oxo-, (6R-








cis)-[CAS]







Flopropione

2295-58-1 






Florantyrone

519-95-9






Flosequinan

76568-02-0






Floxacillin

5250-39-5 






Floxuridine

50-91-9






Fluacizine

30223-48-4






Fluanisone

1480-19-9 






fluasterone
Androst-5-en-17-one, 16-fluoro-,
112859-71-9
EP
246650
Cardiovascular
Keratosis



(16Alpha)-[CAS]







fluazacort
5′H-Pregna-1,4-dieno[17,16-d]oxazole-
19888-56-3
U.S.
3,461,119
Antipruritic/inflamm, 




3,20-dione, 21-(acetyloxy)-9-fluoro-11-



non-allergic




hydroxy-2′-methyl-, (11β,16β)-[CAS]







Flucloronide

3693-39-8






flucloxacillin

1847-24-1


Formulation, other
Infection, general




34214-51-2






fluconazole
1H-1,2,4-Triazole-1-ethanol, Alpha-(2,4-
86386-73-4
EP
96569
Antifungal
Infection, 



difluorophenyl)-Alpha-(1H-1,2,4-triazol-




dermatological



1-ylmethyl)-[CAS]







Flucytosine

2022-85-7






fludarabine
9H-Purin-6-amine, 2-fluoro-9-(5-O-
75607-67-9
U.S.
4,357,324
Anticancer, 
Cancer, leukaemia, 



phosphono-β-D-arabinofuranosyl)-
21679-14-1


antimetabolite
chronic 



[CAS]




lymphocytic


Fludeoxy-

105851-17-0






glucose F1B








Fludiazepam

3900-31-0






Fludrocortisone

127-31-1






Flufenamic 

530-78-9






Acid








Fluindione

957-56-2






flumazenil
4H-Imidazo[1,5-a][1,4]benzodiazepine-
78755-81-4
EP
27214
Neurological




3-carboxylic acid, 8-fluoro-5,6-dihydro-








5-methyl-6-oxo-, ethyl ester [CAS]







Flumecinol

56430-99-0






Flumequine

42835-25-6






Flumethasone

2 135-17-3






Flumethiazide

148-56-1






flunarizine
Piperazine, 1-[bis(4-
30484-77-6
GB
1268710
Antimigraine




fluorophenyl)methyl]-4-(3-phenyl-2-
52468-60-7







propenyl)-,(E)-[CAS]
27848-84-6






flunisolide
Pregna-1,4-diene-3,20-dione, 6-fluoro-
3385-03-3 
U.S.
3,124,571
Antiasthma
Rhinitis, allergic, 



11,21-dihydroxy-16,17-[(1-




general



methylethylidene)bis(oxy)]-,








(6Alpha,11β,16Alpha)-[CAS]







flunitrazepam
2H-1,4-Benzodiazepin-2-one, 5-(2-
1622-62-4
U.S.
3,116,203
Hypnotic/Sedative




fluorophenyl)-1,3-dihydro-1-methyl-7-








nitro-[CAS]







Flunoxaprofen

66934-18-7






Fluocinolone 

67-73-2






Acetonide








Fluocinonide

356-12-7






Fluocortin 

41767-29-7






Butyl








Fluocortolone

152-97-6






Fluorescein

2321-07-5






Fluoresone

2924-67-6






Fluoro-

426-13-1






metholone








Fluorosalan

4776061






fluorouracil
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
51-21-8


Formulation, 
Keratosis



[CAS]



transdermal, enhanced



fluoxetine
Benzenepropanamine, N-methyl
54910-89-3
U.S.
4,314,081
Antidepressant
Depression, general



Gamma-[4-(trifluoromethyl)phenoxy]-,
56296-78-7







(+/−)-[CAS]







Fluoxymesterone

76-43-7






Flupentixol

2709-56-0






Fluperolone

2119-75-7






Fluphenazine

69-23-8






flupirtine
Carbamic acid, [2-amino-6-[[(4-
33400-45-2
U.S.
4,481,205
Analgesic, other
Pain, post-operative



fluorophenyl)methyl]amino]-3-
56995-20-1







pyridinyl]-, ethyl ester [CAS]
75507-68-5






Fluprednidene 

1255-35-2






Acetate








Fluprednisolone

53-34-9






Fluproquazone

40507-23-1






Flurandrenolide

1524-88-5






Flurazepam

17617-23-1






flurbiprofen
[1,1-Biphenyl]-4-acetic acid, 2-fluoro-
5104-49-4
U.S.
3,793,457
Anti-inflammatory




Alpha-methyl-[CAS]







flurithromycin
Erythromycin, 8-fluoro-mono(ethyl
82730-23-2
EP
56291
Macrolide antibiotic
Infection, respitory 



butanedioate) (ester)-[CAS]




tract, lower


Flurogestone

2529-45-5






Flurothyl

333-36-8






Fluroxene

406-90-6






Fluspirilene

1841-19-6






flutamide
Propanamide, 2-methyl-N-[4-nitro-3-
13311-84-7
U.S.
4,329,364
Anticancer, hormonal




(trifluoromethyl)phenyl]-[CAS]







flutazolam
Oxazolo[3,2-d][1,4]benzodiazepin-
27060-91-9
U.S.
3,905,956
Anxiolytic




6(SH)-one, 10-chloro-11b-(2-








fluorophenyl)-2,3,7,11b-tetrahydro-7-(2








hydroxyethyl)-[CAS]







fluticasone
Androsta-1,4-diene-17-carbothioic
80474-14-2


Formulation, inhalable, 
Asthma



acid, 6,9-difluoro-11,17-dihydroxy-16-
90566-53-3


solution




methyl-3-oxo-, S-(fluoromethyl) ester,








(6Alpha, 11β, 16Alpha, 17Alpha)-[CAS]







flutoprazepam
2H-1,4-Benzodiazepin-2-one, 7-chloro-
25967-29-7
GB
1253368
Anxiolytic
Psychosis, general



1-(cyclopropylmethyl)-5-(2-








fluorophenyl)-1,3-dihydro-[CAS]







flutrimazole
1H-Imidazole, 1-[(2-fluorophenyl)(4-
119006-77-8
EP
352352
Antifungal
Infection, 



fluorophenyl)phenylmethyl]-[CAS]




dermatological


Flutropium 

63516-07-4






Bromide








fluvastatin
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-
93957-55-2
EP
114027
Hypolipaemic/
Hypercholesterol-



1-(1-methylethyl)-1H-indol-2-yl]-3,5-
93957-54-1


Antiantherosclerosis
aemia



dihydroxy-, monosodium salt, [R*,S*-








(E)]-(±)-[CAS]







fluvoxamine
1-Pentanone, 5-methoxy-1-[4-
61718-82-9
GB
1535226
Antidepressant
Depression, general



(trifluoromethyl)phenyl]-O-(2-
54739-18-3



Obsessive-



aminoethyl)oxime, (E)-[CAS]




compulsive








disorder


Folic Acid

59-30-3






Folinic Acid

58-05-9






Fomepizole

7554-65-6






fominoben
Benzamide, N-[3-chloro-2-[[methyl[2-(4
18053-31-1
U.S.
3,661,903
Respiratory stimulant
Eczema, general



morpholinyl)-2-
24600-36-0







oxoethyl]amino]methyl]phenyl]-[CAS]







Fomivirsen

144245-52-3






Fomocaine

17692-39-6






Fonazine

7456-24-8 






fondaparinux
Alpha-D-Glucopyranoside, methyl 0-2-
104993-28-4


Anticoagulant
Thrombosis, venous



deoxy-6-O-sulfo-2-(sulfoamino)-Alpha-
114870-03-0







D-glucopyranosyl-(1-4)-O-β-D-








glucopyranuronosyl-(1-4)-O-2-deoxy-








3,6-di-O-sulfo-2-(sulfoamino)-Alpha-D-








glucopyranosyl-(1-4)-O-2-O-sulfo-








Alpha-L-idopyranuronosyl-(1-4)-2-








deoxy-2-(sulfoamino)-,6-(hydrogen








sulfate) [CAS]







Formebolone

2454117






formestane
Androst-4-ene-3, 17-dione, 4-hydroxy-
566-48-3
EP
346953
Anticancer, hormonal
Cancer, breast



[CAS]







Formocortal

2825-60-7






formoterol
Formamide, N-[2-hydroxy-5-[1-hydroxy
43229-80-7
GB
1415256 
Antiasthma
Asthma



2-[[2-(4-methoxyphenyl)-1-
73573-87-2







methylethyl]amino]ethyl]phenyl]-,








(R*,R*)-(+/−)-[CAS]







fosamprenavir
Carbamic acid, ((1S,2R)-3-(((4-
226700-81-8


Antiviral, anti-HIV
Infection, HIV/AIDS



aminophenyl)sulfonyl)(2-








methylpropyl)amino)-1-(phenylmethyl)-








2-(phosphonooxy)propyl)-C-((3S)-








tetrahydro-3-furanyl ester, [CAS]







foscarnet
Phosphinecarboxylic acid, dihydroxy-,
34156-56-4
U.S.
4,839,445
Antiviral, other
Infection, 



oxide, trisodium salt [CAS]
4428-95-9



cytomegalovirus




63585-09-1






Fosfestrol

522-40-7






fosfluconazole
2,4-difluoro-Alpha,Alpha-bis(1H-1,2,4-
194798-83-9


Antifungal
Infection, fungal, 



triazol-1-ylmethyl)benzyl alcohol,




general



dihydrogen phosphate (ester)







fosfomycin
Phosphonic acid, (3-methyloxiranyl)-,
23155-02-4
GB
1223923
Antibiotic, other
Infection, general



(2R-cis)-[CAS]
26016-98-8






fosfomycin 
Phosphonic acid, (3-methyloxiranyl)-,
78964-85-9 
EP
27597
Antibiotic, other
Infection, urinary 


trometamol
(2R-cis)-, compd. with 2-amino-2-




tract



(hydroxymethyl)-1,3-propanediol (1:1)-








[CAS]







Fosfosal

6064-83-1






fosinopril
L-Proline, 4-cyclohexyl-1-[[[2-methyl-1-
88889-14-9
EP
63896
Antihypertensive, renin 
Hypertension, 



(1-oxopropoxy)propoxy] (4-
98048-97-6


system
general



phenylbutyl)phosphinyl]acetyl]-,








(2Alpha,4β)-[CAS]







fosphenytoin
2,4-Imidazolidinedione, 5,5-diphenyl-3-
92134-98-0
U.S.
4,260,769
Antiepileptic
Epilepsy, 



[(phosphonooxy)methyl]-[CAS]
93390-81-9



generalized, tonic-








clonic


fotemustine
Phosphonic acid, [1-[[[(2-
92118-27-9
EP
117959
Anticancer, alkylating
Cancer, melanoma



chloroethyl)nitrosoamino]carbonyl]amino]








ethyl]-, diethyl ester [CAS]







Fropenem

106560-14-9






frovatriptan
1H-Carbazole-6-carboxamide, 2,3,4,9-
158747-02-5
WO
9922730
Antimigraine
Migraine



tetrahydro-3-(methylamino)-, (R)-








[CAS]







Fructose

57-48-7






Fructose-1,6-

488-69-7






diphosphate








FTC
2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-



Antiviral, anti-HIV
Infection, HIV/AIDS



(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-








(4R)







FTY-720
1,3-Propanediol, 2-amino-2-(2-(4-
162359-56-0
WO
9408943
Immunosuppressant
Transplant rejection, 



octylphenyl)ethyl)-,hydrochloride [CAS]




general


fudosteine
Alanine, 3-((3-hydroxypropyl)thio)-
13189-98-5
U.S.
5,047,428
Antitussive
Cough



[CAS]







fulvestrant
Estra-1,3,5(10)-triene-3,17-diol, 7-[9-
129453-61-8
EP
346014
Anticancer, hormonal
Cancer, breast



[(4,4,5,5,5-








pentafluoropentyl)sulflnyl]nonyl]-,








(7Alpha,17β)-[CAS]







fumagiline
2,4,6,8-Decatetraenedioic acid,
23110-15-8


Protozoacide
Infection, GI tract



mono[5-methoxy-4-[2-methyl-3-(3-








methyl-2-butenyl)oxiranyl]-1-








oxaspiro[2.5]oct-6-yl] ester, [3R-








(3Alpha,4Alpha(2R*,3R*),5β,6β(all-E)]]-








[CAS]







Fumagillin

23110-15-8 






Furaltadone

139-91-3 






Furazabol

1239-29-8 






Furazolidone

67-45-8 






Furazolium 

5118-17-2 






Chloride








Furonazide

3460-67-1 






furosemide
Benzoic acid, 5-(aminosulfonyl)-4-
54-31-9


Formulation, modified-
Hypertension, 



chloro-2-[(2-furanylmethyl)amino]-



release, other
general



[CAS]







Fursultiamine

804-30-8






Furtrethonium

7618-86-2






Fusidic Acid

06/03/6990






G1, YM 
1-(5-bromofur-2-yl)-2-bromo-2-



Antifungal
Infection, 


BioSciences
nitroethene




gynaecological


G25


WO
9804252
Antimalarial
Infection, malaria


GABA-A 


WO
0206285
Cognition enhancer
Alzheimer's disease


Alpha5 inverse








agonist,Mer








gabapentin
Cyclohexaneacetic acid, 1-
60142-96-3
U.S.
4,152,326
Antiepileptic
Epilepsy, general



(aminomethyl)-[CAS]







gabexate
Benzoic acid, 4-[[6-
39492-01-8
U.S.
3,751,447
GI inflammatory/bowel 
Pancreatitis



[(aminoiminomethyl)amino]-1-
56974-61-9 


disorders




oxohexyljoxy]-, ethyl ester,








monomethanesulfonate [CAS]







gaboxadol
Isoxazolo[5,4-c]pyridin-3(2H)-one,
64603-91-4
CA
1125288
Hypnotic/Sedative
Sleep disorder, 



4,5,6,7-tetrahydro-[CAS]




general


Gadobenate 

127000-20-8






Dimeglumine








Gadobutrol

138071-82-6






Gadodiamide

131410-48-5






Gadopentetic 

80529-93-7 






Acid








Gadoteridol

120066-54-8






Gadoversetamide

131069-91-5






Gadoxetic Acid

135326-11-3






galantamine
(4aS,6R,8aS)-6-Hydroxy-3-methoxy-11-



Formulation, modified-
Alzheimer's disease



methyl-5,6,9,10,11,12-hexahydro-4aH-



release, other




benzofuro[3a,3,2-e,f][2]benzazepine







Galanthamine

357-70-0 






galarubicin
β-Alanine, 2-[4-[(2,6-dideoxy-2-fluoro-
140637-82-7
EP
424899
Anticancer, antibiotic
Cancer, breast



Alpha-L-talopyranosyl)oxy]-1,2,3,4,6,11-
140637-86-1







hexahydro-2,5,12-trihydroxy-7-methoxy-








6,11-dioxo-2-naphthacenyl]-2-oxoethyl








ester, [CAS]







Gallamine 

65-29-2






Triethiodide








Gallic Acid

149-91-7






gallium 
4H-Pyran-4-one, 3-hydroxy-2-methyl-,



Anticancer, other
Cancer, myeloma


maltolate
gallium complex







gallium nitrate
Nitric acid, gallium salt [CAS]
13494-90-1
U.S.
4,529,593
Osteoporosh
Hypercalcaemia of








malignancy


gallopamil
Benzeneacetonitrile, Alpha-[3-[[2-(3,4-
16662-47-8
GB
1367677
Antianginal
Angina, general



dimethoxyphenyl)ethyl]methylamino]








propyl]-3,4,5-trimethoxy-Alpha-(1-








methylethyl)-[CAS]







g-Aminobutyric 

56-12-2






Acid








Ganaxolone

38398-32-2






ganciclovir
6H-Purin-6-one, 2-amino-1,9-dihydro-9
107910-75-8
EP
49072
Antiviral, other
Infection, 



[[2-hydroxy-1-
82410-32-0



cytomegalovirus



(hydroxymethyl)ethoxy]methyl]-[CAS]







ganirelix
[N-Ac-D-NaI,D-pCl-Phe,D-Pal,D-
124904-93-4
EP
312052
Releasing hormones
infertility, female



hArg(Et)2,hArg(Et)2,D-Ala]GnRH-








[CAS]







ganstigmine
Carbamic acid, (2-ethylphenyl)-,
223585-99-7 
EP
1023297
Cognition enhancer
Alzheimer's disease



(3aS,8aS)-1,2,3,3a,8,8a-hexahydro-








1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl








ester,







gantofiban
1-Piperazineacetic acid, 4-[[(5R)-3-[4-
183547-57-1
EP
741133
Antithrombotic
Thrombosis, general



[imino[(methoxycarbonyl)amino]methyl]








phenyl]-2-oxo-5-oxazolidinyl]methyl]-,








ethylester [CAS]







garenoxacin
3-Quinolinecarboxylic acid, 1-
223652-82-2


Quinolone antibacterial
Infection, respiratory 



cyclopropyl-8-(difluoromethoxy)-7-((1R)




tract, lower



2,3-dihydro-1-methyl-1H-isoindol-5-yl)-








1,4-dihydro-4-oxo-








monomethanesulfonate [CAS]







gamocestim
5-73-macrophage inflammatory protein
246861-96-1


Radio/chemoprotective
Chemotherapy-



2Alpha (human gene gro2)-[CAS]




induced injury, 








bonemarrow,








neutropenia


gatifloxacin
3-Quinolinecarboxylic acid, 1-
112811-59-3
EP
230295
Quinolone antibacterial
Infection, repiratory 



cyclopropyl-6-fluoro-1,4-dihydro-8-




tract, general



methoxy-7-(3-methyl-1-piperazinyl)-4-








oxo-, (+/−)-[CAS]







Gefarnate

51-77-4






gefitinib
4-Quinazolinamine, N-(3-chloro-4-
184475-35-2
WO
9633980
Anticancer, other
Cancer, lung, 



fluorophenyl)-7-methoxy-6-(3-(4-




non-small cell



morpholinyl)propoxy) [CAS]







gemcabene
6,6′-oxybis(2,2-dimethylhexanoate)
209789-08-2


Hypolipaemic/
Hyperlipidaemia, 







Antitherosclerosis
general


gemcitabine
Cytidine, 2′-deoxy-2′, 2′-difluoro-, [CAS]
122111-03-9
GB
2136425
Anticancer, 
Cancer, pancreatic




95058-81-4


antimetabolite



gemeprost
Prosta-2,13-dien-1-oic acid, 11,15-
64318-79-2
GB
1540427
Prostaglandin




dihydroxy-16,16-dimethyl-9-oxo-,








methyl ester, (2E,11Alpha,13E,15R)-








[CAS]







gemfibrozil
Pentanoic acid, 5-(2,5-
25812-30-0
U.S.
3,674,836
Hypolipaemic/
Hyperlipidaemia, 



dimethylphenoxy)-2,2-dimethyl-[CAS]



Antiatherosclerosis
general


gemifloxacin
1,8-Naphthyridine-3-carboxylic acid, 7-
175463-14-6
U.S.
5,869,670
Quinolone antibacterial
Infection, respitory 



(3-(aminomethyl)-4-(methoxyimino)-1-




tract, general



pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-








dihydro-4-oxo-[CAS]







gentamicin
Gentamicin [CAS]
1403-66-3


Formulation, implant
Infection, general


Gentian Violet

548-62-9






Gentiopicrin

20831-76-9






Gentisic Acid

490-79-9






Gepef rifle

18840-47-6






gepirone
2,6-Piperidinedione, 4,4-dimethyl-1-[4-



Formulation, modified-
Depression, general



[4-(2-pyrimidinyl)-1-piperazinyljbutyl]-



release, other




[CAS]







gestodene
18,19-Dinorpregna-4,15-dien-20-yn-3-
109852-02-0
GB
1569135
Formulation, fixed-dose
Contraceptive, 



one, 13-ethyl-17-hydroxy-, (17Alpha)-
60282-87-3


combinations
female



[CAS]







gestodene + 
18,19-Dinorpregna-4,15-dien-20-yn-3-



Formulation, modified-
Contraceptive, 


ethinylest
one, 13-ethyl-17-hydroxy-, (17Alpha)



release, >24 hr
female



mixt with 19-Norpregna-1,3,5(10)-trien-








20-yne-13,17-diol (17Alpha)







Gestonorone 

1253-28-7






Caproate








Gestrinone

16320-04-0






g-

591-81-1






Hydroxy-








butyrate








gimatecan
dimethylethoxy)imino]methyl]-4-ethyl-4-
292618-32-7


Anticancer, other
Cancer, brain



hydroxy-1-12-dihydro-14H-








pyrano[3,4′:6,7]indolizino[1,2-








b]quinoline-3,14(4H)-dione







Giractide

24870-04-0






Gitoxin

4562-36-1






GL-406349
N,N′-Bis[2-[N-[2-(N2,N5-dimethyl-DL-



Antifungal
Infection, fungal, 



Iysylamino)-ethyl]carbamoyl]1H-indol-6-




general



yl]-1H-indole-2,5-dicarboxamide







Glafenine

3820-67-5 






glatiramer
L-Glutamic acid, polymer with L-
147245-92-9
WO
5800808
Multiple sclerosis 
Multiple sclerosis, 



alanine, L-lysine and L-tyrosine, [CAS]
28704-27-0


treatment
relapsing-remitting


Glibornuride

26944-48-9






gliclazide
Benzenesulfonamide, N-
21187-98-4
GB
1153982
Antidiabetic
Diabetes, Type II



[[(hexahydrocyclopenta[c]pyrrol-2(1H)








yl)amino]carbonyl]-4-methyl-[CAS]







glimepiride
1H-Pyrrole-1-carboxamide, 3-ethyl-2,5-
93479-97-1
WO
9303724
Antidiabetic
Diabetes, Type II



dihydro-4-methyl-N-[2-[4-[[[[(4-








methylcyclohexyl)amino]carbonyl]








amino]sulfonyl]phenyl]ethyl]-2-oxo- 








[CAS]







g-Linolenic 

506-26-3 






Acid








glipizide
Pyrazinecarboxamide, N-[2-[4-
29094-61-9
U.S.
3,669,966
Antidiabetic




[[[(cyclohexylamino)carbonyl]amino]








sulfonyl]phenyl]ethyl]-5-methyl-[CAS]







gliquidone
Benzenesulfonamide, N-
33342-05-1
GB
1277847
Antidiabetic
Diabetes, general



[(cyclohexylamino)carbonyl]-4-[2-(3,4-








dihydro-7-methoxy-4,4-dimethyl-1,3-








dioxo-2(1H)-isoquinolinyl)ethyl]-[CAS]







glisolamide
3-Isoxazolecarboxamide, N-[2-[4-
24477-37-0


Antidiabetic
Diabetes, general



[[[(cyclohexylamino)carbonyl]amino]








sulfonyl]phenyl]ethyl]-5-methyl-[CAS]







Glisoxepid

25046-79-1






Glucametacin

52443-21-7






Glucoheptonic 

87-74-1






Acid








Gluconic Acid

526-95-4






glucosamine
D-Glucose, 2-amino-2-deoxy-, [CAS]
29031-19-4
DE
1953689
Antiarthritic, other
Arthritis, osteo




3416-24-8






Glucosulfone

554-18-7






glufosfamide
β-D-Glucopyranose, 1-(N,N′-bis(2-
132682-98-5
DE
3835772
Anticancer, alkylating
Cancer, general



chloroethyl)phosphorodiamidate)-








[CAS]







Glutamic Acid

56-86-0






Glutaraldehyde

111-30-8






Glutethimide

77-21-4






Giyburide

10238-21-8






Glybuthiazol(e)

535-65-9






Glybuzole

1492-02-0






Glycerol

56-81-5






Glycocyamine

352-97-6






Glycol Salicylate

87-28-5






Glyconiazide

3691-74-5






Glycopyrrolate

596-51-0






Glyhexamide

451-71-8






Glymidine

339-44-6






Glypinamide

1228-19-9






GMDP
N-acetylglucosaminyl-N-acetylmuramyl



Anti-infective,
Infection, general



dipeptide







Gold Sodium 

12244-57-4






Thiomalate








Gold Sodium 

10233-88-2






Thiosulfate








goserelin
Luteinizing hormone-releasing factor
65807-02-5
U.S.
4,100,274
Releasing hormones
Cancer, prostate



(pig), 6-[O-(1,1-dimethylethyl)-D-serine]








10-deglycinamide-, 2-








(aminocarbonyl)hydrazide [CAS]







GPI-1485
L-Proline, 1-(3,3-dimethyl-1,2-
186452-09-5


Antiparkinsonian
Parkinson's disease



dioxopentyl)-, 3-(3-pyridinyl)propyl








ester [CAS]







GPI-5693
2-(Phosphonomethyl)pentanedioic acid

U.S.
5,672,592
Anagesic, other
Pain, neuropathic


Graftskin








granisetron
1H-Indazole-3-carboxamide, 1-methyl-
107007-99-8
EP
200444
Antiemetic
Chemotherapy-



N-(9-methyl-9-azabicycio[3.3.1]non-3-
109889-09-0



induced nausea 



yl)-, endo-[CAS]




and vomiting


Grepafloxacin

119914-60-2






griseofuivin
Spiro[benzofuran-2(3H), 1′-
126-07-8


Formulation, dermal, 
Infection, 



[2]cyclohexane]-3,4-dione, 7-chloro-



topical
dermatological



2′,4,6-trimeth-oxy-6′methyl-, (1′S-trans)








[CAS]







Guaiacol

90-05-1






Guaiapate

852-42-6






Guaiazulene

489-84-9






Guaifenesin

93-14-1






guaimesal
4H-1,3-Benzodioxin-4-one, 2-(2-
81674-79-5
GB
2098201
Anti-inflammatory




methoxyphenoxy)-2-methyl-[CAS]







Guamecycline

16545-11-2






Guanabenz

5051-62-7






Guanadrel

40580-59-4






Guanethidine

55-65-2






Guanfacine

29110-47-2






Guanoxabenz

24047-25-4






Guanoxan

2165-19-7






gugulipid
Pregna-4,17(20)-diene-3,16-dione
95975-55-6
EP
447706
Hypolipaemic/




[CAS]



Antiantherosclerosis



Gusperimus

104317-84-2






GW-280430A
(Z)-2-Chlorofumaric acid 1-[3-[-[6,7-



Muscle relaxant
Anaesthesia, 



dimethoxy-2(S)-methyl-1 (R)-(3,4,5-




adjunct



trimethoxybenzyl)-1,2,3,4-








tetrahydroisoquinolinium-2-yl]propyl]







GW-320659
[2S,3S,5R]-2-[3,5-difluorophenyl]-3,5-



Anorectic/Antiobesity
Obesity



dimethyl-2-morpholinol







GYKI-16084
(+)-R-2-{3-[N-(2-

U.S.
6,194,411
Prostate disorders
Benign prostatic 



Benzo[1,4]dioxanylmethyl)amino]-1-




hyperplasia



propyl}-3(2H)-pyndazinone








hydrochloride







Hachimycin

1394-02-1 






Halazepam

23092-17-3






Halcinonide

3093-35-4






halobetasol
Pregna-1,4-diene-3,20-dione, 21-
66852-54-8
U.S.
4,619,921
Antipsoriasis
Psoriasis



chloro-6,9-difluoro-11-hydroxy-16-








methyl-17-(1-oxopropoxy)-,








(6Alpha,11β,16β)-[CAS]







halofantrine
9-Phenanthrenemethanol, 1,3-dichloro-
36167-63-2
EP
138374
Antimalarial
Infection, malaria



Alpha-[2-(dibutylamino)ethyl]-6-
69756-53-2







(trifluoromethyl)-[CAS]







halometasone
Pregna-1,4-diene-3,20-dione, 2-chloro-
50629-82-8
U.S.
4,076,737
Antipruritic/inflamm, 




6,9-difluoro-11,17,21-trihydroxy-16-



allergic




methyl-, (6Alpha,11β,16Alpha)-[CAS]







Haloperidol

52-86-8






Halopredone

57781-14-3






Haloprogin

777-11-7






Halopropane

679-84-5






Halothane

151-67-7






Haloxazolam

59128-97-1






harkoseride
2(R)-Acetamido-N-benzyl-3-

WO
9733861
Antiepileptic
Epilepsy, general



methoxypropionamide







HE-2000
16Alpha-Bromo-3β-hydroxy-5Alpha-



Antiviral, anti-HIV
Infection, HIV/AIDS



androstane-17-one







Healos


WO
9714376
Musculoskeletal
Regeneration, bone


Hemato-

14459-29-1






porphyrin








Hepronicate

7237-81-2






Heptabarbital

509-86-4






Heptaminol

372-66-7






Hetacillin

3511-16-8






Hetastarch

9004-62-0






Hexachlorophene

70-30-4






Hexadimethrine 

28728-55-4






Bromide








Hexafluorenium 

317-52-2






Bromide








Hexamethonium

60-26-4






Hexamidine

3811-75-4






Hexapropymate

358-52-1






Hexedine

5980-31-4






Hexestrol

84-16-2






Hexestrol Bis(b-

2691-45-4






diethylamino-








ethyl ether)








Hexethal

144-00-3






Hexetidine

141-94-6






Hexobarbital

56-29-1






Hexobendine

54-03-5






Hexocyclium 

115-63-9






Methyl Sulfate








Hexoprenaline

3215-70-1






Hextend
Hextend [CAS]
235746-51-7
U.S.
5,407,428
Plasma substitute
Surgery adjunct


Hexylcaine

532-76-3






HF-0299
11b-hydroxy androstenedione



Osteoporosis treatment
Osteoporosis


HGP-2
Benzeneacetic acid, 4-[2-hydroxy-3-[(1-
121009-31-2


Antiglaucoma
Glaucoma



methylethyl)amino]propoxy]-, 2-








tricyclo[3.3.1.13,7]dec-1-ylethyl ester,








(2Z)-2-butenedioate (1:1) (salt) [CAS]







HGP-6 
8-Azoniabicyclo[3.2.1]octane, 3-(3-
113932-41-5


Antiepileptic
Epilepsy, general



ethoxy-1,3-dioxo-2-phenylpropoxy)-8,8-








dimethyl-, (3-endo)-, methyl sulfate








[CAS]







hidrosmin
Hydrosmin-[CAS]
120250-44-4


Vasoprotective, 








systemic



histamine
histamine
51-45-6
EP
0493468
Anticancer, 
Cancer, melanoma







immunological



Histapyrrodine

493-80-1






histrelin
Luteinizing hormone-releasing factor
76712-82-8
EP
217659
Releasing hormones
Precocious puberty



(pig), 6-[1-(phenylmethyl)-D-histidine]-








9-(N-ethyl-L-prolinamide)-10-








deglycinamide-[CAS]







HM-101
HM 101 [CAS]
217311-70-1


Osteoporosis treatment
Osteoporosis


HMN-214
(E)-4-[2-[2-(p-



Anticancer, other
Cancer, general



methoxybenzenesulfonamide)-








phenyl]ethenyl]pyridine-1-oxide







Homatropine

87-00-3






Homocamfin

535-86-4






Homo-

848-53-3






chlorcyclizine








Hopantenic 

18679-90-8






Acid








HP-228
Glycinamide, N-acetyl-L-norleucyl-L-
172617-89-9
EP
759770
Analgesic, other
Pain, post-



glutaminyl-L-histidyl-D-phenylalanyl-L-




operative



arginyl-D-tryptophyl-[CAS]







Huperzine A

102518-79-6






hyaluronan
Hyaluronic acid [CAS]
9004-61-9


Formulation, other
Restenosis


Hycanthone

3105-97-3






Hydnocarpic 

459-67-6






Acid








Hydralazine

86-54-4






Hydrastine

118-08-1






Hydrastinine

6592-85-4






Hydrochloro-

58-93-5






thiazide








hydrocodone
Morphinan-6-one, 4,5-epoxy-3-hydroxy-
466-99-9


Formulation, modified-
Pain, general



17-methyl-,(5Alpha)-[CAS]
125-29-1


release, other



Hydrocortamate

76-47-1






hydrocortisone
Pregn-4-ene-3,20-dione, 21-(acetyloxy)
74050-20-7
DE
2826257
Dermatological
Unspecified



11-hydroxy-17-(1-oxopropoxy)-, (11β)-
50-23-7







[CAS]







hydrocortisone 
Pregn-4-ene-3,20-dione, 11-hydroxy-
72590-77-3
DE
2910899
Antipruritic/inflamm, 



butyrate propio
17-(1-oxobutoxy)-21-(1-oxopropoxy)-,



allergic




(11β)-[CAS]







Hydroflume-

135-09-1






thiazide








hydromorphone
Morphinan-6-one,4,5-epoxy-3-hydroxy-
103-90-2


Formulation, fixed-dose
Pain, general



17-methyl-,(5Alpha)-, mixt with
16590-41-3


combinations




acetamide, N-(4-hydroxyphenyl)-, mixt
466-99-9







with morphinan-6-one,17-








(cyclopropylmethyl)-4,5-epoxy-3,14-








dihydroxy-, (5Alpha)- 







Hydroquinidine

1435-55-8






Hydroquinine

522-66-7






Hydroquinone

123-31-9






Hydroxocob-

13422-51-0






alamin








Hydroxy-

1518-86-1






amphetamine








Hydroxy-

118-42-3






chloroquane








Hydroxydione

53-10-1






Hydroxy-

468-56-4






pethidine








Hydroxy-

50-19-1






phenamate








Hydroxypropyl 

9004-64-2






Cellulose








Hydroxystil-

495-99-8






bamidine








Hydroxy-

490-98-2






tetraceine








Hydroxyzine

68-88-2






Hylan G-F 20








Hymecromone

90-33-5






hyoscyamine
benzeneacetic acid,
101-31-5


Formulation, oral, orally-
Ulcer, GI, general



Alpha(hydroxymethyl)-, 8-methyl-B-



disintegrating




azabicyclo [3.2.1.]oct-3-yl ester, [3(S)-








endo],







hypericin
Phenanthro[1,10,9,8-opqra]perylene-
548-04-9


Anticancer, other
Cancer, brain



7,14-dione, 1,3,4,6,8,13-hexahydroxy-








10,11-dimethyl-[CAS]







IACFT

180468-34-2 






ibandronic 
Phosphonic acid, [1-hydroxy-3-
114084-78-5
EP
252504
Osteoporosis treatment
Hypercalcaemia of


acid
(methylpentylamino)propylidene] bis-




malignancy



[CAS]







ibopamine
Propanoic acid, 2-methyl-, 4-12-
66195-31-1
GB
1551661
Cardiostimulant
Heart failure



(methylamino)ethyl]-1,2-phenylene








ester-[CAS]







ibopamine
Propanoic acid, 2-methyl-, 4-[2-
66195-31-1


Formulation, mucosal, 
Surgery adjunct



(methylamino)ethyl]-12-phenylene



topical




ester-[CAS]







Ibritumomab 

206181-63-7






Tiuxetan








ibrolipim
Phosphonic acid, [[4-[[(4-bromo-2-
133208-93-2 
EP
402033
Hypolipaemic/
Hypertri-



cyanophenyl)amino]carbonyl]phenyl]



Antiatherosclerosis
glyceridaemia



methyl.).-, diethyl ester [CAS]







ibudilast
1-Propanone, 2-methyl-1-[2-(1-
50847-11-5
EP 
215438 
Antiasthma
Asthma



methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-








[CAS]







Ibufenac

1553-60-2






ibuprofen 
Benzeneacetic acid, Alpha-methyl-4-(2-
64622-45-3
DE
2658610
Antipruritic/inflamm, 
Eczema, contact


piconol
methylpropyl)-, 2-pyridinylmethyl ester



non-allergic




[CAS]







ibuprofen
Benzeneacetic acid, Alpha-methyl-4-(2-
15687-27-1


Formulation, modified-
Inflammation, 



methylpropyl)-[CAS]



release, other
general


Ibuproxam

53648-05-8






ibutilide
Methanesulfonamide, N-[4-[4-
122647-31-8
JP
60239458
Antiarrhythmic
Fibrillatioin, atrial



(ethylheptylamino)-1-
122647-32-9







hydroxybutyl]phenyl]-, (+/−)-, [CAS]







ICA-17043


U.S.
6,288,122
Antisickling
Anaemia, sickle cell


icodextrin
Dextrin-[CAS]
9004-53-9


Urological
Renal failure


idarubicin
5,1 2-Naphthacenedione, 9-acetyl-7-[(3-
58957-92-9
U.S.
4,471,052
Anticancer, antibiotic
Cancer, leukaemia, 



amino-2,3,6-trideoxy-Alpha-L-lyxo-
86189-66-4



acute lymphocytic



hexopyranosyl)oxy]-7,8,9,10-tetrahydro-








6,9,11-trihydroxy-, (7S-cis)-[CAS]







Idazoxan

79944-58-4






IdB-1016
2-(2,3-dihydro-2-(4-hydroxy-3-
134499-06-2
EP 
209038
Anticancer, hormonal
Cancer, ovarian



methoxyphenyl)-3-(hydroxymethyl)-1,4-








benzodioxin-6-yl)-2,3-dihydro-3,5,7-








trihydroxy-4H-1-benzopyran-4-one








phosphatidylcholine complex







idebenone
2,5-Cyclohexadiene-1,4-dione, 2-(10-
58186-27-9
EP
58057
Neuroprotective
Ischaemia, cerebral



hydroxydecyl)-5,6-dimethoxy-3-methyl-








[CAS]







IDN-5109
4-Hexenoic acid, 3-[[(1,1-
186348-05-0
U.S.
5,264,591
Anticancer, other
Cancer, colorectal



dimethylethoxy)carbonyl]amino]-2-








hydroxy-5-methyl-,








(3aS,4R,7R,8aS,9S,10aR,12aS,12bR,








13S,13aS)-7,12a-bis(acetyloxy)-13-








(benzoyloxy)-








3a,4,7,8,8a,9,10,10a,12,12a,12b,13-








dodecahydro-9-hydroxy-5,8a,14,14-








tetramethyl-2,8-dioxo-6,13a-methano-








13aH-oxeto [2′′,3′′,5′,6′] benzo[1,2:4,5]








cyclodeca [1,2-d] dioxyl-4-yl ester,








2R,3S) [CAS}







Idoxifene

116057-75-1






idraparinux
Alpha-D-Glucopyranoside, methyl O-
149920-56-9
AU
698456
Antithrombotic
Thrombosis, venous



2,3,4-tri-O-methyl-6-O-sulfo-Alpha-D-








glucopyranosyl-(1-4)-O-2,3-di-O-methyl








β-D-glucopyranuronosyl-(1-4)-O-2,3,6-








tri-O-sulfo-Alpha-D-glucopyranosyl-(1-








4)-O-2,3-di-O-methyl-Alpha-L-








idopyranuronosyl-(1-4)-, tris(hydrogen








sulfate) nonasodium salt [CAS]







idrocilamide
2-Propenamide, N-(2-hydroxyethyl)-3-
6961-46-2
U.S.
3,659,014
Anti-inflammatory, 




phenyl-[CAS]



topical



ifenprodil
(7)-2-(4-benzyl piperidino)-1-p-
23210-58-4
U.S.
3,509,164
Neuroprotective




hydroxyphenylpropanol tartrate
23210-56-2






ifosfamide
2H-1,3,2-Oxazaphosphonn-2-amine,
3778-73-2
U.S.
3,732,340
Anticancer, alkylating
Cancer, lung, general



N,3-bis(2-chloroethyl)tetrahydro-,2-








oxide [CAS]







iguratimod
N-[3-(Formylamino)-4-oxo-6-phenoxy-
123663-49-0 
DE
3834204
Antiarthritic, other
Arthritis, 



4H-chromen-7-yl] methanesulfonamide




rheumatoid


ilaprazole
1H-Benzimidazole, 2-(((4-methoxy-3-
172152-36-2
U.S.
5,703,097
Antiulcer
Ulcer, GI, general



methyl-2-pyridinyl) methyl)sulflnyl)-5-








(1H-pyrrol-1-yl)-[CAS]







ilomastat
Butanediamide, N4-hydroxy-N1-(1-(1H-
142880-36-2
U.S.
5,892,112
COPD treatment
Emphysema, 



indol-3-ylmethyl)-2-(methylamino)-2-




smoking-related



oxoethyl)-2-(2-methylpropyl)-, (S-(R*,








S*))-[CAS]







iloperidone
Ethanone, 1-[4-[3-[4-(6-fluoro-1,2-
133454-47-4
U.S.
5,776,963
Neuroleptic
Schizophrenia



benzisoxazol-3-yl)-1-








piperidinyl]propoxy]-3-methoxyphenyl]-








[CAS]







iloprost 
Pentanoic acid, 5-[hexahydro-5-
78919-13-8
DE
3,417,638
Prostaglandin
Peripheral vascular 


trometamol
hydroxy-4-(3-hydroxy-4-methyl-1-octen-




disease



6-ynyl)-2(1H)-pentalenylidene]-[CAS]







ILX23-7553
1Alpha,25-Hydroxy-16-yne vitamin D3



Anticancer, other
Cancer, general


imatinib
4-((Methyl-1-piperazinyl)methyl)-N-[4-
152459-95-5
U.S.
5,521,184
Anticancer, other
Cancer, leukaemia, 



methyl-3-[[4-(3-pyridinyl)-2-




chronic



pyrimidinyl]amino]-phenyl]benzamide




myelogenous



methanesulfonate







imidapril
4-Imidazolidinecarboxylic acid, 3-[2-[[1-
89371-37-9
EP
95163
Antihypertensive, renin 
Hypertension, 



(ethoxycarbonyl)-3-phenylpropyl]amino]
89396-94-1


system, 
general, Cachexia



1-oxopropyl]-1-methyl-2-oxo-, [4S-



Musculoskeletal




[3[R*(R*)],4R*]]-[CAS]







imidazole 
Benzoic acid, 2-hydroxy-, compd. with
36364-49-5
U.S.
4,329,340
Anti-inflamatory
Pain, general


salicylate
1H-imidazole (1:1) [CAS]







imipenem
1-Azabicyclo[3.2.0]hept-2-ene-2-
64221-86-9
GB
1570990
Beta-lactam antibiotic
infection, general



carboxylic acid, 6-(1-hydroxyethyl)-3-[[2-
74431-23-5







[(iminomethyl)amino]ethyl]thio]-7-oxo-,
81129-83-1







[5R-[5Alpha,6Alpha(R* )]]-[CAS]







Imipramine

50-49-7






Imipramine 

6829-98-7






N-Oxide








imiquimod
1H-Imidazo[4,5-c]quinolin-4-amine, 1-
99011-02-6
EP
145340
Antiviral, other
Infection, human 



(2-methylpropyl)-[CAS]




papilloma virus


Imolamine

318-23-0






implitapide
Benzeneacetamide, Alpha-cyclopentyl-
177469-96-4
EP
705831
Hypolipaemic/
Atherosclerosis



4-((2,4-dimethyl-9H-pyrido(2,3-b)indol-



Antiatherosclerosis




9-yl)methyl)-N-((1R)-2-hydroxy-1-








phenylethyl)- (AlphaS)-[CAS]







Improsulfan

13425-98-4






Inaperisone

99323-21-4






incadronate
Phosphonic acid,
138330-18-4


Musculoskeletal
Hypercalcaemia of



[(cycloheptylamino)methylene]bis-,




malignancy



[CAS]







Incadronic 

124351-85-5






Acid








Indalpine

63758-79-2






Indanazoline

40507-78-6






indapamide
4-chloro-N-(2-methylindolin-1-yl)-3-
26807-65-8
GB
1203691
Antihypertensice, 
Hypertension, 



sulfamoylbenzamide



diuretic
general


Indecainide

74517-78-5






indeloxazine
Morptioline, 2-[(1H-inden-7-
60929-23-9
JP
52083773
Cognition enhancer
Alzheimer's 



yloxy)methyl]-[CAS]
65043-22-3



disease


Indeloxazine

65043-22-3






indenolol
2-Propanol, 1-[1H-inden-4(or 7)-yloxy]-
30190-87-5
GB
1290343
Antihypertensive, 




3-[(1-methylethyl)amino]-[CAS]
60607-68-3


adrenergic





68906-88-7






indinavir
D-erythro-Pentonamide, 2,3,5-trideoxy-
150378-17-9
EP 
0541168 
Antiviral, anti-HIV
Infection, HIV/AIDS



N-(2,3-dihydro-2-hydroxy-1H-inden-1-
157810-81-6







dimethylethyl)amino)carbonyl)-4-(3-








pyridinylmethyl)-1-piperazinyl)-2-








(phenylmethyl), [1S-








[1Alpha(R*),2Alpha]]-, [CAS]







indiplon
Acetamide, N-methyl-N-(3-(3-(2-
325715-02-4
US 
6,399,621
Hypnotic/Sedative
Insomnia



thienylcarbonyl)pyrazolo(1,5-a)








pyrimidin-7-yl)phenyl)-[CAS]







indisetron
1H-Indazole-3-carboxamide, N-(3,9-
160472-97-9


Antiemetic
Nausea and vomiting,



dimethyl-3,9-diazabicyclo(3.3.1)non-7-




general



yl)-, diendo-[CAS]







indisulam
1,4-Benzenedisulfonamide, N-(3-chloro-
165668-41-7


Anticancer, other
Cancer, lung, 



IH-indoi-7-yl)-[CAS] 




non-small cell


Indobufen

63610-08-2






Indocyanine 

3599-32-4






Green








indometacin
1H-lndole-3-acetic acid, 1-(4-
53-86-1


Formulation, modified-
Inflammation, general



chlorobenzoyl)-5-methoxy-2-methyl-



release, other




[CAS] 







Indoprofen

31842-01-0






indoramin
Benzamide, N-[1-[2-(1H-indol-3-
26844-12-2
GB
1218570
Antihypertensive, 




yl)ethyl]-4-pipendinyl]-[CAS]
38821-52-2


adrenergic



Inducterm


U.S.
5,993,810
Labour inducer
Labour, induction


Infliximab

170277-31-3






Inosine 

36703-88-5






Pranobex








Inositol

87-89-8






Inositol 

6556112






Niacinate








Iobenguane

80663-95-2






Iobenzamic 

3115057






Acid








Iobitridol

136949-58-1






Iocarmic 

10397-75-8






Acid








Iocetamic 

16034-77-8






Acid








Iodamide

440-58-4






Iodine
Iodine [CAS]
7553-56-2


Formulation, oral, other
Fibrocystic breast 








disorder


Iodipamide

606-17-7






Iodixanol

92339-11-2






Iodoalphionic 

577-91-3






Acid








iodochlor-
5-Chloro-7-iodo-8-quinolinol
130-26-7


Cognition enhancer
Alzheimer's disease


hydroxyquin








Iodoform

75-47-8






Iodopyracet

300-37-8






Iodopyrrole

87-58-1






Iodoquinol

83-73-8






Iofetamine 

75917-92-9






123I








Ioglycamic 

2618-25-9






Acid








Iohexol

66108-95-0






Iomeglamic 

25827-76-3






Acid








Iomeprol

78649-41-9






Iopamidol

60166-93-0






Iopanoic Acid

96-83-3






Iopentol

89797-00-2






Iophendylate

99-79-6






Iophenoxic 

96-84-4






Acid








Iopromide

73334-07-3






Iopronic Acid

41473-08-9






Iopydol

5579-92-0






Iopydone

5579-93-1






Iothalamic 

2276-90-6






Acid








Iotrolan

79770-24-4






Ioversol

87771-40-2






Ioxaglic Acid

59017-64-0






Ioxilan

107793-72-6






IP-751
(3R,4R)-(delta6)-THC-DMH-11-oic acid 

WO
9401429
Analgesic, other
Pain, neuropathic


Ipidacrine

62732-44-9






IPL-576092
Stigmastan-15-one, 22,29-epoxy-
137571-30-3
U.S.
6,046,185
Antiasthma
Asthma



3,4,6,7,29-pentahydroxy-,








(3Alpha,4β,5Alpha,6Alpha,7β,14β,








22S)-[CAS]







Ipodate

5587-89-3






ipratropium 

66985-17-9


Formulation, inhalable, 
Chronic obstructive


bromide

22254-24-6


solution
pulmonary disease


ipratropium
(endo,syn)-(±)-3-(3-Hydroxy-1-oxo-2-



Formulation, inhalable, 
Asthma



phenylpropoxy)-8-methyl-8-(1-



topical




methylethyl)-8-








azoniabicyclo(3.2.1]octane







iprazochrome
Hydrazinecarboxamide, 2-[1,2,3,6-
7248-21-7


Haemostatic




tetrahydro-3-hydroxy-1-(1-methylethyl)-








6-oxo-5H-indol-5-ylidene]-[CAS]







ipriflavone
4H-1-Benzopyran-4-one, 7-(1-
35212-22-7
EP
214647
Osteoporosis treatment
Osteoporosis



methylethoxy)-3-phenyl-[CAS]







Iprindole

5560-72-5






Iproclozide

3544-35-2






Iproniazid

54-92-2






Ipsapirone

95847-70-4






irbesartan
2-n-butyl-4-spirocyclopentane-1-[((2′-
138402-11-6
WO
9114679
Antihypertensive, renin 
Hypertension, 



tetrazol-5-yl)biphenyl-4-yl)methyl]-2-



system
general



imidazolin-5-one 







IRFI-042
Butanedioic acid, mono[2-[2-
134867-62-2
U.S.
5,114,966
Cardiovascular
Antherosclerosis



(acetylthio)ethyl]-2,3-dihydro-4,6,7-








trimethyl-5-benzofuranyl] ester, (+/−)-








[CAS]







IRFI-165
N-Cyclopentyl-1-methylimidazo[1,2-
191349-26-5
EP
865442
Antidepressant
Depression, general



a]quinoxalin-4-amine







Iridomyrmecin

485-43-8






irindalone
-Imidazolidinone, 1-[2-[4-[3-(4-
104113-57-7
EP
183349
Antidepressant
Depression, general



fluorophenyl)-2,3-dihydro-1H-inden-1-
96478-43-2







yl]-1-piperazinyl]ethyl]-, (1R-trans)-








[CAS]







Irinotecan

97682-44-5






irofulven
Spiro[cyclopropane-1,5-[5H]inden]-
125392-76-9
U.S.
5,563,176
Anticancer, other
Cancer, prostate



7′(6′H)-one, 6′-hydroxy-2′,4′,6-trimethyl,








(R)-[CAS]







Iron Sorbitex

1338-16-5






irsogladine
1,3,5-Triazine-2,4-diamine, 6-(2,5-
57381-26-7
U.S.
4,657,907
Antihypertensive, 
Hypertension, 



dichlorophenyl)-[CAS]
57381-28-9


diuretic
general




57381-33-6






IS-741
Cyclohexanecarboxamide, N-[2-
141283-87-6
EP
465913
GI inflammatory/bowel 
Pancreatitis



[(ethylsulfonyl)amino]-5-



disorders




(trifluoromethyl)-3-pyridinyl)-[CAS]







isaglitazone
2,4-Thiazolidinedione, 5-[[6-[(2-
161600-01-7
U.S.
5594016
Antidiabetic
Diabetes, Type II



fluorophenyl)methoxy]-2-








naphthalenyl]methyl]-[CAS]







ISAtx-247


NZ
502362
Immunosuppressant
Transplant rejection, 








general


Isbogrel

89667-40-3






isepamicin
D-Streptamine, O-6-amino-6-deoxy-
58152-01-5
U.S.
4,029,882
Aminoglycoside 
Infection, fungal, 



Alpha-D-glucopyranosyl-(1-4)-O-[3-
58152-03-7


antibiotic
general



deoxy-4-C-methyl-3-(methylamino)-β-L








arabinopyranosyl-(1-6)1-N1-(3-amino-2-








hydroxy-1-oxopropyl)-2-deoxy-, (S)-








[CAS]







Isoaminile

77-51-0






Isobutyl p-

94-14-4






Aminobenzoate








Isocarboxazid

59-63-2






isoconazole
1-[2-(2-6-dichlorobenzyloxy)-2-(2-,4-
24168-96-5
GB
1244530
Antifungal
Infection, fungal, 



dichlorophenyl)ethyl]
27523-40-6



general


Isoetharine

530-08-5






isofloxythepin
1-Piperazineethanol, 4-[3-fluoro-10,11-
106819-39-0
GB
2010843
Neuroleptic




dihydro-8-(1-
106819-41-4







methylethyl)dibenzo[b,f]thiepin-10-yl]-
70931-18-9







[CAS]







isoflurane
Ethane, 2-chloro-2-(difluoromethoxy)-
26675-46-7 
U.S.
3,535,388
Anaesthetic, inhalation
Anaesthesia



1,1,1-trifluoro-[CAS]







Isoflurophate

55-91-4






Isoladol

530-34-7






Isomethadone

466-40-0






Isometheptene

503-01-5






Isoniazid

54-85-3






Isonixin

57021-61-1






Isopromethazine

303-14-0






Isopropamide 

71-81-8






Iodide








Isopropyl 

67-63-0






Alcohol








isopropyl 
5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3
120373-24-2
EP
289349
Prostaglandin
Glaucoma


unoprostone
oxodecyl)cyclopentyl)-, 1-








methylethylester, (1R-(1Alpha(Z),








2β,3Alpha,5Alpha))-[CAS]







Isoproterenol

7683-59-2






Isosorbide

652-67-5






isosorbide 
D-Glucitol, 1,4:3,6-dianhydro-, dinitrate
87-33-2


Formulation, modified-
Angina, general


dinitrate
[CAS]



release, other



isosorbide 
D-Glucitol, 1,4:3,6-dianhydro-, 5-nitrate
16051-77-7


Formulation, modified-
Angina, general


mononitrate
[CAS]



release, other



Isothipendyl

482-15-5






isotretinoin
Retinoic acid, 13-cis-[CAS]
4759-48-2
U.S.
4,843,096
Antiacne
Acne


Isovaleryl 

533-32-4






Diethylamide








Isoxepac

55453-87-7






Isoxicam

34552-84-6






lsoxsuprine

395-28-8






isradipine
3,5-Pyridinedicarboxylic acid, 4-(4-
75695-93-1
GB
2037766
Antihypertensive, other
Hypertension, 



benzofurazanyl)-1,4-dihydro-2,6-




generation



dimethyl-, methyl 1-methylethyl ester








[CAS]







israpafant
6H-Thienol3,2-f][l,2,4]triazolo[4,3-
117279-73-9
EP
268242
Antiasthma
Asthma



a][1,4]diazepine, 4-(2-chlorophenyl)-6,9-








dimethyl-2-[2-[4-(2-








methylpropyl)phenyl]ethyl]-[CAS]







ISV-403


U.S.
5,447,926
Formulation, mucosal, 
Conjunctivitis







topical



Itasetron

123258-84-4






ITF-282
ITF 282 [CAS]
93615-44-2
GB
2115821
Antianaemic
Anaemia, general


itopride
Benzamide, N-[[4-[2-
122892-31-3
EP
306827
Gastroprokinetic
Gastritis



(dimethylamino)ethoxy]phenyl]methyl]-








3,4-dimethoxy-, monohydrochloride








[CAS]







itraconazole
3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[2-
84625-61-6
EP
6711
Antifungal
Infection, fungal, 



(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-




general



1-ylmethyl)-1,3-dioxolan-4-








yl]methoxy]phenyl]-1-








piperazinyl]phenyl]-2,4-dihydro-2-(1-








methylpropyl)-[CAS]







Itramin

13445-63-1






itriglumide
1-Naphthalenepropanoic acid, β-[2-[[2-
201605-51-8
WO
9800404
Anxiolytic
Anxiety, general



(8-azaspiro[4.5]dec-8-ylcarbonyl)-4,6-








dimethylphenyl]amino]-2-oxoethyl]-,








(βR)-[CAS]







iturelix
D-Alaninamide N-acetyl-3-(2-
112568-12-4
WO
8901944
Fertility enhancer
Infertility, female



naphthalenyl)-D-alanyl-4-chloro-D-








phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-








seryl-N6-(3-pyridinylcarbonyl)-L-lysyl-








N6-(3-pyridinylcarbonyl)-D-lysyl-L-








leucyl-N6-(1-methylethyl)-L-lysyl-L-








prolyl-[CAS]







ivabradine
7,8-dimethoxy-3-(3-[[(1S)(4,5-



Antianginal
Anginal, general



dimethoxybenzocyclobutan-1-








yl)methyl]methylamino]propyl)-1,3,4,5-








tetrahydro-2H-benzazepin-2-one







ixabepilone
17-Oxa-4-
219989-84-1


Anticancer, other
Cancer, breast



azabicyclo(14.1.0)heptadecane-5,9-








dione, 7,11-dihydroxy-8,8,10,12,16-








pentamethyl-3-(1-methyl-2-(2-methyl-4-








thiazolyl)ethenyl,








(1R,3S,7S,10R,11S,12S,16R) [CAS]







J-104132
5H-Cyclopenta[b]pyridine-6-carboxylic
198279-45-7
WO
9737665
Antihypertensive, 
Heart failure



acid, 5-(1,3-benzodioxol-5-yl)-2-butyl-7-



other




[2[(2S)-2-carboxypropyl]-4-








methoxyphenyl]-6,7-dihydro-,








(5S,6R,7R)-[CAS]







J-107088
5H-Indolo(2,3-a)pyrrolo(3,4-
174402-32-5


Anticancer, other
Cancer, bladder



c)carbazole-5,7(6H)-dione, 12-β-D-








glucopyranosyl-12,13-dihydro-2,10-








dihydroxy-6-((2-hydroxy-1-








(hydroxymethyl)ethyl)amino-[CAS]







J-113397
1-[(3R,4R)-1-Cyclooctylmethyl-3-



Analgesic, other
Pain, general



hydroxymethyl-4-piperidyl]-3-ethyl-1,3-








dihydro-2H-benzimidazole-2-one







Janex-1
Phenol, 4-[(6,7-dimethoxy-4-
202475-60-3


Anticancer, other
Cancer, leukaemia, 



quinazolinyl)amino]-[CAS]




general


josamycin
Leucomycin V, 3-acetate 4B-(3-
16846-24-5
JP
41021759
Macrolide antibiotic
Infection, general



methylbutanoate) [CAS]







JTV-519
1,4-Benzothiazepine, 2,3,4,5-
145903-06-6
WO
9212148
Cardiovascular
Infarction, myocardial



tetrahydro-7-methoxy-4-[1-oxo-3-[4-








(phenylmethyl)-1-piperidinylipropyl]-








[CAS]







K-777


U.S.
6,287,840
Protozoacide
Infection, 








trypanosomiasis,








American


Kainic Acid

487-79-6






Kalimate
Kalimate-[CAS]
92354-70-6


Urological



Kallidin

342-10-9






KB-130015
Acetic acid (2,6-diiodo-4-((2-methyl-3-
147030-48-6


Antiarrhythmic
Arrhythmia, general



benzofuranyl)methyl)phenoxy)-[CAS]







KCB-328
Methanesulfonamide, N-[3-amino-4-[2-
177596-55-3
WO
9604231
Antiarrhythmic
Arrythmia, general



[[2-(3,4-








dimethoxyphenyl)ethyl]methylamino]








ethoxylphenyl]-, monohydrochloride








[CAS]







Kebuzone

853-34-9






ketamine
2-(2-Chlorophenyl)-2-(methylamino)-
6740-88-1


Formulation, 
Pain, post-operative



cyclohexanone hydrochloride



transmucosal, 








nasal



ketanserin
2,4(1H,3H)-Quinazolinedione, 3-[2-[4-
74050-98-9
EP
13612
Antihypertensive, other
Hypertension, 



(4-fluorobenzoyl)-1-piperidinyl]ethyl]-
83846-83-7



general



[CAS]







ketazolam
4H-[1,3]Oxazino[3,2-
27223-35-4
GB 
1222294
Anxiolytic




d][1,4]benzodiazepine-4,7(6H)-dione,








11-chloro-8,12b-dihydro-2,8-dimethyl-








12b-phenyl-[CAS]







Kethoxal

27762-78-3






Ketobemidone

469-79-4






ketoconazole
Piperazine, 1-acetyl-4-[4-[[2-(2,4-
65277-42-1
U.S.
4,335,125
Antifungal
Infection, fungal, 



dichlorophenyl)-2-(1H-imidazol-1-




general



ylmethyl)-1,3-dioxolan-4-








yl]methoxy]phenyl]-, cis-[CAS]







ketoprofen
mono(3-benzoyl-Alpha-
173011-11-5
EP
502502
Formulation, 
Pain, general



methylbenzeneacetate) [CAS]



transdermal, 








systemic



ketorolac
1H-Pyrrolizine-1-carboxylic acid, 5-
74103-06-3
EP
53021
Analgesic, NSAID




benzoyl-2,3-dihydro-, (+/−)-[CAS]
74103-07-4






Ketorolac 








Tromethamine








ketotifen
10-H-Benzo[4,5]cyclohepta[1,2-
34580-13-7
GB
1355539
Antiasthma




b]thiophen-10-one, 4,9-dihydro-4-(1-
34580-14-8







methyl-4-piperidinylidene)-, (E)-2-








butenedioate (1:1)-[CAS]







Khellin

82-02-0






kinetin

9001-29-0


Dermatological
Photodamage


KNI-272
4-Thiazolidinecarboxamide, N-(1,1-
147318-81-8
U.S.
5,644,028
Antiviral, anti-HIV
Infection, HIV/AIDS



dimethylethyl)-3-[2-hydroxy-3-[[2-[[(5-








isoquinolinyloxy)acetyl]amino]-3-








(methylthio)-1-oxopropyl]amino]-1-oxo-








4-phenylbutyl]-, [4R-








[3[2S*,3S*(R*)],4R*]]-[CAS]







KP-103
(R,R)-2-(2,4-Difluorophenyl)-3-(4-



Antifungal
Infection, general



methylenepiperidin-1-yl)-1-(1,2,4-triazol








1-yl)-2-butanol







KP-157


U.S.
6,110,961
Antidepressant
Depression, general


KP-544


WO
9919305
Cognition enhancer
Unspecified


KRN-5500
L-glycero-β-L-manno-
151276-95-8
WO
9015811
Anticancer, antibiotic
Cancer, colorectal



Heptopyranosylamine, 4-deoxy-4-








[[[[(2E,4E)-1-oxo-2,4-








tetradecadienyl]amino]acetyl]amino]-N-








1H-purin-6-yl-[CAS]







KT-136
Alpha-D-Glucopyranoside, β-D-
121602-88-8


Formulation, dermal, 
Ulcer, decubitus



fructofuranosyl, mixt. with 1-ethenyl-2-



topical




pyrrolidinone homopolymer compd.








with iodine [CAS]







KUL7211
(−)-2-[(2S)-1,2,3,4-tetrahydro-2-[[(2R)-2



Urological
Urinary calculus



hydroxy-2-(4-








hydroxphenyl)ethyl]amino]naphthalen-7-








yloxy]-N,N-dimethylacetamide








hydrochloride monohydrate







KW-2170
6H-Pyrazolo[4,5,1-de]acridin-6-one,5-
207862-44-0


Anticancer, 
Cancer, lung, 



[(3-aminopropyl)amino]-7,10-dihydroxy-



alkylating
non-small cell



2-[[(2-hydroxyethyl)amino]methyl]-,








dihydrochloride [CAS]







KW-6002
1H-Purine-2,6-dione, 8-(2-(3,4-
155270-99-8


Antiparkinsonian
Parkinson's disease



dimethoxyphenyl)ethenyl)-1,3-diethyl-








3,7-dihydro-7-methyl- (E)-[CAS]







KW-71 58
3,3,3-Trifluoro-2-hydroxy-2-methyl-N-



Urological
Incontinence



(10-oxo-4,10-dihydrothieno[3,2-C][1]








benzothiepin-9-yl)propanamide 5,5








dioxide







L-365260
Urea, N-(2,3-dihydro-1-methyl-2-oxo-5-
118101-09-0
EP
284256
Anticancer, other
Cancer, general



phenyl-1H-1,4-benzodiazepin-3-yl)-N′-








(3-methylphenyl)-, (R)-[CAS]







L-5-
L-Tryptophan, 5-hydroxy-[CAS]
4350-09-8


Metabolic and enzyme 
Unspecified


hydroxy-




disorders



tryptophan








L-745337
Methanesulfonamide, N-[6-[(2,4-
158205-05-1
WO
9413635
Analgesic, NSAID
Pain, general



difluorophenyl)thio]-2,3-dihydro-1-oxo-








1H-inden-5-yl]-[CAS]







L-758298
Phosphonic acid, [3-fl(2R,3S)-2-.(.(1R)
172673-20-0
WO
9523798
Antiemetic
Chemotherapy-



1-[3,5-




induced nausea 



bis(trifluoromethyl)phenyl]ethoxy]-3-(4-




and vomiting



fluorophenyl)-4-morpholinyl]methyl]-








2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-








[CAS]







L-826141


WO
9722585
Antiasthma
Unspecified


labetalol
5-[1-hydroxy-2-[(1-methyl-3-
32780-64-6
U.S.
4,012,444
Antihypertensive, 




phenylpropyl)amino]ethyl]salicylamide
36894-69-6


adrenergic




HCl







lacidipine
3,5-Pyridinedicarboxylic acid, 4-[2-[3-
103890-78-4 
GB
2164336
Antihypertensive, other
Hypertension, 



(1,1-dimethylethoxy)-3-oxo-1-




general



propenyl]phenyl]-1,4-dihydro-2,6-








dimethyl-, diethyl ester, (E)-[CAS]







Lactic Acid








lactitol
D-Glucitol, 4-O-β-D-galactopyranosyl-
585-86-4


Hepatoprotective
Infection, 



[CAS]




neurological


Lactulose

46 18-18-2






lafutidine
Acetamide, 2-[(2-furanylmethyl)sulfinyl]-
118288-08-7
EP
282077
Antiulcer
Ulcer, gastric



N-[4-[[4-(1-pipendinylmethyl)-2-
169899-19-8







pyridinyl]oxy]-2-butenyl]-, (Z)-[CAS]







Lamifiban

1444 12-49-7






lamivudine
2(1H)-Pyrimidinone, 4-amino-1-[2-
134678-17-4
EP
513917
Antiviral, anti-HIV
Infection, HIV/AIDS



(hydroxymethyl)-1,3-oxathiolan-5-yl]-,








(2R-cis)-[CAS]







lamotrigine
1,2,4-Triazine-3,5-diamine, 6-(2,3-
84057-84-1
EP
21121
Antiepileptic
Epilepsy, partial 



dichlorophenyl)-[CAS]




(focal, local)


landiolol
Benzenepropanoic acid, 4-[2-hydroxy-3-
133242-30-5
EP
397031
Antiarrhythmic
Tachycardia, general



morpholinylcarbonyl)amino]ethyl]amino]








propoxy]-, (2,2-dimethyl-1,3-dioxolan-4-








yl)methyl ester, [S-(R*,R*)]- HCL







lanicemine
(S)-Alpha-phenyl-2-pyridine
153322-05-5


Neurological
Unspecified



ethanamine dihydrochloride







laniquidar
Methyl 6,11-dihydro-11-11-[2-[4-(-2-
197509-46-9
WO
9734897
Radio/
Cancer, general



quinolylmethoxy)phenyl]ethyl]-4-



chemosensitizer




piperidinylidene]-5H-imidazo[2,1-








b][3]benzazepine-3-carboxylate







lanoconazole
1H-Imidazole-1-acetonitrile, Alpha-[4-(2
101530-10-3
U.S.
4,738,976
Antifungal
Infection, fungal, 



chlorophenyl)-1,3-dithiolan-2-ylidene]-,




general



(E)-(±)-[CAS]







Lanoteplase

171870-23-8






Lanreotide

108736-35-2






lansoprazole
1H-Benzimidazole, 2-[[[3-methyl-4-
103577-45-3
EP
174726
Antlulcer
Ulcer, duodenal



(2,2,2-trifluoroethoxy)-2-








pyridyl]methyl]sulflnyl]-[CAS]







lanthanum 
Carbonic acid, lanthanum(3+) salt
587-26-8
U.S.
5,968,976
Urological
Hyperphosphat-


carbonate
(3:2)[CAS]




aemia


lapatinib
4-Quinazolinamine, N-[3-chloro-4-[(3-
388082-78-8


Anticancer, other
Cancer, breast



fluorobenzyl)methoxy phenyl]-6-[5-[[[2-








[methylsulfonyl]ethyl]amino]methyl]








furan-2-yl]







laquinimod

248281-84-7


Multiple sclerosis 
Multiple sclerosis, 







treatment
general


lasofoxifene
2-Naphthalenol, 5,6,7,8-tetrahydro-6-
190791-29-8
WO
9716434
Menopausal disorders
Hormone 



phenyl-5-(4-(2-(1-




replacement



pyrrolidinyl)ethoxy)phenyl-(5R-cis)-, (5-




therapy



(R*, R*))-2,3-dihydroxybutanedioate








[CAS]







latamoxef
5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-
64952-97-2
GB
1547351
Beta-lactam antibiotic
Infection, general



carboxylic acid, 7-[[carboxy(4-
64953-12-4







hydroxyphenyl)acetyl]amino]-7-








methoxy-3-[[(1-methyl-1H-tetrazol-5- 








yl)thio]methyl]-8-oxo-[CAS]







latanoprost
5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-
130209-82-4
WO
9002553
Prostaglandin
Glaucoma



hydroxy-5-phenylpentyl)cyclopentyl)-, 1








methylethyl ester, (1R-








(1Alpha(Z),2β(R*),3Alpha,5Alpha))-








[CAS]







Lauroguadine

135-43-3






Laurolinium 

146-37-2






Acetate








Lawsone

83-72-7






LAX-111
1-(Z,Z,Z,Z,Z-eicosa-5,8,11,14,17-



Neuroleleptic
Schizophrenia



pentaenoyloxy)-3-(Z,Z,Z,Z,Z-eicosa-








5,8,11,14,17-pentaenoyloxy)-propane







Lazabemide

103878-84-8






LB-30057
Benzenecarboximidic acid, 4-[(2S)-3-

WO
9749673
Antithrombotic
Thrombosis, venous



(cyclopentylmethylamino)-2-[(2-








naphthalenylsulfonyl)amino]-3-








oxopropyl]-, hydrazide [CAS]







L-Cystine








Lefetamine

7262-75-1






leflunomide
4-Isoxazolecarboxamide, 5-methyl-N-[4-
75706-12-6
EP
13376
Antiarthritic, 
Arthritis, 



(trifluoromethyl)phenyl]-[CAS]



immunological
rheumatoid


leflunomide
4-Isoxazolecarboxamide, 5-methyl-N-[4-
104981-93-3
U.S.
5,610,173
Anticancer, other
Cancer, ovarian



(trifluoromethyl)phenyl]-[CAS]
75706-12-6






Leiopyrrole

5633-16-9






lenampicillin
4-Thia-1-azabicyclo[3.2.0]heptane-2-
80734-02-7
EP
61206
Penicillin, oral
Infection, general



carboxylic acid, 6-
86273-18-9







[(aminophenylacetyl)amino]-3,3-








dimethyl-7-oxo-, (5-methyl-2-oxo-1,3-








dioxol-4-yl)methyl ester, [2S-








[2Alpha,5Alpha,6β(S*)]]-[CAS]







lentinan
Lentinan [CAS]
37339-90-5


Anticancer, 
Cancer, stomach







immunological



Lepirudin








lercanidipine
3,5-Pyridinedicarboxylic acid, 1,4-
100427-26-7
U.S.
4,705,797
Antihypertensive, 
Hypertensive, 



dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,
132866-11-6


other
general



2-[(3,3-diphenylpropyl)methylamino]-








1,1-dimethylethyl methyl ester-, 








hydrochloride [CAS]







lerisetron
1H-Benzimidazole, 1-(phenylmethyl)-2-
143257-98-1
U.S.
5,256,665
Antiemetic
Nausea and 



(1-piperazinyl)-[CAS]




vomiting general


Lesopitron

132449-46-8






leteprinim
Benzoic acid, 4-((3-(1,6-dihydro-6-oxo-
138117-50-7
U.S.
6,338,963
Antiparkinsonian
Parkinson's disease



9H-purin-9-yl)-1-oxopropyl)amino)-,








monopotassium salt [CAS]







letosteine
4-Thiazolidinecarboxylic acid, 2-[2-[(2-
53943-88-7
U.S.
4,032,534
COPD treatment
Bronchitis, chronic



ethoxy-2-oxoethyl)thio]ethyl]-[CAS]







letrozole
Benzonitrile, 4,4′-(1H-1,2,4-triazol-1-
112809-51-5
EP
236940
Anticancer, hormonal
Cancer, breast



ylmethylene)bis-[CAS]







Leucocyanidin

480-17-1






Leuprolide

53714-56-0






leuprolide 
Luteinizing hormone-releasing factor
53714-56-0


Formulation, implant
Cancer, prostate


acetate
(pig), 6-D-leucine-9-(N-ethyl-L-
74381-53-6







prolinamide)-10-deglycinamide-,








monoacetate (salt) [CAS]







leuprorelin
Luteinizing hormone-releasing factor
53714-56-0 


Formulation, implant
Cancer, prostate



(pig), 6-D-leucine-9-(N-ethyl-L-








prolinamide)-10-deglycinamide-[CAS]







Levallorphan

152-02-3






levamisole
Imidazo[2,1-blthiazole, 2,3,5,6-
14769-73-4
U.S.
4,584,305
Anthelmintic
Infection, helminth, 



tetrahydro-6-phenyl-, (5)-[CAS]
16595-80-5



general


Levcromakalim

94535-50-9






levetiracetam
1-Pyrrolidineacetamide, Alpha-ethyl-2-
102767-28-2
EP
162036
Antiepileptic
Epilepsy, general



oxo-, (5)-[CAS]







levobetaxolol
2-Propanol, 1-(4-(2-
116209-55-3


Formulation, mucosal, 
Glaucoma



(cyclopropylmethoxy)ethyl)phenoxy)-3-



topical




((1-methylethyl)amino) hydrochloride








[CAS]







levobunolol
1(2H)-Naphthalenone, 5-[3-[(1,1-
27912-14-7
U.S.
3,641,152
Formulation, mucosal, 
Glaucoma



dimethylethyl)amino]-2-
47141-42-4


topical




hydroxypropoxy]-3,4-dihydro-, (S)-








[CAS]







levobupivacaine
2-Piperidinecarboxamide, 1-butyl-N-
27262-47-1
WO
9510276
Anaesthetic, injectable
Anaesthesia



(2,6-dimethylphenyl)-, (5)-[CAS]







levocabastine
4-Piperidinecarboxylic acid, 1-[4-cyano-
79449-98-2
U.S.
4,369,184
Antiallergic, non-
Rhinitis, allergic, 



4-(4-fluorophenyl)cyclohexyl]-3-methyl-
79516-68-0


asthma
general



4-phenyl-, [3S-[1(cis),3Alpha,4β]]-
79547-78-7







[CAS]







levocetirizine
Acetic acid, (2-(4-((4-
130018-77-8
WO
9406429
Antiallergic, non-
Allergy, general



chlorophenyl)phenylmethyl)-1-



asthma




piperazinyl)ethoxy)-, (R)-[CAS]







Levodopa

59-92-7






levodropropizine
1,2-Propanediol, 3-(4-phenyl-1-
99291-25-5
EP
147847
Antitussive
Cough



piperazinyl)-, (5)-[CAS]







levofloxacin
7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6
100986-85-4
EP
206283
Quinolone 
Infection, respiratory 



carboxylic acid, 9-fluoro-2,3-dihydro-3-
138199-71-0


antibacterial
tract, lower



methyl-10-(4-methyl-1-piperazinyl)-7-








oxo-, (5)-[CAS]







Levomethadyl 

1477-40-3






Acetate








levomoprolol
2-Propanol, 1-(2-methoxyphenoxy)-3-
27058-84-0
EP
15418
Antihypertensive, 




[(1-methylethyl)amino]-, (5)-[CAS]
5741-22-0


adrenergic





77164-20-6






levonorgestrel
18,19-Dinorpregn-4-en-20-yn-3-one,
797-63-7


Formulation, implant
Contraceptive, 



13-ethyl-17-hydroxy-, (17Alpha)-[CAS]




female


Levophace-

24558-01-8






toperane








Levopro-

2338-37-6






poxyphene








Levorphanol

77-07-6






levosimendan
Propanedinitrile, (14-(1,4,5,6-tetrahydro-
131741-08-7
EP
383449
Cardiostimulant
Heart failure



4-methyl-6-oxo-3-
141505-33-1







pyridazinyl)phenyl]hydrazono]-, (R)-








[CAS]







levosulpiride
Benzamide, 5-(aminosulfonyl)-N-[(1-
23672-07-3
GB
2014990
Antiemetic
Dyspepsia



ethyl-2-pyrrolidinyl)methyl]-2-methoxy-,








(S)-[CAS]







Levothyroxine








levovirin
1-β-L-ribofuranosyl-1,2,4-triazole-3-



Antiviral, other
Infection, 



carboxamide




hepatitis-C virus


lexipafant
L-Leucine, N-methyl-N-[[4-[(2-methyl-
139133-26-9
WO
9203423
Neurological
Dementia, AIDS-



1H-imidazo[4,5-c]pyridin-1-




related



yl)methyl]phenyl]sulfonyl]-, ethyl ester-








[CAS]







LF-15-0195


WO
9624579
Immunosuppressant
Lupus 








erythematosus,








general


LF-16-0687
2-Pyrrolidinecarboxamide, N-[3-[[4-
209733-45-9
FR
2756562
Neuroprotective
Head trauma



(aminoiminomethyl)benzoyl]amino]








propyl]-l-[[2,4-dichloro-3-[[(2,4-








dimethyl-8-quinolinyl)oxy]methyl]








phenyl]sulfonyl]-, (2S)-[CAS]







LGD-1550
2,4,6-Octatrienoic acid, 7-(3,5-bis(1,1-
178600-20-9


Anticancer, other
Cancer, cervical



dimethylethyl)phenyl)-3-methyl-








(2E,4E,6E)-[CAS]







LH

9002-67-9






LH-RH

9034-40-6






liarozole
1H-Benzimidazole, 5-[(3-chlorophenyl)-
115575-11-6


Formulation, other
Psoriasis



1H-imidazol-1-ylmethyl]-[CAS]







licofelone
1H-Pyrrolizine-5-acetic acid, 6-(4-
156897-06-2


Antiarthritic, other
Arthritis, osteo



chlorophenyl)-2,3-dihydro-2,2-dimethyl-








7-phenyl-[CAS]







Licostinel

153504-81-5






lidadronate
Phosphonic acid, [1-amino-3-
63132-38-7
WO
9702827
Urological
Unspecified



(dimethylamino)propylidene]bis-[CAS]







Lidamidine

66871-56-5






lidocaine
Acetamide, 2-(diethylamino)-N-(2,6-
137-58-6


Formulation, 
Pain, post-herpetic



dimethylphenyl)-[CAS]



transdermal, patch



Lidofenin

59160-29-1






Lidoflazine

3416-26-0






limaprost
Prosta-2,13-dien-1-oic acid, 11,15-
74397-12-9
GB
2041368
Prostaglandin
Buerger's syndrome



dihydroxy-17,20-dimethyl-9-oxo-,








(2E,11Alpha,13E,15S,17S)-, [CAS]







Lincomycin

154-21-2






Lindane

58-89-9






linezolid
Acetamide, N-((3-(3-fluoro-4-(4-
165800-03-3
WO
9507271
Antibiotic, other
Infection, 



morpholinyl)phenyt)-2-oxo-5-




dermatological



oxazolidinyl)methyl)-, (S)-[CAS]







Linoleic Acid

60-33-3






Linolenic Acid

463-40-1 






Liothyronine

6893023






Lipase

9001-62-1






Lipo-
Pregna-1,4-diene-3,20-dione, 9-fluoro-
14899-36-6


Formulation, optimized,
Arthritis, 


dexamethasone
11,17-dihydroxy-16-methyl-21-[(1-



microemulsion
rheumatoid


palmitate
oxohexadecyl)oxy]-, (11β, 16Alpha)-








[CAS]







lipo-flurbiprofen
[1,1′-Biphenyl]-4-acetic acid, 2-fluoro-
91503-79-6
JP
60208910
Formulation, optimized,
Pain, cancer



Alpha-methyl-, 1-(acetyloxy)ethyl ester



microemulsion




[CAS]







Lipogel HA


EP
525655
Formulation, optimized,, 
Unspecified







liposomes



LiquiVent
perfluorooctylbromide
423-55-2
U.S.
5,437,272
Lung Surfactant
Respiratory distress








syndrome, adult


liranaftate
Garbamothioic acid, (6-methoxy-2-
88678-31-3
GB
2124617
Antifungal
Infection, 



pyridinyl)methyl-, O-(5,6,7,8-tetrahydro-




dermatological



2-naphthalenyl) ester [CAS]







lisinopril
L-Proline, 1-[N2-(1-carboxy-3-
76547-98-3
EP
12401
Antihypertensive, renin 
Hypertension, 



phenylpropyl)-L-lysyl]-, (5)-[CAS]
83915-83-7


system
general


Lisofylline

100324-81-0






lisuride
Urea, N′-[(8Alpha)-9,10-didehydro-6-
19875-60-6


Antiprolactin
Acromegaly



methylergolin-8-yl]-N,N-diethyl-, [CAS]
305-13-5








18016-80-3






Lithium Citrate

919-16-4






lithium
Carbonic acid, dilithium salt [CAS]
554-13-2


Formulation, modified-
Depression, bipolar







release <=24 hr



lixivaptan
Benzamide, N-[3-chloro-4-(5H-
168079-32-1
U.S.
5,736,540
Cardiovascular
Heart failure



pyrrolo[2,1-c][1,4]benzodiazepin-








10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-








methyl-[CAS]







LJP-1082


U.S.
6,207,160
Immunosuppressant
Thrombosia, venous


LLUAlpha
S-2,7,8-Tnmethyl-6-(l1-carboxyethyl)-6-



Antihypertensive, 
Hypertension, 



hydroxychroman



other
general


LMP-160


U.S.
5,643,893 
Antiasthma
Asthma


LMP-420


U.S.
5,643,893
Antiarthritic, other
Arthritis, 








rheumatoid


lobaplatin
Platinum, (1,2-
135558-11-1
DE
4115559
Anticancer, alkylatin




cyclobutanedimethanamine-N,N′)[2-








hydroxypropanoato(2-)-O1,O2]-, [SP-4-








3-(S),(trans)]-[CAS]







Lobeline

90-69-7






Lobenzarit

63329-53-3






lodoxamide
2,2′-((2-chloro-5-cyano-1,3-
63610-09-3
U.S.
4,439,445
Antiasthma
Asthma



phenylene)diimino)bis(2-oxoacetate):2-
53882-12-5







amino-2-(hydroxymethyl)-1,3-








propanediol (1:2) 







Lofentanil

61380-40-3






lofepramine
Ethanone, 1-(4-chlorophenyl)-2-[[3-
23047-25-8
GB
1177525
Antidepressant




(10,11-dihydro-5H-dibenz[b,f]azepin-5-
26786-32-3







yl)propyl]methylamino]-[CAS]







lofexidine
1H-Imidazole, 2-[1-(2,6-
31036-80-3
GB
1181356
Antihypertensive, 
Hypertension, 



dichlorophenoxy)ethyl]-4,5-dihydro-



adrenergic
general



[CAS]







Loflucarban

790-69-2 






lomefloxacin
3-Quinolinecarboxylic acid, 1-ethyl-6,8-
98079-51-7
EP
140116
Quinolone 
Infection, respitory 



difluoro-1,4-dihydro-7-(3-methyl-1-
98079-52-8


antibacterial
tract, lower



piperazinyl)-4-oxo-[CAS]







lomerizine
Piperazine, 1-[bis(4-
101477-54-7
EP
159566
Antimigraine
Migraine



fluorophenyl)methyl]-4-[(2,3,4-
101477-55-8







trimethoxyphenyl)methyl]-, [CAS]







lomifylline
7-(5-oxohexyl)theophylline
10226-54-7
DE
2207860
Neurological



lomustine
Urea, N-(2-chloroethyl)-N′-cyclohexyl-N-
13010-47-4
JP
48075526
Anticancer, 




nitroso-[CAS]



alkylating



lonafarnib
1-Piperidinecarboxamide, 4-[2-[4-
193275-84-2
U.S.
5,874,442
Anticancer, other
Cancer, lung, l



[(11R)-3,10-dibromo-8-chloro-6,11-




non-small cel



dihydro-5H-benzo[5,6]cyclohepta[1,2-








b]pyridin-11-yl]-1-piperidinyl]-2-








oxoethyl]-[CAS]







Lonapalene

91431-42-4






Lonazolac

53808-88-1






lonidamine
1H-Indazole-3-carboxylic acid, 1-[(2,4-
50264-69-2
DE
2310031
Radio/chemosensitizer
Cancer, breast



dichlorophenyl)methyl]-[CAS]







loperamide
4-(p-chlorophenyl)-4-hydroxy-N,N-
34552-83-5
U.S.
3,714,159
Antidiarrhoeal
Diarrhoea, general



dimethyl-Alpha,Alpha-diphenyl-1-
53179-11-6







piperidine butyramide HCl







loperamide 
1-Piperidinebutanamide, 4-(4-
106900-12-3
EP
219898
Antidiarrhoeal
Diarrhoea, general


oxide
chlorophenyl)-4-hydroxy-N,N-dimethyl-








Alpha,Alpha-diphenyl-, 1-oxide, trans-








[CAS]







loprazolam
1H-Imidazo[1,2-a][1,4]benzodiazepin-1
61197-73-7
GB
1496426
Hypnotic/Sedative




one, 6-(2-chlorophenyl)-2,4-dihydro-2-
61197-93-1







[(4-methyl-1-piperazinyl)methylene]-8-
70111-54-5







nitro-[CAS]







Loprinone

106730-54-5






loracarbef
1-Azabicyclo[4.2.0]oct-2-ene-2-
76470-66-1
EP
14475
Cephalosporin, oral
Infection, respitory 



carboxylicacid, 7-
121961-22-6



tract, lower



[(aminophenylacetyl)amino]-3-chloro-8-








oxo-, [6R-[6Alpha,7β,(R*)]]-[CAS]







Lorajmine

47562-08-3






loratadine
1-Pipendinecarboxylic acid, 4-(8-chloro
79794-75-5
EP
42544
Antiallergic, non-
Rhinitis, allergic, 



5,6-dihydro-11H-



asthma
general



benzo[5,6]cyclohepta[1,2-b]pyridin-11-








ylidene)-, ethyl ester-[CAS]







lorazepam
2H-1,4-Benzodiazepin-2-one, 7-chloro-
846-49-1


Formulation, oral, 
Epilepsy, general



5-(2-chlorophenyl)-1,3-dihydro-3-



orally-




hydroxy-



disintegrating



lorcainide
Benzeneacetamide, N-(4-chlorophenyl)
58934-46-6
DE
2642856
Antiarrhythmic




N-[1-(1-methylethyl)-4-piperidinyl]-
59729-31-6







[CAS]







lormetazepam
2H-1,4-Benzodiazepin-2-one, 7-chloro-
848-75-9
U.S.
3,296,249
Hypnotic/Sedative
Insomnia



5-(2-chlorophenyl)-1,3-dihydro-3-








hydroxy-1-methyl-[CAS]







lornoxicam
2H-Thieno[2,3-e]-1,2-thiazine-3-
70374-39-9
EP
313935
Analgesic, NSAID
Pain, post-



carboxamide, 6-chloro-4-hydroxy-2-




operative



methyl-N-2-pyridinyl-, 1,1-dioxide-








[CAS]







losartan
1H-Imidazole-5-methanol, 2-butyl-4-
124750-99-8
EP
253310
Antihypertensive, 
Hypertension, 



chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-
114798-26-4


renin system
general



biphenyl]-4-yl]methyl]-, [CAS]







loteprednol
Androsta-1,4-diene-17-carboxylic acid,
82034-46-6 
GB
2079755
Anti-inflammatory, 
Uveitis



17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-



topical




oxo-, chloromethyl ester,








(11β,17Alpha)-[CAS]







Lotrafiban

171049-14-2






Lovastatin

75330-75-5






Loxapine

10/02/1977






loxiglumide
Pentanoic acid, 4-[(3,4-
107097-80-3
WO
8703869
GI inflammatory/bowel 
Pancreatitis



dichlorobenzoyl)amino]-5-[(3-



disorders




methoxypropyl)pentylamino]-5-oxo-, (±)








[CAS]







loxoprofen
Benzeneacetic acid, Alpha-methyl-4-[(2
68767-14-6
EP
55588
Antiarthritic, other
Arthritis, 



oxocyclopentyl)methyl]-[CAS]
80382-23-6



rheumatoid




87828-36-2






Lu-35-138
1-[3[[2-[5-chloro-1-(4-fluorophenyl)-3-

WO
9516684
Neuroleptic
Psychosis, general



1H-indolyl]ethyl]methylamino]propyl]-2-








imidazolidinone hydrochloride







Lubeluzole

144665-07-6






lubiprostone
(−)-7-[(2R,4aR,5R,7aR)-2-(1,1-
136790-76-6


Laxative
Constipation



difluoropentyl)-2-hydroxy-6-








oxooctahydrocyclopenta[b]pyran-5-








yl]heptanoic acid







lucanthone
Thioxanthen-9-one, 1-((2-
479-50-5


Radio/chemosensitizer
Cancer, brain



(diethylamino)ethyl)amino-4-methyl-








[CAS]







Lucanthone

548-57-2






Lumefantrine

82186-77-4






lumiracoxib
Benzeneacetic acid, 2-((2-chloro-6-
220991-20-8


Analgesic, NSAID
Pain, general



fluorophenyl)amino)-5-methyl-[CAS]







lurtotecan
11H-1,4-Dioxino[2,3-
155773-58-3


Formulation, optimized, 
Cancer, ovarian



g]pyrano[3,4:6,7]indolizino[1,2-



liposomes




b]quinoline-9,12[8H,14H]-dione, 8-ethyl








2,3-dihydro-8-hydroxy-15-[[4-methyl-1-








piperazinyl]methyl]-, [CAS]







lutetium 
Lutetium, bis(acetato-O)[9,10-diethyl-
156436-90-7
WO
9906411
Radio/chemosensitizer
Anthersclerosis


texaphyrin
20,21-bis-[2-[2-(2-








methoxyethoxy)ethoxy]ethoxy]-4,15-








dimethyl-8,11-imino-3,6:16,13-dinitrilo-








1,18-benzodiazacycloeicosine-5,14-








dipropanolato-N1,N18,N23,N24,N25]-,








(PB-7-11-233′2′4)-[CAS]







LV-216
Zinc[2-(2,6-



Anti-inflammatory
Arthritis, 



dichloroanilino)phenyl]acetate




rheumatoid


LX-104
Hexadecanamide, N-[4-[[2-[2-[2-[[O-(N-
158792-45-1


Cognition enhancer
Dementia, senile, 



acetyl-Alpha-neuraminosyl)-(2-3)-O-β-




general



D-galactopyranosyl-(1-4)-O-[6-deoxy-








Alpha-L-galactopyranosyl-(1-3)]-β-D-








glucapyranosyl]oxy]ethoxy]ethoxy]








ethoxy]methyl]phenyl]-2-tetradecyl-








[CAS]







LY-156735
β-methyl-6-chloromelatonin

EP
655243
Hypnotic/Sedative
Sleep disorder, general


LY-293111
Benzoic acid, 2-[3-[3-[(5-ethyl-4-fluoro-
161172-51-6


Anticancer, other
Cancer, melanoma



2-hydroxy[1,1′-biphenyl]-4-








yl)oxy]propoxy]-2-propylphenoxy]-








[CAS]







LY-293558
3-Isoquinolinecarboxylic acid,
154652-83-2


Analgesic, other
Pain, neuropathic



decahydro-6-[2-(1H-tetrazol-5-yl)ethyl]-,








[3S-(3Alpha.,4aAlpha,6β,8aAlpha.)]-








[CAS]







LY-355703
1,4-Dioxa-8,11-diazacyclohexadec-13-
18256-67-7
WO
9707798
Anticancer, other
Cancer, lung, 



ene-2,5,9,12-tetrone, 10-[(3-chloro-4-




non-small cell



methoxyphenyl)methyl]-6,6-dimethyl-3-








(2-methylpropyl)-16-[(1S)-1-[(2S,3R)-3-








phenyloxiranyl]ethyl]-,








(3S,10R,13E,16S)-[CAS]







Lyapolate

25053-27-4






Lymecycline

992-21-2






Lynestrenol

52-76-6






Lypressin

50-57-7






Lysine 

62952-06-1






Acetylsalicylate








lysine salicylate
L-Lysine, 2-hydroxybenzoate [CAS]
59535-08-9
WO
9624331
Analgesic, NSAID



lysophos-


WO
9843093
Diagnostic
Diagnosis, cancer


pholipids








M-40403
Dichloro[(4aR,13aR,17aR,21aR)-

U.S.
6,180,620
Anticancer, other
Unspecified



1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,








17a,18,19,20,21,21a-eicosahydro-1,7-








nitrilo-7H-dibenzo[b,h]








[1,4,7,10]tetraazacyclo-heptadecine-








kappaN5,kappaN13,kappaN18,kappaN








21,kappaN22]manganese







mabuprofen
Benzeneacetamide, N-(2-hydroxyethyl)
82821-47-4
DE
3121595
Anti-inflammatory




Alpha-methyl-4-(2-methylpropyl)-, (+/−)-








[CAS]







Mabuterol

56341-08-3






Macrophage 

81627-83-0






Colony-








Stimulating 








Factor








MADU

840-50-6






mafenide
Benzenesulfonamide, 4-(aminomethyl)-
13009-99-9


Vulnerary
Burns



monoacetate [CAS]
138-39-6






mafosfamide
Ethanesulfonic acid, 2-[[2-[bis(2-
88859-04-5
EP
393575
Anticancer, alkylating
Cancer, renal



chloroethyl)amino]tetrahydro-2H-1,3,2-
98845-64-8







oxazaphosphorin-4-yl]thio]-, P-oxide,








cis-(±)-[CAS]







magaldrate
Aluminum magnesium hydroxide
74978-16-8
U.S.
2,923,660
Antacid/Antiflatulent




sulfate (Al5Mg10(OH)31(SO4)2),








hydrate [CAS]







Magenta I

632-99-5






Magnesium 

132-49-0






Acetylsalicylate








Magnesium 

39409-82-0






Carbonate








Hydroxide








magnesium 
Magnesium chloride (MgCl2) [CAS]
7786-30-3


Formulation, oral, 
Nutrition


chloride




enteric-coated



Magnesium 

3344-18-1






Citrate








magnesium 
D-Gluconic acid, magnesium salt (2:1)
3632-91-5


Formulation, other
Hypertension, 


gluconate
[CAS]




general


Magnesium 

18917-93-6






Lactate








Magnesium 

18917-89-0






Salicylate








Malathion

121-75-5






Malotilate

59937-28-9






Mandelic 

90-64-2






Acid








Mandelic 

5421045






Acid Isoamyl 








Ester








Mangafodipir

118248-94-5








(free acid);








155319-91-8








(hexahydrogen)






manidipine
3,5-Pyridinedicarboxylic acid, 1,4-
89226-50-6
EP
94159
Antihypertensive, 
Hypertension, 



dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,
89226-75-5


other
general



2-[4-(diphenylmethyl)-1-








piperazinyl]ethyl methyl ester [CAS]







Mannomustine

551-74-6






mannose-6-
mannose-6-phosphate



Vulnerary
Wound healing


phosphate








Maprotiline

10262-69-8






maribavir
1H-Benzimidazol-2-amine, 5,6-dichloro
176161-24-3


Antiviral, other
Cancer, pancreatic



N-(1-methylethyl)-1-β-L-ribofuranosyl-








[CAS]







marimastat
N-[2,2-Dimethyl-1(S)-(N-
154039-60-8
WO
9402447
Anticancer, other
Cancer, pancreatic



methylcarbamoyl)propyl]-N,3(S)-








dihydroxy-2(R)-isobutytsuccinamide







maxacalcitol
1,3-Cyclohexanediol, 4-methylene-5-(2
103909-75-7
U.S.
4,891,364
Hormone
Hyperarathyroidism



(octahydro-1-(1-(3-hydroxy-3-








methylbutoxy)ethyl)-7a-methyl-4H-








inden-4-ylidene)ethylidene)-, (1S-








(1Alpha(R*),3aβ,4E(1S*,3R*,5Z),








7aAlpha))-[CAS]







mazindol
3H-Imidazo[2,1-a]isoindol-5-ol, 5-(4-
22232-71-9
U.S.
3,763,178
Anorectic/Antiobesity
Obesity



chlorophenyl)-2,5-dihydro-[CAS]







Mazipredone

13085-08-0 






MC-5723


U.S.
6,043,259
Cardiovascular
Unspecified


MCC-478
(2-amino-6-(4-methoxyphenylthio)-9-



Antiviral, other
Infection, 



[2-(phosphonomethoxy)ethyl]purine




hepatitis-B virus



bis(2,2,2-trifluoroethyl) ester)







MCI-154
3(2H)-Pyridazinone, 4,5-dihydro-6-
98326-32-0
EP
145019
Cardiostimulant
Heart failure



[4-(4-pyridinylamino)phenyl]-,
98326-33-1







monohydrochioride [CAS]







m-Cresyl 

122-46-3 






Acetate








MDAM
Gamma-Methylene-10-



Anticancer, 
Cancer, general



deazaaminopterin



antimetabolite



MDI-101


U.S.
4,885,311
Antiacne
Acne


MDI-403

403849-94-5
U.S.
4,677,120
Antiacne
Acne


MDL-100907
4-Piperidinemethanol, Alpha-(2,3-
139290-65-6


Hypnotic/Sedative
Sleep disorder, 



dimethoxyphenyl)-1-(2-(4-




general



fluorophenyl)ethyl)-, (R)-[CAS]







mebendazole
methyl-5-benzoylbenzimidazole-2-
31431-39-7
GB
1307306
Anthelmintic




carbamate







mebeverine
Benzoic acid, 3,4-dimethoxy-, 4-
3625-06-7


Antispasmodic
Irritable bowel 



[ethyl[2-(4-methoxyphenyl)-1-




syndrome



methylethyl]amino]butyl ester [CAS]







Mebhydroline

524-81-2






Mebrofenin

78266-06-5






Mebutamate

64-55-1






mecamylamine
Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-
60-40-2


Neurological
Unspecified



tetramethyl-[CAS]







Mechloreth-

51-75-2






amine








Mechloreth- 

302-70-5






amine Oxide








mecillinam
4-Thia-1-azabicyclo[3.2.0]heptane-2-
32887-01-7
GB
1293590
Penicillin, injectable
Infection, general



carboxylic acid, 6-[[(hexahydro-1H-
32887-03-9







azepin-1-yl)methylene]amino]-3,3-








dimethyl-7-oxo-, [2S-








(2Alpha,5Alpha,6.beta.)]-[CAS]







Meclizine

569-65-3






Meclocycline

2013-58-3






meclofenamate
Benzoic acid, 2-[(2,6-dichloro-3-
6385-02-0


Antiarthritic, other
Arthritis, osteo



methylphenyl)amino]-, monosodium
644-62-2







salt [CAS]







Meclofenamic 

644-62-2






Acid








Meclofenoxate

51-68-3






Mecloqualone

340-57-8






Mecysteine

18598-63-5






Medazepam

12/06/2898 

















medifoxamine
Ethanamine, N,N-dimethyl-2,2-
32359-34-5
FR
M5498
Antidepressant















diphenoxy-[CAS]







Medrogestone

977-79-7






Medronic Acid

1984-15-2






medroxypro-
Pregn-4-ene-3,20-dione, 17-(acetytoxy)
71-58-9


Formulation, fixed-
Contraceptive, 


gesterone
6-methyl-,(6Alpha)
520-85-4


dose combinations
female


Medrysone

2668-66-8






Mefenamic 

61-68-7






Acid








Mefenorex

17243-57-1






Mefexamide

1227-61-8






mefloquine
4-Quinolinemethanol, Alpha-2- 
51773-92-3
GB
1594282
Antimalarial




piperidinyl-2,8-bis(trifluoromethyl)-,
53230-10-7







(R*,S*)-(±)-[CAS]
69191-18-0






Mefruside

7195-27-9






Megestrol

595-33-5






Meglumine

22154-43-4








131-49-7






meglutol
2-hydroxy-2-methyl-,3-
503-49-1
U.S.
3,629,449
Hypolipaemic/
Hyperlipidaemia, 



propandicarboxylic acid



Antiatherosclerosis
general


melagatran
Glycine, N-[(1R)-2-[(2S)-2-[[[[4-
159776-70-2
WO
9616671
Antithrombotic
Thrombosis, 



(aminoiminomethyl)phenyl]methyl]




general



amino]carbonyl]-1-azetidinyl]-1-








cyclohexyl-2-oxoethyl]-[CAS]







melano-
N-[(3R)-1,2,3,4-



Anorectic/Antiobesity
Obesity


cortin-4 
Tetrahydroisoquinolinium-3-ylcarbonyl]-







agonist
(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-








4-(1H-1,2,4-triazol-1-ylmethyl)piperidin-








1-yl]-2-oxoethylamine(1)







Melarsoprol

494-79-1






Melengestrol

5633-18-1






melevodopa
Alanine, 3-(3,4-dihydroxyphenyl)-
7101-51-1
EP
252290
Antiparkinsonian
Parkinson's disease



methylester [CAS]







Melinamide

14417-88-0






Melitracen

5118-29-6






meloxicam
2H-1,2-Benzothiazine-3-carboxamide,
71125-38-7
U.S.
4,233,299
Antiarthritic, other
Arthritis, 



4-hydroxy-2-methyl-N-(5-methyl-2-




rheumatoid



thiazolyl)-, 1,1-dioxide-[CAS]







melperone
1-Butanone, 1-(4-fluorophenyl)-4-(4-
1622-79-3
BE
651144
Neuroleptic




methyl-1-piperidinyl)-[CAS]
3575-80-2






Metphalan

148-82-3






meluadrine
Benzenemethanol, 2-chloro-Alpha-
134865-37-5
EP
420120
Labour inhibitor
Labour, preterm



(((1,1-dimethylethyl)amino)methyl)-4-








hydroxy-, (R)-, (R*,R*))-2,3-








dihydroxybutanedjoate (1:1) (salt)








[CAS]







memantine
Tricyclo[3.3.1.13,7]decan-1-amine, 3,5-
41100-52-1
EP
392059
Cognition enhancer
Dementia, AIDS-



dimethyl [CAS]
19982-08-2



related


MEN-10700
Acetamide, 2-[[[(5R,6S)-6-[(1R)-1-
195874-55-6
WO
9406803
Beta-lactam antibiotic
Infection, general



hydroxyethyl]-2-methyl-7-oxo-4-thia-1-








azabicyclo[3.2.0]hept-2-en-3-








yl]methyl]methylamino]-[CAS]







MEN-10755
5,12-Naphthacenedione, 7-[[4-O-(3-
169317-77-5
WO
9509173
Anticancer, antibiotic
Cancer, breast



amino-2,3,6-trideoxy-Alpha-L-lyxo-








hexopyranosyl)-2,6-dideoxy-Alpha-L-








lyxo-hexopyranosyl]oxy]-7,8,9,10-








tetrahydro-6,9,11-trihydroxy-9-








(hydroxyacetyl)-, hydrochloride,








(7S,9S)-[CAS]







Menadiol

481-85-6






Menadione

58-27-5






Menadoxime

573-01-3






Menbutone

3562-99-0






Menogaril

71628-96-1






MENT
7Alpha-Methyl-19-nortestosterone



Formulation, 
Contraceptive, 







transdermal, 
male







systemic



menthol
Cyclohexanol, 5-methyl-2-(1-
1490-04-6


Formulation, dermal, 
Puritus



methlethyl)-[CAS]
89-78-1


topical



Menthyl 

89-47-4






Valerate








Meobentine

46464-11-3






Meparfynol

77-75-8






mepartncin
Partricin, methyl ester [CAS]
11121-32-7
U.S.
3,780,173
Antifungal
Infection, Candida, 








general


Mepazine

60-89-9






Mepenzolate 

76-90-4






Bromide








Meperidine

57-42-1






Mephenesin

59-47-2






Mephenoxalone

70-07-5






Mephentermine

100-92-5






Mephenytoin

50-12-4






Mephobarbital

115-38-8






Mepindolol

23694-81-7






Mepitiostane

21362-69-6






mepivacaine
N-(2,6-Dimethylphenyl)-1-methyl-2-
96-88-8


Formulation, modified-
Pain, post-



piperidinecarboxamide



release, >24 hr
operative


Mepixanox

17854-59-0






Meprednisone

1247-42-3






Meprobamate

57-53-4






meproscillarin
Bufa-4,20,22-trienolide, 3-[(6-deoxy-4-
33396-37-1
DE
1910207
Cardiostimulant
Heart failure



O-methyl-Alpha-L-








mannopyranosyl)oxy]-14-hydroxy-, (3β)








[CAS]







meptazinol
Phenol, 3-(3-ethylhexahydro-1-methyl-
54340-58-8
GB
1285025
Analgesic, other
Pain, general



1H-azepin-3-yl)-[CAS]
59263-76-2






mequitazine
10H-Phenothiazine, 10-(1-
29216-28-2
GB
1250534
Antiallergic, non-




azabicyclo[2.2.2]oct-3-ylmethyl)-[CAS]



asthma



Meralein

4386-35-0






Meralluride

8069-64-5






Merbromin

129-16-8






Mercaptomerin

21259-76-7






Mercumallylic 

86-36-2






Acid








Mercuric 

10124-48-8






Chloride,








Ammoniated








Mercuric 

1191-80-6






Oleate








Mercuric 

1335-31-5






Oxycyanide








merimepodib
Carbamic acid, ((3-((((3-methoxy-4-(5-
198821-22-6
U.S.
5,807,876
Antiviral, other
Infection, 



oxazolyl)phenyl)amino)carbonyl)amino)




hepatitis-C virus



phenyl)methyl)-(3S)-tetrahydro-3-








furanyl ester [CAS]







meropenem
1-Azabicyclo[3.2.0]hept-2-ene-2-
96036-03-2
EP
126587
Beta-lactam antibiotic
Infection, respiratory 



carboxylic acid, 3-[[5-




tract, lower



[(dimethylamino)carbonyl]-3-








pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-








methyl-7-oxo-, [4R-








[3(3S*,5S*),4Alpha,5β,6β(R*)]]-[CAS]







Mersalyl

492-18-2






Mesalamine

89-57-6






mesalazine
Benzoic acid, 5-amino-2-hydroxy-
89-57-6
WO
5541170 
Formulation, oral, 
Colitis, ulcerative



[CAS]



other



Mesna

19767-45-4






Mesoridazine

5588-33-0






Mestanolone

521-11-9






Mesterolone

1424-00-6






Mestranol

72-33-3






Mesulfen

135-58-0






Metaclazepam

84031-17-4






Metampicillin

6489-97-0






Metapramine

21730-16-5






Metaproterenol

586-06-1






Metaraminol

54-49-9






Metazocine

3734-52-9






metergoline
Carbamic acid, [[(8β)-1,6-
17692-51-2
GB
1401935
Antiprolactin
Amenorrhoea



dimethylergolin-8-yl]methyl]-,
21631-37-8







phenylmethyl ester [CAS]
2706-42-5






metformin
Imidodicarbonimidic diamide, N,N-
657-24-9


Formulation, modified-
Diabetes, Type II



dimethyl-[CAS]



release, <=24 hr



Methacholine

62-51-1






Methacycline

914-00-1






Methadone

76-99-3






Methafurylene

531-06-6






Metham-

537-46-2






phetamine








Methandriol

52 1-10-8






Methandro-

72-63-9






stenolone








Methantheline

53-46-3






Methapyrilene

91-80-5






Methaqualone

72-44-6






Metharbital

50-11-3






Methazolamide

554-57-4






Methdilazine

1982-37-2






Methenamine

100-97-0






Methenolone

153-00-4






Methestrol

130-73-4






Methetoin

5696-06-0






Methicillin

132-92-3






Methimazole

60-56-0






Methiodal

126-31-8






Methionic 

503-40-2






Acid








Methionine

63-68-3






Methisazone

1910-68-5






Methitural

467-43-6 






Methixene

02/02/4969






Methocarbamol

532-03-6






Methohexital

22151-68-4






methotrexate
L-Glutamic acid, N-[4-[[(2,4-diamino-6-
59-05-2
U.S.
2,512,572
Anticancer, 
Cancer, general



ptendinyl)methyl]methylamino]benzoyl]-



anmetabolite




[CAS]







Methotn-

60-99-1






meprazine








Methoxamine

390-28-3






Methoxsalen

298-81-7






Methoxy-

76-38-0






flurane








Methoxy-

93-30-1






phenamine








Methoxy-

61-01-8






promazine








Methsco-

155-41-9






polamine








Methsuximide

77-41-8






Methy-

135-07-9






clothiazide








Methyl Blue

28983-56-4






Methyl 

93-60-7 






Nicotinate








Methyl Propyl 

557-17-5






Ether








Methyl 

119-36-8






Salicylate








Methyl tert-

1634-04-4 






Butyl Ether








Methyl-

25155-18-4






benzethonium 








Chloride








Methylcobalamin

13422-55-4






methyldopa
L-Tyrosine, 3-hydroxy-Alpha-methyl-
555-30-6


Formulation, modified-
Hypertension, 



[CAS]



release, <=24 hr
general


Methylene Blue

61-73-4






Methyl-
113-42-8







ergonovine








Methyl-

105-41-9






hexaneamine








methylphenidate
2-Piperidineacetic acid, Alpha-phenyl-,
113-45-1


Formulation, modified-
Attention deficit 



methyl ester [CAS]
298-59-9


release, multi
disorder


Methyl-

83-43-2






prednisolone








methyl-
Pregna-1,4-diene-3,20-dione, 21-
86401-95-8
EP
72547
Antipruritic/inflamm, 
Pruritus


prednisolone
(acetyloxy)-11-hydroxy-6-methyl-17-(1-



allergic



aceponate
oxopropoxy)-, (6Alpha,11β)-[CAS]







methyl-
Pregna-1,4-diene-3,20-dione, 11,17-
90350-40-6
JP
59137500
Antiasthma
Asthma


prednisolone
dihydroxy-6-methyl-21-[[8-[methyl(2-







suleptanate
sulfoethyl)amino]-1,8-dioxooctylloxy]-,








monosodium salt, (6Alpha,11β)-[CAS]







Methylthiouracil

56-04-2






Methyltrienolone

965-93-5






Methyprylon

125-64-4






Methysergide

361-37-5






Metiazinic Acid

13993-65-2






metipranolol
Phenol, 4-[2-hydroxy-3-[(1-
22664-55-7
GB
1206148
Antihypertensive, 




methylethyl)amino]propoxy]-2,3,6-



adrenergic




trimethyl-, 1-acetate [CAS]







metoclopramide
Benzamide, 4-amino-5-chloro-N-[2-
364-62-5


Formulation, modified-
Gastro-oesophageal 



(diethylamino)ethyl]-2-methoxy-[CAS]



release, <=24 hr
reflux


Metocurine 

7601-55-0






Iodide








Metofenazate

388-51-2






metolazone
6-Quinazolinesulfonamide, 7-chloro-
17560-51-9
U.S.
4,517,179
Antihypertensive, 




1,2,3,4-tetrahydro-2-methyl-3-(2-



diuretic




methylphenyl)-4-oxo-[CAS]







Metopimazine

14008-44-7






Metopon

143-52-2






metoprolol
2-Propanol, 1-[4-(2-
51384-51-1


Formulation, modified-
Hypertension, general



methoxyethyl)phenoxy]-3-[(1-
56392-17-7


release, other




methylethyl)amino]-, (+/−)-[CAS]
37350-58-6






Metralindole

54188-38-4






Metnzamide

31112-62-6






Metrizoic 

1949-45-7 






Acid








Metron S

13946-02-6






Metyrapone

54-36-4






Metyrosine

672-87-7






Mexazolam

31868-18-5






Mexenone

1641-17-4






Mexiletine

31828-71-4






mezlocillin
4-Thia-1-azabicyclo[3.2.0]heptane-2-
42057-22-7
GB
1301961
Penicillin, injectable
Infection, general



carboxylic acid, 3,3-dimethyl-6-[[[[[3-
51481-65-3







(methylsulfonyl)-2-oxo-1-
72539-76-5







imidazolidinyl]carbonyl]amino]








phenylacetyl]amino]-7-oxo-, [2S-








[2Alpha,5Alpha,6β(S*)]]-[CAS]







MFH-244
Benzenecarboximidic acid, 3,4,5-
95933-76-9
U.S.
4,623,659
Cardiovascular
Reperfusion injury



trihydroxy-, ethyl ester, hydrochloride







mianserin
Dibenzo[c,f]pyrazino[1,2-a]azepine,
21535-47-7
GB
1173783 
Antidepressant
Depression, general



1,2,3,4,10,14b-hexahydro-2-methyl-
242 19-97-4







[CAS]







Mibefradil

116644-53-2






Miboplatin

103775-75-3






Micafungin

235114-32-6






miconazole
1H-Imidazole,1-(2,4-dichlorophenyl)-
22916-47-8


Formulation, modified-
Infection, Candida, 



2[2,4-dichlorophenyl)methoxy]ethyl]



release, other
general


Micronomicin

52093-21-7






midaxifylline
1H-Purine-2,6-dione, 8-(1-
151159-23-8
U.S.
5,378,844
Cardiovascular
Unspecified



aminocyclopentyl)-3,7-dihydro-1,3-








dipropyl-[CAS]







midazolam
4H-Imidazo[1,5-a][1,4]benzodiazepine,
59467-70-8
U.S.
4,280,957
Anaesthetic, 




8-chloro-6-(2-fluorophenyl)-1-methyl-
59467-94-6


injectable




[CAS]







midecamycin
Leucomycin V, 3,4B-dipropanoate
35457-80-8
U.S.
3,761,588
Macrolide antibiotic
Infection, general



[CAS]







midecamycin 
Leucomycin V, 3B,9-diacetate 3,4B-
55881-07-7
JP
49124087
Macrolide antibiotic
Infection, general


acetate
dipropanoate [CAS]







midesteine
2-Thiophenecarbothioic acid, S-[1-
94149-41-4
EP
120534
COPD treatment
Emphysema, general



methyl-2-oxo-2-[(tetrahydro-2-oxo-3-








thienyl)amino]ethyl] ester [CAS]







midodrine
Acetamide, 2-amino-N-[2-(2,5-
42318-56-0
EP
164571
Urological
Incontinence



dimethoxyphenyl)-2-hydroxyethyl]-
42794-76-3







[CAS]







midostaurin
Benzamide, N-(2,3,10,11,12,13-
120685-11-2
EP
296110
Anticancer, other
Cancer, leukaemia, 



hexahydro-10-methoxy-9-methyl-1-oxo




acute myelogenous



9,13-epoxy-1H,9H-diindolo[1.2,3-








gh:3′,2′,1′-Im]pyrrolo[3,4-








j][1,7lbenzodiazonin-11-yl)-N-methyl-,








(9Alpha,10β,11β,13Alpha)-[CAS]







mifepristone
Estra-4,9-dien-3-one, 11-[4-
84371-65-3
EP
57115
Abortifacient
Abortion



(dimethylamino)phenyl]-17-hydroxy-17-








(1-propynyl)-, (11β,17β)-[CAS]







miglitol
3,4,5-Piperidinetnol, 1-(2-hydroxyethyl)-
72432-03-2
EP
55431
Antidiabetic
Diabetes, Type I



2-(hydroxymethyl)-, [2R-








(2Alpha,3β,4Alpha,5β)]-[CAS]







miglustat
3,4,5-Piperidinetriol, 1-butyl-2-
72599-27-0
DE
2758025
Metabolic and enzyme 
Gaucher's disease



(hydroxymethyl)-(2R-(2Alpha, 3B,



disorders




4Alpha, 5β)) [CAS]







mildronate
Hydrazinium, 2-(2-carboxyethyl)-1,1,1-
76144-81-5
WO
8001068
Cardiostimulant
Heart failure



trimethyl-, inner salt-[CAS]







milnacipran
Cyclopropanecarboxamide, 2-
101152-94-7
U.S.
4,478,836
Antidepressant
Depression, general



(aminomethyl)-N,N-diethyl-1-phenyl-,
92623-85-3







cis-(±)-[CAS]







Miloxacin

37065-29-5






milrinone
[3,4′-Bipyridine]-5-carbonitrile, 1,6-
78415-72-2
U.S.
4,313,951
Cardiostimulant
Heart failure



dihydro-2-methyl-6-oxo-[CAS]







miltefosine
Ethanaminium, 2-








[[(hexadecyloxy)hydroxyphosphinyl]oxy]
53949-20-5
EP
225608
Anticancer, other
Cancer, skin, general



N,N,N-trimethyl-, hydroxide, inner salt
58066-85-6







[CAS]







minaprine
4-Morpholineethanamine, N-(4-methyl- 
25905-77-5
GB
1345880
Antidepressant
Depression, general



6-phenyl-3-pyridazinyl)-[CAS]
25953-17-7






minocycline
2-Naphthacenecarboxamide, 4,7-
10118-90-8


Formulation, optimized,
Infection, oral



bis(dimethylamino)-



microparticles




1,4,4a,5,5a,6,11,12a-octahydro-








3,10,12,12a-tetrahydroxy-1,11-dioxo-,








[4S-








(4Alpha,4aAlpha,5a.alpha.,12aAlpha)]-








[CAS]







minodronic 
Phosphonic acid, (1-hydroxy-2-
180064-38-4
EP
354806
Anticancer, other
Cancer, myeloma


acid
imidazo(1,2-a)pyridin-3-ylethylidene)bis-,








[CAS]







minoxidil
2,4-Pyrimidinediamine, 6-(1-piperidinyl)-,
38304-91-5
U.S.
4,139,619
Vasodilator, 
Hypertension, general



3-oxide [CAS]



peripheral



Miokamycin

55881-07-7






mirtazapine
Pyrazino[2,1-a] pyrido[2,3-
85650-52-8
GB
1543171
Antidepressant
Depression, general



c][2]benzazepine,1,2,3,4,10,14b-
61337-67-5







hexahydro-2-methyl-[CAS]







misoprostol
Prost-13-en-1-oic acid, 11,16-dihydro
59122-46-2
U.S.
4,301,146
Prostaglandin
Ulcer, gastric



16-methyl-9-oxo-, methyl ester,
59122-48-4







(11Alpha,13E)-(±)-[CAS]







mitemcinal
Erythromycin, 8,9-didehydro-N-
154802-96-7
WO
9324509
Gastroprokinetic
Gastro-oesophageal 



demethyl-9-deoxo-6,11-dideoxy-6,9-




reflux



epoxy-12-O-methyl-N-(1-methylethyl)-








11-oxo-, (2E)-2-butenedioate (2:1)








[CAS]







mitigilnide
Calcium (2S)-2-benzyl-3-(cis-
145525-41-3
EP
507534
Antidiabetic
Diabetes, Type II



hexahydro-2-








isoindolinylcarbonyl)propionate,








dihydrate-[CAS]







Mitobronitol

488-41-5






Mitoguazone

459-86-9






mitolactol
Galactitol, 1,6-dibromo-1,6-dideoxy-
10318-26-0
U.S.
3,993,781
Anticancer, alkylating
Cancer, cervical



[CAS]







mitomycin
Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-
50-07-7


Formulation, 
Cancer, stomach



dione, 6-amino-8-



parenteral, other




[[(aminocarbonyl)oxy]methyl]-








1,1a,2,8,8a,8b-hexahydro-8a-methoxy-








5-methyl-, [1aS-








(1aAlpha,8β,8aAlpha,8bAlpha)]-[CAS]







Mitotane

53-19-0






mito-
9,10-Anthracenedione, 1,4-dihydroxy-
65271-80-9
U.S.
4,197,249
Anticancer, other
Cancer, breast


xantrone
5,8-bis[[2-[(2-
70476-82-3







hydroxyethyl)amino]ethyl]amino]-








[CAS]







mito-
9,10-Anthracenedione, 1,4-dihydroxy-
65271-80-9


Formulation, 
Cancer, general


xantrone
5,8-bis[[2-[(2-
70476-82-9


optimized, 




hydroxyethyl)amino]ethyl]amino]-



liposomes




[CAS]







MIV-210
(3-Fluoro-2′-3′-dideoxy guanosine)



Antiviral, other
Infection, 








hepatitis-B virus


mivacurium
Isoquinolinium, 2,2′-[(1,8-dioxo-4-
106861-44-3
EP
181055
Muscle relaxant
Anaesthesia, 



octene-1,8-diyl)bis(oxy-3,1-




adjunct



propanediyl)]bis[1,2,3,4-tetrahydro-6,7-








dimethoxy-2-methyl-1-[(3,4,5-








trimethoxyphenyl)methyl]-, dichloride,








[R-[R*,R*-(E)]]]-[CAS]







Mivazerol

125472-02-8






mizolastine
4(1H)-Pyrimidinone, 2-[[1-[1-[(4-
108612-45-9
EP 
217700 
Antiallergic, non-
Rhinitis, allergic, 



fluorophenyl)methyl]-1H-benzimidazol



asthma
general



2-yl]-4-piperidinyl]methylamino]-[CAS]







Mizoribine

50924-49-7






MKC-733
(R)-N-(3-quinuclidinyl)-7-oxo-4,7-
194093-42-0
JP
09216888
Gastroprokinetic
Gastro-oesophageal 



dihydrothieno[3,2-b]pyridine-6-




reflux



carboxamide hydrochloride







MLN-519
6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-
211866-70-5
WO
9915183
Neuroprotective
Ischaemia, cerebral



dione, 1-[(1S)-1-hydroxy-2-








methylpropyl]-4-propyl-, (1R,4R,5S)-








[CAS]







MLN.576
4-Methoxy-benzo[a]phenazine-11-



Anticancer, other
Cancer, general



carboxylic acid (2-(dimethylamino)-1-








(R)-methylethyl)-amide







moclobemide
Benzamide, 4-chloro-N-[2-(4-
71320-77-9
EP
326023
Antidepressant
Depression, general



morpholinyl)ethyl]-[CAS]







modafinil
Acetamide, 2-[(diphenylmethyl)sulfinyl]-
68693-11-8
DE
2809625
Psychostimulant
Narcolepsy



[CAS]







moexipril
3-Isoquinolinecarboxylic acid, 2-[2-[[1-
103775-10-6
U.S.
4,344,949
Antihypertensive, renin 
Hypertension, 



(ethoxycarbonyl)-3-phenylpropyl]amino]
103775-14-0


system
general



1-oxopropyl]-1,2,3,4-tetrahydro-6,7-








dimethoxy- (3S-(2(R*(R*)),3R*))-[CAS]







Mofarotene

125533-88-2






Mofebutazone

2210-63-1






Mofegiline

119386-96-8






mofezolac
5-Isoxazoleacetic acid, 3,4-bis(4-
78967-07-4
EP
26928
Analgesic, NSAID
Pain, post-operative



methoxyphenyl)-[CAS]







MOL-6131
N-[4-(aminomethyl)benzyl]-8(S)-[1-[4-[2



Antiasthma
Asthma



(4-aminophenyl)-








acetamido]butyryl]piperidin-4-yl]-2-








(naphthalen-1-ylmethyl)-1,3-dioxo-








2,3,5,8-tetrahydro-1H-








[1,2,4]triazolo[1,2-a]-pyridazine-5(R)-








carboxamide







Molindone

7416-34-4






molsidomine
Sydnone imine, N-(ethoxycarbonyl)-3-
25717-80-0
U.S.
3,769,283
Vasodilator, coronary




(4-morpholinyl)-[CAS]







mometasone
Pregna-1,4-diene-3,20-dione, 9,21-
105102-22-5
EP
57401
Antipruritic/inflamm, 
Psoriasis



dichloro-11,17-dihydroxy-16-methyl-,
83919-23-7


allergic




(11β,16Alpha)-[CAS]







Monatepil

103377-41-9






Monobenzone

103-16-2






monolaurin
Dodecanoic acid, monoester with 1,2,3-
27215-38-9
U.S.
4,885,282
Dermatological
Ichthyosis



propanetriol [CAS]







montelukast
Cyclopropaneacetic acid, 1-[[[1-[3-[2-(7
151767-02-1


Antiasthma
Asthma



Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2
158966-92-8







(1-hydroxy-l-








methylethyl)phenyl]propyl]thio]methyl]-,








[CAS]







Monteplase

122007-85-6






Moperone

1050-79-9






Mopidamol

13665-88-8






Moprolol

5741-22-0






moracizine
Carbamic acid, [10-[3-(4-morpholinyl)-1
29560-58-5
U.S.
3,864,487
Antiarrhythmic
Tachycardia, 



oxopropyl]-10H-phenothiazin-2-yl]-,
31883-05-3



ventricular



ethyl ester [CAS]







Morazone

6536-18-1






Moricizine

31883-05-3






Moroxydine

3731-59-7






Morphazin-

952-54-5






amide








morphine
Morphinan-3,6-diol, 7,8-didehydro-4,5-
57-27-2


Formulation, 
Pain, cancer



epoxy-17-methyl- (5Alpha,6Alpha)-,
6055-06-7


parenteral, other




[CAS]
64-31-3






morphine-6-
morphine-6-glucuronide



Formulation, 
Pain, general


glucuronide




inhalable, systemic



mosapramine
Spiro[imidazo[1,2-a]pyridine-3(2H),4′-
89419-40-9
U.S.
4,337,260
Neuroleptic




piperidin]-2-one, 1′-[3-(3-chloro-10,11-
98043-60-8







dihydro-5H-dibenz[b,f]azepin-5-








yl)propyl]hexahydro-, (+/−)-[CAS]







mosapride
Benzamide, 4-amino-5-chloro-2-ethoxy
112885-41-3
EP
243959
GI inflammatory/bowel 
Gastritis



N-((4-((4-fluorophenyl)methyl)-2-
112885-42-4


disorders




morpholinyl)methyl)-[CAS]







motexafin 
Gadolinium, bis(acetetato-
246252-06-2


Radio/chemosensitizer
Cancer, brain


gadolinium
kappaO)(9,10-diethyl-20,21-bis(2-(2-(2-








methoxy)ethoxy)ethoxy)-4,15-dimethyl-








8,11-imino-3,16:16,13-dinitrilo-1,18-








benzodiazacycloeicosine-5,14-








dipropanalato-kappaN1, kappaN18,








kappaN23, kappaN24, kappaN25), (PB-








7-11-233′2′4) [CAS]







Motretinide

56281-36-8






Moveitipril

85856-54-8






Moxalactam

64952-97-2






Moxastine

3572-74-5






Moxaverine

10539-19-2






Moxestrol

34816-55-2






moxifloxacin
3-Quinolinecarboxylic acid, 1-
186826-86-8
DE 
19546249 
Quinolone 
Infection, respiratory 



cyclopropyl-6-fluoro-1,4-dihydro-8-
151096-09-2


antibacterial
tract, general



methoxy-7-(octahydro-6H-pyrrolo(3,4-








b)pyridin-6-yl)-4-oxo-, hydrochloride 








(4aS-cis)-[CAS]







moxisylyte
Phenol, 4-[2-(dimethylamino)ethoxy]-2-
964-52-3


Male sexual 
Impotence



methyl-5-(1-methylethyl)-, acetate
54-32-0


dysfunction




(ester), [CAS]







moxonidine
5-Pyrimidinamine, 4-chloro-N-(4,5-
75438-57-2
DE
2849537
Antihypertensive, other
Hypertension, 



dihydro-1H-imidazol-2-yl)-6-methoxy-2-




general



methyl-[CAS]







M-PGA
(−)-(S)-2-Methyl-2-(1-oxo-2,3-dihydro-

U.S.
5,712,291
Anticancer, other
Cancer, general



1H-isoindol-2-yl)pentanedioic acid







MPI-5010
Platinum diamminedichloro-, (SP-4-2) +

U.S.
6,224,883
Formulation, parenteral, 
Cancer, head and 



(R)-4-[1-hydroxy-2-(methylamino)-



other
neck



ethyl]-1,2-benzenediol







MPI-5020
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
51-21-8
U.S.
5,750,146
Formulation, parenteral, 
Cancer, breast



[CAS]



other



MPL

198076-81-2


Immunostimulant, other
Vaccine adjunct


MRS-1754


U.S.
6,060,481
Antiasthma
Asthma


MS-209
1-Piperazineethanol, 4-(diphenylacetyl)
158681-49-3


Radio/chemosensitizer
Cancer, breast



Alpha-[(5-quinolinyloxy)methyl]-, (2E)-2








butenedioate(2:3) (salt) [CAS]







MS-275
N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-



Anticancer, 
Cancer, lung, general



methoxycarbonyl)aminomethyl]benz-



antimetabolite




amide







MS-325

201688-00-8






MS-377


EP
839805 
Neuroleptic
Schizophrenia


Mupirocin

12650-69-0






Muscarine

300-54-9






Muzolimine

55294-15-0






MX-101 3


U.S.
6,153,591
Hepatoprotective
Unspecified


myco-
4-Hexenoic acid, 6-(1,3-dihydro-4-
116680-01-4
WO
9119498
Immunosuppressant
Transplant rejection, 


phenolate 
hydroxy-6-methoxy-7-methyl-3-oxo-5-
128794-94-5



general


mofetil
isobenzofuranyl)-4-methyt-, 2-(4-








morpholinyl)ethyl ester, (E)-[CAS]







myco-
4-hexanoic acid, 6-(1,3-dihydro-4-
37415-62-6


Formulation, oral, 
Transplant rejection, 


phenolic 
hydroxy-6-methoxy-7-methyl-3-oxo-5-
24280-93-1


enteric-coated
general


acid
isobenzofuranyl)-4-methyl-,







Myrophine

467-18-5






N-(Hydroxy-

3569-99-1






methyl)








nicotinamide








N,N,N¢,N¢-

83-81-8






Tetraethyl-








phthalamide








N2-Formyl-

795-13-1






sulflsomidine








N4-b-D-

53274-53-6






Glucosyl-








sulfanilamide








N4-Sulfanilyl-

547-52-4






sulfanilamide








Nabilone

51022-71-0






nabumetone
2-Butanone, 4-(6-methoxy-2-
42924-53-8
GB
1476721
Anti-inflammatory
Arthritis, osteo



naphthalenyl)-[CAS]







N-acetyl-
L-Cysteine, N-acetyl-[CAS]
616-91-1


Anticancer, other
Cancer, general


cysteine








N-Acetyl-

65-82-7






methionine








nadifloxacin
1H,5H-Benzo[ij]quinolizine-2-carboxylic
124858-35-1
U.S.
4,399,134
Quinolone antibacterial
Acne



acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-








1-piperidinyl)-5-methyl-1-oxo-, (+/−)-








[CAS]







nadolol
2,3-Naphthalenediol, 5-[3-[(1,1-
42200-33-9
U.S.
4,346,106
Antihypertensive, 




dimethylethyl)amino]-2-



adrenergic




hydroxypropoxy]-1,2,3,4-tetrahydro-








[CAS]







Nadoxolol

54063-51-3






nafamostat
Benzoic acid, 4-
80251-32-7
EP
450232
GI inflammatory/
Pancreatitis



[(aminoiminomethyl)amino]-, 6-
81525-10-2


bowel disorders




(aminoiminomethyl)-2-naphthalenyl
82956-11-4







ester-[CAS]







nafarelin
Luteinizing hormone-releasing factor
76932-56-4
EP
21234
Releasing hormones
Endometriosis



(pig), 6-[3-(2-naphthalenyl)-D-alanine]-
86220-42-0







[CAS]







Nafcillin

147-52-4






Nafronyl

31329-57-4






naftidrofuryl
2-Furanpropanoic acid, tetrahydro-
31329-57-4


Formulation, modified-
Unspecified



Alpha-(1-naphthalenylmethyl)-, 2-



release, other




(diethylamino)ethyl ester







naftifine
1-Naphthalenemethanamine, N-methyl-
65472-88-0
U.S.
4,282,251
Antifungal
Infection, 



N-(3-phenyl-2-propenyl)-, (E)-[CAS]
65473-14-5



dermatological


naftopidil
1-Piperazineethanol, 4-(2-
57149-07-2
U.S.
3,997,666
Antihypertensive, 
Hypertension, 



methoxyphenyl)-Alpha-[(1-



adrenergic
general



naphthalenyloxy)methyl]-[CAS]







nalbuphine
Morphinan-3,6,14-triol, 17-
20594-83-6
U.S.
3,393,197
Analgesic, other
Pain, general



(cyclobutylmethyl)-4,5-epoxy-,
23277-43-2







(5Alpha,6Alpha)-[CAS]







Nalidixic 

389-08-2






Acid








nalmefene
Morphinan-3,14-diol, 17-
55096-26-9
JP
56167687
Dependence treatment
Poisoning, drug



(cyclopropylmethyl)-4,5-epoxy-6-








methylene-,(5Alpha)-[CAS]







Nalorphine

62-67-9






naloxone
Morphinan-6-one, 17-allyl-4,5Alpha-
357-08-4


Septic shock treatment




epoxy-3,14-dihydroxy-, hydrochloride
465-65-6







[CAS]







naltrexone
Morphinan-6-one, 17-
16590-41-3
U.S.
3,332,950
Dependence treatment
Addiction, narcotic/



(cyclopropylmethyl)-4,5-epoxy-3,14-
16676-29-2



opiate



dihydroxy-, (SAlpha)-[CAS]







NAMI
Imidazolium



Anticancer, other




trans(imidazole)(dimethylsulfoxide)tetra








chlororuthenate (III)







naminidil
Guanidine, N-cyano-N′-(4-
220641-11-2


Dermatological
Alopecia, general



cyanophenyl)-N′′-[(1R)-1,2,2-








trimethylpropyl]-[CAS]







Nandrolone

434-22-0






Naphazoline

835-31-4






Naphthalene

91-20-3






naproxen 
Methanaminium, 1-carboxy-N, N, N-
104124-26-7
U.S.
4,672,077
Antiarthritic, other
Arthritis, rheumatoid


betainate
trimethyl- salt with (R)-6-methoxy-








Alpha-methyl-2-naphthaleneacetic acid








(1:1), sodium salt [CAS]







naproxen
2-Naphthaleneacetic acid, 6-methoxy-
26159-34-2
GB
1,211,134
Analgesic, NSAID
Pain, general



Alpha-methyl-, [CAS]
22204-53-1 






naratriptan
1H-lndole-5-ethanesulfonamide, N-
121679-13-8
EP
303507
Antimigraine
Migraine



methyl-3-(1-methyl-4-piperidinyl)-








[CAS]







Narceine

131-28-2






Narcobarbital

125-55-3






Natamycin

7681-93-8






nateglinide
D-phenylalanine, N-((4-(1-
105816-04-4
EP
196222
Antidiabetic
Diabetes, Type II



methylethyl)cyclohexyl)carbonyl)-, trans








[CAS]







N-Butyldeo-

72599-27-0






xynojirimycin








N-Butylsco-

149-64-4






polammonium








Bromide








NC-503


U.S.
5,643,562
Anti-inflammatory
Amyloidosis


NC-531


U.S.
5,643,562
Cognition enhancer
Alzheimer's disease


NCX-1000


WO
0061604
Hepatoprotective
Cirrhosis, hepatic


NGX-4016
Benzoic acid, 2-(acetyloxy)-, 2-
175033-36-0
WO
9716405
Symptomatic 
Insulin-related 



((nitrooxy)methyl)phenyl ester [CAS]



antidiabetic
metabolic








syndrome


NGX-456
Benzoic acid, 5-amino-2-hydroxy-, 4-
256499-26-0


GI inflammatory/bowel 
Inflammatory bowel 



(nitrooxy)butyl ester [CAS]



disorders
disease


NCX-950
Alpha′-[[(1,1-



Antiasthma
Asthma



dimethylethyl)amino]methyl]-4-hydroxyl








1,3-benzenedimethanol nitrate







n-Docosanol

661-19-8






NE-100
Benzeneethanamine, 4-methoxy-3-(2-
149409-57-4
WO
9307113
Neuroleptic
Schizophrenia



phenylethoxy)-N,N-dipropyl-,








hydrochloride [CAS]







Nealbarbital

561-83-1






nebivolol
2H-1-Benzopyran-2-methanol,
118457-14-0
EP
145067
Antihypertensive, 
Hypertension, 



Alpha,Alpha′
99200-09-6


adrenergic
general



[iminobis(methylene)]bis[6-fluoro-3,4-








dihydro]-, (2R*(R*(R*(S))))-(1+)-[CAS]







nebostinel
N1-(4,4-Dimethylcyclohexyl)-L-
163000-63-3
EP
0688312
Cognition enhancer
Unspecified



isoglutamine







Nebracetam

97205-34-0






nedaplatin
Platinum, diammine[hydroxyacetato(2−)-
95734-82-0
EP
216362 
Anticancer, alkylating




O1,O2]-, (SP-4-3)-[CAS]







nedocromil
4H-Pyrano[3,2-g]quinoline-2,8-
69049-73-6
EP
555718
Antiasthma, 
Rhinitis, allergic, 



dicarboxylic acid, 9-ethyl-6,9-dihydro-
69049-74-7


Ophthalmological
general, Ocular 



4,6-dioxo-10-propyl-[CAS]




disorder, general


nefazodone
3H-1,2,4-Triazol-3-one, 2-[3-[4-(3-
82752-99-6
U.S.
4,338,317
Antidepressant
Depression, general



chlorophenyl)-1-piperazinyl]propyl]-5-
83366-66-9







ethyl-2,4-dihydro-4-(2-phenoxyethyl)-,








[CAS]







nefiracetam
1-Pyrralidineacetamide, N-(2,6-
77191-36-7
U.S.
4,341,790
Cognition enhancer
Dementia, senile, 



dimethylphenyl)-2-oxo-[CAS]




general


nefopam
1H-2,5-Benzoxazocine, 3,4,5,6-
13669-70-0
U.S.
3,487,153
Analgesic, NSAID




tetrahydro-5-methyl-1-phenyl-[CAS]
23327-57-3






Negamycin

33404-78-3






netfinavir
3-Isoquinolinecarboxamide, N-(1,1-
159989-65-8


Antiviral, anti-HIV
Infection, HIV/AIDS



dimethylethyl)decahydro-2-(2-hydroxy-
159989-64-7







3-((3-hydroxy-2-methylbenzoyl)amino)-








4-(phenylthio)butyl)-, (3S- 








(2(2S*,3S*),3Alpha,4aβ,8aβ))-, [CAS]







Nemonapride

75272-39-8






Neostigmine

59-99-4






nepadutant
Cyclo[3-amino-L-alanyl-L-leucyl-N-[2-
183747-35-5
WO
9628467
Antiasthma
Asthma



(acetylamino)-2-deoxy-β-D-








glucopyranosyl]-L-asparaginyl-L-Alpha-








aspartyl-L-tryptophyl-L-phenylalanyl], (4








1)-lactam [CAS]







neramexane
1,3,3,5,5-pentamethylcyclohexylamine
202807-80-5


Dependence treatment
Addiction, alcohol




219810-59-0






neridronic acid
Phosphonic acid, (6-amino-1-
79778-41-9


Musculoskeletal
Osteogenesis 



hydroxyhexylidene)bis-[CAS]




imperfecta


Neriifolin

466-07-9






N-Ethyl-

457-87-4






amphetamine








neticonazole
1H-Imidazole, 1-[2-(methylthio)-1-[2-
130773-02-3
EP
445540
Antifungal
Infection, Candida, 



(pentyloxy)phenyl]ethenyl]-,
130726-68-0



general



monohydrochloride, (E)-[CAS]







netilmicin
D-Streptamine, O-3-deoxy-4-C-methyl-
56391-56-1
GB
1473733 
Aminoglycoside 
Infection, general



3-(methylamino)-B-L-arabinopyranosyl-
56391-57-2


antibiotic




(1-6)-O-[2,6-diamino-2,3,4,6-








tetradeoxy-Alpha-D-glycero-hex-4-








enopyranosyl-(1-4)]-2-deoxy-N1-ethyl-








[CAS]







nevirapine
6H-Dipyrido[3,2-b:2′,3′-e][1,4]diazepin-
129618-40-2
EP
429987
Antiviral, anti-HIV
Infection, HIV/AIDS



6-one, 11-cyclopropyl-5,11-dihydro-4-








methyl-[CAS]







NGD-98-2


WO
9635689
Anxiolytic
Anxiety


Nialamide

51-12-7






Niaprazine

27367-90-4






Nicametate

3099-52-3






nicaraven
3-Pyndinecarboxamide, N,N-(1-methyl
79455-30-4
EP
29602
Neuroprotective
Haemorrhage, 



1,2-ethanediyl)bis-[CAS]




subarachnoid


nicardipine
3,5-Pyridinedicarboxylic acid, 1A-
54527-84-3
U.S.
3,985,758
Neuroprotective
Hypertension, 



dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,
55985-32-5



general



methyl 2-








[methyl(phenylmethyl)amino]ethyl ester








[CAS]







nicergoline
Ergoline-8-methanol, 10-methoxy-1,6-
27848-84-6


Formulation, modified-
Unspecified



dimethyl-, (8/b)-, 5-bromo-3-



release, other




pyridinecarboxylate(ester)







Nicentrol

5868053






Niclosamide

50-65-7






Nicoclonate

10571-59-2






Nicofuranose

15351-13-0






Nicomol

27959-26-8






Nicomorphine

639-48-5






nicorandil
3-Pyndinecarboxamide, N-[2-
65141-46-0
U.S.
4,792,564
Vasodilator, coronary
Hypertension, 



(nitrooxy)ethyl]-[CAS]




general


Nicotinamide

98-92-0






nicotine
Pyridine, 3-(1-methyl-2-pyrrolidinyl)-,
54-11-5


Formulation, inhalable, 
Addiction, nicotine



(5)-[CAS]



other



Nicotinic Acid

59-67-6






Nicotinic Acid 

94-44-0






Benzyl Ester








Nicotinyl 

100-55-0






Alcohol








nifedipine
4-(2′-nitrophenyl)-2,6-dimethyl-3,5-
21829-25-4
GB
1173862
Vasodilator, coronary
Hypertension, 



dicarbomethoxy-1,4-dihydropyridine




general


nifekalant
2,4(1H,3H)-Pyrimidinedione, 6-[[2-[(2-
130636-43-0
EP
369627
Antiarrhythmic
Arrhythmia, general



hydroxyethyl)[3-(4-
130656-51-8







nitrophenyl)propyl]amino]ethyl]amino]-








1,3-dimethyl-, [CAS]







Nifenalol

7413-36-7






Niflumic 

4394-00-7






Acid








Nifuratel

4936-47-4






Nifurfoline

3363-58-4






Nifuroxazide

965-52-6






Nifuroxime

6236051






Nifurpirinol

13411-16-0






Nifurprazine

1614-20-6






Nifurtimox

23256-30-6






Nifurtoinol

1088-92-2






nifurzide
2-Thiophenecarboxylic acid, 5-nitro-, [3
39978-42-2
U.S.
3,847,911
Antidiarrhoeal
Infection, GI tract



(5-nitro-2-furanyl)-2-








propenylidene]hydrazide [CAS]







NIK-254
Gentamicin, sulfate (salt) [CAS]
1405-41-0


Formulation, other
Infection, general


Nikethamide

59-26-7






nilutamide
2,4-Imidazolidinedione, 5,5-dimethyl-3-








(4-nitro-3-(trifluoromethyl)phenyl]-[CAS]
6361 2-50-0
U.S.
4,472,382
Anticancer, hormonal
Cancer, prostate


nilvadipine
3,5-Pyridinedicarboxylic acid, 2-cyano-
75530-68-6
U.S.
4,338,322
Antihypertensive, 
Hypertension, 



1,4-dihydro-6-methyl-4-(3-nitrophenyl)-,



other
general



3-methyl 5-(1-methylethyl) ester [CAS]







nimesulide
Methanesulfonamide, N-(4-nitro-2-
51803-78-2
U.S.
3,840,597
Anti-inflammatory
Pain, general



phenoxyphenyl)-[CAS]







Nimetazepam

2011-67-8 






nimodipine
3,5-Pyridinedicarboxylic acid, 1,4-
66085-59-4
EP
533014
Neuroprotective




dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,








2-methoxyethyl 1-methylethyl ester








[CAS]







Nimorazole

6506-37-2 






nimustine
Urea, N′-[(4-amino-2-methyl-5-
103745-00-2
GB
1374344
Anticancer, alkylating
Cancer, brain



pyrimidinyl)methyl]-N-(2-chloroethyl)-N-
42471-28-3







nitroso-[CAS]
55661-38-6






Ninopterin

2179-16-0






NIP-142
N-[4(S)-(Cyclopropylamino)-3-(R)-

WO
9804542
Antiarrhythmic
Fibrillation, atrial



hydroxy-2,2-dimethyl-7-nitro-3,4-








dihydro-2H-1-benzopyran-6-yl]-4-








methoxybenzeneacetamide







NIP-531
N′-[3,5-Bis(trifluoromethyl)benzyl]-N-[3-



Antipruritic/inflamm, 
Eczema, atopic



[N-(1-(4-fluorobenzyl)benzimidazol-2-yl]



allergic




amino]propyl-N-methylurea








hydrochloride







niperotidine
[(dimethylamino)methyl]furfuryl]thio]
84845-75-0
GB
2104071
Antiulcer
Ulcer, GI, general



ethyl]-2-nitro-N′-piperonyl-1,1-








ethenediamine







nipradilol
2H-1-Benzopyran-3-ol, 3,4-dihydro-8-[2
81486-22-8
EP
42299
Formulation, mucosal, 
Glaucoma



hydroxy-3-[(1-
86247-86-1


topical




methylethyl)amino]propoxy]-, 3-nitrate








[CAS]







Niridazole

61-57-4






nisoldipine
3,5-Pyridinedicarboxylic acid, 1,4-
63675-72-9
GB
1516793
Antihypertensive, other
Hypertension, 



dihydro-2,6-dimethyl-4-(2-nitrophenyl)-,




general



methyl 2-methylpropyl ester-[CAS]







nitazoxanide
Benzamide, 2-(acetyloxy)-N-(5-nitro-2-
55981-09-4
U.S.
5,387,598
Protozoacide
Infection, GI tract



thiazolyl)-[CAS]







nitisinone
1,3-Cyclohexanedione, 2-[2-nitro-4-
104206-65-7
EP
186118
Metabolic and enzyme 
Cirrhosis



(trifluoromethyl)benzoyl]-[CAS]



disorders



nitracrine
1,3-Propanediamine, N,N-dimethyl-N′-
4533-39-5
FR
1458183
Anticancer, other
Cancer, ovarian



(1-nitro-9-acridinyl)-[CAS]
6514-85-8






Nitrazepam

146-22-5






nitrendipine
3,5-Pyridinedicarboxylic acid, 1,4-
39562-70-4
GB
1358951
Antihypertensive, other
Hypertension, 



dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,




general



ethyl methyl ester-[CAS]







nitroflurbi-
(1,1′-Biphenyl)-4-acetic acid, 2-fluoro-
158836-71-6
EP
670825
Urological
Incontinence


profen
Alpha-methyl-, 4-(nitrooxy)butyl ester








[CAS]







Nitrofurantoin

67-20-9






Nitrofurazone

59-87-0






nitroglycerin
1,2,3-Propanetriol, trinitrate [CAS]
55-63-0


Formulation, 
Angina, general







transdermal, patch



Nitromersol

133-58-4






nitronaproxen
2-Napthaleneacetic acid, 6-methoxy-
163133-43-5
WO
9509831
Analgesic, NSAID
Pain, post-operative



Alpha-methyl 4-(nitrooxy)butyl ester








(AlphaS)-[CAS]







nitroxazepine
Dibenz[b,f][1,4]oxazepin-11(10H)-one,
16398-39-3
NL
6608671
Antidepressant




10-(3-(dimethylamino)propyl]-2-nitro-,








monohydrochloride [CAS]







Nitroxoline

4008-48-4






nizatidine
1,1-Ethenediamine, N-[2-[[[2-
76963-41-2
EP
49618 
Antiulcer
Ulcer, duodenal



[(dimethylamino)methyl]-4-








thiazolyl]methyl]thio]ethyl]-N′-methyl-2-








nitro-[CAS]







Nizofenone

54533-85-6






NM-3
3-(2-methylcarboxymethyl)-6-methoxy-

JP
08176138
Anticancer, other
Cancer, general



8-hydroxy-isocoumann







NM-702
4-Bromo-5-(3-pyridylmethylamino)-6-[3



Antithrombotic
Peripheral vascular 



(4-chlorophenyl)propoxy]-




disease



3(2H)pyridazinone hydrochloride







N-Methyle-

552-79-4






phedrine








N-Methyle-

554-99-4






pinephnne








N-Methyl-

6284-40-8






glucamine








NN-414
6-chloro-3-(1-methylcyclopropylamino)-



Antidiabetic
Diabetes, Type II



4H-thieno[3,2-e]-[1,2,4]thiadiazine-1,1-








dioxide







NNC-05-
(R)-1-(3-(10,11-dihydro-5H-



Symptomatic 
Neuropathy, 


1869
dibenzo[a,d]cyclohepten-5-ylidene)-1-



antidiabetic
diabetic



propyl)-3-piperidine carboxylic acid







Nogalamycin

1404-15-5






nolatrexed
4(1H)-Quinazolinone, 2-amino-6-
152946-68-4
WO
9320055
Anticancer, 
Cancer, liver



methyl-5-(4-pyridinylthio)-, [CAS]
147149-76-6


antimetabolite



nolomirole
Propanoic acid, 2-methyl-, 5,6,7,8-
138531-51-8
WO
9529147
Cardiostimulant
Heart failure



tetrahydro-6-(methylamino)-1,2-








naphthalenediyl ester, hydrochloride,








(+/−)-[CAS]







nolpitantium
1-Azoniabicyclo[2.2.2]octane, 1-[2-[3-
153050-21-6
EP
591040
GI inflammatory/bowel 
Inflammatory bowel 



(3,4-dichlorophenyl)-1-[[3-(1-



disorders
disease



methylethoxy)phenyl]acetyt]-3-








piperidinyl]ethyl]-4-phenyl-, chloride,








(S)-[CAS]







nomegestrol
19-Norpregna-4,6-diene-3,20-dione, 17
58652-20-3
DE
2522533 
Menstruation 
Menstrual disorder, 



(acetyloxy)-6-methyl-[CAS]



disorders
general


Nomifensine

24526-64-5






Noprylsulfamide

576-97-6






Norbolethone

1235-15-0 






Nordazepam

1088-11-5






Nordefrin

6539-57-7








(unspecified);








74812-63-8








(R*,S*)-(±)-








form






Nordihydro-

27686-84-6






guaiaretic 

(mesa-form);






Acid

500-38-9








(unspecified) 






Norelgestramin, 








Ethinyl








Estradial








Norepinephrine

51-41-2






Norethandrolone

52-78-8






Norethindrone

68-22-4






Norethynodrel

68-23-5






Norfenefrine

536-21-0






norfioxacin
3-Quinolinecarboxylic acid, 1-ethyl-6-
68077-27-0
U.S.
4,146,719
Quinolone 
Infection, general



fluoro-1,4-dihydro-4-oxo-7-(1-
70458-96-7


antibacterial




piperazinyl)-[CAS]







Norgesterone

13563-60-5






Norgestimate

35189-28-7






Norgestrel

6533-00-2






Norgestnenone

848-21-5






Norlevorphanol

1531-1 2-0






Normethadone

467-85-6






Normethandrone

514-61-4






Normorphine

466-97-7






Norphenazone

89-25-8






Norpipanone

561-48-8






Norpseudoe-

492-39-7






phedrine








Nortriptyline

72-69-5






Norvinisterone

6795-60-4






Noscapine

128-62-1






Novembichin

1936-40-9






Novobiocin

303-81-1






Noxiptilin

3362-45-6






Noxythiolin

15599-39-0






NS-1209
Butanoic acid, 2-[[[5-[4-
254751-28-5
WO
9426747
Antiepileptic
Epilepsy, general



[(dimethytamino)sulfonyl]phenyl]








1,2,6,7,8,9-hexahydro-8-methyl-2-oxo-








3H-pyrrolo[3,2-h]isoquinolin-3-








ylidene]amino]oxy]-3-hydroxy-[CAS]







NS-1231
5-(4-chlorophenyl)-6,7,8,9-tetrahydro-



Neuroprotective
Ischaemia, cerebral



1H-pyrolo-(3,2-h]naphthalene-2,3-








dione-3-oxime







NS-126


U.S.
5,063,222
Antiallergic, non-
Rhinitis, allergic, 







asthma 
general


NS-220
2-Methyl-c-5-[4-[5-methyl-2-(4-



Hypolipaemic/
Antherosclerosis



methytphenyl)-4-oxazolyl]butyl]-1,3-



Antitherosclerosis




dioxane-r-2-carboxylic acid







NS-2330
NS 2330 [CAS]
402856-42-2


Cognition enhancer
Alzheimer's disease


NS5A 


U.S.
6,030,785
Antiviral, other
Infection, 


inhibitors





hepatitis-C virus


NS-7
Pyrimidine, 4-(4-fluorophenyl)-2-methyl
178429-67-9
WO
9607641
Neuroprotective
Ischaemia, cerebral



6-[[5-(1-piperidinyl)pentyl]oxy]-,








monohydrochionde [CAS]







NS-8
2-Amino-5-(2-fluorophenyl)-4-methyl-



Urological
Incontinence



1H-pyrrole-3-carbonitrile







NSC-330507
17-Allylaminogeldanamycin



Anticancer, antibiotic
Cancer, general


NSC-619534
2-chloroethyl phenyl selenone



Anticancer, alkylating
Cancer, general


NSC-697726
2,5-diazinidinyl-3-[hydroxymethyl]6-



Anticancer, antibiotic
Cancer, general



methyl-1,4-benzoquinone







N-Sulfanilyl-

120-34-3






3,4-xylamide








NU-6027
2,4-Pyrimidinediamine, 6-
220036-08-8


Anticancer, other
Cancer, general



(cyclohexylmethoxy)-5-nitroso-[CAS]







NV-07
2,4,6(1H,3H,5H)-Pyrimidinetnone, 5-
53745-16-7
U.S.
6,455,032
Antipruritic/inflamm, 
Keratosis



ethyl-5-sec-pentyl-, 2-oxime [CAS]



non-allergic



NVP-SRA880
([3R,4aR,10aR]-1,2,3,4,4a,5,10,10a-



Neurological
Unspecified



Octahydro-6-methoxy-1-methyl-








benz[g]quinoline-3-carboxylic acid-4-(4-








nitrophenyl)piperazine amide,








hydrogen maleate







NW-1029
(S)-(+)-2-[4-(2-



Analgesic, other
Pain, general



fluorobenzyloxy)benzylamino]








propanamide methansulfonate







NXY-059
CPI 22 [CAS]
168021-79-2
U.S.
5,780,510
Neuroprotective
Ischaemia, cerebral


Nylidrin

447-41-6






NZ-314
1-Imidazolidineacetic acid, 3-[(3-
128043-99-2
EP
353198
Symptomatic 
Neuropathy, 



nitrophenyl)methyt]-2,4,5-trioxo-[CAS]



antidiabetic
diabetic


NZ-419
5-hydroxy-1-methylimidazolidine-2,4-

EP
412940
Urological
Renal failure



dione







Obidoxime 

114-90-9






Chloride








OC-108
OC 108 [CAS]
162602-62-2


Vasoprotective, topical
Venous insufficiency


ocinaplon
Methanone, 2-pyridinyl[7-(4-
96604-21-6
EP
129847
Anxiolytic
Generalized anxiety 



pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]-




disorder



[CAS]







Octabenzone

1843-05-6






Octacaine

13912-77-1






Octamoxin

4684-87-1






Octavenne

549-68-8






octenidine
1-Octanamine, N,N-(1,10-decanediyldi-
70775-75-6
WO
8705501
Stomatological
Periodontitis



1(4H)-pyridinyl-4-ylidene)bis-[CAS]
71251-02-0








86767-75-1






Octodrine

543-82-8






Octopamine

104-14-3






Octotiamine

137-86-0






octreotide
L-Cysteinamide, D-phenylalanyl-L-
83150-76-9


Formulation, fixed-
Cancer, general



cysteinyl-L-phenylalanyl-D-tryptophyl-L-



dose combinations




lysyl-L-threonyl-N-[2-hydroxy-1-








(hydroxymethyl)propyl]-, cyclic (2-7)-








disulfide, [R-(R*,R)]-[CAS]







Octyl 

5466-77-3






Methoxy-








cinnamate








ofloxacin
7H-Pyrido[1,2,3-de]-l,4-benzoxazine-6-
82419-36-1
EP
47005
Quinolone 




carboxylic acid, 9-fluoro-2,3-dihydro-3-



antibacterial




methyl-10-(4-methyl-l-piperazinyl)-7-








oxo-, (+/−)-[CAS]







o-lodohippurate

133-17-5






olanzapine
10H-Thieno(2,3-
132539-06-1
EP
454436
Neuroleptic
Schizophrenia



b)(1,5)benzodiazepine, 2-methyl-4-(4-








methyl-1-piperazinyl)-[CAS]







Oleandrin

465-16-7






Oleic Acid

112-80-1






olmesartan 
1H-Imidazole-5-carboxylic acid, 4-(1-
144689-63-4
EP
503785
Antihypertensive, 
Hypertension, 


medoxomil
hydroxy-1-methylethyl)-2-propyl-1-((2-



renin system
general



(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-








yl)methyl)-, (5-methyl-2-oxo-1,3-dioxol-








4-yl) methyl ester [CAS]







olopatadine
11-[(Z)-3-(Dimethylamino)propylidene]-
113806-05-6
EP
235796
Ophthalmological
Conjuctivitis



6,11-dihydrodibenz[b,e]oxepin-2-acetic
140462-76-6







acid, monohydrochloride







olpadronic 
Monosodium 3-dimethylamino-1-
63132-39-8
WO
9619998
Osteoporosis 
Osteoporosis


acid
(hydroxypropylidene)-1,1-



treatment




bisphosphonate







olsalazine
Benzoic acid, 3,3′-azobis[6-hydroxy-
15722-48-2
U.S.
4,559,330
GI inflammatory/
Colitis, ulcerative



[CAS]
53200-51-4


bowel disorders



oltipraz
3H-1,2-Dithiole-3-thione, 4-methyl-5-
64224-21-1
DE
2705641
Anticancer, other
Cancer, general



pyrazinyl-[CAS]







OM-294DP
2-[3(R)-



Anticancer, 
Unspecified



(Dodecanoytoxy)tetradecanamido]-N-[4



immunological




[3(R)-hydroxytetradecanamido]-5-








(phosphonooxy)pentyl]-4-








(phosphonooxy)butyramide.







Omacor
ethyl (5Z,8Z,11Z,14Z,17Z)-eicosa-
81926-94-5


Hypolipaemic/
Hypertri-



5,8,11,14,17-pentaenoate + ethyl
86227-47-6


Antitherosclerosis
glyceridaemia



(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-








4,7,10,13,16,19-hexaenoate







omapatrilat
7H-Pyrido(2,1-b)(1,3)thiazepine-7-
167305-00-2
U.S.
5,508,272
Antihypertensive, renin 
Hypertension, general



carboxylic acid, octahydro-4-((2-



system




mercapto-1-oxo-3-phenylpropyl)amino)








5-oxo, (4S-(4Alpha(R*),7Alpha, 10aβ))-








[CAS]







omeprazole
1H-Benzimidazole, 5-methoxy-2-[[(4-
73590-58-6
U.S.
4,255,431
Antiulcer
Ulcer, GI, general



methoxy-3,5-dimethyl-2-








pyridinyl)methyl]sulfinyl]-[CAS]







omiloxetine
Ethanone, 2-[(3R,45)-3-[(1,3-
176894-09-0


Antidepressant
Depression, general



benzodioxol-5-yloxy)methyl]-4-(4-








fluorophenyl)-1-piperidinyl]-1-(4-








fluorophenyl)-, rel-[CAS]







omoconazole
1H-Imidazole, 1-[2-[2-(4-
74512-12-2
EP
8804
Antifungal
Infection, 



chlorophenoxy)ethoxy]-2-(2,4-




dermatological



dichlorophenyl)-1-methylethenyl]-, (Z)-








[CAS]







Onapristone

96346-61-1






ondansetron
4H-Carbazol-4-one, 1,2,3,9-tetrahydro-
99614-01-4
U.S.
4,847,281
Antiemetic
Chemotherapy-



9-methyl-3-[(2-methyl-1H-imidazol-1-
99614-02-5



induced nausea 



yl)methyl]-[CAS]




and vomiting


ONO-3403
Benzoic acid, 4-[(1E)-3-[(2-ethoxy-2-
181586-07-2


GI inflammatory/bowel 
Unspecified



oxoethyl)-2-propenylamino]-2-methyl-3-



disorders




oxo-1-propenyl]-, 4-








(aminoiminomethyl)phenyl ester,








monomethanesulfonate [CAS]







ONO-4128
1,4,9-Triazaspiro(5.5)undecane-2,5-
342394-93-8


Antiviral, anti-HIV
Infection, HIV/AIDS



dione, 1-butyl-3-(cyclohexytmethyl)-9-








((2,3-dihydro-1,4-benzodioxin-6-








yl)methyl-[CAS]







ONO-8815 Ly
L-lysine (Z)-7-[(1R,2R,3R,5R)-5-chloro-



Labour inhibitor
Labour, preterm



3-hydroxy-2-[(E)-(S)-4-(1-








ethylcyclobutyl)-4-hydroxy-1-








butenyl]cyclopentyl]-5-heptenoate







ONT-093


U.S.
5,756,527
Radio/
Cancer, general







chemosensitizer



OPC-14523
2(1H)-Quinolinone, 1-[3-[4-(3-
145969-30-8
EP
512525
Antidepressant
Depression, general



chlorophenyl)-1-piperazinyl]propyl]-3,4-








dihydro-5-methoxy-[CAS]







OPC-31260
Benzamide, N-[4-[[5-(dimethylamino)-
137975-06-5
WO
9105549
Unspecified




2,3,4,5-tetrahydro-1H-1-benzazepin-1-








yl]carbonyl]phenyl]-2-methyl-







OPC-51803
(5R)-2-[1-(2-chloro-4-(1-



Antidiabetic
Diabeters, insipidus



pyrolidinyl)benzoyl)-2,3,4,5-tetrahydro-








1H-1-benzazepin-5-yl]-N-








isopropytacetamide







OPC-6535
2-Pyridinecarboxylic acid, 6-[2-(3,4-
145739-56-6
WO
9209586
GI inflammatory/bowel 
Inflammatory bowel 



diethoxyphenyl)-4-thiazolyl]-[CAS]



disorders
disease


Opiniazide

2779-55-7






opioid 
2-(4-trifluoromethylphenyl)-N-methyl-[1-



Analgesic, other
Pain, general


analgesics
phenyl-2-(1-pyrolidinyl)ethylacetamide







Opipramol

315-72-0






Orazamide

2574-78-9






orazipone
2,4-Pentanedione, 3-((4-
137109-78-5
EP
440324
Antiasthma
Unspecified



methylsulfonyl)phenyl)methylene)-








[CAS]







Org-12962
Piperazine, 1-[6-chloro-5-
210821-63-9


Antidepressant
Depression, general



(trifluoromethyl)-2-pyridinyl]-,








monohydrochionde [CAS]







Org-24448


U.S.
6,166,008
Neuroleptic
Schizophrenia


oritavancin
Vancomycin, 22-O-(3-amino-2,3,6-
171099-57-3
U.S.
5,840,684
Peptide antibiotic
Infection, 



trideoxy-3-C-methyl-Alpha-L-arabino-




dermatological



hexopyranosyl)-N3′′-[(4′-chloro[1,1′-








biphenyl]-4-yl)methyl]-,(4′′R)-[CAS]







orlistat
L-Leucine, N-formyl-, 1-[(3-hexyl-4-oxo-
96829-58-2
EP
129748
Anorectic/Antiobesity
Obesity



2-oxetanyl)methyl]dodecyl ester, [2S-








[2Alpha(R*),3β,]]-[CAS]







ormeloxifene
Pyrrolidine, 1-[2-(p-(7-methoxy-2,2-
31477-60-8
DE
2329201
Female contraceptive
Contraceptive, 



dimethyl-3-phenyl-4-




female



chromanyl)phenoxy)ethyl]-, trans-








[CAS]







Omidazole

16773-42-5






Omipressin

3397-23-7






Ornithine

70-26-8






ornoprostil
Prost-13-en-1-oic acid, 11,15-dihydro
70667-26-4
U.S.
4,278,688
Prostaglandin
Ulcer, gastric



17,20-dimethyl-6,9-dioxo-, methyl








ester, (11Alpha,13E,15S,17S)-[CAS]







Orotic Acid

65-86-1






Orphenadrine

83-98-7






Orthocaine

536-25-4






Osalmid

526-18-1






osanetant
Acetamide, N-[1-[3-[(3R)-1-benzoyl-3-
160492-56-8
EP
673928
Neuroleptic
Schizophrenia



(3,4-dichlorophenyl)-3-








piperidinyl]propyl]-4-phenyl-4-








piperidinyl]-N-methyl-[CAS]







osaterone
2-Oxapregna-4,6-diene-3,20-dione, 17-
105149-00-6
EP
193871
Prostate disorders
Benign prostatic 



(acetyloxy)-6-chloro-[CAS]




hyperplasia


oseltamivir
1-Cyclohexene-1-carboxylic acid, 4-
196618-13-0
WO
9626933
Antiviral, other
Infection, influenza 



(acetylamino)5-amino-3-(1-




virus



ethylpropoxy)-, ethyl ester, (3R-








(3Alpha,(4β,5Alpha))-[CAS]







OSI-7836
4′-Thio-β-D-arabinofuranosylcytosine



Anticancer, 
Cancer, general







antimetabolite



OSI-7904
Pentanedioic acid, 2-[5-[[(l,2-dihydro-3-
139987-54-5
WO
9119700
Formulation, 
Cancer, general



methyl-1-oxobenzo[f]quinazolin-9-



optimized, 




yl)methyl]amino]-1,3-dihydro-l-oxo-2H-



liposomes




isoindol-2-yl]-, (S)-[CAS]







ospemifene
Ethanol, 2-[4-[(1Z)-4-chloro-1,2-
128607-22-7
WO
9607402
Menopausal 
Osteoporosis



diphenyl-1-butenyl]phenoxy]-[CAS]



disorders



otilonium 
Ethanaminium, N,N-diethyl-N-methyl-2-
26095-59-0
GB
1181406
Antispasmodic
Irritable bowel 


bromide
[[4-[[2-




syndrome



(octyloxy)benzoyl]amino]benzoyl]oxy]-,








bromide [CAS]







Ouabain

630-60-4 






Oxaceprol

33996-33-7






Oxacillin

66-79-5






Oxaflozane

26629.87-8






oxaliplatin
Platinum, (1,2-cyclohexanediamine-
61825-94-3
EP
393575
Anticancer, 
Cancer, colorectal



N,N′)[ethanedioato(2−)-O,O′]-, [SP-4-2-



alkylating




(1R-trans)]-[CAS]







Oxalyt-C
1,2,3-Propanetricarboxylic acid, 2-
28060-67-5
DE
2249274
Urological




hydroxy-, potassium sodium salt [CAS]







Oxamarin

15301-80-1






Oxametacine

27035-30-9






Oxamniquine

21738-42-1






oxandrolone
2-Oxaandrostan-3-one, 17-hydroxy-17-
53-39-4
U.S.
3,128,283
Reproductive/gonad
Sexchromosome



methyl-, (5Alpha,17β)-[CAS]




abnormality, 








Turner's syndrome


Oxantel

36531-26-7






Oxapropanium

541-66-2






oxaprozin
2-Oxazolepropanoic acid, 4,5-diphenyl-
21256-18-8
GB
1206403
Antiarthritic, other
Arthritis, osteo



[CAS]







oxatomide
2H-Benzimidazol-2-one, 1-[3-[4-
60607-34-3
GB
1579365
Antiallergic, non-
Rhinitis, allergic, 



(diphenylmethyl)-1-piperazinyl]propyl]-



asthma
general



1,3-dihydro-[CAS]







oxazepam
7-Chloro-1,3-dihydro-3-hydroxy-5-
604-75-1


Formulation, oral, 
Anxiety, general



phenyl-2H-1,4-benzodiazepin-2-one



orally-disintegrating



oxazolam
Oxazolo[3,2-d][1,4]benzodiazepin-
27167-30-2
U.S.
3,772,371
Anxiolytic




6(5H)-one, 10-chloro-2,3,7,11b-








tetrahydro-2-methyl-11b-phenyl-[CAS]







oxcarbazepine
5H-Dibenz[b,f]azepine-5-carboxamide,
28721-07-5
DE
2011087
Antiepileptic
Epilepsy, general



10,11-dihydro-10-oxo-[CAS]
29331-92-8






Oxeladin

468-61-1






Oxendolone

33765-68-3






Oxethazaine

126-27-2






Oxetorone

26020-55-3






oxiconazole
Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-
64211-45-6
GB
1514870
Antifungal
Infection, fungal, 



imidazol-1-yl)-, O-[(2,4-




general



dichlorophenyl)methyl]oxime, (Z)-








[CAS]







Oxidronic 

15468-10-7






Acid








Oxiniacic 

2398-81-4






Acid








Oxiracetam

62613-82-5






oxitropium
3-Oxa-9-
30286-75-0
GB
1178305
Antiasthma




azoniatricyclo[3.3.1.02,4]nonane, 9-








ethyl-7-(3-hydroxy-1-oxo-2-








phenylpropoxy)-9-methyl-, bromide,








[7(S)-(1Alpha,2β,4β,5Alpha,7β)]-








[CAS]







Oxolamine

959-14-8






Oxolinic 

14698-29-4






Acid








Oxophen-

538-03-4






arsine








Oxprenolol

6452-71-7






Oxybenzone

131-57-7






oxybutynin
Benzeneacetic acid, Alpha-cyclohexyl-
5633-20-5


Formulation, modified-
Incontinence



Alpha-hydroxy-, 4-(diethylamino)-2-



release, othe




butynyl ester-[CAS]







Oxycinchophen

485-89-2






oxycodone
Morphinan-6-one, 4,5-epoxy-14-
76-42-6


Formulation, 
Pain, general



hydroxy-3-methoxy-1 7-methyl-,



transmucosal, nasal




(5Alpha)-







Oxyfedrine

15687-41-9






Oxygent
Octane, 1-bromo-
423-55-2


Haematological
Surgery adjunct



1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-








heptadecafluoro-[CAS]







Oxy-

145-12-0






mesterone








Oxy-

1491-59-4






metazoline








oxy-
Androstan-3-one, 17-hydroxy-2-
434-07-1


Hormone
Anaemia, general


metholone
(hydroxymethylene)-17-methyl-,








(5Alpha,17β)-[CAS]







Oxy-

140-95-4






methurea








oxy-
(5Alpha)-4,5-Epoxy-3,14-dihydroxy-17-
76-41-5


Formulation, modified-
Pain, general


morphone
methylmorphinan-6-one [CAS]



release, immediate



Oxypendyl

5585-93-3






Oxypertine

153-87-7






Oxyphen-

129-20-4






butazone








Oxyphen-

125-53-1






cyclimine








Oxy-

115-33-3






phenisatin








Oxy-

50-10-2 






phenonium








Oxypino-

10136-65-9






cemphone








oxypurinol
1H-Pyrazolo[3,4-d]pyrimidine-
2465-59-0


Antigout
Hyperuricaemia



4,6(5H,7H)-dione [CAS]







Oxytetra-

79-57-2 






cycline








ozagrel
2-Propenoic acid, 3-[4-(1H-imidazol-1-
78712-43-3
GB
2025946
Antithrombotic
Vasospasm, 



ylmethyl)phenyl]-, (E)-[CAS]
82571-53-7



cerebral


p-

536-95-8






(Benzyl-








sulfonamido)








benzoic








Acid








P-l00


U.S.
6,313,177
Antiviral, anti-HIV
Infection, HIV/AIDS


P-1202
Pentanoic acid, 5-amino-4-oxo, methyl
79416-27-6
U.S.
6,034,267
Dermatological
Keratosis



ester, hydrochloride [CAS]







P32/98
Di-(3N-[(2S,3S)-2-amino-3-methyl-



Antidiabetic
Diabetes, Type II



pentanoyl]-1,3-thiazolidine)fumarate







PA-824


WO
9701562
Antimycobacteria
Infection, 








tuberculosis


PACAP 38
Pituitary adenylate cyclase-activating
128606-20-2
U.S.
5,128,242
Neuroprotective
Nerve injury, general



peptide-38 [CAS]







paclitaxel
5β,20-Epoxy-
33069-62-4


Formulation, optimized,
Cancer, breast



1,2Alpha,4,7β,10β,13Alpha-



nanoparticles




hexahydroxytax-11-en-9-one-4,10-








diacetate-2-benzoate-13-(Alpha-








phenylhippurate)







PADRE


U.S.
6,413,935
Immunostimulant, other
Vaccine adjunct


pagoclone
1H-Isoindol-1-one, 2-(7-chloro-1,8-
133737-32-3
U.S.
4,960,779
Anxiolytic
Panic disorder



naphthyridin-2-yl)-2,3-dihydro-3-(5-








methyl-2-oxohexyl)- (R)-[CAS]







PAI inhibs


WO
9404512
Antithrombotic



palindore
8H-1,4-dioxino[2,3-e]indol-8-
189681-71-8


Neuroleptic
Schizophrenia



one,2,3,7,9-tetrahydro-2-








[(phenylmethyl)amino]methyl]-, 2(5)-,








(2E)-2-butendioate (1:1)







Palivizumab

188039-54-5






palonosetron
3a5-2-[(S)-1-Azabicyclo[2.2.2]oct-3-yl]-
135729-62-3
U.S.
5,202,333
Antiemetic
Chemotherapy-



2,3,3a,4,5,6-hexahydro-1-oxo-1H-




induced nausea 



benz[de]isoquinoline hydrochloride




and vomiting


Pamabrom

606-04-2






Pamaquine

491-92-9






pamicogrel
1H-Pyrrole-1-acetic acid, 2-[4,5-bis(4-
101 001-34-7
EP
159677
Antithrombotic
Thrombosis, cerebral



methoxyphenyl)-2-thiazolyl]-, ethyl








ester [CAS]







pamidronate
(3-Amino-1-
40391-99-9


Formulation, implant
Hypercalcaemia of



hydroxypropylidene)diphosphonic acid-




malignancy



[CAS]







p-Aminobenzoic 

150-13-0 






Acid








p-Aminohippuric 

61-78-9 






Acid








p-Amino-

70-69-9 






propiophenone








p-Amino-

65-49-6






salicylic Acid








Panavir
4,4′-isopropylidenedithiobis-2,6-di-t-



Neuroprotective
Vasospasm, cerebral



butylphenol







Pancuronium

15500-66-0






Panipenem

87726-17-8






Pantethine

16816-67-4






pantoprazole
1H-Benzimidazole, 5-(difluoromethoxy)-
102625-70-7
EP
166287
Antiulcer
Ulcer, duodenal



2-[[(3,4-dimethoxy-2-








pyndinyl)methyl]sulflnyl]-[CAS]







Pantothenic 

79-83-4






Acid








Papain








Papaverine

58-74-2






paracetamol
Acetamide, N-(4-hydroxyphenyl)-
103-90-2


Formulation, oral, other, 
Pain, general



[CAS]



modified-release



Paraflutizide

1580-83-2






Paraldehyde

123-63-7






Paramethadione

115-67-3






Paramethasone

53-33-8






Paranyline

1729-61-9






Parathyroid 

9002-64-6






Hormone








parecoxib
Propanamide, N-((4-(5-methyl-3-phenyl-
198470-85-8
WO
9738986
Analgesic, NSAID
Pain, post-operative



4-isoxazolyl)phenyl)sulfonyl)-, sodium








salt [CAS]







Parethoxycaine

94-23-5






Pargyline

555-57-7






paricalcitol
19-Nor-9,10-secoergosta-5,7,22-triene-
131918-61-1
EP
387077
Hormone
Hyperparathyroidism



1,3,25-triol, (1Alpha,3β,7E,22E)-[CAS]







paromomycin
O-2-Amino-2-deoxy-Alpha-D-
7542-37-2


Protozoacide
Infection, 



glucopyranosyl-(1-4)-O-[O-2,6-diamino-




leishmaniasis



2,6-dideoxy-β-L-idopyranosyl-(1-3)-β-D-








ribofuranosyl-(1-5)]-2-deoxy-D-








streptamine







paroxetine
Piperidine, 3-((l,3-benzodioxol-5-
61869-08-7
EP
223403
Antidepressant, 
Depression, general



yloxy)methyl]-4-(4-fluorophenyl)-, (3S-



formulation, oral, 




trans)-[CAS]



orally-disintegrating



Paroxypropione

70-70-2






Parsalmide

30653-83-9






PaTrin-2
4-Bromothenylguanine



Radio/
Cancer, melanoma







chemosensitizer



Pazinaclone

103255-66-9






pazufloxacin
7H-Pyrido[1.2,3-de]-1,4-benzoxazine-6-
127045-41-4
DE
3913245
Quinolone 
Infection, general



carboxylic acid, 10-(1-
127046-45-1


antibacterial




aminocyclopropyl)-9-fluoro-2,3-dihydro-
136905-87-8







3-methyl-7-oxo-, (S)-[CAS]







p-Bromo-

103-88-8 






acetanilide








PC-NSAIDs


U.S.
4,918,063
Formulation, other
Arthritis, general


PD-0166285
6-(2,6-Dichlorophenyl)-2-[4-








(diethylamino-ethoxy)-phenylamino]-8-








pyrido[2,3-D]pyrimidine-7-one








Anticancer, other







Pecilocin

19504-77-9






pefloxacin
3-Quinolinecarboxylic acid, 1-ethyl-6-
70458-92-3
GB
1598915
Quinolone 
Infection, urinary 



fluoro-1,4-dihydro-7-(4-methyl-1-



antibacterial
tract



piperazinyl)-4-oxo-[CAS]







pegvisomant
Somatotropin (18-aspartic acid, 21-
218620-50-9


Somatostatin
Acromegaly



asparagine, 120-lysine, 167-








asparagine, 168-alanine, 171-serine,








172-arginine, 174-serine, 179-








threonine (human), pegylated [CAS]







Pelletierine

4396-1-4






pemetrexed
L-Glutamic acid, N-[4-[2-(2-amino-4,7-
137281-23-3
U.S.
5,248,775
Anticancer, 
Cancer, 



dihydro-4-oxo-1H-pyrrolo[2,3-
150399-23-8


antimetabolite
mesothelioma



d]pyrimidin-5-yl)ethyl]benzoyl]-,








disodium salt [CAS]







pemirolast
4H-Pyrido[1,2-a]pyrimidin-4-one, 9-
100299-08-9
U.S.
4,457,932
Antiasthma
Asthma



methyl-3-(1H-tetrazol-5-yl)-[CAS]
69372-19-6






Pemoline

2152-34-3






Pempidine

79-55-0






PEN-203


U.S.
5,955,446
Antiviral, other
Infection, human 








papilloma virus


Penamecillin

983-85-7






penbutolol
2-Propanol, 1-(2-cyclopentylphenoxy)-3
38363-32-5
GB
1215751
Antihypertensive, 




[(1,1-dimethylethyl)amino]-,(S)-, sulfate
38363-40-5


adrenergic




(2:1) (salt) [CAS]







penciclovir
6H-Purin-6-one, 2-amino-1,9-dihydro-9
39809-25-1
JP
60058982
Antiviral, other
Infection, herpes 



[4-hydroxy-3-(hydroxymethyl)butyl]-




simplex virus



[CAS]







Penetha mate

808-71-9






penfluridol
4-Piperidinol, 1-[4,4-bis(4-
26864-56-2
DE
2040231
Neuroleptic




fluorophenyl)butyl]-4-[4-chloro-3-








(trifluoromethyl)phenyl]-[CAS]







Penicillamine

52-67-5






Penicillin G

61-33-6






Penicillin G 

1538-09-6






Benzathine








Penicillin G 

6130-64-9






Procaine








Penicillin N

525-94-0






Penicillin O

87-09-2






Penicillin V

87-08-1






Penime-

4599-60-4






picycline








Penntuss


U.S.
4,221,778
Formulation, modified-
Rhinitis, allergic, 







release, other
general


Pentaerythritol 

78-12-6






Chloral








Pentaerythritol 

2209-86-1






Dichlorohydrin








Pentaerythritol

597-71-7






Pentagastrin

5534-95-2 






Pentagestrone

7001-56-1






PentaLyte
Starch, 2-hydroxyethyl ether [CAS]
9005-27-0
U.S.
5,407,428
Plasma substitute
Surgery adjunct


Pentamethonium

541-20-8






pentamidine
Benzenecarboximidamide, 4,4-[1,5-
100-33-4


Formulation, inhalable, 
Infection, 



pentanediylbis(oxy)]bis-[CAS]



systemic
Pneumocystis








jiroveci prophylaxis


Pentazocine

359-83-1






Pentetate

12111-24-9






Pentetic Acid

67-43-6






Pentetreotide

138661-02-6






Penthienate

60-44-6






Pentifylline

1028-33-7






Pentigetide

62087-72-3






Pentisomide

78833-03-1






Pentobarbital

76-74-4






Pentolinium

52-62-0






Pentorex

434-43-5






pentosan
Xylan, [CAS]
37319-17-8
U.S.
5,180,715
Urological
Inflammation, 








urinary tract


pentostatin
Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-
53910-25-1
U.S.
3,923,785
Anticancer, anticancer, 
Cancer, leukaemia, 



deoxy-I1-D-erythro-pentofuranosyl)-



antimetabolite
hairy cell



3,6,7,8-tetrahydro-, (R)-[CAS]







pentoxifylline
1H-Purine-2,6-dione, 3,7-dihydro-3,7-



Neuroprotective
Amyotrophic lateral 



dimethyl-1-(5-oxohexyl)-[CAS]




sclerosis


Pentoxyl

147-61-5






Pentrinitrol

1607-17-6






Pentylene-

54-95-5






tetrazole








peplomycin
Bleomycinamide, N1-[3-[(1-
68247-85-8
U.S.
4,195,018
Anticancer, antibiotic




phenylethyl)amino]propyl]-, (5)-[CAS]







Perazine

84-97-9






Perflubron

423-55-2






Perfosfamide

62435-42-1;








39800-16-3








(unspecified)






pergolide
Ergoline, 8-[(methylthio)methyl]-6-
66104-22-1
U.S.
4,797,405
Antiparkinsonian
Parkinson's disease



propyl-, (8β)-, monomethanesulfonate-
66104-23-2







[CAS]







Perhexiline

6621-47-2






Pencyazine

2622-26-6






perifosine
Piperidinium, 4-
157716-52-4
EP
594999
Anticancer, other
Cancer, prostrate



[[hydroxy(octadecyloxy)phosphinyl]oxy]-








1,1-dimethyl-, inner salt [CAS]







perillyl 
1-Cyclohexene-1-methanol, 4-(1-
536-59-4
U.S.
5,110,832
Anticancer, other
Cancer, breast


alcohol
methylethenyl)-[CAS]







Penmethazine

13093-88-4






perindopril
1H-Indole-2-carboxylic acid, 1-[2-[[1-
107133-36-8
EP
49658
Antihypertensive, renin 
Hypertension, 



(ethoxycarbonyl)butyl],amino]-1-
82834-16-0


system
general



oxopropyl]octahydro-, [2S-
95153-31-4







[1[R*(R*)],2Alpha,3aβ,7aβ]]-, compd.








with 2-methyl-2-propanamine (1:1)








[CAS]







Periodyl

53586-99-5






perisoxal
1-Piperidineethanol, Alpha-(5-phenyl-3-
2139-25-5
JP
04217925
Anti-inflammatory




isoxazolyl)-, 2-hydroxy-1,2,3-
2055-44-9







propanetncarboxylate (2:1) (salt) [CAS]







Pertapine

1977-11-3






Permethnn

52645-53-1






perospirone
1H-Isoindole-1,3(2H)-dione, 2-[4-[4-
129273-38-7
CA
2167004
Neuroleptic
Schizophrenia



(1,2-benzisothiazol-3-yl)-1-
150915-41-6







piperazinyl]butyl]hexahydro-, cis-[CAS]







Perphenazine

58-39-9






Petroleum 

8030-30-6






Benzin








PH-b


U.S.
6,331,286
Antipsoriasis
Psoriasis


Phanquinone

84-12-8






Pharmaprojects 


WO
9638482
Immunological
Unspecified


No. 4994








Pharmaprojects 


WO
9703986
Neuroleptic
Schizophrenia


No. 5325








Pharmaprojects 


WO
0204426
Antiasthma
Asthma


No. 5972








Pharmaprojects 


U.S.
6,057,346
Antiviral, anti-HIV
Infection, HIV/AIDS


No. 6362








Pharmaprojects 
(R)-N-[4-[2-[[2-Hydroxy-2-(3-



Anorectic/Antiobesity
Obesity


No. 6446
pyridinyl)ethyl]amino]ethyl]phenyl]-4-(4-








[4-(trifluoromethyl)phenyl]thiazol-2-








yl]benzenesulfonamide







Pharmaprojects 


WO
0206223
Psychostimulant
Attention deficit 


No. 6590





disorder


Pharmaprojects 


U.S.
6,455,026
Genomics-based drug 
Cancer, brain


No. 6656




discovery



Pharmaprojects 


U.S.
6,299,900
Formulation, other
Pain, general


No. 6691








Pharmaprojects 
3-(6-Aminopyndin-3-yl)-N-methyl-N-[(1-



Antibacterial, other
Infection, general


No. 6743
methyl-1H-indol-2-yl)methyl]acrylamide







Pharmaprojects 
1,2,3,4,10,14b-Hexahydro-6-methoxy-2-



Antidepressant
Depression, general


No. 6748
methyldibenzo[c,f]pyrazino[1,2-








a]azepin







Phenacaine

620-99-5






Phenacemide

63-98-9






Phenacetin

62-44-2






Phenadoxone

467-84-5






Phenallymal

115-43-5






Phenamet

3819-34-9






Phenazocine

127-35-5






Phenazopyridine

136-40-3






Phenbutamide

3149-00-6






Phencyclidine

77-10-1






Phendimetrazine

634-03-7






Phenelzine

51-71-8






Phenesterine

3546-10-9






Phenetharbital

357-67-5






Phenethicillin

132-93-4






Phenetunde

90-49-3






Phenformin

114-86-3






Phenglutanmide

1156-05-4






Phenindamine

82-88-2






Phenindione

83-12-5






Pheniprazine

55-52-7






Pheniramine

86-21-5






Phenmetrazine

134-49-6






Phenobarbital

50-06-6






Phenobutiodil

554-24-5






Phenocoll

103-97-9






Phenoctide

78-05-7






Phenolphthalein

77-09-8






Phenolphthalol

81-92-5






Phenolsulfon-

143-74-8






phthalein








Phenoltetra-

639-44-1






chlorophthalein








Phenopendine

562-26-5






Phenosulfazole

515-54-8






Phenoxy-

59-96-1






benzamine








Phenoxy-

3818-37-9






propazine








Phenprobamate

673-31-4






Phenprocoumon

435-97-2






phenserine
Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-
101246-66-6


Cognition enhancer
Alzheimer's disease



hexahydro-1,3a,8-trimethyl-,








phenylcarbamate (ester), (3aS-cis)-








[CAS]







Phensuximide

86-34-0






Phentermine

122-09-8






Phentetiothalein

18265-54-8 






phentolamine
Phenol, 3-(((4,5-dihydro-1H-imidazol-2-
65-28-1


Formulation, oral, 
Impotence



yl)methyl)(4-methylphenyl)amino)-,
50-60-2


other




monomethanesulfonate (salt) [CAS]







Phenyl 

134-55-4






Acetylsalicylate








Phenyl 

133-11-9






Aminosalicylate








Phenyl 

118-55-8






Salicylate








Phenylbutazone

50-33-9






Phenylephrine

61-76-7






Phenyl-

7568-93-6






ethanolamine








Phenylmercury

102-98-7






Phenylmethyl-

76-94-8






barbituric Acid








phenyl-
Benzenemethanol, Alpha-(1-
14838-15-4


Anorectic/Antiobesity, 



propanolamine
aminoethyl)-, (R*,S*)-(+/−)-[CAS]



formulation, optimized, 








microparticles



Phenylpropyl-

93-88-9






methylamine








Phenylto-

92-12-6






loxamine








Phenyramidol

553-69-5






phenytoin
2,4-Imidazolidinedione, 5,5-diphenyl-
57-41-0


Formulation, oral, 
Epilepsy, general



[CAS]



other



Phethenylate

510-34-9






Phloroglucinol

108-73-6






Pholcodine

509-67-1






Pholednne

370-14-9






Phospho-

67-07-2






creatine








Phospho-

5746-40-7






cysteamine








Phospho-

107-73-3






rylcholine








Phthalyl-

131-69-1






sutfacetamide








Phthalyl-

85-73-4






sutfathiazole








p-Hydroxy-

365-26-4






ephedrine








Phylloquinone

84-80-0






Physostigmine

57-47-6






Phytic Acid

83-86-3






PI-88
D-Mannose, O-6-O-phosphono-Alpha-
185077-23-0


Anticancer, other
Cancer, melanoma



D-mannopyranosyl-(1-3)-O-Alpha-D-








mannopyranosyl-(1-3)-O-Alpha-D-








man nopyranosyl-(1-3)-O-Alpha-D-








mannopyranosyl-(1-2)- hydrogen








sulphate [CAS]







Piberaline

39640-15-8






pibaserod
2H-(1,3)Oxazino(3,2-a)indole-10-
152811-62-6
WO
9318036
Antiarrhythmic
Fibrillation, atrial



carboxamide, N-((1-butyl-4-








piperidinyl)methyl)-3,4-dihydro-[CAS]







Picilorex

62510-56-9






Picloxydine

5636-92-0






Picopenne

21755-66-8






Picosulfate

10040-45-6






Picotamide

32828-81-2






Picumast

39577-19-0 






pidotimod
4-Thiazolidinecarboxylic acid, 3-[(5-oxo-
121808-62-6 
EP
276752
Immunomodulator, 
Infection, respiratory 



2-pyrrolidinyl)carbonyl]-[CAS]



anti-infective
tract lower


Pifarnine

56208-01-6






piketoprofen
Benzeneacetamide, 3-benzoyl-Alpha-
60576-13-8
GB
1436502
Anti-inflammatory, 




methyl-N-(4-methyl-2-pyridinyl)-[CAS]



topical



Pildralazine

64000-73-3






pilocarpine
2(3H)-Furanone, 3-ethyldihydro-4-[(1-
92-13-7


Formulation, implant, 




methyl-1H-imidazol-5-yl)methyl]-, (3S-



Stomatological




cis)-[CAS]







Piloplex
2-Propenoic acid, 2-methyl-, dodecyl
62783-28-2
DE
2636559
Formulation, mucosal, 
Glaucoma



ester, polymer with 2-propenoicacid,



topical




compd. with (3S-cis)-3-ethyldihydro-4-








[(1-methyl-1H-imidazol-5-yl)methyl]-








2(3H)-furanone [CAS]







pilsicainide
1H-Pyrrolizine-7a(5H)-acetamide, N-
88069-49-2
U.S.
4,564,624
Antiarrhythmic
Arrhythmia, 



(2,6-dimethylphenyl)tetrahydro-,
88069-67-4



general



monohydrochloride [CAS]







Pimeclone

534-84-9






pimecrolimus
15,19-Epoxy-3H-pyrido(2,1-
137071-32-0
EP
626385
Antipruritic/inflamm, 
Eczema, atopic



c)(1,4)oxaazacyclotricosine-



allergic




1,7,20,21(4H,23H)-tetrone, 3-(2-(4-








chloro-3-methoxycyclohexyl)-1-








methyletheny)-8-ethyl-








5,6,8,11,12,13,14,15,16,17,18,19,24,25,








26,26a-hexadecahydro-5,19-








dihydroxy-14,16-dimethoxy-4,10,12,18-








tetramethyl-(3S-(3R*E(1S*,3S*,4R*)),








4S*,5R*,8S*,9E*,12R*,14R*,5S*,16R*,








18S8,19S*,26aR*))-[CAS]







Pimefylline

10001-43-1






pimilprost
Acetic acid, [2-[octahydro-5-hydroxy-6-
139403-31-9


Dermatological
Ulcer, general



(3-hydroxy-5-methyl-1-nonenyl)-2-








pentalenyllethoxy]-, methyl ester, [2R-








[2Alpha,3Alpha,4Alpha(1E,3S,5S),5β,








6aAlpha]]-[CAS]







Piminodine

13495-09-5






Pimobendan

74150-27-9

















pimozide
2H-Benzimidazol-2-one, 1-[1-[4,4-bis(4-
2062-78-4
FR
M3695
Neuroleptic















fluorophenyl)butyl]-4-piperidinyl]-1,3-








dihydro-[CAS]







Pinacidil

85371-64-8






pinaverium
Morpholinium, 4-[(2-bromo-4,5-
53251-94-8
EP
406743
Antispasmodic
Irritable bowel 



dimethoxyphenyl)methyl]-4-[2-[2-(6,6-
59995-65-2



syndrome



dimethylbicyclo[3.1.1]hept-2-








yl)ethoxy]ethyl]-, [CAS]







pinazepam
2H-1,4-Benzodiazepin-2-one, 7-chloro-
52463-83-9
DE
2339790
Anxiolytic




1,3-dihydro-5-phenyl-1-(2-propynyl)-








[CAS]







Pindolol

13523-86-9






pioglitazone
2,4-Thiazolidinedione, 5-[(4-[2-(5-ethyl-
111025-46-8
EP
193256
Antidiabetic
Diabetes, Type II



2-pyridinyl)ethoxy]phenyl]methyl]-,
112529-15-4







monohydrochlonde (+/−)-[CAS]







Pipacycline

1110-80-1






Pipamazine

84-04-8






Pipamperone

1893-33-0






Pipazethate

2167-85-3






Pipebuzone

27315-91-9






Pipecurium

52212-02-9 






pipecuronium
Piperazinium, 4,4′-
52212-02-9
GB
1398050
Muscle relaxant
Anaesthesia, adjunct



[(2β,3Alpha,5Alpha,16β,17β)-3,17-
68399-57-5







bis(acetyloxy)androstane-2,16-








diyl]bis[1,1]-dimethyl-, [CAS]







pipemidic acid
Pyrido[2,3-d]pyrimidine-6-carboxylic
51940-44-4
GB
1451911
Antibacterial, other
Infection, urinary 



acid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-




tract



piperazinyl)-[CAS]







Pipenzolate 

125-51-9






Bromide 








Piperacetazine

3819-00-9






piperacillin
4-Thia-1-azabicyclo[3.2.0]heptane-2-
59703-84-3
GB
1508062
Penicillin, injectable
Infection, general



carboxylic acid, 6-[[[[(4-ethyl-2,3-dioxo-
61477-96-1







1-








piperazinyl)carbonyl]amino]phenylacetyl]








amino]-3,3-dimethyl-7-oxo-,[2S-








[2Alpha,5Alpha,6β(S*)]]-[CAS]







Piperazine 

142-88-1






Adipate








Piperidione

77-03-2






Piperidolate

82-98-4






Pipenlate

4546-39-8 






pipenne 


WO
002544
Dermatological
Vitiligo


analogues








Piperocaine

136-82-3






Piperonal

120-57-0






Piperoxan

59-39-2






Piperylone

25 31-4-6






Pipobroman

54-91-1






Piposulfan

2608-24-4 






pipotiazine
Hexadecanoic acid, 2-[1-[3-[2-
37517-26-3
U.S.
4,782,077
Neuroleptic




[(dimethylamino)sulfonyl]-10H-
39860-99-6







phenothiazin-10-yl]propyl]-4-








piperidinyl]ethyl ester [CAS]







Pipoxolan

18174-58-8






Pipradrol

467-60-7






piprozolin
Acetic acid, [3-ethyl-4-oxo-5-(1-
17243-64-0
U.S.
3,971,794
GI inflammatory/bowel 
Moltility dysfunction, 



piperidinyl)-2-thiazolidinylidene]-, ethyl



disorders
GI, general



ester [CAS]







Piracetam

7491-74-9






pirarubicin
5,12-Naphthacenedione, 10-[[3-amino-
72496-41-4
U.S.
4,303,785
Anticancer, antibiotic
Cancer, breast



2,3,6-trideoxy-4-O-(tetrahydro-2H-








pyran-2-yl)-Alpha-L-lyxo-








hexopyranosyl]oxy]-7,8,9,10-tetrahydro-








6,8,11-trihydroxy-8-(hydroxyacetyl)-1-








methoxy-, [8S-[8Alpha,10Alpha(S*)]]-








[CAS]







Pirazolac

71002-09-0






pirbuterol
2,6-Pyridinedimethanol, Alpha6-[[(1,1-
38029-10-6
U.S.
3,786,160
Antiasthma
Asthma



dimethylethyl)amino]methyl]-3-hydroxy-,
38677-81-5







monoacetate (salt) [CAS]
65652-44-0






Pirenoxine

1043-21-6






pirenzepine
6H-Pyrido[2,3-b][1,4]benzodiazepin-6-
28797-61-7
FR
1505795
Antiulcer




one, 5,11-dihydro-11-[(4-methyl-1-
29868-97-1







piperazinyl)acetyl]-[CAS]







piretanide
Benzoic acid, 3-(aminosulfonyl)-4-
55837-27-9
U.S.
4,010,273
Antihypertension, 
Hypertension, general



phenoxy-5-(1-pyrrolidinyl)-[CAS]



diuetic



pirfenidone
2(1H)-Pyridinone, 5-methyl-1-phenyl-
53179-13-8


Respiratory
Fibrosis, pulmonary



[CAS]







piribedil
Pyrimidine, 2-(4-(1,3-benzodioxol-5-
3605-01-4
U.S.
3,299,067
Vasodilator, 
Parkinson's disease



ylmethyl)-1-piperazinyl]-[CAS]



peripheral



Piridocaine

87-21-8






Pirifibrate

55285-45-5






Piritramide

302-41-0






Piritrexim

72732-56-0






pirlindole
1H-Pyrazino[3,2,1-jk]carbazole,
16154-78-2
SU
276060
Antidepressant
Depression, general



2,3,3a,4,5,6-hexahydro-8-methyl-
60762-57-4







[CAS]







pirmenol
(2-Pyndinemethanol, Alpha-[3-(2,6-
61477-94-9
U.S.
4,112,103
Antiarrhythmic
Tachycardia,



dimethyl-1-piperidinyl)propyl]-
68252-19-7



supraventricular



.Alpha.phenyl-, cis-(+)-[CAS]







Piroctone

50650-76-5






Piroheptine

16378-21-5






Piromidic 

19562-30-2






Acid








piroxicam
2H-1,2-Benzothiazine-3-carboxamide,
36322-90-4
U.S.
3,862,319
Anti-inflammatory




4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-








dioxide [CAS]







piroxicam 
(β-Cyclodextrin, compd. with 4-hydroxy-
121696-62-6
EP
153998
Formulation, other
Pain, musculoskeletal


betadex
2-methyl-N-2-pyndinyl-2H-1,2-
96684-39-8







benzothiazine-3-carboxamide 1,1-








dioxide-[CAS]







piroxicam 
2-Propenoic acid, 3-phenyl-, 2-methyl-
87234-24-0
EP 
79639
Antiarthritic, other
Inflammation, general


cinnamate
3-[(2-pyridinylamino)carbonyl]-2H-1,2-








benzothiazin-4-yl ester, 5,5-dioxide








[CAS]







Pirozadil

54110-25-7






Pirprofen

31793-07-4






pitavastatin
6-Heptenoic acid, 7-[2-cyclopropyl-4-(4
147526-32-7
EP
304063
Hypolipaemic/
Hyperlipidaemia, 



fluorophenyl)-3-quinolinyl]-3,5-



Antiatherosclerosis
general



dihydroxy-, calcium salt (2:1), [S-[R*,S*-








(E)]]-[CAS]







pivagabine
N-trimethylacetyl-4-aminobutyric acid
69542-93-4


Neurological
Anxiety, general


pivaloy-
Butanoic acid, (2,2-dimethyl-1-
122110-53-6
EP
302349
Anticancer, other
Cancer, lung, 


loxymethyl
oxopropoxy)methyl ester [CAS]




non-small cell


Pivalylbenz-

306-19-4






hydrazine








Pivampicillin

33817-20-8






pivampiciiiin/

98445-47-7


Penicillin, oral
Infection, general


pivmecillinam 








Pivcefalexin

63836-75-9






pivmecillinam
4-Thia-1-azabicyclo[3.2.0]heptane-2-
32886-97-8
GB
1293590
Penicillin, oral
Infection, general



carboxylic acid, 6-[[(hexahydro-1H-








azepin-1-yl)methylene]amino]-3,3-








dimethyl-7-oxo-, (2,2-dimethyl-1-








oxopropoxy)methyl ester, [25-








(2Alpha,5Alpha,6β)]-[CAS]







pixantrone
Benz[g]isoquinoline-5,10-diane, 6,9-
144675-97-8
EP
503537
Anticancer, other
Cancer, lymphoma, 



bis[(2-aminoethyl)amino]-, (2Z)-2-




non-Hodgkin's



butenedioate(1 :2)








[CAS]







pizotifen
4-(9,10-dihydro-4H-
15574-96-6 
DE
2346747
Antimigraine




benzo[4,5]cyclohepta[1,2-b]thien-4-








ylidene)-1-methylpiperidine







Pizotyline

15574-96-6






PKI-166
Phenol, 4-(4-(((1R)-1-
187724-61-4


Anticancer, other
Cancer, general



phenylethyl)amino)-1H-pyrrolo(2,3-








d)pyrimidin-6-yl)-[CAS]







p-Lacto-

539-08-2






phenetide








Plafibride

63394-05-8






plasminogen 
Plasminogen activator [CAS]
105913-11-9
EP
151996
Fibrinolytic
Infarction, myocardial


activator








Plasmocid

551-01-9






Platonin

3571-88-8






Plaunotol

64218-02-6






PLD-118
Cyclopentanecarboxylic acid, 2-amino-








4-methylene-, (1R,2S)-[CAS]
198022-65-0
EP 
805145
Antifungal
Infection, Candida, 








general


PLD-147
(OC-6-43)-Bis(acetato)(1-



Anticancer, alkylating
Cancer, general



adamantylamine)ammine-dichloro-








platinum (IV)







pleconaril
1,2,4-Oxadiazole, 3-(3,5-dimethyl-4-(3-
153168-05-9
U.S.
5,464,848
Antiviral, other
Infection, respiratory 



(3-methyl-5-isoxazolyl)propoxy)phenyl)-




tract, general



5-(trifluoromethyl)-[CAS]







Plicamycin

18378-89-7






p-Methyldi-

19804-27-4






phenhydramine








PMS-601


WO
0001677
Antiviral, anti-HIV
Infection, HIV/AIDS


Pneumococcal 








Vaccine,








Diphtheria 








Conjugate








Pneumococcal 








Vaccine,








Polyvalent








PNU-288034
N-[[(5s)-3[4[(1,1-dioxido-4-



Antibiotic, other
Infection, general



thiomorpholinyl)3,5-difluorophenyl]-2-








oxo-5-oxazolidinyl]methyl]acetamide]







Podophyllotoxin

518-28-5






polaprezinc
Zinc, bis(N-β-alanyl-L-histidinato-
107667-60-7
EP
303380
Antiulcer
Ulcer, duodenal



N3,OAlpha)-, (T-4)-[CAS]







Poldine 

545-80-2






Methylsulfate








Policresulen

9011-2-3






Polidexide

9064-92-0






polidocanol
Polyethylene glycol monododecyl ether
3055-99-0


Vasoprotective, 
Venous 




9002-92-0


systemic
insufficiency


Poliovirus 








Vaccine








Inactivated








poty-ADPRT 


WO
9845253
Anticancer, other
Cancer, general


inhibitors








Polyestradiol 

28014-46-2






Phosphate








Polyphenon E
Polyphenon E [CAS]
188265-33-0


Antiviral, other
Infection, human 








papilloma virus


Polythiazide

346-18-9






porfimer
Photofrin [CAS]
87806-31-3
U.S.
4,882,234
Anticancer, other
Cancer, lung, 








non-small cell


Porfiromycin

801-52-5






posaconazole
D-threo-Pentitol, 2,5-anhydro-1,3,4-
171228-49-2
U.S.
5,714,490
Antifungal
Infection, fungal, 



trideoxy-2-C-(2,4-difluorophenyl)-4-((4-




general



(4-(4-(1(1S,2S)-1-ethyl-2-








hydroxypropyl)-1,5-dihydro-5-oxo-4H-








1,2,4-triazol-4-yl)phenyl)-1-








piperazinyl)phenoxy)methyl)-1-(1H-








1,2,4-triazol-1-yl)-[CAS]







Posatirelin

78664-73-0






potassium 
Potassium chloride (KCI) [CAS]
7447-40-7


Formulation, oral, 



chloride




enteric-coated



Potassium 

299-27-4






Gluconate








Potassium 

1321-14-8






Guaiacol-








sulfonate








Potassium 

138-84-1






p-Aminobenzoate








Potassium 

7722-64-7






Pemianganate








Povidone

9003-39-8






Povidone-Iodine

25655-41-8






PP-117
3-Pyridinemethanol, hydrofluoride
62756-44-9
DE
2633028
Formulation, oral, other
Unspecified



[CAS]







PR-2699
(−)-(E)-[4-(2,4-dichlorophenyl)-1,3-



Antifungal
Infection, fungal, 



dithiolan-2-ylidene]-1-




general



imidazolylacetonitrile







PR-608
(S)-(−)-1-[4,4-bis(4-fluorophenyl)butyl]-4-



Antiparkinsonian
Parkinson's disease



(2-hydroxy-3-








phenylaminopropyl)piperazine








trihydrochloride







Practolol

6673-35-4






Prajmaline

35080-11-6






Pralidoxime

51-15-0






pralnacasan
6H-Pyridazino(1,2-a)(1,2)diazepine-1-
192755-52-5


Antiarthritic, 
Arthitis, rheumatoid



carboxamide, N-((2R,3S)-2-



immunological




ethoxytetrahydro-5-oxo-3-








furanyl)octahydro-9-((1-








isoquinolinylcarbonyl)amino)-6,10-








dioxo-, (1S,9S)-[CAS]







pramipexole
2,6-Benzothiazolediamine, 4,5,6,7-
104632-26-0
EP
186087
Antiparkinsonian
Parkinson's disease



tetrahydro-N6-propyl-, (5)-[CAS]







pramiracetam
1-Pyrrolidineacetamide, N-[2-[bis(1-
68497-62-1
U.S.
4,145,347
Cognition enhancer
Amnesia



methylethyl)amino]ethyl]-2-oxo-,
72869-16-0







monohydrochloride [CAS]
75733-50-5






Pramiverin

14334-40-8






pramlintide
1,2-Dithia-5,8,11,14,17-
151126-32-8
U.S.
5,124,314
Antidiabetic
Diabetes, Type I



pentaazacycloeicosane, cyclic peptide








deriv. [CAS]







Pramoxine

140-65-8






pranidipine
3,5-Pyridinedicarboxylic acid, 1,4-
99522-79-9
EP
173126
Antihypertensive, other
Hypertension, general



dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,








methyl 3-phenyl-2-propenyl ester, (E)-








[CAS]







Pranlukast

103177-37-3






pranoprofen
5H-[1]Benzopyrano[2,3-b]pyridine-7-
52549-17-4


Formulation, mucosal,
Ocular disorder,



acetic acid, Alpha-methyl-[CAS]



topical
general


prasterone
Androst-5-en-17-one, 3-hydroxy-, (3β)-
53-43-0


Labour inducer




[CAS]







pratosartan
4(3H)-Cycloheptimidazolone, 5,6,7,8-
153804-05-8
U.S.
5,409,947
Antihypertensive,




tetrahydro-2-propyl-3-[[2′-(1H-tetrazol-5








yl)[1,1′-biphenyl]-4-yl]methyl]-[CAS]







pravastatin
1-Naphthaleneheptanoic acid,
81093-37-0
U.S.
4,346,227
Hypolipaemic/
Anthersclerosis



1,2,6,7,8,8a-hexahydro-β,delta,6-
81131-70-6


Antiatherosclerosis




trihydroxy-2-methyl-8-(2-methyl-1-








oxobutoxy)-, monosodium salt, [1S-








[1Alpha(βS*,deltaS*),2Alpha,6Alpha,8β








(R*),8aAlpha]]-[CAS]







Prazepam

2955-38-6






praziquantel
4H-Pyrazino[2,1-a]isoquinolin-4-one, 2-
55268-74-1
U.S.
4,001,411
Schistosomicide




(cyclohexylcarbonyl)-1,2,3,6,7,11b-








hexahydro-[CAS]







prazosin
Piperazine, 1-(4-amino-6,7-dimethoxy-
19216-56-9
U.S.
4,092,315
Antihypertensive,
Hypertension, general



2-quinazolinyl)-4-(2-furanylcarbonyl)-
19237-84-4


adrenergic




[CAS]







Prednicarbate

73771-04-7






prednimustine
Pregna-1,4-diene-3,20-dione, 21-[4-[4-
29069-24-7
GB
1272841
Anticancer, alkylating




[bis(2-chloroethyl)amino]phenyl]-1-








oxobutoxy]-11,17-dihydroxy-, (11β)-








[CAS]







Prednisolone

50-24-8






Prednisolone 21-

5626-34-6






Diethyl-








aminoacetate








prednisolone 
Pregna-1,4-diene-3,20-dione, 11,17-
118244-44-3
EP
332143
Antiarthritic, other
Arthritis, rheumatoid


farnesil
dihydroxy-21-[(3,7,11-trimethyl-1-oxo








2,6,10-dodecatrienyl)oxy]-,








[11β,21(2E,6E)]-[CAS]







Prednisolone 

125-02-0






Sodium








Phosphate








Prednisone

53-03-2






Prednival

15180-00-4






Prednylidene

599-33-7






pregabalin
Hexanoic acid, 3-(aminomethyl)-5-
148553-50-8


Antiepileptic
Epilepsy, general



methyl, (5)-[CAS]







Pregnan-3a-

128-20-1






ol-20-one








Premarin + 
Estra-4,9-dien-3-one, 17-(2-hydroxy-1-
74513-62-5


Menopausal disorders
Hormone 


trimegestone
oxopropyl)-1 7-methyl-, [1711 (5)]-[CAS]




replacement therapy


prenalterol
Phenol, 4-[2-hydroxy-3-[(1-
57526-81-5
GB
1470039
Cardiostimulant




methylethyl)amino]propoxy]-,
61260-05-7







hydrochloride, (S)-[CAS]







Prenoxdiazine

982-43-4






Prenylamine

390-64-7






prezatide
Cuprate(1-), (N2-(N-glycyl-L-histidyl)-L-
130120-57-9


Vulnerary
Wound healing



lysinato)(N2-(N-glycyl-L-histidyl)-L-








lysinato(2-))-, hydrogen, [CAS]







Pridinol

511-45-5






Prifinium

4630-95-9






Prilocaine

721-50-6






Primaquine

90-34-6






Primidone

125-33-7






Prinomastat

192329-42-3






PRO-2000


U.S.
5,614,599
Antiviral, anti-HIV
Infection, HIV 








prophylaxis


Probenecid

57-66-9






Probucol

23288-49-5






procainamide
Benzamide, 4-amino-N-[2-
51-06-9


Formulation, other
Arrhythmia, general



(diethylamino)ethyl]-[CAS]
614-39-1






Procaine

59-46-1






Procarbazine

671-16-9 






procaterol
2(1H)-Quinolinone, 8-hydroxy-5-[1-
59828-07-8







hydroxy-2-[(1-methylethyl)amino]butyl]-,
60443-17-6







monohydrochioride [CAS]
72332-33-3 
GB
1496766 
Antiasthma



prochlorperazine
10H-Phenothiazine,2-chloro-10-[3-(4-
58-38-8


Formulation, oral, 
Nausea and vomiting,



methyl-1-piperazinyl)propyl]-, (Z)-2-
84-02-6


other
general



butenedloate







procodazol
1H-Benzimidazole-2-propanoic acid
23249-97-0
ES
407882
Anticancer, 
Cancer, general



[CAS]



immunological



Procyclidine

77-37-2






Procymate

13931-64-1






Prodipine

31314-38-2






Proflavine

92-62-6






Progabide

62666-20-0






progesterone
Pregn-4-ene-3,20-dione [CAS]
57-83-0


Formulation, 
Amenorrhoea







transmucosal,








systemic



proglumetacin
1H-Indole-3-acetic acid, 1-(4-
57132-53-3
GB
1467568
Anti-inflammatory
Inflammation, 



chlorobenzoyl)-5-methoxy-2-methyl-, 2-
59209-40-4



general



(4-(3-((4-(benzoylamino)-5-








(dipropylamino)-1,5-








dioxopentyl)oxy)propyl)-1-








piperazinyl)ethylester, (+/−)-[CAS]







proglumide
Pentanoic acid, 4-(benzoylamino)-5-
6620-60-6
DE
1518125
Antiulcer
Ulcer, gastric



(dipropylamino)-5-oxo-, (+/−)-[CAS]







Proheptazine

77-14-5






Prolactin

9002-62-4 






Prolintane

493-92-5






Prolonium

123-47-7






Promazine

58-40-2






Promedol

64-39-1






Promegestone

34184-77-5






promestriene
Estra-1,3,5(10)-triene, 17-methoxy-3-
39219-28-8
GB
1337198
Reproductive/gonadal, 
Acne



propoxy-, (17β)-[CAS]



general



Promethazine

60-87-7






Pronethalol

54-80-8






propacetamol
Glycine, N,N-diethyl-, 4-
66532-85-2
U.S.
4,127,671
Formulation, parenteral, 




(acetylamino)phenyl ester [CAS]
66532-86-3


other



propafenone
1-Propanone, 1-[2-[2-hydroxy-3-
54063-53-5
GB
1307455
Antiarrhythmic
Fibrillation, 



(propylamino)propoxy]phenyl]-3-phenyl




ventricular



[CAS]







Propagermanium

12758-40-6






Propallylonal

545-93-7






Propamidine

104-32-5






propane-1,2-
1,2-propanediol
57-55-6


Formulation, dermal, 
Infection, fungal, 


diol




topical
general


Propanidid

1421-14-3






Propantheline

50-34-0






Proparacaine

499-67-2






Propatyl

2921-92-8






propenidazole
ethyl trans-Alpha-acetyl-1-methyl-5-
76448-31-2


Antifungal
Infection, 



nitroimidazole-2-acrylate




trichomoniasis


propentofylline
1H-Purine-2,6-dione, 3,7-dihydro-3-
55242-55-2
GB
1470220
Neuroprotective
Ischaemia, cerebral



methyl-1-(5-oxohexyl)-7-propyl-[CAS]







Propicillin

551-27-9






Propiomazine

362-29-8






Propionic Acid

79-09-4






propionyt L-
1-Propanaminium, 3-carboxy-N,N,N-
119793-66-7
GB
2008578
Vasodilator, peripheral
Peripheral vascular 


carnitine
trimethyl-2-(1-oxopropoxy)-, chloride,
20084-19-1



disease



(R)-[CAS]







Propipocaine

3670-68-6






Propiram

15686-91-6






propiverine
2,2-diphenyl-2-(1-propoxy)acetic acid








(1-methylpiperid-4-yl) ester54556-98-8








hydrochloride
60569-19-9


Urological
Incontinence


Propizepine

1032 1-12-7






propofol
Phenol, 2,6-bis(1-methylethyl)-[CAS]
2078-54-8
U.S.
4,056,635
Anaesthetic, injectable
Anaesthesia


Propoxycaine

550-83-4






Propoxyphene

469-62-5






propranolol
2-Propanol, 1-[(1-methylethyl)amino]-3-
318-98-9


Formulation, modified-
Hypertension, 



(1-naphthalenyloxy)-[CAS]
525-66-6


release, <=24 hr
general


Propylhexednne

101-40-6






Propyliodone

587-61-1






Propylthiouracil 

51-52-5






Propyphenazone

479-92-5






Proquazone

22760-18-5






Proscillaridin

466-06-8






Prostacyclin

35121-78-9






Prostaglandin E1

745-65-3






Prostaglandin E2

363-24-6






Prostaglandin F2a

551-11-1






Prosultiamine

59-58-5






Protein C

60202-16-6






Protheobromine

50-39-5






Prothipendyl

303-69-5






Protiofate

58416-00-5






Protionamide

14222-60-7






protizinic acid
10H-Phenothiazine-2-acetic acid, 7-
13799-03-6
U.S.
3,450,698
Anti-inflammatory




methoxy-Alpha,10-dimethyl-, (+/−)-








[CAS]







Protoanemonin

108-28-1






Protokytol

136-70-9






Protoporphyrin IX

553-12-8






Protriptytine

438-60-8






Pro-Urokinase

82657-92-9






Proxazole

5696-9-3






Proxibarbal

2537-29-3 






proxigermanium
Propanoic acid, 3,3-(1,3-dioxo-1,3-
12758-40-6
FR
2005110
Antiviral, other
Infection, 



digermoxanediyl)bis-[CAS]




hepatitis-B virus


Proxyphylline

603-00-9






Prozapine

3426-8-2






Prucalopride

179474-81-8






prulifloxacin
1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-
123447-62-1
EP
315828
Quinolone 
Infection, respiratory 



carboxylic acid, 6-fluoro-1-methyl-7-[4-



antibacterial
tract, general



[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]








1-piperazinyl]-4-oxo-[CAS]







Pseudocacaine

478-73-9






pseudoephedrine +
Benzenemethanol, Alpha-[1-



Formulation, modified-
Rhinitis, allergic, 


triprolidine
(methylamino)ethyl]-, hydrochloride, [S-



release, other
general



(R*,R*)]-, mixt. with (E)-2-[1-(4-








methylphenyl)-3-(1-pyrrolidinyl)-1-








propenylipyndine monohydrochloride








[CAS]







pseudoephedrine
Benzenemethanol, Alpha-[1-
90-82-4, 


Formulation, oral, other
Infection, respiratory 



(methylamino)ethyl]-, [S-(R*,R*)]-
8054-271, 



tract, general



[CAS]
345-78-8






Psilocybin

520-52-5






PSK-3841
Benzonitrile, 4-[3-(4-hydroxybutyl)-4,4-
154992-24-2


Dermatological
Alopecia, general



dimethyl-2,5-dioxo-1-imidazolidinyl]-2-








(trifluoromethyl)-[CAS]







p-Sulfanilyl-

4393-19-5






benzylamine








PT-141


U.S.
6,051,555
Male sexual 
Impotence







dysfunction



Pteropterin

89-38-3






Puromycin

53-79-2






PX-12
1-Methylpropyl 2-mercaptoimidazolyl



Anticancer, other
Cancer, general


disulfide








Pyrantel

15686-83-6






Pyrazinamide

98-96-4






Pyridinol 

1882-26-4






Carbamate








Pyridostigmine 

101-26-8






Bromide








Pyridoxal 

54-47-7






5-Phosphate








Pyridoxine

58-56-0






Pyrilamine

91-84-9






Pyrimethamine

58-14-0






Pyrinoline

1740-22-3






Pyrisuccideanol

33605-94-6






Pynthione

1121-30-8






Pyrithyldione

77-04-3






Pyritinol

1098-97-1






Pyrocatechol

120-80-9






Pyrogallol

87-66-1






Pyronandine

74847-35-1






Pyrovalerone

3563-49-3






Pyroxylin

9004-70-0






Pyrrobutamine

91-82-7






Pyrrocaine

2210-77-7






Pyrrolnitnn

1018-71-9






Pyrvinium 

3546-41-6






Pamoate








quazepam
2H-1,4-Benzodiazepine-2-thione, 7-
36735-22-5
U.S.
3,845,039
Hypnotic/Sedative
Insomnia



chloro-5-(2-fluorophenyl)-1,3-dihydro-1-








(2,2,2-trifluoroethyl)-[CAS]







Quercetin

117-39-5






quetiapine
Ethanol, 2-[2-(4-
111974-69-7
EP
240228
Neuroleptic
Schizophrenia



dibenzo[b,f][1,4]thiazepin-11-yl-1-
111974-72-2







piperazinyt)ethoxy]-, (E)-2-








butenedloate (2:1) (salt)[CAS]







Quinacillin

1596-63-0






quinacnne
N-(6-Chloro-2-methoxy-9-acridinyl)-N,N
83-89-6


Neurological
Creutzfeidt-Jakob 



diethyl-1,4-pentanediamine + 10H-




disease



Phenothiazine-10-propanamine, 2-








chloro-N,N-dimethyl







quinagolide
Sulfamide, N,N-diethyl-N′-
87056-78-8
EP
77754
Antiprolactin
Hyperprolactinaemia



(1,2,3,4,4a,5,10,10a-octahydro-6-
94424-50-7







hydroxy-1-propylbenzo[g]quinolin-3-yl)-,
97805-49-7







(3Alpha,4aAlpha,10aβ)- (+/−)-[CAS]







quinapril
3-Isoquinolinecarboxylic acid, 2-[2-[[1-
82586-55-8
EP
49605
Antihypertensive, renin 
Hypertension, 



(ethoxycarbonyl)-3-phenylpropyl]amino]
85441-61-8


system
general



1-oxopropyl]-1,2,3,4-tetrahydro-, [3S-
90243-99-5







[2(R*(R*)],3R*]]-[CAS]







quinaprilat
3-Isoquinolinecarboxylic acid, 2-[2-[(1-
82768-85-2
EP
46953
Antihypertensive, renin 
Hypertension, 



carboxy-3-phenylpropyl)amino]-1-



system
general



oxopropyl]-1,2,3,4-tetrahydro-, [35-








[2[R*(R*)],3R*]]-[CAS]







Quinapyramine

20493-41-8






Quinbolone

2487-63-0






Quinestradiol

1169-79-5






Quinestrol

152-43-2






Quinethazone

73-49-4






quinfamide
2-Furancarboxylic acid, 1-
62265-68-3
U.S.
3,997,542
Amoebicide




(dichloroacetyl)-1,2,3,4-tetrahydro-6-








quinolinyl ester [CAS]







quinidine
Cinchonan-9-ol, 6′-methoxy-, (9S)-,
747-45-5


Formulation, modified-
Arrhythmia, general



sulfate (1:1) (salt) [CAS]
56-54-2


release, other



Quinine

130-95-0






Quinocide

525-61-1






Quinupramine

31721-17-2






Quinupristin

120138-50-3






R-107500
cis-2,3,3a,8-tetrahydro-N,N-

WO
9614320
Anxiolytic
Anxiety, general



dimethyldibenz[c,f]isoxazolo[2,3-








a]azepine-2-methanamine







R-667


WO
0204439
COPD treatment
Emphysema, general


rabeprazole
1H-Benzimidazole, 2-[[[4-(3-
117976-89-3
EP
268956
Antiulcer
Ulcer, gastric



methoxypropoxy)-3-methyl-2-
117976-90-6







pyridinyl]methyl]sulfinyl]-, sodium salt-








[CAS]







racecadotril
Glycine, N-[2-[(acetylthio)methyl]-1-oxo
112573-72-5
EP
38758
Antidiarrhoeal
Diarrhoea, general



3-phenylpropyl]-, phenylmethyl ester,
81110-73-8







(+/−)-[CAS]







Racemethorphan

510-53-2






raloxifene
Methanone, [6-hydroxy-2-(4-
82640-04-8
EP
62503
Osteoporosis treatment
Osteoporosis



hydroxyphenyl)benzo[b]thien-3-yl][4-[2-
84449-90-1







(1-piperidinyl)ethoxy]phenyl]-,








hydrochloride [CAS]







raltitrexed
L-glutamic acid, N-[[5-[[(1,4-dihydro-2-
112887-68-0
EP
239362
Anticancer, 
Cancer, colorectal



methyl-4-oxo-6-



antimetabolite




quinazolinyl)methyl]methylamino]-2-








thienylicarbonyl]-[CAS]







ramatroban
9H-Carbazole-9-propanoic acid, 3-[[(4-
116649-85-5 
EP
242518
Antiallergic, non-
Rhinitis, allergic, 



fluorophenyl)sulfonyl]amino]-1,2,3,4-



asthma
perennial



tetrahydro-, (R)-[CAS]







Ramifenazone

3615-24-5 






ramipril
Cyclopenta[b]pyrrole-2-carboxylic acid,
87269-97-4
EP
79022
Antihypertensive, renin 
Heart failure



1-[2-[[1-(ethoxycarbonyl)-3-
87333-19-5


system




phenylpropyl]amino]-1-








oxopropytloctahydro-, [2S-








[1[R*(R)],2Alpha,3aβ,6aβ]]-[CAS]







ramosetron
Methanone, (1-methyl-1H-indol-3-
132907-72-3
EP
381422
Antiemetic
Nausea and 



yl)(4,5,6,7-tetrahydro-1H-benzimidazol-
132036-88-5



vomiting, general



5-yl)-, monohydrochloride, (R)-[CAS]







Ramot project 


U.S.
5,730,992
Dermatological
Unspecified


No. 1097








Ranimustine

58994-96-0






ranitidine
1,1-Ethenediamine, N-[2-([[5-
66357-35-5
U.S.
4,128,658
Antiulcer
Ulcer, duodenal



[(dimethylamino)methyl]-2-








furanyl]methyl]thio]ethyl]-N′-methyl-2-








nitro-[CAS]







ranitidine 
1,2,3-Propanetricarboxylic acid, 2-
128345-62-0
EP
533281
Antiulcer
Ulcer, duodenal


bismuth citrate
hydroxy-bismuth(3+) salt (1:1), compd.








with N-(2-(((5-((dimethylamino)methyl)-








2-furanyl)methyl)thio)ethyl)-N′-methyl-2








ni1-ethenediamine (1:1)-[CAS]







ranolazine
1-Piperazineacetamide, N-(2,6-
95635-55-5
EP
126449
Antianginal
Angina, general



dimethylphenyl)-4-(2-hydroxy-3-(2-
95635-56-6







methoxyphenoxy)propyl]-, (+/−)-[CAS]







Ranpirnase

133737-96-9






Rapacuronium

156137-99-4






rasagiline
1H-Inden-1-amine, 2,3-dihydro-N-2-
161735-79-1
U.S.
5,457,133
Antiparkinsonian
Parkinson's disease



propynyl-, (R)-, [CAS]







Raubasine

483-04-5






ravuconazole
Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-
182760-06-1


Antifungal
Infection, 



difluorophenyl)-2-hydroxy-1-methyl-3-




meningitis,



(1H-1,2,4-triazol-1-yl)propyl]-4-




general



thiazolyl]-[CAS]







raxofeiast
2-Benzofuranacetic acid, 5-(acetyloxy)-
128232-14-4
U.S.
4,999,350
Symptomatic 
Nephropathy, 



2,3-dihydro-4,6,7-trimethyl-, (+)-[CAS]



antidiabetic
diabetic


razoxane
2,6-Piperazinedione, 4,4′-(1-methyl-1,2-
21416-67-1,
GB
1234935
Anticancer, other
Cancer, general



ethanediyl)bis-[CAS]
21416-87-5






RC-529
Tetradecanoic acid (1R)-1-(2-((2-((2-
216014-46-9


Immunostimulant, 
Vaccine adjunct



deoxy-3-O-((3R)-1-oxo-3-((1-



other




oxotetradecyl)oxy)tetradecyl)amino-4-








O-phosphono-β-D-








glucopyranosyl)oxy)ethyl)amino)-2-








oxoethyl)dodecyl ester, compd. with








N,N-diethylethanamine (1:1) [CAS]







rebamipide
4-Quinolinepropanoic acid, Alpha-[(4-
90098-04-7
DE
3324034
Antiulcer




chlorobenzoyl)amino]-1,2-dihydro-2-








oxo-[CAS]







rebimastat
L-Valinamide, N-((2S)-2-mercapto-1-
259188-38-0


Anticancer, other
Cancer, lung, 



oxo-4-(3,4,4-trimethyl-2,5-dioxo-1-




non-small cell



imidazolidinyl)butyl)-L-leucyl-N,3-








dimethyl-[CAS]







reboxetine
Morpholine, 2-[(2-
71620-89-8,
U.S.
4,229,449
Antidepressant
Depression, general



ethoxyphenoxy)phenylmethyl]-, (R*,S*)-
98769-81-4







[CAS]







Remacemide

128298-28-2






remifentanil
1-Piperidinepropanoic acid, 4-
132539-07-2,
EP
383579
Analgesic, other
Pain, general



(methoxycarbonyl)-4-((1-
132875-61-7







oxopropyl)phenylamino)-methyl ester-








[CAS]







reminertant
Tricyclo[3.3.1.13,7]decane-2-carboxylic
146362-70-1
EP
699438
Neuroleptic
Schizophrenia



acid, 2-[[[1-(7-chloro-4-quinolinyl)-5-








(2,6-dimethoxyphenyl)-1H-pyrazol-3-








yl]carbonyl]amino]-[CAS]







Remoxipride

80125-1 4-0






renzapride
Benzamide, 4-amino-N-1-
109872-41-5
JP
58188885
Gastroprokinetic
Irratable bowel 



azabicyclo[3.3.1]non-4-yl-5-chloro-2-
88721-77-1



syndrome



methoxy-[CAS]







repaglinide
Benzoic acid, 2-ethoxy-4-[2-[[3-methyl-
135062-02-1
WO
9300337
Antidiabetic
Diabetes, Type II



1-[2-(1-piperidinyl)phenyl]butyl]amino]-








2-oxoethyl]-, (5)-[CAS]







repertaxin 
2(R)-4-lsobutylphenylpropionyl

WO
0024710
Cardiovascular
Reperfusion injury


L-lysine salt
methanesulfonamide L-lysine salt







repinotan
1,2-Benzisothiazol-3(2H)-one, 2-(4-
144980-29-0
U.S.
5,137,901
Neuroprotective
Ischaemia, cerebral



(((3,4-dihydro-2H-1-benzopyran-2-
144980-77-8







yl)methyl)amino)butyl)-, 1,1-dioxide,








monohydrochloride [CAS]







repirinast
4H-Pyrano[3,2-c]quinoline-2-carboxylic
73080-51-0
U.S.
4,298,610
Antiasthma




acid, 5,6-dihydro-7,8-dimethyl-4,5-








dioxo-, 3-methylbutyl ester [CAS]







Reposal

3625-25-0

















reproterol
1H-Purine-2,6-dione, 7-[3-[[2-(3,5-
13055-82-8
FR
M5969
Antiasthma
Asthma














dihydroxyphenyl)-2-
54063-54-6







hydroxyethyl]amino]propyt]-3,7-dihydro-








1,3-dimethyl-[CAS]







Rescimetol

73573-42-9






Rescinnamine

24815-24-5






Reserpiline

131-02-2






Reserpine

50-55-5






Resibufogenin

465-39-4






resiquimod
1H-Imidazo(4,5-c)quinoline-1-
144875-48-9
U.S.
5,389,640
Antiviral, other
Infection, 



ethanol(ethoxymethyl)-Alpha, Alpha-




hepatitis-C virus



dimethyl-[CAS]







Resorcinol

108-46-3






Reteplase

133652-38-7






retigabine
Carbamic acid, (2-amino-4-(((4-
150812-12-7
DE
4200259
Antiepileptic
Epilepsy, general



fluorophenyl)methyl)amino)phenyl)-,








ethyl ester [CAS]







retinoic acid
Retinoic acid [CAS]
302-79-4


Formulation, parental, 
Cancer, leukaemia, 







other
acute myelogenous


Revimid


U.S.
6,281,230
Anticancer, other
Cancer, myeloma


R-flurbiprofen
[1,1-Biphenyl]-4-acetic acid, 2-fluoro-
5104-49-4


Anticancer, other
Cancer, prostate



Alpha-methyl







Rho (D) 








Immune 








Globuhn








(Human)








Rho-kinase 


WO
0156988
Antiasthma
Unspecified


inhibitors








ribavirin
1H-1,2,4-Triazole-3-carboxamide, 1-β-
36791-04-5
U.S.
4,211,771
Antiviral, other
Infection, 



D-ribofuranosyl-[CAS]




haemorrhagic fever


Riboflavin

146-17-8 






ribostamycin
D-Streptamine, O-2,6-diamino-2,6-
25546-65-0
GB
1254883
Aminoglycoside 
Infection, general



dideoxy-Alpha-D-glucopyranosyl-(1-4)-



antibiotic




O-(β-D-ribofuranosyl-(1-5)]-2-deoxy-








[CAS]







Ricinoleic 

141-22-0






Acid








Ridogrel

110140-89-1






rifabutin
Rifamycin XIV, 1′,4-didehydro-1-deoxy-
72559-06-9
U.S.
4,219,478
Antimycobacterial
Infection, 



1,4-dihydro-5′-(2-methylpropyl)-1-oxo-




Mycobacterium



[CAS]




avium complex


rifalazil
Rifamycin VIII, 1′,4-didehydro-1-deoxy-
129791-92-0
EP
366914
Antimycobacterial
Infection, 



1,4-dihydro-3′-hydroxy-5′-(4-(2-
129791-94-2



tuberculosis



methylpropyl)-1-piperazinyt]-1-oxo-
133633-12-2







[CAS]







rifametane
Rifamycin, 3-[[[1-
94168-98-6
EP 
119571
Antimycobacterial
Infection, general



(diethylamino)ethylidene]hydrazono]








methyl]-[CAS]







Rifamide

2750-76-7






rifampicin + 
Rifamycin, 3-[[(4-methyl-1-
61498-94-0


Formulation, fixed-
Infection, general


trimethoprim
piperazinyl)imino]methyl]-, mixt. with 5-



dose combinations




[(3,4,5-trimethoxyphenyl)methyl]-2,4-








pyrimidinediamine [CAS]







Rifampin

13292-46-1






Rifamycin SV

6998-60-3






rifapentine
Rifamycin, 3-[[(4-cyclopentyl-1-
61379-65-5
DE
2608218
Antibiotic, other
Infection, 



piperazinyl)imino]methyl]-[CAS]




tuberculosis


rifaximin
Epoxypentadeca[1,11,13]trienimino)
80621-81-4
GB 
2079270
Antibiotic, other
Infection, GI tract



benzofuro[4,5-e]-pyrido[1,2-








a]benzimidazole-1,15(2H)-dione, 25-








(acetyloxy)-5,6,21,23-tetrahydroxy-27-








methoxy-2,4,11,16,20,22,24,26-








octamethyl-, [25-








(2R*,16Z,18E,20R*,22S*,23S*,24S*,








25R*,26S*,27R*,28E)]







rifaximine 
4-deoxy-4′-methylpyrido[1′,2′-
80621-81-4
BE
888895
Formulation, dermal, 
Infection, 


cream
1,2]imidoazo[5,4-c]rifamycin SV



topical
dermatological


Rilmazafone

99593-25-6






rilmenidine
2-Oxazolamine, N-
54187-04-1
DE
2362754
Antihypertensive, 
Hypertension, 



(dicyclopropylmethyl)-4,5-dihydro-
54249-57-9


adrenergic
general



[CAS]







riluzole
2-Benzothiazolamine, 6-
1744-22-5
EP
50551
Neuroprotective
Amyotrophic lateral 



(trifluoromethoxy)-[CAS]




sclerosis


Rimantadine

13392-28-4






rimazolium
4H-Pyrido[1,2-a]pyrimidinium, 3-
28610-84-6
DE
2461349
Analgesic, NSAID




(ethoxycarbonyl)-6,7,8,9-tetrahydro-1,6-
35615-72-6







dimethyl-4-oxo-, [CAS]







rimexolone
Androsta-1,4-dien-3-one,11-hydroxy-
49697-38-3
DE
2301317
Ophthalmological
Inflammation, ocular



16,17-dimethyl-17-(1-oxopropyl)-,








(11β,16Alpha,17β)-[CAS]







Rimiterol

32953-89-2






rimonabant
1H-Pyrazole-3-carboxamide, 5-(4-
158681-13-1
U.S.
5,624,941
Anorectic/Antiobesity
Obesity



chlorophenyl)-l-(2,4-dichlorophenyl)-4-








methyl-N-1-piperidinyl-,








monohydrochloride [CAS]







riodoxol
1,3-Benzenediol, 2,4,6-triiodo-[CAS]
19403-92-0
U.S.
3,755,251
Antiviral, other



Rioprostil

77287-05-9






risedronate
Phosphonic acid, (1-hydroxy-2-(3-
115436-72-1
EP
304961
Osteoporosis treatment
Paget's disease



pyridinyl)ethylidene)bis-, monosodium








salt







Risedronic 

105462-24-6






Acid








risperidone
4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-
106266-06-2
EP
196132
Neuroleptic, 
Schizophrenia



[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-



formulation, 




piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-



optimized,




methyl-[CAS]



microencapsulate



Ritanserin

87051-43-2






Ritipenem

84845-57-8






ritodrine
Benzenemethanol, 4-hydroxy-Alpha-[1-
23239-51-2
U.S.
3,410,944
Labour inhibitor
Labour, preterm



[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-,
26652-09-5







(R*,S*)-[CAS]







ritonavir
2,4,7,12-Tetraazatridecan-13-oic acid,
155213-67-5
WO
9414436
Antiviral, anti-HIV
Infection, HIV/AIDS



10-hydroxy-2-methyt-5-(1-methylethyl)-








1-(2-(1-methylethyl)-4-thiazolyl)-3,6-








dioxo-8,11-bis(phenylmethyl)-, 5-








thiazolyl-methyl ester, (5S-








(5R*,8R*,10R*,11R*))-[CAS]







Rituximab

174722-31-7






rivastigmine
Carbamic acid, ethylmethyl-, 3-[1-
123441-03-2
DE
3805744
Cognition enhancer
Alzheimer's disease



(dimethylamino)ethyl]phenyl ester, (S)-
129101-54-8







[CAS]







rizatriptan
1H-lndole-3-ethanamine, N,N-dimethyl-
145202-66-0
EP
497512
Antimigraine
Migraine



5-(1H-1,2,4-triazol-1-ylmethyl)-, [CAS]
159776-67-7








144034-80-0






RJR-2403
3-Buten-1-amine, N-methyl-4-(3-
183288-99-5


Cognition enhancer
Alzheimer's 



pyridinyl)-, (3E)-, (2E)-2-butenedioate




disease



(1:1) [CAS]







RNA Stealth 
5-Formyluridine



Antiviral, other
Infection, 


Nucleosides





hepatitis-C virus


Ro-0094889
2′,3′-Di-O-acetyl-5′-vinylcytidine



Anticancer, 
Cancer, general







antimetabolite



Ro-61-1790
2-Pyridinesulfonamide, N-[6-(2-
180384-56-9
WO
9619459
Cardiovascular
Haemorrhage, 



hydroxyethoxy)-5-(2-methoxyphenoxy)-




subarachnoid



2-[2-(1H-tetrazol-5-yl)-4-pyridinyl]-4-








pyrimidinyl]-5-methyl-[CAS]







Rociverine

53716-44-2






rocuronium
Pyrrolidinium, 1-
104855-17-6
EP
287150
Muscle relaxant
Muscle spasm, 



[(2β,3Alpha,5Alpha, 16β, 17β,)-17-
104884-91-5



general



(acetyloxy)-3-hydroxy-2-(4-
119302-91-9







morpholinyl)androstan-16-yl]-1-(2-
143558-00-3







propenyl)-, bromide-[CAS]







rofecoxib
2(5H)-Furanone, 4-(4-
162011-90-7
U.S.
5,474,995
Analgesic, NSAID
Arthritis, osteo



(methylsulfonyl)phenyl)-3-phenyl-








[CAS]







roflumilast
Benzamide, 3-(cyclopropylmethoxy)-N-
162401-32-3
WO
9501338
COPD treatment
Chronic 



(3,5-dichloro-4-pyridinyl)-4-




obstructive



(difluoromethoxy)-[CAS]




pulmonary disease


rokitamycin
Leucomycin V, 4B-butanoate 3B-
74014-51-0
U.S.
4,242,504
Macrolide antibiotic
Infection, general



propanoate [CAS]







Rolipram

61413-54-5






Rolitetracycline

751-97-3






Romurtide

78113-36-7






Ronifibrate

42597-57-9 






ropinirole
2H-Indol-2-one, 4-[2-
91374-20-8
EP
266033
Antiparkinsonian
Parkinson's 



(dipropylamino)ethyl]-1,3-dihydro-,
91374-21-9



disease



monohydrochloride-[CAS]







ropivacaine
2-Piperidinecarboxamide, N-(2,6-
84057-95-4
EP
239710
Anaesthetic, local
Anaesthesia



dimethylphenyl)-1-propyl-, (5)-[CAS]
98717-15-8






Roquinimex

84088-42-6






rosaprostol
Cyclopentaneheptanoic acid, 2-hexyl-5-
56695-65-9
GB
1523355
Prostaglandin




hydroxy-[CAS]







Rosaramicin

35834-26-5






Rose Bengal

632-68-8






rosiglitazone
2,4-Thiazolidinedione, 5-((4-(2-(methyl-
122320-73-4
U.S.
5,002,953
Antidiabetic
Diabetes, Type II



2-pyridinylamino)ethoxy)phenyl)methyl)-,
155141-29-0







(Z)-2-butenedioate (1:1) [CAS]







rosoxacin
3-Quinolinecarboxylic acid, 1-ethyl-1,4-
40034-42-2
U.S.
3,753,993
Quinolone 
Infection, 



dihydro-4-oxo-7-(4-pyridinyl)-[CAS]



antibacterial
gonorrhoea


rostaporfin
Tin, dichloro[ethyl 3,4,20,21-
114494-17-6


Ophthalmological
Macular 



tetradehydro-4,9,14,19-tetraethyl-18,19




degeneration



dihydro-3,8,13,18-tetramethyl-20-








phorbinecarboxylato(2-)-








kappaN23,kappaN24,kappaN25,kappa








N26]-, (OC-6-13)-[CAS]







rosuvastatin
6-Heptenoic acid, 7-(4-(4-fluorophenyl)
147098-20-2
JP
2648897
Hypolipaemic/
Hyperlipidaemia, 



6-(1-methylethyl)-2-



Antiatherosclerosis
general



(methyl(methylsulfonyl)amino)-5-








pyrimdinyl)-3,5-dihydroxy- (S-(R*, S*-








(E))) [CAS]







rotigotine
1-Naphthalenol, 5,6,7,8-tetrahydro-6-
99755-59-6
U.S.
4,564,628
Antiparkinsonian
Parkinson's disease



[propyl[2-(2-thienyt)ethyl]amino]-, (5)-








[CAS]







Rotraxate

92071-51-7






Roxarsone

121-19-7






roxatidine
Acetamide, 2-(acetyloxy)-N-[3-[3-(1-
78628-28-1
EP
24510
Antiulcer
Ulcer, gastric



piperidinylmethyl)phenoxy]propyl]-,
93793-83-0







[CAS]







roxifiban
L-Alanine, 3-(((3-(4-
176022-59-6
U.S.
5,849,736
Antithrombotic
Thrombosis, 



(aminoiminomethyl)phenyl)-4,5-dihydro




general



5-isoxazolyl)acetyl)amino)-N-








(butoxycarbonyl)-, methyl ester, (R)-,








[CAS]







Roxindole

112192-04-8






roxithromycin
Erythromycin, 9-[O-[(2-
80214-83-1
EP
33255
Macrolide antibiotic
Infection, general



methoxyethoxy)methyl]oxime] [CAS]
80214-86-4






RPR-109881A
Benzenepropanoic acid, β-(((1,1-
192573-38-9


Anticancer, other
Cancer, lung, general



dimethylethoxy)carbonyl)amino)-Alpha-








hydroxy-








(1S,2S,4S,7R,8aR,9aS,10aR,12aS,








12bR)-7,12a-bis(acetyloxy)-1-








(benzoyloxy)-








1,3,47,8,9,9a,10,10a,12,12a,12b-








dodecahydro-2-hydroxy-5,13,13-








trimethyl-8-oxo-2,6-methano-2H-








cyclodeca(3,4) cyclopropa (4,5) benz








(1,2-b) oxet-4-yl ester, dihydrate Alpha








R, betaS [CAS]







RPR-130401
4,9-Ethano-3aH-benz[f]isoindole-3a-
210282-69-2
WO
9829390
Anticancer, other
Cancer, general



carboxylicacid, 1,2,3,4,9,9a-hexahydro-








2-[2-(2-methoxyphenyl)-1-oxo-2-








propenyl]-9-(4-methylphenyl)-,








(3aR,4S,9S,9aR)-rel-[CAS]







R-roscovitine


U.S.
6,316,456
Anticancer, other
Cancer, lung, 








non-small cell


RS-0406
N′N′-bis(3-hydroxyphenyl)pyridazine-



Neuroprotective
Alzheimer's 



3,6-diamine




disease


RSR-13

131179-95-8






Rubijervine

79-58-3






rubitecan
1H-Pyrano(3′,4′:6,7)indoiizino(1,2-
91421-42-0
U.S.
6,485,514
Anticancer, other
Cancer, pancreatic



b)quinoline-3,14(4H,12H)-dione, 4-








ethyl-4-hydroxy-10-nitro-, (5)-[CAS]







ruboxistaurin
9H,18H-5,21:12,17-
169939-94-0


Symptomatic 
Retinopathy, 



Dimethenodibenzo(e,k)pyrrolo(3,4-



antidiabetic
diabetic



h)(1,4,13)oxadiazacyclohexadecine-








18,20(19H)-dione,9-








((dimethylamino)methyl)-6,7,10,11-








tetrahydro-, (S)-[CAS]







Rufinamide

106308-44-5






rufloxacin
7H-Pyrido[1,2,3-de]-1,4-benzothiazine-
101363-10-4
EP
165375
Quinolone antibacterial
Infection, general



6-carboxylic acid, 9-fluoro-2,3-dihydro-
102052-47-1







10-(4-methyl-1-piperazinyl)-7-oxo-
106017-08-7







[CAS]







rupatadine
5H-Benzo[5,6]cyclohepta[1,2-
156611-76-6
EP
0577957
Antiallergic, non-
Rhinitis, allergic, 



b]pyridine, 8-chloro-6,11-dihydro-11-[1-



asthma
seasonal



[(5-methyl-3-pyridinyl)methyl]-4-








piperidinylidene]-, trihydrochloride-








[CAS]







Rutin

153-18-4






RWJ-54428
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-
189448-35-9
WO
9713772
Cephalosporin, 
Infection, beta-



carboxylic acid, 7-[[(2Z)-(2-amino-5-



injectable
lactamase resistant



chloro-4-








thiazolyl)(hydroxyimino)acetyl]amino]-3-








[(3-[[(2-aminoethyl)thio]methyl]-4-








pyridinyl]thio]-8-oxo-, (6R,7R)-[CAS]







S-0139
Olean-12-en-28-oic acid, 27-[[3-[5-
193969-54-9
WO
9727314
Cardiovascular
Ischaemia, cerebral



hydroxy-2-[(4-methoxy-1,4-dioxo-2-








butenyl)amino]phenyl]-1-oxo-2-








propenyl]oxy]-3-oxo-[CAS]







S-15535
Piperazine, 1-(2,3-dihydro-1,4-
146998-34-7


Cognition enhancer
Cognitive disorder, 



benzodioxin-5-yl)-4-(2,3-dihydro-1H-




general



inden-2-yl)-[CAS]







S-18886
1-Napthalenepropanoic acid, 6-(((4-
165537-73-5


Antithrombotic
Thrombosis, 



chlorophenyl)sulfonyl)amino)-5,6,7,8-




general



tetrahydro-2-methyl [CAS]







S-34730
7-chloro-6-sulfamoyl-2-(1H)-



Neuroprotective
Unspecified



quinoleinone-3-phosphonic acid







S-3578
7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-



Cephalosporin, 
Infection, general



2(Z)-ethoxyiminoacetamido]-3-(1-(N-



injectable




methylaminopropyl)-1H-imidazo[4,5-








b]pyridinium-4-methyl-3-cephem-4-








carboxytate monosulfate







S-36496
2-{N-[4-(4-



Antiasthma
Asthma



Chlorophenylsulfonylamino)butyl]-N-{3-








[(4-isopropylthiazol-2-








yl)methyloxy]benzyl}sulfamoyl}benzoic








acid







S-36527
2-{N-[4-(4-



Antiasthma
Asthma



Chlorophenylsulfonylamino)butyl]-N-{3-








[2-(4-cyclobutylthiazol-2-








yl)ethyl]benzyl}sulfamoyl}benzoic acid







S-5751
(1R,2R,3S,5S)-7-[2-(5-



Antiallergic, non-
Allergy, general



Hydroxybenzothiophen-3-



asthma




ylcarboxamido)-6,6-








dimethylbicyclo[3.1.1]hept-3yl]-5(Z)-








heptenoic acid







S-8510
Imidazo[4,5-d]pyrano[4,3-b]pyridine,
151466-23-8
EP
556008
Cognition enhancer
Alzheimer's disease



1,6,7,9-tetrahydro-2-(3-isoxazolyl)-,








phosphate (1:1) [CAS]







S-8921
2-Naphthalenecarboxylic acid, 1-(3,4-
151165-96-7
WO
9308155
Hypolipaemic/
Hypercholesterol-



dimethoxyphenyl)-3-(3-ethyl-1-



Antiatherosclerosis
aemia



oxopentyl)-4-hydroxy-6,7,8-trimethoxy-,








methyl ester [CAS]







Sabcomeline

159912-53-5






Sabeluzole

104383-17-7






S-Adenosyl-

29908-03-0






methionine








safinamide
(S)-(+)-2-[4-(3-
133865-89-1
AU
711309
Antiepileptic
Epilepsy, general



fluorobenzyloxy)benzylamino]








propanamide methansulfonate







Salacetamide

487-48-9






Salazo-

2315-8-4






sulfadimidine








salbutamol
1,3-Benzenedimethanol,Alphal-[[(1,1-
18559-94-9
EP
451745
Formulation, 
Asthma



dimethylethyl)amino]methyl]-4-hydroxy-



inhalable, 




[CAS]



topical, dry powder



Salicin

138-52-3






Salicyl Alcohol

90-01-7






Salicylamide

65-45-2






Salicytamide 

25395-22-6






O-Acetic Acid








Salicylanilide

87-17-2






Salicylic Acid

69-72-7






Salicylsulfuric 

89-45-2






Acid








Salinazid

495-84-1






salmeterol
1,3-Benzenedimethanol, 4-hydroxy-
89365-50-4
WO
9006775
Antiasthma
Asthma



Alpha 1-[[[6-(4-
94749-08-3







phenylbutoxy)hexyl]amino]methyl]-, (±)-








1-hydroxy-2-naphthalenecarboxylate








[CAS]







Salsalate

552-94-3






Salverine

6376-26-7






Samarium 

154427-83-5






153Sm








Lexidronam








sampatrilat
L-Tyrosine, N2-(methylsulfonyl)-L-lysyl-
129981-36-8
EP
358398
Antihypertensive, renin 
Hypertension, 



1-[(2S)-3-amino-2-



system
general



carboxypropyl]cyclopentanecarbonyl-








[CAS]







Sancycline

808-26-4






Saperconazole

110588-57-3






sapropterin
4(1H)-Pteridinone, 2-amino-6-(1,2-
69056-38-8
EP
191335
Antidepressant
Hyperphenyl-



dihydroxypropyl)-5,6,7,8-tetrahydro-,
62989-33-7



alaninaemia



dihydrochloride, [6R-[6R*(1R*,2S*)]]-








[CAS]







saquinavir
Butanediamide, N1-[3-[3-[[(1,1-
127779-20-8
EP
432695
Antiviral, anti-HIV
Infection, HIV/AIDS



dimethylethyl)amino]carbonyl]octahydro-








2(1H)-isoquinolinyl]-2-hydroxy-1-








(phenylmethyl)propyl]-2-[(2-








quinolinylcarbonyl)amino]-, [3S-








[CAS]







Saralasin

34273-10-4






saredutant
Benzamide, N-[4-[4-(acetylamino)-4-
142001-63-6
EP
474561
Antiasthma
Asthma



phenyl-1-piperidinyl]-2-(3,4-








dichlorophenyl)butyl]-N-methyl-, (S)-








[CAS]







sarizotan
3-Pyridinemethanamine, N-((3,4-
177975-08-5


Antiparkinsonian
Parkinson's 



dihydro-2H-1-benzopyran-2-yl)methyl)-




disease



5-(4-fluorophenyl)-[CAS]







sarpogrelate
Butanedlaic acid, mono[2-
125926-17-2
EP
398326
Antithrombotic




(dimethylamino)-1-[[2-[2-(3-








methoxyphenyl)ethyl]phenoxy]methyl]








ethyl] ester [CAS]







Satigrel

111753-73-2






satraplatin
Platinum, bis(acetato-
129580-63-8
EP
328274
Anticancer, 
Cancer, prostate



O)amminedichloro(cyclohexanamine)-,



alkylating




(OC-6-43)-[CAS]







Satumomab

144058-40-2






SB-237376
N-[3-[[2-(3,4-



Antiarrhythmic
Fibrillation, atrial



dimethoxyphenyt)ethyl]amino]propyl]-4-








nitrobenzamide, HCl







SB-238039
(5(-2-phenylamino-4-pyrimidinyl)-4-)(4-



Anticancer, other
Cancer, general



fluorophenyl)-1-(4-piperidinyl)imidazole







SB-277011
trans-N-[4-[2-(6-Cyano-1,2,3,4-



Neuroleptic
Schizophrenia



tetrahydroisoquinolin-2-








yl)ethyl]cyclohexyl]-4-








quinolinecarboxamide







Scarlet Red

85-83-6






SCH-00013
Benzonitrile, 4-[2-[3,6-dihydro-4-
217963-18-3
EP 
618204 
Cardiostimulant
Heart failure



(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-








1(2H)-pyridinyl]-1-hydroxyethyl]-[CAS]







Sch-23863
(2-[10,11-Dihydro-5-ethoxy-5H-dibenzo



Immunosuppressant
Inflammation, general



[a,d] cyclohepten-S-yl]-N, N-dimethyl-








ethanamine







Sch-57790
1-Piperazineacetonitrile, 4-cyclohexyl-
221660-80-6


Cognition enhancer
Alzheimer's disease



alpha-[4-[(S)-(4-








methoxyphenyl)sulfinyl]phenyl]-[CAS]







Sch-63390
7H-Pyrazolo[4,3-e][1,2,4]tnazolo[1.5-
174648-45-4


Antiparkinsonian
Parkinson's disease



c]pyrimidin-5-amine, 2-(2-furanyl)-7-(3-








phenylpropyl)-[CAS]







Scillarenin

465-22-5






Scopolamine

51-34-3






Scopolamine 

97-75-6






N-Oxide








scopolamine
Benzeneacetic acid, Alpha-
51-34-3
U.S.
4,262,003
Formulation, transdermal,
Nausea and vomiting,



(hydroxymethyl)-, 9-methyl-3-oxa-9-



other
general



azatricyclo[3.3.1.02,4]non-7-yl ester,








[7(S)-(1Alpha,2β,4β,5Alpha,7β)]-








[CAS]







SGS technology


U.S.
6,046,188
Antiasthma
Unspecified


secalciferol
9,10-Secocholesta-5,7,10(19)-triene-
55721-11-4
EP
301167
Osteoporosis treatment
Osteodystrophy



3,24,25-triol, (3β,5Z,7E,24R)-[CAS]


















secnidazole
1H-lmidazole-1-ethanol, Alpha,2-
3366-95-8
FR
M3270
Protozoacide
Infection,














dimethyl-5-nitro-[CAS]




trichomoniasis


Secobarbital

309-43-3






selegiline
Benzeneethanamine, N,Alpha-dimethyl
14611-51-9
GB
1153578
Antiparkinsonian




N-2-propynyl-, (R)-[CAS]







Seleno-

1464-42-2






methionine








Sematilide

101526-83-4






Semotiadil

116476-13-2 






seocalcitol
1,3-Cyclohexanediol, 5-((1-(6-ethyl-6-
134404-52-7
WO
9100855
Anticancer, other
Cancer, liver



hydroxy-1-methyl-2,4-








octadienyl)octahydro-7a-methyl-4H-








inden-4-ylidene)ethylidene)-4-








methylene-, (1R-








(1Alpha(1R*,2E,4E),3aβ,4E(1R*,3S*,








5Z),7aAlpha))-[CAS]







Sepimostat

103926-64-3






seratrodast
Benzeneheptanoic acid, zeta-(2,4,5-
1103187-07-1
EP
232089
Antiasthma
Asthma



tnmethyl-3,6-dioxo-1,4-cyclohexadien-
112665-43-7







yl)-, (+/−)-[CAS]







sertaconazole
1H-Imidazole, 1-[2-[(7-
99592-32-2
EP
151477
Antifungal
Infection, 



chlorobenzo[b]thien-3-yl)methoxy]-2-




dermatological



(2,4-dichlorophenyl)ethyl]-[CAS]







sertindole
2-Imidazolidinone, 1-[2-[4-[5-chloro-1-
106516-24-9
EP
392959
Neuroleptic
Schizophrenia



(4-fluorophenyl)-1H-indol-3-yl]-1-








pipendinyl]ethyl]-[CAS]







sertraline
1-Naphthalenamine, 4-(3,4-
79559-97-0
EP
30081
Antidepressant
Depression, general



dichlorophenyl)-1,2,3,4-tetrahydro-N-
79617-96-2







methyl-, (1S-cis)-[CAS]
7961 7-97-3






Setastine

64294-95-7






sevelamer
2-Propen-1-amine polymer with
152751-57-0
U.S.
5,496,545
Urological
Renal failure



(chloromethyl)oxirane, hydrochloride
52757-95-6







[CAS]







sevoflurane
Propane, 1,1,1,3,3,3-hexafluoro-2-
28523-86-6
DE
1954268
Anaesthetic, 
Anaesthesia



(fluoromethoxy)-[CAS]



inhalation



SG-210
2H-1,4-Benzothiazine-2-acetic acid,
143162-65-6


Symptomatic 
Neuropathy, 



3,4-dihydro-3-oxo-4-((4,5,7-trifluro-2-



antidiabetic
diabetic



benzothiazolyl)methyl)-[CAS]







sibutramine
Cyclobutanemethanamine, 1-(4-
106650-56-0
GB
2098602
Anorectic/Antiobesity
Obesity



chlorophenyl)-N,N-dimethyl-Alpha-(2-
84485-00-7







methylpropyl)-[CAS]







siccanin
(4aS-
22733-60-4
JP
37003548
Antifungal




(4aAlpha,6aAlpha,11bAlpha,13aR*,13b








Alpha))-l,2,3,4,4a,5,6a,11b,13b-








decahydro-4,4,6a,9-tetramethyl-13H-








benzo[a]furo[2,3,4-mn]xanthen-11-ol







sildenafil
Piperazine, 1-((3-(4,7-dihydro-1-methyl-
171599-83-0
WO
9428902 
Male sexual 
Impotence



7-oxo-3-propyl-1H-pyrazolo(4,3-
139755-83-2


dysfunction




d)pyrimidin-5-yl)-4-








ethoxyphenyl)sulfonyl)-4-methyl, 2-








hydroxy-1,2,3-propanetricarboxylate-








(1:1) [CAS]







silodosin
1H-Indale-7-carboxamide, 2,3-dihydro-
160970-54-7
EP
600675
Urological
Dysuria



1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-








(2,2,2-








trifluoroethoxy)phenoxy]ethyl]amino]








propyl]-[CAS]







Silver Lactate

128-00-7






Silver Picrate

146-84-9






silver 
N′-2-pyrimidinylsulfanilamide
22199-08-2


Anti-infective
Infection, general


sulfadiazine
monosilver salt
68-35-9






Simetride

154-82-5






Simfibrate

14929-11-4






simvastatin
Butanoic acid, 2,2-dimethyl-,
79902-63-9
U.S.
4,444,784
Hypolipaemic/
Hyperlipidaemia, 



1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-



Antiatherosclerosis
general



[2-(tetrahydro-4-hydroxy-6-oxo-2H-








pyran-2-yl)ethyl]-1-naphthalenyl ester,








[1S-








[1Alpha,3Alpha,7β,8β(2S*,4S*),8aβ]]-








[CAS]







Sincalide

25126-32-3 






Sintropium 

79467-19-9






Bromide








Sisomicin

32385-11-8






sitafloxacin
3-Quinolinecarboxylic acid, 7-(7-amino-
127254-12-0
EP
341493
Quinolone 
Infection, general



5-azaspiro[2.4]hept-5-yl)-8-chloro-6-



antibacterial




fluoro-1-(2-fluorocyclopropyl)-1,4-








dihydro-4-oxo-, [1R-








[1Alpha(S*),2Alpha]]-, hydrate







sitamaquine
1,6-Hexanediamine, N,N-diethyl-N′-(6-
5330-29-0


Protozoacide
Infection, 



methoxy-4-methyl-8-quinolinyl)-[CAS]
57695-04-2



leishmaniasis


sitaxsentan
N-(4-Chloro-3-methyl-5-isoxazolyl)-2-
184036-34-8
U.S.
5,464,853
Antihypertensive, other
Hypertension, 



[[4,5-(methylenedioxy)-o-toly]acetyl]-3-




pulmonary



thiophenesulfonamide







sivelestat
Glycine, N-[2-D[4-(2,2-dimethyl-1-
127373-66-4
EP
347168
Respiratory
Systemic 



oxopropoxy)phenyl]sulfonyl]amino]




inflammatory



benzoyl]-[CAS]




response 








syndrome


SJA-6017
Butanamide, 2-[[(4-
190274-53-4
EP
771565
Ophthalmological
Cataract



fluorophenyt)sulfonyl]amino]-N-[(1S)-1-








formyl-3-methylbutyl.).-3-methyl-, (2S)-








[CAS]







SL-65-1498
6-Fluoro-9-methyl-2-phenyl-4-pyrrolidin-

EP
607076
Anxiolytic
Anxiety, general



1-ylcarbonyl)-2,9-dihydro-1H-pyrido[3,4








b]indole-1-one







SLV-306
(3S,2′R)-3-[1-[2′-(Ethoxycarbonyl)-4′-



Antihypertensive, 
Hypertension, 



phenyl-butyl-]-cyclopentan-1-



diuretic
general



carbonylamino]-2,3,4,5-tetra-hydro-2-








oxo-1H-benzapin-1-acetic acid







SLV-308
2(3H)-Benzoxazolone, 7-(4-methyl-1-
269718-83-4


Antiparkinsonian
Parkinson's 



piperazinyl)-, monohydrochloride




disease


Sm153 
Samarate(5-)-153Sm, (((1,2-
160369-78-8


Analgesic, other
Pain, cancer


lexidronam
ethanediylbis(nitrilobis(methylene)))








tetrakis(phosphonato))(8-)-








N,N′,OP,OP′,OP′′,OP′′′)-, pentasodium,








(OC-6-21)-[CAS]







S-Methyl-

4727-40-6






methionine








SMP-300
N-(Aminoiminomethyl)-11-chloro-



Antianginal
Angina, general



5,6,7,8-tetrahydro-8-oxo-4H-








pyrrolo[3,2,1-kl][1]benzazocine-2-








carboxamide monomethanesulfonate








monohydrate







SN-38
(4S)-4,7,11-tnethyl-3,4,12,14-
100286-90-6


Formulation, 
Cancer, 



tetrahydro-4, 10-dihydroxy-3,14-dioxo-



optimized, 
colorectal



1H-pyrano[3′,4′:6,7]indolizino[1,2-



liposomes




b]quindin-9-yl







SNAP-7941
((+)-methyl (4S)-3-{[(3-{4-[3-



Anxiolytic
Anxiety, general



(acetylamino)phenyl]-1-








piperidinyl}propyl)amino] carbonyl}-4-








(3,4-difluorophenyl)-6-(methoxymethyl)








2-oxo-1,2,3,4-tetrahydro-5-








pyrimidinecarboxylate hydrochloride)







SOA-132
2-Naphthalenecarboxamide, N-[2-[4-
143964-80-1


Formulation, 
Asthma



(diphenylmethoxy)-1-piperidinyl]ethyl]-3



inhalable, 




hydroxy-5-(3-pyridinylmethoxy)-[CAS]



topical



soblidotin
L-valinamide, N,N-dimethyl-L-valyl-N-[2-
149606-27-9
WO
9303054
Anticancer, other
Cancer, lung, 



methoxy-4-L2-[1-methoxy-2-methyl-3-




non-small cell



oxo-3-[(2-phenylethyl)amino]propyl]-1-








pyrrolidinyl]-1-(2-methylpropyl)-4-








oxobutyl]-N-methyl-, [25-








[1[1R*(R*),2S*],2R*(1S*,2S*)]]-[CAS]







Sobrerol

498-71-5






sobuzoxane
Carbonic acid, 1,2-ethanediylbis[(2,6-
98631-95-9
EP
140327
Anticancer, other
Cancer, lymphoma, 



dioxo-4,1-




T-cell



piperazinediyl)methylene]bis(2-








methylpropyl) ester [CAS]







Sodium 

127-85-5






Arsanilate








Sodium 

1936-28-3






Arsphenamine








Sodium 








Chloride








Sodium 

14992-59-7






Dibunate








Sodium Folate

6484-89-5






Sodium

149-44-0






Formalde-








hydesulfoxylate








Sodium 

1334-74-3






Glycerophosphate








Sodium 








Hyaluronate








Sodium 

519-26-6






lodomethamate








Sodium Nitrite

7632-00-0






Sodium 

14402-89-2






Nitroprusside








sodium oxybate
Butync acid, 4-hydroxy monosodium
502-85-2


Psychostimulant
Narcolepsy



salt [CAS]







Sodium 

1300-51-2






Phenolsulfonate








sodium 
Butyric acid, 4-phenyl-, sodium salt-
1716-12-7


Formulation, other
Hyperammon-


phenylbutyrate
[CAS]




aemia


sodium 
Sodium phosphate monobasic

U.S.
6,162,464
Formulation, oral, 
Surgery adjunct


phosphate
monohydrate + sodium phosphate



other




dibasic anhydrous







sodium 
3B-hydroxy-5-androsten-17-

EP
380036
Formulation, mucosal, 
Labour, induction


prasterone 
one(sodium sulfate dihydrate)



topical



sulfate








Sodium 

137-40-6






Propionate








sodium 
Benzoic acid, 2-hydroxy-, monosodium
54-21-7


Formulation, oral, 
Pain, general


salicylate
salt [CAS]



solubility-enhanced



Sodium 

139-88-8






Tetradecyl 








Sulfate








sofalcone
Acetic acid, [5-((3-methyl-2-
64506-49-6
GB
1523241
Antiulcer




butenyl)oxy]-2-[3-[4-[(3-methyl-2-








butenyl)oxy]phenyl]-1-oxo-2-








propenyliphenoxy]-[CAS]







Solasulfone

133-65-3






solifenacin
Butanedioic acid compd with (1S)-(3R)-
242478-38-2


Urological
Overactive 



1-azabicyclo(2.2.2)oct-3-yl 3,4-dihydro-




bladder



1-phenyl-2(1H)-isoquinolinecarboxylate








(1:1) [CAS]







Sorbinicate
D-Glucitol, hexa-3-pyridinecarboxylate
6184-06-1
BE
883352
Hypolipaemic/




[CAS]



Antiatherosclerosis



Sorbitol

50-70-4






Sorivudine

77181-69-2






sotalol
Methanesulfonamide, N-[4-[1-hydroxy-
3930-20-9


Antiarrhythmic




2-[(1-methylethyl)amino]ethyl]phenyl]-
959-24-0







[CAS]







Soterenol

13642-52-9






Sozojodolic 

554-71-2






Acid








spaglumic 
L-Glutamic acid, N-(N-acetyl-L-Alpha-
3106-85-2


Formulation, 
Conjuctivitis


acid
aspartyl)-[CAS]
80619-64-3


mucosal, topical



sparfioxacin
3-Quinolinecarboxylic acid, 5-amino-1-
110871-86-8
EP
221463
Quinolone antibacterial




cyclopropyl-7-(3,5-dimethyl-1-








piperazinyl)-6,8-difluoro-1,4-dihydro-4-








oxo-, cis-[CAS]







Sparteine

90-39-1






SPA-S-843
Candicin D, 18-decarboxy-40-demethyl-
202748-83-2
U.S.
5,298,495
Antifungal
Infection, fungal, 



3,7-dideoxo-N3′-




general



((dimethylamino)acetyl)-18-(((2-








(dimethylamino)ethyl)amino)carbonyl)-








3,7-dihydroxy-N47-methyl-5-oxo cyclic








15,19-hemiacetal, comp with L-








ascorbic acid (1:2) [CAS]







Spasmolytol

25333-96-4






SPD-754
2(1H)-Pyrimidinone, 4-amino-1-(2-
160707-69-7
U.S.
6,228,860
Antiviral, anti-HIV
Infection, HIV/AIDS



(hydroxymethyl)-1,3-oxathiolan-4-yl-








(2R-cis)-







Spectinomycin

1695-77-8






SPI-339
4-[3-(4-Oxo-4,5,6,7-tetrahydroindol-



Cognition enhancer
Alzheimer's 



yl)propionylamino]benzoic acid ethyl




disease



ester







Spiperone

749-02-0






spirapril
1,4-Dithia-7-azaspiro[4.4]nonane-8-
83647-97-6
EP
50800
Antihypertensive, renin 
Hypertension, 



carboxylic acid, 7-[2-[[1-



system
general



(ethoxycarbonyl)-3-phenylpropyl]amino]








1-oxopropyl]-, [8S-[7[R*(R*)],8R*]]-








[CAS]







Spirogermanium

41992-23-8






spironolactone
Pregn-4-ene-21-Carboxylic acid, 7-
52-01-7
EP
124147
Formulation, dermal, 
Acne



(acetylthio)-17-hydroxy-3-oxo-,Gamma-



topical




lactone,(7Alpha, 17Alpha)-[CAS]







SR-121463
Benzamide, N-(1,1-dimethylethyl)-4-
185913-78-4
WO
9715556
Cardiostimulant
Heart failure



[[cis-5′-ethoxy-4-[2-(4-








morpholinyl)ethoxy]-2′-








oxospiro[cyclohexa ne-1,3′-[3H]indol]-








1′(2H)-yl]sulfonyl]-3-methoxy-[CAS]







SR-144190
Morpholine, 4-benzoyl-2-(3,4-
201152-86-5
WO
9623787
Anxiolytic
Anxiety, general



difluorophenyl)-2-[2-[4-








[[(dimethylamino)carbonyl]amino]-4-








phenyl-1-piperidinyl]ethyl]-, (2R)-[CAS]







SR-146131
1H-Indole-1-acetic acid, 2-[[[4-(4-chloro-
221671-61-0
WO
9915525
Anorectic/Antiobesity
Obesity



2,5-dimethoxyphenyl)-5-(2-








cyclohexytethyl)-2-








thiazolyl]amino]carbonyl]-5,7-dimethyl-








[CAS]







SR-271425
N-[1-[2-(diethylamino)ethylamino]-7-



Anticancer, alkylating
Cancer, general



methoxy-9-oxo-9H-thioxanthen-4-








ylmethyl]formamide







SR-27897
1H-Indole-1-acetic acid, 2-[[[4-(2-
136381-85-6
EP
432040
Anticancer, other
Cancer, pancreatic



chlorophenyl)-2-








thiazolyl]amino]carbonyl]-[CAS]







SR-31747
Cyclohexanamine, N-(3-(3-chloro-4-
132173-07-0
EP
376850
Anticancer, other
Cancer, myeloma



cyclohexylphenyl)-2-propenyl)-N-ethyl-,








hydrochloride, (Z)-[CAS]







SR-58611
Acetic acid, [[(7S)-7-[[(2R)-2-(3-
121524-09-2
EP
303546
GI inflammatory/bowel 
Irritable bowel 



chlorophenyl)-2-hydroxyethyl]amino]-



disorders
syndrome



5,6,7;8-tetrahydro-2-naphthalenyl]oxy]-,








ethyl ester, hydrochloride [CAS]







SS732


U.S.
5,385,900
Formulation, mucosal, 
Infection, ocular







topical



SS-750
(R)-(−)-2-(2,4-difluorophenyl)-1-

U.S.
6,083,968
Antifungal
Infection, fungal, 



(ethylsulfonyl)-1,1-difluoro-3-(1H-1,2,4-




general



triazol-1-yl)-2-propanol







β-alethine
Propanamide, N, N(dithiodi-2,1-
646-08-2


Anticancer, 
Cancer, myeloma



ethanediyl)bis(3-amino)-[CAS]



immunological



SSR-149415
(2S,4R)-1-[5-chloro-1-[(2,4-

WO
0155130
Antidepressant
Depression, general



dimethoxyphenyl)sulfonyl]-3-(2-








methoxy-phenyl)-2-oxo-2,3-dihydro-1H-








indol-3-yl]-4-hydroxy-N,N-dimethyl-2-








pyrrolidine carboxamide







SSR-180575
2-(7-chloro-5-methyl-4-oxo-3-phenyl-



Neuroprotective
Unspecified



4,5-dihydro-3H-pyridazino[4,5-6]indol-1-








yl)-N,N-dimethylacetamide







SSR-181507
(3-Exo)-8-benzoyl-N-[[(2S)-7-chloro-2,3-

U.S.
6,221,879
Neuroleptic
Schizophrenia



dihydro-1,4-benzodioxin-2-yl]methyl]-8-








azabicyclo[3.2.1]octane-3-








methanamine HCl







SSR-591813
(5aS,8S,10aR)-5a,6,9,1 0-tetrahydro,



Dependence, treatment
Addiction, nicotine



7H,11H-8,10a-








methanopyrido[2′,3′:5,6]pyrano[2,3-








d]azepine







SST-101
D-Glucitol, 1,4:3,6-dianhydro-, dinitrate
87-33-2


Formulation, 
Angina, general



[CAS]



transdermal, other



SSY-726
(−)-(R)-3-Methyl-3-(methylsuifonyl)-1-

U.S.
5,147,886
Antifungal
Infection, fungal, 



(1,2,4-triazol-1-yl)-2-[4-




general



(trifluoromethyl)phenyl]-2-butanol







ST-200
1-Propanaminium, 2-(acetyloxy)-3-
5080-50-2
DE
3015635
Cognition enhancer
Dementia, senile, 



carboxy-N,N,N-trimethyl-, chloride, (R)-




general



[CAS]







stachyflin


WO
9711947
Antiviral, other
Infection, influenza 








virus


Stallimycin

636-47-5






Stampidine


U.S.
6,350,736
Antiviral, anti-HIV
Infection, HIV/AIDS


Stannous 

15578-26-4






Pyrophosphate








stannsoporfin
(OC-6-13)-Dihydrogen dichloro[7,12-
106344-20-1


Hepatoprotective
Hyperbilirubin-



diethyl-3,8,13,17-tetramethyl-21H,23H-




aemia



porphine-2,18-dipropanoato(4-)-








N21,N22,N23,N24]stannate(2-)







Stanolone

521-18-6






Stanozolol

10418-03-8 








(2¢Hform);








302-96-5








(1¢H form)






Staph aureus 


U.S.
6,376,652
Genomics-based 
Infection, MRSA


ther




drug discovery



STAT4 


WO
9629341
Immunosuppressant
Unspecified


inhibitors








stavudine
Thymidine, 2′,3-didehydro-3′-deoxy-
3056-17-5
EP
501511
Antiviral, anti-HIV
Infection, HIV/AIDS



[CAS]







Stenbolone

5197-58-0 






stepronin
Glycine, N-[1-oxo-2-[(2-
72324-18-6
U.S.
4,242,354
Antitussive
Cough



thienylcarbonyl)thio]propyl]-[CAS]







Stibocaptate

27279-76-1






Stibophen

15489-16-4






Stiibamidine

122-06-5






stiripentol
1-Penten-3-ol, 1-(1,3-benzodioxol-5-yl)-
49763-96-4


Antiepileptic
Epilepsy, 



4,4-dimethyl-[CAS]




general


Streptodornase

37340-82-2






Streptomycin

57-92-1






Streptonicozid

5667-71-0






Streptonigrin

3930-19-6 






Streptozocin

18883-66-4






strontium 
3-Thiopheneacetic acid, 5-
135459-87-9
EP
415850
Osteoporosis 
Osteoporosis


ranelate
[bis(carboxymethyl)amino]-2-carboxy-4-



treatment




cyano-, strontium salt (1:2)-[CAS]







strontium-89 
Strontium chloride (89SrC12) [CAS]
38270-90-5


Analgesic, other
Pain, cancer


chloride








Succimer

304-55-2






Succinimide

123-56-8






Succinylcholine

55-94-7






Succinylcholine

71-27-2






Succinyl-

116-43-8






sulfathiazole








Succisulfone

5934-14-5






Suclofenide

30279-49-3






sucralfate
Aluminium, hexadeca-μ-
54182-58-0
JP
58208233
Antiulcer, 
Ulcer, general



hydroxytetracosahydroxy(μ8-(1,3,4,6-



Formulation, oral, 




tetra-O-sulfo-β-D-fructofuranosyl-Alpha-



other




D-glucopyranoside tetrakis(hydrogen








sulfato)(8-)))hexadeca-[CAS]







sufentanil
Propanamide, N-[4-(methoxymethyl)-1-
56030-54-7
U.S.
3,998,834
Analgesic, other, 
Pain, general



[2-(2-thienyl)ethyl]-4-pipendinyl]-N-



formulation implant




phenyl-[CAS]







sulbactam
4-Thia-1-azabicyclo[3.2.0]heptane-2-
68373-14-8
GB
2000138
Antibiotic, other
Infection, general



carboxylic acid, 3,3-dimethyl-7-oxo-,








4,4-dioxide, (2S-cis)-[CAS]







sulbactam + 

117060-71-6
U.S.
4,234,579
Antibiotic, other
Infection, general


ampicillin








sulbenicillin
4-Thia-1-azabicyclo[3.2.0]heptane-2-
28002-18-8
GB
1289358
Penicillin, injectable
Infection, 



carboxylic acid, 3,3-dimethyl-7-oxo-6-
41744-40-5



pseudomonal



[(phenylsulfoacetyl)amino]-, [2S-








[2Alpha,5Alpha,6a(S*)]]-[CAS]







Sulbentine

350-12-9






sulbutiamine
Propanoic acid, 2-methyl-, dithiobis[3-
3286-46-2


Neurological
Unspecified



[1-[[(4-amino-2-methyl-5-
67-16-3







pyrimidinyl)methyl]formylamino]








ethylidene]-3,1-propanediyl] ester [CAS]







sulconazole
1H-Imidazole, 1-[2-[[(4-
61318-90-9
U.S.
4,055,652
Antifungal
Infection, fungal, 



chlorophenyl)methyl]thio]-2-(2,4-
61318-91-0



general



dichlorophenyl)ethyl]-, (+/−)-[CAS]







Sulesomab

167747-19-5






Sulfabenzamide

127-71-9






Sulfacetamide

144-80-9






Sulfachlor-

80-32-0






pyridazine








Sulfachrysoidine

485-41-6






Sulfacytine

17784-12-2






Sulfadiazine

68-35-9






Sulfadicramide

115-68-4






Sulfadimethoxine

122-11-2






Sulfadoxine

2447-57-6






Sulfaethidole

94-19-9






Sulfaguanidine

57-67-0






Sutfaguanole

27031-08-9






Sulfalene

152-47-6






Sulfaloxic Acid

14376-16-0






Sulfamerazine

127-79-7






Sulfameter

651-06-9






Sulfamethazine

57-68-1 






Sulfamethizole

144-82-1






Sulfamethomidine

3772-76-7






Sulfamethoxazole

723-46-6






Sulfamethoxy-

80-35-3






pyridazine








Sulfametrole

32909-92-5






Sulfamido-

103-12-8






chrysoidine








Sulfamoxole

729-99-7






Sulfanilamide

63-74-1






Sulfanilic Acid

121-57-3






Sulfanilylurea

547-44-4






Sulfaperine

599-88-2






Sulfaphenazole

526-08-9






Sulfaproxyline

116-42-7






Sulfapyrazine

116-44-9






Sutfapyndine

144-83-2






Sulfarside

1134-98-1






Sulfarsphenamine

618-82-6






sulfasalazine
Benzoic acid, 2-hydroxy-5-[[4-[(2-
599-79-1


Formulation, oral, 
Arthritis, 



pyridinylamino)sulfonyl]phenyl]azo]-



enteric-coated
rheumatoid



[CAS]







Sulfasomizole

632-00-8






Sulfasymazine

1984-94-7






Sulfathiazole

72-14-0






Sulfathiourea

51 5-49-1






Sulfinalol

66264-77-5






Sulfinpyrazone

57-96-5






Sulfiram

95-05-6






Sulfisomidine

515-64-0






Sulfisoxazole

127-69-5






Sulfobromo-

71-67-0






phthalein








Sulfonethyl-

76-20-0






methane








Sulfoniazide

3691-81-4






Sulfonmethane

115-24-2






Sulforidazine

14759-06-9






Sulfoxone

144-75-2 






sulindac
cis-5-fluoro-2-methyl-1-[(p-
38194-50-2
U.S.
3,725,548
Anti-inflammatory
Inflammation, 



methylsulfinyl)benzylidene]indene-3-




general



acetic acid







Sulisatin

54935-03-4 






Suliso-

4065-45-6






benzone








Sulmarin

29334-07-4






Sulmazole

73384-60-8 






Suloctidil

54063-56-8 






Sulphan Blue

129-17-9






sulpiride
Benzamide, 5-(aminosulfonyl)-N-[(1-
15676-16-1


Alimentary/Metabolic, 




ethyl-2-pyrrolidinyl)methyl]-2-methoxy-



other




[CAS]







sulprostone
5-Heptenamide, 7-[3-hydroxy-2-(3-
60325-46-4
U.S.
4,024,179
Prostaglandin
Abortion



hydroxy-4-phenoxy-1-butenyl)-5-








oxocyclopentyl]-N-(methylsulfonyl)-,








[1R-[1Alpha(Z),2β(1E,3R*),3Alpha]]-








[CAS]







sultamicillin
4-Thia-1-azabicyclo(3.2.0)heptane-2-
117060-71-6
GB
2044255
Penicillin, oral
Infection, general



carboxylic acid, 6-
76497-13-7







((aminophenylacetyl)amino)-3,3-








dimethyl-7-oxo-, (((3,3-dimethyl-7-oxo-








4-thia-1-azabicyclo(3.2.0)hept-2-








yl)carbonyl)oxy)methyl ester, 5, 5-








dioxide, (2S-








(2.alpha.(2R*,5S*),5,alpha.,6.beta.(S*)))-








[CAS]







Sulthiame

61-56-3

















sultopride
Benzamide, N-((1-ethyl-2-
53583-79-2
FR
M5916
Neuroleptic
Psychosis, general














pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-








methoxy-[CAS]







Sultosilic 

57775-26-5






Acid








sumanirole
4H-Imidazo[4,5,1-ij]quinolin-2(1H)-one,
179386-44-8
WO
9514020
Antiparkinsonian
Parkinson's 



5,6-dihydro-5-(methylamino)-, (5R)-,




disease



(2Z)-2-butenedioate (1:1) [CAS]







sumatriptan
1H-Indole-5-methanesulfonamide, 3-[2
103628-46-2
EP
147107
Antimigraine
Migraine



(dimethylamino)ethyl]-N-methyl-,
103628-48-4







butanedioate (1:1)-[CAS]







SUN-N8075
1-(4-amino-2,3,5-trimethylphenoxy)-3-



Neuroprotective
Infarction, cerebral



{4-[4-(4-fluorobenzyl)phenyl]piperazin-1-








yl}propan-2(s)-ol dimethanesulfonate







suplatast
Sulfonium, (3-[[4-(3-ethoxy-2-
94055-76-2
JP
59167564
Antiasthma
Asthma



hydroxypropoxy)phenyl]amino]-3-








oxopropylldimethyl-, [CAS]







Suprofen

40828-46-4






Suramin

129-46-4






surfactant TA
Beractant [CAS]
108778-82-1
WO
9117766
Lung Surfactant
Respiratory distress








syndrome, general


Suriclone

53813-83-5 






Suxibuzone

27470-51-5 






SYM-1010


U.S.
5,830,998
Antiepileptic
Epilepsy, general


SYM-2081
L-Glutamic acid, 4-methyl-, (4R)-[CAS]
31137-74-3


Analgesic, other
Pain, general


SYM-2207
4-(Aminophenyl)-1-methyl-6,7-



Neuroprotective
Ischaemia, cerebral



(methylenedioxy)-N-butyl-1,2-








dihydrophthalazine-2-carboxamide







Symclosene

87-90-1






Syn-1253
1-cyclopropyl-6-fluoro-8-methoxy-7-[3-



Quinolone 
Infection, 



(4-methyl-1,2,3-triazol-1-yl)pyrrolidin-1-



antibacterial
peritoneum



yl]-4-oxo-1,4-dihydroquinoline 3-








carboxylic acid







Syn-2190
1-Azetidinesulfonic acid, 3-[[(2E)-[[(1,4-
214963-75-4
WO
9847895
Antibacterial, other
Infection, general



dihydro-1,5-dihydroxy-4-oxo-2-








pyridinyl)methoxy]imino]-2-








thienylacetyl]amino]-2-methyl-4-oxo,








(2S,3S)-[CAS]







Syn-2869
3H-1,2,4-Triazol-3-one, 4-(4-(4-
210562-98-4
U.S.
6,153,616
Antifungal
Infection, Aspergillus



((1R,2R)-2-(2,4-difluorophenyl)-2-








hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-








yl)propyl)-1-piperazinyl)phenyl)-2,4-








dihydro-2((4-








(trifluoromethoxy)phenyl)methyl)-








[CAS]







Synephrine

94-07-5






Syrosingopine

84-36-6






T-1095
1-Propanone, 3-(5-benzofuranyl)-1-(2-
209746-59-8
EP
850948
Antidiabetic
Diabetes, general



hydroxy-6-((6-O-methoxycarbonyl)-B-D-








glucopyranosyl)oxy)-4-methylphenyl-








[CAS]







T-1249
L-Phenylalaninamide, N-acetyl-L-
251562-00-2
WO
9959615
Antiviral, anti-HIV
Infection, HIV/AIDS



tryptophyl-L-glutaminyl-L-Alpha-








glutamyl-L-tryptophyl-L-Alpha-glutamyl-








L-glutaminyl-L-lysyl-L-isoleucyl-L-








threonyl-L-alanyl-L-leucyl-L-leucyl-L-








Alpha-glutamyt-L-glutaminyl-L-alanyl-L-








glutaminyl-L-isoleucyl-L-glutaminyl-L-








glutaminyl-L-Alpha-glutamyl-L-lysyl-L-








Alpha-glutamyl-asparaginyl-L-tyrosyl-L-








Alpha-glutamyl-L-leucyl-L-glutaminyl-L-








lysyl-L-leucyl-L-Alpha-aspartyl-L-lysyl-I-








trytophyl-L-ananyl-L-seryl-L-leucyl-L-








trytophyl-L-Alpha-glutamyl-L-tryptophyl








[CAS]







T-3912
1-cyclopropyl-8-methyl-7-[5-methyl-6-



Quinolone 
Infection, 



(methylamino)-3-pyridinyl]-4-oxo-1,4-



antibacterial
dermatological



dihydro-3-quinolinecarboxylic acid







T-588
Benzo(b)thiophene-5-methanol, Alpha-
142935-03-3
EP
565965
Cognition enhancer
Alzheimer's 



((2-(diethylamino)ethoxy)methyl)-,




disease



hydrochloride; (R)-[CAS]







T-67
Benzenesulfonamide, 2,3,4,5,6-
195533-53-0


Anticancer, other
Cancer, liver



pentafluoro-N-(3-fluoro-4-








methoxyphenyl)-[CAS]







T-82


U.S.
5,190,951
Cognition enhancer
Alzheimer's liver


TA-2005
2(1H)-Quinolinone, 8-hydroxy-5-[1-
137888-11-0
U.S.
4,579,854
Antiasthma
Asthma



hydroxy-2-[[2-(4-methoxyphenyl)-1-








methylethyl]amino]ethyl]-,








monohydrochloride, [R-(R*,R*)]-[CAS]







TA-2005
2(1H)-Quinolinone, 8-hydraxy-5-[1-

WO
189480
Formulation, inhalable, 
Asthma



hydraxy-2-[[2-(4-methoxyphenyl)-1-



solution




methylethyl]amina]ethyl]-,








manahydrochlaride, [R-(R*,R*)]-[CAS]







TA-993
1,5-Benzathiazepin-4(5H)-one, 3-
122024-98-0
JP
01045376
Antithrombotic
Peripheral vascular 



(acetyloxy)-5-[2-(dimethylamino)ethyl]-




disease



2,3-dihydra-8-methyl-2-(4-








methylphenyl)-, (2R,3R)-rel-(−)-, (2Z)-2-








butenedioate [CAS]







tabimorelin
(R)-Alpha-[(E)-5-Amino-N,5-dimethyl-2-
193079-69-5


Releasing hormones
Growth hormone 



hexenamido]-N-methyl-N-[(R)-Alpha-




deficiency



(methylcarbamoyl)phenethyl]-2-








napthaleneprapianamide
170851-70-4






tacalcitol
9,10-Secachalesta-5,7,10(19)-triene-
57333-96-7
EP
129003
Antipsoriasis
Keratosis



1,3,24-trial, (1Alpha,3β,5Z,7E,24R)-
93129-94-3







[CAS]







tacedinaline
Benzamide, 4-(acetylamina)-N-(2-
112522-64-2
DE
3613571
Anticancer, other
Cancer, pancreatic



aminophenyl)-[CAS]







tacrine
9-Acridinamine, 1,2,3,4-tetrahydro-
1684-40-8
EP
332147
Cognition enhancer
Alzheimer'disease



[CAS]
321-64-2






Tacralimus

104987-11-3






tadalafil
Pyrazina(1′,2′:1,6)pyrida(3,4-
171596-29-5
U.S.
6,143,746
Male sexual 
Impotence



b)indole1,4-dione, 6-(1,3-benzadiaxal-5



dysfunction




yl)-2,3,6,7,12,12a-hexahydro-2-methyl-,








(6R-trans) [CAS]







tafenoquine
1,4-Pentanediamine, N4-[2,6-
106635-80-7
U.S.
4,617,394
Antimalarial
Infection, malaria



dimethaxy-4-methyl-5-[3-
106635-81-8







(trifluaramethyl)phenoxy]-8-quinalinyl]-
80065-55-0







[CAS]







taflupaside

179067-42-6
WO
9612727
Anticancer, other
Cancer, general


TAK-375
(S)-N-[2-(1,6,7,8-Tetrahydro-2H-indeno



Hypnotic/Sedative
Insomnia



[5,4-bifuran-8-yl)]propionamide







TAK-427
2-[6-[[3-[4-(Diphenylmethoxy)-



Antipruritic/inflamm, 
Eczema, atopic



piperidino]imidazo[1,2-b]pyridazin-2-yl-



allergic




2-methylpropionic acid dihydrate







TAK-559
(E)-4-{4-(5-Methyl-2-phenyl-13-oxazol-



Antidiabetic
Diabetes, general



4-yl)methoxy]benzyloxylmino}-4-








phenylbutyric acid







Taka-

9001-19-8






Diastase








talampanel
7H-1,3-Dioxolo[4,5-
161832-65-1
U.S.
5,639,751
Antiepileptic
Epilepsy, general



h][2,3]benzodiazepine,7-acetyl-5-(4-








aminophenyl)-8,9-dihydro-8-methyl-,








(8R)-[CAS]







Talampicillin

47747-56-8






talaporfin
N-[[(2S,3S)-18-Carboxy-2-(2-carboxy-
220201-34-3


Radia/chemosensitizer
Cancer, lung, general



ethyl)-13-ethyl-2,3-dihydro-3,7,12,17-








tetramethyl-8-vinyl porphyrin-20-








yl]acetyl]-L-aspartic acid







Talastine

16188-61-7






Talbutal

115-44-6






Talinolol

57460-41-0






talipexole
4H-Thiazolo[4,5-d]azepin-2-amine,
101626-70-4
DE
3503963
Antiparkinsonian
Schizophrenia



5,6,7,8-tetrahydro-6-(2-propenyl)-
36085-73-1







[CAS]







talnetant
4-Quinolinecarboxamide, 3-hydroxy-2-
174636-32-9
WO
9532948
GI inflammatory/bowel 
Irritable bowel 



phenyl-N-[(1S)-1-phenylpropyl]-[CAS]



disorders
syndrome


talniflumate
3-Pyridinecarboxylic acid, 2-[[3-
66898-62-2
BE
858864
Anti-inflammatory
Inflammation, ocular



(trifluoromethyl)phenyl]amino]-, 1,3-








dihydro-3-oxo-1-isobenzofuranyl ester








[CAS]







taltirelin
L-Prolinamide, N-[(hexahydro-1-methyl
103300-74-9
JP
61033197
Neurological
Dyskinesia, general



2,6-dioxo-4-pynmidinyl)carbonyl]-L-








histidyl-, (S)-[CAS]







tamoxifen
Ethanamine, 2-[4-(1,2-diphenyl-1-
10540-29-1
U.S.
4,536,516
Anticancer, hormonal




butenyl)phenoxy]-N,N-dimethyl-, (Z)








[CAS]







tamsulosin
Benzenesulfonamide, 5-12-[[2-(2-
106133-20-4
EP
34432
Prostate disorders
Benign prostatic 



ethoxyphenoxy)ethyl]amino]propyl]-2-
80223-99-0



hyperplasia



methoxy-, (R)-[CAS]







tandospirone
4,7-Methano-1H-isoindole-1,3(2H)-
112457-95-1
EP
82402
Anxiolytic
Anxiety, general



dione, hexahydro-2-[4-[4-(2-pyrimidinyl)
87760-53-0







1-piperazinyl]butyl]-,








(3aAlpha,4β,7β,7aAlpha)-, 2-hydroxy-








1,2,3-propanetricarboxylate (1:1) [CAS]







Tannoform

9010-29-1






Taprostene

108945-35-3






tariquidar
3-Quinolinecarboxamide, N-(2-[[[4-[2-
206873-63-4
WO
9817648
Radio/
Cancer, lung, 



(3,4-dihydro-6,7-dimethoxy-2(1H)-



chemosensitizer
non-small cell



isoquinolinyl)ethyl]phenyl]amino]carbon








yl]-4,5-dimethoxyphenyl]-[CAS]







TAS-103
6-[[2-(Dimethyl-amino)ethyl]amino]-3-
174634-09-4
WO
9532187
Anticancer, other
Cancer, lung, 



hydroxy-7H-indeno[2,1-c]quinolin-7-




non-small cell



one dihydrochloride







Tasosartan

145733-36-4






Taurocholic 

81-24-3






Acid 








Taurolidine

19388-87-5






tazanolast
Acetic acid, oxo[[3-(1H-tetrazol-5-
82989-25-1
U.S.
4,778,816
Antiasthma




yl)phenyl]amino]-, butyl ester [CAS]







tazarotene
3-Pyridinecarboxylic acid, 6-[(3,4-
118292-40-3
EP
284288
Antipsoriasis
Psoriasis



dihydro-4,4-dimethyl-2H-1-








benzothiopyran-6-yl)ethynyl]-, ethyl








ester [CAS]







Tazobactam

89786-04-9






tazobactam + 


JP
58225091
Antibiotic, other
Infection, general


piperacillin








TBC-3711

374680-51-0


Cardiovascular
Heart failure


TCH-346
N-Methyl-N-propargyl-10-aminomethyl-



Neuroprotective
Amyotrophic lateral 



dibenzo(b,f)oxepin




sclerosis


tebipenem
5-Hexenoic acid, 4-hydroxy-, polymer
82200-24-6


Beta-lactam antibiotic
Infection, 



with 4-ethenyl-1H-imidazole [CAS]




streptococcal


tecadenoson
Adenosine, N-[(3R)-tetrahydro-3-
204512-90-3
WO
9808855
Antiarrhythymic
Tachycardia,



furanyl]-[CAS]




supraventricular


tecastemizole
1H-Benzimidazol-2-amine, 1-((4-
75970-99-9
U.S.
4,219,559
Antiallergic, non-
Rhinitis, allergic, 



fluorophenyl)methyl)-N-4-pipendinyl-



asthma
seasonal



[CAS]







Technetium 

121281-41-2






99mTc Bicisate








Technetium 

125224-05-7;






99mTc

104348-91-6 






Mertiatide








Technetium 

109581-73-9






99mTc








Sestamibi








Technetium 

104716-22-5






99mTc








Teboroxime








Teclothiazide

4267-5-4 






Teclozan

5560-78-1 






tedisamil
Spirolcyclopentane-1,9-
90961-53-8
EP
102833
Antiarrhythmic
Fibrillation, atrial



[3,7]diazabicyclo[3.3.1]nonane], 3′,7′-








bis(cyclopropylmethyl)-[CAS]







Teflurane

124-72-1 






tegafur
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-
17902-23-7
GB
1168391
Anticancer, 
Cancer, general



(tetrahydro-2-furanyl)-[CAS]



antimetabolite



tegafur + uracil
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-
74578-38-4
EP
224885
Anticancer, 
Cancer, breast



(tetrahydro-2-furanyl)-, mixt. with



antimetabolite




2,4(1H,3H)-pyrimidinedione-[CAS]







tegaserod
Hydrazinecarboximidamide, 2-((5-
189188-57-6


GI inflammatory/bowel 
Irritable bowel 



methoxy-1H-indol-3-yl)methylene)-N-
145158-71-0


disorders
syndrome



pentyl-, (Z)-2-butenedioate [CAS]







Teicoplanin

61036-64-4






telbivudine
β-L-2-deoxythymidine
3424-98-4


Antiviral, other
Infection, 


Telenzepine

80880-90-6



hepatitis-B virus


telithromycin
3-De((2,6-dideoxy-3-C-methyl-3-O-
191114-48-4
EP
680967
Macrolide antibiotic
Infection, respitory 



methyl-Alpha-L-ribo-




tract, general



hexopyranosyl)oxy)-11,12-dideoxy-6-O-








methyl-3-oxo-12,11-(oxycarbonyl((4-(4-








(3-pyridinyl)-1H-imidazol-1-








yl)butyl)imino))-[CAS]







telmesteine
3,4-Thiazolidinedicarboxylic acid, 3-
122946-43-4


COPD treatment
Bronchitis, chronic



ethyl ester, (R)-[CAS]







telmisartan
(1,1-Biphenyl)-2-carboxylic acid, 4′-
144701-48-4
EP
502314
Antihypertensive, renin 
Hypertension, 



((1,4-dimethyl-2′-propyl(2,6′-bi-1H-



system
general



benzimidazol)-1′-yl)methyl)-[CAS]







telomerase 


WO
9941261
Anticancer, other
Cancer, general


inhibs








temazepam
7-chloro-1,3-dihydro-3-hydroxy-1-
846-50-4
U.S.
3197467 
Hypnotic/Sedative
Insomnia



methyl-5-phenyl-2H-1,4-benzodiazepin-








2-one







temiverine
Benzeneacetic acid, Alpha-cyclohexyl-
129927-33-9
GB
2222828
Urological
Pollakisuria



Alpha-hydroxy-, 4-(diethylamino)-1,1-








dimethyl-2-butynyl ester, [CAS]







temocapril
1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-
102090-90-4
U.S.
4,495,188
Antihypertensive, renin 
Hypertension, 



(ethoxycarbonyl)-3-
110221-44-8


system
general



phenylpropyl]amino]tetrahydro-5-oxo-2-
111902-57-9







(2-thienyl)-, [2S-[2Alpha,6β(R*)]]-








[CAS]







Temocillin

66148-78-5






temoporfin
Phenol, 3,3′,3′′,3′′′-(2,3-dihydro-
122341-38-2
EP
337601
Radio/
Cancer, head and 



21H,23H-porphine-5,10,15,20-



chemosensitizer
neck



tetrayl)tetrakis-[CAS]







temozolomide
Imidazo[5,1-d]-1,2,3,5-tetrazine-8-
85622-93-1
DE
3231255
Anticancer, 
Cancer, brain, general



carboxamide, 3,4-dihydro-3-methyl-4-



alkylating




oxo-[CAS]







tenatoprazole
1H-Imidazo(4,5-b)pyndine, 5-methoxy-
113712-98-4
U.S.
4,808,596
Antiulcer
Ulcer, gastric



2-(((4-methoxy-3,5-dimethyl-2-








pyridinyl)methyl)sulfinyl)-[CAS]







Tenecteplase

191588-94-0






Tenidap

120210-48-2






teniposide
Furo[3′,4′:6,7]naphthol2,3-d]-1,3-dioxol
29767-20-2
U.S.
3524844
Anticancer, other
Cancer, lymphoma, 



6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-




non-Hodgkin's



hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-








O-(2-thienylmethylene)-β-D-








glucopyranosylloxy]-, [5R-








[5Alpha,5aβ,8aAlpha,9β(R*)]]-[CAS]







tenofovir
Phosphonic acid, (((1R)-2-(6-amino-9H-
147127-20-6


Antiviral, anti-HIV
Infection, HIV/AIDS



purin-9-yl)-1-methylethoxy)methyl)-








[CAS]







tenofovir 
2,4,6,8-tetraoxa-5-phosphanonanedioic
202138-50-9


Antiviral, anti-HIV
Infection, HIV/AIDS


disoproxil
acid, 5-(2-(6-amino-9H-purin-9-yl)-1-








methylethoxymethyl) bis(1-








methylethyl)ester, 5-oxide (R)-, (E)-2-








butenedioate







Tenonitrozole

3810-35-3






tenoxicam
2H-Thieno[2,3-e]-1,2-thiazine-3-
59804-37-4
GB
1519811
Antiarthritic, other




carboxamide, 4-hydroxy-2-methyl-N-2-








pyridinyl-, 1,1-dioxide [CAS]







Tenuazonic 

610-88-8






Acid








teprenone
5,9,13,1 7-Nonadecatetraen-2-one,
3796-63-2


Antiulcer




6,10,14,18-tetramethyl-[CAS]
6809-52-5






terazosin
Piperazine, 1-(4-amino-6,7-dimethoxy-
63074-08-8
U.S.
4,112,097
Antihypertensive, 
Hypertension, general



2-quinazolinyl)-4-[(tetrahydro-2-
63590-64-7


adrenergic




furanyl)carbonyl]-[CAS]
70024-40-7






terbinafine
1-Naphthalenemethanamine, N-(6,6-
78628-80-5
EP
24587
Antifungal
Infection, 



dimethyl-2-hepten-4-ynyl)-N-methyl-,
91161-71-6



dermatological



(E)-[CAS]







terbutaline
1,3-Benzenediol, 5-[2-[(1,1-
23031-25-6


Formulation, mucosal, 
Dysmenorrhoea



dimethylethyl)amino]-1-hydroxyethyl]-



topical




[CAS]







terconazole
Piperazine, 1-[4-[[2-(2,4-
67915-31-5
U.S.
4,358,449
Antifungal
Vaginitis



dichlorophenyl)-2-(1H-1,2,4-triazol-1-








ylmethyl)-1,3-dioxolan-4-








yl]methoxy]phenyl]-4-(1-methylethyl)-,








cis-[CAS]







terfenadine
1-Pipendinebutanol, Alpha-[4-(1,1-
50679-08-8
U.S.
3,878,217
Antiallergic, non-




dimethylethyl)phenyl]-4-



asthma




(hydroxydiphenylmethyl)-[CAS]







terguride
Urea, N,N-diethyl-N-[(8Alpha)-6-
37686-84-3
EP
159522
Antiprolactin
Hyperprolactinaemia



methylergolin-8-yl]-[CAS]







Terlipressin

14636-12-5 






Terodiline

15793-40-5






Terofenamate

29098-15-5






Terpin

80-53-5






tertatolol
2-Propanol, 1-[(3,4-dihydro-2H-1-
33580-30-2
GB
1308191
Antihypertensive, 
Hypertension, 



benzothiopyran-8-yl)oxy]-3-[(1,1-
83688-84-0


adrenergic
general



dimethylethyl)amino]-, hydrochloride,
34784-64-0







(+\−)-[CAS]







tert-Pentyl 

75-85-4






Alcohol








tesaglitazar
(2S)-2-ethoxy-3-[4-[2-[4-



Antidiabetic
Diabetes, Type II



[(methylsulfonyl)oxy]phenyl]ethoxy]








phenyl] propanoic acid







tesmilifene
Ethanamine, N,N-Diethyl-2-(4-
92981-78-7


Radio/chemosensitizer
Cancer, breast



(phenylmethyl)phenoxy)-[CAS]







Testolactone

968-93-4






Testosterone
androst-4-en-3-one, 17-hydroxy-, (17β)-
58-22-0 


Formulation, 
Hormone 



[CAS]
5949-44-0


transdermal, systemic
replacement therapy


tetrabamate

60763-47-5
DE 
2748794
Anxiolytic
Addictioin, alcohol


Tetrabarbital

76-23-3






Tetrabenazine

58-46-8






Tetracaine

136-47-0






Tetrachloro-

127-18-4






ethylene








tetracine
Benzoic acid, 4-(butylamino)-, 2-
94-24-6


Formulation, 
Pain, general



(dimethylamino)ethyl ester [CAS]



transdermal, systemic



tetracycline
2-Naphthacenecarboxamide, 4-
60-54-8


Formulation, oral, 
Infection, oral



(dimethylamino)-1,4,4a,5,5a,6,11,12a-



other




octahydro-3,6,10,12,12a-pentahydroxy-








6-methyl-1,11-dioxo-, [4S-








(4Alpha,4aAlpha,5aAlpha,6β,12aAlpha)]-








[CAS]







Tetrahy-

84-22-0






drozoline








Tetrandrine

518-34-3






Tetrantoin

52094-70-9 






Tetrazepam

10379-14-3 






Tetrofosmin

127502-06-1 






tetroxoprim
2,4-Pyrimidinediamine, 5-[[3,5-
53808-87-0
U.S.
3,992,379
Trimethoprim and 
Infection, general



dimethoxy-4-(2-
74515-38-1


analogues




methoxyethoxy)phenyl]methyl]-[CAS]







Tevenel ®

4302-95-8 






tezacitabine
Cytidine, 2′-deoxy-2′-(fluoromethylene)-,
130306-02-4
U.S.
5,616,702
Anticancer, 
Cancer, general



(2E)-[CAS]



antimetabolite



tezosentan
2-Pyridinesulfonamide, N-(6-(2-
180384-57-0


Cardiostimulant
Oedema, general



hydroxyethoxy)-5-(2-methoxyphenoxy)-








2-(2-(1H-tetrazol-5-yl)-4-pyridinyl)-4-








pyrimidinyl)-5-(1-methylethyl)-[CAS]







thalidomide
1H-Isoindole-1,3(2H)-dione, 2-(2,6-
50-35-1


Dermatological
Infection, 



dioxo-3-piperidinyl)-[CAS]




dermatological


Thenaldine

86-12-4






Thenyldiamine

91-79-2






Theobromine

83-67-0






Theofibrate

54504-70-0






theophylline
1H-Purine-2,6-dione, 3,7-dihydro-1,3-
58-55-9


Formulation, modified-
Asthma



dimethyl-[CAS]
5967-84-0


release, other



Thiabendazole

148-79-8 






Thiacetazone

104-06-3 






thiacymsenne
Carbamic acid, [4-(1-
145209-51-4


Cognition enhancer
Alzheimer's disease



methylethyl)phenyl]-, (3aS,8aS)-








3,3a,8,8a-tetrahydro-3a,8-dimethyl-2H-








thieno[2,3-b]indol-5-yl ester [CAS]







Thialbarbital

467-36-7






Thiamine

59-43-8






Thiamine

154-87-0






Thiamine

67-16-3






Thiamiprine

5581-52-2






Thiamphenicol

15318-45-3






Thiamylal

77-27-0






Thiazesim

5845-26-1 






Thiazinamium

58-34-4






Thiazolino-

54749-86-9






butazone








Thiazolsulfone

473-30-3 






Thibenzazoline

6028-35-9 






Thiethylperazine

1420-55-9






Thimerfonate

5964249






Thimerosal

54-64-8






Thiobarbital

77-32-7 






Thiobutabarbital

2095-57-0






Thiocarbamizine

91-71-4






Thiocarbarsone

120-02-5






Thiocolchicine

2730-71-4






Thiocresol

26445-03-4






Thioctic Acid

62-46-4 






Thioglycerol

96-27-5






Thioguanine

154-42-7






Thioimreg
L-Thiotyrosinyl-glycinyl-glycine



Anticancer, 
Cancer, general







immunological



Thiopental

71-73-8






Thiopropazate

84-06-0






Thioproperazine

316-81-4






Thioridazine

50-52-2






Thiothixene

5591-45-7






Thiovir
Thiophosphonoformic acid



Antiviral, anti-HIV
Infection, HIV/AIDS


Thiphenamil

82-99-5






Thiram

137-26-8






Thonzylamine

63-56-9






Thozalinone

655-05-0






Thromboplastin

9035-58-9






Thurfyl 

70-19-9






Nicotinate








thymectacin


U.S.
6,245,750
Anticancer, other
Cancer, colorectal


Thymol

89-83-8






Thymopentin

69558-55-0 






Thymyl N-

578-20-1






Isoamylcarbamate








Thyropropic Acid

51-26-3






Thyroxine

51-48-9 






Tiadenoi

6964-20-1 






tiagabine
3-Piperidinecarboxylic acid, 1-[4,4-bis(3
115103-54-3
WO
8700171
Antiepileptic
Epilepsy, general



methyl-2-thienyl)-3-butenyl]-, (R)








[CAS]







Tiamenidine

31428-61-2






tianeptine
Heptanoic acid, 7-[(3-chloro-6,11-
72797-41-2
GB
1269551
Antidepressant
Depression, general



dihydro-6-
66981-73-5







methyldibenzo[c,f][1,2]thiazepin-11-








yl)amino]-, 5,5-dioxide [CAS]







tiapride
Benzamide, N-[2-(diethylamino)ethyl]-2-
51012-32-9
GB
1394563
Neuroleptic




methoxy-5-(methylsulfonyl)-[CAS]







tiaprofenic acid
2-Thiopheneacetic acid, 5-benzoyl-
33005-95-7
GB
1331505
Antiarthritic, other




Alpha-methyl-[CAS]







Tiaramide

32527-55-2






tiazofurin
4-Thiazolecarboxamide, 2-β-D-
60084-10-8
EP 
54432 
Anticancer, 
Cancer, leukaemia, 



ribofuranosyl-[CAS]



antimetabolite
chronic








myelogenous


Tibezonium

54663-47-7






tibolone
19-Norpregn-5(10)-en-20-yn-3-one, 17-
5630-53-5
EP 
389035 
Menopausal disorders
Hormone replacement



hydroxy-7-methyl-, (7Alpha,17Alpha)-




therapy



[CAS]







Ticarcillin

34787-01-4






ticlopidine
Thieno[3,2-c]pyridine, 5-[(2-
53885-35-1
GB
1554424
Antithrombotic




chlorophenyl)methyl]-4,5,6,7-tetrahydro-
55142-85-3







[CAS]







Ticrynafen

40180-04-9






tiemonium
4-(3-hydroxy-3-phenyl-3-thien-2-yl-
6252-92-2 


Antispasmodic




propyl)-4-methylmorpholinium
144-12-7 






tigecycline
2-Naphthacenecarboxamide, 4,7-
220620-09-7
EP
582829
Tetracycline
Infection, general



bis(dimethylamino)-9-[[[(1,1-








dimethylethyl)amino]acetyl]amino]-








1,4,4a,5,5a,6,11,12a-octahydro-








3,10,12,12a-tetrahydroxy-1,11-dioxo-,








(4S,4aS,5aR,12aS)-[CAS]







Tigemonam

102507-71-1






Tigloidine

495-83-0






Tilidine

20380-58-9






Tilisolol

85136-71-6






tilmacoxib
Benzenesulfonamide, 4-(4-cyclohexyl-2
180200-68-4
WO
9619463
Alimentary/Metabolic, 
Polyp



methyl-5-oxazolyl)-2-fluoro-[CAS]



other



tiludronic 
Phosphonic acid, [[(4-
89987-06-4
EP
100718
Osteoporosis treatment
Paget's disease


acid
chlorophenyl)thio]methylene]bis-[CAS]







Timentin

86482-18-0


Antibiotic, other
Infection, general


timepidium
Piperidinium, 3-(di-2-thienylmethylene)-
35035-05-3
GB
1358446
Antispasmodic




5-methoxy-1,1-dimethyl-, [CAS]







Timiperone

57648-21-2






timolol
(−)-1-(t-butylamino)-3-[(4-morpholino-
26839-75-8
GB
1253709
Antihypertensive, 




1,2,5-thiadiazol-3-yl)oxy]-2-
26921-17-5


adrenergic




propanolmaleate (1:1) salt



antiglaucoma



Timonacic

444-27-9






Tin Ethyl 

113471-15-1






Etiopurpurin








tinazoline
1H-Indole, 3-[(4,5-dihydro-1H-imidazol-
62882-99-9
U.S.
3,376,311
Vasodilator, peripheral




2-yl)thio]-[CAS]







Tinidazole

19387-91-8






Tinondine

24237-54-5






Tiocarlide

910-86-1






Tioclomarol

22619-35-8






tioconazole
1H-Imidazole, 1-[2-[(2-chloro-3-
61675-64-7
U.S.
4,062,966
Antifungal
Infection, fungal, 



thienyl)methoxy]-2-(2,4-
65899-73-2



general



dichlorophenyl)ethyl]-[CAS]







tiopronin
Glycine, N-(2-mercapto-1-oxopropyl)-
1953-02-2
U.S.
3,246,025
Urological
Homocystinuria



[CAS]







tiotropium
3-Oxa-9-
136310-93-5
EP
418716
COPD treatment
Chronic obstructive



azoniatricyclo(3.3.1.02,4)nonane, 7-




pulmonary disease



((hydroxydi-2-thienylacetyl)oxy)-9,9-








dimethyl-, [CAS]







Tioxolone

4991-65-5






Tipepidine

5169-78-8






tipifarnib
2(1H)-Quinolone, 6-(amino(4-
192185-68-5
WO
9716443
Anticancer, other
Cancer, breast



chlorophenyl)(1-methyl-1H-imidazol-5-
192185-72-1







yl)methyl)-4-(3-chlorophenyl)-1-methyl








[CAS]







tipranavir
N-[3-[1(R)-[4-Hydroxy-2-oxo-6(R)-(2-
174484-41-4


Antiviral, anti-HIV
Infection, HIV/AIDS



phenylethyl)-6-propyl-5,6-dihydro-2H-








pyran-3-yl]propyl]phenyl]-5-








(trifluoromethyl)pyridine-2-sulfonamide







tiquizium
2H-Quinolizinium, 3-(di-2-
71731-58-3
U.S.
4,205,074
Antispasmodic




thienylmethylene)octahydro-5-methyl-,








[CAS]







tirapazamine
1,2,4-Benzotriazin-3-amine, 1,4-dioxide
20028-80-2
DE
2204574
Radio/
Cancer, lung, 



[CAS]
27314-97-2


chemosensitizer
non-small cell




5424-06-6






Tiratricol

51-24-1






tinlazad
Pregna-1,4,9(11)-triene-3,20-dione, 21-
110101-65-0
WO
8701706
Neuroprotective
Haemorrhage, 



[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-
110101-67-2



subarachnoid



piperazinyl]-16-methyl-, (16Alpha)-,
110101-66-1







[CAS]







tirofiban
L-Tyrosine, N-(butylsulfonyl)-O-[4-(4-
142373-60-2
EP
478363
Antithrombotic
Infarction, myocardial



piperidinyl)butyl]-, [CAS]
144494-65-5






tiropramide
Benzenepropanamide, Alpha-
55837-29-1
DE
2503992
Antispasmodic
Muscle spasm, 



(benzoylamino)-4-[2-




general



(diethylamino)ethoxy]-N,N-dipropyl-, 








(+\−)-[CAS]







Titanium 

13825-74-6






Sulfate








tixocortol
Pregn-4-ene-3,20-dione, 21-[(2,2-
55560-96-8
GB
1475795
Antiallergic, 
Rhinitis, allergic, 



dimethyl-1-oxopropyl)thio]-11,17-
61951-99-3


non-asthma, 
general



dihydroxy-, (11β)-[CAS]



mucosal, topical



tizanidine
2,1,3-Benzothiadiazol-4-amine, 5-
51322-75-9
GB
1429926
Muscle relaxant
Spastic paralysis



chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-








[CAS]







TLK-199
Glycine, L-Gamma-glutamyl-S-
168682-53-9
U.S.
5,679,643
Immunostimulant, 
Myelodysplastic 



(phenylmethyl)-L-cysteinyl-2-phenyl-,



other
syndrome



diethyl ester, (2R)-[CAS]







TLK-286
Glycine, L-Gamma-glutamyl-3-[[2-
158382-37-7
U.S.
5,545,621
Anticancer, other
Cancer, ovarian



([bis[bis(2-








chloroethyl)amino]phosphinyl]oxy)ethyl]








sulfonyl]-L-alanyl-2-phenyl-, (2R)-








[CAS]







TNF-β, 


RU
2035185
Anticancer, 
Cancer, general


analogue




immunological



TNP-470

129298-91-5






TO-186
Pregna-1,4-diene-3,20-dione, 9-fluoro-
5534-02-1


Antipruritic/inflamm, 




11β,17,21-trihydroxy-16.beta.-methyl-,



allergic




17-butyrate 21-propionate [CAS]







tobramycin
O-3-amino-3-deoxy-Alpha-D-
32986-56-4


Formulation, inhalable, 
Infection, respiratory 



glucopyranosyl-(1,6)-O-(2,6-diamino-



topical
tract, general



2,3,6-trideoxy-Alpha-D-ribo-








hexopyranosyl-(1-4)-2-deoxy-[CAS]







tocainide
Propanamide, 2-amino-N-(2,6-
41708-72-9
U.S.
4,218,477
Antiarrhythmic
Fibrillation, 



dimethylphenyl)-[CAS]




ventricular


Tocamphyl

5634-42-4






tocladesine
8-Chloroadenosine 3′5′-cyclic
41941-56-4


Anticancer, other
Cancer, colorectal



phosphate







Tocoretinate

40516-48-1






Todralazine

14679-73-3






Tofenacin

15301-93-6






tofimilast
5H-Pyrazolo[3,4-c]-1,2,4-triazolo[4,3-
185954-27-2


Antiasthma
Asthma



a]pyridine,9-cyclopentyl-7-ethyl-6,9-








dihydro-3-(2-thienyl)-







tofisopam
5H-2,3-Benzodiazepine, 1-(3,4-
22345-47-7
GB
1334271
Anxiolytic
Anxiety, general



dimethoxyphenyl)-5-ethyl-7,8-








dimethoxy-4-methyl-[CAS]







Tolazamide

1156-19-0






Tolazoline

59-98-3






Tolbutamide

64-77-7






tolcapone
Methanone, (3,4-dihydroxy-5-
134308-13-7
EP
237929
Antiparkinsonian
Parkinson's disease



nitrophenyl)(4-methylphenyl)-[CAS]







tolciclate
Carbamothioic acid, methyl(3-
50838-36-3
GB
1364407
Antifungal
Infection, 



methylphenyl)-, O-(1,2,3,4-tetrahydro-




dermatological



1,4-methanonaphthalen-6-yl) ester








[CAS]







Tolcyclamide

664-95-9






tolevamer
Benzenesulfonic acid, 4-ethenyl-,
28038-50-8


Antibacterial, other
Infection, 



homopolymer,




Clostridium,








general


tolfenamic acid
Benzoic acid, 2-[(3-chloro-2-
13710-19-5
DE
1543295
Anti-inflammatory
Inflammation, 



methylphenyl)amino]-[CAS]




general


Tolindate

27877-51-6






Toliprolol

2933-94-0






Tolmetin

26171-23-3






Tolnaftate

2398-96-1






Tolonidine

4201-22-3






Tolonium

92-31-9






toloxatone
2-Oxazolidinone, 5-(hydroxymethyl)-3-
29218-27-7
GB
1250538
Antidepressant




(3-methylphenyl)-[CAS]







Tolperisone

728-88-1






Tolpropamine

5632-44-0






Tolrestat

82964-04-3






tolserine
Carbamic acid, (2-methylphenyl)-,
145209-30-9


Cognition enhancer
Alzheimer's 



(3aS,8aR)-1,2,3,3a,8,8a-hexahydro-




disease



1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl








ester [CAS]







tolterodine
Phenol, 2-(3-(bis(1-methylethyl)amino)-
124937-51-5
EP
325571
Urological
Incontinence



1-phenylpropyl)-4-methyl-, (R)-[CAS]







tolvaptan
Benzamide, N-[4-[(7-chloro-2,3,4,5-
150683-30-0
EP
450097
Cardiovascular
Heart failure



tetrahydro-5-hydroxy-1H-1-benzazepin-








1-yl)carbonyl]-3-methylphenyl]-2-








methyl-[CAS]







Tolycaine

3686-58-6






Topiramate
Beta-D-Fructopyranose, 2,3:4,5-bis-O-
97240-79-4
EP
533483
Antiepileptic
Epilepsy, 



(1-methylethylidene)-, sulfamate [CAS]




generalized, tonic-








clonic


topoisomerase 


U.S.
5,733,880
Anticancer, other
Cancer, general


inhibitors








topotecan
1H-Pyrano[3′,4′:6,7]indolizino[1,2-
123948-87-8
EP
321122
Anticancer, other
Cancer, ovarian



b]quinoline-3,14(4H, 12H)-dione, 9-








[(dimethylamino)methyl]-4-ethyl-4,10-








dihydroxy-, (S)-[CAS]







torasemide
3-Pyridinesulfonamide, N-[[(1-
56211-40-6
U.S.
4,018,929
Antihypertertensive, 
Hypertension, 



methylethyl)amino]carbonyl]-4-[(3-



diuretic
general



methylphenyl)amino]-[CAS]







torcetrapib
ethyl (2R,4S)-4-[[3,5-
262352-17-0


Hypolipaemic/
Atherosclerosis



bis(trifluoromethyl)



Antiatherosclerosis




benzyl](methoxycarbonyl)amino]-2-








ethyl-6-(trifluoromethyl)-3,4-








dihydroquinoline-1(2H)-carboxylate







torcitabine
β-L-2′Deoxycytidine



Antiviral, other
Infection, 








hepatitis-B virus


toremifene
Ethanamine, 2-[4-(4-chloro-1,2-
89778-26-7
EP
95875
Anticancer, 
Cancer, breast



diphenyl-1-butenyl)phenoxy]-N,N-
89778-27-8


hormonal




dimethyl-, (Z)-[CAS]







Torsemide

56211-40-6






Tositumomab

208921-02-2






tosufloxacin
1,8-Naphthyridine-3-carboxytic acid, 7-
100490-36-6
U.S.
4,704,459
Quinolone 
Infection, urinary 



(3-amino-1-pyrrolidinyl)-1-(2,4-
115964-29-9


antibacterial
tract



difluorophenyl)-6-fluoro-1,4-dihydro-4-








oxo-, [CAS]







tramadol
Cyclohexanol, 2-
27203-92-5


Analgesic, other
Pain, general



[(dimethylamino)methyl]-1-(3-
36282-47-0







methoxyphenyl)-, cis-(+/−)-[CAS]







Tramazoline

1082-57-1






trandolapril
1H-Indole-2-carboxylic acid, 1-[2-[(1-
87679-71-8
DE
3151690
Antihypertensive, renin 
Hypertension, 



carboxy-3-phenylpropyl)amino]-1-
87679-37-6 


system
general



oxopropyl]octahydro-, [2S-
52-53-9







[1[R*(R*)],2Alpha,3aAlpha,7aβ]]-[CAS]







tranexamic acid
Cyclohexanecarboxylic acid, 4-
1197-18-8
U.S.
3,950,405
Antifibrinolytic
Menstrual disorder, 



(aminomethyl)-, trans-[CAS]




general


tranilast
Benzoic acid, 2-[[3-(3,4-
53902-12-8
U.S.
3,940,422
Vulnerary
Wound healing



dimethoxyphenyl)-1-oxo-2-








propenyl]amino]-[CAS]







trans-retinoic 
Retinoic acid[CAS]
302-79-4


Anticancer, other
Cancer, general


acid








Tranyl-

155-09-9






cypromine








trapidil
[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine,
15421-84-8
DD
55956
Vasodilator, coronary




N,N-diethyl-5-methyl-[CAS]







Trastuzumab

180288-69-1






travoprost
5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-
157283-68-6


Formulation, mucosal, 
Glaucoma



hydroxy-4-(3-(trifluoromethyl)phenoxy)-



topical




1-butenyl)cyclopentyl)-, 1-








methylethylester








(1R(1Alpha(Z),2B(1E,3R*),3Alpha,








5Alpha) [CAS]
.






Traxanox

58712-69-9






traxoprodil
1-Piperidineethanol, 4-hydroxy-Alpha-
134234-12-1


Analgesic, other
Pain, general



(4-hydroxyphenyl)-β-methyl-4-phenyl-,
188591-67-5







(AlphaS,βS)-[CAS]







trazodone
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one,
19794-93-5
U.S.
4,215,104
Antidepressant




2-[3-[4-(3-chlorophenyl)-1-
25332-39-2







piperazinylipropyl]-[CAS]







Tremacamra

155576-45-7






Trenbolone

10161-33-8






Trengestone

5192-84-7






treosulfan
1,2,3,4-Butanetetrol, 1,4-
299-75-2
WO
8401506
Anticancer, alkylating




dimethanesutfonate, [S-(R*,R*)]-[CAS]







trepibutone
Benzenebutanoic acid, 2,4,5-triethoxy-
41826-92-0
GB
1387733
Antispasmodic




Gamma-oxo-[CAS]







treprostinol
Prosta-5,13-dien-1-oic acid, 6,9-epoxy-
35121-78-9
U.S.
6,054,486
Formulation, 
Hypertension, 



11,15-dihydroxy-,
61849-14-7


parenteral, other
pulmonary



[5Z,9Alpha, 11Alpha, 13E, 15S]-[CAS]







tretinoin
Retinoic acid [CAS]
302-79-4


Formulation, dermal, 
Acne







topical



tretoquinol
6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-
18559-59-6
ZA
6802416
Antiasthma




1-[(3,4,5-trimethoxyphenyl)methyl]-, (S)
30418-38-3







[CAS]
21650-42-0






TRH

24305-27-9






TRI-50b
TRI 50b [CAS]
226214-49-9


Antithrombotic
Thrombosis, 








general


Triacetin

102-76-1






Triamcinolone 

76-25-5






Acetonide








Triamcinolone 

31002-79-6






Benetonide








Triamcinolone 

5611-51-8






Hexacetonide








triamcinolone
Pregna-1,4-diene-3,20-dione, 9-fluoro-
76-25-5


Formulation, inhalable, 
Asthma



11,21-dihydroxy-16,17-[(1-
124-94-7


topical




methylethylidene)bis(oxy)]-,








(11β, 16Alpha)-[CAS]







Triamterene

396-01-0






triapine
Triapine [CAS]
236392-56-6
U.S.
6,458,816
Anticancer, 
Cancer, leukaemia, 







antimetabolite
general


Triaziquone

68-76-8






triazolam
8-chloro-6-(2-chlorophenyl)-1-methyl-
28911-01-5
U.S.
3,980,790
Hypnotic/Sedative
Insomnia



4H-[1,2,4]-triazolo[4,3-








a][1,4]benzodiazepine







Tribenoside

10310-32-4






Trichlorfon

52-68-6






Trichlormethiazide

133-67-5






Trichlormethine

555-77-1






Trichloroethylene

79-01-6






Triclobisonium

79-90-3






Triclocarban

101-20-2






Triclofenol 

5714-82-9






Piperazine








Triclofos

306-52-5






Triclosan

3380-34-5






Tricromyl

85-90-5






Tridihexethyl 

125-99-5






Iodide








trientine
1,2-Ethanediamine, N,N2-
38260-01-4 


Metabolic and 
Wilson's disease



bis(2aminoethyl)-, [CAS]
112-24-3


enzyme



Triethanolamine

102-71-6






Triethylene-

51-18-3






melamine








Triethylene-

545-55-1






phosphoramide








Tnethylenethio-

52-24-4






phosphoramide








Trifluoperazine

117-89-5 






Trifluperidol

749-13-3






Triflupromazine

146-54-3






trifluridine
Thymidine, Alpha,Alpha,Alpha-trifluoro-
70-00-8
U.S.
3,201,387
Antiviral, other
Infection, herpes



[CAS]




virus, general


triflusal
Benzoic acid, 2-(acetyloxy)-4-
322-79-2
U.S.
4,096,252
Antithrombotic
Thrombosis,



(trifluoromethyl)-[CAS]




general


Trihexyphenidyl

52-49-3






trilostane
Androst-2-ene-2-carbonitrile, 4,5-epoxy-
13647-35-3
U.S.
3,296,255
Anticancer, hormonal
Cancer, breast



3,1 7-dihydroxy-, (4Alpha,5Alpha, 17β)-








[CAS]







Trimazosin

35795-16-5






trimebutine
Benzoic acid, 3,4,5-trimethoxy-, 2-
34140-59-5
DE
2151716
Antispasmodic




(dimethylamino)-2-phenylbutyl ester,
39133-31-8







(Z)-2-butenedioate (1:1) [CAS]







Trimecaine

616-68-2






Trimeprazine

84-96-8






Trimetazidine

5011-34-7






Trimethadione

127-48-0






Trimethaphan

68-91-7






Trimetho-

138-56-7






benzamide








Trimethoprim

738-70-5






Trimetozine

635-41-6






trimetrexate
2,4-Quinazolinediamine, 5-methyl-6-
52128-35-5
U.S.
4,391,809
Antifungal
Infection,



[[(3,4,5-
82952-64-5



Pneumocystis



trimethoxyphenyl)amino]methyl]-[CAS]




jiroveci


trimipramine
5H-Dibenz[b,f]azepine-5-propanamine,
521-78-8


Antidepressant




10,11-dihydro-N,N,t1-trimethyl-, (Z)-2-
739-71-9







butenedioate (1:1) [CAS]







Trimoprostil

69900-72-7 






Trioxsalen

3902-71-4






tripamide
Benzamide, 3-(aminosulfonyl)-4-chloro-
73803-48-2
JP
7305585
Antihypertensive,
Hypertension,



N-(octahydro-4,7-methano-2H-isoindol-



diuretic
general



2-yl-,








(3aAlpha,4Alpha,7Alpha,7aAlpha)-








[CAS]







Triparanol

78-41-1






Tripelennamine

91-81-6






Triprolidine

486-12-4






triptorelin
Luteinizing hormone-releasing factor
124508-66-3
U.S.
4,010,125
Releasing hormones
Cancer, prostate



(pig), 6-D-tryptophan-[CAS]
57773-63-4






tritiozine
Morpholine, 4-[thioxo(3,4,5-
35619-65-9
U.S.
3,862,138
Antiulcer




trimethoxyphenyl)methyl]-[CAS]







Tritoqualine

14504-73-5






TRK-530
Phosphonic acid, [[[4-
151425-92-2
WO
9410181
Antiarthritic, other
Arthritis, 



(methylthio)phenyl]thio]methylene]bis-,




rheumatoid



disodium salt [CAS]







TRK-820
2-Propenamide, N-[(5Alpha,6β)-17-
152658-17-8
WO
9315081
Antipruritic/inflamm, 
Pruritus



(cyclopropylmethyl)-4,5-epoxy-3,14-



non-allergic




dihydroxymorphinan-6-yl]-3-(3-furanyl)-








N-methyl-, monohydrochloride, (2E)-








[CAS]







Troclosene

2244-21-5






trofosfamide
3-2-(chloroethyl)-2-[bis(2-
22089-22-1
GB
1188159
Anticancer, alkylating




chloroethyl)amino]tetrahydro-2H-1,3,2-








oxazaphosphonn 2-oxide







Troglitazone

97322-87-7






Troleandomycin

2751-9-9






Trolnitrate

588-42-1






tromantadine
N-(1-adamantyl)-2-(2-dimethylamine
53783-83-8
DE
1941218
Antiviral, other
Infection, herpes 



ethoxy)acetamide




simplex virus


Tromethamine

77-86-1






Tropacine

6878-98-4






Tropesin

65189-78-8






Tropicamide

1508-75-4






tropine
1H-Indole-3-acetic acid, 1-(4-
65189-78-8


Antiarthritic, other




chlorobenzoyl)-5-methoxy-2-methyl-, 2-








carboxy-2-phenylethyl ester, (+/−)-








[CAS]







tropisetron
1H-Indole-3-carboxylic acid, 8-methyl-8
89565-68-4
GB
2125398
Antiemetic
Chemotherapy-



azabicyclo[3.2.1]oct-3-yl ester, endo-




induced nausea 



[CAS]




and vomiting


Trospectomycin

88669-04-9






trospium
3Alpha-Hydroxyspiro[1AlphaH,5AlphaH-
10405-02-4


Urological
Pollakisuria



nortropane-8,1′-pyrrolidinium]








benzilate







trovafloxacin
1,8-Naphthyridine-3-carboxylic acid, 7-
147059-72-1
U.S.
5,164,402
Quinolone 
Infection, respiratory 



(6-amino-3-azabicyclo[3.1.0]hex-3-yl)-1-
147059-75-4


antibacterial
tract, general



(2,4-difluorophenyl)-6-fluoro-1,4-








dihydro-4-oxo-,








(1Alpha,5Alpha,6Alpha)-, [CAS]







troxacitabine
2(1H)-Pyrimidinone, 4-amino-1-(2-
145918-75-8


Anticancer, other
Cancer, leukaemia, 



(hydroxymethyl)-1,3-dioxolan-4-yl)-,




acute myelogenous



(2S-cis)-[CAS]







Troxerutin

7085-55-4






troxipide
Benzamide, 3,4,5-trimethoxy-N-3-
30751-05-4
U.S.
3,647,805
Antiulcer
Ulcer, gastric



piperidinyl-, (+/−)-[CAS]
99777-81-8






Trypan Red

574-64-1






Tryparsamide

554-72-3






Tryptophan

73-22-3






TSH

9002-71-5






TSN-09
6,14-Ethenomorphinan-7-methanol, 17-
52485-79-7


Formulation, 
Pain, cancer



(cyclopropylmethyl)-Alpha-(1,1-



transdermal, patch




dimethylethyl)-,5-epoxy-18,19-dihydro-








3-hydroxy-6-methoxy-Alpha-methyl-,








[5Alpha,7Alpha,(S)]-[CAS]







TU-2100
Nonanedioic acid, bis[(2-

U.S.
6,180,669
Antiacne
Acne



(ethoxycarbonyl)phenyl] ester







Tuaminoheptane

123-82-0






Tubercidin

69-33-0






Tubocurarine 

57-94-3






Chloride








tulobuterol
Benzenemethanol, 2-chloro-Alpha-
41570-61-0
DE
2244737
Antiasthma
Asthma



[[(1,1-dimethylethyl)amino]methyl]-








[CAS]







TV-3326
N-(Propargyl-(3R)aminoindan-5-yl)-



Cognition enhancer
Alzheimer's 



ethyl methyl carbamate




disease


TY-11223
Acetic acid, [2-[2,3,3a,6,7,7a-
140694-43-5
U.S.
4,837,342
Antithrombotic
Unspecified



hexahydro-2-hydroxy-1-(3-hydroxy-4,4-








dimethyl-1,6-nonadiynyl)-1H-inden-5-








yl]ethoxy]-, [1S-








[1Alpha(R*),2β,3aAlpha,7aAlpha]]-








[CAS]







TY-12533
6,7,8,9-Tetrahydro-2-methyl-5H-

U.S.
6,258,829
Antiarrhythmic
Unspecified



cyclohepta[b]pyridine-3-








carbonylguanidine maleate







TYB-3215
D-Glucitol, 1,4:3,6-dianhydro-, dinitrate
87-33-2


Formulation, modified-
Angina, general



[CAS]



release, other



Tybamate

4268-36-4






tyloxapol
4-(1,1,3,3-Tetramethylbutyl)phenol
25301-02-4


Formulation, inhalable, 




polymer with formaldehyde and oxirane



topical




[CAS]







Tymazoline

24243-97-8 






Tyramine

51-67-2






Tyropanoate

7246-21-1






Ubenimex

58970-76-6






ufenamate
Benzoic acid, 2-[[3-
67330-25-0
BE
861852
Antipruritic/inflamm, 




(trifluoromethyl)phenyl]amino]-, butyl



non-allergic




ester [CAS]







Undecylenic 

112-38-9






Acid








Unoprostone

120373-36-6






UR-8880
4-[4-Chloro-5-(3-fluoro-4-



Anti-inflammatory
Inflammation, 



methoxyphenyl)imidazol-1-imidazol-1-




general



yl]benzenesulfonamide-[CAS]







Uracil Mustard

66-75-1






Uralyt-U
1,2,3-Propanetricarboxylic acid, 2-
55049-48-4
U.S.
4,400,535
Urological




hydroxy-, potassium sodium salt








(5:6:6), hydrate [CAS]







urapidil
2,4(1H,3H)-Pyrimidinedione, 6-[[3-[4-(2
34661-75-1
GB
1309324
Antihypertensive, 
Hypertension, general



methoxyphenyl)-1-



adrenergic




piperazinyl]propyl]amino]-1,3-dimethyl-








[CAS]







urea
Urea [CAS]
57-13-6


Antipsoriasis



Uredepa

302-49-8






Urethan

51-79-6






Uridine 5¢-

63-39-8






Triphosphate








Urinastatin

80449-31-6 






ursodeoxy-
3Alpha,7β-dihydroxy-5β-cholan-24-oic
128-13-2


Formulation, other, 
Cirrhosis, primary 


cholic acid
acid [CAS]



Cirrhosis
biliary







primary biliary, 








hepatic dysfunction








biliary calcalus



Ursodiol

128-13-2






Ushercell


U.S.
6,063,773
Formulation, mucosal, 
Contraceptive, 







topical
female


Uzarin

20231-81-6 






valaciclovir
L-Valine, 2-[(2-amino-1,6-dihydro-6-
124832-26-4
EP
308065
Antiviral, other
Infection, herpes 



oxo-9H-purin-9-yl)methoxy]ethyl ester




simplex virus



[CAS]







Valacyclovir

124832-26-4






valdecoxib
Benzenesulfonamide, 4-(5-methyl-3-
181695-72-7
U.S.
5859257
Antiarthritic, other
Arthritis, 



phenyl-4-isoxazolyl)-[CAS]




rheumatoid


Valdetamide

512-48-1






Valethamate

90-22-2






valganciclovir
L-Valine, 2-((2-amino-1,6-dihydro-6-
175865-59-5
EP
694547
Antiviral, other
Infection, 



oxo-9H-purin-9-yl)methoxy)-3-
175865-60-8



cytomegalovirus



hydroxypropyl ester [CAS]







Valnoctamide
4171-13-5







valomaciclovir
L-Valine (3R)-3-((2-amino-1,6-dihydro-
1951 56-77-5


Antiviral, other
Infection, herpes 



6-oxo-9H-purin-9-yl)methyl)-4-((1-




simplex virus



oxooctadecyl)oxy)butyl ester [CAS]







valproate
Pentanoic acid, 2-propyl-, [CAS]
76584-70-8
U.S.
4,988,731
Antiepileptic
Epilepsy, 




1069-66-5



generalized, tonic-








clonic


Vaiproic Acid

99-66-1






Valpromide

2430-27-5






valrocemide
Pentanamide, N-(2-amino-2-oxoethyl)-
92262-58-3
U.S.
5,585,358
Antiepileptic
Epilepsy, general



2-propyl-[CAS]







valrubicin
Pentanoic acid, 2-(1,2,3,4,6,11-
56124-62-0
U.S.
4,035,566
Anticancer, antibiotic
Cancer, bladder



hexahydro-2,5,12-trihydroxy-7-methoxy








6,11-dioxo-4-((2,3,6-trideoxy-3-








((trifluoroacetyl)amino)-Alpha-L-lyxo-








hexopyranosyl)oxy)-2-naphthacenyl)-2-








oxoethyl ester (2S-cis)-[CAS]







valsartan
L-Valine, N-(1-oxopentyl)-N-[[2′-(1H-
137862-53-4
EP
443983
Antihypertensive, renin 
Hypertension, 



tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-



system
general



[CAS]







Valspodar

121584-18-7






vardenafil
Piperazine, 1-(3-(1,4-dihydro-5-methyl(-
224785-90-4


Male sexual 
Sexual dysfunction, 



4-oxo-7-propylimidazo(5,1-f)(1,2,4)-



dysfunction
male, general



triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-








ethyl-[CAS]







varespladib
Acetic acid, ((3-(aminooxoacetyl)-2-
172732-68-2
EP
675110
Septic shock treatment
Sepsis



ethyl-1-(phenylmethyl)-1H-indol-4-
172733-42-5







yl)oxy)-[CAS]







Varicella 








Virus Vaccine








vatanidipine
3,5-Pyridinedicarboxylic acid, 1,4-
116308-55-5
EP
257616
Neuroprotective
Hypertension, 



dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,
133743-71-2



general



2-[4-[4-(diphenylmethyl)-1-








piperazinyllphenyl]ethyl methyl ester,








[CAS]







VEA


U.S.
6,007,817
Radio/
Cancer, general







chemosensitizer



vecuronium
Piperidinium, 1-
50700-72-6
U.S.
4,237,126
Muscle relaxant
Anaesthesia, 



bis(acetyloxy)-2-(1-




adjunct



piperidinyl)androstan-1 6-yl]-1-methyl-,








[CAS]







Velnacrine

104675-29-8






venlafaxine
Gyclohexanol, 1-[2-(dimethylamino)-1-
93413-69-5
GB
2227743
Antidepressant
Depression, general



(4-methoxyphenyl)ethyl]-, [CAS]
99300-78-4






Veralip ride

66644-81-3






verapamil
Benzeneacetonitrile, Alpha-[3-[[2-(3,4-
52-53-9


Formulation, modified-
Hypertension, general



dimethoxyphenyl)ethyl]methylamino]



release, other




propyl]-3,4-dimethoxy-Alpha-(1-








methylethyl)-[CAS]







verteporfin
23H,25H-Benzo[b]porphine-9,13-
129497-78-5
U.S.
5,238,940
Ophthalmological
Macular 



dipropanoic acid, 18-ethenyl-4,4a-




degeneration



dihydro-3,4-bis(methoxycarbonyl)-








4a,8,14,19-tetramethyl-, monomethyl








ester, trans-[CAS]







vesnarinone
Piperazine, 1-(3,4-dimethoxybenzoyl)-4-
81840-15-5
GB
2086896
Cardiostimulant
Heart failure



(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)-








[CAS]







Vetrabutine

3735-45-3






VF-233
Benzene carboximidamide, N,3,4,5-
95933-74-7
U.S.
4,623,659
Cardiovascular
Reperfusion injury



tetrahydroxy-[CAS]







VI-0134


U.S.
6,403,597
Male sexual 
Premature 







dysfunction
ejaculation


vidarabine
9H-Purin-6-amine, 9-β-D-
24356-66-9
GB
1159290
Antiviral, other
Infection, herpes 



arabinofuranosyl-[CAS]
5536-17-4



virus, general


vigabatrin
5-Hexenoic acid, 4-amino-[CAS]
68506-86-5
GB
1472525
Antiepileptic
Epilepsy, partial 




60643-86-9



(focal, local)


vilazodone
2-Benzofurancarboxamide, 5-[4-[4-(5-
163521-12-8
EP
648767
Antidepressant
Depression, 



cyano-1H-indol-3-yl)butyl]-1-




general



piperazinyl]-[CAS]







Viloxazine

46817-91-8






Viminol

21363-18-8






Vinbarbital

125-44-0






Vinblastine

865-21-4






vinburnine
Eburnamenin-14(15H)-one,
474-00-0
DE
1932245
Cognition enhancer




(3Alpha,16Alpha)-[CAS]
4880-88-0






Vincamine

1617-90-9






Vinconate

70704-03-9






vincristine
Vincaleukoblastine, 22-oxo-, sulfate
2068-78-2
EP
207831
Formulation, 
Cancer, general



(1:1) (salt) [CAS]
57-22-7


parenteral, other



vindesine
Vincaleukoblastine, 3-(aminocarbonyl)-
53643-48-4
GB
1463575
Anticancer, other
Cancer, leukaemia, 



O4-deacetyl-3-de(methoxycarbonyl)-
59917-39-4



acute lymphocytic



[CAS]







vinflunine
Aspidospermidine-3-carboxylic acid, 4-
162652-95-1
FR
2707988
Anticancer, other
Cancer, general



(acetyloxy)-6,7-didehydro-15-








[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-








1,3,4,5,6,7,8,9-octahydro-8-








(methoxycarbonyl)-2,6-methano-2H-








azecino[4,3-b]indol-8-yl]-3-hydroxy-16-








methoxy-1-methyl-, methyl ester,








(2β,3β,4β,5Alpha,12β,19Alpha)-








[CAS]







vinorelbine
C′-Norvincaleukoblastine, 3,4′-
71486-22-1
EP
10458
Anticancer, other
Cancer, lung, 



didehydro-4′-deoxy-[CAS]




non-small cell


vinpocetine
Ebumamenine-14-carboxylic acid, ethyl
42971-09-5
GB
1405127
Cognition enhancer
Cognitive disorder, 



ester, (3Alpha,l6Alpha)-[CAS]




general


Vinyl Ether

109-93-3






Vinylbital

2430-49-1






Viquidil

84-55-9






Viridin

3306-52-3






Visnadine

477-32-7






Vitamin A

68-26-8






vitamin B12
Vitamin B12 [CAS]
68-19-9


Formulation, 
Anaemia, general







transmucosal, nasal



vitamin C
L-Ascorbic acid [CAS]
50-81-7


Formulation, modified-
Nutrition







release, <=24 hr



Vitamin D2

50-14-6






Vitamin D3

67-97-0






Vitamin KS

83-70-5






Vitamins, 








Prenatal








VLA-4 
((R,S)-4-(4-(Amino-imino-methyl)-

EP
842943
Antiasthma
Asthma


antagonists
phenyl)-3-((4-biphenylyl)-methyl)-4-








methyl-2,5-dioxoimidazolidin-1-yl)-








acetyl-L-N-methyl-aspartyl-L-








phenylglycine







VNP-40101M
1,2-Bis(methylsulfonyl)-1-(2-

U.S.
6,040,338
Anticancer, alkylating
Cancer, general



chloroethyl)-2-








(methylamino)carbonylhydrazine







voglibose
D-epi-Inositol, 3,4-dideoxy-4-[[2-
83480-29-9
EP 
56194
Antidiabetic
Diabetic, Type II



hydroxy-1-(hydroxymethyl)ethyl]amino]-








2-C-(hydroxymethyl)-[CAS]







vonconazole
4-Pyrimidineethanol, Alpha-(2,4-
137234-62-9
EP
440372
Antifungal
Infection, fungal, 



difluorophenyl)-5-fluoro-β-methyl-Alpha-




general



(1H-1,2,4-triazol-1-ylmethyl)-, (R-








(R*,S*))-[CAS]







Vorozole

129731-10-8






VUF-K-8788
7-[3-[4-(2-Quinolinylmethyl)-1-



Antiasthma
Asthma



piperazinyl]propoxy]-3,4-dihydro-2H-1,4-








benzothiazine-3-one







Warfarin

81-81-2






WF-10
Tetrachlorodecaoxide [CAS]
92047-76-2


Radio/chemoprotective
Chemotherapy-








induced injury, 








bone marrow, general


WMC-79
2-(3-[4-[3-(6-oxo-6H-2,10b-diaza-



Anticancer, other
Cancer, colorectal



aceanthrenylen-5-ylamino)propyl]-








piperazin-1-yl]propyl)-5-nitro-2-aza-








phenalene-1,3-dione







wound healing 


U.S.
5,897,880
Formulation, 
Ulcer, diabetic


matrix




transdermal, patch



WP-170


U.S.
6,531,121
Cytokine
Unspecified


xaliproden
Pyridine, 1,2,3,6-tetrahydro-1-[2-(2-
135354-020-8
EP
101381
Neuroprotective
Amyotrophic 



naphthalenyl)ethyl]-4-(3-
90494-79-4



lateral sclerosis



(trifluoromethyl)phenyl]-, [CAS]







xamoterol
4-Morpholinecarboxamide, N-[2-[[2-
73210-73-8
GB
2002748
Cardiostimulant
Heart failure



hydroxy-3-(4-
81801-12-9







hydroxyphenoxy)propyl]amino]ethyl]-,








(+/−)-[CAS]







Xanomeline

131986-45-3






Xanthinol 

437-74-1






Niacinate








Xemilofiban

149820-74-6






Xenbucin

959-10-4






Xibenolol

81584-06-7






xibornol
Phenol, 4,5-dimethyl-2-(1.7,7-
13741-18-9
GB
1206774
Antibacterial, other
Infection, general



trimethylbicyclo[2.2.1]hept-2-yl)-, exo-








[CAS]







ximelagatran
Glycine, N-((R)-cyclohexyl-2-((2S)-2-
192939-46-1


Antithrombotic
Thrombosis, venous



((((4-








(hydroxyamino)iminomethyl)phenyl)








methyl)amino)carbonyl)-1-azetidinyl)2-








oxoethyl ethyl ester [CAS]







Ximoprofen

56187-89-4






xipamide
Benzamide, 5-(aminosulfonyl)-4-chloro-
14293-44-8
U.S.
3,567,777
Antihypertensive, 




N-(2,6-dimethylphenyl)-2-hydroxy-



diuretic




[CAS]







xorphanol
Morphinan-3-ol, 17-(cyclobutylmethyl)-
77287-89-9


Analgesic, other
Pain, cancer



8-methyl-6-methylene-, (8β)-[CAS]







XR-5118
2,5-Piperazinedione, 3-[[5-[[2-
174766-49-5
WO
9532190
Anticancer, other
Cancer, general



(dimethylamino)ethyl]thio]-2-








thienyl]methylene]-6-(phenylmethylene),








monohydrochlonde, (3Z,6Z)-[CAS]







XR-5944
N,N′-(1,2-Ethanediyl)bis(imino-2,1-

EP
934278
Anticancer, other
Cancer, general



ethanediyl)bis(9-methylphenazine-1-








carboxamide)







Xylometazoline

526-36-3






Xylose

58-86-6






YH-1885
2-Pyrimidinamine, 4-(3,4-dihydro-1-
178307-42-1
WO
9605177
Antiulcer
Ulcer, GI, general



methyl-2(1H)-isoquinolinyl)-N-(4-








fluorophenyl)-5,6-dimethyl-,








monohydrochloride [CAS]







YM-511
Benzonitrile, 4-[[(4-
148869-05-0
WO
9305027
Anticancer, hormonal
Cancer, breast



bromophenyl)methyl]-4H-1,2,4-triazol-4-








ylamino]-[CAS]







YM-598
potassium(E)-N-[6-methoxy-5-(2-



Anticancer, other
Cancer, prostate



methoxyphenoxy)-2-(pyrimidin-2-








yl)pyrimidin-4-yl]-2-








phenylethenesulfonamidate







Yahimbine

146-48-5






YT-146
Adenosine, 2-(1-octynyl)-[CAS]
90596-75-1 
U.S.
5,270,304
Anti-inflammation, 








general



Z-321
Thiazolidine, 3-((2,3-dihydro-1H-inden-
130849-58-0
EP
372484
Cognition enhancer
Dementia, senile, 



2-yl)acetyl)-4-(1-pyrrolidinylcarbonyl)-,




general



(R)-[CAS]







Z-335
(1H-Indene-5-acetic acid, 2[[[(4-
146731-14-8
JP
92506077
Antithrombotic
Peripheral vascular 



chlorophenyl)sulfonyl]amino]methyl]-




disease



2,3-dihydro, monosodium salt) [CAS]







zafirtukast
Carbamic acid, [3-[[2-methoxy-4-[[[(2-
107753-78-6
EP
199543
Antiasthma
Asthma



methylphenyl)sulfonyl]amino]carbonyl]








phenyl]methyl]-1-methyl-1H-indol-5-yl]-,








cyclopentyl ester [CAS]







zalcitabine
Cytidine, 2′,3′-dideoxy-[CAS]
7481-89-2
U.S.
4,879,277
Antiviral, anti-HIV
Infection, HIV/AIDS


Zaldaride

109826-26-8






zaleplon
Acetamide, N-[3-(3-cyanopyrazolo[1,5-
151319-34-5
EP
776898
Hypnotic/Sedative
Insomnia



a]pynmidin-7-yl)phenyl]-N-ethyl-[CAS]







zaltoprofen
Dibenzo[b,f]thiepin-2-acetic acid, 10,11-
74711-43-6
JP
55053282
Anti-inflammatory




dihydro-Alpha-methyl-10-oxo-[CAS]







zanamivir
5-Acetamido-2,6-anhydro-3,4,5-
139110-80-8
WO
9116320
Antiviral, other
Infection, influenza 



trideoxy-4-guanidino-D-glycero-D-




virus



galacto-non-2-enonic acid [CAS]







zanapezil
1-Propanone, 3-(1-(phenylmethyl)-4-
142852-50-4
EP
487071
Cognition enhancer
Alzheimer's disease



piperidinyl)-1-(2,3,4,5-tetrahydro-1H-1-








benzazepin-8-yl)-[CAS]







Zatebradine

85175-67-3






ZD-0473
Platinum, amminedichloro(2-
181630-15-9
EP
727430
Anticancer, alkylating
Cancer, ovarian



methylpyridine)- (SP-4-3)-[CAS]







ZD-0947


WO
9528388
Urological
Overactive bladder


ZD-6126
N-acetylcolchinol-O-phosphate



Anticancer, other
Cancer, general


ZD-9331
1H-Tetrazole-5-butanoic acid, Alpha-
153537-73-6
GB
2264946
Anticancer, 
Cancer, pancreatic



((4-(((1,4-dihydro-2,7-dimethyl-4-oxo-6-



antimetabolite




quinazolinyl)methyl)-2-propynylamino)-








2-fluorobenzoyl)amino) (S)-[CAS]







zebularine
2(1H)-Pyrimidinone, 1-β-D-
3690-10-6


Anticancer, other
Cancer, general



ribofuranosyl-[CAS]







zelandopam
7,8-Isoquinolinediol, 4-(3,4-
138086-00-7
JP
03190818
Vasodilator, renal
Hypertension, 



dihydroxyphenyl)-1,2,3,4-tetrahydro-,




general



[CAS]







Zenarestat

112733-06-9






Ziconotide

107452-89-1






zidovudine
Thymidine, 3′-azido-3′-deoxy-[CAS]
30516-87-1
U.S.
4,724,232
Antiviral, anti-HIV
Infection, HIV/AIDS


zileuton
Urea, N-(1-benzo[b]thien-2-ylethyl)-N-
111406-87-2
EP
279263
Antiasthma
Asthma



hydroxy-[CAS]







Zimeldine

56775-88-3






zinc acetate
hexakis(\m-acetato)-\m4-oxotetrazinc
12129-82-7


Antiviral, other
Infection, herpes 







virus prophylaxis
simplex


zinc acexamate
Hexanoic acid, 6-(acetylamino)-, zinc
70020-71-2
EP
369088
Antiulcer
Ulcer, duodenal



salt (2:1)-[CAS]







zinc ibuprofenate

78416-80-5


Anti-inflammatory, 
Inflammation, 







topical
dermal


Zinc p-

127-82-2






Phenolsulfonate








Zinc Salicylate

16283-36-6






Zinostatin

9014-2-2






zinostatin 

123760-07-6
EP
136791
Anticancer, antibiotic
Cancer, liver


stimalamer








Zipeprol

34758-83-3






ziprasidone
2H-Indol-2-one, 5-(2-(4-(1,2-
122883-93-6
EP
281309
Neuroleptic
Schizophrenia



benzisothiazol-3-yl)-1-piperazinyl)ethyl)
146939-27-7







6-chloro-1,3-dihydro-[CAS]







zofenopril
L-Proline, 1-[3-(benzoylthio)-2-methyl-1-
75176-37-3
GB
2028327
Antihypertensive, renin 
Hypertension, general



oxopropyl]-4-(phenylthio)-,
81872-10-8


system




[1(R*),2Alpha,4Alpha]-[CAS]
81938-43-4






zofenopril + 
L-Proline, 1-[3-(benzoylthio)-2-methyl-1-



Formulation, fixed-dose
Hypertensions, general


HCTZ
oxopropyl]-4-(phenylthio)-,



combinations




[1(R*),2Alpha,4Alpha]- + 6-Chloro-3,4-








dihydro-2H-1,2,4-benzothiazide-7-








sulfonamide 1,1-dioxide [CAS]







zoledronic acid
Phosphonic acid, [1-hydroxy-2-(1H-
118072-93-8
EP
531253
Osteoporosis treatment
Hypercalcaemia of



imidazol-1-yl)ethylidene]bis-[CAS]
165800-06-6



malignancy


zolimidine
2-(p-methylsulfonylphenyl)imidazo[1,2-
1222-57-7
U.S.
3,318,880
Antiulcer
Gastritis



a]pyridine







zolmitriptan
2-Oxazolidinone, 4-((3-(2-
139264-17-8
WO
9118897 
Antimigraine
Migraine



(dimethylamino)ethyl)-1H-indol-5-








yl)methyl)-, (5)-[CAS]







zolpidem
Imidazo[1,2-a]pyridine-3-acetamide,
99294-93-6
EP
50563
Hypnotic/Sedative
Insomnia



N,N,6-trimethyl-2-(4-methylphenyl)-(R-
82626-48-0







(R*,R*))-2,3-dihydroxybutanediotade








(2:1) [CAS]







Zomepirac

33369-31-2






zonampanel
1(2H)-Quinoxalineacetic acid, 3,4-
210245-80-0


Neuroprotective
Ischaemia, cerebral



dihydro-7-(1H-imidazol-1-yl)-6-nitro-2,3








dioxo-[CAS]







zoniporide
1H-pyrazole-4-carboxamide,N-
249296-45-5


Cardiovascular
Unspecified



(aminoimino methyl)-5-cyclopropyl-1-(5-








quinolinyl)-,







zonisamide
1,2-Benzisoxazole-3-
68291-97-4
GB
2025931
Antiepileptic
Epilepsy, 



methanesulfonamide [CAS]
68291-98-5



generalized, tonic-








clonic


zopiclone
1-Piperazinecarboxylic acid, 4-methyl-,
43200-80-2
GB
1358680
Hypnotic/Sedative
Insomnia



6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-








oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester








[CAS]







Zopolrestat

110703-94-1






Zorubicin

54083-22-6 






zosuquidar
1-Piperazineethanol, 4-(1,1-difluoro-
167465-36-3


Radio/chemosensitizer
Cancer, Ieukaemia, 



1,1a,6,10b-




acute



tetrahydrodibenzo[a,e]cyclopropa[c]




myelogenous



cyclohepten-6-yl)-Alpha-[(5-








quinolinyloxy)methyl]-, [6(R)-








(1aAlpha,6Alpha,10bAlpha)]-[CAS]







zotepine
Ethanamine, 2-1(8-
26615-21-4
GB
1247067
Neuroleptic
Schizophrenia



chlorodibenzo[b,t]thiepin-10-yl)oxy]-








N,N-dimethyl-[CAS]







ZP-123


WO
0162775
Antiarrhythmic
Arrhythmia, general


Z-tamoxifen
Ethanamine, 2-[4-(1,2-diphenyl-1-
10540-29-1


Anticancer, hormonal
Cancer, colorectal



butenyl)phenoxy]-N,N-dimethyl-, (Z)-








[CAS]







zuclopenthixol
1-Piperazineethanol, 4-[3-(2-chloro-9H-
53772-83-1
EP
270282
Neuroleptic
Psychosis, general



thioxanthen-9-ylidene)propyl]-, (Z)-
982-24-1







[CAS]
85721-05-7








64053-00-5

## Claims

1. A propylene glycol solvate of a sodium salt of celecoxib having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol.

2. A propylene glycol solvate of celecoxib sodium trihydrate having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol: 3 hydrate.

3. A propylene glycol solvate of celecoxib selected from:
a) a propylene glycol solvate of celecoxib sodium trihydrate characterized by a thermogravimetric analysis of FIG. 18 or FIG. 20, said propylene glycol solvate of celecoxib sodium trihydrate having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol: 3 hydrate; or
b) a propylene glycol solvate of a sodium salt of celecoxib characterized by a thermogravimetric analysis of FIG. 1, said propylene glycol solvate of a sodium salt of celecoxib having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol.

4. The propylene glycol solvate of celecoxib according to claim 3, wherein the form is a propylene glycol solvate of celecoxib sodium trihydrate characterized by a thermogravimetric analysis of FIG. 18, said propylene glycol solvate of celecoxib sodium trihydrate having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol: 3 hydrate.

5. The propylene glycol solvate of celecoxib according to claim 3, wherein the form is a propylene glycol solvate of celecoxib sodium trihydrate characterized by a thermogravimetric analysis of FIG. 20, said propylene glycol solvate of celecoxib sodium trihydrate having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol: 3 hydrate.

6. The propylene glycol solvate of celecoxib according to claim 3, wherein the form is a propylene glycol solvate of a sodium salt of celecoxib characterized by a thermogravimetric analysis of FIG. 1, said propylene glycol solvate of a sodium salt of celecoxib having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol.

7. A propylene glycol solvate of celecoxib selected from:
a) a propylene glycol solvate of celecoxib sodium trihydrate characterized by the PXRD pattern of FIG. 19 or FIG. 21, said propylene glycol solvate of celecoxib sodium trihydrate having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol: 3 hydrate; or
b) a propylene glycol solvate of a sodium salt of celecoxib characterized by a PXRD pattern of FIG. 2A, 2B, 2C or 2D, said propylene glycol solvate of a sodium salt of celecoxib having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol.

8. The propylene glycol solvate according to claim 7, wherein said propylene glycol solvate is a propylene glycol solvate of celecoxib sodium trihydrate characterized by the PXRD pattern of FIG. 19 and having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol: 3 hydrate.

9. The propylene glycol solvate according to claim 7, wherein said propylene glycol solvate is a propylene glycol solvate of celecoxib sodium trihydrate characterized by the PXRD pattern of FIG. 21 and having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol: 3 hydrate.

10. The propylene glycol solvate according to claim 7, wherein said propylene glycol solvate is a propylene glycol solvate of a sodium salt of celecoxib, said propylene glycol solvate of a sodium salt of celecoxib characterized by a PXRD pattern of FIG. 2A, 2B, 2C or 2D and having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol.

11. The propylene glycol solvate according to claim 7, wherein said propylene glycol solvate is a propylene glycol solvate of a sodium salt of celecoxib and said composition is characterized by the PXRD pattern of FIG. 2A.

12. The propylene glycol solvate according to claim 7, wherein said propylene glycol solvate is a propylene glycol solvate of a sodium salt of celecoxib and said composition is characterized by the PXRD pattern of FIG. 2B.

13. The propylene glycol solvate according to claim 7, wherein said propylene glycol solvate is a propylene glycol solvate of a sodium salt of celecoxib and said composition is characterized by the PXRD pattern of FIG. 2C.

14. The propylene glycol solvate according to claim 7, wherein said propylene glycol solvate is a propylene glycol solvate of a sodium salt of celecoxib and said composition is characterized by the PXRD pattern of FIG. 2D.

15. A pharmaceutical composition comprising an excipient and a form of a propylene glycol solvate of celecoxib selected from:
a) a propylene glycol solvate of celecoxib sodium trihydrate characterized by the PXRD pattern of FIG. 19 or FIG. 21, said propylene glycol solvate of celecoxib sodium trihydrate having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol: 3 hydrate; or
b) a propylene glycol solvate of a sodium salt of celecoxib characterized by a PXRD pattern of FIG. 2A, 2B, 2C or 2D, said propylene glycol solvate of a sodium salt of celecoxib having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol.

16. The composition according to claim 15, wherein said form is a propylene glycol solvate of celecoxib sodium trihydrate characterized by the PXRD pattern of FIG. 19 or FIG. 21 and having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol: 3 hydrate.

17. The composition according to claim 15, wherein said form is a propylene glycol solvate of a sodium salt of celecoxib, said propylene glycol solvate of a sodium salt of celecoxib characterized by a PXRD pattern of FIG. 2A, 2B, 2C or 2D and having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol.

18. The composition according to claim 17, wherein said form is a propylene glycol solvate of a sodium salt of celecoxib and said composition is characterized by the PXRD pattern of FIG. 2A.

19. The composition according to claim 17, wherein said form is a propylene glycol solvate of a sodium salt of celecoxib and said composition is characterized by the PXRD pattern of FIG. 2B.

20. The composition according to claim 17, wherein said form is a propylene glycol solvate of a sodium salt of celecoxib and said composition is characterized by the PXRD pattern of FIG. 2C.

21. The composition according to claim 16, wherein said form is a propylene glycol solvate of celecoxib sodium trihydrate characterized by the PXRD pattern of FIG. 19 and having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol: 3 hydrate.

22. The composition according to claim 16, wherein said form is a propylene glycol solvate of celecoxib sodium trihydrate characterized by the PXRD pattern of FIG. 21 and having a stoichiometric ratio of 1 celecoxib: 1 sodium: 1 propylene glycol: 3 hydrate.

23. The composition according to claim 17, wherein said form is a propylene glycol solvate of a sodium salt of celecoxib and said composition is characterized by the PXRD pattern of FIG. 2D.