35922 Federal Register / Vol. 78, No. 115 / Friday, June 14, 2013 / Notices 

Environmental Endocrine Disruptor 

Screening Program; Review of the 

Endocrine Disruptor Screening Program 

by a Joint Subcommittee of the Science 

Advisory Board and Scientific Advisory 

Panel. July 1999. EPA publication 

number EPA–SAB–EC–99–013. 

Available at http://www.epa.gov/endo/

pubs/sab_sap_report.pdf. 

15. EPA. U.S. Environmental Protection 

Agency Endocrine Disruptor Screening 

Program Comprehensive Management 

Plan. June 2012. Available at http://

www.epa.gov/endo/pubs/EDSPcomprehensive-management-plan.pdf. 

16. EPA. At a Glance: Issuing EDSP Second 

List Orders. (March 28, 2013). 

17. EPA. Chemical Data Reporting Web site 

at http://www.epa.gov/oppt/cdr. 

18. EPA. Status of EDSP Orders/DCIs as of 

Wednesday, January 2, 2013. 

19. EPA. Sample Form: ‘‘FFDCA § 408(p) 

Order for SDWA § 1457 Chemicals— 

Initial Response Form for Individual 

Order Recipients’’ (EPA Form No. 6300– 

06). March 27, 2013. Available in 

Attachment D(3) to the ICR in Docket ID 

Number EPA–HQ–OPPT–2013–0275. 

20. EPA. OCSPP Harmonized Test Guidelines 

Web site at http://www.epa.gov/ocspp/

pubs/frs/home/testmeth.htm. 

21. EPA. Sample Form: ‘‘FFDCA § 408(p) 

Order for SDWA § 1457 Chemicals— 

Initial Response Form for Consortium’’ 

(EPA Form No. 6300–06–C). March 27, 

2013. Available in Attachment D(4) to 

the ICR in Docket ID Number EPA–HQ– 

OPPT–2013–0275. 

22. EPA. Central Data Exchange Web site at 

http://www.epa.gov/cdx. 

23. EPA. Claims of Confidentiality of Certain 

Chemical Identities Submitted under 

Section 8(e) of the Toxic Substances 

Control Act; Notice. Federal Register (75 

FR 3462, January 21, 2010) (FRL–8807– 

9). 

List of Subjects 

Environmental protection, Chemicals, 

Endocrine disruptors, Pesticides and 

pests, Safe drinking water, Reporting 

and recordkeeping. 

Dated: May 29, 2013. 

James Jones, 

Acting Assistant Administrator, Office of 

Chemical Safety and Pollution Prevention. 

[FR Doc. 2013–14228 Filed 6–13–13; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–OPPT–2009–0477; FRL–9375–8] 

Endocrine Disruptor Screening 

Program; Final Second List of 

Chemicals and Substances for Tier 1 

Screening 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: This document announces the 

final second list of 109 chemicals 

identified for Tier 1 screening under the 

Endocrine Disruptor Screening Program 

(EDSP). The EDSP is established under 

section 408(p) of the Federal Food, 

Drug, and Cosmetic Act (FFDCA), which 

requires EPA to develop a chemical 

screening program using appropriate 

validated test systems and other 

scientifically relevant information to 

determine whether certain substances 

may have hormonal effects. 

FOR FURTHER INFORMATION CONTACT: For 

technical information contact: Hannah 

Holsinger, Office of Water, 1200 

Pennsylvania Ave. NW., Washington, 

DC 20460–0001 (MC–4607M); telephone 

number: (202) 564–0403, email address: 

holsinger.hannah@epa.gov, or Pat West, 

Office of Science Coordination and 

Policy, Environmental Protection 

Agency, 1200 Pennsylvania Ave. NW., 

Washington, DC 20460–0001 (MC– 

7201M); telephone number: (202) 564– 

1656, email address: west.pat@epa.gov. 

For general information contact: The 

TSCA-Hotline, ABVI-Goodwill, 422 

South Clinton Ave., Rochester, NY 

14620; telephone number: (202) 554– 

1404; email address: TSCAHotline@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. General Information 

A. Does this action apply to me? 

You may be potentially affected by 

this action if you produce, manufacture, 

use, or import chemicals (including 

pesticide chemicals) that may be found 

in sources of drinking water; if you 

manufacture or import chemicals that 

degrade to chemicals found in sources 

of drinking water; or if you are, or may 

otherwise be, involved in the testing of 

chemicals for potential endocrine 

effects. The following list of North 

American Industrial Classification 

System (NAICS) codes is not intended 

to be exhaustive, but rather provides a 

guide to help readers determine whether 

this document applies to them. 

Potentially affected entities may 

include: 

• Chemical manufacturers, importers 

and processors (NAICS code 325), e.g., 

persons who manufacture, import or 

process chemical substances. 

• Pesticide, fertilizer, and other 

agricultural chemical manufacturers 

(NAICS code 3253), e.g., persons who 

manufacture, import or process 

pesticide, fertilizer and agricultural 

chemicals. 

• Scientific research and 

development services (NAICS code 

5417), e.g., persons who conduct testing 

of chemical substances for endocrine 

effects. 

B. How can I get copies of this document 

and other related information? 

The docket for this action, identified 

by docket identification (ID) number 

EPA–HQ–OPPT–2009–0477, is available 

at http://www.regulations.gov or at the 

Office of Pollution Prevention and 

Toxics Docket (OPPT Docket), 

Environmental Protection Agency 

Docket Center (EPA/DC), EPA West 

Bldg., Rm. 3334, 1301 Constitution Ave. 

NW., Washington, DC. The Public 

Reading Room is open from 8:30 a.m. to 

4:30 p.m., Monday through Friday, 

excluding legal holidays. The telephone 

number for the Public Reading Room is 

(202) 566–1744, and the telephone 

number for the OPPT Docket is (202) 

566–0280. Please review the visitor 

instructions and additional information 

about the docket available at http:// 

www.epa.gov/dockets. 

II. Background 

A. What action is the agency taking? 

This document announces the final 

second list of 109 chemicals identified 

for Tier 1 screening under the Endocrine 

Disruptor Screening Program (EDSP). 

The EDSP is established under section 

408(p) of the Federal Food, Drug, and 

Cosmetic Act (FFDCA), which requires 

EPA to develop a chemical screening 

program using appropriate validated test 

systems and other scientifically relevant 

information to determine whether 

certain substances may have hormonal 

effects. After considering comments 

received on the draft second list of 

chemicals and substances published in 

the Federal Register notice of November 

17, 2010 (75 FR 70248) (FRL–8848–7) 

(Ref. 1), EPA is announcing the final list 

of the second group of chemicals that 

will be subject to screening based on the 

approach described in the notice— 

‘‘Endocrine Disruptor Screening 

Program; Final Policies and Procedures 

for Screening Safe Drinking Water Act 

(SDWA) Chemicals,’’ published 

elsewhere in today’s Federal Register. 

The EDSP consists of a two-tiered 

approach to screen and test chemicals 

for potential endocrine disrupting 

effects. The purpose of Tier 1 screening 

is to identify substances that have the 

potential to interact with the endocrine 

system (specifically the estrogen, 

androgen, or thyroid hormone systems) 

using a battery of assays. Substances 

that have the potential to interact with 

estrogen, androgen or thyroid systems 

may proceed to Tier 2, which is 

designed to identify any adverse 

endocrine-related effects caused by the 

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Federal Register / Vol. 78, No. 115 / Friday, June 14, 2013 / Notices 35923 

substance, and establish a quantitative 

relationship between the dose and that 

endocrine effect. This second list should 

not be construed as a list of known or 

likely endocrine disruptors. Nothing in 

the approach for generating the second 

list provides a basis to infer that by 

simply being on this list these chemicals 

are suspected to interfere with the 

endocrine systems of humans or other 

species, and it would be inappropriate 

to do so. In a separate notice published 

elsewhere in today’s Federal Register, 

EPA describes other aspects of EDSP 

such as the administrative procedures 

that EPA will use to require testing. 

The second group of chemicals to be 

tested consists of chemicals that section 

408(p) of the FFDCA (Ref. 2) requires be 

screened, i.e., pesticide active 

ingredients and chemicals used as 

pesticide inert ingredients (also known 

as other ingredients) and section 1457 of 

the 1996 amendment to the SDWA (Ref. 

3). EPA developed this final list using 

the approach outlined in the Federal 

Register notice announcing the draft 

second list of chemicals and substances 

(Ref. 1). More information on EPA’s 

priority setting approach is available at 

http://www.epa.gov/scipoly/oscpendo/ 

pubs/prioritysetting. 

This document does not describe 

other aspects of EDSP such as the 

administrative procedures EPA 

generally intends to use to require 

testing, the validated tests and battery 

that will be included in EDSP, or the 

timeframe for requiring the testing or 

receiving the data. The administrative 

procedures that EPA generally intends 

to use are described in a separate notice 

published elsewhere in today’s Federal 

Register. The remaining topics will be 

addressed in separate notices that will 

be subsequently published in the 

Federal Register. 

B. What is the agency’s authority for 

taking this action? 

FFDCA section 408(p) requires EPA to 

‘‘develop a screening program, using 

appropriate validated test systems and 

other scientifically relevant information, 

to determine whether certain substances 

may have an effect in humans that is 

similar to an effect produced by a 

naturally occurring estrogen, or such 

other endocrine effect as [EPA] may 

designate’’ (21 U.S.C. 346a(p)). Section 

408(p)(3) generally requires EPA to 

‘‘provide for the testing of all pesticide 

chemicals’’ and gives EPA discretionary 

authority to ‘‘provide for the testing of 

any other substance that may have an 

effect that is cumulative to an effect of 

a pesticide chemical if the 

Administrator determines that a 

substantial population may be exposed 

to such a substance’’ (21 U.S.C. 

346a(p)(3)). The statute also authorizes 

EPA to exempt a chemical upon a 

determination that ‘‘the substance is 

anticipated not to produce any effect in 

humans similar to an effect produced by 

a naturally occurring estrogen.’’ (21 

U.S.C. 346a(p)(4)). 

Section 1457 of SDWA states that ‘‘in 

addition to the substances’’ referred to 

in FFDCA section 408(p)(3)(B), ‘‘the 

Administrator may provide for testing 

under the screening program authorized 

by section 408(p) of such Act, in 

accordance with the provisions of 

section 408(p) of such Act, of any other 

substance that may be found in sources 

of drinking water if the Administrator 

determines that a substantial population 

may be exposed to such substance’’ (42 

U.S.C. 300j–17). EPA used its authority 

under SDWA to identify a portion of the 

chemicals on the second EDSP list. 

III. History 

EPA developed EDSP in response to 

a Congressional mandate in FFDCA ‘‘to 

determine whether certain substances 

may have an effect in humans that is 

similar to an effect produced by a 

naturally occurring estrogen, or such 

other endocrine effect as [EPA] may 

designate’’ (21 U.S.C. 346a(p)). Unit II.B. 

describes the authority for listing a 

chemical. As part of EDSP, EPA issues 

orders to collect certain test data on 

selected chemical substances. In 

general, EPA intends to use the data 

collected under EDSP, along with other 

information, to determine if a pesticide 

chemical or other substances may pose 

a risk to human health or the 

environment due to disruption of the 

endocrine system. The determination 

that a chemical does or is not likely to 

have the potential to interact with the 

endocrine system will be made on a 

weight-of-evidence basis taking into 

account data from the Tier 1 assays and/ 

or other scientifically relevant 

information. Chemicals that go through 

Tier 1 screening and are found to have 

the potential to interact with the 

estrogen, androgen, or thyroid hormone 

systems will proceed to the next state of 

EDSP where EPA will determine which, 

if any, of the Tier 2 tests are necessary 

based on available data. Tier 2 testing is 

designed to identify any adverse 

endocrine-related effects caused by the 

substance, and establish a quantitative 

relationship between the dose and that 

endocrine effect. Further information 

regarding EDSP and requirements for 

Tier 1 and Tier 2 testing can be found 

on the Agency’s EDSP Web site, at 

http://www.epa.gov/endo/. 

IV. Development of the Second EDSP 

List 

The House Appropriations Committee 

report for EPA’s FY 2010 appropriations 

(H.R. 2996, H. Rept. 111–180) (Ref. 4), 

directed EPA to publish within 1 year 

of enactment a second list of no less 

than 100 chemicals for screening that 

includes drinking water contaminants, 

such as halogenated organic chemicals, 

dioxins, flame retardants 

polybrominated diphenyl ethers, 

polychlorinated biphenyls, 

perfluorocarbons (PFCs), plastics, 

bisphenol A, pharmaceuticals and 

personal care products, and issue 25 

orders per year for the testing of these 

chemicals. This process also should 

allow for public input. In response, EPA 

published a draft second list of 

chemicals for Tier 1 screening on 

November 17, 2010 and solicited public 

comments on the list of chemicals. The 

development of the draft second list is 

described at length in that Federal 

Register notice (Ref. 1). 

EPA received comment letters from 

approximately 60 organizations or 

individuals on the November 17, 2010 

draft second EDSP list. These 

organizations/individuals included a 

water-related association, 

environmental advocacy groups, 

chemical industry, consumer and pet 

advocacy groups, and consultants 

writing on behalf of the industry. This 

notice summarizes major comments 

EPA received, along with the Agency’s 

response. A complete listing of public 

comments and EPA’s responses related 

to the draft second list of chemicals for 

Tier 1 screening are included in the 

document entitled ‘‘Final Comment 

Response Document for the Second 

Endocrine Disruptor Screening Program 

List (Categorized Public Comments).’’ 

The document is available in the docket 

for this action under docket ID number 

EPA–HQ–OPPT–2009–0477. 

A. SDWA 1457 

Some commenters stated that EPA 

had not met the requirements of SDWA 

1457 when listing the draft second 

EDSP list. They stated that a chemical’s 

inclusion on the third Contaminant 

Candidate List (CCL3) does not mean 

that the chemical meets SDWA 1457 

requirements. SDWA 1457 states that 

‘‘the Administrator may provide for 

testing under the screening program 

authorized by section 408(p) of such 

Act, . . . of any other substance that 

may be found in sources of drinking 

water if the Administrator determines 

that a substantial population may be 

exposed to such substance.’’ SDWA 

section 1457 sets forth the criteria for 

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the selection of substances for EDSP. 

Section 1457 does not require the 

Agency to promulgate regulations 

further defining these criteria. 

For the EDSP, EPA selected 

contaminants from the CCL3, for which 

EPA had evaluated the nature of the 

occurrence and prevalence information 

(Ref. 5), and selected contaminants from 

National Primary Drinking Water 

Regulations (NPDWRs), which were 

designated by Congress for regulation 

due to concerns about occurrence in 

drinking water and adverse impacts on 

human health. The scientific basis for 

EPA’s selection of contaminants on the 

CCL3 also provides the basis for EPA’s 

determination that a chemical may be 

found in sources of drinking water to 

which a substantial population may be 

exposed for the purposes of SDWA 

section 1457. 

B. Support for Contaminants Listed in 

the Draft Second List 

The Agency received comments 

supporting the contaminants included 

on the draft second EDSP list. One 

commenter stated that the draft second 

EDSP list was an appropriate starting 

point since it was developed from 

existing NPDWRs and the CCL3. 

Another commenter acknowledged that 

many of the chemicals included on the 

draft second EDSP list have already 

undergone a rigorous review within the 

Agency for exposure potential in 

vulnerable populations and noted there 

is incomplete toxicity data for the 

general population. The commenter 

stated that EDSP will contribute 

important information about endocrine 

disrupting potential of chemicals which 

have never been tested for sensitive 

endpoints in estrogen, androgen, and 

thyroid hormone disruption. 

C. Exclusion or Inclusion of 

Contaminants 

EPA received comments concerning 

contaminants that are no longer 

manufactured or that have been 

cancelled (banned), indicating these 

should be removed from the list. EPA 

also received comments related to 

chemicals with physiochemical 

properties that would likely result in 

test assay incompatibility issues. EPA 

agrees that contaminants derived from 

chemicals that have been banned or are 

no longer manufactured should be 

removed from the list. EPA has 

generally determined that it would be 

reasonable to prioritize testing for those 

compounds which a manufacturer, 

importer, or registrant is clearly 

identifiable and the Agency could order 

these entities to conduct the testing. 

Chemicals that have been banned or are 

no longer manufactured (or imported) 

do not fit within this category. EPA also 

agrees that it would be reasonable to 

exclude chemicals from the second list 

based on the highly reactive 

physiochemical properties of the 

chemicals and test assay incompatibility 

issues. The exclusion rationales for 

streamlining the second EDSP list are 

discussed in the Federal Register notice 

for the draft second list (Ref. 1). 

Table 1 of this notice contains a list 

of chemicals that EPA believes should 

be removed from the final second list 

because they are no longer 

manufactured, are banned chemicals, or 

the chemicals have physiological 

properties that make them highly 

reactive and incompatible with the 

testing assays. Other chemicals remain 

on the list as they are still in use and 

may be found in sources of drinking 

water (see Unit IV.A. of this notice). 

Other comments EPA received stated 

those chemicals with a maximum 

contaminant level goal of zero should be 

removed. EPA recognizes that it may not 

be possible to set more stringent levels 

for some of these chemicals at this time. 

However, it is important to note that 

most of the chemicals with maximum 

contaminant level goals of zero are 

based on chronic health endpoints and 

compounds with endocrine disrupting 

effects that can be subchronic. Also, it 

would be important to understand 

whether a chemical might be an 

endocrine disruptor with subchronic 

impacts since this may inform the 

Agency’s risk assessment and how best 

to address this contaminant from a 

regulatory standpoint. In addition, if 

endocrine effects occur at a level lower 

than the current maximum contaminant 

level, the Agency might consider 

whether improvements in analytical 

feasibility, which would allow 

measurements at the level of endocrine 

effects, have been developed since the 

promulgation of the existing MCLs. 

EPA also received comments stating 

that the Agency should have included 

some chemicals (e.g., triclosan, 

alkylphenols and alkylphenol 

polyethoxylates, bisphenol A, musk 

fragrances, and pharmaceutical 

estrogens) with known or suspected 

endocrine disrupting effects on the 

second list. When compiling the second 

EDSP list, EPA focused on priority 

drinking water contaminants and 

pesticides previously identified by EPA. 

These priority chemicals included the 

CCL3 chemicals, chemicals with 

NPDWRs, and registration review 

pesticides. The basis for chemical 

selection is described in the Federal 

Register notice for the draft second list 

(Ref. 1). While the chemicals mentioned 

in the comments were not included on 

the current EDSP list, they may be 

included on future EDSP lists. Several 

of the chemicals suggested by 

commenters were evaluated as part of 

the CCL3 process but did not make the 

final CCL3 for reasons that are outlined 

in EPA supporting documents ‘‘Final 

Contaminant Candidate List 3 

Chemicals: Identifying the Universe, 

Final Contaminant Candidate List 3 

Chemicals: Screening to a PCCL,’’ and 

‘‘Final Contaminant Candidate List 3 

Chemicals: PCCL to CCL’’ (Refs. 6, 7, 

and 8). 

As for the current approach for 

selecting chemicals for the second EDSP 

list, EPA excluded chemicals that are 

hormones with confirmed effects as 

stated in the Federal Register notice for 

the draft second list (Ref. 1). EPA did 

not give weight to information on the 

potential for a chemical to cause 

endocrine effects as criteria for listing as 

the purpose of the second EDSP list is 

to identify substances that have the 

potential to interact with the endocrine 

system using appropriate validated test 

systems and other scientifically relevant 

information. The final second EDSP list 

should neither be construed as a list of 

known or likely endocrine disruptors 

nor characterized as such. 

Some commenters also stated that 

naturally occurring contaminants 

should be excluded from the draft 

second EDSP list. EPA sought and used 

the best available information regarding 

all substances on the draft second EDSP 

list, including those that have the 

potential to naturally occur. Although 

EPA acknowledges that some substances 

on the list (e.g., acetaldehyde, 

acrylamide, methanol, and perchlorate) 

can occur naturally in the environment, 

this is not the only known pathway of 

occurrence for these chemicals to enter 

into the environment. A basis for 

chemical selection includes selecting 

substances that are known or 

anticipated to occur in public drinking 

water. Anthropogenic pathways for 

these chemicals to enter the 

environment are shown through data 

from the Toxic Release Inventory (TRI), 

Chemical Update System/Inventory 

Update Rule (CUS/IUR), and chemical 

manufacturing information. 

Consequently, EPA does not believe that 

the fact that these chemicals can occur 

naturally is sufficient reason to exclude 

the manufacturers and importers of 

these chemicals from conducting the 

necessary testing. 

D. Pesticide Registration Review Issues 

EPA received comments stating that 

pesticide active ingredients should not 

be included on EDSP list and suggesting 

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Federal Register / Vol. 78, No. 115 / Friday, June 14, 2013 / Notices 35925 

that issuance of test orders should align 

with pesticide registration review 

schedules. 

The Agency is working toward 

integrating EDSP and the Registration 

Review Program, such that the data 

gathering may be completed in a 

coordinated manner under these two 

programs to permit a timely registration 

review decision inclusive of EDSP and 

not rely on the fixed chemical list 

approach for active ingredients. 

Ultimately, EPA intends that chemicals 

scheduled for registration review may 

receive EDSP test orders and the data 

submitted in response to those orders 

are coordinated with the submission of 

data required under registration review. 

The Agency may then review and 

evaluate the data submitted for both 

programs in the same time frame, 

complete the risk assessment with EDSP 

outcomes as appropriate, and likely 

conclude registration review for a given 

chemical within the schedule, 

enhancing efficiency. Currently, 

however, EPA does not have an 

information collection request (ICR) 

clearance to issue orders to require 

EDSP testing generally for registration 

review chemicals. While the ICR 

clearance process continues, EPA 

continues to rely on the chemical list 

approach for the fiscal year 2007/2008 

registration review chemicals in an 

attempt to begin to address EDSP testing 

for the early registration review 

chemicals. 

V. The Final Second List of Chemicals 

and Substances for Tier 1 Screening 

A. Chemicals and Substances Removed 

From the Draft Second List for Tier 1 

Screening 

EPA removed 25 chemicals and 

substances from the draft second list 

based on two of the criteria published 

in the November 17, 2010 issue of the 

Federal Register, (Ref. 1): 

1. Chemicals for which the 

manufacturer, importer or registrant 

cannot be clearly identified (criterion 

two). 

2. Chemicals not likely to be 

biologically active or which are 

incompatible with testing assays for 

various reasons due to one or more of 

their physiochemical properties 

(criterion five). 

EPA reevaluated the draft second list of 

chemicals and substances based on 

public comments and determined that 

sufficient data exist to remove a total of 

25 additional contaminants based on 

criterion two (n=21) and criterion five 

(n=4). Table 1 presents an alphabetized 

list of 25 chemicals and substances EPA 

removed from the original list of 134 

proposed for Tier 1 screening and 

provides the rationale for removal. 

Although these chemicals have been 

removed from the second group of 

chemicals and substances that EPA will 

screen, it is important to note that the 

removal of these chemicals and 

substances does not imply that the 

Agency has no interest in the potential 

for endocrine disruption activity for 

these contaminants. At this time the 

Agency realizes that there is some 

difficulty with collecting the 

information about endocrine effects 

through EDSP because of the Agency’s 

inability to identify a manufacturer, 

importer, or registrant or because the 

contaminant is incompatible with the 

testing assays. 

TABLE 1—CHEMICALS REMOVED FROM DRAFT SECOND EDSP LIST

Chemical name CAS Reg No. SDWA PAI Rationale 

1. 1, 2-Dibormo-3-chlorproprane (DBCP) .... 96–12–8 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

2. 2, 4, 5–TP (Silvex) ................................... 93–72–1 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

3. Benzyl chloride ........................................ 100–44–7 X ........................ Physiochemical properties—highly reactive; 

incompatible with the testing assays. 

4. Chlordane ................................................ 57–74–9 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

5. Cumene hydroperoxide ........................... 80–15–9 X ........................ Physiochemical properties—highly reactive; 

incompatible with the testing assays. 

6. Dalapon ................................................... 75–99–0 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

7. Dimethipin ................................................ 55290–64–7 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

8. Dinoseb .................................................... 88–85–7 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

9. Endrin ...................................................... 72–20–8 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

10. Ethylene dibromide (EDB) ..................... 106–93–4 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

11. Fenamiphos ........................................... 22224–92–6 X X Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

12. Fenarimol ............................................... 60168–88–9 ........................ X Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

13. Fenoxycarb ............................................ 72490–01–8 ........................ X Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

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35926 Federal Register / Vol. 78, No. 115 / Friday, June 14, 2013 / Notices 

TABLE 1—CHEMICALS REMOVED FROM DRAFT SECOND EDSP LIST—Continued 

Chemical name CAS Reg No. SDWA PAI Rationale 

14. Heptachlor ............................................. 76–44–8 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

15. Heptachlor epoxide ................................ 1024–57–3 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

16. Methoxychlor ......................................... 72–43–5 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

17. Molinate ................................................. 2212–67–1 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

18. Oxirane, methyl- .................................... 75–56–9 X ........................ Physiochemical properties—highly reactive; 

incompatible with the testing assays. 

19. Propetamphos ....................................... 31218–83–4 ........................ X Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

20. Pyridate .................................................. 55512–33–9 ........................ X Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

21. Sodium tetrathiocarbonate .................... 7345–69–9 ........................ X Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

22. Sulfosate ................................................ 81591–81–3 ........................ X Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

23. Temephos .............................................. 3383–96–8 ........................ X Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

24. Toxaphene ............................................. 8001–35–2 X ........................ Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely. 

25. Triethylamine ......................................... 121–44–8 X ........................ Physiochemical properties—highly reactive; 

incompatible with the testing assays. 

Endnotes—Table 1: 

• TRI contains information on toxic chemical releases from facilities that meet reporting criteria (for most chemicals the thresholds are 25,000 

pounds for manufacturing and processing and 10,000 pounds for use). 

• IUR contains site and manufacturing information for chemicals manufactured (including imported) in amounts of 25,000 pounds or greater at 

a single site. 

B. The Final Second List of Chemical 

and Substances for EDSP Tier 1 

Screening 

Table 2 presents an alphabetized list 

of the 109 chemicals and substances 

included in the final second EDSP list 

of chemicals for Tier 1 screening. As in 

the draft second list, the final list 

includes pesticides, two PFCs, and three 

pharmaceuticals (erythromycin, 

nitroglycerin, and quinoline). The list 

also consists of an array of other 

chemicals ranging from those used for 

industrial manufacturing processes, as 

plasticizers, or in the production of 

pharmaceutical, personal care products, 

and toxic substances. Because this list of 

chemicals was selected on the basis of 

exposure potential only, it should 

neither be construed as a list of known 

or likely endocrine disruptors nor 

characterized as such. 

TABLE 2—FINAL SECOND EDSP LIST OF CHEMICALS FOR TIER 1 SCREENING

Chemical name CAS Reg No. SDWA PAI 

1. 1,1,1,2-Tetrachloroethane ................................................................................................. 630–20–6 X ........................

2. 1,1,1-Trichloroethane ......................................................................................................... 71–55–6 X ........................

3. 1,1,2-Trichloroethane ......................................................................................................... 79–00–5 X ........................

4. 1,1-Dichloroethane ............................................................................................................ 75–34–3 X ........................

5. 1,1-Dichloroethylene .......................................................................................................... 75–35–4 X ........................

6. 1,2,3-Trichloropropane ...................................................................................................... 96–18–4 X ........................

7. 1,2,4-Trichlorobenzene ...................................................................................................... 120–82–1 X ........................

8. 1,2-Dichloroethane ............................................................................................................ 107–06–2 X ........................

9. 1,2-Dichloropropane .......................................................................................................... 78–87–5 X ........................

10. 1,3-Dinitrobenzene .......................................................................................................... 99–65–0 X ........................

11. 1,4-Dioxane ..................................................................................................................... 123–91–1 X ........................

12. 1-Butanol ......................................................................................................................... 71–36–3 X ........................

13. 2-Methoxyethanol ............................................................................................................ 109–86–4 X ........................

14. 2-Propen-1-ol ................................................................................................................... 107–18–6 X ........................

15. 4,4’-Methylenedianiline .................................................................................................... 101–77–9 X ........................

16. Acetaldehyde ................................................................................................................... 75–07–0 X ........................

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TABLE 2—FINAL SECOND EDSP LIST OF CHEMICALS FOR TIER 1 SCREENING—Continued 

Chemical name CAS Reg No. SDWA PAI 

17. Acetamide ........................................................................................................................ 60–35–5 X ........................

18. Acetochlor ........................................................................................................................ 34256–82–1 X X 

19. Acetochlor ethanesulfonic acid (ESA) ............................................................................. 187022–11–3 X ........................

20. Acetochlor oxanilic acid (OA) .......................................................................................... 194992–44–4 X ........................

21. Acrolein ............................................................................................................................ 107–02–8 X X 

22. Acrylamide ....................................................................................................................... 79–06–1 X ........................

23. Alachlor ............................................................................................................................ 15972–60–8 X X 

24. Alachlor ethanesulfonic acid (ESA) ................................................................................. 142363–53–9 X ........................

25. Alachlor oxanilic acid (OA) .............................................................................................. 171262–17–2 X ........................

26. alpha-Hexachlorocyclohexane ......................................................................................... 319–84–6 X ........................

27. Aniline .............................................................................................................................. 62–53–3 X ........................

28. Bensulide ......................................................................................................................... 741–58–2 X X 

29. Benzene ........................................................................................................................... 71–43–2 X ........................

30. Benzo(a)pyrene (PAHs) .................................................................................................. 50–32–8 X ........................

31. Butylated hydroxyanisole ................................................................................................. 25013–16–5 X ........................

32. Carbon tetrachloride ........................................................................................................ 56–23–5 X ........................

33. Chlorobenzene ................................................................................................................ 108–90–7 X ........................

34. cis-1,2-Dichloroethylene .................................................................................................. 156–59–2 X ........................

35. Clethodim ......................................................................................................................... 99129–21–2 X X 

36. Clofentezine ..................................................................................................................... 74115–24–5 ........................ X 

37. Clomazone ....................................................................................................................... 81777–89–1 ........................ X 

38. Coumaphos ..................................................................................................................... 56–72–4 ........................ X 

39. Cyanamide ....................................................................................................................... 420–04–2 ........................ X 

40. Cyromazine ...................................................................................................................... 66215–27–8 ........................ X 

41. Denatonium saccharide ................................................................................................... 90823–38–4 ........................ X 

42. Di(2-ethylhexyl) adipate ................................................................................................... 103–23–1 X ........................

43. Dichloromethane .............................................................................................................. 75–09–2 X ........................

44. Dicrotophos ...................................................................................................................... 141–66–2 X X 

45. Diuron .............................................................................................................................. 330–54–1 X X 

46. Endothall .......................................................................................................................... 145–73–3 X X 

47. Epichlorohydrin ................................................................................................................ 106–89–8 X ........................

48. Erythromycin .................................................................................................................... 114–07–8 X ........................

49. Ethylbenzene ................................................................................................................... 100–41–4 X ........................

50. Ethylene glycol ................................................................................................................ 107–21–1 X ........................

51. Ethylene thiourea ............................................................................................................. 96–45–7 X ........................

52. Ethylurethane ................................................................................................................... 51–79–6 X ........................

53. Etofenprox ....................................................................................................................... 80844–07–1 ........................ X 

54. Fenoxaprop-P-ethyl ......................................................................................................... 71283–80–2 ........................ X 

55. Flumetsulam .................................................................................................................... 98967–40–9 ........................ X 

56. Fomesafen sodium .......................................................................................................... 108731–70–0 ........................ X 

57. Fosetyl-Al (Aliette) ........................................................................................................... 39148–24–8 ........................ X 

58. Glufosinate ammonium .................................................................................................... 77182–82–2 ........................ X 

59. HCFC–22 ......................................................................................................................... 75–45–6 X ........................

60. Hexachlorobenzene ......................................................................................................... 118–74–1 X ........................

61. Hexachlorocyclopentadiene ............................................................................................. 77–47–4 X ........................

62. Hexane ............................................................................................................................ 110–54–3 X ........................

63. Hexythiazox ..................................................................................................................... 78587–05–0 ........................ X 

64. Hydrazine ......................................................................................................................... 302–01–2 X ........................

65. Isoxaben .......................................................................................................................... 82558–50–7 ........................ X 

66. Lactofen ........................................................................................................................... 77501–63–4 ........................ X 

67. Lindane ............................................................................................................................ 58–89–9 X ........................

68. Methanol .......................................................................................................................... 67–56–1 X ........................

69. Methyl tert-butyl ether ...................................................................................................... 1634–04–4 X ........................

70. Metolachlor ethanesulfonic acid (ESA) ........................................................................... 171118–09–5 X ........................

71. Metolachlor oxanilic acid (OA) ........................................................................................ 152019–73–3 X ........................

72. Nitrobenzene ................................................................................................................... 98–95–3 X ........................

73. Nitroglycerin ..................................................................................................................... 55–63–0 X ........................

74. N-Methyl-2-pyrrolidone .................................................................................................... 872–50–4 X ........................

75. N-Nitrosodimethylamine (NDMA) .................................................................................... 62–75–9 X ........................

76. n-Propylbenzene .............................................................................................................. 103–65–1 X ........................

77. o-Dichlorobenzene ........................................................................................................... 95–50–1 X ........................

78. o-Toluidine ....................................................................................................................... 95–53–4 X ........................

79. Oxydemeton-methyl ......................................................................................................... 301–12–2 X X 

80. Oxyfluorfen ...................................................................................................................... 42874–03–3 X X 

81. Paclobutrazol ................................................................................................................... 76738–62–0 ........................ X 

82. p-Dichlorobenzene ........................................................................................................... 106–46–7 X X 

83. Pentachlorophenol ........................................................................................................... 87–86–5 X X 

84. Perchlorate ...................................................................................................................... 14797–73–0 X ........................

85. Perfluorooctane sulfonic acid (PFOS) ............................................................................. 1763–23–1 X ........................

86. Perfluorooctanoic acid (PFOA) ........................................................................................ 335–67–1 X ........................

87. Picloram ........................................................................................................................... 1918–02–1 X X 

88. Polychlorinated biphenyls ................................................................................................ 1336–36–3 X ........................

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TABLE 2—FINAL SECOND EDSP LIST OF CHEMICALS FOR TIER 1 SCREENING—Continued 

Chemical name CAS Reg No. SDWA PAI 

89. Profenofos ....................................................................................................................... 41198–08–7 X X 

90. Propionic acid .................................................................................................................. 79–09–4 ........................ X 

91. Quinclorac ........................................................................................................................ 84087–01–4 ........................ X 

92. Quinoline .......................................................................................................................... 91–22–5 X ........................

93. Quizalofop-P-ethyl ........................................................................................................... 100646–51–3 ........................ X 

94. RDX ................................................................................................................................. 121–82–4 X ........................

95. sec-Butylbenzene ............................................................................................................ 135–98–8 X ........................

96. Styrene ............................................................................................................................ 100–42–5 X ........................

97. Terbufos ........................................................................................................................... 13071–79–9 X X 

98. Terbufos sulfone .............................................................................................................. 56070–16–7 X ........................

99. Tetrachloroethylene ......................................................................................................... 127–18–4 X ........................

100. Thiophanate-methyl ....................................................................................................... 23564–05–8 X X 

101. Toluene diisocyanate ..................................................................................................... 26471–62–5 X ........................

102. trans-1,2-Dichloroethylene ............................................................................................. 156–60–5 X ........................

103. Trichloroethylene ........................................................................................................... 79–01–6 X ........................

104. Triflumizole .................................................................................................................... 68694–11–1 ........................ X 

105. Trinexapac-ethyl ............................................................................................................ 95266–40–3 ........................ X 

106. Triphenyltin hydroxide (TPTH) ...................................................................................... 76–87–9 X X 

107. Vinclozolin ...................................................................................................................... 50471–44–8 X X 

108. Xylenes (total) ................................................................................................................ 1330–20–7 X X 

109. Ziram .............................................................................................................................. 137–30–4 X X 

Total .................................................................................................................................................................. 88 41 

VI. References 

The following is a list of the 

documents that are specifically 

referenced in this document. These 

references are available at http:// 

www.regulations.gov. 

1. USEPA. 2010. Endocrine Disruptor 

Screening Program; Second List of 

Chemicals for Tier 1 Screening; Notice. 

Federal Register, 75 FR 70248, 

November 17, 2010. 

2. USEPA. 1996. FFDCA section 408(p). 

Available on-line at http:// 

epw.senate.gov/FDA_001.pdf. 

3. USEPA. 1996. Amendments to the Safe 

Drinking Water Act. Available on-line at: 

http://water.epa.gov/lawsregs/guidance/ 

sdwa/text.cfm. 

4. U.S. Congress. House Report 111–180. 

Available at: http://www.gpo.gov/fdsys/ 

pkg/CRPT-111hrpt180/pdf/CRPT111hrpt180.pdf. 

5. USEPA. 2009. Drinking Water 

Contaminant Candidate List 3—Final; 

Notice. Federal Register. Vol. 74. No 

194. p. 51850. October 8, 2009. 

6. USEPA. 2009. Final Contaminant 

Candidate List 3 Chemicals: Identifying 

the Universe, EPA 815–R–09–006. 

August 2009. 

7. USEPA. 2009. Final Contaminant 

Candidate List 3 Chemicals: Screening to 

a PCCL, EPA 815–R–05–007. August, 

2009. 

8. USEPA. 2009. Final Contaminant 

Candidate List 3 Chemicals: 

Classification of the PCCL to the CCL, 

EPA 815–R–09–008. August, 2009. 

List of Subjects 

Environmental protection, Chemicals, 

Drinking water, Endocrine disruptors, 

Pesticides. 

Dated: May 29, 2013. 

James Jones, 

Acting Assistant Administrator, Office of 

Chemical Safety and Pollution Prevention. 

[FR Doc. 2013–14232 Filed 6–13–13; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[ER–FRL–9009–6] 

Environmental Impacts Statements; 

Notice of Availability 

Responsible Agency: Office of Federal 

Activities, General Information (202) 

564–7146 or http://www.epa.gov/ 

compliance/nepa/. 

Weekly receipt of Environmental Impact 

Statements 

Filed 06/03/2013 through 06/07/2013. 

Pursuant to 40 CFR 1506.9. 

Notice 

Section 309(a) of the Clean Air Act 

requires that EPA make public its 

comments on EISs issued by other 

Federal agencies. EPA’s comment letters 

on EISs are available at: http:// 

www.epa.gov/compliance/nepa/ 

eisdata.html. 

EIS No. 20130160, Final EIS, USFS, OR, 

McKay Fuels and Vegetation 

Management Project, Review Period 

Ends: 07/15/2013, Contact: Marcy 

Anderson 541–416–6463. 

EIS No. 20130161, Draft EIS, USFS, MT, 

East Reservoir Project, Comment 

Period Ends: 07/29/2013, Contact: 

Denise Beck 406–293–7773, ext. 7504. 

EIS No. 20130162, Final EIS, BLM, NM, 

SunZia Southwest Transmission 

Project, Proposed Resource 

Management Plan Amendments, 

Review Period Ends: 07/15/2013, 

Contact: Adrian Garcia 505–954– 

2199. 

EIS No. 20130163, Draft EIS, FERC, AL, 

Martin Dam Hydroelectric Project, 

Relicensing, Comment Period Ends: 

08/13/2013, Contact: Stephen Bowler 

202–502–6861. 

EIS No. 20130164, Revised Draft EIS, 

USAF, FL, F–35 Beddown at Eglin Air 

Force Base, Comment Period Ends: 

07/29/2013, Contact: Mike Spaits 

850–882–2836. 

EIS No. 20130165, Draft EIS, BLM, SD, 

South Dakota Resource Management 

Plan, Comment Period Ends: 09/11/ 

2013, Contact: Mitch Iverson 605– 

892–7008. 

EIS No. 20130166, Final EIS, USFWS, 

NiSource Multi-Species Habitat 

Conservation Plan, Review Period 

Ends: 07/15/2013, Contact: Thomas J. 

Magnuson 612–713–5467. 

EIS No. 20130167, Draft EIS, NOAA, MI, 

Thunder Bay National Marine 

Sanctuary, Boundary Expansion, 

Comment Period Ends: 08/14/2013, 

Contact: Jeff Gray 989–356–8805. 

EIS No. 20130168, Final EIS, USACE, 

CA, Feather River West Levee Project 

Final 408 Permission, Review Period 

Ends: 07/15/2013, Contact: Jeffery 

Koschak 916–557–6994. 

EIS No. 20130169, Final Supplement, 

NRC, TN, Operation of Watts Bar 

Nuclear Plant, Unit 2 NUREG–0498, 

Supplement 2, Review Period Ends: 

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