<PAGE>

                                                                    Exhibit 10.1

                                  AMENDMENT TO
                 COMPUTER AND DATA PROCESSING SERVICES AGREEMENT

         This Amendment, effective March 1, 2004, amends the Computer and Data
Processing Services Agreement dated May 11, 1999, by and between Columbia
Information Systems, Inc. and LifePoint Hospitals, Inc., a Delaware corporation
("Customer").

                                   WITNESSETH:

         WHEREAS, HCA-Information Technology & Services, Inc. ("IT&S"), a
Tennessee corporation, is the successor-in-interest to Columbia Information
Systems, Inc.; and

         WHEREAS, IT&S and Customer entered into the Agreement, under which IT&S
provides specified computer and data processing services to Customer Facilities;
and

         WHEREAS, IT&S and Customer now desire to amend the Agreement to extend
its term.

         NOW, THEREFORE, pursuant to Section 14 of the Agreement and in
consideration of the premises, the mutual covenants and obligations set forth
herein, and good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, IT&S and Customer agree as follows:

1.       All references in the Agreement to "Columbia Information Systems, Inc."
are replaced with "HCA - Information Technology & Services, Inc." and all
references to "CIS" are replaced with "IT&S".

2.       The definition of "Initial Term" in Section 1(k) is deleted. A new
definition for "Term" is added as follows: "Term means the period beginning on
the effective date of this Agreement as set forth above and ending on December
31, 2009." All references in the Agreement to "Initial Term" are replaced with
"Term".

3.       All references in the Agreement to "Koala" are replaced with "Atlas".

4.       The term of the Agreement is extended through and including December
31, 2009.

5.       Section 1(e) of the Agreement shall be amended by replacing the phrase
"The Medical component" with the phrase "All Items".

6.       Section 1(i) of the Agreement shall be amended by deleting the phrase
"and listed in Exhibit A hereto."

<PAGE>

7.       Section 1(l) of the Agreement shall be amended by replacing "Koala
System" with "ATLAS System."

8.       Section 1(o) of the Agreement shall be amended by replacing "Exhibit B"
with "Exhibit A."

9.       Section 1(r) of the Agreement shall be amended by replacing "Exhibit B"
with "Exhibit A."

10.      Section 2(h)(2) of the Agreement shall be amended by replacing the last
sentence with the following:

         In the event that, during the term of this Agreement, Customer acquires
         from a third party, or constructs, a hospital or health care provider
         establishment, such an establishment shall become a Facility and shall
         begin implementation of the System within twelve (12) months of the
         closing of an acquisition transaction or the first date of operation of
         a newly-constructed Facility. Any such new Facility shall be entitled
         to a discount of fifty percent (50%) on Monthly Processing Fees for
         Clinical Systems and Patient Accounting for the first six (6) full
         calendar months after go-live and a discount of twenty-five percent
         (25%) on Monthly Processing Fees for Clinical Systems and Patient
         Accounting for full calendar months seven through twelve after go-live.
         If the go-live occurs other than on the first day of the month, the
         Monthly Processing Fees will be prorated over the number of days
         remaining in the month and the discounts will be applied beginning with
         the first full calendar month after go-live (For example, a Facility
         with a go-live date of May 15 will be charged a prorated license fee
         for May 15-31, without a discount, and then have the fifty percent
         discount referenced above applied in June through November with the
         twenty-five percent discount applied in December through May). The
         parties acknowledge that the following four (4) Facilities shall be
         entitled to the discounts set forth in the preceding sentence: Ville
         Platte Medical Center, Ville Platt, Louisiana; Lander Valley Medical
         Center, Lander, Wyoming; Logan Regional Medical Center, Logan, West
         Virginia; and Spring View Hospital, Lebanon, Kentucky.

11.      Section 3(d) of the Agreement shall be replaced with the following:

         IT&S may, in its sole discretion, migrate to a new System(s) which
         shall be offered to Customer by IT&S at a price to be determined at the
         end of the Customer Account Management implementation pilot by IT&S. If
         the Customer elects not to purchase such System(s), IT&S shall continue
         to support the current system utilized by Customer at prices to be
         determined by IT&S. The Customer shall make such

<PAGE>

         election within sixty (60) days after IT&S provides the pricing as set
         forth above. If Customer elects to continue use of the current system
         utilized by Customer, Customer shall begin paying the specified pricing
         on the date the last IT&S customer which is wholly-owned by HCA, Inc.
         (or one of its subsidiary companies) converts to such new System(s).

12.      Section 6(g) of the Agreement shall be amended by replacing the first
sentence with the following:

         IT&S agrees to make its Wide Area Network available to Customer for
         access and use by Facilities.

13.      The last sentence in Section 10(a) of the Agreement shall be replaced
with the following:

         FURTHERMORE, EACH PARTY'S LIABILITY TO THE OTHER FOR ANY OTHER DAMAGES
         CAUSED BY OR RESULTING FROM THE PERFORMANCE OR BREACH OF THIS
         AGREEMENT, WHETHER IN TORT, CONTRACT OR OTHERWISE, SHALL BE LIMITED IN
         EACH CASE TO $100,000 PER FACILITY AND $250,000 IN THE AGGREGATE, WHICH
         SUMS SHALL BE APPLIED AS A CREDIT AGAINST FEES.

14.      Section 11(d) of the Agreement shall be amended by adding the
following:

         In the event IT&S gives notice of its intention not to renew, the
         Wind-Down Period shall be two (2) years from the date IT&S provides
         notice of its intention not to renew. In the event that either party
         gives notice of its intention not to renew, Customer shall have the
         right to immediately begin an orderly de-installation of the Services
         and the Systems and shall receive a concomitant reduction in fees as
         set forth herein; provided, however, that such a de-installation shall
         not otherwise relieve Customer of its obligations stated elsewhere in
         this Agreement.

15.      Section 12(f) of the Agreement shall be amended by replacing "Client
Services" to "Customer Account Management."


16.      Exhibit A shall be replaced with the attached Exhibit A.

<PAGE>

17.      Exhibit B shall be replaced with the attached Exhibit B.

18.      Exhibit C shall be amended by deleting the "Internet Website
Development and Services" section.

19.      Exhibit E shall be replaced with the attached Exhibit E.

20.      Exhibits H, H1, H2 and H3 shall be deleted in their entirety.

21.      All terms of the Agreement not specifically altered by this Amendment
remain in full force and effect.  Any capitalized terms not defined in this
Amendment shall have such meanings as are set forth in the Agreement.




         IN WITNESS WHEREOF, the parties have caused this Amendment to be
executed by their authorized representatives as of the date set forth above.

HCA - INFORMATION TECHNOLOGY            LIFEPOINT HOSPITALS, INC.
& SERVICES, INC.

By: /s/ Noel Williams                   By: /s/ Kenneth C. Donahey
    ------------------------                ---------------------------
Title: President                        Title: Chairman, CEO and President

Date: 4/28/04                           Date: April 28, 2004

<PAGE>

                                    EXHIBIT A

                              SOFTWARE/APPLICATIONS

                                CLINICAL SYSTEMS
                 CLINICAL PATIENT CARE SYSTEM (CPCS) including:

Abstracting                    Office Automation
Admissions                     Operating Room
Blood Bank                     Order Entry
Central Scheduling             Patholology
ED Tracker                     Patient Care Inquiry
Education                      Patient Transportation
Laboratory/Microbiology        Pharmacy
Medical Records                Quality Management
Micromedix                     Radiology
Nursing                        SNO-MED

                           PATIENT ACCOUNTING SYSTEMS

Patient Accounting             CPCM Contract Profiler
3M Encoder                     Electronic Processing
Avega Decision Support         IMAG- Information Management
Casemix/CHOIS/ORYX/Comet       Mainframe Logging
Collections                    On-Line Cashiering

                       FINANCIAL REPORTING/COMMUNICATIONS

Atlas                          General Ledger
Budget                         QMIRS
Exchange/Outlook               VISTA
FIS

                                     PAYROLL

Benefits                       Payroll
Human Resources

                                ACCOUNTS PAYABLE

Accounts Payable               SMART

                             CORPORATE OFFICE (ONLY)

Resource Control/Contracting Corporate Tax

<PAGE>

Funds Management               Corporate Employment Tax

<PAGE>


                                    EXHIBIT B
                            SYSTEM APPLICATION & FEES

FACILITY APPLICATIONS - CHARGED PER FAMILY*:

<TABLE>
<CAPTION>
                                                          MONTHLY FEES
                               -------------------------------------------------------------------
                                                             ACCOUNTS                     PAYROLL/
                               CLINICAL        PATIENT       PAYABLE/      FINANCIAL       HUMAN
                               SYSTEMS       ACCOUNTING       SMART        REPORTING     RESOURCES
                               -------       ----------       -----        ---------     ---------
<S>                            <C>           <C>             <C>           <C>           <C>
  Up to 50 Licensed Beds       $10,350         $ 8,800        $1,525         $1,500        $  700
  51 to 75 Licensed Beds       $14,100         $12,050        $2,075         $2,050        $  950
 76 to 100 Licensed Beds       $17,875         $15,250        $2,625         $2,600        $1,225
101 to 125 Licensed Beds       $21,600         $18,450        $3,200         $3,150        $1,475
126 to 150 Licensed Beds       $25,400         $21,675        $3,750         $3,700        $1,725
151 to 175 Licensed Beds       $29,150         $24,900        $4,300         $4,225        $2,000
176 to 200 Licensed Beds       $32,925         $28,100        $4,850         $4,775        $2,250
201 to 225 Licensed Beds       $36,700         $31,300        $5,400         $5,325        $2,500
226 to 250 Licensed Beds       $40,450         $34,525        $5,975         $5,875        $2,750
  Over 250 Licensed Beds                   TO BE NEGOTIATED FOR INDIVIDUAL FACILITIES
</TABLE>

                                                        MONTHLY FEE

                        CHARGE PER ESTABLISHED COID     $   150
CORPORATE OFFICE CHARGES:
        BUDGET/RESOURCE CONTROL & CONTRACTING/QMIRS     $ 8,800
                                                TAX     $ 1,250
                                   ACCOUNTS PAYABLE     $ 1,200
                                     GENERAL LEDGER     $ 1,000
                            PAYROLL/HUMAN RESOURCES     $   600
                                   FUNDS MANAGEMENT     $   350
                                                FIS     $   200
                                     EMPLOYMENT TAX     $   200
OTHER SERVICES & SYSTEMS:
                       CENTRAL STATEMENT PROCESSING     $  0.46 Per Statement
                                    STATE REPORTING     $500 Per Submission
                                    COMET 7TH SCOPE     $350 Per Submission
             HARDWARE MAINTENANCE (EXTERNAL VENDOR)     Cost + 5%
                                 DEPOT MAINTENANCE:
                                   3Com Term Server     T & M
                                       Espirit 125C     $12 Per Device Per Year
                                  Falco 5000 Series     $50 Per Device Per Year
                                Wyse 50, 60 and 150     $50 Per Device Per Year
                                TI 810, 880 and 885     $125 Per Device Per Year
                                             TI 830     $75 Per Device Per Year
                                           HP4 Plus     T & M

-------------------------
*As used in this Exhibit, "Family" means those entities consolidated in Level 6
in the Company Master (the table which consists of all identifying information
that defines each ledger); provided, however, that each acute care hospital with
a separate Clinical System implementation must be in a separate family.

<PAGE>

        LAWSON HR/PR                To be determined; provided, however, that
                                    fees will not exceed charges at conversion
                                    plus fifty percent (50%)

<PAGE>

                                    EXHIBIT E

Customer's total base APD's and total cost per APD for computing the minimums:

<TABLE>
<S>                                       <C>
Total base APD's:                            495,824

Total cost per APD:                       $    17.64
                                          ----------

                                          $8,746,335
                                          ----------
</TABLE>