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NIOSH HomeNIOSH Pocket Guide to Chemical Hazards

NIOSH Pocket Guide to Chemical Hazards

• Introduction

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• CAS Numbers

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• Appendices

◦ A - NIOSH Potential Occupational Carcinogens

◦ B - Thirteen OSHA-Regulated Carcinogens

◦ C - Supplementary Exposure Limits

CDC - NIOSH Pocket Guide to Chemical Hazards - Toluene-2,4-diisocyanate Page 1 of 6

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◦ D - Substances with No Established RELs

◦ E - OSHA Respirator Requirements for Selected Chemicals

◦ F - Miscellaneous Notes

◦ G - 1989 Air Contaminants Update Project: Exposure Limits NOT in Effect

◦ Type C & CE - Definitions for Type C and Type CE Respirators

◦ Personal Protection and Sanitation Codes

◦ First Aid Procedures

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Toluene-2,4-diisocyanate 

Synonyms & Trade Names

TDI; 2,4-TDI; 2,4-Toluene diisocyanate 

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CDC - NIOSH Pocket Guide to Chemical Hazards - Toluene-2,4-diisocyanate Page 2 of 6

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CAS No.

584-84-9 

RTECS No.

CZ6300000

DOT ID & Guide

2078 156

External Web Site Icon

Formula

CH3C6H3(NCO)2

Conversion

1 ppm = 7.13 mg/m3

IDLH

Ca [2.5 ppm]

See: 584849

Exposure Limits

NIOSH REL

: Ca See Appendix A

OSHA PEL

†: C 0.02 ppm (0.14 mg/m3) 

Measurement Methods

NIOSH 2535 

Adobe PDF file

 , 5521 

Adobe PDF file

 , 

5522 

Adobe PDF file

 , 5525 

Adobe PDF file

;

OSHA 18

External Web Site Icon

 , 33

External Web Site Icon

 , 42

External Web Site Icon

See: NMAM or OSHA Methods

External Web Site Icon

Physical Description

Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. 

MW:

174.2 

BP:

484°F

MLT: 71°

F

Sol:

Insoluble

VP(77°F): 0.01 mmHg IP:

?

Sp.Gr:

1.22

Fl.P:

260°F

UEL:

9.5%

LEL:

0.9%

Class IIIB Combustible Liquid: Fl.P. at or above 200°F.

Incompatibilities & Reactivities

Strong oxidizers, water, acids, bases & amines (may cause foam & spatter); alcohols [Note: Reacts slowly with water to 

form carbon dioxide and polyureas.]

Exposure Routes

inhalation, ingestion, skin and/or eye contact 

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Symptoms

irritation eyes, skin, nose, throat; choke, paroxysmal cough; chest pain, retrosternal (occurring behind the sternum) 

soreness; nausea, vomiting, abdominal pain; bronchitis, bronchospasm, pulmonary edema; dyspnea (breathing difficulty), 

asthma; conjunctivitis, lacrimation (discharge of tears); dermatitis, skin sensitization; [potential occupational carcinogen] 

Target Organs

Eyes, skin, respiratory system 

Cancer Site

[in animals: pancreas, liver, mammary gland, circulatory sys & skin tumors]

Personal Protection/Sanitation

(See protection codes) 

Skin: Prevent skin contact 

Eyes: Prevent eye contact 

Wash skin: When contaminated/Daily 

Remove: When wet or contaminated 

Change: Daily 

Provide: Eyewash, Quick drench

First Aid

(See procedures)

Eye: Irrigate immediately 

Skin: Soap wash immediately 

Breathing: Respiratory support 

Swallow: Medical attention immediately

Respirator Recommendations

NIOSH

At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration:

(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or 

other positive-pressure mode

(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positivepressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus 

Escape:

(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor 

canister

Any appropriate escape-type, self-contained breathing apparatus 

Important additional information about respirator selection

See also: INTRODUCTION See ICSC CARD: 0339 See MEDICAL TESTS: 0233

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• Page last reviewed: April 4, 2011

• Page last updated: November 18, 2010

• Content source: National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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