### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460



## MEMORANDUM Date: 29 March 20 16 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION



## SUBJECT: Fluen s ulfonc . Ac ute and C hronic Aggregate Dietar y (Foo d and Drinking Wate r) Exposure and Risk Assessments for the New Use Sect ion 3 R eg istratio n Action on Root Vegetab le s (Except Sugar B eet) , Tuberous and Corm Vegetables , Leafy Vegetables (Except 

## Brassica Vegetables) , 

## Brassica (Co le) Leafy Vegetables, Fruiting and C uc urbit Ve getables , and Low growing be rry Crop Groups / Subgroups. 

## PC Code : 050410 DP 

## Barcode: D4 32134 

## Deci s ion No.: 50 

## I793 

## R egistration No.: 66222-243, 66222 -E AE 

## Petition No.: 5 F8 35 

### l 

## Re gulatory Action : Section 3 Registration 

## Ri sk Asses s ment T y pe: Dietary 

## Case No .: None 

## TXR No.: NA 

## CAS No .: 318290-98-1 

### MRID 

## No.: NA 

### 40 

## CFR: §18 0. 680 

## FROM: Janet V . Cowins , Ph.D ., Chemist{)./.- 

# V:

# ~ Ri sk Assessment Branch If / 

### Health Effects Division (HED , 7509P)**~** 

## THROUGH: Denni s McNe ill ey, Chemist

# c;;;~**lf1** C--

# ~ ldeliz Negr6n-Encamac i6n, Ph.D., Chemist c..------::

### Di**etary~~posu re**  Science Advisory Coun cil

### D.~ A5) 

# ,I**~** 

# . ;} 

# j Michael A. 

### Doherty , Ph.D ., Senior Chem ist

# ~**~** Risk Assessment Branch Tl Health Effects Division (7509P) 

## TO: Rita Kumar/Mari a nne Lewis/ Meredith Law s f nvertebrate and Vertebrate Branch 3 R egistration Di vision (7505P) Andrew Ertma n/Barba ra Madden/Mar ion J o hn so n Ri sk In te gration , Minor Use, and Emergency R espo nse B ranch R egis tratio n Di vision (75 05P) Page I of 19

### Fluensulfone Dietary Exposure and Ri sk Assessment DP Number: D432 I 34 

### Executive Summary Acute and chronic aggregate dietary (food and drinking water) exposure and ri s k assessments were conducted using the D ie tary Exposure Eval uation Model software with the Food Commodity Intake Database (DEEM-FCID ) Version 3.16. This software u ses 2003-2008 food consumpt ion data from the U.S. Department of Agri culture 's (USDA's) National Health and Nutr iti on Exam ination Survey , What We Eat in America , (NHANES/WWE l A). The analyses were conducted in support of a human-health risk assessment for the propos e d Section 3 registration of tluensulfone on root vegetables (except sugar beet). tuberous and corm vegetables , leafy vegetables (excep t 

### brassica vegetables). 

### brassica (co t e) leafy vegetables , and low growing berry crop group/ subgroup 1 

### B , l C , 4, 5 , and I 3 -07G , respectively. In addition to this, a label amendment was submitted to increase the applicat ion rate of fruiting vegetables (group 8-10) and c ucurbit vegetab le s (group 9). Therefore , the crops from the previous assessment will also be included. Field trial data from root and leafy vegetables exhibited the highest re s idues of fluensulfon e in carrot (0.9 ppm) , celery ( 1.0 ppm) , head lettuc e (0. 1 ppm) and leaf lettuce (0.03 ppm). Acute and chronic dietary exposure analyses were based on high-end est im ates of fluensulfon e re sidues , l 00% crop treated , and high-end estimates of residues in drinking water. Acute ri sk estimates , as a percentage of the acute population-adjusted dose (aPAD) , range from 2.4% for you th 13-19 years of age to 9 .3% for all infants , at the 95 111 

### percentile of exposure. T he acute dietary ri s k estimate for the general U.S. population is 3.0% aPAD. Chronic ri sk estimates ran ge from 0. 9% of the chronic population-adju sted dose (cPAD) for youths 13-19 years of age to 3 . 9% for all infants. T he chronic dietary ri s k estimate for the general U.S. population is 1.3% cPAD. Ri sk estima te s based on scr eeni n g-leve l assumptions and tolerance-level residues are below HED ' s level of concern for both exposure duration s and for all population subgroups. For all est imates , the majority of the exposure i s due to residues in drinking water. 

### I. Introductio n 

### Dietary ri s k assessment incorporates both exposure and tox ic ity of a g i ven pesticide . For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e. , the dose that H ED has concluded will result in no unrea sonable advers e health effects). This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the point of departure (POD , NOAEL, LOA EL, e.g.) divided by the required uncertainty or safety factors. For acute and non - cancer chronic exposures , HED is concerned when estimated dietary risk exceeds 100% of the P AD. References that discuss the acute and chronic ri sk assessments in more detail are available on the EPA/pe s ticid es web site: "Available Information on Assessing Exposure from Pesticide s, A User's Guide;· 2 l-JUN

- 2000. web link: http: //www.regulations.gov/# !documentD etail:D =E PA-HQ-OPP-2007-0780-0001 ; or see SOP 99.6 (20-AUG-1999). The mo st recent dietary ri s k assessment for Flue nsulfone was conducted b y Michael A. 

### Doh erty 

### (I 0 June 2014; 0418204 ). Page 2of 19

### Fluensulfone Dietary Exposure and Ri sk Assessment DP Number: 0432134



### II. Residue Information Tolerances have been esta bli s hed for fluensulfone (40CFR 

### § 180.680) on fruiting and cucurbit vegetables, as well as tomato paste. Accompanied by this tolerance es tabli s hm ent , is a l so a Sect io n 18 registrati on on carrot. These analyses were performed to suppo rt the esta blishment of a tolerance for fluen s ulfone residues inion the aforementioned crops. Fluensulfo ne is used to treat various agricultural crops , commercial turf and sod farms. Following application, fluensulfone breaks down to form, primaril y, BSA (3,4 ,4-trifluoro-but-3-ene -1-sulfonic acid ) and TSA (5 -chloro-thiazol e - 2-sulfonic acid) to such an extent that quantifiable residues of parent fluen s ulfone are typically not expected in harvested commodities. However , in root (carro t) and leafy vegetables (except Brassica vegetables) (celery , head , and leaf lettuc e), quantifiable resid ues offluensulfon e were present. The residu e definitions for fluensulfon e a r e summarized in Table I. 

### Becau se of th e res idue profile , to lerances for fluensulfone are based on analysis of BSA o nl y; however , BSA is co n s id ered to be of very low toxicity and risk estimates are based on residues of the parent compound in foods and on combi ned residues of fluensulfone , deschlorofluensulfone , and the methyl sulfone metabolite ( MeS) in drinking water (0412114; E. H olman ; 27 August 2013). For both the acute and chronic assess ments , high end estimates are assumed for all crops . Residues in drinking water are discu ssed in Section IV , below. Parent tluensulfone occ urs at residue le vel s well be low those of BSA , the r es idue defined for th e enfo rcement of tolerances. S in ce tolerances do not include fluensulfone itse lf, HED has used the OECD 

## MRL calculation procedures to derive to le rance-equivalent residue leve l s for fluensulfone. For foods where the leve l of fluensulfone is expec ted to be below the limit of quantification (LOQ). 0.0 I 

### ppm , HED has assumed that residues occur at the LOQ. For foods w ith quantifiable le ve l s of tluensulfone. HED ha s assumed that residues occ ur at the toleranceequivalent level. In addit ion to the new use s reque s ted for fluensulfone , the dietary assessment also addresses the label amendments affecting the previously registered uses for the compound. Translation of field trial data from repre sentative com modities were used in this assessment following the dietary expos ure guidance; see HED SOP 2000 . 1 (12 September 2000). For the r e maining crops where fluensulfone was less than the LOQ , a screeni ng- leve l analys i s was performed based on flu e ns ulfone residues at the limit of quantitation (0.0 l ppm). The drinkin g water estimates for the acute and chronic analy s is is provided in Table 3 and discussed in Section l Y below. An input re s idue table for selected flu e ns ulfone commoditie s i s provided in Table 2. A complet e listing of the res idues used in the acute and chronic analyse s are included in A nachment 1 .

Tab le 1. 

### Summary of Metabo li tes and Degrada tes to be included in the Risk Asses s ment and Toleranc e Expres sion Matri x Resid ue s includ ed in Ri s k Res idu es in c lud ed in T olerance Assessment Ex press io n Pl ants Primary Crop 

### Fluen sulfone 

### BSA. Rotational Cro p 

### Fluensulfon e 

### BSA. Live stock Rumin ant None None Poul try None None

Page 3of 19Fluen s ulfone D ietary Exposure and Ri s k Assessment DP Number: D432 l 34 Tab l e 1. S umm ary o f Metabolites and Degradates to be included in th e Ri s k Asse ss m ent a nd To l e ranc e E xpression Matri x Re s idue s includ ed in Ri s k R es idu es inc luded in To le r a n ce A ssess ment Ex pr ess io n Flu ens ulfon e + Mes· + deschloro

- Not App licable Drinking Water fluensulfone , expressed as parent equivalen t

Tab le2. Input Tab le Fo r F lu ens ulf one Commo diti es . Co mmodity Name Crop Group / S u bgroup Antic ip ated Re s idu e Es timatesrro le ran ce Beet, garden , roo t s IA/ IB 0.01 Beet, garden , ro ots-babv food Burdock IA/I B 0.01 Carro t Carrot-baby food IA/I B 0.90 Carrot, ju ic e Ce leriac IA/IB 0.0 1 Chicory , roots I A / I B 0.90 Ginseng, dri ed IA/ IB 0.90 Horseradish IA/I B 0.90 Pars ley, turnip rooted IA/ IB 0.90 Parsnip I NIB 0.90 Parsn ip-babyfood Radish , roots IA/ IB 0.01 Radish , Orient a l, root s IA/ I B 0.0 1 Rutabaga I A/ IB 0.01 Sa ls ify , roots IA/I B 0.90 Turnip , roots IA/18 0.01 Arrowroot, flour IC/ ID 0.01 Arrowroot, flour-babyfo od Artichoke, J erusa lem IC/I D 0.01 Cassava 0.01 Cassava- bab y food IC/ ID Das heen , corm IC/ID 0.0 1 Ginger G inger-babyfood IC/ ID 0.01 Ginger, dried

Page 4of19

### Fluensulfone Dietary Exposure and Ri sk Assessment DP Number: D432 J 

### 34 

### Tab le2. Input Tab l e Fo r Fluensu lfone Co mmoditi es . Co mmodity Name Crop Group/ Subg roup Anticipated Resi due Es tim atesffo lerance Potato , ch ip s Potato, dry (granu l estnakes) Potato, dry (granul estnak es)

- babyfood Potato , flour IC 0.01 Potato, llour

-babyfood Potato, tuber, w /pe el Potato-tuber, w /peel-babyfood Potato, ruber, w/o pe e l Potato , tuber, w /o peelbabvfood Sweet potato IC / ID 0.0 1 Sweet**eotato -b** **ab~food** 

### Tanier, corm I 

### IC/ ID 0.0 1 Tu meric IC/ ID 0.0 1 Yam, true Yam bean IC/ I D 0.01 Beet, ga rd e n, tops 2 0.01 Chicory, top s 2 0.01 Dashee n , leaves 2 0 .0 1 Radis h , to ps 2 0.0 1 Radish , Oriental , top s 2 0.0 1 Sals i fy, top s 2 0.01 Amaranth , leafy 4A 0.0 1 Arugula 4A 

### I 0.01 Chysantheum , garland 4A 0.01 Cress , garden 4A 0.0 1 Cress, upland 4A 0.01 Dande lion , leaves 4A 0 .01 Endive 4A 0 .0 1 L

e ttuce , head 4A 0.03 L

ett uce , leaf 4A 0. 10 P

arse ly , leaves 4A 0.01 Radicchio 4A 0.03 Spinach 4A 0.01 Sp inach-bab vfood Cardoon 48 0.0 1 Ce lery Ce lery-baby food 4 8 1.0 Ce l e 1

)'., ju ice 

## - Ce ltu ce 48 1. 0 Fennel, Florence 48 1.0 Rhubarb I 

### 4 8 1.0 Swiss chard 48 1.0 Broccoli Broccol i-babyfood SA 0.01 Broccoli, Chinese

P age 5of 19Fluensulfone Dietary Exposure and Risk Assessment DP Number: D432134 Tab le2 . Input Table Fo r F lu e nsulfooe Commoditi es. Commodity Name C rop Group /S ubgroup Ant i c ipated Residue Estimatestrol erance Bru sse ls sprouts 

### SA 0.01 Cabbage Cabbage, Chinese, napa SA 0.01 Cabbage, Chinese , mu s tard Cauliflower 5A 0.01 Kohlrabi 5A 0.01 Broccoli raab 5B 

### I 0.01 Cabbage, Chinese , bok choy 

### I 58 0.0 1 Colla rd s SB 0.0 1 Kale SB 0.01 Mustard greens 5B 0.01 Rape gree ns 50 0.01 T urnip , g reen s SB 0.01 Tomatillo 8A 0.01 Tomato Tomato-babyfood Tomato, paste Tomato , paste-babyfood Tomato, puree 

### 8A 0.01 Tomato, puree-babyfo od Tomato , dried Tomato , dried-babyfood Tomato , juice Tomato. Tree E!.?.!.?.o lant 8B/ 8C 0.01 

### Okra 8B/ 8C 0.01 Pepper , bell Pepper, bell-babyfood 88 0.01 Pepper, bell, dried Pepper, bell, dried-babvfood Pepper, nonbell Pepper, nonbell-bab yfood 8B /8C 0.01 P

eooer, nonbell, dried Canta louee 9A 0.01 Honeydew melon 9A 0.01 Watennelon 9A 0.01 Watennelon. juice Balsam pear 9B 0.01 C hayo te , fruit 9B 0.01 Chinese waxgourd 9B 

### I 0.01 C ucumber 9B 0.01 Pumpkin 9B 0.01 Pumpkin , seed Squash, summer 98 0 .01 Squash, summer-babvfood Squash, winter 98 0.01 Squash, winter-bab yfoo d I

Page 6 of 19

### Fluensulfone Dietary Exposure and Ri sk Assess ment DP Number: D432134 

### Ta bl e2 . Input Tab le Fo r Fluen sulf on e Commod iti es. Com m od i ty Name Crop Group/Subgrou p Anti c ipate d Res idue Es tim a tesff ol eran ce Cranberry Cranberry-baby food Cranberry, dried 13G 0.01 Cranberry , juice Cranberry , iuice-babyfood Strawberry Strawberry

-bab yfoo d 13G 0.01 Strawberry, juice S t

rawberry , jui ce-babyfood Water , dir ec t, all so urce s N IA 

### Ac ute = 0.0776 p pm Water , ind i rec t, a ll so urces Chroni c = 0.0525 ppm

Page 7of 1 9

## Ill. Percent Crop Trea ted In formation Percent crop treated information was not used in e ithe r the acute or chronic analys i s (i .e . 1 00% crop treated assumed). 

### IV. 

## Drinkin g Water Data Estimates of tluensulfone residues of concern in drinking water were provided by the Env ironmental Fate and E ffects Division (EFED) in a memo titled " Fluensulfone: Drinking Water Exposure Assessment for Proposed New Uses on Turfgrass " 

### (J. Lin, 0424167 , 19 February 2015). The me morandum notes that the estimated drinking water co nc entratio ns (EOWCs) based on the use on 

## turf are less than tho se derived from the u se on cucurbit vegetables and fruiting vegetables. As the use patterns for the new crops are essenti ally identical to that for cucurbit and fruiting vegetables , HED has used the cucurbit/fruiti ng vegetable based EDWCs provided by EFE O 

### (J. Lin , 0411774. I August 2013 and 

### J. Lin, 0417634, 30 January 2013 ). The drinking water residues used in the dietary risk assessment remain unchanged and can be found in the previous dietary risk assessme nt ( 0418204; M. Dohert y : 10 June 2014). The estimated drinking water concentrations (EOWCs; Table 3) were incorporated directly into this dietary assessment via the food categories "wat e r, direct , a ll sources" and · ' water , indirect , all so urc es." As previously noted , the residues of concern in drinking water are fluen s ulfone , deschlorofluensulfone , and MeS. Oeschloro

- fluensulfone was only observed in e n vironmenta l fate studies applicable to surface water residues and was not included in groundwater. The surface water est imates were obtained u s in g a total

-residu e approach with Pesticide Root Zone Model and Exposure Analysis Model System (PRZM-EXAMS). The groundwater (EOWCs) were obtained using the Pesticide Root Zo ne Model-Ground Water (PRZM -G W) in a combined approach whereby res idue es timates for :fluensulfone and MeS were obtained from separate analyses and then added to gethe r, r es ultin g in conservative estimates of the combined residues . The drinking water models and th ei r descriptions are availab l e at the EPA internet s ite: Mode ls for Pesticide Risk Assessment.

Table 3. F lu ensulfone Est im ated Drinkin g Water Co nc ent r atio ns f o r Dietary R isk Assess ment ID411 77 4 +D 41 763 4) Re si due Source (Tier: Model) Use Rate , lb a. i./ A

/ yr Acute EDWC, μ g/L Chronic EDWC , μg/ L Surface Water (Tier II: PRZM-EXAMS 

### 3.57 

### 11.8 0.173 G roundwater (Tier I: PRZM-GW) 

### 3.57 

### 77 . 6 52.S 

### The maximum values for acute and chronic EDWCs are from the groundwater modeling and were used in the dietary exposure assessment.

Page 8of19

### Fluensulfone Dierary Exposure and Ri sk Assessment DP Number: 0432134 

## V. DEEM -FC ID Progr am and Con sump t io

n Inform atio n Fluensulfone acute and chronic dietary exposure assessments were conducted using the DEEMFCID , Version 3.16, which incorporates 2003-2008 conswnption data from USOA's NHANES /WWEIA. The data are based on the reported consumption of more than 20,000 individual s over two non-consecutive survey days. Foods .. as co n sumed " (e.g. , apple pie) are linked to EPA-defined food commodities (e.g. , apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat fl o ur - cooked; fresh or N/ S, baked) usi ng publicly availab le recipe translat ion files developed jointly by USDA/A RS and EPA. For chronic exposure assessment , consumption data are averaged for the entire U.S . population and within population s ubgroups. However , for acute exposure assessment, consumption data are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA conswnption data, which took into account dietary pattern s and survey re spo ndents , H ED conc luded that it is most appropriate to report ris k for the following population subgroups: the general U.S. population , all infants (< 1 yea r old), children 1

- 2 , children 3-5, children 6-12, youth 13-19 , adults 20-49 , females 13-49 , and adults 50-99 years old. For a chronic dietary exposure assessment , an estimate of the residue leve l in each food or foodform (e.g. , orange or orange juice) on the food commodity r es i due list is multip lied by the average daily consumption estimate for that food/food form to produce a re s idue intake estimate. The resulting residue intake estimate for each food /food form is summed with the residue intake estimate s for all other food/ food forms o n the commodity r esidue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population s ubgroup. For an ac u te expos ure assessment , individua l one-day food consumption data are used on an individual-by-individual basis. The reported consum ption amounts of each food ite m can be multiplied by a residue point est imate and s ummed to obtain a total daily pesticide exposure for a determini s tic exposure asse ss ment , or ' ·matched" in multipl e random pairings w ith residue va lu es and then summed in a probabilistic assessment. The re s ulting distribution of expos ures is expressed as a percentag e of th e aPAD on both a user (i .e. , only those who reported eating relevant commodities/ food fo rm s) and a per-capita (i.e. , those who reported eati ng the relevant commodities as well as thos e who did not) ba s is. In accordance with HED policy , per capita exposure and ri sk are reported for analyses performed at all le ve ls of refinement. However, for deterministic assessments , any s ign ificant diff e rences in user vs. per capita exposure and risk are spec ifi cally identified and noted in the risk as sessment. V I. T o xico lo gica l Inform atio n For fluen s ulfone , HED has selected the most sensitive and protective endpoint s from the database to establ i sh points of departure (PODs) for the risk a ssess ment. The POD for acute dietary exposure was chosen from the 2 -gene ration reproductive toxicity study in rat s based on an increase in pup loss observed at 122 . 01169. l mg/kg/day (M/ F) with a NOAEL of 16.2/23 . 0 mg/kg/day (M/F). The POD for chronic dietary exposure wa s cho se n from the chronic study in rats , base d on a NOAEL of 9.6 mg/kg/d ay with decreased body weight in male s . hematology and clinical chemistry change s, histopathological effects in the lung and esophagus at the LOAEL of

Page 9of19

### Fluensulfone Dietary E xposure and Ri sk Assessment DP Number : D432 I 34 

### 57.7 m g/kg/da y . For bot h acute and chronic sce narios , th e inte r- and intra- s pec ies u ncertainty factors a re lOX each and the FQPA Safety Factor has been red uced to IX , res ulti ng 

### in an aPAD of0. 16 mg/kg/day and a c PAD of0 .10 mg/ kg/day . Fluen su lfone has been c la ss ifi ed as hav in g su ggest ive ev idence of ca rci noge nici ty, w ith a finding that the RID is protective of cancer effects. T ab le 4. S u mmary o f Toxico logica l Doses a nd Endp o in ts for u se in Flu e ns u lfone Di etary Human Hea lth Ri s k A ssess me n ts . E

xposure/ Scenario Point of Uncertain t y

/ RID. PAD , Study and Toxicologica l Effect s Departur e FQPA Safety Level of Factors Co nc ern for Ri sk A

ssess ment Acute Di e tary (A ll Off spring UF"= I Ox Acute RID = 2 -ge neratio n reproduction

- rat Population s, NOA EL= 16 .2 UFH = IO x 0.16 m g/kg/day Offspring LOA EL = 1 22 .0 mg/ kg/day inc ludin g In fants and mg/kg/day FQPA S F = Ix ba sed on an inc re ase in pup loss Children and aPAD = 0.16 bet ween PND I and 4 in the Fl and F2 Female s 13-49 years mg/kg/day offspri ng wi th the majo ri ty of deat hs of age) occ urring on day 2. Chronic Dietar y (A ll NOAEL = 9.6 UFA= IOx Chronic RID = 2-year toxicity/carcinogenici ty - rat Popul ati on s) mg/kg/day UF11 = 10x 0. 10 LOAEL = 57.7 mg/kg/day based on FQPA SF= I x mg/kg/day dec rease d body weight in ma les, hematology and c linical chemistry cPA D =0. 10 changes, histopathological effects in mg/kg/day the lung and eso phagu s. Cancer (ora l, de rmal , Classification: Sugges ti ve evidence of carcinogenicity in 

### human s based on benign lun g inhalation) tumors in female rats. The RID is protective of potential cancer effects. Point of Departure ( POD) = A data point or an es timat e d point that is deriv ed from ob served do se -response data and used to mark the beginnin g of ex trapo lation to determine ri sk associated with lower enviro nm entall y re l evant hum a n exposure s. NOAE L = no observed adver se effec t l eve l. LOAEL = lowest observe d adverse e ffect level. UF = uncertain ty factor. UF A= ex trapolation from animal to human (i nter spec ie s). UF11 = pote ntial variation in sensit ivi t y amon g members of the human population ( intras pecies). FQPA SF = FQPA Safety Factor. PAD = population adjus ted dose (a= acute, c = chronic). RID = reference dose. 

### For BSA and TSA , ora l acute lethality s tudi es were showed these metabolites to b e of low toxicity (Toxic it y Catego r y III ). HED notes that all animal s treat ed with BSA o r TSA surv ived the e ntire s tudy period and that the toxicity cat egory for tho se metabolites is based on the do s ing le vel rather than on actua l LD so es timates. In 28 -d ay oral toxicity studie s with BSA and T SA, no treatment-re late d e ffe c ts we r e observed at any dose ( limit-dose = 1000 mg/kg/day). VII. R es ults/ D i s cu ss ion As previou s ly s tated , fo r ac ute and chronic assess ments, HED i s concerned w he n dietary ri s k e stimates exceed 100% of the PAD. The D EEM-FCID anal yses es timate the dietary exposure o f the U.S. pop ul ation and vari o us p opul ati o n s ubgroups. The ri s k estimates for the total U .S. popul at io n and all popul ati o n s ubgroup s a r e be low HED 's leve l of concern fo r both ac ute and chro n ic exposure duration s (see Tab le 5).

P age 10of19Fluensu lfone Dietary Exposure and Ri s k Assessment DP Number: 0432134 Ta bl e 5 . S umma ry of Ac ute a n d Ch r o ni c D ieta r y Expos ure (Foo d a n d D r i n king W ate r ) a nd Ri s k Estim ates fo r F lu ens ul fone. Ac u te Dietary Ch r o n ic Dietary 

### (95'b Percent ile) Population S u bg r oup Di etary Exp os u re D ietary Ex p os ure {me/k2/day) %aPAD* ( me/kg/day) % cPAD * Genera l 

### U.S. Population 0 .004809 3 .0 0.001335 

### 1.3 A ll I nfa n t s (< I year o ld) 0.0 14794 9.3 0.00392 1 3.9 Children 1- 2 years old 0.008369 5.2 0.002283 2.3 Children 3

- 5 years old 0.0065 1 3 4.1 0.00 18 11 1.8 Children 6-12 ye ars old 0.004649 2.9 0.001234 1.2 Youth 13-19 years o ld 0.003774 2.4 0.000943 0.9 Adu lts 20-49 years old 0.004564 2.9 0.001279 

### 1.3 Adults 50-99 years old 0.004 165 2.6 0.00 1297 

### 1.3 Females 13-49 years old 0.004601 2.9 0.001276 1.3 Bo ld entrie s are maximum exposure and risk estimate s. 

### VIII. C h a r acte riz ation o flnpu ts/Ou tp u ts The res ult s in Tab le 5 reflect an unrefined , sc r ee ning-l evel assessment and like ly ove rest im ate actual dietary exposure to fluensu lfone. Various refinements co uld be made to the assessment s. However. as there are no ri sk estimates of concern , no refinements were incorporated. 

### IX . Con clu s io ns B ased o n the unrefined nature of the acute and chro nic dietary exposure assessments , H ED is confident that the estimates do not underestimate risk to the genera l U.S. population or any populat ion s ub g roup. The re are no dietary exposure or risk considerations that would preclude granting the requested registrations and associated tolerances for fluensulfone. 

### X. Li s t o f Attac hm en ts 1. Input s used in the acute dietary exposu re assessment for fluensulfone. 2. Inputs used in the c hronic dietary expos ure assessment fo r fluensulfone. 3. Summary of acute dietary exposure and risk estimate s for fluensulfone. 4. S ummary of c hro ni c dietary exposure a nd ri s k est im ates for fl uens ul fo ne.

Page 11 of 19

### Fluensulfone Di etary Exposure and Ri sk Assessment DP Number : D432 I 34 

### Attachment l: Inpu ts u sed in the acute d ieta ry expos ure asse ss ment for flu e n s ul fone . Filename : C : \Users\jcowins\Desktop\DEEM Files\Fluensulfone\Acute Fluensulfone-new . R08 Chemical : Fluensulfone RfD(Chronic) : . 1 mg/kg bw/day NOEL(Chronic) : 0 mg/kg bw/day RfD(Acute) : . 16 mg/kg bw/day NOEL(Acute) : 0 mg/kg bw/day Date created/last modified : 04

- 26-2016/15 : 22 : 09 Program ver . 3 . 16 , 03-08-d Crop EPA Code Grp Commodity Name Def Res (ppm) 0101050000 lAB 0101050001 !AB 0101067000 lAB 0101078000 lAB 0101078001 lAB 0101079000 lAB 0101084000 !AB 0101100000 !AB 0101168000 lAB 0101190000 lAB 0101250000 lAB 0101251000 lAB 0101251001 lAB 0101314000 lAB 0101316000 lAB 0101327000 lAB 0101331000 lAB 0101388000 lAB 0103015000 lCD 0103015001 lCD 0103017000 lCD 0103082000 lCD 0 1 03082001 !CD 0103139000 lCD 0103166000 lCD 0103166001 lCD 0103167000 lCD 0103296000 lC 0103297000 lC 0103297001 lC 0103298000 lC 0103298001 lC 0103299000 lC 0103299001 lC 0103300000 lC 0103300001 lC 0103366000 lCD 0103366001 lCD 0103371000 lCD 0103387000 lCD 0103406000 lCD 0103407000 lCD 0200051000 2 0200101000 2 0200140000 2 0200315000 2 0200317000 2 0200332000 2 0401005000 4A 0401018000 4A 0401104000 4A 0401133000 4A 0401134000 4A 0401138000 4A 0401150000 4A Beet , garden , roots Beet , garden , roots-babyfood Burdock Carrot Carrot-babyfood Carrot , juice Celeriac Chicory , roots Ginseng , dried Horseradish Parsley, turnip rooted Parsnip Parsnip-babyfood Radish , roots Radish , Oriental , roots Rutabaga Salsify , roots Turnip , roots Arrowroot , flour Arrowroot , flour

- babyfood Artichoke , Jerusalem Cassava Cassava-babyfood Das h een , corm Ginger Ginger-baby food Ginger , dried Potato , chips Potato , dry (granules/ flakes) Potato , dry (granules/ flakes)-b Potato , flour Potato , flour

- babyfood Potato , tuber , w/peel Potato , tuber , w/peel-babyfood Potato , tuber , w/o peel Potato, tuber , w/o peel-babyfood Sweet potato Sweet potato-babyfood Tanier , corm Turmeric Yam , true Yam bean Beet , garden , tops Chicory , tops Dasheen , leaves Radish , tops Radish , Oriental , tops Salsify , tops Amaranth , leafy Arugula Chrysanthemum , garland Cress , garden Cress, upland Dandelion , leaves Endive 0 . 010000 0 . 010000 0 . 010000 0 . 900000 0 . 900000 0 . 900000 0 . 010000 0 . 900000 0 . 900000 0 . 900000 0 . 900000 0 . 900000 0 . 900000 0 . 010000 0 . 010000 0 . 010000 0 . 900000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 

### Page 12of 19 Adj . Factors Ul #2 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 Comment

### Fluen s ulfone Dietary Ex posure and Ri sk Asse ss ment DP Nu mb er: 0432134 0401204000 4A Lettuce , head 0 . 030000 1 . 000 1 . 000 040120SOOO 4A Lettuce , leaf 0 . 100000 1 . 000 1 . 000 040124SOOO 4A Parsley, leaves 0 . 010000 1 . 000 1 . 000 0401313000 4A Radicchio 0 . 030000 1 . 000 1 . 000 04013SSOOO 4A Spinach 0 . 010000 1 . 000 1 . 000 04013SS001 4A Spinac h- babyfood 0 . 010000 1 . 000 1 . 000 0402076000 4B Cardoon 1 . 000000 1 . 000 1 . 000 04020BSOOO 4B Celery 1 . 000000 1 . 000 1 . 000 04020SS001 4B Celery-baby food 1 . 000000 1 . 000 1 . 000 04020B6000 4B Celery , juice 1 . 000000 1 . 000 1 . 000 04020B7000 4B Celtuce 1 . 000000 1 . 000 1 . 000 04021S2000 4B f'enne l, Florence 1 . 000000 1 . 000 1 . 000 0402322000 4B Rhubarb 1 . 000000 1 . 000 1 . 000 0402367000 4B Swiss chard 1 . 000000 1 . 000 1 . 000 OS01061000 SA Broccoli 0 . 010000 1 . 000 1 . 000 OS01061001 SA Broccoli-babyfood 0 . 010000 1 . 000 1 . 000 OS01062000 SA Broccoli , Chinese 0 . 010000 1 . 000 1 . 000 OS01064000 SA Brussels sprouts 0 . 010000 1 . 000 1 . 000 OS01069000 SA Cabbage 0 . 010000 1 . 000 1 . 000 OS01071000 SA Cabbage , Chinese , napa 0 . 010000 1 . 000 1 . 000 0501072000 SA Cabbage , Chinese , mustard 0 . 010000 1 . 000 1 . 000 OS010S3000 SA Cauliflower 0 . 010000 1 . 000 1 . 000 OS01196000 SA Kohlrabi 0 . 010000 1 . 000 1 . 000 0502063000 SB Broccoli raab 0 . 010000 1 . 000 1 . 000 0502070000 SB Cabbage , Chinese , bok choy 0 . 010000 1 . 000 1 . 000 0502117000 SB Collards 0 . 010000 1 . 000 1 . 000 0502194000 SB Kale 0 . 010000 1.000 1 . 000 OS02229000 SB Mustard greens 0 . 010000 1 . 000 1 . 000 050231SOOO SB Rape greens 0 . 010000 1 . 000 1 . 000 05023B9000 SB Turnip , greens 0 . 010000 1.000 1 . 000 OB01374000 SA Tomat i llo 0 . 010000 1.000 1 . 000 OB01375000 BA Tomato 0 . 010000 1 . 000 1 . 000 OB0137S001 BA Tomato-babyfood 0 . 010000 1 . 000 1 . 000 OB01376000 SA Tomato , paste 0 . 010000 1 . 000 1 . 000 0801376001 BA Tomato , paste-babyfood 0 . 010000 1 . 000 1 . 000 OB01377000 BA Tomato , puree 0 . 010000 1 . 000 1 . 000 OB01377001 BA Tomato , puree-baby food 0 . 010000 1 . 000 1 . 000 OB0137BOOO BA Tomato , dried 0 . 010000 1 . 000 1 . 000 OB0137B001 BA Tomato , dried-babyfood 0 . 010000 1 . 000 1 . 000 OB01379000 BA Tomato , juice 0 . 010000 1 . 000 1 . 000 OB013BOOOO SA Tomato , Tree 0 . 010000 1 . 000 1 . 000 OB0214BOOO BBC Eggplant 0 . 010000 1 . 000 1 . 000 OB02234000 BBC Okra 0 . 010000 1 . 000 1 . 000 OB02270000 BB Pepper , bell 0 . 010000 1 . 000 1 . 000 OB02270001 BB Pepper , bell-babyfood 0 . 010000 1 . 000 1 . 000 OB02271000 SB Pepper , bell, dried 0 . 010000 1 . 000 1 . 000 OB02271001 SB Pepper , bell, dned-babyfood 0 . 010000 1 . 000 1 . 000 OB02272000 SBC Pepper , nonbell 0 . 010000 1 . 000 1 . 000 OB02272001 BBC Pepper , nonbell-babyfood 0 . 010000 1 . 000 1 . 000 OB02273000 BBC Pepper , nonbell , d r ied 0 . 010000 1 . 000 1 . 000 0901075000 9A Canta l oupe 0 . 010000 1 . 000 1 . 000 09011B7000 9A Honeydew melon 0 . 010000 1 . 000 1 . 000 0901399000 9A Watermelon 0 . 010000 1 . 000 1 . 000 0901400000 9A Watermelon , juice 0 . 010000 1 . 000 1 . 000 0902021000 9B Balsam pear 0 . 010000 1 . 000 1 . 000 0902088000 9B Chayote , fruit 0 . 010000 1 . 000 1 . 000 0902102000 9B Chinese waxgourd 0 . 010000 1 . 000 1 . 000 0902135000 9B Cucumber 0 . 010000 1 . 000 1 . 000 090230BOOO 98 Pumpkin 0 . 010000 1 . 000 1 . 000 0902309000 9B Pumpkin , seed 0 . 010000 1 . 000 1 . 000 0902356000 9B Squash , summer 0 . 010000 1 . 000 1 . 000 0902356001 98 Squash , sullUller-babyfood 0 . 010000 1 . 000 1 . 000 0902357000 9B Squash , winter 0 . 010000 1 . 000 1 . 000 0902357001 98 Squash , winter-babyfood 0 . 010000 1 . 000 1 . 000 1307130000 13G Cranberry 0 . 010000 1 . 000 1 . 000 1307130001 13G Cranberry

- babyfood 0 . 010000 1 . 000 1 . 000 1307131000 13G Cranberry, dried 0 . 010000 1 . 000 1 . 000 

### P

age 13of1 9

### Fluensulfo ne 1307132000 13G 1307132001 13G 1307359000 13G 1307359001 13G 1307 360000 l 3G 130736000 1 13G 8601000000 86A 8602000000 869 

### Dietary Expos ure and Risk Asse ss ment Cranberry , juice Cranberry , juice-babyfood Strawberry Strawberry-babyfood Stra wber ry , juice Strawberry , juice -babyf ood Water , direct , all sources Water , indirect , all sources 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 077600 0 . 077600



### Page 14 of 1 9 DP Number : D432 I34 1.100 1 . 100 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000

### Fluen s ulfone Dietary Exposure and Ri sk Assessment DP Number: D432 I34 

### Attachmen t 2: Inp uts used in the c hroni c d ieta ry exposure assess ment fo r fl ue nsu lfo ne. Filename : C : \Users\jcowins\Desktop\DEEM F i l es\Fluensulfo ne\Chroni c Fluensulfone

- new . R08 Che mical : Fluensulfon e RfD(Chronic) : . 1 mg/kg bw/day NOEL(C h ro n ic) : 0 mg/kg bw/day RfD(Acute) : . 16 mg/kg bw/day NOEL(Acute ) : 0 mg/kg bw/day Date creat ed/ l ast modified : 04

- 26

- 2016/15 : 25 : 41 Program ver . 3 . 16 , 03-08 -d Crop EPA Code Grp Commodity Name Def Res (ppm) 0101050000 lAB 0101050001 lAB 0101067000 lAB 0101078000 lAB 010107800 1 !AB 0101079000 l AB 0101084000 lAB 0101100000 lAB 0101168000 lAB 0101190000 !AB 0101250000 lAB 0101251000 lAB 0101251001 lAB 0101314000 lAB 0101316000 lAB 0101327000 lAB 010133 1 000 lAB 0101388000 lAB 01030 15000 lCD 0103015001 lCD 0103017000 lCD 0103082000 lCD 0103082001 lCD 0103139000 lCD 0103166000 lCD 0103166001 lCD 0103167000 lCD 0103296000 lC 0103297000 lC 010329700 1 lC 0103298000 lC 010329800 1 lC 0103299000 lC 010329900 1 lC 0103300000 lC 0103300001 lC 0103366000 lCD 0103366001 lCD 0103371000 lCD 0103387000 lCD 0103406000 lCD 0103407000 lCD 020005 1000 2 0200 101000 2 0200 140000 2 0200315000 2 02003 17000 2 0200332000 2 0401005000 4A 0401018000 4A 0401104000 4A 0401133000 4A 0401134000 4A 0401138000 4A 0401150000 4A Beet , garden , roots Beet , garden , roots-babyfood Burdock Carrot Carrot-babyfoo d Carrot , juice Celeriac Chicory , roots Ginseng , dried H

orseradis h Parsley , turni p rooted Parsnip Parsnip-babyfood Radish , roots Radish , Oriental , roots Rutabaga Salsify , roots Turnip , roots Arrow root , flour Arrowroot , flour -bab yfood Artichoke , Jerusalem Cassava Cassava-babyfood Dasheen , corm Ginger Ginger-baby food Ginger , dried Potato , chips Potato , dry (granules/ f lakes) Potato , dry (granules/ f lakes)-b Potato , flo ur Potato , flo ur - babyfood Potato , tu ber , w/peel Potato , tu ber , w/peel-babyfood Potato , tu ber , w/o peel Potato , tuber , w/o peel

- babyfood Sweet potato Sweet potato-baby food Tanier , corm Turmeric Yam , true Yam bean Be et , garde n , tops Chicory , tops Das h ee n , leaves Radish , tops Radish , Oriental , tops Salsify , tops Amaranth , leafy Arugula Chrysanthemum , garland Cress , garden Cress , upland Da nd elion , leaves Endive 0 . 010000 0 . 010000 0 . 010000 0 . 900000 0 . 900000 0 . 900000 0 . 010000 0 . 900000 0 . 900000 0 . 900000 0 . 900000 0 . 900000 0 . 900000 0 . 010000 0 . 010000 0 . 010000 0 . 90000 0 0 . 010000 0 . 010000 0 . 0 1 0000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 0 10000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 0 1 0000 0 . 0 10000 0 . 010000 0 . 010000 0 . 010000 0 . 0 1 0000 0 . 0 1 0000 0 . 0 10 000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 0 1 0000 0 . 0 10000 

### Page 15of 1 9 Ad j . Factors Comme nt U H2 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1. 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000

### Fluensulfone Dietary Exposure and Risk Assessment DP Numbe r : D432 I 34 0401204000 4A Lettuce , head 0 . 030000 1 . 000 1 . 000 0401205000 4A Lettuce , leaf 0 . 100000 1 . 000 1 . 000 0401248000 4A Parsley , leaves 0 . 010000 1 . 000 1 . 000 0401313000 4A Radicchio 0 . 030000 1 . 000 1 . 000 04013SS000 4A Spinach 0 . 010000 1 . 000 1 . 000 04013SS001 4A Spinach-babyfood 0 . 010000 1 . 000 1 . 000 0402076000 48 Cardoon 1 . 000000 1 . 000 1 . 000 0402085000 48 Celery 1 . 000000 1 . 000 1 . 000 040208S001 48 Celery-babyfood 1 . 000000 1 . 000 1 . 000 0402086000 48 Celery , juice 1 . 000000 1 . 000 1 . 000 0402087000 48 Celtuce 1 . 000000 1 . 000 1 . 000 04021S2000 4B Fennel , Fl orence 1 . 000000 1 . 000 1 . 000 0402322000 48 Rhubarb 1 . 000000 1 . 000 1 . 000 0402367000 4B Swiss chard 1 . 000000 1 . 000 1 . 000 OS01061000 SA Broccoli 0 . 010000 1 . 000 1 . 000 OS01061001 SA Broccoli

- babyfood 0 . 010000 1 . 000 1 . 000 0501062000 SA Broccoli , Chinese 0 . 010000 1 . 000 1 . 000 0501064000 SA Brussels sprouts 0 . 010000 1 . 000 1 . 000 0501069000 SA Cabbage 0 . 010000 1 . 000 1 . 000 0501071000 SA Cabbage , Chinese , napa 0 . 010000 1 . 000 1 . 000 OS01072000 SA Cabbage , Chinese , mustard 0 . 010000 1 . 000 1 . 000 0501083000 SA Caul iflower 0 . 010000 1 . 000 1 . 000 OS01196000 SA Kohlrabi 0 . 010000 1 . 000 1 . 000 OS02063000 SB Broccoli raab 0 . 010000 1 . 000 1 . 000 0502070000 SB Cabbage , Chinese , bok choy 0 . 010000 1 . 000 1 . 000 0502117000 SB Collards 0 . 010000 1 . 000 1 . 000 0502194000 58 Kale 0 . 010000 1 . 000 1 . 000 0502229000 5B Mustard greens 0 . 010000 1 . 000 1.000 0502318000 SB Rape greens 0 . 010000 1 . 000 1 . 000 0502389000 SB Turnip , greens 0 . 010000 1 . 000 1 . 000 0801374000 SA Tomatillo 0 . 010000 1 . 000 1 . 000 080137SOOO BA Tomato 0 . 010000 1 . 000 1 . 000 080137S001 BA Tomato

- baby food 0 . 010000 1 . 000 1 . 000 0801376000 BA Tomato , paste 0 . 010000 1 . 000 1 . 000 0801376001 BA Tomato , paste - baby food 0 . 010000 1 . 000 1 . 000 0801377000 SA Tomato, puree 0 . 010000 1 . 000 1 . 000 0801377001 SA Tomato , puree-baby food 0 . 010000 1 . 000 1 . 000 0801378000 SA Tomato , dried 0 . 010000 1.000 1 . 000 0801378001 8A Tomato , dried -bab yfood 0 . 010000 1 . 000 1 . 000 0801379000 8A Tomato , juice 0 . 010000 1 . 000 1 . 000 0801380000 BA Tomato , Tree 0 . 010000 1 . 000 1.000 0802148000 8BC Eggplant 0 . 010000 1 . 000 1 . 000 0802234000 BBC Okra 0 . 010000 1 . 000 1 . 000 0802270000 8B Pepper , bell 0 . 010000 1 . 000 1 . 000 0802270001 8B Pepper , bell-babyfood 0 . 010000 1 . 000 1 . 000 0802271000 8B Pepper , bell , dried 0 . 010000 1 . 000 1 . 000 0802271001 88 Pepper , bell , dried-baby food 0 . 010000 1 . 000 1 . 000 0802272000 SBC Pepper , nonbel l 0 . 010000 1 . 000 1 . 000 0802272001 8BC Pepper , nonbell-babyfood 0 . 010000 1 . 000 1 . 000 0802273000 SBC Pepper , nonbell , dried 0 . 010000 1 . 000 1 . 000 0901075000 9A Cantaloupe 0 . 010000 1 . 000 1 . 000 0901187000 9A Honeydew melon 0 . 010000 1 . 000 1 . 000 0901399000 9A Watermelon 0 . 010000 1 . 000 1 . 000 0901400000 9A Watermelon , juice 0 . 0 10000 1 . 000 1 . 000 0902021000 98 Balsam pear 0 . 010000 1 . 000 1 . 000 0902088000 98 Chayote , fruit 0 . 010000 1 . 000 1 . 000 0902102000 98 Chinese waxgourd 0 . 010000 1.000 1 . 000 090213SOOO 98 Cucumber 0 . 010000 1 . 000 1 . 000 0902308000 98 Pumpkin 0 . 010000 1 . 000 1 . 000 0902309000 98 Pumpkin , seed 0 . 010000 1 . 000 1 . 000 09023S6000 9B Squash , surruner 0 . 010000 1 . 000 1 . 000 0902356001 9B Squash , surruner-babyfood 0 . 010000 1 . 000 1. 000 0902357000 98 Squash , winter 0 . 010000 1 . 000 1.000 0902357001 98 Squash , winter-babyfood 0 . 010000 1 . 000 1 . 000 1307130000 13G Cranberry 0 . 010000 1 . 000 1 . 000 1307130001 13G Cra nberry-babyfood 0 . 010000 1 . 000 1.000 1307131000 13G Cranberry , dried 0 . 010000 1 . 000 1 . 000 

### Page 16of19

### Fluensulfonc 130713 2000 13G 130 713200 1 13G 1307359000 13G 1307359001 13G 1307360000 13G 1307360001 13G 8601000000 86A 8602000000 868 

### Dietary Exposure and Risk Assessment Cranberry , juice Cranberry , j u ice-babyfood Strawberry Strawberry-babyfood Strawberry , juice Strawberry , juic e-babyfood Water , direct , all sources Water , indirect , all sources



### Page 17of19 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 010000 0 . 052500 0 . 052500 

### DP Number : D432 I 34

1 . 100 1 . 100 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000

### Fluen s ulfone Dietary E xposure and Risk Asse ss ment DP Number: D432134 

### Attaclunent 3: Summary of acute dietary exposure and risk estimates for fluensulfone. OPP Health Effects Division DEEM-fC I D ACUTE A n a l y s is for fLUENSULfONE Residue file : Acute f luensulfo ne- n e w . R08 Analysis Date : 03

- 28

- 2016/11 : 29 : 58 RAC/ff intake summed over 24 hours Run Comment : " " 

### Ver . 3 . 18 , 03-08-d NH A N

ES 2003

- 2008 2-Day Adj u st me nt factor #2 N OT used . Residue f ile dated : 04-26-2016/15 : 22 : 09



## ======================= ========= = =

=

=========== =========== = ===================== Summary c a lc u lations

-- per capita : 95th Percentile 99th Percentile 99 . 9th Pe r centile Exposure ., aRfD Exposure aRfD Exposure !l aRfD



# ---------- --- ---- - 

### ---- ----- - ---- -- -- 

# ------- -- - -------- Total us Population : 0 . 00 4 809 3 . 01 0 . 008011 5 . 01 0 . 014867 9 . 29 All Infants : 0 . 014794 9 . 25 0 . 019945 12 . 47 0 . 026488 16 . 55 Children 1-2 : 0 . 008369 5 . 23 0 . 013840 8 . 65 0 . 026403 16 . 50 Children 3-5 : 0 . 006513 4 . 07 0 . 009656 6 . 03 0 . 014524 9 . 08 Children 6-12 : 0 . 004649 2 . 91 0 . 007463 4 . 66 0 . 011266 7 . 04 Youth 13

- 19 : 0 . 003774 2 . 36 0 . 006061 3 . 79 0 . 009235 5 . 77 Adults 20-49 : 0 . 004564 2 . 85 0 . 006547 4 . 09 0 . 009139 5 . 71 Ad u lts 50-99 : 0 . 004165 2 . 60 0 . 006055 3 . 78 0 . 00902 4 5 . 64 female 13

- 49 : 0 . 004601 2 . 88 0 . 006488 4 . 06 0 . 008989 5 . 62



### Page 18of19

### Fluen s ulfon e Dietary Exposure and Risk Assessment DP Number: 0432134 

### Attachment 4: Summary of chronic dietary exposure and ri s k estimates for fluensulfone. OPP Health Effects Division Ver . 3 . 16 , 03

- 08

- d DEEM-FCID Chronic analysis for FLUENSULFONE NHANES 2003

- 2008 2

- day Residue file name : C : \Users\jcowins\Desktop\DEEM Files\Fluensulfone\Chronic Fluensulfone

new . R08 AdJUStment factor 

### H2 NOT used . Analysis Date 03

- 28

- 2016/13 : 38 : 52 Residue file dated : 04-26

- 2016/15 : 25 : 41 Reference dose CRfD , Chronic) 

### = . 1 mg/kg bw/day 

## ==================================== ===========================================

Population

Subgroup Total US Population Hispanic Non-Hisp-White Non-Hisp-Black Non-Hisp-Other Nursing Infants Non-Nursing Infants Female 13+ PREG Children 1-6 Children 7-12 Male 13-19 Female 13-19/NP Male 20+ Female 20+/NP Seniors 55+ All Infants Female 13-50 Children 1-2 Children 3-5 Children 6-12 Youth 13-19 Adults 20-49 Adults 50-99 Female 13-49 Total exposure by population subgroup Total Exposure mg/kg body w t/day 0 . 001335 0 . 001301 0 . 001370 0 . 001063 0 . 001593 0 . 001845 0 . 004848 0 . 001190 0 . 001946 0 . 001167 0 . 000892 0 . 000993 0 . 001204 0 . 001365 0 . 001282 0 . 003921 0 . 001278 0 . 002283 0 . 001811 0 . 001234 0 . 000943 0 . 001279 0 . 001297 0 . 001276



### Page 19 of 1 9 Percent of Rfd 1. 3% 1. 3% 1. 4% 1.1% 1. 6% 1.8 % 4.8 % 1. 2% 1. 9% 1.2% 0 . 9% 1.0 % 1.2% 1. 4 % 1. 3% 3 . 9% 1. 3 % 2 . 3 % l. 8 % 1.2% 0 . 9% 1. 3% 1. 3% 1. 3%