|   | FIRST: | That      at a meeting of the Board of Directors of the Corporation, resolutions      were duly adopted setting forth a proposed amendment of the Corporation’s      Restated Certificate of Incorporation, declaring such amendment to be      advisable and calling a meeting of the Corporation’s stockholders for      consideration thereof.  The resolution setting forth the      proposed amendment is as follows: |
|--------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                             |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                             | RESOLVED      that, subject to stockholder approval, the Corporation’s restated      certificate of incorporation be amended by changing Article I thereof so      that, as amended, such Article shall be and read as    follows: |
|   |   |                                                                                                                                                                                                                                                                                                                                                                                                                                             |   |

|   | SECOND: | That      thereafter, pursuant to a resolution of its Board of Directors, the      regular meeting of the Corporation’s stockholders was duly called and held      upon notice in accordance with the provisions of Section 222 of the DGCL,      at which meeting the necessary number of shares as required by applicable      law were voted in favor of such amendment. |
|--------|---------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   |    |                                                                                                                                                                                                                                                                                                                                                                              |
|   | THIRD:  | That      such amendment was duly adopted in accordance with the provisions of      Section 242 of the DGCL.                                                                                                                                                                                                                                                                      |

|        LEXICON      GENETICS INCORPORATED |
|------------------------------------------------|
|                                           |   |
|                                           |   |
| By:                                            | /s/      Jeffrey L. Wade |
|                                           | Executive      Vice President and General Counsel |