Docket Number: EPA-HQ-OPP-2010-0453 www.regulations.gov

United States Chemical Safety September 2010

Environmental Protection and Pollution Prevention Agency (7510P)



# Terbuthylazine Summary Document: Registration ReviewDocket Number: EPA-HQ-OPP-2010-0453 www.regulations.gov



### TABLE OF CONTENTS

Terbuthylazine Registration Review Team .................................................................... 4

I. PRELIMINARY WORK PLAN – TERBUTHYLAZINE ........................................ 5

II. FACT SHEET ............................................................................................................ 13

III. GLOSSARY of TERMS & ABBREVIATIONS ................................................... 16 IV. Appendix A ................................................................................................................ 18

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Terbuthylazine Regist ration Review Team

Human Health & Environmental Effects

Nathan Mottl Najm Shamim

Risk Management

Eliza Blair

Lance Wormell

Office of General Counsel Philip Ross

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I. PRELIMINARY WORK PLAN – TERBUTHYLAZINE

Introduction

The Food Quality Protection Act (FQPA) of 1996 mandated a re gistration review program. All pesticides distributed or sold in the United States generally must be registered by the U.S. Environmental Protec tion Agency (USEPA, EPA, or the Agency), based on scientific data showing that they will not cause unreasonable risks to human

health or the environment when used as di rected on product labe ling. The registration review program is intended to make sure that , as the ability to assess risk evolves and as policies and practices change, all registered pesticides continue to meet the statutory

standard of no unreasonable adverse effects to human health or the environment. Changes in science, public policy, and pestic ide use practices will occur over time. Through the registration review program, the Agency periodically r eevaluates pesticides to make sure that as change occurs, products in the marketplace can be used safely. Information on this program is provided at http://www.epa.gov/oppsrr d1/registration_review/

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The Agency is implementing the registration review program pursuant to Section 3(g) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review each registered pesticide every 15 years to de termine whether it continues to meet the FIFRA standard for registration. The Agency will consider benefits information and data as required by FIFRA. The public phase of re gistration review begins when the initial docket is opened for each case. The docket is the Agency’s opportunity to state what it knows about the pesticide and what additional risk analyses and data or information it believes are needed to make a registrati on review decision. After reviewing and responding to comments and data received in the docket during th is initial comment period, the Agency will develop and commit to a final work plan and schedule for the registration review of terbuthylazine.

Terbuthylazine, first register ed as an herbicide in 1975, is now registered for use solely as a slimicide in industrial recirculat ing cooling water applic ations and ornamental fountains. There are four registered products . A Reregistration Eligibility Decision (RED) for Terbuthylazine was issued by EPA in 1995. The RED can be located at http://www.epa.gov/pesticides/reregistration/status.htm

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Risk Assessment Status & Anticipated Data Needs

Human Health Risk Assessment Status and Anticipated Data Needs

The Agency has reviewed all the availa ble information on toxicology and human exposure regarding terbuthylazin e and does not anticipate that additional data will be needed for this registration review case. If the results from the environmental fate data (see below) indicate that terbuthylazine has the pote ntial to pass through wastewater treatment plants and into drinking water, the need for a drinking water assessment will be

revisited.

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Further information is available in “Terbuthylazine: Human Health Effects Scoping Document for the Registration R eview Decision”, dated July 19, 2010.

Dietary and Drinking Water Assessment

The need for a drinking water exposur e assessment will be revisited upon submission and review of the environmental fate data the Agency anticipates requiring through Registration Review. These environmenta l fate data will be us ed to determine if terbuthylazine has the potential to pass th rough wastewater treatment facilities into drinking water or migrate into residential gr oundwater wells as a resu lt of its current use

patterns.

Tolerances

There are no current tolerances or exemptions from tolerances for the terbuthylazine active ingredient and no registered food uses.

Aggregate/Cumulative Exposure & Risk

In examining aggregate exposure, EP A takes into account the available and reliable information concerning exposures to pesticide residues in food and drinking water, as well as non-occupationa l pesticide exposures. Base d on current use patterns, an aggregate risk assessment will not be needed for terbuthylazine. Residential exposure is not expected and the need for a drinking water exposure assessment will be determined upon submission and review of the environmen tal fate data the Agency anticipates requiring.

Section 40(b)(2)(D)(v) of FFDCA require s that, when considering whether to establish, modify, or revoke a tolerance, th e Agency considers “available information” concerning the cumulative effects of a part icular pesticide’s residues and “other

substances that have a common mechanism of toxicity.” EPA has not yet determined whether terbuthylazine has a common m echanism with other compounds, however, during the risk assessment stage for regist ration review, the Agency will address the possibility that terbuthylazi ne shares a common mechanis m of toxicity with other

members of the Triazine Common Mechanis m Group (CMG) and whether terbuthylazine should be included in a cumulative exposure gr oup with the rest of the triazines.

The Agency examined the triazine class of pesticides with respect to a potential common mechanism of toxicity. Th is examination may be found at http://www.epa.gov/oppsrrd1/cumulativ e/triazines/triazinescommonmech.pdf . Several

members of this class have been identif ied as causing toxici ty through a similar mechanism of action. Specifically, atrazine, simazine, propazine, and certain degradates are considered to act through disruption of the hypothalamic- pituitary-gonadal axis to attenuate the luteinizing hormone surge. As a result of th is attenuation, exposure of the animal to estrogen is continuous, prov iding an environment conducive to the development of mammary gland tumors. Mamma ry gland tumors have been observed in

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female rats after administration of these chemicals, and the postulated mode of action of the triazine pesticide atrazine has been revi ewed by the FIFRA Scientific Advisory Panel and has been found to be pl ausible (U.S. EPA, 2000).

Occupational and Resi dential Assessment

An occupational and/or residential expos ure assessment is required for an active ingredient if (1) certain toxico logical criteria are triggered and (2) there is potential exposure to handlers (mixers, loaders, applicators, etc.) during use.

Currently application to recirculati ng cooling water systems and ornamental fountains is required by the label to be thr ough closed-system only. In the event that the product needs to be handled, personal protectiv e equipment is required by the label in the form of a long-sleeved shirt, long pants, shoe s, socks, chemical-resistant gloves, and the availability of a chemical-resistant apron fo r spills. As a result, the Agency does not anticipate the need to conduct occupational and residential ha ndler dermal and inhalation risk assessments since exposure is minimized by the required engineer ing controls as well as the required personal protectiv e equipment. At this time, the Agency anticipates that no exposure data will be needed.

Anticipated Human Health Data Needs:

All human toxicology and exposure data requirements have been fulfilled for the active ingredient terbuthylazine. The Agen cy has reviewed the available data for terbuthylazine and expects that no additional toxicity or exposure data will be needed for registration review.

Further information is available in “Summary of Human Health Effects Data for the Terbuthylazine Registration Review Decision Document”, dated July 19, 2010.

Anticipated Physical/ Chemic al Property Data Needs

All product chemistry data requirements have been fulfilled for the active ingredient terbuthylazine. Ther efore, the Agency does not an ticipate needing additional product chemistry data at this time.

Further information is available in “Terbuthylazine: Product Chemistry / Environmental Fate and Eco-Effects Scoping Document”, dated July 28, 2010 .

Anticipated Environmental Fate and Ecotoxi city Risk Assessment and Data Needs

The Agency has reviewed the environmental fate and ecological hazard databases for terbuthylazine. Based on its review, EP A believes the following environmental fate and ecological hazard risk assessments are need ed to ensure that the registration review

case meets FIFRA standards:

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• Environmental fate

• Ecological hazard

• Endangered species assessment

Further information and detailed justificat ions for the studies that are anticipated as being needed are available in “Terbut hylazine: Product Chemis try / Environmental Fate and Eco-Effects Scoping Document”, dated July 28, 2010 .

The Agency expects that it will need to conduct environmental fate and ecological risk assessments for slimicides that potent ially pass through waste water treatment plants (WWTPs) and may be discharged into te rrestrial and aquati c environments.

Anticipated Environmental Fate Data Needs:

o (GLN 835.3110) Ready Biodegradability

o (GLN 835.1110) Activated Sludge Isotherm

Anticipated Ecological Effects Data Needs:

o (GLN 850.5400) Aquatic plant growth (algal), Tier II

Endangered Species

The Agency has not conducted a risk assessment that supports a complete endangered species determination for terbut hylazine. The ecological risk assessment planned during registration review will a llow the Agency to determine whether terbuthylazine use has “no effect” or “may affect” federally listed threatened or endangered species (listed species) or their designated critical habitats. When an assessment concludes that a pesticide’s use “may affect” a listed species or its designated critical habitat, the Agency will consult with the U.S. Fish and Wildlife Service and/or

National Marine Fisheries Services (the Services), as appropriate.

Incidents:

A search of OPP’s Incident Database System (IDS) revealed two incidents associated with terbuthylazine. No furthe r information was available regarding these

incidents.

Timeline:

The Agency has created the following estimated timeline for the completion of the terbuthylazine registration review:

Activities Estimated Month/Year

Phase 1: Opening the docket
Open Public Comment Period for Ter buthylazine Docket September 2010

Close Public Comment Period November 2010

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Phase 2: Case Development

Develop Final Work Plan (FWP) February 2011

Issue DCI February 2012

Data Submission February 2014
Open Public Comment Period for Preliminary Risk Assessments September 2015

Close Public Comment Period December 2015

Phase 3: Registration Review Decision
Open Public Comment Period for Proposed Reg. Review Decision March 2016

Close Public Comment Period June 2016 Final Decision and Begin Post-Decision Follow-up 2016 Total (years) 6

Guidance for Commenters:

The public is invited to co mment on EPA’s preliminary registration review workplan and rationale. The Agency will consider all comments as well as any additional information or data provided in a timely manne r prior to issuing a fi nal work plan for the terbuthylazine case.

Trade Irritants

Through the registration review process, th e Agency intends to solicit information on trade irritants and, to the extent feasible , take steps toward facilitating irritant

resolution. Growers and other stakeholders are asked to comment on any trade irritant issues resulting from lack of Maximum Residue Limits (MRLs) or disparities between U.S. tolerances and MRLs in key export ma rkets, providing as much specificity as possible regarding the nature of the concern.

Water Quality

Terbuthylazine are not identif ied as a cause of impairment for any water bodies listed as impaired under sect ion 303(d) of the Clean Water Act, based on information provided at http://iaspub.epa.gov/tmdl_waters10/attain s_nation_cy.cause_detail_303d?p_cause_grou p_id=885 . In addition, no Total Maximum Daily Loads (TMDL) have been developed for [insert pesticide], based on information provided at http://iaspub.epa.gov/tmdl_waters10/attain s_nation.tmdl_pollutant _detail?p_pollutant_gr oup_id=885&p_pollutant_group_name=PESTICIDES . More information on impaired

water bodies and TMDLs can be found at http://www.epa.gov/owow/tmdl/ . The Agency invites submission of water quality data for this pesticide. To the extent possible, data should conform to the quality standards in Appendix A of the OPP Standard Operating Procedure: Inclusion of Im paired Water Body and Other Water Quality Data in OPP’s Registration Review Risk A ssessment and Management Process (see:

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http://www.epa.gov/oppsrrd1/regist ration_review/water_quality_sop.htm ), in order to ensure they can be used quantitatively or qualitatively in pesticide risk assessments.

Environmental Justice

EPA seeks to achieve environmental justi ce, the fair treatment and meaningful involvement of all people, regardless of race, color, national origin, or income, in the development, implementation, and enforcemen t of environmental laws, regulations, and policies. To help address potential envir onmental justice issues, the Agency seeks information on any groups or segments of the population who, as a result of their location, cultural practices, or other factor s, may have atypical, unusually high exposure to terbuthylazine, compared to the genera l population. Please comment if you are aware of any sub-populations that may have atypical , unusually high exposure compared to the general population.

Structure Activity Relationships

EPA must rely upon information of appropr iate quality and reliability for each decision made by the Agency. In the Office of Pesticide Programs (OPP), the evaluation process for a pesticide chemical traditionally begins with the appli cant’s submission of a

set of studies conducted with th e specific pesticide chemical of interest. The use of the results of such testing (measured data) is a logical, scientifically rigorous process that identifies the physical, chemical, and environmen tal fate properties of the pesticide, as well as the dose and endpoints at which an adverse effect can occur in various animal species.

Today, there is significant interest in a lternative techniques, i.e., techniques other than data generation that could significantly inform the Agency’s decision-making process. Recently, OPP has made increasing use of structure activity relationship (SAR) as part of its regulatory d ecision-making process. In the SAR process, a chemical's molecular structure is compared to that of other chemicals fo r which data are available.

These structural similarities are then us ed to make predictive judgments about a chemical’s physical, chemical, and biological properties. Thus, the chemical’s physical, chemical, and biological propertie s are a function of (o r directly related to) the chemical’s molecular structure. Quantitative SAR is re ferred to as QSAR. To develop a QSAR, a selected set of measured data on a single phys ical, chemical, or bi ological property is used to derive a model (an equation) to predict the value of that property.

Since SAR assessments and QSAR modeli ng are another set of tools that are available to Agency scientists, OPP has begun a process shift that envisions shifting from the current study-by-study appro ach to an approach in which the use of predicted data, generated using validated models, is cons idered along with information from open literature and studies specifi cally generated under Part 161 requirements. All relevant information would be considered as part of a weight-of-the-evidence evaluation.

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At this time, EPA believes that for cert ain endpoints, especially physical/chemical and fate properties, that SAR and QSAR might be effectively utilized to fulfill these data requirements for many antimicrobial pesticide chemicals. When c onsidering biological properties, at this time, EPA believes that SAR and QSAR can be most effectively

utilized in the evaluation of ch emicals that exhibit lower toxi city for human health and/or ecotoxicity parameters. This is appropriate because the risk assessment for lower toxicity chemicals can be stream-lined, i.e., a screen ing-level assessment pr ocedure rather than multiple tiers of assessments with pr ogressively more data requirements.

If stakeholders believe that submission of predicted data can fulfill one of the data needs for terbuthylazine, then the Agency invites submission of this information. The submitter would be expected to supply a rationa le describing the utility of the information and provide documentation on the scientif ic validity of the information. The determination that the predicted data fulfills the data requirement would be at the sole discretion of the Agency. Pre-submission c onsultation with the Agency is encouraged.

Endocrine Disruptor Screening Program

As required under FFDCA section 408(p) , EPA has developed the Endocrine Disruptor Screening Program (EDSP) to dete rmine whether certain substances (including pesticide active and other ingred ients) may have an effect in humans or wildlife similar to an effect produced by a “natur ally occurring estrogen, or othe r such endocrine effects as the Administrator may designate.” The ED SP employs a two-tiered approach to making the statutorily required determinations. Tier 1 consists of a battery of 11 screening assays to identify the potential of a chemical substa nce to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal systems. Chemicals that go through Tier 1 screening and are found to have the potential to inte ract with E, A, or T hormonal systems will proceed to the next stage of the EDSP wher e EPA will determine which, if any, of the Tier 2 tests are necessary based on the avai lable data. Tier 2 te sting is designed to identify any adverse endocrine related eff ects caused by the substance, and establish a dose-response relationship between th e dose and the E, A, or T effect.

Between October 2009 and February 2010, EPA issued test orders/data call-ins for the first group of 67 chemicals, which c ontains 58 pesticide ac tive ingredients and 9 inert ingredients. This list of chemicals was selected based on the potential for human exposure through pathways such as food and wa ter, residential activity, and certain postapplication agricultural s cenarios. This list should not be construed as a list of known or likely endocrine disruptors.

Terbuthylazine is not among the group of 58 pesticide active ingredients on the

initial list to be screened under the EDSP. Under FFDCA sec. 408(p) the Agency must screen all pesticide chemicals. Accordingl y, EPA anticipates issuing future EDSP test orders/data call-ins for Registration Review cases, including those for which EPA has already opened a Registration Review docke t for a pesticide active ingredient.

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For further information on the status of the EDSP, the policies and procedures, the list of 67 chemicals, the test guidelines and the Tier 1 screening battery, please visit our

website: http://www.epa.gov/endo/

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Additional Information

Stakeholders are also specifically asked to provide available information and data that will assist the Agency in refining the ecological and human health risk assessments. The Agency is interested in obtaining the following information regarding the use of terbuthylazine:

1. Confirmation on the following label information:

a. Sites of application

b. Formulations

c. Application methods and equipment

d. Maximum application rates

e. Frequency of application, app lication intervals and maximum number of applications

f. Geographic limitations on use

2. Use or potential use distribution

3. Use history

4. Usage/use information for non-agricultural uses (e.g., materials preservation)

5. Typical application interval

6. State or local use restrictions

7. Ecological incidents (non-target plant damage and avian, fish, reptilian, amphibian and mammalian mo rtalities) not already reported to the Agency

8. Monitoring data

9. Structure Activity Relationships

Next Steps:

After the 60-day comment period closes, th e Agency will review and respond to any comments received in a timely manner, a nd then issue a Final Work Plan for terbuthylazine.

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II. FACT SHEET

Background Information

• Chemical Name: terbuthylazine

• Registration review case number: 2645

• PC Code: 080814

• CAS#: 5915-41-3

• Technical registrant: BWA Water Additives

• First approved for use in a registered product: 1975

• RED issued in 1995

• Four registered products contain terb uthylazine as an active ingredient

• Antimicrobials Division Chemical Revi ew Manager (CRM): Eliza Blair, blair.eliza@epa.gov

• Antimicrobial Division Product Manager: Marshall Swindell, swindell.marshall@epa.gov

Chemical Structure:

Use & Usage Information

• First registered as an herbicide for us e on corn fodder and forage, corn grain (popcorn grain included), sorghum forage and grain; food-use tolerances were

established for these use sites and then revoked in 1992 when these uses were

canceled.

• Now registered for use solely in industri al recirculating cool ing water systems and

ornamental fountains.

• Personal protective equipment required by th e label in the event the product needs to be handled include a long-sleeved shirt, long pants, socks and shoes, chemicalresistant gloves, and the availability of a chemical-resistant apron in the event of a spill.

• Application of currently-regis tered products is restricted to closed-system loading. Open pouring is prohibited.

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Recent Regulatory Actions

There have been no recent regulato ry actions regarding the chemical terbuthylazine.

Human Health Risk Assessment Status

The Agency has reviewed the human health exposure and toxicity database for the terbuthylazine case and anticipates that no additional exposure and toxicity data will be needed for registration review.

Further information is available in Furt her information is available in Summary of Human Health Effects Data for the Te rbuthylazine Registration Review Decision Document, dated July 19, 2010.

Product Chemistry Database Status

The Agency has reviewed the product chem istry database for the terbuthylazine registration review case and an ticipates that no additional product chemistry data will be needed for registration review.

Further information and is available in “Terbuthylazine: Product Chemistry / Environmental Fate and Eco-Effects Scoping Document”, dated July 28, 2010 .

Environmental Fate & Ecologi cal Risk Assessment Status

The Agency has reviewed the environmen tal fate and ecotoxicity databases for the terbuthylazine case and anticipates needing additional environmental fate and ecotoxicity data for the registrati on review of this chemical.

The Agency has not conducted a risk assessment that supports a complete endangered species determination for terbut hylazine. The ecological risk assessment planned during registration review will a llow the Agency to determine whether terbuthylazine use has “no effect” or “may affect” federally listed threatened or endangered species (listed species) or their designated critical habitats. When an assessment concludes that a pesticide’s use “may affect” a listed species or its designated critical habitat, the Agency will consult with the U.S. Fish and Wildlife Service and/or

National Marine Fisheries Services (the Services), as appropriate.

Further information and detailed justificat ions for the studies that are anticipated as being needed are available in “Terbut hylazine: Product Chemis try / Environmental Fate and Eco-Effects Scoping Document”, dated July 28, 2010 .

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Tolerances

There are no current tolerances or exemptions from tolerances for the terbuthylazine active ingredient and no registered food uses.

Data Call-In Status

A RED was issued for terbuthylazine in 1995. A Generic Data Call-In (GDCI) was issued in 1995 (data requirements sati sfied). A Product-Sp ecific Data Call-In (PDCI) was also issued in 1995 (data requireme nts satisfied). The Agency anticipates needing additional data to complete a risk assessment during Registration Review.

Labels

There are four products registered for terbuthylazine. The EPA Registration Number is provided in Table 1 below. Produc t registration labels may be obtained from the Pesticide Product Label System (PPLS) website at: http://oaspub.epa.gov/pestlabl/ppls.home

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Table 1. Registered products containing Terbuthylazine

EPA Reg.

No. Product Name Formulation Type Percent Active Ingredient Registrant

83451-7 Bellacide 320 MUP 96 BWA Water Additives US,

LLC

9386-34 AMA-204 Aqueous Dispersion 4.0 Kemira Chemicals, Inc

83451-8 Bellacide 329 Aqueous Dispersion 44.7 BWA Water Additives US,

LLC

83451-9 Bellacide 325 Aqueous Dispersion 4.0 BWA Water Additives US,

LLC

Incidents

A search of OPP’s Incident Database System (IDS) revealed two incidents connected to terbuthylazine. No further information was available regarding these

incidents.

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III. GLOSSARY of TERMS & ABBREVIATIONS

ai Active Ingredient AR Anticipated Residue ASTM American Society for Testing and Materials

AWPA American Wood Preserver’s Association

CFR Code of Federal Regulations cPAD Chronic Population Adjusted Dose

CSF Confidential Statement of Formula CSFII USDA Continuing Surveys for Food Intake by Individuals

DCI Data Call-In DEEM Dietary Exposure Evaluation Model DFR Dislodgeable Foliar Residue DNT Developmental Neurotoxicity DWLOC Drinking Water Level of Comparison

EC Emulsifiable Concentrate Formulation EDWC Estimated Drinking Water Concentration

EEC Estimated Environmental Concentration EPA Environmental Protection Agency

EUP End-Use Product FDA Food and Drug Administration FIFRA Federal Insecticide, Fungicide, and Rodenticide Act FFDCA Federal Food, Drug, and Cosmetic Act FQPA Food Quality Protection Act FOB Functional Observation Battery GENEEC Tier I Surface Water Computer Model

IR Index Reservoir

LC 50 Median Lethal Concentration. A statistically derived concentration of a substance that can be expected to cause death in 50% of test animals. It is usually expressed as the weight of substance per weight or volume of water, air or feed, e.g., mg/l, mg/kg or ppm.

LD 50 Median Lethal Dose. A statistically deri ved single dose that can be expected to

cause death in 50% of the test animals when administered by the route indicated (oral, dermal, inhalation). It is expressed as a weight of substance per unit weight of animal, e.g., mg/kg.

LOC Level of Concern

LOAEL Lowest Observed Adverse Effect Level μg/g Micrograms Per Gram μg/L Micrograms Per Liter mg/kg/day Milligram Per Kilogram Per Day mg/L Milligrams Per Liter MOE Margin of Exposure

MRID Master Record Identifi cation (number). EPA's system of recording and tracking

submitted studies. MUP Manufacturing-Use Product

NA Not Applicable NAWQA USGS National Ambient Water Quality Assessment NPDES National Pollutant Discharge Elimination System

NR Not Required

NOAEL No Observed Adverse Effect Level

OPP EPA Office of Pesticide Programs OPPTS EPA Office of Prevention, Pesticides and Toxic Substances PAD Population Adjusted Dose PAIRA Pure Active Ingredient Radiolabelled PCA Percent Crop Area

PDP USDA Pesticide Data Program

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17 of 21 PHED Pesticide Handler's Exposure Data

PHI Preharvest Interval ppb Parts Per Billion

PPE Personal Protective Equipment

ppm Parts Per Million PRZM/EXAMS Tier II Surface Water Computer Model Q 1 * The Carcinogenic Potential of a Compound, Quantified by the EPA's Cancer

Risk Model RAC Raw Agriculture Commodity RED Reregistration Eligibility Decision

REI Restricted Entry Interval

RfD Reference Dose RQ Risk Quotient SCI-GROW Tier I Ground Water Computer Model

SAP Science Advisory Panel SF Safety Factor

SLN Special Local Need (Registrati ons Under Section 24©) of FIFRA) TGAI Technical Grade Active Ingredient

TEP Typical End-Use Product USDA United States Department of Agriculture UF Uncertainty Factor

WPS Worker Protection StandardDocket Number: EPA-HQ-OPP-2010-0453www.regulations.govIV.Appendix AUse SiteFormulationMethod ofApplicationApplication Rate/ No. ofapplicationsUse LimitationsIndustrial processes and water systemOpsIndustrial recirculationwater cooling systemsSolubleConcentrate:83451-883451-9Technical:83451-7Ready-to-UseSolution:9386-34IncorporationContinuousfeed methodIntermittent orSlug methodContinuousfeed methodChlorinated and/orBrominated Systems(i) Continuous Addition:Maintain up to 2.5 fluid oz/ 10,000 gallons of water(~2 ppm)(ii) Slug/Intermittentaddition: maintain up to 2ppm concentration.Non-Chlorinated and/orBrominated systems, bothcontinuous andslug/intermittent doseMaintain up to 8 fluid oz. /10,000 gallons of water(~6.7 ppm)Chlorinated and/orBrominated systems(i) Continuous Addition:maintain up to 3 fluid oz. /Open pouring of this product is prohibited.Mixing, loading, and application must be witha closed system (one that prevents thechemical from contacting handlers or otherpersons) and during handling of the chemicalpersonal protective equipment must be worn.Personal protective equipment includes longsleeved shirt, long pants, shoes, socks, andchemical-resistant gloves. A chemicalresistant apron must beimmediately availableduring loading and application and must beworn in case of a leak, spill, or other exposureto the concentrate.Do not use in cooling systems or fountainswhere the treated water will come into contactwith lawns, trees, shrubs or other desirableplants. Water from treated systems may notbe used for irrigationor spraying of plants,nor for watering livestock, nor for humanconsumption.18 of 21Docket Number: EPA-HQ-OPP-2010-0453www.regulations.govUse Site Formulation Method ofApplicationApplication Rate/ No. ofapplicationsUse LimitationsIntermittent orSlug method1,000 gallons of water (~25ppm)(ii) Slug/IntermittentAddition: Apply sufficientproduct to maintain up to25 ppm of product insystem waterNon-Chlorinated and/orBrominated systemsMaintain up to 9 fluid oz. /1,000 gallons of water (~75ppm) via continuous orslug/intermittent dosing asdescribed above.19 of 21Docket Number: EPA-HQ-OPP-2010-0453www.regulations.govDecorative/Ornamental Fountains (Indoor)Ornamental fountainsSolubleConcentrate:83451-883451-9Technical:83451-7Ready-to-UseSolution:9386-34IncorporationContinuousfeed methodIntermittent orSlug methodChlorinated and/orBrominated Systems(i) Continuous Addition:Maintain up to 2.5 fluid oz/ 10,000 gallons of water(~2 ppm)(ii) Slug/Intermittentaddition: maintain up to 2ppm concentration.Non-Chlorinated and/orBrominated systems, bothcontinuous andslug/intermittent doseMaintain up to 8 fluid oz. /10,000 gallons of water(~6.7 ppm)Chlorinated and/orBrominated systems(i) Continuous Addition:maintain up to 3 fluid oz. /1,000 gallons of water (~25ppm)(ii) Slug/IntermittentOpen pouring of this product is prohibited.Mixing, loading, and application must be witha closed system (one that prevents thechemical from contacting handlers or otherpersons) and during handling of the chemicalpersonal protective equipment must be worn.Personal protective equipment includes longsleeved shirt, long pants, shoes, socks, andchemical-resistant gloves. A chemicalresistant apron must beimmediately availableduring loading and application and must beworn in case of a leak, spill, or other exposureto the concentrate.Do not use in cooling systems or fountainswhere the treated water will come into contactwith lawns, trees, shrubs or other desirableplants. Water from treated systems may notbe used for irrigationor spraying of plants,nor for watering livestock, nor for humanconsumption.20 of 21Docket Number: EPA-HQ-OPP-2010-0453www.regulations.gov21 of 21Addition: Apply sufficientproduct to maintain up to25 ppm of product insystem waterNon-Chlorinated and/orBrominated systemsMaintain up to 9 fluid oz. /1,000 gallons of water (~75ppm) via continuous orslug/intermittent dosing asdescribed above.