**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C57910 57-91-0 17alpha-Estradiol 0 0 0 0 1.06 0 1.06 C57636 57-63-6 17alpha-Ethinylestradiol 0 0 0 0 1 0 1 C84162 84-16-2 meso-Hexestrol 0 0 0 0 0.993 0 0.993 C56531 56-53-1 Diethylstilbestrol 0 0 0 0 0.943 0.00992 0.943 C50282 50-28-2 17beta-Estradiol 0 0 0 0 0.935 0.0153 0.935 C474862 474-86-2 Equilin 0 0 0 0 0.822 0 0.822 C53167 53-16-7 Estrone 0 0 0 0 0.807 0.00246 0.807 C50271 50-27-1 Estriol 0 0 0 0 0.786 0.0122 0.786 C72333 72-33-3 Mestranol 0 0 0 0 0.742 0 0.742 C17924924 17924-92-4 Zearalenone 0 0 0 0 0.71 0 0.71 C68392358 68392-35-8 4-Hydroxytamoxifen 0 0 0 0 0.0118 0.686 0.686 C82640048 82640-04-8 Raloxifene hydrochloride 0 0 0 0 0.0243 0.671 0.671 C129453618 129453-61-8 Fulvestrant 0 0 0 0 0 0.635 0.635 C50419 50-41-9 Clomiphene citrate 0 0 0 0 0.0293 0.588 0.588 C2971360 2971-36-0 2,2-Bis(4-hydroxyphenyl)-1,1,1-trichloroethane 0 0 0 0 0.568 0.0413 0.568 C1478611 1478-61-1 Bisphenol AF 0 0 0 0 0.552 0.000026 0.552 C54965241 54965-24-1 Tamoxifen citrate 0 0 0 0 0.027 0.546 0.546 C446720 446-72-0 Genistein 0 0 0 0 0.538 0 0.538 C68224 68-22-4 Norethindrone 0 0 0 0 0.524 0 0.524 C58184 58-18-4 17-Methyltestosterone 0 0 0 0 0.495 0 0.495 C77407 77-40-7 Bisphenol B 0 0 0 0 0.491 0.00196 0.491 C10161338 10161-33-8 17beta-Trenbolone 0 0 0 0 0.475 0 0.475 C80057 80-05-7 Bisphenol A 0 0 0 0 0.45 0 0.45 C10540291 10540-29-1 Tamoxifen 0 0 0 0 0.0199 0.447 0.447 C486668 486-66-8 Daidzein 0 0 0 0 0.44 0 0.44 C84852153 84852-15-3 4-Nonylphenol, branched 0 0 0 0 0.435 3.92E-07 0.435 C105624860 105624-86-0 5HPP-33 0 0 0 0 0.418 0 0.418 C104438 104-43-8 4-Dodecylphenol 0 0 0 0 0.41 0 0.41 C521186 521-18-6 5alpha-Dihydrotestosterone 0 0 0 0 0.4 0 0.4 C131555 131-55-5 2,2',4,4'-Tetrahydroxybenzophenone 0 0 0 0 0.397 8.24E-08 0.397 C797637 797-63-7 Norgestrel 0 0 0 0 0.394 0 0.394 C140669 140-66-9 4-(1,1,3,3-Tetramethylbutyl)phenol 0 0 0 0 0.393 0 0.393 C27193868 27193-86-8 Dodecylphenol 0 0 0 0 0.392 0 0.392 C57852 57-85-2 Testosterone propionate 0 0 0 0 0.392 0 0.392 C789026 789-02-6 o,p'-DDT 0 0 0 0 0.385 0 0.385 C58720 58-72-0 Triphenylethylene 0 0 0 0 0.383 0 0.383 EPA has made all reasonable efforts ensuring the accuracy of these chemical or substance bioactivity data. These data are still considered iterative and intended for review and comment purposes only. Data presented should not be taken as final decisions regarding potential bioactivity, exposure, hazard or risk of the chemical or substance, or that the EPA has or w ill make a determination that any use of the chemicals or substances necessarily w ill pose a risk. These data do not provide a scientific basis, by themselves, supporting a conclusion that chemicals or substances have potential for endocrine disruption. EPA wi ll continue to update high throughput data and computational models for chemicals and substances in the Endocrine Disruptor Screening Program (http://w ww. epa.gov/endo/).

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 1**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C599644 599-64-4 4-Cumylphenol 0 0 0 0 0.376 6.62E-08 0.376 C5153253 5153-25-3 2-Ethylhexylparaben 0 0 0 0 0.37 0.000486 0.37 C53430 53-43-0 Dehydroepiandrosterone 0 0 0 0 0.365 3.01E-07 0.365 C491805 491-80-5 Biochanin A 0 0 0 0 0.356 0 0.356 C68962 68-96-2 17alpha-Hydroxyprogesterone 0 0 0 0 0.343 0 0.343 C27955948 27955-94-8 4,4',4-Ethane-1,1,1-triyltriphenol 0 0 0 0 0.319 5.19E-07 0.319 C84371653 84371-65-3 Mifepristone 0 0 0 0 0.00255 0.308 0.308 C520365 520-36-5 Apigenin 0 0 0 0 0.307 0 0.307 C80466 80-46-6 4-(2-Methylbutan-2-yl)phenol 0 0 1 0 0.282 0.000192 0.282 C77098 77-09-8 Phenolphthalein 0 0 0 0 0.276 2.61E-07 0.276 C17696627 17696-62-7 Phenylparaben 0 0 0 0 0.275 5.68E-07 0.275 C1085127 1085-12-7 Heptylparaben 0 0 0 0 0.269 0 0.269 C1219381 1219-38-1 Octy lparaben 0 0 0 0 0.268 0 0.268 C131566 131-56-6 2,4-Dihydroxybenzophenone 0 0 0 0 0.266 3.25E-07 0.266 C80091 80-09-1 4,4'-Sulfonyldiphenol 0 0 0 0 0.263 0 0.263 C72435 72-43-5 Methoxychlor 0 0 1 0 0.254 0 0.254 C520183 520-18-3 Kaempferol 0 0 0 0 0.252 0 0.252 C94268 94-26-8 Butylparaben 0 0 0 0 0.251 5.16E-07 0.251 C6088513 6088-51-3 6-Hydroxy-2-naphthyl disulfide 0 0 0 0 0.25 0 0.25 C57114 57-11-4 Octadecanoic acid 0 0 0 1 0.248 0 0.248 C5349519 5349-51-9 4-(2-Methylbutan-2-yl)cyclohexanol 0 0 0 0 0.248 0 0.248 C13463417 13463-41-7 Zinc pyrithione 0 0 1 0 0 0.237 0.237 C53190 53-19-0 o,p'-DDD 0 0 0 0 0.236 0 0.236 C94188 94-18-8 Benzylparaben 0 0 0 0 0.234 0.000859 0.234 C62924703 62924-70-3 Flumetralin 0 0 1 0 0.224 0 0.224 C683181 683-18-1 Dibutyltin dichloride 0 0 0 0 0.000186 0.222 0.222 C92693 92-69-3 4-Phenylphenol 0 0 0 0 0.219 8.63E-08 0.219 C80433 80-43-3 Dicumyl peroxide 0 0 0 0 0.216 0 0.216 C94133 94-13-3 Propylparaben 0 0 0 1 0.205 0 0.205 C67485294 67485-29-4 Hydramethylnon 0 0 1 0 0.2 0 0.2 C50293 50-29-3 p,p'-DDT 0 0 0 0 0.19 0 0.19 C79958 79-95-8 2,2',6,6'-Tetrachlorobisphenol A 0 0 0 0 0.19 0 0.19 C63058 63-05-8 4-Androstene-3,17-dione 0 0 0 0 0.183 0 0.183 C4342363 4342-36-3 Tributyltin benzoate 0 0 0 0 0 0.18 0.18 C85687 85-68-7 Butyl benzyl phthalate 1* 0 0 0 0.179 0 0.179 C51241 51-24-1 Tiratricol 0 0 0 0 0.179 3.24E-07 0.179 C126001 126-00-1 Diphenolic acid 0 0 0 0 0.174 0 0.174 C143500 143-50-0 Kepone 0 0 0 0 0.174 0.0149 0.174 C62384 62-38-4 Phenylmercuric acetate 0 0 0 0 0 0.164 0.164 C99718 99-71-8 4-(Butan-2-yl)phenol 0 0 0 1 0.163 0 0.163

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 2**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C18979550 18979-55-0 4-(Hexyloxy)phenol 0 0 0 0 0.161 3.4E-08 0.161 C98544 98-54-4 4-tert-Butylphenol 0 0 0 0 0.161 0 0.161 C989388 989-38-8 Rhodamine 6G 0 0 0 0 0 0.158 0.158 C14816183 14816-18-3 Phoxim 0 0 0 0 0.156 0 0.156 C2919666 2919-66-6 Melengestrol acetate 0 0 0 0 0.155 0 0.155 C25155184 25155-18-4 Methylbenzethonium chloride 0 0 1 0 0.00822 0.152 0.152 C6683198 6683-19-8 Irganox 1010 0 0 0 1 0.149 0 0.149 C124221 124-22-1 1-Dodecanamine 0 0 0 0 0.149 0 0.149 C126833178 126833-17-8 Fenhexamid 0 0 1 0 0.148 0 0.148 C66819 66-81-9 Cycloheximide 0 0 0 0 0 0.146 0.146 C51525 51-52-5 6-Propyl-2-thiouracil 0 0 0 0 0.144 0 0.144 C612828 612-82-8 3,3'-Dimethylbenzidine dihydrochloride 0 0 0 0 0.143 0.000299 0.143 C4712554 4712-55-4 Diphenyl phosphite 0 0 0 0 0.142 0 0.142 C97563 97-56-3 2-Amino-5-azotoluene 0 0 0 0 0.142 0 0.142 C141797 141-79-7 4-Methylpent-3-en-2-one 0 0 0 1 0.14 0.000626 0.14 C119937 119-93-7 3,3'-Dimethylbenzidine 0 0 0 0 0.139 0 0.139 C92046 92-04-6 2-Chloro-4-phenylphenol 0 0 0 0 0.138 0 0.138 C6055192 6055-19-2 Cyclophosphamide monohydrate 0 0 0 0 0.135 0 0.135 C6893023 6893-02-3 3,5,3'-Triiodothyronine 0 0 0 0 0.135 0 0.135 C480400 480-40-0 Chrysin 0 0 0 0 0.134 0 0.134 C56951 56-95-1 Chlorhexidine diacetate 0 0 1 0 0.00201 0.132 0.132 C2155706 2155-70-6 Tributyltin methacrylate 0 0 0 0 0 0.132 0.132 C1806264 1806-26-4 4-Octy lphenol 0 0 0 0 0.118 0 0.118 C842079 842-07-9 C.I. Solvent Yellow 14 0 0 0 0 0.117 0 0.117 C3319311 3319-31-1 Tris(2-ethylhexyl) trimellitate 0 0 0 0 0.115 0 0.115 C1461229 1461-22-9 Tributyltin chloride 0 0 0 0 0 0.114 0.114 C1987504 1987-50-4 4-Heptylphenol 0 0 0 0 0.113 0 0.113 C1638228 1638-22-8 4-Butylphenol 0 0 0 1 0.111 0 0.111 C90357065 90357-06-5 Bicalutamide 0 0 0 0 0.00307 0.107 0.107 C60168889 60168-88-9 Fenarimol 0 0 0 0 0.105 0.000907 0.105 C140103 140-10-3 Cinnamic acid 0 0 0 1 0.101 0 0.101 C117395 117-39-5 Quercetin 0 0 0 0 0.101 0 0.101 C960714 960-71-4 Triphenylborane 0 0 0 0 0.101 0 0.101 C96489713 96489-71-3 Pyridaben 0 0 1 0 0.1 0 0.1 C500389 500-38-9 Nordihydroguaiaretic acid 0 0 0 0 0.0998 0.0158 0.0998 C53032 53-03-2 Prednisone 0 0 0 0 0.0991 0 0.0991 C563122 563-12-2 Ethion 0 0 0 0 0.0974 0 0.0974 C6344678 6344-67-8 3-Hydroxyfluorene 0 0 0 0 0.0945 0 0.0945 C124947 124-94-7 Triamcinolone 0 0 0 0 0.0939 0 0.0939 C81741288 81741-28-8 Tributyltetradecylphosphonium chloride 0 0 1 0 0.093 0.0244 0.093

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 3**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C1072157 1072-15-7 Sulfuric acid, monononyl ester, sodium salt 0 0 0 0 0.093 0 0.093 C654055013 654055-01-3 Morin hydrate 0 0 0 0 0.0898 0 0.0898 C9004824 9004-82-4 Sodium lauryl polyoxyethylene ether sulfate 0 0 0 1 0.00534 0.0892 0.0892 C104405 104-40-5 4-Nonylphenol 0 0 0 0 0.088 0 0.088 C53939289 53939-28-9 (Z)-11-Hexadecenal 0 0 1 0 0.0879 0 0.0879 C2440224 2440-22-4 2-(2H-Benzotriazol-2-yl)-4-methylphenol 0 0 0 1 0.0875 0 0.0875 C135193 135-19-3 2-Naphthalenol 0 0 0 0 0.0874 0 0.0874 C2104645 2104-64-5 EPN 0 0 0 0 0.0868 0 0.0868 C288104790 288104-79-0 Surinabant 0 0 0 0 0.0866 0 0.0866 C78473719 78473-71-9 Enterolactone 0 0 0 0 0.0866 0 0.0866 C120478 120-47-8 Ethylparaben 0 0 0 0 0.0864 2.69E-08 0.0864 C7173515 7173-51-5 Didecyldimethylammonium chloride 0 0 1 1 0.00313 0.085 0.085 C57090 57-09-0 Hexadecyltrimethylammonium bromide 0 0 0 0 0.000761 0.0837 0.0837 C102676313 102676-31-3 Fadrozole hydrochloride 0 0 0 0 0.0825 0 0.0825 C29091212 29091-21-2 Prodiamine 0 0 1 0 0.00775 0.0823 0.0823 C35256850 35256-85-0 Butam 0 0 0 0 0.0822 0 0.0822 C319857 319-85-7 beta-Hexachlorocyclohexane 0 0 0 0 0.082 0 0.082 C676116044 676116-04-4 PD 0343701 0 0 0 0 0 0.0799 0.0799 C1166525 1166-52-5 Dodecyl gallate 0 0 0 0 0.0000527 0.0773 0.0773 C1034011 1034-01-1 Octy l gallate 0 0 0 0 0.0144 0.0768 0.0768 C18924668 18924-66-8 2,2'-(Tetradecylimino)diethanol 0 0 0 0 0 0.0742 0.0742 C120569 120-56-9 Triethylene glycol dibenzoate 0 0 0 0 0.0732 0 0.0732 C72548 72-54-8 p,p'-DDD 0 0 0 0 0.0728 0 0.0728 C8001545 8001-54-5 Benzalkonium chloride 0 0 1 0 0 0.0727 0.0727 C5137553 5137-55-3 Methyltrioctylammonium chloride 0 0 0 0 0.00331 0.0697 0.0697 C136776 136-77-6 4-Hexylresorcinol 0 0 0 0 0.0687 0.00583 0.0687 C72559 72-55-9 p,p'-DDE 0 0 0 0 0.0677 0 0.0677 C2390605 2390-60-5 Basic Blue 7 0 0 0 0 0 0.0669 0.0669 C24169026 24169-02-6 Econazole nitrate 0 0 0 0 0 0.0666 0.0666 C143390890 143390-89-0 Kresoxim-methyl 0 0 1 0 0.0154 0.066 0.066 C60093 60-09-3 4-Aminoazobenzene 0 0 0 0 0.0658 0 0.0658 C13826352 13826-35-2 3-Phenoxybenzenemethanol 0 0 0 0 0.0657 0 0.0657 C40487421 40487-42-1 Pendimethalin 0 0 1 0 0.0656 0.000214 0.0656 C603350 603-35-0 Triphenylphosphine 0 0 0 0 0.0652 0.00198 0.0652 C64359815 64359-81-5 4,5-Dichloro-2-octyl-3(2H)-isothiazolone 0 0 1 0 0.00534 0.0651 0.0651 C110974 110-97-4 Diisopropanolamine 0 0 0 1 0.0651 0 0.0651 C131577 131-57-7 2-Hydroxy-4-methoxybenzophenone 0 0 0 0 0.0645 0 0.0645 C137304 137-30-4 Ziram 0 1 1 0 0 0.0644 0.0644 C13680358 13680-35-8 4,4'-Methylenebis(2,6-diethylaniline) 0 0 0 0 0.0000111 0.0644 0.0644 C97234 97-23-4 Dichlorophen 0 0 0 0 0.0058 0.0643 0.0643

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 4**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C115866 115-86-6 Triphenyl phosphate 0 0 0 0 0.0641 0.0314 0.0641 C249296433 249296-43-3 CJ-013610 0 0 0 0 0.0000443 0.0638 0.0638 C97007 97-00-7 1-Chloro-2,4-dinitrobenzene 0 0 0 0 0 0.0638 0.0638 C959988 959-98-8 Endosulfan I 0 0 0 0 0.0619 0 0.0619 C496468 496-46-8 Glycoluril 0 0 0 0 0.0207 0.0618 0.0618 C51632167 51632-16-7 1-(Bromomethyl)-3-phenoxybenzene 0 0 0 0 0.0607 0 0.0607 C121799 121-79-9 Propyl gallate 0 0 0 1 0.0601 0 0.0601 C180084019 180084-01-9 SB236057A 0 0 0 0 0 0.0595 0.0595 C61734 61-73-4 Methylene blue 0 0 0 1 0.00154 0.0591 0.0591 C26027383 26027-38-3 Polyoxyethylene(10)nonylphenyl ether 0 0 0 1 0.0406 0.0575 0.0575 C120149 120-14-9 Veratraldehyde 0 0 0 1 0.0572 0 0.0572 C5915413 5915-41-3 Terbuthylazine 0 0 1 0 0.057 0 0.057 C32388559 32388-55-9 1-Cedr-8-en-9-ylethanone 0 0 0 1 0.0562 0 0.0562 C155990208 155990-20-8 SR271425 0 0 0 0 0.0558 0 0.0558 C66575299 66575-29-9 Forskolin 0 0 0 0 0.0528 0 0.0528 C131341861 131341-86-1 Fludioxonil 0 0 1 0 0.0521 0 0.0521 C101611 101-61-1 4,4'-Methylenebis(N,N-dimethylaniline) 0 0 0 0 0.0518 0 0.0518 C84742 84-74-2 Dibutyl phthalate 1* 0 0 0 0.0265 0.0509 0.0509 C57830 57-83-0 Progesterone 0 0 0 0 0.0507 0.000618 0.0507 C120467 120-46-7 1,3-Diphenyl-1,3-propanedione 0 0 0 0 0.0491 0 0.0491 C92682 92-68-2 4-Cyclohexylcyclohexanone 0 0 0 0 0.0491 0 0.0491 C87183 87-18-3 4-tert-Butylphenyl salicylate 0 0 0 0 0.0488 0 0.0488 C13071799 13071-79-9 Terbufos 0 1 1 0 0.0482 0 0.0482 C99865 99-86-5 alpha-Terpinene 0 0 0 1 0.0161 0.0482 0.0482 C484173 484-17-3 9-Phenanthrol 0 0 0 0 0 0.0482 0.0482 C26264062 26264-06-2 Calcium dodecylbenzene sulfonate 0 0 0 1 0 0.0477 0.0477 C6459945 6459-94-5 C.I. Acid Red 114 0 0 0 0 0 0.0473 0.0473 C39300453 39300-45-3 Dinocap 0 0 0 0 0 0.0465 0.0465 C27306781 27306-78-1 Silwet L77 0 0 0 1 0.000232 0.0464 0.0464 C81903 81-90-3 Phenolphthalin 0 0 0 0 0.0459 0 0.0459 C838880 838-88-0 4,4'-Methylenebis(2-methylaniline) 0 0 0 0 0.0458 0.0113 0.0458 C96833 96-83-3 Iopanoic acid 0 0 0 0 0.0454 0 0.0454 C117793 117-79-3 2-Aminoanthraquinone 0 0 0 0 0.0453 0 0.0453 C67301 67-30-1 Tetrac 0 0 0 0 0 0.045 0.045 C41481667 41481-66-7 4,4'-Sulfonylbis[2-(prop-2-en-1-yl)phenol] 0 0 0 0 0.0231 0.0449 0.0449 C88040 88-04-0 4-Chloro-3,5-dimethylphenol 0 0 1 0 0.0439 0 0.0439 C16587716 16587-71-6 4-(tert-Pentyl)-cyclohexanone 0 0 0 1 0.0437 0.0000301 0.0437 C868859 868-85-9 Dimethyl hydrogen phosphite 0 0 0 0 0.0148 0.0437 0.0437 C41372207 41372-20-7 Apomorphine hydrochloride hydrate 0 0 0 0 0.00617 0.0435 0.0435 C33629479 33629-47-9 Butralin 0 0 1 0 0.0426 0 0.0426

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 5**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C525826 525-82-6 Flavone 0 0 0 0 0.0423 0 0.0423 C143748 143-74-8 Phenol red 0 0 0 0 0.0409 0 0.0409 C52686 52-68-6 Trichlorfon 0 0 1 0 0.0405 0.00361 0.0405 C88608 88-60-8 2-tert-Butyl-5-methylphenol 0 0 0 1 0.0402 0 0.0402 C119619 119-61-9 Benzophenone 0 0 0 1 0.04 0 0.04 C1861401 1861-40-1 Benfluralin 1 0 1 0 0.0398 5.32E-07 0.0398 C21145777 21145-77-7 6-Acetyl-1,1,2,4,4,7-hexamethyltetralin 0 0 0 1 0.0388 0 0.0388 C90302 90-30-2 N-Phenyl-1-naphthylamine 0 0 0 0 0.0386 0 0.0386 C8007703 8007-70-3 Anise oil 0 0 0 1 0.0384 0.00206 0.0384 C156052685 156052-68-5 Zoxamide 0 0 1 0 0 0.038 0.038 C131180 131-18-0 Dipentyl phthalate 0 0 0 0 0.0125 0.0376 0.0376 C84695 84-69-5 Diisobutyl phthalate 0 0 0 0 0.0283 0.0375 0.0375 C133855988 133855-98-8 Epoxiconazole 0 0 0 0 0 0.0372 0.0372 C33820530 33820-53-0 Isopropalin 0 0 0 0 0.0122 0.0372 0.0372 C56553 56-55-3 Benz(a)anthracene 0 0 0 0 0.0372 0 0.0372 C827214 827-21-4 Benzenesulfonic acid, 2,4-dimethyl-, sodium salt 0 0 0 1 0.0123 0.0365 0.0365 C33228454 33228-45-4 4-Hexylaniline 0 0 0 0 0.00955 0.0357 0.0357 C121552612 121552-61-2 Cyprodinil 0 0 1 0 0.0356 0 0.0356 C2321075 2321-07-5 Fluorescein 0 0 0 0 0.00451 0.0354 0.0354 C120321 120-32-1 Clorophene 0 0 1 0 0.0353 0.018 0.0353 C22260511 22260-51-1 Bromocriptine mesylate 0 0 0 0 0 0.0351 0.0351 C744456 744-45-6 Diphenyl isophthalate 0 0 0 0 0.035 0 0.035 C55283686 55283-68-6 Ethalfluralin 0 0 1 0 0.0346 0 0.0346 C1582098 1582-09-8 Trifluralin 1 0 1 0 0.0337 0 0.0337 C60333 60-33-3 Linoleic acid 0 0 0 1 0 0.0336 0.0336 C27176870 27176-87-0 Dodecylbenzenesulfonic acid 0 0 1 1 0.000491 0.0328 0.0328 C31519229 31519-22-9 1,4-Dihydroxy-2-naphthoic acid 0 0 0 0 0 0.0324 0.0324 C2457014 2457-01-4 Barium bis(2-ethylhexanoate) 0 0 0 0 0.011 0.032 0.032 C111717 111-71-7 Heptanal 0 0 0 1 0.0319 0 0.0319 C1596845 1596-84-5 Daminozide 0 0 1 0 0.0318 0.000412 0.0318 C69806402 69806-40-2 Haloxyfop-methyl 0 0 0 0 0 0.0317 0.0317 C125116236 125116-23-6 Metconazole 0 0 1 0 0.0105 0.0316 0.0316 C63449412 63449-41-2 C8-18-Alkydimethylbenzyl ammonium chlorides 0 0 1 0 0.0312 0.029 0.0312 C122453730 122453-73-0 Chlorfenapyr 0 0 1 0 0 0.0311 0.0311 C88302 88-30-2 3-Trifluoromethyl-4-nitrophenol 0 0 1 0 0.00604 0.0311 0.0311 C3691358 3691-35-8 Chlorophacinone 0 0 1 0 0 0.0307 0.0307 C107302 107-30-2 Chloromethyl methyl ether 0 0 0 0 0.0306 0 0.0306 C2467029 2467-02-9 Bisphenol F 0 0 0 0 0.0303 0 0.0303 C115297 115-29-7 Endosulfan 1* 0 0 0 0.0295 0 0.0295 C106489 106-48-9 4-Chlorophenol 0 0 0 0 0.0293 0.00838 0.0293

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 6**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C754916 754-91-6 PFOSA 0 0 0 0 0.024 0.029 0.029 C69749 69-74-9 Cytarabine hydrochloride 0 0 0 0 0.0289 0 0.0289 C90028 90-02-8 Salicylaldehyde 0 0 0 1 0.0288 0 0.0288 C941695 941-69-5 1-Phenyl-1H-pyrrole-2,5-dione 0 0 0 0 0 0.0288 0.0288 C50146 50-14-6 Ergocalciferol 0 0 0 0 0 0.0286 0.0286 C59507 59-50-7 4-Chloro-3-methylphenol 0 0 1 0 0.0285 1.91E-07 0.0285 C55406536 55406-53-6 3-Iodo-2-propynyl-N-butylcarbamate 0 0 1 0 0 0.0283 0.0283 C156105 156-10-5 4-Nitrosodiphenylamine 0 0 0 0 0.028 0.0138 0.028 C645567 645-56-7 4-Propylphenol 0 0 0 1 0.0275 0 0.0275 C2772454 2772-45-4 2,4-Bis(1-methyl-1-phenylethyl)phenol 0 0 0 0 0.0274 0 0.0274 C79241466 79241-46-6 Fluazifop-P-butyl 0 0 1 0 0.0272 0 0.0272 C6846500 6846-50-0 2,2,4-Trimethyl-1,3-pentanediol diisobutyrate 0 0 0 0 0.0272 0 0.0272 C127308821 127308-82-1 Zamifenacin 0 0 0 0 0.0271 0 0.0271 C94361065 94361-06-5 Cyproconazole 0 0 1 0 0.0268 0 0.0268 C2554065 2554-06-5 1,3,5,7-Tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane 0 0 0 0 0.0268 0 0.0268 C3383968 3383-96-8 Temephos 0 0 1 0 0.00268 0.0264 0.0264 C95737681 95737-68-1 Pyriproxyfen 1 0 1 0 0.0259 0 0.0259 C82385420 82385-42-0 Sodium saccharin hydrate 0 0 0 0 0.0257 0 0.0257 CNOCAS47353 NOCAS_47353 SSR241586 0 0 0 0 0 0.0255 0.0255 C705602 705-60-2 (2-Nitro-1-propenyl)benzene 0 0 0 0 0.000043 0.0254 0.0254 C2433149 2433-14-9 4-Cyclohexylcyclohexanol 0 0 0 0 0.0253 0 0.0253 C298044 298-04-4 Disulfoton 1* 0 0 0 0.025 0 0.025 C158081993 158081-99-3 CP-105696 0 0 0 0 0 0.0249 0.0249 C585342 585-34-2 3-tert-Butylphenol 0 0 0 1 0.0248 0 0.0248 C141220 141-22-0 9-Octadecenoic acid, 12-hydroxy-, (9Z,12R)- 0 0 0 0 0 0.0246 0.0246 C668981020 668981-02-0 CP-863187 0 0 0 0 0 0.0245 0.0245 C333415 333-41-5 Diazinon 1 0 1 0 0.0237 0 0.0237 C2396681 2396-68-1 4-tert-Butylbenzenethiol 0 0 0 0 0.0234 0.000346 0.0234 C90153 90-15-3 1-Naphthol 0 0 0 0 0.0232 0 0.0232 C115322 115-32-2 Dicofol 1* 0 0 0 0 0.0229 0.0229 C451401 451-40-1 1,2-Diphenylethanone 0 0 0 0 0.0227 0 0.0227 C144627 144-62-7 Oxalic acid 0 0 1 1 0.00766 0.0225 0.0225 C135206 135-20-6 Cupferron 0 0 0 0 0.0224 0 0.0224 C1724396 1724-39-6 Cyclododecanol 0 0 0 0 0.0221 0 0.0221 C118569 118-56-9 3,3,5-Trimethylcyclohexyl salicylate 0 0 0 0 0.0217 0 0.0217 C3025307 3025-30-7 Ethyl (2E,4Z)-deca-2,4-dienoate 0 0 1 1 0 0.0214 0.0214 C84617 84-61-7 Dicyclohexyl phthalate 0 0 0 0 0.0199 0.0213 0.0213 C171866312 171866-31-2 CP-283097 0 0 0 0 0.0212 0 0.0212 C99898 99-89-8 4-Isopropylphenol 0 0 0 0 0.021 0 0.021 C375951 375-95-1 PFNA 0 0 0 0 0.00751 0.0209 0.0209

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 7**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C101815 101-81-5 Diphenylmethane 0 0 0 1 0.0207 0 0.0207 C4291638 4291-63-8 Cladribine 0 0 0 0 0.0207 0 0.0207 C54593838 54593-83-8 Chlorethoxyfos 0 0 1 0 0.0203 0 0.0203 C630568 630-56-8 Hydroxyprogesterone caproate 0 0 0 0 0.0177 0.0202 0.0202 C106503 106-50-3 1,4-Benzenediamine 0 0 0 0 0.0201 0.0158 0.0201 C120511731 120511-73-1 Anastrozole 0 0 0 0 0.0201 0 0.0201 C5116949 5116-94-9 Monotridecyl phosphate 0 0 0 0 0 0.0199 0.0199 C105555 105-55-5 N,N'-Diethylthiourea 0 0 0 0 0.0196 0 0.0196 C96708 96-70-8 2-tert-Butyl-4-ethylphenol 0 0 0 0 0.0193 0 0.0193 C57749 57-74-9 Chlordane 0 0 0 0 0.0191 0 0.0191 C712505 712-50-5 Cyclohexylphenylketone 0 0 0 0 0.0191 0 0.0191 C55219653 55219-65-3 Triadimenol 0 0 1 0 0.0188 0 0.0188 C3026639 3026-63-9 Sodium tridecyl sulfate 0 0 0 0 0 0.0186 0.0186 C25155300 25155-30-0 Sodium dodecylbenzenesulfonate 0 0 1 1 0 0.0185 0.0185 C127515 127-51-5 alpha-Isomethylionone 0 0 0 1 0.0185 0 0.0185 C179465715 179465-71-5 CJ-013790 0 0 0 0 0.0185 0 0.0185 C135080034 135080-03-4 CP-100829 0 0 0 0 0 0.0184 0.0184 C97886458 97886-45-8 Dithiopyr 0 0 1 0 0.0183 0 0.0183 C92875 92-87-5 Benzidine 0 0 0 0 0.0183 0 0.0183 C102761 102-76-1 Triacetin 0 0 0 1 0.0182 0 0.0182 C298022 298-02-2 Phorate 0 0 1 0 0.0181 0 0.0181 C60571 60-57-1 Dieldrin 0 0 0 0 0.0181 0 0.0181 C110258 110-25-8 Oleyl sarcosine 0 0 0 1 0 0.018 0.018 C29232937 29232-93-7 Pirimiphos-methyl 0 0 1 0 0.0176 0 0.0176 C139139 139-13-9 Nitrilotriacetic acid 0 0 0 0 0.0176 0 0.0176 C262376750 262376-75-0 HMR1426 0 0 0 0 0.0176 0 0.0176 C106309 106-30-9 Ethyl heptanoate 0 0 0 1 0.0173 0 0.0173 C6259763 6259-76-3 Hexyl salicylate 0 0 0 1 0.0173 0 0.0173 C2110181 2110-18-1 2-(3-Phenylpropyl)pyridine 0 0 0 0 0.0171 0 0.0171 CNOCAS47364 NOCAS_47364 SSR103800 0 0 0 0 0 0.0171 0.0171 C143077 143-07-7 Dodecanoic acid 0 0 0 1 0 0.017 0.017 C14371109 14371-10-9 (2E)-3-Phenylprop-2-enal 0 0 0 0 0.0167 0 0.0167 C125225287 125225-28-7 Ipconazole 0 0 1 0 0 0.0166 0.0166 C4574043 4574-04-3 My risty ltrimethylammonium chloride 0 0 0 0 0.0071 0.0166 0.0166 C161326347 161326-34-7 Fenamidone 0 0 1 0 0.0164 0.0000211 0.0164 C2491385 2491-38-5 2-Bromo-4-hydroxyacetophenone 0 0 1 0 0.0164 0 0.0164 C2409554 2409-55-4 2-tert-Butyl-4-methylphenol 0 0 0 1 0 0.0164 0.0164 C4602840 4602-84-0 Farnesol 0 0 1 1 0.0162 0 0.0162 C169590425 169590-42-5 Celecoxib 0 0 0 0 0 0.0159 0.0159 C78637 78-63-7 2,5-Dimethyl-2,5-di-(tert-butylperoxy)hexane 0 0 0 0 0.0159 0 0.0159

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 8**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C25956176 25956-17-6 Allura Red C.I.16035 0 0 0 1 0 0.0157 0.0157 C117997 117-99-7 2-Hydroxybenzophenone 0 0 0 0 0.0157 0 0.0157 C107982 107-98-2 1-Methoxy-2-propanol 0 0 0 1 0.0156 0.0000338 0.0156 C120809 120-80-9 Catechol 0 0 0 0 0.0155 0 0.0155 C108214 108-21-4 Isopropyl acetate 0 0 0 1 0.0152 0.000759 0.0152 C65277421 65277-42-1 Ketoconazole 0 0 0 0 0 0.015 0.015 C678397 678-39-7 1,1,2,2-Tetrahydroperfluoro-1-decanol 0 0 0 0 0.0146 0 0.0146 C95385 95-38-5 1H-Imidazole-1-ethanol, 2-(8-heptadecenyl)-4,5-dihydro- 0 0 0 0 0.0142 0.0143 0.0143 C124072 124-07-2 Octanoic acid 0 0 1 1 0.00457 0.0142 0.0142 C131179 131-17-9 Diallyl phthalate 0 0 0 0 0.014 0.00157 0.014 C121006 121-00-6 2-tert-Butyl-4-methoxyphenol 0 0 0 1 0.0139 0 0.0139 C52315078 52315-07-8 Cypermethrin 1 0 1 0 0.0138 0 0.0138 C33228443 33228-44-3 4-Pentylaniline 0 0 0 0 0.0138 0.00901 0.0138 C532274 532-27-4 2-Chloroacetophenone 0 0 0 0 0.0137 0 0.0137 CNOCAS47377 NOCAS_47377 AVE6324 0 0 0 0 0.0137 0 0.0137 CNOCAS47387 NOCAS_47387 SAR102779 0 0 0 0 0.000059 0.0137 0.0137 C2144538 2144-53-8 Tridecafluorohexylethyl methacrylate 0 0 0 0 0.0134 0 0.0134 C118581 118-58-1 Benzyl salicylate 0 0 0 1 0.013 0 0.013 C26225796 26225-79-6 Ethofumesate 0 0 1 0 0.00195 0.0129 0.0129 C361343193 361343-19-3 Elzasonan 0 0 0 0 0 0.0129 0.0129 C115399 115-39-9 Bromophenol blue 0 0 0 0 0 0.0128 0.0128 C112281773 112281-77-3 Tetraconazole 0 0 1 0 0 0.0127 0.0127 C2921882 2921-88-2 Chlorpyrifos 1 0 1 0 0.0125 0 0.0125 C97541 97-54-1 Isoeugenol 0 0 0 1 0.0124 0.00199 0.0124 C159138815 159138-81-5 Cariporide mesylate 0 0 0 0 0.0124 3.21E-07 0.0124 C203942498 203942-49-8 UK-337312 0 0 0 0 0.0021 0.0124 0.0124 C4638486 4638-48-6 5-Chlorosalicylanilide 0 0 0 0 0 0.0122 0.0122 C92842 92-84-2 Phenothiazine 0 0 0 0 0.0122 0 0.0122 C68959206 68959-20-6 Disiquonium chloride 0 0 0 0 0.0121 0.0019 0.0121 C89872 89-87-2 1,3-Dimethyl-4-nitrobenzene 0 0 0 0 0.0121 0 0.0121 C205992 205-99-2 Benzo(b)fluoranthene 0 0 0 0 0.012 0 0.012 C95749 95-74-9 3-Chloro-4-methylaniline 0 0 0 0 0.00428 0.012 0.012 CNOCAS47334 NOCAS_47334 MK-968 0 0 0 0 0 0.0119 0.0119 C39515418 39515-41-8 Fenpropathrin 0 0 1 0 0.0117 0 0.0117 C95136 95-13-6 Indene 0 0 0 1 0.0117 0 0.0117 C1241947 1241-94-7 2-Ethylhexyl diphenyl phosphate 0 0 0 0 0.0117 0 0.0117 C35400432 35400-43-2 Sulprofos 0 0 1 0 0.0115 0 0.0115 C55285148 55285-14-8 Carbosulfan 0 0 0 0 0.0115 0 0.0115 C21245023 21245-02-3 2-Ethylhexyl 4-(dimethylamino)benzoate 0 0 0 0 0.0114 0 0.0114 C14351667 14351-66-7 Sodium abietate 0 0 0 1 0.00244 0.0112 0.0112

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 9**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C120127 120-12-7 Anthracene 0 0 0 0 0.0112 0 0.0112 C1570645 1570-64-5 4-Chloro-2-methylphenol 0 0 0 0 0.0109 4.17E-07 0.0109 C1120043 1120-04-3 Octadecyl sulfate sodium salt 0 0 0 1 0.00252 0.0108 0.0108 C87818313 87818-31-3 Cinmethylin 0 0 0 0 0.0107 0 0.0107 C77838 77-83-8 Ethyl methylphenylglycidate 0 0 0 1 0.00327 0.0102 0.0102 C86306 86-30-6 N-Nitrosodiphenylamine 0 0 0 0 0.0102 0 0.0102 C108463 108-46-3 Resorcinol 0 0 0 0 0.00321 0.0101 0.0101 C1461252 1461-25-2 Tetrabutyltin 0 0 0 0 0 0.0101 0.0101 C101860 101-86-0 2-Benzylideneoctanal 0 0 0 1 0.00983 0 0.00983 C77474 77-47-4 Hexachlorocyclopentadiene 0 1 0 0 0.00973 0 0.00973 C84753 84-75-3 Dihexyl phthalate 0 0 0 0 0.00964 0 0.00964 C27138314 27138-31-4 Di(propylene glycol) dibenzoate 0 0 0 0 0.00955 0 0.00955 C10453868 10453-86-8 Resmethrin 1* 0 0 0 0.00944 0 0.00944 C80262 80-26-2 alpha-Terpinyl acetate 0 0 0 1 0.00943 0 0.00943 C5315797 5315-79-7 1-Hydroxypyrene 0 0 0 0 0.00941 0 0.00941 C116256 116-25-6 1-(Hydroxymethyl)-5,5-dimethylhydantoin 0 0 1 0 0.00936 0 0.00936 C81406373 81406-37-3 Fluroxypyr-meptyl 0 0 1 0 0.00936 0 0.00936 C2058948 2058-94-8 Perfluoroundecanoic acid 0 0 0 0 0.00337 0.00933 0.00933 C605458 605-45-8 Diisopropyl phthalate 0 0 0 0 0.00932 0 0.00932 C108985 108-98-5 Benzenethiol 0 0 0 0 0.00908 0 0.00908 C23184669 23184-66-9 Butachlor 0 0 0 0 0 0.00908 0.00908 C221671621 221671-62-1 SR146131 0 0 0 0 0 0.00907 0.00907 CNOCAS47351 NOCAS_47351 SSR240612 0 0 0 0 0.00262 0.00904 0.00904 C134316 134-31-6 8-Hydroxyquinoline sulfate 0 0 0 0 0.00897 0.00019 0.00897 C79622596 79622-59-6 Fluazinam 0 0 1 0 0 0.00891 0.00891 C117718602 117718-60-2 Thiazopyr 0 0 0 0 0.00886 0 0.00886 C101779 101-77-9 4,4'-Methylenedianiline 0 1 0 0 0.00885 0 0.00885 C63252 63-25-2 Carbaryl 1 0 1 0 0.00877 0 0.00877 C3811732 3811-73-2 Sodium (2-pyridylthio)-N-oxide 0 0 1 0 0 0.00872 0.00872 C8006904 8006-90-4 Peppermint oil 0 0 0 1 0.00851 0 0.00851 C4344552 4344-55-2 4-Butyloxyaniline 0 0 0 0 0.00848 0 0.00848 C23593751 23593-75-1 Clotrimazole 0 0 0 0 0.000434 0.00844 0.00844 C122407 122-40-7 Pentylcinnamaldehyde 0 0 0 1 0.00842 0 0.00842 C586629 586-62-9 Terpinolene 0 0 0 1 0.00827 0 0.00827 C79983714 79983-71-4 Hexaconazole 0 0 0 0 0.000168 0.00822 0.00822 C122394 122-39-4 Diphenylamine 0 0 1 0 0.00816 0 0.00816 C69327760 69327-76-0 Buprofezin 0 0 1 0 0 0.00796 0.00796 C4707475 4707-47-5 Methyl 2,4-dihydroxy-3,6-dimethylbenzoate 0 0 0 1 0.00793 0 0.00793 C104541 104-54-1 3-Phenyl-2-propen-1-ol 0 0 0 1 0.00786 0 0.00786 C618451 618-45-1 3-Isopropylphenol 0 0 0 1 0.00783 0 0.00783

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 10**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C140318 140-31-8 1-(2-Aminoethyl)piperazine 0 0 0 0 0.0078 0 0.0078 C83657243 83657-24-3 Diniconazole 0 0 0 0 0 0.00761 0.00761 C27323417 27323-41-7 Dodecylbenzene sulfonate triethanolamine (1:1) 0 0 0 1 0.0075 0 0.0075 C206440 206-44-0 Fluoranthene 0 0 0 0 0.00745 0 0.00745 C101553 101-55-3 p-Bromodiphenyl ether 0 0 0 0 0.00744 3.71E-07 0.00744 C1024573 1024-57-3 Heptachlor epoxide 0 0 0 0 0.00739 0 0.00739 C290352282 290352-28-2 CP-634384 0 0 0 0 0.00739 0 0.00739 C2550405 2550-40-5 Dicyclohexyl disulfide 0 0 0 0 0.00737 0 0.00737 C99978 99-97-8 N,N,4-Trimethylaniline 0 0 0 0 0.00737 0 0.00737 C99070 99-07-0 3-Dimethylaminophenol 0 0 0 0 0.00715 0 0.00715 C647427 647-42-7 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol 0 0 0 0 0.007 0 0.007 C2425776 2425-77-6 2-Hexyl-1-decanol 0 0 0 0 0.0021 0.00695 0.00695 C7664382 7664-38-2 Phosphoric acid 0 0 1 1 0.0069 0 0.0069 C1671756 1671-75-6 Heptanophenone 0 0 0 0 0.00686 0 0.00686 C289716945 289716-94-5 CP-607366 0 0 0 0 0 0.00686 0.00686 C7487947 7487-94-7 Mercuric chloride 0 0 0 0 0 0.00686 0.00686 C99763 99-76-3 Methylparaben 0 0 0 1 0.00684 1.88E-07 0.00684 C3855321 3855-32-1 2,6,10-Trimethyl-2,6,10-triazaundecane 0 0 0 0 0.00669 0 0.00669 C587655 587-65-5 2-Chloro-N-phenylacetamide 0 0 0 0 0 0.00669 0.00669 C41198087 41198-08-7 Profenofos 0 1 1 0 0.0025 0.00658 0.00658 C107879 107-87-9 2-Pentanone 0 0 0 1 0.00202 0.0065 0.0065 C95954 95-95-4 2,4,5-Trichlorophenol 0 0 0 0 0.00613 0 0.00613 C127253 127-25-3 Methyl abietate 0 0 0 1 0.00607 0 0.00607 C52868 52-86-8 Haloperidol 0 0 0 0 0.00598 0 0.00598 C132649 132-64-9 Dibenzofuran 0 0 0 0 0.00597 0 0.00597 C489010 489-01-0 2,6-Di-tert-butyl-4-methoxyphenol 0 0 0 0 0.00583 0 0.00583 C741582 741-58-2 Bensulide 0 1 1 0 0 0.00571 0.00571 C78422 78-42-2 Tris(2-ethylhexyl) phosphate 0 0 0 1 0.00568 0 0.00568 CNOCAS47389 NOCAS_47389 SAR150640 0 0 0 0 0 0.00566 0.00566 C22839470 22839-47-0 Aspartame 0 0 0 0 0.00559 0 0.00559 C94473 94-47-3 2-Phenylethyl benzoate 0 0 0 1 0.00552 0 0.00552 C90437 90-43-7 2-Phenylphenol 1 0 1 0 0.00543 0 0.00543 C120956 120-95-6 2,4-Bis(2-methylbutan-2-yl)phenol 0 0 0 0 0.00528 0.00113 0.00528 C24549062 24549-06-2 2-Ethyl-6-methylaniline 0 0 0 0 0.00519 0 0.00519 C463401 463-40-1 Linolenic acid 0 0 0 1 0.00166 0.00511 0.00511 C95501 95-50-1 1,2-Dichlorobenzene 0 1 0 0 0.00153 0.00507 0.00507 C725228455 725228-45-5 AVE5638 0 0 0 0 0.00507 0.00382 0.00507 C137268 137-26-8 Thiram 0 0 1 0 0.00506 0 0.00506 C769926 769-92-6 4-tert-Butylaniline 0 0 0 0 0.00506 0 0.00506 C75865 75-86-5 2-Hydroxy-2-methylpropanenitrile 0 0 0 0 0.00499 0 0.00499

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 11**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C2934056 2934-05-6 2,4-Diisopropylphenol 0 0 0 0 0.00488 0 0.00488 C112709 112-70-9 1-Tridecanol 0 0 0 1 0.00481 0 0.00481 C51630581 51630-58-1 Fenvalerate 0 0 0 0 0.00468 0 0.00468 C89838 89-83-8 Thymol 0 0 1 1 0.00465 0 0.00465 C101804 101-80-4 4,4'-Oxy dianiline 0 0 0 0 0.00457 0 0.00457 C3164850 3164-85-0 Potassium 2-ethylhexanoate 0 0 0 0 0.00456 0 0.00456 C112529154 112529-15-4 Pioglitazone hydrochloride 0 0 0 0 0.00454 0 0.00454 C120832 120-83-2 2,4-Dichlorophenol 0 0 0 0 0.00424 2.15E-08 0.00424 C122781 122-78-1 Phenylacetaldehyde 0 0 0 1 0.0042 0 0.0042 C105533 105-53-3 Diethyl propanedioate 0 0 0 1 0.00416 0 0.00416 C1007289 1007-28-9 Deisopropylatrazine 0 0 0 0 0.00394 0 0.00394 C1114712 1114-71-2 Pebulate 0 0 0 0 0.00391 0.0000455 0.00391 C43121433 43121-43-3 Triadimefon 1 0 1 0 0.0039 0 0.0039 C57103 57-10-3 Hexadecanoic acid 0 0 0 1 0.00386 0 0.00386 C199119589 199119-58-9 Trifloxysulfuron-sodium 0 0 0 0 0.00375 0 0.00375 C132650 132-65-0 Dibenzothiophene 0 0 0 0 0.00373 0 0.00373 C94462 94-46-2 Isopentyl benzoate 0 0 0 1 0.00166 0.00371 0.00371 C82688 82-68-8 Pentachloronitrobenzene 1 0 1 0 0.00362 0 0.00362 C104132 104-13-2 4-Butylaniline 0 0 0 0 0.00355 0 0.00355 C2386870 2386-87-0 UT-632 0 0 0 0 0.00355 0 0.00355 C123079 123-07-9 4-Ethylphenol 0 0 0 1 0.00352 0 0.00352 C51229788 51229-78-8 Chloroallyl methenamine chloride 0 0 1 1 0.00109 0.00343 0.00343 C684935 684-93-5 N-Nitroso-N-methylurea 0 0 0 0 0.000967 0.00336 0.00336 C88186 88-18-6 2-tert-Butylphenol 0 0 0 1 0.00325 0 0.00325 C22915737 22915-73-7 Hexane-1,6-diyl dibenzoate 0 0 0 0 0.00322 0 0.00322 C17796826 17796-82-6 N-(Cyclohexylthio)phthalimide 0 0 0 0 0.00292 0.0032 0.0032 C58899 58-89-9 Lindane 0 1 0 0 0.00306 0 0.00306 C108770 108-77-0 2,4,6-Trichloro-s-triazine 0 0 0 0 0.00306 0 0.00306 C39905572 39905-57-2 4-Hexyloxyaniline 0 0 0 0 0.00257 0.00293 0.00293 C1948330 1948-33-0 tert-Buty lhydroquinone 0 0 0 1 0.00291 0 0.00291 C55389 55-38-9 Fenthion 0 0 0 0 0.00263 0 0.00263 C93083 93-08-3 2'-Acetonaphthone 0 0 0 1 0.00257 0 0.00257 C123171 123-17-1 2,6,8-Trimethyl-4-nonanol 0 0 0 0 0.00239 0.0000324 0.00239 C1031078 1031-07-8 Endosulfan sulfate 0 0 0 0 0 0.00235 0.00235 C51036 51-03-6 Piperonyl butoxide 1 0 1 0 0.00231 0 0.00231 C80546 80-54-6 3-(4-tert-Butylphenyl)-2-methylpropanal 0 0 0 1 0.0022 0 0.0022 C27344418 27344-41-8 Disodium 4,4'-bis(2-sulfostyryl)biphenyl 0 0 0 0 0.00215 0 0.00215 C101020 101-02-0 Triphenyl phosphite 0 0 0 0 0.0021 0 0.0021 C6485401 6485-40-1 R-(-)-Carvone 0 0 1 1 0.00195 0 0.00195 C39236469 39236-46-9 Imidazolidinyl urea 0 0 0 0 0.00189 0 0.00189

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 12**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C5437456 5437-45-6 Benzyl bromoacetate 0 0 0 0 0.00188 0 0.00188 C930552 930-55-2 N-Nitrosopyrrolidine 0 0 0 0 0.00171 0 0.00171 C80080 80-08-0 Dapsone 0 0 0 0 0.00158 0 0.00158 C112129 112-12-9 2-Undecanone 0 0 1 1 0.00139 0 0.00139 C51796 51-79-6 Urethane 0 1 0 0 0.00138 0 0.00138 C98730042 98730-04-2 Benoxacor 0 0 0 1 0.000355 0.00117 0.00117 C1763231 1763-23-1 PFOS 0 1 0 0 0.000259 0.00114 0.00114 C119471 119-47-1 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) 0 0 0 0 0.00113 0.000283 0.00113 C604751 604-75-1 Oxazepam 0 0 0 0 0.00109 0 0.00109 C71751412 71751-41-2 Abamectin 1 0 1 0 0 0.000773 0.000773 C1569024 1569-02-4 1-Ethoxy-2-propanol 0 0 0 0 0.000721 0 0.000721 C131807573 131807-57-3 Famoxadone 0 0 1 0 0 0.000714 0.000714 CNOCAS47379 NOCAS_47379 SSR126768 0 0 0 0 0 0.000602 0.000602 C10016203 10016-20-3 alpha-Cyclodextrin 0 0 0 1 0.000384 0.000579 0.000579 C427510 427-51-0 Cyproterone acetate 0 0 0 0 0.000543 0 0.000543 C114369436 114369-43-6 Fenbuconazole 0 0 1 0 0.000538 0 0.000538 C1559359 1559-35-9 2-(2-Ethylhexyloxy)ethanol 0 0 0 0 0.000532 0 0.000532 C101202 101-20-2 Triclocarban 0 0 0 0 0 0.000479 0.000479 C119168773 119168-77-3 Tebufenpyrad 0 0 0 0 0 0.000466 0.000466 C17372871 17372-87-1 Eosin 0 0 0 0 0 0.000439 0.000439 C83794 83-79-4 Rotenone 0 0 1 0 0.000414 0.000154 0.000414 C129179 129-17-9 Sulfan blue 0 0 0 0 0 0.000404 0.000404 C548629 548-62-9 Gentian Violet 0 0 0 0 0 0.000394 0.000394 C3844459 3844-45-9 FD&C Blue No. 1 0 0 1 1 0 0.000382 0.000382 C119446683 119446-68-3 Difenoconazole 0 0 1 0 0 0.000367 0.000367 C1918167 1918-16-7 Propachlor 1* 0 0 0 0 0.000365 0.000365 C26040517 26040-51-7 Bis(2-ethylhexyl) tetrabromophthalate 0 0 0 0 0.000358 0 0.000358 C175013180 175013-18-0 Pyraclostrobin 0 0 1 0 0 0.000357 0.000357 C2465272 2465-27-2 Auramine hydrochloride 0 0 0 0 0 0.000345 0.000345 C611701 611-70-1 Isopropyl phenyl ketone 0 0 0 0 0.00034 0 0.00034 C117428225 117428-22-5 Picoxystrobin 0 0 1 0 0 0.00033 0.00033 C97322877 97322-87-7 Troglitazone 0 0 0 0 0.0000625 0.000321 0.000321 C534521 534-52-1 2-Methyl-4,6-dinitrophenol 0 0 0 0 0 0.000304 0.000304 C2870328 2870-32-8 C.I. Direct Yellow 12 0 0 0 0 0 0.00029 0.00029 C66717 66-71-7 1,10-Phenanthroline 0 0 0 0 0 0.00028 0.00028 C444610917 444610-91-7 PharmaGSID_47315 0 0 0 0 0 0.000279 0.000279 C52017 52-01-7 Spironolactone 0 0 0 0 0.000278 0.00000682 0.000278 CNOCAS34742 NOCAS_34742 Milbemectin (mixture of 70% Milbemcin A4, 30% Milbemycin A3) 0 0 0 0 0 0.000235 0.000235 C302794 302-79-4 trans-Retinoic acid 0 0 0 0 0.000228 0 0.000228 C101542 101-54-2 N-Phenyl-1,4-benzenediamine 0 0 0 0 0.000215 0 0.000215

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 13**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C85509199 85509-19-9 Flusilazole 0 0 0 0 0 0.000202 0.000202 C76879 76-87-9 Triphenyltin hydroxide 0 1 1 0 0 0.000198 0.000198 C20265978 20265-97-8 4-Methoxyaniline hydrochloride 0 0 0 0 0 0.000182 0.000182 C50471448 50471-44-8 Vinclozolin 0 1 0 0 0 0.000181 0.000181 C5598152 5598-15-2 Chlorpyrifos oxon 0 0 0 0 0 0.000174 0.000174 C552307 552-30-7 Trimellitic anhydride 0 0 0 0 0 0.000172 0.000172 C87865 87-86-5 Pentachlorophenol 0 1 1 0 0 0.000165 0.000165 C57976 57-97-6 7,12-Dimethylbenz(a)anthracene 0 0 0 0 0.000165 0 0.000165 C827190 827-19-0 Sodium 2,5-dimethylbenzenesulfonate 0 0 0 1 0.000157 0 0.000157 C102067 102-06-7 1,3-Diphenylguanidine 0 0 0 0 0 0.000156 0.000156 C71283802 71283-80-2 Fenoxaprop-P-ethyl 0 1 1 0 0 0.000153 0.000153 C20830755 20830-75-5 Digoxin 0 0 0 0 0 0.000148 0.000148 C68268 68-26-8 Retinol 0 0 0 0 0.000138 0 0.000138 C13301616 13301-61-6 C.I. Disperse Orange 37 0 0 0 0 0.000131 0 0.000131 C478263988 478263-98-8 AVE3295 0 0 0 0 0 0.00013 0.00013 C131860338 131860-33-8 Azoxystrobin 0 0 1 0 0.000129 5.13E-07 0.000129 C288880 288-88-0 1H-1,2,4-Triazole 0 0 0 0 0.000127 0 0.000127 C58846778 58846-77-8 Decyl beta-D-glucopyranoside 0 0 0 0 0.000123 0 0.000123 C78513 78-51-3 Tris(2-butoxyethyl) phosphate 0 0 0 0 0.000118 0 0.000118 C105512069 105512-06-9 Clodinafop-propargyl mixt. 0 0 1 0 0 0.000117 0.000117 C139968 139-96-8 Dodecyl sulfate triethanolamine 0 0 0 0 0.0000718 0.000116 0.000116 C88244 88-24-4 2,2'-Methylenebis(ethyl-6-tert-butylphenol) 0 0 0 0 0 0.000115 0.000115 C2312358 2312-35-8 Propargite 1 0 1 0 0 0.000113 0.000113 C88857 88-85-7 Dinoseb 0 0 0 0 0 0.000112 0.000112 C87674688 87674-68-8 Dimethenamid 0 0 1 0 0 0.000109 0.000109 C91532 91-53-2 Ethoxyquin 0 0 1 1 0.000107 0 0.000107 C4455269 4455-26-9 N-Methyldioctylamine 0 0 0 0 0.000107 0 0.000107 C112005 112-00-5 Dodecyltrimethylammonium chloride 0 0 0 1 0.000105 0 0.000105 C2310170 2310-17-0 Phosalone 0 0 0 0 0.000105 0 0.000105 C27253334 27253-33-4 Calcium neodecanoate 0 0 0 0 0.000105 0 0.000105 C107880 107-88-0 1,3-Butanediol 0 0 0 0 0.000104 0 0.000104 C309002 309-00-2 Aldrin 0 0 0 0 0.000104 0 0.000104 C334485 334-48-5 Decanoic acid 0 0 1 1 0.000102 0 0.000102 C72490018 72490-01-8 Fenoxycarb 0 0 0 0 0 0.000102 0.000102 C115957 115-95-7 Linalyl acetate 0 0 0 1 0 0.000101 0.000101 C344930956 344930-95-6 SSR69071 0 0 0 0 0.000101 0 0.000101 C43222486 43222-48-6 Difenzoquat metilsulfate 0 0 0 0 0.000101 0 0.000101 C13684565 13684-56-5 Desmedipham 0 0 1 0 0.0000996 0 0.0000996 C120068373 120068-37-3 Fipronil 0 0 1 0 0 0.0000943 0.0000943 C51218452 51218-45-2 Metolachlor 1 0 1 0 0.0000933 0 0.0000933

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 14**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C2353459 2353-45-9 FD&C Green No. 3 0 0 0 1 0 0.000092 0.000092 CNOCAS47325 NOCAS_47325 SB413217A 0 0 0 0 0.0000897 0 0.0000897 C100016 100-01-6 4-Nitroaniline 0 0 0 0 0 0.0000892 0.0000892 C533744 533-74-4 Dazomet 0 0 1 0 0 0.0000883 0.0000883 C2610119 2610-11-9 C.I. Direct Red 81 disodium salt 0 0 0 0 0 0.000085 0.000085 C1061517621 1061517-62-1 PharmaGSID_47337 0 0 0 0 0 0.0000824 0.0000824 C141662 141-66-2 Dicrotophos 0 1 1 0 0.0000797 0 0.0000797 C50657 50-65-7 Niclosamide 0 0 0 0 0 0.0000797 0.0000797 C2687969 2687-96-9 1-Dodecyl-2-pyrrolidinone 0 0 0 1 0 0.0000785 0.0000785 C298077 298-07-7 Bis(2-ethylhexyl) phosphate 0 0 0 0 0 0.0000785 0.0000785 C110235477 110235-47-7 Mepanipyrim 0 0 0 0 0.0000779 0 0.0000779 C75330755 75330-75-5 Lovastatin 0 0 0 0 0.0000755 0 0.0000755 C106934 106-93-4 1,2-Dibromoethane 0 0 0 0 0.0000737 0 0.0000737 C6706598 6706-59-8 L-Glucitol 0 0 0 0 0.0000722 0 0.0000722 C13171001 13171-00-1 1-(6-tert-Butyl-1,1-dimethyl-2,3-dihydro-1H-inden-4-yl)ethanone 0 0 0 1 0 0.0000715 0.0000715 C79902639 79902-63-9 Simvastatin 0 0 0 0 0.0000711 0 0.0000711 C42509808 42509-80-8 Isazofos 0 0 0 0 0.0000695 0 0.0000695 C82657043 82657-04-3 Bifenthrin 1 0 1 0 0.0000693 0 0.0000693 C112312 112-31-2 Decanal 0 0 0 1 0 0.0000655 0.0000655 C5598130 5598-13-0 Chlorpyrifos-methyl 0 0 1 0 0.0000635 0 0.0000635 C24157811 24157-81-1 2,6-Diisopropylnaphthalene 0 0 1 0 0.0000627 0 0.0000627 C7773060 7773-06-0 Ammonium sulfamate 0 0 0 0 0 0.0000625 0.0000625 CNOCAS47346 NOCAS_47346 SSR162369 0 0 0 0 0.0000623 0 0.0000623 C602017 602-01-7 2,3-Dinitrotoluene 0 0 0 0 0.0000613 0 0.0000613 C76578148 76578-14-8 Quizalofop-ethyl 0 0 1 0 0 0.000061 0.000061 C77930 77-93-0 Triethyl citrate 0 0 0 1 0.0000604 0 0.0000604 C40649363 40649-36-3 4-Propylcyclohexanone 0 0 0 0 0.000059 0 0.000059 C50226 50-22-6 Corticosterone 0 0 0 0 0.0000564 0 0.0000564 C8000348 8000-34-8 Clove leaf oil 0 0 0 1 0.0000549 0 0.0000549 C496720 496-72-0 3,4-Diaminotoluene 0 0 0 0 0.0000541 0 0.0000541 C122145 122-14-5 Fenitrothion 0 0 1 0 0.0000535 0 0.0000535 C113136779 113136-77-9 Cyclanilide 0 0 1 0 0 0.0000523 0.0000523 C88755 88-75-5 2-Nitrophenol 0 0 0 0 0 0.0000499 0.0000499 C35691657 35691-65-7 1,2-Dibromo-2,4-dicyanobutane 0 0 1 0 0 0.0000451 0.0000451 C60207901 60207-90-1 Propiconazole 1 0 1 0 0.0000437 0 0.0000437 C101053 101-05-3 Anilazine 0 0 0 0 0.0000431 0 0.0000431 C108838 108-83-8 Diisobutyl ketone 0 0 0 1 0 0.0000416 0.0000416 CNOCAS47374 NOCAS_47374 SSR161421 0 0 0 0 0.00000598 0.0000394 0.0000394 C78488 78-48-8 Tribufos 0 0 1 0 0.0000383 0 0.0000383 C88584 88-58-4 2,5-Di-tert-butylbenzene-1,4-diol 0 0 0 0 0 0.0000343 0.0000343

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 15**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C1897456 1897-45-6 Chlorothalonil 1 0 1 0 0 0.0000273 0.0000273 C1689845 1689-84-5 Bromoxynil 0 0 1 0 0 0.0000271 0.0000271 C186392654 186392-65-4 Ingliforib 0 0 0 0 0 0.0000263 0.0000263 C121391 121-39-1 Ethyl 3-phenylglycidate 0 0 0 1 0 0.0000239 0.0000239 C103117 103-11-7 2-Ethylhexyl acrylate 0 0 0 0 0 0.0000216 0.0000216 CNOCAS47708 NOCAS_47708 Igepal CO-890 0 0 0 0 0 0.000021 0.000021 C49562289 49562-28-9 Fenofibrate 0 0 0 0 0.0000209 0 0.0000209 C1156190 1156-19-0 Tolazamide 0 0 0 0 0.0000167 0 0.0000167 C147819 147-81-9 Arabinose 0 0 0 0 0 0.0000159 0.0000159 C335762 335-76-2 PFDA 0 0 0 0 0.0000142 0 0.0000142 C138227 138-22-7 Butyl lactate 0 0 0 1 0 0.0000109 0.0000109 C35554440 35554-44-0 Imazalil 0 0 1 0 0.00000832 0.00000736 0.00000832 C196808454 196808-45-4 Farglitazar 0 0 0 0 0 0.00000761 0.00000761 C120650 120-65-0 2-((Dimethylamino)methyl)phenol 0 0 0 0 0.00000752 0 0.00000752 C118558 118-55-8 Phenyl salicylate 0 0 0 0 0 0.00000579 0.00000579 C106230 106-23-0 Citronellal 0 0 0 1 0 0.00000484 0.00000484 C112801 112-80-1 Oleic acid 0 0 0 1 0 0.00000405 0.00000405 C139026 139-02-6 Sodium phenolate 0 0 1 0 0 0.00000345 0.00000345 C115775 115-77-5 Pentaerythritol 0 0 0 0 0 0.00000177 0.00000177 C67209 67-20-9 Nitrofurantoin 0 0 0 0 0.00000137 0 0.00000137 CNOCAS47311 NOCAS_47311 GSK163929B 0 0 0 0 0 6.09E-07 6.09E-07 C111400 111-40-0 Diethylenetriamine 0 0 0 0 0 6.03E-07 6.03E-07 C101371 101-37-1 2,4,6-Tris(allyloxy)-1,3,5-triazine 0 0 0 0 0 5.89E-07 5.89E-07 C219790724 219790-72-4 SB281832 0 0 0 0 0 4.35E-07 4.35E-07 C90823384 90823-38-4 Denatonium saccharide 0 1 1 0 0 4.01E-07 4.01E-07 C79947 79-94-7 3,3',5,5'-Tetrabromobisphenol A 0 0 0 0 0 3.81E-07 3.81E-07 C66441234 66441-23-4 Fenoxaprop-ethyl 0 0 0 0 0 2.96E-07 2.96E-07 C120514 120-51-4 Benzyl benzoate 0 0 1 1 0 2.89E-07 2.89E-07 C15299997 15299-99-7 Napropamide 0 0 1 0 0 2.68E-07 2.68E-07 C34256821 34256-82-1 Acetochlor 0 1 1 0 0 2.67E-07 2.67E-07 C15307796 15307-79-6 Diclofenac sodium 0 0 0 0 0 2.58E-07 2.58E-07 C133073 133-07-3 Folpet 1 0 1 0 0 2.33E-07 2.33E-07 C26447109 26447-10-9 Ammonium xylene sulfonate 0 0 0 1 0 2.31E-07 2.31E-07 C25550985 25550-98-5 Diisodecylphenyl phosphite 0 0 0 0 0 0.00000021 0.00000021 C106478 106-47-8 4-Chloroaniline 0 0 0 0 0 1.73E-07 1.73E-07 C120923 120-92-3 Cyclopentanone 0 0 0 0 0 1.66E-07 1.66E-07 C361377299 361377-29-9 Fluoxastrobin 0 0 1 0 0 0.00000016 0.00000016 C98967409 98967-40-9 Flumetsulam 0 1 1 0 0 1.44E-07 1.44E-07 C90948 90-94-8 Michler's ketone 0 0 0 0 0 1.41E-07 1.41E-07 C28434006 28434-00-6 S-Bioallethrin 0 0 1 0 0 0.00000013 0.00000013

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 16**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C19774824 19774-82-4 Amiodarone hydrochloride 0 0 0 0 0 0.00000011 0.00000011 C94097 94-09-7 Benzocaine 0 0 0 0 0 9.69E-08 9.69E-08 C291305061 291305-06-1 UK-373911 0 0 0 0 0 6.68E-08 6.68E-08 C1323382 1323-38-2 Glyceryl monoricinoleate 0 0 0 0 0 4.01E-08 4.01E-08 C1929777 1929-77-7 Vernolate 0 0 0 0 0 9.7E-09 9.7E-09 C584134 584-13-4 4-Amino-1,2,4-triazole 0 0 0 0 7.51E-09 0 7.51E-09 C87241 87-24-1 Ethyl 2-methylbenzoate 0 0 0 0 0 2.85E-10 2.85E-10 C117806 117-80-6 Dichlone 0 0 0 0 0 1.96E-20 1.96E-20 C155569918 155569-91-8 Emamectin benzoate 0 0 1 0 0 5.68E-21 5.68E-21 C86479063 86479-06-3 Hexaflumuron 0 0 1 0 1.42E-21 0 1.42E-21 C10265926 10265-92-6 Methamidophos 1* 0 0 0 0 0 0 C117817 117-81-7 Di(2-ethylhexyl) phthalate 1* 0 0 0 0 0 0 C131113 131-11-3 Dimethyl phthalate 1* 0 0 0 0 0 0 C298000 298-00-0 Methyl parathion 1* 0 0 0 0 0 0 C84662 84-66-2 Diethyl phthalate 1* 0 0 0 0 0 0 C950378 950-37-8 Methidathion 1* 0 0 0 0 0 0 C107534963 107534-96-3 Tebuconazole 1 0 1 0 0 0 0 C113484 113-48-4 MGK-264 1 0 1 0 0 0 0 C1194656 1194-65-6 Dichlobenil 1 0 1 0 0 0 0 C121755 121-75-5 Malathion 1 0 1 0 0 0 0 C122349 122-34-9 Simazine 1 0 1 0 0 0 0 C13194484 13194-48-4 Ethoprop 1 0 1 0 0 0 0 C133062 133-06-2 Captan 1 0 1 0 0 0 0 C138261413 138261-41-3 Imidacloprid 1 0 1 0 0 0 0 C1563662 1563-66-2 Carbofuran 1 0 1 0 0 0 0 C16752775 16752-77-5 Methomyl 1 0 1 0 0 0 0 C1861321 1861-32-1 Chlorthal-dimethyl 1 0 1 0 0 0 0 C1912249 1912-24-9 Atrazine 1 0 1 0 0 0 0 C21087649 21087-64-9 Metribuzin 1 0 1 0 0 0 0 C22248799 22248-79-9 Z-Tetrachlorvinphos 1 0 1 0 0 0 0 C23135220 23135-22-0 Oxamyl 1 0 1 0 0 0 0 C23950585 23950-58-5 Propyzamide 1 0 1 0 0 0 0 C27314132 27314-13-2 Norflurazon 1 0 1 0 0 0 0 C30560191 30560-19-1 Acephate 1 0 1 0 0 0 0 C330552 330-55-2 Linuron 1 0 1 0 0 0 0 C36734197 36734-19-7 Iprodione 1 0 1 0 0 0 0 C52645531 52645-53-1 Permethrin 1 0 1 0 0 0 0 C57837191 57837-19-1 Metalaxyl 1 0 1 0 0 0 0 C60515 60-51-5 Dimethoate 1 0 1 0 0 0 0 C66230044 66230-04-4 Esfenvalerate 1 0 1 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 17**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C66332965 66332-96-5 Flutolanil 1 0 1 0 0 0 0 C68359375 68359-37-5 Cyfluthrin 1 0 1 0 0 0 0 C732116 732-11-6 Phosmet 1 0 1 0 0 0 0 C759944 759-94-4 EPTC 1 0 1 0 0 0 0 C88671890 88671-89-0 My clobutanil 1 0 1 0 0 0 0 C94757 94-75-7 2,4-Dichlorophenoxyacetic acid 1 0 1 0 0 0 0 C78591 78-59-1 Isophorone 1 0 0 1 0 0 0 C106467 106-46-7 1,4-Dichlorobenzene 0 1 1 0 0 0 0 C145733 145-73-3 Endothal 0 1 1 0 0 0 0 C15972608 15972-60-8 Alachlor 0 1 1 0 0 0 0 C1918021 1918-02-1 Picloram 0 1 1 0 0 0 0 C23564058 23564-05-8 Thiophanate-methyl 0 1 1 0 0 0 0 C330541 330-54-1 Diuron 0 1 1 0 0 0 0 C420042 420-04-2 Cyanamide 0 1 1 0 0 0 0 C42874033 42874-03-3 Oxy fluorfen 0 1 1 0 0 0 0 C56724 56-72-4 Coumaphos 0 1 1 0 0 0 0 C66215278 66215-27-8 Cyromazine 0 1 1 0 0 0 0 C68694111 68694-11-1 Triflumizole 0 1 1 0 0 0 0 C74115245 74115-24-5 Clofentezine 0 1 1 0 0 0 0 C76738620 76738-62-0 Paclobutrazol 0 1 1 0 0 0 0 C77501634 77501-63-4 Lactofen 0 1 1 0 0 0 0 C78587050 78587-05-0 Hexythiazox 0 1 1 0 0 0 0 C80844071 80844-07-1 Etofenprox 0 1 1 0 0 0 0 C81777891 81777-89-1 Clomazone 0 1 1 0 0 0 0 C82558507 82558-50-7 Isoxaben 0 1 1 0 0 0 0 C84087014 84087-01-4 Quinclorac 0 1 1 0 0 0 0 C95266403 95266-40-3 Trinexapac-ethyl 0 1 1 0 0 0 0 C107211 107-21-1 Ethylene glycol 0 1 0 1 0 0 0 C872504 872-50-4 N-Methyl-2-pyrrolidone 0 1 0 1 0 0 0 C103231 103-23-1 Di(2-ethylhexyl) adipate 0 1 0 0 0 0 0 C103651 103-65-1 Propylbenzene 0 1 0 0 0 0 0 C107186 107-18-6 Allyl alcohol 0 1 0 0 0 0 0 C109864 109-86-4 2-Methoxyethanol 0 1 0 0 0 0 0 C114078 114-07-8 Erythromycin 0 1 0 0 0 0 0 C120821 120-82-1 1,2,4-Trichlorobenzene 0 1 0 0 0 0 0 C156605 156-60-5 (E)-1,2-Dichloroethylene 0 1 0 0 0 0 0 C335671 335-67-1 PFOA 0 1 0 0 0 0 0 C60355 60-35-5 Acetamide 0 1 0 0 0 0 0 C62759 62-75-9 N-Nitrosodimethylamine 0 1 0 0 0 0 0 C79061 79-06-1 Acrylamide 0 1 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 18**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C91225 91-22-5 Quinoline 0 1 0 0 0 0 0 C95534 95-53-4 2-Methylaniline 0 1 0 0 0 0 0 C96184 96-18-4 1,2,3-Trichloropropane 0 1 0 0 0 0 0 C96457 96-45-7 Ethylene thiourea 0 1 0 0 0 0 0 C98953 98-95-3 Nitrobenzene 0 1 0 0 0 0 0 C99650 99-65-0 1,3-Dinitrobenzene 0 1 0 0 0 0 0 C10043353 10043-35-3 Boric acid 0 0 1 1 0 0 0 C105679 105-67-9 2,4-Dimethylphenol 0 0 1 1 0 0 0 C106229 106-22-9 Citronellol 0 0 1 1 0 0 0 C106241 106-24-1 Geraniol 0 0 1 1 0 0 0 C108394 108-39-4 m-Cresol 0 0 1 1 0 0 0 C108952 108-95-2 Phenol 0 0 1 1 0 0 0 C110270 110-27-0 Isopropyl tetradecanoic acid 0 0 1 1 0 0 0 C1111780 1111-78-0 Ammonium carbamate 0 0 1 1 0 0 0 C111773 111-77-3 Diethylene glycol monomethyl ether 0 0 1 1 0 0 0 C111875 111-87-5 1-Octanol 0 0 1 1 0 0 0 C112050 112-05-0 Nonanoic acid 0 0 1 1 0 0 0 C112276 112-27-6 Triethylene glycol 0 0 1 1 0 0 0 C112301 112-30-1 1-Decanol 0 0 1 1 0 0 0 C112389 112-38-9 10-Undecenoic acid 0 0 1 1 0 0 0 C112538 112-53-8 1-Dodecanol 0 0 1 1 0 0 0 C119368 119-36-8 Methyl salicylate 0 0 1 1 0 0 0 C120729 120-72-9 Indole 0 0 1 1 0 0 0 C127413 127-41-3 alpha-Ionone 0 0 1 1 0 0 0 C134203 134-20-3 Methyl 2-aminobenzoate 0 0 1 1 0 0 0 C1490046 1490-04-6 Menthol 0 0 1 1 0 0 0 C151213 151-21-3 Sodium dodecyl sulfate 0 0 1 1 0 0 0 C1934210 1934-21-0 FD&C Yellow 5 0 0 1 1 0 0 0 C25265718 25265-71-8 Dipropylene glycol 0 0 1 1 0 0 0 C26172554 26172-55-4 5-Chloro-2-methyl-3(2H)-isothiazolone 0 0 1 1 0 0 0 C2634335 2634-33-5 1,2-Benzisothiazolin-3-one 0 0 1 1 0 0 0 C26402266 26402-26-6 Glyceryl monooctanoate 0 0 1 1 0 0 0 C2893789 2893-78-9 Sodium dichloroisocyanurate 0 0 1 1 0 0 0 C3391864 3391-86-4 1-Octen-3-ol 0 0 1 1 0 0 0 C52517 52-51-7 Bronopol 0 0 1 1 0 0 0 C5392405 5392-40-5 3,7-Dimethyl-2,6-octadienal 0 0 1 1 0 0 0 C56815 56-81-5 Glycerol 0 0 1 1 0 0 0 C57136 57-13-6 Urea 0 0 1 1 0 0 0 C57501 57-50-1 Sucrose 0 0 1 1 0 0 0 C57556 57-55-6 1,2-Propylene glycol 0 0 1 1 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 19**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C577117 577-11-7 Docusate sodium 0 0 1 1 0 0 0 C65850 65-85-0 Benzoic acid 0 0 1 1 0 0 0 C68917180 68917-18-0 Cornmint oil 0 0 1 1 0 0 0 C7212444 7212-44-4 Nerolidol 0 0 1 1 0 0 0 C77065 77-06-5 Gibberellic acid 0 0 1 1 0 0 0 C77929 77-92-9 Citric acid 0 0 1 1 0 0 0 C78706 78-70-6 Linalool 0 0 1 1 0 0 0 C91203 91-20-3 Naphthalene 0 0 1 1 0 0 0 C93152 93-15-2 Methyleugenol 0 0 1 1 0 0 0 C97530 97-53-0 Eugenol 0 0 1 1 0 0 0 C98011 98-01-1 Furfural 0 0 1 1 0 0 0 C101213 101-21-3 Chlorpropham 0 0 1 0 0 0 0 C10222012 10222-01-2 2,2-Dibromo-3-nitrilopropionamide 0 0 1 0 0 0 0 C103055078 103055-07-8 Lufenuron 0 0 1 0 0 0 0 C103361097 103361-09-7 Flumioxazin 0 0 1 0 0 0 0 C103902 103-90-2 Acetaminophen 0 0 1 0 0 0 0 C104098488 104098-48-8 Imazapic 0 0 1 0 0 0 0 C104206828 104206-82-8 Mesotrione 0 0 1 0 0 0 0 C10605217 10605-21-7 Carbendazim 0 0 1 0 0 0 0 C110488705 110488-70-5 Dimethomorph 0 0 1 0 0 0 0 C111308 111-30-8 Glutaraldehyde 0 0 1 0 0 0 0 C111991094 111991-09-4 Nicosulfuron 0 0 1 0 0 0 0 C112410238 112410-23-8 Tebufenozide 0 0 1 0 0 0 0 C112721 112-72-1 1-Tetradecanol 0 0 1 0 0 0 0 C1134232 1134-23-2 Cycloate 0 0 1 0 0 0 0 C114261 114-26-1 Propoxur 0 0 1 0 0 0 0 C114311329 114311-32-9 Imazamox 0 0 1 0 0 0 0 C116063 116-06-3 Aldicarb 0 0 1 0 0 0 0 C116255482 116255-48-2 Bromuconazole 0 0 1 0 0 0 0 C116714466 116714-46-6 Novaluron 0 0 1 0 0 0 0 C117337196 117337-19-6 Fluthiacet-methyl 0 0 1 0 0 0 0 C118525 118-52-5 1,3-Dichloro-5,5-dimethylhydantoin 0 0 1 0 0 0 0 C119515387 119515-38-7 Icaridin 0 0 1 0 0 0 0 C120116883 120116-88-3 Cyazofamid 0 0 1 0 0 0 0 C1214397 1214-39-7 N-Benzyladenine 0 0 1 0 0 0 0 C122008859 122008-85-9 Cyhalofop-butyl 0 0 1 0 0 0 0 C122836355 122836-35-5 Sulfentrazone 0 0 1 0 0 0 0 C122883 122-88-3 4-Chlorophenoxyacetic acid 0 0 1 0 0 0 0 C123312890 123312-89-0 Pymetrozine 0 0 1 0 0 0 0 C123331 123-33-1 Maleic hydrazide 0 0 1 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 20**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C123343168 123343-16-8 Pyrithiobac-sodium 0 0 1 0 0 0 0 C124495187 124495-18-7 Quinoxyfen 0 0 1 0 0 0 0 C125401925 125401-92-5 Bispyribac-sodium 0 0 1 0 0 0 0 C126067 126-06-7 3-Bromo-1-chloro-5,5-dimethylhydantoin 0 0 1 0 0 0 0 C126114 126-11-4 2-(Hydroxymethyl)-2-nitro-1,3-propanediol 0 0 1 0 0 0 0 C128041 128-04-1 Sodium dimethyldithiocarbamate 0 0 1 0 0 0 0 C128639021 128639-02-1 Carfentrazone-ethyl 0 0 1 0 0 0 0 C129630199 129630-19-9 Pyraflufen-ethyl 0 0 1 0 0 0 0 C131983727 131983-72-7 Triticonazole 0 0 1 0 0 0 0 C134623 134-62-3 DEET 0 0 1 0 0 0 0 C135158542 135158-54-2 Acibenzolar-S-methyl 0 0 1 0 0 0 0 C135410207 135410-20-7 Acetamiprid 0 0 1 0 0 0 0 C136458 136-45-8 Dipropyl pyridine-2,5-dicarboxylate 0 0 1 0 0 0 0 C13684634 13684-63-4 Phenmedipham 0 0 1 0 0 0 0 C137428 137-42-8 Metam-sodium 0 0 1 0 0 0 0 C139402 139-40-2 Propazine 0 0 1 0 0 0 0 C141112290 141112-29-0 Isoxaflutole 0 0 1 0 0 0 0 C141517217 141517-21-7 Trifloxystrobin 0 0 1 0 0 0 0 C142459583 142459-58-3 Flufenacet 0 0 1 0 0 0 0 C144550367 144550-36-7 Iodosulfuron-methyl-sodium 0 0 1 0 0 0 0 C145701219 145701-21-9 Diclosulam 0 0 1 0 0 0 0 C148477718 148477-71-8 Spirodiclofen 0 0 1 0 0 0 0 C148798 148-79-8 Thiabendazole 0 0 1 0 0 0 0 C149877418 149877-41-8 Bifenazate 0 0 1 0 0 0 0 C153233911 153233-91-1 Etoxazole 0 0 1 0 0 0 0 C153719234 153719-23-4 Thiamethoxam 0 0 1 0 0 0 0 C15708415 15708-41-5 Ethylenediaminetetraacetic acid ferric sodium salt 0 0 1 0 0 0 0 C16079882 16079-88-2 Bromo-3-chloro-5,5-dimethylhydantoin 0 0 1 0 0 0 0 C1610180 1610-18-0 Prometon 0 0 1 0 0 0 0 C161050584 161050-58-4 Methoxyfenozide 0 0 1 0 0 0 0 C165252700 165252-70-0 Dinotefuran 0 0 1 0 0 0 0 C16672870 16672-87-0 Ethephon 0 0 1 0 0 0 0 C1698608 1698-60-8 Chloridazon 0 0 1 0 0 0 0 C1702176 1702-17-6 Clopyralid 0 0 1 0 0 0 0 C173584446 173584-44-6 Indoxacarb 0 0 1 0 0 0 0 C181274157 181274-15-7 Propoxycarbazone-sodium 0 0 1 0 0 0 0 C181274179 181274-17-9 Flucarbazone-sodium 0 0 1 0 0 0 0 C188425856 188425-85-6 Boscalid 0 0 1 0 0 0 0 C188489078 188489-07-8 Flufenpyr-ethyl 0 0 1 0 0 0 0 C19044883 19044-88-3 Ory zalin 0 0 1 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 21**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C1918009 1918-00-9 Dicamba 0 0 1 0 0 0 0 C1929733 1929-73-3 2,4-D-Butotyl 0 0 1 0 0 0 0 C1929824 1929-82-4 Nitrapyrin 0 0 1 0 0 0 0 C19666309 19666-30-9 Oxadiazon 0 0 1 0 0 0 0 C2058460 2058-46-0 Oxy tetracycline hydrochloride 0 0 1 0 0 0 0 C210631688 210631-68-8 Topramezone 0 0 1 0 0 0 0 C210880925 210880-92-5 Clothianidin 0 0 1 0 0 0 0 C2122705 2122-70-5 Ethyl 1-naphthaleneacetate 0 0 1 0 0 0 0 C21564170 21564-17-0 2-(Thiocyanomethylthio)benzothiazole 0 0 1 0 0 0 0 C2164172 2164-17-2 Fluometuron 0 0 1 0 0 0 0 C219714962 219714-96-2 Penoxsulam 0 0 1 0 0 0 0 C23031369 23031-36-9 Prallethrin 0 0 1 0 0 0 0 C2303175 2303-17-5 Tri-allate 0 0 1 0 0 0 0 C23422539 23422-53-9 Formetanate hydrochloride 0 0 1 0 0 0 0 C24307264 24307-26-4 Mepiquat chloride 0 0 1 0 0 0 0 C25057890 25057-89-0 Bentazone 0 0 1 0 0 0 0 C25606411 25606-41-1 Propamocarb hydrochloride 0 0 1 0 0 0 0 C2593159 2593-15-9 Etridiazole 0 0 1 0 0 0 0 C26002802 26002-80-2 Phenothrin 0 0 1 0 0 0 0 C26530201 26530-20-1 Octhilinone 0 0 1 0 0 0 0 C26644462 26644-46-2 Triforine 0 0 1 0 0 0 0 C2702729 2702-72-9 2,4-D sodium salt 0 0 1 0 0 0 0 C2782572 2782-57-2 Troclosene 0 0 1 0 0 0 0 C28159980 28159-98-0 Cybutryne 0 0 1 0 0 0 0 C28249776 28249-77-6 Thiobencarb 0 0 1 0 0 0 0 C283594901 283594-90-1 Spiromesifen 0 0 1 0 0 0 0 C300765 300-76-5 Naled 0 0 1 0 0 0 0 C314409 314-40-9 Bromacil 0 0 1 0 0 0 0 C33089611 33089-61-1 Amitraz 0 0 1 0 0 0 0 C3380345 3380-34-5 Triclosan 0 0 1 0 0 0 0 C33956499 33956-49-9 Codlelure 0 0 1 0 0 0 0 C34014181 34014-18-1 Tebuthiuron 0 0 1 0 0 0 0 C35367385 35367-38-5 Diflubenzuron 0 0 1 0 0 0 0 C3653483 3653-48-3 MCPA-sodium 0 0 1 0 0 0 0 C51235042 51235-04-2 Hexazinone 0 0 1 0 0 0 0 C51338273 51338-27-3 Diclofop-methyl 0 0 1 0 0 0 0 C51580860 51580-86-0 Sodium dichloro-s-triazinetrione dihydrate 0 0 1 0 0 0 0 C51707552 51707-55-2 Thidiazuron 0 0 1 0 0 0 0 C5234684 5234-68-4 Carboxin 0 0 1 0 0 0 0 C525791 525-79-1 Kinetin 0 0 1 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 22**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C52918635 52918-63-5 Deltamethrin 0 0 1 0 0 0 0 C53112280 53112-28-0 Pyrimethanil 0 0 1 0 0 0 0 C55335063 55335-06-3 Triclopyr 0 0 1 0 0 0 0 C556616 556-61-6 Methyl isothiocyanate 0 0 1 0 0 0 0 C57067 57-06-7 Allyl isothiocyanate 0 0 1 0 0 0 0 C571584 571-58-4 1,4-Dimethylnaphthalene 0 0 1 0 0 0 0 C57754855 57754-85-5 Clopyralid-olamine 0 0 1 0 0 0 0 C57966957 57966-95-7 Cymoxanil 0 0 1 0 0 0 0 C584792 584-79-2 Allethrin 0 0 1 0 0 0 0 C5870939 5870-93-9 Heptyl butanoate 0 0 1 0 0 0 0 C5902512 5902-51-2 Terbacil 0 0 1 0 0 0 0 C59669260 59669-26-0 Thiodicarb 0 0 1 0 0 0 0 C59756604 59756-60-4 Fluridone 0 0 1 0 0 0 0 C62737 62-73-7 Dichlorvos 0 0 1 0 0 0 0 C62748 62-74-8 Sodium fluoroacetate 0 0 1 0 0 0 0 C6317186 6317-18-6 Methylene bis(thiocyanate) 0 0 1 0 0 0 0 C64700567 64700-56-7 Triclopyr-butotyl 0 0 1 0 0 0 0 C67564914 67564-91-4 (2R,6S)-Fenpropimorph 0 0 1 0 0 0 0 C68157608 68157-60-8 Forchlorfenuron 0 0 1 0 0 0 0 C69377817 69377-81-7 Fluroxypyr 0 0 1 0 0 0 0 C69727 69-72-7 Salicylic acid 0 0 1 0 0 0 0 C709988 709-98-8 Propanil 0 0 1 0 0 0 0 C72178020 72178-02-0 Fomesafen 0 0 1 0 0 0 0 C7287196 7287-19-6 Prometryn 0 0 1 0 0 0 0 C74051802 74051-80-2 Sethoxydim 0 0 1 0 0 0 0 C75503 75-50-3 Trimethylamine 0 0 1 0 0 0 0 C7696120 7696-12-0 Tetramethrin 0 0 1 0 0 0 0 C77485 77-48-5 1,3-Dibromo-5,5-dimethylhydantoin 0 0 1 0 0 0 0 C7757791 7757-79-1 Potassium nitrate 0 0 1 0 0 0 0 C79141 79-14-1 Glycolic acid 0 0 1 0 0 0 0 C79277273 79277-27-3 Thifensulfuron-methyl 0 0 1 0 0 0 0 C79538322 79538-32-2 Tefluthrin 0 0 1 0 0 0 0 C8018017 8018-01-7 Mancozeb 0 0 1 0 0 0 0 C81334341 81334-34-1 Imazapyr 0 0 1 0 0 0 0 C81335377 81335-37-7 Imazaquin 0 0 1 0 0 0 0 C81335775 81335-77-5 Imazethapyr 0 0 1 0 0 0 0 C81812 81-81-2 Wa rfarin 0 0 1 0 0 0 0 C824395 824-39-5 Sodium 2-nitrophenolate 0 0 1 0 0 0 0 C824782 824-78-2 Sodium 4-nitrophenolate 0 0 1 0 0 0 0 C828002 828-00-2 Dimethoxane 0 0 1 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 23**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C834128 834-12-8 Ametryn 0 0 1 0 0 0 0 C85264331 85264-33-1 (3,5-Dimethyl-1H-pyrazol-1-yl)methanol 0 0 1 0 0 0 0 C86873 86-87-3 1-Naphthaleneacetic acid 0 0 1 0 0 0 0 C87392129 87392-12-9 S-Metolachlor 0 0 1 0 0 0 0 C87546187 87546-18-7 Flumiclorac-pentyl 0 0 1 0 0 0 0 C87901 87-90-1 Symclosene 0 0 1 0 0 0 0 C91465086 91465-08-6 lambda-Cyhalothrin 0 0 1 0 0 0 0 C93652 93-65-2 Mecoprop 0 0 1 0 0 0 0 C94746 94-74-6 MCPA 0 0 1 0 0 0 0 C94815 94-81-5 MCPB 0 0 1 0 0 0 0 C94826 94-82-6 2,4-DB 0 0 1 0 0 0 0 C95761 95-76-1 3,4-Dichloroaniline 0 0 1 0 0 0 0 C96182535 96182-53-5 Tebupirimfos 0 0 1 0 0 0 0 C96242 96-24-2 3-Chloro-1,2-propanediol 0 0 1 0 0 0 0 C98886443 98886-44-3 Fosthiazate 0 0 1 0 0 0 0 C99309 99-30-9 Dicloran 0 0 1 0 0 0 0 C10025748 10025-74-8 Dysprosium(III) chloride 0 0 0 1 0 0 0 C100516 100-51-6 Benzyl alcohol 0 0 0 1 0 0 0 C10094345 10094-34-5 1,1-Dimethyl-2-phenylethyl butanoate 0 0 0 1 0 0 0 C100970 100-97-0 Methenamine 0 0 0 1 0 0 0 C101848 101-84-8 Diphenyl oxide 0 0 0 1 0 0 0 C102603 102-60-3 N,N,N',N'-Tetrakis(2-Hydroxypropyl)ethylenediamine 0 0 0 1 0 0 0 C102716 102-71-6 Triethanolamine 0 0 0 1 0 0 0 C103413 103-41-3 Benzyl cinnamate 0 0 0 1 0 0 0 C104450 104-45-0 4-Propylanisole 0 0 0 1 0 0 0 C104610 104-61-0 gamma-Nonanolactone 0 0 0 1 0 0 0 C104676 104-67-6 5-Heptyldihydro-2(3H)-furanone 0 0 0 1 0 0 0 C104767 104-76-7 2-Ethyl-1-hexanol 0 0 0 1 0 0 0 C105215 105-21-5 1,4-Heptanolide 0 0 0 1 0 0 0 C105373 105-37-3 Ethyl propionate 0 0 0 1 0 0 0 C105544 105-54-4 Ethyl butyrate 0 0 0 1 0 0 0 C105873 105-87-3 Geranyl acetate 0 0 0 1 0 0 0 C106252 106-25-2 (2Z)-3,7-Dimethylocta-2,6-dien-1-ol 0 0 0 1 0 0 0 C106274 106-27-4 Isopentyl butyrate 0 0 0 1 0 0 0 C106445 106-44-5 p-Cresol 0 0 0 1 0 0 0 C106650 106-65-0 Dimethyl succinate 0 0 0 1 0 0 0 C106683 106-68-3 3-Octanone 0 0 0 1 0 0 0 C107415 107-41-5 2-Methyl-2,4-pentanediol 0 0 0 1 0 0 0 C107540 107-54-0 3,5-Dimethyl-1-hexyn-3-ol 0 0 0 1 0 0 0 C107755 107-75-5 7-Hydroxy-3,7-dimethyloctanal 0 0 0 1 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 24**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C107926 107-92-6 Butanoic acid 0 0 0 1 0 0 0 C108327 108-32-7 Propylene carbonate 0 0 0 1 0 0 0 C108419336 108419-33-6 Acetic acid, C8-10-branched alkyl esters, C9-rich 0 0 0 1 0 0 0 C108678 108-67-8 1,3,5-Trimethylbenzene 0 0 0 1 0 0 0 C108689 108-68-9 3,5-Dimethylphenol 0 0 0 1 0 0 0 C108941 108-94-1 Cyclohexanone 0 0 0 1 0 0 0 C109524 109-52-4 Pentanoic acid 0 0 0 1 0 0 0 C110167 110-16-7 Maleic acid 0 0 0 1 0 0 0 C110178 110-17-8 Fumaric acid 0 0 0 1 0 0 0 C110429 110-42-9 Methyl decanoate 0 0 0 1 0 0 0 C110430 110-43-0 2-Heptanone 0 0 0 1 0 0 0 C110441 110-44-1 Sorbic acid 0 0 0 1 0 0 0 C110623 110-62-3 Pentanal 0 0 0 1 0 0 0 C11099073 11099-07-3 Glyceryl stearates 0 0 0 1 0 0 0 C111115 111-11-5 Methyl octanoate 0 0 0 1 0 0 0 C111148 111-14-8 Heptanoic acid 0 0 0 1 0 0 0 C111273 111-27-3 1-Hexanol 0 0 0 1 0 0 0 C111422 111-42-2 Diethanolamine 0 0 0 1 0 0 0 C111466 111-46-6 Diethylene glycol 0 0 0 1 0 0 0 C111626 111-62-6 Ethyl oleate 0 0 0 1 0 0 0 C111706 111-70-6 1-Heptanol 0 0 0 1 0 0 0 C111762 111-76-2 2-Butoxyethanol 0 0 0 1 0 0 0 C111820 111-82-0 Methyl dodecanoate 0 0 0 1 0 0 0 C1118929 1118-92-9 N,N-Dimethyloctanamide 0 0 0 1 0 0 0 C111900 111-90-0 2-(2-Ethoxyethoxy)ethanol 0 0 0 1 0 0 0 C1119400 1119-40-0 Dimethyl glutarate 0 0 0 1 0 0 0 C1120214 1120-21-4 Undecane 0 0 0 1 0 0 0 C112141 112-14-1 Octy l acetate 0 0 0 1 0 0 0 C112345 112-34-5 2-(2-Butoxyethoxy)ethanol 0 0 0 1 0 0 0 C112425 112-42-5 1-Undecanol 0 0 0 1 0 0 0 C112630 112-63-0 Methyl linoleate 0 0 0 1 0 0 0 C116029 116-02-9 3,3,5-Trimethylcyclohexanol 0 0 0 1 0 0 0 C118718 118-71-8 Maltol 0 0 0 1 0 0 0 C118821 118-82-1 4,4'-Methylenebis(2,6-di-t-butylphenol) 0 0 0 1 0 0 0 C1191500 1191-50-0 Sodium myristyl sulfate 0 0 0 1 0 0 0 C121324 121-32-4 3-Ethoxy-4-hydroxybenzaldehyde 0 0 0 1 0 0 0 C121335 121-33-5 4-Hydroxy-3-methoxybenzaldehyde 0 0 0 1 0 0 0 C122203 122-20-3 Triisopropanolamine 0 0 0 1 0 0 0 C122996 122-99-6 2-Phenoxyethanol 0 0 0 1 0 0 0 C123115 123-11-5 4-Methoxybenzaldehyde 0 0 0 1 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 25**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C123353 123-35-3 My rcene 0 0 0 1 0 0 0 C123660 123-66-0 Ethyl hexanoate 0 0 0 1 0 0 0 C123922 123-92-2 3-Methylbutyl acetate 0 0 0 1 0 0 0 C124130 124-13-0 Octanal 0 0 0 1 0 0 0 C124185 124-18-5 Decane 0 0 0 1 0 0 0 C124196 124-19-6 Nonanal 0 0 0 1 0 0 0 C124765 124-76-5 Isoborneol 0 0 0 1 0 0 0 C125122 125-12-2 Isobornyl acetate 0 0 0 1 0 0 0 C126147 126-14-7 Sucrose octaacetate 0 0 0 1 0 0 0 C126863 126-86-3 2,4,7,9-Tetramethyl-5-decyne-4,7-diol 0 0 0 1 0 0 0 C126921 126-92-1 Sodium ethasulfate 0 0 0 1 0 0 0 C127399 127-39-9 Sodium 1,4-diisobutyl sulfosuccinate 0 0 0 1 0 0 0 C128370 128-37-0 Butylated hydroxytoluene 0 0 0 1 0 0 0 C128392 128-39-2 2,6-Di-tert-butylphenol 0 0 0 1 0 0 0 C1300727 1300-72-7 Sodium xylenesulfonate 0 0 0 1 0 0 0 C1323199 1323-19-9 Sodium 2,4,7-tri(propan-2-yl)naphthalene-1-sulfonate 0 0 0 1 0 0 0 C13254347 13254-34-7 2,6-Dimethyl-2-heptanol 0 0 0 1 0 0 0 C1335462 1335-46-2 Ionone, methyl- 0 0 0 1 0 0 0 C1338438 1338-43-8 Sorbitan, mono-(9Z)-9-octadecenoate 0 0 0 1 0 0 0 C137666 137-66-6 Ascorbyl palmitate 0 0 0 1 0 0 0 C138863 138-86-3 Limonene 0 0 0 1 0 0 0 C139888 139-88-8 7-Ethyl-2-methyl-4-undecanolsulfate, sodium salt 0 0 0 1 0 0 0 C140114 140-11-4 Benzyl acetate 0 0 0 1 0 0 0 C1401554 1401-55-4 Tannic acid 0 0 0 1 0 0 0 C142187 142-18-7 1-Monolaurin 0 0 0 1 0 0 0 C142314 142-31-4 Sodium octyl sulfate 0 0 0 1 0 0 0 C142621 142-62-1 Hexanoic acid 0 0 0 1 0 0 0 C142870 142-87-0 Sodium decyl sulfate 0 0 0 1 0 0 0 C143088 143-08-8 1-Nonanol 0 0 0 1 0 0 0 C14765301 14765-30-1 2-sec-Butylcyclohexanone 0 0 0 1 0 0 0 C14901076 14901-07-6 4-(2,6,6-Trimethyl-cyclohex-1-enyl)-but-3-en-2-one 0 0 0 1 0 0 0 C15046750 15046-75-0 Sodium 2-methylbenzenesulfonate 0 0 0 1 0 0 0 C150787 150-78-7 Hydroquinone dimethyl ether 0 0 0 1 0 0 0 C151053 151-05-3 Dimethylbenzylcarbinyl acetate 0 0 0 1 0 0 0 C1632731 1632-73-1 Fenchol 0 0 0 1 0 0 0 C163520330 163520-33-0 Isoxadifen-ethyl 0 0 0 1 0 0 0 C17465860 17465-86-0 gamma-Cyclodextrin 0 0 0 1 0 0 0 C18172673 18172-67-3 (-)-beta-Pinene 0 0 0 1 0 0 0 C1843056 1843-05-6 Octabenzone 0 0 0 1 0 0 0 C20780487 20780-48-7 3,7-Dimethyloctan-3-yl acetate 0 0 0 1 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 26**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C2078548 2078-54-8 Propofol 0 0 0 1 0 0 0 C21662099 21662-09-9 (4Z)-4-Decenal 0 0 0 1 0 0 0 C2416946 2416-94-6 2,3,6-Trimethylphenol 0 0 0 1 0 0 0 C24851987 24851-98-7 Methyl dihydrojasmonate 0 0 0 1 0 0 0 C25322694 25322-69-4 Polypropylene glycol 0 0 0 1 0 0 0 C25496724 25496-72-4 Glyceryl monooleate 0 0 0 1 0 0 0 C25498491 25498-49-1 Tripropylene glycol monomethyl ether 0 0 0 1 0 0 0 C25638179 25638-17-9 Butylnaphthalenesulfonic acid sodium salt 0 0 0 1 0 0 0 C2687947 2687-94-7 N-Octy l-2-pyrrolidone 0 0 0 1 0 0 0 C2756561 2756-56-1 Isobornyl propanoate 0 0 0 1 0 0 0 C3147759 3147-75-9 Octrizole 0 0 0 1 0 0 0 C34451199 34451-19-9 Butyl (2S)-2-hydroxypropanoate 0 0 0 1 0 0 0 C3452979 3452-97-9 3,5,5-Trimethyl-1-hexanol 0 0 0 1 0 0 0 C34590948 34590-94-8 Propanol, 1(or 2)-(2-methoxymethylethoxy)- 0 0 0 1 0 0 0 C36653824 36653-82-4 1-Hexadecanol 0 0 0 1 0 0 0 C3681718 3681-71-8 (3Z)-3-Hexenyl acetate 0 0 0 1 0 0 0 C3734336 3734-33-6 Denatonium benzoate 0 0 0 1 0 0 0 C37764253 37764-25-3 Dichlormid 0 0 0 1 0 0 0 C4180238 4180-23-8 (E)-Anethole 0 0 0 1 0 0 0 C464493 464-49-3 D-Camphor 0 0 0 1 0 0 0 C470826 470-82-6 1,8-Cineol 0 0 0 1 0 0 0 C499752 499-75-2 Isopropyl-o-cresol 0 0 0 1 0 0 0 C499832 499-83-2 2,6-Pyridinedicarboxylic acid 0 0 0 1 0 0 0 C50215 50-21-5 Lactic acid 0 0 0 1 0 0 0 C50704 50-70-4 D-Glucitol 0 0 0 1 0 0 0 C50817 50-81-7 L-Ascorbic acid 0 0 0 1 0 0 0 C52225204 52225-20-4 dl-alpha-Tocopheryl acetate 0 0 0 1 0 0 0 C526750 526-75-0 2,3-Dimethylphenol 0 0 0 1 0 0 0 C527606 527-60-6 2,4,6-Trimethylphenol 0 0 0 1 0 0 0 C53219219 53219-21-9 7-Octen-2-ol, 2-methyl-6-methylene-, dihydro deriv. 0 0 0 1 0 0 0 C532321 532-32-1 Sodium benzoate 0 0 0 1 0 0 0 C540181 540-18-1 Pentyl butyrate 0 0 0 1 0 0 0 C544638 544-63-8 Tetradecanoic acid 0 0 0 1 0 0 0 C544763 544-76-3 Hexadecane 0 0 0 1 0 0 0 C5536618 5536-61-8 Sodium methacrylate 0 0 0 1 0 0 0 C556672 556-67-2 Octamethylcyclotetrasiloxane 0 0 0 1 0 0 0 C576261 576-26-1 2,6-Dimethylphenol 0 0 0 1 0 0 0 C58430947 58430-94-7 3,5,5-Trimethylhexyl acetate 0 0 0 1 0 0 0 C58560 58-56-0 Pyridoxine hydrochloride 0 0 0 1 0 0 0 C589684 589-68-4 Tetradecanoic acid, 2,3-dihydroxypropyl ester 0 0 0 1 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 27**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C59303 59-30-3 Folic acid 0 0 0 1 0 0 0 C60128 60-12-8 2-Phenylethanol 0 0 0 1 0 0 0 C609541 609-54-1 2,5-Dimethylbenzenesulfonic acid 0 0 0 1 0 0 0 C6152336 6152-33-6 Sodium 2-phenylphenate tetrahydrate 0 0 0 1 0 0 0 C61791126 61791-12-6 Cremophor(R) EL 0 0 0 1 0 0 0 C620177 620-17-7 3-Ethylphenol 0 0 0 1 0 0 0 C627930 627-93-0 Dimethyl adipate 0 0 0 1 0 0 0 C628637 628-63-7 Pentyl acetate 0 0 0 1 0 0 0 C629629 629-62-9 Pentadecane 0 0 0 1 0 0 0 C63423 63-42-3 Lactose 0 0 0 1 0 0 0 C65236 65-23-6 Pyridoxine 0 0 0 1 0 0 0 C657841 657-84-1 Sodium 4-methylbenzenesulfonate 0 0 0 1 0 0 0 C6728263 6728-26-3 (2E)-2-Hexenal 0 0 0 1 0 0 0 C67685 67-68-5 Dimethyl sulfoxide 0 0 0 1 0 0 0 C6789884 6789-88-4 Hexyl benzoate 0 0 0 1 0 0 0 C692864 692-86-4 Ethyl undec-10-enoate 0 0 0 1 0 0 0 C695067 695-06-7 gamma-Caprolactone 0 0 0 1 0 0 0 C7011838 7011-83-8 2(3H)-Furanone, 5-hexyldihydro-5-methyl- 0 0 0 1 0 0 0 C706149 706-14-9 gamma-Decanolactone 0 0 0 1 0 0 0 C71238 71-23-8 1-Propanol 0 0 0 1 0 0 0 C71526073 71526-07-3 MON-4660 0 0 0 1 0 0 0 C73223 73-22-3 l-Tryptophan 0 0 0 1 0 0 0 C7540514 7540-51-4 (S)-(-)-beta-Citronellol 0 0 0 1 0 0 0 C7632000 7632-00-0 Sodium nitrite 0 0 0 1 0 0 0 C76493 76-49-3 Bornyl acetate 0 0 0 1 0 0 0 C7681825 7681-82-5 Sodium iodide 0 0 0 1 0 0 0 C7785264 7785-26-4 (-)-alpha-Pinene 0 0 0 1 0 0 0 C77907 77-90-7 Acetyl tributyl citrate 0 0 0 1 0 0 0 C78400 78-40-0 Triethyl phosphate 0 0 0 1 0 0 0 C78693 78-69-3 3,7-Dimethyl-3-octanol 0 0 0 1 0 0 0 C79925 79-92-5 2,2-Dimethyl-3-methylenebicyclo[2.2.1]heptane 0 0 0 1 0 0 0 C8000417 8000-41-7 Terpineol 0 0 0 1 0 0 0 C80273 80-27-3 Terpinyl propionate 0 0 0 1 0 0 0 C80568 80-56-8 alpha-Pinene 0 0 0 1 0 0 0 C87252 87-25-2 Ethyl anthranilate 0 0 0 1 0 0 0 C87694 87-69-4 L-Tartaric acid 0 0 0 1 0 0 0 C88415 88-41-5 2-tert-Butylcyclohexyl acetate 0 0 0 1 0 0 0 C88697 88-69-7 2-Isopropylphenol 0 0 0 1 0 0 0 C89725 89-72-5 2-(Butan-2-yl)phenol 0 0 0 1 0 0 0 C89781 89-78-1 dl-Menthol 0 0 0 1 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 28**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C90006 90-00-6 2-Ethylphenol 0 0 0 1 0 0 0 C9004960 9004-96-0 Polyoxyethylene monoleate 0 0 0 1 0 0 0 C90051 90-05-1 2-Methoxyphenol 0 0 0 1 0 0 0 C9005656 9005-65-6 Polysorbate 80 0 0 0 1 0 0 0 C90120 90-12-0 1-Methylnaphthalene 0 0 0 1 0 0 0 C9016006 9016-00-6 Polydimethylsiloxane 0 0 0 1 0 0 0 C91623 91-62-3 6-Methylquinoline 0 0 0 1 0 0 0 C91645 91-64-5 Coumarin 0 0 0 1 0 0 0 C92524 92-52-4 Biphenyl 0 0 0 1 0 0 0 C928961 928-96-1 (Z)-3-Hexen-1-ol 0 0 0 1 0 0 0 C93890 93-89-0 Ethyl benzoate 0 0 0 1 0 0 0 C93925 93-92-5 Benzenemethanol, alpha-methyl-, acetate 0 0 0 1 0 0 0 C95169 95-16-9 Benzothiazole 0 0 0 1 0 0 0 C95636 95-63-6 1,2,4-Trimethylbenzene 0 0 0 1 0 0 0 C95658 95-65-8 3,4-Dimethylphenol 0 0 0 1 0 0 0 C95874 95-87-4 2,5-Dimethylphenol 0 0 0 1 0 0 0 C96480 96-48-0 4-Butyrolactone 0 0 0 1 0 0 0 C97789 97-78-9 N-Dodecanoyl-N-methylglycine 0 0 0 1 0 0 0 C97994 97-99-4 Tetrahydrofurfuryl alcohol 0 0 0 1 0 0 0 C98511 98-51-1 4-tert-Butyltoluene 0 0 0 1 0 0 0 C98522 98-52-2 4-tert-Butylcyclohexanol 0 0 0 1 0 0 0 C98533 98-53-3 4-tert-Butylcyclohexanone 0 0 0 1 0 0 0 C98862 98-86-2 Acetophenone 0 0 0 1 0 0 0 C98920 98-92-0 Niacinamide 0 0 0 1 0 0 0 C99607702 99607-70-2 Cloquintocet-mexyl 0 0 0 1 0 0 0 C99854 99-85-4 gamma-Terpinene 0 0 0 1 0 0 0 C99876 99-87-6 p-Cymene 0 0 0 1 0 0 0 C100005 100-00-5 1-Chloro-4-nitrobenzene 0 0 0 0 0 0 0 C100027 100-02-7 4-Nitrophenol 0 0 0 0 0 0 0 C100210 100-21-0 Terephthalic acid 0 0 0 0 0 0 0 C100378 100-37-8 N,N-Diethylethanolamine 0 0 0 0 0 0 0 C10042598 10042-59-8 2-Propyl-1-heptanol 0 0 0 0 0 0 0 C100549 100-54-9 3-Pyridinecarbonitrile 0 0 0 0 0 0 0 C100641 100-64-1 Cyclohexanone oxime 0 0 0 0 0 0 0 C10081671 10081-67-1 4-(2-Phenylpropan-2-yl)-N-[4-(2-phenylpropan-2-yl)phenyl]aniline 0 0 0 0 0 0 0 C1008726 1008-72-6 Sodium 2-formylbenzenesulfonate 0 0 0 0 0 0 0 C101100 101-10-0 Cloprop 0 0 0 0 0 0 0 C101428 101-42-8 Fenuron 0 0 0 0 0 0 0 C101463698 101463-69-8 Flufenoxuron 0 0 0 0 0 0 0 C101837 101-83-7 Dicyclohexylamine 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 29**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C102272 102-27-2 N-Ethyl-3-methylaniline 0 0 0 0 0 0 0 C102829 102-82-9 Tributylamine 0 0 0 0 0 0 0 C103093 103-09-3 2-Ethylhexyl acetate 0 0 0 0 0 0 0 C103242 103-24-2 Bis(2-ethylhexyl) nonanedioate 0 0 0 0 0 0 0 C103333 103-33-3 Azobenzene 0 0 0 0 0 0 0 C103344 103-34-4 4,4'-Dithiodimorpholine 0 0 0 0 0 0 0 C103695 103-69-5 N-Ethylaniline 0 0 0 0 0 0 0 C103764 103-76-4 1-Piperazineethanol 0 0 0 0 0 0 0 C104518 104-51-8 Butylbenzene 0 0 0 0 0 0 0 C104665 104-66-5 1,2-Diphenoxyethane 0 0 0 0 0 0 0 C104795688 104795-68-8 CI-959 0 0 0 0 0 0 0 C105602 105-60-2 Caprolactam 0 0 0 0 0 0 0 C105997 105-99-7 Dibutyl hexanedioate 0 0 0 0 0 0 0 C106434 106-43-4 4-Chlorotoluene 0 0 0 0 0 0 0 C106456 106-45-6 4-Thiocresol 0 0 0 0 0 0 0 C106490 106-49-0 4-Methylaniline 0 0 0 0 0 0 0 C1067250 1067-25-0 Trimethoxypropylsilane 0 0 0 0 0 0 0 C1067534 1067-53-4 Tris(2-methoxyethoxy)vinylsilane 0 0 0 0 0 0 0 C106876 106-87-6 4-Vinyl-1-cyclohexene dioxide 0 0 0 0 0 0 0 C1068967963 1068967-96-3 SAR102608 0 0 0 0 0 0 0 C107073 107-07-3 2-Chloroethanol 0 0 0 0 0 0 0 C107131 107-13-1 Acrylonitrile 0 0 0 0 0 0 0 C107200 107-20-0 Chloroacetaldehyde 0 0 0 0 0 0 0 C107460 107-46-0 Hexamethyldisiloxane 0 0 0 0 0 0 0 C107517 107-51-7 Octamethyltrisiloxane 0 0 0 0 0 0 0 C1076977 1076-97-7 1,4-Cyclohexanedicarboxylic acid 0 0 0 0 0 0 0 C108010 108-01-0 Dimethylaminoethanol 0 0 0 0 0 0 0 C108112 108-11-2 4-Methyl-2-pentanol 0 0 0 0 0 0 0 C108383 108-38-3 1,3-Dimethylbenzene 0 0 0 0 0 0 0 C108441 108-44-1 3-Methylaniline 0 0 0 0 0 0 0 C108452 108-45-2 1,3-Benzenediamine 0 0 0 0 0 0 0 C108598 108-59-8 Dimethyl malonate 0 0 0 0 0 0 0 C108805 108-80-5 Cyanuric acid 0 0 0 0 0 0 0 C108918 108-91-8 Cyclohexylamine 0 0 0 0 0 0 0 C108930 108-93-0 Cyclohexanol 0 0 0 0 0 0 0 C109024 109-02-4 4-Methylmorpholine 0 0 0 0 0 0 0 C109433 109-43-3 Dibutyl decanedioate 0 0 0 0 0 0 0 C109466 109-46-6 N,N'-Dibutylthiourea 0 0 0 0 0 0 0 C109557 109-55-7 3-(Dimethylamino)propylamine 0 0 0 0 0 0 0 C1095905 1095-90-5 Methadone hydrochloride 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 30**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C109773 109-77-3 Propanedinitrile 0 0 0 0 0 0 0 C110054 110-05-4 Di-tert-butyl peroxide 0 0 0 0 0 0 0 C110123 110-12-3 5-Methyl-2-hexanone 0 0 0 0 0 0 0 C110156 110-15-6 Butanedioic acid 0 0 0 0 0 0 0 C110269 110-26-9 N,N'-Methylenebisacrylamide 0 0 0 0 0 0 0 C110338 110-33-8 Dihexyl hexanedioate 0 0 0 0 0 0 0 C110634 110-63-4 1,4-Butanediol 0 0 0 0 0 0 0 C110656 110-65-6 2-Butyne-1,4-diol 0 0 0 0 0 0 0 C110690 110-69-0 Butanal oxime 0 0 0 0 0 0 0 C110736 110-73-6 2-(Ethylamino)ethanol 0 0 0 0 0 0 0 C110805 110-80-5 2-Ethoxyethanol 0 0 0 0 0 0 0 C110850 110-85-0 Piperazine 0 0 0 0 0 0 0 C110872 110-87-2 3,4-Dihydro-2H-pyran 0 0 0 0 0 0 0 C110918 110-91-8 Morpholine 0 0 0 0 0 0 0 C111159 111-15-9 2-Ethoxyethyl acetate 0 0 0 0 0 0 0 C111206 111-20-6 Decanedioic acid 0 0 0 0 0 0 0 C111217 111-21-7 Triethylene glycol diacetate 0 0 0 0 0 0 0 C1112396 1112-39-6 Dimethoxydimethylsilane 0 0 0 0 0 0 0 C111444 111-44-4 Bis(2-chloroethyl) ether 0 0 0 0 0 0 0 C111499 111-49-9 Hexamethyleneimine 0 0 0 0 0 0 0 C111557 111-55-7 1,2-Ethanediol diacetate 0 0 0 0 0 0 0 C111693 111-69-3 Hexanedinitrile 0 0 0 0 0 0 0 C111812589 111812-58-9 Fenpyroximate (Z,E) 0 0 0 0 0 0 0 C111842 111-84-2 Nonane 0 0 0 0 0 0 0 C1118463 1118-46-3 Butyltin trichloride 0 0 0 0 0 0 0 C111966 111-96-6 Bis(2-methoxyethyl) ether 0 0 0 0 0 0 0 C111988499 111988-49-9 Thiacloprid 0 0 0 0 0 0 0 C1120010 1120-01-0 Sodium hexyldecyl sulfate 0 0 0 0 0 0 0 C1120714 1120-71-4 1,3-Propane sultone 0 0 0 0 0 0 0 C112072 112-07-2 2-Butoxyethyl acetate 0 0 0 0 0 0 0 C112185 112-18-5 N,N-Dimethyldodecan-1-amine 0 0 0 0 0 0 0 C112226616 112226-61-6 Halofenozide 0 0 0 0 0 0 0 C112254 112-25-4 2-(Hexyloxy)ethanol 0 0 0 0 0 0 0 C112356 112-35-6 2-[2-(2-Methoxyethoxy)ethoxy]ethanol 0 0 0 0 0 0 0 C112492 112-49-2 Triethylene glycol dimethyl ether 0 0 0 0 0 0 0 C112505 112-50-5 2-[2-(2-Ethoxyethoxy)ethoxy]ethanol 0 0 0 0 0 0 0 C112550 112-55-0 1-Dodecanethiol 0 0 0 0 0 0 0 C112607 112-60-7 Tetraethylene glycol 0 0 0 0 0 0 0 C112733069 112733-06-9 Zenarestat 0 0 0 0 0 0 0 C112809515 112809-51-5 Letrozole 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 31**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C113734182 113734-18-2 CP-114271 0 0 0 0 0 0 0 C1143380 1143-38-0 Anthralin 0 0 0 0 0 0 0 C115286 115-28-6 Chlorendic acid 0 0 0 0 0 0 0 C115968 115-96-8 Tris(2-chloroethyl) phosphate 0 0 0 0 0 0 0 C117088 117-08-8 Tetrachlorophthalic anhydride 0 0 0 0 0 0 0 C117840 117-84-0 Dioctyl phthalate 0 0 0 0 0 0 0 C118134308 118134-30-8 Spiroxamine 0 0 0 0 0 0 0 C118478 118-47-8 1H-Pyrazole-3-carboxylic acid, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)- 0 0 0 0 0 0 0 C118796 118-79-6 2,4,6-Tribromophenol 0 0 0 0 0 0 0 C1189088 1189-08-8 1,3-Butyleneglycol dimethacrylate 0 0 0 0 0 0 0 C118934 118-93-4 2-Hydroxyacetophenone 0 0 0 0 0 0 0 C119073 119-07-3 Octy l decyl phthalate 0 0 0 0 0 0 0 C1192525 1192-52-5 4,5-Dichloro-3H-1,2-dithiol-3-one 0 0 0 0 0 0 0 C119539 119-53-9 Benzoin 0 0 0 0 0 0 0 C119642 119-64-2 Tetralin 0 0 0 0 0 0 0 C119904 119-90-4 3,3'-Dimethoxybenzidine 0 0 0 0 0 0 0 C120183 120-18-3 Naphthalene-2-sulfonic acid 0 0 0 0 0 0 0 C120365 120-36-5 Dichlorprop 0 0 0 0 0 0 0 C120558 120-55-8 Diethylene glycol dibenzoate 0 0 0 0 0 0 0 C120616 120-61-6 Dimethyl terephthalate 0 0 0 0 0 0 0 C120718 120-71-8 2-Methoxy-5-methylaniline 0 0 0 0 0 0 0 C12108133 12108-13-3 Manganese, tricarbonyl[(1,2,3,4,5-.eta.)-1-methyl-2,4-cyclopentadien-1-yl]- 0 0 0 0 0 0 0 C121142 121-14-2 2,4-Dinitrotoluene 0 0 0 0 0 0 0 C121697 121-69-7 N,N-Dimethylaniline 0 0 0 0 0 0 0 C121915 121-91-5 1,3-Benzenedicarboxylic acid 0 0 0 0 0 0 0 C122429 122-42-9 Propham 0 0 0 0 0 0 0 C122510 122-51-0 Ethyl orthoformate 0 0 0 0 0 0 0 C122576 122-57-6 Methyl styryl ketone 0 0 0 0 0 0 0 C122667 122-66-7 1,2-Diphenylhydrazine 0 0 0 0 0 0 0 C123002 123-00-2 4-Morpholinepropanamine 0 0 0 0 0 0 0 C123057 123-05-7 2-Ethylhexanal 0 0 0 0 0 0 0 C123122554 123122-55-4 Candoxatril 0 0 0 0 0 0 0 C123251 123-25-1 Diethyl butanedioate 0 0 0 0 0 0 0 C123319 123-31-9 Hydroquinone 0 0 0 0 0 0 0 C123422 123-42-2 Diacetone alcohol 0 0 0 0 0 0 0 C123773 123-77-3 Azodicarbonamide 0 0 0 0 0 0 0 C123966 123-96-6 2-Octanol 0 0 0 0 0 0 0 C123999 123-99-9 Nonanedioic acid 0 0 0 0 0 0 0 C124049 124-04-9 Hexanedioic acid 0 0 0 0 0 0 0 C124094 124-09-4 1,6-Hexanediamine 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 32**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C12427382 12427-38-2 Maneb 0 0 0 0 0 0 0 C124378774 124378-77-4 Enadoline 0 0 0 0 0 0 0 C124403 124-40-3 Dimethylamine 0 0 0 0 0 0 0 C124685 124-68-5 2-Amino-2-methylpropan-1-ol 0 0 0 0 0 0 0 C125848 125-84-8 Aminoglutethimide 0 0 0 0 0 0 0 C1260179 1260-17-9 Carminic acid 0 0 0 0 0 0 0 C126307 126-30-7 2,2-Dimethylpropane-1,3-diol 0 0 0 0 0 0 0 C126727 126-72-7 Tris(2,3-dibromopropyl) phosphate 0 0 0 0 0 0 0 C126738 126-73-8 Tributyl phosphate 0 0 0 0 0 0 0 C126987 126-98-7 Methacrylonitrile 0 0 0 0 0 0 0 C127071 127-07-1 Hydroxyurea 0 0 0 0 0 0 0 C127195 127-19-5 N,N-Dimethylacetamide 0 0 0 0 0 0 0 C127479 127-47-9 Retinol acetate 0 0 0 0 0 0 0 C128950 128-95-0 1,4-Diaminoanthraquinone 0 0 0 0 0 0 0 C129000 129-00-0 Pyrene 0 0 0 0 0 0 0 C129066 129-06-6 Sodium warfarin 0 0 0 0 0 0 0 C1300738 1300-73-8 Dimethylaniline 0 0 0 0 0 0 0 C130143 130-14-3 Sodium 1-naphthalenesulfonate 0 0 0 0 0 0 0 C1303113 1303-11-3 Indium arsenide 0 0 0 0 0 0 0 C131704 131-70-4 Monobutyl phthalate 0 0 0 0 0 0 0 C1320076 1320-07-6 C.I. Acid Orange 24, monosodium salt 0 0 0 0 0 0 0 C1321740 1321-74-0 Divinylbenzene 0 0 0 0 0 0 0 C13292461 13292-46-1 Rifampicin 0 0 0 0 0 0 0 C1330785 1330-78-5 Tricresyl phosphate 0 0 0 0 0 0 0 C1330865 1330-86-5 Diisooctyl adipate 0 0 0 0 0 0 0 C13311847 13311-84-7 Flutamide 0 0 0 0 0 0 0 C1333397 1333-39-7 Phenolsulfonic acid 0 0 0 0 0 0 0 C133904 133-90-4 Chloramben 0 0 0 0 0 0 0 C134002601 134002-60-1 CP-085958 0 0 0 0 0 0 0 C134032 134-03-2 Sodium L-ascorbate 0 0 0 0 0 0 0 C134523038 134523-03-8 Atorvastatin calcium 0 0 0 0 0 0 0 C134605644 134605-64-4 Butafenacil 0 0 0 0 0 0 0 C136607 136-60-7 Butyl benzoate 0 0 0 0 0 0 0 C13674845 13674-84-5 Tris(2-chloroisopropyl)phosphate 0 0 0 0 0 0 0 C13674878 13674-87-8 Tris(1,3-dichloro-2-propyl)phosphate 0 0 0 0 0 0 0 C13755298 13755-29-8 Sodium tetrafluoroborate 0 0 0 0 0 0 0 C139149556 139149-55-6 SB202235 0 0 0 0 0 0 0 C139290656 139290-65-6 Volinanserin 0 0 0 0 0 0 0 C139340560 139340-56-0 Darbufelone mesylate 0 0 0 0 0 0 0 C139877 139-87-7 Ethyl diethanolamine 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 33**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C140089 140-08-9 Tris(2-chloroethyl) phosphite 0 0 0 0 0 0 0 C140385 140-38-5 4-Chlorophenylurea 0 0 0 0 0 0 0 C140567 140-56-7 Fenaminosulf 0 0 0 0 0 0 0 C140647 140-64-7 Pentamidine isethionate 0 0 0 0 0 0 0 C140670 140-67-0 Estragole 0 0 0 0 0 0 0 C140954 140-95-4 Dimethylolurea 0 0 0 0 0 0 0 C141048 141-04-8 Diisobutyl adipate 0 0 0 0 0 0 0 C141322 141-32-2 Butyl acrylate 0 0 0 0 0 0 0 C141435 141-43-5 Ethanolamine 0 0 0 0 0 0 0 C142041 142-04-1 Aniline hydrochloride 0 0 0 0 0 0 0 C142165 142-16-5 Bis(2-ethylhexyl) maleate 0 0 0 0 0 0 0 C14233375 14233-37-5 1,4-Bis(N-isopropylamino)anthraquinone 0 0 0 0 0 0 0 C143226 143-22-6 2-[2-(2-Butoxyethoxy)ethoxy]ethanol 0 0 0 0 0 0 0 C1434544 1434-54-4 Pregnenolone carbonitrile 0 0 0 0 0 0 0 C144490 144-49-0 Fluoroacetic acid 0 0 0 0 0 0 0 C1445756 1445-75-6 Diisopropyl methylphosphonate 0 0 0 0 0 0 0 C145742285 145742-28-5 CP-122721 0 0 0 0 0 0 0 C1459934 1459-93-4 Dimethyl isophthalate 0 0 0 0 0 0 0 C147240 147-24-0 Diphenhydramine hydrochloride 0 0 0 0 0 0 0 C1477550 1477-55-0 1,3-Benzenedimethanamine 0 0 0 0 0 0 0 C148243 148-24-3 8-Hydroxyquinoline 0 0 0 0 0 0 0 C149062759 149062-75-9 PharmaGSID_47259 0 0 0 0 0 0 0 C149304 149-30-4 2-Mercaptobenzothiazole 0 0 0 0 0 0 0 C149575 149-57-5 2-Ethylhexanoic acid 0 0 0 0 0 0 0 C149979419 149979-41-9 Tepraloxydim 0 0 0 0 0 0 0 C150130 150-13-0 4-Aminobenzoic acid 0 0 0 0 0 0 0 C150685 150-68-5 Monuron 0 0 0 0 0 0 0 C150765 150-76-5 4-Methoxyphenol 0 0 0 0 0 0 0 C15214898 15214-89-8 2-Acrylamido-2-methyl-1-propanesulfonic acid 0 0 0 0 0 0 0 C15310017 15310-01-7 Benodanil 0 0 0 0 0 0 0 C1541817 1541-81-7 4-Dodecylmorpholine 0 0 0 0 0 0 0 C154427 154-42-7 6-Thioguanine 0 0 0 0 0 0 0 C15499271 15499-27-1 4-Butylchlorobenzene 0 0 0 0 0 0 0 C1559348 1559-34-8 3,6,9,12-Tetraoxahexadecan-1-ol 0 0 0 0 0 0 0 C1563388 1563-38-8 2,3-Dihydro-2,2-dimethyl-7-benzofuranol 0 0 0 0 0 0 0 C156434 156-43-4 4-Ethoxyaniline 0 0 0 0 0 0 0 C1569013 1569-01-3 1-Propoxy-2-propanol 0 0 0 0 0 0 0 C16219753 16219-75-3 5-Ethylidene-2-norbornene 0 0 0 0 0 0 0 C1625918 1625-91-8 4,4'-Di-tert-butylbiphenyl 0 0 0 0 0 0 0 C162706141 162706-14-1 UK-156819 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 34**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C1634782 1634-78-2 Malaoxon 0 0 0 0 0 0 0 C16423680 16423-68-0 FD&C Red 3 0 0 0 0 0 0 0 C1646759 1646-75-9 Aldicarb oxime 0 0 0 0 0 0 0 C1646873 1646-87-3 Aldicarb sulfoxide 0 0 0 0 0 0 0 C1646884 1646-88-4 Aldoxycarb 0 0 0 0 0 0 0 C166412788 166412-78-8 Diisononyl cyclohexane-1,2-dicarboxylate 0 0 0 0 0 0 0 C1675543 1675-54-3 Bisphenol A diglycidyl ether 0 0 0 0 0 0 0 C16893859 16893-85-9 Sodium hexafluorosilicate 0 0 0 0 0 0 0 C1742149 1742-14-9 1,1-Bis(3,4-dimethylphenyl)ethane 0 0 0 0 0 0 0 C1760243 1760-24-3 N-[3-(Trimethoxysilyl)propyl]ethane-1,2-diamine 0 0 0 0 0 0 0 C1762954 1762-95-4 Thiocyanic acid, ammonium salt 0 0 0 0 0 0 0 C177785476 177785-47-6 PharmaGSID_47261 0 0 0 0 0 0 0 C17804352 17804-35-2 Benomyl 0 0 0 0 0 0 0 C181640095 181640-09-5 SR144190 0 0 0 0 0 0 0 C1825214 1825-21-4 Pentachloroanisole 0 0 0 0 0 0 0 C1836755 1836-75-5 Nitrofen 0 0 0 0 0 0 0 C184653847 184653-84-7 Carabersat 0 0 0 0 0 0 0 C1873887 1873-88-7 1,1,1,3,5,5,5-Heptamethyltrisiloxane 0 0 0 0 0 0 0 C189003927 189003-92-7 Trelanserin 0 0 0 0 0 0 0 C1907659 1907-65-9 N-Butyl-p-toluenesulfonamide 0 0 0 0 0 0 0 C1936158 1936-15-8 C.I. Acid Orange 10 0 0 0 0 0 0 0 C194098254 194098-25-4 CP-409092 0 0 0 0 0 0 0 C197077557 197077-55-7 UK-333747 0 0 0 0 0 0 0 C19780111 19780-11-1 (2-Dodecenyl)succinic anhydride 0 0 0 0 0 0 0 C199171885 199171-88-5 CP-401387 0 0 0 0 0 0 0 C199584388 199584-38-8 1-Methoxy-4-tert-pentylcyclohexane 0 0 0 0 0 0 0 C2008415 2008-41-5 Butylate 0 0 0 0 0 0 0 C200940234 200940-23-4 SB243213A 0 0 0 0 0 0 0 C2016571 2016-57-1 1-Decanamine 0 0 0 0 0 0 0 C2031676 2031-67-6 Triethoxymethylsilane 0 0 0 0 0 0 0 C20325400 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride 0 0 0 0 0 0 0 C2043574 2043-57-4 1H,1H,2H,2H-Perfluorooctyl iodide 0 0 0 0 0 0 0 C2044646 2044-64-6 N,N-Dimethylacetoacetamide 0 0 0 0 0 0 0 C207736058 207736-05-8 CI-1029 0 0 0 0 0 0 0 C208968 208-96-8 Acenaphthylene 0 0 0 0 0 0 0 C210826407 210826-40-7 CP-456773 0 0 0 0 0 0 0 C214535770 214535-77-0 CP-457677 0 0 0 0 0 0 0 C215297271 215297-27-1 UK-343664 0 0 0 0 0 0 0 C21725462 21725-46-2 Cyanazine 0 0 0 0 0 0 0 C2176627 2176-62-7 Pentachloropyridine 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 35**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C22047490 22047-49-0 2-Ethylhexyl octadecanoate 0 0 0 0 0 0 0 C220860504 220860-50-4 CP-457920 0 0 0 0 0 0 0 C221246124 221246-12-4 Fandosentan potassium salt 0 0 0 0 0 0 0 C2212671 2212-67-1 Molinate 0 0 0 0 0 0 0 C22224926 22224-92-6 Fenamiphos 0 0 0 0 0 0 0 C2231574 2231-57-4 Thiocarbazide 0 0 0 0 0 0 0 C2243621 2243-62-1 1,5-Naphthalenediamine 0 0 0 0 0 0 0 C2244215 2244-21-5 Potassium dichloroisocyanurate 0 0 0 0 0 0 0 C22781233 22781-23-3 Bendiocarb 0 0 0 0 0 0 0 C23089261 23089-26-1 Levomenol 0 0 0 0 0 0 0 C230954093 230954-09-3 CP-544439 0 0 0 0 0 0 0 C23103982 23103-98-2 Pirimicarb 0 0 0 0 0 0 0 C23386529 23386-52-9 Dicyclohexyl sodium sulfosuccinate 0 0 0 0 0 0 0 C23564069 23564-06-9 Thiophanate 0 0 0 0 0 0 0 C23779320 23779-32-0 1-[3-(Triethoxysilyl)propyl]urea 0 0 0 0 0 0 0 C2385855 2385-85-5 Mirex 0 0 0 0 0 0 0 C2392394 2392-39-4 Dexamethasone sodium phosphate 0 0 0 0 0 0 0 C2425061 2425-06-1 Captafol 0 0 0 0 0 0 0 C2426086 2426-08-6 Butyl glycidyl ether 0 0 0 0 0 0 0 C2432873 2432-87-3 Dioctyl succinate 0 0 0 0 0 0 0 C2445774 2445-77-4 2-Methylbutyl isovalerate 0 0 0 0 0 0 0 C2451629 2451-62-9 Triglycidyl isocyanurate 0 0 0 0 0 0 0 C24602866 24602-86-6 Tridemorph 0 0 0 0 0 0 0 C24800440 24800-44-0 Tripropylene glycol 0 0 0 0 0 0 0 C2492264 2492-26-4 Sodium 2-mercaptobenzothiolate 0 0 0 0 0 0 0 C25168052 25168-05-2 Chlorotoluene 0 0 0 0 0 0 0 C2528167 2528-16-7 Monobenzyl phthalate 0 0 0 0 0 0 0 C253450098 253450-09-8 Besonprodil 0 0 0 0 0 0 0 C25360105 25360-10-5 tert-Nonanethiol 0 0 0 0 0 0 0 C25812300 25812-30-0 Gemfibrozil 0 0 0 0 0 0 0 C261947380 261947-38-0 CP-532623 0 0 0 0 0 0 0 C2627954 2627-95-4 1,3-Divinyl-1,1,3,3-tetramethyl disiloxane 0 0 0 0 0 0 0 C263553339 263553-33-9 GW 473178E methyl benzene sulphonic acid 0 0 0 0 0 0 0 C264618442 264618-44-2 SSR146977 0 0 0 0 0 0 0 C26628228 26628-22-8 Sodium azide 0 0 0 0 0 0 0 C2675776 2675-77-6 Chloroneb 0 0 0 0 0 0 0 C2687254 2687-25-4 2,3-Diaminotoluene 0 0 0 0 0 0 0 C26896208 26896-20-8 Neodecanoic acid 0 0 0 0 0 0 0 C2694544 2694-54-4 Triprop-2-en-1-yl benzene-1,2,4-tricarboxylate 0 0 0 0 0 0 0 C2696846 2696-84-6 4-Propylaniline 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 36**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C27090637 27090-63-7 N,N,N',N'-Tetrabutyl-1,6-hexanediamine 0 0 0 0 0 0 0 C27178161 27178-16-1 Diisodecyl hexanedioate 0 0 0 0 0 0 0 C271896 271-89-6 2,3-Benzofuran 0 0 0 0 0 0 0 C2761242 2761-24-2 Triethoxypentylsilane 0 0 0 0 0 0 0 C2783940 2783-94-0 FD&C Yellow 6 0 0 0 0 0 0 0 C2795393 2795-39-3 PFOS-K 0 0 0 0 0 0 0 C2807309 2807-30-9 2-Propoxyethanol 0 0 0 0 0 0 0 C2835952 2835-95-2 5-Amino-2-methylphenol 0 0 0 0 0 0 0 C28631665 28631-66-5 C.I. Acid Blue 22 0 0 0 0 0 0 0 C28804888 28804-88-8 Dimethylnaphthalene 0 0 0 0 0 0 0 C288324 288-32-4 Imidazole 0 0 0 0 0 0 0 C29122687 29122-68-7 Atenolol 0 0 0 0 0 0 0 C2917739 2917-73-9 Dibutyl nonanedioate 0 0 0 0 0 0 0 C29385431 29385-43-1 Tolyltriazole 0 0 0 0 0 0 0 C29387868 29387-86-8 Propylene glycol monobutyl ether 0 0 0 0 0 0 0 C29420493 29420-49-3 PFBS-K 0 0 0 0 0 0 0 C2943751 2943-75-1 Triethoxyoctylsilane 0 0 0 0 0 0 0 C29590429 29590-42-9 Isooctyl acrylate 0 0 0 0 0 0 0 C298198524 298198-52-4 SSR180711 0 0 0 0 0 0 0 C29836268 29836-26-8 Octy l beta-D-glucopyranoside 0 0 0 0 0 0 0 C298464 298-46-4 Carbamazepine 0 0 0 0 0 0 0 C2996921 2996-92-1 Trimethoxyphenylsilane 0 0 0 0 0 0 0 C3033770 3033-77-0 N,N,N-Trimethyl(oxiran-2-yl)methanaminium chloride 0 0 0 0 0 0 0 C30399849 30399-84-9 Isooctadecanoic acid 0 0 0 0 0 0 0 C30516871 30516-87-1 3'-Azido-3'-deoxythymidine 0 0 0 0 0 0 0 C3056175 3056-17-5 Stavudine 0 0 0 0 0 0 0 C307244 307-24-4 PFHxA 0 0 0 0 0 0 0 C311455 311-45-5 Paraoxon 0 0 0 0 0 0 0 C31218834 31218-83-4 Propetamphos 0 0 0 0 0 0 0 C313994795 313994-79-5 MK-578 0 0 0 0 0 0 0 C3194556 3194-55-6 1,2,5,6,9,10-Hexabromocyclododecane 0 0 0 0 0 0 0 C3268493 3268-49-3 3-(Methylthio)propanal 0 0 0 0 0 0 0 C32809168 32809-16-8 Procymidone 0 0 0 0 0 0 0 C328847 328-84-7 1,2-Dichloro-4-(trifluoromethyl)benzene 0 0 0 0 0 0 0 C3296900 3296-90-0 2,2-Bis(bromomethyl)-1,3-propanediol 0 0 0 0 0 0 0 C330198919 330198-91-9 Fully acetylated glycerol monoester on 12-Hydroxystearic acid (85%); Fully acetylated glycerol monostearate represents (10%) 0 0 0 0 0 0 0 C331623064 331623-06-4 MK-547 0 0 0 0 0 0 0 C3337711 3337-71-1 Asulam 0 0 0 0 0 0 0 C33703081 33703-08-1 Hexanedioic acid, diisononyl ester 0 0 0 0 0 0 0 C349495427 349495-42-7 PharmaGSID_47263 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 37**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C353280076 353280-07-6 CP-612372 0 0 0 0 0 0 0 C3547339 3547-33-9 2-Hydroxyethyl octyl sulfide 0 0 0 0 0 0 0 C35575963 35575-96-3 Azamethiphos 0 0 0 0 0 0 0 C3622842 3622-84-2 N-Butylbenzenesulfonamide 0 0 0 0 0 0 0 C36631308 36631-30-8 Triisodecyl trimellitate 0 0 0 0 0 0 0 C368832422 368832-42-2 CP-728663 0 0 0 0 0 0 0 C3734676 3734-67-6 C.I. Acid Red 1 0 0 0 0 0 0 0 C3739386 3739-38-6 3-Phenoxybenzoic acid 0 0 0 0 0 0 0 C375859 375-85-9 Perfluoroheptanoic acid 0 0 0 0 0 0 0 C3811049 3811-04-9 Potassium chlorate 0 0 0 0 0 0 0 C3825261 3825-26-1 PFOA, ammonium salt 0 0 0 0 0 0 0 C3871996 3871-99-6 PFHS-K 0 0 0 0 0 0 0 C3913028 3913-02-8 2-Butyloctan-1-ol 0 0 0 0 0 0 0 C3926623 3926-62-3 Sodium chloroacetate 0 0 0 0 0 0 0 C402910274 402910-27-4 UK-416244 0 0 0 0 0 0 0 C4065456 4065-45-6 Sulisobenzone 0 0 0 0 0 0 0 C4098719 4098-71-9 Isophorone diisocyanate 0 0 0 0 0 0 0 C4107986 4107-98-6 N,N-Diisopropylaniline 0 0 0 0 0 0 0 C4130421 4130-42-1 2,6-Di-tert-butyl-4-ethylphenol 0 0 0 0 0 0 0 C41372081 41372-08-1 Methyldopa sesquihydrate 0 0 0 0 0 0 0 C4151502 4151-50-2 Sulfluramid 0 0 0 0 0 0 0 C4376185 4376-18-5 Monomethyl phthalate 0 0 0 0 0 0 0 C4376209 4376-20-9 Mono(2-ethylhexyl) phthalate 0 0 0 0 0 0 0 C439687691 439687-69-1 Nelivaptan 0 0 0 0 0 0 0 C4418262 4418-26-2 Sodium dehydroacetate 0 0 0 0 0 0 0 C4437858 4437-85-8 Butylene carbonate 0 0 0 0 0 0 0 C4449518 4449-51-8 Cyclopamine 0 0 0 0 0 0 0 C445295045 445295-04-5 CP-671305 0 0 0 0 0 0 0 C4468422 4468-42-2 3-Phenylhexane 0 0 0 0 0 0 0 C446866 446-86-6 Azathioprine 0 0 0 0 0 0 0 C4548532 4548-53-2 FD&C Red 4 0 0 0 0 0 0 0 C4553622 4553-62-2 2-Methylpentanedinitrile 0 0 0 0 0 0 0 C460004 460-00-4 1-Bromo-4-fluorobenzene 0 0 0 0 0 0 0 C461023632 461023-63-2 Aplaviroc hydrochloride 0 0 0 0 0 0 0 C461585 461-58-5 Cyanoguanidine 0 0 0 0 0 0 0 C473289622 473289-62-2 Ilepatril 0 0 0 0 0 0 0 C478149530 478149-53-0 PHA-00543613 0 0 0 0 0 0 0 C480637 480-63-7 2,4,6-Trimethylbenzoic acid 0 0 0 0 0 0 0 C486566 486-56-6 Cotinine 0 0 0 0 0 0 0 C487069 487-06-9 5,7-Dimethoxy-2H-chromen-2-one 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 38**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C4904614 4904-61-4 1,5,9-Cyclododecatriene 0 0 0 0 0 0 0 C493527 493-52-7 Methyl red 0 0 0 0 0 0 0 C4940118 4940-11-8 2-Ethyl-3-hydroxy-4H-pyran-4-one 0 0 0 0 0 0 0 C501027492 501027-49-2 PD-0333941 0 0 0 0 0 0 0 C50351 50-35-1 Thalidomide 0 0 0 0 0 0 0 C50555 50-55-5 Reserpine 0 0 0 0 0 0 0 C50594666 50594-66-6 Acifluorfen 0 0 0 0 0 0 0 C50782 50-78-2 Aspirin 0 0 0 0 0 0 0 C50892234 50892-23-4 Pirinixic acid 0 0 0 0 0 0 0 C510156 510-15-6 Chlorobenzilate 0 0 0 0 0 0 0 C51058 51-05-8 Procaine hydrochloride 0 0 0 0 0 0 0 C51218 51-21-8 5-Fluorouracil 0 0 0 0 0 0 0 C512425 512-42-5 Sodium methyl sulfate 0 0 0 0 0 0 0 C512561 512-56-1 Trimethyl phosphate 0 0 0 0 0 0 0 C51285 51-28-5 2,4-Dinitrophenol 0 0 0 0 0 0 0 C51309 51-30-9 Isoproterenol hydrochloride 0 0 0 0 0 0 0 C5138181 5138-18-1 Sulfosuccinic acid 0 0 0 0 0 0 0 C5146667 5146-66-7 2,6-Octadienenitrile, 3,7-dimethyl- 0 0 0 0 0 0 0 C520456 520-45-6 Dehydroacetic acid 0 0 0 0 0 0 0 C5216251 5216-25-1 4-Chlorobenzotrichloride 0 0 0 0 0 0 0 C527680564 527680-56-4 PHA-00568487 0 0 0 0 0 0 0 C52806538 52806-53-8 Hydroxyflutamide 0 0 0 0 0 0 0 C528290 528-29-0 1,2-Dinitrobenzene 0 0 0 0 0 0 0 C532025 532-02-5 Sodium 2-naphthalenesulfonate 0 0 0 0 0 0 0 C5329146 5329-14-6 Sulfamic acid 0 0 0 0 0 0 0 C533233 533-23-3 2,4-D-ethyl ester 0 0 0 0 0 0 0 C5333426 5333-42-6 2-Octy l-1-dodecanol 0 0 0 0 0 0 0 C534134 534-13-4 N,N'-Dimethylthiourea 0 0 0 0 0 0 0 C53703 53-70-3 Dibenz(a,h)anthracene 0 0 0 0 0 0 0 C53861 53-86-1 Indomethacin 0 0 0 0 0 0 0 C53894238 53894-23-8 Triisononyl trimellitate 0 0 0 0 0 0 0 C5394365 5394-36-5 5-Ethyl-5-methylhydantoin 0 0 0 0 0 0 0 C5407987 5407-98-7 Cyclobutyl phenyl ketone 0 0 0 0 0 0 0 C540885 540-88-5 tert-Buty l acetate 0 0 0 0 0 0 0 C541026 541-02-6 Decamethylcyclopentasiloxane 0 0 0 0 0 0 0 C54115 54-11-5 Nicotine 0 0 0 0 0 0 0 C541731 541-73-1 1,3-Dichlorobenzene 0 0 0 0 0 0 0 C542927 542-92-7 1,3-Cyclopentadiene 0 0 0 0 0 0 0 C54626 54-62-6 4-Aminofolic acid 0 0 0 0 0 0 0 C54853 54-85-3 Isoniazid 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 39**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C550447 550-44-7 N-Methylphthalimide 0 0 0 0 0 0 0 C55185 55-18-5 N-Nitrosodiethylamine 0 0 0 0 0 0 0 C55290647 55290-64-7 Dimethipin 0 0 0 0 0 0 0 C553264 553-26-4 4,4'-Bipyridine 0 0 0 0 0 0 0 C553708 553-70-8 Magnesium dibenzoate 0 0 0 0 0 0 0 C55512339 55512-33-9 Pyridate 0 0 0 0 0 0 0 C55589623 55589-62-3 Acesulfame potassium 0 0 0 0 0 0 0 C556525 556-52-5 Glycidol 0 0 0 0 0 0 0 C55814410 55814-41-0 Mepronil 0 0 0 0 0 0 0 C55934935 55934-93-5 Tripropylene glycol butyl ether 0 0 0 0 0 0 0 C55981 55-98-1 Busulfan 0 0 0 0 0 0 0 C56042 56-04-2 6-Methyl-2-thiouracil 0 0 0 0 0 0 0 C56375792 56375-79-2 N,N-Dibutyl-N-methylbutan-1-aminium chloride 0 0 0 0 0 0 0 C56382 56-38-2 Parathion 0 0 0 0 0 0 0 C5700492 5700-49-2 1,2-Ethanediamine dihydriodide 0 0 0 0 0 0 0 C57147 57-14-7 1,1-Dimethylhydrazine 0 0 0 0 0 0 0 C57307 57-30-7 Phenobarbital sodium 0 0 0 0 0 0 0 C57410 57-41-0 5,5-Diphenylhydantoin 0 0 0 0 0 0 0 C579668 579-66-8 2,6-Diethylaniline 0 0 0 0 0 0 0 C58082 58-08-2 Caffeine 0 0 0 0 0 0 0 C58140 58-14-0 Pyrimethamine 0 0 0 0 0 0 0 C583788 583-78-8 2,5-Dichlorophenol 0 0 0 0 0 0 0 C58394642 58394-64-2 Benzyloctyl adipate 0 0 0 0 0 0 0 C584849 584-84-9 Toluene-2,4-diisocyanate 0 0 0 0 0 0 0 C5850862 5850-86-2 C.I. Acid Orange 8, monosodium salt 0 0 0 0 0 0 0 C58559 58-55-9 Theophylline 0 0 0 0 0 0 0 C587859 587-85-9 Diphenylmercury(II) 0 0 0 0 0 0 0 C58855 58-85-5 Biotin 0 0 0 0 0 0 0 C58866 58-86-6 D-Xylose 0 0 0 0 0 0 0 C58935 58-93-5 Hydrochlorothiazide 0 0 0 0 0 0 0 C59052 59-05-2 Methotrexate 0 0 0 0 0 0 0 C59227893 59227-89-3 Laurocapram 0 0 0 0 0 0 0 C59405 59-40-5 Sulfaquinoxaline 0 0 0 0 0 0 0 C594207 594-20-7 2,2-Dichloropropane 0 0 0 0 0 0 0 C59676 59-67-6 Nicotinic acid 0 0 0 0 0 0 0 C598550 598-55-0 Methyl carbamate 0 0 0 0 0 0 0 C59870 59-87-0 Nitrofurazone 0 0 0 0 0 0 0 C599791 599-79-1 Sulfasalazine 0 0 0 0 0 0 0 C60548 60-54-8 Tetracycline 0 0 0 0 0 0 0 C60560 60-56-0 Methimazole 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 40**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C606202 606-20-2 2,6-Dinitrotoluene 0 0 0 0 0 0 0 C611201 611-20-1 Benzonitrile, 2-hydroxy- 0 0 0 0 0 0 0 C614459 614-45-9 tert-Buty l perbenzoate 0 0 0 0 0 0 0 C6149037 6149-03-7 Sodium 4-octylbenzenesulfonate 0 0 0 0 0 0 0 C6153646 6153-64-6 Oxy tetracycline dihydrate 0 0 0 0 0 0 0 C616455 616-45-5 2-Pyrrolidinone 0 0 0 0 0 0 0 C61825 61-82-5 Amitrole 0 0 0 0 0 0 0 C6190654 6190-65-4 Deethylatrazine 0 0 0 0 0 0 0 C621647 621-64-7 N-Nitrosodipropylamine 0 0 0 0 0 0 0 C62237 62-23-7 4-Nitrobenzoic acid 0 0 0 0 0 0 0 C622979 622-97-9 4-Methylstyrene 0 0 0 0 0 0 0 C625558 625-55-8 Isopropyl formate 0 0 0 0 0 0 0 C62566 62-56-6 Thiourea 0 0 0 0 0 0 0 C626437 626-43-7 3,5-Dichloroaniline 0 0 0 0 0 0 0 C6285058 6285-05-8 Ethyl 4-chlorophenyl ketone 0 0 0 0 0 0 0 C629765 629-76-5 1-Pentadecanol 0 0 0 0 0 0 0 C633965 633-96-5 C.I. Acid Orange 7 0 0 0 0 0 0 0 C6359826 6359-82-6 Acid Yellow 11 0 0 0 0 0 0 0 C6359906 6359-90-6 C.I. Acid Yellow 34, monosodium salt 0 0 0 0 0 0 0 C6359984 6359-98-4 C.I. Acid Yellow 17, disodium salt 0 0 0 0 0 0 0 C63612500 63612-50-0 Nilutamide 0 0 0 0 0 0 0 C636215 636-21-5 2-Methylaniline hydrochloride 0 0 0 0 0 0 0 C637070 637-07-0 Clofibrate 0 0 0 0 0 0 0 C6381777 6381-77-7 Sodium erythorbate (1:1) 0 0 0 0 0 0 0 C64108 64-10-8 Urea, phenyl- 0 0 0 0 0 0 0 C6422862 6422-86-2 Bis(2-ethylhexyl) terephthalate 0 0 0 0 0 0 0 C643798 643-79-8 1,2-Benzenedicarboxaldehyde 0 0 0 0 0 0 0 C644973 644-97-3 Phenyl phosphorus dichloride 0 0 0 0 0 0 0 C645625 645-62-5 2-Ethyl-2-hexenal 0 0 0 0 0 0 0 C64675 64-67-5 Diethyl sulfate 0 0 0 0 0 0 0 C64868 64-86-8 Colchicine 0 0 0 0 0 0 0 C648917139 648917-13-9 AVE2865 0 0 0 0 0 0 0 C65452 65-45-2 Salicylamide 0 0 0 0 0 0 0 C6610293 6610-29-3 N-Methylhydrazinecarbothioamide 0 0 0 0 0 0 0 C6624733 6624-73-3 Pentane-1,5-diyl dibenzoate 0 0 0 0 0 0 0 C6625463 6625-46-3 C.I. Acid Violet 12, disodium salt 0 0 0 0 0 0 0 C66273 66-27-3 Methyl methanesulfonate 0 0 0 0 0 0 0 C66357355 66357-35-5 Ranitidine 0 0 0 0 0 0 0 C66456539 66456-53-9 Adipic acid, polypropyleneglycol, laurate 0 0 0 0 0 0 0 C6734801 6734-80-1 Metam-sodium hydrate 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 41**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C67747095 67747-09-5 Prochloraz 0 0 0 0 0 0 0 C67786145 67786-14-5 Acid Red 337 0 0 0 0 0 0 0 C68111 68-11-1 Thioglycolic acid 0 0 0 0 0 0 0 C68122 68-12-2 N,N-Dimethylformamide 0 0 0 0 0 0 0 C68169039 68169-03-9 2-(Dihydrocyclopentadienyloxy)ethyl methacrylate 0 0 0 0 0 0 0 C682019 682-01-9 Tetrapropyl orthosilicate 0 0 0 0 0 0 0 C68515480 68515-48-0 DINP branched 0 0 0 0 0 0 0 C68515491 68515-49-1 1,2-Benzenedicarboxylic acid, di-C9-11-branched alkyl esters, C10-rich 0 0 0 0 0 0 0 C68515753 68515-75-3 Hexanedioic acid, di-C7-9-branched and linear alkyl esters 0 0 0 0 0 0 0 C68555862 68555-86-2 Acid Orange 156 0 0 0 0 0 0 0 C68609972 68609-97-2 C12-14-Alkyl glycidyl ether 0 0 0 0 0 0 0 C69090 69-09-0 Chlorpromazine hydrochloride 0 0 0 0 0 0 0 C6915157 6915-15-7 Malic acid 0 0 0 0 0 0 0 C6923224 6923-22-4 Monocrotophos 0 0 0 0 0 0 0 C69655056 69655-05-6 2',3'-Dideoxyinosine 0 0 0 0 0 0 0 C69658 69-65-8 D-Mannitol 0 0 0 0 0 0 0 C69806504 69806-50-4 Fluazifop-butyl 0 0 0 0 0 0 0 C70553 70-55-3 4-Toluenesulfonamide 0 0 0 0 0 0 0 C70568604 70568-60-4 4-Butylcyclohexanol 0 0 0 0 0 0 0 C7080504 7080-50-4 Chloramine-T trihydrate 0 0 0 0 0 0 0 C717748 717-74-8 1,3,5-Triisopropylbenzene 0 0 0 0 0 0 0 C72208 72-20-8 Endrin 0 0 0 0 0 0 0 C732263 732-26-3 2,4,6-Tris(tert-butyl)phenol 0 0 0 0 0 0 0 C73314 73-31-4 Melatonin 0 0 0 0 0 0 0 C7378996 7378-99-6 N,N-Dimethyloctylamine 0 0 0 0 0 0 0 C7398698 7398-69-8 Dimethyldiallylammonium chloride 0 0 0 0 0 0 0 C742693385 742693-38-5 SSR504734 0 0 0 0 0 0 0 C753731 753-73-1 Dimethyltin dichloride 0 0 0 0 0 0 0 C75605 75-60-5 Dimethylarsinic acid 0 0 0 0 0 0 0 C75649 75-64-9 tert-Buty lamine 0 0 0 0 0 0 0 C756796 756-79-6 Dimethyl methylphosphonate 0 0 0 0 0 0 0 C75990 75-99-0 Dalapon 0 0 0 0 0 0 0 C760236 760-23-6 3,4-Dichloro-1-butene 0 0 0 0 0 0 0 C76039 76-03-9 Trichloroacetic acid 0 0 0 0 0 0 0 C762049 762-04-9 Diethyl phosphite 0 0 0 0 0 0 0 C76448 76-44-8 Heptachlor 0 0 0 0 0 0 0 C7659861 7659-86-1 2-Ethylhexyl sulfanylacetate 0 0 0 0 0 0 0 C7681767 7681-76-7 Ronidazole 0 0 0 0 0 0 0 C770354 770-35-4 1-Phenoxy-2-propanol 0 0 0 0 0 0 0 C7747355 7747-35-5 5-Ethyl-1-aza-3,7-dioxabicyclo[3.3.0]octane 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 42**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C77714 77-71-4 5,5-Dimethylhydantoin 0 0 0 0 0 0 0 C77736 77-73-6 Dicyclopentadiene 0 0 0 0 0 0 0 C7775271 7775-27-1 Sodium persulfate 0 0 0 0 0 0 0 C77781 77-78-1 Dimethyl sulfate 0 0 0 0 0 0 0 C7779273 7779-27-3 1,3,5-Triethylhexahydro-s-triazine 0 0 0 0 0 0 0 C77861 77-86-1 Tromethamine 0 0 0 0 0 0 0 C7786347 7786-34-7 Mevinphos 0 0 0 0 0 0 0 C78079 78-07-9 Ethyltriethoxysilane 0 0 0 0 0 0 0 C78115 78-11-5 Pentaerythritol tetranitrate 0 0 0 0 0 0 0 C78491028 78491-02-8 Diazolidinyl urea 0 0 0 0 0 0 0 C78820 78-82-0 2-Methylpropanenitrile 0 0 0 0 0 0 0 C78966 78-96-6 1-Amino-2-propanol 0 0 0 0 0 0 0 C79098207 79098-20-7 4-Chloropentylbenzene 0 0 0 0 0 0 0 C79163 79-16-3 N-Methylacetamide 0 0 0 0 0 0 0 C79243 79-24-3 Nitroethane 0 0 0 0 0 0 0 C79390 79-39-0 Methacrylamide 0 0 0 0 0 0 0 C79436 79-43-6 Dichloroacetic acid 0 0 0 0 0 0 0 C79447 79-44-7 Dimethylcarbamoyl chloride 0 0 0 0 0 0 0 C79572 79-57-2 Oxy tetracycline 0 0 0 0 0 0 0 C8004920 8004-92-0 C.I. Acid Yellow 3 disodium salt 0 0 0 0 0 0 0 C80079 80-07-9 4,4'-Dichlorodiphenyl sulfone 0 0 0 0 0 0 0 C80159 80-15-9 Cumene hydroperoxide 0 0 0 0 0 0 0 C81072 81-07-2 Saccharin 0 0 0 0 0 0 0 C81131706 81131-70-6 Pravastatin sodium 0 0 0 0 0 0 0 C81405858 81405-85-8 Imazmethabenz 0 0 0 0 0 0 0 C818611 818-61-1 2-Hydroxyethyl acrylate 0 0 0 0 0 0 0 C81889 81-88-9 Rhodamine B 0 0 0 0 0 0 0 C822060 822-06-0 1,6-Diisocyanatohexane 0 0 0 0 0 0 0 C82469792 82469-79-2 Butyryl trihexyl citrate 0 0 0 0 0 0 0 C826620 826-62-0 3a,4,7,7a-Tetrahydro-4,7-methanoisobenzofuran-1,3-dione 0 0 0 0 0 0 0 C83329 83-32-9 Acenaphthene 0 0 0 0 0 0 0 C83410 83-41-0 1,2-Dimethyl-3-nitrobenzene 0 0 0 0 0 0 0 C83670 83-67-0 Theobromine 0 0 0 0 0 0 0 C83834597 83834-59-7 2-Ethylhexyl trans-4-methoxycinnamate 0 0 0 0 0 0 0 C83885 83-88-5 Riboflavin 0 0 0 0 0 0 0 C838857 838-85-7 Diphenyl phosphate 0 0 0 0 0 0 0 C85018 85-01-8 Phenanthrene 0 0 0 0 0 0 0 C851916422 851916-42-2 MK-812 0 0 0 0 0 0 0 C85405 85-40-5 1,2,3,6-Tetrahydrophthalimide 0 0 0 0 0 0 0 C85416 85-41-6 Phthalimide 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 43**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C85507795 85507-79-5 Phthalic acid, diundecyl ester, branched and linear 0 0 0 0 0 0 0 C85532758 85532-75-8 PK 11195 0 0 0 0 0 0 0 C860220 860-22-0 C.I. Acid Blue 74 0 0 0 0 0 0 0 C862243296 862243-29-6 AVE9423 0 0 0 0 0 0 0 C86386734 86386-73-4 Fluconazole 0 0 0 0 0 0 0 C864283487 864283-48-7 GSK232420A 0 0 0 0 0 0 0 C86500 86-50-0 Azinphos-methyl 0 0 0 0 0 0 0 C86737 86-73-7 Fluorene 0 0 0 0 0 0 0 C87014 87-01-4 7-(Dimethylamino)-4-methylcoumarin 0 0 0 0 0 0 0 C87616 87-61-6 1,2,3-Trichlorobenzene 0 0 0 0 0 0 0 C87627 87-62-7 2,6-Dimethylaniline 0 0 0 0 0 0 0 C87683 87-68-3 Hexachloro-1,3-butadiene 0 0 0 0 0 0 0 C877247 877-24-7 Monopotassium phthalate 0 0 0 0 0 0 0 C87820880 87820-88-0 Tralkoxydim 0 0 0 0 0 0 0 C88062 88-06-2 2,4,6-Trichlorophenol 0 0 0 0 0 0 0 C88120 88-12-0 N-Vinyl-2-pyrrolidone 0 0 0 0 0 0 0 C88722 88-72-2 2-Nitrotoluene 0 0 0 0 0 0 0 C88744 88-74-4 2-Nitroaniline 0 0 0 0 0 0 0 C89043 89-04-3 Trioctyl trimellitate 0 0 0 0 0 0 0 C89714 89-71-4 Methyl 2-methylbenzoate 0 0 0 0 0 0 0 C9003116 9003-11-6 Pluronic F-127 0 0 0 0 0 0 0 C90040 90-04-0 2-Anisidine 0 0 0 0 0 0 0 C9016879 9016-87-9 Isocyanic acid, polymethylenepolyphenylene ester 0 0 0 0 0 0 0 C90722 90-72-2 2,4,6-Tris(dimethylaminomethyl)phenol 0 0 0 0 0 0 0 C91082176 91082-17-6 C10-21 sulfonic acids phenyl esters 0 0 0 0 0 0 0 C91598 91-59-8 2-Naphthylamine 0 0 0 0 0 0 0 C91667 91-66-7 N,N-Diethylaniline 0 0 0 0 0 0 0 C919302 919-30-2 3-Aminopropyltriethoxysilane 0 0 0 0 0 0 0 C924163 924-16-3 N-Nitrosodibutylamine 0 0 0 0 0 0 0 C929601092 929601-09-2 SR58611 0 0 0 0 0 0 0 C93561 93-56-1 Sty rene glycol 0 0 0 0 0 0 0 C93765 93-76-5 2,4,5-Trichlorophenoxyacetic acid 0 0 0 0 0 0 0 C938169 938-16-9 tert-Buty l phenyl ketone 0 0 0 0 0 0 0 C93992 93-99-2 Phenyl benzoate 0 0 0 0 0 0 0 C94086 94-08-6 Ethyl 4-methylbenzoate 0 0 0 0 0 0 0 C94280 94-28-0 Triethylene glycol bis(2-ethylhexanoate) 0 0 0 0 0 0 0 C94597 94-59-7 Safrole 0 0 0 0 0 0 0 C94600 94-60-0 Dimethyl hexahydroterephthalate 0 0 0 0 0 0 0 C94713 94-71-3 2-Ethoxyphenol 0 0 0 0 0 0 0 C94804 94-80-4 2,4-D 1-butyl ester 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 44**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

C94917 94-91-7 N,N'-Disalicylidene-1,2-diaminopropane 0 0 0 0 0 0 0 C94962 94-96-2 2-Ethyl-1,3-hexanediol 0 0 0 0 0 0 0 C95147 95-14-7 1,2,3-Benzotriazole 0 0 0 0 0 0 0 C95487 95-48-7 o-Cresol 0 0 0 0 0 0 0 C95498 95-49-8 2-Chlorotoluene 0 0 0 0 0 0 0 C95545 95-54-5 1,2-Phenylenediamine 0 0 0 0 0 0 0 C95578 95-57-8 2-Chlorophenol 0 0 0 0 0 0 0 C957517 957-51-7 Diphenamid 0 0 0 0 0 0 0 C95807 95-80-7 2,4-Diaminotoluene 0 0 0 0 0 0 0 C95830 95-83-0 4-Chloro-1,2-diaminobenzene 0 0 0 0 0 0 0 C95932 95-93-2 1,2,4,5-Tetramethylbenzene 0 0 0 0 0 0 0 C95943 95-94-3 1,2,4,5-Tetrachlorobenzene 0 0 0 0 0 0 0 C96093 96-09-3 Sty rene oxide 0 0 0 0 0 0 0 C96231 96-23-1 1,3-Dichloro-2-propanol 0 0 0 0 0 0 0 C962583 962-58-3 Diazoxon 0 0 0 0 0 0 0 C96297 96-29-7 2-Butanone oxime 0 0 0 0 0 0 0 C96413 96-41-3 Cyclopentanol 0 0 0 0 0 0 0 C96764 96-76-4 2,4-Di-tert-butylphenol 0 0 0 0 0 0 0 C97529 97-52-9 2-Methoxy-4-nitroaniline 0 0 0 0 0 0 0 C97596 97-59-6 Allantoin 0 0 0 0 0 0 0 C97778 97-77-8 Disulfiram 0 0 0 0 0 0 0 C98000 98-00-0 Furfuryl alcohol 0 0 0 0 0 0 0 C98066 98-06-6 tert-Buty lbenzene 0 0 0 0 0 0 0 C98077 98-07-7 Benzotrichloride 0 0 0 0 0 0 0 C98319267 98319-26-7 Finasteride 0 0 0 0 0 0 0 C98566 98-56-6 1-Chloro-4-(trifluoromethyl)benzene 0 0 0 0 0 0 0 C98873 98-87-3 Benzal chloride 0 0 0 0 0 0 0 C99081 99-08-1 3-Nitrotoluene 0 0 0 0 0 0 0 C99514 99-51-4 1,2-Dimethyl-4-nitrobenzene 0 0 0 0 0 0 0 C99547 99-54-7 3,4-Dichloronitrobenzene 0 0 0 0 0 0 0 C99558 99-55-8 2-Methyl-5-nitroaniline 0 0 0 0 0 0 0 C99592 99-59-2 2-Methoxy-5-nitroaniline 0 0 0 0 0 0 0 C99627 99-62-7 1,3-Diisopropylbenzene 0 0 0 0 0 0 0 C99638 99-63-8 1,3-Benzenedicarbonyl dichloride 0 0 0 0 0 0 0 C99661 99-66-1 Valproic acid 0 0 0 0 0 0 0 C99934 99-93-4 4-Hydroxyacetophenone 0 0 0 0 0 0 0 C99967 99-96-7 4-Hydroxybenzoic acid 0 0 0 0 0 0 0 C99990 99-99-0 4-Nitrotoluene 0 0 0 0 0 0 0 C999973 999-97-3 Hexamethyldisilazane 0 0 0 0 0 0 0 CNOCAS47248 NOCAS_47248 CI-1018 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 45**U.S. EPA Endocrine Disruptor Screening Program (EDSP) Estrogen Receptor Bioactiv**  **ity Based on ToxCast TM**  **“ER Model” EDSP ER Model Bioactivity 01June2015.xlsx** **E P** **A A** **C T** **o R** **C o** **d e** **C A** **S R** **e g** **i s** **t r** **y N** **u m** **b e** **r**

**Chemical Name L** **i s** **t 1** **L i** **s t** **2 P** **e s** **t i** **c i** **d e** **A c** **t i** **v e** **I n** **g r** **e d** **i e** **n t** **P e** **s t** **i c** **i d** **e I** **n e** **r t** **E R** **A g** **o n** **i s** **t A** **U C** **E R** **A n** **t a** **g o** **n i** **s t** **A U** **C E** **R B** **i o** **a c** **t i** **v i** **t y** 

CNOCAS47255 NOCAS_47255 CP-465394 0 0 0 0 0 0 0 CNOCAS47265 NOCAS_47265 CP-471358 0 0 0 0 0 0 0 CNOCAS47267 NOCAS_47267 CP-642931 0 0 0 0 0 0 0 CNOCAS47291 NOCAS_47291 CI-1044 0 0 0 0 0 0 0 CNOCAS47292 NOCAS_47292 PD 0200347 0 0 0 0 0 0 0 CNOCAS47299 NOCAS_47299 CP-422935 0 0 0 0 0 0 0 CNOCAS47305 NOCAS_47305 CP-608039 0 0 0 0 0 0 0 CNOCAS47328 NOCAS_47328 MK-274 0 0 0 0 0 0 0 CNOCAS47330 NOCAS_47330 PharmaGSID_47330 0 0 0 0 0 0 0 CNOCAS47333 NOCAS_47333 PharmaGSID_47333 0 0 0 0 0 0 0 CNOCAS47342 NOCAS_47342 SR125047 0 0 0 0 0 0 0 CNOCAS47362 NOCAS_47362 SSR150106 0 0 0 0 0 0 0 CNOCAS47366 NOCAS_47366 SAR115740 0 0 0 0 0 0 0 CNOCAS47383 NOCAS_47383 AVE3247 0 0 0 0 0 0 0 CNOCAS47385 NOCAS_47385 SAR377142 0 0 0 0 0 0 0 CNOCAS47796 NOCAS_47796 Formalin 0 0 0 0 0 0 0

AUC - Area Under the Curve ; ER - Estrogen Receptor ; 1* - List 1 chemicals w ithdraw n from pesticide market (http://w ww. epa.gov/endo/pubs/edsp_orders_status.pdf) Page 46