UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 

### MAR 112015

MEMORANDUM
SUBJECT: BEAD Chemical Profile for Re FROM: Colwell Cook, Entomologist Biological Analysis Branch

THRU:

TO: Cynthia Doucoure, Environmental Protection Specialist Science Information and Analysis Branch Elizabeth Hill, Economist Economic Analysis Branch Biological and Economic Analysis Division (7503P) Arnet Jones, Chief Biological Analysis Branch Diann Sims, Chief

# ~ Science Information and Analysis Branch Timothy Kiely, Chief

# ~\IV\

# l/A Economic Analysis Branch

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# LJ Biological and Economic Analysis ivision (7503P) Kelly Ballard, Chemical ReviewManager Risk Management and Implementation Branch I Pesticide Re-evaluation Division (7508P)
Product Review Panel date: February 26, 2015



### 1 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION

### SUMMARY Rotenone is a botanical pesticide first registered inthe U.S. in 1947. Only piscicidal uses are currently registered inthe U.S., as all other uses were voluntarily canceled during the Reregistrationprocess in 2006. Itis applied to lakes, ponds, reservoirs, rivers, and streams typically to kill invasive or non-native fish for habitat restoration purposes. The mode ofaction is blocking electrontransport at complex I, thus uncoupling oxidative phosphorylationwithinthe mitochondria. BEAD has data from other government agencies indicating small amounts ofuse. 

### INTRODUCTION The purpose ofthis do
. cument is to convey usage information and a broad overview ofthepest managementroles·ofrotenonethat is beginning to undergo registration review. The anticipated audience consists ofthe team ofEPA staffcurrently evaluating the registration status of rotenone, and eventually the general public. This document is based on information and data available to BEAD as ofFebruary 2015.


### HISTORY OFBEAD ASSESSMENTS FORROTENONE BEAD conducted an alternatives analysis for antimycin A and rotenone in lakes and streams in 2006 (Kaul and Faulkner, 2006). Their finding thatthese are the only piscicides in the U.S. remains true today.


### REGISTRATIONS Currently there are 12 Section 3, 2 Section 24(c), and 2 pending registrations for rotenone. There is also an Experimental Use Permit.


### COMMON FORMULATIONS AND APPLICATION METHODS Rotenone is formulated as a dust, liquid, emulsifiable concentrate, and wettable powder. Dust formulations must be mixed as a slurry to be applied to water surface by dragging equipment to release product behind a boatbelowthe water surface. Applications can be made with aircraft, backpack sprayer, drip can, orhandheld orhand-directed nozzle to the water surface.


### CURRENT USE SITES Rotenone is registered for use in aquatic areas, including lakes, ponds, reservoirs, rivers, streams and in aquaculture. 2BIOLOGICAL ASPECTS RELEVANT TO ROTENONE Rotenorte is a Restricted Use Pesticide used in aquatic situations to manage fish. It is related to isoflavonoid compounds derived from the roots ofDerris spp., Lonchocarpus spp., and Tephrosia spp. Ittargets undesired fish species in lakes, ponds, reservoirs, rivers, streams, and iri aquaculture. Its mode ofaction is through uncoupling oxidative phosphorylation within cell mitochondriaby blocking the electron transport at complex I.
ROLE OF ROTENONE IN PEST MANAGEMENT Itis one oftwo piscicides registered inthe U.S. Itis critical for managing invasive fish species as well as for eliminating non-native fish in habitat restoration.
INFORMATION THAT MAY BE USEFUL FORBEAD'S FUTURE WORK ON ROTENONE The Agency has limited informationthat some government agencies use small amounts rotenone. Obtaining more usage information may improve future assessments conducted by the Agency related to the use and importance of**~otenone:** • Aquatic areas: usage data (pounds a.i. applied peryear, maximum rate ofapplication, number ofapplications peryear).
REFERENCES Kaul, M., 

### J. Faulkner. 2006. Memorandum to Lance Wormell: Alternatives Analysis for Antimycin A and Rotenone in Lakes and Streams (DP# 310753 and 307400).

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