UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MEMORANDUM 

Date: 29 March 20 16 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

SUBJECT: Fluensulfonc. Acute and Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessments for the New Use Section 3 Registration Action 

on Root Vegetables (Except Sugar Beet), Tuberous and Corm Vegetables, Leafy 

Vegetables (Except Brassica Vegetables), Brassica (Cole) Leafy Vegetables, 

Fruiting and Cucurbit Vegetables, and Low growing berry Crop 

Groups/Subgroups. 

PC Code: 050410 DP Barcode: D432134 

Decision No.: 50 I 793 Registration No.: 66222-243, 66222-EAE 

Petition No.: 5F835 l Regulatory Action: Section 3 Registration 

Risk Assessment Type: Dietary Case No.: None 

TXR No.: NA CAS No.: 318290-98-1 

MRID No.: NA 40 CFR: §180.680 

FROM: Janet 

Risk Assessment 

V. Cowins, 

Branch 

Ph.D., Chemist{)./.-

If / 

V: ~ 

Health Effects Division (HED, 7509P) ~ 

THROUGH: Dennis McNeilley, Chemist c;;;~ lf1 C--~ ldeliz Negr6n-Encamaci6n, Ph.D., Chemist c..------:: 

Di etary~~posure Science Advisory Council D.~ A5) ,I ~ . ;} j 

Michael 

Risk Assessment 

A. Doherty

Branch 

, Ph.D

Tl 

., Senior Chemist ~ ~ 

Health Effects Division (7509P) 

TO: Rita Kumar/Marianne Lewis/Meredith Laws 

fnvertebrate and Vertebrate Branch 3 

Registration Division (7505P) 

Andrew Ertman/Barbara Madden/Marion Johnson 

Risk Integration, Minor Use, and Emergency Response Branch 

Registration Division (7505P) 

Page I of 19 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: D432 I 34 

Executive Summary 

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments 

were conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food 

consumption data from the U.S. Department of Agriculture's (USDA's) National Health and 

Nutrition Examination Survey, What We Eat in America, (NHANES/WWElA). The analyses 

were conducted in support of a human-health risk assessment for the proposed Section 3 

registration of tluensulfone on root vegetables (except sugar beet). tuberous and corm vegetables, 

leafy vegetables (except brassica vegetables). brassica (cote) leafy vegetables, and low growing 

berry crop group/subgroup 1 B, l C, 4, 5, and I 3-07G, respectively. In addition to this, a label 

amendment was submitted to increase the application rate of fruiting vegetables (group 8-10) and 

cucurbit vegetables (group 9). Therefore, the crops from the previous assessment will also be 

included. Field trial data from root and leafy vegetables exhibited the highest residues of 

fluensulfone in carrot (0.9 ppm), celery (1.0 ppm), head lettuce (0. 1 ppm) and leaf lettuce (0.03 

ppm). 

Acute and chronic dietary exposure analyses were based on high-end estimates of fluensulfone 

residues, l 00% crop treated, and high-end estimates of residues in drinking water. Acute risk 

estimates, as a percentage of the acute population-adjusted dose (aP AD), range from 2.4% for 

youth 13-19 years of age to 9 .3% for all infants, at the 95111 percentile of exposure. The acute 

dietary risk estimate for the general U.S. population is 3.0% aP AD. Chronic risk estimates range 

from 0. 9% of the chronic population-adjusted dose ( cPAD) for youths 13-19 years of age to 

3.9% for all infants. The chronic dietary risk estimate for the general U.S. population is 1.3% 

cP AD. Risk estimates based on screening-level assumptions and tolerance-level residues are 

below HED's level of concern for both exposure durations and for all population subgroups. For 

all estimates, the majority of the exposure is due to residues in drinking water. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOA EL, e.g.) divided by the required uncertainty or safety 

factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: "Available Information on Assessing 

Exposure from Pesticides, A User's Guide;· 2 l-JUN-2000. web link: 

http://www.regulations.gov/#!documentDetail:D=EPA-HQ-OPP-2007-0780-0001 ; or see SOP 

99.6 (20-AUG-1999). 

The most recent dietary risk assessment for Fluensulfone was conducted by Michael A. Doherty 

(I 0 June 2014; 0418204). 

Page 2of 19 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: 0432134 

II. Residue Information 

Tolerances have been established for fluensulfone (40CFR § 180.680) on fruiting and cucurbit 

vegetables, as well as tomato paste. Accompanied by this tolerance establishment, is also a 

Section 18 registration on carrot. These analyses were performed to support the establishment of 

a tolerance for fluensulfone residues inion the aforementioned crops. Fluensulfone is used to 

treat various agricultural crops, commercial turf and sod farms. Following application, 

fluensulfone breaks down to form, primarily, BSA (3,4,4-trifluoro-but-3-ene-1-sulfonic acid) and 

TSA (5-chloro-thiazole-2-sulfonic acid) to such an extent that quantifiable residues of parent 

fluensulfone are typically not expected in harvested commodities. However, in root (carrot) and 

leafy vegetables (except Brassica vegetables) (celery, head, and leaf lettuce), quantifiable 

resid ues of fluensulfone were present. The residue definitions for fluensulfone are summarized in 

Table I. Because of the residue profile, tolerances for fluensulfone are based on analysis of BSA 

only; however, BSA is considered to be of very low toxicity and risk estimates are based on 

residues of the parent compound in foods and on combined residues of fluensulfone, deschlorofluensulfone, and the methyl sulfone metabolite (MeS) in drinking water (0412114; E. Holman; 

27 August 2013). For both the acute and chronic assessments, high end estimates are assumed 

for all crops. Residues in drinking water are discussed in Section IV, below. 

Parent tluensulfone occurs at residue levels well below those of BSA, the residue defined for the 

enforcement of tolerances. Since tolerances do not include fluensulfone itself, HED has used the 

OECD MRL calculation procedures to derive tolerance-equivalent residue levels for 

fluensulfone. For foods where the level of fluensulfone is expected to be below the limit of 

quantification (LOQ). 0.0 I ppm, HED has assumed that residues occur at the LOQ. For foods 

with quantifiable levels of tluensulfone. HED has assumed that residues occur at the toleranceequivalent level. In addition to the new uses requested for fluensulfone, the dietary assessment 

also addresses the label amendments affecting the previously registered uses for the compound. 

Translation of field trial data from representative commodities were used in this assessment 

following the dietary exposure guidance; see HED SOP 2000.1 (12 September 2000). For the 

remaining crops where fluensulfone was less than the LOQ, a screening-level analysis was 

performed based on fluensulfone residues at the limit of quantitation (0.0 l ppm). The drinking 

water estimates for the acute and chronic analysis is provided in Table 3 and discussed in Section 

lY below. An input residue table for selected fluensulfone commodities is provided in Table 2. A 

complete listing of the residues used in the acute and chronic analyses are included in 

Anachment 1. 

Table 1. Summary of Metabolites and Degradates to be included in the Risk Assessment and 

Tolerance Expression 

Matrix 

Residues included in Risk Residues included in Tolerance 

Assessment Expression 

Plants 

Primary Crop Fluensulfone BSA. 

Rotational Crop Fluensulfone BSA. 

Livestock Ruminant None None 

Poultry None None 

Page 3of 19 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: D432 l 34 

Table 1. Summary of Metabolites and Degradates to be included in the Risk Assessment and 

Tolerance Expression 

Matrix Residues included in Risk Residues included in Tole ra nce 

Assessment Expression 

Fluensulfone + Mes· + deschloro- Not Applicable 

Drinking Water fluensulfone, expressed as parent 

equivalent 

Table2. Input Table For Fluensulfone Commodities. 

Commodity Name Crop Group/Subgroup Anticipated Residue Estimatesrrolerance 

Beet, garden, roots IA/ IB 0.01 Beet, garden, roots-babv food 

Burdock IA/I B 0.01 

Carrot 

Carrot-baby food IA/I B 0.90 

Carrot, juice 

Celeriac IA/IB 0.0 1 

Chicory, roots IA/ IB 0.90 

Ginseng, dried IA/ IB 0.90 

Horseradish IA/I B 0.90 

Parsley, turnip rooted IA/ IB 0.90 

Parsnip INIB 0.90 

Parsn ip-babyfood 

Radish, roots IA/ IB 0.01 

Radish, Oriental, roots IA/ IB 0.0 1 

Rutabaga IA/ IB 0.01 

Salsify, roots IA/I B 0.90 

Turnip, roots IA/18 0.01 

Arrowroot, flour IC/ ID 0.01 

Arrowroot, flour-babyfood 

Artichoke, Jerusalem IC/I D 0.01 

Cassava 0.01 

Cassava-baby food IC/ ID 

Dasheen, corm IC/ID 0.0 1 

Ginger 

G inger-babyfood IC/ ID 0.01 

Ginger, dried 

Page 4of19 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: D432 J 34 

Table2. Input Table For Fluensulfone Commodities. 

Commodity Name Crop Group/Subgroup Anticipated Residue Estimatesffolerance 

Potato, chips 

Potato, dry (granu lestnakes) 

Potato, dry (granulestnakes)-

baby food 

Potato, flour IC 0.01 

Potato, llour-babyfood 

Potato, tuber, w/peel 

Potato-tuber, w/peel-babyfood 

Potato, ruber, w/o peel 

Potato, tuber, w/o peelbabvfood 

Sweet potato IC/ ID 0.0 1 

Sweet eotato-bab~food 

Tanier, corm I IC/ ID 0.0 1 

Tumeric IC/ID 0.0 1 

Yam, true 

Yam bean IC/ID 0.01 

Beet, garden, tops 2 0.01 

Chicory, tops 2 0.01 

Dasheen, leaves 2 0.0 1 

Radish, tops 2 0.0 1 

Radish, Oriental, tops 2 0.0 1 

Salsify, tops 2 0.01 

Amaranth, leafy 4A 0.0 1 

Arugula 4A I 0.01 

Chysantheum, garland 4A 0.01 

Cress, garden 4A 0.0 1 

Cress, upland 4A 0.01 

Dandelion, leaves 4A 0.01 

Endive 4A 0.0 1 

Lettuce, head 4A 0.03 

Lettuce, leaf 4A 0. 10 

Parsely, leaves 4A 0.01 

Radicchio 4A 0.03 

Spinach 4A 0.01 Spinach-babvfood 

Cardoon 48 0.0 1 

Celery 

Celery-baby food 48 1.0 

Cele1)'., juice - Celtuce 48 1.0 

Fennel, Florence 48 1.0 

Rhubarb I 48 1.0 

Swiss chard 48 1.0 

Broccoli 

Broccol i-babyfood SA 0.01 

Broccoli, Chinese 

Page 5of 19 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: D432134 

Table2. Input Table For Fluensulfooe Commodities. 

Commodity Name Crop Group/Subgroup Anticipated Residue Estimatestrolerance 

Brussels sprouts SA 0.01 

Cabbage 

Cabbage, Chinese, napa SA 0.01 

Cabbage, Chinese, mustard 

Cauliflower 5A 0.01 

Kohlrabi 5A 0.01 

Broccoli raab 5B I 0.01 

Cabbage, Chinese, bok choy I 58 0.0 1 

Collards SB 0.0 1 

Kale SB 0.01 

Mustard greens 5B 0.01 

Rape greens 50 0.01 

Turnip, greens SB 0.01 

Tomatillo 8A 0.01 

Tomato 

Tomato-babyfood 

Tomato, paste 

Tomato, paste-babyfood 

Tomato, puree 8A 0.01 

Tomato, puree-babyfood 

Tomato, dried 

Tomato, dried-babyfood 

Tomato, juice 

Tomato. Tree 

E!.?.!.?.o lant 8B/8C 0.01 

Okra 8B/8C 0.01 

Pepper, bell 

Pepper, bell-babyfood 88 0.01 

Pepper, bell, dried 

Pepper, bell, dried-babvfood 

Pepper, nonbell 

Pepper, nonbell-babyfood 8B/8C 0.01 

Peooer, nonbell, dried 

Cantalouee 9A 0.01 

Honeydew melon 9A 0.01 

Watennelon 9A 0.01 

Watennelon. juice 

Balsam pear 9B 0.01 

Chayote, fruit 9B 0.01 

Chinese waxgourd 9B I 0.01 

Cucumber 9B 0.01 

Pumpkin 9B 0.01 

Pumpkin, seed 

Squash, summer 98 0.01 

Squash, summer-babvfood 

Squash, winter 98 0.01 

Squash, winter-babyfood I 

Page 6 of 19 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: D432134 

Table2. Input Table For Fluensulfone Commodities. 

Commodity Name Crop Group/Subgroup Anticipated Residue Estimatesffolerance 

Cranberry 

Cranberry-baby food 

Cranberry, dried 13G 0.01 

Cranberry, juice 

Cranberry, iuice-babyfood 

Strawberry 

Strawberry-babyfood 13G 0.01 

Strawberry, juice 

Strawberry, juice-babyfood 

Water, direct, all sources NIA Acute = 0.0776 ppm 

Water, indirect, all sources Chronic = 0.0525 ppm 

Page 7of 19 
Ill. Percent Crop Treated Information 

Percent crop treated information was not used in either the acute or chronic analysis (i.e. 100% 

crop treated assumed). 

IV. Drinking Water Data 

Estimates of tluensulfone residues of concern in drinking water were provided by the 

Environmental Fate and Effects Division (EFED) in a memo titled "Fluensulfone: Drinking 

Water Exposure Assessment for Proposed New Uses on Turfgrass" (J. Lin, 0424167, 19 

February 2015). The memorandum notes that the estimated drinking water concentrations 

(EOWCs) based on the use on turf are less than those derived from the use on cucurbit 

vegetables and fruiting vegetables. As the use patterns for the new crops are essentially identical 

to that for cucurbit and fruiting vegetables, HED has used the cucurbit/fruiting vegetable based 

EDWCs provided by EFEO (J. Lin, 0411774. I August 2013 and J. Lin, 0417634, 30 January 

2013). The drinking water residues used in the dietary risk assessment remain unchanged and 

can be found in the previous dietary risk assessment (0418204; M. Doherty : 10 June 2014). The 

estimated drinking water concentrations (EOWCs; Table 3) were incorporated directly into this 

dietary assessment via the food categories "water, direct, all sources" and ·'water, indirect, all 

sources." 

As previously noted, the residues of concern in drinking water are fluensulfone, deschlorofluensulfone, and MeS. Oeschloro-fluensulfone was only observed in environmental fate studies 

applicable to surface water residues and was not included in groundwater. The surface water 

estimates were obtained using a total-residue approach with Pesticide Root Zone Model and 

Exposure Analysis Model System (PRZM-EXAMS). The groundwater (EOWCs) were obtained 

using the Pesticide Root Zone Model-Ground Water (PRZM-GW) in a combined approach 

whereby residue estimates for :fluensulfone and MeS were obtained from separate analyses and 

then added together, resulting in conservative estimates of the combined residues. The drinking 

water models and their descriptions are available at the EPA internet site: Models for Pesticide 

Risk Assessment. 

Table 3. Fluensulfone Estimated Drinking Water Concentrations for Dietary Risk Assessment 

ID411774+D417634) 

Residue Source (Tier: Model) Use Rate, lb a.i./A/yr Acute EDWC, μg/L Chronic EDWC, μg/L 

Surface Water (Tier II: PRZM-EXAMS 3.57 11.8 0.173 

Groundwater (Tier I: PRZM-GW) 3.57 77.6 52.S 

The maximum values for acute and chronic EDWCs are from the groundwater modeling and 

were used in the dietary exposure assessment. 

Page 8of19 
Fluensulfone Dierary Exposure and Risk Assessment DP Number: 0432134 

V. DEEM-FCID Program and Consumption Information 

Fluensulfone acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 conswnption data from USOA's 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods .. as consumed" (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat fl our - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA conswnption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old. 

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup. 

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or '·matched" in multiple random pairings with residue va lues 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment. 

VI. Toxicological Information 

For fluensulfone, HED has selected the most sensitive and protective endpoints from the 

database to establish points of departure (PODs) for the risk assessment. The POD for acute 

dietary exposure was chosen from the 2-generation reproductive toxicity study in rats based on 

an increase in pup loss observed at 122.01169. l mg/kg/day (M/F) with a NOAEL of 16.2/23.0 

mg/kg/day (M/F). The POD for chronic dietary exposure was chosen from the chronic study in 

rats, based on a NOAEL of 9.6 mg/kg/day with decreased body weight in males. hematology and 

clinical chemistry changes, histopathological effects in the lung and esophagus at the LOAEL of 

Page 9of19 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: D432 I 34 

57.7 mg/kg/day. For both acute and chronic scenarios, the inter- and intra-species uncertainty 

factors are lOX each and the FQPA Safety Factor has been reduced to IX, resulting in an aPAD 

of0. 16 mg/kg/day and a cPAD of0.10 mg/kg/day. Fluensulfone has been classified as having 

suggestive evidence of carcinogenicity, with a finding that the RID is protective of cancer 

effects. 

Table 4. Summary of Toxicological Doses and Endpoints for use in Fluensulfone Dietary Human Health 

Risk Assessments. 

Exposure/ Scenario Point of Uncertainty/ RID. PAD, Study and Toxicological Effects 

Departure FQPA Safety Level of 

Factors Concern for Risk 

Assessment 

Acute Dietary (All Offspring UF"= I Ox Acute RID = 2-generation reproduction - rat 

Populations, NOAEL= 16.2 UFH= IOx 0.16 mg/kg/day Offspring LOAEL = 122.0 mg/kg/day 

including In fants and mg/kg/day FQPA SF= Ix based on an increase in pup loss 

Children and aPAD = 0.16 between PND I and 4 in the Fl and F2 

Females 13-49 years mg/kg/day offspring with the majority of deaths 

of age) occurring on day 2. 

Chronic Dietary (All NOAEL = 9.6 UFA= IOx Chronic RID = 2-year toxicity/carcinogenicity - rat 

Populations) mg/kg/day UF11=10x 0. 10 LOAEL = 57.7 mg/kg/day based on 

FQPA SF= Ix mg/kg/day decreased body weight in males, 

hematology and clinical chemistry 

cPAD =0. 10 changes, histopathological effects in 

mg/kg/day the lung and esophagus. 

Cancer (oral, dermal, Classification: Suggestive evidence of carcinogenicity in humans based on benign lung 

inhalation) tumors in female rats. The RID is protective of potential cancer effects. 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA= extrapolation from animal to human (interspecies). UF11 = potential variation in sensitivity 

among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population 

adjusted dose (a= acute, c = chronic). RID = reference dose. 

For BSA and TSA, oral acute lethality studies were showed these metabolites to be of low 

toxicity (Toxicity Category III). HED notes that all animals treated with BSA or TSA survived 

the entire study period and that the toxicity category for those metabolites is based on the dosing 

level rather than on actual LDso estimates. In 28-day oral toxicity studies with BSA and TSA, no 

treatment-related effects were observed at any dose (limit-dose = 1000 mg/kg/day). 

VII. Results/Discussion 

As previously stated, for acute and chronic assessments, HED is concerned when dietary risk 

estimates exceed 100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure of 

the U.S. population and various population subgroups. The risk estimates for the total U.S. 

population and all population subgroups are below HED's level of concern for both acute and 

chronic exposure durations (see Table 5). 

Page 10of19 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: 0432134 

Table 5. Summary of Acute and Chronic Dietary Exposure (Food and Drinking Water) and Risk Estimates 

fo r F luensulfone. 

Acute Dietary Chronic Dietary (95'b Percentile) Population Subgroup Dietary Exposure Dietary Exposure 

{me/k2/day) %aPAD* (me/kg/day) % cPAD* 

General U.S. Population 0.004809 3.0 0.001335 1.3 

All Infants (<I year old) 0.0 14794 9.3 0.00392 1 3.9 

Children 1-2 years old 0.008369 5.2 0.002283 2.3 

Children 3-5 years old 0.0065 13 4.1 0.00 18 11 1.8 

Children 6-12 years old 0.004649 2.9 0.001234 1.2 

Youth 13-19 years old 0.003774 2.4 0.000943 0.9 

Adults 20-49 years old 0.004564 2.9 0.001279 1.3 

Adults 50-99 years old 0.004 165 2.6 0.00 1297 1.3 

Females 13-49 years old 0.004601 2.9 0.001276 1.3 

Bold entries are maximum exposure and risk estimates. 

VIII. Char acterization oflnputs/Outputs 

The results in Table 5 reflect an unrefined, screening-level assessment and likely overestimate 

actual dietary exposure to fluensulfone. Various refinements could be made to the assessments. 

However. as there are no risk estimates of concern, no refinements were incorporated. 

IX. Conclusions 

Based on the unrefined nature of the acute and chronic dietary exposure assessments, HED is 

confident that the estimates do not underestimate risk to the general U.S. population or any 

population subgroup. There are no dietary exposure or risk considerations that would preclude 

granting the requested registrations and associated tolerances for fluensulfone. 

X. List of Attachments 

1. Inputs used in the acute dietary exposure assessment for fluensulfone. 

2. Inputs used in the chronic dietary exposure assessment for fluensulfone. 

3. Summary of acute dietary exposure and risk estimates for fluensulfone. 

4. Summary of chronic dietary exposure and risk estimates for fl uensulfone. 

Page 11 of 19 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: D432 I 34 

Attachment l: Inputs used in the acute dietary exposure assessment for fluensulfone. 

Filename : C: \Users\jcowins\Desktop\DEEM Files\Fluensulfone\Acute Fluensulfone-new . R08 

Chemical : Fluensulfone 

RfD(Chronic) : . 1 mg/kg bw/day NOEL(Chronic) : 0 mg/kg bw/day 

RfD(Acute) : . 16 mg/kg bw/day NOEL(Acute) : 0 mg/kg bw/day 

Date created/last modified : 04 - 26-2016/15 : 22 : 09 Program ver. 3 . 16, 03-08-d 

EPA Crop 

Code Grp Commodity Name 

Def Res 

(ppm) 

0101050000 lAB 

0101050001 !AB 

0101067000 lAB 

0101078000 lAB 

0101078001 lAB 

0101079000 lAB 

0101084000 !AB 

0101100000 !AB 

0101168000 lAB 

0101190000 lAB 

0101250000 lAB 

0101251000 lAB 

0101251001 lAB 

0101314000 lAB 

0101316000 lAB 

0101327000 lAB 

0101331000 lAB 

0101388000 lAB 

0103015000 lCD 

0103015001 lCD 

0103017000 lCD 

0103082000 lCD 

0103082001 !CD 

0103139000 lCD 

0103166000 lCD 

0103166001 lCD 

0103167000 lCD 

0103296000 lC 

0103297000 lC 

0103297001 lC 

0103298000 lC 

0103298001 lC 

0103299000 lC 

0103299001 lC 

0103300000 lC 

0103300001 lC 

0103366000 lCD 

0103366001 lCD 

0103371000 lCD 

0103387000 lCD 

0103406000 lCD 

0103407000 lCD 

0200051000 2 

0200101000 2 

0200140000 2 

0200315000 2 

0200317000 2 

0200332000 2 

0401005000 4A 

0401018000 4A 

0401104000 4A 

0401133000 4A 

0401134000 4A 

0401138000 4A 

0401150000 4A 

Beet, garden, roots 

Beet , garden, roots-babyfood 

Burdock 

Carrot 

Carrot-baby food 

Carrot , juice 

Celeriac 

Chicory, roots 

Ginseng , dried 

Horseradish 

Parsley, turnip rooted 

Parsnip 

Parsnip-babyfood 

Radish , roots 

Radish , Oriental , roots 

Rutabaga 

Salsify, roots 

Turnip, roots 

Arrowroot , flour 

Arrowroot , flour- babyfood 

Artichoke , Jerusalem 

Cassava 

Cassava-baby food 

Dasheen, corm 

Ginger 

Ginger-baby food 

Ginger, dried 

Potato, chips 

Potato, dry (granules/ flakes) 

Potato , dry (granules/ flakes)-b 

Potato, flour 

Potato , flour- babyfood 

Potato, tuber, w/peel 

Potato, tuber, w/peel-babyfood 

Potato, tuber, w/o peel 

Potato, tuber, w/o peel-babyfood 

Sweet potato 

Sweet potato-babyfood 

Tanier, corm 

Turmeric 

Yam, true 

Yam bean 

Beet , garden, tops 

Chicory, tops 

Dasheen, leaves 

Radish , tops 

Radish , Oriental , tops 

Salsify, tops 

Amaranth , leafy 

Arugula 

Chrysanthemum, garland 

Cress, garden 

Cress, upland 

Dandelion, leaves 

Endive 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 900000 

0 . 900000 

0 . 900000 

0 . 010000 

0 . 900000 

0 . 900000 

0 . 900000 

0 . 900000 

0 . 900000 

0 . 900000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 900000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

Page 12of 19 

Adj . Factors 

Ul #2 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

Comment 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: 0432134 

0401204000 4A Lettuce, head 0 . 030000 1 . 000 1 . 000 

040120SOOO 4A Lettuce , leaf 0 . 100000 1 . 000 1 . 000 

040124SOOO 4A Parsley, leaves 0 . 010000 1 . 000 1 . 000 

0401313000 4A Radicchio 0 . 030000 1 . 000 1 . 000 

04013SSOOO 4A Spinach 0 . 010000 1 . 000 1 . 000 

04013SS001 4A Spinach-baby food 0 . 010000 1 . 000 1 . 000 

0402076000 4B Cardoon 1 . 000000 1 . 000 1 . 000 

04020BSOOO 4B Celery 1 . 000000 1 . 000 1 . 000 

04020SS001 4B Celery-baby food 1 . 000000 1 . 000 1 . 000 

04020B6000 4B Celery, juice 1 . 000000 1 . 000 1 . 000 

04020B7000 4B Celtuce 1 . 000000 1 . 000 1 . 000 

04021S2000 4B f'enne l, Florence 1 . 000000 1 . 000 1 . 000 

0402322000 4B Rhubarb 1 . 000000 1 . 000 1 . 000 

0402367000 4B Swiss chard 1 . 000000 1 . 000 1 . 000 

OS01061000 SA Broccoli 0 . 010000 1 . 000 1 . 000 

OS01061001 SA Broccoli-baby food 0 . 010000 1 . 000 1 . 000 

OS01062000 SA Broccoli , Chinese 0 . 010000 1 . 000 1 . 000 

OS01064000 SA Brussels sprouts 0 . 010000 1 . 000 1 . 000 

OS01069000 SA Cabbage 0 . 010000 1 . 000 1 . 000 

OS01071000 SA Cabbage , Chinese , napa 0 . 010000 1 . 000 1 . 000 

0501072000 SA Cabbage , Chinese , mustard 0 . 010000 1 . 000 1 . 000 

OS010S3000 SA Cauliflower 0 . 010000 1 . 000 1 . 000 

OS01196000 SA Kohlrabi 0 . 010000 1 . 000 1 . 000 

0502063000 SB Broccoli raab 0 . 010000 1 . 000 1 . 000 

0502070000 SB Cabbage , Chinese , bok choy 0 . 010000 1 . 000 1 . 000 

0502117000 SB Collards 0 . 010000 1 . 000 1 . 000 

0502194000 SB Kale 0 . 010000 1.000 1 . 000 

OS02229000 SB Mustard greens 0 . 010000 1 . 000 1 . 000 

050231SOOO SB Rape greens 0 . 010000 1 . 000 1 . 000 

05023B9000 SB Turnip, greens 0 . 010000 1.000 1 . 000 

OB01374000 SA Tomati llo 0 . 010000 1.000 1 . 000 

OB01375000 BA Tomato 0 . 010000 1 . 000 1 . 000 

OB0137S001 BA Tomato-baby food 0 . 010000 1 . 000 1 . 000 

OB01376000 SA Tomato , paste 0 . 010000 1 . 000 1 . 000 

0801376001 BA Tomato , paste-baby food 0 . 010000 1 . 000 1 . 000 

OB01377000 BA Tomato, puree 0 . 010000 1 . 000 1 . 000 

OB01377001 BA Tomato , puree-baby food 0 . 010000 1 . 000 1 . 000 

OB0137BOOO BA Tomato , dried 0 . 010000 1 . 000 1 . 000 

OB0137B001 BA Tomato , dried-babyfood 0 . 010000 1 . 000 1 . 000 

OB01379000 BA Tomato , juice 0 . 010000 1 . 000 1 . 000 

OB013BOOOO SA Tomato , Tree 0 . 010000 1 . 000 1 . 000 

OB0214BOOO BBC Eggplant 0 . 010000 1 . 000 1 . 000 

OB02234000 BBC Okra 0 . 010000 1 . 000 1 . 000 

OB02270000 BB Pepper, bell 0 . 010000 1 . 000 1 . 000 

OB02270001 BB Pepper, bell-babyfood 0 . 010000 1 . 000 1 . 000 

OB02271000 SB Pepper, bell, dried 0 . 010000 1 . 000 1 . 000 

OB02271001 SB Pepper, bell, dned-babyfood 0 . 010000 1 . 000 1 . 000 

OB02272000 SBC Pepper, nonbell 0 . 010000 1 . 000 1 . 000 

OB02272001 BBC Pepper, nonbell-babyfood 0 . 010000 1 . 000 1 . 000 

OB02273000 BBC Pepper, nonbell, d r ied 0 . 010000 1 . 000 1 . 000 

0901075000 9A Canta l oupe 0 . 010000 1 . 000 1 . 000 

09011B7000 9A Honeydew melon 0 . 010000 1 . 000 1 . 000 

0901399000 9A Watermelon 0 . 010000 1 . 000 1 . 000 

0901400000 9A Watermelon , juice 0 . 010000 1 . 000 1 . 000 

0902021000 9B Balsam pear 0 . 010000 1 . 000 1 . 000 

0902088000 9B Chayote , fruit 0 . 010000 1 . 000 1 . 000 

0902102000 9B Chinese waxgourd 0 . 010000 1 . 000 1 . 000 

0902135000 9B Cucumber 0 . 010000 1 . 000 1 . 000 

090230BOOO 98 Pumpkin 0 . 010000 1 . 000 1 . 000 

0902309000 9B Pumpkin , seed 0 . 010000 1 . 000 1 . 000 

0902356000 9B Squash, summer 0 . 010000 1 . 000 1 . 000 

0902356001 98 Squash, sullUller-babyfood 0 . 010000 1 . 000 1 . 000 

0902357000 9B Squash, winter 0 . 010000 1 . 000 1 . 000 

0902357001 98 Squash, winter-baby food 0 . 010000 1 . 000 1 . 000 

1307130000 13G Cranberry 0 . 010000 1 . 000 1 . 000 

1307130001 13G Cranberry- baby food 0 . 010000 1 . 000 1 . 000 

1307131000 13G Cranberry, dried 0 . 010000 1 . 000 1 . 000 

Page 13of1 9 
Fluensulfone 

1307132000 13G 

1307132001 13G 

1307359000 13G 

1307359001 13G 

1307 360000 l 3G 

1307360001 13G 

8601000000 86A 

8602000000 869 

Dietary Exposure and Risk Assessment 

Cranberry, juice 

Cranberry, juice-babyfood 

Strawberry 

Strawberry-babyfood 

Strawberry, juice 

Strawberry, juice-babyfood 

Water, direct , all sources 

Water, indirect, all sources 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 077600 

0 . 077600 

Page 14 of 19 

DP Number: D432 I 34 

1.100 

1 . 100 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: D432 I 34 

Attachment 2: Inputs used in the chronic dietary exposure assessment for fl uensulfone. 

Filename : C : \Users\jcowins\Desktop\DEEM Fi l es\Fluensulfone\Chronic Fluensulfone- new . R08 

Chemical : Fluensulfone 

RfD(Chronic) : . 1 mg/kg bw/day NOEL(Ch ron ic) : 0 mg/kg bw/day 

RfD(Acute) : . 16 mg/kg bw/day NOEL(Acute ) : 0 mg/kg bw/day 

Date created/l ast modified : 04 - 26- 2016/15 : 25 : 41 Program ver. 3 . 16, 03-08 -d 

EPA Crop 

Code Grp Commodity Name 

Def Res 

(ppm) 

0101050000 lAB 

0101050001 lAB 

0101067000 lAB 

0101078000 lAB 

0101078001 !AB 

0101079000 l AB 

0101084000 lAB 

0101100000 lAB 

0101168000 lAB 

0101190000 !AB 

0101250000 lAB 

0101251000 lAB 

0101251001 lAB 

0101314000 lAB 

0101316000 lAB 

0101327000 lAB 

0101331000 lAB 

0101388000 lAB 

0103015000 lCD 

0103015001 lCD 

0103017000 lCD 

0103082000 lCD 

0103082001 lCD 

0103139000 lCD 

0103166000 lCD 

0103166001 lCD 

0103167000 lCD 

0103296000 lC 

0103297000 lC 

0103297001 lC 

0103298000 lC 

0103298001 lC 

0103299000 lC 

0103299001 lC 

0103300000 lC 

0103300001 lC 

0103366000 lCD 

0103366001 lCD 

0103371000 lCD 

0103387000 lCD 

0103406000 lCD 

0103407000 lCD 

0200051000 2 

0200101000 2 

0200 140000 2 

0200315000 2 

0200317000 2 

0200332000 2 

0401005000 4A 

0401018000 4A 

0401104000 4A 

0401133000 4A 

0401134000 4A 

0401138000 4A 

0401150000 4A 

Beet , garden, roots 

Beet , garden, roots-babyfood 

Burdock 

Carrot 

Carrot-babyfood 

Carrot , juice 

Celeriac 

Chicory, roots 

Ginseng , dried 

Horseradish 

Parsley, turnip rooted 

Parsnip 

Parsnip-baby food 

Radish , roots 

Radish , Oriental , roots 

Rutabaga 

Salsify, roots 

Turnip, roots 

Arrowroot , flour 

Arrowroot , flour-babyfood 

Artichoke , Jerusalem 

Cassava 

Cassava-baby food 

Dasheen, corm 

Ginger 

Ginger-baby food 

Ginger, dried 

Potato, chips 

Potato, dry (granules/ f lakes) 

Potato, dry (granules/ f lakes)-b 

Potato, flour 

Potato, flour- babyfood 

Potato, tuber, w/peel 

Potato, tuber, w/peel-babyfood 

Potato, tuber, w/o peel 

Potato, tuber, w/o peel- babyfood 

Sweet potato 

Sweet potato-babyfood 

Tanier, corm 

Turmeric 

Yam, true 

Yam bean 

Beet, garden , tops 

Chicory, tops 

Dasheen , leaves 

Radish , tops 

Radish , Oriental, tops 

Salsify, tops 

Amaranth, leafy 

Arugula 

Chrysanthemum, garland 

Cress, garden 

Cress, upland 

Dandelion, leaves 

Endive 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 900000 

0 . 900000 

0 . 900000 

0 . 010000 

0 . 900000 

0 . 900000 

0 . 900000 

0 . 900000 

0 . 900000 

0 . 900000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 900000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 0 10000 

0 . 0 10000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 0 10000 

0 . 0 10000 

0 . 0 10000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

Page 15of 19 

Ad j . Factors Comment 

U H2 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1. 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: D432 I 34 

0401204000 4A Lettuce , head 0 . 030000 1 . 000 1 . 000 

0401205000 4A Lettuce, leaf 0 . 100000 1 . 000 1 . 000 

0401248000 4A Parsley, leaves 0 . 010000 1 . 000 1 . 000 

0401313000 4A Radicchio 0 . 030000 1 . 000 1 . 000 

04013SS000 4A Spinach 0 . 010000 1 . 000 1 . 000 

04013SS001 4A Spinach-baby food 0 . 010000 1 . 000 1 . 000 

0402076000 48 Cardoon 1 . 000000 1 . 000 1 . 000 

0402085000 48 Celery 1 . 000000 1 . 000 1 . 000 

040208S001 48 Celery-babyfood 1 . 000000 1 . 000 1 . 000 

0402086000 48 Celery, juice 1 . 000000 1 . 000 1 . 000 

0402087000 48 Celtuce 1 . 000000 1 . 000 1 . 000 

04021S2000 4B Fennel, Fl orence 1 . 000000 1 . 000 1 . 000 

0402322000 48 Rhubarb 1 . 000000 1 . 000 1 . 000 

0402367000 4B Swiss chard 1 . 000000 1 . 000 1 . 000 

OS01061000 SA Broccoli 0 . 010000 1 . 000 1 . 000 

OS01061001 SA Broccoli- babyfood 0 . 010000 1 . 000 1 . 000 

0501062000 SA Broccoli , Chinese 0 . 010000 1 . 000 1 . 000 

0501064000 SA Brussels sprouts 0 . 010000 1 . 000 1 . 000 

0501069000 SA Cabbage 0 . 010000 1 . 000 1 . 000 

0501071000 SA Cabbage , Chinese , napa 0 . 010000 1 . 000 1 . 000 

OS01072000 SA Cabbage , Chinese , mustard 0 . 010000 1 . 000 1 . 000 

0501083000 SA Caul if lower 0 . 010000 1 . 000 1 . 000 

OS01196000 SA Kohlrabi 0 . 010000 1 . 000 1 . 000 

OS02063000 SB Broccoli raab 0 . 010000 1 . 000 1 . 000 

0502070000 SB Cabbage , Chinese , bok choy 0 . 010000 1 . 000 1 . 000 

0502117000 SB Collards 0 . 010000 1 . 000 1 . 000 

0502194000 58 Kale 0 . 010000 1 . 000 1 . 000 

0502229000 5B Mustard greens 0 . 010000 1 . 000 1.000 

0502318000 SB Rape greens 0 . 010000 1 . 000 1 . 000 

0502389000 SB Turnip, greens 0 . 010000 1 . 000 1 . 000 

0801374000 SA Tomatillo 0 . 010000 1 . 000 1 . 000 

080137SOOO BA Tomato 0 . 010000 1 . 000 1 . 000 

080137S001 BA Tomato- baby food 0 . 010000 1 . 000 1 . 000 

0801376000 BA Tomato , paste 0 . 010000 1 . 000 1 . 000 

0801376001 BA Tomato , paste- baby food 0 . 010000 1 . 000 1 . 000 

0801377000 SA Tomato, puree 0 . 010000 1 . 000 1 . 000 

0801377001 SA Tomato , puree-baby food 0 . 010000 1 . 000 1 . 000 

0801378000 SA Tomato , dried 0 . 010000 1.000 1 . 000 

0801378001 8A Tomato, dried-babyfood 0 . 010000 1 . 000 1 . 000 

0801379000 8A Tomato , juice 0 . 010000 1 . 000 1 . 000 

0801380000 BA Tomato, Tree 0 . 010000 1 . 000 1.000 

0802148000 8BC Eggplant 0 . 010000 1 . 000 1 . 000 

0802234000 BBC Okra 0 . 010000 1 . 000 1 . 000 

0802270000 8B Pepper, bell 0 . 010000 1 . 000 1 . 000 

0802270001 8B Pepper, bell-babyfood 0 . 010000 1 . 000 1 . 000 

0802271000 8B Pepper, bell, dried 0 . 010000 1 . 000 1 . 000 

0802271001 88 Pepper, bell, dried-baby food 0 . 010000 1 . 000 1 . 000 

0802272000 SBC Pepper, nonbell 0 . 010000 1 . 000 1 . 000 

0802272001 8BC Pepper, nonbell-babyfood 0 . 010000 1 . 000 1 . 000 

0802273000 SBC Pepper, nonbell , dried 0 . 010000 1 . 000 1 . 000 

0901075000 9A Cantaloupe 0 . 010000 1 . 000 1 . 000 

0901187000 9A Honeydew melon 0 . 010000 1 . 000 1 . 000 

0901399000 9A Watermelon 0 . 010000 1 . 000 1 . 000 

0901400000 9A Watermelon , juice 0 . 010000 1 . 000 1 . 000 

0902021000 98 Balsam pear 0 . 010000 1 . 000 1 . 000 

0902088000 98 Chayote , fruit 0 . 010000 1 . 000 1 . 000 

0902102000 98 Chinese waxgourd 0 . 010000 1.000 1 . 000 

090213SOOO 98 Cucumber 0 . 010000 1 . 000 1 . 000 

0902308000 98 Pumpkin 0 . 010000 1 . 000 1 . 000 

0902309000 98 Pumpkin, seed 0 . 010000 1 . 000 1 . 000 

09023S6000 9B Squash, surruner 0 . 010000 1 . 000 1 . 000 

0902356001 9B Squash, surruner-babyf ood 0 . 010000 1 . 000 1. 000 

0902357000 98 Squash, winter 0 . 010000 1 . 000 1.000 

0902357001 98 Squash, winter-babyfood 0 . 010000 1 . 000 1 . 000 

1307130000 13G Cranberry 0 . 010000 1 . 000 1 . 000 

1307130001 13G Cranberry-babyfood 0 . 010000 1 . 000 1.000 

1307131000 13G Cranberry, dried 0 . 010000 1 . 000 1 . 000 

Page 16of19 
Fluensulfonc 

1307132000 13G 

1307132001 13G 

1307359000 13G 

1307359001 13G 

1307360000 13G 

1307360001 13G 

8601000000 86A 

8602000000 868 

Dietary Exposure and Risk Assessment 

Cranberry, juice 

Cranberry, j uice-babyfood 

Strawberry 

Strawberry-baby food 

Strawberry, juice 

Strawberry, juice-babyfood 

Water, direct, all sources 

Water, indirect , all sources 

Page 17of19 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 010000 

0 . 052500 

0 . 052500 

DP Number: D432 I 34 

1 . 100 

1 . 100 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 
Fluensu lfone Dietary Exposure and Risk Assessment DP Number: D432134 

Attaclunent 3: Summary of acute dietary exposure and risk estimates for fluensulfone. 

OPP Health Effects Division 

DEEM-fCI D ACUTE Ana l ys is for fLUENSULfONE 

Residue file : Acute fluensulfone-new. R08 

Analysis Date : 03- 28 - 2016/11 : 29 : 58 

RAC/ff intake summed over 24 hours 

Run Comment : " " 

Ver . 3 . 18 , 03-08-d 

NHANES 2003- 2008 2-Day 

Adj ustment factor #2 NOT used . 

Residue f ile dated : 04-26-2016/15 : 22 : 09 

=============================================================================== 

Summary c a lculations--per capita : 

95th Percentile 99th Percentile 99 . 9th Pe r centile 

Exposure ., aRf D Exposure aRfD Exposure !l aRfD 

---------- -------- ---------- -------- ---------- -------- Total us Population : 

0 . 004809 3 . 01 0 . 008011 5 . 01 0 . 014867 9 . 29 

All Infants: 

0 . 014794 9. 25 0 . 019945 12 . 47 0 . 026488 16 . 55 

Children 1-2 : 

0 . 008369 5 . 23 0 . 013840 8 . 65 0 . 026403 16 . 50 

Children 3-5 : 

0 . 006513 4 . 07 0 . 009656 6. 03 0 . 014524 9 . 08 

Children 6-12 : 

0 . 004649 2 . 91 0 . 007463 4 . 66 0 . 011266 7 . 04 

Youth 13- 19 : 

0 . 003774 2 . 36 0 . 006061 3. 79 0 . 009235 5 . 77 

Adults 20-49 : 

0 . 004564 2 .85 0 . 006547 4 . 09 0 . 009139 5 . 71 

Adults 50-99 : 

0 . 004165 2 . 60 0 . 006055 3 . 78 0 . 00902 4 5 . 64 

female 13- 49 : 

0 . 004601 2 .88 0 . 006488 4 . 06 0 . 008989 5 . 62 

Page 18of19 
Fluensulfone Dietary Exposure and Risk Assessment DP Number: 0432134 

Attachment 4: Summary of chronic dietary exposure and risk estimates for fluensulfone. 

OPP Health Effects Division Ver . 3 . 16, 03- 08- d 

DEEM-FCID Chronic analysis for FLUENSULFONE NHANES 2003- 2008 2- day 

Residue file name : C: \Users\jcowins\Desktop\DEEM Files\Fluensulfone\Chronic Fluensulfonenew . R08 

AdJUStment factor H2 NOT used . 

Analysis Date 03 - 28 - 2016/13 : 38 : 52 Residue file dated : 04-26- 2016/15 : 25 : 41 

Reference dose CRfD, Chronic) = . 1 mg/kg bw/day 

=============================================================================== 

Population 

Subgroup 

Total US Population 

Hispanic 

Non-Hisp-White 

Non-Hisp-Black 

Non-Hisp-Other 

Nursing Infants 

Non-Nursing Infants 

Female 13+ PREG 

Children 1-6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1-2 

Children 3-5 

Children 6-12 

Youth 13-19 

Adults 20-49 

Adults 50-99 

Female 13-49 

Total exposure by population subgroup 

Total Exposure 

mg/kg 

body wt/day 

0 . 001335 

0 . 001301 

0 . 001370 

0 . 001063 

0 . 001593 

0 . 001845 

0 . 004848 

0 . 001190 

0 . 001946 

0 . 001167 

0 . 000892 

0 . 000993 

0 . 001204 

0 . 001365 

0 . 001282 

0 . 003921 

0 . 001278 

0 . 002283 

0 . 001811 

0 . 001234 

0 . 000943 

0 . 001279 

0 . 001297 

0 . 001276 

Page 19 of 19 

Percent of 

Rfd 

1. 3% 

1. 3% 

1. 4% 

1.1% 

1. 6% 

1.8% 

4.8% 

1. 2% 

1. 9% 

1.2% 

0 . 9% 

1.0% 

1.2% 

1. 4% 

1. 3% 

3 . 9% 

1. 3% 

2 . 3% 

l. 8% 

1.2% 

0 . 9% 

1. 3% 

1. 3% 

1. 3%