English translation of Exclusive Regional Distribution Agreement



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 Exhibit 10.19 
 ALPROSTADIL INJECTION 
 (PROSTAGLANDIN E1) 
 EXCLUSIVE REGIONAL DISTRIBUTION AGREEMENT 
  

			
	Party A:	 	Jilin Yuhua Pharmaceutical Co., Ltd. (hereinafter referred to as “Party A”)
		
	Address:	 	No. 2069 Fuzhi Road, Jingyuetan Tourist Economic Development Zone, Changchun City
		
	Legal representative:	 	Dong Hongbo
		
	Party B:	 	Liaoning Nuokang Medicines Co., Ltd. (hereinafter referred to as “Party B”)
		
	Address:	 	No. 219, Qingnian Street, Shenhe District, Shenyang City
		
	Legal representative:	 	Xue Baizhong

  

	1.	Designation 

  

	1.	In accordance with this Agreement, Party A hereby authorizes Party B as a sole agency for its product, namely alprostadil injection (prostaglandin E1)(hereinafter
referred to as the “Agency Product”), in the territory of the People’s Republic of China (including the regions of Hong Kong, Macau, and Taiwan) other than Jilin and Heilongjiang provinces (hereinafter referred to as the
“Agency Sales District”) to be responsible for the purchase, marketing and sale of the product listed herein on the conditions and terms of this Agreement. 

  

	2.	Within the term hereof, Party A shall not separately appoint any other agents or distributors in any manner or for any reasons to the Agency Sales District of Party B
mentioned above, nor shall it sell the Agency Products set forth herein by itself in any manner or for any reasons. 

  

	2.	Price of Agency Product and its Settlement Method 

  

	1.	The price applicable to the sale of the Agency Product from Party A to Party B shall be as follows (See “Table 1”): 

 Table 1: Catalogue of the Agency Product and its Supply Price 
 Unit: Renminbi/piece 
  

													
	 Common Name
	  	  Production  
Unit	  	Specifications  
for Packing	  	Unit	  	Retail Price  	 	Supply Price  	 	Remark  
	 Alprostadil injection
	  	Party A	  		  		  	[****]†	 	[****]†	 	

  

	Note:	In the event of any price adjustment of the Agency Products due to national policies or any change in the cost of the Agency Products manufactured by Party A,
changes shall also be made to the supply 

  

	†	 This portion of the contract has been omitted and filed separately with the Securities and Exchange Commission, pursuant to Rule 406 under the
Securities Act of 1933, as amended. A confidential treatment has been granted with respect to the omitted portion. 


  

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	    	price of the Agency Products accordingly with reference to the current profit margin of the Agency Products to which each of Party A and Party B is entitled. The
specific price of the Agency Products shall be separately confirmed by Party A and Party B through consultation. 

  

	2.	Following the consultation of both parties, the deadline and method of settlement for the Agency Products shall be set as follows: upon receipt from Party B of 60% of
the prepayment for products and a plan of expected demand, Party A shall complete the procurement and production of products and notify Party B in writing within 30 days thereafter; Party B shall, upon receipt of the written notice from Party A,
settle the remaining payment in full and Party A shall issue to Party B an invoice in respect thereof. Party B shall, within 10 days of the receipt of such invoice from Party A, take delivery of products from the warehouse designated by Party A with
the presentation of the invoice. 

  

	3.	Rights, Liabilities and Obligations of Party A 

  

	1.	Within the term hereof, Party A shall provide Party B with all lawful documents and complete all formalities in relation to the distribution of the Agency Products.


  

	2.	Within the term hereof, Party A shall assist Party B or any third party designated by it in dealing with such matters as tendering, bidding and linking to websites in
the Agency Sales District, and shall provide tender documents and information in a timely and accurate manner. 

  

	3.	Within the term hereof, Party A shall have no right to sub-transfer to any third party all or part of its rights or obligations under this Agreement unless with the
written consent of Party B. 

  

	4.	Within the term hereof, Party A shall provide Party B with qualified Agency Products hereunder in accordance with the provisions of this Agreement. If Party B discovers
any damages to or losses of the Agency Products when taking delivery of the products, it shall, subject to confirmation by the parties, accept the actual number of products that have not been damaged or lost by giving its signature.


  

	5.	Within the term hereof, any pollution and shortage of or damage to the Agency Products resulting from a lack of strict management on storage and transportation of
product in the course of sale, and any overstocking of the Agency Products due to mismanagement shall be borne by Party B after such Agency Products distributed by Party B are inspected, accepted and then sent to warehouses. Party A shall be liable
for all damages in connection with the quality of the Agency Products in the course of sale, as well as any other losses suffered by Party B arising therefrom (including but not limited to direct and indirect economic losses). Party A shall offer
replacement of products and bear any cost in relation thereto. In the event of any change in price of the Agency Products due to force majeure, the parties shall make adjustments to the supply price of the Agency Products through consultation, save
for any delay in delivery of products or any other breaches of Party A occurred prior to force majeure. 

  

	6.	Within the term hereof, Party A shall offer cooperation to Party B for all sale activities undertaken by the distributors designated by Party B in the Agency Sales
District. 

  

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	7.	Within the term hereof, Party A shall not transfer the ownership of the Agency Products of their kind hereunder unless with the written consent of Party B.


  

	8.	Within the term hereof, Party B or its designated third party shall be entitled to use (without consideration) the intellectual property rights of Party A, including
without limitation, trademarks (trade names, logos), patents, copyrights, and trade secrets, for its sale of the Agency Products in the Agency Sales District. 

  

	4.	Rights, Liabilities and Obligations of Party B 

  

	1.	Within the term hereof, Party B shall, within 3 days of the date of this Agreement, pay to Party A the amount of RMB16 million in a lump sum
as an agency fee for its being appointed as a sole agency of the Agency Product in the Agency Sales District for a term of 10 years as mentioned in Article 8 hereof. 

  

	2.	 Within the term hereof, Party B shall submit to Party A a plan of expected demand for next month by the first 5 days of each month, and Party A shall
provide Party B with qualified Agency Products by the 15th
day of the following month. 


  

	3.	Within the term hereof, Party B shall be strictly prohibited from selling counterfeit and fake Agency Products, and shall take an initiative itself to protect the brand
name and image of Party A. 

  

	4.	Following the proper performance and expiry of this Agreement, Party B shall have the priority right to renew an exclusive regional distribution agreement with Party A
for the sale of the Agency Product specified herein on the same conditions offered by others. 

  

	5.	Party B shall provide Party A with the relevant valid documents (business license, drug operating permit, GSP certificate, organization code certificate, tax
registration certificate, general taxpayers registration certificate, copies of the identity card of salespersons and letters of appointment of sub-agency companies). 

  

	6.	Party B shall make its own investment for market development, and shall design and promote awareness tools, promotional items and materials relating to the Agency
Product strictly according to national laws and regulations. Any marketing fee of channels shall be undertaken by Party B. 

  

	7.	Within the term hereof, Party B shall have the right to select and designate any distributor and marketing mode for the Agency Sales District in light of the specific
sales of the Agency Products without the consent of Party A. 

  

	8.	Within the term hereof, Party B shall not sell any agency product of third parties that is identical with that of Party A in the Agency Sales District.


  

	5.	Breaches of Party A and Party B and their Treatment 

  

	1.	If, within the term hereof, Party A fails to provide Party B with the Agency Products pursuant to this Agreement due to its own faults or for other reasons such as any


  

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	    	change in national policies, or approvals, or if the Agency Products are expressly prohibited by China for circulation, Party B shall have the right to opt for the
termination of this Agreement and Party A shall refund to Party B any agency fee for the remaining term of this Agreement, or Party B shall, within 30 days after the occurrence of the above situation, negotiate with Party A to sign a separate
supplemental agreement. 

  

	2.	If, within the term hereof, Party A terminates or discharges this Agreement without authorization, or appoints any other agents or distributors for the Agency Product
to the Agency Sales District of Party B in any manner or for any reasons, or sells the Agency Product hereunder by itself in any manner or for any reasons without the written consent of Party B, Party A shall refund to Party B any agency fee for the
remaining term of this Agreement and shall indemnify Party B against all losses suffered by it arising therefrom (which losses shall be determined on the basis of 3 times the profits expected to be generated by Party B in the remaining term of this
Agreement). If Party B sells any agency product of third parties that is identical to that of Party A in the Agency Sales District without the written consent of Party A, Party B shall not have the right to require Party A to refund any agency fee
for the remaining term of this Agreement and shall indemnify Party A against all losses suffered by it arising therefrom (which losses shall be determined on the basis of 3 times the profits expected to be generated by Party A in the remaining term
of this Agreement). 

  

	3.	Where the Agency Products provided by Party A to Party B do not comply with national requirements, Party B shall have the right to demand for the return or replacement
of such products. Party A shall make the replacement or refund any payment for the products and shall also bear all costs paid by Party B arising therefrom. In the event of any loss suffered by Party B, Party A shall indemnify Party B against all
direct and indirect economic losses. If Party B refuses to accept any qualified Agency Products provided by Party A that meet the national requirements without causes, Party B shall indemnify Party A against all direct and indirect economic losses
suffered by it arising therefrom. 

  

	4.	When taking delivery of products by Party B from the warehouse designated by Party A in accordance with Article 6(1) hereof, if Party A delays in the delivery of
products (for more than 5 days), it shall pay to Party B a penalty which will be calculated at 0.5% of the total amount of the products on a daily basis. If Party B, upon receipt of an invoice from Party A pursuant to Article 6(1) hereof,
delays in taking delivery of products from the warehouse designated by Party A (for more than 5 days), it shall pay to Party A a penalty which will be calculated at 0.5% of the total amount of the products on a daily basis.


  

	5.	If, within the term hereof, any loss suffered by Party B or its designated third parties is due to the fault of the agencies of Party A or its authorized agencies which
sell the Agency Products in Jilin province and/or Heilongjiang province (including without limitation, product speculation, sales across districts and dumping products at low prices), Party A shall be liable for all losses arising therefrom. If any
loss suffered by Party A or its authorized agencies which sell the Agency Product in Jilin province and/or Heilongjiang province is due to the fault of Party B or its designated third parties (including without limitation, product speculation, sales
across districts and dumping products at low prices), Party B shall be liable for all losses arising therefrom. 

  

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	6.	Delivery and Acceptance of Products, and Undertaking of Freight Charges 

  

	1.	Party B shall be responsible for the transportation of products. Upon receipt of an invoice from Party A, Party B shall take delivery of products from the warehouse
designated by Party A with the presentation of such invoice. 

  

	2.	Each batch of the Agency Products delivered by Party A shall meet the specifications set out in “Table 1”. Upon delivery of each batch of the Agency Products,
Party B shall immediately inspect the products so as to ascertain whether the products meet the requirements of sales agreement or this Agreement. In the event of any inconsistency, Party B shall, within 7 working days of the receipt of the Agency
Products, serve a written notice to Party A to refuse the acceptance of the Agency Products that fail to meet the relevant requirements, or require Party A to make replacement thereof. Any costs arising therefrom shall be paid by Party A. The above
notice shall specify which parts of the Agency Products are not in compliance with the specifications. Party A shall, within 7 days of the receipt of the written notice from Party B, take measures to withdraw or replace the products. Otherwise, the
Agency Products that do not comply with the specifications will not be counted into the total quantity of products delivered. 

  

	3.	If, in the normal course of sale, Party B discovers any shortage of or damage to the Agency Products in their original packing boxes, Party A shall, subject to
confirmation of both parties, make up the same number of the Agency Products that are in shortage and damaged, and shall bear any transportation cost in connection therewith. 

  

	7.	Force Majeure and Disputes Resolution 

  

	1.	If part of this Agreement cannot be performed due to any events of force majeure stipulated by laws, any liabilities arising from it shall be released. Where none of
the provisions of this Agreement can be performed, this Agreement shall be terminated and no party shall be liable to it. 

  

	2.	Any dispute or conflict arising out of this Agreement shall be resolved by the parties through friendly consultation. In the event that no agreement can be reached
through consultation, either party can bring an action to the people’s court at the place where Party B is located. 

  

	3.	This Agreement shall be governed by the laws of the People’s Republic of China. 

  

	8.	Term of this Agreement 

  

	1.	This Agreement shall become effective exactly six months after it is signed or on the date Party A provides Party B with the first batch of qualified Agency Products in
accordance with this Agreement, whichever is earlier. If this Agreement cannot take effect due to any reason other than the fault of either party, Party A and Party B shall, within 30 days after the occurrence of the above situation, confirm through
consultation whether to terminate or discharge this Agreement or sign a separate supplemental agreement. 

  

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	2.	During the period from the date of this Agreement to the effective date stipulated in Article 8(1) hereof, Party B shall have the right to opt for the discharge this
Agreement unilaterally at any time, and Party A shall immediately refund the amount of RMB16 million paid by Party B under Article 4(1) hereof. 

  

	3.	This Agreement shall have a term (of 10 years) from the effective date to 30 June 2019. Party A shall notify Party B in writing of the expiration of this
Agreement at least one month prior to its expiry. 

  

	4.	Party A and Party B shall, within 30 days of the effective date of this Agreement, separately sign a formal exclusive regional distribution agreement for the sale of
the Agency Products in the Agency Sales District. 

  

	9.	Training and Post-sales Service 

  

	1.	Without prejudice to the normal business operation of Party B, Party A shall regularly or from time to time supervise the business activities of Party B or its
designated third parties. 

  

	2.	Within the term hereof, Party A shall provide training courses on business operation for Party B or its designated third parties from time to time. Any training costs
shall be borne by Party B. Within the term hereof, Party A shall continuously provide Party B or its designated third parties with guidance on marketing, services or technologies as required for business development, and shall provide Party B with
the necessary assistance. 

  

	3.	With regard to any Agency Products provided by Party A to Party B or its designated third parties, Party A shall offer quality assurance service strictly in accordance
with the letter of quality assurance provided by Party A and the relevant national requirements. 

  

	10.	Representations and Warranties 

  

	(A)	By Party A: 

  

	1.	Party A is an enterprise duly incorporated and validly existing under the laws of the People’s Republic of China, and shall have the authority to execute and the
ability to perform this Agreement. 

  

	2.	At the time of signing this Agreement, no courts, arbitral bodies, administrative or regulatory authorities have made any judgment, ruling, verdict or specific
administrative act that has material adverse impacts on the performance by Party A of this Agreement. 

  

	3.	The execution and performance of this Agreement shall not have conflicts with any agreement or other contracts or documents to which Party A is a party.


  

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	4.	All internal authorization procedures required to be taken by Party A for the execution of this Agreement have been completed. The signatory of this Agreement is the
legal representative or authorized representative of Party A. This Agreement shall be legally binding on Party A once it becomes effective. 

  

	(B)	By Party B: 

  

	1.	Party B is an enterprise duly incorporated and validly existing under the laws of the People’s Republic of China, and shall have the authority to execute and the
ability to perform this Agreement. 

  

	2.	At the time of signing this Agreement, no courts, arbitral bodies, administrative or regulatory authorities have made any judgment, ruling, verdict or specific
administrative act that has material adverse impacts on the performance by Party B of this Agreement. 

  

	3.	The execution and performance of this Agreement shall not have conflicts with any agreement or other contracts or documents to which Party B is a party.


  

	4.	All internal authorization procedures required to be taken by Party B for the execution of this Agreement have been completed. The signatory of this Agreement is the
legal representative or authorized representative of Party B. This Agreement shall be legally binding on Party B once it becomes effective. 

  

	11.	Confidentiality 

  

	    	Party A and Party B undertake that they will keep in confidence any documents and materials of the other party that come to their knowledge and cannot be obtained from
public channels during the discussion, execution and performance of this Agreement (including without limitation, trade secrets, company plan, operation activities, financial information, technical information, business information and other trade
secrets, collectively referred to as the “Trade Secrets”). Without the consent of the party who originally provides such information and documents, the other party shall not divulge all or part of the Trade Secrets to any third
parties, unless otherwise required by laws and regulations or otherwise agreed by the parties. The confidentiality period shall be for a term of 10 years from the discharge or termination of this Agreement. 

  

	12.	Miscellaneous 

  

	1.	This Agreement is executed in two originals. Party A and Party B shall each keep one copy. 

  

	2.	This Agreement shall not be regarded as a basis for delivery of products. Party B shall sign a separate sales agreement for the purchase of products from Party A each
time. 

  

	3.	If Party A needs to make an overall price adjustment due to the factors such as national policies or any change in the production costs of the Agency Products, it shall
notify Party B in writing at least 15 days prior to the adjustment. Party A and Party B shall jointly negotiate the specific supply price of the Agency Product. 

  

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	4.	This Agreement shall be formed after it is signed and affixed with common seal by the respective authorized representatives of Party A and Party B.


 (No text below) 
  

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 (Signature Page) 
 Party A: Jilin Yuhua Pharmaceutical Co., Ltd. [Chop affixed] 
 Signed by the legal representative or authorized representative: /s/ Dong Hongbo 
 Date:
28 December 2008 
 Party B: Liaoning Nuokang Medicines Co., Ltd. [Chop affixed] 
 Signed by the legal representative or authorized representative: /s/ Xue Baizhong 
 Date: 28 December 2008 
 Place: Shenyang, China 
  

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 ALPROSTADIL INJECTION

 (PROSTAGLANDIN E1) 
 SUPPLEMENTAL AGREEMENT TO 
 THE EXCLUSIVE REGIONAL DISTRIBUTION AGREEMENT

  

			
	Party A:	  	Jilin Yuhua Pharmaceutical Co., Ltd. (hereinafter referred to as “Party A”)
	Address:	  	No. 2069 Fuzhi Road, Jingyue Economic Development Zone, Changchun
	Legal representative:	  	Zhao Donghui
	Party B:	  	Liaoning Nuokang Medicines Co., Ltd. (hereinafter referred to as “Party B”)
	Address:	  	No. 219, Qingnian Street, Shenhe District, Shenyang City
	Legal representative:	  	Xue Baizhong

  

	1.	Whereas 

  

	1.	Party A and Party B entered into the Exclusive Regional Distribution Agreement for Alprostadil Injection (Prostaglandin E1) (hereinafter referred to as the
“Agreement”) on 28 December 2008, pursuant to which Party A authorized Party B as a sole agency for its product, namely alprostadil injection (prostaglandin E1)(hereinafter referred to as the “Agency Product”),
in the territory of the People’s Republic of China (including the regions of Hong Kong, Macau, and Taiwan) other than Jilin and Heilongjiang provinces (hereinafter referred to as the “Agency Sales District”).


  

	2.	Within the term hereof, Party A shall not separately appoint any other agents or distributors in any manner or for any reasons to the Agency Sales District of Party B
mentioned above, nor shall it sell the Agency Products set forth herein by itself in any manner or for any reasons. 

  

	3.	Article 8(1) of the Agreement stipulates that the Agreement shall become effective exactly six months after it is signed or on the date Party A provides Party B with
the first batch of qualified Agency Products in accordance with the Agreement, whichever is earlier. If the Agreement cannot take effect due to any reason unrelated to either party, Party A and Party B shall, within 30 days after the occurrence of
the above situation, confirm through consultation whether to terminate or discharge the Agreement or sign a separate supplemental agreement. 

 [Chop affixed] 
  

	2.	Supplemental and Revised Provisions 

 Based on the above situation and in accordance with the Contract Law of the People’s Republic of China and the Measures on the Administration of Drugs of the People’s Republic of
China, Party A and Party B have agreed on the following supplemental and revised provisions in respect of the Agreement after friendly consultation: 
  

	1.	Article 8(1) of the Agreement shall be revised as follows: “This Agreement shall become effective exactly twelve months after it is signed or on the date Party A
provides Party B with the first batch of qualified Agency Products in accordance with 








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 this Agreement, whichever is earlier.
If this Agreement cannot take effect due to any reason unrelated to either party, Party A and Party B shall, within 30 days after the occurrence of the above situation, confirm through consultation whether to terminate or discharge this Agreement or
sign a separate supplemental agreement.” 
  

	2.	A sub-clause shall be added to Article 12 of the Agreement as Article 12(5): “In accordance with the relevant national laws and regulations, Party A and Party B
may enter into a supplemental agreement subject to their agreement after consultation. The supplemental agreement, which forms an integral part of this Agreement, shall have the same legal effect as this Agreement. In the event of any inconsistency
between the relevant provisions of this Agreement and the supplemental agreement, the supplemental agreement shall prevail.” 

  

	3.	This supplemental agreement shall become effective once it is signed and affixed with common seal by Party A and Party B. 

 (No text below) 







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 (Signature Page) 
 Party A: Jilin Yuhua Pharmaceutical Co., Ltd. [Chop affixed] 
 Signed by the legal representative or authorized representative: /s/ Dong Hongbo 
 Date:
28 June 2009 
 Party B: Liaoning Nuokang Medicines Co., Ltd. [Chop affixed] 
 Signed by the legal representative or authorized representative: /s/ Xue Baizhong 
 Date: 28 June 2009 
 [Chop of Liaoning Nuokang 
 Medicines Co., Ltd. Affixed] 
 Place: Shenyang, China