UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460



### MEMORANDUM

Date: April 8, 2013 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION



### SUBJECT: Fluopicolide Chronic Aggregate Dietary ( Food and Drinking Water) Exposure and Risk Assessment for the Section 3 Tolerances on Rotational Corn.



### PC Code: 02741 2 

### Decision No.: 471299 

### Petition No.: 2F8099 

### Risk Assessment Type: Dietary TXR 

### No.: N/A MRID 

### No.: 48809201,48842201 

### DP Barcode: D407936 

### Registration No.: 59639-140 

### Regulatory Action: Section 3 Registration 

### Case No.: N/A 

### CAS No.: 239110-15-7 40 

### CFR: §180.627



### FROM: AlaaKamel,Ph.D.,Chemist 

### 0\**~** Risk Assessment Branch V 

### Nil Health Effects Division (7509 P )



### THROUGH: Michael S. Metzger, Chief

# ' (} /) /) 

# M ____-- Risk Assessment Branch V / VII

## ~..JJt 

# X**~** Health Effects Division (7509 and Douglas A. Dotson, Ph.D., Chemist 

## f),**/)~** Nancy Dodd

, Chemist**-J~.-** 

### .. _ 

### '"'::Z .AL..r**~/** Dietary Exposure Science Advi s ory Council (DESAC)



### TO: Tony Kish!Dominic Schuler, RM #22 Fungicide Branch Registration Division (7505P)



### Executive Summary

A chronic aggregate dietary (food and drinking water) exposure 

### and risk assessment was conducted for fluopicolide using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food

Page 1 of 11Fluopicolide Dietary Exposure and Ri sk Assessment DP Number: 0407936

consumption data from t he U.S. Departm ent of Agricu lture 's (USDA 's ) National Health and Nutrition Examination Survey, What We Eat in America, (NHANES / WWEIA). The analysis

was conducted t o s upport a Section 3 request for fluopicolide toler ances on rotational field corn. This memorandum was reviewed by two pe er reviewers of the DESAC

, per DESAC SOP 20 12 .1.

Chronic Dietary (Food and Drinking Wate r ) Exposure Results and Characterization Chronic dietary risks for the U.S Popula tion and all population subgroups are not of concern. The established and ne w ly proposed uses of fluopicolide re su lt in an estimated exposure to the U.S. Population equivalent to 7.6% ofthe chronic population adjusted dose ( cPAD). The highest exposed subgroup is chil dr en 1

- 2 years of age with an estimated exposure equivalent to 12% of the cPAD. This assessment i s considered highly conservat ive as tolerance -l evel residues for rotati on al field corn were added to the previous assessment conduct e d in 20 10 (D38 10 50, D. Davis

, 8/19 / 201 0). The assessment also assumes 100% crop treated and uses em pirical or default processing factors.

Acute dietary exposure and cancer risk assessments were not conducted because an en dp oint attributable to a s ingle do se has not been identified for fluopicolide and H E D has classi fied it as

" not likely to be carcinogenic to humans. "



### I. Introduction

Dietary risk assessment incorporates both exposure and tox icity of a given pesticide. For acute and chronic asses s ment s, the risk is expressed as a percentage of a maximum acceptable dose (i.e.

, the dose that HED has concluded will result in no umeasonable adverse health effects). This dose is referred to as the population-adju ste d dose (PAD). Th e PAD i s equiva lent to the point of departure (POD

, N OAEL

, LOAEL

, e.g.) di v ided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments 

### in

more detail are available on the EPA/pesticides web site : " Available Information on Assessing Ex posure from Pe st icides

, A User's Guide ," 21-JUN-2000, web linlc http: // www

. epa.gov / fedrgstr/EPA

- PEST / 2000 / July/Day

- 12 / 606l.pdf or see SOP 99.6 (20-AUG1999)

.

T h e most recen t dietary risk assessmen t for fluopicolide was conducted in 2 010 by the Health Effects Division (D381050, D. Davis

, 8 / 19 /2 010).

Residues of 2,6-dichlorobenzamide (BAM), the main metabolite of fluopico li de

, are considered to be of regulatory concern; h o wever, sepa rate toxicit y data and endpoints for risk assessment have been

se l ected and

, thus, a se parate risk assessment i s required for BAM. However

, s ince the new tolerances do not add significant l y to the BAM dietary ex p osure , th e co n clusions from the most

recen tly conducted BAM dietary risk as s e ss men t remain unchanged

, and a revised BAM ri sk
assessment is not r eq uired to suppo rt the se new uses. Thi s assessment addresses risks from the parent compound and it s regulated metabolites

, ot h er than BAM.

Pa ge 2 of 11Fluopicolide Dietary Exposure and Risk A ssessment DP Number: D407936

Page 3 of 11 

### The Agency previously reviewed petitions 5F7016, 7E7172, 9F7617 for uses on B rassica leafy greens subgroup 5B, potatoes, sugar beets, carrots and tolerances on rotational wheat. The assessment concluded that the c hronic dietary (food and drinking water) estimated risks were below HED’s level of concern for the U.S. population and all population subgroups. Data deficiencies, however, remained outstanding pending the fulfillment of the 40 CFR § 158 requirement of conducting an immunotoxicity study. Recently, Valent submitted an 

### immunotoxicity study (MRID 48809201) along with the current petition to fulfill these requirements

. 

### This assessment includes the newly proposed tolerances on rotational field corn and the updated toxicological endpoints after submission of the new data.

II. Residue Information

Tolerances are established under 40 CFR § 

### 180.627 (d) for indirect or inadvertent residues of fluopicolide, 2,6

- dichloro

- N

- [[3

- chloro

- 5

- (trifl uoromethyl)

- 2

- pyridinyl]methyl] benzamide, including its metabolite s and degradates. Compliance with the t olerance levels is to be determined by measuring only fluopicolide in or on the commodity. No livestock tolerances have been est ablished for fluopicolide.

The fluopicolide residues of concern for rotational corn are shown in Table 1

.

Table 1. Summary of Fluopicolide Residues of Concern

.

Matrix Residues included in Risk Assessment Residues included in Tolerance Expression

Cereal grains

- grain for human food F luopicolide (parent)
, PCA, P1 x and BAM Fluopicolide

Cereal grains

- forage/hay/straw and grain for livestock feed Fluopicolide (parent) and BAM Fluopicolide

In the most recent dietary exposure and risk assessment (D381050, D. Davis 2010)

, tolerance

level residues for the proposed and established uses were included in the assessment

, with the exception of tuberous and corm vegetables (subgroup 1C), tomato fractions, and rotational wheat commodities, where the maximum residues from the field trial data and empirical processing factors were used. Maximum metabolite residues were converted to parent equivalents and added to the maximum fluopicolide residue value observed in the field tr ia l data to obtain a t otal residue value. As indicated, the fluopicolide metabolite BAM will not be included in this assessment. A separate risk assessment for BAM, however

, is not necessary and will not be conducted. For the purpose of this risk assessment, tolerance

- level r esidues for the proposed and established residues for the parent fluopicolide in/on corn grain were included

. Empirical processing factors were incorporated, except for corn syrup where the default processing factor was included. Since m etabolite residues of PAC and P1 x were not detected (below the limit of detection, LOD) in grain or processed fractions at the 1x and 2x application rates , half the LOD (0.005 ppm) of each metabolite was added to the residues of the parent fluopicolide for this
assessment

. As a result, a value of 0.02 ppm was used for corn commodities. There are noFluopicolide Dietary Exposure and Risk A ssessment DP Number: D407936

Page 4 of 11 

### livestock tolerances required for the established and newly proposed uses. Where available, empirical data were used to determine appropriate values for processed commodities ; otherwise, DEEM

– FCID 3.16 default concentration factors were applied to the raw agricultural commodity residue level. The assessment assumed 100% crop treated. A summary of the newly proposed tol erances is shown in Table 2 . Processing factors used ar e shown in Table 3

.

Table 2. New Use Tolerance Summary for Fluopicolide

. Commodity Proposed Tolerance (ppm) Recommended

Tolerance (ppm) Comments; Correct

Commodity Definition

Tolerances to be established under (d ) Indirect or inadvertent residues Corn, field, grain 0.01 0.01



### Table 3. Summary of Processing Factors for Fluopicolide

Matrix Max Reported Residues (ppm) Conversion

Factors 2

Grain < 0.010

-- Flour < 0.010 NC
Grits < 0.010 NC
Meal < 0.010 NC
Starch < 0.010 NC Refined oil, dry milled 0.017 >1.7x Refined oil, wet milled 0.021 >2.1x



### III . Drinking Water Data

The drinking water residues were used in the latest dietary risk assessment conducted in 2010 (D381050, D. Davis, 2010), which were provided by the Environmental Fate and Effects Division (EFED) in the memorandum: “Tier II Drinking Water Exposure Assessmen t for Fluopicolide and its Major Degradate, 2,6

- Dichlorbenzamide (BAM) for Use on Potatoes, Carrots, Sugar Beets and Brassica (Cole) Leafy Vegetables ” (R. Miller, D370764, 6/20/10) and incorporated directly into the dietary assessment. Water residues of 0 .02414 ppm were incorporated in the DEEM

- FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.”

For the new use of fluopicolide on rotational corn, EFED has indicated that a new drinking water assessment (DWA) wa s not needed ( Email communication with Michael Lowit , EFED 3/19/2013 ).

I V. DEEM

- FCID Program and Consumption Information

A f luopicolide chronic dietary exposure assessment w as conducted using the DEEM

- FCID, Version 3.16 , which incorporates 2003

- 2008 co nsumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) areFluopicolide Dietary Exposure and Risk A ssessment DP Number: D407936

Page 5 of 11 

### linked to EPA

- defined food commodities (e.g.

, apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entir e U.S. population and within population subgroups . However , for acute exposure assessment , consumption data are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estim ate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

V

. Toxicological Information

The i mmunotoxicity study submitted did not impact the endpo ints selected for fluopicolide. The immunotoxic ity NOAEL was 130 mg/kg /day based on decreased total spleen activity observed at 1015 mg/kg/day. The toxicological doses and endpoints selected are the same as the endpoints used in the last assessment and are summarized in Table 4

.

Table 4 . Summary of Toxicological Doses and Endpoints for Fluopicolide for Use in Dietary Exposure Risk Assessments

Exposure/ Scenario Point of

Departure Uncertainty/

FQPA Safety Factors RfD, PAD, Level of

Concern Study and Toxicological Effects Acute Dietary (All Populations) An endpoint attributable to a single dose was not identified from the available data.

Chronic Dietary (All Populations) Maternal

NOAEL=20 mg/kg/day

NOAEL =31.5 mg/kg/day (co

- critical study) UF A =10x

UF H =10x FQPA SF = 1X Chronic RfD =

cRfD = 0.2 mg/kg/day

cPAD = 0.2 mg/kg/day Developmental Toxicity Study in

Rabbits LOAEL (maternal) = 60 mg/kg/day based on death, abortions/pre mature deliveries, decreased food consumption and body weight gain.

Chronic Oncogenicity Study in Rats (co

- critical study) LOAEL = 109.4 mg/kg/day based on decreased body weight gain and increased thyroid weight and increased incidence of thyroid lesions.Fluopicolide Dietary Exposure and Risk A ssessment DP Number: D407936

Page 6 of 11 Table 4 . Summary of Toxicological Doses and Endpoints for Fluopicolide for Use in Dietary Exposure Risk Assessments

Exposure/ Scenario Point of

Departure Uncertainty/

FQPA Safety Factors RfD, PAD, Level of

Concern Study and Toxicological Effects Cancer (oral, dermal, inhalation) Classification: “ Not Likely to be Carcinogenic to Humans ”

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no ob served adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (c = chronic). RfD = reference dose.



### VII. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM

- FCID analyses estimate the dietary exposure and risk of the U.S. population and various population subgroups. The results reported in Table 5 are for the general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 1 9, females 13

- 49, adults 20

- 49, and adults 50

- 99 years.

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The established and newly proposed uses of fluopicolide result ed in an estimated exposure to the U.S. Population which is equ ivalent to 7. 6 % of the cPAD. The high est exposed subgroup is children 1

– 2 years of age with an estimated exposure equivalent to 1 2 % of the cPAD. Results for all subpopulations are shown in the table below.

Table 5 . Summary of Dietary (Food and Drinking Water) Exposure and Risk for Fluopicolide.

Population Subgroup Acute Dietary Chronic Dietary Cancer
Dietary Exposure (mg/kg/day) % aPAD* Dietary Exposure (mg/kg/day) % cPAD* Dietary Exposure (mg/kg/day) Risk

General U.S. Population



### N/A N/A 0.015176 7.6



### N/A N/A All Infants (<1 year old) 0.010336 5.2
Children 1

- 2 years old 0.024340 12
Children 3

- 5 years old 0.022836 11
Children 6

- 12 years old 0.014425 7.2
Youth 13

- 19 years old 0.011252 5.6
Adults 20

- 49 years old 0.014965 7.5
Adults 50

- 99 years old 0.015368 7.7
Females 13

- 49 years old 0.015252 7.6



### *The subpopulation with the highest risk estimate is bolded.Fluopicolide Dietary Exposure and Risk A ssessment DP Number: D407936

Page 7 of 11 

### VII. Characterization of Inputs/Outputs

The chronic dietary exposure and risk analyses are based on tolerance

- level residues, 100% crop treated assumptions, and default processing factors. Various refinements could be made to the
assessments . H owever, as there are no risk estimates of concern, no refinements were incorporated.

VI II

. Conclusions

The chronic dietary risk from the established and newly proposed uses of fluopicolide is not of concern for the U.S. population or any population subgroup. This assessment is not likely to underestimate risk.

X. List of Attachments

Attachment 1. Chronic Dietary Input File Attachment 2. Chronic Dietary Results FileFluopicolide Dietary Exposure and Risk A ssessment DP Number: D407936

Page 8 of 11 

### Attachment 1. Fluopicolide Chronic Dietary Input File
US EPA Ver. 3.16, 03

- 08

- d
DEEM

- FCID Chronic analysis for FLUOPICOLIDE Residue file: C: \ DEEM \ CalendexWWEIAFCID \ FLUOPIC corn inadv CHRONIC F_W.R08 Adjust. #2 used Analysis Date 04

- 08

- 2013 Residue file dated: 04

- 08

- 2013/09:06:03 Referen ce dose (RfD) = 0.2 mg/kg bw/day Comment:Addition of CG1, CG5B and rotational wheat uses to labels.

---------------------------------------------------------------------------------- Food Crop Residue Adj.Facto rs EPA Code Grp Food Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ 0401005000 4A Amaranth, leafy 25.000000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.090000 1.000 1.000 0103015001 1CD Arrowroot, flour

- babyfood 0.090000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.090000 1.000 1.000 0401018000 4A Arugula 25.000000 1.000 1.000 0902021000 9B Balsam pear 0.500000 1.000 1.000 0101050000 1AB Beet, garden, roots 0.150000 1.000 1.000 0101050001 1AB Beet, garden, root s
- babyfood 0.150000 1.000 1.000 0200051000 2 Beet, garden, tops 15.000000 1.000 1.000 0101052000 1A Beet, sugar 0.150000 1.000 1.000 0101052001 1A Beet, sugar

- babyfood 0.150000 1.000 1.000 0101053000 1A Beet, sugar, molasses 0.150000 1.000 1.000 0101053001 1A Beet, sugar, molasses

- babyfood 0.150000 1.000 1.000 0501061000 5A Broccoli 5.000000 1.000 1.000 0501061001 5A Broccoli

- babyfood 5.000000 1.000 1.000 0501062000 5A Broccoli, Chinese 5.000000 1.000 1.000 0502063000 5B Broccoli raab 18.000000 1.000 1.000 0501064000 5A Brussels sprouts 5.000000 1.000 1.000 0101067000 1AB Burdock 0.150000 1.000 1.000 0501069000 5A Cabb age 5.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 18.000000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 5.000000 1.000 1.000 0501072000 5A Cabbage, Chine se, mustard 5.000000 1.000 1.000 0901075000 9A Cantaloupe 0.500000 1.000 1.000 0402076000 4B Cardoon 25.000000 1.000 1.000 0101078000 1AB Carrot 0.150000 1.000 1.000 0101078001 1AB Carrot

- babyfood 0.150000 1.000 1.000 0101079000 1AB Carrot, juice 0.150000 1.000 1.000 0103082000 1CD Cassava 0.090000 1.000 1.000 0103082001 1CD Cassava

- babyfood 0.090000 1.000 1.000 0501083000 5A Cauliflower 5.000000 1.000 1.000 0101084000 1AB Celeriac 0.150000 1.000 1.000 0402085000 4B Celery 25.000000 1.000 1.000 0402085001 4B Celery

- babyfood 25.000000 1.000 1.000 0402086000 4B Celery, juice 25.000000 1.000 1.000 0402087000 4B Celtuce 25.000000 1.000 1.000 0902088000 9B Chayote, fruit 0.500000 1.000 1.000 0101100000 1AB Chicory, roots 0.150000 1.000 1.000 0200101000 2 Chicory, tops 15.000000 1.000 1.000 0902102000 9B Chinese waxgourd 0.500000 1.000 1.000 0302103000 3B Chive, fresh leaves 7.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 25.000000 1.000 1.000 0502117000 5B Collards 18.000000 1.000 1.000 1500120000 15 Corn, field, flour 0.020000 1.000 1.000 1500120001 15 Corn, field, flour

- babyfood 0.020000 1.000 1.000 1500121000 15 Corn, field, meal 0.020000 1.000 1.000 1500121001 15 Corn, field, meal

- babyfood 0.020000 1.000 1.000 1500122000 15 Corn , field, bran 0.020000 1.000 1.000 1500123000 15 Corn, field, starch 0.020000 1.000 1.000 1500123001 15 Corn, field, starch

- babyfood 0.020000 1.000 1.000 1500124000 15 Corn, field, s yrup 0.020000 1.500 1.000 1500124001 15 Corn, field, syrup

- babyfood 0.020000 1.500 1.000 1500125000 15 Corn, field, oil 0.020000 2.100 1.000 1500125001 15 Corn, field, oil

- babyfoo d 0.020000 2.100 1.000Fluopicolide Dietary Exposure and Risk A ssessment DP Number: D407936

Page 9 of 11 1500126000 15 Corn, pop 0.020000 1.000 1.000 0401133000 4A Cress, garden 25.000000 1.000 1.000 0401134000 4A Cress, upland 25.000000 1.000 1.000 0902135000 9B Cucumber 0.500000 1.000 1.000 0401138000 4A Dandelion, leaves 25.000000 1.000 1.000 0103139000 1CD Dasheen, corm 0.090000 1.000 1.000 0200140000 2 Dasheen, leaves 15.000000 1.000 1.000 0802148000 8BC Eggplant 1.600000 1.000 1.000 0401150000 4A Endive 25.000000 1.000 1.000 0402152000 4B Fennel, Florence 25.000000 1.000 1.000 0301165000 3A Garlic, bulb 7.000000 1.000 1.000 0301165001 3A Garlic, bulb

- babyfood 7.000000 1.000 1.000 0103166000 1CD Ginger 0.090000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.090000 1.000 1.000 0103167000 1CD Ginger, dried 0.090000 1.000 1.000 0101168000 1AB Ginseng, dried 0.150000 1.000 1.000 1304175000 13D Grape 2.000000 1.000 1.000 1304176000 13D Grape, juice 2.000000 1.000 1.000 1304176001 13D Grape, juice

- babyfood 2.000000 1.000 1.000 9500177000 O Grape, leaves 2.000000 1.000 1.000 9500178000 O Grape, raisin 6.000000 1.000 1.000 1304179000 13D Grap e, wine and sherry 2.000000 1.000 1.000 0901187000 9A Honeydew melon 0.500000 1.000 1.000 0101190000 1AB Horseradish 0.150000 1.000 1.000 0502194000 5B Kale 18.000000 1.000 1.000 0501196000 5A Kohlrabi 5.000000 1.000 1.000 0302198000 3B Leek 7.000000 1.000 1.000 0401204000 4A Lettuce, head 25.000000 1.000 1.000 0401205000 4A Lettuce, leaf 25.000000 1.000 1.000 0502229000 5B Mustard greens 18.000000 1.000 1.000 0802234000 8BC Okra 1.600000 1.000 1.000 0301237000 3A Onion, bulb 7.000000 1.000 1.000 0301237001 3A Onion, bulb

- babyfood 7.000000 1.000 1.000 0301238000 3A Onion, bulb, dried 7.000000 9.000 1.000 0301238001 3A Onion, bulb, dried

- babyfood 7.000000 9.000 1.000 0302239000 3B Onion, green 7.000000 1.000 1.000 0401248000 4A Parsley, leaves 25.000000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.150000 1.000 1.000 0101251000 1AB Parsnip 0.150000 1.000 1.000 0101251001 1AB Parsnip

- babyfood 0.150000 1.000 1.000 0802270000 8B Pepper, bell 1.600000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 1.600000 1.000 1.000 0802271000 8B Pepper, bell, dried 1.600000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 1.600000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.600000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 1.600000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.600000 1.000 1.000 0103296000 1C Potato, chips 0.090000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.090000 1.000 1.000 0103297001 1C Pota to, dry (granules/ flakes)

- b 0.090000 1.000 1.000 0103298000 1C Potato, flour 0.090000 1.000 1.000 0103298001 1C Potato, flour

- babyfood 0.090000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.090000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.090000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.090000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.090000 1.000 1.000 0902308000 9B Pumpkin 0.500000 1.000 1.000 0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 0401313000 4A Radicchio 25.000000 1.000 1.000 0101314000 1AB Radish, roots 0.150000 1.000 1.000 0200315000 2 Radish, tops 15.000000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 0.150000 1.000 1.000 0200317000 2 Radish, Oriental, tops 15.000000 1.000 1.000 0502318000 5B Rape greens 18.000000 1.000 1.000 0402322000 4B Rhubarb 25.000000 1.000 1.000 0101327000 1AB Rutabaga 0.150000 1.000 1.000 0101331000 1AB Salsify, roots 0.150000 1.000 1.000Fluopicolide Dietary Exposure and Risk A ssessment DP Number: D407936

Page 10 of 11 0200332000 2 Salsify, tops 15.000000 1.000 1.000 0302338500 3B Shallot, fresh leaves 7.000000 1.000 1.000 0401355000 4A Spinach 25.000000 1.000 1.000 0401355001 4A Spinach

- babyfood 25.000000 1.000 1.000 0902356000 9B Squash, summer 0.500000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.500000 1.000 1.000 0902357000 9B Squash, winter 0.500000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.500000 1.000 1.000 0103366000 1CD Sweet potato 0.090000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 0.090000 1.000 1.000 0402367000 4B Swis s chard 25.000000 1.000 1.000 0103371000 1CD Tanier, corm 0.090000 1.000 1.000 0801374000 8A Tomatillo 1.600000 1.000 1.000 0801375000 8A Tomato 1.600000 1.000 1.000 0801375001 8A Tomato

- babyfood 1.600000 1.000 1.000 0801376000 8A Tomato, paste 1.600000 1.000 1.000 0801376001 8A Tomato, paste

- babyfood 1.600000 1.000 1.000 0801377000 8A Tomato, puree 1.600000 1.000 1.000 0801377001 8A Tomato, puree

- babyfood 1.600000 1.000 1.000 0801378000 8A Tomato, dried 1.600000 14.300 1.000 0801378001 8A Tomato, dried

- babyfood 1.600000 14.300 1.000 0801379000 8A Tomato, juice 1.600000 1.000 1.000 0103387000 1CD Turmeric 0.090000 1.000 1.000 0101388000 1AB Turnip, roots 0.150000 1.000 1.000 0502389000 5B Turnip, greens 15.000000 1.000 1.000 8601000000 86A Water, direct, all sources 0.024140 1.000 1.000 8602000000 86B Water, indirect, all sources 0.024140 1.000 1.000 0901399000 9A Watermelon 0.500000 1.000 1.000 0901400000 9A Watermelon, juice 0.500000 1.000 1.000 1500401000 15 Wheat, grain 0.230000 1.000 1.000 1500401001 15 Wheat, grain

- babyfood 0.230000 1.000 1.000 1500402000 15 Wheat, flour 0.230000 1.000 1.000 1500402001 15 Wheat, flour

- babyfood 0.230000 1.000 1.000 1500403000 15 Wheat, germ 0.240000 1.000 1.000 1500404000 15 Wheat, bran 0.490000 1.000 1.000 0103406000 1CD Yam, true 0.090000 1.000 1.000 0103407000 1CD Yam bean 0.090000 1.000 1.000Fluopicolide Dietary Exposure and Risk A ssessment DP Number: D407936

Page 11 of 11 

### Attachment 2. Fluopicolide Chronic Dietary Assessment Results

US EPA Ver. 3.16, 03

- 08

- d
DEEM

- FCID Chronic analysis for FLUOPICOLIDE NHANES 2003

- 2008 2

- day Residue file name: C: \ DEEM \ CalendexWWEIAFCID \ FLUOPIC corn inadv CHRONIC F_W.R08 Adjustment factor #2 used. Analysis Date 04

- 08

- 2013/09:06:45 Residue file dated: 04

- 08

- 2013/09:06:03 Reference dose (RfD, Chronic) = .2 mg/kg bw/day COMMENT 1: Addition of CG1, CG5B and rotational wheat uses to labels.

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.015176 7.6% Hispanic 0.014200 7.1%
Non

- Hisp

- White 0.015641 7.8%
Non

- Hisp

- Black 0.012625 6.3%
Non

- Hisp

- Other 0.017581 8.8% Nursing Infants 0.006320 3.2%
Non

- Nursing Infants 0.012130 6.1% Female 13+ PREG 0.013881 6.9% Children 1

- 6 0.022827 11.4% Children 7

- 12 0.013536 6.8% Male 13

- 19 0.010670 5.3% Female 13

- 19/NP 0.011837 5.9% Male 20+ 0.013907 7.0% Female 20+/NP 0.016293 8.1% Seniors 55+ 0.015247 7.6% All Infants 0.010336 5.2% Female 13

- 50 0.015235 7.6% Children 1

- 2 0.024340 12.2% Children 3

- 5 0.022836 11.4% Children 6

- 12 0.0 14425 7.2% Youth 13

- 19 0.011252 5.6% Adults 20

- 49 0.014965 7.5% Adults 50

- 99 0.015368 7.7% Female 13

- 49 0.015252 7.6%

-------------------------------------------------------------------------------