UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MEMORANDUM 

Date: April 8, 2013 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

SUBJECT: Fluopicolide Chronic Aggregate Dietary (Food and Drinking Water) Exposure 

and Risk Assessment for the Section 3 Tolerances on Rotational Corn. 

PC Code: 02741 2 

Decision No.: 471299 

Petition No.: 2F8099 

Risk Assessment Type: Dietary 

TXR No.: N/A 

MRID No.: 48809201,48842201 

DP Barcode: D407936 

Registration No.: 59639-140 

Regulatory Action: Section 3 Registration 

Case No.: N/A 

CAS No.: 239110-15-7 

40 CFR: §180.627 

FROM: 

Risk 

Health 

AlaaKamel,Ph.D.,Chemist 

Assessment 

Effects Division 

Branch 

(7509

V Nil 

P) 

0\ ~ 

THROUGH: Michael S. Metzger, Chief ' (} /) /) M ____--

Risk Assessment Branch V /VII ~..JJt X ~ Health Effects Division (7509 

and 

Douglas A. Dotson, Ph.D., Chemist f), /)~ 

Nancy Dodd, Chemist -J~.- .. _ '"'::Z .AL..r ~/ 

Dietary Exposure Science Advisory Council (DESAC) 

TO: Tony Kish!Dominic Schuler, RM #22 

Fungicide Branch 

Registration Division (7505P) 

Executive Summary 

A chronic aggregate dietary (food and drinking water) exposure and risk assessment was 

conducted for fluopicolide using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food 

Page 1 of 11 
Fluopicolide Dietary Exposure and Risk Assessment DP Number: 0407936 

consumption data from the U.S. Department of Agriculture's (USDA's) National Health and 

Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). The analysis 

was conducted to support a Section 3 request for fluopicolide tolerances on rotational field corn. 

This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 

2012.1. 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization 

Chronic dietary risks for the U.S Population and all population subgroups are not of concern. 

The established and newly proposed uses of fluopicolide result in an estimated exposure to the 

U.S. Population equivalent to 7.6% ofthe chronic population adjusted dose (cPAD). The highest 

exposed subgroup is children 1 - 2 years of age with an estimated exposure equivalent to 12% of 

the cPAD. This assessment is considered highly conservative as tolerance-level residues for 

rotational field corn were added to the previous assessment conducted in 2010 (D381050, D. 

Davis, 8/19/201 0). The assessment also assumes 100% crop treated and uses empirical or 

default processing factors. 

Acute dietary exposure and cancer risk assessments were not conducted because an endpoint 

attributable to a single dose has not been identified for fluopicolide and HED has classified it as 

"not likely to be carcinogenic to humans." 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no umeasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: "Available Information on Assessing 

Exposure from Pesticides, A User's Guide," 21-JUN-2000, web linlc 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/606l.pdf or see SOP 99.6 (20-AUG1999). 

The most recent dietary risk assessment for fluopicolide was conducted in 2010 by the Health 

Effects Division (D381050, D. Davis, 8/19/2010). 

Residues of 2,6-dichlorobenzamide (BAM), the main metabolite of fluopicolide, are considered to be 

of regulatory concern; however, separate toxicity data and endpoints for risk assessment have been 

selected and, thus, a separate risk assessment is required for BAM. However, since the new 

tolerances do not add significantly to the BAM dietary exposure, the conclusions from the most 

recently conducted BAM dietary risk assessment remain unchanged, and a revised BAM risk 

assessment is not required to support these new uses. This assessment addresses risks from the 

parent compound and its regulated metabolites, other than BAM. 

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Fluopicolide Dietary Exposure and Risk Assessment DP Number: D407936

Page 3 of 11

The Agency previously reviewed petitions 5F7016, 7E7172, 9F7617 for uses on Brassica leafy 

greens subgroup 5B, potatoes, sugar beets, carrots and tolerances on rotational wheat. The 

assessment concluded that the chronic dietary (food and drinking water) estimated risks were below 

HED’s level of concern for the U.S. population and all population subgroups. Data deficiencies, 

however, remained outstanding pending the fulfillment of the 40 CFR §158 requirement of 

conducting an immunotoxicity study. Recently, Valent submitted an immunotoxicity study (MRID 

48809201) along with the current petition to fulfill these requirements. This assessment includes 

the newly proposed tolerances on rotational field corn and the updated toxicological endpoints 

after submission of the new data.

II. Residue Information

Tolerances are established under 40 CFR §180.627(d) for indirect or inadvertent residues of 

fluopicolide, 2,6-dichloro-N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]benzamide, 

including its metabolites and degradates. Compliance with the tolerance levels is to be 

determined by measuring only fluopicolide in or on the commodity. No livestock tolerances 

have been established for fluopicolide. 

The fluopicolide residues of concern for rotational corn are shown in Table 1.

Table 1. Summary of Fluopicolide Residues of Concern.

Matrix Residues included in 

Risk Assessment

Residues included 

in Tolerance 

Expression

Cereal grains - grain for human food Fluopicolide (parent), 

PCA, P1x and BAM Fluopicolide

Cereal grains - forage/hay/straw and 

grain for livestock feed

Fluopicolide (parent) 

and BAM Fluopicolide

In the most recent dietary exposure and risk assessment (D381050, D. Davis 2010), tolerancelevel residues for the proposed and established uses were included in the assessment, with the 

exception of tuberous and corm vegetables (subgroup 1C), tomato fractions, and rotational wheat

commodities, where the maximum residues from the field trial data and empirical processing 

factors were used. Maximum metabolite residues were converted to parent equivalents and 

added to the maximum fluopicolide residue value observed in the field trial data to obtain a total 

residue value. As indicated, the fluopicolide metabolite BAM will not be included in this 

assessment. A separate risk assessment for BAM, however, is not necessary and will not be 

conducted. For the purpose of this risk assessment, tolerance-level residues for the proposed and 

established residues for the parent fluopicolide in/on corn grain were included. Empirical 

processing factors were incorporated, except for corn syrup where the default processing factor 

was included. Since metabolite residues of PAC and P1x were not detected (below the limit of 

detection, LOD) in grain or processed fractions at the 1x and 2x application rates, half the LOD 

(0.005 ppm) of each metabolite was added to the residues of the parent fluopicolide for this 

assessment. As a result, a value of 0.02 ppm was used for corn commodities. There are no 
Fluopicolide Dietary Exposure and Risk Assessment DP Number: D407936

Page 4 of 11

livestock tolerances required for the established and newly proposed uses. Where available, 

empirical data were used to determine appropriate values for processed commodities; otherwise, 

DEEM –FCID 3.16 default concentration factors were applied to the raw agricultural commodity 

residue level. The assessment assumed 100% crop treated. A summary of the newly proposed 

tolerances is shown in Table 2. Processing factors used are shown in Table 3.

Table 2. New Use Tolerance Summary for Fluopicolide.

Commodity Proposed 

Tolerance 

(ppm)

Recommended 

Tolerance 

(ppm)

Comments; Correct 

Commodity Definition

Tolerances to be established under (d) Indirect or inadvertent residues

Corn, field, grain 0.01 0.01

Table 3. Summary of Processing Factors for Fluopicolide

Matrix

Max Reported 

Residues (ppm)

Conversion 

Factors2

Grain <0.010 --

Flour <0.010 NC

Grits <0.010 NC

Meal <0.010 NC

Starch <0.010 NC

Refined oil, dry milled 0.017 >1.7x

Refined oil, wet milled 0.021 >2.1x

III. Drinking Water Data

The drinking water residues were used in the latest dietary risk assessment conducted in 2010 

(D381050, D. Davis, 2010), which were provided by the Environmental Fate and Effects 

Division (EFED) in the memorandum: “Tier II Drinking Water Exposure Assessment for 

Fluopicolide and its Major Degradate, 2,6-Dichlorbenzamide (BAM) for Use on Potatoes, 

Carrots, Sugar Beets and Brassica (Cole) Leafy Vegetables” (R. Miller, D370764, 6/20/10) and 

incorporated directly into the dietary assessment. Water residues of 0.02414 ppm were 

incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and “water, 

indirect, all sources.” 

 

For the new use of fluopicolide on rotational corn, EFED has indicated that a new drinking water 

assessment (DWA) was not needed (Email communication with Michael Lowit, EFED

3/19/2013). 

IV. DEEM-FCID Program and Consumption Information

A fluopicolide chronic dietary exposure assessment was conducted using the DEEM-FCID, 

Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 
Fluopicolide Dietary Exposure and Risk Assessment DP Number: D407936

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linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99

years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

V. Toxicological Information

The immunotoxicity study submitted did not impact the endpoints selected for fluopicolide. The 

immunotoxicity NOAEL was 130 mg/kg/day based on decreased total spleen activity observed at 

1015 mg/kg/day. The toxicological doses and endpoints selected are the same as the endpoints 

used in the last assessment and are summarized in Table 4. 

Table 4. Summary of Toxicological Doses and Endpoints for Fluopicolide for Use in Dietary Exposure 

Risk Assessments

Exposure/

Scenario

Point of 

Departure

Uncertainty/

FQPA Safety 

Factors

RfD, PAD, Level of 

Concern Study and Toxicological Effects

Acute Dietary 

(All 

Populations)

An endpoint attributable to a single dose was not identified from the available data.

Chronic 

Dietary (All 

Populations)

Maternal 

NOAEL=20 

mg/kg/day

NOAEL =31.5 

mg/kg/day 

(co-critical 

study)

UFA=10x

UFH=10x

FQPA SF = 

1X

Chronic RfD = 

cRfD = 0.2 

mg/kg/day

cPAD = 0.2 

mg/kg/day

Developmental Toxicity Study in 

Rabbits

LOAEL (maternal) = 60 mg/kg/day 

based on death, abortions/premature 

deliveries, decreased food 

consumption and body weight gain.

Chronic Oncogenicity Study in 

Rats (co-critical study)

LOAEL = 109.4 mg/kg/day based 

on decreased body weight gain and 

increased thyroid weight and 

increased incidence of thyroid 

lesions.
Fluopicolide Dietary Exposure and Risk Assessment DP Number: D407936

Page 6 of 11

Table 4. Summary of Toxicological Doses and Endpoints for Fluopicolide for Use in Dietary Exposure 

Risk Assessments

Exposure/

Scenario

Point of 

Departure

Uncertainty/

FQPA Safety 

Factors

RfD, PAD, Level of 

Concern Study and Toxicological Effects

Cancer (oral, 

dermal, 

inhalation)

Classification: “Not Likely to be Carcinogenic to Humans”

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to 

mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL 

= no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = 

extrapolation from animal to human (interspecies). UFH = potential variation in sensitivity among members of the human 

population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (c = chronic). RfD = reference 

dose. 

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure and risk of the U.S. 

population and various population subgroups. The results reported in Table 5 are for the general 

U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50-99 years. 

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The established and newly proposed uses of fluopicolide resulted in an estimated exposure to the 

U.S. Population which is equivalent to 7.6% of the cPAD. The highest exposed subgroup is 

children 1 – 2 years of age with an estimated exposure equivalent to 12% of the cPAD. Results 

for all subpopulations are shown in the table below. 

Table 5. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Fluopicolide.

Population Subgroup

Acute Dietary Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population

N/A N/A

0.015176 7.6

N/A N/A

All Infants (<1 year old) 0.010336 5.2

Children 1-2 years old 0.024340 12

Children 3-5 years old 0.022836 11

Children 6-12 years old 0.014425 7.2

Youth 13-19 years old 0.011252 5.6

Adults 20-49 years old 0.014965 7.5

Adults 50-99 years old 0.015368 7.7

Females 13-49 years old 0.015252 7.6

*The subpopulation with the highest risk estimate is bolded.
Fluopicolide Dietary Exposure and Risk Assessment DP Number: D407936

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VII. Characterization of Inputs/Outputs

The chronic dietary exposure and risk analyses are based on tolerance-level residues, 100% crop 

treated assumptions, and default processing factors. Various refinements could be made to the 

assessments. However, as there are no risk estimates of concern, no refinements were 

incorporated.

VIII. Conclusions

The chronic dietary risk from the established and newly proposed uses of fluopicolide is not of 

concern for the U.S. population or any population subgroup. This assessment is not likely to 

underestimate risk. 

X. List of Attachments

Attachment 1. Chronic Dietary Input File

Attachment 2. Chronic Dietary Results File
Fluopicolide Dietary Exposure and Risk Assessment DP Number: D407936

Page 8 of 11

Attachment 1. Fluopicolide Chronic Dietary Input File

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FLUOPICOLIDE

Residue file: C:\DEEM\CalendexWWEIAFCID\FLUOPIC corn inadv CHRONIC F_W.R08

 Adjust. #2 used

Analysis Date 04-08-2013 Residue file dated: 04-08-2013/09:06:03

Reference dose (RfD) = 0.2 mg/kg bw/day

Comment:Addition of CG1, CG5B and rotational wheat uses to labels.

----------------------------------------------------------------------------------

Food Crop Residue Adj.Factors

EPA Code Grp Food Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------

0401005000 4A Amaranth, leafy 25.000000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.090000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.090000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.090000 1.000 1.000 

0401018000 4A Arugula 25.000000 1.000 1.000 

0902021000 9B Balsam pear 0.500000 1.000 1.000 

0101050000 1AB Beet, garden, roots 0.150000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 0.150000 1.000 1.000 

0200051000 2 Beet, garden, tops 15.000000 1.000 1.000 

0101052000 1A Beet, sugar 0.150000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.150000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 0.150000 1.000 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 0.150000 1.000 1.000 

0501061000 5A Broccoli 5.000000 1.000 1.000 

0501061001 5A Broccoli-babyfood 5.000000 1.000 1.000 

0501062000 5A Broccoli, Chinese 5.000000 1.000 1.000 

0502063000 5B Broccoli raab 18.000000 1.000 1.000 

0501064000 5A Brussels sprouts 5.000000 1.000 1.000 

0101067000 1AB Burdock 0.150000 1.000 1.000 

0501069000 5A Cabbage 5.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 18.000000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 5.000000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 5.000000 1.000 1.000 

0901075000 9A Cantaloupe 0.500000 1.000 1.000 

0402076000 4B Cardoon 25.000000 1.000 1.000 

0101078000 1AB Carrot 0.150000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.150000 1.000 1.000 

0101079000 1AB Carrot, juice 0.150000 1.000 1.000 

0103082000 1CD Cassava 0.090000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.090000 1.000 1.000 

0501083000 5A Cauliflower 5.000000 1.000 1.000 

0101084000 1AB Celeriac 0.150000 1.000 1.000 

0402085000 4B Celery 25.000000 1.000 1.000 

0402085001 4B Celery-babyfood 25.000000 1.000 1.000 

0402086000 4B Celery, juice 25.000000 1.000 1.000 

0402087000 4B Celtuce 25.000000 1.000 1.000 

0902088000 9B Chayote, fruit 0.500000 1.000 1.000 

0101100000 1AB Chicory, roots 0.150000 1.000 1.000 

0200101000 2 Chicory, tops 15.000000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.500000 1.000 1.000 

0302103000 3B Chive, fresh leaves 7.000000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 25.000000 1.000 1.000 

0502117000 5B Collards 18.000000 1.000 1.000 

1500120000 15 Corn, field, flour 0.020000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.020000 1.000 1.000 

1500121000 15 Corn, field, meal 0.020000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.020000 1.000 1.000 

1500122000 15 Corn, field, bran 0.020000 1.000 1.000 

1500123000 15 Corn, field, starch 0.020000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.020000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.020000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.020000 1.500 1.000 

1500125000 15 Corn, field, oil 0.020000 2.100 1.000 

1500125001 15 Corn, field, oil-babyfood 0.020000 2.100 1.000 
Fluopicolide Dietary Exposure and Risk Assessment DP Number: D407936

Page 9 of 11

1500126000 15 Corn, pop 0.020000 1.000 1.000 

0401133000 4A Cress, garden 25.000000 1.000 1.000 

0401134000 4A Cress, upland 25.000000 1.000 1.000 

0902135000 9B Cucumber 0.500000 1.000 1.000 

0401138000 4A Dandelion, leaves 25.000000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.090000 1.000 1.000 

0200140000 2 Dasheen, leaves 15.000000 1.000 1.000 

0802148000 8BC Eggplant 1.600000 1.000 1.000 

0401150000 4A Endive 25.000000 1.000 1.000 

0402152000 4B Fennel, Florence 25.000000 1.000 1.000 

0301165000 3A Garlic, bulb 7.000000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 7.000000 1.000 1.000 

0103166000 1CD Ginger 0.090000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.090000 1.000 1.000 

0103167000 1CD Ginger, dried 0.090000 1.000 1.000 

0101168000 1AB Ginseng, dried 0.150000 1.000 1.000 

1304175000 13D Grape 2.000000 1.000 1.000 

1304176000 13D Grape, juice 2.000000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 2.000000 1.000 1.000 

9500177000 O Grape, leaves 2.000000 1.000 1.000 

9500178000 O Grape, raisin 6.000000 1.000 1.000 

1304179000 13D Grape, wine and sherry 2.000000 1.000 1.000 

0901187000 9A Honeydew melon 0.500000 1.000 1.000 

0101190000 1AB Horseradish 0.150000 1.000 1.000 

0502194000 5B Kale 18.000000 1.000 1.000 

0501196000 5A Kohlrabi 5.000000 1.000 1.000 

0302198000 3B Leek 7.000000 1.000 1.000 

0401204000 4A Lettuce, head 25.000000 1.000 1.000 

0401205000 4A Lettuce, leaf 25.000000 1.000 1.000 

0502229000 5B Mustard greens 18.000000 1.000 1.000 

0802234000 8BC Okra 1.600000 1.000 1.000 

0301237000 3A Onion, bulb 7.000000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 7.000000 1.000 1.000 

0301238000 3A Onion, bulb, dried 7.000000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 7.000000 9.000 1.000 

0302239000 3B Onion, green 7.000000 1.000 1.000 

0401248000 4A Parsley, leaves 25.000000 1.000 1.000 

0101250000 1AB Parsley, turnip rooted 0.150000 1.000 1.000 

0101251000 1AB Parsnip 0.150000 1.000 1.000 

0101251001 1AB Parsnip-babyfood 0.150000 1.000 1.000 

0802270000 8B Pepper, bell 1.600000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 1.600000 1.000 1.000 

0802271000 8B Pepper, bell, dried 1.600000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 1.600000 1.000 1.000 

0802272000 8BC Pepper, nonbell 1.600000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 1.600000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 1.600000 1.000 1.000 

0103296000 1C Potato, chips 0.090000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.090000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.090000 1.000 1.000 

0103298000 1C Potato, flour 0.090000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 0.090000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.090000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.090000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.090000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.090000 1.000 1.000 

0902308000 9B Pumpkin 0.500000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 

0401313000 4A Radicchio 25.000000 1.000 1.000 

0101314000 1AB Radish, roots 0.150000 1.000 1.000 

0200315000 2 Radish, tops 15.000000 1.000 1.000 

0101316000 1AB Radish, Oriental, roots 0.150000 1.000 1.000 

0200317000 2 Radish, Oriental, tops 15.000000 1.000 1.000 

0502318000 5B Rape greens 18.000000 1.000 1.000 

0402322000 4B Rhubarb 25.000000 1.000 1.000 

0101327000 1AB Rutabaga 0.150000 1.000 1.000 

0101331000 1AB Salsify, roots 0.150000 1.000 1.000 
Fluopicolide Dietary Exposure and Risk Assessment DP Number: D407936

Page 10 of 11

0200332000 2 Salsify, tops 15.000000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 7.000000 1.000 1.000 

0401355000 4A Spinach 25.000000 1.000 1.000 

0401355001 4A Spinach-babyfood 25.000000 1.000 1.000 

0902356000 9B Squash, summer 0.500000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.500000 1.000 1.000 

0902357000 9B Squash, winter 0.500000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.500000 1.000 1.000 

0103366000 1CD Sweet potato 0.090000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.090000 1.000 1.000 

0402367000 4B Swiss chard 25.000000 1.000 1.000 

0103371000 1CD Tanier, corm 0.090000 1.000 1.000 

0801374000 8A Tomatillo 1.600000 1.000 1.000 

0801375000 8A Tomato 1.600000 1.000 1.000 

0801375001 8A Tomato-babyfood 1.600000 1.000 1.000 

0801376000 8A Tomato, paste 1.600000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 1.600000 1.000 1.000 

0801377000 8A Tomato, puree 1.600000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 1.600000 1.000 1.000 

0801378000 8A Tomato, dried 1.600000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 1.600000 14.300 1.000 

0801379000 8A Tomato, juice 1.600000 1.000 1.000 

0103387000 1CD Turmeric 0.090000 1.000 1.000 

0101388000 1AB Turnip, roots 0.150000 1.000 1.000 

0502389000 5B Turnip, greens 15.000000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.024140 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.024140 1.000 1.000 

0901399000 9A Watermelon 0.500000 1.000 1.000 

0901400000 9A Watermelon, juice 0.500000 1.000 1.000 

1500401000 15 Wheat, grain 0.230000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.230000 1.000 1.000 

1500402000 15 Wheat, flour 0.230000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.230000 1.000 1.000 

1500403000 15 Wheat, germ 0.240000 1.000 1.000 

1500404000 15 Wheat, bran 0.490000 1.000 1.000 

0103406000 1CD Yam, true 0.090000 1.000 1.000 

0103407000 1CD Yam bean 0.090000 1.000 1.000 
Fluopicolide Dietary Exposure and Risk Assessment DP Number: D407936

Page 11 of 11

Attachment 2. Fluopicolide Chronic Dietary Assessment Results

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FLUOPICOLIDE NHANES 2003-2008 2-day

Residue file name: C:\DEEM\CalendexWWEIAFCID\FLUOPIC corn inadv CHRONIC F_W.R08

 Adjustment factor #2 used.

Analysis Date 04-08-2013/09:06:45 Residue file dated: 04-08-2013/09:06:03

Reference dose (RfD, Chronic) = .2 mg/kg bw/day

COMMENT 1: Addition of CG1, CG5B and rotational wheat uses to labels.

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 Total exposure by population subgroup

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 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.015176 7.6%

Hispanic 0.014200 7.1%

Non-Hisp-White 0.015641 7.8%

Non-Hisp-Black 0.012625 6.3%

Non-Hisp-Other 0.017581 8.8%

Nursing Infants 0.006320 3.2%

Non-Nursing Infants 0.012130 6.1%

Female 13+ PREG 0.013881 6.9%

Children 1-6 0.022827 11.4%

Children 7-12 0.013536 6.8%

Male 13-19 0.010670 5.3%

Female 13-19/NP 0.011837 5.9%

Male 20+ 0.013907 7.0%

Female 20+/NP 0.016293 8.1%

Seniors 55+ 0.015247 7.6%

All Infants 0.010336 5.2%

Female 13-50 0.015235 7.6%

Children 1-2 0.024340 12.2%

Children 3-5 0.022836 11.4%

Children 6-12 0.014425 7.2%

Youth 13-19 0.011252 5.6%

Adults 20-49 0.014965 7.5%

Adults 50-99 0.015368 7.7%

Female 13-49 0.015252 7.6%

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