### 2 Executive Summary
The Health Effects Division Cy permethrin Risk Assessment T eam has evaluated the database and the most recent human health risk assessments for the insecticides cypermethrin and zeta

cy permethrin

. HED performed th is evaluation in order to determine the scope of work necessary to support the established tolerances and existing registrations. The primary source s of information for this evaluation w ere recent human health risk assessment s written for the chemical s
. Cypermethrin and zeta

- cypermethrin products are registered for use on a wide variety of agricultural and residential sites and are formulated as a wide variety of end use products with up to 40% of active ingredient. In residential settings, the cypermethrins are applied using common hand

- held equipment and ready

- to

- use devices. On the various agricultural crops, up to 8 applications may be made per season using common agricultural equipment.
The synthetic pyrethroid insecticide c ypermethrin [(±) α

- cyano
- (3

- phenoxyphenyl)methyl (±

- cis , trans

- 3

- (2,2

- dichloroethenyl)

- 2,2

- dimethylcyclopropanecarboxylate] is a racemic mixture of eight isomers (each with percentages of 11

- 14%). Zeta

- cypermethrin is an enrichment of four more efficacious isomers, and is therefore more insecticidally potent. While cypermethrin and zeta

- cypermethrin are separate active ingredients, each registered in separate end

- use products, they are included together in this risk asse ssment because of the close similarity of their uses, toxicity, and chemical characteristics. In this scoping document, the term “cypermethrins” is used when referring to both cypermethrin and zeta

- cypermethrin, whereas cypermethrin and zeta

- cypermethrin are used when referring to the specific end

- use products described above.
HED may need to reassess the endpoints and doses used for human health risk assessments for the cypermethrins. Based on a number of new use registration actions currently under r eview in HED, new endpoints and doses may be selected for the registration review risk assessment . The dose and endpoint selection process will rely on toxicology studies submitted in support of both cypermethrin and zeta

- cypermethrin. The toxicology dat abase for the cypermethrin s is complete including an immunotoxicity study and a developmental neurotoxicity ( DNT ) study

. Acute toxicity studies conducted with the cypermethrins i ndicate th ey are moderately acutely toxic via the oral route and ha ve low tox ic ity via the dermal and inhalation routes. They are mildly irritating to the eyes and skin and are not dermal sensitizer s
. Endpoints for risk assessment are generally based on neurotoxicity, which has been observed consistently across species; however, toxicity did not increase with an increased duration of exposure.
A screening level cumulative risk assessment was recently conducted for pyrethroid s , in which the Food Quality Protection Act ( FQPA ) Safety Factor of 3 X was retained for children < 6 years of age based on age

- dependent pharmacokinetics (USEPA, 2011) . The S afety F actor was reduced to 1X for adults and children ≥ 6. For new use assessments and during registration review, the FQPA factor for the cypermthrins will be evaluated in light of the cumulative risk assessment decision and other available data.

### 3 C ypermethrin has been classified as a possible human carcinogen, based on an increased incidence of lung adenomas and combined adenomas and carcinomas in female mice. However, the chronic to xicity endpoints selected for risk assessment are considered protective of any cancer risks. D ermal assessment s have not been completed for adults exposed to cypermethrins via the dermal route due to a lack of systemic toxicity in the 21

- day dermal study in the rat; however, due to potential susceptibility of offspring, HED conducted dermal assessments for children. This approach will be reconsidered during registration review based on the weight of evidence from the toxicology database

. T he dietary exposure database is adequate to support the registration review of the cy permethrins

. However, if the acute and chronic dietary endpoints change, an updated dietary risk assessment may be needed ; in addition, anticipated residues have been used in previous risk assessments , and may need to be updated

. Any updated dietary assessment would include more current percent crop treated estimates , new residue monitoring data , and if needed, updated drinking water estimates

. Currently, the re are n o dietary risk estimates of concern for the existing uses of the cy permethrins

. During registration review, the tolerance expressions for both cypermethrin and zeta

- cypermethrin should be revised to conform with current standards.
The residential exposu re database is adequate to support registration review for cypermethrin and zeta

- cypermethrin

. A ll of the residential handler and postapplication risk estimates are below the Agency’s level of concern. An updated residential exposure assessment may be needed during registration review as a result of the revisions to HED’s Residential Exposure Standard Operating Procedures (SOPs). Furthermore, because of the potential for residential bystander exposures due to cypermethrin and zeta

- cypermethrin from aer ial and airblast applications, volatilization, and/or transport from treated areas, HED will evaluate the need for a bystander assessment during registration review. For the cypermethrins, residential exposures are aggregated with dietary exposures. In t he most recent human health risk assessments, the re were no aggregate risk estimates of concern ( Memo, D344749, D. McNeilly et al ., 11/27/2007 ; Memo, D293416 , J. Doherty et al. , 4/06/2006 )

. During registration review, updated aggregate risk assessments ma y be needed; however, HED expects to update aggregate risk estimate s in conjunction with new uses currently under review

. The cypermethrins were included in HED’s recent cumulative risk assessment for synthetic pyrethroids (USEPA, 2011)

. The occupation al exposure database is adequate to support registration review for cypermethrin and zeta

- cypermethrin

. There are no occupational handler and postapplication risk estimates of concern. HED will consider the need for a n updated occupational exposure assessment d ur ing registration review.
Introduction HED evaluated the most recent human health risk assessments for cypermethrin and zeta

cypermethrin in association with the updates to their toxicity, exposure, and usage databases to determine if sufficient data are available and if further updates are needed to support registration review. Recent human health risk assessments include a 2007 assessment for the use of zeta

-

### 4 cypermethrin on citrus, oilseeds, safflower, wild rice and okra (Memo, D344749, D. McNeilly et al ., 11/27/2007) and the 200 6 Phase 4 HED Risk Assessment for the re

- registration of cypermethrin (Memo, D293416 , J. Doherty et al. , 4 / 06 /200 6 ). In addition, HED considered the latest Agency science policies an d risk assessment methodologies. The structure of the cypermethrins, as well as their chemical names and other identifiers can be found in the chemical identity table attached to this document (Attachment 1)

. Cypermethrin is registered for foliar applica tions to control a wide range of pests on agricultural food/feed crops using ground, sprinkler irrigation, or aerial equipment. Cypermethrin is also registered as a soil residual termiticide, for outdoor pest control to structures and lawns, indoor pest c ontrol (dilutable formulations for crack & crevice or spot treatments, total release foggers or aerial space sprays), livestock ear tags, and for application to horses. It can be used in industrial, commercial, and residential sites. The single active in gredient formulations of cypermethrin include the emulsifiable concentrate (EC), the soluble concentrate/liquid (SC/L), the granular (G), and the wettable powder (WP). Cypermethrin is a mixture of 8 stereoisomers. The mixture contains four sets of enan tiomers, each containing an isomer with either an “S” or “R” configuration at the cyano bearing carbon. Zeta

- cypermethrin is an enrich ment of the more insecticidal ly potent S

- isomers; 24% each of the “S” isomers and 1% each of the insecticidally less active “R” isomers. Zeta

- cypermethrin has been registered on the same agricultural crops as cypermethrin plus many more. Due to its greater insecticidal potency, z eta

- cypermethrin application rates are less than th ose for cypermethrin. Tolerances for residues of cypermethrin are listed under 40 CFR § 180.418(a)( 1), and include all eight stereoisomers

. Tolerances for residues of zeta

- cypermethrin are listed under 40 CFR § 180.418(a)(2), and are expressed in terms of zeta

- cypermethrin and i ts inactive R

- isomers. These tolerances are summarized in Appendix 5. Tolerances have been established for residues in crops as well as in livestock commodities

. These tolerances range in value from 0.05 to 40 ppm, with most of these tolerances being 15 .0 ppm or less. The tolerances are identical for all commodities where both cypermethrin and zeta

- cypermethrin are registered , which includes all livestock commodities; brassica; head lettuce ; onion; and pecan

. During registration review, the tolerance expressions should be revised so that they conform to current standards with respect to coverage and compliance

. The tolerance enforcement methods for plant and animal commodities do not distinguish between cypermethrin and zeta

cypermethrin , even though they have separate tolerance listings in the CFR

. Hazard Identification/ Toxicology As with the other pyrethroids, the cypermethrin s cause neurotoxicity in insects and mammals by the modulation of nerve axon sodium channels. Pyrethroids interfere with th e ability of the nervous system to relay nerve transmissions, and in mammals, can cause tremors, convulsions, salivation, and other clinical effects.

### 5 As previously described, zeta

- cypermethrin is an enrichment of the more insecticidally potent isomers o f c ypermethrin

. However, the mammalian toxicity of cypermethrin and zeta

cypermethrin are similar and therefore the databases of guideline toxicology studies for cypermethrin and zeta

- cypermethrin were combined in the most recent zeta

- cypermethrin risk as sessment (D344749, 11/27/07)

. The scientific quality of the submitted studies is high, and the toxicity profile is sufficient for characterization of potential carcinogenic, mutagenic, developmental, and reproductive effects. Since the most recent risk assessment, an immunotoxicity study has become available for hazard consideration and is currently under review

. Acute toxicity studies conducted with Zeta/ cypermethrin indicate that it is moderately acutely toxic via the oral route (Category II); howeve r, it is not very toxic via the dermal or inhalation routes (Categories III and IV, respectively). It is mildly irritating to the eyes and skin and is not a dermal sensitizer. In the subchronic and chronic oral studies, neurotoxic effects including tremo rs, gait abnormalities, ataxia and hypersensitivity were regularly observed at the study LOAELs. This class of compounds is known to induce clinical signs of neurotoxicity in mammals

. For example, gait abnormalities, tremors, reduced motor activity , and convulsions are typically observed across species, sexes , and routes of administration. In addition, p yrethroids are quickly absorbed and metabolized in vivo , preventing increased toxicity with repeated dosing. Dermal application of cypermethrin did not result in systemic toxicity in rats and rabbits

. The low rate of dermal penetration, combined with rapid metabolism and clearance, generally preclude toxicity of pyrethroids via the dermal route. Conversely, a 21

- day inhalation study for cypermethrin res ulted in lower NOAELs compared to the oral studies

. As a result, increased duration of dosing with cypermethrin did not result in greater potency. In fact, i ndications of chronic toxicity were limited to decreased body weight and lung tumors. These effe cts were only observed in the 2

- year carcinogenicity study in the mouse and occurred at significantly higher doses than the acute effects previously discussed.
Studies on the c ypermethrin s show ed no evidence of developmental or reproductive toxic ity

. In the prenatal developmental toxicity studies in rats and rabbits, there was no evidence of developmental toxicity up to the highest dose tested , including doses at which m aternal toxicity typical of pyrethroid was observed. In the multi

- generation reproduc tion studies in rats, offspring toxicity was observed at the same treatment level that resulted in parental systemic toxicity. There did not appear to be any increases in severity of toxicity for the pups in these studies . In the developmental neurotoxici ty ( DNT ) study , t here were no maternal effects at the highest dose tested. However, an offspring NOAEL and LOAEL were established based on reduced body weight and body weight gain in female pups

. Despite the limited susceptibility seen in the DNT , HED previously reduced the FQPA Safety Factor to 1X based on the weight of the evidence and the overall completeness of the database. However , the Agency has since determined that there is a potential for susceptibility of offspring to all pyrethroids based o n evidence of age

- dependent toxicity seen in literature studies (D381210, 6/27/11). The young appear to be more susceptible based on decreased metabolic

### 6 capacity to detoxify pyrethroids , and for the purpose of the pyrethroid cumulative risk assessment, HE D retained a 3X FQPA Safety Factor for children, and supported reduction to 1X for adults

. For new use assessments and during registration review, this approach will have an impact on the FQPA SF for the cypermethrins

. HED’s Cancer Peer Review Committee (CPRC) classified cypermethrin as a Group C “Possible human carcinogen”, based on an increased incidence of lung adenomas and adenomas plus carcinomas combin ed in female mice (CPRC, 1988). The presence of common benign tumor s in one species and one sex, w ith no increase in the proportion of malignant tumors or decrease in the time

- to

- tumor occurrence, together with the lack of mutagenic activity , was not considered strong enough to warrant a quantitative approach to assessing human cancer risk

. Consequent ly, the CPRC concluded that the chronic dietary assessment would be protective of potential cancer risk. This approach may need to be reconsidered in conjunction with new uses and during registration review

. In the most recent human health risk assessment for the cypermethrins, points

- of

- departure (PODs) for oral and inhalation exposure are based on both neurotoxic and systemic endpoints. Dermal risks were only assessed for children, by extrapolation from an oral study. The inhalation risk assessment was based on a route

- specific inhalation toxicity study in which salivation and decreased body weight were observed. Conclusions for Hazard Identification/Toxicology Cypermethrin technical is a mixture of eight isomers; zeta

- cypermethrin is an enrichment of four more efficacious isomers, and is more insecticidally potent. However, based on similar mammalian toxicity profiles, the toxicity databases are combined for purposes of risk assessment. The toxicology d atabase for the cypermethrin s is complete , and no additional data are being required during registration review. Following the completion of the screening level pyrethroid cumulative risk assessment, HED is in the process of updating endpoint selection fo r single chemical risk assessments for all pyrethroids. For the cypermethrins, evaluation of new uses may require HED to revise endpoints and doses selected for risk assessment prior to the completion of registration review

. Dietary Exposure As stated above, both cypermethrin and zeta

- cyperme t h rin are registered for use on a wide variety of crops

. Tolerances have also been established for residues in milk and eggs as well as in the fat, meat of cattle, goats, hogs, horses, sheep, and poultry , and meat byproducts of cattle, goats, horses, and sheep

. Ne a r ly all of the tolerances for cy permethrin and zeta

- cypermethrin are 15 .0 ppm or less. The only exceptions are zeta

- cypermethrin tolerances of 35 ppm for g rass, forage, fodder and hay, group 17 , hay and 40 ppm for a nimal feed, nongrass, group 18, hay

. HED used the Dietary Exposure Evaluation Model (DEEM

- FCIDTM Version 2.03) to conduct the most recent acute and chronic aggregate dietary (food and drinking water ) risk assessments for the cy perme thrin s . This model incorporate s consumption data from the USDA’s Continuing Survey of Food Intakes by Individuals taken between 19 94 and 199 6 along with a supplemental

### 7 children’s survey taken in 1998. T he acute dietary risk assessment was unrefined , i.e., tolerance

level residues and 100% crop treated were assumed for all commodities. The chronic dietary risk assessment was refined, with residue inputs based on field trial data, Pesticide Data Program (PDP) monitoring data , and percent crop treated estimates from BEAD

. The chronic dietary exposure has been refined to this extent because the chronic dietary exposure represents background exposure from food and water for aggregate risk assessment. The acute and chronic analyses were also based on ant icipated residu es (ARs) in animal commodities and both empirical and default processing factors

. The chronic dietary risk assessment i s considered protective of cancer effects. The last dietary exposure analysis included both cypermethrin and zeta

- cyper methrin

. The acute dietary exposure resulted in an estimated risk equivalent to 30 % of the aPAD (acute population adjusted dose) for the general U.S. population at the 9 5 th 

### percentile of exposure. The most highly exposed population subgroup was C hildren 1

- 2 years old , which u sed 54 % of the aPAD at the 9 5 th 

### percentile of exposure

. Even with an additional 3X FQPA Safety Factor, HED does not expect acute dietary risk concerns. C hronic dietary exposure to the cy permethrins resulted in an estimated risk equivalent to 1 % of the cPAD (chronic population adjusted dose) for the general U.S. population. The most highly exposed population subgroup was Children 1

- 2 , which used 3 % of the cPAD.
EFED recommended that model ed estim ates of residues in drinking water be used in the most recent dietary risk assessment. During registration review, HED will evaluate whether updated drinking water estimates are available and whether these revised estimates make it necessary to complete a new dietary assessment. Depending on the magnitude of any updates, a new dietary assessment may be required to appropriately estimate risks associated with drinking water exposure.
. Conclusions for Dietary Exposure The dietary exposure database is a dequate to support the existing registrations and tolerances

. No new residue chemistry data are required. A number of new uses are currently under review for zeta

- cypermethrin , and consequently a new dietary assessment , including food and drinking water, will be needed in support of those registration actions

. Therefore, the dietary assessments associated with these o ngoing registration actions may make completing a new dietary assessment during registration review unnecessary. However, a new dietary assessment may be needed if one or more of the following occur: new data are identified which impact dietary exposure estimates, including those from drinking water; new toxicological points o f departure are identified, including revisions to the FQPA SF; OPP dietary exposure policies and procedures are revised. HED is in the process of updating its dietary model to incorporate more recent consumption data from the National Health and Nutriti on Examination Survey (NHANES)

. This new version of the model will be used during registration review if a new dietary assessment is needed.

### 8 Residential Exposure and Risk Cypermethrin and z eta

- cypermethrin are registered for use in a variety of indoor and outdoor residential environments including: lawns, gardens, indoor surfaces and spaces, and on pets. Due to this use profile, adult residential homeowners may experience dermal and inhalation exposure to cypermethrin and zeta

- cypermethrin during application of the chemical (i.e., residential handler exposures). Adults and children may experience dermal, inhalation, and incidental oral (children only) expo sure to both active ingredients from contacting tre ated areas (i.e., residential postapplication exposure).

There are a variety of cypermethrin products currently registered for use by homeowners in residential settings

. For adults, t here is no hazard associated with dermal exposure to the cypermethrins, and consequently there are no dermal risks for adults . Residential inhalation risk estimate s are below HED’s level of concern (i.e., MOE > 100) for all residential handler scenarios. Residential handler intermediate

- or long

- term ex posures to cypermethrin or zeta

cypermethrin are not anticipated. Therefore, no intermediate

- or long

- term dermal or inhalation exposures or risks have been assessed. Residential Handlers

Residential postapplication exposure to the c ypermethrin s can occur when adults or children re

enter treated areas such as indoor surfaces and lawns, or come into contact with treated pets. No postapplication risks were identified for adults exposed via the dermal route , due to the lack of toxicity. For childre n, no risk estimate s of concern were identified for postapplication exposure via dermal and oral (i.e., hand

- to

- mouth) routes. Residential Postapplication

Previously, HED used default assumptions from the Residential Standard Operating Procedures (SOP), April 5, 2000 to assess resid ential handler and postapplication exposure. However, as a result of the revisions to the se SOPs, the parameters and algorithms for dermal and hand

- to

mouth exposure calculations are changing . For the indoor scenarios HED will use default assumptions fro m the Residential SOPs (2012). For the turf use, a Transferable Turf Residue (TTR) study is available for cypermethrin ; a liquid formulation was assessed in the study, even though the registered formulation used on turf is a granular . Although the TTR st udy was not conducted using a granular formulation, the study is considered adequate for the following reasons: 1) granulars are typically about an order of magnitude lower than the liquids in terms of transferability , so use of the study will not underest imate exposure to the granular formulation ; and 2) when a pesticide is available in several different formulations, a liquid formulation (e.g., emulsifiable concentrate) should be chosen for testing. Therefore, HED is not requesting a new TTR study with t he granular formulation

. D uring registration review, HED will review the TTR study so that it can be used quantitatively in risk assessment. In addition, HED may conduct a new residential exposure assessment that incorporates new methods or policies for estimating exposure associated with resi dential use patterns. T his update might occur prior to registration review, in conjunction with the evaluation of new uses. Based on the Agency’s current practices, a quantitative postapplication inhalation exposu re assessment has not been performed for the cypermethrin s , primarily because of their low vapor

### 9 pressure s . However, volatilization of pesticides may be a potential source of postapplication inhalation exposure to individuals nearby pesticide applications . The Agency sought expert advice and input on issues related to volatilization of pesticides from its Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (SAP) in December 2009. The Agency received the SAP’s final report on Mar ch 2, 2010 (http://www.epa.gov/scipoly/SAP/meetings/2009/120109meeting.html). The Agency is in the process of evaluating the SAP report and may, as appropriate, develop policies and procedures to identify the need for and, subsequently, the way to incorpo rate postapplication inhalation exposure into the Agency's risk assessments. If new policies or procedures are put into place, the Agency may revisit the need for a quantitative postapplication inhalation exposure assessment. Residential bystander exposu res might also occur as a result of cypermethrin and z eta

cypermethrin aerial and airblast applications and/or transport from treated areas. Spray drift is always a potential source of exposure to residents nearby to spraying operations. This is particularly the case with aerial application, but, to a lesser extent, could also be a potential source of exposure from ground

– based applications of cypermethrin and z eta

- cypermethrin . The Agency has been working with the Spray Drift Task Force, EPA Regional Offices and State Lead Agencies for pesticide regulation and other parties to develop the best spray drift management practices (see the Agency’ s Spray Drift website for more information at http://www.epa.gov/opp00001/factsheets/spraydrift.htm). Other potential sources of residential exposure include volatilization of pesticides and re

- suspension of dusts and/or particulates that contain pesticid es. Although a quantitative residential postapplication inhalation exposure assessment was not performed as a result of pesticide drift from neighboring treated agricultural fields, an inhalation exposure assessment was performed for flaggers, and is co nsidered representative of a worst case for inhalation (drift) exposure.

Recent occupational and residential exposure assessments evaluated exposure to children resulting from the use of insect control products conta ining zeta

- cypermethrin in homes (S. Wang, D337823, 3/30/2007 and S. Wang D344353, 9/20/2007). In the most recent human health risk assessment, the total dermal and oral exposure and risk estimates for children from the use of zeta

- cypermethrin products o n lawns and inside homes resulted in risks that were not of concern (D. McNeilly, D344749, 11/27/2007). Combined Residential Exposure and Risk

Conclusions for Residential Exposure and Risk Assessment The residential exposure database is adequate to support the registration review process for cypermethrin and zeta

- cypermethrin

. No new chemical

- specific exposure data are being requested in conjunction with registration review. An updated residential exposure assessment may be required under registration review as a result of the revisions to H ED’s Residential Exposure SOPs. An updated assessment may also be required if new data are identified which impact exposure estimates, or if there are new points of departure, a revised FQPA SF, or revisions to exposure policies and procedures. However, as noted above, many of these changes may be incorporated into new use risk assessments prior to the completion of registration review.

### 10 Aggregate Risk Assessment In the most recent risk assessment (Memo, D344749 , D

. McNeilly , 11 / 27 / 2007 ), a ggregate risk assessment s for combined zeta

- cypermethrin and cypermethrin exposures were conducted as follows: acute and chronic aggregate assessments were conducted based on food and water exposures, and short

- t erm aggregate assessments were conducted based on food, wa ter, and residential exposures. The latter were based on cypermethrin residential uses because its application rate is higher than that of zeta

- cypermethrin. No long

- term aggregate risk assessment w as conducted because no long

- term exposure scenarios are expected from residential uses of cypermethrin and zeta

- cypermethrin

. There were no aggregate risk estimate s of concern associated with the existing uses

. Conclusions for Aggregate Assessment During registration review, updated aggregate assessments ma y be conducted to include changes in toxicological endpoints , updated dietary exposure estimates, and updated residential exposure estimates. However, these updates may occur in conjunction with new use risk assessments, and therefore would not be needed during registration review. Occupational Exposure and Risk Occupational exposures to the c ypermethrin s result from use s on agricultural crops and animals, commercial lawns, and in and around industrial and commercial premises. Cypermethrin formulations include: liquid concentrates, granular, wettable powders, and ready

- to

- use products , foggers, trigger

- pump sprayers, impr egnated wipes, and ear tags. Zeta

- cypermethrin formulations include : liquid concentrates , granular and ready

- to

- use products . Applications to agricultural crops can be made with aerial, ground and handheld equipment. Applications at industrial and comme rcial sites can be made using handheld equipment. Occupational handler exposures have been evaluated for all cypermethrin and zeta

- cypermethrin registered uses.

Occupational and residential handler exposure was assessed using surrog ate data from the Pesticide Handlers Exposure Database (PHED ver. 1.1 ) and data from the Outdoor Residenti al Exposure Task Force (ORETF). For o ccupational handler s , s hort

- and intermediate

- term inhalation risk estimate s are below the Agency’s level of con cern at some level of risk mitigation (e.g., dust mist respirator or water

- soluble packaging). Occupational Handlers

Several occupational handler exposure scenarios were considered long

- term, including applications to residential, commercial, and industrial turf by commercial lawn care operators and applications by pest control operators. Since the toxicological endpoints of concern for long

- term exposures are based on similar adverse effects, long

- term dermal and inhalation risk estimate s were combined for occupational scenarios where long

- term exposures are anticipated. No l ong
- term risk estimate s for occupational handlers were identified. Based on new polic i es and procedures, during registration review, HED will re

- consider whether the previously

### 11 ide ntified and assessed long

- term exposure scenarios are still considered to be long

- term in duration

. Recently, PHED has been updated by the Occupational Pesticide Handler Unit Exposure Surrogate Reference Table ( September , 2011). In order to determine i f new assessments would be needed during registration review, HED conducted a cursory review of the revised inhalation handler unit exposures, and compared these to the previous unit exposures used to assess handler risks . Although there do not appear to be any risk estimate s of concern for registered uses based on the new unit exposures, HED may conduct updated handler exposure and risk assessments during registration review. Occupational Postapplication
P ostapplication risk estimate s for agricultural workers contact ing treat ed crops were not quantitatively assessed, since no short

- or intermediate

- term dermal endpoints of concern were identified , and since long

- term dermal exposures are not expected for tasks involving any of the registered crop use p atterns. A restricted

- entry interval (REI) of 12 hours is considered adequate based on the acute toxicity profiles of the cypermethrin and zeta

- cypermethrin technical material s
. Based on the Agency's current practices, a quantitative postapplication inhalation exposure assessment was not performed for cypermethrin and /or zeta

- cypermethrin . However, there are multiple potential sources of inhalation exposure to individuals performing postapplication activities in previously treated fields. These pot ential sources include volatilization of pesticides and re

- suspension of dusts and/or particulates that contain pesticides. The Agency sought expert advice and input on issues related to volatilization of pesticides from its Federal Insecticide, Fungicide , and Rodenticide Act Scientific Advisory Panel (SAP) in December 2009, and received the SAP’s final report on March 2, 2010 (http://www.epa.gov/scipoly/SAP/meetings/2009/120109meeting.html). The Agency is in the process of evaluating the SAP report as we ll as available postapplication inhalation exposure data generated by the Agricultural Reentry Task Force and may, as appropriate, develop policies and procedures, to identify the need for and, subsequently, the way to incorporate occupational postapplicat ion inhalation exposure into the Agency's risk assessments. If new policies or procedures are put into place, the Agency may revisit the need for a quantitative occupational postapplication inhalation exposure assessment for cypermethrin and zeta

- cypermet hrin

. Although a quantitative postapplication inhalation exposure assessment was not performed, an inhalation exposure assessment was performed for occupational/commercial handlers. Handler exposure resulting from application of pesticides outdoors is li kely to result in higher exposure than postapplication exposure. Therefore, since there were no risk estimates of concern identified for handler s, inhalation postapplication exposure is not expected to result in risk estimate s of concern

.

### 12 Conclusions for Occupational Exposure and Risk Assessment The occupational exposure database is adequate to support the registration review process for cypermethrin and zeta

- cypermethrin . Updated occupational handler exposure assessments may be needed during registr ation review based upon revisions to the Agency’s scenario

- specific surrogate handler exposure data (http://www.epa.gov/pesticides/science/handler

- exposure
table.pdf). Updated occupational postapplication exposure assessments may also be needed based on u pdated dermal transfer coefficients [ Science Advisory Council for Exposure Policy Number 3 (http://www.epa.gov/pesticides/science/exposac_policy3.pdf) ] . Revised occupational handler and postapplication assessments may also be needed if toxicological endpo ints change or other new data are received by the Agency which impact exposure estimates. However, these updates may be included in new uses risk assessments, prior to the completion of registration review. Public Health and Pesticide Epidemiology Data D396106, S. Recore, Jan. 3, 2012 For this evaluation, the OPP Incident Data System (IDS) was utilized to retrieve pesticide incident data on the active ingredients cypermethrin (PC Code 109702) and zeta

- cypermethrin (PC Code 129064). Main IDS incidents involving only one pesticide are considered to provide more certain information about the potential effects of exposure from the pesticide. When an incident involves more than one pesticide, it is difficult to determine which effects are attributed to the pesticide being considered. However, because cypermethrin is often co

- formulated with other active ingredients, it is important to consider the incidents involving multiple chemicals in this case. The less severe human incidents (minor, unknown, or no eff ects outcomes) are reported by registrants as counts called aggregate summaries and are recorded in a separate module called Aggregate IDS. Cypermethrin From January 1, 2006 to November 2, 2011, in the Main IDS there were 280 incidents reported for cype rmthrin only, with 278 of these exposure being classified as major or moderate (20 major, 258 moderate). In addition, 304 cypermethrin exposures that involved more than one chemical were also reported to Main IDS. Over the same time period, 4,285 exposur es were reported to Aggregate IDS involving cypermethrin, resulting in low severity outcomes (67 exposures classified as an unknown/no effects outcome, 4,218 classified as a minor outcome). The majority of health effects associated with these incidents involved dermal, neurological, gastrointestinal, and respiratory symptoms. Most of the cases occurred at home in a residential setting, although there were cases that occurred in occupational settings as well. Patients reported inhaling the product, or accidentally getting the product on their faces, hands, arms, and/or legs. These exposures occurred while the patients were applying or using the product either indoors or outdoors. Many incidents appeared to occur because the product was used improperly . That is, the applicator failed to follow the label directions, overused a product , or did not use personal protective equipment (e.g. gloves, masks, and/or protective clothing). In

### 13 some cases, exposures occurred because the applicator came in direct co ntact with cypermethrin after a leak or spill. Exposures also occurred after application. Although most of these incidents were of low severity, the overall high frequency of exposure to cypermethrin ha s the potential to result in high severity outcomes. Consequently, these incident data warrant further analysis in the preliminary risk assessment phase of Registration Review.
Zeta

- cypermethrin Overall, there are few incidents involving zeta

- cypermethrin reported and most are classified as moderate or low severity. Therefore, for zeta

- cypermethrin , b ased on the low frequency and severity of incident cases, there does not appear to be a concern a t this time that would warrant further investigation. The Agency will continue to monitor the incident information and if a concern is triggered, additional analysis will be included in the risk assessment.
Tolerance Assessment and International Harmoniz ation The nature of the residue in animals is adequately understood (D269584; Y. Donovan; Nov 3, 2000). HED previously concluded that, for the case of cypermethrin and zeta

- cypermethrin, the parent compound is the only residue of concern which needs to b e included in the tolerance expression and used for dietary risk assessment, including drinking water. Tolerances for residues of cypermethrin are listed under 40 CFR § 180.418(a)( 1), which includes all eight stereoisomers

. Tolerances for residues of zeta

- cypermethrin are listed under 40 CFR § 180.418(a)(2), and are expressed in terms of zeta

- cypermethrin and its inactive R

- isomers. The inclusion of the inactive R

- isomers in the tolerance expression is appropriate because the enforcement methods listed in PAM Volume II are not stereospecific; thus no distinction is made between residues of cypermethrin (all eight stereoisomers) and zeta

- cypermethrin (an enriched isomer form of cypermethrin). During registration review, the tolerance expressions should be revised so they address both coverage and measurement :
**•** T he tolerance expression for cypermethrin should be revised as follows:

“ Tolerances are established for residues of cypermethrin , including its metabolites and degradates, in or on the commodities in the table below. Compliance with the tolerance levels specified below is to be determined by measuring only cypermethrin

. ”

**•** The tolerance expression for zeta

- cypermethrin should be revised as follows:

“ Tolerances a re established for residues of zeta

- cypermethrin, including its metabolites and degradates, in or on the commodities in the table below. Compliance with the tolerance levels specified below is to be determined by measuring only zeta

cypermethrin.”
Code x has established maximum residue limits ( MRLs ) for cy permethrin , defined as “cy permethrin (sum of all isomers).”
For both cypermethrin and zeta

- cypermethrin , Mexico adopts U.S. tolerances and/or Codex MRLs for its export purposes. Canada has established MRLs for cypermethrin only . It has not

### 14 established MRLs for zeta

- cypermethrin per se
. In most cases, the Codex and Canadian MRLs differ from each other as well as from the U.S. tolerance.
The international residue limit status sheet can be found in Attachment 4

. During registration review, HED will reconsider the U.S. tolerances and will harmonize them with Codex MRLs to the extent possible

. Environmental Justice Potential areas of environmental justice concerns, to the extent possible, were considered in this human health risk assessment, in accordance with U.S. Executive Order 12898, "Federal Actions to Address Environmental Justice in Minority Populations and Low

- Income Populations," ( http://www.eh.doe.gov/oepa/guidance/justice/eo12898.pdf

. As a part of every pesticide risk assessment, OPP considers a large variety of consumer subgroups according to well

- established procedures. In line with OPP policy, HED estimates risks to population subgroups from pesticide exposures that are based on patterns of that subgroup’s food and water consumption, and activities in and around the home that involve pesticide use in a residential setting. Extensive data on food c onsumption patterns are compiled by the USDA under the Continuing Survey of Food Intake by Individuals (CSFII) and are used in pesticide risk assessments for all registered food uses of a pesticide. These data are analyzed and categorized by subgroups bas ed on age, season of the year, ethnic group, and region of the country. Additionally, OPP is able to assess dietary exposure to smaller, specialized subgroups and exposure assessments are performed when conditions or circumstances warrant. Whenever appro priate, non

- dietary exposures and risks based on home use of pesticide products for adult applicators and postapplication activities for toddlers, youths, and adults entering or playing on treated areas are evaluated. Further considerations are currently in development as OPP has committed resources and expertise to the development of specialized software and models that consider exposure to bystanders and farm workers as well as lifestyle and traditional dietary patterns among specific subgroups.
Endocri ne Disruptor Screening Program As required by FIFRA and FFDCA, EPA reviews numerous studies to assess potential adverse outcomes from exposure to chemicals. Collectively, these studies include acute, subchronic and chronic toxicity, including assessments of carcinogenicity, neurotoxicity, developmental, reproductive, and general or systemic toxicity. These studies include endpoints which may be susceptible to endocrine influence, including effects on endocrine target organ histopathology, organ weights, e strus cyclicity, sexual maturation, fertility, pregnancy rates, reproductive loss, and sex ratios in offspring. For ecological hazard assessments, EPA evaluates acute tests and chronic studies that assess growth, developmental and reproductive effects in different taxonomic groups. As part of the most recent registration decision in 200 6 , EPA reviewed these data and selected the most sensitive endpoints for relevant risk assessment scenarios from the existing hazard database. However, as required by FFD CA section 408(p), cypermethrin is subject to the endocrine screening part of the Endocrine Disruptor Screening Program (EDSP).

### 15 EPA has developed the EDSP to determine whether certain substances (including pesticide active and other ingredients) may have an effect in humans or wildlife similar to an effect produced by a “naturally occurring estrogen, or other such endocrine effects as the Administrator may designate.” The EDSP employs a two

- tiered approach to making the statutorily required determinations . Tier 1 consists of a battery of 11 screening assays to identify the potential of a chemical substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal systems. Chemicals that go through Tier 1 screening and are found to have the potential to interact with E, A, or T hormonal systems will proceed to the next stage of the EDSP where EPA will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2 testing is designed to identify any adverse end ocrine

- related effects caused by the substance, and establish a dose

- response relationship between the dose and the E, A, or T effect. Under FFDCA section 408(p), the Agency must screen all pesticide chemicals. Between October 2009 and February 2010, EPA issued test orders/data call

- ins for the first group of 67 chemicals, which contains 58 pesticide active ingredients and 9 inert ingredients. Cypermethrin was included on that list and has been issued an order to conduct the Tier 1 testing. Once all requ ired Tier 1 and Tier 2 data have been received and reviewed, the endpoints and safety factors used for risk assessment purposes will be examined and a new risk assessment performed if necessary. For further information on the status of the EDSP, the polic ies and procedures, the list of 67 chemicals, future lists, the test guidelines and the Tier 1 screening battery, please visit our website: http://www.epa.gov/endo/

. Cumulative Risk Assessments The Food Quality P rotection Act (FQPA) requires the Agency to consider the cumulative risks of chemicals sharing a common mechanism of toxicity. The cypermethrins are included in the pyrethroid/pyrethrin common mechanism group ( htt p://www.regulations.gov ; EPA

- HQ

- OPP

2008

- 0489

- 0006). The members of this group share the ability to interact with voltage

- gated sodium channels ultimately leading to neurotoxicity. The cumulative risk assessment for the pyrethroids/pyrethrins was publishe d on Nov. 9, 2011 and is available at http://www.regulations.gov ; EPA

- HQ

- OPP

- 2011

- 0746. No cumulative risks of concern were identified allowing the Agency to consider new uses for pyrethroid actives. For informat ion regarding EPA’s efforts to evaluate the risk of exposure to pyrethroids, refer to http://www.epa.gov/oppsrrd1/reevaluation/pyrethroids

- pyrethrins.html

. Human Studies
Past cy permethrins risk assessments rely in part on data from studies in which adult human subjects were intentionally exposed to a pesticide to determine their dermal and inhalation exposure. These data, which include studies from the Pesticide Handlers Exposure Database Version 1.1 (PHED 1.1); the Outdoor Residential Exposure Task Force (ORETF) database; the Agricultural Re

- entry Task Force (ARTF) database; and other registrant

- submitted expos ure monitoring studies, are subject to ethics review pursuant to 40 CFR 26, have received that review, and are compliant with applicable ethics requirements. For certain studies that review may have included review by the Human Studies Review Board. Desc riptions of data sources as

### 16 well as guidance on their use can be found at http://www.epa.gov/pesticides/science/handler

exposure
- data.html and http://www.epa.gov/pesticides/science/post

- app
- exposure
- data.html. Data Requirements
No new data requirements ( for human health risk assessment) have been identified for the cy permethrins to support registration review.
R eferences Cypermethrin and Zeta

- Cypermethrin

– Conclusions of the Meeting of Metabolism Assessment Review Committee D269584; Y. Donovan; Nov 3, 2000. Cypermethrin: Phase 4 HED Risk Assessment for the Reregistration Eligibility Decision (RED). PC Code 109702; DP Barcode D293416. April 6, 2006.
Zeta

- Cypermethrin : Addendum to “ Occupational and Residential Risk Assessment to Support Request for a Section 3 Registration of New Use of Zeta

- Cypermethrin” D337823. March 30, 2007.
Z eta

- cypermethrin/cypermethrin. Ac ute and Chronic Dietary (Food and Drinking Water) Exposure and Risk Assessments for Section 3 Use of Zeta

- cypermethrin on Citrus (Crop Group 10), Oilseed Commodities (except cottonseed), Okra, Safflower, and Wild Rice. PC Codes: 109702 & 129064. PP# s: 6F7132, 6E7133, and 6F7057. Decision No.: D371717. DP Barcode: D335224. Dennis McNeilly, Nov 5, 2007.
Zeta

- cypermethrin : Human Health Risk Assessment for Section 3 Use of Zeta

- cypermethrin on Citrus (Crop Group 10), Oilseeds (proposed Crop Group 2 0, except cottonseed), Safflower, Wild Rice and Okra. PC Code: 129064. DP Number: D344749. Dennis McNeilly, Nov. 27, 2007. USEPA (2011). "Pyrethroid Cumulative Risk Assessment, D394567, 10/04/11." Available at: http://www.regulations.gov/#!docume ntDetail;D=EPA

- HQ

- OPP

- 2011

- 0746

- 0003 Cypermethrin and Zeta

- Cypermethrin : Review of Human Incidents . Shanna Recore. D 396106. January 3, 2012

. Attachment s Attachment 1

. Chemical Identity Table Attachment 2. Cypermethrin and Zeta

- Cypermethrin Endpoint Selection Tables Attachment 3

. Cypermethrin and Zeta

- Cypermethrin Products and Use Sites Attachment 4. International Residue Limit Status

### 17 Attachment 1
. Chemical Identity Table
Chemical Identity Common Name Cypermethrin and Zeta

- Cypermethrin CAS Name Cypermethrin: (±)

- alpha

- 3

- cyano
- (3

- phenoxyphenyl)methyl [(±)

- cis, trans

- 3(2,2

- dichloroethenyl)

- 2,2

- dimethylcyclopropanecarboxylate
Zeta
- Cypermethrin: (S)

- cyano(3

- phenoxyphenyl)methyl (±)

- cis

- trans

- 3

- (2,2

- dichloroethenyl)

- 2,2

- dimethylcyclopropanecarboxylate IUPAC Name Cypermethrin: (RS)

- α
- cyano
- 3

- phenoxybenzyl (1RS,3RS, 1RS,3SR)

- 3

- (2,2

- dichlorovinyl)

- 2,2

- dimethylcyclopropanecarboxylate or (RS)

- α
- cyano
- 3

- phenoxybenzyl (1RS)

- cis

- trans

- 3

- (2,2

- dichlorovinyl)

- 2,2

- dimethylcyclopropanecarboxylate
Zeta
- Cypermethrin: (S)

- α
- cyano
- 3

- phenoxybenzyl (1R)

- cis

- trans

- 3

- (2,2

- dichlorovinyl)

- 2,2

- dimethylcyclopropanecarboxylate or (S)

- α
- cyano
- 3

- phenoxybenzyl (1RS, 3RS, 1SR, 3SR)

- 3

- (2,2

- dichlorovinyl)

- 2,2

- dimethylcyclopropanecarboxylate PC Code s Cypermethrin : 1 09702 Zeta

- Cpermethrin : 12 0964 Chemical Abstracts Number s Cypermethrin : 52315

- 07

- 8 Zeta

- Cypermethrin: 97955

- 44

- 7 Registration Review Case No. 2130 Chemical Class Pyr ethroid Insecticide Vapor Pressure 1.9 x 10 - 9 mm Hg at 25°C Chemical Structure
Cl

Cl O O 

### O H N

### 18 Attachment 2
. Cy permethrin s Endpoint Selection Table

Summary of Toxicological Doses and Endpoints for Zeta
- cypermethrin/cypermethrin for Use in Human Risk Assessments ( Studies are conducted with cypermethrin unless specified otherwise ). Exposure/ Scenario Dose Used in Risk Assessment, UF FQPA SF and Level of Concern for Risk Assessment Study and Toxicological Effects

Acute Dietary (General population including infants and children) NOAEL = 10.0 mg/kg/day
UF = 100 Acute RfD = 0.1 mg/kg/day FQPA SF = 1 aPAD = FQPA SF Acute RfD

= 0.1 mg/kg/day Acute neurotoxicity study in the rat (zeta

- cypermethrin). LOAEL = 50 mg/kg/day based on clinical signs of neurotoxicity and changes in the FOB. Chronic Dietary (All populations) NOAEL = 6 mg/kg/day
UF = 100 Chronic RfD = 0.06 mg/kg/day FQPA SF = 1 cPAD = FQPA SF Chronic RfD

= 0.06 mg/kg/day Chronic feeding study in the dog. LOAEL = 20.4/18.1mg/kg/day based on clinical signs of neurotoxicity and mortality in males and decreased body weight and body weight gain in females. Short

- term Incidental Oral (1

- 30 days) NOAEL = 7.4 mg/kg/day Residential LOC for MOE = 100 Occupational LOC for MOE = N/A Developmental neurotoxicity study in the rat (zeta

- cypermethrin). LOAEL = 17 mg/kg/day based on decreased body weight in the offspring

Intermediate

- term Incidental Oral (1

- 6 months) NOAEL = 7.4 mg/kg/day Residential LOC for MOE = 100 Occupational LOC for MOE = N/A Developmental neurotoxicity study in the rat (zeta

- cypermethrin). LOAEL = 17 mg/kg/day based on decreased body weight in the offspring. Short and Intermediate

- Term Dermal ( Infants and children only; 1 day

- 6 months) NOAEL = 7.4 mg/kg/day ( D ermal absorption factor = 2.5%) Residential LOC for MOE = 100 Developmental neurotoxicity study in the rat (zeta

- cypermethrin). LOAEL = 17 mg/kg/day based on decreased body weight in the offspring.

Short and Intermediate

- Term Dermal ( Adults workers; 1 day

- 6 months) None None No systemic effects in 21

- day dermal study (zeta

- cypermethrin) up to 1000 mg/kg/day & no developmental concern. No hazard identified to support quanti fic ation of risk. Dermal Long

- Term (> 6 months) Oral NOAEL = 6 mg/kg/day ( D ermal absorption factor = 2.5%) Residential LOC for MOE = 100 Occupational LOC for MOE = 100 Chronic feeding study in the dog. LOAEL = 20.4/18.1 mg/kg/day based on clinical signs of neurotoxicity and mortality in males, and decreased body weight and body weight gain in females. Short and Intermediate

- Term Inhalation (1

- 6 months) NOAEL = 0.01 mg ai/L (2.7 mg/kg/day) Residential LOC for MOE = 100 Occupational LOC for MOE = 100 21

- day inhalation study in the rat. LOAEL = 0.05 mg/kg/day based on decrease s in body weight and salivation.

### 19 Summary of Toxicological Doses and Endpoints for Zeta
- cypermethrin/cypermethrin for Use in Human Risk Assessments ( Studies are conducted with cypermethrin unless specified otherwise ). Exposure/ Scenario Dose Used in Risk Assessment, UF FQPA SF and Level of Concern for Risk Assessment Study and Toxicological Effects

Long

- Term Inhalation (> 6 months) NOAEL = 0.01mg ai/L (2.7 mg/kg/day) Residential LOC for MOE = 300 Occupational LOC for MOE = 300

– for the lack of an alternative study. Route

- to

- route estimation would result in less protective endpoint. 21

- Day inhalation study in the rat. LOAEL = 0.05 mg/kg/day based on decrease s in body weight and salivation.

Cancer (oral, dermal, inhalation) Classification: P ossible human carcinogen. No quanti fic ation required. The chronic RfD /PAD will adequately account for all chronic toxicity effects, including carcinogenicity, likely to result from exposure to this pesticide. UF = uncertainty factor, FQPA SF = Any additional safety factor retained to account for data deficiencies or resi dual concerns unique to the FQPA, NOAEL = no observed adverse effect level, LOAEL = lowest observed adverse effect level, PAD = population adjusted dose (a = acute, c = chronic) RfD = reference dose, MOE = margin of exposure, LOC = level of concern, NA = n ot applicable.

### Attachment 3. Cypermethrin and Zeta
- Cypermethrin Products and Use Sites
The currently registered products containing cypermethrin and zeta

- cypermethrin as an active ingredient are listed in the table below.

Cypermethrin Products and Use Sites. F ormulation Type % Active Ingredient EPA R eg . N o . R egistered Product Name Registered Use Sites

L IQUID (L) 30.6 1381

- 188 BATTERY 2.5 EC AGRICULTURAL FOOD CROPS 0.6 270

- 250 FARNAM CRASH! FLY SPRAY CONCENTRATE ANIMAL TREATMENT
READY

- TO

- USE ( RTU ) 0.1 1543

- 1 WFY0901 AGRICULTURAL/FARM STRUCTURES / BARNS/BARNYARDS/AUCTION BARNS , ANIMAL TREATMENT 0.515 73049

- 453 CYPER

- ACTIVE 515 ANIMAL KENNELS/SLEEPING QUARTERS , BARNS , BATHROOM /HARD SURFACES , COMMERCIAL/ INDUSTRIAL PREMISES (INDOOR) , COMMERCIAL STORAGES/WAREHOUSES COMMERCIAL , TRANSPORTATION FACILITIES , HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DOMESTIC DWEL LINGS (INDOOR), NONFOOD STORAGE AREAS , PET LIVING/SLEEPING QUARTERS , SHIPS AND BOATS 0.15 270

- 251 FARNAM CRASH FLY SPRAY ANIMAL TREATMENT
0.15 270

- 253 FARNAM CRASH! WIPE

ON INSECTICIDE/REPELLENT ANIMAL TREATMENT

1 .0 53883

- 150 CYPER 1% HORSE SPRAY ANIMAL TREATMENT 17.5 53883

- 152 CYPER HORSE SPOT

- ON ANIMAL TREATMENT 1 .0 69332

- 5 ECTOMETHRIN H20 EQUINE SPRAY ANIMAL TREATMENT
0.21 100

- 1303 CYPERMETHRIN ME 0.2% RTU HOUSEHOLD/DOMESTIC DWELLINGS ( INDOOR/OUTDOOR ), ORNAMENTAL AND/OR SHADE TREES PATHS/PATIOS , RESIDENTIAL LAWNS , WOOD PROTECTION TREATMENT ( INDOOR ) P RESSURIZED LIQUID (PRL) 0.05 1021

- 1856 MULTICIDE 28661 BATHROOM PREMISES/HARD SURFACES , COMMERC IAL STORAGES/WAREHOUSES, HOUSEHOLD/DOMESTIC DWELLINGS , INDOOR FOOD HANDLING AREAS , PET LIVI NG/SLEEPING QUARTERS , SOLID WASTE CONTAINERS , PET LIVING/SLEEPING QUARTERS 0.05 73049

- 157 CYPERMETHRIN/ESBIOTH RIN/PIPERONYL BUTOXIDE 0.05%/0.1%/0.4% APS ANIMAL KENNELS/SLEEPING QUARTERS , BATHROOM PREMISES/HARD SURFACES COMMERCIAL/ INDUSTRIAL PREMISES (OUTDOOR) , COMME RCIAL TRANSPORTATION FACILITIES, DAIRIES/CHEESE PROCESSING PLANT , DAIRY FARM MILK STORAGE ROOMS/HOUSES/SHEDS ANIMAL TREATMENT ( DOGS ), DRAINAGE SYSTEMS , EATING ESTABLISHMENTS , EGG PACKING PLANTS (COMMERCIAL) , FOOD STORES/MARKETS/SUPERMARKE TS PREMISES , GREENHOUSE

- EMPTY GREENHOUSES

- IN USE , ANIMAL TREATMENT, HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DOMESTIC DWELLINGS , SWIMMING POOL WATER SYSTEMS SEED HOUSES/STORES/STORAGE AREAS/WAREHOUSES , PAVED AREAS (PRIVATE OADS/SIDEWALK S) PATHS/PATIOS , PET LIVING/SLEEPING QUARTERS , REFUSE/SOLID WASTE SITES (OUTDOOR) , PUBLIC BUILDINGS/STRUCTURES 0.03 1021

- 1855 MULTICIDE CRAWLING INSECT KILLER RESIDENTIAL HOUSEHOLD/DOMESTIC DWELLINGS INDOOR PREMISES
1.716 4822

- 452 RAID FOGGER K HOUSEHOLD/DOMESTIC DWELLINGS (INDOOR) 0.824 73049

- 454 CYPER

- ACTIVE E2 WB HOUSEHOLD/DOMESTIC DWELLINGS , INDOOR NONFOOD HANDLING AREAS

### 21 TRA 73049

- 455 CYPER

- ACTIVE AS2 TRA HOUSEHOLD/DOMESTIC DWELLINGS , INDOOR NONFOOD HANDLING AREAS 0.515 9688

- 249 CHEMSICO AEROSOL INSECTICIDE CF HOUSEHOLD/DOMESTIC DWELLINGS , PET LIVING/SLEEPING QUARTERS
0.86 9688

- 252 CHEMSICO AEROSOL INSECTICIDE NMR HOUSEHOLD/DOMESTIC DWELLINGS
0.6 9688

- 254 CHEMSICO AEROSOL INSECTICIDE GBR HOUSEHOLD/DOMESTIC DWELLINGS
0.03 1021

- 2559 MGK 29461 HOUSEHOLD/DOMESTIC DWELLINGS INDOOR NONFOOD HANDLING AREAS (INDOOR RESIDENTIAL) 0.05 4822

- 553 RWH 33 NONAGRICULTURAL UNCULTIVATED AREAS/SOILS 498

- 190 CHAMPION SPRAYON INDOOR FOGGER HOUSEHOLD/DOMESTIC DWELLINGS INDOOR NONFOOD HANDLING AREAS , PET LIVING/SLEEPING QUARTERS , SHIPS AND BOATS , PET LIVING/SLEEPING QUARTERS 0.1 4822

- 447 RAID ANT & ROACH 17 HOUSEHOLD/DOMESTIC DWELLINGS INDOOR PREMISES W ETTABLE POWDER (WP) 40 100

- 990 DEMON WP INSECTICIDE AGRICULTURAL/FARM STRUCTURES/AIRPORTS/LANDING FIELDS , ANIMAL HOUSES, COMMERCIAL/INDUSTRIAL (INDOOR) , COMME RCIAL TRANSPORTATION FACILITIES, EATING ESTABLISHMENTS , FOOD PROCESSING PLANT , FOOD STORES/MARKETS/SUPERMARKETS PREMISES GREENHOUSES

- IN USE , HOSPITALS/MEDICAL INSTITUT IONS (HUMAN/VETERINARY) , HOUSEHOLD/DOMESTIC DWELLINGS , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , NONAGRICULTURAL RIGHTS

- OF

- WAY , ORNAMENTAL AND/OR SHADE TREES , LAWNS AND TURF PATHS/PATIOS , POULTRY PROCESSING PLANT, SEWAGE DISPOSAL AREAS , UTILITY POLES / RIGHT

- OF

WAY , WOOD PROTECTION TREATMENT 40 279

- 3070 CYNOFF WP INSECTICIDE AIRPORTS/AUTOMOBILES, TAXIS, LIMOUSINES, RECREATIONAL VEHICLES, & TIRES , BARNS , COMMERCIAL /INDUSTRIAL PREMISES (INDOOR) , EATING ESTABLISHMENTS , FOOD PROCESSING PLANT, FOOD STOR ES/MARKETS/SUPERMARKETS PREMISES , GREENHOUSES

- IN USE , HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) HOUSEHOLD/DOMESTIC DWELLINGS , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , ORNAMENTAL AND/OR SHADE TREES , LAWNS AND TURF , PATHS/PATIOS , RECREATIONAL A REAS , RESIDENTIAL LAWNS , SOLID WASTE SITES (OUTDOOR) , STORAGES/WAREHOUSES PREMISES , COMMERCIAL TRANSPORTATION FACILI TIES, DRAINAGE SYSTEMS EATING ESTABLISHMENTS , EGG HANDLING ROOMS (COMMERCIAL) , ELECTRICAL SUPPLIES/EQUIPMENT , FEED MILLS/FEED PROCESSING PLANTS , INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR) , MEAT /POULTRY PROCESSING PLANT , WOOD PROTECTION TREATMENT 40 100

- 1000 DEMON WP INSECTICIDE IN WATER

- SOLUBLE PACKETS COMMERCIAL/INDUSTRIAL PREMISES (INDOOR) , COMMERCIAL STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTATION FACILITIES , DRAINAGE SYSTEMS , EATING ESTABLISHMENTS , EGG HANDLING ROOMS (COMMERCIAL) , ELECTRICAL SUPPLIES/EQUIPMENT , FEED MILLS/FEED PROCESSING PLANTS , FOOD PROCESSING PLANT , GREENHOUSES

- IN USE , HOSPITALS/MED ICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DOMESTIC DWELLINGS , INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR) , MEAT PROCESSING PLANT, ORNAMENTAL LAWNS AND TURF , SOLID WASTE SITES (OUTDOOR) , WOOD PROTECTION TREATMENT 40 53883

- 29 VIPER WP BONIDE CYPER WSP INSECTICIDE COMMERCIAL/INDUSTRIAL PREMISES (INDOOR) , COMMERCIAL TRANSPORTATION FACILITIES , EATING ESTABLISHMENTS , EGG HANDLING ROOMS (COMMERCIAL) , FOOD PROCESSING PLANT , FOOD STORES/MARKETS/SUPERMARKETS PREMISES , HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VET ERINARY) , HOUSEHOLD/DOMESTIC DWELLINGS , MEAT /POULTRY PROCESSING PLANT, NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , NONAGRICULTURAL RIGHTS

- OF

- WAY , ORNAMENTAL AND/OR SHADE TREES , LAWNS AND TURF , PATHS/PATIO , SOLID WASTE SITES (OUTDOOR) , WOOD PROTECTION TRE ATMENT 40 4

- 482 HOUSEHOLD/DOMESTIC DWELLINGS , PATHS/PATIOS , REFUSE/SOLID WASTE SITES (OUTDOOR) RESIDENTIAL LAWNS , WOOD PROTECTION TREATMENT EMULSIFIABLE CONCENTRATE (EC) 25.3 100

- 1004 DEMON EC INSECTICIDE BATHROOM PREMISES/HARD SURFACES , COMMERCIAL/ INDUSTRIAL (OUTDOOR) , COMMERC IAL STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTATION FACILITIES , DRAINAGE SYSTEMS , EATING ESTABLISHMENTS, FOOD/GROCERY/MARKETING/STORA GE/DISTRIBUTION FACILITY, FOOD

### 22 PROCESSING PLANT, HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERI NARY) , HOUSEHOLD/DOMESTIC DWELLINGS (OUTDOOR), ORNAMENTAL AND/OR SHADE TREES , HERBACEOUS PLANTS , LAWNS AND TURF , ORNAMENTAL NONFLOWERING PLANTS / WOODY SHRUBS AND VINES , SOLID WASTE SITES , WOOD PROTECTION TREATMENT 25.3 100

- 1006 PROBUILD TC TERMITICIDE BARNS, COMMERCIAL/INDUSTRIAL PREMISES (INDOOR /OUTDOOR ) , COMMERCIAL S TORAGES/WAREHOUSES , COMMERCIAL TRANSPORTATION FACILITIES , EATING ESTABLISHMENTS , FOOD PROCESSING PLANT, GREENHOUSE

- EMPTY , HOSPITAL S/MEDICAL INSTITUTIONS , ( HUMAN/VETERINARY) , HOUSEHOLD/DOM ESTIC DWELLINGS , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , ORNAMENTAL AND/OR SHADE TREES , ORNAMENTAL LAWNS AND TURF , ORNAMENTAL WOODY SHRUBS AND VINES , PATHS/PATIOS , RESIDENTIAL LAWNS , SHIPS AND BOATS UTILITY POLES / RIGHT

- OF

- WAY , WOOD PROTECTION TREATMENT 25.3 100

- 1109 CYPER EC INSECTICIDE COMMERCIAL/INDUSTRIAL PREMISES , FENCERO WS, HOUSEHOLD/DOMESTIC DWELLINGS , ORNAMENTAL AND/OR SHADE TREES , WOOD PROTECTION TREATMENT 25.3 100

- 1218 DEMON MAX INSECTICIDE BARNS , COMMERCI AL STORAGES/WAREHOUSES PREMISES, COMMERCIAL TRANSPORTATION FACILITIES , EATING ESTABLISHMENTS , FOOD PROCESSING PLANT, GREENHOUSE

- EMPTY , HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DOMESTIC DWELLINGS , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCT URES , ORNAMENTAL AND/OR SHADE TREES , LAWNS AND TURF , ORNAMENTAL WOODY SHRUBS AND VINES , PATHS/PATIOS , SHIPS AND BOATS , UTILITY POLES / RIGHT

- OF

- WAY , WOOD PROTECTION TREATMENT 2.08 100

- 1302 CYPERMETHRIN ME 2.0% CONCENTRATE HOUSEHOLD/DOMESTIC DWELLINGS , ORNAMENTAL AND/OR SHADE TREES , LAWNS AND TURF , ORNAMENTAL WOODY SHRUBS AND VINES , PATHS/PATIOS , WOOD PROTECTION TREATMENT 24.8 228

- 616 CYPERMETHRIN E

- PRO TERMITICIDE/INSECTICID E AIRPORTS/LANDING FIELDS , AUTOMOBILES, TAXIS, LIMOUSINES, RECREATIONAL VEHICLES, & TIRES BARNS , COMMERCIAL TRANSPORTATION FACILITIES , EATING ESTABLISHMENTS , FOOD STORES/MARKETS/SUPER MARKETS, GREENHOUSE

- EMPTY , HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DOMESTIC DWELLINGS , NONAGRICULTURAL OUTDOOR BUILDINGS/STR UCTURES , ORNAMENTAL AND/OR SHADE TREES , LAWNS AND TURF , ORNAMENTAL NONFLOWERING PLANTS / WOODY SHRUBS AND VINES , PATHS/PATIOS , PUBLIC BUILDINGS/STRUCTURES , RECREATIONAL AREAS , SOLID WASTE SITES (OUTDOOR) , RESIDENTIAL LAWNS , UTILITY POLES / RIGHT

- OF

- WAY , WOOD PROTECTION TREATMENT 30.6 279

- 3027 AMMO 2.5 EC INSECTICIDE AGRICULTURAL FOOD CROPS
24.8 279

- 3081 CYNOFF EC INSECTICIDE AIRPORTS/LANDING FIELDS , AUTOMOBILES, TAXIS, LIMOUSINES, RECREATIONAL VEHICLES, & TIRES , COMMERCIAL/ INDUSTRIAL PREMISES , COMMERCIAL STORAGES/WAREHOUSES , COMMERCIAL TRANSPORTATION FACILITIES , EATING ESTABLISHMENTS , FOOD PROCESSING PLANT , FOOD STOR ES/MARKETS/SUPERMARKETS, GREENHOUSE

- EMPTY , HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DOMESTIC DWELLINGS , NONAGRI CULTURAL OUTDOOR B UILDINGS/STRUCTURES , PATHS/PATIOS , SOLID WASTE SITES , RESIDENTIAL LAWNS 24.8 279

- 3082 PREVAIL FT TERMITICIDE COMMERCIAL/INDUSTRIAL PREMISES , COMMERCIAL STORAGES/WAREHOUSES PREMISES , COMMERCIAL TRANSPORT ATION FACILITIES, FOOD PROCESSING PLANT, GREENHOUSE

- EMPTY , HOSPITALS/MEDICAL I NSTITUTIONS, HOUSEHOLD/DO MESTIC DWELLINGS, NONAGRICULTURAL RIGHTS

- OF

- WAY, ORNAMENTAL AND/OR SHADE TREES , SOLID WASTE SITES, RESIDENTIAL LAWNS , WOOD PROTECTION TREATMENT 26 3

- 12 HARRIS HOME PEST CONTROL CONCENTRATE ANIMAL KENNELS /SLEEPING QUARTERS, AUTOMOBILES, TAXIS, LIMOUSINES, RECREATIONAL VEHICLES, & TIRES , BARNS , COMMERC IAL STORAGES/WAREHOUSES, EATING ESTABLISHMENTS , EGG PACKING PLANTS , FE ED MILLS/FEED PROCESSING PLANTS, FOOD PROCESSING PLANT , FOOD STOR ES/MARKETS/SUPERMARKETS, HOSPITAL S/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DOMESTIC DWELLINGS , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , NURSERY STOCK , ORNAMENTAL HERBACEOUS PLANTS , LAWNS AND TURF , ORNAMENTAL NONFLOWERING PLANTS / WOODY SHRUBS AND VINES , PATHS/PATIOS , PET LIVING/SLEEPING QUARTERS , SEED HOUSES/STORES/STORAGE

### 23 AREAS/WAREHOUSES 30.6 34704

- 875 CYPERMETHRIN 2.5 EC AGRICULTURAL FOOD CROPS 25.3 34704

- 887 CYPERMETHRIN 25 BARNS , COMMERCIAL/ INDUSTR IAL PREMISES, HOUSEHOLD/DO MESTIC DWELLINGS, NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , ORNAMENTAL AND/OR SHADE TREES , ORNAMENTAL LAWNS AND TURF , ORNAMENTAL WOODY SHRUBS AND VINES , PATHS/PATIOS , SOLID WASTE SITES, RESIDENTIAL LAWNS , UTILITY POLES / RIGHT

- OF

- WAY , WOOD PROTECTION TREATMENT 24.8 34704

- 897 CYPRO TERMITICIDE/INSECTICID E AGRICULTURAL/FARM STRUCTURES/BUILDINGS , BARNS, COMMERCIAL/INDUSTR IAL PREMISES, COMMERC IAL STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTATION FACILITIES

NONFEED/NONFOOD , EATING ESTABLISHMENTS , FO OD PROCESSING PLANT, FOOD STOR ES/MARKETS/SUPERMARKETS, GREENHOUSE

- EMPTY , HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DOMESTIC DWELLINGS , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , R IGHTS

- OF

- WAY, NONAGRICULTURAL UNCULTIVATED AREAS/SOI LS , ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / NONFLOWERING PLANTS / WOODY SHRUBS AND VINES , LAWNS AND TURF , PATHS/PATIOS , RECREATIONAL AREAS , RECREATION AREA LAWNS , SOLID WASTE SITES, RESIDENTIAL LAWNS , UTILITY POLES , WOOD PROTECTION TREATMENT 26 4

- 427 BONIDE CYPERACTIVE ANIMAL KENNEL S/SLEEPING QUARTERS, AUTOMOBILES, TAXIS, LIMOUSINES, RECREATIONAL VEHICLES, & TIRES , COMMERCIAL/IND USTRIAL PREMISES, COMMERC IAL STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTAT ION FACILITIES, EATING ESTABLISHMENTS , EGG PACK ING PLANTS, FEED MILLS/FEED PROCESSING PLANTS , FOOD PROCESSING PLANT, GREENHOUSE

- EMPTY , GREENHOUSES

- IN USE , ANIMAL TREATMENT ( HORSES ), HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DO MESTIC DWELLINGS, LAWNS AND TURF , PATHS/PATIOS , SOLID WASTE SITES, SEED HOUSES/STORES/STORAGE AREAS 26 45385

- 94 IGUANA ANIMAL KENNELS/SLEEPING QUARTERS , COMMERCIAL/INDUSTR IAL PREMISES, COMMERCIAL STORAGES/WAREHOUSE S, COMMERCIAL TRANSPORT ATION FACILITIES, DRAINAGE SYSTEMS , EATING ESTABLISHMENTS, FOOD PROCESSING PLANT, FOOD STOR ES/MARKETS/SUPERMARKETS, ANIMAL TREATMENTS ( HORSES ), HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DOM ESTIC DWELLING, ORNAMENTAL LAWNS AND TURF , SOLID WASTE SITES, SEED HOUSES/STORES/STORAGE A REAS 30.6 53883

- 137 CYPER AG II AGRICULTURAL FOOD CROPS 24.8 53883

- 247 CYPER TC II BARNS , COMMERCIAL/INDUSTR IAL PREMISES, HOUSEHOLD/DOMESTIC DWELLINGS , INDUSTRIAL/CONSTRUCTION AREAS, NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , NONAGRICULTURAL UNCULTIVATED AREAS/SOILS , ORNAMENTAL AND/OR SHADE TREES / WOODY SHRUBS AND VINES , L AWNS AND TURF , PATHS/PATIOS , SOLID WASTE SITES, RESIDENTIAL LAWNS , UTILITY POLES / RIGHT

- OF

- WAY WOOD PROTECTION TREATMENT 25.4 53883

- 27 VIPER INSECTICIDE CONCENTRATE BARNS , BATHROOM PREMISES/HARD SU RFACES , COMMERCIAL/IND USTRIAL PREMISES, COMMERCIAL STORAGES/WAREHOUSES , COMMERCIAL TRANSPORT ATION FACILITIES, DRAINAGE SYSTEMS , EATING ESTABLISHMENTS, FENCEROWS , F OOD PROCESSING PLANT , GREENHOUSES

- IN USE , HOSPITALS/MEDICAL INSTITUT IONS, HOUSEHOLD/DOMESTIC DWELLINGS, ORNAMENTAL HERBACEOUS PLANTS / WOODY SHRUBS AND VINES , LAWNS AND TURF , SOLID WASTE SITES, WOOD PROTECTION TREATMENT 26 53883

- 278 CYPER LO BARNS , COMMERCIAL/INDUSTRIAL LAWNS , COMMERCIAL/ INDUSTRIAL PREMISES , COMMERCIAL STORAGES/WAREHOU SES, COMMERCIAL TRANSPORT ATION FACILITIES, EATING ESTABLISHMENTS , FOOD PROCESSING PLANT, FOOD STOR ES/MARKETS/SUPERMARKETS, GREENHOUSE

- EMPTY , HOSPITALS/MEDICAL INSTITUTIONS, HOUSEHOLD/DOMESTIC DWELLINGS , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , ORNAMENTAL A ND/OR SHADE TREES / WOODY SHRUBS AND VINES , LAWNS AND TURF , PATHS/PATIOS , SOLID WASTE SITES, RESIDENTIAL LAWNS , SHIPS AND BOATS , UTILITY POLES / RIGHT

- OF

- WAY , WOOD PROTECTION TREATMENT 25.4 53883

- 92 CYPER TC INSECTICIDE BARNS , COMMERCIAL/INDUSTR IAL PREMISES, HOUSEHOLD/DOMESTIC DWELLINGS , INDUSTRIAL / CONSTRUCTION AR EAS, NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , ORNAMENTAL

### 24 AND/OR SHADE TREES / WOODY SHRUBS AND VINES , LAWNS AND TURF , PATHS/PATIOS , SOLID WASTE SITES, RESIDENTIAL LAWNS , UTILITY POLES / RIGHT

- OF

- WAY , WOOD PROTECTION TREATMENT TO BUILDINGS/PRODUCTS OUTDOOR 24.8 70506

- 19 UP

- CYDE PRO 2.0 EC TERMITICIDE/INSECTICID E BARNS , BATHROOM PREMISES/HARD SURFACES , COMMERCIAL/INDUSTR IAL PREMISES, COMMERC IAL STORAGES/WAREHOUSES, DRAINAGE SYSTE MS , EATING ESTABLI SHMENTS, ENCEROWS/HEDGEROWS , FOOD PROCESSING PLANT, FOOD STOR ES/MARKETS/SUPERMARKETS, GREENHOUSE

- EMPTY , HOSPITAL S/MEDICAL INSTITUTIONS, HOUSEHOLD/DOMESTIC DWELLINGS , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , ORNAMENTAL AND/OR SHADE T REES / WOODY SHRUBS AND VINES , SOLID WASTE SITES, RESIDENTIAL LAWNS WOOD PROTECTION TREATMENT 30.6 70506

- 20 UP

- CYDE 2.5 EC AGRICULTURAL INSECTICIDE AGRICULTURAL FOOD CROPS

30.6 70506

- 21 CYPERMETHRIN 2.5 EC TERMITICIDE/INSECTICID E BARNS , BATHROOM PREMISES/HARD SURFACES , COMMERCIAL/INDUSTR IAL PREMISES, COMMERC IAL STORAGES/WAREHOUSES, COMMERCIAL TRANSPORT ATION FACILITIES, DRAINAGE SYSTEMS , EATING ESTABLISHMENTS, FOOD PROCESSING PLANT, GREENHOUSES

- IN USE , HOSPITALS/MEDICAL INSTITUT IONS, HOUSEHOLD/DOMESTIC DWELLINGS , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , RIGHTS

- OF

- WAY , SOLID WASTE SITES, RESIDENTIAL LAWNS , WOOD PROTECTION TREATMENT 26 73049

- 154 CYPER

- ACTIVE 2.14 EC ANIMAL KENNELS/SLEEPING QUART ERS, AUTOMOBILES, TAXIS, LIMOUSINES, RECREATIONAL VEHICLES, & TIRES , BARNS , COMMERCIAL/INDUSTRIAL LAWNS , COMMERCIAL/INDUSTRIAL PREMISES , COMMERCIAL S TORAGES/WAREHOUSES , COMMERCIAL TRANSPO RTATION FACILITIES, EATING ESTABLISHMENTS , EGG HANDLING ROOMS, FEED MILLS/FEED PROCESSING PLAN TS , FOOD STOR ES/MARKETS/SUPERMARKETS, GREENHOUSE

- EMPTY , HOSPITALS/MEDICAL INSTITUTIONS, HOUSEHOLD/DOMESTIC DWELLINGS , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / NONFLOWERING PLANTS / WOODY SHRUBS AND VINES , LAWNS AND TURF , PATHS/PATIOS , PET LIVING/SLEEPING QUARTERS , RECREATION AREA LAWNS , SOLID WASTE SITES, RESIDENTIAL LAWNS , SEED HOUSES/STORES/STORAGE , SHIPS AND BOATS 30.6 83222

- 7 CYPER G

- AG 2.5 EC AGRICULTURAL FOOD CROPS
Zeta
- Cypermethrin Products and Use Sites. F ormulation Type % Active Ingredient EPA R eg . N o . R egistered Product Name Registered Use Sites

DISPERSIBLE FLOWABLE (DF) 6.7 279

- 3333 F6305 WDG INSECTICIDE COTTON
E MULSION, OIL IN WATER (EW) 0.075 279

- 9535 F6141 EW INSECTICIDE HOUSEHOLD/DOMESTIC DWELLINGS , LAWNS AND TURF , ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / NONFLOWERING PLANTS / WOODY SHRUBS AND VINES , PATHS/PATIOS , RESIDENTIAL LAWNS/PLANST AND WEGETABLES GRANULAR (R) 0.344 279

- 3297 0.344% F0570 OTC GRANULAR INSECTICIDE ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / NONFLOWERING PLANTS / WOODY SHRUBS AND VINES , RESIDENTIAL LAWNS 0.258 279

- 3298 0.258% F0570 OTC GRANULAR INSECTICIDE ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / NONFLOWERING PLANTS / WOODY SHRUBS AND VINES , RESIDENTIAL LAWNS 0.129 279

- 3299 0.129% F0570 OTC GRANULAR INSECTICIDE ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / NONFLOWERING PLANTS / WOODY SHRUBS AND VINES , RESIDENTIAL LAWNS 0.150 279

- 3300 F0570 0.15 GRANULAR INSECTICIDE COMMERCIAL/INDUSTRIAL LAWNS , COMMERCIAL/ INDUSTRIAL PREMISES , ELECTRICAL SUPPLIES/EQUIPMENT , HOUSEHOLD/DOMESTIC DWELLINGS , LAWNS AND TURF , RECREATIONAL AREAS LAWNS , RESIDENTIAL LAWNS

### 25 0.05 279

- 3342 F6131 G INSECTICIDE COMMERCIAL/INDUSTRIAL LAWNS , COMMERCIAL/ INDUSTRIAL PREMISES , ELECTRICAL SUPPLIES/EQUIPMENT , GREENHOUSE

- EMPTY , GREENHOUSES

- IN USE , HOUSEHOLD/DOMESTIC DWELLINGS , INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR) , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , RIGHTS

- OF

- W AY/FENCEROWS/HEDGEROWS , NONAGRICULTURAL UNCULTIVATED AREAS/SOILS , ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / SHRUBS AND VINES , RECREATIONAL AREAS , RESIDENTIAL LAWNS 0.05 279

- 3343 F6132 G INSECTICIDE COMMERCIAL/INDUSTRIAL LAWNS , COMMERCIAL/ INDUSTRIAL PREMISES , ELECTRICAL SUPPLIES/EQUIPMENT , GREENHOUSE

- EMPTY , GREENHOUSES

- IN USE , HOUSEHOLD/DOMESTIC DWELLINGS , INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR) , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , RIGHTS

- OF

- W AY/FENCEROWS/HEDGEROWS , NONAGRICULTURAL UNCULTIVATED AREAS/SOILS , OR NAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / SHRUBS AND VINES , RECREATIONAL AREAS , RESIDENTIAL LAWNS 0.05 279

- 3344 F6133 G INSECTICIDE COMMERCIAL/INDUSTRIAL LAWNS , COMMERCIAL/ INDUSTRIAL PREMISES , ELECTRICAL SUPPLIES/EQUIPMENT , GREENHOUSE

- EMPTY , GREENHO USES

- IN USE , HOUSEHOLD/DOMESTIC DWELLINGS , INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR) , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , RIGHTS

- OF

- W AY/FENCEROWS/HEDGEROWS , NONAGRICULTURAL UNCULTIVATED AREAS/SOILS , ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / SHRUBS AND VINES , RECREATIONAL AREAS , RESIDENTIAL LAWNS 0.05 279

- 3345 F6135 G INSECTICIDE COMMERCIAL/INDUSTRIAL LAWNS , COMMERCIAL/ INDUSTRIAL PREMISES , ELECTRICAL SUPPLIES/EQUIPMENT , GREENHOUSE

- EMPTY , GREENHOUSES

- IN USE , HOUSEHOLD/DOMESTIC DWELLINGS , INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR) , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , RIGHTS

- OF

- W AY/FENCEROWS/HEDGEROWS , NONAGRICULTURAL UNCULTIVATED AREAS/SOILS , ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / SHRUBS AND VINES , RECREATIONAL AREAS , RESI DENTIAL LAWNS 0.029 279

- 3352 F6130 G INSECTICIDE NONAGRICULTURAL FOOD CROPS, ORNAMENTAL AND/OR SHADE TREES/HERBACEOUS PLANTS/NONFLOWERING PLANTS/WOODY SHRUBS AND VINES, RESIDENTIAL LAWNS 0.05 279

- 9547 F6132 GC GRANULAR INSECTICIDE COMMERCIAL/INDUSTRIAL LAWNS , COMMERCIAL/ INDUSTRIAL PREMISES , ELECTRICAL SUPPLIES/EQUIPMENT , GREENHOUSE

- EMPTY , GREENHOUSES

- IN USE , HOUSEHOLD/DOMESTIC DWELLINGS , INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR) , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , RIGHTS

- OF

- W AY/FENCEROWS/HEDGEROWS , NONAGRICULTURAL UNCULTIVATED AREAS/SOILS , ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / SHRUBS AND VINES , RECREATIONAL AREAS , RESIDENTIAL LAWNS , GOLF COURSE TURF , GREENHOUSE

- EMPTY , ORNAMENTAL SOD FARM (TURF) 0.05 279

- 9552 F6139

- 2 INSECTICIDE COMMERCIAL/INDUSTRIAL LAWNS , COMMERCIAL/ INDUSTRIAL PREMISES , ELECTRICAL SUPPLIES/EQUIPMENT , GREENHOUSE

- EMPTY , GREENHOUSES

- IN USE , HOUSEHOLD/DOMESTIC DWELLINGS , INDUSTRIAL / CONSTRUCTION AREAS (OUTDOOR) , NONAGRICULTURAL OUTDOOR BUILDING S/STRUCTURES , RIGHTS

- OF

- W AY/FENCEROWS/HEDGEROWS , NONAGRICULTURAL UNCULTIVATED AREAS/SOILS , ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / SHRUBS AND VINES , RECREATIONAL AREAS , RESIDENTIAL LAWNS DUST (D) 0.075 279

- 3259 ZETA

- CYP DUST INSECTICIDE AIRPORTS/LANDING FIELDS , BATHROOM PREMISES/HARD SURFACES , COMMERCIAL/INDUSTRIAL LAWNS , COMMERCIAL/ INDUSTRIAL PREMISES , COMMERC IAL STORAGES/WAREHOUSES, COMMERCIAL TRANSPORTATION FACILITIES

- NONFEED/NONFOOD , EATING ESTABLISHMENTS , ELECTRICAL SUPPLIES/EQUIPME NT , FOOD PROCESSING PLANT PREMISES , G REENHOUSE

- EMPTY , GREENHOUSES

- IN USE , HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DOMESTIC DWELLINGS , ORNAMENTAL AND/OR SHADE TREES , ORNAMENTAL HERBACEOUS PLANTS / NONFLOWERING PLANTS / WOODY SHRUBS AND VIN ES , PATHS/PATIOS , RECREATIONAL AREAS , RECREATION AREA LAWNS , SOLID WASTE CONTAINERS , RESIDENTIAL LAWNS , SEWAGE SYSTEMS 0.075 39039

- 9 Y

- TEX PYTHON DUST LIVESTOCK INSECTICIDE ANIMAL TREATMENT

### 26 READY

- TO

- USE ( RTU ) 279

- 3347 0.35 F6570 EW MASTER INSECTICIDE DECIDUOUS FRUIT TREES , HOUSEHOLD/DOMESTIC DWELLINGS , NONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , LAWNS AND TUR F, ORNAMENTAL AND/OR SHADE TREES / GROUND COVER / HERBACEOUS PLANTS / NONFLOWERING PLANTS / WOODY SHRUBS AND VINES , PATHS/PATIOS , RESIDENTIAL LAWNS , ROSE 0.35 279

- 3348 F6570 EW PRO INSECTICIDE BARNS, BATHROOM PREMISES/HARD SURFACES , COMMERCIAL/INDUSTRIAL LAWNS , COMMERCIAL INDUSTRIAL PREMISES , COMMERCIAL TRANSPORTATION FACILITIES , DAIRY FARM MILK HANDLING FACILITIES/EQUIPMENT , DEC ID UOUS FRUIT TREES, DRAINAGE SYSTEMS , EATING ESTABLISHMENTS , EGG PACKING PLANTS, FOOD PROCESSING PLANT PREMISES, GREENHOUSE

- EMPTY , GREENHOUSES

- IN USE , HOSPITALS/MEDICAL INSTITUTIONS HOUSEHOLD/DOMESTIC DWELLINGS , MEAT PROCESSING PLANT PREMISES , ORNAMENTAL A ND/OR SHADE TREES / GROUND COVER / HERBACEOUS PLANTS / NONFLOWERING PLANTS / ORNAMENTAL WOODY SHRUBS AND VINES , PATHS/PATIOS , POULTRY PROCESSING PLANT, SOLID WASTE SITES, RESIDENTIAL LAWNS , TREE NUTS 0.04 279

- 3349 F6578 EW INSECTICIDE HOUSEHOLD/DOMESTIC DWELLINGS, ORNAMENTAL AND/OR SHADE TREES, ORNAMENTAL GROUND COVER, ORNAMENTAL HERBACEOUS PLANTS, ORNAMENTAL NONFLOWERING PLANTS, ORNAMENTAL WOODY SHRUBS AND VINES, PATHS/PATIOS, SOLID WASTE SITES, RESIDENTIAL LAWNS, ROSE 0.013 279

- 9534 F6129 EW INSECTICIDE GARDEN AND VEGETEABLES NONAGRICULTURAL FOOD CROPS, HOUSEHOLD/DOMESTIC DWELLINGS, ORNAMENTAL AND/OR SHADE TREES, RESIDENTIAL LAWNS IMPREGNATED MATERIAL (IMPR) 10 39039

- 11 PYTHON MAGNUM INSECTICIDE CATTLE EAR TAGS ANIMAL TREATMENT (EAR TAG)

10 39039

- 14 10 YT

- 1601 DOG TAG ANIMAL TREATMENT (COLLAR) 10 39039

- 4 PYTHON INSECTICIDE CATTLE EAR TAGS ANIMAL TREATMENT (EAR TAG)
EMULSIFIABLE CONCENTRATE (EC) 0.75 1021

- 1859 EVERCIDE 28511 FOOD CROPS, AN IMAL KENNELS/SLEEPING QUARTERS, BARNS , COMMERCIAL INDUSTRIAL PREMISES , COMMERCIAL STORAGES/WAREHOUSES PREMISES , DRAINAGE SYSTEMS , EATING ESTABLISHMENTS , EGGPLANT FOOD PROCESSING PLANT PREMISES , GREENHOUSES

- IN USE , HOSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DOMESTIC DWELLINGS , N ONAGRICULTURAL OUTDOOR BUILDINGS/STRUCTURES , ORNAMENTAL AND/OR SHADE TREES/ HERBACEOUS PLANTS / NONFLOWERING PLANTS , PATHS/PATIOS , POULTRY FEEDLOTS , SOLID WASTE SITES, ROSE , SWINE FEEDLOTS , LAWNS AND TURF 18.1 279

- 3125 FURY 1.5 EC INSECTICIDE FOOD CROPS 17.1 279

- 3126 FURY 1.5 EW INSECTICID E FOOD CROPS 17.1 279

- 3243 ZETA

- CYP EW AIRPORTS/LANDING FIELDS , BARNS , BATHROOM PREMISES/HARD SURFACES , COMMERCIAL/INDUSTRIAL PREMISES , COMMERCIAL STORAGES/WAREHOUSES , COMMERCIAL TRANSPORTATION FACILITIESDRAINAGE SYS TEMS , EATING ESTABLISHMENTS , FOOD PROCESSING PLANT PREMISES , GREENHOUSE

- EMPTY , GREENHOUSES

- IN USE , H OSPITALS/MEDICAL INSTITUTIONS (HUMAN/VETERINARY) , HOUSEHOLD/DOMESTIC DWELLINGS , MULCH , NONAGRICULTURAL RIGHTS

OF

- WAY/FENCEROWS/HEDGEROWS , ORNAMENTAL AND/OR SHADE TREES / WOODY SHRUBS AND VINES , PATHS/PATIOS , SOLID WASTE SITES, RESIDENTIAL LAWNS , WOOD PROTECTION TREATMENT 9.2 279

- 3248 Z

- C YPE 0.8 EW I NSECTICIDE FOOD CROPS
9.6 279

- 3249 Z

- CYPE 0.8 EC INSECTICIDE FOOD CROPS, TERRESTIAL FEED
17.1 279

- 3289 ZETA

- CYP 1.5EW OTC INSECTICIDE HOUSEHOLD/DOMESTIC DWELLINGS OUTDOOR PREMISES , ORNAMENTAL WOODY SHRUBS AND VINES
3.75 279

- 3315 HERO INSECTICIDE FOOD CROPS, TERRESTIAL FEED 9.6 279

- 3327 ZETA

- CYPE 0.8EC INSECTICIDE FOOD CROPS, TERRESTIAL FEED/RENGELAND, ORNAMENTAL AND/OR SHADE TREES ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / WOODY SHRUBS AND VINES 9.2 279

- 3328 ZETA

- CYPE 0.8EC FOOD CROPS, TERRESTIAL FEED

### 27 INSECTICIDE 3.24 279

- 3329 F6126 EW INSECTICIDE FOOD CROPS, TERRESTIAL FEED 0.75 279

- 3362 F6138

- 1 ZW INSECTICIDE ANIMAL HOUSING PREMISES , ANIMAL KENNELS/SLEEPING QUARTERS , BARNS , COMMERCIAL/ INDUSTRIAL PREMISES/COMMERCIAL/ INDUSTRIAL PREMISES , COMMERC IAL STORAGES/ WAREHOUSES, DECIDUOUS FRUIT TREES , F OOD/GROCERY/MARKETING/STORAGE/DISTRIBUTION FACILITY PREMISE S, HOUSEHOLD/DOMESTIC DWELLINGS , LIVESTOCK FEED LOTS , ORNAMENTAL AND/OR SHADE TREES / GROUND COVER / HERBACEOUS PLANTS / NONFLOWERING / PLANTS / WOODY SHRUBS AND VINES , PATHS/PATIOS , RECREATIONAL AREAS , SOLID WASTE SITES , RESIDENTIAL LAWNS , TREE NU TS , UTILITIES , UTILITY POLES , RIGHT

- OF

- WAY 0.75 279

- 3363 F6138

- 1 ZW FHE INSECTICIDE ANIMAL HOUSING PREMISES, ANIMAL KENNELS/SLEEPING QUARTERS , BARNS , COMMERCIAL/INDUSTRIAL PREMISES , COMMERCIAL STORAGES/WAREHOUSES , DECIDUOUS FRUIT TREES , FOOD STORES/MARKE TS/SUPERMARKETS , HOUSEHOLD/DOMESTIC DWELLINGS , LIVESTOCK FEED LOTS , ORNAMENTAL AND/OR SHADE TREE / GROUND COVER / HERBACEOUS P LANTS / NONFLOWERING PLANTS / WOODY SHRUBS AND VINES , PATHS/PATIOS , RECREATIONAL AREAS SOLID WASTE SITES (OUTDOOR) , RESIDENTIAL LAWNS , T REE NUTS , UTILITIES , UTILITY POLES / RIGHT

OF

- WAY 8.2 279

- 3380 F9043 EC INSECTICIDE FOOD CROPS 9.6 279

- 3381 ZETA

- CYPE 0.8 EC HSL INSECTICIDE FOOD CROPS
9.15 279

- 3426 F9114 EC INSECTICIDE FOOD CROPS/TERRESTIAL FEED, ORNAMENTAL AND/OR SHADE TREES / HERBACEOUS PLANTS / SOD FARM (TURF) / WOODY SHRUBS AND VINES 3.08 279

- 9545 F9047

- 2 EC INSECTICIDE AGRICULTURAL FOOD CROPS

### Page 28 of 33 Attachment 4
. International Residue Limit (IRL) Status

International Residue Limits Cypermethrin (PC Code 109702) and Zeta

- Cypermethrin (PC Code 129064 ) Summary of US and International Tolerances and Maximum Residue Limits Residue Definition : US Canada Mexico Codex 1 2 40 CFR 180. 418(a)( 1 ) Plant/Livestock: cypermethrin (±)alpha cyano
- (3

- phenoxyphenyl)methyl(±)cis,trans

3(2,2

- dichloroethenyl

- 2,2

- dimethylcyclopropanecarboxylate ( RS )

- α
- cyano
- 3

- phenoxybenzyl (1 RS , 3 RS )

- (1 RS , 3 SR )

- 3

- (2,2

- dichlorovinyl)

- 2,2

- dimethylcyclopropanecarbo xylate cypermethrin (sum of isomers). The residue i s fat

- soluble.



### Commodity Tolerance (ppm) /Maximum Residue Limit (mg/kg) US Canada Mexico Codex 1 2 Brassica, head and stem, subgroup 5A 2.0 0.5 broccoli, Brussels sprouts, cabbages, cauliflower 1 Brassica (cole or cabbage) vegetables, head cabbage, flowerhead Brassicas Brassica, leafy greens, subgroup 5B 14.0 0.7 leafy vegetables Cattle, fat 1.0 Cattle, meat 0.2 2 meat (from mammals other than marine mammals) (fat) 4 Cattle, meat byproducts 0.05 0.05 (*) edible offal (mammalian) 4 Cotton, gin byproducts 11.0 Cotton, undelinted seed 0.5 0.1 oilseed Egg 0.05 0.01 (*) Goat, fat 1.0 Goat, meat 0.2 2 meat (from mammals other than marine mammals) (fat) 4 Goat, meat byproducts 0.05 0.05 (*) edible offal (mammalian) 4 Hog, fat 0.1 Hog, meat 0.05 2 meat (from mammals other than marine mammals) (fat) 4 Horse, fat 1.0 Horse, meat 0.2 2 meat (from mammals other than marine mammals) (fat) 4 Horse, meat byproducts 0.05 0.05 (*) edible offal (mammalian) 4 Lettuce, head 4.0 0.7 leafy vegetables Milk, fat (reflecting 0.10 in whole milk) 2.5 0.5 milk fats 0.05 milk

### Cypermethrin and Zeta

- Cypermethrin Registration Review Scoping Document

Page 29 of 33 Summary of US and International Tolerances and Maximum Residue Limits Residue Definition : US Canada Mexico Codex 1 2 Onion, bulb 0.1 0.1 dry bulb onions 0.01 (*) Onion, green 6.0 Pecan 0.05 Poultry, fat 0.05 Poultry, meat 0.05 0.1 (fat) Sheep, fat 1.0 Sheep, meat 0.2 2 meat (from mammals other than marine mammals) (fat) 4 Sheep, meat byproducts 0.05 0.05 (*) edible offal (mammalian) 4 180. 418 (a)( 2 ) Z

- cypermethrin (S

- cyano(3

- phenoxyphenyl) methyl (±))(cis

- trans 3

- (2,2

- dichloroethenyl)

- 2,2 dimethylcyclopropanecarbox ylate and its inactive R

isomers 

### US Canada 

### Same as above Mexico Codex 2 

### Same as above 3

Alfalfa, hay 15.0 30 alfalfa fodder Alfalfa, forage 5.00 Alfalfa, seed 0.50 Almond, hulls 6 Animal feed, nongrass, group 18, forage 8 Animal feed, nongrass, group 18, hay 40 Beet, sugar, roots 0.05 0.1 sugar beet Beet, sugar, tops 0.20 Berry group 13 0.8 0.2 strawberries 0.07 strawberry Borage, seed 0.2 0.1 oilseed Brassica, head and stem, subgroup 5A 2.00 0.5 broccoli, Brussels sprouts, cabbages, cauliflower 1 Brassica (cole or cabbage) vegetables, head cabbage, flowerhead Brassicas Brassica, leafy greens, subgroup 5B 14.0 0.7 leafy vegetables Cabbage 2.00 0.5 1 Brassica (cole or cabbage) vegetables, head cabbage, flowerhead Brassicas Castor oil plant, refined oil 0.4 0.1 oilseed Castor oil plant, seed 0.2 Cattle, fat 1.00 Cattle, meat 0.2 2 meat (from mammals other than marine mammals) (fat) 4 Cattle, meat byproducts 0.05 0.05 (*) edible offal (mammalian) 4

### Cypermethrin and Zeta

- Cypermethrin Registration Review Scoping Document

Page 30 of 33 Summary of US and International Tolerances and Maximum Residue Limits Residue Definition : US Canada Mexico Codex 1 2 Chinese tallowtree, refined oil 0.4 0.1 oilseed Chinese tallowtree, seed 0.2 Cilantro, leaves 10 Citrus, dried pulp 1.8 2 citrus fruits Citrus, oil 4.0 Corn, field, forage 0.20 Corn, field, grain 0.05 0.3 cereal grains (except rice, barley, oats, rye and wheat C 3 Corn, field, stover 3.00 10 straw and fodder (dry) of cereal grains Corn, pop, grain 0.05 Corn, pop, stover 3.00 10 straw and fodder (dry) of cereal grains Corn, sweet, forage 15.0 Corn, sweet, kernel plus cob with husks removed 0.05 0.05 (*) Corn, sweet, stover 15. 0 10 straw and fodder (dry) of cereal grains Cotton, undelinted seed 0.5 0.1 oilseed Crambe, seed 0.2 Cuphea, seed 0.2 Echium, seed 0.2 Egg 0.05 0.01 (*) Euphorbia, refined oil 0.4 0.1 oilseed Euphorbia, seed 0.2 Evening primrose, refined oil 0.4 Evening primrose, seed 0.2 Flax, seed 0.2 Food commodities/feed commodities (other than those covered by a higher tolerance as a result of use on growing crops) in food/feed handling establishments 0.05

Fruit, citrus, group 10 0.35 1.0 citrus fruits 2 citrus fruits Fruit, pome, group 11 2 1.0 apples 0.5 pears 0.7 pome fruits Fruit, stone, group 12 1 0.2 peaches/nectarines 2 stone fruits Goat, fat 1.00 Goat, meat 0.2 2 meat (from mammals other than marine mammals) (fat) 4 Goat, meat byproducts 0.05 0.05 (*) edible offal (mammalian) 4 Gold of pleasure, seed 0.2 0.1 oilseed Grain, aspirated fractions 10.0

### Cypermethrin and Zeta

- Cypermethrin Registration Review Scoping Document

Page 31 of 33 Summary of US and International Tolerances and Maximum Residue Limits Residue Definition : US Canada Mexico Codex 1 2 Grape 2 0.5 0.2 0.5 dried grapes (=currants, raisins and sultanas) Grass, forage, fodder, and hay, group 17, forage 10 Grass, forage, fodder and hay, group 17, hay 35 10 straw and fodder (dry) of cereal grains Hare's

- ear mustard, seed 0.2 0.1 oilseed Hog, fat 0.1 Hog, meat 0.05 2 meat (from mammals other than marine mammals) (fat) 4 Horse, fat 1.00 Horse, meat 0.2 2 meat (from mammals other than marine mammals) (fat) 4 Horse, meat byproducts 0.05 0.05 (*) edible offal (mammalian) 4 Jojoba, refined oil 0.4
0.1 oilseed Jojoba, seed 0.2 Lesquerella, seed 0.2 Lunaria, seed 0.2 Meadowfoam, seed 0.2 Milk, fat (reflecting 0.10 in whole milk) 2.50 0.5 milk fats 0.05 milks 4 Milkweed, seed 0.2 0.1 oilseed Mustard, seed 0.2 Niger seed, refined oil 0.4 Niger seed, seed 0.2 Nut, tree, group 14 0.05 Oil radish, seed 0.2 0.1 oilseed Okra 0.2 0.5 Onion, bulb 0.10 0.1 dry bulb onions 0.01 (*) Onion, green 3.00 Pea and bean, dried shelled, except soybean, subgroup 6C 0.05 0.5 beans 0.05 (*) pulses Pea and bean, succulent shelled, subgroup 6B 0.1 0.5 beans 0.7 legume vegetables Peanut 0.05 Pecan 0.05 Poppy, seed 0.2 0.1 oilseed Poultry, fat 0.05 Poultry, meat 0.05 0.1 (fat) Rapeseed 0.2 0.1 oilseed Rice, grain 1.50 2 rice Rice, hulls 6.00 Rice, straw 2.00 10 straw and fodder (dry) of cereal grains Rice, wild, grain 1.5

### Cypermethrin and Zeta

- Cypermethrin Registration Review Scoping Document

Page 32 of 33 Summary of US and International Tolerances and Maximum Residue Limits Residue Definition : US Canada Mexico Codex 1 2 Rose hip, refined oil 0.4 0.1 oilseed Rose hip, seed 0.2 Safflower, seed 0.2 Sesame, seed 0.2 Sheep, fat 1.00 Sheep, meat 0.2 2 meat (from mammals other than marine mammals) (fat) 4 Sheep, meat byproducts 0.05 0.05 (*) edible offal (mammalian) 4 Sorghum, grain, forage 0.1 Sorghum, grain, grain 0.5 0.3 cereal grains (except rice, barley, oats, rye and wheat Acz 3 Sorghum, grain, stover 5.0 10 straw and fodder (dry) of cereal grains Soybean, seed 0.05 0.05 (*) pulses Stokes aster, refined oil 0.4 0.1 oilseed Stokes aster, seed 0.2 Sugarcane, cane 0.60 0.2 sugar cane Sunflower, refined oil 0.5

0.1 oilseed Sunflower, seed 0.2 Sweet rocket, seed 0.2 Tallowwood, refined oil 0.4 Tallowwood, seed 0.2 Tea oil plant, refined oil 0.4 Tea oil plant, seed 0.2 Turnip, greens 14 Vegetable, cucurbit, group 9 0.2 0.07 Fruiting vegetables, cucurbits Vegetable, fruiting, group 8 0.2

0.3 tomatoes 0.03 eggplant 0.5 okra 2 peppers chili 10 peppers chili, dried 0.1 peppers, sweet (including pimento or pimiento) 0.2 tomato Vegetable, leafy, except brassica, group 4 10.0 1.0 celery 0.7 leafy vegetables Vegetable, legume, edible podded, subgroup 6A 0.5 0.5 beans 0.7 legume vegetables Vegetable, root and tuber, group 1, except sugar beet 0.1 0.01 (*) root and tuber vegetables ( Except sugar beet ) Vernonia, refined oil 0.4 0.1 oilseed Vernonia, seed 0.2 Wheat, forage 3.0 Wheat, grain 0.2 2 Po C 5 wheat bran, unprocessed PoP C 3

3

### Cypermethrin and Zeta

- Cypermethrin Registration Review Scoping Document

Page 33 of 33 Summary of US and International Tolerances and Maximum Residue Limits Residue Definition : US Canada Mexico Codex 1 2 Wheat, hay 6.0 10 straw and fodder (dry) of cereal grains Wheat, straw 7.0 MRLs with NO US equivalent Artichoke, globe 0.1 Asparagus 0.01 (*) (proposed) Barley 2 Po C 3 Bean fodder 2 C 3 Carambola 0.2 Coffee beans 0.05 (*) Durian 1 Leek 0.05 Litchi 2 Longan 1 Mango 0.7 Oats 2 Po C 3 Olives 0.05 (*) Olive oil, refined 0.5 Olive oil, virgin 0.5 Papaya 0.5 Pea hay or pea fodder (dry) 2 Poultry, edible offal of 0.05 (*) Rye 2 Po C 3 Tea, green, black (black, fermented and dried) 20

Completed: M. Negussie; 01/17/2012 1 Mexico adopts US tolerances and/or Codex MRLs for its export purposes.

2 * = absent at the limit of quantitation ; Po = postharvest treatment, such as treatment of stored grains. PoP = processed postharvest treated commodity, such as processing of treated stored wheat. (fat) = to be measured on the fat portion of the sample. MRLs indicated as proposed have not been finalized by the CCPR and the CAC.

3 Source of data supporting the proposed MRL: a

- alpha

- cypermethrin; c

- cypermethrin; z

- zeta

- cypermethrin; Capital letters show the source of data responsible for the MRL estimate.

4 The MRL accommodates external treatment