34446 Federal Register / Vol. 65, No. 104 / Tuesday, May 30, 2000 / Notices

CONSUMER PRODUCT SAFETY

COMMISSION

Notice of Meeting of Chronic Hazard

Advisory Panel on Diisononyl

Phthalate (DINP) and Opportunity for

Public Comment

AGENCY: Consumer Product Safety

Commission.

ACTION: Notice of meeting.

SUMMARY: The Commission announces

the second meeting of the Chronic

Hazard Advisory Panel (CHAP) on

diisononyl phthalate (DINP). The

Commission appointed this CHAP to

advise the Commission on any chronic

hazards of cancer, birth defects, and

gene mutations associated with

children’s products containing DINP.

The public may submit written or oral

comments on the issues to be

considered by the CHAP.

DATES: The opportunity for the

presentation of oral comments will be

on June 20 from 10 a.m. to 5 p.m. The

remainder of the meeting will be held

from 8:30 a.m. to 5 p.m. on June 21 and

from 8:30 a.m. to 4 p.m. on June 22,

2000.

Requests to present oral comments,

and a written copy of the text of the oral

comments, must be filed with the Office

of the Secretary no later than June 13,

2000.

Written comments must be received

no later than June 13, 2000.

ADDRESSES: The meeting will be held in

the fourth floor hearing room in the

Commission’s offices at 4330 East-West

Highway, Bethesda, Maryland.

Written comments, or requests to

present oral comments and the written

text of such comments, should be

mailed, preferably in five copies, to the

Office of the Secretary, Consumer

Product Safety Commission,

Washington, D.C. 20207–0001, or

delivered to the Office of the Secretary,

Consumer Product Safety Commission,

Room 502, 4330 East-West Highway,

Bethesda, Maryland; telephone (301)

504–0800. These items also may be filed

by telefacsimile to (301)504–0127 or by

email to cpsc-os@cpsc.gov. These items

should be captioned ‘‘CHAP on DINP.’’

FOR FURTHER INFORMATION CONTACT:

Concerning requests and procedures for

oral presentations of comments:

Rockelle Hammond, Docket Control and

Communications Specialist, Consumer

Product Safety Commission,

Washington, DC 20207; telephone: (301)

504–0800 ext. 1232; email cpscos@cpsc.gov. For all other matters:

Marilyn Wind, Directorate for Health

Sciences, Consumer Product Safety

Commission, Washington, D.C. 20207;

telephone (301) 504–0477, ext. 1205;

email mwind@cpsc.gov.

SUPPLEMENTARY INFORMATION: The

Commission has been concerned with

potential risks posed to children under

3 years of age by the plasticizer

diisononyl phthalate (DINP), which is

used to soften some children’s teethers,

rattles, and toys made from polyvinyl

chloride (PVC). DINP can leach from

such products when they are mouthed

or held by children, causing some DINP

to be absorbed through skin and mucous

membranes. DINP has been shown to

cause liver and other organ toxicity in

laboratory animals. Also, the

Commission has received a petition (No.

HP 99–1) from the National

Environmental Trust and eleven other

organizations asking that the

Commission ban PVC in children’s

products.

The Commission appointed a sevenmember CHAP to evaluate the existing

scientific information regarding the

mechanism by which DINP may cause

cancer and the implications of this on

the potential cancer risk to children.

The CHAP members were selected from

scientists recommended by the National

Academy of Sciences. See 15 U.S.C.

2077, 2030(b). The first meeting of the

CHAP was on May 10–11, 2000. The

second meeting of the CHAP will be on

June 20–22, 2000, in the fourth floor

hearing room at the Commission’s

offices in Bethesda, MD (see address

above).

The CHAP is seeking public comment

on issues relating to the hazard,

exposure, and risk posed by DINP in

children’s products. It is interested in

comments and data pertaining to: (a)

What the appropriate Acceptable Daily

Intake (ADI) of DINP would be; (b)

which critical endpoint to use to

determine the ADI; (c) the mechanism

by which DINP causes cancer in rodents

and the relevance of these induced

neoplasms to human risk; (d) the

appropriate risk assessment model or

models to determine human risk; (e) the

differential sensitivity/susceptibility of

young children to the effects of DINP, if

any, and how to incorporate that into an

assessment of risk; and (f) agedependent pharmacokinetic differences.

In addition, it is particularly interested

in the following:

1. Are Diisononyl Phthalate (DINP)

rodent cancer bioassay data inapplicable

to human hazard identification?

2. Is there convincing evidence that a

linear extrapolation approach for risk

assessment is not appropriate for DINP?

3. What is the most appropriate

measure of the biologically effective

dose for DINP-induced liver cancer?

4. Any data available on the

percutaneous absorption of DINP.

(Provide any data available on

absorption of DINP from the oral

mucosa.)

5. Any available data on the

pharmacokinetics of DINP including

salivary metabolism.

6. Any available data on DINP

metabolites.

7. Any available information on

spongiosis hepatis.

8. Total exposure to phthalates in

adults and children.

9. Toxicological interactions between

phthalate esters.

The CPSC would appreciate it if any

suitable data are submitted in the form

of an Excel Spread Sheet, a space

delimited ASCII file, or a SAS (SD2 or

SSD) dataset.

There will be an opportunity for oral

comments on June 20, from 10 am to 5

pm. As explained at the beginning of

this notice, persons wishing to present

oral comments must file a request, and

a written copy of the text of their

comments, with the Commission’s

Office of the Secretary no later than June

13, 2000.

Commenters should limit their

presentations to approximately 15

minutes, exclusive of any periods of

questioning by the members of the

CHAP or the CPSC staff. The CHAP

reserves the right to further limit the

time for any presentation and to impose

restrictions to avoid excessive

duplication of presentations.

Interested persons may also file

written comments with the CHAP.

Written comments must be filed with

the Office of the Secretary no later than

June 13, 2000.

The remainder of the CHAP meeting

will be from 8:30 a.m. to 5 p.m. on June

21 and from 8:30 a.m. to 4 p.m. on June

22, 2000. During this part of the

meeting, the CHAP will discuss issues

and the report it will write.

Dated: May 24, 2000.

Sadye E. Dunn,

Secretary, Consumer Product Safety

Commission.

[FR Doc. 00–13466 Filed 5–26–00; 8:45 am]

BILLING CODE 6355–01–P

DEPARTMENT OF DEFENSE

Office of the Secretary

Renewal of the Board of Visitors for

the Department of Defense Regional

Security Centers

ACTION: Notice.

Federal Register / Vol. 65, No. 104 / Tuesday, May 30, 2000 / Notices 34447

SUMMARY: The Board of Visitors for the

Department of Defense Regional

Security Centers was renewed, effective

May 1, 2000, in consonance with the

public interest, and in accordance with

the provisions of Pub. L. 92–463, the

‘‘Federal Advisory Committee Act.’’

The Board of Visitors, comprised of a

balanced membership of leading experts

in the field of national security, is

essential in providing advice and

counsel to the Secretary of Defense,

other senior Pentagon officials, and

sound management of the DoD Regional

Security Centers. The Board members

are chosen for their experience and

knowledge of national security affairs,

academics, and regional politicalmilitary issues. They advise senior DoD

officials on matters relating to mission,

policy, course content, faculty, and

administration of the Centers.

FOR FURTHER INFORMATION CONTACT: John

Berry, Director, Regional Affairs (703)

695–6386.

Dated: May 23, 2000.

Linda M. Bynum,

Alternate OSD Federal Liaison Officer,

Department of Defense.

[FR Doc. 00–13407 Filed 5–26–00; 8:45 am]

BILLING CODE 5001–10–M

DEPARTMENT OF DEFENSE

Office of the Secretary

Revised Non-Foreign Overseas per

Diem Rates

AGENCY: DoD, Per Diem, Travel and

Transportation Allowance Committee.

ACTION: Notice of revised non-foreign

overseas per diem rates.

SUMMARY: The Per Diem, Travel and

Transportation Allowance Committee is

publishing Civilian Personnel Per Diem

Bulletin Number 217. This bulletin lists

revisions in the per diem rates

prescribed for U.S. Government

employees for official travel in Alaska,

Hawaii, Puerto Rico, the Northern

Mariana Islands and Possessions of the

United States. AEA changes announced

in Bulletin Number 194 remain in effect.

Bulletin Number 217 is being published

in the Federal Register to assure that

travelers are paid per diem at the most

current rates.

EFFECTIVE DATE: June 1, 2000.

SUPPLEMENTARY INFORMATION: This

document gives notice of revisions in

per diem rates prescribed by the Per

Diem Travel and Transportation

Allowance Committee for non-foreign

areas outside the continental United

States. It supersedes Civilian Personnel

Per Diem Bulletin Number 216.

Distribution of Civilian Personnel Per

Diem Bulletins by mail was

discontinued. Per Diem Bulletins

published periodically in the Federal

Register now constitute the only

notification of revisions in per diem

rates to agencies and establishments

outside the Department of Defense. For

more information or questions about per

diem rates, please contact your local

travel office. The text of the Bulletin

follows:

BILLING CODE 5001–10–M