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                                                                    EXHIBIT 10.5


                         COMPUTER AND DATA PROCESSING
                              SERVICES AGREEMENT

     This COMPUTER AND DATA PROCESSING SERVICES AGREEMENT, dated as of May 11,
1999, (the "Effective Date") is by and between COLUMBIA INFORMATION SYSTEMS,
INC., a Tennessee corporation ("CIS") which is a wholly owned subsidiary of
Columbia/HCA Healthcare Corporation, a Delaware corporation ("Columbia/HCA"),
and LifePoint Hospitals, Inc., a Delaware corporation (together with its
successors and permitted assigns, hereinafter sometimes referred to as
"Customer").

                             W I T N E S S E T H:

     WHEREAS, CIS is in the business of providing certain computer and data
processing services as more fully set forth herein; and

     WHEREAS, Customer desires to purchase from CIS the services described in
this Agreement, and CIS is willing to provide such services to Customer, all on
the terms and conditions set forth herein;

     NOW, THEREFORE, in consideration of the premises and the mutual covenants
and obligations set forth herein, and for other good and valuable consideration,
the receipt and sufficiency of which are acknowledged, CIS and Customer agree as
follows:

     1.   Definitions.  The following terms shall have the meanings set forth
          -----------
below:

          (a)  APD or Adjusted Patient Days.  An amount equal to a particular
               ----------------------------
hospital's patient days times the dividend of the total patient revenue divided
by inpatient revenue.

          (b)  Affiliate. CIS as well as those entities, businesses, facilities,
               ---------
and enterprises (however and in whatever manner conducted) that are controlled
by, controlling, or under common control with it, including, without limitation,
all parent corporations and their respective subsidiaries and affiliates, joint
ventures, partnerships, limited liability companies and partnerships, hospitals,
free-standing centers, home health agencies, surgery centers, physician
practices, syndications, medical laboratories, medical records processing
facilities, medical supply sellers, pharmacies, insurance providers, health care
providers, and managed care entities, together with any and all entities and
businesses to which CIS or any of the above described entities provide
management services, information processing services or purchasing services.

          (c)  CIS Software.  The software listed in Exhibit B hereto and
               ------------
identified as being owned by CIS, including Enhancements, upgrades and custom
development.

          (d)  Communication Lines.  The telephone communication and diagnostic
               -------------------
lines for data transmission with the Data Center and/or CIS, whether dedicated
or not.

          (e)  Consumer Price Index.  The Medical component of the United States
               ---------------------
Consumer Price Index published by the United States Department of Labor, All
Cities Average (1986=100) or such other successor index the parties shall
designate.

                                       1
<PAGE>

          (f) Customer Data.  Any data owned or held in custody by Customer,
              -------------
including without limitation, financial data, patient medical record data or
patient identification data used or transmitted to the Data Center by Customer
in connection with its purchase of the Services under this Agreement.

          (g) Data Center.  The CIS Data Center(s) located in Nashville,
              -----------
Tennessee and/or any of CIS's Regional Data Centers containing computer
processing equipment and the Software used by CIS to provide the Services, or
such other facilities as CIS may establish from time to time.

          (h) Equipment.  The computer hardware located at the Facility or
              ---------
Facilities.

          (i) Facility/Facilities.  The hospitals and other healthcare providers
              -------------------
owned by Customer and listed in Exhibit A hereto.

          (j) Hospital Resource Guide.  This term is defined in Section 5(a).
              -----------------------

          (k) Initial Term.  The seven (7) year period commencing on the
              ------------
Effective Date.

          (l) Koala System.  The proprietary intranet network currently provided
              ------------
by CIS for use by affiliated facilities to obtain information relevant to day-
to-day operations.

          (m) Monthly Processing Fees.  The fees for monthly service under this
              -----------------------
Agreement as more fully set forth in Section 2 and Exhibit B.

          (n) Parties.  Collectively the individual entities which execute this
              -------
Agreement.

          (o) Software.  The computer software identified in Exhibit B hereto as
              --------
either CIS Software or Third Party Software which is used by CIS in providing
the Services to Customer, including Enhancements, upgrades and custom
development.

          (p) Services.  The installation, support, training, maintenance, data
              --------
processing and other services provided to Customer by CIS pursuant to this
Agreement, as set forth in Exhibit C hereto.

          (q) Systems.  The Equipment and Software functioning together,
              -------
located at one or more Facilities.

          (r) Third-Party Software.  The software indicated in Exhibit B hereto
              --------------------
as being licensed to CIS by a third-party provider.

          (s) Wide Area Network.  The proprietary wide area network currently
              -----------------
provided by CIS for use by affiliated facilities to deliver CIS products and/or
services (for example, e-mail, host application access, file transmission, Koala
System access).

                                       2
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     2.   Services, Systems, Data, Payment.
          --------------------------------

          (a) CIS shall provide, and Customer shall purchase from CIS, the
Services and/or licenses to the Software described in the exhibits hereto, upon
the terms and subject to the conditions of this Agreement, for the benefit of
the Facility or Facilities.

          (b) CIS shall designate certain coding and naming conventions for the
form of Customer Data and shall provide to Customer the coding requirements for
transmitting Customer Data to the Data Center and the treatment given to
different account and processing codes used by CIS.  CIS reserves the right to
make changes in operating procedures, coding and naming conventions, hardware
and network configurations and applications and systems programming.  CIS shall
provide Customer with thirty (30) days notice of such changes.  Customer shall
be responsible for, and bear the cost of, (i) coding and transmitting Customer
Data to the Data Center, (ii) supervising the conversion of its financial data
into a form that can be processed by CIS, (iii) determining whether it has
complied with applicable accounting practices, (iv) determining whether it has
complied with applicable state and federal regulations governing financial
reporting obligations, (v) verifying the accuracy of Customer Data generated by
it and/or CIS and (vi) maintaining prudent internal controls of reports and
Customer Data.

          (c) If Customer requests that CIS correct or reprocess data files
because of erroneous input data or output records, CIS will use its reasonable
best efforts to perform such correction and reprocessing.  If possible, Customer
shall request any correction or reprocessing within seventy-two (72) hours after
production of the reports.  If correction or reprocessing is requested because
of an error attributable to CIS or the negligence of CIS, there shall be no
charge for such rerun, provided that the request for reprocessing is made within
seventy-two (72) hours after production of the erroneous report.  In the event
that the error is attributable to Customer's erroneous input data or output
records, or Customer requests reprocessing after such seventy-two (72) hour
period, CIS will determine whether it can perform the reprocessing and, if it
can perform the reprocessing, will provide a cost estimate to Customer for such
reprocessing services.  Following mutual agreement on the cost, CIS will perform
the reprocessing services.  If the parties are unable to agree on the cost for
the reprocessing services, CIS shall not perform such services.

          (d) Customer shall pay CIS on behalf of the Facilities for the
Services rendered and licenses granted in accordance with the terms and subject
to the conditions contained herein and in the Exhibits hereto.  Prices are
subject to change as set forth herein and in the Exhibits hereto.

          (e) In the event that Customer makes a written request for the
performance of on-site Services by CIS, Customer shall pay the reasonable and
customary travel expenses of CIS personnel performing such Services for
Customer, in accordance with CIS's standard business travel policies.

          (f) Unless otherwise provided herein, payment is due within thirty
(30) days of the date of receipt of an invoice.  Without limiting CIS's rights
hereunder, any amounts not paid within thirty (30) days of the due date shall be
subject to a late charge equal to the lesser of twelve percent (12%) per annum
or the maximum amount allowed by applicable law; provided, however, that no late
charge shall apply with respect to amounts reasonably disputed by Customer if
written

                                       3
<PAGE>

notice of such dispute is given to CIS within fourteen (14) days of receipt of
invoice; provided, however, that the interest on any disputed charges that are
ultimately resolved against Customer shall accrue from the date payment would
have otherwise been due. Disputes under this Section will be resolved pursuant
to the procedure set forth in Section 12(f).

          (g)  Customer's Monthly Processing Fees are indicated in Exhibit B.
The Monthly Processing Fee is due and payable within thirty (30) days of receipt
of an invoice.  Monthly Processing Fees shall be calculated as set forth in
Exhibit B.

          (h)  On each anniversary date of this Agreement, CIS shall review and,
if necessary, adjust the Monthly Processing Fees of the Customer for the prior
twelve months as follows:

               1)   If, during the prior twelve month period, the actual total
                    system fees charged to Customer under this Agreement fall
                    below an amount equal to seventy-five percent (75%) of the
                    total system fees set forth in Exhibit E, CIS may charge
                    Customer the difference in fees actually charged and such
                    seventy five percent (75%) figure.

               2)   Added/Divested Facilities - The parties acknowledge that
                    Customer may add or divest Facilities from time to time
                    during the term of this Agreement.  CIS shall provide
                    professional services in connection with added and divested
                    Facilities as described and for the fees set forth in
                    Exhibits C and D.  For divested Facilities Customer's
                    Monthly Processing Fees shall be reduced beginning on the
                    date of such Facility's last use of the System.  For added
                    facilities, Monthly Processing Fees shall be increased
                    beginning on the date of such Facility's first use of the
                    System.

          (i)  No more than once annually, CIS may increase any fees in this
Agreement or the Exhibits by an amount equal to the percentage increase in the
Consumer Price Index plus up to three percent (3%).  In addition, CIS may at any
time pass through to Customer any fee increases actually charged to CIS for
Third Party Software.

          (j)  At each anniversary date of the Agreement, if the total fees paid
by Customer are more than one hundred and fifty percent (150%) of the fees paid
in the previous year, Customer shall be entitled to a credit on CIS's next
annual period fees equal to fifteen percent (15%) of such increase.  For
purposes of this calculation, the first year shall be compared to the fees set
forth in Exhibit E.

     3.   New Services and Systems; Updates.
          ---------------------------------

          (a)  From time to time, CIS will offer new Services or Systems which
are offered to its own facilities to Customer, which Customer may purchase in
its discretion.  Certain new Services and/or Systems may require Customer to pay
additional fees, purchase additional Equipment or Communications Lines or
license additional software.

                                       4
<PAGE>

          (b)  From time to time CIS may update the Software or provide Updates
received from the licensor for Third Party Software.  As used herein, the term
"Update" means any fix, change or modification which affects the operating
performance or efficiency of the Software, but does not alter the basic
functions that it performs.  At the request of CIS, Customer will discontinue
use of the then-current version of the Software and, within sixty (60) days of
its receipt of the updated version (including receipt of all documentation
relating thereto), substitute therefor the updated version of the Software in
accordance with the Hospital Resource Guide.  In the event that Customer fails
to update the Software, CIS shall not be required to maintain or support such
Software.

          (c)  From time to time CIS may enhance the Software System or provide
Enhancements received by it for Third Party Software.  As used herein, the term
"Enhancement" means any new feature or function which improves the operating
performance or efficiency of the Software and/or new Equipment or infrastructure
standards.  At CIS's option, fees for Enhancements may be charged to Customer.

          (d)  CIS may, in its sole discretion, migrate to a new System(s) which
shall be offered to Customer by CIS at a price to be determined by CIS at the
time of such offering.  If the Customer elects not to purchase such System(s),
CIS shall continue to support the current system utilized by Customer at prices
to be determined by CIS.  The Customer shall make such election within 60 days
after CIS provides an offer describing such System(s) and specifying the pricing
for same.

     4.   Software and Wide Area Network; Prohibited Uses.
          -----------------------------------------------

          (a)  The use of the CIS Wide Area Network is expressly restricted to
accessing the Software, Customer Data and Services provided by CIS in the manner
described in user documentation and in CIS policy and standards manuals.
Customer acknowledges that the Wide Area Network provided by CIS to support
Customer's operation is proprietary. The Customer shall comply with the Hospital
Resource Guide, which describes the responsibilities and duties of CIS and the
Customer in respect of the Network.  Customer shall not reverse engineer the
Wide Area Network in order to obtain access to proprietary data or for any other
purpose not specifically authorized herein.

Customer shall not perform any of the following activities or any other
activities not conforming to the stated use of the Wide Area Network and agrees
to provide reasonable notification to employees at the Facilities that they
shall not:

     .    Place any equipment on the Wide Area Network for the purpose of
          recording CIS electronic communications or deciphering the content and
          structure of CIS electronic communications;

     .    Access any piece or segment of the CIS Wide Area Network of computing
          infrastructure via any telecommunications utility, for example,
          without limitation, Telnet and TCP/IP, other than as specified in CIS
          documentation and in a manner consistent with the documented access
          policy and procedures for CIS Application Software and Services; or

                                       5
<PAGE>

     .    Take any other action which would have the effect of impeding or
          prohibiting normal operation of the Wide Area Network.

In addition to the foregoing, Customer will obtain approval from CIS prior to
adding any additional equipment or connections to the Wide Area Network, which
approval will not be unreasonably withheld.

     .    Customer acknowledges and agrees that access to the CIS Wide Area
          Network may be temporarily terminated at CIS's sole discretion (with
          notice to Customer) under the following circumstances:

     .    Customer engages in unauthorized use of the Wide Area Network as
          indicated in this Agreement;

     .    A Customer site generates a condition that interferes with the normal
          operation of the Wide Area Network, for example, without limitation, a
          hardware problem generating excessive network traffic or conflicting
          IP addresses are added to the network; or

     .    A non-Customer site generates a condition that interferes with the
          normal operation of the Wide Area Network and a Customer site is taken
          down as part of the process of identifying and remediating the
          problem.

With respect to any event caused other than by a malicious act of Customer or by
the unauthorized use of the Wide Area Network, CIS will use its reasonable best
efforts to ensure that access to the Wide Area Network is restored in a timely
manner.  With respect to any event caused by a malicious act or the unauthorized
use of the Wide Area Network, access will be restored when CIS has received
reasonable assurance from Customer that repeat acts or unauthorized use will not
occur.  CIS will determine reasonable assurance in its sole discretion.

          (b)  Subject to the terms in each of the licenses for Third-Party
Software granted to CIS and as set forth below, CIS grants to Customer, for the
Initial Term and any renewal term of this Agreement, a non-transferable, non-
exclusive license to use the  Software as contemplated in this Agreement.  In
this context, "use" includes use by Customer and medical service providers
accessing directly or remotely the Software in the manner permitted by such
Software and CIS policy and standards.

          (c)  Customer shall have no rights to the Software or to information
obtained from the Wide Area Network or the Koala System not expressly granted
under this Agreement.  Without limiting the generality of the foregoing,
Customer shall have no right to (i) alter the Software, (ii) create derivative
works, (iii) distribute or sublicense the Software copies to third parties, (iv)
incorporate additional software into the Software at the operating system or any
other level, (v) incorporate the Software into any publicly available data base
or (vi) reproduce the Software without CIS's prior written consent, which
consent will not be unreasonably withheld.

          (d)  Nothing herein shall be deemed to grant to Customer any ownership
interest in the Software.

                                       6
<PAGE>

          (e)  Customer shall not use the Software for any purpose other than as
specifically permitted by this Agreement.  Customer shall not alter or delete
any copyright or other proprietary notices in the Software.

          (f)  Customer shall have the right to copy documentation to support
use of the Software.

     5.   Equipment, Installation.
          -----------------------

          (a)  If Customer purchases and installs Equipment and Communication
Lines (other than Equipment and Communication Lines currently installed at each
Facility as of the date hereof), then Customer shall comply with the parameters
set forth below and the installation guidelines in the Hospital Resource
Guidelines distributed by CIS from time to time (the "Hospital Resource Guide").
The Hospital Resource Guide describes the responsibilities and duties of CIS
and Customer with respect to Communication Lines.  Selection of the most
appropriate installation site for any additional Equipment and Communication
Lines within the Facility is Customer's responsibility.  At Customer's request,
CIS will assist Customer in identifying installation sites, provided that in
giving such assistance, CIS makes no representation that any installation site
is the appropriate site for Equipment.  Proper installation may require the
removal of walls or other alterations to the premises.  Customer shall be
responsible for any costs incurred in modifying the premises to accommodate the
installation of any Equipment or Communication Lines.  Any damage to Customer's
Equipment and Software resulting from inadequate or incomplete site preparation
may not be covered by applicable maintenance agreements.

          (b)  With respect to any purchases and installations of new Equipment
and Communication Lines, Customer shall perform the following to ensure adequate
site preparation:

               (1)  When required by CIS, provide the CIS representative with
          appropriate drawings indicating:

                    i.   the location and lay-out of the installation site;

                    ii.  the location of existing and proposed site wiring
               (power and communications) and the paths and lengths thereof; and

                    iii. the location of other equipment capable of generating
               electrical noise, electromagnetic interference, heat, etc.;

               (2)  Make alterations to the premises necessary to meet wiring
          and other site requirements;

               (3)  Provide and install all communication cables, wall jacks,
          special connectors and associated hardware;

               (4)  Install all necessary power distribution boxes, conduits,
          grounds, lightning protection and associated hardware;

               (5)  Install all required auxiliary power protection and air
          conditioning;

                                       7
<PAGE>

               (6)  Provide required storage or service areas;

               (7)  Ensure the environmental requirements of the Equipment are
          met;

               (8)  Provide floor coverings and environmental systems that
          control static electricity build-up and discharge; and

               (9)  Comply with all applicable federal, state and municipal
          laws, codes and regulations (including, without limitation,
          electrical, building, safety and health laws).

          Clauses (1) through (9) above set forth only the minimum standards,
are not intended to be comprehensive and do not modify the obligations of
Customer described in the Hospital Resource Guide or the obligation of Customer
to follow the instructions and recommendations of CIS relating to the use of the
Software and the Systems.

     6.   Maintenance and Support Services.
          --------------------------------

          (a)  CIS shall provide maintenance services for the Equipment through
CIS's third-party maintenance providers and the CIS Depot Maintenance as set
forth in Exhibit B.  Customer shall have the right to use an alternative
Equipment maintenance provider, provided that at least sixty (60) days' prior
written notice is given to CIS and CIS, in its reasonable discretion, approves
such proposed alternative Equipment maintenance provider.  In such cases,
responsibility for vendor performance and system availability delivered via this
Equipment will transfer solely to Customer.

          (b)  Subject to availability, CIS will provide additional on-site
installation support to Customer at CIS's hourly rates then in effect.  In
exchange for the software maintenance fees set forth in Exhibit B hereto, CIS
will provide customer assistance through its customer support center in a manner
consistent with that provided to a Facility prior to the Distribution Date.

          (c)  CIS shall not be required to provide maintenance or support
Services to any portion of the Software that has been altered by Customer
(without the prior written approval of CIS) if such alteration adversely affects
CIS's ability to provide such Services, as determined by CIS in its reasonable
discretion.

          (d)  Customer may utilize other vendors of computer systems requiring
interface with the Systems provided hereunder and, upon prior written notice to
and approval by CIS (which approval will not be unreasonably withheld), CIS
shall cooperate with such vendors or Customer in the development and maintenance
of necessary interfaces with the Systems, provided that nothing herein shall
require CIS to provide programming support in respect of such interfaces.  CIS
will work with a third party vendor selected by Customer to supply, implement
and test any CIS existing interface transactions on a time and materials basis.
CIS will also adapt existing interfaces to add existing accessible data elements
to transactions on a time and materials basis.  CIS will review data elements
that do not exist on CIS systems for potential additions on a time and materials
basis but retains the right to reject such additions in its sole discretion.
All costs and expenses incurred by CIS pursuant to this paragraph shall be
reimbursed by Customer at the then-current CIS billing rates for time and
materials.  Except as provided in this paragraph, CIS shall

                                       8
<PAGE>

have no obligation to provide Services for systems provided by a person other
than CIS or a vendor preferred by CIS. All such Services shall be Customer's
responsibility and at Customer's cost.

          (e) The provision of Services may result in the disclosure to CIS of
third-party confidential or proprietary information in possession of Customer
and in which CIS has no rights.  Customer shall indemnify and hold harmless CIS
from the failure of Customer to obtain any third-party consents that may be
required so that CIS may provide the Services.

          (f) In the event Customer requires services beyond those provided in
this Agreement, or as a result of Customer's use of  Software or Systems other
than in conformity with applicable specifications, then to the extent that CIS
agrees to provide additional services, the services shall be provided at the
then-current CIS billing rates for time and materials.

          (g) CIS agrees to make its Wide Area Network available to Customer for
access and use only at Facilities listed in Exhibit A hereto as amended from
time to time as acquired by Customer.  CIS agrees to make the Information
Systems portion of Koala System available to Customer for access by Facilities
in a manner consistent with the use prior to the Distribution Date.  Customer
agrees that any information obtained by a Facility from the Koala System, to the
extent such information is not otherwise publicly available, will not be
disclosed to third parties or used other than as required in the operation of
the Facility.

          (h) CIS shall maintain Disaster Recovery Plans for critical systems
and a named disaster recovery administrator to manage the plan.  The purpose of
the disaster recovery plans will be to provide a cost-effective means to reduce
the amount of the time required to restore system functionality in the event of
a catastrophic failure at a single data center versus completely rebuilding the
computing infrastructure.  These plans will be periodically tested, and the
result made available to customer upon request.

     7.   Customer Linkage. The CIS Director of Information Systems ("DIS") will
          -----------------
continue to support the Customer locally and provide account management in a
manner consistent with that used to support facilities owned by CIS's corporate
parent.  The DIS and Customer will conduct a joint effort to define overall
Customer objectives and develop an information technology plan whereby CIS can
assist in meeting these objectives.  This process will allow for long-range
planning and budgeting for system growth, system requirements and resource
planning to meet stated objectives.  Customer shall be entitled to make a one-
time designation of either its CEO or COO to participate in the Information
Systems Steering Committee (ISSC) and shall be entitled to designate one
Facility representative to participate in each of the User Review Groups (URGs)
designed to assist CIS in identifying and ranking system updates and
enhancements.  There is no fee involved in participating in the URGs.  Expenses
involved in participating in the URGs shall be borne by Customer.

     CIS and Customer have defined non-binding Service Level Objectives ("SLOs")
to serve as a benchmark for CIS and Customer to periodically assess together the
functioning and satisfaction level derived from the outsourcing relationship.
SLOs are defined in Exhibit F.  It is understood that the definition of the SLOs
may be changed over time as mutually agreed by the

                                       9
<PAGE>

parties. Customer and CIS agree to comply with their respective responsibilities
as set forth in Exhibit G.

     8.   Confidentiality; Proprietary Rights.
          -----------------------------------

          (a) Data and materials of Customer stored by CIS shall remain the
property of Customer.  CIS shall provide such data and materials to Customer
within thirty (30) days of the receipt of Customer's request for such data or
materials.  Notwithstanding the foregoing, CIS shall maintain copies of Customer
Data for such periods of time as are required under this Agreement and for such
other periods of time as CIS, in its sole discretion, shall deem to be
advisable.

          (b) CIS warrants that it will retain all information belonging to
Customer in confidence and will neither use it nor disclose it to anyone without
the prior written consent of Customer.  Notwithstanding the foregoing, to the
extent that CIS is requested (by oral questions, interrogatories, requests for
information or documents, subpoena, civil investigative demand or similar
process) to disclose any information required to be kept confidential pursuant
to this Section 8, CIS agrees to maintain the confidentiality of such
information and to provide prompt notice to Customer, so that Customer may seek
an appropriate protective order or waive compliance by CIS with this Section 8.
If, in the absence of a protective order or the receipt of a waiver by Customer
hereunder, CIS is, nonetheless, in the reasonable written opinion of counsel,
legally required to disclose such information, CIS may disclose such
information, and CIS shall not be liable pursuant to this Section 8; provided,
that (i) CIS shall furnish only that portion of the information which it is
advised by counsel to disclose and (ii) CIS shall exercise its reasonable
efforts to obtain assurance that confidential treatment will be accorded to the
disclosed portion of the information. Moreover, nothing in this Agreement shall
prevent CIS from disclosing confidential information in any proceeding in which
it is in an adversarial position to Customer.

          (c) CIS will provide, and Customer agrees to comply with, reasonable
security measures and procedures designed to (i) limit access to the Software
and Customer Data to authorized personnel and (ii) minimize the possibility of
unauthorized access.  CIS reserves the right to issue and change security
procedures from time to time with notice to Customer, including passwords and
user identification numbers, which may require acquisition and installation of
additional applications, tools and/or equipment at Customer cost.  Customer
shall be responsible for safeguarding and controlling the use of passwords and
user identification numbers assigned by CIS.

          (d) During the term of this Agreement and thereafter, Customer shall
keep confidential all information pertaining to the use or operation of the
Software, disclosing such information only to those persons who need to have
such information in order to utilize the Systems.  Each party shall immediately
inform the other of any suit or action instituted against it based upon a claim
that the Software or any portion thereof infringes a patent, copyright, trade
secret or other proprietary right of a third party.

          (e) The Software may include proprietary and copyrighted data or
programs of third parties.  Such data and programs are supplied to Customer
pursuant to express authority of such third parties, subject to (i) the terms
and conditions of the rights granted to CIS and (ii) CIS obtaining required
consents from licensors of Third-Party Software, and may be subject to

                                       10
<PAGE>

revocation.  In the event of revocation, CIS shall use its reasonable best
efforts to provide software with similar functionality as soon as reasonably
possible, it being understood that if additional cost is incurred, such
additional costs shall be paid by Customer.  Neither Customer, Facility, CIS nor
such licensor shall be liable to the other for damages, indirect, consequential
or special, that may result from the use of the Software by Customer or any
employee or agent thereof.

     9.   Warranties.  Subject to the limitations of this section and Section 10
          ----------
hereof and subject to such limitations as are expressly provided elsewhere in
this Agreement, CIS warrants that the Services provided by it hereunder shall be
performed, in all material respects, in a professional, timely and workmanlike
manner and shall be as described in this Agreement and the exhibits hereto.  In
addition, CIS warrants that, to the best of its knowledge, it has the legal
right to license or sublicense to Customer the Software and to perform the
Services.  CIS makes no warranties of any kind in connection with the
Communication Lines or services provided by any telephone company.  CIS makes no
warranties of any kind with respect to the Equipment.  Customer must look solely
to the manufacturer of such Equipment for any warranties relating thereto.

          (a) Ownership and Quiet Enjoyment.  CIS hereby warrants and represents
              -----------------------------
to Customer that CIS owns all right, title and interest in and to the Software,
Documentation and other proprietary material provided under this Agreement, or
otherwise has the right to grant to Customer the license to use  same as set
forth in this Agreement without violating or infringing upon any rights of any
third party and without breach of any third-party license to CIS, and to the
knowledge of CIS there is currently no actual or threatened suit by any third
party based on an alleged violation, infringement or breach by CIS.  CIS shall
not interfere with use of the Software and the Documentation in accordance with
this Agreement shall not be disturbed or interfered with during the continuation
of the license granted hereunder.

          (b) Software Operation.  The Software shall perform in accordance with
              ------------------
the Documentation; provided, however, if a Customer makes an unauthorized
modification to the Software, then this warranty shall terminate.

          (c) Performance Standards.  Each of CIS's employees, agents or
              ---------------------
representatives assigned to perform services hereunder shall have the proper
skill, training and background so as to be able to perform in a competent and
professional manner and all work will be so performed in a manner compatible
with Customer's business operations at its premises.

          (d) Virus. CIS warrants and represents that the Software provided
              -----
under this Agreement, at the time it is supplied, is completely free of any
virus, rouge program, time bomb, turn off instruction, or any other device
however characterized that is potentially damaging to the materials provided,
other programs, data, computer hardware, computer software, telecommunications
equipment or any other material or device in any manner whatsoever.

          (e) Alpha/Beta Site.  CIS warrants and represents that Customer is not
              ---------------
an alpha or a beta site for the Software and will not be for any new services
unless the consent of Customer's Chief Information Officer or Chief Executive
Officer is obtained.

                                       11
<PAGE>

          (f)  Regulatory Updates. CIS shall use commercially reasonable efforts
               ------------------
to develop modifications to the System to comply with changes in United States
federal regulatory requirements.  Such federal regulatory modifications will be
developed at no charge so long as Customer is covered under the terms of this
Agreement.  At Customer's request, CIS shall use all commercially reasonable
efforts to modify the System to comply with state and local regulatory
modifications on a "Fair Share Basis".  As used herein "Fair Share Basis" means
charges will be incurred on a time and material basis with costs divided by the
total number of CIS Customers affected by a given modification).

     THE FOREGOING WARRANTIES ARE THE EXCLUSIVE WARRANTIES UNDER THIS AGREEMENT
AND ARE IN LIEU OF ALL OTHER WARRANTIES, EXPRESS, IMPLIED OR STATUTORY,
INCLUDING, WITHOUT LIMITATION, ANY WARRANTY OF MERCHANTABILITY OR FITNESS FOR A
PARTICULAR PURPOSE.  CUSTOMER EXPRESSLY WAIVES AND SHALL NOT MAKE ANY CLAIM OF
ANY KIND AGAINST CIS ARISING OUT OF THE FAILURE OF PERFORMANCE OF ANY PIECE OF
EQUIPMENT, OF CIS SOFTWARE OR THIRD-PARTY SOFTWARE, OR OF THE COMMUNICATION
LINES, OR OUT OF THE BREACH OF ANY WARRANTY PROVIDED BY THE MANUFACTURER OF SAID
EQUIPMENT OR BY THE TELEPHONE COMPANY.  CIS SHALL PASS THROUGH TO CUSTOMER THE
BENEFITS OF ANY EXPRESS WARRANTIES RELATING TO THE EQUIPMENT, AND SHALL ASSIST
CUSTOMER WITH ANY SUCH WARRANTY CLAIMS.

     CIS makes no warranty or guaranty, and hereby expressly disclaims all
warranties, expressed or implied, as to the Equipment and/or Systems at the
Facilities being Year 2000 compliant.  CIS, however, acknowledges the need for
all Software to be Year 2000 compliant and is currently making efforts in a
professional, timely and workmanlike manner that it deems reasonable to address
the Year 2000 compliance issues with the Software.  Addressing specific Year
2000 compliance issues may result in software product replacement, or
termination of the software product, service and support per the provisions of
this Agreement.  How to address Year 2000 issues will be determined by CIS in
its sole discretion.

     CUSTOMER ACKNOWLEDGES THAT IT IS CUSTOMER'S SOLE OBLIGATION TO ENSURE THAT
ALL EQUIPMENT AND SYSTEMS AT THE FACILITIES USED TO PROCESS CUSTOMER DATA IS
YEAR 2000 COMPLIANT AND THAT TO THE EXTENT ANY ASSISTANCE IS PROVIDED BY CIS TO
OBTAIN YEAR 2000 COMPLIANCE, SUCH SERVICE IS PROVIDED WITHOUT ANY WARRANTY
WHATSOEVER. CUSTOMER AGREES TO RELEASE CIS FROM ANY CLAIMS OR ACTIONS IT MAY
HAVE NOW OR IN THE FUTURE AGAINST CIS RELATING TO YEAR 2000 COMPLIANCE WITH
RESPECT TO SUCH EQUIPMENT OR SYSTEMS OR ANY COMPUTER SOFTWARE OR HARDWARE USED
BY CUSTOMER, AND CUSTOMER AGREES TO DEFEND, INDEMNIFY AND HOLD CIS AND ITS
AFFILIATES HARMLESS FROM ANY CLAIM OR ACTION BASED ON ANY INJURY OR DAMAGES
SUFFERED BY CUSTOMER OR ANY THIRD PARTY AS A RESULT OF ANY COMPUTER SOFTWARE OR
HARDWARE USED BY CUSTOMER NOT BEING YEAR 2000 COMPLIANT.  A product is Year 2000
compliant/ready when it can accurately and unambiguously process (including,
without limitation, compare, calculate, manipulate, sequence, display and
exchange data with other systems) data containing time and/or dates prior to, at
and

                                       12
<PAGE>

after the Year 2000 without error or interruption, and the product operates
properly and in conformance with applicable specifications, without any
detrimental effect on patient care, continuously, before, at and after the Year
2000.

     10.  Limitation of Liability.
          -----------------------

          (a) Neither party shall be liable to the other for any failure or
delay in the performance of its obligations under this Agreement if such failure
or delay arises out of a cause beyond the reasonable control of such party. Such
causes may include, without limitation, acts of God, a public enemy, civil or
military authority, fires or other catastrophes, strikes, delays in
transportation, riots or war. Failure to comply with the terms of this Agreement
or the Hospital Resource Guide may result in serious damage to Customer's
Equipment, Software and Facilities. CIS shall have no liability for damage
resulting from Customer's failure to comply with the terms of this Agreement,
any Hospital Resource Guide or any other instructions provided by CIS to
Customer. Should the Software be made the subject of any claim alleging
infringement of any patent, copyright, trade secret, trademark or other
intellectual property rights of any third person, CIS's sole liability shall be,
at its option, to procure the right to use the Software free of such liability
or to replace or modify the Software to make it non-infringing while maintaining
equivalent functionality. No person providing data or programs in the Software
shall be deemed thereby to be engaging in the practice of medicine or dispensing
medical services.

     IN THE EVENT OF DELAYS, ERRORS OR OMISSIONS IN PROCESSING OR IN PROVIDING
OR FAILING TO PROVIDE ANY OTHER SERVICES PROVIDED BY CIS HEREUNDER, CIS SHALL
USE ITS REASONABLE BEST EFFORTS TO CORRECT SUCH ERRORS OR OMISSIONS, TO MAKE
SUCH SERVICES AVAILABLE AND/OR RESUME PERFORMING SUCH SERVICES AS PROMPTLY AS
REASONABLY PRACTICABLE AND AT NO ADDITIONAL CHARGE, PROVIDED THAT NOTICE OF SUCH
ERROR OR OMISSION IS GIVEN WITHIN SEVENTY TWO (72) HOURS AFTER PRODUCTION OF ANY
REPORT. OTHERWISE, CIS SHALL HAVE NO OTHER OBLIGATIONS OR LIABILITY FOR SUCH
ERRORS, DELAYS OR OMISSIONS. IN NO EVENT SHALL EITHER PARTY BE LIABLE TO THE
OTHER FOR INDIRECT, SPECIAL, PUNITIVE, EXEMPLARY, INCIDENTAL OR CONSEQUENTIAL
DAMAGES OF ANY KIND ARISING OUT OF THE PERFORMANCE OR BREACH OF THIS AGREEMENT,
INCLUDING, WITHOUT LIMITATION, LOST PROFITS, LOSS OF DATA OR BUSINESS
INTERRUPTION. FURTHERMORE, EACH PARTY'S LIABILITY TO THE OTHER FOR ANY OTHER
DAMAGES CAUSED BY OR RESULTING FROM THE PERFORMANCE OR BREACH OF THIS AGREEMENT,
WHETHER IN TORT, CONTRACT OR OTHERWISE, SHALL BE LIMITED IN EACH CASE TO $50,000
PER FACILITY AND $100,000 IN THE AGGREGATE, WHICH SUMS SHALL BE APPLIED AS A
CREDIT AGAINST FEES.

          (b)  Notwithstanding the foregoing, the limitations of liability shall
not apply to (i) the indemnification obligations set forth in this Section 10 or
(ii) breach of the confidentiality provisions set forth in Section 8 hereof.

          (c) Customer shall indemnify and hold harmless CIS from and against
any loss, damage or liabilities (including, without limitation, attorneys' fees)
resulting from claims,

                                       13
<PAGE>

actions or lawsuits ("Losses") asserted by or on behalf of third parties or
which result from governmental action or are otherwise asserted against CIS only
to the extent that such Losses are determined by a judgment of a court that is
binding, final and not subject to review on appeal to have resulted primarily
from Customer's fraud, willful misconduct, negligence or breach of the
confidentiality provisions set forth in Section 8 hereof. CIS will indemnify and
hold harmless Customer from and against any Losses asserted by or on behalf of
third parties or which result from governmental action or are otherwise asserted
against Customer only to the extent that such Losses are determined by a
judgment of a court that is binding, final and not subject to review on appeal
to have resulted primarily from CIS's fraud, willful misconduct, negligence or
breach of the confidentiality provisions set forth in Section 8 hereof.

     11.  Term; Termination; Breach.
          -------------------------

          (a)  This Agreement shall become effective as of the Effective Date
and shall continue during the Initial Term, unless earlier terminated pursuant
to the provisions of this Section 11, in which event this Agreement shall
terminate upon the effective date of termination, as described in paragraph (b)
below.

          (b)  This Agreement, and the Services and Systems provided hereunder,
may be terminated prior to the expiration of the Initial Term only as follows:

               (1)  with cause (as described in paragraph (c) below), by the
          giving of written notice by either party, in which event such
          termination shall be effective sixty (60) days after the giving of
          such notice; or

               (2)  in the event either party files a proceeding, or has an
          order for relief entered with respect to it, under any federal or
          state bankruptcy laws now or hereafter in effect, by the giving of
          written notice by the other party, in which event such termination
          shall be effective sixty (60) days after the giving of such notice.

          (c)  In the event of a breach of any obligation or covenant under this
Agreement by Customer or CIS, other than the obligation to pay money (other than
payments disputed by Customer or CIS in good faith), the party not in breach may
give the party in breach written notice of the specifics of the breach and the
party in breach shall have thirty (30) days (the "Cure Period") in which to cure
such breach or cause the breach to be cured. If the breach is not cured, or
waived by the non-breaching party, within the Cure Period, then the non-
breaching party shall be entitled to pursue any remedies it may have by reason
of such breach. The non-breaching party's remedy with respect to any breach
which is not cured or waived within the Cure Period shall include, without
limitation, terminating this Agreement with cause or commencing legal action
against the other party for damages related to such breach. Failure to terminate
this Agreement shall not serve to waive any breach hereof. If either party
commences legal action alleging any breach of this Agreement, the non-prevailing
party shall pay all costs and reasonable attorneys' fees incurred by the
prevailing party in connection therewith.

          (d)  This Agreement shall automatically renew for successive
additional twelve (12) month terms, unless Customer notifies CIS of its
intention not to renew at least one hundred

                                       14
<PAGE>

and eighty (180) days prior to the expiration of the Initial Term or any renewal
term or unless CIS notifies Customer of its intention not to renew at least
twelve (12) months prior to the expiration of the Initial Term or any renewal
term. Such renewals shall be for the fees and prices then in effect for CIS's
services or such other amounts as the parties may negotiate, but in no event
less than the total fees charged by CIS to Customer during the preceding twelve
(12) months. If Customer elects not to continue receiving services, Customer
shall specify in writing within thirty (30) days thereafter, the period of time
Customer estimates will be necessary to complete the de-installation of the
Services and Systems (such period not to extend beyond eighteen (18) months
after the expiration of the Initial Term or the then current term). For purposes
of this Section 11, the period commencing after the expiration of the Initial
Term or any renewal term and ending on the date determined above shall be the
"Wind-Down Period." If Customer fails to specify the Wind-Down Period as
provided herein, the Wind-Down Period shall be eighteen (18) months, unless
otherwise agreed.

          (e)  During the Wind-Down Period, the parties will establish and
implement a mutually acceptable de-installation plan, having due regard for the
cost and quantity of Services provided by CIS during the Wind-Down Period.
During the Wind-Down Period, the remaining provisions of this Agreement shall
continue in effect, except as follows:

                    (i)   CIS shall not be required to offer any Services or
               Systems to Customer beyond those already purchased by Customer at
               expiration of the Initial Term or any renewal term;

                    (ii)  During any remaining portion of the Initial Term or
               any renewal term, fees shall be charged as stated in this
               Agreement, thereafter, all fees and other charges shall be
               increased automatically by 25%; and

                    (iii) During the Wind-Down Period specified by Customer,
               Customer shall also pay the greater of its actual monthly fees
               incurred or a Minimum Monthly Processing Fees equal to one-
               twelfth of seventy-five percent (75%) of the prior year's total
               fees.

          (f)  In the event that this Agreement is terminated by Customer
without cause before the end of the Initial Term, Customer shall pay to CIS a
Termination Fee equal to the first month's total bill under the terms of this
Agreement, multiplied by the number of months remaining in the Initial Term.

          (g)  Following termination of this Agreement and upon CIS's request,
Customer shall deliver to CIS all Software and related documentation (including
copies thereof) or, at CIS's option, shall deliver to CIS a sworn statement
certifying that all Software and related documentation have been destroyed.

                                       15
<PAGE>

12.  Miscellaneous
     -------------

          (a)  Assignment.  Except as set forth herein, neither this Agreement,
               ----------
nor any of the rights, licenses or duties set forth herein, may be assigned by
Customer without the prior written consent of CIS.  This Agreement shall be
binding upon, inure to the benefit of, and be enforceable by the parties hereto
and their respective successors and permitted assigns.

          (b)  Access to Books and Records.  Upon written request of the
               ---------------------------
Secretary of Health and Human Services or the Comptroller General or any of
their duly authorized representatives, CIS shall make available to the
requesting party those contracts, books, documents and records necessary to
verify the nature and extent of the cost of providing its services.  CIS shall
cause such materials to be available for inspection for at least four (4) years
after the rendering of such Services and Systems.  If CIS carries out any of the
duties of this Agreement with a value of $10,000 or more over a twelve (12)
month period through a subcontract with a related individual organization, CIS
shall include this requirement in all such subcontracts.  The parties agree that
any attorney-client, accountant/client or any other legal privilege shall not be
deemed waived by virtue of the provisions of this Section 12.

          (c)  Taxes. The prices and amounts specified to be payable by Customer
               -----
hereunder do not, unless otherwise noted, include any sales, use, excise, value
added, utility or other similar tax or charge which may be or hereafter become
applicable to the Services and Systems provided hereunder.  Consequently, in
addition to such prices and amounts, the amount of any such taxes or charges
which may be or hereafter become applicable shall also be payable by Customer to
CIS, except that Customer shall have no responsibility for payment of taxes on
CIS's income or for payment of franchise taxes related to authorization of CIS
to conduct business in any state.  In lieu of paying any such taxes that may
otherwise be due, Customer may provide CIS with a tax exemption certificate
acceptable to the taxing authorities.  Customer shall be given prompt written
notice of any tax assessment against CIS for which Customer is liable hereunder,
and Customer shall have the right, at its own expense, to contest any such
assessment prior to its payment by CIS.  In the event Customer exercises such
right, it shall indemnify and hold harmless CIS from liability for all interest
and penalties relating to such contest.  Customer shall control any such contest
and CIS shall provide information and assistance in connection with such contest
to the extent reasonably requested by and at the expense of Customer.

          (d)  Divestiture of Facility. In the event that, during the term of
               -----------------------
this Agreement, Customer divests any Facility receiving any Systems or Services
hereunder, then in such event, such Facility's rights and obligations under this
Agreement may be assigned to the purchaser of such Facility, provided that:

               (1)  The purchaser assumes in writing the obligations of Customer
          hereunder with respect to such Facility; and

               (2)  No such assignment shall relieve Customer of its obligations
          hereunder in respect of such Facility.

     (3)  In lieu of assigning this Agreement, CIS, Customer and the purchaser
may agree that CIS and the purchaser shall execute a new agreement for the
provision of

                                       16
<PAGE>

Services and Systems, at which time this Agreement shall terminate in respect to
such Divested Facility.

               (4)  Any legal or other expenses reasonably incurred by CIS in
connection with actions taken in relation to Customer's divestiture of a
Facility shall be paid by Customer.

          (e)  Hiring.  During the term of this Agreement neither party shall
               ------
recruit, hire, offer employment to or refer for employment any of the agents or
employees of the other party, without such party's prior written permission.

          (f)  Disputes.  In the event that a dispute arises between CIS and
               --------
Customer which cannot be resolved in the normal course, the following dispute
resolution procedure shall be followed: (i) within ten (10) business days of a
written request by either party, that Facility's chief information officer (or
equivalent) and CIS' Director of Information Services shall meet and resolve the
issue; if these parties cannot resolve the issue within ten (10) business days
of the meeting, then (ii) the issue shall be submitted to Customer's CFO or
designee and CIS' Vice President for Client Services; if these parties cannot
resolve the issue within fifteen (15) business days of submission to them, then
(iii) the issue shall be submitted to Customer's CEO and CIS's President for
resolution.  If, after fifteen (15) business days, Customer's CEO and CIS's
President cannot resolve the matter, the parties may seek whatever other
remedies are available.

          (g)  Governing Law. This Agreement shall be governed by, and construed
               -------------
in accordance with, the laws of the State of Tennessee without regard to its
conflict of laws provisions. Any dispute hereunder shall be resolved in the
state or federal courts having jurisdiction located in Nashville, Tennessee. CIS
and Customer each hereby expressly submits and consents in advance the
jurisdiction of the United States District Court for the Middle District of
Tennessee and each hereby waives any objection which it may have based upon lack
of personal jurisdiction, improper venue or forum non conveniens.

     13.  Notices.  All notices or other communications required or permitted
          -------
under this Agreement shall be in writing and sufficient if sent by nationally
recognized overnight courier (for next business day delivery), facsimile
transfer device or certified mail, return receipt requested, to CIS or Customer
at the following addresses:

                         Columbia Information Systems, Inc.
                         2555 Park Plaza
                         P. O. Box 270
                         Nashville, Tennessee 37202
                         Facsimile: (615) 344-6777
                         ATTN: Data Center Contract Administrator

                                       17
<PAGE>

                         and


                         LifePoint Hospitals, Inc.
                         4525 Harding Road
                         Nashville, TN 37205
                         Facsimile: (615) 344-6276
                         ATTN:  Mr. Scott L. Mercy
                                Chairman and Chief Executive Officer

Any party may change the person and address to which notices or other
communications are to be sent to it by giving written notice of any such change
in the manner provided herein.

     14.  Entire Agreement; Amendment.  This Agreement, together with the
          ---------------------------
exhibits hereto, sets forth the entire agreement and understanding of the
parties hereto in respect of the transactions contemplated hereby, and
supersedes all prior agreements, arrangements and understandings relating to the
subject matter hereof.  No party hereto has relied upon any oral or written
statement, representation, warranty, covenant, condition, understanding or
agreement made by any other party or any representative, agent or employee
thereof, except for those expressly set forth in this Agreement or in the
exhibits or other documents delivered pursuant hereto.  This Agreement may be
amended, modified, superseded or supplemented only by an instrument in writing
executed and delivered by CIS and Customer.

     15.  Headings.  The section headings contained in this Agreement are
          --------
inserted for convenience of reference only and shall not affect the meaning or
interpretation of this Agreement.

     16.  Rights Cumulative; Waiver.  All rights and remedies conferred under
          -------------------------
this Agreement or by any other instrument or law shall be cumulative and may be
exercised singularly or concurrently.  The failure by either party to enforce
any term shall not be deemed to be a waiver of future enforcement of that or any
other term of this Agreement.

     17.  Counterparts.  This Agreement may be executed in any number of
          ------------
separate counterparts, each of which shall be deemed to constitute an original,
but which together shall constitute one and the same instrument.

     18.  Severability.  In the event that any provision hereof is prohibited or
          ------------
unenforceable in any jurisdiction, such provision shall, as to such
jurisdiction, be ineffective to the extent of such prohibition or
unenforceability without invalidating the remaining provisions hereof or
affecting the validity or unenforceability of such provision in any other
jurisdiction.

                                       18
<PAGE>

     IN WITNESS WHEREOF, the parties have caused this Computer and Data
Processing Transition Services Agreement to be executed by their duly authorized
representatives as of the day and date first referenced above.


COLUMBIA INFORMATION SYSTEMS, INC.

By: /s/ Noel Williams
   ------------------

Name:   Noel Williams

Title:  President

LIFEPOINT HOSPITALS, INC.


By: /s/ Kenneth C. Donahey
   -----------------------

Name:   Kenneth C. Donahey


Title:  Senior Vice President & CFO

                                       19