Federal Register / Vol. 76, No. 4 / Thursday, January 6, 2011 / Notices 787 

has determined that domestically 

manufactured goods are not currently 

available. The information provided is 

sufficient to meet the following criteria 

listed under Section 1605(b) of the 

ARRA and in the April 28, 2009 

Memorandum: Iron, steel, and the 

manufactured goods are not produced in 

the United States in sufficient and 

reasonably available quantities and of a 

satisfactory quality. Therefore, EPA has 

determined that a nationwide 

categorical waiver for this product is 

appropriate. 

This waiver expires one year from the 

day it takes effect. Furthermore, EPA 

reserves the right to withdraw or amend 

this nationwide waiver based on new 

developments or changes in the 

domestic manufacturing capacity for 

these items. 

Authority: Pub. L. 111–5, section 1605. 

Dated: December 29, 2010. 

Michael H. Shapiro, 

Acting Assistant Administrator for Water. 

[FR Doc. 2011–19 Filed 1–5–11; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–ORD–2009–0605; FRL–9248–4] 

Notice of Availability of the 

Recommended Toxicity Equivalence 

Factors (TEFs) for Human Health Risk 

Assessments of 2,3,7,8– 

Tetrachlorodibenzo-p-dioxin and 

Dioxin-Like Compounds 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice of document availability. 

SUMMARY: The U.S. Environmental 

Protection Agency (EPA) is announcing 

the availability of the final 

‘‘Recommended Toxicity Equivalence 

Factors (TEFs) for Human Health Risk 

Assessments of 2,3,7,8– 

Tetrachlorodibenzo-p-dioxin and 

Dioxin-Like Compounds’’ (EPA/100/R– 

10/005). The purpose of this document 

is to assist EPA scientists in using the 

toxicity equivalence methodology to 

assess health risks from dioxins and 

dioxin-like compounds, as well as 

inform EPA decision makers, other 

agencies, and the public about this 

methodology. This guidance document 

summarizes the toxicity equivalence 

methodology, provides background 

information and assumptions on how 

the methodology has evolved, and 

recommends an approach for health risk 

assessors to use to apply the 

methodology. EPA’s Risk Assessment 

Forum (RAF) oversaw the development 

of this document. Input was obtained 

from scientists throughout the Agency, 

from interested members of the public, 

and from external experts from a range 

of scientific disciplines via a contractorled peer review. 

ADDRESSES: The final document is 

available electronically through the EPA 

Office of the Science Advisor’s Web site 

at: http://www.epa.gov/osa/raf/ 

hhtefguidance/. A limited number of 

paper copies will be available from 

EPA’s National Service Center for 

Environmental Publications (NSCEP), 

P.O. Box 42419, Cincinnati, OH 45242; 

telephone number: 1–800–490–9198 or 

513–489–8190; facsimile number: 301– 

604–3408; e-mail: NSCEP@bpslmit.com. Please provide your name, 

mailing address, and title of the 

requested publication. 

FOR FURTHER INFORMATION CONTACT: Julie 

Fitzpatrick, Risk Assessment Forum 

Staff, Mail Code 8105R, Environmental 

Protection Agency, 1200 Pennsylvania 

Avenue, NW., Washington, DC 20460; 

telephone number: (202) 564–4212; 

facsimile number: (202) 564–2070; email: fitzpatrick.julie@epa.gov. 

SUPPLEMENTARY INFORMATION: Dioxin 

and dioxin-like compounds (DLCs), 

including polychlorinated dibenzodioxins (PCDDs), polychlorinated 

dibenzofurans (PCDFs), and 

polychlorinated biphenyls (PCBs), are 

structurally and toxicologically related 

halogenated dicyclic aromatic 

hydrocarbons. Dioxins and DLCs are 

released into the environment from 

several industrial sources, including 

chemical manufacturing, combustion, 

and metal processing. There is global 

contamination of air, soil and water 

with trace levels of these compounds. 

Typically, dioxins and DLCs occur in 

the environment as chemical mixtures. 

Dioxins and DLCs do not readily 

degrade; therefore, levels persist in the 

environment, build up in the food 

chain, and accumulate in the tissues of 

animals. Human exposures to these 

compounds occur primarily through 

eating contaminated foods. The health 

effects from exposures to dioxins and 

DLCs have been documented 

extensively in toxicological and 

epidemiological studies. 

Risk assessments have relied on the 

dioxin toxicity equivalence factors 

(TEFs) approach. Various stakeholders, 

inside and outside the Agency, have 

called for a more comprehensive 

characterization of risks. Therefore, 

EPA’s RAF identified a need to examine 

the current recommended approach for 

application of the toxicity equivalence 

methodology in human health risk 

assessments. An RAF Technical Panel 

developed the draft guidance document, 

‘‘Recommended Toxicity Equivalence 

Factors (TEFs) for Human Health Risk 

Assessments of 2,3,7,8– 

Tetrachlorodibenzo-p-dioxin and 

Dioxin-Like Compounds,’’ to assist EPA 

scientists in using this methodology to 

assess health risks from dioxins and 

dioxin-like compounds, and inform EPA 

decision makers, other agencies, and the 

public about this methodology. 

An external expert peer review was 

conducted by both letter and an open, 

public teleconference in October 2009. 

The peer review panel was provided 

with the public comments received in 

the official public docket for this 

activity under docket ID number EPA– 

HQ–ORD–2009–0605. The peer review 

panel also had the opportunity to hear 

public comments provided during the 

peer review teleconference. In preparing 

the final document, EPA considered the 

public comments submitted to EPA’s 

docket during the public comment 

period and during the public 

teleconference, and the 

recommendations from the external peer 

reviewers provided in the peer review 

report and during the public 

teleconference. 

EPA is currently addressing several 

issues related to dioxins and dioxin-like 

chemicals in the environment. More 

information on these activities is located 

at: http://www.epa.gov/dioxin/ 

scienceplan/. 

Dated: December 22, 2010. 

Paul T. Anastas, 

EPA Science Advisor. 

[FR Doc. 2011–20 Filed 1–5–11; 8:45 am] 

BILLING CODE 6560–50–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Centers for Disease Control and 

Prevention 

Advisory Committee on Breast Cancer 

in Young Women (ACBCYW) 

In accordance with section 10(a)(2) of 

the Federal Advisory Committee Act 

(Pub. L. 92–463), the Centers for Disease 

Control and Prevention (CDC), 

announces the following meeting of the 

aforementioned committee: 

Times and Dates 

9 a.m.–5 p.m., January 31, 2011. 

8 a.m.–3 p.m., February 1, 2011. 

Place: Emory Conference Center Hotel 

and Emory Inn, 1615 Clifton Road, NE., 

Atlanta, Georgia 30329. 

Status: Open to the public, limited 

only by the space available. 


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