#### FDA/Center for Food Safety and Applied NutritionUSDA/Food Safety and Inspection ServiceCenters for Disease Control and Prevention September 2003

## Quantitative Assessment of Relative Risk to Public Healthfrom Foodborne *Listeria monocytogenes*Among Selected Categories of Ready-to-Eat Foods

# Table of Contents

- Interpretive Summary  ( also available in PDF, 371 KB )  
- Table of Contents (including  List of Tables and List of Figures ) (also available in PDF )
- Summary of Public Comments and FDA/FSIS Revisions, Contributors, and Acknowledgements  (also available in PDF )
- Executive Summary  (also available in PDF, 272 KB )
- Abbreviations, Acronyms, and Glossary  (also available in PDF )
- I. Introduction  (also available in PDF )
- II. Hazard Identification  (also available in PDF )   - Listeriosis
  - Invasive Listeriosis
  - High Risk Individuals
  - Non-Invasive Listeriosis (Listerial Gastroenteritis)
  - Asymptomatic Carriage
  - Epidemiological Patterns of Listeriosis: Sporadic versus Outbreak-Associated Cases
  - Sporadic Listeriosis
  - Outbreak-Associated Listeriosis
- III.Exposure Assessment  (also available in PDF, 293 KB )   - Food Category Identification
  - Food Consumption Data
  - Food Contamination Data
  - Growth Data
  - Modeling: Listeria monocytogenes Levels in Food at Retail
  - Results: Modeled Contamination at Retail
  - Modeling: Growth Between Retail and Consumption
  - Modeling: Interaction of Storage Times and Temperatures
  - Modeling: Thermal Inactivation
  - Results: Modeled Listeria monocytogenes Levels in Food at Consumption
- IV.Hazard Characterization  (also available in PDF, 219 KB )    - Dose-Response Modeling
  - Comparison of the FDA/FSIS Revised Dose-Response Model to Other Dose-Response Models for *Listeria monocytogenes*
  - Dose-Response in Animal Surrogates
  - Data Collected from Animal Studies
  - Modeling: Dose-Response in Mice
  - Dose-Response Curves for Infection and Serious Illness
  - Variability in Virulence
  - Host Susceptibility
  - Modeling: Host Susceptibility
  - Dose-Response Scaling Factor
  - Results: Dose-Response Curves for Three Population Groups
- V.Risk Characterization  (also available in PDF, 514 KB )   - Simulation Modeling
  - Results
  - Overview and Discussion of Food Categories
  - Summaries of the Food Categories
- VI.'What If' Scenarios  (also available in PDF )
- VII.Interpretation and Conclusions  (also available in PDF )
- References  (also available in PDF )
- Apendices   - Appendices 1-4 (also available in PDF, 260 KB )     - Appendix 1: Chronology of Technical and Scientific Reviews of the Revised FDA/FSIS *Listeria Monocytogenes* Risk Assessment Document
    - Appendix 2: Summary of Public Comments and FDA/FSIS's Responses
    - Appendix 3: An Overview of the Risk Assessment
    - Appendix 4: The Foodborne Diseases Active Surveillance Network
  - Appendix 5: Food Categories Modeled Distributions and Related Information  (also available in PDF, 315 KB )
  - Appendix 6: Software  (also available in PDF )
  - Appendix 7: *Listeria* Contamination of Food Category Data Sets  (also available in PDF, 1,234 KB )
  - Appendix 8: Growth of *Listeria Monocytogenes* in Foods  (also available in PDF )
  - Appendix 9: Using Outbreak Investigations in Quantitative Risk Assessment  (also available in PDF )
  - Appendix 10: Additional Risk Characterization Information  (also available in PDF )
  - Appendix 11: Research Needs  (also available in PDF )
  - Appendix 12: Cluster Analysis for Grouping of Food Categories  (also available in PDF )

----

National Food Safety Programs

----

CFSAN Home
FSIS Home
CDC Home
Search/Subject Index
Disclaimers & Privacy Policy