2

Executive Summary

The Health Effects Division Cypermethrin Risk Assessment Team has evaluated the database 

and the most recent human health risk assessments for the insecticides cypermethrin and zetacypermethrin. HED performed this evaluation in order to determine the scope of work necessary 

to support the established tolerances and existing registrations. The primary sources of 

information for this evaluation were recent human health risk assessments written for the 

chemicals.

Cypermethrin and zeta-cypermethrin products are registered for use on a wide variety of 

agricultural and residential sites and are formulated as a wide variety of end use products with up 

to 40% of active ingredient. In residential settings, the cypermethrins are applied using common 

hand-held equipment and ready-to-use devices. On the various agricultural crops, up to 8 

applications may be made per season using common agricultural equipment.

The synthetic pyrethroid insecticide cypermethrin [(±) α-cyano-(3-phenoxyphenyl)methyl (±-cis, 

trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate] is a racemic mixture of 

eight isomers (each with percentages of 11-14%). Zeta-cypermethrin is an enrichment of four 

more efficacious isomers, and is therefore more insecticidally potent. While cypermethrin and 

zeta-cypermethrin are separate active ingredients, each registered in separate end-use products, 

they are included together in this risk assessment because of the close similarity of their uses, 

toxicity, and chemical characteristics. In this scoping document, the term “cypermethrins” is 

used when referring to both cypermethrin and zeta-cypermethrin, whereas cypermethrin and 

zeta-cypermethrin are used when referring to the specific end-use products described above. 

HED may need to reassess the endpoints and doses used for human health risk assessments for 

the cypermethrins. Based on a number of new use registration actions currently under review in 

HED, new endpoints and doses may be selected for the registration review risk assessment. The 

dose and endpoint selection process will rely on toxicology studies submitted in support of both 

cypermethrin and zeta-cypermethrin.

The toxicology database for the cypermethrins is complete including an immunotoxicity study 

and a developmental neurotoxicity (DNT) study. Acute toxicity studies conducted with the 

cypermethrins indicate they are moderately acutely toxic via the oral route and have low toxicity 

via the dermal and inhalation routes. They are mildly irritating to the eyes and skin and are not 

dermal sensitizers. Endpoints for risk assessment are generally based on neurotoxicity, which 

has been observed consistently across species; however, toxicity did not increase with an 

increased duration of exposure. 

A screening level cumulative risk assessment was recently conducted for pyrethroids, in which 

the Food Quality Protection Act (FQPA) Safety Factor of 3X was retained for children < 6 years

of age based on age-dependent pharmacokinetics (USEPA, 2011). The Safety Factor was 

reduced to 1X for adults and children ≥ 6. For new use assessments and during registration 

review, the FQPA factor for the cypermthrins will be evaluated in light of the cumulative risk 

assessment decision and other available data. 
3

Cypermethrin has been classified as a possible human carcinogen, based on an increased 

incidence of lung adenomas and combined adenomas and carcinomas in female mice. However, 

the chronic toxicity endpoints selected for risk assessment are considered protective of any 

cancer risks. Dermal assessments have not been completed for adults exposed to cypermethrins 

via the dermal route due to a lack of systemic toxicity in the 21-day dermal study in the rat; 

however, due to potential susceptibility of offspring, HED conducted dermal assessments for 

children. This approach will be reconsidered during registration review based on the weight of 

evidence from the toxicology database. 

The dietary exposure database is adequate to support the registration review of the 

cypermethrins. However, if the acute and chronic dietary endpoints change, an updated dietary 

risk assessment may be needed; in addition, anticipated residues have been used in previous risk 

assessments, and may need to be updated. Any updated dietary assessment would include more 

current percent crop treated estimates, new residue monitoring data, and if needed, updated 

drinking water estimates. Currently, there are no dietary risk estimates of concern for the 

existing uses of the cypermethrins. During registration review, the tolerance expressions for 

both cypermethrin and zeta-cypermethrin should be revised to conform with current standards. 

The residential exposure database is adequate to support registration review for cypermethrin and 

zeta-cypermethrin. All of the residential handler and postapplication risk estimates are below the 

Agency’s level of concern. An updated residential exposure assessment may be needed during 

registration review as a result of the revisions to HED’s Residential Exposure Standard 

Operating Procedures (SOPs). Furthermore, because of the potential for residential bystander 

exposures due to cypermethrin and zeta-cypermethrin from aerial and airblast applications, 

volatilization, and/or transport from treated areas, HED will evaluate the need for a bystander 

assessment during registration review.

For the cypermethrins, residential exposures are aggregated with dietary exposures. In the most 

recent human health risk assessments, there were no aggregate risk estimates of concern (Memo, 

D344749, D. McNeilly et al., 11/27/2007; Memo, D293416, J. Doherty et al., 4/06/2006). 

During registration review, updated aggregate risk assessments may be needed; however, HED 

expects to update aggregate risk estimates in conjunction with new uses currently under review. 

The cypermethrins were included in HED’s recent cumulative risk assessment for synthetic 

pyrethroids (USEPA, 2011). 

The occupational exposure database is adequate to support registration review for cypermethrin 

and zeta-cypermethrin. There are no occupational handler and postapplication risk estimates of 

concern. HED will consider the need for an updated occupational exposure assessment during

registration review.

Introduction

HED evaluated the most recent human health risk assessments for cypermethrin and zetacypermethrin in association with the updates to their toxicity, exposure, and usage databases to 

determine if sufficient data are available and if further updates are needed to support registration 

review. Recent human health risk assessments include a 2007 assessment for the use of zeta-
4

cypermethrin on citrus, oilseeds, safflower, wild rice and okra (Memo, D344749, D. McNeilly et 

al., 11/27/2007) and the 2006 Phase 4 HED Risk Assessment for the re-registration of 

cypermethrin (Memo, D293416, J. Doherty et al., 4/06/2006). In addition, HED considered the 

latest Agency science policies and risk assessment methodologies. The structure of the 

cypermethrins, as well as their chemical names and other identifiers can be found in the chemical 

identity table attached to this document (Attachment 1).

Cypermethrin is registered for foliar applications to control a wide range of pests on agricultural 

food/feed crops using ground, sprinkler irrigation, or aerial equipment. Cypermethrin is also 

registered as a soil residual termiticide, for outdoor pest control to structures and lawns, indoor 

pest control (dilutable formulations for crack & crevice or spot treatments, total release foggers 

or aerial space sprays), livestock ear tags, and for application to horses. It can be used in 

industrial, commercial, and residential sites. The single active ingredient formulations of 

cypermethrin include the emulsifiable concentrate (EC), the soluble concentrate/liquid (SC/L), 

the granular (G), and the wettable powder (WP). 

Cypermethrin is a mixture of 8 stereoisomers. The mixture contains four sets of enantiomers, 

each containing an isomer with either an “S” or “R” configuration at the cyano bearing carbon. 

Zeta-cypermethrin is an enrichment of the more insecticidally potent S-isomers; 24% each of the 

“S” isomers and 1% each of the insecticidally less active “R” isomers. Zeta-cypermethrin has 

been registered on the same agricultural crops as cypermethrin plus many more. Due to its 

greater insecticidal potency, zeta-cypermethrin application rates are less than those for

cypermethrin. 

Tolerances for residues of cypermethrin are listed under 40 CFR §180.418(a)(1), and include all 

eight stereoisomers. Tolerances for residues of zeta-cypermethrin are listed under 40 CFR 

§180.418(a)(2), and are expressed in terms of zeta-cypermethrin and its inactive R-isomers. 

These tolerances are summarized in Appendix 5. Tolerances have been established for residues 

in crops as well as in livestock commodities. These tolerances range in value from 0.05 to 40 

ppm, with most of these tolerances being 15.0 ppm or less. The tolerances are identical for all

commodities where both cypermethrin and zeta-cypermethrin are registered, which includes all 

livestock commodities; brassica; head lettuce; onion; and pecan.

During registration review, the tolerance expressions should be revised so that they conform to 

current standards with respect to coverage and compliance. The tolerance enforcement methods 

for plant and animal commodities do not distinguish between cypermethrin and zetacypermethrin, even though they have separate tolerance listings in the CFR.

Hazard Identification/Toxicology

As with the other pyrethroids, the cypermethrins cause neurotoxicity in insects and mammals by 

the modulation of nerve axon sodium channels. Pyrethroids interfere with the ability of the 

nervous system to relay nerve transmissions, and in mammals, can cause tremors, convulsions, 

salivation, and other clinical effects. 
5

As previously described, zeta-cypermethrin is an enrichment of the more insecticidally potent 

isomers of cypermethrin. However, the mammalian toxicity of cypermethrin and zetacypermethrin are similar and therefore the databases of guideline toxicology studies for 

cypermethrin and zeta-cypermethrin were combined in the most recent zeta-cypermethrin risk 

assessment (D344749, 11/27/07). 

The scientific quality of the submitted studies is high, and the toxicity profile is sufficient for 

characterization of potential carcinogenic, mutagenic, developmental, and reproductive effects. 

Since the most recent risk assessment, an immunotoxicity study has become available for hazard 

consideration and is currently under review.

Acute toxicity studies conducted with Zeta/ cypermethrin indicate that it is moderately acutely 

toxic via the oral route (Category II); however, it is not very toxic via the dermal or inhalation 

routes (Categories III and IV, respectively). It is mildly irritating to the eyes and skin and is not 

a dermal sensitizer.

In the subchronic and chronic oral studies, neurotoxic effects including tremors, gait 

abnormalities, ataxia and hypersensitivity were regularly observed at the study LOAELs. This 

class of compounds is known to induce clinical signs of neurotoxicity in mammals. For 

example, gait abnormalities, tremors, reduced motor activity, and convulsions are typically 

observed across species, sexes, and routes of administration. In addition, pyrethroids are quickly 

absorbed and metabolized in vivo, preventing increased toxicity with repeated dosing. Dermal 

application of cypermethrin did not result in systemic toxicity in rats and rabbits. The low rate of 

dermal penetration, combined with rapid metabolism and clearance, generally preclude toxicity 

of pyrethroids via the dermal route. Conversely, a 21-day inhalation study for cypermethrin 

resulted in lower NOAELs compared to the oral studies. As a result, increased duration of 

dosing with cypermethrin did not result in greater potency. In fact, indications of chronic 

toxicity were limited to decreased body weight and lung tumors. These effects were only 

observed in the 2-year carcinogenicity study in the mouse and occurred at significantly higher 

doses than the acute effects previously discussed.

Studies on the cypermethrins showed no evidence of developmental or reproductive toxicity. In 

the prenatal developmental toxicity studies in rats and rabbits, there was no evidence of 

developmental toxicity up to the highest dose tested, including doses at which maternal toxicity 

typical of pyrethroid was observed. In the multi-generation reproduction studies in rats, 

offspring toxicity was observed at the same treatment level that resulted in parental systemic 

toxicity. There did not appear to be any increases in severity of toxicity for the pups in these 

studies. In the developmental neurotoxicity (DNT) study, there were no maternal effects at the 

highest dose tested. However, an offspring NOAEL and LOAEL were established based on 

reduced body weight and body weight gain in female pups.

Despite the limited susceptibility seen in the DNT, HED previously reduced the FQPA Safety 

Factor to 1X based on the weight of the evidence and the overall completeness of the database. 

However, the Agency has since determined that there is a potential for susceptibility of offspring 

to all pyrethroids based on evidence of age-dependent toxicity seen in literature studies 

(D381210, 6/27/11). The young appear to be more susceptible based on decreased metabolic 
6

capacity to detoxify pyrethroids, and for the purpose of the pyrethroid cumulative risk 

assessment, HED retained a 3X FQPA Safety Factor for children, and supported reduction to 1X 

for adults. For new use assessments and during registration review, this approach will have an 

impact on the FQPA SF for the cypermethrins.

HED’s Cancer Peer Review Committee (CPRC) classified cypermethrin as a Group C “Possible 

human carcinogen”, based on an increased incidence of lung adenomas and adenomas plus 

carcinomas combined in female mice (CPRC, 1988). The presence of common benign tumors in 

one species and one sex, with no increase in the proportion of malignant tumors or decrease in 

the time-to-tumor occurrence, together with the lack of mutagenic activity, was not considered 

strong enough to warrant a quantitative approach to assessing human cancer risk. Consequently, 

the CPRC concluded that the chronic dietary assessment would be protective of potential cancer 

risk. This approach may need to be reconsidered in conjunction with new uses and during 

registration review.

In the most recent human health risk assessment for the cypermethrins, points-of-departure 

(PODs) for oral and inhalation exposure are based on both neurotoxic and systemic endpoints. 

Dermal risks were only assessed for children, by extrapolation from an oral study. The 

inhalation risk assessment was based on a route-specific inhalation toxicity study in which 

salivation and decreased body weight were observed.

Conclusions for Hazard Identification/Toxicology

Cypermethrin technical is a mixture of eight isomers; zeta-cypermethrin is an enrichment of four 

more efficacious isomers, and is more insecticidally potent. However, based on similar 

mammalian toxicity profiles, the toxicity databases are combined for purposes of risk 

assessment. The toxicology database for the cypermethrins is complete, and no additional data 

are being required during registration review. Following the completion of the screening level 

pyrethroid cumulative risk assessment, HED is in the process of updating endpoint selection for 

single chemical risk assessments for all pyrethroids. For the cypermethrins, evaluation of new 

uses may require HED to revise endpoints and doses selected for risk assessment prior to the 

completion of registration review.

Dietary Exposure

As stated above, both cypermethrin and zeta-cypermethrin are registered for use on a wide 

variety of crops. Tolerances have also been established for residues in milk and eggs as well as 

in the fat, meat of cattle, goats, hogs, horses, sheep, and poultry, and meat byproducts of cattle, 

goats, horses, and sheep. Nearly all of the tolerances for cypermethrin and zeta-cypermethrin are 

15.0 ppm or less. The only exceptions are zeta-cypermethrin tolerances of 35 ppm for grass, 

forage, fodder and hay, group 17, hay and 40 ppm for animal feed, nongrass, group 18, hay. 

HED used the Dietary Exposure Evaluation Model (DEEM-FCIDTM Version 2.03) to conduct the 

most recent acute and chronic aggregate dietary (food and drinking water) risk assessments for 

the cypermethrins. This model incorporates consumption data from the USDA’s Continuing 

Survey of Food Intakes by Individuals taken between 1994 and 1996 along with a supplemental 
7

children’s survey taken in 1998. The acute dietary risk assessment was unrefined, i.e., tolerancelevel residues and 100% crop treated were assumed for all commodities. The chronic dietary 

risk assessment was refined, with residue inputs based on field trial data, Pesticide Data Program 

(PDP) monitoring data, and percent crop treated estimates from BEAD. The chronic dietary 

exposure has been refined to this extent because the chronic dietary exposure represents 

background exposure from food and water for aggregate risk assessment.

The acute and chronic analyses were also based on anticipated residues (ARs) in animal 

commodities and both empirical and default processing factors. The chronic dietary risk 

assessment is considered protective of cancer effects.

The last dietary exposure analysis included both cypermethrin and zeta-cypermethrin. The acute 

dietary exposure resulted in an estimated risk equivalent to 30% of the aPAD (acute population 

adjusted dose) for the general U.S. population at the 95th percentile of exposure. The most 

highly exposed population subgroup was Children 1-2 years old, which used 54% of the aPAD at 

the 95th percentile of exposure. Even with an additional 3X FQPA Safety Factor, HED does not 

expect acute dietary risk concerns. Chronic dietary exposure to the cypermethrins resulted in an 

estimated risk equivalent to 1% of the cPAD (chronic population adjusted dose) for the general 

U.S. population. The most highly exposed population subgroup was Children 1-2, which used 

3% of the cPAD. 

EFED recommended that modeled estimates of residues in drinking water be used in the most 

recent dietary risk assessment. During registration review, HED will evaluate whether updated 

drinking water estimates are available and whether these revised estimates make it necessary to 

complete a new dietary assessment. Depending on the magnitude of any updates, a new dietary 

assessment may be required to appropriately estimate risks associated with drinking water 

exposure. .

Conclusions for Dietary Exposure

The dietary exposure database is adequate to support the existing registrations and tolerances. 

No new residue chemistry data are required. A number of new uses are currently under review 

for zeta-cypermethrin, and consequently a new dietary assessment, including food and drinking 

water, will be needed in support of those registration actions. Therefore, the dietary assessments 

associated with these ongoing registration actions may make completing a new dietary 

assessment during registration review unnecessary. However, a new dietary assessment may be 

needed if one or more of the following occur: new data are identified which impact dietary 

exposure estimates, including those from drinking water; new toxicological points of departure 

are identified, including revisions to the FQPA SF; OPP dietary exposure policies and 

procedures are revised. HED is in the process of updating its dietary model to incorporate more 

recent consumption data from the National Health and Nutrition Examination Survey 

(NHANES). This new version of the model will be used during registration review if a new 

dietary assessment is needed. 
8

Residential Exposure and Risk

Cypermethrin and zeta-cypermethrin are registered for use in a variety of indoor and outdoor 

residential environments including: lawns, gardens, indoor surfaces and spaces, and on pets. 

Due to this use profile, adult residential homeowners may experience dermal and inhalation 

exposure to cypermethrin and zeta-cypermethrin during application of the chemical (i.e., 

residential handler exposures). Adults and children may experience dermal, inhalation, and 

incidental oral (children only) exposure to both active ingredients from contacting treated areas 

(i.e., residential postapplication exposure).

There are a variety of cypermethrin products currently registered for use by homeowners in 

residential settings. For adults, there is no hazard associated with dermal exposure to the 

cypermethrins, and consequently there are no dermal risks for adults. Residential inhalation risk

estimates are below HED’s level of concern (i.e., MOE > 100) for all residential handler 

scenarios. Residential handler intermediate- or long-term exposures to cypermethrin or zetacypermethrin are not anticipated. Therefore, no intermediate- or long-term dermal or inhalation 

exposures or risks have been assessed.

Residential Handlers

Residential postapplication exposure to the cypermethrins can occur when adults or children reenter treated areas such as indoor surfaces and lawns, or come into contact with treated pets. No

postapplication risks were identified for adults exposed via the dermal route, due to the lack of 

toxicity. For children, no risk estimates of concern were identified for postapplication exposure 

via dermal and oral (i.e., hand-to-mouth) routes.

Residential Postapplication 

Previously, HED used default assumptions from the Residential Standard Operating Procedures 

(SOP), April 5, 2000 to assess residential handler and postapplication exposure. However, as a 

result of the revisions to these SOPs, the parameters and algorithms for dermal and hand-tomouth exposure calculations are changing. For the indoor scenarios HED will use default 

assumptions from the Residential SOPs (2012). For the turf use, a Transferable Turf Residue 

(TTR) study is available for cypermethrin; a liquid formulation was assessed in the study, even 

though the registered formulation used on turf is a granular. Although the TTR study was not 

conducted using a granular formulation, the study is considered adequate for the following 

reasons: 1) granulars are typically about an order of magnitude lower than the liquids in terms of 

transferability, so use of the study will not underestimate exposure to the granular formulation; 

and 2) when a pesticide is available in several different formulations, a liquid formulation (e.g., 

emulsifiable concentrate) should be chosen for testing. Therefore, HED is not requesting a new 

TTR study with the granular formulation. During registration review, HED will review the TTR 

study so that it can be used quantitatively in risk assessment. In addition, HED may conduct a 

new residential exposure assessment that incorporates new methods or policies for estimating 

exposure associated with residential use patterns. This update might occur prior to registration 

review, in conjunction with the evaluation of new uses. 

Based on the Agency’s current practices, a quantitative postapplication inhalation exposure 

assessment has not been performed for the cypermethrins, primarily because of their low vapor 
9

pressures. However, volatilization of pesticides may be a potential source of postapplication 

inhalation exposure to individuals nearby pesticide applications. The Agency sought expert 

advice and input on issues related to volatilization of pesticides from its Federal Insecticide, 

Fungicide, and Rodenticide Act Scientific Advisory Panel (SAP) in December 2009. The 

Agency received the SAP’s final report on March 2, 2010 

(http://www.epa.gov/scipoly/SAP/meetings/2009/120109meeting.html). The Agency is in the 

process of evaluating the SAP report and may, as appropriate, develop policies and procedures to 

identify the need for and, subsequently, the way to incorporate postapplication inhalation 

exposure into the Agency's risk assessments. If new policies or procedures are put into place, the 

Agency may revisit the need for a quantitative postapplication inhalation exposure assessment.

Residential bystander exposures might also occur as a result of cypermethrin and zetacypermethrin aerial and airblast applications and/or transport from treated areas. Spray drift is 

always a potential source of exposure to residents nearby to spraying operations. This is 

particularly the case with aerial application, but, to a lesser extent, could also be a potential 

source of exposure from ground–based applications of cypermethrin and zeta-cypermethrin. The 

Agency has been working with the Spray Drift Task Force, EPA Regional Offices and State 

Lead Agencies for pesticide regulation and other parties to develop the best spray drift 

management practices (see the Agency’s Spray Drift website for more information at 

http://www.epa.gov/opp00001/factsheets/spraydrift.htm). Other potential sources of residential 

exposure include volatilization of pesticides and re-suspension of dusts and/or particulates that 

contain pesticides. 

Although a quantitative residential postapplication inhalation exposure assessment was not 

performed as a result of pesticide drift from neighboring treated agricultural fields, an inhalation 

exposure assessment was performed for flaggers, and is considered representative of a worst case 

for inhalation (drift) exposure.

Recent occupational and residential exposure assessments evaluated exposure to children 

resulting from the use of insect control products containing zeta-cypermethrin in homes (S. 

Wang, D337823, 3/30/2007 and S. Wang D344353, 9/20/2007). In the most recent human 

health risk assessment, the total dermal and oral exposure and risk estimates for children from 

the use of zeta-cypermethrin products on lawns and inside homes resulted in risks that were not 

of concern (D. McNeilly, D344749, 11/27/2007).

Combined Residential Exposure and Risk

Conclusions for Residential Exposure and Risk Assessment

The residential exposure database is adequate to support the registration review process for 

cypermethrin and zeta-cypermethrin. No new chemical-specific exposure data are being 

requested in conjunction with registration review. An updated residential exposure assessment 

may be required under registration review as a result of the revisions to HED’s Residential 

Exposure SOPs. An updated assessment may also be required if new data are identified which 

impact exposure estimates, or if there are new points of departure, a revised FQPA SF, or 

revisions to exposure policies and procedures. However, as noted above, many of these changes 

may be incorporated into new use risk assessments prior to the completion of registration review.
10

Aggregate Risk Assessment

In the most recent risk assessment (Memo, D344749, D. McNeilly, 11/27/2007), aggregate risk 

assessments for combined zeta-cypermethrin and cypermethrin exposures were conducted as 

follows: acute and chronic aggregate assessments were conducted based on food and water 

exposures, and short-term aggregate assessments were conducted based on food, water, and 

residential exposures. The latter were based on cypermethrin residential uses because its 

application rate is higher than that of zeta-cypermethrin. No long-term aggregate risk assessment

was conducted because no long-term exposure scenarios are expected from residential uses of 

cypermethrin and zeta-cypermethrin. There were no aggregate risk estimates of concern

associated with the existing uses.

Conclusions for Aggregate Assessment

During registration review, updated aggregate assessments may be conducted to include changes 

in toxicological endpoints, updated dietary exposure estimates, and updated residential exposure 

estimates. However, these updates may occur in conjunction with new use risk assessments, and 

therefore would not be needed during registration review.

Occupational Exposure and Risk

Occupational exposures to the cypermethrins result from uses on agricultural crops and animals, 

commercial lawns, and in and around industrial and commercial premises. Cypermethrin 

formulations include: liquid concentrates, granular, wettable powders, and ready-to-use products, 

foggers, trigger-pump sprayers, impregnated wipes, and ear tags. Zeta-cypermethrin 

formulations include: liquid concentrates, granular and ready-to-use products. Applications to 

agricultural crops can be made with aerial, ground and handheld equipment. Applications at 

industrial and commercial sites can be made using handheld equipment. Occupational handler 

exposures have been evaluated for all cypermethrin and zeta-cypermethrin registered uses.

Occupational and residential handler exposure was assessed using surrogate data from the 

Pesticide Handlers Exposure Database (PHED ver. 1.1) and data from the Outdoor Residential 

Exposure Task Force (ORETF). For occupational handlers, short- and intermediate-term 

inhalation risk estimates are below the Agency’s level of concern at some level of risk mitigation 

(e.g., dust mist respirator or water-soluble packaging).

Occupational Handlers

Several occupational handler exposure scenarios were considered long-term, including 

applications to residential, commercial, and industrial turf by commercial lawn care operators 

and applications by pest control operators. Since the toxicological endpoints of concern for 

long-term exposures are based on similar adverse effects, long-term dermal and inhalation risk 

estimates were combined for occupational scenarios where long-term exposures are anticipated. 

No long-term risk estimates for occupational handlers were identified. Based on new policies

and procedures, during registration review, HED will re-consider whether the previously 
11

identified and assessed long-term exposure scenarios are still considered to be long-term in 

duration. 

Recently, PHED has been updated by the Occupational Pesticide Handler Unit Exposure 

Surrogate Reference Table (September, 2011). In order to determine if new assessments would 

be needed during registration review, HED conducted a cursory review of the revised inhalation 

handler unit exposures, and compared these to the previous unit exposures used to assess handler 

risks. Although there do not appear to be any risk estimates of concern for registered uses based 

on the new unit exposures, HED may conduct updated handler exposure and risk assessments 

during registration review. 

Occupational Postapplication

Postapplication risk estimates for agricultural workers contacting treated crops were not 

quantitatively assessed, since no short- or intermediate-term dermal endpoints of concern were 

identified, and since long-term dermal exposures are not expected for tasks involving any of the 

registered crop use patterns. A restricted-entry interval (REI) of 12 hours is considered adequate 

based on the acute toxicity profiles of the cypermethrin and zeta-cypermethrin technical 

materials.

Based on the Agency's current practices, a quantitative postapplication inhalation exposure 

assessment was not performed for cypermethrin and/or zeta-cypermethrin. However, there are 

multiple potential sources of inhalation exposure to individuals performing postapplication 

activities in previously treated fields. These potential sources include volatilization of pesticides 

and re-suspension of dusts and/or particulates that contain pesticides. The Agency sought expert 

advice and input on issues related to volatilization of pesticides from its Federal Insecticide, 

Fungicide, and Rodenticide Act Scientific Advisory Panel (SAP) in December 2009, and 

received the SAP’s final report on March 2, 2010 

(http://www.epa.gov/scipoly/SAP/meetings/2009/120109meeting.html). The Agency is in the 

process of evaluating the SAP report as well as available postapplication inhalation exposure 

data generated by the Agricultural Reentry Task Force and may, as appropriate, develop policies 

and procedures, to identify the need for and, subsequently, the way to incorporate occupational 

postapplication inhalation exposure into the Agency's risk assessments. If new policies or 

procedures are put into place, the Agency may revisit the need for a quantitative occupational 

postapplication inhalation exposure assessment for cypermethrin and zeta-cypermethrin.

Although a quantitative postapplication inhalation exposure assessment was not performed, an 

inhalation exposure assessment was performed for occupational/commercial handlers. Handler 

exposure resulting from application of pesticides outdoors is likely to result in higher exposure 

than postapplication exposure. Therefore, since there were no risk estimates of concern 

identified for handlers, inhalation postapplication exposure is not expected to result in risk 

estimates of concern.
12

Conclusions for Occupational Exposure and Risk Assessment

The occupational exposure database is adequate to support the registration review process for 

cypermethrin and zeta-cypermethrin. Updated occupational handler exposure assessments may 

be needed during registration review based upon revisions to the Agency’s scenario-specific 

surrogate handler exposure data (http://www.epa.gov/pesticides/science/handler-exposuretable.pdf). Updated occupational postapplication exposure assessments may also be needed

based on updated dermal transfer coefficients [Science Advisory Council for Exposure Policy 

Number 3 (http://www.epa.gov/pesticides/science/exposac_policy3.pdf)]. Revised occupational 

handler and postapplication assessments may also be needed if toxicological endpoints change or 

other new data are received by the Agency which impact exposure estimates. However, these 

updates may be included in new uses risk assessments, prior to the completion of registration 

review.

Public Health and Pesticide Epidemiology Data

D396106, S. Recore, Jan. 3, 2012

For this evaluation, the OPP Incident Data System (IDS) was utilized to retrieve pesticide 

incident data on the active ingredients cypermethrin (PC Code 109702) and zeta-cypermethrin 

(PC Code 129064). Main IDS incidents involving only one pesticide are considered to provide 

more certain information about the potential effects of exposure from the pesticide. When an 

incident involves more than one pesticide, it is difficult to determine which effects are attributed 

to the pesticide being considered. However, because cypermethrin is often co-formulated with 

other active ingredients, it is important to consider the incidents involving multiple chemicals in 

this case. The less severe human incidents (minor, unknown, or no effects outcomes) are 

reported by registrants as counts called aggregate summaries and are recorded in a separate 

module called Aggregate IDS.

Cypermethrin 

From January 1, 2006 to November 2, 2011, in the Main IDS there were 280 incidents reported 

for cypermthrin only, with 278 of these exposure being classified as major or moderate (20 

major, 258 moderate). In addition, 304 cypermethrin exposures that involved more than one 

chemical were also reported to Main IDS. Over the same time period, 4,285 exposures were 

reported to Aggregate IDS involving cypermethrin, resulting in low severity outcomes (67 

exposures classified as an unknown/no effects outcome, 4,218 classified as a minor outcome). 

 

The majority of health effects associated with these incidents involved dermal, neurological, 

gastrointestinal, and respiratory symptoms. Most of the cases occurred at home in a residential 

setting, although there were cases that occurred in occupational settings as well. Patients 

reported inhaling the product, or accidentally getting the product on their faces, hands, arms, 

and/or legs. These exposures occurred while the patients were applying or using the product 

either indoors or outdoors. Many incidents appeared to occur because the product was used 

improperly. That is, the applicator failed to follow the label directions, overused a product, or 

did not use personal protective equipment (e.g. gloves, masks, and/or protective clothing). In 
13

some cases, exposures occurred because the applicator came in direct contact with cypermethrin 

after a leak or spill. Exposures also occurred after application. Although most of these incidents 

were of low severity, the overall high frequency of exposure to cypermethrin has the potential to 

result in high severity outcomes. Consequently, these incident data warrant further analysis in 

the preliminary risk assessment phase of Registration Review.

Zeta-cypermethrin

Overall, there are few incidents involving zeta-cypermethrin reported and most are classified as 

moderate or low severity. Therefore, for zeta-cypermethrin, based on the low frequency and 

severity of incident cases, there does not appear to be a concern at this time that would warrant 

further investigation. The Agency will continue to monitor the incident information and if a 

concern is triggered, additional analysis will be included in the risk assessment.

Tolerance Assessment and International Harmonization

The nature of the residue in animals is adequately understood (D269584; Y. Donovan; Nov 3, 

2000). HED previously concluded that, for the case of cypermethrin and zeta-cypermethrin, the 

parent compound is the only residue of concern which needs to be included in the tolerance 

expression and used for dietary risk assessment, including drinking water. Tolerances for 

residues of cypermethrin are listed under 40 CFR §180.418(a)(1), which includes all eight 

stereoisomers. Tolerances for residues of zeta-cypermethrin are listed under 40 CFR 

§180.418(a)(2), and are expressed in terms of zeta-cypermethrin and its inactive R-isomers. The 

inclusion of the inactive R-isomers in the tolerance expression is appropriate because the

enforcement methods listed in PAM Volume II are not stereospecific; thus no distinction is made 

between residues of cypermethrin (all eight stereoisomers) and zeta-cypermethrin (an enriched 

isomer form of cypermethrin). 

During registration review, the tolerance expressions should be revised so they address both 

coverage and measurement:

• The tolerance expression for cypermethrin should be revised as follows:

“Tolerances are established for residues of cypermethrin, including its metabolites and 

degradates, in or on the commodities in the table below. Compliance with the 

tolerance levels specified below is to be determined by measuring only cypermethrin.”

• The tolerance expression for zeta-cypermethrin should be revised as follows:

“Tolerances are established for residues of zeta-cypermethrin, including its metabolites 

and degradates, in or on the commodities in the table below. Compliance with the 

tolerance levels specified below is to be determined by measuring only zetacypermethrin.” 

Codex has established maximum residue limits (MRLs) for cypermethrin, defined as 

“cypermethrin (sum of all isomers).”

For both cypermethrin and zeta-cypermethrin, Mexico adopts U.S. tolerances and/or Codex 

MRLs for its export purposes. Canada has established MRLs for cypermethrin only. It has not 
14

established MRLs for zeta-cypermethrin per se. In most cases, the Codex and Canadian MRLs 

differ from each other as well as from the U.S. tolerance.

The international residue limit status sheet can be found in Attachment 4. 

During registration review, HED will reconsider the U.S. tolerances and will harmonize them 

with Codex MRLs to the extent possible.

Environmental Justice

Potential areas of environmental justice concerns, to the extent possible, were considered in this 

human health risk assessment, in accordance with U.S. Executive Order 12898, "Federal Actions 

to Address Environmental Justice in Minority Populations and Low-Income Populations," 

(http://www.eh.doe.gov/oepa/guidance/justice/eo12898.pdf. As a part of every pesticide risk 

assessment, OPP considers a large variety of consumer subgroups according to well-established 

procedures. In line with OPP policy, HED estimates risks to population subgroups from 

pesticide exposures that are based on patterns of that subgroup’s food and water consumption, 

and activities in and around the home that involve pesticide use in a residential setting. 

Extensive data on food consumption patterns are compiled by the USDA under the Continuing 

Survey of Food Intake by Individuals (CSFII) and are used in pesticide risk assessments for all 

registered food uses of a pesticide. These data are analyzed and categorized by subgroups based 

on age, season of the year, ethnic group, and region of the country. Additionally, OPP is able to 

assess dietary exposure to smaller, specialized subgroups and exposure assessments are 

performed when conditions or circumstances warrant. Whenever appropriate, non-dietary 

exposures and risks based on home use of pesticide products for adult applicators and

postapplication activities for toddlers, youths, and adults entering or playing on treated areas are 

evaluated. Further considerations are currently in development as OPP has committed resources 

and expertise to the development of specialized software and models that consider exposure to 

bystanders and farm workers as well as lifestyle and traditional dietary patterns among specific 

subgroups.

Endocrine Disruptor Screening Program 

As required by FIFRA and FFDCA, EPA reviews numerous studies to assess potential adverse 

outcomes from exposure to chemicals. Collectively, these studies include acute, subchronic and 

chronic toxicity, including assessments of carcinogenicity, neurotoxicity, developmental, 

reproductive, and general or systemic toxicity. These studies include endpoints which may be 

susceptible to endocrine influence, including effects on endocrine target organ histopathology, 

organ weights, estrus cyclicity, sexual maturation, fertility, pregnancy rates, reproductive loss, 

and sex ratios in offspring. For ecological hazard assessments, EPA evaluates acute tests and 

chronic studies that assess growth, developmental and reproductive effects in different 

taxonomic groups. As part of the most recent registration decision in 2006, EPA reviewed these 

data and selected the most sensitive endpoints for relevant risk assessment scenarios from the 

existing hazard database. However, as required by FFDCA section 408(p), cypermethrin is 

subject to the endocrine screening part of the Endocrine Disruptor Screening Program (EDSP). 
15

EPA has developed the EDSP to determine whether certain substances (including pesticide 

active and other ingredients) may have an effect in humans or wildlife similar to an effect 

produced by a “naturally occurring estrogen, or other such endocrine effects as the Administrator 

may designate.” The EDSP employs a two-tiered approach to making the statutorily required 

determinations. Tier 1 consists of a battery of 11 screening assays to identify the potential of a 

chemical substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal 

systems. Chemicals that go through Tier 1 screening and are found to have the potential to 

interact with E, A, or T hormonal systems will proceed to the next stage of the EDSP where EPA 

will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2 

testing is designed to identify any adverse endocrine-related effects caused by the substance, and 

establish a dose-response relationship between the dose and the E, A, or T effect. 

Under FFDCA section 408(p), the Agency must screen all pesticide chemicals. Between October 

2009 and February 2010, EPA issued test orders/data call-ins for the first group of 67 chemicals, 

which contains 58 pesticide active ingredients and 9 inert ingredients. Cypermethrin was 

included on that list and has been issued an order to conduct the Tier 1 testing. Once all required 

Tier 1 and Tier 2 data have been received and reviewed, the endpoints and safety factors used for 

risk assessment purposes will be examined and a new risk assessment performed if necessary. 

For further information on the status of the EDSP, the policies and procedures, the list of 67 

chemicals, future lists, the test guidelines and the Tier 1 screening battery, please visit our 

website: http://www.epa.gov/endo/. 

Cumulative Risk Assessments 

The Food Quality Protection Act (FQPA) requires the Agency to consider the cumulative risks of 

chemicals sharing a common mechanism of toxicity. The cypermethrins are included in the 

pyrethroid/pyrethrin common mechanism group (http://www.regulations.gov; EPA-HQ-OPP2008-0489-0006). The members of this group share the ability to interact with voltage-gated 

sodium channels ultimately leading to neurotoxicity. The cumulative risk assessment for the 

pyrethroids/pyrethrins was published on Nov. 9, 2011 and is available 

at http://www.regulations.gov; EPA-HQ-OPP-2011-0746. No cumulative risks of concern were 

identified allowing the Agency to consider new uses for pyrethroid actives. For information 

regarding EPA’s efforts to evaluate the risk of exposure to pyrethroids, refer 

to http://www.epa.gov/oppsrrd1/reevaluation/pyrethroids-pyrethrins.html. 

Human Studies

Past cypermethrins risk assessments rely in part on data from studies in which adult human 

subjects were intentionally exposed to a pesticide to determine their dermal and inhalation 

exposure. These data, which include studies from the Pesticide Handlers Exposure Database 

Version 1.1 (PHED 1.1); the Outdoor Residential Exposure Task Force (ORETF) database; the 

Agricultural Re-entry Task Force (ARTF) database; and other registrant-submitted exposure 

monitoring studies, are subject to ethics review pursuant to 40 CFR 26, have received that 

review, and are compliant with applicable ethics requirements. For certain studies that review 

may have included review by the Human Studies Review Board. Descriptions of data sources as 
16

well as guidance on their use can be found at http://www.epa.gov/pesticides/science/handlerexposure-data.html and http://www.epa.gov/pesticides/science/post-app-exposure-data.html.

Data Requirements

No new data requirements (for human health risk assessment) have been identified for the 

cypermethrins to support registration review.

References

Cypermethrin and Zeta-Cypermethrin – Conclusions of the Meeting of Metabolism Assessment 

Review Committee D269584; Y. Donovan; Nov 3, 2000. 

Cypermethrin: Phase 4 HED Risk Assessment for the Reregistration Eligibility Decision (RED). 

PC Code 109702; DP Barcode D293416. April 6, 2006. 

Zeta-Cypermethrin: Addendum to “Occupational and Residential Risk Assessment to Support 

Request for a Section 3 Registration of New Use of Zeta-Cypermethrin” D337823. March 30, 

2007.

Zeta-cypermethrin/cypermethrin. Acute and Chronic Dietary (Food and Drinking Water) 

Exposure and Risk Assessments for Section 3 Use of Zeta-cypermethrin on Citrus (Crop Group 

10), Oilseed Commodities (except cottonseed), Okra, Safflower, and Wild Rice. PC Codes: 

109702 & 129064. PP#s: 6F7132, 6E7133, and 6F7057. Decision No.: D371717. DP Barcode: 

D335224. Dennis McNeilly, Nov 5, 2007.

Zeta-cypermethrin: Human Health Risk Assessment for Section 3 Use of Zeta-cypermethrin on 

Citrus (Crop Group 10), Oilseeds (proposed Crop Group 20, except cottonseed), Safflower, Wild 

Rice and Okra. PC Code: 129064. DP Number: D344749. Dennis McNeilly, Nov. 27, 2007. 

USEPA (2011). "Pyrethroid Cumulative Risk Assessment, D394567, 10/04/11." Available at: 

http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2011-0746-0003

Cypermethrin and Zeta-Cypermethrin: Review of Human Incidents. Shanna Recore. D396106. 

January 3, 2012. 

Attachments

Attachment 1. Chemical Identity Table

Attachment 2. Cypermethrin and Zeta-Cypermethrin Endpoint Selection Tables

Attachment 3. Cypermethrin and Zeta-Cypermethrin Products and Use Sites

Attachment 4. International Residue Limit Status
17

Attachment 1. Chemical Identity Table

Chemical Identity

Common Name Cypermethrin and Zeta-Cypermethrin

CAS Name Cypermethrin: 

(±)-alpha-3-cyano-(3-phenoxyphenyl)methyl [(±)-cis, trans-3(2,2-dichloroethenyl)-

2,2-dimethylcyclopropanecarboxylate

Zeta-Cypermethrin: 

(S)-cyano(3-phenoxyphenyl)methyl (±)-cis-trans-3-(2,2-dichloroethenyl)-2,2-

dimethylcyclopropanecarboxylate

IUPAC Name Cypermethrin: 

(RS)-α-cyano-3-phenoxybenzyl (1RS,3RS,1RS,3SR)-3-(2,2-dichlorovinyl)-2,2-

dimethylcyclopropanecarboxylate

or

(RS)-α-cyano-3-phenoxybenzyl (1RS)-cis-trans-3-(2,2-dichlorovinyl)-2,2-

dimethylcyclopropanecarboxylate

Zeta-Cypermethrin: 

(S)-α-cyano-3-phenoxybenzyl (1R)-cis-trans-3-(2,2-dichlorovinyl)-2,2-

dimethylcyclopropanecarboxylate

or

(S)-α-cyano-3-phenoxybenzyl (1RS, 3RS, 1SR, 3SR)-3-(2,2-dichlorovinyl)-2,2-

dimethylcyclopropanecarboxylate

PC Codes Cypermethrin: 109702

Zeta-Cpermethrin: 120964

Chemical Abstracts Numbers Cypermethrin: 52315-07-8

Zeta-Cypermethrin: 97955-44-7

Registration Review Case No. 2130

Chemical Class Pyrethroid Insecticide

Vapor Pressure 1.9 x 10-9 mm Hg at 25°C

Chemical Structure

Cl

Cl O

O O

H

N
18

Attachment 2. Cypermethrins Endpoint Selection Table

Summary of Toxicological Doses and Endpoints for Zeta-cypermethrin/cypermethrin for Use in Human 

Risk Assessments (Studies are conducted with cypermethrin unless specified otherwise).

Exposure/

Scenario

Dose Used in Risk 

Assessment, UF 

FQPA SF and Level 

of Concern for Risk 

Assessment

Study and Toxicological Effects

Acute Dietary

(General 

population 

including infants 

and children)

NOAEL = 10.0 

mg/kg/day

UF = 100

Acute RfD = 0.1 

mg/kg/day

FQPA SF = 1

aPAD = 

 FQPA SF

Acute RfD

= 0.1 mg/kg/day

Acute neurotoxicity study in the rat 

(zeta-cypermethrin). 

LOAEL = 50 mg/kg/day based on 

clinical signs of neurotoxicity and 

changes in the FOB.

Chronic Dietary

(All populations)

NOAEL = 6 

mg/kg/day

UF = 100

Chronic RfD = 0.06 

mg/kg/day

FQPA SF = 1

cPAD = 

 FQPA SF

Chronic RfD

= 0.06 mg/kg/day

Chronic feeding study in the dog. 

LOAEL = 20.4/18.1mg/kg/day based 

on clinical signs of neurotoxicity and 

mortality in males and decreased body 

weight and body weight gain in 

females.

Short-term

Incidental Oral 

(1 - 30 days)

NOAEL = 7.4 

mg/kg/day

Residential LOC for 

MOE = 100

Occupational LOC for 

MOE = N/A

Developmental neurotoxicity study in 

the rat (zeta-cypermethrin). 

LOAEL = 17 mg/kg/day based on 

decreased body weight in the offspring

Intermediate- term

Incidental Oral 

(1 - 6 months)

NOAEL = 7.4 

mg/kg/day

Residential LOC for 

MOE = 100

Occupational LOC for 

MOE = N/A

Developmental neurotoxicity study in 

the rat (zeta-cypermethrin). 

LOAEL = 17 mg/kg/day based on 

decreased body weight in the 

offspring.

Short and 

Intermediate-Term

Dermal

(Infants and 

children only; 1 

day - 6 months)

NOAEL = 7.4 

mg/kg/day

(Dermal absorption 

factor = 2.5%)

Residential LOC for 

MOE = 100

Developmental neurotoxicity study in 

the rat (zeta-cypermethrin). 

LOAEL = 17 mg/kg/day based on 

decreased body weight in the 

offspring.

Short and 

Intermediate-Term

Dermal

(Adults workers; 1 

day - 6 months)

None None No systemic effects in 21-day dermal 

study (zeta-cypermethrin) up to 1000 

mg/kg/day & no developmental 

concern. No hazard identified to 

support quantification of risk.

Dermal 

Long-Term

(> 6 months)

Oral NOAEL = 6 

mg/kg/day 

(Dermal absorption 

factor = 2.5%)

Residential LOC for 

MOE = 100

Occupational LOC for 

MOE = 100

Chronic feeding study in the dog. 

LOAEL = 20.4/18.1 mg/kg/day based 

on clinical signs of neurotoxicity and 

mortality in males, and decreased body 

weight and body weight gain in 

females. 

Short and 

Intermediate-Term

Inhalation

(1 - 6 months)

NOAEL = 0.01 mg 

ai/L 

(2.7 mg/kg/day)

Residential LOC for 

MOE = 100

Occupational LOC for 

MOE = 100

21-day inhalation study in the rat.

LOAEL = 0.05 mg/kg/day based on 

decreases in body weight and 

salivation.
19

Summary of Toxicological Doses and Endpoints for Zeta-cypermethrin/cypermethrin for Use in Human 

Risk Assessments (Studies are conducted with cypermethrin unless specified otherwise).

Exposure/

Scenario

Dose Used in Risk 

Assessment, UF 

FQPA SF and Level 

of Concern for Risk 

Assessment

Study and Toxicological Effects

Long-Term

Inhalation 

(> 6 months)

NOAEL = 0.01mg 

ai/L 

(2.7 mg/kg/day)

Residential LOC for 

MOE = 300

Occupational LOC for 

MOE = 300

– for the lack of an 

alternative study. 

Route-to-route 

estimation would result 

in less protective 

endpoint.

21-Day inhalation study in the rat.

LOAEL = 0.05 mg/kg/day based on 

decreases in body weight and 

salivation.

Cancer (oral, 

dermal, inhalation)

Classification: Possible human carcinogen. No quantification required. The chronic 

RfD/PAD will adequately account for all chronic toxicity effects, including 

carcinogenicity, likely to result from exposure to this pesticide. 

UF = uncertainty factor, FQPA SF = Any additional safety factor retained to account for data deficiencies or 

residual concerns unique to the FQPA, NOAEL = no observed adverse effect level, LOAEL = lowest observed 

adverse effect level, PAD = population adjusted dose (a = acute, c = chronic) RfD = reference dose, MOE = margin 

of exposure, LOC = level of concern, NA = not applicable.
Attachment 3. Cypermethrin and Zeta-Cypermethrin Products and Use Sites

The currently registered products containing cypermethrin and zeta-cypermethrin as an active ingredient are listed in the table below. 

Cypermethrin Products and Use Sites.

Formulation 

Type

% Active 

Ingredient

EPA Reg. 

No.

Registered Product 

Name

Registered Use Sites

LIQUID (L) 30.6 1381-188 BATTERY 2.5 EC AGRICULTURAL FOOD CROPS

0.6 270-250 FARNAM CRASH! FLY 

SPRAY CONCENTRATE

ANIMAL TREATMENT 

READY-TO-USE 

(RTU)

0.1 1543-1 WFY0901 AGRICULTURAL/FARM STRUCTURES/BARNS/BARNYARDS/AUCTION BARNS, ANIMAL TREATMENT 

0.515 73049-453 CYPER-ACTIVE 515 ANIMAL KENNELS/SLEEPING QUARTERS , BARNS, BATHROOM/HARD SURFACES, COMMERCIAL/ 

INDUSTRIAL PREMISES (INDOOR), COMMERCIAL STORAGES/WAREHOUSES COMMERCIAL, 

TRANSPORTATION FACILITIES, HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY),

HOUSEHOLD/DOMESTIC DWELLINGS (INDOOR), NONFOOD STORAGE AREAS, PET LIVING/SLEEPING 

QUARTERS, SHIPS AND BOATS

0.15 270-251 FARNAM CRASH FLY 

SPRAY

ANIMAL TREATMENT

0.15 270-253 FARNAM CRASH! WIPEON 

INSECTICIDE/REPELLENT

ANIMAL TREATMENT

1.0 53883-150 CYPER 1% HORSE SPRAY ANIMAL TREATMENT

17.5 53883-152 CYPER HORSE SPOT-ON ANIMAL TREATMENT

1.0 69332-5 ECTOMETHRIN H20 

EQUINE SPRAY

ANIMAL TREATMENT

0.21 100-1303 CYPERMETHRIN ME 0.2% 

RTU

HOUSEHOLD/DOMESTIC DWELLINGS (INDOOR/OUTDOOR), ORNAMENTAL AND/OR SHADE TREES

PATHS/PATIOS, RESIDENTIAL LAWNS, WOOD PROTECTION TREATMENT (INDOOR)

PRESSURIZED 

LIQUID (PRL)

0.05 1021-1856 MULTICIDE 28661 BATHROOM PREMISES/HARD SURFACES, COMMERCIAL STORAGES/WAREHOUSES, 

HOUSEHOLD/DOMESTIC DWELLINGS, INDOOR FOOD HANDLING AREAS, PET LIVING/SLEEPING 

QUARTERS, SOLID WASTE CONTAINERS, PET LIVING/SLEEPING QUARTERS

0.05 73049-157 CYPERMETHRIN/ESBIOTH

RIN/PIPERONYL 

BUTOXIDE 

0.05%/0.1%/0.4% APS

ANIMAL KENNELS/SLEEPING QUARTERS, BATHROOM PREMISES/HARD SURFACES

COMMERCIAL/ INDUSTRIAL PREMISES (OUTDOOR), COMMERCIAL TRANSPORTATION FACILITIES, 

DAIRIES/CHEESE PROCESSING PLANT , DAIRY FARM MILK STORAGE ROOMS/HOUSES/SHEDS

ANIMAL TREATMENT (DOGS), DRAINAGE SYSTEMS, EATING ESTABLISHMENTS, EGG PACKING PLANTS 

(COMMERCIAL), FOOD STORES/MARKETS/SUPERMARKETS PREMISES, GREENHOUSE-EMPTY

GREENHOUSES-IN USE, ANIMAL TREATMENT, HOSPITALS/MEDICAL INSTITUTIONS 

(HUMAN/VETERINARY), HOUSEHOLD/DOMESTIC DWELLINGS, SWIMMING POOL WATER SYSTEMS

SEED HOUSES/STORES/STORAGE AREAS/WAREHOUSES, PAVED AREAS (PRIVATE OADS/SIDEWALKS)

PATHS/PATIOS, PET LIVING/SLEEPING QUARTERS, REFUSE/SOLID WASTE SITES (OUTDOOR),

PUBLIC BUILDINGS/STRUCTURES 

0.03 1021-1855 MULTICIDE CRAWLING 

INSECT KILLER

RESIDENTIAL HOUSEHOLD/DOMESTIC DWELLINGS INDOOR PREMISES

1.716 4822-452 RAID FOGGER K HOUSEHOLD/DOMESTIC DWELLINGS (INDOOR)

0.824 73049-454 CYPER-ACTIVE E2 WB HOUSEHOLD/DOMESTIC DWELLINGS, INDOOR NONFOOD HANDLING AREAS
21

TRA

73049-455 CYPER-ACTIVE AS2 TRA HOUSEHOLD/DOMESTIC DWELLINGS, INDOOR NONFOOD HANDLING AREAS

0.515 9688-249 CHEMSICO AEROSOL 

INSECTICIDE CF

HOUSEHOLD/DOMESTIC DWELLINGS, PET LIVING/SLEEPING QUARTERS

0.86 9688-252 CHEMSICO AEROSOL 

INSECTICIDE NMR

HOUSEHOLD/DOMESTIC DWELLINGS

0.6 9688-254 CHEMSICO AEROSOL 

INSECTICIDE GBR

HOUSEHOLD/DOMESTIC DWELLINGS

0.03 1021-2559 MGK 29461 HOUSEHOLD/DOMESTIC DWELLINGS INDOOR NONFOOD HANDLING AREAS (INDOOR RESIDENTIAL)

0.05 4822-553 RWH 33 NONAGRICULTURAL UNCULTIVATED AREAS/SOILS

498-190 CHAMPION SPRAYON 

INDOOR FOGGER

HOUSEHOLD/DOMESTIC DWELLINGS INDOOR NONFOOD HANDLING AREAS, PET LIVING/SLEEPING 

QUARTERS, SHIPS AND BOATS, PET LIVING/SLEEPING QUARTERS

0.1 4822-447 RAID ANT & ROACH 17 HOUSEHOLD/DOMESTIC DWELLINGS INDOOR PREMISES

WETTABLE 

POWDER (WP)

40 100-990 DEMON WP INSECTICIDE AGRICULTURAL/FARM STRUCTURES/AIRPORTS/LANDING FIELDS, ANIMAL HOUSES, 

COMMERCIAL/INDUSTRIAL (INDOOR), COMMERCIAL TRANSPORTATION FACILITIES, EATING 

ESTABLISHMENTS, FOOD PROCESSING PLANT, FOOD STORES/MARKETS/SUPERMARKETS PREMISES

GREENHOUSES-IN USE, HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY), 

HOUSEHOLD/DOMESTIC DWELLINGS, NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES, 

NONAGRICULTURAL RIGHTS-OF-WAY, ORNAMENTAL AND/OR SHADE TREES, LAWNS AND TURF

PATHS/PATIOS, POULTRY PROCESSING PLANT, SEWAGE DISPOSAL AREAS, UTILITY POLES / RIGHT-OFWAY, WOOD PROTECTION TREATMENT 

40 279-3070 CYNOFF WP INSECTICIDE AIRPORTS/AUTOMOBILES, TAXIS, LIMOUSINES, RECREATIONAL VEHICLES, & TIRES, BARNS, 

COMMERCIAL/INDUSTRIAL PREMISES (INDOOR), EATING ESTABLISHMENTS, FOOD PROCESSING 

PLANT, FOOD STORES/MARKETS/SUPERMARKETS PREMISES, GREENHOUSES-IN USE, 

HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) HOUSEHOLD/DOMESTIC DWELLINGS, 

NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES, ORNAMENTAL AND/OR SHADE TREES, 

LAWNS AND TURF, PATHS/PATIOS, RECREATIONAL AREAS, RESIDENTIAL LAWNS, SOLID WASTE SITES 

(OUTDOOR), STORAGES/WAREHOUSES PREMISES, COMMERCIAL TRANSPORTATION FACILITIES, 

DRAINAGE SYSTEMS EATING ESTABLISHMENTS, EGG HANDLING ROOMS (COMMERCIAL), ELECTRICAL 

SUPPLIES/EQUIPMENT, FEED MILLS/FEED PROCESSING PLANTS , INDUSTRIAL / CONSTRUCTION AREAS 

(OUTDOOR), MEAT/POULTRY PROCESSING PLANT, WOOD PROTECTION TREATMENT 

40 100-1000 DEMON WP INSECTICIDE 

IN WATER-SOLUBLE 

PACKETS

COMMERCIAL/INDUSTRIAL PREMISES (INDOOR) , COMMERCIAL STORAGES/WAREHOUSES,

COMMERCIAL TRANSPORTATION FACILITIES, DRAINAGE SYSTEMS, EATING ESTABLISHMENTS, EGG 

HANDLING ROOMS (COMMERCIAL), ELECTRICAL SUPPLIES/EQUIPMENT, FEED MILLS/FEED 

PROCESSING PLANTS, FOOD PROCESSING PLANT , GREENHOUSES-IN USE, HOSPITALS/MEDICAL 

INSTITUTIONS (HUMAN/VETERINARY), HOUSEHOLD/DOMESTIC DWELLINGS, INDUSTRIAL / 

CONSTRUCTION AREAS (OUTDOOR),MEAT PROCESSING PLANT, ORNAMENTAL LAWNS AND TURF, 

SOLID WASTE SITES (OUTDOOR), WOOD PROTECTION TREATMENT 

40 53883-29 VIPER WP

BONIDE CYPER WSP

INSECTICIDE

COMMERCIAL/INDUSTRIAL PREMISES (INDOOR), COMMERCIAL TRANSPORTATION FACILITIES, EATING 

ESTABLISHMENTS , EGG HANDLING ROOMS (COMMERCIAL), FOOD PROCESSING PLANT, FOOD 

STORES/MARKETS/SUPERMARKETS PREMISES, HOSPITALS/MEDICAL INSTITUTIONS 

(HUMAN/VETERINARY), HOUSEHOLD/DOMESTIC DWELLINGS, MEAT/POULTRY PROCESSING PLANT, 

NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES, NONAGRICULTURAL RIGHTS-OF-WAY, 

ORNAMENTAL AND/OR SHADE TREES, LAWNS AND TURF, PATHS/PATIO, SOLID WASTE SITES 

(OUTDOOR), WOOD PROTECTION TREATMENT 

40 4-482 HOUSEHOLD/DOMESTIC DWELLINGS, PATHS/PATIOS, REFUSE/SOLID WASTE SITES (OUTDOOR)

RESIDENTIAL LAWNS, WOOD PROTECTION TREATMENT 

EMULSIFIABLE 

CONCENTRATE 

(EC)

25.3 100-1004 DEMON EC INSECTICIDE BATHROOM PREMISES/HARD SURFACES, COMMERCIAL/INDUSTRIAL (OUTDOOR), COMMERCIAL 

STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTATION FACILITIES, DRAINAGE SYSTEMS, 

EATING ESTABLISHMENTS, FOOD/GROCERY/MARKETING/STORAGE/DISTRIBUTION FACILITY, FOOD 
22

PROCESSING PLANT, HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY), 

HOUSEHOLD/DOMESTIC DWELLINGS (OUTDOOR), ORNAMENTAL AND/OR SHADE TREES, 

HERBACEOUS PLANTS, LAWNS AND TURF, ORNAMENTAL NONFLOWERING PLANTS/ WOODY SHRUBS 

AND VINES, SOLID WASTE SITES, WOOD PROTECTION TREATMENT 

25.3 100-1006 PROBUILD TC 

TERMITICIDE

BARNS, COMMERCIAL/INDUSTRIAL PREMISES (INDOOR/OUTDOOR), COMMERCIAL 

STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTATION FACILITIES, EATING ESTABLISHMENTS,

FOOD PROCESSING PLANT, GREENHOUSE-EMPTY, HOSPITALS/MEDICAL INSTITUTIONS , 

(HUMAN/VETERINARY), HOUSEHOLD/DOMESTIC DWELLINGS, NONAGRICULTURAL OUTDOOR 

BUILDINGS/STRUCTURES, ORNAMENTAL AND/OR SHADE TREES, ORNAMENTAL LAWNS AND TURF, 

ORNAMENTAL WOODY SHRUBS AND VINES, PATHS/PATIOS, RESIDENTIAL LAWNS, SHIPS AND BOATS

UTILITY POLES / RIGHT-OF-WAY, WOOD PROTECTION TREATMENT 

25.3 100-1109 CYPER EC INSECTICIDE COMMERCIAL/INDUSTRIAL PREMISES, FENCEROWS, HOUSEHOLD/DOMESTIC DWELLINGS, 

ORNAMENTAL AND/OR SHADE TREES, WOOD PROTECTION TREATMENT 

25.3 100-1218 DEMON MAX 

INSECTICIDE

BARNS, COMMERCIAL STORAGES/WAREHOUSES PREMISES, COMMERCIAL TRANSPORTATION 

FACILITIES, EATING ESTABLISHMENTS, FOOD PROCESSING PLANT, GREENHOUSE-EMPTY, 

HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY), HOUSEHOLD/DOMESTIC DWELLINGS, 

NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES, ORNAMENTAL AND/OR SHADE TREES, 

LAWNS AND TURF, ORNAMENTAL WOODY SHRUBS AND VINES, PATHS/PATIOS, SHIPS AND BOATS, 

UTILITY POLES / RIGHT-OF-WAY, WOOD PROTECTION TREATMENT 

2.08 100-1302 CYPERMETHRIN ME 2.0% 

CONCENTRATE

HOUSEHOLD/DOMESTIC DWELLINGS, ORNAMENTAL AND/OR SHADE TREES, LAWNS AND TURF, 

ORNAMENTAL WOODY SHRUBS AND VINES, PATHS/PATIOS, WOOD PROTECTION TREATMENT 

24.8 228-616 CYPERMETHRIN E-PRO 

TERMITICIDE/INSECTICID

E

AIRPORTS/LANDING FIELDS, AUTOMOBILES, TAXIS, LIMOUSINES, RECREATIONAL VEHICLES, & TIRES

BARNS, COMMERCIAL TRANSPORTATION FACILITIES, EATING ESTABLISHMENTS, FOOD 

STORES/MARKETS/SUPERMARKETS, GREENHOUSE-EMPTY, HOSPITALS/MEDICAL INSTITUTIONS

(HUMAN/VETERINARY), HOUSEHOLD/DOMESTIC DWELLINGS, NONAGRICULTURAL OUTDOOR 

BUILDINGS/STRUCTURES, ORNAMENTAL AND/OR SHADE TREES, LAWNS AND TURF,

ORNAMENTAL NONFLOWERING PLANTS/WOODY SHRUBS AND VINES, PATHS/PATIOS, PUBLIC 

BUILDINGS/STRUCTURES, RECREATIONAL AREAS, SOLID WASTE SITES (OUTDOOR), RESIDENTIAL 

LAWNS, UTILITY POLES / RIGHT-OF-WAY, WOOD PROTECTION TREATMENT 

30.6 279-3027 AMMO 2.5 EC 

INSECTICIDE

AGRICULTURAL FOOD CROPS

24.8 279-3081 CYNOFF EC INSECTICIDE AIRPORTS/LANDING FIELDS, AUTOMOBILES, TAXIS, LIMOUSINES, RECREATIONAL VEHICLES, & TIRES, 

COMMERCIAL/ INDUSTRIAL PREMISES, COMMERCIAL STORAGES/WAREHOUSES, COMMERCIAL 

TRANSPORTATION FACILITIES, EATING ESTABLISHMENTS, FOOD PROCESSING PLANT, FOOD 

STORES/MARKETS/SUPERMARKETS, GREENHOUSE-EMPTY, HOSPITALS/MEDICAL INSTITUTIONS 

(HUMAN/VETERINARY), HOUSEHOLD/DOMESTIC DWELLINGS, NONAGRICULTURAL OUTDOOR 

BUILDINGS/STRUCTURES, PATHS/PATIOS, SOLID WASTE SITES ,RESIDENTIAL LAWNS

24.8 279-3082 PREVAIL FT TERMITICIDE COMMERCIAL/INDUSTRIAL PREMISES, COMMERCIAL STORAGES/WAREHOUSES PREMISES, 

COMMERCIAL TRANSPORTATION FACILITIES, FOOD PROCESSING PLANT, GREENHOUSE-EMPTY, 

HOSPITALS/MEDICAL INSTITUTIONS, HOUSEHOLD/DOMESTIC DWELLINGS, NONAGRICULTURAL 

RIGHTS-OF-WAY, ORNAMENTAL AND/OR SHADE TREES, SOLID WASTE SITES, RESIDENTIAL LAWNS, 

WOOD PROTECTION TREATMENT

26 3-12 HARRIS HOME PEST 

CONTROL CONCENTRATE

ANIMAL KENNELS/SLEEPING QUARTERS, AUTOMOBILES, TAXIS, LIMOUSINES, RECREATIONAL 

VEHICLES, & TIRES, BARNS, COMMERCIAL STORAGES/WAREHOUSES, EATING ESTABLISHMENTS, EGG 

PACKING PLANTS, FEED MILLS/FEED PROCESSING PLANTS, FOOD PROCESSING PLANT, FOOD 

STORES/MARKETS/SUPERMARKETS,

HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY), HOUSEHOLD/DOMESTIC DWELLINGS, 

NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES, NURSERY STOCK ,ORNAMENTAL 

HERBACEOUS PLANTS, LAWNS AND TURF, ORNAMENTAL NONFLOWERING PLANTS/WOODY SHRUBS 

AND VINES, PATHS/PATIOS, PET LIVING/SLEEPING QUARTERS, SEED HOUSES/STORES/STORAGE 
23

AREAS/WAREHOUSES

30.6 34704-875 CYPERMETHRIN 2.5 EC AGRICULTURAL FOOD CROPS

25.3 34704-887 CYPERMETHRIN 25 BARNS, COMMERCIAL/INDUSTRIAL PREMISES, HOUSEHOLD/DOMESTIC DWELLINGS, 

NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES, ORNAMENTAL AND/OR SHADE TREES, 

ORNAMENTAL LAWNS AND TURF, ORNAMENTAL WOODY SHRUBS AND VINES, PATHS/PATIOS, SOLID 

WASTE SITES, RESIDENTIAL LAWNS, UTILITY POLES / RIGHT-OF-WAY, WOOD PROTECTION 

TREATMENT 

24.8 34704-897 CYPRO 

TERMITICIDE/INSECTICID

E

AGRICULTURAL/FARM STRUCTURES/BUILDINGS, BARNS, COMMERCIAL/INDUSTRIAL PREMISES, 

COMMERCIAL STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTATION FACILITIESNONFEED/NONFOOD, EATING ESTABLISHMENTS, FOOD PROCESSING PLANT, FOOD 

STORES/MARKETS/SUPERMARKETS, GREENHOUSE-EMPTY, HOSPITALS/MEDICAL INSTITUTIONS 

(HUMAN/VETERINARY), HOUSEHOLD/DOMESTIC DWELLINGS, NONAGRICULTURAL OUTDOOR 

BUILDINGS/STRUCTURES, RIGHTS-OF-WAY, NONAGRICULTURAL UNCULTIVATED AREAS/SOILS, 

ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/NONFLOWERING PLANTS/WOODY 

SHRUBS AND VINES, LAWNS AND TURF, PATHS/PATIOS, RECREATIONAL AREAS, RECREATION AREA 

LAWNS, SOLID WASTE SITES, RESIDENTIAL LAWNS, UTILITY POLES , WOOD PROTECTION TREATMENT 

26 4-427 BONIDE CYPERACTIVE ANIMAL KENNELS/SLEEPING QUARTERS, AUTOMOBILES, TAXIS, LIMOUSINES, RECREATIONAL 

VEHICLES, & TIRES, COMMERCIAL/INDUSTRIAL PREMISES, COMMERCIAL STORAGES/WAREHOUSES, 

COMMERCIAL TRANSPORTATION FACILITIES, EATING ESTABLISHMENTS, EGG PACKING PLANTS, FEED 

MILLS/FEED PROCESSING PLANTS, FOOD PROCESSING PLANT, GREENHOUSE-EMPTY ,GREENHOUSES-IN 

USE, ANIMAL TREATMENT (HORSES), HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY), 

HOUSEHOLD/DOMESTIC DWELLINGS, LAWNS AND TURF, PATHS/PATIOS, SOLID WASTE SITES, SEED 

HOUSES/STORES/STORAGE AREAS

26 45385-94 IGUANA ANIMAL KENNELS/SLEEPING QUARTERS, COMMERCIAL/INDUSTRIAL PREMISES, COMMERCIAL 

STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTATION FACILITIES, DRAINAGE SYSTEMS, EATING 

ESTABLISHMENTS, FOOD PROCESSING PLANT, FOOD STORES/MARKETS/SUPERMARKETS, ANIMAL 

TREATMENTS (HORSES), HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY), 

HOUSEHOLD/DOMESTIC DWELLING, ORNAMENTAL LAWNS AND TURF, SOLID WASTE SITES, SEED 

HOUSES/STORES/STORAGE AREAS

30.6 53883-137 CYPER AG II AGRICULTURAL FOOD CROPS

24.8 53883-247 CYPER TC II BARNS, COMMERCIAL/INDUSTRIAL PREMISES, HOUSEHOLD/DOMESTIC DWELLINGS , 

INDUSTRIAL/CONSTRUCTION AREAS, NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES, 

NONAGRICULTURAL UNCULTIVATED AREAS/SOILS, ORNAMENTAL AND/OR SHADE TREES/WOODY 

SHRUBS AND VINES, LAWNS AND TURF, PATHS/PATIOS, SOLID WASTE SITES, RESIDENTIAL LAWNS, 

UTILITY POLES / RIGHT-OF-WAY WOOD PROTECTION TREATMENT 

25.4 53883-27 VIPER INSECTICIDE 

CONCENTRATE

BARNS, BATHROOM PREMISES/HARD SURFACES, COMMERCIAL/INDUSTRIAL PREMISES, COMMERCIAL 

STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTATION FACILITIES, DRAINAGE SYSTEMS, EATING 

ESTABLISHMENTS, FENCEROWS, FOOD PROCESSING PLANT, GREENHOUSES-IN USE, 

HOSPITALS/MEDICAL INSTITUTIONS, HOUSEHOLD/DOMESTIC DWELLINGS, ORNAMENTAL 

HERBACEOUS PLANTS/ WOODY SHRUBS AND VINES, LAWNS AND TURF, SOLID WASTE SITES, WOOD 

PROTECTION TREATMENT 

26 53883-278 CYPER LO BARNS, COMMERCIAL/INDUSTRIAL LAWNS, COMMERCIAL/INDUSTRIAL PREMISES, COMMERCIAL 

STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTATION FACILITIES, EATING ESTABLISHMENTS, 

FOOD PROCESSING PLANT, FOOD STORES/MARKETS/SUPERMARKETS, GREENHOUSE-EMPTY, 

HOSPITALS/MEDICAL INSTITUTIONS, HOUSEHOLD/DOMESTIC DWELLINGS, NONAGRICULTURAL 

OUTDOOR BUILDINGS/STRUCTURES, ORNAMENTAL AND/OR SHADE TREES/ WOODY SHRUBS AND 

VINES, LAWNS AND TURF, PATHS/PATIOS, SOLID WASTE SITES, RESIDENTIAL LAWNS, SHIPS AND 

BOATS, UTILITY POLES / RIGHT-OF-WAY, WOOD PROTECTION TREATMENT 

25.4 53883-92 CYPER TC INSECTICIDE BARNS, COMMERCIAL/INDUSTRIAL PREMISES, HOUSEHOLD/DOMESTIC DWELLINGS , INDUSTRIAL / 

CONSTRUCTION AREAS, NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES, ORNAMENTAL 
24

AND/OR SHADE TREES/ WOODY SHRUBS AND VINES, LAWNS AND TURF, PATHS/PATIOS, SOLID WASTE 

SITES, RESIDENTIAL LAWNS, UTILITY POLES / RIGHT-OF-WAY, WOOD PROTECTION TREATMENT TO 

BUILDINGS/PRODUCTS OUTDOOR

24.8 70506-19 UP-CYDE PRO 2.0 EC 

TERMITICIDE/INSECTICID

E

BARNS, BATHROOM PREMISES/HARD SURFACES , COMMERCIAL/INDUSTRIAL PREMISES, COMMERCIAL 

STORAGES/WAREHOUSES, DRAINAGE SYSTEMS, EATING ESTABLISHMENTS, ENCEROWS/HEDGEROWS, 

FOOD PROCESSING PLANT, FOOD STORES/MARKETS/SUPERMARKETS, GREENHOUSE-EMPTY, 

HOSPITALS/MEDICAL INSTITUTIONS, HOUSEHOLD/DOMESTIC DWELLINGS, NONAGRICULTURAL 

OUTDOOR BUILDINGS/STRUCTURES, ORNAMENTAL AND/OR SHADE TREES/WOODY SHRUBS AND 

VINES, SOLID WASTE SITES, RESIDENTIAL LAWNS

WOOD PROTECTION TREATMENT 

30.6 70506-20 UP-CYDE 2.5 EC 

AGRICULTURAL 

INSECTICIDE

AGRICULTURAL FOOD CROPS

30.6 70506-21 CYPERMETHRIN 2.5 EC 

TERMITICIDE/INSECTICID

E

BARNS, BATHROOM PREMISES/HARD SURFACES, COMMERCIAL/INDUSTRIAL PREMISES, COMMERCIAL 

STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTATION FACILITIES, DRAINAGE SYSTEMS , 

EATING ESTABLISHMENTS, FOOD PROCESSING PLANT, GREENHOUSES-IN USE , HOSPITALS/MEDICAL 

INSTITUTIONS, HOUSEHOLD/DOMESTIC DWELLINGS, NONAGRICULTURAL OUTDOOR 

BUILDINGS/STRUCTURES, RIGHTS-OF-WAY, SOLID WASTE SITES, RESIDENTIAL LAWNS, WOOD 

PROTECTION TREATMENT 

26 73049-154 CYPER-ACTIVE 2.14 EC ANIMAL KENNELS/SLEEPING QUARTERS, AUTOMOBILES, TAXIS, LIMOUSINES, RECREATIONAL 

VEHICLES, & TIRES, BARNS, COMMERCIAL/INDUSTRIAL LAWNS, COMMERCIAL/INDUSTRIAL PREMISES, 

COMMERCIAL STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTATION FACILITIES, EATING 

ESTABLISHMENTS, EGG HANDLING ROOMS, FEED MILLS/FEED PROCESSING PLANTS, FOOD 

STORES/MARKETS/SUPERMARKETS, GREENHOUSE-EMPTY, HOSPITALS/MEDICAL INSTITUTIONS, 

HOUSEHOLD/DOMESTIC DWELLINGS, NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES, 

ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/NONFLOWERING PLANTS/WOODY 

SHRUBS AND VINES, LAWNS AND TURF, PATHS/PATIOS, PET LIVING/SLEEPING QUARTERS, 

RECREATION AREA LAWNS, SOLID WASTE SITES, RESIDENTIAL LAWNS, SEED 

HOUSES/STORES/STORAGE , SHIPS AND BOATS

30.6 83222-7 CYPER G-AG 2.5 EC AGRICULTURAL FOOD CROPS

Zeta-Cypermethrin Products and Use Sites.

Formulation 

Type

% Active 

Ingredient

EPA Reg. 

No.

Registered Product 

Name

Registered Use Sites

DISPERSIBLE 

FLOWABLE (DF)

6.7 279-3333 F6305 WDG INSECTICIDE COTTON

EMULSION, OIL 

IN WATER (EW)

0.075 279-9535 F6141 EW INSECTICIDE HOUSEHOLD/DOMESTIC DWELLINGS , LAWNS AND TURF, ORNAMENTAL AND/OR SHADE 

TREES/HERBACEOUS PLANTS/NONFLOWERING PLANTS/WOODY SHRUBS AND VINES, PATHS/PATIOS, 

RESIDENTIAL LAWNS/PLANST AND WEGETABLES

GRANULAR (R) 0.344 279-3297 0.344% F0570 OTC 

GRANULAR INSECTICIDE

ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/NONFLOWERING PLANTS/WOODY 

SHRUBS AND VINES, RESIDENTIAL LAWNS

0.258 279-3298 0.258% F0570 OTC 

GRANULAR INSECTICIDE

ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/NONFLOWERING PLANTS/WOODY 

SHRUBS AND VINES, RESIDENTIAL LAWNS

0.129 279-3299 0.129% F0570 OTC 

GRANULAR INSECTICIDE

ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/NONFLOWERING PLANTS/WOODY 

SHRUBS AND VINES, RESIDENTIAL LAWNS

0.150 279-3300 F0570 0.15 GRANULAR 

INSECTICIDE

COMMERCIAL/INDUSTRIAL LAWNS, COMMERCIAL/ INDUSTRIAL PREMISES, ELECTRICAL 

SUPPLIES/EQUIPMENT, HOUSEHOLD/DOMESTIC DWELLINGS, LAWNS AND TURF, RECREATIONAL 

AREAS LAWNS, RESIDENTIAL LAWNS
25

0.05 279-3342 F6131 G INSECTICIDE COMMERCIAL/INDUSTRIAL LAWNS, COMMERCIAL/ INDUSTRIAL PREMISES, ELECTRICAL 

SUPPLIES/EQUIPMENT, GREENHOUSE-EMPTY, GREENHOUSES-IN USE, HOUSEHOLD/DOMESTIC 

DWELLINGS, INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR), NONAGRICULTURAL OUTDOOR 

BUILDINGS/STRUCTURES, RIGHTS-OF-WAY/FENCEROWS/HEDGEROWS, NONAGRICULTURAL 

UNCULTIVATED AREAS/SOILS, ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/SHRUBS 

AND VINES, RECREATIONAL AREAS, RESIDENTIAL LAWNS

0.05 279-3343 F6132 G INSECTICIDE COMMERCIAL/INDUSTRIAL LAWNS, COMMERCIAL/ INDUSTRIAL PREMISES, ELECTRICAL 

SUPPLIES/EQUIPMENT, GREENHOUSE-EMPTY, GREENHOUSES-IN USE, HOUSEHOLD/DOMESTIC 

DWELLINGS, INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR), NONAGRICULTURAL OUTDOOR 

BUILDINGS/STRUCTURES, RIGHTS-OF-WAY/FENCEROWS/HEDGEROWS, NONAGRICULTURAL 

UNCULTIVATED AREAS/SOILS, ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/SHRUBS 

AND VINES, RECREATIONAL AREAS, RESIDENTIAL LAWNS

0.05 279-3344 F6133 G INSECTICIDE COMMERCIAL/INDUSTRIAL LAWNS, COMMERCIAL/ INDUSTRIAL PREMISES, ELECTRICAL 

SUPPLIES/EQUIPMENT, GREENHOUSE-EMPTY, GREENHOUSES-IN USE, HOUSEHOLD/DOMESTIC 

DWELLINGS, INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR), NONAGRICULTURAL OUTDOOR 

BUILDINGS/STRUCTURES, RIGHTS-OF-WAY/FENCEROWS/HEDGEROWS, NONAGRICULTURAL 

UNCULTIVATED AREAS/SOILS, ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/SHRUBS 

AND VINES, RECREATIONAL AREAS, RESIDENTIAL LAWNS

0.05 279-3345 F6135 G INSECTICIDE COMMERCIAL/INDUSTRIAL LAWNS, COMMERCIAL/ INDUSTRIAL PREMISES, ELECTRICAL 

SUPPLIES/EQUIPMENT, GREENHOUSE-EMPTY, GREENHOUSES-IN USE, HOUSEHOLD/DOMESTIC 

DWELLINGS, INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR), NONAGRICULTURAL OUTDOOR 

BUILDINGS/STRUCTURES, RIGHTS-OF-WAY/FENCEROWS/HEDGEROWS, NONAGRICULTURAL 

UNCULTIVATED AREAS/SOILS, ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/SHRUBS 

AND VINES, RECREATIONAL AREAS, RESIDENTIAL LAWNS

0.029 279-3352 F6130 G INSECTICIDE NONAGRICULTURAL FOOD CROPS, ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS 

PLANTS/NONFLOWERING PLANTS/WOODY SHRUBS AND VINES, RESIDENTIAL LAWNS

0.05 279-9547 F6132 GC GRANULAR 

INSECTICIDE

COMMERCIAL/INDUSTRIAL LAWNS, COMMERCIAL/ INDUSTRIAL PREMISES, ELECTRICAL 

SUPPLIES/EQUIPMENT, GREENHOUSE-EMPTY, GREENHOUSES-IN USE, HOUSEHOLD/DOMESTIC 

DWELLINGS, INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR), NONAGRICULTURAL OUTDOOR 

BUILDINGS/STRUCTURES, RIGHTS-OF-WAY/FENCEROWS/HEDGEROWS, NONAGRICULTURAL 

UNCULTIVATED AREAS/SOILS, ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/SHRUBS 

AND VINES, RECREATIONAL AREAS, RESIDENTIAL LAWNS, GOLF COURSE TURF, 

GREENHOUSE-EMPTY, ORNAMENTAL SOD FARM (TURF)

0.05 279-9552 F6139-2 INSECTICIDE COMMERCIAL/INDUSTRIAL LAWNS, COMMERCIAL/ INDUSTRIAL PREMISES, ELECTRICAL 

SUPPLIES/EQUIPMENT, GREENHOUSE-EMPTY, GREENHOUSES-IN USE, HOUSEHOLD/DOMESTIC 

DWELLINGS, INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR), NONAGRICULTURAL OUTDOOR 

BUILDINGS/STRUCTURES, RIGHTS-OF-WAY/FENCEROWS/HEDGEROWS, NONAGRICULTURAL 

UNCULTIVATED AREAS/SOILS, ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/SHRUBS 

AND VINES, RECREATIONAL AREAS, RESIDENTIAL LAWNS

DUST (D) 0.075 279-3259 ZETA-CYP DUST 

INSECTICIDE

AIRPORTS/LANDING FIELDS, BATHROOM PREMISES/HARD SURFACES, COMMERCIAL/INDUSTRIAL 

LAWNS, COMMERCIAL/ INDUSTRIAL PREMISES, COMMERCIAL STORAGES/WAREHOUSES, 

COMMERCIAL TRANSPORTATION FACILITIES-NONFEED/NONFOOD, EATING ESTABLISHMENTS, 

ELECTRICAL SUPPLIES/EQUIPMENT, FOOD PROCESSING PLANT PREMISES, GREENHOUSE-EMPTY, 

GREENHOUSES-IN USE, HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY),

HOUSEHOLD/DOMESTIC DWELLINGS, ORNAMENTAL AND/OR SHADE TREES, ORNAMENTAL 

HERBACEOUS PLANTS/NONFLOWERING PLANTS/WOODY SHRUBS AND VINES, PATHS/PATIOS, 

RECREATIONAL AREAS, RECREATION AREA LAWNS, SOLID WASTE CONTAINERS , RESIDENTIAL 

LAWNS, SEWAGE SYSTEMS

0.075 39039-9 Y-TEX PYTHON DUST 

LIVESTOCK INSECTICIDE

ANIMAL TREATMENT 
26

READY-TO-USE 

(RTU)

279-3347 0.35 F6570 EW MASTER 

INSECTICIDE

DECIDUOUS FRUIT TREES, HOUSEHOLD/DOMESTIC DWELLINGS, NONAGRICULTURAL OUTDOOR 

BUILDINGS/STRUCTURES, LAWNS AND TURF, ORNAMENTAL AND/OR SHADE TREES/GROUND 

COVER/HERBACEOUS PLANTS/NONFLOWERING PLANTS/WOODY SHRUBS AND VINES, PATHS/PATIOS, 

RESIDENTIAL LAWNS, ROSE

0.35 279-3348 F6570 EW PRO 

INSECTICIDE

BARNS, BATHROOM PREMISES/HARD SURFACES, COMMERCIAL/INDUSTRIAL LAWNS, COMMERCIAL

INDUSTRIAL PREMISES, COMMERCIAL TRANSPORTATION FACILITIES, DAIRY FARM MILK HANDLING 

FACILITIES/EQUIPMENT, DECIDUOUS FRUIT TREES, DRAINAGE SYSTEMS, EATING ESTABLISHMENTS, 

EGG PACKING PLANTS, FOOD PROCESSING PLANT PREMISES, GREENHOUSE-EMPTY, GREENHOUSES-IN 

USE, HOSPITALS/MEDICAL INSTITUTIONS HOUSEHOLD/DOMESTIC DWELLINGS , MEAT PROCESSING 

PLANT PREMISES , ORNAMENTAL AND/OR SHADE TREES/GROUND COVER/HERBACEOUS 

PLANTS/NONFLOWERING PLANTS/ORNAMENTAL WOODY SHRUBS AND VINES, PATHS/PATIOS, 

POULTRY PROCESSING PLANT, SOLID WASTE SITES, RESIDENTIAL LAWNS, TREE NUTS

0.04 279-3349 F6578 EW INSECTICIDE HOUSEHOLD/DOMESTIC DWELLINGS, ORNAMENTAL AND/OR SHADE TREES, ORNAMENTAL GROUND 

COVER, ORNAMENTAL HERBACEOUS PLANTS, ORNAMENTAL NONFLOWERING PLANTS, ORNAMENTAL 

WOODY SHRUBS AND VINES, PATHS/PATIOS, SOLID WASTE SITES, RESIDENTIAL LAWNS, ROSE

0.013 279-9534 F6129 EW INSECTICIDE GARDEN AND VEGETEABLES NONAGRICULTURAL FOOD CROPS, HOUSEHOLD/DOMESTIC DWELLINGS, 

ORNAMENTAL AND/OR SHADE TREES, RESIDENTIAL LAWNS

IMPREGNATED 

MATERIAL 

(IMPR)

10 39039-11 PYTHON MAGNUM 

INSECTICIDE CATTLE 

EAR TAGS

ANIMAL TREATMENT (EAR TAG)

10 39039-14 10 YT-1601 DOG TAG ANIMAL TREATMENT (COLLAR)

10 39039-4 PYTHON INSECTICIDE 

CATTLE EAR TAGS

ANIMAL TREATMENT (EAR TAG)

EMULSIFIABLE 

CONCENTRATE 

(EC)

0.75 1021-1859 EVERCIDE 28511 FOOD CROPS, ANIMAL KENNELS/SLEEPING QUARTERS, BARNS, COMMERCIAL INDUSTRIAL PREMISES,

COMMERCIAL STORAGES/WAREHOUSES PREMISES, DRAINAGE SYSTEMS, EATING ESTABLISHMENTS , 

EGGPLANT FOOD PROCESSING PLANT PREMISES, GREENHOUSES-IN USE, HOSPITALS/MEDICAL 

INSTITUTIONS (HUMAN/VETERINARY), HOUSEHOLD/DOMESTIC DWELLINGS, NONAGRICULTURAL 

OUTDOOR BUILDINGS/STRUCTURES, ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS 

PLANTS/NONFLOWERING PLANTS, PATHS/PATIOS, POULTRY FEEDLOTS, SOLID WASTE SITES,

ROSE, SWINE FEEDLOTS, LAWNS AND TURF

18.1 279-3125 FURY 1.5 EC INSECTICIDE FOOD CROPS

17.1 279-3126 FURY 1.5 EW INSECTICIDE FOOD CROPS

17.1 279-3243 ZETA-CYP EW AIRPORTS/LANDING FIELDS, BARNS, BATHROOM PREMISES/HARD SURFACES, 

COMMERCIAL/INDUSTRIAL PREMISES, COMMERCIAL STORAGES/WAREHOUSES, COMMERCIAL 

TRANSPORTATION FACILITIESDRAINAGE SYSTEMS, EATING ESTABLISHMENTS, FOOD PROCESSING 

PLANT PREMISES, GREENHOUSE-EMPTY, GREENHOUSES-IN USE, HOSPITALS/MEDICAL INSTITUTIONS 

(HUMAN/VETERINARY), HOUSEHOLD/DOMESTIC DWELLINGS, MULCH, NONAGRICULTURAL RIGHTSOF-WAY/FENCEROWS/HEDGEROWS, ORNAMENTAL AND/OR SHADE TREES/WOODY SHRUBS AND 

VINES, PATHS/PATIOS, SOLID WASTE SITES, RESIDENTIAL LAWNS, WOOD PROTECTION TREATMENT 

9.2 279-3248 Z-CYPE 0.8 EW 

INSECTICIDE

FOOD CROPS

9.6 279-3249 Z-CYPE 0.8 EC 

INSECTICIDE

FOOD CROPS, TERRESTIAL FEED

17.1 279-3289 ZETA-CYP 1.5EW OTC 

INSECTICIDE

HOUSEHOLD/DOMESTIC DWELLINGS OUTDOOR PREMISES, ORNAMENTAL WOODY SHRUBS AND VINES

3.75 279-3315 HERO INSECTICIDE FOOD CROPS, TERRESTIAL FEED

9.6 279-3327 ZETA-CYPE 0.8EC 

INSECTICIDE

FOOD CROPS, TERRESTIAL FEED/RENGELAND, ORNAMENTAL AND/OR SHADE TREES

ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/WOODY SHRUBS AND VINES

9.2 279-3328 ZETA-CYPE 0.8EC FOOD CROPS, TERRESTIAL FEED
27

INSECTICIDE

3.24 279-3329 F6126 EW INSECTICIDE FOOD CROPS, TERRESTIAL FEED

0.75 279-3362 F6138-1 ZW INSECTICIDE ANIMAL HOUSING PREMISES, ANIMAL KENNELS/SLEEPING QUARTERS, BARNS, COMMERCIAL/ 

INDUSTRIAL PREMISES/COMMERCIAL/ INDUSTRIAL PREMISES, COMMERCIAL STORAGES/ 

WAREHOUSES, DECIDUOUS FRUIT TREES, FOOD/GROCERY/MARKETING/STORAGE/DISTRIBUTION 

FACILITY PREMISES, HOUSEHOLD/DOMESTIC DWELLINGS, LIVESTOCK FEED LOTS, ORNAMENTAL 

AND/OR SHADE TREES/GROUND COVER/HERBACEOUS PLANTS/NONFLOWERING/ PLANTS/WOODY 

SHRUBS AND VINES, PATHS/PATIOS, RECREATIONAL AREAS, SOLID WASTE SITES , RESIDENTIAL 

LAWNS, TREE NUTS, UTILITIES, UTILITY POLES, RIGHT-OF-WAY

0.75 279-3363 F6138-1 ZW FHE 

INSECTICIDE

ANIMAL HOUSING PREMISES, ANIMAL KENNELS/SLEEPING QUARTERS, BARNS, 

COMMERCIAL/INDUSTRIAL PREMISES,COMMERCIAL STORAGES/WAREHOUSES, DECIDUOUS FRUIT 

TREES , FOOD STORES/MARKETS/SUPERMARKETS, HOUSEHOLD/DOMESTIC DWELLINGS, LIVESTOCK 

FEED LOTS, ORNAMENTAL AND/OR SHADE TREE/GROUND COVER/ HERBACEOUS PLANTS/ 

NONFLOWERING PLANTS/WOODY SHRUBS AND VINES, PATHS/PATIOS, RECREATIONAL AREAS

SOLID WASTE SITES (OUTDOOR), RESIDENTIAL LAWNS, TREE NUTS, UTILITIES, UTILITY POLES / RIGHTOF-WAY

8.2 279-3380 F9043 EC INSECTICIDE FOOD CROPS

9.6 279-3381 ZETA-CYPE 0.8 EC HSL 

INSECTICIDE

FOOD CROPS

9.15 279-3426 F9114 EC INSECTICIDE FOOD CROPS/TERRESTIAL FEED, ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/SOD 

FARM (TURF)/WOODY SHRUBS AND VINES

3.08 279-9545 F9047-2 EC INSECTICIDE AGRICULTURAL FOOD CROPS
Page 28 of 33

Attachment 4. International Residue Limit (IRL) Status

International Residue Limits 

Cypermethrin (PC Code 109702) and Zeta-Cypermethrin (PC Code 129064)

Summary of US and International Tolerances and Maximum Residue Limits 

Residue Definition:

US Canada Mexico Codex 1 2

40 CFR 180. 418(a)(1)

Plant/Livestock: cypermethrin 

(±)alpha cyano-(3-

phenoxyphenyl)methyl(±)cis,trans3(2,2-dichloroethenyl-2,2-

dimethylcyclopropanecarboxylate

(RS)-α-cyano-3-

phenoxybenzyl (1RS, 3RS)-

(1RS, 3SR)-

3-(2,2-dichlorovinyl)-2,2-

dimethylcyclopropanecarbo

xylate

cypermethrin (sum of 

isomers). The residue is 

fat-soluble.

Commodity Tolerance (ppm) /Maximum Residue Limit (mg/kg)

US Canada Mexico Codex 1 2

Brassica, head and stem, 

subgroup 5A

2.0 0.5 broccoli, Brussels 

sprouts, cabbages, 

cauliflower

1 Brassica (cole or 

cabbage) vegetables, 

head cabbage, 

flowerhead Brassicas

Brassica, leafy greens, 

subgroup 5B

14.0 0.7 leafy vegetables

Cattle, fat 1.0

Cattle, meat 0.2 2 meat (from mammals 

other than marine 

mammals) (fat) 4

Cattle, meat byproducts 0.05 0.05 (*) edible offal 

(mammalian) 4

Cotton, gin byproducts 11.0

Cotton, undelinted seed 0.5 0.1 oilseed

Egg 0.05 0.01 (*)

Goat, fat 1.0

Goat, meat 0.2 2 meat (from mammals 

other than marine 

mammals) (fat) 4

Goat, meat byproducts 0.05 0.05 (*) edible offal 

(mammalian) 4

Hog, fat 0.1

Hog, meat 0.05 2 meat (from mammals 

other than marine 

mammals) (fat) 4

Horse, fat 1.0

Horse, meat 0.2 2 meat (from mammals 

other than marine 

mammals) (fat) 4

Horse, meat byproducts 0.05 0.05 (*) edible offal 

(mammalian) 4

Lettuce, head 4.0 0.7 leafy vegetables

Milk, fat (reflecting 0.10 in 

whole milk)

2.5 0.5 milk fats

0.05 milk
Cypermethrin and Zeta-Cypermethrin Registration Review Scoping Document

Page 29 of 33

Summary of US and International Tolerances and Maximum Residue Limits 

Residue Definition:

US Canada Mexico Codex 1 2

Onion, bulb 0.1 0.1 dry bulb onions 0.01 (*)

Onion, green 6.0

Pecan 0.05

Poultry, fat 0.05

Poultry, meat 0.05 0.1 (fat)

Sheep, fat 1.0

Sheep, meat 0.2 2 meat (from mammals 

other than marine 

mammals) (fat) 4

Sheep, meat byproducts 0.05 0.05 (*) edible offal 

(mammalian) 4

180. 418 (a)(2)

Z-cypermethrin (S-cyano(3-

phenoxyphenyl) methyl 

(±))(cis-trans 3-(2,2-

dichloroethenyl)-2,2 

dimethylcyclopropanecarbox

ylate and its inactive Risomers

US Canada

Same as above

Mexico Codex 2

Same as above

3

Alfalfa, hay 15.0 30 alfalfa fodder

Alfalfa, forage 5.00

Alfalfa, seed 0.50

Almond, hulls 6

Animal feed, nongrass, group 

18, forage

8

Animal feed, nongrass, group 

18, hay

40

Beet, sugar, roots 0.05 0.1 sugar beet

Beet, sugar, tops 0.20

Berry group 13 0.8 0.2 strawberries 0.07 strawberry

Borage, seed 0.2 0.1 oilseed

Brassica, head and stem, 

subgroup 5A

2.00 0.5 broccoli, Brussels 

sprouts, cabbages, 

cauliflower

1 Brassica (cole or 

cabbage) vegetables, 

head cabbage, 

flowerhead Brassicas

Brassica, leafy greens, 

subgroup 5B

14.0 0.7 leafy vegetables

Cabbage 2.00

0.5

1 Brassica (cole or 

cabbage) vegetables, 

head cabbage, 

flowerhead Brassicas

Castor oil plant, refined oil 0.4 0.1 oilseed Castor oil plant, seed 0.2

Cattle, fat 1.00

Cattle, meat 0.2 2 meat (from mammals 

other than marine 

mammals) (fat) 4

Cattle, meat byproducts 0.05 0.05 (*) edible offal 

(mammalian) 4
Cypermethrin and Zeta-Cypermethrin Registration Review Scoping Document

Page 30 of 33

Summary of US and International Tolerances and Maximum Residue Limits 

Residue Definition:

US Canada Mexico Codex 1 2

Chinese tallowtree, refined 

oil

0.4

0.1 oilseed

Chinese tallowtree, seed 0.2

Cilantro, leaves 10

Citrus, dried pulp 1.8 2 citrus fruits Citrus, oil 4.0

Corn, field, forage 0.20

Corn, field, grain 0.05 0.3 cereal grains (except 

rice, barley, oats, rye 

and wheat C3

Corn, field, stover 3.00 10 straw and fodder 

(dry) of cereal grains

Corn, pop, grain 0.05

Corn, pop, stover 3.00 10 straw and fodder 

(dry) of cereal grains

Corn, sweet, forage 15.0

Corn, sweet, kernel plus cob 

with husks removed

0.05 0.05 (*)

Corn, sweet, stover 15.0 10 straw and fodder 

(dry) of cereal grains

Cotton, undelinted seed 0.5

0.1 oilseed Crambe, seed 0.2

Cuphea, seed 0.2

Echium, seed 0.2

Egg 0.05 0.01 (*)

Euphorbia, refined oil 0.4

0.1 oilseed Euphorbia, seed 0.2

Evening primrose, refined oil 0.4

Evening primrose, seed 0.2

Flax, seed 0.2

Food commodities/feed 

commodities (other than 

those covered by a higher 

tolerance as a result of use on 

growing crops) in food/feed 

handling establishments

0.05

Fruit, citrus, group 10 0.35 1.0 citrus fruits 2 citrus fruits

Fruit, pome, group 11 2 1.0 apples

0.5 pears 0.7 pome fruits

Fruit, stone, group 12 1 0.2 peaches/nectarines 2 stone fruits

Goat, fat 1.00

Goat, meat 0.2 2 meat (from mammals 

other than marine 

mammals) (fat) 4

Goat, meat byproducts 0.05 0.05 (*) edible offal 

(mammalian) 4

Gold of pleasure, seed 0.2 0.1 oilseed

Grain, aspirated fractions 10.0
Cypermethrin and Zeta-Cypermethrin Registration Review Scoping Document

Page 31 of 33

Summary of US and International Tolerances and Maximum Residue Limits 

Residue Definition:

US Canada Mexico Codex 1 2

Grape 2

0.5 

0.2 

0.5 dried grapes 

(=currants, raisins and 

sultanas)

Grass, forage, fodder, and 

hay, group 17, forage

10

Grass, forage, fodder and 

hay, group 17, hay

35 10 straw and fodder 

(dry) of cereal grains

Hare's-ear mustard, seed 0.2 0.1 oilseed

Hog, fat 0.1

Hog, meat 0.05 2 meat (from mammals 

other than marine 

mammals) (fat) 4

Horse, fat 1.00

Horse, meat 0.2 2 meat (from mammals 

other than marine 

mammals) (fat) 4

Horse, meat byproducts 0.05 0.05 (*) edible offal 

(mammalian) 4

Jojoba, refined oil 0.4

0.1 oilseed

Jojoba, seed 0.2

Lesquerella, seed 0.2

Lunaria, seed 0.2

Meadowfoam, seed 0.2

Milk, fat (reflecting 0.10 in 

whole milk)

2.50 0.5 milk fats

0.05 milks4

Milkweed, seed 0.2

0.1 oilseed Mustard, seed 0.2

Niger seed, refined oil 0.4

Niger seed, seed 0.2

Nut, tree, group 14 0.05

Oil radish, seed 0.2 0.1 oilseed

Okra 0.2 0.5

Onion, bulb 0.10 0.1 dry bulb onions 0.01 (*)

Onion, green 3.00

Pea and bean, dried shelled, 

except soybean, subgroup 6C

0.05 0.5 beans 0.05 (*) pulses

Pea and bean, succulent 

shelled, subgroup 6B

0.1 0.5 beans 0.7 legume vegetables

Peanut 0.05

Pecan 0.05

Poppy, seed 0.2 0.1 oilseed

Poultry, fat 0.05

Poultry, meat 0.05 0.1 (fat)

Rapeseed 0.2 0.1 oilseed

Rice, grain 1.50 2 rice

Rice, hulls 6.00

Rice, straw 2.00 10 straw and fodder 

(dry) of cereal grains

Rice, wild, grain 1.5
Cypermethrin and Zeta-Cypermethrin Registration Review Scoping Document

Page 32 of 33

Summary of US and International Tolerances and Maximum Residue Limits 

Residue Definition:

US Canada Mexico Codex 1 2

Rose hip, refined oil 0.4

Rose hip, seed 0.2 0.1 oilseed

Safflower, seed 0.2

Sesame, seed 0.2

Sheep, fat 1.00

Sheep, meat 0.2 2 meat (from mammals 

other than marine 

mammals) (fat) 4

Sheep, meat byproducts 0.05 0.05 (*) edible offal 

(mammalian) 4

Sorghum, grain, forage 0.1

Sorghum, grain, grain 0.5 0.3 cereal grains (except 

rice, barley, oats, rye 

and wheat Acz3

Sorghum, grain, stover 5.0 10 straw and fodder 

(dry) of cereal grains

Soybean, seed 0.05 0.05 (*) pulses

Stokes aster, refined oil 0.4 0.1 oilseed Stokes aster, seed 0.2

Sugarcane, cane 0.60 0.2 sugar cane

Sunflower, refined oil 0.5

0.1 oilseed

Sunflower, seed 0.2

Sweet rocket, seed 0.2

Tallowwood, refined oil 0.4

Tallowwood, seed 0.2

Tea oil plant, refined oil 0.4

Tea oil plant, seed 0.2

Turnip, greens 14

Vegetable, cucurbit, group 9 0.2 0.07 Fruiting vegetables, 

cucurbits

Vegetable, fruiting, group 8 0.2

0.3 tomatoes

0.03 eggplant

0.5 okra

2 peppers chili

10 peppers chili, dried

0.1 peppers, sweet 

(including pimento or 

pimiento)

0.2 tomato

Vegetable, leafy, except 

brassica, group 4

10.0 1.0 celery 0.7 leafy vegetables

Vegetable, legume, edible 

podded, subgroup 6A

0.5 0.5 beans 0.7 legume vegetables

Vegetable, root and tuber, 

group 1, except sugar beet

0.1 0.01 (*) root and tuber 

vegetables (Except 

sugar beet)

Vernonia, refined oil 0.4 0.1 oilseed Vernonia, seed 0.2

Wheat, forage 3.0

Wheat, grain 0.2 2 Po C

5 wheat bran, 

unprocessed PoP C

3

3
Cypermethrin and Zeta-Cypermethrin Registration Review Scoping Document

Page 33 of 33

Summary of US and International Tolerances and Maximum Residue Limits 

Residue Definition:

US Canada Mexico Codex 1 2

Wheat, hay 6.0 10 straw and fodder 

Wheat, straw 7.0 (dry) of cereal grains

MRLs with NO US equivalent

Artichoke, globe 0.1

Asparagus 0.01 (*) (proposed)

Barley 2 Po C3

Bean fodder 2 C3

Carambola 0.2

Coffee beans 0.05 (*)

Durian 1

Leek 0.05

Litchi 2

Longan 1

Mango 0.7

Oats 2 Po C3

Olives 0.05 (*)

Olive oil, refined 0.5

Olive oil, virgin 0.5

Papaya 0.5

Pea hay or pea fodder (dry) 2

Poultry, edible offal of 0.05 (*)

Rye 2 Po C3

Tea, green, black (black, 

fermented and dried) 20 

Completed: M. Negussie; 01/17/2012 1 Mexico adopts US tolerances and/or Codex MRLs for its export purposes.

2 * = absent at the limit of quantitation; Po = postharvest treatment, such as treatment of stored grains. PoP = 

processed postharvest treated commodity, such as processing of treated stored wheat. (fat) = to be measured on the 

fat portion of the sample. MRLs indicated as proposed have not been finalized by the CCPR and the CAC.

3 Source of data supporting the proposed MRL: a-alpha-cypermethrin; c-cypermethrin; z- zeta -cypermethrin; 

Capital letters show the source of data responsible for the MRL estimate.

4 The MRL accommodates external treatment