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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 1 (MALES - COMBINED PHASES)

SUMMARY OF BODY WEIGHTS [G]DATA PRESENTED AS MEAN ± SE

BW v1.00 07/15/2009

0

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3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 2 (FEMALES - COMBINED PHASES)

SUMMARY OF BODY WEIGHTS [G]

DATA PRESENTED AS ± SE

BW v1.00 07/15/2009

0

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BODY WEIGHT (GRAMS)

STUDY WEEK

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 3 (MALES - TOTAL COUNTS IN SESSION - PHASE II)

SUMMARY OF TOTAL MOTOR ACTIVITY COUNTS

DATA PRESENTED AS MEAN ± SE

0

500

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2500200015001000

PRETEST WEEK 3

TS IN SESSION MEAN TOTAL COUN

STUDY WEEK

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 4 (MALES - TOTAL COUNTS IN SESSION - PHASE II)

SUMMARY OF AMBULATORY MOTOR ACTIVITY COUNTS

DATA PRESENTED AS MEAN ± SE

0

800

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1200

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PRETEST WEEK 3

MEAN AMBULATORY COUNTS IN SESSION

STUDY WEEK

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 5 (FEMALES - TOTAL COUNTS IN SESSION - PHASE II)

SUMMARY OF TOTAL MOTOR ACTIVITY COUNTS

DATA PRESENTED AS MEAN ± SE

0

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300020001000

PRETEST WEEK 3

TS IN SESSION MEAN TOTAL COUN

STUDY WEEK

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 6 (FEMALES - TOTAL COUNTS IN SESSION - PHASE II)

SUMMARY OF AMBULATORY MOTOR ACTIVITY COUNTS

DATA PRESENTED AS MEAN ± SE

0

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1600140012001000

PRETEST WEEK 3

MEAN AMBULATORY COUNTS IN SESSION

STUDY WEEK

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

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 PROJECT NO.: 534015 FIGURE 7 (MALES - PRETEST - PHASE II)

SUMMARY OF TOTAL MOTOR ACTIVITY COUNTS

DATA PRESENTED AS MEAN ± SE

1600140012001000

UNTSO

0

800600400200

0 TO 10 11 TO 20 21 TO 30 31 TO 40 41 TO 50 51 TO 60

O MEAN TOTAL C

TIME (MINUTES)

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 8 (MALES - PRETEST - PHASE II)

SUMMARY OF AMBULATORY MOTOR ACTIVITY COUNTS

DATA PRESENTED AS MEAN ± SE

0

600500400

300200100

0 TO 10 11 TO 20 21 TO 30 31 TO 40 41 TO 50 51 TO 60

MEAN AMBULATORY COUNTS

TIME (MINUTES)

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 9 (FEMALES - PRETEST - PHASE II)

SUMMARY OF TOTAL MOTOR ACTIVITY COUNTS

DATA PRESENTED AS MEAN ± SE

0

800600400200

1800160014001200

1000

0 TO 10 11 TO 20 21 TO 30 31 TO 40 41 TO 50 51 TO 60

MEAN TOTAL COUNTS

TIME (MINUTES)

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 10 (FEMALES - PRETEST - PHASE II)

SUMMARY OF AMBULATORY MOTOR ACTIVITY COUNTS

DATA PRESENTED AS MEAN ± SE

0

600500400

300200100

0 TO 10 11 TO 20 21 TO 30 31 TO 40 41 TO 50 51 TO 60

MEAN AMBULATORY COUNTS

TIME (MINUTES)

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 11 (MALES - WEEK 3 - PHASE II)

SUMMARY OF TOTAL MOTOR ACTIVITY COUNTS

DATA PRESENTED AS MEAN ± SE

0

800600400200

1600140012001000

0 TO 10 11 TO 20 21 TO 30 31 TO 40 41 TO 50 51 TO 60

MEAN TOTAL COUNTS

TIME (MINUTES)

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 12 (MALES - WEEK 3 - PHASE II)

SUMMARY OF AMBULATORY MOTOR ACTIVITY COUNTS

DATA PRESENTED AS MEAN ± SE

0

50

450400350300

250200150100

0 TO 10 11 TO 20 21 TO 30 31 TO 40 41 TO 50 51 TO 60

MEAN AMBULATORY COUNTS

TIME (MINUTES)

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 13 (FEMALES - WEEK 3 - PHASE II)

SUMMARY OF TOTAL MOTOR ACTIVITY COUNTS

DATA PRESENTED AS MEAN ± SE

0

800600400200

1800160014001200

1000

0 TO 10 11 TO 20 21 TO 30 31 TO 40 41 TO 50 51 TO 60

MEAN TOTAL COUNTS

TIME (MINUTES)

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 PROJECT NO.: 534015 FIGURE 14 (FEMALES - WEEK 3 - PHASE II)

SUMMARY OF AMBULATORY MOTOR ACTIVITY COUNTS

DATA PRESENTED AS MEAN ± SE

0

50

500450400350300250200

150100

0 TO 10 11 TO 20 21 TO 30 31 TO 40 41 TO 50 51 TO 60

MEAN AMBULATORY COUNTS

TIME (MINUTES)

0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM

3DJHRI

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 TABLE 1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS  ----- M A L E -----  ----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 02-18-09 TO 03-27-09  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NORMAL  -NO SIGNIFICANT CLINICAL OBSERVATIONS 95/15 98/15 83/15 67/15 88/15 DISPOSITION  -FOUND DEAD 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0  -SCHEDULED EUTHANASIA 15/15 15/15 15/15 14/14 15/15 BODY/INTEGUMENT  -HAIR LOSS RIGHT FORELIMB 4/ 1 1/ 1 12/ 4 18/ 6 8/ 3  -HAIR LOSS LEFT FORELIMB 1/ 1 1/ 1 11/ 3 20/ 6 8/ 3  -HAIR LOSS DORSAL HEAD 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1  -HAIR LOSS VENTRAL ABDOMINAL AREA 0/ 0 0/ 0 6/ 2 6/ 3 0/ 0  -HAIR LOSS VENTRAL THORACIC AREA 0/ 0 0/ 0 5/ 2 0/ 0 0/ 0  -HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 0/ 0 0/ 0 3/ 1 1/ 1 0/ 0  -HAIR LOSS RIGHT HINDLIMB 0/ 0 0/ 0 0/ 0 3/ 1 0/ 0  -HAIR LOSS LEFT HINDLIMB 0/ 0 0/ 0 1/ 1 1/ 1 0/ 0  -HAIR LOSS RIGHT INGUINAL AREA 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0  -HAIR LOSS LEFT INGUINAL AREA 0/ 0 0/ 0 1/ 1 1/ 1 0/ 0  -HAIR LOSS UROGENITAL AREA 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0  EYES/EARS/NOSE  -DRIED RED MATERIAL AROUND RIGHT EYE 0/ 0 0/ 0 2/ 1 2/ 1 0/ 0  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM 

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 TABLE 1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS  ----- M A L E -----  ----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 02-18-09 TO 03-27-09  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- EYES/EARS/NOSE  -DRIED RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 5/ 5 2/ 2  -DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0  ORAL/DENTAL  -UPPER INCISORS MALALIGNED 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM 

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3  SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS  ----- F E M A L E -----  ----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 02-18-09 TO 03-27-09  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NORMAL  -NO SIGNIFICANT CLINICAL OBSERVATIONS 92/15 88/15 83/15 76/15 77/15 DISPOSITION  -EUTHANIZED IN EXTREMIS 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1  -SCHEDULED EUTHANASIA 15/15 15/15 15/15 15/15 14/14 BODY/INTEGUMENT  -HAIR LOSS RIGHT FORELIMB 6/ 3 9/ 2 14/ 4 18/ 5 5/ 4  -HAIR LOSS LEFT FORELIMB 7/ 3 9/ 2 13/ 4 18/ 6 3/ 2  -HAIR LOSS DORSAL HEAD 0/ 0 2/ 1 0/ 0 0/ 0 4/ 1  -HAIR LOSS VENTRAL ABDOMINAL AREA 0/ 0 0/ 0 4/ 2 14/ 5 14/ 4  -HAIR LOSS VENTRAL THORACIC AREA 0/ 0 0/ 0 0/ 0 7/ 3 8/ 3  -HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 0/ 0 0/ 0 0/ 0 6/ 3 7/ 3  -HAIR LOSS LEFT LATERAL ABDOMINAL AREA 0/ 0 0/ 0 0/ 0 6/ 3 8/ 3  -HAIR LOSS RIGHT HINDLIMB 0/ 0 0/ 0 0/ 0 9/ 3 9/ 3  -HAIR LOSS LEFT HINDLIMB 0/ 0 0/ 0 2/ 1 10/ 4 9/ 3  -HAIR LOSS RIGHT INGUINAL AREA 0/ 0 0/ 0 0/ 0 4/ 2 4/ 3  -HAIR LOSS LEFT INGUINAL AREA 0/ 0 0/ 0 0/ 0 4/ 2 4/ 2  -HAIR LOSS RUMP 0/ 0 0/ 0 0/ 0 3/ 1 0/ 0  -HAIR LOSS RIGHT AXILLARY AREA 0/ 0 0/ 0 0/ 0 2/ 1 0/ 0  -HAIR LOSS LEFT AXILLARY AREA 0/ 0 0/ 0 0/ 0 2/ 1 0/ 0  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM 

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4  SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS  ----- F E M A L E -----  ----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 02-18-09 TO 03-27-09  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- BODY/INTEGUMENT  -HAIR LOSS UROGENITAL AREA 0/ 0 0/ 0 0/ 0 2/ 1 0/ 0  EYES/EARS/NOSE  -DRIED RED MATERIAL AROUND RIGHT EYE 0/ 0 0/ 0 0/ 0 0/ 0 1/ 1  -DRIED RED MATERIAL AROUND NOSE 1/ 1 0/ 0 0/ 0 0/ 0 1/ 1  -DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  PCSUv4.07 05/18/2009 R:05/18/2009

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 TABLE 2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS  ----- M A L E -----  ----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 02-25-09 TO 03-26-09  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NORMAL  -NO SIGNIFICANT CLINICAL OBSERVATIONS 400/15 398/15 400/15 396/15 399/15 EYES/EARS/NOSE  -DRIED RED MATERIAL AROUND NOSE 0/ 0 0/ 0 0/ 0 1/ 1 1/ 1  ORAL/DENTAL  -DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 2/ 2 0/ 0  -WET CLEAR MATERIAL AROUND MOUTH 0/ 0 1/ 1 0/ 0 0/ 0 0/ 0  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM 

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 TABLE 2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS  ----- F E M A L E -----  ----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 02-25-09 TO 03-26-09  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NORMAL  -NO SIGNIFICANT CLINICAL OBSERVATIONS 398/15 400/15 394/15 398/15 396/15 EYES/EARS/NOSE  -DRIED RED MATERIAL AROUND RIGHT EYE 0/ 0 0/ 0 0/ 0 0/ 0 4/ 1  -DRIED RED MATERIAL AROUND NOSE 1/ 1 0/ 0 4/ 3 2/ 2 0/ 0  -DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 2/ 1 0/ 0 0/ 0  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  PCSUv4.07 05/11/2009 R:05/12/2009

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 TABLE 3 (MIDPOINT OF EXPOSURE - COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS  ----- M A L E -----  ----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 02-25-09 TO 03-26-09  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- BEHAVIOR/CNS  -INTERMITTENT TREMORS 0/ 0 0/ 0 0/ 0 12/ 4 37/11 -CONTINUOUS TREMORS 0/ 0 0/ 0 0/ 0 0/ 0 4/ 2  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM 

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 TABLE 3 (MIDPOINT OF EXPOSURE - COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS  ----- F E M A L E -----  ----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 02-25-09 TO 03-26-09  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- BEHAVIOR/CNS  -INTERMITTENT TREMORS 0/ 0 0/ 0 0/ 0 15/ 2 29/10 -CONTINUOUS TREMORS 0/ 0 0/ 0 0/ 0 0/ 0 7/ 2  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  PCSUv4.07 05/07/2009 R:05/12/2009

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 TABLE 4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS  ----- M A L E -----  ----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 02-25-09 TO 03-26-09  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NORMAL  -NO SIGNIFICANT CLINICAL OBSERVATIONS 305/15 306/15 289/15 270/15 261/15 BEHAVIOR/CNS  -INTERMITTENT TREMORS 0/ 0 0/ 0 0/ 0 1/ 1 0/ 0  BODY/INTEGUMENT  -LIMBS COOL 0/ 0 0/ 0 12/ 6 18/10 31/10 EYES/EARS/NOSE  -DRIED RED MATERIAL AROUND RIGHT EYE 0/ 0 0/ 0 0/ 0 3/ 1 1/ 1  -DRIED RED MATERIAL AROUND NOSE 3/ 2 2/ 2 5/ 4 12/ 5 15/ 8  -WET RED MATERIAL AROUND NOSE 2/ 1 0/ 0 4/ 4 3/ 2 0/ 0  ORAL/DENTAL  -DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 1/ 1 8/ 6  -DRIED CLEAR MATERIAL AROUND MOUTH 0/ 0 2/ 2 0/ 0 0/ 0 1/ 1  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM 

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 TABLE 4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS  ----- F E M A L E -----  ----------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 02-25-09 TO 03-26-09  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NORMAL  -NO SIGNIFICANT CLINICAL OBSERVATIONS 309/15 309/15 290/15 283/15 267/15 BEHAVIOR/CNS  -INTERMITTENT TREMORS 0/ 0 0/ 0 0/ 0 4/ 3 2/ 2  BODY/INTEGUMENT  -LIMBS COOL 0/ 0 0/ 0 2/ 2 15/ 8 22/ 8  EYES/EARS/NOSE  -DRIED RED MATERIAL AROUND RIGHT EYE 0/ 0 0/ 0 1/ 1 0/ 0 3/ 1  -DRIED RED MATERIAL AROUND NOSE 1/ 1 1/ 1 4/ 2 8/ 3 15/ 4  -WET RED MATERIAL AROUND NOSE 0/ 0 0/ 0 1/ 1 0/ 0 1/ 1  -DRIED RED MATERIAL AROUND LEFT EYE 0/ 0 0/ 0 2/ 1 0/ 0 0/ 0  ORAL/DENTAL  -DRIED RED MATERIAL AROUND MOUTH 0/ 0 0/ 0 0/ 0 3/ 2 7/ 2  -WET CLEAR MATERIAL AROUND MOUTH 0/ 0 0/ 0 1/ 1 0/ 0 0/ 0  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  PCSUv4.07 05/07/2009 R:05/12/2009

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 TABLE 5 (COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF BODY WEIGHTS [G]  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- WEEK -1  MEAN 231. 231. 231. 231. 232.  % DIFFERENCE 0.0 0.0 0.0 0.4  S.D. 36.8 33.3 32.6 34.8 33.4  S.E. 9.5 8.6 8.4 9.0 8.6  N 15 15 15 15 15  0  MEAN 284. 286. 284. 279. 283.  % DIFFERENCE 0.7 0.0 -1.8 -0.4  S.D. 26.5 23.4 19.6 25.1 20.8  S.E. 6.8 6.0 5.1 6.5 5.4  N 15 15 15 15 15  1  MEAN 314. 320. 312. 305. 303.  % DIFFERENCE 1.9 -0.6 -2.9 -3.5  S.D. 28.5 24.6 22.4 32.4 26.7  S.E. 7.4 6.4 5.8 8.4 6.9  N 15 15 15 15 15  2  MEAN 342. 354. 345. 336. 332.  % DIFFERENCE 3.5 0.9 -1.8 -2.9  S.D. 34.0 26.6 27.7 39.0 29.7  S.E. 8.8 6.9 7.1 10.1 7.7  N 15 15 15 15 15  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 5 (COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF BODY WEIGHTS [G]  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- WEEK 3  MEAN 370. 384. 377. 367. 361.  % DIFFERENCE 3.8 1.9 -0.8 -2.4  S.D. 37.5 28.3 30.8 40.5 29.7  S.E. 9.7 7.3 7.9 10.4 7.7  N 15 15 15 15 15  PRIOR TO EUTHANASIA -A  MEAN 385. 400. 394. 376. 377.  % DIFFERENCE 3.9 2.3 -2.3 -2.1  S.D. 39.5 26.1 33.7 52.0 26.8  S.E. 10.2 6.7 8.7 13.4 6.9  N 15 15 15 15 15  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group  A = A NON-FASTED WEIGHT WAS RECORDED PRIOR TO NECROPSY FOR ALL ANIMALS IN PHASE I (STUDY WEEK 3) AND PHASE II (STUDY WEEK 3 OR 4) 

3DJHRI

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 TABLE 5 (COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3  SUMMARY OF BODY WEIGHTS [G]  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- WEEK -1  MEAN 177. 177. 179. 177. 177.  % DIFFERENCE 0.0 1.1 0.0 0.0  S.D. 22.9 15.1 23.3 16.4 14.9  S.E. 5.9 3.9 6.0 4.2 3.8  N 15 15 15 15 15  0  MEAN 202. 199. 200. 200. 198.  % DIFFERENCE -1.5 -1.0 -1.0 -2.0  S.D. 22.3 12.3 20.8 12.3 12.8  S.E. 5.8 3.2 5.4 3.2 3.3  N 15 15 15 15 15  1  MEAN 223. 218. 220. 219. 219.  % DIFFERENCE -2.2 -1.3 -1.8 -1.8  S.D. 25.4 11.9 22.3 15.5 16.1  S.E. 6.6 3.1 5.8 4.0 4.1  N 15 15 15 15 15  2  MEAN 237. 235. 237. 237. 235.  % DIFFERENCE -0.8 0.0 0.0 -0.8  S.D. 28.4 14.9 22.6 17.2 17.8  S.E. 7.3 3.9 5.8 4.4 4.6  N 15 15 15 15 15  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 5 (COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4  SUMMARY OF BODY WEIGHTS [G]  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- WEEK 3  MEAN 252. 252. 253. 254. 248.  % DIFFERENCE 0.0 0.4 0.8 -1.6  S.D. 32.2 19.6 21.2 14.1 18.5  S.E. 8.3 5.1 5.5 3.6 4.8  N 15 15 15 15 15  PRIOR TO EUTHANASIA -A  MEAN 259. 259. 261. 263. 258.  % DIFFERENCE 0.0 0.8 1.5 -0.4  S.D. 29.6 21.2 18.1 16.9 21.0  S.E. 7.6 5.5 4.7 4.4 5.4  N 15 15 15 15 15  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group  A = A NON-FASTED WEIGHT WAS RECORDED PRIOR TO NECROPSY FOR ALL ANIMALS IN PHASE I (STUDY WEEK 3) AND PHASE II (STUDY WEEK 3 OR 4)  PBFSTv5.30 06/15/2009 R:06/18/2009

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 TABLE 6 (COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF BODY WEIGHT CHANGES [G]  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- WEEK -1 TO 0  MEAN 53. 55. 53. 48. 51.  S.D. 17.6 14.1 21.4 18.1 19.7  S.E. 4.5 3.6 5.5 4.7 5.1  N 15 15 15 15 15  0 TO 1  MEAN 29. 34. 28. 26. 21.*  S.D. 9.1 4.7 7.3 8.6 8.9  S.E. 2.4 1.2 1.9 2.2 2.3  N 15 15 15 15 15  1 TO 2  MEAN 28. 34. 33. 31. 29.  S.D. 8.7 4.8 9.2 8.7 4.6  S.E. 2.2 1.2 2.4 2.2 1.2  N 15 15 15 15 15  2 TO 3  MEAN 28. 30. 32. 31. 28.  S.D. 8.2 7.8 6.3 5.5 9.1  S.E. 2.1 2.0 1.6 1.4 2.4  N 15 15 15 15 15  3 TO PRIOR TO NECROPSY -A  MEAN 15. 17. 18. 9. 16.  S.D. 7.8 6.6 13.6 23.3 9.5  S.E. 2.0 1.7 3.5 6.0 2.5  N 15 15 15 15 15  ----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett’s test  A = A NON-FASTED WEIGHT WAS RECORDED PRIOR TO NECROPSY FOR ALL ANIMALS IN PHASE I (STUDY WEEK 3) AND PHASE II (STUDY WEEK 3 OR 4) 

3DJHRI

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 TABLE 6 (COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF BODY WEIGHT CHANGES [G]  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- WEEK -1 TO 0  MEAN 24. 21. 21. 23. 21.  S.D. 7.6 11.8 8.9 10.0 10.3  S.E. 2.0 3.1 2.3 2.6 2.7  N 15 15 15 15 15  0 TO 1  MEAN 22. 19. 19. 19. 22.  S.D. 6.1 5.2 5.5 6.9 7.2  S.E. 1.6 1.3 1.4 1.8 1.8  N 15 15 15 15 15  1 TO 2  MEAN 14. 17. 17. 18. 15.  S.D. 5.6 6.8 7.3 5.2 6.8  S.E. 1.4 1.7 1.9 1.3 1.8  N 15 15 15 15 15  2 TO 3  MEAN 15. 17. 16. 17. 14.  S.D. 8.7 10.2 7.5 8.1 5.1  S.E. 2.2 2.6 1.9 2.1 1.3  N 15 15 15 15 15  3 TO PRIOR TO NEROPSY -A  MEAN 7. 7. 8. 10. 10.  S.D. 6.8 5.1 9.3 6.3 8.0  S.E. 1.8 1.3 2.4 1.6 2.1  N 15 15 15 15 15  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group  A = A NON-FASTED WEIGHT WAS RECORDED PRIOR TO NECROPSY FOR ALL ANIMALS IN PHASE I (STUDY WEEK 3) AND PHASE II (STUDY WEEK 3 OR 4)  PBFSTv5.30 06/15/2009 R:06/18/2009

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 TABLE 7 (COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF CUMULATIVE BODY WEIGHT CHANGES [G]  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- WEEK 0 TO 1  MEAN 29. 34. 28. 26. 21.*  S.D. 9.1 4.7 7.3 8.6 8.9  S.E. 2.4 1.2 1.9 2.2 2.3  N 15 15 15 15 15  0 TO 2  MEAN 58. 67. 61. 57. 50.  S.D. 16.8 6.6 14.2 16.0 12.0  S.E. 4.3 1.7 3.7 4.1 3.1  N 15 15 15 15 15  0 TO 3  MEAN 86. 97. 93. 88. 78.  S.D. 23.3 12.8 18.4 18.8 14.7  S.E. 6.0 3.3 4.7 4.8 3.8  N 15 15 15 15 15  0 TO PRIOR TO NECROPSY -A  MEAN 100. 114. 110. 97. 95.  S.D. 29.5 15.2 26.9 33.6 16.2  S.E. 7.6 3.9 7.0 8.7 4.2  N 15 15 15 15 15  ----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett’s test  A = A NON-FASTED WEIGHT WAS RECORDED PRIOR TO NECROPSY FOR ALL ANIMALS IN PHASE I (STUDY WEEK 3) AND PHASE II (STUDY WEEK 3 OR 4) 

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 TABLE 7 (COMBINED PHASES) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF CUMULATIVE BODY WEIGHT CHANGES [G]  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- WEEK 0 TO 1  MEAN 22. 19. 19. 19. 22.  S.D. 6.1 5.2 5.5 6.9 7.2  S.E. 1.6 1.3 1.4 1.8 1.8  N 15 15 15 15 15  0 TO 2  MEAN 35. 36. 37. 37. 37.  S.D. 10.6 9.9 8.8 7.7 8.4  S.E. 2.7 2.6 2.3 2.0 2.2  N 15 15 15 15 15  0 TO 3  MEAN 50. 53. 52. 54. 50.  S.D. 13.5 14.3 7.6 8.6 9.5  S.E. 3.5 3.7 2.0 2.2 2.5  N 15 15 15 15 15  0 TO PRIOR TO NECROPSY -A  MEAN 57. 60. 60. 64. 61.  S.D. 13.7 16.4 12.1 13.2 13.8  S.E. 3.5 4.2 3.1 3.4 3.6  N 15 15 15 15 15  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group  A = A NON-FASTED WEIGHT WAS RECORDED PRIOR TO NECROPSY FOR ALL ANIMALS IN PHASE I (STUDY WEEK 3) AND PHASE II (STUDY WEEK 3 OR 4)  PBFSTv5.30 06/15/2009 R:06/18/2009

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 TABLE 8 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 SUMMARY OF FOOD CONSUMPTION [G/ANIMAL/DAY]----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- WEEK -1 TO 0 MEAN 23. 23. 23. 22. 23. S.D. 1.4 1.9 1.6 1.8 2.1 S.E. 0.4 0.5 0.4 0.5 0.5 N 15 15 15 15 15 0 TO 1 MEAN 22. 23. 22. 21. 20.* S.D. 1.7 2.6 1.9 2.1 2.3 S.E. 0.4 0.7 0.5 0.6 0.6 N 15 15 15 15 15 1 TO 2 MEAN 23. 24. 23. 23. 22. S.D. 2.4 1.9 2.0 2.5 1.8 S.E. 0.6 0.5 0.5 0.6 0.5 N 15 15 15 15 15 2 TO 3 MEAN 24. 24. 24. 24. 23. S.D. 2.8 2.1 2.0 2.8 2.7 S.E. 0.7 0.5 0.5 0.7 0.7 N 15 14 15 15 15-----------------------------------------------------------------------------------------------------------------------------------* = Significantly different from the control group at 0.05 using Dunnett's test

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 TABLE 8 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 SUMMARY OF FOOD CONSUMPTION [G/ANIMAL/DAY]----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- WEEK -1 TO 0 MEAN 17. 16. 17. 17. 17. S.D. 2.4 1.6 1.2 2.2 1.3 S.E. 0.6 0.4 0.3 0.6 0.3 N 15 15 15 15 15 0 TO 1 MEAN 18. 18. 17. 17. 17. S.D. 2.3 1.3 1.3 1.8 1.5 S.E. 0.6 0.3 0.3 0.5 0.4 N 15 15 15 15 15 1 TO 2 MEAN 19. 19. 18. 18. 18. S.D. 2.0 1.9 1.3 2.6 1.9 S.E. 0.5 0.5 0.3 0.7 0.5 N 15 15 15 15 15 2 TO 3 MEAN 19. 19. 19. 19. 18. S.D. 2.2 2.5 1.1 1.1 1.7 S.E. 0.6 0.6 0.3 0.3 0.4 N 15 15 15 15 15-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group PBFSTv5.30 06/15/2009 R:07/13/2009

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- MALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------WHITE CELL (thous/uL) WEEK 3 MEAN 10.17 12.02 11.93 10.99 8.81 % DIFFERENCE 18.2 17.3 8.1 -13.4 S.D. 2.319 3.560 3.861 2.377 1.779 S.E. 1.037 1.592 1.727 1.063 0.796 N 5 5 5 5 5RED CELL (mil/uL) WEEK 3 MEAN 8.45 8.43 8.37 8.02 8.40 % DIFFERENCE -0.2 -0.9 -5.1 -0.6 S.D. 0.333 0.551 0.302 0.859 0.348 S.E. 0.149 0.246 0.135 0.384 0.156 N 5 5 5 5 5HEMOGLOBIN (g/dL) WEEK 3 MEAN 15.9 15.6 15.8 15.1 15.5 % DIFFERENCE -1.9 -0.6 -5.0 -2.5 S.D. 0.73 0.93 0.59 1.36 0.51 S.E. 0.33 0.42 0.27 0.61 0.23 N 5 5 5 5 5HEMATOCRIT (%) WEEK 3 MEAN 44.5 44.3 44.4 42.3 43.6 % DIFFERENCE -0.4 -0.2 -4.9 -2.0 S.D. 2.55 2.11 1.44 4.42 1.91 S.E. 1.14 0.94 0.64 1.98 0.85 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- MALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------MCV (fL) WEEK 3 MEAN 52.6 52.6 53.0 52.8 51.9 % DIFFERENCE 0.0 0.8 0.4 -1.3 S.D. 1.20 2.82 1.07 2.55 1.45 S.E. 0.54 1.26 0.48 1.14 0.65 N 5 5 5 5 5MCH (pg) WEEK 3 MEAN 18.8 18.5 18.8 18.8 18.4 % DIFFERENCE -1.6 0.0 0.0 -2.1 S.D. 0.24 0.97 0.19 0.76 0.30 S.E. 0.11 0.43 0.08 0.34 0.14 N 5 5 5 5 5MCHC (g/dL) WEEK 3 MEAN 35.8 35.3 35.5 35.6 35.5 % DIFFERENCE -1.4 -0.8 -0.6 -0.8 S.D. 0.49 0.96 0.50 0.66 0.60 S.E. 0.22 0.43 0.22 0.29 0.27 N 5 5 5 5 5PLATELET (thous/uL) WEEK 3 MEAN 1224. 1233. 1169. 1193. 1441. % DIFFERENCE 0.7 -4.5 -2.5 17.7 S.D. 141.7 215.4 585.0 151.7 83.1 S.E. 63.4 96.3 261.6 67.8 37.2 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- MALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------PROTIME (seconds) WEEK 3 MEAN 17.0 17.0 17.0 17.3 17.6 % DIFFERENCE 0.0 0.0 1.8 3.5 S.D. 0.80 0.51 0.73 0.49 1.11 S.E. 0.40 0.23 0.33 0.22 0.49 N 4 5 5 5 5APTT (seconds) WEEK 3 MEAN 19.3 21.2 20.3 19.4 20.5 % DIFFERENCE 9.8 5.2 0.5 6.2 S.D. 1.04 1.61 1.44 2.32 3.45 S.E. 0.52 0.72 0.64 1.04 1.54 N 4 5 5 5 5RETICULOCYTE (%) WEEK 3 MEAN 2.0 2.2 2.4 2.6 1.9 % DIFFERENCE 10.0 20.0 30.0 -5.0 S.D. 0.37 0.42 0.78 0.52 0.18 S.E. 0.17 0.19 0.35 0.23 0.08 N 5 5 5 5 5RETIC ABSOLUTE (thous/uL) WEEK 3 MEAN 167.5 180.0 198.5 201.9 163.5 % DIFFERENCE 7.5 18.5 20.5 -2.4 S.D. 26.63 29.48 59.51 21.61 20.99 S.E. 11.91 13.19 26.61 9.67 9.39 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- MALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------NEUTROPHIL (%) WEEK 3 MEAN 13.6 11.9 10.5 16.0 15.5 % DIFFERENCE -12.5 -22.8 17.6 14.0 S.D. 2.75 3.17 4.51 4.44 6.60 S.E. 1.23 1.42 2.02 1.99 2.95 N 5 5 5 5 5LYMPHOCYTE (%) WEEK 3 MEAN 81.9 84.1 85.6 80.6 80.1 % DIFFERENCE 2.7 4.5 -1.6 -2.2 S.D. 3.37 3.48 4.71 4.32 8.43 S.E. 1.51 1.56 2.11 1.93 3.77 N 5 5 5 5 5MONOCYTE (%) WEEK 3 MEAN 2.2 1.9 1.8 1.7 2.4 % DIFFERENCE -13.6 -18.2 -22.7 9.1 S.D. 0.60 0.43 0.38 0.43 1.45 S.E. 0.27 0.19 0.17 0.19 0.65 N 5 5 5 5 5EOSINOPHIL (%) WEEK 3 MEAN 0.9 0.9 0.8 0.7 0.8 % DIFFERENCE 0.0 -11.1 -22.2 -11.1 S.D. 0.38 0.30 0.24 0.22 0.36 S.E. 0.17 0.14 0.11 0.10 0.16 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- MALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------BASOPHIL (%) WEEK 3 MEAN 0.3 0.4 0.4 0.3 0.4 % DIFFERENCE 33.3 33.3 0.0 33.3 S.D. 0.09 0.05 0.11 0.05 0.10 S.E. 0.04 0.02 0.05 0.02 0.04 N 5 5 5 5 5LG UNSTAIN CELL (%) WEEK 3 MEAN 1.0 0.9 0.9 0.8 0.8 % DIFFERENCE -10.0 -10.0 -20.0 -20.0 S.D. 0.29 0.21 0.22 0.18 0.18 S.E. 0.13 0.09 0.10 0.08 0.08 N 5 5 5 5 5NEU ABSOLUTE (thous/uL) WEEK 3 MEAN 1.36 1.39 1.15 1.68 1.30 % DIFFERENCE 2.2 -15.4 23.5 -4.4 S.D. 0.374 0.453 0.339 0.210 0.350 S.E. 0.167 0.202 0.151 0.094 0.157 N 5 5 5 5 5LYMPH ABSOLUTE (thous/uL) WEEK 3 MEAN 8.35 10.15 10.31 8.92 7.15 % DIFFERENCE 21.6 23.5 6.8 -14.4 S.D. 2.000 3.159 3.653 2.331 1.985 S.E. 0.895 1.413 1.633 1.042 0.888 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- MALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------MONO ABSOLUTE (thous/uL) WEEK 3 MEAN 0.23 0.23 0.21 0.19 0.19 % DIFFERENCE 0.0 -8.7 -17.4 -17.4 S.D. 0.070 0.090 0.093 0.081 0.078 S.E. 0.032 0.040 0.042 0.036 0.035 N 5 5 5 5 5EOS ABSOLUTE (thous/uL) WEEK 3 MEAN 0.09 0.10 0.09 0.08 0.07 % DIFFERENCE 11.1 0.0 -11.1 -22.2 S.D. 0.037 0.036 0.024 0.044 0.019 S.E. 0.017 0.016 0.011 0.020 0.008 N 5 5 5 5 5BASO ABSOLUTE (thous/uL) WEEK 3 MEAN 0.04 0.04 0.06 0.03 0.03 % DIFFERENCE 0.0 50.0 -25.0 -25.0 S.D. 0.015 0.018 0.027 0.010 0.015 S.E. 0.007 0.008 0.012 0.004 0.007 N 5 5 5 5 5LUC ABSOLUTE (thous/uL) WEEK 3 MEAN 0.11 0.11 0.10 0.09 0.07 % DIFFERENCE 0.0 -9.1 -18.2 -36.4 S.D. 0.054 0.058 0.043 0.034 0.015 S.E. 0.024 0.026 0.019 0.015 0.007 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- MALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------RED CELLWIDTH (%) WEEK 3 MEAN 12.2 12.4 12.3 12.5 12.6 % DIFFERENCE 1.6 0.8 2.5 3.3 S.D. 0.22 0.50 0.44 0.44 0.51 S.E. 0.10 0.22 0.20 0.20 0.23 N 5 5 5 5 5HGB WIDTH (g/dL) WEEK 3 MEAN 2.55 2.43 2.54 2.51 2.50 % DIFFERENCE -4.7 -0.4 -1.6 -2.0 S.D. 0.155 0.233 0.106 0.132 0.053 S.E. 0.069 0.104 0.047 0.059 0.024 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- FEMALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------WHITE CELL (thous/uL) WEEK 3 MEAN 8.92 7.56 8.89 7.87 7.78 % DIFFERENCE -15.2 -0.3 -11.8 -12.8 S.D. 2.642 2.516 2.477 2.480 3.008 S.E. 1.182 1.125 1.108 1.109 1.345 N 5 5 5 5 5RED CELL (mil/uL) WEEK 3 MEAN 7.91 8.12 7.77 7.79 7.82 % DIFFERENCE 2.7 -1.8 -1.5 -1.1 S.D. 0.351 0.438 0.781 0.675 0.736 S.E. 0.157 0.196 0.349 0.302 0.329 N 5 5 5 5 5HEMOGLOBIN (g/dL) WEEK 3 MEAN 15.0 15.2 14.6 14.7 14.5 % DIFFERENCE 1.3 -2.7 -2.0 -3.3 S.D. 0.47 0.52 1.49 1.27 1.18 S.E. 0.21 0.23 0.67 0.57 0.53 N 5 5 5 5 5HEMATOCRIT (%) WEEK 3 MEAN 41.1 42.0 40.6 40.7 40.1 % DIFFERENCE 2.2 -1.2 -1.0 -2.4 S.D. 1.98 2.18 4.01 3.89 2.84 S.E. 0.89 0.97 1.79 1.74 1.27 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- FEMALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------MCV (fL) WEEK 3 MEAN 52.0 51.8 52.3 52.2 51.5 % DIFFERENCE -0.4 0.6 0.4 -1.0 S.D. 3.12 1.46 1.17 1.06 1.69 S.E. 1.40 0.65 0.52 0.47 0.76 N 5 5 5 5 5MCH (pg) WEEK 3 MEAN 19.0 18.8 18.8 18.8 18.6 % DIFFERENCE -1.1 -1.1 -1.1 -2.1 S.D. 1.07 0.47 0.50 0.41 0.41 S.E. 0.48 0.21 0.22 0.18 0.18 N 5 5 5 5 5MCHC (g/dL) WEEK 3 MEAN 36.6 36.3 36.0 36.0 36.1 % DIFFERENCE -0.8 -1.6 -1.6 -1.4 S.D. 1.25 0.73 0.23 0.73 0.43 S.E. 0.56 0.33 0.10 0.32 0.19 N 5 5 5 5 5PLATELET (thous/uL) WEEK 3 MEAN 1481. 1389. 1514. 1183. 1346. % DIFFERENCE -6.2 2.2 -20.1 -9.1 S.D. 247.7 143.4 102.3 280.0 238.6 S.E. 110.8 64.1 45.8 125.2 106.7 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- FEMALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------PROTIME (seconds) WEEK 3 MEAN 18.1 17.8 17.9 17.4 17.9 % DIFFERENCE -1.7 -1.1 -3.9 -1.1 S.D. 0.59 1.14 0.98 0.56 0.31 S.E. 0.26 0.51 0.44 0.25 0.18 N 5 5 5 5 3APTT (seconds) WEEK 3 MEAN 15.6 16.1 16.1 16.2 15.7 % DIFFERENCE 3.2 3.2 3.8 0.6 S.D. 2.11 0.87 2.63 2.08 1.37 S.E. 0.94 0.39 1.18 0.93 0.79 N 5 5 5 5 3RETICULOCYTE (%) WEEK 3 MEAN 2.1 1.8 2.4 2.0 2.0 % DIFFERENCE -14.3 14.3 -4.8 -4.8 S.D. 0.33 0.45 1.25 0.21 0.45 S.E. 0.15 0.20 0.56 0.09 0.20 N 5 5 5 5 5RETIC ABSOLUTE (thous/uL) WEEK 3 MEAN 168.9 143.0 177.1 149.7 154.5 % DIFFERENCE -15.3 4.9 -11.4 -8.5 S.D. 25.30 34.90 68.34 11.24 26.40 S.E. 11.31 15.61 30.56 5.02 11.81 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- FEMALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------NEUTROPHIL (%) WEEK 3 MEAN 14.1 12.4 11.6 13.3 17.0 % DIFFERENCE -12.1 -17.7 -5.7 20.6 S.D. 10.46 3.93 2.01 7.28 5.28 S.E. 4.68 1.76 0.90 3.26 2.36 N 5 5 5 5 5LYMPHOCYTE (%) WEEK 3 MEAN 82.1 83.5 84.2 82.7 78.2 % DIFFERENCE 1.7 2.6 0.7 -4.8 S.D. 10.82 4.42 1.90 8.47 5.73 S.E. 4.84 1.98 0.85 3.79 2.56 N 5 5 5 5 5MONOCYTE (%) WEEK 3 MEAN 1.6 1.8 1.9 1.8 2.4 % DIFFERENCE 12.5 18.8 12.5 50.0 S.D. 0.49 0.74 0.56 1.02 0.87 S.E. 0.22 0.33 0.25 0.45 0.39 N 5 5 5 5 5EOSINOPHIL (%) WEEK 3 MEAN 0.9 1.2 1.2 1.1 1.3 % DIFFERENCE 33.3 33.3 22.2 44.4 S.D. 0.31 0.38 0.19 0.53 0.33 S.E. 0.14 0.17 0.09 0.24 0.15 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- FEMALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------BASOPHIL (%) WEEK 3 MEAN 0.3 0.3 0.3 0.3 0.3 % DIFFERENCE 0.0 0.0 0.0 0.0 S.D. 0.10 0.07 0.04 0.16 0.08 S.E. 0.04 0.03 0.02 0.07 0.04 N 5 5 5 5 5LG UNSTAIN CELL (%) WEEK 3 MEAN 1.0 0.8 0.8 0.8 0.9 % DIFFERENCE -20.0 -20.0 -20.0 -10.0 S.D. 0.11 0.17 0.19 0.28 0.28 S.E. 0.05 0.07 0.09 0.12 0.13 N 5 5 5 5 5NEU ABSOLUTE (thous/uL) WEEK 3 MEAN 1.19 0.91 1.05 0.94 1.34 % DIFFERENCE -23.5 -11.8 -21.0 12.6 S.D. 0.872 0.417 0.410 0.343 0.634 S.E. 0.390 0.186 0.183 0.154 0.284 N 5 5 5 5 5LYMPH ABSOLUTE (thous/uL) WEEK 3 MEAN 7.42 6.33 7.48 6.62 6.09 % DIFFERENCE -14.7 0.8 -10.8 -17.9 S.D. 2.835 2.093 2.061 2.554 2.443 S.E. 1.268 0.936 0.922 1.142 1.092 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- FEMALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------MONO ABSOLUTE (thous/uL) WEEK 3 MEAN 0.14 0.15 0.16 0.13 0.18 % DIFFERENCE 7.1 14.3 -7.1 28.6 S.D. 0.039 0.108 0.038 0.048 0.071 S.E. 0.017 0.048 0.017 0.022 0.032 N 5 5 5 5 5EOS ABSOLUTE (thous/uL) WEEK 3 MEAN 0.07 0.09 0.11 0.08 0.09 % DIFFERENCE 28.6 57.1 14.3 28.6 S.D. 0.015 0.030 0.036 0.024 0.023 S.E. 0.007 0.014 0.016 0.011 0.010 N 5 5 5 5 5BASO ABSOLUTE (thous/uL) WEEK 3 MEAN 0.03 0.02 0.02 0.03 0.02 % DIFFERENCE -33.3 -33.3 0.0 -33.3 S.D. 0.016 0.011 0.005 0.015 0.011 S.E. 0.007 0.005 0.002 0.007 0.005 N 5 5 5 5 5LUC ABSOLUTE (thous/uL) WEEK 3 MEAN 0.09 0.06 0.07 0.07 0.07 % DIFFERENCE -33.3 -22.2 -22.2 -22.2 S.D. 0.024 0.024 0.023 0.040 0.030 S.E. 0.011 0.011 0.010 0.018 0.014 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group

3DJHRI

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 TABLE 9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 SUMMARY OF HEMATOLOGY VALUES----------------------------------------------------------------------------------------------------------------------------------- FEMALESANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM-----------------------------------------------------------------------------------------------------------------------------------RED CELLWIDTH (%) WEEK 3 MEAN 11.2 11.2 11.6 11.5 11.4 % DIFFERENCE 0.0 3.6 2.7 1.8 S.D. 0.32 0.25 1.08 0.28 0.31 S.E. 0.14 0.11 0.49 0.12 0.14 N 5 5 5 5 5HGB WIDTH (g/dL) WEEK 3 MEAN 2.43 2.39 2.43 2.43 2.45 % DIFFERENCE -1.6 0.0 0.0 0.8 S.D. 0.147 0.040 0.200 0.170 0.071 S.E. 0.066 0.018 0.089 0.076 0.032 N 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER-----------------------------------------------------------------------------------------------------------------------------------None significantly different from control group PCPSv5.27 05/11/2009

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 TABLE 10 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF SERUM CHEMISTRY VALUES  ----------------------------------------------------------------------------------------------------------------------------------- MALES  ANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- ALBUMIN (g/dL)  WEEK 3 MEAN 4.4 4.3 4.3 4.3 4.3  % DIFFERENCE -2.3 -2.3 -2.3 -2.3  S.D. 0.13 0.22 0.13 0.26 0.22  S.E. 0.06 0.10 0.06 0.12 0.10  N 5 5 5 5 5  TOTAL PROTEIN (g/dL)  WEEK 3 MEAN 6.5 6.4 6.4 6.4 6.6  % DIFFERENCE -1.5 -1.5 -1.5 1.5  S.D. 0.30 0.31 0.28 0.22 0.22  S.E. 0.14 0.14 0.12 0.10 0.10  N 5 5 5 5 5  GLOBULIN (g/dL)  WEEK 3 MEAN 2.1 2.1 2.1 2.0 2.2  % DIFFERENCE 0.0 0.0 -4.8 4.8  S.D. 0.30 0.15 0.17 0.09 0.08  S.E. 0.13 0.07 0.07 0.04 0.04  N 5 5 5 5 5  A/G RATIO  WEEK 3 MEAN 2.19 2.09 2.09 2.12 1.97  % DIFFERENCE -4.6 -4.6 -3.2 -10.0  S.D. 0.319 0.142 0.115 0.201 0.145  S.E. 0.143 0.064 0.051 0.090 0.065  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 10 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF SERUM CHEMISTRY VALUES  ----------------------------------------------------------------------------------------------------------------------------------- MALES  ANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- TOTAL BILI (mg/dL)  WEEK 3 MEAN 0.11 0.11 0.11 0.10 0.12  % DIFFERENCE 0.0 0.0 -9.1 9.1  S.D. 0.009 0.018 0.011 0.032 0.018  S.E. 0.004 0.008 0.005 0.014 0.008  N 5 5 5 5 5  UREA NITROGEN (mg/dL)  WEEK 3 MEAN 14.5 12.7 14.8 12.5 11.6  % DIFFERENCE -12.4 2.1 -13.8 -20.0  S.D. 2.11 2.16 2.88 1.65 2.09  S.E. 0.94 0.97 1.29 0.74 0.93  N 5 5 5 5 5  CREATININE (mg/dL)  WEEK 3 MEAN 0.2 0.3 0.2 0.2 0.3  % DIFFERENCE 50.0 0.0 0.0 50.0  S.D. 0.05 0.05 0.08 0.04 0.08  S.E. 0.02 0.02 0.04 0.02 0.04  N 5 5 5 5 5  ALKALINEPHOS’TSE (U/L)  WEEK 3 MEAN 197. 164. 214. 188. 172.  % DIFFERENCE -16.8 8.6 -4.6 -12.7  S.D. 38.9 33.8 48.3 33.4 23.4  S.E. 17.4 15.1 21.6 14.9 10.5  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 10 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3  SUMMARY OF SERUM CHEMISTRY VALUES  ----------------------------------------------------------------------------------------------------------------------------------- MALES  ANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- ALANINE TRANSFER (U/L)  WEEK 3 MEAN 44. 42. 41. 45. 40.  % DIFFERENCE -4.5 -6.8 2.3 -9.1  S.D. 5.1 2.5 8.4 8.1 4.7  S.E. 2.3 1.1 3.7 3.6 2.1  N 5 5 5 5 5  ASPARTATTRANSFER (U/L)  WEEK 3 MEAN 114. 87. 81. 85. 81.  % DIFFERENCE -23.7 -28.9 -25.4 -28.9  S.D. 43.1 7.9 9.5 12.6 10.2  S.E. 19.3 3.5 4.2 5.6 4.6  N 5 5 5 5 5  GLUTAMYLTRANSFER (U/L)  WEEK 3 MEAN 0.1 0.1 0.1 0.1 0.1  % DIFFERENCE 0.0 0.0 0.0 0.0  S.D. 0.09 0.00 0.00 0.00 0.00  S.E. 0.04 0.00 0.00 0.00 0.00  N 5 5 5 5 5  GLUCOSE (mg/dL)  WEEK 3 MEAN 128. 138. 136. 142. 137.  % DIFFERENCE 7.8 6.3 10.9 7.0  S.D. 8.9 10.2 22.0 30.1 36.5  S.E. 4.0 4.6 9.9 13.5 16.3  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 10 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4  SUMMARY OF SERUM CHEMISTRY VALUES  ----------------------------------------------------------------------------------------------------------------------------------- MALES  ANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- CHOLESTEROL (mg/dL)  WEEK 3 MEAN 52. 58. 54. 59. 67.  % DIFFERENCE 11.5 3.8 13.5 28.8  S.D. 16.6 12.4 6.1 19.4 7.3  S.E. 7.4 5.5 2.7 8.7 3.3  N 5 5 5 5 5  CALCIUM (mg/dL)  WEEK 3 MEAN 10.5 10.7 10.7 10.6 10.6  % DIFFERENCE 1.9 1.9 1.0 1.0  S.D. 0.39 0.23 0.27 0.11 0.16  S.E. 0.17 0.10 0.12 0.05 0.07  N 5 5 5 5 5  CHLORIDE (mEq/L)  WEEK 3 MEAN 105. 103. 104. 104. 104.  % DIFFERENCE -1.9 -1.0 -1.0 -1.0  S.D. 0.8 0.7 1.1 1.9 1.3  S.E. 0.4 0.3 0.5 0.9 0.6  N 5 5 5 5 5  PHOSPHORUS (mg/dL)  WEEK 3 MEAN 8.1 8.3 8.2 7.9 7.6  % DIFFERENCE 2.5 1.2 -2.5 -6.2  S.D. 0.36 0.74 0.41 0.15 0.64  S.E. 0.16 0.33 0.19 0.07 0.29  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 10 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5  SUMMARY OF SERUM CHEMISTRY VALUES  ----------------------------------------------------------------------------------------------------------------------------------- MALES  ANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- POTASSIUM (mEq/L)  WEEK 3 MEAN 5.16 5.02 4.85 4.89 4.90  % DIFFERENCE -2.7 -6.0 -5.2 -5.0  S.D. 0.302 0.282 0.744 0.184 0.406  S.E. 0.135 0.126 0.333 0.082 0.182  N 5 5 5 5 5  SODIUM (mEq/L)  WEEK 3 MEAN 145. 145. 144. 143. 144.  % DIFFERENCE 0.0 -0.7 -1.4 -0.7  S.D. 1.6 1.7 1.3 1.5 1.3  S.E. 0.7 0.7 0.6 0.7 0.6  N 5 5 5 5 5  TRIGLYCERIDE (mg/dL)  WEEK 3 MEAN 65. 84. 78. 57. 49.  % DIFFERENCE 29.2 20.0 -12.3 -24.6  S.D. 11.7 13.7 19.0 15.9 10.7  S.E. 5.2 6.1 8.5 7.1 4.8  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 10 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6  SUMMARY OF SERUM CHEMISTRY VALUES  ---------------------------------------------------------------------------------------------------------------------------------- MALES  ANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ---------------------------------------------------------------------------------------------------------------------------------- SORBITOL’GENASE (U/L)  WEEK 3 MEAN 9. 17. 8. 14. 15.  % DIFFERENCE 88.9 -11.1 55.6 66.7  S.D. 3.9 6.5 3.2 9.2 4.1  S.E. 1.7 2.9 1.4 4.1 1.9  N 5 5 5 5 5  ---------------------------------------------------------------------------------------------------------------------------------- U/L = INTERNATIONAL UNIT/LITER  ---------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 10 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7  SUMMARY OF SERUM CHEMISTRY VALUES  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  ANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- ALBUMIN (g/dL)  WEEK 3 MEAN 4.6 4.9 4.8 4.7 4.7  % DIFFERENCE 6.5 4.3 2.2 2.2  S.D. 0.23 0.36 0.30 0.19 0.21  S.E. 0.10 0.16 0.13 0.08 0.09  N 5 5 5 5 5  TOTAL PROTEIN (g/dL)  WEEK 3 MEAN 6.8 7.1 6.9 6.9 6.7  % DIFFERENCE 4.4 1.5 1.5 -1.5  S.D. 0.31 0.26 0.36 0.30 0.41  S.E. 0.14 0.12 0.16 0.14 0.18  N 5 5 5 5 5  GLOBULIN (g/dL)  WEEK 3 MEAN 2.2 2.2 2.1 2.2 2.0  % DIFFERENCE 0.0 -4.5 0.0 -9.1  S.D. 0.17 0.18 0.23 0.16 0.29  S.E. 0.07 0.08 0.10 0.07 0.13  N 5 5 5 5 5  A/G RATIO  WEEK 3 MEAN 2.14 2.25 2.29 2.16 2.37  % DIFFERENCE 5.1 7.0 0.9 10.7  S.D. 0.156 0.342 0.292 0.125 0.336  S.E. 0.070 0.153 0.130 0.056 0.150  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 10 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8  SUMMARY OF SERUM CHEMISTRY VALUES  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  ANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- TOTAL BILI (mg/dL)  WEEK 3 MEAN 0.13 0.14 0.12 0.13 0.11  % DIFFERENCE 7.7 -7.7 0.0 -15.4  S.D. 0.034 0.056 0.026 0.011 0.030  S.E. 0.015 0.025 0.012 0.005 0.014  N 5 5 5 5 5  UREA NITROGEN (mg/dL)  WEEK 3 MEAN 14.4 14.0 13.4 13.0 11.9  % DIFFERENCE -2.8 -6.9 -9.7 -17.4  S.D. 0.61 2.28 2.30 1.54 2.29  S.E. 0.27 1.02 1.03 0.69 1.02  N 5 5 5 5 5  CREATININE (mg/dL)  WEEK 3 MEAN 0.3 0.3 0.3 0.3 0.3  % DIFFERENCE 0.0 0.0 0.0 0.0  S.D. 0.05 0.05 0.05 0.04 0.07  S.E. 0.02 0.02 0.02 0.02 0.03  N 5 5 5 5 5  ALKALINEPHOS’TSE (U/L)  WEEK 3 MEAN 105. 108. 108. 133. 126.  % DIFFERENCE 2.9 2.9 26.7 20.0  S.D. 14.7 23.2 25.9 15.9 9.2  S.E. 6.6 10.4 11.6 7.1 4.1  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 10 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9  SUMMARY OF SERUM CHEMISTRY VALUES  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  ANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- ALANINE TRANSFER (U/L)  WEEK 3 MEAN 35. 42. 37. 40. 46.  % DIFFERENCE 20.0 5.7 14.3 31.4  S.D. 2.3 15.1 6.2 3.8 10.3  S.E. 1.0 6.7 2.8 1.7 4.6  N 5 5 5 5 5  ASPARTATTRANSFER (U/L)  WEEK 3 MEAN 81. 94. 76. 79. 105.  % DIFFERENCE 16.0 -6.2 -2.5 29.6  S.D. 9.3 22.9 6.9 8.3 55.1  S.E. 4.1 10.2 3.1 3.7 24.7  N 5 5 5 5 5  GLUTAMYLTRANSFER (U/L)  WEEK 3 MEAN 0.2 0.2 0.4 0.1 0.2  % DIFFERENCE 0.0 100.0 -50.0 0.0  S.D. 0.13 0.17 0.15 0.00 0.13  S.E. 0.06 0.08 0.07 0.00 0.06  N 5 5 5 5 5  GLUCOSE (mg/dL)  WEEK 3 MEAN 125. 125. 120. 127. 132.  % DIFFERENCE 0.0 -4.0 1.6 5.6  S.D. 18.0 10.5 11.8 5.8 16.6  S.E. 8.0 4.7 5.3 2.6 7.4  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 10 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10  SUMMARY OF SERUM CHEMISTRY VALUES  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  ANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- CHOLESTEROL (mg/dL)  WEEK 3 MEAN 59. 66. 72. 77. 79.  % DIFFERENCE 11.9 22.0 30.5 33.9  S.D. 16.2 7.3 6.3 17.6 7.6  S.E. 7.3 3.3 2.8 7.9 3.4  N 5 5 5 5 5  CALCIUM (mg/dL)  WEEK 3 MEAN 10.9 11.0 11.0 10.8 10.8  % DIFFERENCE 0.9 0.9 -0.9 -0.9  S.D. 0.10 0.36 0.31 0.41 0.21  S.E. 0.04 0.16 0.14 0.18 0.09  N 5 5 5 5 5  CHLORIDE (mEq/L)  WEEK 3 MEAN 103. 103. 103. 103. 104.  % DIFFERENCE 0.0 0.0 0.0 1.0  S.D. 0.8 0.8 1.3 1.5 1.3  S.E. 0.4 0.4 0.6 0.7 0.6  N 5 5 5 5 5  PHOSPHORUS (mg/dL)  WEEK 3 MEAN 7.2 7.4 7.4 7.4 6.4  % DIFFERENCE 2.8 2.8 2.8 -11.1  S.D. 0.65 0.66 0.36 0.84 1.31  S.E. 0.29 0.30 0.16 0.37 0.59  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 10 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11  SUMMARY OF SERUM CHEMISTRY VALUES  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  ANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- POTASSIUM (mEq/L)  WEEK 3 MEAN 4.34 4.43 4.53 4.62 4.58  % DIFFERENCE 2.1 4.4 6.5 5.5  S.D. 0.227 0.158 0.306 0.443 0.618  S.E. 0.101 0.071 0.137 0.198 0.277  N 5 5 5 5 5  SODIUM (mEq/L)  WEEK 3 MEAN 143. 144. 144. 144. 143.  % DIFFERENCE 0.7 0.7 0.7 0.0  S.D. 0.8 1.9 0.8 2.3 0.5  S.E. 0.4 0.8 0.4 1.0 0.2  N 5 5 5 5 5  TRIGLYCERIDE (mg/dL)  WEEK 3 MEAN 48. 55. 51. 60. 50.  % DIFFERENCE 14.6 6.3 25.0 4.2  S.D. 8.1 8.0 10.0 21.3 5.9  S.E. 3.6 3.6 4.5 9.5 2.7  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

3DJHRI

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 TABLE 10 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12  SUMMARY OF SERUM CHEMISTRY VALUES  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  ANALYSIS GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- SORBITOL’GENASE (U/L)  WEEK 3 MEAN 17. 18. 12. 17. 15.  % DIFFERENCE 5.9 -29.4 0.0 -11.8  S.D. 8.0 4.3 3.8 4.0 5.3  S.E. 3.6 1.9 1.7 1.8 2.4  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- U/L = INTERNATIONAL UNIT/LITER  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group  PCPSv5.27 06/10/2009 R:06/10/2009

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 TABLE 11 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF MACROSCOPIC FINDINGS  SCHEDULED NECROPSY  ----------------------------------------------------------------------------------------------------------------------------------- ----- M A L E -----  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS TERMINALLY EUTHANIZED 5 5 5 5 5  KIDNEYS  -DILATED PELVIS 0 1 0 0 0  -AREA(S), DEPRESSED 0 0 1 0 0  -CYST(S) 0 0 1 0 0  LN, MANDIBULAR  -DISCOLORATION, DARK RED 0 1 0 0 1  THYMUS  -AREA(S), DARK RED 1 2 0 1 2  NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 4 3 4 4 3  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM 

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 TABLE 11 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF MACROSCOPIC FINDINGS  SCHEDULED NECROPSY  ----------------------------------------------------------------------------------------------------------------------------------- ----- F E M A L E -----  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS TERMINALLY EUTHANIZED 5 5 5 5 5  LN, AXILLARY  -ENLARGED 0 0 1 0 1  LN, MANDIBULAR  -DISCOLORATION, DARK RED 0 1 0 1 0  SKIN  -HAIR LOSS 0 0 0 0 1  UTERUS  -CONTENTS, CLEAR FLUID 0 1 0 0 1  VAGINA  -CYST(S) 0 0 0 0 1  NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 5 3 4 4 2  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  PGRSI2v4.07 05/11/2009 R:06/18/2009

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 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- FINAL BODY WT (G)  MEAN 364. 394. 363. 365. 355.  % DIFFERENCE 8.2 -0.3 0.3 -2.5  S.D. 28.9 9.6 45.9 63.9 27.6  S.E. 12.9 4.3 20.5 28.6 12.4  N 5 5 5 5 5  ADRENAL GLANDS (G)  MEAN 0.0579 0.0587 0.0635 0.0544 0.0631  % DIFFERENCE 1.4 9.7 -6.0 9.0  S.D. 0.01029 0.00240 0.01842 0.00664 0.00699  S.E. 0.00460 0.00107 0.00824 0.00297 0.00313  N 5 5 5 5 5  ADRENAL GLANDS (G/100 G FINAL BODY WEIGHT)  MEAN 0.016 0.015 0.017 0.015 0.018  % DIFFERENCE -6.3 6.3 -6.3 12.5  S.D. 0.0034 0.0007 0.0040 0.0026 0.0029  S.E. 0.0015 0.0003 0.0018 0.0012 0.0013  N 5 5 5 5 5  ADRENAL GLANDS (G/100 G BRAIN)  MEAN 2.887 2.998 3.182 2.720 3.093  % DIFFERENCE 3.8 10.2 -5.8 7.1  S.D. 0.5790 0.1853 0.9280 0.4241 0.3463  S.E. 0.2589 0.0829 0.4150 0.1897 0.1549  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- BRAIN (G)  MEAN 2.01 1.96 1.99 2.01 2.04  % DIFFERENCE -2.5 -1.0 0.0 1.5  S.D. 0.118 0.121 0.087 0.136 0.036  S.E. 0.053 0.054 0.039 0.061 0.016  N 5 5 5 5 5  BRAIN (G/100 G FINAL BODY WEIGHT)  MEAN 0.553 0.497 0.556 0.559 0.578  % DIFFERENCE -10.1 0.5 1.1 4.5  S.D. 0.0144 0.0209 0.0638 0.0627 0.0407  S.E. 0.0064 0.0094 0.0285 0.0280 0.0182  N 5 5 5 5 5  EPIDIDYMIDES (G)  MEAN 1.08 1.06 1.11 1.10 1.05  % DIFFERENCE -1.9 2.8 1.9 -2.8  S.D. 0.019 0.088 0.109 0.104 0.074  S.E. 0.008 0.040 0.049 0.046 0.033  N 5 5 5 5 5  EPIDIDYMIDES (G/100 G FINAL BODY WEIGHT)  MEAN 0.298 0.270 0.307 0.306 0.296  % DIFFERENCE -9.4 3.0 2.7 -0.7  S.D. 0.0191 0.0238 0.0345 0.0243 0.0237  S.E. 0.0086 0.0107 0.0154 0.0109 0.0106  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- EPIDIDYMIDES (G/100 G BRAIN)  MEAN 53.787 54.444 55.574 54.918 51.214  % DIFFERENCE 1.2 3.3 2.1 -4.8  S.D. 2.3897 6.7932 6.1391 3.3267 3.3467  S.E. 1.0687 3.0380 2.7455 1.4877 1.4967  N 5 5 5 5 5  HEART (G)  MEAN 1.24 1.36 1.34 1.21 1.17  % DIFFERENCE 9.7 8.1 -2.4 -5.6  S.D. 0.201 0.172 0.216 0.296 0.147  S.E. 0.090 0.077 0.097 0.132 0.066  N 5 5 5 5 5  HEART (G/100 G FINAL BODY WEIGHT)  MEAN 0.340 0.344 0.369 0.329 0.329  % DIFFERENCE 1.2 8.5 -3.2 -3.2  S.D. 0.0312 0.0362 0.0293 0.0248 0.0307  S.E. 0.0140 0.0162 0.0131 0.0111 0.0137  N 5 5 5 5 5  HEART (G/100 G BRAIN)  MEAN 61.622 69.156 67.277 59.719 57.084  % DIFFERENCE 12.2 9.2 -3.1 -7.4  S.D. 6.9975 6.7375 10.6019 10.5449 6.9151  S.E. 3.1294 3.0131 4.7413 4.7158 3.0925  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- KIDNEYS (G)  MEAN 2.56 2.56 2.40 2.50 2.44  % DIFFERENCE 0.0 -6.3 -2.3 -4.7  S.D. 0.377 0.179 0.255 0.402 0.158  S.E. 0.169 0.080 0.114 0.180 0.071  N 5 5 5 5 5  KIDNEYS (G/100 G FINAL BODY WEIGHT)  MEAN 0.703 0.649 0.664 0.686 0.691  % DIFFERENCE -7.7 -5.5 -2.4 -1.7  S.D. 0.1008 0.0478 0.0498 0.0497 0.0370  S.E. 0.0451 0.0214 0.0223 0.0222 0.0166  N 5 5 5 5 5  KIDNEYS (G/100 G BRAIN)  MEAN 126.946 130.681 120.324 123.630 119.617  % DIFFERENCE 2.9 -5.2 -2.6 -5.8  S.D. 15.8596 11.4707 12.4172 11.6283 5.8483  S.E. 7.0926 5.1299 5.5532 5.2003 2.6155  N 5 5 5 5 5  LIVER (G)  MEAN 10.46 11.94 10.85 10.98 9.87  % DIFFERENCE 14.1 3.7 5.0 -5.6  S.D. 1.210 1.072 1.647 2.730 1.257  S.E. 0.541 0.480 0.737 1.221 0.562  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- LIVER (G/100 G FINAL BODY WEIGHT)  MEAN 2.866 3.025 2.990 2.983 2.776  % DIFFERENCE 5.5 4.3 4.1 -3.1  S.D. 0.1111 0.2090 0.2028 0.2572 0.2039  S.E. 0.0497 0.0935 0.0907 0.1150 0.0912  N 5 5 5 5 5  LIVER (G/100 G BRAIN)  MEAN 518.714 607.287 543.124 542.837 483.156  % DIFFERENCE 17.1 4.7 4.7 -6.9  S.D. 31.1866 20.1899 71.0051 105.6171 59.4285  S.E. 13.9471 9.0292 31.7544 47.2334 26.5772  N 5 5 5 5 5  LUNGS (G)  MEAN 1.35 1.38 1.36 1.32 1.31  % DIFFERENCE 2.2 0.7 -2.2 -3.0  S.D. 0.115 0.061 0.147 0.150 0.103  S.E. 0.052 0.027 0.066 0.067 0.046  N 5 5 5 5 5  LUNGS (G/100 G FINAL BODY WEIGHT)  MEAN 0.371 0.349 0.375 0.366 0.371  % DIFFERENCE -5.9 1.1 -1.3 0.0  S.D. 0.0263 0.0183 0.0174 0.0336 0.0388  S.E. 0.0117 0.0082 0.0078 0.0150 0.0174  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- LUNGS (G/100 G BRAIN)  MEAN 67.058 70.215 67.988 65.912 64.181  % DIFFERENCE 4.7 1.4 -1.7 -4.3  S.D. 3.4694 4.2653 6.5900 6.5820 5.4203  S.E. 1.5516 1.9075 2.9471 2.9436 2.4240  N 5 5 5 5 5  SPLEEN (G)  MEAN 0.62 0.67 0.68 0.63 0.62  % DIFFERENCE 8.1 9.7 1.6 0.0  S.D. 0.129 0.062 0.144 0.113 0.077  S.E. 0.058 0.028 0.065 0.051 0.034  N 5 5 5 5 5  SPLEEN (G/100 G FINAL BODY WEIGHT)  MEAN 0.170 0.169 0.185 0.173 0.177  % DIFFERENCE -0.6 8.8 1.8 4.1  S.D. 0.0275 0.0145 0.0255 0.0215 0.0245  S.E. 0.0123 0.0065 0.0114 0.0096 0.0110  N 5 5 5 5 5  SPLEEN (G/100 G BRAIN)  MEAN 30.677 34.009 33.946 31.025 30.528  % DIFFERENCE 10.9 10.7 1.1 -0.5  S.D. 5.1897 2.2141 7.4208 3.9442 3.4286  S.E. 2.3209 0.9902 3.3187 1.7639 1.5333  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

3DJHRI

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 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- TESTES (G)  MEAN 3.22 3.34 3.16 3.39 3.16  % DIFFERENCE 3.7 -1.9 5.3 -1.9  S.D. 0.139 0.218 0.292 0.330 0.208  S.E. 0.062 0.098 0.130 0.147 0.093  N 5 5 5 5 5  TESTES (G/100 G FINAL BODY WEIGHT)  MEAN 0.885 0.848 0.879 0.939 0.896  % DIFFERENCE -4.2 -0.7 6.1 1.2  S.D. 0.0401 0.0497 0.0952 0.0769 0.1012  S.E. 0.0179 0.0222 0.0426 0.0344 0.0453  N 5 5 5 5 5  TESTES (G/100 G BRAIN)  MEAN 159.983 170.807 158.985 168.535 154.818  % DIFFERENCE 6.8 -0.6 5.3 -3.2  S.D. 4.2767 15.2567 16.7786 9.1278 11.1440  S.E. 1.9126 6.8230 7.5036 4.0821 4.9838  N 5 5 5 5 5  THYROIDS/PARATHY (G)  MEAN 0.0209 0.0193 0.0187 0.0192 0.0185  % DIFFERENCE -7.7 -10.5 -8.1 -11.5  S.D. 0.00244 0.00481 0.00134 0.00441 0.00215  S.E. 0.00109 0.00215 0.00060 0.00197 0.00096  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- THYROIDS/PARATHY (G/100 G FINAL BODY WEIGHT)  MEAN 0.006 0.005 0.005 0.005 0.005  % DIFFERENCE -16.7 -16.7 -16.7 -16.7  S.D. 0.0004 0.0011 0.0004 0.0004 0.0004  S.E. 0.0002 0.0005 0.0002 0.0002 0.0002  N 5 5 5 5 5  THYROIDS/PARATHY (G/100 G BRAIN)  MEAN 1.036 0.978 0.940 0.949 0.906  % DIFFERENCE -5.6 -9.3 -8.4 -12.5  S.D. 0.0722 0.2055 0.0734 0.1649 0.1055  S.E. 0.0323 0.0919 0.0328 0.0737 0.0472  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- FINAL BODY WT (G)  MEAN 261. 233. 253. 239. 233.  % DIFFERENCE -10.7 -3.1 -8.4 -10.7  S.D. 31.6 17.5 9.3 18.0 20.1  S.E. 14.2 7.8 4.2 8.0 9.0  N 5 5 5 5 5  ADRENAL GLANDS (G)  MEAN 0.0734 0.0631 0.0718 0.0661 0.0663  % DIFFERENCE -14.0 -2.2 -9.9 -9.7  S.D. 0.01017 0.00455 0.00417 0.01034 0.01347  S.E. 0.00455 0.00203 0.00187 0.00462 0.00602  N 5 5 5 5 5  ADRENAL GLANDS (G/100 G FINAL BODY WEIGHT)  MEAN 0.028 0.027 0.028 0.028 0.028  % DIFFERENCE -3.6 0.0 0.0 0.0  S.D. 0.0020 0.0033 0.0011 0.0045 0.0040  S.E. 0.0009 0.0015 0.0005 0.0020 0.0018  N 5 5 5 5 5  ADRENAL GLANDS (G/100 G BRAIN)  MEAN 3.865 3.396 3.714 3.417 3.474  % DIFFERENCE -12.1 -3.9 -11.6 -10.1  S.D. 0.5314 0.1772 0.2879 0.5591 0.6250  S.E. 0.2377 0.0793 0.1287 0.2501 0.2795  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- BRAIN (G)  MEAN 1.90 1.86 1.94 1.94 1.90  % DIFFERENCE -2.1 2.1 2.1 0.0  S.D. 0.079 0.047 0.078 0.062 0.128  S.E. 0.035 0.021 0.035 0.028 0.057  N 5 5 5 5 5  BRAIN (G/100 G FINAL BODY WEIGHT)  MEAN 0.736 0.799 0.768 0.813 0.819  % DIFFERENCE 8.6 4.3 10.5 11.3  S.D. 0.0882 0.0592 0.0489 0.0672 0.0443  S.E. 0.0395 0.0265 0.0219 0.0300 0.0198  N 5 5 5 5 5  HEART (G)  MEAN 0.96 0.87 0.99 0.94 0.91  % DIFFERENCE -9.4 3.1 -2.1 -5.2  S.D. 0.143 0.040 0.181 0.097 0.172  S.E. 0.064 0.018 0.081 0.044 0.077  N 5 5 5 5 5  HEART (G/100 G FINAL BODY WEIGHT)  MEAN 0.368 0.373 0.394 0.393 0.390  % DIFFERENCE 1.4 7.1 6.8 6.0  S.D. 0.0110 0.0269 0.0728 0.0261 0.0613  S.E. 0.0049 0.0120 0.0325 0.0117 0.0274  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- HEART (G/100 G BRAIN)  MEAN 50.767 46.802 51.473 48.635 47.512  % DIFFERENCE -7.8 1.4 -4.2 -6.4  S.D. 7.5055 2.6946 10.2006 5.0644 6.1423  S.E. 3.3566 1.2050 4.5618 2.2649 2.7469  N 5 5 5 5 5  KIDNEYS (G)  MEAN 1.86 1.73 1.80 1.73 1.69  % DIFFERENCE -7.0 -3.2 -7.0 -9.1  S.D. 0.164 0.086 0.120 0.132 0.159  S.E. 0.074 0.039 0.053 0.059 0.071  N 5 5 5 5 5  KIDNEYS (G/100 G FINAL BODY WEIGHT)  MEAN 0.718 0.741 0.713 0.723 0.728  % DIFFERENCE 3.2 -0.7 0.7 1.4  S.D. 0.0605 0.0392 0.0553 0.0577 0.0741  S.E. 0.0270 0.0175 0.0247 0.0258 0.0331  N 5 5 5 5 5  KIDNEYS (G/100 G BRAIN)  MEAN 98.089 93.075 92.950 89.239 89.001  % DIFFERENCE -5.1 -5.2 -9.0 -9.3  S.D. 7.3742 5.9099 4.3237 9.0010 9.5819  S.E. 3.2979 2.6430 1.9336 4.0254 4.2852  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- LIVER (G)  MEAN 7.51 6.58 7.56 7.37 7.51  % DIFFERENCE -12.4 0.7 -1.9 0.0  S.D. 1.103 0.784 0.228 0.825 0.614  S.E. 0.493 0.351 0.102 0.369 0.275  N 5 5 5 5 5  LIVER (G/100 G FINAL BODY WEIGHT)  MEAN 2.874 2.814 2.997 3.074 3.227**  % DIFFERENCE -2.1 4.3 7.0 12.3  S.D. 0.1561 0.1837 0.1233 0.1488 0.0779  S.E. 0.0698 0.0821 0.0551 0.0665 0.0348  N 5 5 5 5 5  LIVER (G/100 G BRAIN)  MEAN 396.104 354.913 391.113 380.493 394.693  % DIFFERENCE -10.4 -1.3 -3.9 -0.4  S.D. 61.1821 46.5245 16.9746 40.7642 17.9969  S.E. 27.3614 20.8064 7.5913 18.2303 8.0485  N 5 5 5 5 5  LUNGS (G)  MEAN 1.16 1.00 1.10 1.10 1.09  % DIFFERENCE -13.8 -5.2 -5.2 -6.0  S.D. 0.050 0.079 0.078 0.087 0.131  S.E. 0.022 0.035 0.035 0.039 0.059  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- ** = Significantly different from the control group at 0.01 using Dunnett’s test 

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 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- LUNGS (G/100 G FINAL BODY WEIGHT)  MEAN 0.450 0.431 0.437 0.461 0.469  % DIFFERENCE -4.2 -2.9 2.4 4.2  S.D. 0.0396 0.0267 0.0441 0.0437 0.0335  S.E. 0.0177 0.0119 0.0197 0.0196 0.0150  N 5 5 5 5 5  LUNGS (G/100 G BRAIN)  MEAN 61.386 54.159 56.941 56.908 57.313  % DIFFERENCE -11.8 -7.2 -7.3 -6.6  S.D. 4.4422 5.0144 3.8061 6.3175 4.4896  S.E. 1.9866 2.2425 1.7021 2.8253 2.0078  N 5 5 5 5 5  OVARIES/OVIDUCTS (G)  MEAN 0.1390 0.1241 0.1369 0.1422 0.1266  % DIFFERENCE -10.7 -1.5 2.3 -8.9  S.D. 0.01545 0.02132 0.00304 0.02094 0.02386  S.E. 0.00691 0.00953 0.00136 0.00936 0.01067  N 5 5 5 5 5  OVARIES/OVIDUCTS (G/100 G FINAL BODY WEIGHT)  MEAN 0.054 0.053 0.054 0.059 0.055  % DIFFERENCE -1.9 0.0 9.3 1.9  S.D. 0.0081 0.0060 0.0034 0.0058 0.0120  S.E. 0.0036 0.0027 0.0015 0.0026 0.0054  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- OVARIES/OVIDUCTS (G/100 G BRAIN)  MEAN 7.325 6.686 7.081 7.341 6.655  % DIFFERENCE -8.7 -3.3 0.2 -9.1  S.D. 0.8829 1.1291 0.2680 1.1010 1.2037  S.E. 0.3948 0.5049 0.1199 0.4924 0.5383  N 5 5 5 5 5  SPLEEN (G)  MEAN 0.57 0.50 0.57 0.44* 0.44*  % DIFFERENCE -12.3 0.0 -22.8 -22.8  S.D. 0.100 0.046 0.044 0.054 0.085  S.E. 0.045 0.020 0.020 0.024 0.038  N 5 5 5 5 5  SPLEEN (G/100 G FINAL BODY WEIGHT)  MEAN 0.218 0.213 0.224 0.184 0.190  % DIFFERENCE -2.3 2.8 -15.6 -12.8  S.D. 0.0172 0.0233 0.0146 0.0247 0.0243  S.E. 0.0077 0.0104 0.0065 0.0111 0.0109  N 5 5 5 5 5  SPLEEN (G/100 G BRAIN)  MEAN 29.976 26.745 29.232 22.575** 23.277*  % DIFFERENCE -10.8 -2.5 -24.7 -22.3  S.D. 4.9253 2.6353 1.8083 2.3611 3.8163  S.E. 2.2027 1.1786 0.8087 1.0559 1.7067  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- * = Significantly different from the control group at 0.05 using Dunnett’s test  ** = Significantly different from the control group at 0.01 using Dunnett’s test 

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 TABLE 12 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15  SUMMARY OF ORGAN WEIGHTS AND RELATIVE ORGAN WEIGHTS  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- THYROIDS/PARATHY (G)  MEAN 0.0178 0.0161 0.0179 0.0172 0.0148  % DIFFERENCE -9.6 0.6 -3.4 -16.9  S.D. 0.00159 0.00291 0.00255 0.00431 0.00070  S.E. 0.00071 0.00130 0.00114 0.00193 0.00031  N 5 5 5 5 5  THYROIDS/PARATHY (G/100 G FINAL BODY WEIGHT)  MEAN 0.007 0.007 0.007 0.007 0.006  % DIFFERENCE 0.0 0.0 0.0 -14.3  S.D. 0.0007 0.0011 0.0007 0.0019 0.0005  S.E. 0.0003 0.0005 0.0003 0.0009 0.0002  N 5 5 5 5 5  THYROIDS/PARATHY (G/100 G BRAIN)  MEAN 0.936 0.867 0.921 0.893 0.784  % DIFFERENCE -7.4 -1.6 -4.6 -16.2  S.D. 0.0971 0.1555 0.1048 0.2443 0.0719  S.E. 0.0434 0.0695 0.0469 0.1093 0.0322  N 5 5 5 5 5  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group  POFBSTv5.15 05/07/2009

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 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  ADRENAL CORTEX  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ADRENAL MEDULLA  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  AORTA  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  CECUM  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  COLON  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  DUODENUM  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

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 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  EPIDIDYMIDES  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ESOPHAGUS  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  EYES  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 4 NA NA NA 5  -INFLAMMATION, ACUTE 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE FEMUR  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  HARDERIAN GLANDS  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 4 NA NA NA 4  -HEMORRHAGE 0 NA NA NA 1  MINIMAL NONE NA NA NA 1  -INFILTRATE, MONONUCLEAR 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

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 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  HEART  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 4 NA NA NA 3  -CARDIOMYOPATHY 1 NA NA NA 2  MINIMAL 1 NA NA NA 2  ILEUM  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  JEJUNUM  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  JOINT  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  KIDNEYS  TOTAL NUMBER EXAMINED 5 5 5 5 5  EXAMINED, UNREMARKABLE 4 2 2 4 5  -DILATATION, PELVIS 0 1 0 0 0  PRESENT NONE 1 NONE NONE NONE -NEPHROPATHY, CHRONIC PROGRESSIVE 1 2 3 1 0  MINIMAL 1 2 3 1 NONE ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

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 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  LAC. GLAND EXOR  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  LARYNX  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  LIVER  TOTAL NUMBER EXAMINED 5 5 5 5 5  EXAMINED, UNREMARKABLE 2 1 3 4 1  -INFILTRATE, MONONUCLEAR 3 4 2 1 4  MINIMAL 3 4 2 1 4  LN, AXILLARY  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  LN, BRONCHIAL  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  LN, MANDIBULAR  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 4  -HEMORRHAGE 0 NA NA NA 1  MINIMAL NONE NA NA NA 1  LN, MEDIASTINAL  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  LN, MESENTERIC  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  LUNGS  TOTAL NUMBER EXAMINED 5 5 5 5 5  EXAMINED, UNREMARKABLE 4 1 3 3 4  -HISTIOCYTOSIS, ALVEOLAR 1 1 1 0 1  MINIMAL 1 1 1 NONE 1  -INFILTRATE, MONONUCLEAR 0 3 2 2 0  MINIMAL NONE 3 2 2 NONE ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  MARROW, FEMUR  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  MARROW, STERN  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  NASAL LEVEL I  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 2  -INFILTRATE, NEUTROPHIL 0 NA NA NA 2  MINIMAL NONE NA NA NA 2  -METAPLASIA, SQUAMOUS 0 NA NA NA 1  MINIMAL NONE NA NA NA 1  -PERIODONTITIS 0 NA NA NA 1  MILD NONE NA NA NA 1  NASAL LEVEL II  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 4  -HYPERPLASIA, GOBLET CELL 0 NA NA NA 1  MINIMAL NONE NA NA NA 1  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  NASAL LEVEL III  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 4  -INFLAMMATION, ACUTE 0 NA NA NA 1  MILD NONE NA NA NA 1  NASAL LEVEL IV  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 3 NA NA NA 3  -INFLAMMATION, ACUTE 0 NA NA NA 1  MILD NONE NA NA NA 1  -METAPLASIA, SQUAMOUS 2 NA NA NA 1  MINIMAL 2 NA NA NA 1  NASAL LEVEL V  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  NASAL LEVEL VI  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  NERVE, SCIATIC  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  NERVES, OPTIC  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  PANCREAS  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 4 NA NA NA 5  -INFILTRATE, MONONUCLEAR 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE PARATHYROIDS  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  PEYER’S PATCHES  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  PHARYNX  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  PITUITARY  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  PROSTATE  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 4 NA NA NA 5  -INFILTRATE, MONONUCLEAR 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE RECTUM  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  SAL. GLAND MAND  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  SEMINAL VESICLES  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  SKELETAL MUSCLE  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 4  -INFILTRATE, MONONUCLEAR 0 NA NA NA 1  MINIMAL NONE NA NA NA 1  SKIN  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  SPINAL CORD  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  SPLEEN  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  STERNEBRAE  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  STOMACH, GLAN  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  STOMACH, NON  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  TESTES  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 3  -ATROPHY 0 NA NA NA 2  MINIMAL NONE NA NA NA 2  THYMUS  TOTAL NUMBER EXAMINED 5 2 NA 1 5  EXAMINED, UNREMARKABLE 4 0 NA 0 3  -HEMORRHAGE 1 2 NA 1 2  MINIMAL 1 2 NA 1 2  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  THYROID GLANDS  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  TRACHEA  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  URINARY BLADDER  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  ADRENAL CORTEX  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ADRENAL MEDULLA  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  AORTA  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  CECUM  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  CERVIX  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  COLON  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  DUODENUM  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ESOPHAGUS  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  EYES  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  FEMUR  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  HARDERIAN GLANDS  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  HEART  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 4 NA NA NA 5  -CARDIOMYOPATHY 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  ILEUM  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  JEJUNUM  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  JOINT  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  KIDNEYS  TOTAL NUMBER EXAMINED 5 5 5 5 5  EXAMINED, UNREMARKABLE 2 3 5 5 5  -CYST 0 1 0 0 0  PRESENT NONE 1 NONE NONE NONE -MINERALIZATION, MEDULLARY 1 2 0 0 0  MINIMAL 1 1 NONE NONE NONE MILD NONE 1 NONE NONE NONE -NEPHROPATHY, CHRONIC PROGRESSIVE 2 1 0 0 0  MINIMAL 2 1 NONE NONE NONE ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  LAC. GLAND EXOR  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  LARYNX  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 4 NA NA NA 5  -INFILTRATE, MONONUCLEAR 1 NA NA NA 0  MILD 1 NA NA NA NONE LIVER  TOTAL NUMBER EXAMINED 5 5 5 5 5  EXAMINED, UNREMARKABLE 3 1 0 1 2  -INFILTRATE, MONONUCLEAR 2 4 5 4 3  MINIMAL 2 4 5 4 3  -NECROSIS 0 1 0 0 0  MINIMAL NONE 1 NONE NONE NONE LN, AXILLARY  TOTAL NUMBER EXAMINED 5 NA 1 NA 5  EXAMINED, UNREMARKABLE 5 NA 1 NA 5  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  LN, BRONCHIAL  TOTAL NUMBER EXAMINED 4 NA NA NA 3  EXAMINED, UNREMARKABLE 3 NA NA NA 3  NOT PRESENT FOR EXAMINATION 1 NA NA NA 2  -HEMORRHAGE 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE LN, MANDIBULAR  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  LN, MEDIASTINAL  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 3 NA NA NA 3  -HEMORRHAGE 2 NA NA NA 2  MINIMAL 2 NA NA NA 2  LN, MESENTERIC  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  LUNGS  TOTAL NUMBER EXAMINED 5 5 5 5 5  EXAMINED, UNREMARKABLE 4 3 2 4 4  -HISTIOCYTOSIS, ALVEOLAR 0 1 0 0 0  MINIMAL NONE 1 NONE NONE NONE ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  LUNGS - CONTINUED  -INFILTRATE, MONONUCLEAR 1 1 3 1 1  MINIMAL 1 1 3 1 1  MAMMARY GLAND  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  MARROW, FEMUR  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  MARROW, STERN  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  NASAL LEVEL I  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 2 NA NA NA 5  -HYPERPLASIA, GOBLET CELL 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE -INFILTRATE, MIXED INFLAMMATORY CELL 2 NA NA NA 0  MINIMAL 2 NA NA NA NONE -INFLAMMATION, ACUTE 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  NASAL LEVEL I - CONTINUED  -METAPLASIA, SQUAMOUS 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE NASAL LEVEL II  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  NASAL LEVEL III  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  NASAL LEVEL IV  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  NASAL LEVEL V  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  NASAL LEVEL VI  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  NERVE, SCIATIC  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  NERVES, OPTIC  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  OVARIES  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 4  -CYST 0 NA NA NA 1  PRESENT NONE NA NA NA 1  OVIDUCTS  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  PANCREAS  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 21  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  PARATHYROIDS  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  PEYER’S PATCHES  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  PHARYNX  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  PITUITARY  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  RECTUM  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  SAL. GLAND MAND  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 4 NA NA NA 5  -INFILTRATE, MONONUCLEAR 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 22  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  SKELETAL MUSCLE  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  SKIN  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  SPINAL CORD  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  SPLEEN  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  STERNEBRAE  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  STOMACH, GLAN  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 23  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  STOMACH, NON  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  THYMUS  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  THYROID GLANDS  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  TRACHEA  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  URINARY BLADDER  TOTAL NUMBER EXAMINED 5 NA NA NA 5  EXAMINED, UNREMARKABLE 5 NA NA NA 5  UTERUS  TOTAL NUMBER EXAMINED 5 1 NA NA 5  EXAMINED, UNREMARKABLE 5 0 NA NA 4  -DILATATION, LUMEN 0 1 NA NA 1  MILD NONE NA NA NA 1  MODERATE NONE 1 NA NA NONE ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 13 (PHASE I) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 24  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS EXAMINED 5 5 5 5 5  VAGINA  TOTAL NUMBER EXAMINED 5 1 NA NA 5  EXAMINED, UNREMARKABLE 0 0 NA NA 0  -ESTROUS CYCLE: DIESTRUS 2 0 NA NA 3  PRESENT 2 NA NA NA 3  -ESTROUS CYCLE: ESTRUS 1 1 NA NA 0  PRESENT 1 1 NA NA NONE -ESTROUS CYCLE: PROESTRUS 2 0 NA NA 2  PRESENT 2 NA NA NA 2  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE  PHSI2v4.30 06/05/2009 R:06/18/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 14 (HOME CAGE OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST HOME CAGE OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 POSTURE  SITTING OR STANDING NORMALLY 0 4 1 1 3 ASLEEP, LYING ON SIDE OR CURLED UP 6 4 5 5 6 ALERT, ORIENTED TOWARD OBSERVER 1 1 2 0 0 SITTING, HEAD HELD LOW 3 1 2 4 1 CONVULSIONS - CLONIC  ABSENT 10 10 10 10 10 CONVULSIONS - TONIC  ABSENT 10 10 10 10 10 TREMORS  NONE 10 10 10 10 10 BITING  NONE 10 10 10 10 10 PALPEBRAL CLOSURE  EYELIDS WIDE OPEN 3 5 4 4 3 EYELIDS SLIGHTLY DROOPING 2 1 1 0 1 DROOPING EYELIDS (HALF-CLOSED) 1 0 0 2 1 EYELIDS COMPLETELY SHUT 4 4 5 4 5 FECES CONSISTENCY  PELLETS 5 7 3 4 6 PELLETS ABSENT 5 3 7 6 4 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

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 TABLE 14 (HOME CAGE OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST HOME CAGE OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 POSTURE  SITTING OR STANDING NORMALLY 4 2 3 4 5 ASLEEP, LYING ON SIDE OR CURLED UP 2 6 3 4 1 ALERT, ORIENTED TOWARD OBSERVER 3 1 3 0 1 SITTING, HEAD HELD LOW 1 1 1 2 3 REARING 1 1 0 0 0 CONVULSIONS - CLONIC  ABSENT 10 10 10 10 10 CONVULSIONS - TONIC  ABSENT 10 10 10 10 10 TREMORS  NONE 10 10 10 10 10 BITING  NONE 10 10 10 10 10 PALPEBRAL CLOSURE  EYELIDS WIDE OPEN 7 3 7 5 7 EYELIDS SLIGHTLY DROOPING 1 0 0 0 2 DROOPING EYELIDS (HALF-CLOSED) 1 2 0 2 1 EYELIDS COMPLETELY SHUT 1 5 3 3 0 FECES CONSISTENCY  PELLETS 6 4 4 2 4 PELLETS ABSENT 4 6 6 8 6 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  PFOBSUv4.31 05/07/2009

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 TABLE 15 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  HOME CAGE OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 9 10 POSTURE  SITTING OR STANDING NORMALLY 4 1 0 4 5 ASLEEP, LYING ON SIDE OR CURLED UP 2 3 3 2 2 ALERT, ORIENTED TOWARD OBSERVER 2 3 4 2 2 SITTING, HEAD HELD LOW 2 3 2 1 1 REARING 1 1 2 2 2 CONVULSIONS - CLONIC  ABSENT 10 10 10 9 10 CONVULSIONS - TONIC  ABSENT 10 10 10 9 10 TREMORS  NONE 10 10 10 9 10 BITING  NONE 10 10 10 9 10 PALPEBRAL CLOSURE  EYELIDS WIDE OPEN 6 6 5 6 7 EYELIDS SLIGHTLY DROOPING 1 0 2 1 1 DROOPING EYELIDS (HALF-CLOSED) 1 1 2 0 0 EYELIDS COMPLETELY SHUT 2 3 1 2 2 FECES CONSISTENCY  PELLETS 2 3 3 3 4 PELLETS ABSENT 8 7 7 6 6 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

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 TABLE 15 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  HOME CAGE OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 POSTURE  SITTING OR STANDING NORMALLY 4 3 3 1 4 ASLEEP, LYING ON SIDE OR CURLED UP 0 1 1 1 1 ALERT, ORIENTED TOWARD OBSERVER 5 4 5 6 4 SITTING, HEAD HELD LOW 1 1 0 1 1 REARING 4 5 5 5 2 CONVULSIONS - CLONIC  ABSENT 10 10 10 10 10 CONVULSIONS - TONIC  ABSENT 10 10 10 10 10 TREMORS  NONE 10 10 10 10 10 BITING  NONE 9 10 10 10 10 BITING OF CAGE 1 0 0 0 0 PALPEBRAL CLOSURE  EYELIDS WIDE OPEN 10 9 9 8 8 EYELIDS SLIGHTLY DROOPING 0 0 0 0 1 DROOPING EYELIDS (HALF-CLOSED) 0 0 0 1 1 EYELIDS COMPLETELY SHUT 0 1 1 1 0 FECES CONSISTENCY  PELLETS 1 3 2 1 4 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

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 TABLE 15 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  HOME CAGE OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 FECES CONSISTENCY (CONTINUED)  PELLETS ABSENT 9 7 8 9 6 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  PFOBSUv4.31 05/07/2009

3DJHRI

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 TABLE 16 (HANDLING OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST HANDLING OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 EASE OF REMOVAL  VERY EASY: ANIMAL SITS QUIETLY, ALLOWS INVESTIGATOR TO PICK IT UP 10 8 9 9 9 EASY: WITH/WITHOUT VOCALIZATION, WITHOUT RESISTANCE OR SLIGHT RESISTANCE 0 2 1 1 1 EASE OF HANDLING IN HAND  NO RESISTANCE, ANIMAL IS EASY TO HANDLE 10 7 10 8 10 SLIGHT RESISTANCE TO BEING HANDLED, WITH/WITHOUT VOCALIZATION 0 3 0 2 0 LACRIMATION  NONE 10 10 10 10 10 CHROMODACRYORRHEA  ABSENT 10 10 10 10 10 SALIVATION  NONE 10 10 10 10 10 PILOERECTION  NONE 10 10 10 10 10 FUR APPEARANCE  NORMAL: CLEAN AND GROOMED 10 10 10 10 10 PALPEBRAL CLOSURE  EYELIDS WIDE OPEN 10 10 10 10 10 RESPIRATORY RATE  NORMAL: BY OBSERVATION (80-110/MIN.) 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

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 TABLE 16 (HANDLING OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST HANDLING OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 RESPIRATORY CHARACTER  NORMAL 10 10 10 10 10 RED DEPOSITS - eyes  ABSENT 10 10 10 10 10 RED DEPOSITS - nose  ABSENT 10 10 10 10 10 RED DEPOSITS - mouth  ABSENT 10 10 10 10 10 CRUSTY DEPOSITS - eyes  ABSENT 10 10 10 10 10 CRUSTY DEPOSITS - nose  ABSENT 10 10 10 10 10 CRUSTY DEPOSITS - mouth  ABSENT 10 10 10 10 10 MUCOUS MEMBRANES - color  PINK 10 10 10 10 10 EYES - color  PINK 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

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 TABLE 16 (HANDLING OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST HANDLING OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 SKIN - color  PINK 10 10 10 10 10 EYE PROMINENCE  NORMAL 10 10 10 10 10 MUSCLE TONE  MUSCLE IS FIRM BUT NOT HARD (NORMAL) 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

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 TABLE 16 (HANDLING OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST HANDLING OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 EASE OF REMOVAL  VERY EASY: ANIMAL SITS QUIETLY, ALLOWS INVESTIGATOR TO PICK IT UP 7 8 8 10 9 EASY: WITH/WITHOUT VOCALIZATION, WITHOUT RESISTANCE OR SLIGHT RESISTANCE 3 2 2 0 1 EASE OF HANDLING IN HAND  NO RESISTANCE, ANIMAL IS EASY TO HANDLE 10 10 9 10 10 SLIGHT RESISTANCE TO BEING HANDLED, WITH/WITHOUT VOCALIZATION 0 0 1 0 0 LACRIMATION  NONE 10 10 10 10 10 CHROMODACRYORRHEA  ABSENT 10 10 10 10 10 SALIVATION  NONE 10 10 10 10 10 PILOERECTION  NONE 10 10 10 10 10 FUR APPEARANCE  NORMAL: CLEAN AND GROOMED 10 10 10 10 10 PALPEBRAL CLOSURE  EYELIDS WIDE OPEN 10 10 10 10 10 RESPIRATORY RATE  NORMAL: BY OBSERVATION (80-110/MIN.) 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

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 TABLE 16 (HANDLING OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST HANDLING OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 RESPIRATORY CHARACTER  NORMAL 10 10 10 10 10 RED DEPOSITS - eyes  ABSENT 10 10 10 10 10 RED DEPOSITS - nose  ABSENT 10 10 10 10 10 RED DEPOSITS - mouth  ABSENT 10 10 10 10 10 CRUSTY DEPOSITS - eyes  ABSENT 10 10 10 10 10 CRUSTY DEPOSITS - nose  ABSENT 10 10 10 10 10 CRUSTY DEPOSITS - mouth  ABSENT 10 10 10 10 10 MUCOUS MEMBRANES - color  PINK 10 10 10 10 10 EYES - color  PINK 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

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 TABLE 16 (HANDLING OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST HANDLING OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 SKIN - color  PINK 10 10 10 10 10 EYE PROMINENCE  NORMAL 10 10 10 10 10 MUSCLE TONE  MUSCLE IS FIRM BUT NOT HARD (NORMAL) 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  PFOBSUv4.31 05/07/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 17 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  HANDLING OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 9 10 EASE OF REMOVAL  VERY EASY: ANIMAL SITS QUIETLY, ALLOWS INVESTIGATOR TO PICK IT UP 8 10 10 7 9 EASY: WITH/WITHOUT VOCALIZATION, WITHOUT RESISTANCE OR SLIGHT RESISTANCE 2 0 0 2 1 EASE OF HANDLING IN HAND  NO RESISTANCE, ANIMAL IS EASY TO HANDLE 8 9 9 8 10 SLIGHT RESISTANCE TO BEING HANDLED, WITH/WITHOUT VOCALIZATION 2 1 1 1 0 LACRIMATION  NONE 10 10 10 9 10 CHROMODACRYORRHEA  ABSENT 10 10 10 9 10 SALIVATION  NONE 10 10 10 9 10 PILOERECTION  NONE 10 10 10 9 10 FUR APPEARANCE  NORMAL: CLEAN AND GROOMED 10 10 10 8 10 SLIGHTLY SOILED 0 0 0 1 0 PALPEBRAL CLOSURE  EYELIDS WIDE OPEN 10 10 10 9 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

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 TABLE 17 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  HANDLING OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 9 10 RESPIRATORY RATE  NORMAL: BY OBSERVATION (80-110/MIN.) 10 10 10 9 10 RESPIRATORY CHARACTER  NORMAL 10 10 10 9 10 RED DEPOSITS - eyes  ABSENT 10 10 10 9 10 RED DEPOSITS - nose  ABSENT 10 10 10 9 10 RED DEPOSITS - mouth  ABSENT 10 10 10 9 10 CRUSTY DEPOSITS - eyes  ABSENT 10 10 10 9 10 CRUSTY DEPOSITS - nose  PRESENT 1 0 0 1 0 ABSENT 9 10 10 8 10 CRUSTY DEPOSITS - mouth  ABSENT 10 10 10 9 10 MUCOUS MEMBRANES - color  PINK 10 10 10 9 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 17 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  HANDLING OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 9 10 EYES - color  PINK 10 10 10 9 10 SKIN - color  PINK 10 10 10 9 10 EYE PROMINENCE  NORMAL 10 10 10 9 10 MUSCLE TONE  MUSCLE IS FIRM BUT NOT HARD (NORMAL) 10 10 10 9 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 17 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  HANDLING OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 EASE OF REMOVAL  VERY EASY: ANIMAL SITS QUIETLY, ALLOWS INVESTIGATOR TO PICK IT UP 10 10 10 10 10 EASE OF HANDLING IN HAND  NO RESISTANCE, ANIMAL IS EASY TO HANDLE 10 10 10 10 10 LACRIMATION  NONE 10 10 10 10 10 CHROMODACRYORRHEA  ABSENT 10 10 10 10 10 SALIVATION  NONE 10 10 10 10 10 PILOERECTION  NONE 10 10 10 10 10 FUR APPEARANCE  NORMAL: CLEAN AND GROOMED 10 10 10 10 10 PALPEBRAL CLOSURE  EYELIDS WIDE OPEN 10 10 10 10 10 RESPIRATORY RATE  NORMAL: BY OBSERVATION (80-110/MIN.) 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

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 TABLE 17 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  HANDLING OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 RESPIRATORY CHARACTER  NORMAL 10 10 10 10 10 RED DEPOSITS - eyes  PRESENT 0 0 0 0 1 ABSENT 10 10 10 10 9 RED DEPOSITS - nose  ABSENT 10 10 10 10 10 RED DEPOSITS - mouth  ABSENT 10 10 10 10 10 CRUSTY DEPOSITS - eyes  ABSENT 10 10 10 10 10 CRUSTY DEPOSITS - nose  PRESENT 0 0 1 0 0 ABSENT 10 10 9 10 10 CRUSTY DEPOSITS - mouth  ABSENT 10 10 10 10 10 MUCOUS MEMBRANES - color  PINK 10 10 10 10 10 EYES - color  PINK 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 17 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  HANDLING OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 SKIN - color  PINK 10 10 10 10 10 EYE PROMINENCE  NORMAL 10 10 10 10 10 MUSCLE TONE  MUSCLE IS FIRM BUT NOT HARD (NORMAL) 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  PFOBSUv4.31 05/07/2009

3DJHRI

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 TABLE 18 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST OPEN FIELD OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 TIME TO FIRST STEP (seconds) : MEAN 1.0 0.9 0.9 0.9 1.1 S.D. 0.70 0.86 0.50 0.53 1.04 MOBILITY  NORMAL 10 10 10 10 10 GAIT  NORMAL 10 10 10 10 10 CONVULSIONS - CLONIC  ABSENT 10 10 10 10 10 CONVULSIONS - TONIC  ABSENT 10 10 10 10 10 TREMORS  NONE 10 10 10 10 10 GAIT SCORE  NORMAL 10 10 10 10 10 AROUSAL  NORMAL: ALERT, EXPLORATORY MOVEMENTS 10 10 10 10 10 BIZARRE/STEREOTYPIC BEHAVIOR  NONE 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

3DJHRI

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 TABLE 18 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST OPEN FIELD OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 REARING : MEAN 7.1 8.0 8.1 6.0 6.5 S.D. 3.28 2.16 2.96 5.35 2.59 BACKING : MEAN 0.0 0.0 0.0 0.0 0.0 S.D. 0.00 0.00 0.00 0.00 0.00 GROOMING : MEAN 0.2 0.3 0.1 0.2 0.3 S.D. 0.42 0.48 0.32 0.42 0.67 URINATION : MEAN 0.3 0.3 0.3 0.4 0.5 S.D. 0.48 0.48 0.48 0.52 0.71 DEFECATION : MEAN 0.1 0.5 0.1 0.3 0.9 S.D. 0.32 0.97 0.32 0.67 1.91 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 18 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST OPEN FIELD OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 TIME TO FIRST STEP (seconds) : MEAN 0.7 0.8 0.6 0.6 0.7 S.D. 0.37 0.49 0.27 0.24 0.37 MOBILITY  NORMAL 10 10 10 10 10 GAIT  NORMAL 10 10 10 10 10 CONVULSIONS - CLONIC  ABSENT 10 10 10 10 10 CONVULSIONS - TONIC  ABSENT 10 10 10 10 10 TREMORS  NONE 10 10 10 10 10 GAIT SCORE  NORMAL 10 10 10 10 10 AROUSAL  NORMAL: ALERT, EXPLORATORY MOVEMENTS 10 10 10 10 10 BIZARRE/STEREOTYPIC BEHAVIOR  NONE 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

3DJHRI

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 TABLE 18 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST OPEN FIELD OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 REARING : MEAN 9.1 8.0 9.2 7.9 10.6 S.D. 2.28 3.62 4.02 2.38 2.07 BACKING : MEAN 0.0 0.0 0.0 0.0 0.0 S.D. 0.00 0.00 0.00 0.00 0.00 GROOMING : MEAN 0.2 0.1 0.2 0.3 0.0 S.D. 0.42 0.32 0.42 0.48 0.00 URINATION : MEAN 0.2 0.2 0.2 0.3 0.1 S.D. 0.42 0.42 0.42 0.48 0.32 DEFECATION : MEAN 0.0 0.0 0.0 0.1 0.0 S.D. 0.00 0.00 0.00 0.32 0.00 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST  PFOBSUv4.31 05/11/2009

3DJHRI

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 TABLE 19 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  OPEN FIELD OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 9 10 TIME TO FIRST STEP (seconds) : MEAN 0.8 0.7 0.8 1.0 0.6 S.D. 0.39 0.25 0.37 0.41 0.28 MOBILITY  NORMAL 10 10 10 9 10 GAIT  NORMAL 10 10 10 9 10 CONVULSIONS - CLONIC  ABSENT 10 10 10 9 10 CONVULSIONS - TONIC  ABSENT 10 10 10 9 10 TREMORS  NONE 10 10 10 9 10 GAIT SCORE  NORMAL 10 10 10 9 10 AROUSAL  NORMAL: ALERT, EXPLORATORY MOVEMENTS 10 10 10 9 10 BIZARRE/STEREOTYPIC BEHAVIOR  NONE 10 10 10 9 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 19 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  OPEN FIELD OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 9 10 REARING : MEAN 7.9 7.6 9.6 7.1 9.0 S.D. 5.09 3.63 3.50 4.23 5.35 BACKING : MEAN 0.0 0.0 0.0 0.0 0.0 S.D. 0.00 0.00 0.00 0.00 0.00 GROOMING : MEAN 0.0 0.1 0.1 0.2 0.2 S.D. 0.00 0.32 0.32 0.44 0.42 URINATION : MEAN 0.3 0.6 0.9 0.6 0.8 S.D. 0.48 0.52 0.32 0.53 0.92 DEFECATION : MEAN 0.7 1.1 0.0 0.8 0.3 S.D. 1.64 2.42 0.00 1.72 0.95 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 19 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  OPEN FIELD OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 TIME TO FIRST STEP (seconds) : MEAN 0.5 0.7 0.5 0.6 0.6 S.D. 0.26 0.38 0.11 0.23 0.32 MOBILITY  NORMAL 10 10 10 10 10 GAIT  NORMAL 10 10 10 10 10 CONVULSIONS - CLONIC  ABSENT 10 10 10 10 10 CONVULSIONS - TONIC  ABSENT 10 10 10 10 10 TREMORS  NONE 10 10 10 10 10 GAIT SCORE  NORMAL 10 10 10 10 10 AROUSAL  NORMAL: ALERT, EXPLORATORY MOVEMENTS 10 9 10 9 10 SOMEWHAT HIGH: SLIGHT EXCITEMENT, TENSE, SUDDEN DARTING OR FREEZING 0 1 0 1 0 BIZARRE/STEREOTYPIC BEHAVIOR  NONE 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 19 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  OPEN FIELD OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 REARING : MEAN 12.3 14.7 13.7 12.3 12.3 S.D. 4.11 4.90 4.90 7.09 2.67 BACKING : MEAN 0.0 0.0 0.0 0.0 0.0 S.D. 0.00 0.00 0.00 0.00 0.00 GROOMING : MEAN 0.1 0.3 0.2 0.0 0.0 S.D. 0.32 0.48 0.42 0.00 0.00 URINATION : MEAN 0.0 0.0 0.3 0.1 0.2 S.D. 0.00 0.00 0.67 0.32 0.42 DEFECATION : MEAN 0.0 0.0 0.0 0.0 0.1 S.D. 0.00 0.00 0.00 0.00 0.32 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST  PFOBSUv4.31 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 20 (SENSORY OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST SENSORY OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 APPROACH RESPONSE  NO REACTION 0 1 2 2 0 SLOW APPROACH, SNIFFING OR TURNING AWAY 10 8 8 8 10 MORE ENERGETIC RESPONSE THAN (2), WITH/WITHOUT VOCALIZATION 0 1 0 0 0 TOUCH RESPONSE  ANIMAL MAY SLOWLY TURN, WALK AWAY 10 10 10 10 10 STARTLE RESPONSE  SLIGHT REACTION, EAR FLICK OR SOME EVIDENCE THAT SNAP WAS HEARD 10 10 10 10 10 TAIL PINCH RESPONSE  ANIMAL MAY SLOWLY TURN, WALK AWAY 9 9 10 10 10 MORE ENERGETIC RESPONSE THAN (2), WITH/WITHOUT VOCALIZATION 1 1 0 0 0 OLFACTORY ORIENTATION  REACTION PRESENT: ANIMAL APPROACHES SWAB MAKING SNIFFING MOVEMENTS WITH NOSE 10 10 10 10 10 PUPIL RESPONSE  PUPIL RESPONSE PRESENT 10 10 10 10 10 EYEBLINK RESPONSE  EYEBLINK RESPONSE PRESENT 10 10 10 10 10 FORELIMB EXTENSION  FORELIMB EXTENSION PRESENT 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  COMPLETE SCORING CRITERIA PRESENTED AS AN APPENDIX  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 20 (SENSORY OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST SENSORY OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 HINDLIMB EXTENSION  HINDLIMB EXTENSION PRESENT 10 10 10 10 10 AIR RIGHTING REFLEX  NORMAL 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  COMPLETE SCORING CRITERIA PRESENTED AS AN APPENDIX  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 20 (SENSORY OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST SENSORY OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 APPROACH RESPONSE  NO REACTION 0 1 0 1 1 SLOW APPROACH, SNIFFING OR TURNING AWAY 9 9 10 8 8 MORE ENERGETIC RESPONSE THAN (2), WITH/WITHOUT VOCALIZATION 1 0 0 1 1 TOUCH RESPONSE  ANIMAL MAY SLOWLY TURN, WALK AWAY 9 10 10 10 10 MORE ENERGETIC RESPONSE THAN (2), WITH/WITHOUT VOCALIZATION 1 0 0 0 0 STARTLE RESPONSE  SLIGHT REACTION, EAR FLICK OR SOME EVIDENCE THAT SNAP WAS HEARD 10 10 9 10 10 MORE ENERGETIC RESPONSE THAN (2), WITH/WITHOUT VOCALIZATION 0 0 1 0 0 TAIL PINCH RESPONSE  NO REACTION 0 1 0 0 0 ANIMAL MAY SLOWLY TURN, WALK AWAY 9 8 9 8 9 MORE ENERGETIC RESPONSE THAN (2), WITH/WITHOUT VOCALIZATION 1 1 1 2 1 OLFACTORY ORIENTATION  REACTION PRESENT: ANIMAL APPROACHES SWAB MAKING SNIFFING MOVEMENTS WITH NOSE 10 10 10 10 10 PUPIL RESPONSE  PUPIL RESPONSE PRESENT 10 10 10 10 10 EYEBLINK RESPONSE  EYEBLINK RESPONSE PRESENT 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  COMPLETE SCORING CRITERIA PRESENTED AS AN APPENDIX  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 20 (SENSORY OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST SENSORY OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 FORELIMB EXTENSION  FORELIMB EXTENSION PRESENT 10 10 10 10 10 HINDLIMB EXTENSION  HINDLIMB EXTENSION PRESENT 10 10 10 10 10 AIR RIGHTING REFLEX  NORMAL 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  COMPLETE SCORING CRITERIA PRESENTED AS AN APPENDIX  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  PFOBSUv4.31 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 21 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  SENSORY OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 9 10 APPROACH RESPONSE  NO REACTION 3 0 2 1 2 SLOW APPROACH, SNIFFING OR TURNING AWAY 7 10 8 8 8 TOUCH RESPONSE  NO REACTION 0 0 0 1 1 ANIMAL MAY SLOWLY TURN, WALK AWAY 10 10 10 8 9 STARTLE RESPONSE  NO REACTION 0 0 0 1 0 SLIGHT REACTION, EAR FLICK OR SOME EVIDENCE THAT SNAP WAS HEARD 10 10 10 8 10 TAIL PINCH RESPONSE  NO REACTION 3 1 0 1 1 ANIMAL MAY SLOWLY TURN, WALK AWAY 7 8 10 8 6 MORE ENERGETIC RESPONSE THAN (2), WITH/WITHOUT VOCALIZATION 0 1 0 0 3 OLFACTORY ORIENTATION  REACTION PRESENT: ANIMAL APPROACHES SWAB MAKING SNIFFING MOVEMENTS WITH NOSE 10 10 10 9 10 PUPIL RESPONSE  PUPIL RESPONSE PRESENT 10 10 10 9 10 EYEBLINK RESPONSE  EYEBLINK RESPONSE PRESENT 10 10 10 9 10 FORELIMB EXTENSION  FORELIMB EXTENSION PRESENT 10 10 10 9 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  COMPLETE SCORING CRITERIA PRESENTED AS AN APPENDIX  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 21 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  SENSORY OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 9 10 HINDLIMB EXTENSION  HINDLIMB EXTENSION PRESENT 10 10 10 9 10 AIR RIGHTING REFLEX  NORMAL 10 10 10 9 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  COMPLETE SCORING CRITERIA PRESENTED AS AN APPENDIX  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 21 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  SENSORY OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 APPROACH RESPONSE  NO REACTION 0 1 0 1 1 SLOW APPROACH, SNIFFING OR TURNING AWAY 10 9 10 9 9 TOUCH RESPONSE  NO REACTION 0 1 0 0 0 ANIMAL MAY SLOWLY TURN, WALK AWAY 10 9 10 10 10 STARTLE RESPONSE  SLIGHT REACTION, EAR FLICK OR SOME EVIDENCE THAT SNAP WAS HEARD 10 10 10 10 10 TAIL PINCH RESPONSE  ANIMAL MAY SLOWLY TURN, WALK AWAY 9 8 10 8 9 MORE ENERGETIC RESPONSE THAN (2), WITH/WITHOUT VOCALIZATION 1 2 0 2 1 OLFACTORY ORIENTATION  REACTION PRESENT: ANIMAL APPROACHES SWAB MAKING SNIFFING MOVEMENTS WITH NOSE 10 10 10 10 10 PUPIL RESPONSE  PUPIL RESPONSE PRESENT 10 10 10 10 10 EYEBLINK RESPONSE  EYEBLINK RESPONSE PRESENT 10 10 10 10 10 FORELIMB EXTENSION  FORELIMB EXTENSION PRESENT 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  COMPLETE SCORING CRITERIA PRESENTED AS AN APPENDIX  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 21 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  SENSORY OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5 ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10 HINDLIMB EXTENSION  HINDLIMB EXTENSION PRESENT 10 10 10 10 10 AIR RIGHTING REFLEX  NORMAL 10 10 10 10 10 ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  COMPLETE SCORING CRITERIA PRESENTED AS AN APPENDIX  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  PFOBSUv4.31 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 22 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST NEUROMUSCULAR OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10  HINDLIMB EXTENSOR STRENGTH  HINDLIMB RESISTANCE PRESENT 10 10 10 10 10  GRIP STRENGTH (g) - FORE/HINDLIMB FORE: MEAN 613.2 612.4 619.4 623.6 600.2  S.D. 67.78 86.97 197.80 171.52 125.65  HIND: MEAN 221.3 200.5 202.5 184.8 229.8  S.D. 37.01 71.10 67.28 43.32 68.86  ROTAROD PERFORMANCE (seconds) : MEAN 62.4 83.9 65.5 74.7 59.6  S.D. 48.33 46.73 51.51 49.12 35.68  HINDLIMB FOOTSPLAY (mm) : MEAN 47.3 63.3 57.3 60.9 57.7  S.D. 12.23 10.77 9.25 21.06 13.42  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 22 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST NEUROMUSCULAR OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10  HINDLIMB EXTENSOR STRENGTH  HINDLIMB RESISTANCE PRESENT 10 10 10 10 10  GRIP STRENGTH (g) - FORE/HINDLIMB FORE: MEAN 571.4 576.4 595.8 628.4 560.0  S.D. 111.30 154.69 124.35 102.84 80.71  HIND: MEAN 275.2 220.4 208.2 214.9 237.9  S.D. 72.04 49.33 75.89 38.23 77.56  ROTAROD PERFORMANCE (seconds) : MEAN 78.6 82.9 65.7 75.7 43.2  S.D. 45.23 44.82 48.27 48.36 40.22  HINDLIMB FOOTSPLAY (mm) : MEAN 45.1 36.5 45.6 48.8 41.0  S.D. 16.68 14.59 14.50 13.71 7.10  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST  PFOBSUv4.31 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 23 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  NEUROMUSCULAR OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 9 10  HINDLIMB EXTENSOR STRENGTH  HINDLIMB RESISTANCE PRESENT 10 10 10 9 10  GRIP STRENGTH (g) - FORE/HINDLIMB FORE: MEAN 849.4 940.1 845.5 830.6 900.2  S.D. 196.33 200.96 157.17 126.60 198.49  HIND: MEAN 461.8 500.4 531.0 401.6 444.0  S.D. 144.11 217.41 177.66 112.42 136.08  ROTAROD PERFORMANCE (seconds) : MEAN 45.8 57.5 43.0 94.3 82.9  S.D. 46.24 46.78 47.42 50.11 46.59  HINDLIMB FOOTSPLAY (mm) : MEAN 74.4 75.8 68.0 78.2 74.9  S.D. 17.30 19.36 19.43 14.93 14.72  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 23 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  NEUROMUSCULAR OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10  HINDLIMB EXTENSOR STRENGTH  HINDLIMB RESISTANCE PRESENT 10 10 10 10 10  GRIP STRENGTH (g) - FORE/HINDLIMB FORE: MEAN 782.8 653.0 744.4 821.9 699.5  S.D. 164.69 131.82 252.68 164.96 159.11  HIND: MEAN 490.6 387.3 408.9 424.3 386.3  S.D. 89.56 112.62 179.11 145.91 94.43  ROTAROD PERFORMANCE (seconds) : MEAN 85.9 101.8 56.4 64.9 61.6  S.D. 45.22 38.44 44.20 47.78 51.76  HINDLIMB FOOTSPLAY (mm) : MEAN 62.5 63.1 60.0 65.4 58.7  S.D. 12.70 19.50 15.63 19.58 7.10  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS AT THE 0.05 LEVEL USING FISHER’S EXACT TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST  PFOBSUv4.31 05/11/2009

3DJHRI

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 TABLE 24 (PHYSIOLOGICAL OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST PHYSIOLOGICAL OBSERVATIONS  MALES  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10  CATALEPSY (seconds) : MEAN 0.4 0.4 0.6 0.6 0.4  S.D. 0.14 0.13 0.30 0.28 0.15  N 10 10 10 10 10  BODY TEMPERATURE (degrees C) : MEAN 37.0 36.9 36.8 37.3 37.5  S.D. 0.68 0.86 0.60 0.79 0.99  N 10 10 10 10 10  BODY WEIGHT (g) : MEAN 234.3 233.4 236.6 234.0 237.7  S.D. 24.02 28.01 23.72 26.62 22.50  N 10 10 10 10 10  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 24 (PHYSIOLOGICAL OBSERVATIONS - PRETEST - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST PHYSIOLOGICAL OBSERVATIONS  FEMALES  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10  CATALEPSY (seconds) : MEAN 0.4 0.4 0.3 0.4 0.4  S.D. 0.15 0.15 0.12 0.07 0.08  N 10 10 10 10 10  BODY TEMPERATURE (degrees C) : MEAN 38.4 38.2 38.1 38.1 38.4  S.D. 0.67 0.62 1.04 0.90 0.66  N 10 10 10 10 10  BODY WEIGHT (g) : MEAN 172.1 179.7 174.4 178.5 176.8  S.D. 15.22 14.30 18.43 16.74 14.66  N 10 10 10 10 10  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST  PFOBSUv4.31 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 25 (PHYSIOLOGICAL OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  PHYSIOLOGICAL OBSERVATIONS  MALES  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 9 10  CATALEPSY (seconds) : MEAN 0.6 0.4 1.2 0.4 0.5  S.D. 0.43 0.16 2.37 0.12 0.18  N 10 10 10 9 10  BODY TEMPERATURE (degrees C) : MEAN 37.4 37.1 37.2 37.7 37.5  S.D. 1.14 0.91 0.90 1.54 0.80  N 10 10 10 9 10  BODY WEIGHT (g) : MEAN 378.5 385.3 390.6 371.5 367.6  S.D. 45.44 27.90 27.61 26.77 27.20  N 10 10 10 9 10  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 25 (PHYSIOLOGICAL OBSERVATIONS - WEEK 3 - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA WEEK 3  PHYSIOLOGICAL OBSERVATIONS  FEMALES  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER TESTED: 10 10 10 10 10  CATALEPSY (seconds) : MEAN 0.4 0.4 0.4 0.5 0.4  S.D. 0.15 0.23 0.07 0.31 0.11  N 10 10 10 10 10  BODY TEMPERATURE (degrees C) : MEAN 38.8 38.7 38.5 38.4 38.6  S.D. 0.68 0.59 0.78 0.84 0.80  N 10 10 10 10 10  BODY WEIGHT (g) : MEAN 242.3 257.6 248.4 262.4 255.2  S.D. 16.30 22.38 17.56 16.30 20.72  N 10 10 10 10 10  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST  PFOBSUv4.31 05/11/2009 R:05/12/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
	



 	
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 TABLE 27 (UNSCHEDULED DEATHS - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1  SUMMARY OF MACROSCOPIC FINDINGS  FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS  ----------------------------------------------------------------------------------------------------------------------------------- ----- M A L E -----  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS EXAMINED 0 0 0 1 0  STOMACH  -AREA(S), DARK RED 0 0 0 1 0  NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 0 0 0 0 0  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 27 (UNSCHEDULED DEATHS - PHASE II) 

 PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2  SUMMARY OF MACROSCOPIC FINDINGS  FOUND DEAD OR EUTHANIZED MORIBUND OR IN EXTREMIS  ----------------------------------------------------------------------------------------------------------------------------------- ----- F E M A L E -----  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS EXAMINED 0 0 0 0 1  NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 0 0 0 0 1  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  PGRSI2v4.07 05/11/2009 R:05/12/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 28 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 1  SUMMARY OF MACROSCOPIC FINDINGS  SCHEDULED NECROPSY  ----------------------------------------------------------------------------------------------------------------------------------- ----- M A L E -----  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS TERMINALLY EUTHANIZED 10 10 10 9 10  NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 10 10 10 9 10  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM 

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 28 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 2  SUMMARY OF MACROSCOPIC FINDINGS  SCHEDULED NECROPSY  ----------------------------------------------------------------------------------------------------------------------------------- ----- F E M A L E -----  GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS TERMINALLY EUTHANIZED 10 10 10 10 9  BRAIN  -AREA(S), DEPRESSED 1 0 0 0 0  NO SIGNIFICANT CHANGES OBSERVED - ALL EXAMINED TISSUES 9 10 10 10 9  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  PGRSI2v4.07 06/05/2009

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 29 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 1  SUMMARY OF BRAIN WEIGHTS AND BRAIN MEASUREMENTS  ----------------------------------------------------------------------------------------------------------------------------------- MALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- BRAIN (G)  MEAN 2.11 2.17 2.15 2.12 2.12  % DIFFERENCE 2.8 1.9 0.5 0.5  S.D. 0.139 0.091 0.083 0.114 0.132  S.E. 0.044 0.029 0.026 0.038 0.042  N 10 10 10 9 10  BRAIN LENGTH(MM)  MEAN 21.1 21.5 21.4 21.4 21.5  S.D. 0.60 0.45 0.51 0.47 0.51  S.E. 0.19 0.14 0.16 0.16 0.16  N 10 10 10 9 10  BRAIN WIDTH(MM)  MEAN 15.3 15.5 15.4 15.6 15.5  S.D. 0.47 0.24 0.28 0.32 0.37  S.E. 0.15 0.08 0.09 0.11 0.12  N 10 10 10 9 10  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group 

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 29 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 2  SUMMARY OF BRAIN WEIGHTS AND BRAIN MEASUREMENTS  ----------------------------------------------------------------------------------------------------------------------------------- FEMALES  GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM  ----------------------------------------------------------------------------------------------------------------------------------- BRAIN (G)  MEAN 2.00 2.03 2.02 2.08 2.06  % DIFFERENCE 1.5 1.0 4.0 3.0  S.D. 0.119 0.092 0.113 0.042 0.108  S.E. 0.038 0.029 0.036 0.013 0.036  N 10 10 10 10 9  BRAIN LENGTH(MM)  MEAN 20.8 21.1 20.9 21.1 21.1  S.D. 0.74 0.55 0.63 0.43 0.36  S.E. 0.23 0.17 0.20 0.14 0.12  N 10 10 10 10 9  BRAIN WIDTH(MM)  MEAN 15.2 15.3 15.2 15.3 15.4  S.D. 0.19 0.20 0.37 0.25 0.35  S.E. 0.06 0.06 0.12 0.08 0.12  N 10 10 10 10 9  ----------------------------------------------------------------------------------------------------------------------------------- None significantly different from control group  POFBSTv5.15 06/05/2009 R:06/10/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 30 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 1  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS EXAMINED 6 0 0 0 6  BASAL GANGLIA  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  CEREBELLUM  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  CEREBRAL CORTEX  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  CERV. DOR. FIB.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  CERV. DOR. GANG.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  CERV. VENT. FIB.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 30 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 2  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS EXAMINED 6 0 0 0 6  EYES  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  GASTROC. MUSCLE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  HIPPOCAMPUS  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  HYPOTHALAMUS  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  LUMBAR DOR. FIB.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  LUMBAR DOR. GANG  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 30 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 3  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS EXAMINED 6 0 0 0 6  LUMBAR VENT. FIB  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 5 NA NA NA 6  -DEGENERATION, AXONAL 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE MEDULLA OBLONG.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  MIDBRAIN  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  OLFACTORY BULBS  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  OPTIC NERVE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 30 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 4  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS EXAMINED 6 0 0 0 6  PERONEAL NERVE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  PONS  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  SCIATIC NERVE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  SPINAL C.-CERV.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  SPINAL C.-LUMB.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  SURAL NERVE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 30 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 5  SUMMARY OF MICROSCOPIC FINDINGS  ----- MALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS EXAMINED 6 0 0 0 6  THALAMUS  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  TIBIAL NERVE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  TRIG. GANGLION  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  TRIGEMINAL NERVE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 30 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 6  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS EXAMINED 6 0 0 0 6  BASAL GANGLIA  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  CEREBELLUM  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  CEREBRAL CORTEX  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  CERV. DOR. FIB.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  CERV. DOR. GANG.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  CERV. VENT. FIB.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 30 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 7  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS EXAMINED 6 0 0 0 6  EYES  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 5 NA NA NA 6  -DYSPLASIA, RETINAL 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE GASTROC. MUSCLE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  HIPPOCAMPUS  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  HYPOTHALAMUS  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  LUMBAR DOR. FIB.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 30 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 8  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS EXAMINED 6 0 0 0 6  LUMBAR DOR. GANG  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  LUMBAR VENT. FIB  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 5 NA NA NA 6  -DEGENERATION, AXONAL 1 NA NA NA 0  MINIMAL 1 NA NA NA NONE MEDULLA OBLONG.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  MIDBRAIN  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  OLFACTORY BULBS  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 30 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 9  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS EXAMINED 6 0 0 0 6  OPTIC NERVE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  PERONEAL NERVE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  PONS  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  SCIATIC NERVE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  SPINAL C.-CERV.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  SPINAL C.-LUMB.  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE 30 (SCHEDULED NECROPSY - PHASE II) 

 PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 10  SUMMARY OF MICROSCOPIC FINDINGS  ----- FEMALE -----  ----------------------------------------------------------------------------------------------------------------------------------- GROUP: 1 2 3 4 5  ----------------------------------------------------------------------------------------------------------------------------------- NUMBER OF ANIMALS IN DOSE GROUP 10 10 10 10 10  NUMBER OF ANIMALS EXAMINED 6 0 0 0 6  SURAL NERVE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  THALAMUS  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  TIBIAL NERVE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  TRIG. GANGLION  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  TRIGEMINAL NERVE  TOTAL NUMBER EXAMINED 6 NA NA NA 6  EXAMINED, UNREMARKABLE 6 NA NA NA 6  ----------------------------------------------------------------------------------------------------------------------------------- 1- 0 PPM 2- 1000 PPM 3- 1500 PPM 4- 2000 PPM 5- 2500 PPM  NA = NOT APPLICABLE  PHSI2v4.30 06/05/2009 R:06/18/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
	
	


	



	   	 







 
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534015

APPENDIX A

	

 
 

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3774 M 0 PPM NORMAL 02-18-09 13:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3774 M 0 PPM DISPOSITION 03-23-09 7:57 P SCHEDULED EUTHANASIA 3776 M 0 PPM NORMAL 02-18-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3776 M 0 PPM DISPOSITION 03-26-09 7:58 P SCHEDULED EUTHANASIA 3780 M 0 PPM NORMAL 02-18-09 13:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3780 M 0 PPM DISPOSITION 03-23-09 7:53 P SCHEDULED EUTHANASIA 3787 M 0 PPM NORMAL 02-18-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3787 M 0 PPM DISPOSITION 03-27-09 6:52 P SCHEDULED EUTHANASIA 3787 M 0 PPM BODY/INTEGUMENT 03-11-09 6:22 1 HAIR LOSS RIGHT FORELIMB 03-18-09 6:36 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:14 1 HAIR LOSS RIGHT FORELIMB-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3787 M 0 PPM BODY/INTEGUMENT 03-25-09 6:14 1 HAIR LOSS LEFT FORELIMB 03-27-09 6:22 1 HAIR LOSS RIGHT FORELIMB 3789 M 0 PPM NORMAL 02-18-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3789 M 0 PPM DISPOSITION 03-27-09 10:11 P SCHEDULED EUTHANASIA 3790 M 0 PPM NORMAL 02-18-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3790 M 0 PPM DISPOSITION 03-27-09 10:12 P SCHEDULED EUTHANASIA 3791 M 0 PPM NORMAL 02-18-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3791 M 0 PPM DISPOSITION 03-27-09 10:12 P SCHEDULED EUTHANASIA 3802 M 0 PPM NORMAL 02-18-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3802 M 0 PPM NORMAL 03-11-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3802 M 0 PPM DISPOSITION 03-27-09 10:12 P SCHEDULED EUTHANASIA 3803 M 0 PPM NORMAL 02-18-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3803 M 0 PPM DISPOSITION 03-24-09 7:39 P SCHEDULED EUTHANASIA 3811 M 0 PPM NORMAL 02-18-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3811 M 0 PPM DISPOSITION 03-27-09 10:12 P SCHEDULED EUTHANASIA 3826 M 0 PPM NORMAL 02-18-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3826 M 0 PPM DISPOSITION 03-26-09 7:57 P SCHEDULED EUTHANASIA 3828 M 0 PPM NORMAL 02-18-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3828 M 0 PPM NORMAL 02-25-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3828 M 0 PPM DISPOSITION 03-25-09 7:49 P SCHEDULED EUTHANASIA 3832 M 0 PPM NORMAL 02-18-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3832 M 0 PPM DISPOSITION 03-27-09 6:51 P SCHEDULED EUTHANASIA 3837 M 0 PPM NORMAL 02-18-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3837 M 0 PPM DISPOSITION 03-24-09 7:40 P SCHEDULED EUTHANASIA 3843 M 0 PPM NORMAL 02-18-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3843 M 0 PPM DISPOSITION 03-25-09 7:46 P SCHEDULED EUTHANASIA 3764 M 1000 PPM NORMAL 02-18-09 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3764 M 1000 PPM NORMAL 02-25-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3764 M 1000 PPM DISPOSITION 03-27-09 10:14 P SCHEDULED EUTHANASIA 3769 M 1000 PPM NORMAL 02-18-09 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3769 M 1000 PPM DISPOSITION 03-26-09 7:56 P SCHEDULED EUTHANASIA 3772 M 1000 PPM NORMAL 02-18-09 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3772 M 1000 PPM DISPOSITION 03-24-09 7:39 P SCHEDULED EUTHANASIA 3773 M 1000 PPM NORMAL 02-18-09 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3773 M 1000 PPM DISPOSITION 03-27-09 6:52 P SCHEDULED EUTHANASIA 3781 M 1000 PPM NORMAL 02-18-09 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3781 M 1000 PPM DISPOSITION 03-26-09 7:56 P SCHEDULED EUTHANASIA 3800 M 1000 PPM NORMAL 02-18-09 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3800 M 1000 PPM DISPOSITION 03-25-09 7:44 P SCHEDULED EUTHANASIA 3800 M 1000 PPM BODY/INTEGUMENT 03-25-09 6:27 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:27 1 HAIR LOSS LEFT FORELIMB 3801 M 1000 PPM NORMAL 02-18-09 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3801 M 1000 PPM DISPOSITION 03-27-09 10:14 P SCHEDULED EUTHANASIA 3805 M 1000 PPM NORMAL 02-18-09 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3805 M 1000 PPM NORMAL 03-18-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3805 M 1000 PPM DISPOSITION 03-25-09 7:47 P SCHEDULED EUTHANASIA 3806 M 1000 PPM NORMAL 02-18-09 8:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3806 M 1000 PPM DISPOSITION 03-27-09 10:14 P SCHEDULED EUTHANASIA 3816 M 1000 PPM NORMAL 02-18-09 13:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3816 M 1000 PPM DISPOSITION 03-23-09 7:56 P SCHEDULED EUTHANASIA 3818 M 1000 PPM NORMAL 02-18-09 8:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3818 M 1000 PPM DISPOSITION 03-24-09 7:38 P SCHEDULED EUTHANASIA 3824 M 1000 PPM NORMAL 02-18-09 8:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3824 M 1000 PPM NORMAL 03-18-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3824 M 1000 PPM DISPOSITION 03-27-09 10:14 P SCHEDULED EUTHANASIA 3840 M 1000 PPM NORMAL 02-18-09 8:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3840 M 1000 PPM DISPOSITION 03-27-09 10:15 P SCHEDULED EUTHANASIA 3845 M 1000 PPM NORMAL 02-18-09 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3845 M 1000 PPM DISPOSITION 03-23-09 7:54 P SCHEDULED EUTHANASIA 3846 M 1000 PPM NORMAL 02-18-09 8:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3846 M 1000 PPM DISPOSITION 03-27-09 6:52 P SCHEDULED EUTHANASIA 3762 M 1500 PPM NORMAL 02-18-09 9:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3762 M 1500 PPM NORMAL 03-04-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3762 M 1500 PPM DISPOSITION 03-24-09 7:38 P SCHEDULED EUTHANASIA 3765 M 1500 PPM NORMAL 02-18-09 9:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3765 M 1500 PPM DISPOSITION 03-27-09 10:16 P SCHEDULED EUTHANASIA 3766 M 1500 PPM NORMAL 02-18-09 9:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3766 M 1500 PPM DISPOSITION 03-27-09 10:16 P SCHEDULED EUTHANASIA 3766 M 1500 PPM BODY/INTEGUMENT 03-11-09 6:50 1 HAIR LOSS RIGHT FORELIMB 03-11-09 6:50 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:07 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:07 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:35 2 HAIR LOSS RIGHT FORELIMB 03-25-09 6:35 2 HAIR LOSS LEFT FORELIMB 03-27-09 7:16 2 HAIR LOSS RIGHT FORELIMB 03-27-09 7:16 2 HAIR LOSS LEFT FORELIMB 3768 M 1500 PPM NORMAL 02-18-09 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3768 M 1500 PPM DISPOSITION 03-26-09 7:58 P SCHEDULED EUTHANASIA 3768 M 1500 PPM BODY/INTEGUMENT 03-11-09 6:51 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:08 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:08 1 HAIR LOSS VENTRAL THORACIC AREA 03-18-09 7:08 1 HAIR LOSS LEFT HINDLIMB 03-18-09 7:08 1 HAIR LOSS LEFT INGUINAL AREA 03-25-09 6:36 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:36 1 HAIR LOSS VENTRAL THORACIC AREA 3777 M 1500 PPM NORMAL 02-18-09 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3777 M 1500 PPM DISPOSITION 03-27-09 10:16 P SCHEDULED EUTHANASIA 3778 M 1500 PPM NORMAL 02-18-09 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3778 M 1500 PPM DISPOSITION 03-27-09 10:16 P SCHEDULED EUTHANASIA 3786 M 1500 PPM NORMAL 02-18-09 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3786 M 1500 PPM DISPOSITION 03-27-09 6:50 P SCHEDULED EUTHANASIA 3786 M 1500 PPM BODY/INTEGUMENT 03-11-09 6:52 1 HAIR LOSS RIGHT FORELIMB-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3786 M 1500 PPM BODY/INTEGUMENT 03-11-09 6:52 1 HAIR LOSS LEFT FORELIMB 03-11-09 6:52 2 HAIR LOSS VENTRAL THORACIC AREA 03-11-09 6:52 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:09 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:09 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:10 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:10 2 HAIR LOSS VENTRAL THORACIC AREA 03-18-09 7:10 1 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-25-09 6:37 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:37 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:38 1 HAIR LOSS VENTRAL ABDOMINAL AREA 03-25-09 6:38 1 HAIR LOSS VENTRAL THORACIC AREA 03-25-09 6:38 1 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-27-09 6:18 1 HAIR LOSS RIGHT FORELIMB 03-27-09 6:18 1 HAIR LOSS LEFT FORELIMB 03-27-09 6:18 1 HAIR LOSS VENTRAL ABDOMINAL AREA 03-27-09 6:18 1 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 3788 M 1500 PPM NORMAL 02-18-09 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3788 M 1500 PPM DISPOSITION 03-24-09 7:38 P SCHEDULED EUTHANASIA 3798 M 1500 PPM NORMAL 02-18-09 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3798 M 1500 PPM NORMAL 03-25-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3798 M 1500 PPM DISPOSITION 03-27-09 10:16 P SCHEDULED EUTHANASIA 3813 M 1500 PPM NORMAL 02-18-09 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3813 M 1500 PPM DISPOSITION 03-23-09 7:52 P SCHEDULED EUTHANASIA 3819 M 1500 PPM NORMAL 02-18-09 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3819 M 1500 PPM DISPOSITION 03-25-09 7:49 P SCHEDULED EUTHANASIA 3819 M 1500 PPM BODY/INTEGUMENT 03-11-09 6:54 1 HAIR LOSS RIGHT FORELIMB 03-11-09 6:54 2 HAIR LOSS LEFT FORELIMB 03-18-09 7:12 2 HAIR LOSS RIGHT FORELIMB 03-18-09 7:12 2 HAIR LOSS LEFT FORELIMB 03-25-09 6:39 3 HAIR LOSS RIGHT FORELIMB 03-25-09 6:39 3 HAIR LOSS LEFT FORELIMB 3825 M 1500 PPM NORMAL 02-18-09 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3825 M 1500 PPM DISPOSITION 03-27-09 6:53 P SCHEDULED EUTHANASIA 3833 M 1500 PPM NORMAL 02-18-09 13:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3833 M 1500 PPM NORMAL 02-25-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3833 M 1500 PPM DISPOSITION 03-23-09 7:58 P SCHEDULED EUTHANASIA 3841 M 1500 PPM NORMAL 02-18-09 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3841 M 1500 PPM DISPOSITION 03-26-09 7:57 P SCHEDULED EUTHANASIA 3842 M 1500 PPM NORMAL 02-18-09 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3842 M 1500 PPM DISPOSITION 03-25-09 7:47 P SCHEDULED EUTHANASIA 3842 M 1500 PPM EYES/EARS/NOSE 02-25-09 6:57 1 DRIED RED MATERIAL AROUND RIGHT EYE 03-04-09 7:18 1 DRIED RED MATERIAL AROUND RIGHT EYE 3760 M 2000 PPM NORMAL 02-18-09 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3760 M 2000 PPM DISPOSITION 03-25-09 7:46 P SCHEDULED EUTHANASIA 3760 M 2000 PPM BODY/INTEGUMENT 03-25-09 6:46 1 HAIR LOSS VENTRAL ABDOMINAL AREA 3770 M 2000 PPM NORMAL 02-18-09 13:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3770 M 2000 PPM NORMAL 02-25-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3770 M 2000 PPM DISPOSITION 03-19-09 15:44 P FOUND DEAD 3779 M 2000 PPM NORMAL 02-18-09 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3779 M 2000 PPM DISPOSITION 03-27-09 6:50 P SCHEDULED EUTHANASIA 3779 M 2000 PPM BODY/INTEGUMENT 03-27-09 6:19 1 HAIR LOSS RIGHT FORELIMB 03-27-09 6:19 1 HAIR LOSS LEFT FORELIMB 3779 M 2000 PPM EYES/EARS/NOSE 03-27-09 6:19 1 DRIED RED MATERIAL AROUND NOSE 3782 M 2000 PPM NORMAL 02-18-09 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3782 M 2000 PPM DISPOSITION 03-27-09 6:51 P SCHEDULED EUTHANASIA 3784 M 2000 PPM NORMAL 02-18-09 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3784 M 2000 PPM DISPOSITION 03-24-09 7:38 P SCHEDULED EUTHANASIA 3792 M 2000 PPM NORMAL 02-18-09 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3792 M 2000 PPM DISPOSITION 03-27-09 10:18 P SCHEDULED EUTHANASIA 3792 M 2000 PPM BODY/INTEGUMENT 03-11-09 7:07 1 HAIR LOSS RIGHT FORELIMB 03-11-09 7:07 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:26 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:49 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:49 1 HAIR LOSS LEFT FORELIMB 03-27-09 7:20 1 HAIR LOSS RIGHT FORELIMB 3793 M 2000 PPM NORMAL 02-18-09 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3793 M 2000 PPM DISPOSITION 03-26-09 7:59 P SCHEDULED EUTHANASIA 3793 M 2000 PPM BODY/INTEGUMENT 03-11-09 7:08 1 HAIR LOSS RIGHT FORELIMB 03-11-09 7:08 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:26 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:26 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:50 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:50 1 HAIR LOSS LEFT FORELIMB 03-26-09 7:36 1 HAIR LOSS LEFT FORELIMB 03-26-09 7:36 1 HAIR LOSS RIGHT FORELIMB 3794 M 2000 PPM NORMAL 02-18-09 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3794 M 2000 PPM DISPOSITION 03-24-09 7:39 P SCHEDULED EUTHANASIA-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3794 M 2000 PPM EYES/EARS/NOSE 03-24-09 7:06 1 DRIED RED MATERIAL AROUND NOSE 3799 M 2000 PPM NORMAL 02-18-09 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3799 M 2000 PPM DISPOSITION 03-27-09 10:18 P SCHEDULED EUTHANASIA 3799 M 2000 PPM BODY/INTEGUMENT 02-25-09 7:07 1 HAIR LOSS RIGHT FORELIMB 02-25-09 7:07 1 HAIR LOSS LEFT FORELIMB 03-11-09 7:09 1 HAIR LOSS RIGHT FORELIMB 03-11-09 7:09 2 HAIR LOSS LEFT FORELIMB 03-18-09 7:27 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:27 2 HAIR LOSS LEFT FORELIMB 03-25-09 6:50 1 HAIR LOSS LEFT FORELIMB 03-27-09 7:21 1 HAIR LOSS RIGHT FORELIMB 03-27-09 7:21 1 HAIR LOSS LEFT FORELIMB 3809 M 2000 PPM NORMAL 02-18-09 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3809 M 2000 PPM DISPOSITION 03-27-09 10:18 P SCHEDULED EUTHANASIA 3809 M 2000 PPM BODY/INTEGUMENT 03-11-09 7:09 1 HAIR LOSS RIGHT FORELIMB 03-11-09 7:10 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:28 2 HAIR LOSS RIGHT FORELIMB 03-18-09 7:28 2 HAIR LOSS LEFT FORELIMB 03-25-09 6:51 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:51 1 HAIR LOSS LEFT FORELIMB 03-27-09 7:21 1 HAIR LOSS LEFT FORELIMB 3809 M 2000 PPM EYES/EARS/NOSE 03-27-09 7:21 1 DRIED RED MATERIAL AROUND NOSE 3812 M 2000 PPM NORMAL 02-18-09 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3812 M 2000 PPM NORMAL 03-18-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3812 M 2000 PPM DISPOSITION 03-27-09 10:18 P SCHEDULED EUTHANASIA 3812 M 2000 PPM EYES/EARS/NOSE 03-27-09 7:22 1 DRIED RED MATERIAL AROUND NOSE 3815 M 2000 PPM NORMAL 02-18-09 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3815 M 2000 PPM DISPOSITION 03-27-09 10:18 P SCHEDULED EUTHANASIA 3815 M 2000 PPM EYES/EARS/NOSE 03-18-09 7:29 1 DRIED RED MATERIAL AROUND RIGHT EYE 03-18-09 7:29 1 DRIED RED MATERIAL AROUND LEFT EYE 03-18-09 7:29 1 DRIED RED MATERIAL AROUND NOSE 03-27-09 7:23 1 DRIED RED MATERIAL AROUND RIGHT EYE 3815 M 2000 PPM ORAL/DENTAL 03-18-09 7:31 P UPPER INCISORS MALALIGNED 3820 M 2000 PPM NORMAL 02-18-09 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3820 M 2000 PPM DISPOSITION 03-25-09 7:49 P SCHEDULED EUTHANASIA 3820 M 2000 PPM BODY/INTEGUMENT 03-11-09 7:11 1 HAIR LOSS RIGHT FORELIMB 03-11-09 7:11 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:32 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:32 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:52 2 HAIR LOSS RIGHT FORELIMB 03-25-09 6:52 2 HAIR LOSS LEFT FORELIMB 3821 M 2000 PPM NORMAL 02-18-09 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3821 M 2000 PPM DISPOSITION 03-26-09 7:59 P SCHEDULED EUTHANASIA-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3821 M 2000 PPM BODY/INTEGUMENT 03-11-09 7:12 1 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:32 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:32 1 HAIR LOSS RIGHT INGUINAL AREA 03-18-09 7:32 1 HAIR LOSS LEFT INGUINAL AREA 03-18-09 7:32 2 HAIR LOSS RIGHT HINDLIMB 03-18-09 7:32 2 HAIR LOSS LEFT HINDLIMB 03-25-09 6:52 2 HAIR LOSS RIGHT HINDLIMB 03-25-09 6:52 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-25-09 6:53 2 HAIR LOSS UROGENITAL AREA 03-25-09 6:53 2 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-26-09 7:33 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-26-09 7:34 2 HAIR LOSS RIGHT HINDLIMB 3838 M 2000 PPM NORMAL 02-18-09 13:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3838 M 2000 PPM DISPOSITION 03-23-09 7:53 P SCHEDULED EUTHANASIA 3838 M 2000 PPM BODY/INTEGUMENT 03-11-09 7:13 2 HAIR LOSS VENTRAL ABDOMINAL AREA 3763 M 2500 PPM NORMAL 02-18-09 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3763 M 2500 PPM DISPOSITION 03-24-09 7:40 P SCHEDULED EUTHANASIA 3767 M 2500 PPM NORMAL 02-18-09 13:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3767 M 2500 PPM NORMAL 03-11-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3767 M 2500 PPM DISPOSITION 03-23-09 7:57 P SCHEDULED EUTHANASIA 3771 M 2500 PPM NORMAL 02-18-09 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3771 M 2500 PPM DISPOSITION 03-25-09 7:47 P SCHEDULED EUTHANASIA 3771 M 2500 PPM BODY/INTEGUMENT 03-11-09 7:26 1 HAIR LOSS RIGHT FORELIMB 03-11-09 7:26 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:46 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:46 1 HAIR LOSS LEFT FORELIMB 03-25-09 7:00 1 HAIR LOSS RIGHT FORELIMB 03-25-09 7:00 1 HAIR LOSS LEFT FORELIMB 3775 M 2500 PPM NORMAL 02-18-09 9:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3775 M 2500 PPM DISPOSITION 03-27-09 6:51 P SCHEDULED EUTHANASIA 3775 M 2500 PPM BODY/INTEGUMENT 03-25-09 7:00 1 HAIR LOSS RIGHT FORELIMB 03-25-09 7:00 1 HAIR LOSS LEFT FORELIMB 03-27-09 6:21 1 HAIR LOSS RIGHT FORELIMB 03-27-09 6:21 1 HAIR LOSS LEFT FORELIMB 3783 M 2500 PPM NORMAL 02-18-09 9:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3783 M 2500 PPM NORMAL 03-25-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3783 M 2500 PPM DISPOSITION 03-27-09 10:19 P SCHEDULED EUTHANASIA 3785 M 2500 PPM NORMAL 02-18-09 9:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3785 M 2500 PPM DISPOSITION 03-27-09 10:19 P SCHEDULED EUTHANASIA 3795 M 2500 PPM NORMAL 02-18-09 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3795 M 2500 PPM DISPOSITION 03-26-09 7:55 P SCHEDULED EUTHANASIA 3795 M 2500 PPM BODY/INTEGUMENT 03-11-09 7:28 1 HAIR LOSS DORSAL HEAD 3804 M 2500 PPM NORMAL 02-18-09 9:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3804 M 2500 PPM DISPOSITION 03-25-09 7:49 P SCHEDULED EUTHANASIA 3807 M 2500 PPM NORMAL 02-18-09 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 21 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3807 M 2500 PPM NORMAL 03-25-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3807 M 2500 PPM DISPOSITION 03-27-09 10:20 P SCHEDULED EUTHANASIA 3807 M 2500 PPM BODY/INTEGUMENT 03-11-09 7:29 1 HAIR LOSS RIGHT FORELIMB 03-11-09 7:29 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:48 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:48 1 HAIR LOSS LEFT FORELIMB 03-27-09 7:28 1 HAIR LOSS RIGHT FORELIMB 03-27-09 7:28 1 HAIR LOSS LEFT FORELIMB 3810 M 2500 PPM NORMAL 02-18-09 9:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3810 M 2500 PPM DISPOSITION 03-27-09 10:20 P SCHEDULED EUTHANASIA 3814 M 2500 PPM NORMAL 02-18-09 9:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3814 M 2500 PPM DISPOSITION 03-24-09 7:39 P SCHEDULED EUTHANASIA 3817 M 2500 PPM NORMAL 02-18-09 9:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 22 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3817 M 2500 PPM NORMAL 03-26-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3817 M 2500 PPM DISPOSITION 03-26-09 7:58 P SCHEDULED EUTHANASIA 3822 M 2500 PPM NORMAL 02-18-09 9:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3822 M 2500 PPM DISPOSITION 03-27-09 6:53 P SCHEDULED EUTHANASIA 3822 M 2500 PPM EYES/EARS/NOSE 03-25-09 7:04 1 DRIED RED MATERIAL AROUND NOSE 3831 M 2500 PPM NORMAL 02-18-09 9:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3831 M 2500 PPM DISPOSITION 03-27-09 10:20 P SCHEDULED EUTHANASIA 3831 M 2500 PPM EYES/EARS/NOSE 03-25-09 7:04 1 DRIED RED MATERIAL AROUND NOSE 3839 M 2500 PPM NORMAL 02-18-09 13:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3839 M 2500 PPM DISPOSITION 03-23-09 7:52 P SCHEDULED EUTHANASIA 3677 F 0 PPM NORMAL 02-18-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 23 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3677 F 0 PPM NORMAL 03-18-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3677 F 0 PPM DISPOSITION 03-27-09 6:52 P SCHEDULED EUTHANASIA 3686 F 0 PPM NORMAL 02-18-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3686 F 0 PPM DISPOSITION 03-26-09 7:57 P SCHEDULED EUTHANASIA 3691 F 0 PPM NORMAL 02-18-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3691 F 0 PPM DISPOSITION 03-27-09 10:13 P SCHEDULED EUTHANASIA 3691 F 0 PPM BODY/INTEGUMENT 03-18-09 6:43 1 HAIR LOSS RIGHT FORELIMB 03-18-09 6:43 1 HAIR LOSS LEFT FORELIMB 03-27-09 7:09 1 HAIR LOSS RIGHT FORELIMB 03-27-09 7:09 1 HAIR LOSS LEFT FORELIMB 3693 F 0 PPM NORMAL 02-18-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 24 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3693 F 0 PPM DISPOSITION 03-27-09 10:13 P SCHEDULED EUTHANASIA 3694 F 0 PPM NORMAL 02-18-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3694 F 0 PPM DISPOSITION 03-26-09 7:58 P SCHEDULED EUTHANASIA 3696 F 0 PPM NORMAL 02-18-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3696 F 0 PPM DISPOSITION 03-27-09 6:51 P SCHEDULED EUTHANASIA 3704 F 0 PPM NORMAL 02-18-09 13:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3704 F 0 PPM DISPOSITION 03-23-09 7:54 P SCHEDULED EUTHANASIA 3714 F 0 PPM NORMAL 02-18-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3714 F 0 PPM DISPOSITION 03-25-09 7:47 P SCHEDULED EUTHANASIA-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 25 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3714 F 0 PPM BODY/INTEGUMENT 03-18-09 6:45 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:22 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:22 1 HAIR LOSS LEFT FORELIMB 3714 F 0 PPM EYES/EARS/NOSE 03-25-09 6:23 1 DRIED RED MATERIAL AROUND NOSE 3719 F 0 PPM NORMAL 02-18-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3719 F 0 PPM DISPOSITION 03-27-09 10:13 P SCHEDULED EUTHANASIA 3723 F 0 PPM NORMAL 02-18-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3723 F 0 PPM DISPOSITION 03-27-09 10:13 P SCHEDULED EUTHANASIA 3725 F 0 PPM NORMAL 02-18-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3725 F 0 PPM DISPOSITION 03-24-09 7:38 P SCHEDULED EUTHANASIA 3733 F 0 PPM NORMAL 02-18-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 26 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3733 F 0 PPM NORMAL 03-04-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3733 F 0 PPM DISPOSITION 03-27-09 10:13 P SCHEDULED EUTHANASIA 3738 F 0 PPM NORMAL 02-18-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3738 F 0 PPM DISPOSITION 03-25-09 7:48 P SCHEDULED EUTHANASIA 3738 F 0 PPM BODY/INTEGUMENT 03-11-09 6:32 1 HAIR LOSS RIGHT FORELIMB 03-11-09 6:32 1 HAIR LOSS LEFT FORELIMB 03-18-09 6:48 1 HAIR LOSS RIGHT FORELIMB 03-18-09 6:48 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:24 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:24 1 HAIR LOSS LEFT FORELIMB 3744 F 0 PPM NORMAL 02-18-09 13:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3744 F 0 PPM DISPOSITION 03-23-09 7:53 P SCHEDULED EUTHANASIA 3757 F 0 PPM NORMAL 02-18-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 27 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3757 F 0 PPM DISPOSITION 03-24-09 7:37 P SCHEDULED EUTHANASIA 3672 F 1000 PPM NORMAL 02-18-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3672 F 1000 PPM DISPOSITION 03-27-09 10:15 P SCHEDULED EUTHANASIA 3675 F 1000 PPM NORMAL 02-18-09 13:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3675 F 1000 PPM DISPOSITION 03-23-09 7:57 P SCHEDULED EUTHANASIA 3683 F 1000 PPM NORMAL 02-18-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3683 F 1000 PPM DISPOSITION 03-27-09 10:15 P SCHEDULED EUTHANASIA 3690 F 1000 PPM NORMAL 02-18-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 28 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3690 F 1000 PPM NORMAL 03-25-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3690 F 1000 PPM DISPOSITION 03-27-09 10:15 P SCHEDULED EUTHANASIA 3695 F 1000 PPM NORMAL 02-18-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3695 F 1000 PPM DISPOSITION 03-27-09 6:53 P SCHEDULED EUTHANASIA 3697 F 1000 PPM NORMAL 02-18-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3697 F 1000 PPM DISPOSITION 03-27-09 10:15 P SCHEDULED EUTHANASIA 3700 F 1000 PPM NORMAL 02-18-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3700 F 1000 PPM DISPOSITION 03-24-09 7:40 P SCHEDULED EUTHANASIA 3702 F 1000 PPM NORMAL 02-18-09 13:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3702 F 1000 PPM DISPOSITION 03-23-09 7:54 P SCHEDULED EUTHANASIA-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 29 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3702 F 1000 PPM BODY/INTEGUMENT 02-25-09 6:34 2 HAIR LOSS RIGHT FORELIMB 02-25-09 6:34 2 HAIR LOSS LEFT FORELIMB 03-11-09 6:45 1 HAIR LOSS RIGHT FORELIMB 03-11-09 6:45 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:01 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:01 1 HAIR LOSS LEFT FORELIMB 03-23-09 7:13 1 HAIR LOSS RIGHT FORELIMB 03-23-09 7:13 1 HAIR LOSS LEFT FORELIMB 3706 F 1000 PPM NORMAL 02-18-09 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3706 F 1000 PPM DISPOSITION 03-27-09 10:15 P SCHEDULED EUTHANASIA 3712 F 1000 PPM NORMAL 02-18-09 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3712 F 1000 PPM DISPOSITION 03-27-09 6:53 P SCHEDULED EUTHANASIA 3713 F 1000 PPM NORMAL 02-18-09 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 30 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3713 F 1000 PPM DISPOSITION 03-26-09 7:56 P SCHEDULED EUTHANASIA 3713 F 1000 PPM BODY/INTEGUMENT 03-11-09 6:46 1 HAIR LOSS DORSAL HEAD 03-26-09 7:27 1 HAIR LOSS DORSAL HEAD 3718 F 1000 PPM NORMAL 02-18-09 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3718 F 1000 PPM DISPOSITION 03-25-09 7:48 P SCHEDULED EUTHANASIA 3720 F 1000 PPM NORMAL 02-18-09 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3720 F 1000 PPM DISPOSITION 03-25-09 7:48 P SCHEDULED EUTHANASIA 3743 F 1000 PPM NORMAL 02-18-09 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3743 F 1000 PPM DISPOSITION 03-26-09 7:57 P SCHEDULED EUTHANASIA 3743 F 1000 PPM BODY/INTEGUMENT 02-25-09 6:36 1 HAIR LOSS RIGHT FORELIMB 02-25-09 6:36 1 HAIR LOSS LEFT FORELIMB 03-11-09 6:48 1 HAIR LOSS RIGHT FORELIMB 03-11-09 6:48 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:03 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:03 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:34 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:34 1 HAIR LOSS LEFT FORELIMB 03-26-09 7:31 1 HAIR LOSS RIGHT FORELIMB-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 31 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3743 F 1000 PPM BODY/INTEGUMENT 03-26-09 7:31 1 HAIR LOSS LEFT FORELIMB 3747 F 1000 PPM NORMAL 02-18-09 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3747 F 1000 PPM DISPOSITION 03-24-09 7:40 P SCHEDULED EUTHANASIA 3674 F 1500 PPM NORMAL 02-18-09 13:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3674 F 1500 PPM DISPOSITION 03-23-09 7:55 P SCHEDULED EUTHANASIA 3674 F 1500 PPM EYES/EARS/NOSE 03-18-09 7:16 1 DRIED RED MATERIAL AROUND LEFT EYE 3684 F 1500 PPM NORMAL 02-18-09 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3684 F 1500 PPM DISPOSITION 03-27-09 10:17 P SCHEDULED EUTHANASIA 3684 F 1500 PPM BODY/INTEGUMENT 03-11-09 6:58 1 HAIR LOSS RIGHT FORELIMB 03-11-09 6:58 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:17 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:17 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:41 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:41 1 HAIR LOSS LEFT FORELIMB 03-27-09 7:17 1 HAIR LOSS RIGHT FORELIMB 03-27-09 7:17 1 HAIR LOSS LEFT FORELIMB 3701 F 1500 PPM NORMAL 02-18-09 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 32 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3701 F 1500 PPM NORMAL 03-04-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3701 F 1500 PPM DISPOSITION 03-24-09 7:40 P SCHEDULED EUTHANASIA 3708 F 1500 PPM NORMAL 02-18-09 9:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3708 F 1500 PPM DISPOSITION 03-25-09 7:48 P SCHEDULED EUTHANASIA 3708 F 1500 PPM BODY/INTEGUMENT 03-18-09 7:18 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:18 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:41 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:41 1 HAIR LOSS LEFT FORELIMB 3711 F 1500 PPM NORMAL 02-18-09 9:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3711 F 1500 PPM DISPOSITION 03-27-09 6:51 P SCHEDULED EUTHANASIA 3722 F 1500 PPM NORMAL 02-18-09 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 33 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3722 F 1500 PPM DISPOSITION 03-26-09 7:57 P SCHEDULED EUTHANASIA 3724 F 1500 PPM NORMAL 03-04-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3724 F 1500 PPM DISPOSITION 03-27-09 10:17 P SCHEDULED EUTHANASIA 3724 F 1500 PPM BODY/INTEGUMENT 02-18-09 9:02 1 HAIR LOSS RIGHT FORELIMB 02-18-09 9:02 1 HAIR LOSS LEFT FORELIMB 02-25-09 6:47 1 HAIR LOSS RIGHT FORELIMB 02-25-09 6:47 1 HAIR LOSS LEFT FORELIMB 03-11-09 7:00 1 HAIR LOSS RIGHT FORELIMB 03-11-09 7:00 1 HAIR LOSS LEFT FORELIMB 03-11-09 7:00 1 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:19 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:19 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:19 1 HAIR LOSS VENTRAL ABDOMINAL AREA 03-25-09 6:42 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:42 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:42 1 HAIR LOSS LEFT HINDLIMB 03-27-09 7:18 1 HAIR LOSS RIGHT FORELIMB 03-27-09 7:18 2 HAIR LOSS LEFT FORELIMB 03-27-09 7:18 1 HAIR LOSS VENTRAL ABDOMINAL AREA 03-27-09 7:18 2 HAIR LOSS LEFT HINDLIMB 3726 F 1500 PPM NORMAL 02-18-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3726 F 1500 PPM DISPOSITION 03-26-09 7:55 P SCHEDULED EUTHANASIA 3727 F 1500 PPM NORMAL 02-18-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 34 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3727 F 1500 PPM NORMAL 02-25-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3727 F 1500 PPM DISPOSITION 03-27-09 6:53 P SCHEDULED EUTHANASIA 3728 F 1500 PPM NORMAL 02-18-09 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3728 F 1500 PPM DISPOSITION 03-27-09 10:17 P SCHEDULED EUTHANASIA 3729 F 1500 PPM NORMAL 02-18-09 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3729 F 1500 PPM DISPOSITION 03-27-09 10:17 P SCHEDULED EUTHANASIA 3731 F 1500 PPM NORMAL 02-18-09 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3731 F 1500 PPM DISPOSITION 03-25-09 7:48 P SCHEDULED EUTHANASIA 3731 F 1500 PPM BODY/INTEGUMENT 03-18-09 7:21 1 HAIR LOSS RIGHT FORELIMB-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 35 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3731 F 1500 PPM BODY/INTEGUMENT 03-18-09 7:21 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:45 1 HAIR LOSS RIGHT FORELIMB 3734 F 1500 PPM NORMAL 02-18-09 13:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3734 F 1500 PPM DISPOSITION 03-23-09 7:55 P SCHEDULED EUTHANASIA 3748 F 1500 PPM NORMAL 02-18-09 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3748 F 1500 PPM DISPOSITION 03-27-09 10:17 P SCHEDULED EUTHANASIA 3756 F 1500 PPM NORMAL 02-18-09 9:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3756 F 1500 PPM DISPOSITION 03-24-09 7:37 P SCHEDULED EUTHANASIA 3756 F 1500 PPM BODY/INTEGUMENT 03-11-09 7:03 1 HAIR LOSS VENTRAL ABDOMINAL AREA 3676 F 2000 PPM NORMAL 02-18-09 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 36 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3676 F 2000 PPM DISPOSITION 03-27-09 6:50 P SCHEDULED EUTHANASIA 3676 F 2000 PPM BODY/INTEGUMENT 03-11-09 7:14 1 HAIR LOSS VENTRAL ABDOMINAL AREA 03-11-09 7:14 1 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-11-09 7:14 1 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 03-18-09 7:35 1 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:35 1 HAIR LOSS VENTRAL THORACIC AREA 03-18-09 7:35 1 HAIR LOSS LEFT HINDLIMB 3678 F 2000 PPM NORMAL 02-18-09 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3678 F 2000 PPM DISPOSITION 03-24-09 7:38 P SCHEDULED EUTHANASIA 3678 F 2000 PPM BODY/INTEGUMENT 03-11-09 7:15 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:35 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:35 1 HAIR LOSS LEFT FORELIMB 03-24-09 7:04 2 HAIR LOSS RIGHT FORELIMB 03-24-09 7:04 2 HAIR LOSS LEFT FORELIMB 3682 F 2000 PPM NORMAL 02-18-09 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3682 F 2000 PPM DISPOSITION 03-27-09 10:19 P SCHEDULED EUTHANASIA 3682 F 2000 PPM BODY/INTEGUMENT 03-11-09 7:15 1 HAIR LOSS LEFT FORELIMB 3705 F 2000 PPM NORMAL 02-18-09 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 37 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3705 F 2000 PPM NORMAL 03-25-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3705 F 2000 PPM DISPOSITION 03-27-09 10:19 P SCHEDULED EUTHANASIA 3709 F 2000 PPM NORMAL 02-18-09 9:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3709 F 2000 PPM DISPOSITION 03-26-09 7:59 P SCHEDULED EUTHANASIA 3709 F 2000 PPM BODY/INTEGUMENT 03-11-09 7:17 2 HAIR LOSS VENTRAL THORACIC AREA 03-11-09 7:17 3 HAIR LOSS VENTRAL ABDOMINAL AREA 03-11-09 7:18 2 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-11-09 7:18 2 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 03-11-09 7:18 3 HAIR LOSS RIGHT HINDLIMB 03-11-09 7:18 3 HAIR LOSS LEFT HINDLIMB 03-11-09 7:18 1 HAIR LOSS RIGHT INGUINAL AREA 03-11-09 7:18 1 HAIR LOSS LEFT INGUINAL AREA 03-11-09 7:18 1 HAIR LOSS RIGHT FORELIMB 03-18-09 7:37 3 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:37 3 HAIR LOSS VENTRAL THORACIC AREA 03-18-09 7:37 2 HAIR LOSS RIGHT FORELIMB 03-18-09 7:37 2 HAIR LOSS LEFT FORELIMB 03-18-09 7:37 3 HAIR LOSS RIGHT HINDLIMB 03-18-09 7:37 3 HAIR LOSS LEFT HINDLIMB 03-18-09 7:37 3 HAIR LOSS RIGHT INGUINAL AREA 03-18-09 7:37 3 HAIR LOSS LEFT INGUINAL AREA 03-18-09 7:37 3 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-18-09 7:37 3 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 03-18-09 7:38 2 HAIR LOSS RUMP 03-18-09 7:38 2 HAIR LOSS RIGHT AXILLARY AREA 03-18-09 7:38 2 HAIR LOSS LEFT AXILLARY AREA-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 38 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3709 F 2000 PPM BODY/INTEGUMENT 03-18-09 7:39 2 HAIR LOSS UROGENITAL AREA 03-25-09 6:54 2 HAIR LOSS RIGHT FORELIMB 03-25-09 6:55 2 HAIR LOSS LEFT FORELIMB 03-25-09 6:55 3 HAIR LOSS VENTRAL ABDOMINAL AREA 03-25-09 6:55 3 HAIR LOSS VENTRAL THORACIC AREA 03-25-09 6:55 1 HAIR LOSS RUMP 03-25-09 6:55 3 HAIR LOSS RIGHT HINDLIMB 03-25-09 6:55 3 HAIR LOSS LEFT HINDLIMB 03-25-09 6:55 3 HAIR LOSS RIGHT INGUINAL AREA 03-25-09 6:55 3 HAIR LOSS LEFT INGUINAL AREA 03-25-09 6:55 2 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-25-09 6:55 2 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 03-25-09 6:56 2 HAIR LOSS RIGHT AXILLARY AREA 03-25-09 6:56 2 HAIR LOSS LEFT AXILLARY AREA 03-25-09 6:56 3 HAIR LOSS UROGENITAL AREA 03-26-09 7:35 3 HAIR LOSS RIGHT HINDLIMB 03-26-09 7:35 3 HAIR LOSS LEFT HINDLIMB 03-26-09 7:35 3 HAIR LOSS VENTRAL ABDOMINAL AREA 03-26-09 7:35 3 HAIR LOSS VENTRAL THORACIC AREA 03-26-09 7:35 2 HAIR LOSS RIGHT FORELIMB 03-26-09 7:35 2 HAIR LOSS LEFT FORELIMB 03-26-09 7:35 2 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 03-26-09 7:36 1 HAIR LOSS RUMP 3710 F 2000 PPM NORMAL 02-18-09 9:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 39 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3710 F 2000 PPM NORMAL 03-27-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3710 F 2000 PPM DISPOSITION 03-27-09 10:19 P SCHEDULED EUTHANASIA 3716 F 2000 PPM NORMAL 02-18-09 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3716 F 2000 PPM DISPOSITION 03-24-09 7:40 P SCHEDULED EUTHANASIA 3732 F 2000 PPM NORMAL 02-18-09 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3732 F 2000 PPM DISPOSITION 03-23-09 7:58 P SCHEDULED EUTHANASIA 3739 F 2000 PPM NORMAL 02-18-09 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3739 F 2000 PPM DISPOSITION 03-25-09 7:46 P SCHEDULED EUTHANASIA 3739 F 2000 PPM BODY/INTEGUMENT 03-11-09 7:20 1 HAIR LOSS RIGHT FORELIMB 03-11-09 7:20 1 HAIR LOSS LEFT FORELIMB 03-11-09 7:20 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-11-09 7:20 2 HAIR LOSS LEFT HINDLIMB 03-18-09 7:41 2 HAIR LOSS RIGHT FORELIMB 03-18-09 7:41 2 HAIR LOSS LEFT FORELIMB 03-18-09 7:41 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:41 2 HAIR LOSS VENTRAL THORACIC AREA 03-18-09 7:41 2 HAIR LOSS LEFT HINDLIMB-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 40 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3739 F 2000 PPM BODY/INTEGUMENT 03-18-09 7:41 1 HAIR LOSS RIGHT HINDLIMB 03-18-09 7:41 2 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-25-09 6:56 3 HAIR LOSS LEFT HINDLIMB 03-25-09 6:57 1 HAIR LOSS RIGHT HINDLIMB 03-25-09 6:57 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-25-09 6:57 1 HAIR LOSS RIGHT FORELIMB 03-25-09 6:57 1 HAIR LOSS LEFT FORELIMB 03-25-09 6:57 2 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-25-09 6:57 2 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 03-25-09 6:57 1 HAIR LOSS VENTRAL THORACIC AREA 3740 F 2000 PPM NORMAL 02-18-09 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3740 F 2000 PPM DISPOSITION 03-27-09 10:19 P SCHEDULED EUTHANASIA 3745 F 2000 PPM NORMAL 02-18-09 13:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3745 F 2000 PPM DISPOSITION 03-23-09 7:55 P SCHEDULED EUTHANASIA 3746 F 2000 PPM NORMAL 02-18-09 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 41 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3746 F 2000 PPM NORMAL 03-18-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3746 F 2000 PPM DISPOSITION 03-25-09 7:48 P SCHEDULED EUTHANASIA 3749 F 2000 PPM NORMAL 02-18-09 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3749 F 2000 PPM DISPOSITION 03-27-09 10:19 P SCHEDULED EUTHANASIA 3749 F 2000 PPM BODY/INTEGUMENT 03-11-09 7:22 2 HAIR LOSS RIGHT FORELIMB 03-11-09 7:22 2 HAIR LOSS LEFT FORELIMB 03-18-09 7:43 2 HAIR LOSS RIGHT FORELIMB 03-18-09 7:43 2 HAIR LOSS LEFT FORELIMB 03-25-09 6:58 2 HAIR LOSS RIGHT FORELIMB 03-25-09 6:58 2 HAIR LOSS LEFT FORELIMB 03-27-09 7:25 2 HAIR LOSS RIGHT FORELIMB 03-27-09 7:25 2 HAIR LOSS LEFT FORELIMB 3751 F 2000 PPM NORMAL 02-18-09 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3751 F 2000 PPM DISPOSITION 03-26-09 7:55 P SCHEDULED EUTHANASIA 3751 F 2000 PPM BODY/INTEGUMENT 03-18-09 7:43 1 HAIR LOSS VENTRAL ABDOMINAL AREA 3754 F 2000 PPM NORMAL 02-18-09 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3754 F 2000 PPM DISPOSITION 03-27-09 6:52 P SCHEDULED EUTHANASIA 3754 F 2000 PPM BODY/INTEGUMENT 02-25-09 7:03 1 HAIR LOSS LEFT FORELIMB 03-11-09 7:23 2 HAIR LOSS RIGHT FORELIMB 03-11-09 7:23 2 HAIR LOSS LEFT FORELIMB-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 42 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3754 F 2000 PPM BODY/INTEGUMENT 03-11-09 7:23 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-11-09 7:23 1 HAIR LOSS RIGHT HINDLIMB 03-18-09 7:44 2 HAIR LOSS RIGHT FORELIMB 03-18-09 7:44 2 HAIR LOSS LEFT FORELIMB 03-18-09 7:44 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:44 1 HAIR LOSS RIGHT INGUINAL AREA 03-18-09 7:44 1 HAIR LOSS LEFT INGUINAL AREA 03-25-09 6:59 2 HAIR LOSS RIGHT FORELIMB 03-25-09 6:59 2 HAIR LOSS LEFT FORELIMB 03-25-09 6:59 2 HAIR LOSS RIGHT HINDLIMB 03-25-09 6:59 1 HAIR LOSS LEFT HINDLIMB 03-25-09 6:59 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-27-09 6:23 2 HAIR LOSS RIGHT FORELIMB 03-27-09 6:23 2 HAIR LOSS LEFT FORELIMB 03-27-09 6:23 1 HAIR LOSS LEFT HINDLIMB 03-27-09 6:23 2 HAIR LOSS RIGHT HINDLIMB 03-27-09 6:23 2 HAIR LOSS VENTRAL ABDOMINAL AREA 3673 F 2500 PPM NORMAL 02-18-09 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3673 F 2500 PPM DISPOSITION 03-25-09 7:47 P SCHEDULED EUTHANASIA 3679 F 2500 PPM NORMAL 02-18-09 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 43 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3679 F 2500 PPM DISPOSITION 03-24-09 7:40 P SCHEDULED EUTHANASIA 3679 F 2500 PPM EYES/EARS/NOSE 03-24-09 7:00 1 DRIED RED MATERIAL AROUND NOSE 3680 F 2500 PPM NORMAL 02-18-09 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3680 F 2500 PPM DISPOSITION 03-26-09 7:56 P SCHEDULED EUTHANASIA 3680 F 2500 PPM BODY/INTEGUMENT 03-11-09 7:34 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-11-09 7:34 1 HAIR LOSS VENTRAL THORACIC AREA 03-11-09 7:34 1 HAIR LOSS RIGHT HINDLIMB 03-11-09 7:34 2 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 03-18-09 7:53 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:53 2 HAIR LOSS VENTRAL THORACIC AREA 03-18-09 7:53 1 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-18-09 7:53 2 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 03-18-09 7:53 2 HAIR LOSS LEFT HINDLIMB 03-25-09 7:05 3 HAIR LOSS VENTRAL ABDOMINAL AREA 03-25-09 7:05 2 HAIR LOSS VENTRAL THORACIC AREA 03-25-09 7:05 1 HAIR LOSS RIGHT HINDLIMB 03-25-09 7:05 1 HAIR LOSS LEFT HINDLIMB 03-25-09 7:05 1 HAIR LOSS RIGHT INGUINAL AREA 03-25-09 7:05 1 HAIR LOSS LEFT INGUINAL AREA 03-25-09 7:05 1 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-25-09 7:05 1 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 03-26-09 7:24 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-26-09 7:24 2 HAIR LOSS VENTRAL THORACIC AREA 03-26-09 7:24 1 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-26-09 7:24 2 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 03-26-09 7:26 1 HAIR LOSS RIGHT HINDLIMB 03-26-09 7:26 1 HAIR LOSS LEFT HINDLIMB-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 44 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3680 F 2500 PPM BODY/INTEGUMENT 03-26-09 7:26 1 HAIR LOSS RIGHT INGUINAL AREA 03-26-09 7:26 1 HAIR LOSS LEFT INGUINAL AREA 3685 F 2500 PPM NORMAL 02-18-09 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3685 F 2500 PPM DISPOSITION 03-27-09 6:54 P SCHEDULED EUTHANASIA 3685 F 2500 PPM BODY/INTEGUMENT 03-11-09 7:35 3 HAIR LOSS VENTRAL ABDOMINAL AREA 03-11-09 7:35 1 HAIR LOSS LEFT INGUINAL AREA 03-18-09 7:54 3 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:54 2 HAIR LOSS RIGHT INGUINAL AREA 03-18-09 7:54 2 HAIR LOSS LEFT INGUINAL AREA 03-25-09 7:06 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-25-09 7:06 1 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-27-09 6:27 2 HAIR LOSS VENTRAL ABDOMINAL AREA 3688 F 2500 PPM NORMAL 02-18-09 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3688 F 2500 PPM DISPOSITION 03-27-09 10:20 P SCHEDULED EUTHANASIA 3688 F 2500 PPM BODY/INTEGUMENT 03-11-09 7:35 2 HAIR LOSS RIGHT HINDLIMB 03-11-09 7:36 2 HAIR LOSS LEFT HINDLIMB 03-11-09 7:36 1 HAIR LOSS VENTRAL ABDOMINAL AREA 03-11-09 7:36 1 HAIR LOSS RIGHT INGUINAL AREA 03-18-09 7:54 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:55 1 HAIR LOSS VENTRAL THORACIC AREA 03-18-09 7:55 2 HAIR LOSS RIGHT HINDLIMB 03-18-09 7:55 1 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-18-09 7:55 1 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 03-18-09 7:55 1 HAIR LOSS LEFT HINDLIMB 03-25-09 7:06 2 HAIR LOSS VENTRAL ABDOMINAL AREA-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 45 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3688 F 2500 PPM BODY/INTEGUMENT 03-25-09 7:06 2 HAIR LOSS VENTRAL THORACIC AREA 03-25-09 7:06 1 HAIR LOSS RIGHT FORELIMB 03-25-09 7:07 2 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 03-25-09 7:07 2 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-25-09 7:07 1 HAIR LOSS RIGHT HINDLIMB 03-25-09 7:07 1 HAIR LOSS LEFT HINDLIMB 03-27-09 7:29 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-27-09 7:29 2 HAIR LOSS VENTRAL THORACIC AREA 03-27-09 7:29 2 HAIR LOSS RIGHT HINDLIMB 03-27-09 7:29 2 HAIR LOSS LEFT HINDLIMB 03-27-09 7:29 1 HAIR LOSS RIGHT LATERAL ABDOMINAL AREA 03-27-09 7:29 2 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 3689 F 2500 PPM NORMAL 02-18-09 9:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3689 F 2500 PPM DISPOSITION 03-24-09 7:39 P SCHEDULED EUTHANASIA 3698 F 2500 PPM NORMAL 02-18-09 13:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3698 F 2500 PPM DISPOSITION 03-23-09 7:57 P SCHEDULED EUTHANASIA 3698 F 2500 PPM BODY/INTEGUMENT 03-18-09 7:56 2 HAIR LOSS RIGHT FORELIMB 03-18-09 7:56 2 HAIR LOSS LEFT FORELIMB 03-23-09 7:18 1 HAIR LOSS RIGHT FORELIMB 03-23-09 7:18 1 HAIR LOSS LEFT FORELIMB 3703 F 2500 PPM NORMAL 02-18-09 9:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 46 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3703 F 2500 PPM NORMAL 02-25-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3703 F 2500 PPM DISPOSITION 03-27-09 10:20 P SCHEDULED EUTHANASIA 3717 F 2500 PPM NORMAL 02-18-09 9:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3717 F 2500 PPM DISPOSITION 03-27-09 10:21 P SCHEDULED EUTHANASIA 3721 F 2500 PPM NORMAL 02-18-09 9:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3721 F 2500 PPM DISPOSITION 03-25-09 7:46 P SCHEDULED EUTHANASIA 3730 F 2500 PPM NORMAL 02-18-09 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3730 F 2500 PPM DISPOSITION 03-26-09 7:58 P SCHEDULED EUTHANASIA 3730 F 2500 PPM BODY/INTEGUMENT 03-11-09 7:38 1 HAIR LOSS DORSAL HEAD 03-18-09 7:58 1 HAIR LOSS DORSAL HEAD 03-25-09 7:08 1 HAIR LOSS RIGHT FORELIMB-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 47 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3730 F 2500 PPM BODY/INTEGUMENT 03-25-09 7:08 1 HAIR LOSS DORSAL HEAD 03-26-09 7:31 2 HAIR LOSS DORSAL HEAD 3742 F 2500 PPM NORMAL 02-18-09 13:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3742 F 2500 PPM DISPOSITION 03-22-09 12:00 P EUTHANIZED IN EXTREMIS 3742 F 2500 PPM BODY/INTEGUMENT 03-11-09 7:39 2 HAIR LOSS RIGHT HINDLIMB 03-11-09 7:39 2 HAIR LOSS LEFT HINDLIMB 03-11-09 7:39 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-11-09 7:39 1 HAIR LOSS RIGHT FORELIMB 03-11-09 7:39 1 HAIR LOSS LEFT FORELIMB 03-18-09 7:58 2 HAIR LOSS VENTRAL ABDOMINAL AREA 03-18-09 7:58 2 HAIR LOSS VENTRAL THORACIC AREA 03-18-09 7:59 1 HAIR LOSS RIGHT HINDLIMB 03-18-09 7:59 2 HAIR LOSS LEFT HINDLIMB 03-18-09 7:59 1 HAIR LOSS LEFT LATERAL ABDOMINAL AREA 3742 F 2500 PPM EYES/EARS/NOSE 03-18-09 7:58 1 DRIED RED MATERIAL AROUND RIGHT EYE 3753 F 2500 PPM NORMAL 02-18-09 9:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3753 F 2500 PPM DISPOSITION 03-27-09 6:54 P SCHEDULED EUTHANASIA 3755 F 2500 PPM NORMAL 02-18-09 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A1 (DETAILED PHYSICAL EXAMINATIONS/DISPOSITIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 48 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-18-09 TO 03-27-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3755 F 2500 PPM NORMAL 03-18-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3755 F 2500 PPM DISPOSITION 03-27-09 10:21 P SCHEDULED EUTHANASIA 3758 F 2500 PPM NORMAL 02-18-09 9:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-25-09 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-27-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3758 F 2500 PPM DISPOSITION 03-27-09 10:21 P SCHEDULED EUTHANASIA-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PCRDv4.11 05/18/2009 R:05/18/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3774 M 0 PPM NORMAL 02-25-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3776 M 0 PPM NORMAL 02-25-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3776 M 0 PPM NORMAL 03-01-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3780 M 0 PPM NORMAL 02-25-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3780 M 0 PPM NORMAL 03-02-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3787 M 0 PPM NORMAL 02-25-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3787 M 0 PPM NORMAL 03-06-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3789 M 0 PPM NORMAL 03-01-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3789 M 0 PPM NORMAL 03-10-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3790 M 0 PPM NORMAL 03-01-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3790 M 0 PPM NORMAL 03-13-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3791 M 0 PPM NORMAL 03-01-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3791 M 0 PPM NORMAL 03-16-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3802 M 0 PPM NORMAL 03-01-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3802 M 0 PPM NORMAL 03-19-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3803 M 0 PPM NORMAL 02-25-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3803 M 0 PPM NORMAL 03-18-09 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3811 M 0 PPM NORMAL 03-01-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3811 M 0 PPM NORMAL 03-25-09 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3826 M 0 PPM NORMAL 02-25-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3826 M 0 PPM NORMAL 03-24-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3828 M 0 PPM NORMAL 02-25-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3832 M 0 PPM NORMAL 02-25-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3832 M 0 PPM NORMAL 02-26-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3837 M 0 PPM NORMAL 02-25-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3837 M 0 PPM NORMAL 02-26-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3843 M 0 PPM NORMAL 02-25-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3843 M 0 PPM NORMAL 03-01-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3764 M 1000 PPM NORMAL 03-01-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3764 M 1000 PPM NORMAL 03-07-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3769 M 1000 PPM NORMAL 02-25-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3769 M 1000 PPM NORMAL 03-06-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3772 M 1000 PPM NORMAL 02-25-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3772 M 1000 PPM NORMAL 03-07-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3773 M 1000 PPM NORMAL 02-25-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3773 M 1000 PPM NORMAL 03-10-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3781 M 1000 PPM NORMAL 02-25-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3781 M 1000 PPM NORMAL 03-10-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3800 M 1000 PPM NORMAL 02-25-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3800 M 1000 PPM NORMAL 03-11-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3801 M 1000 PPM NORMAL 03-01-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 21 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3801 M 1000 PPM NORMAL 03-17-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3805 M 1000 PPM NORMAL 02-25-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 22 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3805 M 1000 PPM NORMAL 03-16-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3806 M 1000 PPM NORMAL 03-01-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 23 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3806 M 1000 PPM NORMAL 03-22-09 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3816 M 1000 PPM NORMAL 02-25-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 24 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3816 M 1000 PPM NORMAL 03-21-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3818 M 1000 PPM NORMAL 02-25-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3824 M 1000 PPM NORMAL 03-01-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 25 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3824 M 1000 PPM NORMAL 03-03-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3824 M 1000 PPM ORAL/DENTAL 03-15-09 6:41 P WET CLEAR MATERIAL AROUND MOUTH 3840 M 1000 PPM NORMAL 03-01-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 26 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3840 M 1000 PPM NORMAL 03-06-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3845 M 1000 PPM NORMAL 02-25-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 27 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3845 M 1000 PPM NORMAL 03-05-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3846 M 1000 PPM NORMAL 02-25-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 28 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3846 M 1000 PPM NORMAL 03-09-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3762 M 1500 PPM NORMAL 02-25-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 29 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3762 M 1500 PPM NORMAL 03-10-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3765 M 1500 PPM NORMAL 03-01-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 30 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3765 M 1500 PPM NORMAL 03-17-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3766 M 1500 PPM NORMAL 03-01-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 31 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3766 M 1500 PPM NORMAL 03-20-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3768 M 1500 PPM NORMAL 02-25-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 32 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3768 M 1500 PPM NORMAL 03-19-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3777 M 1500 PPM NORMAL 03-01-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 33 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3777 M 1500 PPM NORMAL 03-24-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3778 M 1500 PPM NORMAL 03-01-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 34 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3786 M 1500 PPM NORMAL 02-25-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 35 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3788 M 1500 PPM NORMAL 02-25-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3798 M 1500 PPM NORMAL 03-01-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 36 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3798 M 1500 PPM NORMAL 03-04-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3813 M 1500 PPM NORMAL 02-25-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 37 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3813 M 1500 PPM NORMAL 03-03-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3819 M 1500 PPM NORMAL 02-25-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 38 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3819 M 1500 PPM NORMAL 03-07-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3825 M 1500 PPM NORMAL 02-25-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 39 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3825 M 1500 PPM NORMAL 03-09-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3833 M 1500 PPM NORMAL 02-25-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 40 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3833 M 1500 PPM NORMAL 03-09-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3841 M 1500 PPM NORMAL 02-25-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 41 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3841 M 1500 PPM NORMAL 03-13-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3842 M 1500 PPM NORMAL 02-25-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 42 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3842 M 1500 PPM NORMAL 03-14-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3760 M 2000 PPM NORMAL 02-25-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 43 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3760 M 2000 PPM NORMAL 03-16-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3760 M 2000 PPM EYES/EARS/NOSE 03-22-09 9:20 P DRIED RED MATERIAL AROUND NOSE 3760 M 2000 PPM ORAL/DENTAL 03-22-09 9:20 P DRIED RED MATERIAL AROUND MOUTH 3770 M 2000 PPM NORMAL 02-25-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 44 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3770 M 2000 PPM NORMAL 03-17-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3779 M 2000 PPM NORMAL 02-25-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 45 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3779 M 2000 PPM NORMAL 03-23-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3782 M 2000 PPM NORMAL 02-25-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 46 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3782 M 2000 PPM NORMAL 03-23-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3784 M 2000 PPM NORMAL 02-25-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 47 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3792 M 2000 PPM NORMAL 03-01-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3793 M 2000 PPM NORMAL 02-25-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 48 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3793 M 2000 PPM NORMAL 02-28-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3794 M 2000 PPM NORMAL 02-25-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 49 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3794 M 2000 PPM NORMAL 03-01-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3799 M 2000 PPM NORMAL 03-01-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 50 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3799 M 2000 PPM NORMAL 03-08-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3809 M 2000 PPM NORMAL 03-01-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 51 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3809 M 2000 PPM NORMAL 03-11-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3812 M 2000 PPM NORMAL 03-01-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 52 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3812 M 2000 PPM NORMAL 03-14-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3815 M 2000 PPM NORMAL 03-01-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 53 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3815 M 2000 PPM NORMAL 03-17-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3820 M 2000 PPM NORMAL 02-25-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 54 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3820 M 2000 PPM NORMAL 03-16-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3821 M 2000 PPM NORMAL 02-25-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 55 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3821 M 2000 PPM NORMAL 03-18-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3838 M 2000 PPM NORMAL 02-25-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 56 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3838 M 2000 PPM NORMAL 03-20-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3838 M 2000 PPM ORAL/DENTAL 03-14-09 7:13 P DRIED RED MATERIAL AROUND MOUTH 3763 M 2500 PPM NORMAL 02-25-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 57 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3767 M 2500 PPM NORMAL 02-25-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3771 M 2500 PPM NORMAL 02-25-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 58 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3771 M 2500 PPM NORMAL 03-01-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3775 M 2500 PPM NORMAL 02-25-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 59 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3775 M 2500 PPM NORMAL 03-03-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3783 M 2500 PPM NORMAL 03-01-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 60 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3783 M 2500 PPM NORMAL 03-07-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3785 M 2500 PPM NORMAL 03-01-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 61 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3785 M 2500 PPM NORMAL 03-10-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3795 M 2500 PPM NORMAL 02-25-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 62 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3795 M 2500 PPM NORMAL 03-09-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3795 M 2500 PPM EYES/EARS/NOSE 03-22-09 9:26 P DRIED RED MATERIAL AROUND NOSE 3804 M 2500 PPM NORMAL 02-25-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 63 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3804 M 2500 PPM NORMAL 03-10-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3807 M 2500 PPM NORMAL 03-01-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 64 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3807 M 2500 PPM NORMAL 03-16-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3810 M 2500 PPM NORMAL 03-01-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 65 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3810 M 2500 PPM NORMAL 03-19-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3814 M 2500 PPM NORMAL 02-25-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 66 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3814 M 2500 PPM NORMAL 03-18-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3817 M 2500 PPM NORMAL 02-25-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 67 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3817 M 2500 PPM NORMAL 03-21-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3822 M 2500 PPM NORMAL 02-25-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 68 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3822 M 2500 PPM NORMAL 03-22-09 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3831 M 2500 PPM NORMAL 03-01-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 69 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3831 M 2500 PPM NORMAL 03-26-09 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3839 M 2500 PPM NORMAL 02-25-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3677 F 0 PPM NORMAL 02-25-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 70 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3677 F 0 PPM NORMAL 02-28-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3677 F 0 PPM EYES/EARS/NOSE 03-22-09 9:03 P DRIED RED MATERIAL AROUND NOSE 3686 F 0 PPM NORMAL 02-25-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 71 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3686 F 0 PPM NORMAL 02-28-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3691 F 0 PPM NORMAL 03-01-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 72 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3691 F 0 PPM NORMAL 03-05-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3693 F 0 PPM NORMAL 03-01-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 73 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3693 F 0 PPM NORMAL 03-08-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3694 F 0 PPM NORMAL 02-25-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 74 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3694 F 0 PPM NORMAL 03-07-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3696 F 0 PPM NORMAL 02-25-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 75 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3696 F 0 PPM NORMAL 03-08-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3704 F 0 PPM NORMAL 02-25-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 76 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3704 F 0 PPM NORMAL 03-08-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3714 F 0 PPM NORMAL 02-25-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 77 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3714 F 0 PPM NORMAL 03-12-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3719 F 0 PPM NORMAL 03-01-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 78 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3719 F 0 PPM NORMAL 03-18-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3723 F 0 PPM NORMAL 03-01-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 79 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3723 F 0 PPM NORMAL 03-21-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3725 F 0 PPM NORMAL 02-25-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 80 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3725 F 0 PPM NORMAL 03-20-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3733 F 0 PPM NORMAL 03-01-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 81 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3738 F 0 PPM NORMAL 02-25-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3744 F 0 PPM NORMAL 02-25-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 82 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3744 F 0 PPM NORMAL 02-28-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3757 F 0 PPM NORMAL 02-25-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 83 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3757 F 0 PPM NORMAL 03-04-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3672 F 1000 PPM NORMAL 03-01-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 84 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3672 F 1000 PPM NORMAL 03-11-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3675 F 1000 PPM NORMAL 02-25-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 85 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3675 F 1000 PPM NORMAL 03-10-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3683 F 1000 PPM NORMAL 03-01-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 86 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3683 F 1000 PPM NORMAL 03-18-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3690 F 1000 PPM NORMAL 03-01-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 87 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3690 F 1000 PPM NORMAL 03-21-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3695 F 1000 PPM NORMAL 02-25-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 88 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3695 F 1000 PPM NORMAL 03-20-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3697 F 1000 PPM NORMAL 03-01-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 89 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3697 F 1000 PPM NORMAL 03-24-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3700 F 1000 PPM NORMAL 02-25-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 90 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3702 F 1000 PPM NORMAL 02-25-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3706 F 1000 PPM NORMAL 03-01-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 91 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3706 F 1000 PPM NORMAL 03-05-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 8:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3712 F 1000 PPM NORMAL 02-25-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 92 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3712 F 1000 PPM NORMAL 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3713 F 1000 PPM NORMAL 02-25-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 93 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3713 F 1000 PPM NORMAL 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3718 F 1000 PPM NORMAL 02-25-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 94 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3718 F 1000 PPM NORMAL 03-05-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3720 F 1000 PPM NORMAL 02-25-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 95 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3720 F 1000 PPM NORMAL 03-07-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3743 F 1000 PPM NORMAL 02-25-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 96 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3743 F 1000 PPM NORMAL 03-09-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3747 F 1000 PPM NORMAL 02-25-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 97 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3747 F 1000 PPM NORMAL 03-10-09 7:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3674 F 1500 PPM NORMAL 02-25-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 98 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3674 F 1500 PPM NORMAL 03-13-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3674 F 1500 PPM EYES/EARS/NOSE 03-19-09 7:34 P DRIED RED MATERIAL AROUND LEFT EYE 03-20-09 6:48 P DRIED RED MATERIAL AROUND LEFT EYE 3684 F 1500 PPM NORMAL 03-01-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 99 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3684 F 1500 PPM NORMAL 03-21-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3701 F 1500 PPM NORMAL 02-25-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 100 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3701 F 1500 PPM NORMAL 03-20-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3708 F 1500 PPM NORMAL 02-25-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 101 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3708 F 1500 PPM NORMAL 03-23-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3711 F 1500 PPM NORMAL 02-25-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 102 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3711 F 1500 PPM NORMAL 03-25-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3722 F 1500 PPM NORMAL 02-25-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 103 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3724 F 1500 PPM NORMAL 03-01-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3724 F 1500 PPM EYES/EARS/NOSE 03-22-09 9:13 P DRIED RED MATERIAL AROUND NOSE 03-24-09 8:38 P DRIED RED MATERIAL AROUND NOSE 3726 F 1500 PPM NORMAL 02-25-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 104 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3726 F 1500 PPM NORMAL 02-28-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3727 F 1500 PPM NORMAL 02-25-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 105 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3727 F 1500 PPM NORMAL 03-01-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3727 F 1500 PPM EYES/EARS/NOSE 03-23-09 8:35 P DRIED RED MATERIAL AROUND NOSE 3728 F 1500 PPM NORMAL 03-01-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 106 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3728 F 1500 PPM NORMAL 03-05-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3729 F 1500 PPM NORMAL 03-01-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 107 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3729 F 1500 PPM NORMAL 03-08-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3729 F 1500 PPM EYES/EARS/NOSE 03-24-09 8:40 P DRIED RED MATERIAL AROUND NOSE 3731 F 1500 PPM NORMAL 02-25-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 108 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3731 F 1500 PPM NORMAL 03-07-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3734 F 1500 PPM NORMAL 02-25-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 109 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3734 F 1500 PPM NORMAL 03-09-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3748 F 1500 PPM NORMAL 03-01-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 110 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3748 F 1500 PPM NORMAL 03-17-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3756 F 1500 PPM NORMAL 02-25-09 8:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 7:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 111 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3756 F 1500 PPM NORMAL 03-16-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3676 F 2000 PPM NORMAL 02-25-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 112 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3676 F 2000 PPM NORMAL 03-19-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3678 F 2000 PPM NORMAL 02-25-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 113 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3678 F 2000 PPM NORMAL 03-19-09 7:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3682 F 2000 PPM NORMAL 03-01-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 114 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3682 F 2000 PPM NORMAL 03-26-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3705 F 2000 PPM NORMAL 03-01-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3709 F 2000 PPM NORMAL 02-25-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 115 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3709 F 2000 PPM NORMAL 02-27-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3710 F 2000 PPM NORMAL 03-01-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 116 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3710 F 2000 PPM NORMAL 03-04-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3710 F 2000 PPM EYES/EARS/NOSE 03-23-09 8:39 P DRIED RED MATERIAL AROUND NOSE 3716 F 2000 PPM NORMAL 02-25-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 117 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3716 F 2000 PPM NORMAL 03-03-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3732 F 2000 PPM NORMAL 02-25-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 118 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3732 F 2000 PPM NORMAL 03-06-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3739 F 2000 PPM NORMAL 02-25-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 119 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3739 F 2000 PPM NORMAL 03-10-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3739 F 2000 PPM EYES/EARS/NOSE 03-21-09 6:41 P DRIED RED MATERIAL AROUND NOSE 3740 F 2000 PPM NORMAL 03-01-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 120 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3740 F 2000 PPM NORMAL 03-16-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3745 F 2000 PPM NORMAL 02-25-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 121 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3745 F 2000 PPM NORMAL 03-15-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3746 F 2000 PPM NORMAL 02-25-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 122 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3746 F 2000 PPM NORMAL 03-19-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3749 F 2000 PPM NORMAL 03-01-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 123 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3749 F 2000 PPM NORMAL 03-25-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3751 F 2000 PPM NORMAL 02-25-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 124 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3751 F 2000 PPM NORMAL 03-24-09 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3754 F 2000 PPM NORMAL 02-25-09 8:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 6:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 6:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 125 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3754 F 2000 PPM NORMAL 03-25-09 8:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3673 F 2500 PPM NORMAL 02-25-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3679 F 2500 PPM NORMAL 02-25-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 126 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3679 F 2500 PPM NORMAL 02-26-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3680 F 2500 PPM NORMAL 02-25-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 127 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3680 F 2500 PPM NORMAL 03-01-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3685 F 2500 PPM NORMAL 02-25-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 128 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3685 F 2500 PPM NORMAL 03-02-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3688 F 2500 PPM NORMAL 03-01-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 129 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3688 F 2500 PPM NORMAL 03-06-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3689 F 2500 PPM NORMAL 02-25-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 130 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3689 F 2500 PPM NORMAL 03-05-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3698 F 2500 PPM NORMAL 02-25-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 131 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3698 F 2500 PPM NORMAL 03-08-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3703 F 2500 PPM NORMAL 03-01-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 132 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3703 F 2500 PPM NORMAL 03-16-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3717 F 2500 PPM NORMAL 03-01-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 133 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3717 F 2500 PPM NORMAL 03-19-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3721 F 2500 PPM NORMAL 02-25-09 8:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 134 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3721 F 2500 PPM NORMAL 03-18-09 8:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3730 F 2500 PPM NORMAL 02-25-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 135 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3730 F 2500 PPM NORMAL 03-20-09 7:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3742 F 2500 PPM NORMAL 02-25-09 8:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3742 F 2500 PPM EYES/EARS/NOSE 03-16-09 7:25 P DRIED RED MATERIAL AROUND RIGHT EYE 03-17-09 6:54 P DRIED RED MATERIAL AROUND RIGHT EYE 03-20-09 7:06 P DRIED RED MATERIAL AROUND RIGHT EYE-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 136 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3742 F 2500 PPM EYES/EARS/NOSE 03-21-09 6:48 P DRIED RED MATERIAL AROUND RIGHT EYE 3753 F 2500 PPM NORMAL 02-25-09 8:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 6:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-27-09 8:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-28-09 7:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 137 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3753 F 2500 PPM NORMAL 03-25-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3755 F 2500 PPM NORMAL 03-01-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3758 F 2500 PPM NORMAL 03-01-09 6:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A2 (PRIOR TO EXPOSURE/NON-EXPOSURE DAY OBSERVATIONS - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 138 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3758 F 2500 PPM NORMAL 03-03-09 6:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 8:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 7:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-06-09 6:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-07-09 6:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 6:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 6:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 7:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 8:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 6:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-13-09 8:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-14-09 7:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 7:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 7:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 6:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 8:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 7:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-20-09 7:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 6:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 9:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 8:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 8:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 8:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 9:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PCRDv4.11 05/11/2009 R:05/18/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A3 (MIDPOINT OF EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3792 M 2000 PPM BEHAVIOR/CNS 03-16-09 11:14 P INTERMITTENT TREMORS 03-22-09 14:02 P INTERMITTENT TREMORS 3799 M 2000 PPM BEHAVIOR/CNS 03-04-09 12:01 P INTERMITTENT TREMORS 03-05-09 11:46 P INTERMITTENT TREMORS 03-08-09 10:37 P INTERMITTENT TREMORS 03-18-09 12:18 P INTERMITTENT TREMORS 03-22-09 14:01 P INTERMITTENT TREMORS 03-24-09 13:31 P INTERMITTENT TREMORS 3809 M 2000 PPM BEHAVIOR/CNS 03-11-09 12:04 P INTERMITTENT TREMORS 3838 M 2000 PPM BEHAVIOR/CNS 03-08-09 10:37 P INTERMITTENT TREMORS 03-10-09 11:35 P INTERMITTENT TREMORS 03-12-09 11:11 P INTERMITTENT TREMORS 3767 M 2500 PPM BEHAVIOR/CNS 03-04-09 11:54 P INTERMITTENT TREMORS 03-12-09 11:05 P INTERMITTENT TREMORS 3771 M 2500 PPM BEHAVIOR/CNS 03-19-09 11:23 P INTERMITTENT TREMORS 3775 M 2500 PPM BEHAVIOR/CNS 03-11-09 12:03 P INTERMITTENT TREMORS 3783 M 2500 PPM BEHAVIOR/CNS 03-02-09 11:22 P INTERMITTENT TREMORS 03-03-09 10:52 P INTERMITTENT TREMORS 03-04-09 11:53 P INTERMITTENT TREMORS 03-08-09 10:31 P INTERMITTENT TREMORS 03-15-09 10:54 P INTERMITTENT TREMORS 03-16-09 11:15 P INTERMITTENT TREMORS 03-17-09 11:10 P INTERMITTENT TREMORS 03-18-09 12:15 P CONTINUOUS TREMORS 03-23-09 13:37 P INTERMITTENT TREMORS 03-24-09 13:30 P INTERMITTENT TREMORS 03-25-09 14:21 P CONTINUOUS TREMORS 03-26-09 13:41 P CONTINUOUS TREMORS 3795 M 2500 PPM BEHAVIOR/CNS 03-19-09 11:25 P INTERMITTENT TREMORS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A3 (MIDPOINT OF EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3795 M 2500 PPM BEHAVIOR/CNS 03-23-09 13:40 P INTERMITTENT TREMORS 03-25-09 14:20 P INTERMITTENT TREMORS 3807 M 2500 PPM BEHAVIOR/CNS 03-15-09 10:54 P INTERMITTENT TREMORS 03-16-09 11:18 P INTERMITTENT TREMORS 3810 M 2500 PPM BEHAVIOR/CNS 03-19-09 11:24 P INTERMITTENT TREMORS 03-22-09 13:57 P INTERMITTENT TREMORS 3817 M 2500 PPM BEHAVIOR/CNS 03-11-09 12:01 P INTERMITTENT TREMORS 03-18-09 12:16 P INTERMITTENT TREMORS 3822 M 2500 PPM BEHAVIOR/CNS 03-21-09 10:27 P INTERMITTENT TREMORS 3831 M 2500 PPM BEHAVIOR/CNS 03-05-09 11:42 P INTERMITTENT TREMORS 03-08-09 10:31 P INTERMITTENT TREMORS 03-10-09 11:31 P INTERMITTENT TREMORS 03-17-09 11:09 P INTERMITTENT TREMORS 03-18-09 12:14 P INTERMITTENT TREMORS 03-19-09 11:27 P INTERMITTENT TREMORS 03-22-09 13:57 P INTERMITTENT TREMORS 03-23-09 13:37 P INTERMITTENT TREMORS 03-26-09 13:41 P INTERMITTENT TREMORS 3839 M 2500 PPM BEHAVIOR/CNS 03-02-09 11:22 P INTERMITTENT TREMORS 03-08-09 10:32 P INTERMITTENT TREMORS 03-09-09 11:30 P INTERMITTENT TREMORS 03-16-09 11:17 P INTERMITTENT TREMORS 03-21-09 10:26 P INTERMITTENT TREMORS 03-22-09 14:00 P CONTINUOUS TREMORS 3678 F 2000 PPM BEHAVIOR/CNS 03-05-09 11:45 P INTERMITTENT TREMORS 03-17-09 11:12 P INTERMITTENT TREMORS 3740 F 2000 PPM BEHAVIOR/CNS 03-05-09 11:45 P INTERMITTENT TREMORS 03-09-09 11:29 P INTERMITTENT TREMORS 03-10-09 11:35 P INTERMITTENT TREMORS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A3 (MIDPOINT OF EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3740 F 2000 PPM BEHAVIOR/CNS 03-11-09 12:04 P INTERMITTENT TREMORS 03-12-09 11:11 P INTERMITTENT TREMORS 03-17-09 11:11 P INTERMITTENT TREMORS 03-18-09 12:18 P INTERMITTENT TREMORS 03-19-09 11:27 P INTERMITTENT TREMORS 03-22-09 14:01 P INTERMITTENT TREMORS 03-23-09 13:41 P INTERMITTENT TREMORS 03-24-09 13:32 P INTERMITTENT TREMORS 03-25-09 14:22 P INTERMITTENT TREMORS 03-26-09 13:42 P INTERMITTENT TREMORS 3685 F 2500 PPM BEHAVIOR/CNS 03-04-09 11:54 P INTERMITTENT TREMORS 03-05-09 11:43 P INTERMITTENT TREMORS 03-09-09 11:30 P INTERMITTENT TREMORS 03-10-09 11:33 P INTERMITTENT TREMORS 03-11-09 12:02 P INTERMITTENT TREMORS 03-12-09 11:06 P INTERMITTENT TREMORS 03-16-09 11:18 P INTERMITTENT TREMORS 03-17-09 11:07 P CONTINUOUS TREMORS 03-18-09 12:15 P CONTINUOUS TREMORS 03-19-09 11:26 P CONTINUOUS TREMORS 03-21-09 10:26 P CONTINUOUS TREMORS 03-22-09 13:59 P INTERMITTENT TREMORS 03-25-09 14:21 P CONTINUOUS TREMORS 03-26-09 13:41 P CONTINUOUS TREMORS 3688 F 2500 PPM BEHAVIOR/CNS 03-19-09 11:23 P INTERMITTENT TREMORS 3689 F 2500 PPM BEHAVIOR/CNS 03-22-09 14:00 P INTERMITTENT TREMORS 03-23-09 13:38 P CONTINUOUS TREMORS 3698 F 2500 PPM BEHAVIOR/CNS 03-21-09 10:27 P INTERMITTENT TREMORS 3703 F 2500 PPM BEHAVIOR/CNS 03-19-09 11:26 P INTERMITTENT TREMORS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A3 (MIDPOINT OF EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3717 F 2500 PPM BEHAVIOR/CNS 03-10-09 11:34 P INTERMITTENT TREMORS 03-23-09 13:37 P INTERMITTENT TREMORS 03-25-09 14:21 P INTERMITTENT TREMORS 03-26-09 13:41 P INTERMITTENT TREMORS 3721 F 2500 PPM BEHAVIOR/CNS 03-08-09 10:34 P INTERMITTENT TREMORS 3742 F 2500 PPM BEHAVIOR/CNS 03-02-09 11:22 P INTERMITTENT TREMORS 03-03-09 10:52 P INTERMITTENT TREMORS 03-04-09 11:53 P INTERMITTENT TREMORS 03-05-09 11:42 P INTERMITTENT TREMORS 03-09-09 11:29 P INTERMITTENT TREMORS 03-10-09 11:31 P INTERMITTENT TREMORS 03-11-09 12:02 P INTERMITTENT TREMORS 03-12-09 11:05 P INTERMITTENT TREMORS 03-16-09 11:17 P INTERMITTENT TREMORS 03-21-09 10:26 P INTERMITTENT TREMORS 3753 F 2500 PPM BEHAVIOR/CNS 03-21-09 10:28 P INTERMITTENT TREMORS 3758 F 2500 PPM BEHAVIOR/CNS 03-23-09 13:38 P INTERMITTENT TREMORS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PCRDv4.11 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3774 M 0 PPM NORMAL 02-25-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3776 M 0 PPM NORMAL 02-25-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3776 M 0 PPM NORMAL 03-11-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3780 M 0 PPM NORMAL 02-25-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3780 M 0 PPM NORMAL 03-21-09 13:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3787 M 0 PPM NORMAL 02-25-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3789 M 0 PPM NORMAL 03-01-09 14:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3789 M 0 PPM NORMAL 03-05-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3790 M 0 PPM NORMAL 03-01-09 14:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3790 M 0 PPM NORMAL 03-18-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3791 M 0 PPM NORMAL 03-01-09 14:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3802 M 0 PPM NORMAL 03-01-09 14:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3802 M 0 PPM NORMAL 03-03-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3803 M 0 PPM NORMAL 02-25-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3803 M 0 PPM NORMAL 03-12-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3811 M 0 PPM NORMAL 03-01-09 14:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3811 M 0 PPM EYES/EARS/NOSE 03-17-09 14:19 P WET RED MATERIAL AROUND NOSE 03-23-09 16:47 P DRIED RED MATERIAL AROUND NOSE 03-26-09 16:51 P WET RED MATERIAL AROUND NOSE-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3826 M 0 PPM NORMAL 02-25-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3828 M 0 PPM NORMAL 02-25-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3828 M 0 PPM NORMAL 03-08-09 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3832 M 0 PPM NORMAL 02-25-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3832 M 0 PPM NORMAL 03-18-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3837 M 0 PPM NORMAL 02-25-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3843 M 0 PPM NORMAL 02-25-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3843 M 0 PPM NORMAL 02-26-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3843 M 0 PPM EYES/EARS/NOSE 03-10-09 15:01 P DRIED RED MATERIAL AROUND NOSE 03-16-09 14:29 P DRIED RED MATERIAL AROUND NOSE 3764 M 1000 PPM NORMAL 03-01-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3764 M 1000 PPM NORMAL 03-12-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3769 M 1000 PPM NORMAL 02-25-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3769 M 1000 PPM NORMAL 03-23-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3769 M 1000 PPM EYES/EARS/NOSE 03-21-09 13:54 P DRIED RED MATERIAL AROUND NOSE 3772 M 1000 PPM NORMAL 02-25-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3773 M 1000 PPM NORMAL 02-25-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3773 M 1000 PPM NORMAL 03-04-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3781 M 1000 PPM NORMAL 02-25-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3781 M 1000 PPM NORMAL 03-12-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3800 M 1000 PPM NORMAL 02-25-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3800 M 1000 PPM NORMAL 03-22-09 17:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3801 M 1000 PPM NORMAL 03-01-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3801 M 1000 PPM EYES/EARS/NOSE 03-18-09 15:45 P DRIED RED MATERIAL AROUND NOSE 3805 M 1000 PPM NORMAL 02-25-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3805 M 1000 PPM NORMAL 03-05-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3806 M 1000 PPM NORMAL 03-01-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3806 M 1000 PPM NORMAL 03-22-09 17:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3806 M 1000 PPM ORAL/DENTAL 03-15-09 14:13 P DRIED CLEAR MATERIAL AROUND MOUTH 3816 M 1000 PPM NORMAL 02-25-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3816 M 1000 PPM ORAL/DENTAL 03-15-09 14:14 P DRIED CLEAR MATERIAL AROUND MOUTH 3818 M 1000 PPM NORMAL 02-25-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3818 M 1000 PPM NORMAL 03-03-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3824 M 1000 PPM NORMAL 03-01-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3824 M 1000 PPM NORMAL 03-18-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3840 M 1000 PPM NORMAL 03-01-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3845 M 1000 PPM NORMAL 02-25-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 21 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3845 M 1000 PPM NORMAL 03-01-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3846 M 1000 PPM NORMAL 02-25-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 22 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3846 M 1000 PPM NORMAL 03-15-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3762 M 1500 PPM NORMAL 02-25-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 23 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3762 M 1500 PPM NORMAL 03-22-09 17:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3765 M 1500 PPM NORMAL 03-01-09 14:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3765 M 1500 PPM EYES/EARS/NOSE 03-17-09 14:49 P WET RED MATERIAL AROUND NOSE 3766 M 1500 PPM NORMAL 03-01-09 14:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 24 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3766 M 1500 PPM NORMAL 03-10-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3768 M 1500 PPM NORMAL 02-25-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 25 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3768 M 1500 PPM NORMAL 03-21-09 14:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3768 M 1500 PPM BODY/INTEGUMENT 03-16-09 14:49 P LIMBS COOL 3777 M 1500 PPM NORMAL 03-01-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3778 M 1500 PPM NORMAL 03-01-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 26 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3778 M 1500 PPM NORMAL 03-04-09 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3786 M 1500 PPM NORMAL 02-25-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 27 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3786 M 1500 PPM NORMAL 03-16-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3786 M 1500 PPM BODY/INTEGUMENT 03-12-09 14:43 P LIMBS COOL 03-22-09 17:34 P LIMBS COOL 3786 M 1500 PPM EYES/EARS/NOSE 03-23-09 17:15 P DRIED RED MATERIAL AROUND NOSE 03-24-09 16:59 P WET RED MATERIAL AROUND NOSE 3788 M 1500 PPM NORMAL 02-25-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 28 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3788 M 1500 PPM BODY/INTEGUMENT 03-16-09 14:50 P LIMBS COOL 3788 M 1500 PPM EYES/EARS/NOSE 03-23-09 17:15 P WET RED MATERIAL AROUND NOSE 3798 M 1500 PPM NORMAL 03-01-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3798 M 1500 PPM EYES/EARS/NOSE 03-19-09 15:06 P WET RED MATERIAL AROUND NOSE 3813 M 1500 PPM NORMAL 02-25-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 29 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3813 M 1500 PPM NORMAL 03-08-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3813 M 1500 PPM BODY/INTEGUMENT 03-12-09 14:44 P LIMBS COOL 03-22-09 17:34 P LIMBS COOL 3819 M 1500 PPM NORMAL 02-25-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 30 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3819 M 1500 PPM NORMAL 03-22-09 17:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3819 M 1500 PPM BODY/INTEGUMENT 03-23-09 17:16 P LIMBS COOL 3819 M 1500 PPM EYES/EARS/NOSE 03-17-09 14:51 P DRIED RED MATERIAL AROUND NOSE 3825 M 1500 PPM NORMAL 02-25-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3825 M 1500 PPM BODY/INTEGUMENT 03-12-09 14:45 P LIMBS COOL 03-16-09 14:51 P LIMBS COOL 03-18-09 15:52 P LIMBS COOL 03-22-09 17:35 P LIMBS COOL 03-26-09 17:13 P LIMBS COOL 3833 M 1500 PPM NORMAL 02-25-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 31 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3833 M 1500 PPM NORMAL 03-01-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3833 M 1500 PPM EYES/EARS/NOSE 03-21-09 14:07 P DRIED RED MATERIAL AROUND NOSE 3841 M 1500 PPM NORMAL 02-25-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 32 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3841 M 1500 PPM NORMAL 03-15-09 14:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3841 M 1500 PPM EYES/EARS/NOSE 03-17-09 14:52 P DRIED RED MATERIAL AROUND NOSE 03-25-09 17:56 P DRIED RED MATERIAL AROUND NOSE 3842 M 1500 PPM NORMAL 02-25-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 33 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3842 M 1500 PPM NORMAL 03-23-09 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3760 M 2000 PPM NORMAL 02-25-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3760 M 2000 PPM BODY/INTEGUMENT 03-16-09 14:55 P LIMBS COOL 3760 M 2000 PPM EYES/EARS/NOSE 03-19-09 15:11 P DRIED RED MATERIAL AROUND NOSE 03-21-09 14:11 P DRIED RED MATERIAL AROUND NOSE 03-22-09 17:37 P DRIED RED MATERIAL AROUND NOSE 3760 M 2000 PPM ORAL/DENTAL 03-21-09 14:11 P DRIED RED MATERIAL AROUND MOUTH 3770 M 2000 PPM NORMAL 02-25-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 34 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3770 M 2000 PPM NORMAL 03-04-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3779 M 2000 PPM NORMAL 02-25-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3779 M 2000 PPM BODY/INTEGUMENT 03-10-09 15:32 P LIMBS COOL-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 35 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3779 M 2000 PPM BODY/INTEGUMENT 03-11-09 15:50 P LIMBS COOL 3779 M 2000 PPM EYES/EARS/NOSE 03-19-09 15:11 P DRIED RED MATERIAL AROUND NOSE 03-21-09 14:13 P DRIED RED MATERIAL AROUND NOSE 03-22-09 17:38 P DRIED RED MATERIAL AROUND NOSE 03-23-09 17:20 P DRIED RED MATERIAL AROUND NOSE 3782 M 2000 PPM NORMAL 02-25-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3782 M 2000 PPM BODY/INTEGUMENT 03-16-09 14:56 P LIMBS COOL 03-26-09 17:17 P LIMBS COOL 3784 M 2000 PPM NORMAL 02-25-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 36 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3784 M 2000 PPM NORMAL 02-26-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3784 M 2000 PPM BODY/INTEGUMENT 03-09-09 15:15 P LIMBS COOL 03-10-09 15:35 P LIMBS COOL 03-21-09 14:13 P LIMBS COOL 3792 M 2000 PPM NORMAL 03-01-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 37 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3792 M 2000 PPM NORMAL 03-15-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3793 M 2000 PPM NORMAL 02-25-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 38 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3793 M 2000 PPM BODY/INTEGUMENT 03-10-09 15:35 P LIMBS COOL 03-11-09 15:51 P LIMBS COOL 03-23-09 17:21 P LIMBS COOL 3794 M 2000 PPM NORMAL 02-25-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3794 M 2000 PPM BEHAVIOR/CNS 03-05-09 15:33 P INTERMITTENT TREMORS 3794 M 2000 PPM BODY/INTEGUMENT 03-10-09 15:35 P LIMBS COOL 03-11-09 15:51 P LIMBS COOL 3799 M 2000 PPM NORMAL 03-01-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 39 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3799 M 2000 PPM NORMAL 03-11-09 15:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3799 M 2000 PPM BODY/INTEGUMENT 03-04-09 15:52 P LIMBS COOL 03-08-09 14:30 P LIMBS COOL 3799 M 2000 PPM EYES/EARS/NOSE 03-19-09 15:12 P WET RED MATERIAL AROUND NOSE 03-23-09 17:21 P WET RED MATERIAL AROUND NOSE 03-24-09 17:07 P DRIED RED MATERIAL AROUND NOSE 03-26-09 17:17 P DRIED RED MATERIAL AROUND NOSE 3809 M 2000 PPM NORMAL 03-01-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 40 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3809 M 2000 PPM NORMAL 03-22-09 17:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3812 M 2000 PPM NORMAL 03-01-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3812 M 2000 PPM BODY/INTEGUMENT 03-19-09 15:13 P LIMBS COOL 3812 M 2000 PPM EYES/EARS/NOSE 03-18-09 15:59 P DRIED RED MATERIAL AROUND NOSE 03-25-09 18:01 P DRIED RED MATERIAL AROUND NOSE 3815 M 2000 PPM NORMAL 03-01-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 41 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3815 M 2000 PPM NORMAL 03-05-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3815 M 2000 PPM EYES/EARS/NOSE 03-10-09 15:36 P DRIED RED MATERIAL AROUND NOSE 03-11-09 15:53 P WET RED MATERIAL AROUND NOSE 03-22-09 17:41 P DRIED RED MATERIAL AROUND RIGHT EYE 03-24-09 17:07 P DRIED RED MATERIAL AROUND RIGHT EYE 03-25-09 18:01 P DRIED RED MATERIAL AROUND RIGHT EYE 3820 M 2000 PPM NORMAL 02-25-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 42 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3820 M 2000 PPM NORMAL 03-16-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3821 M 2000 PPM NORMAL 02-25-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 43 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3821 M 2000 PPM BODY/INTEGUMENT 03-18-09 15:59 P LIMBS COOL 3838 M 2000 PPM NORMAL 02-25-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3838 M 2000 PPM BODY/INTEGUMENT 03-10-09 15:37 P LIMBS COOL 3763 M 2500 PPM NORMAL 02-25-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 44 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3763 M 2500 PPM NORMAL 03-10-09 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3767 M 2500 PPM NORMAL 02-25-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3767 M 2500 PPM BODY/INTEGUMENT 03-03-09 14:56 P LIMBS COOL 03-08-09 14:36 P LIMBS COOL 03-09-09 15:22 P LIMBS COOL 03-11-09 15:57 P LIMBS COOL-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 45 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3767 M 2500 PPM EYES/EARS/NOSE 03-22-09 17:45 P DRIED RED MATERIAL AROUND NOSE 3771 M 2500 PPM NORMAL 02-25-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3771 M 2500 PPM BODY/INTEGUMENT 03-17-09 15:04 P LIMBS COOL 3771 M 2500 PPM EYES/EARS/NOSE 03-23-09 17:25 P DRIED RED MATERIAL AROUND NOSE 03-24-09 17:12 P DRIED RED MATERIAL AROUND NOSE 3771 M 2500 PPM ORAL/DENTAL 03-23-09 17:25 P DRIED RED MATERIAL AROUND MOUTH 03-24-09 17:12 P DRIED RED MATERIAL AROUND MOUTH 3775 M 2500 PPM NORMAL 02-25-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 46 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3775 M 2500 PPM NORMAL 03-04-09 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3783 M 2500 PPM NORMAL 03-01-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 47 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3783 M 2500 PPM NORMAL 03-17-09 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3783 M 2500 PPM BODY/INTEGUMENT 03-10-09 15:40 P LIMBS COOL 03-24-09 17:13 P LIMBS COOL 3785 M 2500 PPM NORMAL 03-01-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3785 M 2500 PPM BODY/INTEGUMENT 03-03-09 14:57 P LIMBS COOL 03-05-09 15:43 P LIMBS COOL-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 48 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3795 M 2500 PPM NORMAL 02-25-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3795 M 2500 PPM BODY/INTEGUMENT 03-03-09 14:57 P LIMBS COOL 03-10-09 15:41 P LIMBS COOL 03-11-09 15:58 P LIMBS COOL 03-22-09 17:46 P LIMBS COOL 3795 M 2500 PPM EYES/EARS/NOSE 03-21-09 14:20 P DRIED RED MATERIAL AROUND NOSE 3804 M 2500 PPM NORMAL 02-25-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 49 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3804 M 2500 PPM NORMAL 03-08-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3804 M 2500 PPM ORAL/DENTAL 03-15-09 14:48 P DRIED RED MATERIAL AROUND MOUTH 3807 M 2500 PPM NORMAL 03-01-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3807 M 2500 PPM BODY/INTEGUMENT 03-03-09 14:58 P LIMBS COOL-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 50 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3807 M 2500 PPM BODY/INTEGUMENT 03-04-09 16:00 P LIMBS COOL 03-05-09 15:44 P LIMBS COOL 03-09-09 15:23 P LIMBS COOL 03-17-09 15:05 P LIMBS COOL 3807 M 2500 PPM EYES/EARS/NOSE 03-26-09 17:20 P DRIED RED MATERIAL AROUND NOSE 3807 M 2500 PPM ORAL/DENTAL 03-26-09 17:20 P DRIED RED MATERIAL AROUND MOUTH 3810 M 2500 PPM NORMAL 03-01-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3810 M 2500 PPM EYES/EARS/NOSE 03-19-09 15:20 P DRIED RED MATERIAL AROUND NOSE 3814 M 2500 PPM NORMAL 02-25-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 51 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3814 M 2500 PPM NORMAL 03-02-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3814 M 2500 PPM EYES/EARS/NOSE 03-21-09 14:21 P DRIED RED MATERIAL AROUND NOSE 3814 M 2500 PPM ORAL/DENTAL 03-15-09 14:50 P DRIED CLEAR MATERIAL AROUND MOUTH 03-21-09 14:21 P DRIED RED MATERIAL AROUND MOUTH 3817 M 2500 PPM NORMAL 02-25-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 52 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3817 M 2500 PPM NORMAL 03-15-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3817 M 2500 PPM BODY/INTEGUMENT 03-03-09 14:58 P LIMBS COOL 03-16-09 15:04 P LIMBS COOL 03-19-09 15:21 P LIMBS COOL 3822 M 2500 PPM NORMAL 02-25-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 53 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3822 M 2500 PPM BODY/INTEGUMENT 03-05-09 15:45 P LIMBS COOL 03-08-09 14:39 P LIMBS COOL 03-16-09 15:05 P LIMBS COOL 03-26-09 17:21 P LIMBS COOL 3822 M 2500 PPM EYES/EARS/NOSE 03-23-09 17:27 P DRIED RED MATERIAL AROUND NOSE 3822 M 2500 PPM ORAL/DENTAL 03-23-09 17:27 P DRIED RED MATERIAL AROUND MOUTH 3831 M 2500 PPM NORMAL 03-01-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3831 M 2500 PPM BODY/INTEGUMENT 03-02-09 15:27 P LIMBS COOL 03-10-09 15:42 P LIMBS COOL 3831 M 2500 PPM EYES/EARS/NOSE 03-05-09 15:45 P DRIED RED MATERIAL AROUND NOSE 03-17-09 15:07 P DRIED RED MATERIAL AROUND NOSE 03-18-09 16:06 P DRIED RED MATERIAL AROUND NOSE 03-19-09 15:21 P DRIED RED MATERIAL AROUND NOSE 03-22-09 17:47 P DRIED RED MATERIAL AROUND NOSE 03-23-09 17:29 P DRIED RED MATERIAL AROUND NOSE 03-24-09 17:17 P DRIED RED MATERIAL AROUND RIGHT EYE 03-25-09 18:09 P DRIED RED MATERIAL AROUND NOSE 3831 M 2500 PPM ORAL/DENTAL 03-05-09 15:47 P DRIED RED MATERIAL AROUND MOUTH 03-23-09 17:29 P DRIED RED MATERIAL AROUND MOUTH 3839 M 2500 PPM NORMAL 02-25-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 54 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3839 M 2500 PPM NORMAL 02-26-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3839 M 2500 PPM BODY/INTEGUMENT 03-03-09 14:59 P LIMBS COOL 03-04-09 16:01 P LIMBS COOL 03-08-09 14:40 P LIMBS COOL 03-11-09 16:00 P LIMBS COOL 3677 F 0 PPM NORMAL 02-25-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 55 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3677 F 0 PPM NORMAL 03-12-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3686 F 0 PPM NORMAL 02-25-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 56 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3686 F 0 PPM NORMAL 03-21-09 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3691 F 0 PPM NORMAL 03-01-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3693 F 0 PPM NORMAL 03-01-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 57 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3693 F 0 PPM NORMAL 03-05-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3694 F 0 PPM NORMAL 02-25-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 58 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3694 F 0 PPM NORMAL 03-16-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3696 F 0 PPM NORMAL 02-25-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 59 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3696 F 0 PPM NORMAL 03-24-09 16:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3704 F 0 PPM NORMAL 02-25-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3714 F 0 PPM NORMAL 02-25-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 60 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3714 F 0 PPM NORMAL 03-08-09 13:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3719 F 0 PPM NORMAL 03-01-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 61 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3719 F 0 PPM NORMAL 03-22-09 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3719 F 0 PPM EYES/EARS/NOSE 03-23-09 16:50 P DRIED RED MATERIAL AROUND NOSE 3723 F 0 PPM NORMAL 03-01-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3725 F 0 PPM NORMAL 02-25-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 62 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3725 F 0 PPM NORMAL 03-03-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 13:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3733 F 0 PPM NORMAL 03-01-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 63 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3733 F 0 PPM NORMAL 03-18-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 16:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3738 F 0 PPM NORMAL 02-25-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3744 F 0 PPM NORMAL 02-25-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 64 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3744 F 0 PPM NORMAL 02-26-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3757 F 0 PPM NORMAL 02-25-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 13:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 65 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3757 F 0 PPM NORMAL 03-12-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 16:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3672 F 1000 PPM NORMAL 03-01-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 66 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3675 F 1000 PPM NORMAL 02-25-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3683 F 1000 PPM NORMAL 03-01-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 67 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3683 F 1000 PPM NORMAL 03-15-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3690 F 1000 PPM NORMAL 03-01-09 14:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 68 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3690 F 1000 PPM NORMAL 03-26-09 17:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3695 F 1000 PPM NORMAL 02-25-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3697 F 1000 PPM NORMAL 03-01-09 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 69 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3697 F 1000 PPM NORMAL 03-08-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3700 F 1000 PPM NORMAL 02-25-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 70 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3700 F 1000 PPM NORMAL 03-17-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3702 F 1000 PPM NORMAL 02-25-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3706 F 1000 PPM NORMAL 03-01-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 71 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3706 F 1000 PPM NORMAL 03-05-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3712 F 1000 PPM NORMAL 02-25-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 72 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3712 F 1000 PPM NORMAL 03-16-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3713 F 1000 PPM NORMAL 02-25-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 73 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3713 F 1000 PPM NORMAL 03-23-09 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3718 F 1000 PPM NORMAL 02-25-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3720 F 1000 PPM NORMAL 02-25-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 74 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3720 F 1000 PPM NORMAL 03-04-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3743 F 1000 PPM NORMAL 02-25-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 75 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3743 F 1000 PPM NORMAL 03-16-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 16:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3747 F 1000 PPM NORMAL 02-25-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:51 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 13:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3747 F 1000 PPM EYES/EARS/NOSE 03-23-09 17:11 P DRIED RED MATERIAL AROUND NOSE-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 76 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3674 F 1500 PPM NORMAL 02-25-09 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3674 F 1500 PPM EYES/EARS/NOSE 03-18-09 15:54 P DRIED RED MATERIAL AROUND LEFT EYE 03-19-09 15:08 P DRIED RED MATERIAL AROUND LEFT EYE 3684 F 1500 PPM NORMAL 03-01-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 77 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3684 F 1500 PPM NORMAL 03-16-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3701 F 1500 PPM NORMAL 02-25-09 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3708 F 1500 PPM NORMAL 02-25-09 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 78 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3708 F 1500 PPM NORMAL 03-01-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3708 F 1500 PPM BODY/INTEGUMENT 03-22-09 17:36 P LIMBS COOL 3711 F 1500 PPM NORMAL 02-25-09 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 79 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3711 F 1500 PPM NORMAL 03-12-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3722 F 1500 PPM NORMAL 02-25-09 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 80 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3722 F 1500 PPM NORMAL 03-22-09 17:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3724 F 1500 PPM NORMAL 03-01-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3724 F 1500 PPM BODY/INTEGUMENT 03-26-09 17:14 P LIMBS COOL 3724 F 1500 PPM EYES/EARS/NOSE 03-23-09 17:17 P DRIED RED MATERIAL AROUND RIGHT EYE 3726 F 1500 PPM NORMAL 02-25-09 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 81 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3726 F 1500 PPM NORMAL 03-05-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3726 F 1500 PPM EYES/EARS/NOSE 03-19-09 15:09 P DRIED RED MATERIAL AROUND NOSE 03-21-09 14:09 P DRIED RED MATERIAL AROUND NOSE 03-22-09 17:36 P DRIED RED MATERIAL AROUND NOSE 3727 F 1500 PPM NORMAL 02-25-09 15:13 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 82 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3727 F 1500 PPM NORMAL 03-17-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3728 F 1500 PPM NORMAL 03-01-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 83 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3729 F 1500 PPM NORMAL 03-01-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3729 F 1500 PPM EYES/EARS/NOSE 03-25-09 17:58 P WET RED MATERIAL AROUND NOSE 3729 F 1500 PPM ORAL/DENTAL 03-25-09 17:58 P WET CLEAR MATERIAL AROUND MOUTH 3731 F 1500 PPM NORMAL 02-25-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 84 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3731 F 1500 PPM NORMAL 03-10-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3734 F 1500 PPM NORMAL 02-25-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 85 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3734 F 1500 PPM NORMAL 03-22-09 17:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3748 F 1500 PPM NORMAL 03-01-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 17:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3748 F 1500 PPM EYES/EARS/NOSE 03-23-09 17:19 P DRIED RED MATERIAL AROUND NOSE 3756 F 1500 PPM NORMAL 02-25-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:12 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 86 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3756 F 1500 PPM NORMAL 03-10-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3676 F 2000 PPM NORMAL 02-25-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:36 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 87 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3676 F 2000 PPM NORMAL 03-22-09 17:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3678 F 2000 PPM NORMAL 02-25-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:46 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3678 F 2000 PPM BEHAVIOR/CNS 03-12-09 14:53 P INTERMITTENT TREMORS 3678 F 2000 PPM BODY/INTEGUMENT 03-10-09 15:37 P LIMBS COOL 03-18-09 16:00 P LIMBS COOL 03-22-09 17:42 P LIMBS COOL 3682 F 2000 PPM NORMAL 03-01-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 88 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3682 F 2000 PPM NORMAL 03-08-09 14:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3682 F 2000 PPM BODY/INTEGUMENT 03-03-09 14:53 P LIMBS COOL 3705 F 2000 PPM NORMAL 03-01-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:37 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 89 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3705 F 2000 PPM NORMAL 03-18-09 16:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3709 F 2000 PPM NORMAL 02-25-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:14 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3709 F 2000 PPM BEHAVIOR/CNS 03-12-09 14:54 P INTERMITTENT TREMORS 03-15-09 14:38 P INTERMITTENT TREMORS 3709 F 2000 PPM BODY/INTEGUMENT 03-03-09 14:53 P LIMBS COOL 03-11-09 15:55 P LIMBS COOL 03-18-09 16:01 P LIMBS COOL-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 90 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3710 F 2000 PPM NORMAL 03-01-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:33 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3710 F 2000 PPM BODY/INTEGUMENT 03-22-09 17:42 P LIMBS COOL 3710 F 2000 PPM EYES/EARS/NOSE 03-22-09 17:42 P DRIED RED MATERIAL AROUND NOSE 3710 F 2000 PPM ORAL/DENTAL 03-15-09 14:39 P DRIED RED MATERIAL AROUND MOUTH 3716 F 2000 PPM NORMAL 02-25-09 15:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 91 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3716 F 2000 PPM NORMAL 03-09-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3716 F 2000 PPM BEHAVIOR/CNS 03-12-09 14:54 P INTERMITTENT TREMORS 3732 F 2000 PPM NORMAL 02-25-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 92 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3732 F 2000 PPM BODY/INTEGUMENT 03-16-09 15:00 P LIMBS COOL 3732 F 2000 PPM EYES/EARS/NOSE 03-17-09 15:00 P DRIED RED MATERIAL AROUND NOSE 3739 F 2000 PPM NORMAL 02-25-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3740 F 2000 PPM NORMAL 03-01-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 93 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3740 F 2000 PPM NORMAL 03-09-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:38 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3745 F 2000 PPM NORMAL 02-25-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 94 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3745 F 2000 PPM NORMAL 03-18-09 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3746 F 2000 PPM NORMAL 02-25-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:34 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:15 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3749 F 2000 PPM NORMAL 03-01-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 95 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3749 F 2000 PPM NORMAL 03-05-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3749 F 2000 PPM BODY/INTEGUMENT 03-10-09 15:39 P LIMBS COOL 3749 F 2000 PPM EYES/EARS/NOSE 03-19-09 15:16 P DRIED RED MATERIAL AROUND NOSE 03-22-09 17:44 P DRIED RED MATERIAL AROUND NOSE 03-23-09 17:24 P DRIED RED MATERIAL AROUND NOSE 03-24-09 17:10 P DRIED RED MATERIAL AROUND NOSE 03-25-09 18:04 P DRIED RED MATERIAL AROUND NOSE 03-26-09 17:19 P DRIED RED MATERIAL AROUND NOSE 3749 F 2000 PPM ORAL/DENTAL 03-22-09 17:44 P DRIED RED MATERIAL AROUND MOUTH 03-24-09 17:11 P DRIED RED MATERIAL AROUND MOUTH 3751 F 2000 PPM NORMAL 02-25-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:39 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 15:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 96 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3751 F 2000 PPM NORMAL 03-15-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3751 F 2000 PPM BODY/INTEGUMENT 03-03-09 14:55 P LIMBS COOL 3754 F 2000 PPM NORMAL 02-25-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 15:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:35 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:16 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 97 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3754 F 2000 PPM NORMAL 03-26-09 17:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3754 F 2000 PPM BODY/INTEGUMENT 03-10-09 15:39 P LIMBS COOL 03-11-09 15:56 P LIMBS COOL 03-18-09 16:02 P LIMBS COOL 03-21-09 14:19 P LIMBS COOL 3673 F 2500 PPM NORMAL 02-25-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:05 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3679 F 2500 PPM NORMAL 02-25-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 98 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3679 F 2500 PPM NORMAL 03-03-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:40 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 14:59 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:52 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:47 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3679 F 2500 PPM BODY/INTEGUMENT 03-02-09 15:29 P LIMBS COOL 03-09-09 15:25 P LIMBS COOL 03-11-09 16:01 P LIMBS COOL 03-16-09 15:05 P LIMBS COOL 3679 F 2500 PPM EYES/EARS/NOSE 03-19-09 15:22 P WET RED MATERIAL AROUND NOSE 3680 F 2500 PPM NORMAL 02-25-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:17 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 99 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3680 F 2500 PPM NORMAL 03-25-09 18:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3680 F 2500 PPM BODY/INTEGUMENT 03-05-09 15:48 P LIMBS COOL 03-08-09 14:41 P LIMBS COOL 3680 F 2500 PPM EYES/EARS/NOSE 03-15-09 14:53 P DRIED RED MATERIAL AROUND NOSE 03-16-09 15:06 P DRIED RED MATERIAL AROUND NOSE 03-17-09 15:08 P DRIED RED MATERIAL AROUND NOSE 03-18-09 16:07 P DRIED RED MATERIAL AROUND NOSE 03-19-09 15:22 P DRIED RED MATERIAL AROUND NOSE 03-21-09 14:22 P DRIED RED MATERIAL AROUND NOSE 03-22-09 17:48 P DRIED RED MATERIAL AROUND NOSE 3680 F 2500 PPM ORAL/DENTAL 03-15-09 14:53 P DRIED RED MATERIAL AROUND MOUTH 03-17-09 15:08 P DRIED RED MATERIAL AROUND MOUTH 03-18-09 16:07 P DRIED RED MATERIAL AROUND MOUTH 03-19-09 15:22 P DRIED RED MATERIAL AROUND MOUTH 03-21-09 14:22 P DRIED RED MATERIAL AROUND MOUTH 03-22-09 17:48 P DRIED RED MATERIAL AROUND MOUTH 3685 F 2500 PPM NORMAL 02-25-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:25 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:53 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 100 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3685 F 2500 PPM NORMAL 03-17-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3685 F 2500 PPM BODY/INTEGUMENT 03-04-09 16:02 P LIMBS COOL 03-26-09 17:21 P LIMBS COOL 3688 F 2500 PPM NORMAL 03-01-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:29 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:21 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3688 F 2500 PPM BODY/INTEGUMENT 03-03-09 15:00 P LIMBS COOL 03-16-09 15:06 P LIMBS COOL-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 101 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3688 F 2500 PPM BODY/INTEGUMENT 03-22-09 17:48 P LIMBS COOL 3689 F 2500 PPM NORMAL 02-25-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:54 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3689 F 2500 PPM BEHAVIOR/CNS 03-12-09 15:00 P INTERMITTENT TREMORS 3689 F 2500 PPM EYES/EARS/NOSE 03-23-09 17:30 P DRIED RED MATERIAL AROUND NOSE 3698 F 2500 PPM NORMAL 02-25-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:41 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 102 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3698 F 2500 PPM NORMAL 03-09-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:55 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:06 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3698 F 2500 PPM BODY/INTEGUMENT 03-18-09 16:08 P LIMBS COOL 3703 F 2500 PPM NORMAL 03-01-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 103 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3703 F 2500 PPM NORMAL 03-25-09 18:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3717 F 2500 PPM NORMAL 03-01-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:26 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:48 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3721 F 2500 PPM NORMAL 02-25-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 104 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3721 F 2500 PPM NORMAL 03-10-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:56 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:30 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:18 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3721 F 2500 PPM BODY/INTEGUMENT 03-03-09 15:01 P LIMBS COOL 03-08-09 14:42 P LIMBS COOL 3730 F 2500 PPM NORMAL 02-25-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 105 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3730 F 2500 PPM NORMAL 03-18-09 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3742 F 2500 PPM NORMAL 02-25-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:42 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:07 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:09 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3742 F 2500 PPM BEHAVIOR/CNS 03-12-09 15:01 P INTERMITTENT TREMORS 3742 F 2500 PPM EYES/EARS/NOSE 03-15-09 14:58 P DRIED RED MATERIAL AROUND RIGHT EYE 03-19-09 15:24 P DRIED RED MATERIAL AROUND RIGHT EYE 03-21-09 14:24 P DRIED RED MATERIAL AROUND RIGHT EYE 3753 F 2500 PPM NORMAL 02-25-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 02-26-09 14:57 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-01-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 106 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3753 F 2500 PPM NORMAL 03-05-09 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 14:58 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-21-09 14:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:19 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-25-09 18:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:22 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3753 F 2500 PPM BODY/INTEGUMENT 03-02-09 15:32 P LIMBS COOL 03-03-09 15:02 P LIMBS COOL 03-08-09 14:43 P LIMBS COOL 03-17-09 15:10 P LIMBS COOL 03-18-09 16:09 P LIMBS COOL 3755 F 2500 PPM NORMAL 03-01-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:27 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:44 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:03 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 107 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3755 F 2500 PPM NORMAL 03-17-09 15:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-22-09 17:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3755 F 2500 PPM BODY/INTEGUMENT 03-16-09 15:08 P LIMBS COOL 03-18-09 16:09 P LIMBS COOL 03-19-09 15:24 P LIMBS COOL 3755 F 2500 PPM EYES/EARS/NOSE 03-15-09 14:59 P DRIED RED MATERIAL AROUND NOSE 03-19-09 15:24 P DRIED RED MATERIAL AROUND NOSE 03-23-09 17:31 P DRIED RED MATERIAL AROUND NOSE 03-24-09 17:19 P DRIED RED MATERIAL AROUND NOSE 03-25-09 18:11 P DRIED RED MATERIAL AROUND NOSE 03-26-09 17:22 P DRIED RED MATERIAL AROUND NOSE 3755 F 2500 PPM ORAL/DENTAL 03-26-09 17:23 P DRIED RED MATERIAL AROUND MOUTH 3758 F 2500 PPM NORMAL 03-01-09 14:50 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-02-09 15:32 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-03-09 15:02 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-04-09 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-05-09 15:49 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-08-09 14:43 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-09-09 15:28 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-10-09 15:45 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-11-09 16:04 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-12-09 15:01 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-15-09 15:00 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-16-09 15:08 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-17-09 15:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-18-09 16:10 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-19-09 15:24 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-23-09 17:31 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-24-09 17:20 P NO SIGNIFICANT CLINICAL OBSERVATIONS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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 TABLE A4 (0-1 HOUR FOLLOWING EXPOSURE - COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 108 INDIVIDUAL CLINICAL OBSERVATIONS TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3758 F 2500 PPM NORMAL 03-25-09 18:11 P NO SIGNIFICANT CLINICAL OBSERVATIONS 03-26-09 17:23 P NO SIGNIFICANT CLINICAL OBSERVATIONS 3758 F 2500 PPM EYES/EARS/NOSE 03-22-09 17:49 P DRIED RED MATERIAL AROUND NOSE-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PCRDv4.11 05/11/2009

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 TABLE A5 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL BODY WEIGHTS [G] MALE GROUP: 0 PPM PRIOR TO WEEK -1 0 1 2 3 EUTHANASIA----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3774 228. 293. 324. 356. 392. 408. 3776 197. 251. 276. 292. 319. 335. 3780 211. 277. 315. 352. 397. 417. 3787 206. 279. 315. 356. 386. 412. 3789 280. 313. 332. 351. 371. 373. 3790 281. 311. 331. 355. 379. 382. 3791 257. 282. 303. 330. 354. 364. 3802 309. 349. 382. 414. 436. 445. 3803 199. 254. 269. 286. 297. 307. 3811 262. 288. 308. 335. 363. 371. 3826 194. 248. 275. 294. 314. 333. 3828 201. 267. 301. 330. 366. 382. 3832 220. 297. 341. 386. 417. 443. 3837 217. 277. 315. 340. 370. 388. 3843 208. 275. 316. 350. 383. 408.MEAN 231. 284. 314. 342. 370. 385.S.D. 36.8 26.5 28.5 34.0 37.5 39.5S.E. 9.5 6.8 7.4 8.8 9.7 10.2 N 15 15 15 15 15 15

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 TABLE A5 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL BODY WEIGHTS [G] MALE GROUP: 1000 PPM PRIOR TO WEEK -1 0 1 2 3 EUTHANASIA----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3764 278. 309. 343. 377. 409. 418. 3769 200. 250. 279. 307. 329. 348. 3772 223. 281. 315. 353. 384. 399. 3773 231. 304. 339. 373. 396. 419. 3781 203. 264. 302. 328. 361. 378. 3800 210. 283. 317. 355. 405. 431. 3801 265. 301. 323. 362. 387. 399. 3805 204. 264. 294. 323. 351. 377. 3806 262. 308. 345. 382. 417. 424. 3816 203. 269. 299. 329. 356. 374. 3818 211. 273. 311. 349. 388. 411. 3824 287. 319. 351. 386. 407. 422. 3840 281. 325. 365. 393. 419. 423. 3845 196. 259. 293. 322. 345. 361. 3846 218. 285. 324. 364. 399. 417.MEAN 231. 286. 320. 354. 384. 400.S.D. 33.3 23.4 24.6 26.6 28.3 26.1S.E. 8.6 6.0 6.4 6.9 7.3 6.7 N 15 15 15 15 15 15

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 TABLE A5 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL BODY WEIGHTS [G] MALE GROUP: 1500 PPM PRIOR TO WEEK -1 0 1 2 3 EUTHANASIA----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3762 222. 284. 312. 359. 399. 431. 3765 277. 301. 331. 358. 387. 391. 3766 283. 317. 352. 393. 418. 422. 3768 203. 267. 302. 344. 381. 407. 3777 265. 292. 326. 352. 377. 382. 3778 283. 316. 349. 390. 428. 430. 3786 200. 255. 286. 317. 348. 368. 3788 203. 277. 315. 340. 375. 384. 3798 258. 269. 278. 290. 313. 313. 3813 206. 268. 289. 317. 340. 354. 3819 226. 296. 321. 353. 395. 418. 3825 219. 300. 322. 362. 396. 434. 3833 211. 280. 303. 330. 359. 374. 3841 194. 255. 284. 318. 346. 386. 3842 213. 282. 310. 351. 387. 418.MEAN 231. 284. 312. 345. 377. 394.S.D. 32.6 19.6 22.4 27.7 30.8 33.7S.E. 8.4 5.1 5.8 7.1 7.9 8.7 N 15 15 15 15 15 15

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 TABLE A5 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL BODY WEIGHTS [G] MALE GROUP: 2000 PPM PRIOR TO WEEK -1 0 1 2 3 EUTHANASIA----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3760 202. 266. 289. 321. 356. 351. 3770 197. 255. 277. 305. 331. 266. 3779 218. 260. 277. 297. 331. 356. 3782 213. 275. 312. 346. 379. 406. 3784 203. 262. 280. 318. 357. 379. 3792 320. 357. 405. 458. 489. 505. 3793 220. 279. 296. 320. 346. 367. 3794 200. 254. 276. 297. 320. 337. 3799 267. 285. 310. 342. 373. 376. 3809 247. 268. 291. 325. 354. 348. 3812 275. 301. 335. 362. 392. 404. 3815 255. 277. 296. 314. 334. 333. 3820 211. 279. 310. 345. 382. 405. 3821 217. 279. 306. 336. 374. 395. 3838 223. 285. 313. 348. 382. 406.MEAN 231. 279. 305. 336. 367. 376.S.D. 34.8 25.1 32.4 39.0 40.5 52.0S.E. 9.0 6.5 8.4 10.1 10.4 13.4 N 15 15 15 15 15 15

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 TABLE A5 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL BODY WEIGHTS [G] MALE GROUP: 2500 PPM PRIOR TO WEEK -1 0 1 2 3 EUTHANASIA----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3763 195. 257. 282. 311. 346. 363. 3767 229. 307. 336. 372. 410. 422. 3771 225. 290. 321. 352. 388. 406. 3775 200. 255. 269. 297. 326. 350. 3783 280. 316. 342. 372. 395. 397. 3785 292. 312. 346. 382. 401. 409. 3795 211. 272. 278. 298. 328. 357. 3804 201. 261. 269. 291. 316. 334. 3807 291. 313. 334. 366. 386. 390. 3810 254. 276. 305. 331. 360. 366. 3814 217. 280. 291. 322. 356. 385. 3817 221. 287. 303. 331. 368. 399. 3822 207. 268. 279. 314. 347. 369. 3831 249. 274. 296. 325. 329. 336. 3839 206. 271. 296. 323. 358. 375.MEAN 232. 283. 303. 332. 361. 377.S.D. 33.4 20.8 26.7 29.7 29.7 26.8S.E. 8.6 5.4 6.9 7.7 7.7 6.9 N 15 15 15 15 15 15

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 TABLE A5 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL BODY WEIGHTS [G] FEMALE GROUP: 0 PPM PRIOR TO WEEK -1 0 1 2 3 EUTHANASIA----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3677 173. 209. 238. 251. 265. 277. 3686 148. 168. 195. 214. 228. 241. 3691 206. 244. 269. 296. 323. 319. 3693 197. 217. 233. 245. 271. 266. 3694 169. 190. 208. 218. 235. 249. 3696 170. 193. 215. 230. 238. 252. 3704 165. 183. 199. 206. 219. 227. 3714 160. 188. 210. 225. 230. 230. 3719 199. 214. 228. 235. 250. 251. 3723 183. 207. 228. 242. 245. 259. 3725 155. 177. 189. 196. 225. 240. 3733 235. 247. 280. 294. 320. 325. 3738 165. 191. 210. 226. 234. 236. 3744 163. 197. 217. 228. 233. 238. 3757 174. 204. 233. 255. 266. 274.MEAN 177. 202. 223. 237. 252. 259.S.D. 22.9 22.3 25.4 28.4 32.2 29.6S.E. 5.9 5.8 6.6 7.3 8.3 7.6 N 15 15 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A5 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL BODY WEIGHTS [G] FEMALE GROUP: 1000 PPM PRIOR TO WEEK -1 0 1 2 3 EUTHANASIA----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3672 188. 196. 218. 233. 239. 251. 3675 153. 186. 205. 220. 228. 224. 3683 197. 215. 229. 247. 258. 266. 3690 188. 201. 212. 216. 241. 238. 3695 167. 194. 217. 228. 248. 263. 3697 195. 213. 234. 259. 276. 282. 3700 177. 197. 218. 231. 252. 263. 3702 192. 198. 223. 250. 260. 265. 3706 199. 207. 220. 231. 235. 243. 3712 156. 183. 207. 230. 245. 255. 3713 174. 210. 224. 234. 259. 262. 3718 173. 178. 204. 216. 237. 244. 3720 162. 186. 198. 223. 248. 255. 3743 164. 198. 220. 238. 243. 252. 3747 177. 219. 243. 266. 308. 317.MEAN 177. 199. 218. 235. 252. 259.S.D. 15.1 12.3 11.9 14.9 19.6 21.2S.E. 3.9 3.2 3.1 3.9 5.1 5.5 N 15 15 15 15 15 15

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 TABLE A5 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL BODY WEIGHTS [G] FEMALE GROUP: 1500 PPM PRIOR TO WEEK -1 0 1 2 3 EUTHANASIA----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3674 159. 187. 208. 210. 242. 248. 3684 218. 231. 249. 258. 274. 273. 3701 151. 176. 187. 209. 226. 232. 3708 178. 203. 221. 240. 243. 260. 3711 177. 207. 230. 253. 270. 283. 3722 163. 201. 214. 238. 250. 268. 3724 219. 229. 251. 274. 279. 286. 3726 167. 187. 209. 230. 240. 264. 3727 173. 204. 229. 249. 258. 271. 3728 203. 215. 235. 256. 272. 270. 3729 203. 221. 243. 261. 284. 277. 3731 164. 181. 204. 227. 243. 254. 3734 155. 178. 184. 202. 219. 225. 3748 202. 221. 240. 242. 267. 260. 3756 159. 164. 190. 204. 222. 239.MEAN 179. 200. 220. 237. 253. 261.S.D. 23.3 20.8 22.3 22.6 21.2 18.1S.E. 6.0 5.4 5.8 5.8 5.5 4.7 N 15 15 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A5 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL BODY WEIGHTS [G] FEMALE GROUP: 2000 PPM PRIOR TO WEEK -1 0 1 2 3 EUTHANASIA----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3676 184. 211. 232. 254. 262. 284. 3678 162. 193. 206. 227. 249. 259. 3682 201. 212. 237. 255. 259. 269. 3705 176. 187. 200. 216. 224. 225. 3709 168. 199. 219. 234. 259. 274. 3710 200. 216. 227. 246. 257. 256. 3716 180. 205. 233. 244. 272. 289. 3732 155. 181. 194. 202. 230. 239. 3739 173. 198. 212. 227. 248. 254. 3740 196. 200. 235. 251. 260. 265. 3745 161. 198. 214. 237. 251. 261. 3746 159. 175. 194. 212. 237. 252. 3749 203. 218. 241. 259. 268. 274. 3751 165. 198. 224. 240. 260. 276. 3754 172. 206. 221. 251. 269. 274.MEAN 177. 200. 219. 237. 254. 263.S.D. 16.4 12.3 15.5 17.2 14.1 16.9S.E. 4.2 3.2 4.0 4.4 3.6 4.4 N 15 15 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A5 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL BODY WEIGHTS [G] FEMALE GROUP: 2500 PPM PRIOR TO WEEK -1 0 1 2 3 EUTHANASIA----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3673 171. 196. 221. 242. 253. 272. 3679 173. 197. 214. 232. 248. 258. 3680 180. 209. 230. 254. 270. 291. 3685 161. 178. 197. 206. 221. 234. 3688 212. 223. 251. 266. 274. 276. 3689 167. 202. 218. 242. 253. 254. 3698 169. 208. 227. 237. 262. 275. 3703 187. 188. 208. 223. 233. 231. 3717 181. 196. 222. 222. 224. 231. 3721 154. 175. 192. 202. 218. 226. 3730 176. 194. 220. 244. 257. 276. 3742 180. 211. 230. 245. 260. 282. 3753 163. 186. 198. 217. 229. 243. 3755 181. 198. 240. 249. 264. 267. 3758 200. 207. 224. 241. 259. 260.MEAN 177. 198. 219. 235. 248. 258.S.D. 14.9 12.8 16.1 17.8 18.5 21.0S.E. 3.8 3.3 4.1 4.6 4.8 5.4 N 15 15 15 15 15 15 PBFTSv4.45 06/15/2009 R:07/15/2009

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A6 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL BODY WEIGHT CHANGES [G] MALE GROUP: 0 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3 3 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3774 65. 31. 32. 36. 16. 3776 54. 25. 16. 27. 16. 3780 66. 38. 37. 45. 20. 3787 73. 36. 41. 30. 26. 3789 33. 19. 19. 20. 2. 3790 30. 20. 24. 24. 3. 3791 25. 21. 27. 24. 10. 3802 40. 33. 32. 22. 9. 3803 55. 15. 17. 11. 10. 3811 26. 20. 27. 28. 8. 3826 54. 27. 19. 20. 19. 3828 66. 34. 29. 36. 16. 3832 77. 44. 45. 31. 26. 3837 60. 38. 25. 30. 18. 3843 67. 41. 34. 33. 25.MEAN 53. 29. 28. 28. 15.S.D. 17.6 9.1 8.7 8.2 7.8S.E. 4.5 2.4 2.2 2.1 2.0 N 15 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A6 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL BODY WEIGHT CHANGES [G] MALE GROUP: 1000 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3 3 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3764 31. 34. 34. 32. 9. 3769 50. 29. 28. 22. 19. 3772 58. 34. 38. 31. 15. 3773 73. 35. 34. 23. 23. 3781 61. 38. 26. 33. 17. 3800 73. 34. 38. 50. 26. 3801 36. 22. 39. 25. 12. 3805 60. 30. 29. 28. 26. 3806 46. 37. 37. 35. 7. 3816 66. 30. 30. 27. 18. 3818 62. 38. 38. 39. 23. 3824 32. 32. 35. 21. 15. 3840 44. 40. 28. 26. 4. 3845 63. 34. 29. 23. 16. 3846 67. 39. 40. 35. 18.MEAN 55. 34. 34. 30. 17.S.D. 14.1 4.7 4.8 7.8 6.6S.E. 3.6 1.2 1.2 2.0 1.7 N 15 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A6 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL BODY WEIGHT CHANGES [G] MALE GROUP: 1500 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3 3 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3762 62. 28. 47. 40. 32. 3765 24. 30. 27. 29. 4. 3766 34. 35. 41. 25. 4. 3768 64. 35. 42. 37. 26. 3777 27. 34. 26. 25. 5. 3778 33. 33. 41. 38. 2. 3786 55. 31. 31. 31. 20. 3788 74. 38. 25. 35. 9. 3798 11. 9. 12. 23. 0. 3813 62. 21. 28. 23. 14. 3819 70. 25. 32. 42. 23. 3825 81. 22. 40. 34. 38. 3833 69. 23. 27. 29. 15. 3841 61. 29. 34. 28. 40. 3842 69. 28. 41. 36. 31.MEAN 53. 28. 33. 32. 18.S.D. 21.4 7.3 9.2 6.3 13.6S.E. 5.5 1.9 2.4 1.6 3.5 N 15 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A6 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL BODY WEIGHT CHANGES [G] MALE GROUP: 2000 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3 3 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3760 64. 23. 32. 35. -5. 3770 58. 22. 28. 26. -65. 3779 42. 17. 20. 34. 25. 3782 62. 37. 34. 33. 27. 3784 59. 18. 38. 39. 22. 3792 37. 48. 53. 31. 16. 3793 59. 17. 24. 26. 21. 3794 54. 22. 21. 23. 17. 3799 18. 25. 32. 31. 3. 3809 21. 23. 34. 29. -6. 3812 26. 34. 27. 30. 12. 3815 22. 19. 18. 20. -1. 3820 68. 31. 35. 37. 23. 3821 62. 27. 30. 38. 21. 3838 62. 28. 35. 34. 24.MEAN 48. 26. 31. 31. 9.S.D. 18.1 8.6 8.7 5.5 23.3S.E. 4.7 2.2 2.2 1.4 6.0 N 15 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A6 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL BODY WEIGHT CHANGES [G] MALE GROUP: 2500 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3 3 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3763 62. 25. 29. 35. 17. 3767 78. 29. 36. 38. 12. 3771 65. 31. 31. 36. 18. 3775 55. 14. 28. 29. 24. 3783 36. 26. 30. 23. 2. 3785 20. 34. 36. 19. 8. 3795 61. 6. 20. 30. 29. 3804 60. 8. 22. 25. 18. 3807 22. 21. 32. 20. 4. 3810 22. 29. 26. 29. 6. 3814 63. 11. 31. 34. 29. 3817 66. 16. 28. 37. 31. 3822 61. 11. 35. 33. 22. 3831 25. 22. 29. 4. 7. 3839 65. 25. 27. 35. 17.MEAN 51. 21. 29. 28. 16.S.D. 19.7 8.9 4.6 9.1 9.5S.E. 5.1 2.3 1.2 2.4 2.5 N 15 15 15 15 15

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A6 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL BODY WEIGHT CHANGES [G] FEMALE GROUP: 0 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3 3 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3677 36. 29. 13. 14. 12. 3686 20. 27. 19. 14. 13. 3691 38. 25. 27. 27. -4. 3693 20. 16. 12. 26. -5. 3694 21. 18. 10. 17. 14. 3696 23. 22. 15. 8. 14. 3704 18. 16. 7. 13. 8. 3714 28. 22. 15. 5. 0. 3719 15. 14. 7. 15. 1. 3723 24. 21. 14. 3. 14. 3725 22. 12. 7. 29. 15. 3733 12. 33. 14. 26. 5. 3738 26. 19. 16. 8. 2. 3744 34. 20. 11. 5. 5. 3757 30. 29. 22. 11. 8.MEAN 24. 22. 14. 15. 7.S.D. 7.6 6.1 5.6 8.7 6.8S.E. 2.0 1.6 1.4 2.2 1.8 N 15 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A6 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL BODY WEIGHT CHANGES [G] FEMALE GROUP: 1000 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3 3 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3672 8. 22. 15. 6. 12. 3675 33. 19. 15. 8. -4. 3683 18. 14. 18. 11. 8. 3690 13. 11. 4. 25. -3. 3695 27. 23. 11. 20. 15. 3697 18. 21. 25. 17. 6. 3700 20. 21. 13. 21. 11. 3702 6. 25. 27. 10. 5. 3706 8. 13. 11. 4. 8. 3712 27. 24. 23. 15. 10. 3713 36. 14. 10. 25. 3. 3718 5. 26. 12. 21. 7. 3720 24. 12. 25. 25. 7. 3743 34. 22. 18. 5. 9. 3747 42. 24. 23. 42. 9.MEAN 21. 19. 17. 17. 7.S.D. 11.8 5.2 6.8 10.2 5.1S.E. 3.1 1.3 1.7 2.6 1.3 N 15 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A6 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL BODY WEIGHT CHANGES [G] FEMALE GROUP: 1500 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3 3 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3674 28. 21. 2. 32. 6. 3684 13. 18. 9. 16. -1. 3701 25. 11. 22. 17. 6. 3708 25. 18. 19. 3. 17. 3711 30. 23. 23. 17. 13. 3722 38. 13. 24. 12. 18. 3724 10. 22. 23. 5. 7. 3726 20. 22. 21. 10. 24. 3727 31. 25. 20. 9. 13. 3728 12. 20. 21. 16. -2. 3729 18. 22. 18. 23. -7. 3731 17. 23. 23. 16. 11. 3734 23. 6. 18. 17. 6. 3748 19. 19. 2. 25. -7. 3756 5. 26. 14. 18. 17.MEAN 21. 19. 17. 16. 8.S.D. 8.9 5.5 7.3 7.5 9.3S.E. 2.3 1.4 1.9 1.9 2.4 N 15 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A6 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL BODY WEIGHT CHANGES [G] FEMALE GROUP: 2000 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3 3 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3676 27. 21. 22. 8. 22. 3678 31. 13. 21. 22. 10. 3682 11. 25. 18. 4. 10. 3705 11. 13. 16. 8. 1. 3709 31. 20. 15. 25. 15. 3710 16. 11. 19. 11. -1. 3716 25. 28. 11. 28. 17. 3732 26. 13. 8. 28. 9. 3739 25. 14. 15. 21. 6. 3740 4. 35. 16. 9. 5. 3745 37. 16. 23. 14. 10. 3746 16. 19. 18. 25. 15. 3749 15. 23. 18. 9. 6. 3751 33. 26. 16. 20. 16. 3754 34. 15. 30. 18. 5.MEAN 23. 19. 18. 17. 10.S.D. 10.0 6.9 5.2 8.1 6.3S.E. 2.6 1.8 1.3 2.1 1.6 N 15 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A6 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL BODY WEIGHT CHANGES [G] FEMALE GROUP: 2500 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3 3 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3673 25. 25. 21. 11. 19. 3679 24. 17. 18. 16. 10. 3680 29. 21. 24. 16. 21. 3685 17. 19. 9. 15. 13. 3688 11. 28. 15. 8. 2. 3689 35. 16. 24. 11. 1. 3698 39. 19. 10. 25. 13. 3703 1. 20. 15. 10. -2. 3717 15. 26. 0. 2. 7. 3721 21. 17. 10. 16. 8. 3730 18. 26. 24. 13. 19. 3742 31. 19. 15. 15. 22. 3753 23. 12. 19. 12. 14. 3755 17. 42. 9. 15. 3. 3758 7. 17. 17. 18. 1.MEAN 21. 22. 15. 14. 10.S.D. 10.3 7.2 6.8 5.1 8.0S.E. 2.7 1.8 1.8 1.3 2.1 N 15 15 15 15 15 PBFTSv4.45 06/15/2009 R:06/18/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A7 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL CUMULATIVE BODY WEIGHT CHANGES [G] MALE GROUP: 0 PPM WEEK 0 TO 1 0 TO 2 0 TO 3 0 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3774 31. 63. 99. 115. 3776 25. 41. 68. 84. 3780 38. 75. 120. 140. 3787 36. 77. 107. 133. 3789 19. 38. 58. 60. 3790 20. 44. 68. 71. 3791 21. 48. 72. 82. 3802 33. 65. 87. 96. 3803 15. 32. 43. 53. 3811 20. 47. 75. 83. 3826 27. 46. 66. 85. 3828 34. 63. 99. 115. 3832 44. 89. 120. 146. 3837 38. 63. 93. 111. 3843 41. 75. 108. 133.MEAN 29. 58. 86. 100.S.D. 9.1 16.8 23.3 29.5S.E. 2.4 4.3 6.0 7.6 N 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A7 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL CUMULATIVE BODY WEIGHT CHANGES [G] MALE GROUP: 1000 PPM WEEK 0 TO 1 0 TO 2 0 TO 3 0 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3764 34. 68. 100. 109. 3769 29. 57. 79. 98. 3772 34. 72. 103. 118. 3773 35. 69. 92. 115. 3781 38. 64. 97. 114. 3800 34. 72. 122. 148. 3801 22. 61. 86. 98. 3805 30. 59. 87. 113. 3806 37. 74. 109. 116. 3816 30. 60. 87. 105. 3818 38. 76. 115. 138. 3824 32. 67. 88. 103. 3840 40. 68. 94. 98. 3845 34. 63. 86. 102. 3846 39. 79. 114. 132.MEAN 34. 67. 97. 114.S.D. 4.7 6.6 12.8 15.2S.E. 1.2 1.7 3.3 3.9 N 15 15 15 15

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A7 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL CUMULATIVE BODY WEIGHT CHANGES [G] MALE GROUP: 1500 PPM WEEK 0 TO 1 0 TO 2 0 TO 3 0 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3762 28. 75. 115. 147. 3765 30. 57. 86. 90. 3766 35. 76. 101. 105. 3768 35. 77. 114. 140. 3777 34. 60. 85. 90. 3778 33. 74. 112. 114. 3786 31. 62. 93. 113. 3788 38. 63. 98. 107. 3798 9. 21. 44. 44. 3813 21. 49. 72. 86. 3819 25. 57. 99. 122. 3825 22. 62. 96. 134. 3833 23. 50. 79. 94. 3841 29. 63. 91. 131. 3842 28. 69. 105. 136.MEAN 28. 61. 93. 110.S.D. 7.3 14.2 18.4 26.9S.E. 1.9 3.7 4.7 7.0 N 15 15 15 15

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A7 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL CUMULATIVE BODY WEIGHT CHANGES [G] MALE GROUP: 2000 PPM WEEK 0 TO 1 0 TO 2 0 TO 3 0 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3760 23. 55. 90. 85. 3770 22. 50. 76. 11. 3779 17. 37. 71. 96. 3782 37. 71. 104. 131. 3784 18. 56. 95. 117. 3792 48. 101. 132. 148. 3793 17. 41. 67. 88. 3794 22. 43. 66. 83. 3799 25. 57. 88. 91. 3809 23. 57. 86. 80. 3812 34. 61. 91. 103. 3815 19. 37. 57. 56. 3820 31. 66. 103. 126. 3821 27. 57. 95. 116. 3838 28. 63. 97. 121.MEAN 26. 57. 88. 97.S.D. 8.6 16.0 18.8 33.6S.E. 2.2 4.1 4.8 8.7 N 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A7 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL CUMULATIVE BODY WEIGHT CHANGES [G] MALE GROUP: 2500 PPM WEEK 0 TO 1 0 TO 2 0 TO 3 0 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3763 25. 54. 89. 106. 3767 29. 65. 103. 115. 3771 31. 62. 98. 116. 3775 14. 42. 71. 95. 3783 26. 56. 79. 81. 3785 34. 70. 89. 97. 3795 6. 26. 56. 85. 3804 8. 30. 55. 73. 3807 21. 53. 73. 77. 3810 29. 55. 84. 90. 3814 11. 42. 76. 105. 3817 16. 44. 81. 112. 3822 11. 46. 79. 101. 3831 22. 51. 55. 62. 3839 25. 52. 87. 104.MEAN 21. 50. 78. 95.S.D. 8.9 12.0 14.7 16.2S.E. 2.3 3.1 3.8 4.2 N 15 15 15 15

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A7 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL CUMULATIVE BODY WEIGHT CHANGES [G] FEMALE GROUP: 0 PPM WEEK 0 TO 1 0 TO 2 0 TO 3 0 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3677 29. 42. 56. 68. 3686 27. 46. 60. 73. 3691 25. 52. 79. 75. 3693 16. 28. 54. 49. 3694 18. 28. 45. 59. 3696 22. 37. 45. 59. 3704 16. 23. 36. 44. 3714 22. 37. 42. 42. 3719 14. 21. 36. 37. 3723 21. 35. 38. 52. 3725 12. 19. 48. 63. 3733 33. 47. 73. 78. 3738 19. 35. 43. 45. 3744 20. 31. 36. 41. 3757 29. 51. 62. 70.MEAN 22. 35. 50. 57.S.D. 6.1 10.6 13.5 13.7S.E. 1.6 2.7 3.5 3.5 N 15 15 15 15

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A7 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL CUMULATIVE BODY WEIGHT CHANGES [G] FEMALE GROUP: 1000 PPM WEEK 0 TO 1 0 TO 2 0 TO 3 0 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3672 22. 37. 43. 55. 3675 19. 34. 42. 38. 3683 14. 32. 43. 51. 3690 11. 15. 40. 37. 3695 23. 34. 54. 69. 3697 21. 46. 63. 69. 3700 21. 34. 55. 66. 3702 25. 52. 62. 67. 3706 13. 24. 28. 36. 3712 24. 47. 62. 72. 3713 14. 24. 49. 52. 3718 26. 38. 59. 66. 3720 12. 37. 62. 69. 3743 22. 40. 45. 54. 3747 24. 47. 89. 98.MEAN 19. 36. 53. 60.S.D. 5.2 9.9 14.3 16.4S.E. 1.3 2.6 3.7 4.2 N 15 15 15 15

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A7 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL CUMULATIVE BODY WEIGHT CHANGES [G] FEMALE GROUP: 1500 PPM WEEK 0 TO 1 0 TO 2 0 TO 3 0 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3674 21. 23. 55. 61. 3684 18. 27. 43. 42. 3701 11. 33. 50. 56. 3708 18. 37. 40. 57. 3711 23. 46. 63. 76. 3722 13. 37. 49. 67. 3724 22. 45. 50. 57. 3726 22. 43. 53. 77. 3727 25. 45. 54. 67. 3728 20. 41. 57. 55. 3729 22. 40. 63. 56. 3731 23. 46. 62. 73. 3734 6. 24. 41. 47. 3748 19. 21. 46. 39. 3756 26. 40. 58. 75.MEAN 19. 37. 52. 60.S.D. 5.5 8.8 7.6 12.1S.E. 1.4 2.3 2.0 3.1 N 15 15 15 15

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A7 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL CUMULATIVE BODY WEIGHT CHANGES [G] FEMALE GROUP: 2000 PPM WEEK 0 TO 1 0 TO 2 0 TO 3 0 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3676 21. 43. 51. 73. 3678 13. 34. 56. 66. 3682 25. 43. 47. 57. 3705 13. 29. 37. 38. 3709 20. 35. 60. 75. 3710 11. 30. 41. 40. 3716 28. 39. 67. 84. 3732 13. 21. 49. 58. 3739 14. 29. 50. 56. 3740 35. 51. 60. 65. 3745 16. 39. 53. 63. 3746 19. 37. 62. 77. 3749 23. 41. 50. 56. 3751 26. 42. 62. 78. 3754 15. 45. 63. 68.MEAN 19. 37. 54. 64.S.D. 6.9 7.7 8.6 13.2S.E. 1.8 2.0 2.2 3.4 N 15 15 15 15

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A7 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL CUMULATIVE BODY WEIGHT CHANGES [G] FEMALE GROUP: 2500 PPM WEEK 0 TO 1 0 TO 2 0 TO 3 0 TO PRIOR TO NECROPSY----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3673 25. 46. 57. 76. 3679 17. 35. 51. 61. 3680 21. 45. 61. 82. 3685 19. 28. 43. 56. 3688 28. 43. 51. 53. 3689 16. 40. 51. 52. 3698 19. 29. 54. 67. 3703 20. 35. 45. 43. 3717 26. 26. 28. 35. 3721 17. 27. 43. 51. 3730 26. 50. 63. 82. 3742 19. 34. 49. 71. 3753 12. 31. 43. 57. 3755 42. 51. 66. 69. 3758 17. 34. 52. 53.MEAN 22. 37. 50. 61.S.D. 7.2 8.4 9.5 13.8S.E. 1.8 2.2 2.5 3.6 N 15 15 15 15 PBFTSv4.45 06/15/2009 R:06/18/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A8 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY] MALE GROUP: 0 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3774 23. 23. 23. 24. 3776 22. 20. 20. 21. 3780 24. 23. 24. 28. 3787 24. 24. 26. 27. 3789 24. 23. 24. 25. 3790 22. 23. 25. 24. 3791 21. 20. 22. 21. 3802 25. 24. 25. 26. 3803 20. 18. 17. 17. 3811 23. 22. 23. 23. 3826 22. 22. 21. 21. 3828 24. 23. 21. 23. 3832 25. 24. 25. 26. 3837 24. 22. 22. 23. 3843 23. 23. 24. 24.MEAN 23. 22. 23. 24.S.D. 1.4 1.7 2.4 2.8S.E. 0.4 0.4 0.6 0.7 N 15 15 15 15

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A8 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY] MALE GROUP: 1000 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3764 22. 23. 24. 24. 3769 20. 19. 20. 21. 3772 24. 23. 25. 26. 3773 26. 24. 25. NA 3781 23. 24. 23. 24. 3800 25. 24. 25. 27. 3801 21. 21. 22. 23. 3805 21. 20. 21. 21. 3806 24. 24. 26. 26. 3816 21. 21. 22. 23. 3818 23. 30. 25. 26. 3824 23. 23. 25. 25. 3840 24. 24. 23. 24. 3845 20. 21. 22. 21. 3846 25. 24. 26. 26.MEAN 23. 23. 24. 24.S.D. 1.9 2.6 1.9 2.1S.E. 0.5 0.7 0.5 0.5 N 15 15 15 14NA = NOT APPLICABLE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A8 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY] MALE GROUP: 1500 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3762 23. 21. 25. 26. 3765 21. 21. 22. 23. 3766 23. 24. 26. 26. 3768 22. 21. 24. 26. 3777 23. 25. 25. 25. 3778 22. 23. 25. 26. 3786 22. 22. 22. 23. 3788 24. 24. 24. 26. 3798 21. 18. 19. 20. 3813 21. 21. 21. 21. 3819 24. 21. 23. 25. 3825 27. 23. 23. 26. 3833 24. 20. 21. 23. 3841 22. 19. 21. 23. 3842 23. 22. 24. 26.MEAN 23. 22. 23. 24.S.D. 1.6 1.9 2.0 2.0S.E. 0.4 0.5 0.5 0.5 N 15 15 15 15

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A8 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY] MALE GROUP: 2000 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3760 21. 18. 21. 22. 3770 22. 19. 21. 22. 3779 21. 19. 20. 21. 3782 23. 22. 24. 25. 3784 22. 20. 22. 26. 3792 27. 27. 30. 30. 3793 23. 20. 22. 23. 3794 21. 19. 20. 19. 3799 20. 21. 23. 24. 3809 20. 20. 23. 23. 3812 21. 22. 23. 24. 3815 20. 20. 20. 19. 3820 23. 22. 24. 25. 3821 23. 21. 22. 25. 3838 23. 22. 23. 25.MEAN 22. 21. 23. 24.S.D. 1.8 2.1 2.5 2.8S.E. 0.5 0.6 0.6 0.7 N 15 15 15 15

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A8 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY] MALE GROUP: 2500 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3763 21. 20. 21. 23. 3767 27. 23. 26. 29. 3771 24. 23. 24. 26. 3775 22. 17. 20. 22. 3783 23. 24. 24. 25. 3785 21. 21. 25. 23. 3795 22. 17. 20. 20. 3804 23. 18. 20. 21. 3807 23. 21. 22. 22. 3810 19. 20. 21. 21. 3814 26. 19. 23. 24. 3817 23. 20. 23. 24. 3822 23. 17. 22. 23. 3831 20. 20. 23. 18. 3839 24. 22. 23. 25.MEAN 23. 20. 22. 23.S.D. 2.1 2.3 1.8 2.7S.E. 0.5 0.6 0.5 0.7 N 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A8 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY] FEMALE GROUP: 0 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3677 18. 19. 19. 20. 3686 15. 17. 19. 19. 3691 24. 22. 23. 24. 3693 17. 18. 19. 20. 3694 15. 15. 18. 18. 3696 17. 18. 19. 19. 3704 16. 17. 17. 17. 3714 16. 17. 18. 17. 3719 15. 16. 16. 17. 3723 16. 17. 17. 17. 3725 14. 15. 16. 18. 3733 19. 23. 22. 23. 3738 17. 17. 19. 19. 3744 17. 17. 18. 18. 3757 18. 20. 21. 21.MEAN 17. 18. 19. 19.S.D. 2.4 2.3 2.0 2.2S.E. 0.6 0.6 0.5 0.6 N 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A8 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY] FEMALE GROUP: 1000 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3672 14. 18. 17. 17. 3675 17. 16. 19. 17. 3683 16. 17. 18. 17. 3690 16. 18. 17. 18. 3695 16. 17. 18. 19. 3697 17. 19. 21. 22. 3700 16. 16. 17. 17. 3702 18. 18. 21. 21. 3706 17. 19. 20. 20. 3712 16. 17. 19. 20. 3713 17. 18. 18. 18. 3718 15. 17. 18. 18. 3720 14. 15. 18. 18. 3743 18. 18. 18. 18. 3747 20. 20. 24. 26.MEAN 16. 18. 19. 19.S.D. 1.6 1.3 1.9 2.5S.E. 0.4 0.3 0.5 0.6 N 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A8 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY] FEMALE GROUP: 1500 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3674 16. 17. 17. 20. 3684 19. 17. 19. 20. 3701 16. 14. 16. 18. 3708 16. 16. 18. 18. 3711 17. 18. 20. 21. 3722 17. 17. 17. 18. 3724 17. 18. 20. 18. 3726 17. 16. 17. 18. 3727 17. 17. 18. 19. 3728 17. 18. 20. 20. 3729 16. 17. 18. 19. 3731 15. 15. 17. 19. 3734 16. 15. 18. 18. 3748 18. 18. 18. 19. 3756 14. 15. 16. 17.MEAN 17. 17. 18. 19.S.D. 1.2 1.3 1.3 1.1S.E. 0.3 0.3 0.3 0.3 N 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A8 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY] FEMALE GROUP: 2000 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3676 19. 18. 20. 20. 3678 17. 16. 19. 20. 3682 17. 19. 20. 18. 3705 15. 16. 13. 18. 3709 19. 16. 17. 19. 3710 16. 17. 18. 18. 3716 18. 18. 20. 21. 3732 14. 13. 15. 17. 3739 22. 15. 17. 18. 3740 14. 19. 20. 19. 3745 17. 16. 18. 18. 3746 14. 14. 16. 18. 3749 16. 18. 24. 19. 3751 17. 18. 19. 20. 3754 18. 16. 20. 20.MEAN 17. 17. 18. 19.S.D. 2.2 1.8 2.6 1.1S.E. 0.6 0.5 0.7 0.3 N 15 15 15 15

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A8 (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FOOD CONSUMPTION [G/ANIMAL/DAY] FEMALE GROUP: 2500 PPM WEEK -1 TO 0 0 TO 1 1 TO 2 2 TO 3----------------------------------------------------------------------------------------------------------------------------------- ANIMAL 3673 17. 17. 19. 19. 3679 16. 16. 17. 18. 3680 19. 17. 20. 20. 3685 15. 14. 15. 15. 3688 17. 19. 21. 20. 3689 18. 16. 20. 18. 3698 19. 17. 18. 20. 3703 16. 16. 16. 16. 3717 15. 17. 17. 16. 3721 15. 16. 18. 18. 3730 16. 16. 19. 18. 3742 17. 17. 18. 18. 3753 17. 14. 17. 18. 3755 16. 18. 22. 19. 3758 17. 19. 19. 21.MEAN 17. 17. 18. 18.S.D. 1.3 1.5 1.9 1.7S.E. 0.3 0.4 0.5 0.4 N 15 15 15 15 PBFTSv4.45 06/15/2009

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
	
	


	
 


	   	 








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534015

APPENDIX  
	

	

 
 

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- WHITE RED HEMO- HEMATO- RETIC- RETIC ANIMAL CELL CELL GLOBIN CRIT MCV MCH MCHC PLATELET ULOCYTE ABSOLUTE----------------------------------------------------------------------------------------------------------------------------------- thous/uL mil/uL g/dL % fL pg g/dL thous/uL % thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM MALES 3789 8.43 8.50 16.0 44.3 52.1 18.9 36.2 1194. 1.5 128.8 3790 10.94 8.60 16.0 44.8 52.0 18.6 35.8 1401. 2.0 171.9 3791 10.01 7.93 14.7 40.6 51.2 18.5 36.2 1154. 2.5 201.9 3802 13.67 8.83 16.7 47.7 54.0 18.9 35.0 1043. 1.8 159.2 3811 7.80 8.40 16.1 45.1 53.7 19.1 35.7 1326. 2.1 175.7 MEAN 10.17 8.45 15.9 44.5 52.6 18.8 35.8 1224. 2.0 167.5 S.D. 2.319 0.333 0.73 2.55 1.20 0.24 0.49 141.7 0.37 26.63 S.E. 1.037 0.149 0.33 1.14 0.54 0.11 0.22 63.4 0.17 11.91 N 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEUTRO- LYMPH- EOSIN- LG UNST- ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL AIN CELL----------------------------------------------------------------------------------------------------------------------------------- % % % % % %-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM MALES 3789 13.5 82.3 2.1 0.9 0.4 0.7 3790 9.1 87.1 1.8 0.5 0.3 1.2 3791 16.4 77.8 3.3 1.5 0.2 0.8 3802 13.7 81.8 2.0 0.7 0.4 1.4 3811 15.1 80.7 2.0 1.0 0.4 0.9 MEAN 13.6 81.9 2.2 0.9 0.3 1.0 S.D. 2.75 3.37 0.60 0.38 0.09 0.29 S.E. 1.23 1.51 0.27 0.17 0.04 0.13 N 5 5 5 5 5 5

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEU LYMPH MONO EOS BASO LUC PLATELET RBC ANIMAL ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ESTIMATE MORPHOLOGY----------------------------------------------------------------------------------------------------------------------------------- thous/uL thous/uL thous/uL thous/uL thous/uL thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM MALES 3789 1.14 6.94 0.18 0.08 0.04 0.06 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3790 0.99 9.53 0.20 0.05 0.03 0.13 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3791 1.64 7.79 0.33 0.15 0.02 0.08 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3802 1.87 11.19 0.27 0.10 0.06 0.19 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3811 1.17 6.29 0.16 0.08 0.03 0.07 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED MEAN 1.36 8.35 0.23 0.09 0.04 0.11 S.D. 0.374 2.000 0.070 0.037 0.015 0.054 S.E. 0.167 0.895 0.032 0.017 0.007 0.024 N 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED CELL HGB ANIMAL PROTIME APTT WIDTH WIDTH----------------------------------------------------------------------------------------------------------------------------------- seconds seconds % g/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM MALES 3789 16.9 17.8 12.1 2.43 3790 17.9 19.7 12.0 2.72 3791 CLT CLT 12.0 2.70 3802 17.3 20.2 12.5 2.38 3811 16.0 19.4 12.3 2.52 MEAN 17.0 19.3 12.2 2.55 S.D. 0.80 1.04 0.22 0.155 S.E. 0.40 0.52 0.10 0.069 N 4 4 5 5-----------------------------------------------------------------------------------------------------------------------------------CLT = CLOTTED----------------------------------------------------------------------------------------------------------------------------------- g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- WHITE RED HEMO- HEMATO- RETIC- RETIC ANIMAL CELL CELL GLOBIN CRIT MCV MCH MCHC PLATELET ULOCYTE ABSOLUTE----------------------------------------------------------------------------------------------------------------------------------- thous/uL mil/uL g/dL % fL pg g/dL thous/uL % thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM MALES 3764 14.36 8.16 14.5 41.2 50.4 17.7 35.2 904. 1.9 157.3 3801 16.56 8.09 14.8 43.4 53.7 18.3 34.1 1360. 2.9 231.3 3806 10.81 8.11 16.0 45.9 56.6 19.7 34.9 1403. 2.1 173.0 3824 7.30 8.41 16.3 44.4 52.9 19.4 36.7 1124. 2.0 164.3 3840 11.09 9.39 16.6 46.5 49.5 17.6 35.6 1376. 1.9 174.1 MEAN 12.02 8.43 15.6 44.3 52.6 18.5 35.3 1233. 2.2 180.0 S.D. 3.560 0.551 0.93 2.11 2.82 0.97 0.96 215.4 0.42 29.48 S.E. 1.592 0.246 0.42 0.94 1.26 0.43 0.43 96.3 0.19 13.19 N 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEUTRO- LYMPH- EOSIN- LG UNST- ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL AIN CELL----------------------------------------------------------------------------------------------------------------------------------- % % % % % %-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM MALES 3764 14.7 80.5 2.4 0.9 0.4 1.0 3801 8.9 87.3 1.6 0.6 0.4 1.2 3806 8.7 87.4 2.1 0.5 0.3 0.9 3824 15.5 80.4 1.9 1.2 0.3 0.7 3840 11.6 84.9 1.3 1.1 0.4 0.7 MEAN 11.9 84.1 1.9 0.9 0.4 0.9 S.D. 3.17 3.48 0.43 0.30 0.05 0.21 S.E. 1.42 1.56 0.19 0.14 0.02 0.09 N 5 5 5 5 5 5

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEU LYMPH MONO EOS BASO LUC PLATELET RBC ANIMAL ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ESTIMATE MORPHOLOGY----------------------------------------------------------------------------------------------------------------------------------- thous/uL thous/uL thous/uL thous/uL thous/uL thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM MALES 3764 2.12 11.56 0.35 0.14 0.05 0.15 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3801 1.47 14.46 0.27 0.10 0.07 0.19 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3806 0.94 9.45 0.23 0.05 0.04 0.10 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3824 1.13 5.87 0.14 0.09 0.02 0.05 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3840 1.29 9.42 0.14 0.13 0.04 0.07 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED MEAN 1.39 10.15 0.23 0.10 0.04 0.11 S.D. 0.453 3.159 0.090 0.036 0.018 0.058 S.E. 0.202 1.413 0.040 0.016 0.008 0.026 N 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED CELL HGB ANIMAL PROTIME APTT WIDTH WIDTH----------------------------------------------------------------------------------------------------------------------------------- seconds seconds % g/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM MALES 3764 17.0 19.3 12.9 2.76 3801 17.9 23.3 13.0 2.57 3806 16.8 20.3 11.9 2.16 3824 16.8 22.3 12.2 2.33 3840 16.6 20.6 12.1 2.35 MEAN 17.0 21.2 12.4 2.43 S.D. 0.51 1.61 0.50 0.233 S.E. 0.23 0.72 0.22 0.104 N 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- g/dL = GRAMS/DECILITER

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- WHITE RED HEMO- HEMATO- RETIC- RETIC ANIMAL CELL CELL GLOBIN CRIT MCV MCH MCHC PLATELET ULOCYTE ABSOLUTE----------------------------------------------------------------------------------------------------------------------------------- thous/uL mil/uL g/dL % fL pg g/dL thous/uL % thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM MALES 3765 13.98 8.14 15.6 44.4 54.6 19.1 35.0 1387. 2.4 193.9 3766 16.95 8.59 16.2 46.0 53.5 18.8 35.2 1503. 2.1 183.5 3777 12.51 8.29 15.5 43.4 52.3 18.7 35.8 1235. 1.7 141.1 3778 7.61 8.07 15.0 42.6 52.8 18.6 35.2 148. 3.7 298.9 3798 8.58 8.78 16.5 45.6 51.9 18.8 36.2 1573. 2.0 175.2 MEAN 11.93 8.37 15.8 44.4 53.0 18.8 35.5 1169. 2.4 198.5 S.D. 3.861 0.302 0.59 1.44 1.07 0.19 0.50 585.0 0.78 59.51 S.E. 1.727 0.135 0.27 0.64 0.48 0.08 0.22 261.6 0.35 26.61 N 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEUTRO- LYMPH- EOSIN- LG UNST- ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL AIN CELL----------------------------------------------------------------------------------------------------------------------------------- % % % % % %-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM MALES 3765 5.0 91.3 1.6 0.8 0.6 0.5 3766 9.1 86.7 2.1 0.6 0.4 1.0 3777 10.1 86.1 1.6 0.6 0.5 1.0 3778 17.5 78.2 2.2 0.8 0.4 0.9 3798 10.6 85.6 1.3 1.2 0.3 1.0 MEAN 10.5 85.6 1.8 0.8 0.4 0.9 S.D. 4.51 4.71 0.38 0.24 0.11 0.22 S.E. 2.02 2.11 0.17 0.11 0.05 0.10 N 5 5 5 5 5 5

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEU LYMPH MONO EOS BASO LUC PLATELET RBC ANIMAL ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ESTIMATE MORPHOLOGY----------------------------------------------------------------------------------------------------------------------------------- thous/uL thous/uL thous/uL thous/uL thous/uL thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM MALES 3765 0.70 12.77 0.23 0.12 0.09 0.07 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3766 1.54 14.70 0.36 0.11 0.07 0.17 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3777 1.27 10.77 0.20 0.08 0.07 0.12 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3778 1.33 5.95 0.17 0.06 0.03 0.07 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3798 0.91 7.34 0.11 0.10 0.03 0.08 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED MEAN 1.15 10.31 0.21 0.09 0.06 0.10 S.D. 0.339 3.653 0.093 0.024 0.027 0.043 S.E. 0.151 1.633 0.042 0.011 0.012 0.019 N 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED CELL HGB ANIMAL PROTIME APTT WIDTH WIDTH----------------------------------------------------------------------------------------------------------------------------------- seconds seconds % g/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM MALES 3765 17.2 22.2 12.6 2.49 3766 17.9 20.6 12.4 2.54 3777 16.5 20.6 11.5 2.44 3778 17.2 20.0 12.5 2.53 3798 16.0 18.2 12.3 2.72 MEAN 17.0 20.3 12.3 2.54 S.D. 0.73 1.44 0.44 0.106 S.E. 0.33 0.64 0.20 0.047 N 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- WHITE RED HEMO- HEMATO- RETIC- RETIC ANIMAL CELL CELL GLOBIN CRIT MCV MCH MCHC PLATELET ULOCYTE ABSOLUTE----------------------------------------------------------------------------------------------------------------------------------- thous/uL mil/uL g/dL % fL pg g/dL thous/uL % thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM MALES 3792 14.85 7.88 15.3 43.0 54.6 19.4 35.5 1118. 2.7 215.9 3799 11.60 8.53 15.8 44.0 51.6 18.5 35.8 1329. 2.1 177.3 3809 9.22 6.60 12.7 34.8 52.7 19.2 36.4 978. 3.4 225.2 3812 10.20 8.35 16.1 46.5 55.8 19.3 34.6 1202. 2.2 180.6 3815 9.10 8.76 15.4 43.2 49.3 17.6 35.8 1340. 2.4 210.3 MEAN 10.99 8.02 15.1 42.3 52.8 18.8 35.6 1193. 2.6 201.9 S.D. 2.377 0.859 1.36 4.42 2.55 0.76 0.66 151.7 0.52 21.61 S.E. 1.063 0.384 0.61 1.98 1.14 0.34 0.29 67.8 0.23 9.67 N 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEUTRO- LYMPH- EOSIN- LG UNST- ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL AIN CELL----------------------------------------------------------------------------------------------------------------------------------- % % % % % %-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM MALES 3792 10.9 84.7 2.2 1.1 0.3 0.9 3799 13.9 82.9 1.2 0.6 0.3 1.1 3809 20.8 75.4 2.1 0.7 0.2 0.8 3812 13.7 83.4 1.5 0.6 0.3 0.6 3815 20.5 76.4 1.5 0.6 0.2 0.8 MEAN 16.0 80.6 1.7 0.7 0.3 0.8 S.D. 4.44 4.32 0.43 0.22 0.05 0.18 S.E. 1.99 1.93 0.19 0.10 0.02 0.08 N 5 5 5 5 5 5

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEU LYMPH MONO EOS BASO LUC PLATELET RBC ANIMAL ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ESTIMATE MORPHOLOGY----------------------------------------------------------------------------------------------------------------------------------- thous/uL thous/uL thous/uL thous/uL thous/uL thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM MALES 3792 1.62 12.57 0.33 0.16 0.04 0.13 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3799 1.61 9.61 0.14 0.07 0.04 0.13 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3809 1.92 6.95 0.19 0.06 0.02 0.08 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3812 1.40 8.51 0.15 0.06 0.03 0.06 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3815 1.86 6.95 0.14 0.06 0.02 0.07 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED MEAN 1.68 8.92 0.19 0.08 0.03 0.09 S.D. 0.210 2.331 0.081 0.044 0.010 0.034 S.E. 0.094 1.042 0.036 0.020 0.004 0.015 N 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED CELL HGB ANIMAL PROTIME APTT WIDTH WIDTH----------------------------------------------------------------------------------------------------------------------------------- seconds seconds % g/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM MALES 3792 16.8 20.3 12.8 2.42 3799 17.2 18.1 12.6 2.55 3809 17.5 18.7 12.9 2.65 3812 17.1 16.9 11.9 2.33 3815 18.1 22.9 12.1 2.60 MEAN 17.3 19.4 12.5 2.51 S.D. 0.49 2.32 0.44 0.132 S.E. 0.22 1.04 0.20 0.059 N 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- WHITE RED HEMO- HEMATO- RETIC- RETIC ANIMAL CELL CELL GLOBIN CRIT MCV MCH MCHC PLATELET ULOCYTE ABSOLUTE----------------------------------------------------------------------------------------------------------------------------------- thous/uL mil/uL g/dL % fL pg g/dL thous/uL % thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM MALES 3783 6.64 8.06 14.9 40.8 50.7 18.5 36.4 1410. 1.7 133.1 3785 8.28 8.67 16.1 45.5 52.5 18.5 35.3 1517. 2.2 187.5 3807 11.23 8.77 15.7 43.9 50.1 17.9 35.8 1445. 2.0 177.8 3810 8.02 8.49 15.7 45.1 53.1 18.5 34.9 1317. 1.9 163.4 3831 9.90 8.01 15.0 42.7 53.3 18.7 35.1 1515. 1.9 155.9 MEAN 8.81 8.40 15.5 43.6 51.9 18.4 35.5 1441. 1.9 163.5 S.D. 1.779 0.348 0.51 1.91 1.45 0.30 0.60 83.1 0.18 20.99 S.E. 0.796 0.156 0.23 0.85 0.65 0.14 0.27 37.2 0.08 9.39 N 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEUTRO- LYMPH- EOSIN- LG UNST- ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL AIN CELL----------------------------------------------------------------------------------------------------------------------------------- % % % % % %-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM MALES 3783 26.5 65.9 4.9 1.3 0.3 1.0 3785 13.7 82.0 2.0 1.1 0.3 0.8 3807 9.5 87.5 1.5 0.4 0.5 0.6 3810 11.8 85.0 1.4 0.8 0.4 0.6 3831 15.9 80.1 2.0 0.6 0.5 0.9 MEAN 15.5 80.1 2.4 0.8 0.4 0.8 S.D. 6.60 8.43 1.45 0.36 0.10 0.18 S.E. 2.95 3.77 0.65 0.16 0.04 0.08 N 5 5 5 5 5 5

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEU LYMPH MONO EOS BASO LUC PLATELET RBC ANIMAL ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ESTIMATE MORPHOLOGY----------------------------------------------------------------------------------------------------------------------------------- thous/uL thous/uL thous/uL thous/uL thous/uL thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM MALES 3783 1.76 4.37 0.32 0.09 0.02 0.06 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3785 1.14 6.79 0.17 0.09 0.02 0.07 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3807 1.07 9.83 0.17 0.05 0.05 0.07 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3810 0.95 6.81 0.11 0.06 0.03 0.05 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3831 1.58 7.93 0.20 0.06 0.05 0.09 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED MEAN 1.30 7.15 0.19 0.07 0.03 0.07 S.D. 0.350 1.985 0.078 0.019 0.015 0.015 S.E. 0.157 0.888 0.035 0.008 0.007 0.007 N 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED CELL HGB ANIMAL PROTIME APTT WIDTH WIDTH----------------------------------------------------------------------------------------------------------------------------------- seconds seconds % g/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM MALES 3783 17.6 21.5 12.0 2.53 3785 16.2 22.5 12.4 2.50 3807 17.5 23.3 12.5 2.45 3810 17.4 20.6 13.4 2.46 3831 19.3 14.6 12.7 2.58 MEAN 17.6 20.5 12.6 2.50 S.D. 1.11 3.45 0.51 0.053 S.E. 0.49 1.54 0.23 0.024 N 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 21 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- WHITE RED HEMO- HEMATO- RETIC- RETIC ANIMAL CELL CELL GLOBIN CRIT MCV MCH MCHC PLATELET ULOCYTE ABSOLUTE----------------------------------------------------------------------------------------------------------------------------------- thous/uL mil/uL g/dL % fL pg g/dL thous/uL % thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM FEMALES 3691 12.64 7.49 15.2 42.3 56.5 20.2 35.9 1651. 2.5 185.7 3693 8.40 7.75 15.3 39.9 51.5 19.8 38.4 1821. 1.9 143.4 3719 5.44 7.87 14.2 38.2 48.6 18.1 37.3 1386. 1.9 150.3 3723 8.16 8.44 14.9 42.2 49.9 17.7 35.4 1221. 1.9 161.4 3733 9.98 8.00 15.3 42.9 53.6 19.2 35.8 1325. 2.5 203.9 MEAN 8.92 7.91 15.0 41.1 52.0 19.0 36.6 1481. 2.1 168.9 S.D. 2.642 0.351 0.47 1.98 3.12 1.07 1.25 247.7 0.33 25.30 S.E. 1.182 0.157 0.21 0.89 1.40 0.48 0.56 110.8 0.15 11.31 N 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 22 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEUTRO- LYMPH- EOSIN- LG UNST- ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL AIN CELL----------------------------------------------------------------------------------------------------------------------------------- % % % % % %-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM FEMALES 3691 4.5 92.8 0.8 0.6 0.4 0.9 3693 32.0 64.0 1.7 1.1 0.3 1.0 3719 12.0 83.3 2.0 1.3 0.2 1.1 3723 10.1 86.7 1.5 0.6 0.2 0.8 3733 11.9 83.9 2.0 0.8 0.4 1.0 MEAN 14.1 82.1 1.6 0.9 0.3 1.0 S.D. 10.46 10.82 0.49 0.31 0.10 0.11 S.E. 4.68 4.84 0.22 0.14 0.04 0.05 N 5 5 5 5 5 5

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 23 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEU LYMPH MONO EOS BASO LUC PLATELET RBC ANIMAL ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ESTIMATE MORPHOLOGY----------------------------------------------------------------------------------------------------------------------------------- thous/uL thous/uL thous/uL thous/uL thous/uL thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM FEMALES 3691 0.58 11.73 0.10 0.08 0.05 0.12 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3693 2.69 5.37 0.14 0.09 0.02 0.08 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3719 0.65 4.53 0.11 0.07 0.01 0.06 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3723 0.83 7.08 0.13 0.05 0.02 0.07 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3733 1.19 8.37 0.20 0.08 0.04 0.10 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED MEAN 1.19 7.42 0.14 0.07 0.03 0.09 S.D. 0.872 2.835 0.039 0.015 0.016 0.024 S.E. 0.390 1.268 0.017 0.007 0.007 0.011 N 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 24 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED CELL HGB ANIMAL PROTIME APTT WIDTH WIDTH----------------------------------------------------------------------------------------------------------------------------------- seconds seconds % g/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM FEMALES 3691 18.1 14.2 10.8 2.22 3693 18.5 15.3 11.6 2.51 3719 17.3 15.1 11.1 2.61 3723 18.8 19.2 11.0 2.37 3733 17.8 14.0 11.4 2.45 MEAN 18.1 15.6 11.2 2.43 S.D. 0.59 2.11 0.32 0.147 S.E. 0.26 0.94 0.14 0.066 N 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 25 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- WHITE RED HEMO- HEMATO- RETIC- RETIC ANIMAL CELL CELL GLOBIN CRIT MCV MCH MCHC PLATELET ULOCYTE ABSOLUTE----------------------------------------------------------------------------------------------------------------------------------- thous/uL mil/uL g/dL % fL pg g/dL thous/uL % thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM FEMALES 3672 8.23 7.79 14.8 41.2 52.9 19.1 36.1 1221. 2.4 185.1 3683 11.14 8.29 15.2 40.9 49.3 18.3 37.1 1252. 2.0 166.0 3690 4.16 8.78 16.0 45.5 51.9 18.2 35.2 1534. 1.4 122.2 3697 6.88 8.08 15.4 42.7 52.8 19.1 36.2 1438. 1.8 145.0 3706 7.37 7.68 14.7 39.9 52.0 19.1 36.8 1498. 1.3 96.8 MEAN 7.56 8.12 15.2 42.0 51.8 18.8 36.3 1389. 1.8 143.0 S.D. 2.516 0.438 0.52 2.18 1.46 0.47 0.73 143.4 0.45 34.90 S.E. 1.125 0.196 0.23 0.97 0.65 0.21 0.33 64.1 0.20 15.61 N 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 26 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEUTRO- LYMPH- EOSIN- LG UNST- ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL AIN CELL----------------------------------------------------------------------------------------------------------------------------------- % % % % % %-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM FEMALES 3672 6.7 89.6 1.5 1.1 0.2 0.9 3683 14.6 80.1 3.0 1.2 0.4 0.8 3690 17.2 78.6 1.4 1.7 0.3 0.7 3697 12.2 83.4 2.0 1.5 0.3 0.5 3706 11.2 85.8 1.1 0.7 0.3 0.9 MEAN 12.4 83.5 1.8 1.2 0.3 0.8 S.D. 3.93 4.42 0.74 0.38 0.07 0.17 S.E. 1.76 1.98 0.33 0.17 0.03 0.07 N 5 5 5 5 5 5

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 27 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEU LYMPH MONO EOS BASO LUC PLATELET RBC ANIMAL ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ESTIMATE MORPHOLOGY----------------------------------------------------------------------------------------------------------------------------------- thous/uL thous/uL thous/uL thous/uL thous/uL thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM FEMALES 3672 0.55 7.38 0.12 0.09 0.02 0.07 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3683 1.63 8.92 0.33 0.13 0.04 0.09 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3690 0.72 3.27 0.06 0.07 0.01 0.03 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3697 0.84 5.74 0.14 0.10 0.02 0.04 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3706 0.83 6.33 0.08 0.05 0.02 0.06 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED MEAN 0.91 6.33 0.15 0.09 0.02 0.06 S.D. 0.417 2.093 0.108 0.030 0.011 0.024 S.E. 0.186 0.936 0.048 0.014 0.005 0.011 N 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 28 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED CELL HGB ANIMAL PROTIME APTT WIDTH WIDTH----------------------------------------------------------------------------------------------------------------------------------- seconds seconds % g/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM FEMALES 3672 18.2 16.5 11.0 2.39 3683 19.5 17.4 11.0 2.42 3690 16.6 15.3 11.1 2.43 3697 17.0 15.4 11.6 2.37 3706 17.6 15.9 11.1 2.33 MEAN 17.8 16.1 11.2 2.39 S.D. 1.14 0.87 0.25 0.040 S.E. 0.51 0.39 0.11 0.018 N 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 29 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- WHITE RED HEMO- HEMATO- RETIC- RETIC ANIMAL CELL CELL GLOBIN CRIT MCV MCH MCHC PLATELET ULOCYTE ABSOLUTE----------------------------------------------------------------------------------------------------------------------------------- thous/uL mil/uL g/dL % fL pg g/dL thous/uL % thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM FEMALES 3684 9.09 7.99 14.6 40.6 50.8 18.3 35.9 1362. 1.7 132.0 3724 10.83 7.96 15.6 43.0 54.0 19.6 36.2 1546. 2.0 158.2 3728 8.76 8.15 15.1 42.2 51.8 18.5 35.8 1635. 2.0 163.7 3729 10.95 6.40 12.1 33.7 52.6 18.9 35.8 1553. 4.6 296.8 3748 4.83 8.35 15.8 43.5 52.1 18.9 36.3 1474. 1.6 134.9 MEAN 8.89 7.77 14.6 40.6 52.3 18.8 36.0 1514. 2.4 177.1 S.D. 2.477 0.781 1.49 4.01 1.17 0.50 0.23 102.3 1.25 68.34 S.E. 1.108 0.349 0.67 1.79 0.52 0.22 0.10 45.8 0.56 30.56 N 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 30 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEUTRO- LYMPH- EOSIN- LG UNST- ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL AIN CELL----------------------------------------------------------------------------------------------------------------------------------- % % % % % %-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM FEMALES 3684 9.8 85.7 1.6 1.5 0.3 1.0 3724 11.4 85.3 1.2 1.1 0.3 0.9 3728 10.5 85.2 2.1 1.0 0.3 0.9 3729 15.0 81.1 2.0 1.2 0.2 0.5 3748 11.4 83.6 2.7 1.1 0.3 0.8 MEAN 11.6 84.2 1.9 1.2 0.3 0.8 S.D. 2.01 1.90 0.56 0.19 0.04 0.19 S.E. 0.90 0.85 0.25 0.09 0.02 0.09 N 5 5 5 5 5 5

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 31 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEU LYMPH MONO EOS BASO LUC PLATELET RBC ANIMAL ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ESTIMATE MORPHOLOGY----------------------------------------------------------------------------------------------------------------------------------- thous/uL thous/uL thous/uL thous/uL thous/uL thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM FEMALES 3684 0.89 7.79 0.15 0.14 0.02 0.09 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3724 1.23 9.24 0.13 0.12 0.03 0.09 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3728 0.92 7.46 0.18 0.09 0.02 0.08 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3729 1.64 8.88 0.22 0.13 0.03 0.05 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3748 0.55 4.04 0.13 0.05 0.02 0.04 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED MEAN 1.05 7.48 0.16 0.11 0.02 0.07 S.D. 0.410 2.061 0.038 0.036 0.005 0.023 S.E. 0.183 0.922 0.017 0.016 0.002 0.010 N 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 32 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED CELL HGB ANIMAL PROTIME APTT WIDTH WIDTH----------------------------------------------------------------------------------------------------------------------------------- seconds seconds % g/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM FEMALES 3684 18.7 19.0 10.9 2.41 3724 18.7 18.0 11.2 2.33 3728 17.1 15.8 11.3 2.42 3729 18.4 15.5 13.5 2.76 3748 16.6 12.2 11.0 2.23 MEAN 17.9 16.1 11.6 2.43 S.D. 0.98 2.63 1.08 0.200 S.E. 0.44 1.18 0.49 0.089 N 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 33 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- WHITE RED HEMO- HEMATO- RETIC- RETIC ANIMAL CELL CELL GLOBIN CRIT MCV MCH MCHC PLATELET ULOCYTE ABSOLUTE----------------------------------------------------------------------------------------------------------------------------------- thous/uL mil/uL g/dL % fL pg g/dL thous/uL % thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM FEMALES 3682 6.02 7.12 13.6 36.5 51.2 19.1 37.3 889. 1.9 133.2 3705 9.00 8.31 15.3 42.9 51.6 18.4 35.7 1413. 1.8 147.0 3710 4.94 7.60 14.7 40.8 53.7 19.3 35.9 1233. 2.0 149.0 3740 8.18 8.67 16.4 45.9 52.9 18.8 35.6 1483. 1.8 155.8 3749 11.22 7.25 13.3 37.4 51.6 18.4 35.6 897. 2.3 163.4 MEAN 7.87 7.79 14.7 40.7 52.2 18.8 36.0 1183. 2.0 149.7 S.D. 2.480 0.675 1.27 3.89 1.06 0.41 0.73 280.0 0.21 11.24 S.E. 1.109 0.302 0.57 1.74 0.47 0.18 0.32 125.2 0.09 5.02 N 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 34 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEUTRO- LYMPH- EOSIN- LG UNST- ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL AIN CELL----------------------------------------------------------------------------------------------------------------------------------- % % % % % %-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM FEMALES 3682 25.3 68.5 3.4 2.0 0.1 0.7 3705 10.9 85.8 0.8 1.0 0.5 1.0 3710 14.5 81.8 2.0 1.1 0.2 0.4 3740 8.2 88.2 1.6 0.9 0.4 0.7 3749 7.4 89.4 1.1 0.6 0.4 1.1 MEAN 13.3 82.7 1.8 1.1 0.3 0.8 S.D. 7.28 8.47 1.02 0.53 0.16 0.28 S.E. 3.26 3.79 0.45 0.24 0.07 0.12 N 5 5 5 5 5 5

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 35 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEU LYMPH MONO EOS BASO LUC PLATELET RBC ANIMAL ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ESTIMATE MORPHOLOGY----------------------------------------------------------------------------------------------------------------------------------- thous/uL thous/uL thous/uL thous/uL thous/uL thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM FEMALES 3682 1.52 4.12 0.20 0.12 0.01 0.04 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3705 0.98 7.72 0.07 0.09 0.04 0.09 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3710 0.72 4.04 0.10 0.06 0.01 0.02 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3740 0.67 7.21 0.13 0.07 0.03 0.06 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3749 0.83 10.03 0.13 0.07 0.04 0.12 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED MEAN 0.94 6.62 0.13 0.08 0.03 0.07 S.D. 0.343 2.554 0.048 0.024 0.015 0.040 S.E. 0.154 1.142 0.022 0.011 0.007 0.018 N 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 36 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED CELL HGB ANIMAL PROTIME APTT WIDTH WIDTH----------------------------------------------------------------------------------------------------------------------------------- seconds seconds % g/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM FEMALES 3682 16.8 16.8 11.8 2.59 3705 17.4 16.5 11.1 2.15 3710 16.9 19.3 11.7 2.52 3740 18.1 14.3 11.4 2.48 3749 17.8 14.3 11.4 2.41 MEAN 17.4 16.2 11.5 2.43 S.D. 0.56 2.08 0.28 0.170 S.E. 0.25 0.93 0.12 0.076 N 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 37 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- WHITE RED HEMO- HEMATO- RETIC- RETIC ANIMAL CELL CELL GLOBIN CRIT MCV MCH MCHC PLATELET ULOCYTE ABSOLUTE----------------------------------------------------------------------------------------------------------------------------------- thous/uL mil/uL g/dL % fL pg g/dL thous/uL % thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM FEMALES 3688 8.55 7.74 14.3 39.5 51.1 18.5 36.2 1499. 1.8 137.7 3703 6.75 7.44 13.6 37.7 50.8 18.3 36.1 1143. 2.0 151.9 3717 7.10 9.00 16.3 44.3 49.3 18.1 36.8 1457. 1.4 121.8 3755 4.16 7.03 13.4 37.6 53.5 19.0 35.6 1043. 2.5 174.5 3758 12.36 7.87 15.0 41.6 52.9 19.0 36.0 1589. 2.4 186.6 MEAN 7.78 7.82 14.5 40.1 51.5 18.6 36.1 1346. 2.0 154.5 S.D. 3.008 0.736 1.18 2.84 1.69 0.41 0.43 238.6 0.45 26.40 S.E. 1.345 0.329 0.53 1.27 0.76 0.18 0.19 106.7 0.20 11.81 N 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER, mil/uL = MILLIONS/MICROLITER, fL = FEMTOLITERS, pg = PICOGRAMS, g/dL = GRAMS/DECILITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 38 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEUTRO- LYMPH- EOSIN- LG UNST- ANIMAL PHIL OCYTE MONOCYTE OPHIL BASOPHIL AIN CELL----------------------------------------------------------------------------------------------------------------------------------- % % % % % %-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM FEMALES 3688 19.0 75.6 2.9 1.4 0.2 0.9 3703 24.7 69.6 3.6 1.4 0.3 0.5 3717 10.6 84.4 2.2 1.5 0.4 0.9 3755 14.3 81.2 1.7 1.4 0.2 1.3 3758 16.6 80.0 1.5 0.7 0.3 0.9 MEAN 17.0 78.2 2.4 1.3 0.3 0.9 S.D. 5.28 5.73 0.87 0.33 0.08 0.28 S.E. 2.36 2.56 0.39 0.15 0.04 0.13 N 5 5 5 5 5 5

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 39 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- NEU LYMPH MONO EOS BASO LUC PLATELET RBC ANIMAL ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ABSOLUTE ESTIMATE MORPHOLOGY----------------------------------------------------------------------------------------------------------------------------------- thous/uL thous/uL thous/uL thous/uL thous/uL thous/uL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM FEMALES 3688 1.63 6.47 0.24 0.12 0.02 0.08 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3703 1.67 4.70 0.24 0.10 0.02 0.03 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3717 0.75 5.99 0.15 0.10 0.03 0.07 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3755 0.59 3.38 0.07 0.06 0.01 0.05 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED 3758 2.05 9.89 0.19 0.08 0.04 0.11 PLATELET ESTIMATE AND MORPHOLOGY NOT REVIEWED MEAN 1.34 6.09 0.18 0.09 0.02 0.07 S.D. 0.634 2.443 0.071 0.023 0.011 0.030 S.E. 0.284 1.092 0.032 0.010 0.005 0.014 N 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- thous/uL = THOUSANDS/MICROLITER

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 TABLE A9 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 40 INDIVIDUAL HEMATOLOGY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED CELL HGB ANIMAL PROTIME APTT WIDTH WIDTH----------------------------------------------------------------------------------------------------------------------------------- seconds seconds % g/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM FEMALES 3688 QNS QNS 11.2 2.36 3703 18.2 15.9 11.5 2.45 3717 CLT CLT 11.2 2.56 3755 17.8 14.2 11.9 2.45 3758 17.6 16.9 11.2 2.45 MEAN 17.9 15.7 11.4 2.45 S.D. 0.31 1.37 0.31 0.071 S.E. 0.18 0.79 0.14 0.032 N 3 3 5 5-----------------------------------------------------------------------------------------------------------------------------------CLT = CLOTTED, QNS = QUANTITY NOT SUFFICIENT----------------------------------------------------------------------------------------------------------------------------------- g/dL = GRAMS/DECILITER PHEMAv1.35 05/11/2009

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TOTAL A/G TOTAL UREA CREAT- ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL ALBUMIN PROTEIN GLOBULIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER----------------------------------------------------------------------------------------------------------------------------------- g/dL g/dL g/dL mg/dL mg/dL mg/dL U/L U/L U/L U/L-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM MALES 3789 4.3 6.1 1.8 2.34 0.11 17.1 0.2 211. 52. 191. 0.1 3790 4.6 6.3 1.7 2.68 0.10 14.3 0.3 254. 39. 89. 0.3 3791 4.3 6.5 2.2 1.98 0.12 16.1 0.3 189. 46. 99. 0.1 3802 4.5 6.9 2.4 1.91 0.10 12.6 0.2 182. 42. 101. 0.1 3811 4.4 6.6 2.2 2.04 0.10 12.3 0.2 149. 41. 92. 0.1 MEAN 4.4 6.5 2.1 2.19 0.11 14.5 0.2 197. 44. 114. 0.1 S.D. 0.13 0.30 0.30 0.319 0.009 2.11 0.05 38.9 5.1 43.1 0.09 S.E. 0.06 0.14 0.13 0.143 0.004 0.94 0.02 17.4 2.3 19.3 0.04 N 5 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CHOL- PHOS- POTAS- TRIGLY- ANIMAL GLUCOSE ESTEROL CALCIUM CHLORIDE PHORUS SIUM SODIUM CERIDE----------------------------------------------------------------------------------------------------------------------------------- mg/dL mg/dL mg/dL mEq/L mg/dL mEq/L mEq/L mg/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM MALES 3789 131. 42. 10.1 106. 7.8 5.33 144. 56. 3790 141. 44. 10.4 104. 7.7 4.93 144. 54. 3791 127. 53. 10.3 104. 8.2 5.44 143. 81. 3802 124. 42. 10.9 105. 8.6 4.75 146. 74. 3811 117. 81. 11.0 105. 8.0 5.35 147. 62. MEAN 128. 52. 10.5 105. 8.1 5.16 145. 65. S.D. 8.9 16.6 0.39 0.8 0.36 0.302 1.6 11.7 S.E. 4.0 7.4 0.17 0.4 0.16 0.135 0.7 5.2 N 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3---------------------------------------------------------------------------------------------------------------------------------- SORBITOL ANIMAL 'GENASE---------------------------------------------------------------------------------------------------------------------------------- U/L----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM MALES 3789 5. 3790 13. 3791 7. 3802 14. 3811 8. MEAN 9. S.D. 3.9 S.E. 1.7 N 5---------------------------------------------------------------------------------------------------------------------------------- U/L = INTERNATIONAL UNIT/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TOTAL A/G TOTAL UREA CREAT- ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL ALBUMIN PROTEIN GLOBULIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER----------------------------------------------------------------------------------------------------------------------------------- g/dL g/dL g/dL mg/dL mg/dL mg/dL U/L U/L U/L U/L-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM MALES 3764 4.1 6.0 1.9 2.15 0.09 12.0 0.2 141. 39. 100. 0.1 3801 4.1 6.1 2.0 2.06 0.11 16.2 0.3 216. 42. 82. 0.1 3806 4.4 6.5 2.1 2.08 0.09 12.3 0.3 180. 44. 80. 0.1 3824 4.6 6.6 2.0 2.27 0.12 12.5 0.3 145. 44. 89. 0.1 3840 4.4 6.7 2.3 1.88 0.13 10.3 0.2 137. 39. 85. 0.1 MEAN 4.3 6.4 2.1 2.09 0.11 12.7 0.3 164. 42. 87. 0.1 S.D. 0.22 0.31 0.15 0.142 0.018 2.16 0.05 33.8 2.5 7.9 0.00 S.E. 0.10 0.14 0.07 0.064 0.008 0.97 0.02 15.1 1.1 3.5 0.00 N 5 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CHOL- PHOS- POTAS- TRIGLY- ANIMAL GLUCOSE ESTEROL CALCIUM CHLORIDE PHORUS SIUM SODIUM CERIDE----------------------------------------------------------------------------------------------------------------------------------- mg/dL mg/dL mg/dL mEq/L mg/dL mEq/L mEq/L mg/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM MALES 3764 155. 39. 10.4 104. 7.1 4.91 142. 100. 3801 140. 61. 10.5 103. 8.7 5.51 145. 67. 3806 135. 65. 10.9 103. 9.0 4.82 146. 80. 3824 132. 53. 10.6 103. 8.2 4.86 146. 77. 3840 129. 71. 10.9 102. 8.6 5.02 144. 96. MEAN 138. 58. 10.7 103. 8.3 5.02 145. 84. S.D. 10.2 12.4 0.23 0.7 0.74 0.282 1.7 13.7 S.E. 4.6 5.5 0.10 0.3 0.33 0.126 0.7 6.1 N 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3---------------------------------------------------------------------------------------------------------------------------------- SORBITOL ANIMAL 'GENASE---------------------------------------------------------------------------------------------------------------------------------- U/L----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM MALES 3764 9. 3801 24. 3806 20. 3824 22. 3840 12. MEAN 17. S.D. 6.5 S.E. 2.9 N 5---------------------------------------------------------------------------------------------------------------------------------- U/L = INTERNATIONAL UNIT/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TOTAL A/G TOTAL UREA CREAT- ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL ALBUMIN PROTEIN GLOBULIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER----------------------------------------------------------------------------------------------------------------------------------- g/dL g/dL g/dL mg/dL mg/dL mg/dL U/L U/L U/L U/L-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM MALES 3765 4.1 6.0 1.9 2.13 0.13 13.5 0.2 247. 37. 74. 0.1 3766 4.4 6.7 2.3 1.93 0.11 18.9 0.3 260. 55. 87. 0.1 3777 4.4 6.5 2.1 2.11 0.10 16.8 0.3 238. 43. 94. 0.1 3778 4.3 6.2 1.9 2.24 0.11 12.4 0.2 176. 37. 71. 0.1 3798 4.4 6.5 2.1 2.04 0.11 12.6 0.1 150. 34. 79. 0.1 MEAN 4.3 6.4 2.1 2.09 0.11 14.8 0.2 214. 41. 81. 0.1 S.D. 0.13 0.28 0.17 0.115 0.011 2.88 0.08 48.3 8.4 9.5 0.00 S.E. 0.06 0.12 0.07 0.051 0.005 1.29 0.04 21.6 3.7 4.2 0.00 N 5 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CHOL- PHOS- POTAS- TRIGLY- ANIMAL GLUCOSE ESTEROL CALCIUM CHLORIDE PHORUS SIUM SODIUM CERIDE----------------------------------------------------------------------------------------------------------------------------------- mg/dL mg/dL mg/dL mEq/L mg/dL mEq/L mEq/L mg/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM MALES 3765 120. 48. 10.5 104. 7.9 4.29 144. 58. 3766 149. 58. 10.6 103. 8.8 5.80 143. 74. 3777 164. 46. 10.4 104. 8.0 5.32 143. 105. 3778 138. 59. 11.1 102. 7.8 3.97 145. 88. 3798 109. 57. 10.7 105. 8.4 4.89 146. 64. MEAN 136. 54. 10.7 104. 8.2 4.85 144. 78. S.D. 22.0 6.1 0.27 1.1 0.41 0.744 1.3 19.0 S.E. 9.9 2.7 0.12 0.5 0.19 0.333 0.6 8.5 N 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3---------------------------------------------------------------------------------------------------------------------------------- SORBITOL ANIMAL 'GENASE---------------------------------------------------------------------------------------------------------------------------------- U/L----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM MALES 3765 6. 3766 13. 3777 8. 3778 10. 3798 5. MEAN 8. S.D. 3.2 S.E. 1.4 N 5---------------------------------------------------------------------------------------------------------------------------------- U/L = INTERNATIONAL UNIT/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TOTAL A/G TOTAL UREA CREAT- ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL ALBUMIN PROTEIN GLOBULIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER----------------------------------------------------------------------------------------------------------------------------------- g/dL g/dL g/dL mg/dL mg/dL mg/dL U/L U/L U/L U/L-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM MALES 3792 4.0 6.1 2.0 1.97 0.15 10.9 0.2 166. 39. 82. 0.1 3799 4.6 6.5 1.9 2.45 0.10 13.1 0.2 238. 52. 96. 0.1 3809 4.1 6.2 2.1 1.97 0.10 15.1 0.2 190. 34. 67. 0.1 3812 4.4 6.5 2.1 2.05 0.06 11.6 0.3 194. 52. 98. 0.1 3815 4.5 6.6 2.1 2.18 0.09 11.9 0.2 150. 48. 82. 0.1 MEAN 4.3 6.4 2.0 2.12 0.10 12.5 0.2 188. 45. 85. 0.1 S.D. 0.26 0.22 0.09 0.201 0.032 1.65 0.04 33.4 8.1 12.6 0.00 S.E. 0.12 0.10 0.04 0.090 0.014 0.74 0.02 14.9 3.6 5.6 0.00 N 5 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CHOL- PHOS- POTAS- TRIGLY- ANIMAL GLUCOSE ESTEROL CALCIUM CHLORIDE PHORUS SIUM SODIUM CERIDE----------------------------------------------------------------------------------------------------------------------------------- mg/dL mg/dL mg/dL mEq/L mg/dL mEq/L mEq/L mg/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM MALES 3792 186. 86. 10.6 101. 7.7 4.74 141. 72. 3799 113. 56. 10.7 103. 7.9 4.82 143. 71. 3809 153. 70. 10.8 106. 8.0 5.14 144. 63. 3812 141. 40. 10.5 105. 8.1 5.02 145. 38. 3815 115. 42. 10.6 104. 8.0 4.72 144. 43. MEAN 142. 59. 10.6 104. 7.9 4.89 143. 57. S.D. 30.1 19.4 0.11 1.9 0.15 0.184 1.5 15.9 S.E. 13.5 8.7 0.05 0.9 0.07 0.082 0.7 7.1 N 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3---------------------------------------------------------------------------------------------------------------------------------- SORBITOL ANIMAL 'GENASE---------------------------------------------------------------------------------------------------------------------------------- U/L----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM MALES 3792 11. 3799 10. 3809 7. 3812 30. 3815 11. MEAN 14. S.D. 9.2 S.E. 4.1 N 5---------------------------------------------------------------------------------------------------------------------------------- U/L = INTERNATIONAL UNIT/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TOTAL A/G TOTAL UREA CREAT- ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL ALBUMIN PROTEIN GLOBULIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER----------------------------------------------------------------------------------------------------------------------------------- g/dL g/dL g/dL mg/dL mg/dL mg/dL U/L U/L U/L U/L-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM MALES 3783 4.4 6.6 2.2 1.98 0.12 14.2 0.4 161. 42. 88. 0.1 3785 4.3 6.5 2.2 2.01 0.13 9.7 0.2 158. 35. 80. 0.1 3807 4.6 6.9 2.3 2.04 0.14 11.6 0.3 206. 47. 93. 0.1 3810 4.4 6.5 2.1 2.11 0.10 13.1 0.2 186. 37. 67. 0.1 3831 4.0 6.3 2.3 1.73 0.10 9.4 0.3 149. 39. 76. 0.1 MEAN 4.3 6.6 2.2 1.97 0.12 11.6 0.3 172. 40. 81. 0.1 S.D. 0.22 0.22 0.08 0.145 0.018 2.09 0.08 23.4 4.7 10.2 0.00 S.E. 0.10 0.10 0.04 0.065 0.008 0.93 0.04 10.5 2.1 4.6 0.00 N 5 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CHOL- PHOS- POTAS- TRIGLY- ANIMAL GLUCOSE ESTEROL CALCIUM CHLORIDE PHORUS SIUM SODIUM CERIDE----------------------------------------------------------------------------------------------------------------------------------- mg/dL mg/dL mg/dL mEq/L mg/dL mEq/L mEq/L mg/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM MALES 3783 200. 74. 10.8 102. 8.0 4.68 143. 66. 3785 121. 67. 10.4 105. 7.4 5.59 145. 44. 3807 138. 59. 10.5 104. 7.2 4.92 143. 48. 3810 109. 61. 10.6 105. 6.8 4.70 146. 48. 3831 119. 75. 10.7 103. 8.4 4.59 144. 37. MEAN 137. 67. 10.6 104. 7.6 4.90 144. 49. S.D. 36.5 7.3 0.16 1.3 0.64 0.406 1.3 10.7 S.E. 16.3 3.3 0.07 0.6 0.29 0.182 0.6 4.8 N 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3---------------------------------------------------------------------------------------------------------------------------------- SORBITOL ANIMAL 'GENASE---------------------------------------------------------------------------------------------------------------------------------- U/L----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM MALES 3783 19. 3785 14. 3807 19. 3810 9. 3831 15. MEAN 15. S.D. 4.1 S.E. 1.9 N 5---------------------------------------------------------------------------------------------------------------------------------- U/L = INTERNATIONAL UNIT/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TOTAL A/G TOTAL UREA CREAT- ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL ALBUMIN PROTEIN GLOBULIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER----------------------------------------------------------------------------------------------------------------------------------- g/dL g/dL g/dL mg/dL mg/dL mg/dL U/L U/L U/L U/L-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM FEMALES 3691 4.6 7.0 2.3 1.98 0.15 14.0 0.3 103. 32. 80. 0.1 3693 4.8 6.9 2.1 2.27 0.12 15.3 0.2 99. 37. 67. 0.4 3719 4.3 6.3 1.9 2.26 0.08 14.1 0.2 96. 33. 82. 0.1 3723 4.6 6.9 2.3 1.96 0.13 13.9 0.3 131. 35. 86. 0.1 3733 4.9 7.1 2.2 2.23 0.17 14.8 0.3 97. 37. 92. 0.1 MEAN 4.6 6.8 2.2 2.14 0.13 14.4 0.3 105. 35. 81. 0.2 S.D. 0.23 0.31 0.17 0.156 0.034 0.61 0.05 14.7 2.3 9.3 0.13 S.E. 0.10 0.14 0.07 0.070 0.015 0.27 0.02 6.6 1.0 4.1 0.06 N 5 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CHOL- PHOS- POTAS- TRIGLY- ANIMAL GLUCOSE ESTEROL CALCIUM CHLORIDE PHORUS SIUM SODIUM CERIDE----------------------------------------------------------------------------------------------------------------------------------- mg/dL mg/dL mg/dL mEq/L mg/dL mEq/L mEq/L mg/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM FEMALES 3691 141. 86. 11.0 102. 6.7 4.08 143. 49. 3693 110. 44. 10.8 103. 7.5 4.18 143. 43. 3719 110. 58. 11.0 103. 7.9 4.66 144. 42. 3723 115. 60. 10.8 102. 7.7 4.36 142. 46. 3733 147. 49. 10.9 104. 6.4 4.44 144. 62. MEAN 125. 59. 10.9 103. 7.2 4.34 143. 48. S.D. 18.0 16.2 0.10 0.8 0.65 0.227 0.8 8.1 S.E. 8.0 7.3 0.04 0.4 0.29 0.101 0.4 3.6 N 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3---------------------------------------------------------------------------------------------------------------------------------- SORBITOL ANIMAL 'GENASE---------------------------------------------------------------------------------------------------------------------------------- U/L----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM FEMALES 3691 16. 3693 9. 3719 11. 3723 20. 3733 29. MEAN 17. S.D. 8.0 S.E. 3.6 N 5---------------------------------------------------------------------------------------------------------------------------------- U/L = INTERNATIONAL UNIT/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TOTAL A/G TOTAL UREA CREAT- ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL ALBUMIN PROTEIN GLOBULIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER----------------------------------------------------------------------------------------------------------------------------------- g/dL g/dL g/dL mg/dL mg/dL mg/dL U/L U/L U/L U/L-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM FEMALES 3672 4.6 6.9 2.2 2.07 0.10 14.0 0.3 103. 30. 89. 0.1 3683 4.5 6.7 2.3 1.94 0.08 16.9 0.2 144. 34. 82. 0.1 3690 5.3 7.3 2.0 2.68 0.17 10.6 0.3 117. 37. 86. 0.1 3697 5.2 7.3 2.0 2.56 0.13 13.8 0.2 93. 68. 134. 0.2 3706 4.7 7.1 2.4 2.01 0.22 14.9 0.3 85. 43. 78. 0.5 MEAN 4.9 7.1 2.2 2.25 0.14 14.0 0.3 108. 42. 94. 0.2 S.D. 0.36 0.26 0.18 0.342 0.056 2.28 0.05 23.2 15.1 22.9 0.17 S.E. 0.16 0.12 0.08 0.153 0.025 1.02 0.02 10.4 6.7 10.2 0.08 N 5 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CHOL- PHOS- POTAS- TRIGLY- ANIMAL GLUCOSE ESTEROL CALCIUM CHLORIDE PHORUS SIUM SODIUM CERIDE----------------------------------------------------------------------------------------------------------------------------------- mg/dL mg/dL mg/dL mEq/L mg/dL mEq/L mEq/L mg/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM FEMALES 3672 141. 61. 10.6 102. 7.2 4.39 142. 47. 3683 120. 60. 10.9 103. 6.9 4.41 142. 51. 3690 115. 77. 10.7 103. 6.9 4.45 145. 52. 3697 129. 70. 11.4 104. 7.3 4.67 145. 68. 3706 118. 62. 11.3 102. 8.5 4.23 146. 55. MEAN 125. 66. 11.0 103. 7.4 4.43 144. 55. S.D. 10.5 7.3 0.36 0.8 0.66 0.158 1.9 8.0 S.E. 4.7 3.3 0.16 0.4 0.30 0.071 0.8 3.6 N 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 21 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3---------------------------------------------------------------------------------------------------------------------------------- SORBITOL ANIMAL 'GENASE---------------------------------------------------------------------------------------------------------------------------------- U/L----------------------------------------------------------------------------------------------------------------------------------GROUP: 1000 PPM FEMALES 3672 19. 3683 13. 3690 24. 3697 20. 3706 15. MEAN 18. S.D. 4.3 S.E. 1.9 N 5---------------------------------------------------------------------------------------------------------------------------------- U/L = INTERNATIONAL UNIT/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 22 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TOTAL A/G TOTAL UREA CREAT- ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL ALBUMIN PROTEIN GLOBULIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER----------------------------------------------------------------------------------------------------------------------------------- g/dL g/dL g/dL mg/dL mg/dL mg/dL U/L U/L U/L U/L-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM FEMALES 3684 4.7 6.9 2.2 2.16 0.13 16.5 0.2 111. 37. 78. 0.3 3724 4.5 7.0 2.5 1.83 0.09 14.1 0.3 126. 41. 84. 0.4 3728 5.2 7.3 2.1 2.50 0.15 10.9 0.3 96. 45. 79. 0.4 3729 4.5 6.3 1.9 2.43 0.10 14.1 0.3 137. 31. 69. 0.2 3748 4.9 6.9 2.0 2.51 0.14 11.3 0.2 71. 31. 68. 0.6 MEAN 4.8 6.9 2.1 2.29 0.12 13.4 0.3 108. 37. 76. 0.4 S.D. 0.30 0.36 0.23 0.292 0.026 2.30 0.05 25.9 6.2 6.9 0.15 S.E. 0.13 0.16 0.10 0.130 0.012 1.03 0.02 11.6 2.8 3.1 0.07 N 5 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 23 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CHOL- PHOS- POTAS- TRIGLY- ANIMAL GLUCOSE ESTEROL CALCIUM CHLORIDE PHORUS SIUM SODIUM CERIDE----------------------------------------------------------------------------------------------------------------------------------- mg/dL mg/dL mg/dL mEq/L mg/dL mEq/L mEq/L mg/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM FEMALES 3684 120. 78. 10.8 102. 7.1 4.82 143. 66. 3724 104. 61. 10.7 104. 7.0 4.63 143. 48. 3728 131. 74. 11.3 102. 7.7 4.67 144. 53. 3729 132. 73. 10.7 105. 7.3 4.02 144. 39. 3748 114. 72. 11.3 104. 7.8 4.50 145. 47. MEAN 120. 72. 11.0 103. 7.4 4.53 144. 51. S.D. 11.8 6.3 0.31 1.3 0.36 0.306 0.8 10.0 S.E. 5.3 2.8 0.14 0.6 0.16 0.137 0.4 4.5 N 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 24 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3---------------------------------------------------------------------------------------------------------------------------------- SORBITOL ANIMAL 'GENASE---------------------------------------------------------------------------------------------------------------------------------- U/L----------------------------------------------------------------------------------------------------------------------------------GROUP: 1500 PPM FEMALES 3684 11. 3724 10. 3728 19. 3729 11. 3748 10. MEAN 12. S.D. 3.8 S.E. 1.7 N 5---------------------------------------------------------------------------------------------------------------------------------- U/L = INTERNATIONAL UNIT/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 25 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TOTAL A/G TOTAL UREA CREAT- ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL ALBUMIN PROTEIN GLOBULIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER----------------------------------------------------------------------------------------------------------------------------------- g/dL g/dL g/dL mg/dL mg/dL mg/dL U/L U/L U/L U/L-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM FEMALES 3682 4.8 7.1 2.3 2.12 0.14 12.9 0.3 125. 44. 68. 0.1 3705 4.5 6.7 2.2 2.06 0.12 15.6 0.3 157. 43. 91. 0.1 3710 4.9 7.1 2.1 2.32 0.13 11.5 0.4 142. 35. 77. 0.1 3740 4.5 6.5 2.0 2.25 0.13 12.6 0.3 122. 39. 81. 0.1 3749 4.8 7.2 2.4 2.03 0.11 12.4 0.3 120. 37. 77. 0.1 MEAN 4.7 6.9 2.2 2.16 0.13 13.0 0.3 133. 40. 79. 0.1 S.D. 0.19 0.30 0.16 0.125 0.011 1.54 0.04 15.9 3.8 8.3 0.00 S.E. 0.08 0.14 0.07 0.056 0.005 0.69 0.02 7.1 1.7 3.7 0.00 N 5 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 26 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CHOL- PHOS- POTAS- TRIGLY- ANIMAL GLUCOSE ESTEROL CALCIUM CHLORIDE PHORUS SIUM SODIUM CERIDE----------------------------------------------------------------------------------------------------------------------------------- mg/dL mg/dL mg/dL mEq/L mg/dL mEq/L mEq/L mg/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM FEMALES 3682 130. 105. 10.7 101. 6.7 4.96 140. 96. 3705 128. 63. 10.4 102. 7.4 4.46 144. 58. 3710 127. 62. 10.8 105. 7.5 4.05 146. 41. 3740 117. 82. 10.7 103. 6.8 4.45 143. 50. 3749 132. 73. 11.5 102. 8.8 5.16 145. 53. MEAN 127. 77. 10.8 103. 7.4 4.62 144. 60. S.D. 5.8 17.6 0.41 1.5 0.84 0.443 2.3 21.3 S.E. 2.6 7.9 0.18 0.7 0.37 0.198 1.0 9.5 N 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 27 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3---------------------------------------------------------------------------------------------------------------------------------- SORBITOL ANIMAL 'GENASE---------------------------------------------------------------------------------------------------------------------------------- U/L----------------------------------------------------------------------------------------------------------------------------------GROUP: 2000 PPM FEMALES 3682 12. 3705 19. 3710 20. 3740 14. 3749 21. MEAN 17. S.D. 4.0 S.E. 1.8 N 5---------------------------------------------------------------------------------------------------------------------------------- U/L = INTERNATIONAL UNIT/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 28 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TOTAL A/G TOTAL UREA CREAT- ALKALINE ALANINE ASPARTAT GLUTAMYL ANIMAL ALBUMIN PROTEIN GLOBULIN RATIO BILI NITROGEN ININE PHOS'TSE TRANSFER TRANSFER TRANSFER----------------------------------------------------------------------------------------------------------------------------------- g/dL g/dL g/dL mg/dL mg/dL mg/dL U/L U/L U/L U/L-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM FEMALES 3688 4.8 7.2 2.3 2.08 0.12 15.5 0.3 135. 60. 94. 0.1 3703 4.5 6.1 1.6 2.76 0.08 12.0 0.4 125. 47. 81. 0.1 3717 4.9 6.8 1.8 2.68 0.14 12.0 0.3 133. 34. 74. 0.1 3755 4.4 6.5 2.2 2.03 0.08 10.6 0.3 123. 50. 203. 0.4 3758 4.7 6.8 2.0 2.31 0.14 9.4 0.2 112. 38. 75. 0.1 MEAN 4.7 6.7 2.0 2.37 0.11 11.9 0.3 126. 46. 105. 0.2 S.D. 0.21 0.41 0.29 0.336 0.030 2.29 0.07 9.2 10.3 55.1 0.13 S.E. 0.09 0.18 0.13 0.150 0.014 1.02 0.03 4.1 4.6 24.7 0.06 N 5 5 5 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, U/L = INTERNATIONAL UNIT/LITER, g/dL = GRAMS/DECILITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 29 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CHOL- PHOS- POTAS- TRIGLY- ANIMAL GLUCOSE ESTEROL CALCIUM CHLORIDE PHORUS SIUM SODIUM CERIDE----------------------------------------------------------------------------------------------------------------------------------- mg/dL mg/dL mg/dL mEq/L mg/dL mEq/L mEq/L mg/dL-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM FEMALES 3688 123. 86. 11.0 103. 7.5 4.53 143. 44. 3703 152. 77. 10.8 106. 7.9 5.63 144. 60. 3717 123. 67. 10.6 103. 5.7 4.26 143. 49. 3755 148. 79. 10.5 105. 4.7 4.44 143. 48. 3758 115. 85. 10.9 105. 6.2 4.03 144. 50. MEAN 132. 79. 10.8 104. 6.4 4.58 143. 50. S.D. 16.6 7.6 0.21 1.3 1.31 0.618 0.5 5.9 S.E. 7.4 3.4 0.09 0.6 0.59 0.277 0.2 2.7 N 5 5 5 5 5 5 5 5----------------------------------------------------------------------------------------------------------------------------------- mg/dL = MILLIGRAMS/DECILITER, mEq/L = MILLIEQUIVALENTS/LITER

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 TABLE A10 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 30 INDIVIDUAL SERUM CHEMISTRY VALUES WEEK 3----------------------------------------------------------------------------------------------------------------------------------- SORBITOL ANIMAL 'GENASE----------------------------------------------------------------------------------------------------------------------------------- U/L-----------------------------------------------------------------------------------------------------------------------------------GROUP: 2500 PPM FEMALES 3688 17. 3703 24. 3717 11. 3755 13. 3758 12. MEAN 15. S.D. 5.3 S.E. 2.4 N 5----------------------------------------------------------------------------------------------------------------------------------- U/L = INTERNATIONAL UNIT/LITER PCHEv4.03 06/10/2009 R:06/10/2009

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3789 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LN, MANDIBULAR MICRO: NO SIGNIFICANT CHANGES OBSERVEDBRAIN 2.00 0.570 ONE NODE NOT PRESENT IN WET TISSUELIVER 9.96 2.838 LIVER MICRO: INFILTRATE, MONONUCLEAR 1KIDNEYS 3.03 0.863 LUNGS MICRO: HISTIOCYTOSIS, ALVEOLAR 1LUNGS 1.43 0.407 PANCREAS MICRO: INFILTRATE, MONONUCLEAR 1SPLEEN 0.51 0.145 THYMUS GROSS: AREA(S), DARK RED PHEART 1.20 0.342 MULTIPLE, IRREGULARLY SHAPEDEPIDIDYMIDES 1.10 0.313 ^==> THYMUS: HEMORRHAGETESTES 3.25 0.926 THYMUS MICRO: HEMORRHAGE 1ADRENAL GLANDS 0.0565 0.016 NASAL LEVEL IV MICRO: METAPLASIA, SQUAMOUS 1THYROIDS/PARATHY 0.0222 0.006 FOCAL, VENTRALFINAL BODY WT(G) 351. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LN, MESENTERIC NERVE, SCIATIC

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3789 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS PARATHYROIDS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3790 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. PROSTATE MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 2.00 0.556 NO SIGNIFICANTLIVER 10.57 2.936 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURKIDNEYS 2.45 0.681 JOINT BRAIN CECUM COLONLUNGS 1.32 0.367 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESSPLEEN 0.73 0.203 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMHEART 1.19 0.331 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOREPIDIDYMIDES 1.07 0.297 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICTESTES 3.10 0.861 PANCREAS PHARYNX PITUITARY PROSTATEADRENAL GLANDS 0.0608 0.017 RECTUM SPINAL CORD SAL. GLAND MAND STOMACHTHYROIDS/PARATHY 0.0211 0.006 SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLESFINAL BODY WT(G) 360. TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3791 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. NASAL LEVEL IV MICRO: METAPLASIA, SQUAMOUS 1BRAIN 1.90 0.546 FOCAL, VENTRALLIVER 9.82 2.822 NO SIGNIFICANTKIDNEYS 2.04 0.586 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURLUNGS 1.18 0.339 JOINT BRAIN CECUM COLONSPLEEN 0.48 0.138 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESHEART 1.24 0.356 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMEPIDIDYMIDES 1.06 0.305 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORTESTES 3.11 0.894 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICADRENAL GLANDS 0.0714 0.021 PANCREAS PHARYNX PITUITARY PROSTATETHYROIDS/PARATHY 0.0177 0.005 RECTUM SPINAL CORD SAL. GLAND MAND STOMACHFINAL BODY WT(G) 348. SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3802 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. EYES MICRO: INFLAMMATION, ACUTE 1BRAIN 2.21 0.533 NOTED IN PERIOCULAR TISSUESLIVER 12.50 3.012 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1KIDNEYS 2.80 0.675 LIVER MICRO: INFILTRATE, MONONUCLEAR 1LUNGS 1.48 0.357 NO SIGNIFICANTSPLEEN 0.77 0.186 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURHEART 1.57 0.378 JOINT BRAIN CECUM COLONEPIDIDYMIDES 1.10 0.265 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESTESTES 3.44 0.829 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMADRENAL GLANDS 0.0580 0.014 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORTHYROIDS/PARATHY 0.0240 0.006 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICFINAL BODY WT(G) 415. PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM LN, MANDIBULAR LAC. GLAND EXOR LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3802 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3811 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. HEART MICRO: CARDIOMYOPATHY 1BRAIN 1.95 0.562 HARDERIAN GLANDS MICRO: INFILTRATE, MONONUCLEAR 1LIVER 9.45 2.723 LIVER MICRO: INFILTRATE, MONONUCLEAR 1KIDNEYS 2.47 0.712 NO SIGNIFICANTLUNGS 1.34 0.386 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURSPLEEN 0.61 0.176 JOINT BRAIN CECUM COLONHEART 1.02 0.294 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESEPIDIDYMIDES 1.07 0.308 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMTESTES 3.18 0.916 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORADRENAL GLANDS 0.0427 0.012 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICTHYROIDS/PARATHY 0.0194 0.006 PANCREAS PHARYNX PITUITARY PROSTATEFINAL BODY WT(G) 347. RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3764 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT MICRO: NOT EXAMINED AS PER SOP 1BRAIN 1.86 0.478 MANDIBULAR LYMPH NODELIVER 11.10 2.853 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1KIDNEYS 2.77 0.712 LN, MANDIBULAR GROSS: DISCOLORATION, DARK RED PLUNGS 1.33 0.342 BILATERALSPLEEN 0.64 0.165 ^==> GENERAL COMMENT: NOT EXAMINED AS PER SOPHEART 1.37 0.352 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1EPIDIDYMIDES 1.20 0.308 WITH SCATTERED EOSINOPHILSTESTES 3.36 0.864 THYMUS GROSS: AREA(S), DARK RED PADRENAL GLANDS 0.0548 0.014 FEW, IRREGULARLY SHAPEDTHYROIDS/PARATHY 0.0150 0.004 ^==> THYMUS: HEMORRHAGEFINAL BODY WT(G) 389. THYMUS MICRO: HEMORRHAGE 1 NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:LIVER GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3801 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1BRAIN 1.83 0.480 LIVER MICRO: INFILTRATE, MONONUCLEAR 1LIVER 10.84 2.845 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1KIDNEYS 2.37 0.622 NO SIGNIFICANTLUNGS 1.40 0.367 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURSPLEEN 0.61 0.160 JOINT BRAIN CECUM COLONHEART 1.10 0.289 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESEPIDIDYMIDES 1.02 0.268 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMTESTES 3.23 0.848 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORADRENAL GLANDS 0.0597 0.016 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICTHYROIDS/PARATHY 0.0152 0.004 PANCREAS PHARYNX PITUITARY PROSTATEFINAL BODY WT(G) 381. RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3806 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 2.08 0.512 NO SIGNIFICANTLIVER 13.34 3.286 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURKIDNEYS 2.44 0.601 JOINT BRAIN CECUM COLONLUNGS 1.36 0.335 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESSPLEEN 0.64 0.158 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMHEART 1.58 0.389 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOREPIDIDYMIDES 1.07 0.264 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICTESTES 3.50 0.862 PANCREAS PHARYNX PITUITARY PROSTATEADRENAL GLANDS 0.0603 0.015 RECTUM SPINAL CORD SAL. GLAND MAND STOMACHTHYROIDS/PARATHY 0.0177 0.004 SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLESFINAL BODY WT(G) 406. TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3824 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. KIDNEYS GROSS: DILATED PELVIS 1BRAIN 1.96 0.491 RIGHTLIVER 11.68 2.927 ^==> KIDNEYS: DILATATION, PELVISKIDNEYS 2.49 0.624 KIDNEYS MICRO: DILATATION, PELVIS PLUNGS 1.32 0.331 LIVER MICRO: INFILTRATE, MONONUCLEAR 1SPLEEN 0.68 0.170 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1HEART 1.41 0.353 WITH SCATTERED EOSINOPHILSEPIDIDYMIDES 1.07 0.268 THYMUS GROSS: AREA(S), DARK RED PTESTES 3.59 0.900 MULTIPLE, PINPOINTADRENAL GLANDS 0.0607 0.015 ^==> THYMUS: HEMORRHAGETHYROIDS/PARATHY 0.0230 0.006 THYMUS MICRO: HEMORRHAGE 1FINAL BODY WT(G) 399. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3840 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 2.09 0.526 LUNGS MICRO: HISTIOCYTOSIS, ALVEOLAR 1LIVER 12.75 3.212 NO SIGNIFICANTKIDNEYS 2.73 0.688 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURLUNGS 1.47 0.370 JOINT BRAIN CECUM COLONSPLEEN 0.77 0.194 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESHEART 1.34 0.338 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMEPIDIDYMIDES 0.96 0.242 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORTESTES 3.04 0.766 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICADRENAL GLANDS 0.0582 0.015 PANCREAS PHARYNX PITUITARY PROSTATETHYROIDS/PARATHY 0.0257 0.006 RECTUM SPINAL CORD SAL. GLAND MAND STOMACHFINAL BODY WT(G) 397. SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3765 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANTBRAIN 1.92 0.526 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURLIVER 9.85 2.699 JOINT BRAIN CECUM COLONKIDNEYS 2.39 0.655 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESLUNGS 1.35 0.370 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMSPLEEN 0.79 0.216 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORHEART 1.53 0.419 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICEPIDIDYMIDES 1.14 0.312 PANCREAS PHARYNX PITUITARY PROSTATETESTES 3.32 0.910 RECTUM SPINAL CORD SAL. GLAND MAND STOMACHADRENAL GLANDS 0.0806 0.022 SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLESTHYROIDS/PARATHY 0.0180 0.005 TESTES PEYER'S PATCHES THYROID GLANDS THYMUSFINAL BODY WT(G) 365. TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LIVER LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3766 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: ORGAN DAMAGED AT NECROPSY PBRAIN 2.06 0.519 FEMUR, RIGHT; TIBIOFEMORAL JOINT, RIGHTLIVER 11.63 2.929 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1KIDNEYS 2.46 0.620 LIVER MICRO: INFILTRATE, MONONUCLEAR 1LUNGS 1.43 0.360 NO SIGNIFICANTSPLEEN 0.69 0.174 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURHEART 1.47 0.370 JOINT BRAIN CECUM COLONEPIDIDYMIDES 1.12 0.282 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESTESTES 3.14 0.791 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMADRENAL GLANDS 0.0515 0.013 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORTHYROIDS/PARATHY 0.0183 0.005 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICFINAL BODY WT(G) 397. PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3777 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANTBRAIN 2.09 0.584 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURLIVER 10.71 2.992 JOINT BRAIN CECUM COLONKIDNEYS 2.22 0.620 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESLUNGS 1.29 0.360 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMSPLEEN 0.55 0.154 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORHEART 1.26 0.352 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICEPIDIDYMIDES 0.97 0.271 PANCREAS PHARYNX PITUITARY PROSTATETESTES 2.84 0.793 RECTUM SPINAL CORD SAL. GLAND MAND STOMACHADRENAL GLANDS 0.0689 0.019 SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLESTHYROIDS/PARATHY 0.0180 0.005 TESTES PEYER'S PATCHES THYROID GLANDS THYMUSFINAL BODY WT(G) 358. TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LIVER LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3778 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1BRAIN 2.01 0.496 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1LIVER 13.17 3.252 WITH EOSINOPHILS AND HEMOGLOBIN CRYSTALSKIDNEYS 2.79 0.689 HISTIOCYTOSIS, ALVEOLAR 1LUNGS 1.55 0.383 NO SIGNIFICANTSPLEEN 0.84 0.207 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURHEART 1.45 0.358 JOINT BRAIN CECUM COLONEPIDIDYMIDES 1.26 0.311 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESTESTES 3.57 0.881 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMADRENAL GLANDS 0.0787 0.019 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORTHYROIDS/PARATHY 0.0211 0.005 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICFINAL BODY WT(G) 405. PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:LIVER GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3798 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. KIDNEYS GROSS: CYST(S) PBRAIN 1.89 0.654 ONE, 1 MM IN DIAMETER, IN CORTEX, RIGHTLIVER 8.89 3.076 ^==> KIDNEYS: NEPHROPATHY, CHRONIC PROGRESSIVEKIDNEYS 2.13 0.737 KIDNEYS GROSS: AREA(S), DEPRESSED PLUNGS 1.16 0.401 FEW, IRREGULARLY SHAPED, IN CORTEX, BILATERALSPLEEN 0.51 0.176 ^==> KIDNEYS: NEPHROPATHY, CHRONIC PROGRESSIVEHEART 1.00 0.346 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1EPIDIDYMIDES 1.04 0.360 WITH SUBCAPSULAR FIBROSIS AND MONONUCLEAR INFILTRATESTESTES 2.95 1.021 LIVER MICRO: INFILTRATE, MONONUCLEAR 1ADRENAL GLANDS 0.0378 0.013 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1THYROIDS/PARATHY 0.0182 0.006 WITH SCATTERED EOSINOPHILSFINAL BODY WT(G) 289. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3792 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: ORGAN DAMAGED AT NECROPSY PBRAIN 2.20 0.470 BRAINLIVER 15.55 3.323 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1KIDNEYS 3.17 0.677 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1LUNGS 1.51 0.323 WITH SCATTERED EOSINOPHILSSPLEEN 0.82 0.175 THYMUS GROSS: AREA(S), DARK RED PHEART 1.72 0.368 MULTIPLE, IRREGULARLY SHAPEDEPIDIDYMIDES 1.26 0.269 ^==> THYMUS: HEMORRHAGETESTES 3.86 0.825 THYMUS MICRO: HEMORRHAGE 1ADRENAL GLANDS 0.0584 0.012 NO SIGNIFICANTTHYROIDS/PARATHY 0.0255 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURFINAL BODY WT(G) 468. JOINT BRAIN CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:LIVER GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3799 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANTBRAIN 1.96 0.566 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURLIVER 10.20 2.948 JOINT BRAIN CECUM COLONKIDNEYS 2.30 0.665 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESLUNGS 1.28 0.370 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMSPLEEN 0.54 0.156 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORHEART 1.11 0.321 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICEPIDIDYMIDES 1.12 0.324 PANCREAS PHARYNX PITUITARY PROSTATETESTES 3.50 1.012 RECTUM SPINAL CORD SAL. GLAND MAND STOMACHADRENAL GLANDS 0.0537 0.016 SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLESTHYROIDS/PARATHY 0.0208 0.006 TESTES PEYER'S PATCHES THYROID GLANDS THYMUSFINAL BODY WT(G) 346. TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LIVER LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3809 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LUNGS MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 1.84 0.564 WITH SCATTERED EOSINOPHILSLIVER 10.28 3.153 NO SIGNIFICANTKIDNEYS 2.13 0.653 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURLUNGS 1.36 0.417 JOINT BRAIN CECUM COLONSPLEEN 0.56 0.172 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESHEART 0.99 0.304 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMEPIDIDYMIDES 1.05 0.322 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORTESTES 3.09 0.948 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICADRENAL GLANDS 0.0629 0.019 PANCREAS PHARYNX PITUITARY PROSTATETHYROIDS/PARATHY 0.0147 0.005 RECTUM SPINAL CORD SAL. GLAND MAND STOMACHFINAL BODY WT(G) 326. SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LIVER GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 21 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3812 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANTBRAIN 2.08 0.547 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURLIVER 10.65 2.803 JOINT BRAIN CECUM COLONKIDNEYS 2.52 0.663 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESLUNGS 1.37 0.361 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMSPLEEN 0.58 0.153 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORHEART 1.20 0.316 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICEPIDIDYMIDES 1.11 0.292 PANCREAS PHARYNX PITUITARY PROSTATETESTES 3.44 0.905 RECTUM SPINAL CORD SAL. GLAND MAND STOMACHADRENAL GLANDS 0.0515 0.014 SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLESTHYROIDS/PARATHY 0.0197 0.005 TESTES PEYER'S PATCHES THYROID GLANDS THYMUSFINAL BODY WT(G) 380. TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LIVER LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 22 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3815 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 1.97 0.646 NO SIGNIFICANTLIVER 8.20 2.689 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURKIDNEYS 2.36 0.774 JOINT BRAIN CECUM COLONLUNGS 1.10 0.361 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESSPLEEN 0.63 0.207 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMHEART 1.03 0.338 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOREPIDIDYMIDES 0.98 0.321 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICTESTES 3.06 1.003 PANCREAS PHARYNX PITUITARY PROSTATEADRENAL GLANDS 0.0455 0.015 RECTUM SPINAL CORD SAL. GLAND MAND STOMACHTHYROIDS/PARATHY 0.0153 0.005 SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLESFINAL BODY WT(G) 305. TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 23 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3783 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. HARDERIAN GLANDS MICRO: HEMORRHAGE 1BRAIN 2.01 0.546 WITH NEUTROPHIL INFILTRATES, UNILATERAL; CONSIDERED SECONDARYLIVER 10.63 2.889 TO BLOOD COLLECTIONKIDNEYS 2.33 0.633 LN, MANDIBULAR MICRO: NO SIGNIFICANT CHANGES OBSERVEDLUNGS 1.30 0.353 ONE NODE NOT PRESENT IN WET TISSUESPLEEN 0.51 0.139 LIVER MICRO: INFILTRATE, MONONUCLEAR 1HEART 1.18 0.321 LUNGS MICRO: HISTIOCYTOSIS, ALVEOLAR 1EPIDIDYMIDES 0.99 0.269 PARATHYROIDS MICRO: NO SIGNIFICANT CHANGES OBSERVEDTESTES 3.03 0.823 ONE GLAND NOT IN PLANE OF SECTION, 2 SECTIONS EXAMINEDADRENAL GLANDS 0.0618 0.017 NO SIGNIFICANTTHYROIDS/PARATHY 0.0184 0.005 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURFINAL BODY WT(G) 368. JOINT BRAIN CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LN, MESENTERIC NERVE, SCIATIC PANCREAS

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 24 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3783 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 25 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3785 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. HEART MICRO: CARDIOMYOPATHY 1BRAIN 2.09 0.537 LN, MANDIBULAR GROSS: DISCOLORATION, DARK RED PLIVER 10.92 2.807 BILATERALKIDNEYS 2.62 0.674 ^==> LN, MANDIBULAR: HEMORRHAGELUNGS 1.30 0.334 LN, MANDIBULAR MICRO: HEMORRHAGE 1SPLEEN 0.65 0.167 PARATHYROIDS MICRO: NO SIGNIFICANT CHANGES OBSERVEDHEART 1.35 0.347 ONE GLAND NOT IN PLANE OF SECTION, 2 SECTIONS EXAMINEDEPIDIDYMIDES 1.09 0.280 THYMUS GROSS: AREA(S), DARK RED PTESTES 3.05 0.784 MULTIPLE, IRREGULARLY SHAPEDADRENAL GLANDS 0.0569 0.015 ^==> THYMUS: HEMORRHAGETHYROIDS/PARATHY 0.0191 0.005 THYMUS MICRO: HEMORRHAGE 1FINAL BODY WT(G) 389. NASAL LEVEL I MICRO: INFILTRATE, NEUTROPHIL 1 FOCAL NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HARDERIAN GLANDS

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 26 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3785 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- ILEUM JEJUNUM KIDNEYS LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS PARATHYROIDS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 27 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3807 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: ORGAN DAMAGED AT NECROPSY PBRAIN 2.07 0.577 BRAINLIVER 9.87 2.749 LIVER MICRO: INFILTRATE, MONONUCLEAR 1KIDNEYS 2.59 0.721 NO SIGNIFICANTLUNGS 1.27 0.354 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURSPLEEN 0.72 0.201 JOINT BRAIN CECUM COLONHEART 1.04 0.290 DUODENUM EPIDIDYMIDES ESOPHAGUS EYESEPIDIDYMIDES 1.07 0.298 NERVES, OPTIC HEART HARDERIAN GLANDS ILEUMTESTES 3.16 0.880 JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXORADRENAL GLANDS 0.0712 0.020 LIVER LN, MESENTERIC LUNGS NERVE, SCIATICTHYROIDS/PARATHY 0.0184 0.005 PANCREAS PHARYNX PITUITARY PROSTATEFINAL BODY WT(G) 359. RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 28 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3810 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 2.02 0.592 SKELETAL MUSCLE MICRO: INFILTRATE, MONONUCLEAR 1LIVER 10.19 2.988 FOCALKIDNEYS 2.42 0.710 TESTES MICRO: ATROPHY 1LUNGS 1.48 0.434 FOCALSPLEEN 0.64 0.188 NASAL LEVEL I MICRO: INFILTRATE, NEUTROPHIL 1HEART 1.26 0.370 FOCALEPIDIDYMIDES 1.13 0.331 METAPLASIA, SQUAMOUS 1TESTES 3.52 1.032 NOTED IN ASSOCIATION WITH NEUTROPHIL INFILTRATEADRENAL GLANDS 0.0562 0.016 NASAL LEVEL IV MICRO: METAPLASIA, SQUAMOUS 1THYROIDS/PARATHY 0.0213 0.006 FOCAL, VENTRALFINAL BODY WT(G) 341. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM EPIDIDYMIDES

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 29 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3810 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKIN SPLEEN SEMINAL VESICLES PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL II NASAL LEVEL III NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 30 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3831 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. HEART MICRO: CARDIOMYOPATHY 1BRAIN 2.02 0.639 LIVER MICRO: INFILTRATE, MONONUCLEAR 1LIVER 7.74 2.449 TESTES MICRO: ATROPHY 1KIDNEYS 2.26 0.715 THYMUS GROSS: AREA(S), DARK RED PLUNGS 1.20 0.380 MULTIPLE, IRREGULARLY SHAPEDSPLEEN 0.60 0.190 ^==> THYMUS: HEMORRHAGEHEART 1.00 0.316 THYMUS MICRO: HEMORRHAGE 1EPIDIDYMIDES 0.95 0.301 NASAL LEVEL I MICRO: PERIODONTITIS 2TESTES 3.04 0.962 NASAL LEVEL II MICRO: HYPERPLASIA, GOBLET CELL 1ADRENAL GLANDS 0.0696 0.022 VENTRALTHYROIDS/PARATHY 0.0153 0.005 NASAL LEVEL III MICRO: INFLAMMATION, ACUTE 2FINAL BODY WT(G) 316. ASSOCIATED WITH TOOTH NASAL LEVEL IV MICRO: INFLAMMATION, ACUTE 2 ASSOCIATED WITH TOOTH NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 31 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3831 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES PEYER'S PATCHES THYROID GLANDS PARATHYROIDS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 32 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3691 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1BRAIN 1.83 0.625 PITUITARY MICRO: NO SIGNIFICANT CHANGES OBSERVEDLIVER 8.65 2.952 PARS NERVOSA NOT PRESENTKIDNEYS 1.96 0.669 VAGINA MICRO: ESTROUS CYCLE: PROESTRUS PLUNGS 1.24 0.423 LARYNX MICRO: INFILTRATE, MONONUCLEAR 2SPLEEN 0.65 0.222 LN, MEDIASTINAL MICRO: HEMORRHAGE 1HEART 1.12 0.382 NO SIGNIFICANTOVARIES/OVIDUCTS 0.1244 0.042 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURADRENAL GLANDS 0.0761 0.026 JOINT BRAIN CECUM COLONTHYROIDS/PARATHY 0.0194 0.007 DUODENUM ESOPHAGUS EYES NERVES, OPTICFINAL BODY WT(G) 293. HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 33 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3691 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- UTERUS CERVIX LN, AXILLARY LN, BRONCHIAL NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 34 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3693 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. KIDNEYS MICRO: MINERALIZATION, MEDULLARY 1BRAIN 1.82 0.734 LIVER MICRO: INFILTRATE, MONONUCLEAR 1LIVER 7.57 3.052 VAGINA MICRO: ESTROUS CYCLE: DIESTRUS PKIDNEYS 1.72 0.694 NO SIGNIFICANTLUNGS 1.16 0.468 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURSPLEEN 0.48 0.194 JOINT BRAIN CECUM COLONHEART 0.88 0.355 DUODENUM ESOPHAGUS EYES NERVES, OPTICOVARIES/OVIDUCTS 0.1595 0.064 HEART HARDERIAN GLANDS ILEUM JEJUNUMADRENAL GLANDS 0.0779 0.031 KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVERTHYROIDS/PARATHY 0.0175 0.007 LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATICFINAL BODY WT(G) 248. OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM LN, MANDIBULAR LAC. GLAND EXOR LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER UTERUS CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 35 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3719 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. HEART MICRO: CARDIOMYOPATHY 1BRAIN 1.94 0.836 VAGINA MICRO: ESTROUS CYCLE: DIESTRUS PLIVER 6.64 2.862 LN, MEDIASTINAL MICRO: HEMORRHAGE 1KIDNEYS 1.91 0.823 LN, BRONCHIAL MICRO: HEMORRHAGE 1LUNGS 1.10 0.474 NASAL LEVEL I MICRO: INFILTRATE, MIXED INFLAMMATORY CELL 1SPLEEN 0.48 0.207 CHARACTERIZED BY MIXED MONONUCLEAR CELLS AND NEUTROPHILSHEART 0.84 0.362 METAPLASIA, SQUAMOUS 1OVARIES/OVIDUCTS 0.1262 0.054 NO SIGNIFICANTADRENAL GLANDS 0.0622 0.027 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURTHYROIDS/PARATHY 0.0189 0.008 JOINT BRAIN CECUM COLONFINAL BODY WT(G) 232. DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 36 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3719 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- PARATHYROIDS THYMUS TRACHEA URINARY BLADDER UTERUS CERVIX LARYNX LN, AXILLARY NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 37 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3723 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. EYES MICRO: NO SIGNIFICANT CHANGES OBSERVEDBRAIN 1.90 0.809 ONE OPTIC NERVE MISSING, 2 SECTIONS EVALUATEDLIVER 6.18 2.630 KIDNEYS MICRO: NEPHROPATHY, CHRONIC PROGRESSIVE 1KIDNEYS 1.67 0.711 VAGINA MICRO: ESTROUS CYCLE: PROESTRUS PLUNGS 1.15 0.489 LN, BRONCHIAL MICRO: NOT PRESENT FOR EXAMINATIONSPLEEN 0.54 0.230 NOT PRESENT IN WET TISSUEHEART 0.86 0.366 NASAL LEVEL I MICRO: INFILTRATE, MIXED INFLAMMATORY CELL 1OVARIES/OVIDUCTS 0.1342 0.057 HYPERPLASIA, GOBLET CELL 1ADRENAL GLANDS 0.0641 0.027 FOCAL, ASSOCIATED WITH INFILTRATETHYROIDS/PARATHY 0.0153 0.007 NO SIGNIFICANTFINAL BODY WT(G) 235. CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 38 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3723 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER UTERUS CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI NOT PRESENT FOR EXAMINATION MICRO:LN, BRONCHIAL GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 39 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3733 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 2.01 0.677 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1LIVER 8.53 2.872 PITUITARY MICRO: NO SIGNIFICANT CHANGES OBSERVEDKIDNEYS 2.06 0.694 PARS NERVOSA NOT PRESENTLUNGS 1.17 0.394 SAL. GLAND MAND MICRO: INFILTRATE, MONONUCLEAR 1SPLEEN 0.70 0.236 PARATHYROIDS MICRO: NO SIGNIFICANT CHANGES OBSERVEDHEART 1.12 0.377 ONE GLAND NOT IN PLANE OF SECTION, 2 SECTIONS EXAMINEDOVARIES/OVIDUCTS 0.1506 0.051 VAGINA MICRO: ESTROUS CYCLE: ESTRUS PADRENAL GLANDS 0.0866 0.029 NASAL LEVEL I MICRO: INFLAMMATION, ACUTE 1THYROIDS/PARATHY 0.0177 0.006 FOCALFINAL BODY WT(G) 297. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 40 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3733 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- LAC. GLAND EXOR LN, MESENTERIC MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER UTERUS CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 41 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3672 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT MICRO: NOT EXAMINED AS PER SOP PBRAIN 1.88 0.803 MANDIBULAR LYMPH NODELIVER 6.59 2.816 LN, MANDIBULAR GROSS: DISCOLORATION, DARK RED PKIDNEYS 1.68 0.718 BILATERALLUNGS 0.92 0.393 ^==> GENERAL COMMENT: NOT EXAMINED AS PER SOPSPLEEN 0.56 0.239 LIVER MICRO: INFILTRATE, MONONUCLEAR 1HEART 0.81 0.346 LUNGS MICRO: HISTIOCYTOSIS, ALVEOLAR 1OVARIES/OVIDUCTS 0.1434 0.061 NO SIGNIFICANTADRENAL GLANDS 0.0631 0.027 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURTHYROIDS/PARATHY 0.0115 0.005 JOINT BRAIN CECUM COLONFINAL BODY WT(G) 234. DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 42 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3683 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. KIDNEYS MICRO: MINERALIZATION, MEDULLARY 1BRAIN 1.91 0.793 INCREASED ABOVE BACKGROUNDLIVER 6.24 2.589 LIVER MICRO: INFILTRATE, MONONUCLEAR 1KIDNEYS 1.68 0.697 NO SIGNIFICANTLUNGS 1.03 0.427 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURSPLEEN 0.48 0.199 JOINT BRAIN CECUM COLONHEART 0.87 0.361 DUODENUM ESOPHAGUS EYES NERVES, OPTICOVARIES/OVIDUCTS 0.1233 0.051 HEART HARDERIAN GLANDS ILEUM JEJUNUMADRENAL GLANDS 0.0667 0.028 KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVERTHYROIDS/PARATHY 0.0194 0.008 LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATICFINAL BODY WT(G) 241. OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 43 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3690 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 1.87 0.874 NECROSIS 1LIVER 5.75 2.687 FOCALKIDNEYS 1.70 0.794 UTERUS GROSS: CONTENTS, CLEAR FLUID PLUNGS 0.93 0.435 BOTH HORNSSPLEEN 0.44 0.206 ^==> UTERUS: DILATATION, LUMENHEART 0.88 0.411 UTERUS MICRO: DILATATION, LUMEN 3OVARIES/OVIDUCTS 0.1037 0.048 VAGINA MICRO: ESTROUS CYCLE: ESTRUS PADRENAL GLANDS 0.0681 0.032 NO SIGNIFICANTTHYROIDS/PARATHY 0.0158 0.007 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURFINAL BODY WT(G) 214. JOINT BRAIN CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 44 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3697 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. KIDNEYS MICRO: MINERALIZATION, MEDULLARY 2BRAIN 1.83 0.709 CYST PLIVER 7.86 3.047 MEDULLARY TUBULES, FOCALKIDNEYS 1.88 0.729 NEPHROPATHY, CHRONIC PROGRESSIVE 1LUNGS 1.11 0.430 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1SPLEEN 0.48 0.186 WITH SCATTERED EOSINOPHILSHEART 0.92 0.357 NO SIGNIFICANTOVARIES/OVIDUCTS 0.1478 0.057 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURADRENAL GLANDS 0.0606 0.023 JOINT BRAIN CECUM COLONTHYROIDS/PARATHY 0.0174 0.007 DUODENUM ESOPHAGUS EYES NERVES, OPTICFINAL BODY WT(G) 258. HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:LIVER GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 45 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3706 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 1.79 0.814 NO SIGNIFICANTLIVER 6.45 2.932 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURKIDNEYS 1.69 0.768 JOINT BRAIN CECUM COLONLUNGS 1.03 0.468 DUODENUM ESOPHAGUS EYES NERVES, OPTICSPLEEN 0.52 0.236 HEART HARDERIAN GLANDS ILEUM JEJUNUMHEART 0.86 0.391 KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVEROVARIES/OVIDUCTS 0.1025 0.047 LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATICADRENAL GLANDS 0.0569 0.026 OVIDUCTS OVARIES PANCREAS PHARYNXTHYROIDS/PARATHY 0.0163 0.007 PITUITARY RECTUM SPINAL CORD SAL. GLAND MANDFINAL BODY WT(G) 220. STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 46 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3684 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 1.88 0.743 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1LIVER 7.77 3.071 WITH EOSINOPHILS AND HEMOGLOBIN CRYSTALSKIDNEYS 1.61 0.636 NO SIGNIFICANTLUNGS 1.17 0.462 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURSPLEEN 0.54 0.213 JOINT BRAIN CECUM COLONHEART 1.30 0.514 DUODENUM ESOPHAGUS EYES NERVES, OPTICOVARIES/OVIDUCTS 0.1359 0.054 HEART HARDERIAN GLANDS ILEUM JEJUNUMADRENAL GLANDS 0.0755 0.030 KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVERTHYROIDS/PARATHY 0.0173 0.007 LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATICFINAL BODY WT(G) 253. OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 47 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3724 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 1.83 0.698 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1LIVER 7.35 2.805 WITH SCATTERED EOSINOPHILSKIDNEYS 1.77 0.676 LN, AXILLARY GROSS: ENLARGED PLUNGS 0.98 0.374 RIGHTSPLEEN 0.55 0.210 ^==> GROSS UNCONFIRMEDHEART 0.87 0.332 NO SIGNIFICANTOVARIES/OVIDUCTS 0.1345 0.051 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURADRENAL GLANDS 0.0721 0.028 JOINT BRAIN CECUM COLONTHYROIDS/PARATHY 0.0150 0.006 DUODENUM ESOPHAGUS EYES NERVES, OPTICFINAL BODY WT(G) 262. HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LN, AXILLARY GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 48 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3728 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: ORGAN DAMAGED AT NECROPSY PBRAIN 2.00 0.797 EYE, LEFTLIVER 7.42 2.956 LIVER MICRO: INFILTRATE, MONONUCLEAR 1KIDNEYS 1.87 0.745 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1LUNGS 1.09 0.434 WITH SCATTERED EOSINOPHILSSPLEEN 0.57 0.227 NO SIGNIFICANTHEART 1.02 0.406 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUROVARIES/OVIDUCTS 0.1345 0.054 JOINT BRAIN CECUM COLONADRENAL GLANDS 0.0680 0.027 DUODENUM ESOPHAGUS EYES NERVES, OPTICTHYROIDS/PARATHY 0.0173 0.007 HEART HARDERIAN GLANDS ILEUM JEJUNUMFINAL BODY WT(G) 251. KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 49 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3729 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 2.01 0.776 FOCALLIVER 7.85 3.031 NO SIGNIFICANTKIDNEYS 1.92 0.741 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURLUNGS 1.10 0.425 JOINT BRAIN CECUM COLONSPLEEN 0.64 0.247 DUODENUM ESOPHAGUS EYES NERVES, OPTICHEART 0.90 0.347 HEART HARDERIAN GLANDS ILEUM JEJUNUMOVARIES/OVIDUCTS 0.1381 0.053 KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVERADRENAL GLANDS 0.0762 0.029 LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATICTHYROIDS/PARATHY 0.0220 0.008 OVIDUCTS OVARIES PANCREAS PHARYNXFINAL BODY WT(G) 259. PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 50 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3748 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 1.96 0.824 NO SIGNIFICANTLIVER 7.43 3.122 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURKIDNEYS 1.83 0.769 JOINT BRAIN CECUM COLONLUNGS 1.17 0.492 DUODENUM ESOPHAGUS EYES NERVES, OPTICSPLEEN 0.53 0.223 HEART HARDERIAN GLANDS ILEUM JEJUNUMHEART 0.88 0.370 KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVEROVARIES/OVIDUCTS 0.1417 0.060 LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATICADRENAL GLANDS 0.0671 0.028 OVIDUCTS OVARIES PANCREAS PHARYNXTHYROIDS/PARATHY 0.0177 0.007 PITUITARY RECTUM SPINAL CORD SAL. GLAND MANDFINAL BODY WT(G) 238. STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 51 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3682 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 1.95 0.789 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1LIVER 7.80 3.158 WITH SCATTERED EOSINOPHILSKIDNEYS 1.61 0.652 NO SIGNIFICANTLUNGS 1.06 0.429 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURSPLEEN 0.44 0.178 JOINT BRAIN CECUM COLONHEART 1.01 0.409 DUODENUM ESOPHAGUS EYES NERVES, OPTICOVARIES/OVIDUCTS 0.1715 0.069 HEART HARDERIAN GLANDS ILEUM JEJUNUMADRENAL GLANDS 0.0495 0.020 KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVERTHYROIDS/PARATHY 0.0127 0.005 LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATICFINAL BODY WT(G) 247. OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 52 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3705 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. NO SIGNIFICANTBRAIN 1.93 0.928 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURLIVER 5.95 2.861 JOINT BRAIN CECUM COLONKIDNEYS 1.61 0.774 DUODENUM ESOPHAGUS EYES NERVES, OPTICLUNGS 1.04 0.500 HEART HARDERIAN GLANDS ILEUM JEJUNUMSPLEEN 0.42 0.202 KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVERHEART 0.83 0.399 LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATICOVARIES/OVIDUCTS 0.1136 0.055 OVIDUCTS OVARIES PANCREAS PHARYNXADRENAL GLANDS 0.0643 0.031 PITUITARY RECTUM SPINAL CORD SAL. GLAND MANDTHYROIDS/PARATHY 0.0165 0.008 STOMACH SKELETAL MUSCLE SKIN SPLEENFINAL BODY WT(G) 208. PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LIVER LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 53 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3710 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 1.84 0.760 NO SIGNIFICANTLIVER 7.45 3.079 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURKIDNEYS 1.90 0.785 JOINT BRAIN CECUM COLONLUNGS 1.25 0.517 DUODENUM ESOPHAGUS EYES NERVES, OPTICSPLEEN 0.41 0.169 HEART HARDERIAN GLANDS ILEUM JEJUNUMHEART 0.92 0.380 KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVEROVARIES/OVIDUCTS 0.1434 0.059 LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATICADRENAL GLANDS 0.0716 0.030 OVIDUCTS OVARIES PANCREAS PHARYNXTHYROIDS/PARATHY 0.0233 0.010 PITUITARY RECTUM SPINAL CORD SAL. GLAND MANDFINAL BODY WT(G) 242. STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 54 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3740 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 2.01 0.814 NO SIGNIFICANTLIVER 8.04 3.255 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURKIDNEYS 1.68 0.680 JOINT BRAIN CECUM COLONLUNGS 1.05 0.425 DUODENUM ESOPHAGUS EYES NERVES, OPTICSPLEEN 0.53 0.215 HEART HARDERIAN GLANDS ILEUM JEJUNUMHEART 0.88 0.356 KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVEROVARIES/OVIDUCTS 0.1351 0.055 LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATICADRENAL GLANDS 0.0686 0.028 OVIDUCTS OVARIES PANCREAS PHARYNXTHYROIDS/PARATHY 0.0197 0.008 PITUITARY RECTUM SPINAL CORD SAL. GLAND MANDFINAL BODY WT(G) 247. STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 55 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3749 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT MICRO: NOT EXAMINED AS PER SOP PBRAIN 1.96 0.775 MANDIBULAR LYMPH NODELIVER 7.63 3.016 LN, MANDIBULAR GROSS: DISCOLORATION, DARK RED PKIDNEYS 1.83 0.723 BILATERALLUNGS 1.10 0.435 ^==> GENERAL COMMENT: NOT EXAMINED AS PER SOPSPLEEN 0.39 0.154 LIVER MICRO: INFILTRATE, MONONUCLEAR 1HEART 1.07 0.423 NO SIGNIFICANTOVARIES/OVIDUCTS 0.1472 0.058 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURADRENAL GLANDS 0.0767 0.030 JOINT BRAIN CECUM COLONTHYROIDS/PARATHY 0.0140 0.006 DUODENUM ESOPHAGUS EYES NERVES, OPTICFINAL BODY WT(G) 253. HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:KIDNEYS LUNGS GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 56 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3688 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 1.95 0.762 SKIN GROSS: HAIR LOSS PLIVER 7.96 3.109 HINDLIMB, BILATERAL; LATERAL ABDOMINAL, BILATERAL; ENTIREKIDNEYS 1.68 0.656 VENTRAL SURFACE; CEO HAIR LOSSLUNGS 1.21 0.473 ^==> GROSS UNCONFIRMEDSPLEEN 0.49 0.191 VAGINA MICRO: ESTROUS CYCLE: DIESTRUS PHEART 0.82 0.320 LN, AXILLARY GROSS: ENLARGED POVARIES/OVIDUCTS 0.1260 0.049 BILATERALADRENAL GLANDS 0.0782 0.031 ^==> GROSS UNCONFIRMEDTHYROIDS/PARATHY 0.0157 0.006 LN, MEDIASTINAL MICRO: HEMORRHAGE 1FINAL BODY WT(G) 256. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 57 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3688 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER UTERUS CERVIX LARYNX LN, AXILLARY LN, BRONCHIAL NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 58 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3703 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. VAGINA MICRO: ESTROUS CYCLE: PROESTRUS PBRAIN 1.78 0.828 LARYNX MICRO: NO SIGNIFICANT CHANGES OBSERVEDLIVER 7.07 3.288 ANTERIOR SECTION NOT PRESENT IN REEMBEDDED BLOCKKIDNEYS 1.50 0.698 LN, BRONCHIAL MICRO: NOT PRESENT FOR EXAMINATIONLUNGS 0.89 0.414 NOT PRESENT IN WET TISSUESPLEEN 0.38 0.177 NO SIGNIFICANTHEART 0.83 0.386 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUROVARIES/OVIDUCTS 0.1000 0.047 JOINT BRAIN CECUM COLONADRENAL GLANDS 0.0502 0.023 DUODENUM ESOPHAGUS EYES NERVES, OPTICTHYROIDS/PARATHY 0.0146 0.007 HEART HARDERIAN GLANDS ILEUM JEJUNUMFINAL BODY WT(G) 215. KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 59 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3703 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- URINARY BLADDER UTERUS CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI NOT PRESENT FOR EXAMINATION MICRO:LN, BRONCHIAL GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 60 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3717 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. EYES MICRO: NO SIGNIFICANT CHANGES OBSERVEDBRAIN 1.81 0.866 ONE OPTIC NERVE MISSING, 2 SECTIONS EVALUATEDLIVER 6.67 3.191 LIVER MICRO: INFILTRATE, MONONUCLEAR 1KIDNEYS 1.67 0.799 PARATHYROIDS MICRO: NO SIGNIFICANT CHANGES OBSERVEDLUNGS 1.05 0.502 ONE GLAND NOT IN PLANE OF SECTION, 2 SECTIONS EXAMINEDSPLEEN 0.33 0.158 VAGINA MICRO: ESTROUS CYCLE: DIESTRUS PHEART 0.77 0.368 LN, MEDIASTINAL MICRO: HEMORRHAGE 1OVARIES/OVIDUCTS 0.1553 0.074 LN, BRONCHIAL MICRO: NOT PRESENT FOR EXAMINATIONADRENAL GLANDS 0.0542 0.026 NOT PRESENT IN SUPPLEMENTAL BLOCKS AND RECUTSTHYROIDS/PARATHY 0.0151 0.007 NO SIGNIFICANTFINAL BODY WT(G) 209. CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LN, MESENTERIC LUNGS MAMMARY GLAND

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 61 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3717 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER UTERUS CERVIX LARYNX LN, AXILLARY NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI NOT PRESENT FOR EXAMINATION MICRO:LN, BRONCHIAL GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 62 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3755 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. GENERAL COMMENT GROSS: ORGAN DAMAGED AT NECROPSY PBRAIN 2.10 0.854 UTERUS, RIGHT HORNLIVER 8.11 3.297 LUNGS MICRO: INFILTRATE, MONONUCLEAR 1KIDNEYS 1.65 0.671 WITH SCATTERED EOSINOPHILSLUNGS 1.20 0.488 PARATHYROIDS MICRO: NO SIGNIFICANT CHANGES OBSERVEDSPLEEN 0.49 0.199 ONE GLAND NOT IN PLANE OF SECTION, 2 SECTIONS EXAMINEDHEART 1.20 0.488 VAGINA GROSS: CYST(S) POVARIES/OVIDUCTS 0.1452 0.059 ONE, 22 X 12 X 12 MMADRENAL GLANDS 0.0694 0.028 ^==> GROSS UNCONFIRMEDTHYROIDS/PARATHY 0.0138 0.006 VAGINA MICRO: ESTROUS CYCLE: DIESTRUS PFINAL BODY WT(G) 246. NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS

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 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 63 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3755 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER UTERUS CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 64 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3758 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) REL. LIVER MICRO: INFILTRATE, MONONUCLEAR 1BRAIN 1.87 0.786 OVARIES MICRO: CYST PLIVER 7.73 3.248 UTERUS GROSS: CONTENTS, CLEAR FLUID PKIDNEYS 1.94 0.815 BOTH HORNSLUNGS 1.11 0.466 ^==> UTERUS: DILATATION, LUMENSPLEEN 0.53 0.223 UTERUS MICRO: DILATATION, LUMEN 2HEART 0.92 0.387 VAGINA MICRO: ESTROUS CYCLE: PROESTRUS POVARIES/OVIDUCTS 0.1066 0.045 NO SIGNIFICANTADRENAL GLANDS 0.0793 0.033 CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMURTHYROIDS/PARATHY 0.0150 0.006 JOINT BRAIN CECUM COLONFINAL BODY WT(G) 238. DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY MICRO:ADRENAL CORTEX ADRENAL MEDULLA AORTA STERNEBRAE MARROW, STERN FEMUR MARROW, FEMUR JOINT CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH, GLAN STOMACH, NON SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS PARATHYROIDS THYMUS TRACHEA URINARY BLADDER CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A11 (PAHSE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 65 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3758 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- NASAL LEVEL I NASAL LEVEL II NASAL LEVEL III NASAL LEVEL IV NASAL LEVEL V NASAL LEVEL VI GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT ^==> INDICATES MICRO CONFIRMATION OF ABOVE GROSS FINDING PGRHv4.63 06/05/2009

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 TABLE A12 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G] WEEK 3 MALE GROUP: 0 PPM----------------------------------------------------------------------------------------------------------------------------------- EPIDID ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3789 351. 2.00 9.96 3.03 1.43 0.51 1.20 1.10 3.25 0.0565 0.0222 3790 360. 2.00 10.57 2.45 1.32 0.73 1.19 1.07 3.10 0.0608 0.0211 3791 348. 1.90 9.82 2.04 1.18 0.48 1.24 1.06 3.11 0.0714 0.0177 3802 415. 2.21 12.50 2.80 1.48 0.77 1.57 1.10 3.44 0.0580 0.0240 3811 347. 1.95 9.45 2.47 1.34 0.61 1.02 1.07 3.18 0.0427 0.0194MEAN 364. 2.01 10.46 2.56 1.35 0.62 1.24 1.08 3.22 0.0579 0.0209S.D. 28.9 0.118 1.210 0.377 0.115 0.129 0.201 0.019 0.139 0.01029 0.00244S.E. 12.9 0.053 0.541 0.169 0.052 0.058 0.090 0.008 0.062 0.00460 0.00109 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A12 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G] WEEK 3 MALE GROUP: 1000 PPM----------------------------------------------------------------------------------------------------------------------------------- EPIDID ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3764 389. 1.86 11.10 2.77 1.33 0.64 1.37 1.20 3.36 0.0548 0.0150 3801 381. 1.83 10.84 2.37 1.40 0.61 1.10 1.02 3.23 0.0597 0.0152 3806 406. 2.08 13.34 2.44 1.36 0.64 1.58 1.07 3.50 0.0603 0.0177 3824 399. 1.96 11.68 2.49 1.32 0.68 1.41 1.07 3.59 0.0607 0.0230 3840 397. 2.09 12.75 2.73 1.47 0.77 1.34 0.96 3.04 0.0582 0.0257MEAN 394. 1.96 11.94 2.56 1.38 0.67 1.36 1.06 3.34 0.0587 0.0193S.D. 9.6 0.121 1.072 0.179 0.061 0.062 0.172 0.088 0.218 0.00240 0.00481S.E. 4.3 0.054 0.480 0.080 0.027 0.028 0.077 0.040 0.098 0.00107 0.00215 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A12 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G] WEEK 3 MALE GROUP: 1500 PPM----------------------------------------------------------------------------------------------------------------------------------- EPIDID ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3765 365. 1.92 9.85 2.39 1.35 0.79 1.53 1.14 3.32 0.0806 0.0180 3766 397. 2.06 11.63 2.46 1.43 0.69 1.47 1.12 3.14 0.0515 0.0183 3777 358. 2.09 10.71 2.22 1.29 0.55 1.26 0.97 2.84 0.0689 0.0180 3778 405. 2.01 13.17 2.79 1.55 0.84 1.45 1.26 3.57 0.0787 0.0211 3798 289. 1.89 8.89 2.13 1.16 0.51 1.00 1.04 2.95 0.0378 0.0182MEAN 363. 1.99 10.85 2.40 1.36 0.68 1.34 1.11 3.16 0.0635 0.0187S.D. 45.9 0.087 1.647 0.255 0.147 0.144 0.216 0.109 0.292 0.01842 0.00134S.E. 20.5 0.039 0.737 0.114 0.066 0.065 0.097 0.049 0.130 0.00824 0.00060 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A12 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G] WEEK 3 MALE GROUP: 2000 PPM----------------------------------------------------------------------------------------------------------------------------------- EPIDID ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3792 468. 2.20 15.55 3.17 1.51 0.82 1.72 1.26 3.86 0.0584 0.0255 3799 346. 1.96 10.20 2.30 1.28 0.54 1.11 1.12 3.50 0.0537 0.0208 3809 326. 1.84 10.28 2.13 1.36 0.56 0.99 1.05 3.09 0.0629 0.0147 3812 380. 2.08 10.65 2.52 1.37 0.58 1.20 1.11 3.44 0.0515 0.0197 3815 305. 1.97 8.20 2.36 1.10 0.63 1.03 0.98 3.06 0.0455 0.0153MEAN 365. 2.01 10.98 2.50 1.32 0.63 1.21 1.10 3.39 0.0544 0.0192S.D. 63.9 0.136 2.730 0.402 0.150 0.113 0.296 0.104 0.330 0.00664 0.00441S.E. 28.6 0.061 1.221 0.180 0.067 0.051 0.132 0.046 0.147 0.00297 0.00197 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A12 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G] WEEK 3 MALE GROUP: 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- EPIDID ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3783 368. 2.01 10.63 2.33 1.30 0.51 1.18 0.99 3.03 0.0618 0.0184 3785 389. 2.09 10.92 2.62 1.30 0.65 1.35 1.09 3.05 0.0569 0.0191 3807 359. 2.07 9.87 2.59 1.27 0.72 1.04 1.07 3.16 0.0712 0.0184 3810 341. 2.02 10.19 2.42 1.48 0.64 1.26 1.13 3.52 0.0562 0.0213 3831 316. 2.02 7.74 2.26 1.20 0.60 1.00 0.95 3.04 0.0696 0.0153MEAN 355. 2.04 9.87 2.44 1.31 0.62 1.17 1.05 3.16 0.0631 0.0185S.D. 27.6 0.036 1.257 0.158 0.103 0.077 0.147 0.074 0.208 0.00699 0.00215S.E. 12.4 0.016 0.562 0.071 0.046 0.034 0.066 0.033 0.093 0.00313 0.00096 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A12 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G] WEEK 3 FEMALE GROUP: 0 PPM----------------------------------------------------------------------------------------------------------------------------------- OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3691 293. 1.83 8.65 1.96 1.24 0.65 1.12 0.1244 0.0761 0.0194 3693 248. 1.82 7.57 1.72 1.16 0.48 0.88 0.1595 0.0779 0.0175 3719 232. 1.94 6.64 1.91 1.10 0.48 0.84 0.1262 0.0622 0.0189 3723 235. 1.90 6.18 1.67 1.15 0.54 0.86 0.1342 0.0641 0.0153 3733 297. 2.01 8.53 2.06 1.17 0.70 1.12 0.1506 0.0866 0.0177MEAN 261. 1.90 7.51 1.86 1.16 0.57 0.96 0.1390 0.0734 0.0178S.D. 31.6 0.079 1.103 0.164 0.050 0.100 0.143 0.01545 0.01017 0.00159S.E. 14.2 0.035 0.493 0.074 0.022 0.045 0.064 0.00691 0.00455 0.00071 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A12 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G] WEEK 3 FEMALE GROUP: 1000 PPM----------------------------------------------------------------------------------------------------------------------------------- OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3672 234. 1.88 6.59 1.68 0.92 0.56 0.81 0.1434 0.0631 0.0115 3683 241. 1.91 6.24 1.68 1.03 0.48 0.87 0.1233 0.0667 0.0194 3690 214. 1.87 5.75 1.70 0.93 0.44 0.88 0.1037 0.0681 0.0158 3697 258. 1.83 7.86 1.88 1.11 0.48 0.92 0.1478 0.0606 0.0174 3706 220. 1.79 6.45 1.69 1.03 0.52 0.86 0.1025 0.0569 0.0163MEAN 233. 1.86 6.58 1.73 1.00 0.50 0.87 0.1241 0.0631 0.0161S.D. 17.5 0.047 0.784 0.086 0.079 0.046 0.040 0.02132 0.00455 0.00291S.E. 7.8 0.021 0.351 0.039 0.035 0.020 0.018 0.00953 0.00203 0.00130 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A12 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G] WEEK 3 FEMALE GROUP: 1500 PPM----------------------------------------------------------------------------------------------------------------------------------- OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3684 253. 1.88 7.77 1.61 1.17 0.54 1.30 0.1359 0.0755 0.0173 3724 262. 1.83 7.35 1.77 0.98 0.55 0.87 0.1345 0.0721 0.0150 3728 251. 2.00 7.42 1.87 1.09 0.57 1.02 0.1345 0.0680 0.0173 3729 259. 2.01 7.85 1.92 1.10 0.64 0.90 0.1381 0.0762 0.0220 3748 238. 1.96 7.43 1.83 1.17 0.53 0.88 0.1417 0.0671 0.0177MEAN 253. 1.94 7.56 1.80 1.10 0.57 0.99 0.1369 0.0718 0.0179S.D. 9.3 0.078 0.228 0.120 0.078 0.044 0.181 0.00304 0.00417 0.00255S.E. 4.2 0.035 0.102 0.053 0.035 0.020 0.081 0.00136 0.00187 0.00114 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A12 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G] WEEK 3 FEMALE GROUP: 2000 PPM----------------------------------------------------------------------------------------------------------------------------------- OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3682 247. 1.95 7.80 1.61 1.06 0.44 1.01 0.1715 0.0495 0.0127 3705 208. 1.93 5.95 1.61 1.04 0.42 0.83 0.1136 0.0643 0.0165 3710 242. 1.84 7.45 1.90 1.25 0.41 0.92 0.1434 0.0716 0.0233 3740 247. 2.01 8.04 1.68 1.05 0.53 0.88 0.1351 0.0686 0.0197 3749 253. 1.96 7.63 1.83 1.10 0.39 1.07 0.1472 0.0767 0.0140MEAN 239. 1.94 7.37 1.73 1.10 0.44 0.94 0.1422 0.0661 0.0172S.D. 18.0 0.062 0.825 0.132 0.087 0.054 0.097 0.02094 0.01034 0.00431S.E. 8.0 0.028 0.369 0.059 0.039 0.024 0.044 0.00936 0.00462 0.00193 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A12 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL ORGAN WEIGHTS AND FINAL BODY WEIGHTS [G] WEEK 3 FEMALE GROUP: 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3688 256. 1.95 7.96 1.68 1.21 0.49 0.82 0.1260 0.0782 0.0157 3703 215. 1.78 7.07 1.50 0.89 0.38 0.83 0.1000 0.0502 0.0146 3717 209. 1.81 6.67 1.67 1.05 0.33 0.77 0.1553 0.0542 0.0151 3755 246. 2.10 8.11 1.65 1.20 0.49 1.20 0.1452 0.0694 0.0138 3758 238. 1.87 7.73 1.94 1.11 0.53 0.92 0.1066 0.0793 0.0150MEAN 233. 1.90 7.51 1.69 1.09 0.44 0.91 0.1266 0.0663 0.0148S.D. 20.1 0.128 0.614 0.159 0.131 0.085 0.172 0.02386 0.01347 0.00070S.E. 9.0 0.057 0.275 0.071 0.059 0.038 0.077 0.01067 0.00602 0.00031 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT POFBWv4.14 05/11/2009

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 TABLE A13 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G] WEEK 3 MALE GROUP: 0 PPM----------------------------------------------------------------------------------------------------------------------------------- EPIDID ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3789 351. 0.570 2.838 0.863 0.407 0.145 0.342 0.313 0.926 0.016 0.006 3790 360. 0.556 2.936 0.681 0.367 0.203 0.331 0.297 0.861 0.017 0.006 3791 348. 0.546 2.822 0.586 0.339 0.138 0.356 0.305 0.894 0.021 0.005 3802 415. 0.533 3.012 0.675 0.357 0.186 0.378 0.265 0.829 0.014 0.006 3811 347. 0.562 2.723 0.712 0.386 0.176 0.294 0.308 0.916 0.012 0.006MEAN 364. 0.553 2.866 0.703 0.371 0.170 0.340 0.298 0.885 0.016 0.006S.D. 28.9 0.0144 0.1111 0.1008 0.0263 0.0275 0.0312 0.0191 0.0401 0.0034 0.0004S.E. 12.9 0.0064 0.0497 0.0451 0.0117 0.0123 0.0140 0.0086 0.0179 0.0015 0.0002 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

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 TABLE A13 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G] WEEK 3 MALE GROUP: 1000 PPM----------------------------------------------------------------------------------------------------------------------------------- EPIDID ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3764 389. 0.478 2.853 0.712 0.342 0.165 0.352 0.308 0.864 0.014 0.004 3801 381. 0.480 2.845 0.622 0.367 0.160 0.289 0.268 0.848 0.016 0.004 3806 406. 0.512 3.286 0.601 0.335 0.158 0.389 0.264 0.862 0.015 0.004 3824 399. 0.491 2.927 0.624 0.331 0.170 0.353 0.268 0.900 0.015 0.006 3840 397. 0.526 3.212 0.688 0.370 0.194 0.338 0.242 0.766 0.015 0.006MEAN 394. 0.497 3.025 0.649 0.349 0.169 0.344 0.270 0.848 0.015 0.005S.D. 9.6 0.0209 0.2090 0.0478 0.0183 0.0145 0.0362 0.0238 0.0497 0.0007 0.0011S.E. 4.3 0.0094 0.0935 0.0214 0.0082 0.0065 0.0162 0.0107 0.0222 0.0003 0.0005 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A13 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G] WEEK 3 MALE GROUP: 1500 PPM----------------------------------------------------------------------------------------------------------------------------------- EPIDID ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3765 365. 0.526 2.699 0.655 0.370 0.216 0.419 0.312 0.910 0.022 0.005 3766 397. 0.519 2.929 0.620 0.360 0.174 0.370 0.282 0.791 0.013 0.005 3777 358. 0.584 2.992 0.620 0.360 0.154 0.352 0.271 0.793 0.019 0.005 3778 405. 0.496 3.252 0.689 0.383 0.207 0.358 0.311 0.881 0.019 0.005 3798 289. 0.654 3.076 0.737 0.401 0.176 0.346 0.360 1.021 0.013 0.006MEAN 363. 0.556 2.990 0.664 0.375 0.185 0.369 0.307 0.879 0.017 0.005S.D. 45.9 0.0638 0.2028 0.0498 0.0174 0.0255 0.0293 0.0345 0.0952 0.0040 0.0004S.E. 20.5 0.0285 0.0907 0.0223 0.0078 0.0114 0.0131 0.0154 0.0426 0.0018 0.0002 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A13 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G] WEEK 3 MALE GROUP: 2000 PPM----------------------------------------------------------------------------------------------------------------------------------- EPIDID ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3792 468. 0.470 3.323 0.677 0.323 0.175 0.368 0.269 0.825 0.012 0.005 3799 346. 0.566 2.948 0.665 0.370 0.156 0.321 0.324 1.012 0.016 0.006 3809 326. 0.564 3.153 0.653 0.417 0.172 0.304 0.322 0.948 0.019 0.005 3812 380. 0.547 2.803 0.663 0.361 0.153 0.316 0.292 0.905 0.014 0.005 3815 305. 0.646 2.689 0.774 0.361 0.207 0.338 0.321 1.003 0.015 0.005MEAN 365. 0.559 2.983 0.686 0.366 0.173 0.329 0.306 0.939 0.015 0.005S.D. 63.9 0.0627 0.2572 0.0497 0.0336 0.0215 0.0248 0.0243 0.0769 0.0026 0.0004S.E. 28.6 0.0280 0.1150 0.0222 0.0150 0.0096 0.0111 0.0109 0.0344 0.0012 0.0002 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A13 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G] WEEK 3 MALE GROUP: 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- EPIDID ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3783 368. 0.546 2.889 0.633 0.353 0.139 0.321 0.269 0.823 0.017 0.005 3785 389. 0.537 2.807 0.674 0.334 0.167 0.347 0.280 0.784 0.015 0.005 3807 359. 0.577 2.749 0.721 0.354 0.201 0.290 0.298 0.880 0.020 0.005 3810 341. 0.592 2.988 0.710 0.434 0.188 0.370 0.331 1.032 0.016 0.006 3831 316. 0.639 2.449 0.715 0.380 0.190 0.316 0.301 0.962 0.022 0.005MEAN 355. 0.578 2.776 0.691 0.371 0.177 0.329 0.296 0.896 0.018 0.005S.D. 27.6 0.0407 0.2039 0.0370 0.0388 0.0245 0.0307 0.0237 0.1012 0.0029 0.0004S.E. 12.4 0.0182 0.0912 0.0166 0.0174 0.0110 0.0137 0.0106 0.0453 0.0013 0.0002 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A13 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G] WEEK 3 FEMALE GROUP: 0 PPM----------------------------------------------------------------------------------------------------------------------------------- OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3691 293. 0.625 2.952 0.669 0.423 0.222 0.382 0.042 0.026 0.007 3693 248. 0.734 3.052 0.694 0.468 0.194 0.355 0.064 0.031 0.007 3719 232. 0.836 2.862 0.823 0.474 0.207 0.362 0.054 0.027 0.008 3723 235. 0.809 2.630 0.711 0.489 0.230 0.366 0.057 0.027 0.007 3733 297. 0.677 2.872 0.694 0.394 0.236 0.377 0.051 0.029 0.006MEAN 261. 0.736 2.874 0.718 0.450 0.218 0.368 0.054 0.028 0.007S.D. 31.6 0.0882 0.1561 0.0605 0.0396 0.0172 0.0110 0.0081 0.0020 0.0007S.E. 14.2 0.0395 0.0698 0.0270 0.0177 0.0077 0.0049 0.0036 0.0009 0.0003 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A13 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G] WEEK 3 FEMALE GROUP: 1000 PPM----------------------------------------------------------------------------------------------------------------------------------- OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3672 234. 0.803 2.816 0.718 0.393 0.239 0.346 0.061 0.027 0.005 3683 241. 0.793 2.589 0.697 0.427 0.199 0.361 0.051 0.028 0.008 3690 214. 0.874 2.687 0.794 0.435 0.206 0.411 0.048 0.032 0.007 3697 258. 0.709 3.047 0.729 0.430 0.186 0.357 0.057 0.023 0.007 3706 220. 0.814 2.932 0.768 0.468 0.236 0.391 0.047 0.026 0.007MEAN 233. 0.799 2.814 0.741 0.431 0.213 0.373 0.053 0.027 0.007S.D. 17.5 0.0592 0.1837 0.0392 0.0267 0.0233 0.0269 0.0060 0.0033 0.0011S.E. 7.8 0.0265 0.0821 0.0175 0.0119 0.0104 0.0120 0.0027 0.0015 0.0005 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A13 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G] WEEK 3 FEMALE GROUP: 1500 PPM----------------------------------------------------------------------------------------------------------------------------------- OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3684 253. 0.743 3.071 0.636 0.462 0.213 0.514 0.054 0.030 0.007 3724 262. 0.698 2.805 0.676 0.374 0.210 0.332 0.051 0.028 0.006 3728 251. 0.797 2.956 0.745 0.434 0.227 0.406 0.054 0.027 0.007 3729 259. 0.776 3.031 0.741 0.425 0.247 0.347 0.053 0.029 0.008 3748 238. 0.824 3.122 0.769 0.492 0.223 0.370 0.060 0.028 0.007MEAN 253. 0.768 2.997 0.713 0.437 0.224 0.394 0.054 0.028 0.007S.D. 9.3 0.0489 0.1233 0.0553 0.0441 0.0146 0.0728 0.0034 0.0011 0.0007S.E. 4.2 0.0219 0.0551 0.0247 0.0197 0.0065 0.0325 0.0015 0.0005 0.0003 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A13 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G] WEEK 3 FEMALE GROUP: 2000 PPM----------------------------------------------------------------------------------------------------------------------------------- OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3682 247. 0.789 3.158 0.652 0.429 0.178 0.409 0.069 0.020 0.005 3705 208. 0.928 2.861 0.774 0.500 0.202 0.399 0.055 0.031 0.008 3710 242. 0.760 3.079 0.785 0.517 0.169 0.380 0.059 0.030 0.010 3740 247. 0.814 3.255 0.680 0.425 0.215 0.356 0.055 0.028 0.008 3749 253. 0.775 3.016 0.723 0.435 0.154 0.423 0.058 0.030 0.006MEAN 239. 0.813 3.074 0.723 0.461 0.184 0.393 0.059 0.028 0.007S.D. 18.0 0.0672 0.1488 0.0577 0.0437 0.0247 0.0261 0.0058 0.0045 0.0019S.E. 8.0 0.0300 0.0665 0.0258 0.0196 0.0111 0.0117 0.0026 0.0020 0.0009 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A13 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL ORGAN WTS. RELATIVE TO FINAL BODY WTS. [G/100 G] WEEK 3 FEMALE GROUP: 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) BRAIN LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3688 256. 0.762 3.109 0.656 0.473 0.191 0.320 0.049 0.031 0.006 3703 215. 0.828 3.288 0.698 0.414 0.177 0.386 0.047 0.023 0.007 3717 209. 0.866 3.191 0.799 0.502 0.158 0.368 0.074 0.026 0.007 3755 246. 0.854 3.297 0.671 0.488 0.199 0.488 0.059 0.028 0.006 3758 238. 0.786 3.248 0.815 0.466 0.223 0.387 0.045 0.033 0.006MEAN 233. 0.819 3.227 0.728 0.469 0.190 0.390 0.055 0.028 0.006S.D. 20.1 0.0443 0.0779 0.0741 0.0335 0.0243 0.0613 0.0120 0.0040 0.0005S.E. 9.0 0.0198 0.0348 0.0331 0.0150 0.0109 0.0274 0.0054 0.0018 0.0002 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT POFBWv4.14 05/11/2009

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A14 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G] WEEK 3 MALE GROUP: 0 PPM----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT EPIDID ADRENAL THYROIDS ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3789 351. 2.00 498.000 151.500 71.500 25.500 60.000 55.000 162.500 2.825 1.110 3790 360. 2.00 528.500 122.500 66.000 36.500 59.500 53.500 155.000 3.040 1.055 3791 348. 1.90 516.842 107.368 62.105 25.263 65.263 55.789 163.684 3.758 0.932 3802 415. 2.21 565.611 126.697 66.968 34.842 71.041 49.774 155.656 2.624 1.086 3811 347. 1.95 484.615 126.667 68.718 31.282 52.308 54.872 163.077 2.190 0.995MEAN 364. 2.01 518.714 126.946 67.058 30.677 61.622 53.787 159.983 2.887 1.036S.D. 28.9 0.118 31.1866 15.8596 3.4694 5.1897 6.9975 2.3897 4.2767 0.5790 0.0722S.E. 12.9 0.053 13.9471 7.0926 1.5516 2.3209 3.1294 1.0687 1.9126 0.2589 0.0323 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A14 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G] WEEK 3 MALE GROUP: 1000 PPM----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT EPIDID ADRENAL THYROIDS ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3764 389. 1.86 596.774 148.925 71.505 34.409 73.656 64.516 180.645 2.946 0.806 3801 381. 1.83 592.350 129.508 76.503 33.333 60.109 55.738 176.503 3.262 0.831 3806 406. 2.08 641.346 117.308 65.385 30.769 75.962 51.442 168.269 2.899 0.851 3824 399. 1.96 595.918 127.041 67.347 34.694 71.939 54.592 183.163 3.097 1.173 3840 397. 2.09 610.048 130.622 70.335 36.842 64.115 45.933 145.455 2.785 1.230MEAN 394. 1.96 607.287 130.681 70.215 34.009 69.156 54.444 170.807 2.998 0.978S.D. 9.6 0.121 20.1899 11.4707 4.2653 2.2141 6.7375 6.7932 15.2567 0.1853 0.2055S.E. 4.3 0.054 9.0292 5.1299 1.9075 0.9902 3.0131 3.0380 6.8230 0.0829 0.0919 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A14 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G] WEEK 3 MALE GROUP: 1500 PPM----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT EPIDID ADRENAL THYROIDS ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3765 365. 1.92 513.021 124.479 70.313 41.146 79.688 59.375 172.917 4.198 0.938 3766 397. 2.06 564.563 119.417 69.417 33.495 71.359 54.369 152.427 2.500 0.888 3777 358. 2.09 512.440 106.220 61.722 26.316 60.287 46.411 135.885 3.297 0.861 3778 405. 2.01 655.224 138.806 77.114 41.791 72.139 62.687 177.612 3.915 1.050 3798 289. 1.89 470.370 112.698 61.376 26.984 52.910 55.026 156.085 2.000 0.963MEAN 363. 1.99 543.124 120.324 67.988 33.946 67.277 55.574 158.985 3.182 0.940S.D. 45.9 0.087 71.0051 12.4172 6.5900 7.4208 10.6019 6.1391 16.7786 0.9280 0.0734S.E. 20.5 0.039 31.7544 5.5532 2.9471 3.3187 4.7413 2.7455 7.5036 0.4150 0.0328 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A14 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G] WEEK 3 MALE GROUP: 2000 PPM----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT EPIDID ADRENAL THYROIDS ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3792 468. 2.20 706.818 144.091 68.636 37.273 78.182 57.273 175.455 2.655 1.159 3799 346. 1.96 520.408 117.347 65.306 27.551 56.633 57.143 178.571 2.740 1.061 3809 326. 1.84 558.696 115.761 73.913 30.435 53.804 57.065 167.935 3.418 0.799 3812 380. 2.08 512.019 121.154 65.865 27.885 57.692 53.365 165.385 2.476 0.947 3815 305. 1.97 416.244 119.797 55.838 31.980 52.284 49.746 155.330 2.310 0.777MEAN 365. 2.01 542.837 123.630 65.912 31.025 59.719 54.918 168.535 2.720 0.949S.D. 63.9 0.136 105.6171 11.6283 6.5820 3.9442 10.5449 3.3267 9.1278 0.4241 0.1649S.E. 28.6 0.061 47.2334 5.2003 2.9436 1.7639 4.7158 1.4877 4.0821 0.1897 0.0737 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A14 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G] WEEK 3 MALE GROUP: 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT EPIDID ADRENAL THYROIDS ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS LUNGS SPLEEN HEART YMIDES TESTES GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3783 368. 2.01 528.856 115.920 64.677 25.373 58.706 49.254 150.746 3.075 0.915 3785 389. 2.09 522.488 125.359 62.201 31.100 64.593 52.153 145.933 2.722 0.914 3807 359. 2.07 476.812 125.121 61.353 34.783 50.242 51.691 152.657 3.440 0.889 3810 341. 2.02 504.455 119.802 73.267 31.683 62.376 55.941 174.257 2.782 1.054 3831 316. 2.02 383.168 111.881 59.406 29.703 49.505 47.030 150.495 3.446 0.757MEAN 355. 2.04 483.156 119.617 64.181 30.528 57.084 51.214 154.818 3.093 0.906S.D. 27.6 0.036 59.4285 5.8483 5.4203 3.4286 6.9151 3.3467 11.1440 0.3463 0.1055S.E. 12.4 0.016 26.5772 2.6155 2.4240 1.5333 3.0925 1.4967 4.9838 0.1549 0.0472 N 5 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A14 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G] WEEK 3 FEMALE GROUP: 0 PPM----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3691 293. 1.83 472.678 107.104 67.760 35.519 61.202 6.798 4.158 1.060 3693 248. 1.82 415.934 94.505 63.736 26.374 48.352 8.764 4.280 0.962 3719 232. 1.94 342.268 98.454 56.701 24.742 43.299 6.505 3.206 0.974 3723 235. 1.90 325.263 87.895 60.526 28.421 45.263 7.063 3.374 0.805 3733 297. 2.01 424.378 102.488 58.209 34.826 55.721 7.493 4.308 0.881MEAN 261. 1.90 396.104 98.089 61.386 29.976 50.767 7.325 3.865 0.936S.D. 31.6 0.079 61.1821 7.3742 4.4422 4.9253 7.5055 0.8829 0.5314 0.0971S.E. 14.2 0.035 27.3614 3.2979 1.9866 2.2027 3.3566 0.3948 0.2377 0.0434 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A14 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G] WEEK 3 FEMALE GROUP: 1000 PPM----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3672 234. 1.88 350.532 89.362 48.936 29.787 43.085 7.628 3.356 0.612 3683 241. 1.91 326.702 87.958 53.927 25.131 45.550 6.455 3.492 1.016 3690 214. 1.87 307.487 90.909 49.733 23.529 47.059 5.545 3.642 0.845 3697 258. 1.83 429.508 102.732 60.656 26.230 50.273 8.077 3.311 0.951 3706 220. 1.79 360.335 94.413 57.542 29.050 48.045 5.726 3.179 0.911MEAN 233. 1.86 354.913 93.075 54.159 26.745 46.802 6.686 3.396 0.867S.D. 17.5 0.047 46.5245 5.9099 5.0144 2.6353 2.6946 1.1291 0.1772 0.1555S.E. 7.8 0.021 20.8064 2.6430 2.2425 1.1786 1.2050 0.5049 0.0793 0.0695 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A14 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G] WEEK 3 FEMALE GROUP: 1500 PPM----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3684 253. 1.88 413.298 85.638 62.234 28.723 69.149 7.229 4.016 0.920 3724 262. 1.83 401.639 96.721 53.552 30.055 47.541 7.350 3.940 0.820 3728 251. 2.00 371.000 93.500 54.500 28.500 51.000 6.725 3.400 0.865 3729 259. 2.01 390.547 95.522 54.726 31.841 44.776 6.871 3.791 1.095 3748 238. 1.96 379.082 93.367 59.694 27.041 44.898 7.230 3.423 0.903MEAN 253. 1.94 391.113 92.950 56.941 29.232 51.473 7.081 3.714 0.921S.D. 9.3 0.078 16.9746 4.3237 3.8061 1.8083 10.2006 0.2680 0.2879 0.1048S.E. 4.2 0.035 7.5913 1.9336 1.7021 0.8087 4.5618 0.1199 0.1287 0.0469 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A14 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G] WEEK 3 FEMALE GROUP: 2000 PPM----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3682 247. 1.95 400.000 82.564 54.359 22.564 51.795 8.795 2.538 0.651 3705 208. 1.93 308.290 83.420 53.886 21.762 43.005 5.886 3.332 0.855 3710 242. 1.84 404.891 103.261 67.935 22.283 50.000 7.793 3.891 1.266 3740 247. 2.01 400.000 83.582 52.239 26.368 43.781 6.721 3.413 0.980 3749 253. 1.96 389.286 93.367 56.122 19.898 54.592 7.510 3.913 0.714MEAN 239. 1.94 380.493 89.239 56.908 22.575 48.635 7.341 3.417 0.893S.D. 18.0 0.062 40.7642 9.0010 6.3175 2.3611 5.0644 1.1010 0.5591 0.2443S.E. 8.0 0.028 18.2303 4.0254 2.8253 1.0559 2.2649 0.4924 0.2501 0.1093 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A14 (PHASE I)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL ORGAN WEIGHTS RELATIVE TO BRAIN WEIGHTS [G/100 G] WEEK 3 FEMALE GROUP: 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- BRAIN WT OVARIES/ ADRENAL THYROIDS ANIMAL FBW(G) (GRAMS) LIVER KIDNEYS LUNGS SPLEEN HEART OVIDUCTS GLANDS /PARATHY----------------------------------------------------------------------------------------------------------------------------------- 3688 256. 1.95 408.205 86.154 62.051 25.128 42.051 6.462 4.010 0.805 3703 215. 1.78 397.191 84.270 50.000 21.348 46.629 5.618 2.820 0.820 3717 209. 1.81 368.508 92.265 58.011 18.232 42.541 8.580 2.994 0.834 3755 246. 2.10 386.191 78.571 57.143 23.333 57.143 6.914 3.305 0.657 3758 238. 1.87 413.369 103.743 59.358 28.342 49.198 5.701 4.241 0.802MEAN 233. 1.90 394.693 89.001 57.313 23.277 47.512 6.655 3.474 0.784S.D. 20.1 0.128 17.9969 9.5819 4.4896 3.8163 6.1423 1.2037 0.6250 0.0719S.E. 9.0 0.057 8.0485 4.2852 2.0078 1.7067 2.7469 0.5383 0.2795 0.0322 N 5 5 5 5 5 5 5 5 5 5FBW = FINAL BODY WEIGHT POFBWv4.14 05/11/2009

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A15 (HOME CAGE OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3774 2 1 1 1 1 4 13776 4 1 1 1 1 1 13780 2 1 1 1 1 4 13787 3 1 1 1 1 1 43803 2 1 1 1 1 3 43826 2 1 1 1 1 4 13828 2 1 1 1 1 4 43832 4 1 1 1 1 2 43837 4 1 1 1 1 2 13843 2 1 1 1 1 1 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A15 (HOME CAGE OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3769 3 1 1 1 1 1 13772 2 1 1 1 1 4 13773 2 1 1 1 1 4 13781 1 1 1 1 1 1 13800 1 1 1 1 1 1 43805 4 1 1 1 1 2 13816 1 1 1 1 1 1 13818 2 1 1 1 1 4 43845 2 1 1 1 1 4 43846 1 1 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A15 (HOME CAGE OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3762 2 1 1 1 1 4 43768 2 1 1 1 1 4 13786 3 1 1 1 1 1 43788 2 1 1 1 1 4 43813 4 1 1 1 1 2 43819 4 1 1 1 1 1 43825 3 1 1 1 1 1 43833 2 1 1 1 1 4 13841 2 1 1 1 1 4 13842 1 1 1 1 1 1 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A15 (HOME CAGE OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3760 4 1 1 1 1 1 13770 2 1 1 1 1 4 13779 4 1 1 1 1 1 43782 4 1 1 1 1 1 43784 2 1 1 1 1 4 43793 2 1 1 1 1 3 13794 1 1 1 1 1 1 13820 2 1 1 1 1 4 43821 2 1 1 1 1 4 43838 4 1 1 1 1 3 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A15 (HOME CAGE OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3763 2 1 1 1 1 3 43767 2 1 1 1 1 4 13771 4 1 1 1 1 2 13775 2 1 1 1 1 4 13795 1 1 1 1 1 1 43804 2 1 1 1 1 4 43814 1 1 1 1 1 1 13817 2 1 1 1 1 4 13822 2 1 1 1 1 4 13839 1 1 1 1 1 1 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A15 (HOME CAGE OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3677 1 1 1 1 1 1 43686 3,8 1 1 1 1 1 13694 3 1 1 1 1 1 13696 2 1 1 1 1 4 13704 3 1 1 1 1 1 43714 1 1 1 1 1 1 13725 4 1 1 1 1 2 43738 2 1 1 1 1 3 43744 1 1 1 1 1 1 13757 1 1 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A15 (HOME CAGE OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3675 3,8 1 1 1 1 1 13695 2 1 1 1 1 3 43700 2 1 1 1 1 4 43702 1 1 1 1 1 1 43712 2 1 1 1 1 4 13713 1 1 1 1 1 1 13718 2 1 1 1 1 4 43720 2 1 1 1 1 4 43743 2 1 1 1 1 4 13747 4 1 1 1 1 3 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A15 (HOME CAGE OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3674 4 1 1 1 1 1 13701 3 1 1 1 1 1 43708 2 1 1 1 1 4 43711 1 1 1 1 1 1 43722 2 1 1 1 1 4 43726 1 1 1 1 1 1 43727 2 1 1 1 1 4 13731 3 1 1 1 1 1 43734 3 1 1 1 1 1 13756 1 1 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A15 (HOME CAGE OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3676 1 1 1 1 1 1 43678 4 1 1 1 1 3 43709 4 1 1 1 1 3 13716 2 1 1 1 1 4 43732 1 1 1 1 1 1 13739 1 1 1 1 1 1 43745 2 1 1 1 1 4 43746 2 1 1 1 1 1 43751 1 1 1 1 1 1 43754 2 1 1 1 1 4 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A15 (HOME CAGE OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3673 4 1 1 1 1 2 43679 4 1 1 1 1 3 43680 1 1 1 1 1 1 43685 1 1 1 1 1 1 43689 4 1 1 1 1 1 13698 2 1 1 1 1 2 13721 1 1 1 1 1 1 43730 3 1 1 1 1 1 13742 1 1 1 1 1 1 43753 1 1 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE PFOBv3.25 05/11/2009 R:06/05/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A16 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3774 2 1 1 1 1 4 43776 1 1 1 1 1 1 13780 1 1 1 1 1 1 43787 1 1 1 1 1 1 43803 4 1 1 1 1 3 43826 4 1 1 1 1 2 43828 2 1 1 1 1 4 43832 3,8 1 1 1 1 1 43837 3 1 1 1 1 1 13843 1 1 1 1 1 1 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A16 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3769 3 1 1 1 1 1 43772 4 1 1 1 1 1 13773 3 1 1 1 1 1 43781 4 1 1 1 1 1 43800 1 1 1 1 1 1 43805 4 1 1 1 1 3 43816 2 1 1 1 1 4 43818 3,8 1 1 1 1 1 13845 2 1 1 1 1 4 43846 2 1 1 1 1 4 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A16 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3762 4 1 1 1 1 2 43768 3 1 1 1 1 1 13786 3 1 1 1 1 1 43788 3 1 1 1 1 1 43813 8 1 1 1 1 1 13819 3,8 1 1 1 1 1 43825 2 1 1 1 1 3 43833 2 1 1 1 1 4 43841 4 1 1 1 1 2 13842 2 1 1 1 1 3 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A16 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3760 4 1 1 1 1 2 43779 1 1 1 1 1 1 13782 1 1 1 1 1 1 43784 2 1 1 1 1 4 13793 3,8 1 1 1 1 1 13794 3,8 1 1 1 1 1 43820 1 1 1 1 1 1 43821 2 1 1 1 1 4 43838 1 1 1 1 1 1 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A16 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3763 1 1 1 1 1 1 13767 2 1 1 1 1 4 43771 1 1 1 1 1 1 13775 1 1 1 1 1 1 43795 1 1 1 1 1 1 43804 3,8 1 1 1 1 1 43814 4 1 1 1 1 2 43817 3,8 1 1 1 1 1 43822 2 1 1 1 1 4 13839 1 1 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A16 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3677 1 1 1 1 1 1 43686 3,8 1 1 1 1 1 43694 3,8 1 1 1 1 1 43696 3 1 1 1 1 1 43704 1 1 1 1 1 1 43714 3,8 1 1 1 2 1 43725 3,8 1 1 1 1 1 43738 4 1 1 1 1 1 13744 1 1 1 1 1 1 43757 1 1 1 1 1 1 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A16 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3675 2 1 1 1 1 4 43695 4 1 1 1 1 1 43700 1 1 1 1 1 1 43702 8 1 1 1 1 1 13712 3,8 1 1 1 1 1 43713 1 1 1 1 1 1 43718 3,8 1 1 1 1 1 13720 3,8 1 1 1 1 1 13743 3,8 1 1 1 1 1 43747 1 1 1 1 1 1 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A16 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3674 8 1 1 1 1 1 13701 3,8 1 1 1 1 1 43708 3,8 1 1 1 1 1 13711 3,8 1 1 1 1 1 43722 2 1 1 1 1 4 43726 3 1 1 1 1 1 43727 1 1 1 1 1 1 43731 3,8 1 1 1 1 1 43734 1 1 1 1 1 1 43756 1 1 1 1 1 1 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A16 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3676 3 1 1 1 1 1 43678 3,8 1 1 1 1 1 43709 3,8 1 1 1 1 1 43716 2 1 1 1 1 4 43732 8 1 1 1 1 1 43739 3 1 1 1 1 1 43745 1 1 1 1 1 1 43746 3,8 1 1 1 1 1 13751 3,8 1 1 1 1 1 43754 4 1 1 1 1 3 4-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A16 (HOME CAGE OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHOME CAGE OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CONVULSIONSANIMAL ----------------- PALPEBRAL FECESNUMBER POSTURE CLONIC TONIC TREMORS BITING CLOSURE CONSISTENCY-----------------------------------------------------------------------------------------------------------------------------------3673 1 1 1 1 1 1 43679 1 1 1 1 1 1 13680 3 1 1 1 1 1 43685 3,8 1 1 1 1 1 43689 4 1 1 1 1 2 13698 1 1 1 1 1 1 13721 1 1 1 1 1 1 43730 3,8 1 1 1 1 1 43742 3 1 1 1 1 1 43753 2 1 1 1 1 3 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE PFOBv3.25 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3774 1 1 1 1 13776 1 1 1 1 13780 1 1 1 1 13787 1 1 1 1 13803 1 1 1 1 13826 1 1 1 1 13828 1 1 1 1 13832 1 1 1 1 13837 1 1 1 1 13843 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3774 1 1 1 1 1 2 2 23776 1 1 1 1 1 2 2 23780 1 1 1 1 1 2 2 23787 1 1 1 1 1 2 2 23803 1 1 1 1 1 2 2 23826 1 1 1 1 1 2 2 23828 1 1 1 1 1 2 2 23832 1 1 1 1 1 2 2 23837 1 1 1 1 1 2 2 23843 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3774 2 2 2 1 1 1 1 13776 2 2 2 1 1 1 1 13780 2 2 2 1 1 1 1 13787 2 2 2 1 1 1 1 13803 2 2 2 1 1 1 1 13826 2 2 2 1 1 1 1 13828 2 2 2 1 1 1 1 13832 2 2 2 1 1 1 1 13837 2 2 2 1 1 1 1 13843 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3769 2* 1 1 1 13772 1 1 1 1 13773 1 1 1 1 13781 1 1 1 1 13800 2* 2* 1 1 13805 1 1 1 1 13816 1 2 1 1 13818 1 1 1 1 13845 1 2 1 1 13846 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3769 1 1 1 1 1 2 2 23772 1 1 1 1 1 2 2 23773 1 1 1 1 1 2 2 23781 1 1 1 1 1 2 2 23800 1 1 1 1 1 2 2 23805 1 1 1 1 1 2 2 23816 1 1 1 1 1 2 2 23818 1 1 1 1 1 2 2 23845 1 1 1 1 1 2 2 23846 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3769 2 2 2 1 1 1 1 13772 2 2 2 1 1 1 1 13773 2 2 2 1 1 1 1 13781 2 2 2 1 1 1 1 13800 2 2 2 1 1 1 1 13805 2 2 2 1 1 1 1 13816 2 2 2 1 1 1 1 13818 2 2 2 1 1 1 1 13845 2 2 2 1 1 1 1 13846 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3762 1 1 1 1 13768 1 1 1 1 13786 1 1 1 1 13788 1 1 1 1 13813 1 1 1 1 13819 1 1 1 1 13825 1 1 1 1 13833 1 1 1 1 13841 1 1 1 1 13842 2 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3762 1 1 1 1 1 2 2 23768 1 1 1 1 1 2 2 23786 1 1 1 1 1 2 2 23788 1 1 1 1 1 2 2 23813 1 1 1 1 1 2 2 23819 1 1 1 1 1 2 2 23825 1 1 1 1 1 2 2 23833 1 1 1 1 1 2 2 23841 1 1 1 1 1 2 2 23842 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3762 2 2 2 1 1 1 1 13768 2 2 2 1 1 1 1 13786 2 2 2 1 1 1 1 13788 2 2 2 1 1 1 1 13813 2 2 2 1 1 1 1 13819 2 2 2 1 1 1 1 13825 2 2 2 1 1 1 1 13833 2 2 2 1 1 1 1 13841 2 2 2 1 1 1 1 13842 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3760 1 1 1 1 13770 1 1 1 1 13779 1 1 1 1 13782 1 1 1 1 13784 2 2 1 1 13793 1 1 1 1 13794 1 1 1 1 13820 1 2 1 1 13821 1 1 1 1 13838 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3760 1 1 1 1 1 2 2 23770 1 1 1 1 1 2 2 23779 1 1 1 1 1 2 2 23782 1 1 1 1 1 2 2 23784 1 1 1 1 1 2 2 23793 1 1 1 1 1 2 2 23794 1 1 1 1 1 2 2 23820 1 1 1 1 1 2 2 23821 1 1 1 1 1 2 2 23838 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3760 2 2 2 1 1 1 1 13770 2 2 2 1 1 1 1 13779 2 2 2 1 1 1 1 13782 2 2 2 1 1 1 1 13784 2 2 2 1 1 1 1 13793 2 2 2 1 1 1 1 13794 2 2 2 1 1 1 1 13820 2 2 2 1 1 1 1 13821 2 2 2 1 1 1 1 13838 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3763 1 1 1 1 13767 1 1 1 1 13771 2* 1 1 1 13775 1 1 1 1 13795 1 1 1 1 13804 1 1 1 1 13814 1 1 1 1 13817 1 1 1 1 13822 1 1 1 1 13839 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3763 1 1 1 1 1 2 2 23767 1 1 1 1 1 2 2 23771 1 1 1 1 1 2 2 23775 1 1 1 1 1 2 2 23795 1 1 1 1 1 2 2 23804 1 1 1 1 1 2 2 23814 1 1 1 1 1 2 2 23817 1 1 1 1 1 2 2 23822 1 1 1 1 1 2 2 23839 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3763 2 2 2 1 1 1 1 13767 2 2 2 1 1 1 1 13771 2 2 2 1 1 1 1 13775 2 2 2 1 1 1 1 13795 2 2 2 1 1 1 1 13804 2 2 2 1 1 1 1 13814 2 2 2 1 1 1 1 13817 2 2 2 1 1 1 1 13822 2 2 2 1 1 1 1 13839 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3677 1 1 1 1 13686 2 1 1 1 13694 1 1 1 1 13696 1 1 1 1 13704 1 1 1 1 13714 1 1 1 1 13725 1 1 1 1 13738 2* 1 1 1 13744 1 1 1 1 13757 2 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3677 1 1 1 1 1 2 2 23686 1 1 1 1 1 2 2 23694 1 1 1 1 1 2 2 23696 1 1 1 1 1 2 2 23704 1 1 1 1 1 2 2 23714 1 1 1 1 1 2 2 23725 1 1 1 1 1 2 2 23738 1 1 1 1 1 2 2 23744 1 1 1 1 1 2 2 23757 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3677 2 2 2 1 1 1 1 13686 2 2 2 1 1 1 1 13694 2 2 2 1 1 1 1 13696 2 2 2 1 1 1 1 13704 2 2 2 1 1 1 1 13714 2 2 2 1 1 1 1 13725 2 2 2 1 1 1 1 13738 2 2 2 1 1 1 1 13744 2 2 2 1 1 1 1 13757 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3675 1 1 1 1 13695 1 1 1 1 13700 2* 1 1 1 13702 1 1 1 1 13712 1 1 1 1 13713 1 1 1 1 13718 1 1 1 1 13720 2* 1 1 1 13743 1 1 1 1 13747 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3675 1 1 1 1 1 2 2 23695 1 1 1 1 1 2 2 23700 1 1 1 1 1 2 2 23702 1 1 1 1 1 2 2 23712 1 1 1 1 1 2 2 23713 1 1 1 1 1 2 2 23718 1 1 1 1 1 2 2 23720 1 1 1 1 1 2 2 23743 1 1 1 1 1 2 2 23747 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 21 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3675 2 2 2 1 1 1 1 13695 2 2 2 1 1 1 1 13700 2 2 2 1 1 1 1 13702 2 2 2 1 1 1 1 13712 2 2 2 1 1 1 1 13713 2 2 2 1 1 1 1 13718 2 2 2 1 1 1 1 13720 2 2 2 1 1 1 1 13743 2 2 2 1 1 1 1 13747 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 22 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3674 1 1 1 1 13701 1 2 1 1 13708 1 1 1 1 13711 2* 1 1 1 13722 1 1 1 1 13726 1 1 1 1 13727 1 1 1 1 13731 1 1 1 1 13734 1 1 1 1 13756 2 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 23 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3674 1 1 1 1 1 2 2 23701 1 1 1 1 1 2 2 23708 1 1 1 1 1 2 2 23711 1 1 1 1 1 2 2 23722 1 1 1 1 1 2 2 23726 1 1 1 1 1 2 2 23727 1 1 1 1 1 2 2 23731 1 1 1 1 1 2 2 23734 1 1 1 1 1 2 2 23756 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 24 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3674 2 2 2 1 1 1 1 13701 2 2 2 1 1 1 1 13708 2 2 2 1 1 1 1 13711 2 2 2 1 1 1 1 13722 2 2 2 1 1 1 1 13726 2 2 2 1 1 1 1 13727 2 2 2 1 1 1 1 13731 2 2 2 1 1 1 1 13734 2 2 2 1 1 1 1 13756 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 25 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3676 1 1 1 1 13678 1 1 1 1 13709 1 1 1 1 13716 1 1 1 1 13732 1 1 1 1 13739 1 1 1 1 13745 1 1 1 1 13746 1 1 1 1 13751 1 1 1 1 13754 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 26 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3676 1 1 1 1 1 2 2 23678 1 1 1 1 1 2 2 23709 1 1 1 1 1 2 2 23716 1 1 1 1 1 2 2 23732 1 1 1 1 1 2 2 23739 1 1 1 1 1 2 2 23745 1 1 1 1 1 2 2 23746 1 1 1 1 1 2 2 23751 1 1 1 1 1 2 2 23754 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 27 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3676 2 2 2 1 1 1 1 13678 2 2 2 1 1 1 1 13709 2 2 2 1 1 1 1 13716 2 2 2 1 1 1 1 13732 2 2 2 1 1 1 1 13739 2 2 2 1 1 1 1 13745 2 2 2 1 1 1 1 13746 2 2 2 1 1 1 1 13751 2 2 2 1 1 1 1 13754 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 28 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3673 1 1 1 1 13679 1 1 1 1 13680 1 1 1 1 13685 1 1 1 1 13689 1 1 1 1 13698 1 1 1 1 13721 2 1 1 1 13730 1 1 1 1 13742 1 1 1 1 13753 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 29 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3673 1 1 1 1 1 2 2 23679 1 1 1 1 1 2 2 23680 1 1 1 1 1 2 2 23685 1 1 1 1 1 2 2 23689 1 1 1 1 1 2 2 23698 1 1 1 1 1 2 2 23721 1 1 1 1 1 2 2 23730 1 1 1 1 1 2 2 23742 1 1 1 1 1 2 2 23753 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A17 (HANDLING OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 30 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3673 2 2 2 1 1 1 1 13679 2 2 2 1 1 1 1 13680 2 2 2 1 1 1 1 13685 2 2 2 1 1 1 1 13689 2 2 2 1 1 1 1 13698 2 2 2 1 1 1 1 13721 2 2 2 1 1 1 1 13730 2 2 2 1 1 1 1 13742 2 2 2 1 1 1 1 13753 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE PFOBv3.25 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3774 1 1 1 1 13776 1 1 1 1 13780 2* 2* 1 1 13787 1 1 1 1 13803 1 1 1 1 13826 1 1 1 1 13828 1 1 1 1 13832 1 1 1 1 13837 2 2 1 1 13843 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3774 1 1 1 1 1 2 2 23776 1 1 1 1 1 2 2 23780 1 1 1 1 1 2 2 23787 1 1 1 1 1 2 2 23803 1 1 1 1 1 2 2 23826 1 1 1 1 1 2 2 23828 1 1 1 1 1 2 2 23832 1 1 1 1 1 2 2 23837 1 1 1 1 1 2 2 23843 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3774 2 2 2 1 1 1 1 13776 2 2 2 1 1 1 1 13780 2 2 2 1 1 1 1 13787 2 2 2 1 1 1 1 13803 2 2 2 1 1 1 1 13826 2 2 2 1 1 1 1 13828 2 1 2 1 1 1 1 13832 2 2 2 1 1 1 1 13837 2 2 2 1 1 1 1 13843 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3769 1 1 1 1 13772 1 1 1 1 13773 1 1 1 1 13781 1 1 1 1 13800 1 1 1 1 13805 1 1 1 1 13816 1 1 1 1 13818 1 2 1 1 13845 1 1 1 1 13846 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3769 1 1 1 1 1 2 2 23772 1 1 1 1 1 2 2 23773 1 1 1 1 1 2 2 23781 1 1 1 1 1 2 2 23800 1 1 1 1 1 2 2 23805 1 1 1 1 1 2 2 23816 1 1 1 1 1 2 2 23818 1 1 1 1 1 2 2 23845 1 1 1 1 1 2 2 23846 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3769 2 2 2 1 1 1 1 13772 2 2 2 1 1 1 1 13773 2 2 2 1 1 1 1 13781 2 2 2 1 1 1 1 13800 2 2 2 1 1 1 1 13805 2 2 2 1 1 1 1 13816 2 2 2 1 1 1 1 13818 2 2 2 1 1 1 1 13845 2 2 2 1 1 1 1 13846 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3762 1 2 1 1 13768 1 1 1 1 13786 1 1 1 1 13788 1 1 1 1 13813 1 1 1 1 13819 1 1 1 1 13825 1 1 1 1 13833 1 1 1 1 13841 1 1 1 1 13842 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3762 1 1 1 1 1 2 2 23768 1 1 1 1 1 2 2 23786 1 1 1 1 1 2 2 23788 1 1 1 1 1 2 2 23813 1 1 1 1 1 2 2 23819 1 1 1 1 1 2 2 23825 1 1 1 1 1 2 2 23833 1 1 1 1 1 2 2 23841 1 1 1 1 1 2 2 23842 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3762 2 2 2 1 1 1 1 13768 2 2 2 1 1 1 1 13786 2 2 2 1 1 1 1 13788 2 2 2 1 1 1 1 13813 2 2 2 1 1 1 1 13819 2 2 2 1 1 1 1 13825 2 2 2 1 1 1 1 13833 2 2 2 1 1 1 1 13841 2 2 2 1 1 1 1 13842 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3760 2 1 1 1 13779 1 1 1 1 13782 1 1 1 1 13784 1 1 1 1 13793 1 1 1 1 13794 1 1 1 1 13820 2 1 1 1 13821 1 2 1 1 13838 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3760 1 2 1 1 1 2 2 23779 1 1 1 1 1 2 2 23782 1 1 1 1 1 2 2 23784 1 1 1 1 1 2 2 23793 1 1 1 1 1 2 2 23794 1 1 1 1 1 2 2 23820 1 1 1 1 1 2 2 23821 1 1 1 1 1 2 2 23838 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3760 2 1 2 1 1 1 1 13779 2 2 2 1 1 1 1 13782 2 2 2 1 1 1 1 13784 2 2 2 1 1 1 1 13793 2 2 2 1 1 1 1 13794 2 2 2 1 1 1 1 13820 2 2 2 1 1 1 1 13821 2 2 2 1 1 1 1 13838 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3763 1 1 1 1 13767 1 1 1 1 13771 2 1 1 1 13775 1 1 1 1 13795 1 1 1 1 13804 1 1 1 1 13814 1 1 1 1 13817 1 1 1 1 13822 1 1 1 1 13839 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3763 1 1 1 1 1 2 2 23767 1 1 1 1 1 2 2 23771 1 1 1 1 1 2 2 23775 1 1 1 1 1 2 2 23795 1 1 1 1 1 2 2 23804 1 1 1 1 1 2 2 23814 1 1 1 1 1 2 2 23817 1 1 1 1 1 2 2 23822 1 1 1 1 1 2 2 23839 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3763 2 2 2 1 1 1 1 13767 2 2 2 1 1 1 1 13771 2 2 2 1 1 1 1 13775 2 2 2 1 1 1 1 13795 2 2 2 1 1 1 1 13804 2 2 2 1 1 1 1 13814 2 2 2 1 1 1 1 13817 2 2 2 1 1 1 1 13822 2 2 2 1 1 1 1 13839 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3677 1 1 1 1 13686 1 1 1 1 13694 1 1 1 1 13696 1 1 1 1 13704 1 1 1 1 13714 1 1 1 1 13725 1 1 1 1 13738 1 1 1 1 13744 1 1 1 1 13757 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3677 1 1 1 1 1 2 2 23686 1 1 1 1 1 2 2 23694 1 1 1 1 1 2 2 23696 1 1 1 1 1 2 2 23704 1 1 1 1 1 2 2 23714 1 1 1 1 1 2 2 23725 1 1 1 1 1 2 2 23738 1 1 1 1 1 2 2 23744 1 1 1 1 1 2 2 23757 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3677 2 2 2 1 1 1 1 13686 2 2 2 1 1 1 1 13694 2 2 2 1 1 1 1 13696 2 2 2 1 1 1 1 13704 2 2 2 1 1 1 1 13714 2 2 2 1 1 1 1 13725 2 2 2 1 1 1 1 13738 2 2 2 1 1 1 1 13744 2 2 2 1 1 1 1 13757 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3675 1 1 1 1 13695 1 1 1 1 13700 1 1 1 1 13702 1 1 1 1 13712 1 1 1 1 13713 1 1 1 1 13718 1 1 1 1 13720 1 1 1 1 13743 1 1 1 1 13747 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3675 1 1 1 1 1 2 2 23695 1 1 1 1 1 2 2 23700 1 1 1 1 1 2 2 23702 1 1 1 1 1 2 2 23712 1 1 1 1 1 2 2 23713 1 1 1 1 1 2 2 23718 1 1 1 1 1 2 2 23720 1 1 1 1 1 2 2 23743 1 1 1 1 1 2 2 23747 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 21 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3675 2 2 2 1 1 1 1 13695 2 2 2 1 1 1 1 13700 2 2 2 1 1 1 1 13702 2 2 2 1 1 1 1 13712 2 2 2 1 1 1 1 13713 2 2 2 1 1 1 1 13718 2 2 2 1 1 1 1 13720 2 2 2 1 1 1 1 13743 2 2 2 1 1 1 1 13747 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 22 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3674 1 1 1 1 13701 1 1 1 1 13708 1 1 1 1 13711 1 1 1 1 13722 1 1 1 1 13726 1 1 1 1 13727 1 1 1 1 13731 1 1 1 1 13734 1 1 1 1 13756 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 23 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3674 1 1 1 1 1 2 2 23701 1 1 1 1 1 2 2 23708 1 1 1 1 1 2 2 23711 1 1 1 1 1 2 2 23722 1 1 1 1 1 2 2 23726 1 1 1 1 1 2 2 23727 1 1 1 1 1 2 2 23731 1 1 1 1 1 2 2 23734 1 1 1 1 1 2 2 23756 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 24 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3674 2 2 2 1 1 1 1 13701 2 2 2 1 1 1 1 13708 2 2 2 1 1 1 1 13711 2 2 2 1 1 1 1 13722 2 2 2 1 1 1 1 13726 2 2 2 1 1 1 1 13727 2 1 2 1 1 1 1 13731 2 2 2 1 1 1 1 13734 2 2 2 1 1 1 1 13756 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 25 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3676 1 1 1 1 13678 1 1 1 1 13709 1 1 1 1 13716 1 1 1 1 13732 1 1 1 1 13739 1 1 1 1 13745 1 1 1 1 13746 1 1 1 1 13751 1 1 1 1 13754 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 26 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3676 1 1 1 1 1 2 2 23678 1 1 1 1 1 2 2 23709 1 1 1 1 1 2 2 23716 1 1 1 1 1 2 2 23732 1 1 1 1 1 2 2 23739 1 1 1 1 1 2 2 23745 1 1 1 1 1 2 2 23746 1 1 1 1 1 2 2 23751 1 1 1 1 1 2 2 23754 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 27 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3676 2 2 2 1 1 1 1 13678 2 2 2 1 1 1 1 13709 2 2 2 1 1 1 1 13716 2 2 2 1 1 1 1 13732 2 2 2 1 1 1 1 13739 2 2 2 1 1 1 1 13745 2 2 2 1 1 1 1 13746 2 2 2 1 1 1 1 13751 2 2 2 1 1 1 1 13754 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 28 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL EASE OF REMOVAL EASE OF HANDLINGNUMBER FROM CAGE ANIMAL IN HAND LACRIMATION CHROMODACRYORRHEA SALIVATION-----------------------------------------------------------------------------------------------------------------------------------3673 1 1 1 1 13679 1 1 1 1 13680 1 1 1 1 13685 1 1 1 1 13689 1 1 1 1 13698 1 1 1 1 13721 1 1 1 1 13730 1 1 1 1 13742 1 1 1 1 13753 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 29 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- RED DEPOSITSANIMAL FUR PALPEBRAL RESPIRATORY RESPIRATORY --------------------------------NUMBER PILOERECTION APPEARANCE CLOSURE RATE CHARACTER EYES NOSE MOUTH-----------------------------------------------------------------------------------------------------------------------------------3673 1 1 1 1 1 2 2 23679 1 1 1 1 1 2 2 23680 1 1 1 1 1 2 2 23685 1 1 1 1 1 1 2 23689 1 1 1 1 1 2 2 23698 1 1 1 1 1 2 2 23721 1 1 1 1 1 2 2 23730 1 1 1 1 1 2 2 23742 1 1 1 1 1 2 2 23753 1 1 1 1 1 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A18 (HANDLING OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 30 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAHANDLING OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- CRUSTY DEPOSITS COLORANIMAL --------------------- ------------------------------- EYE MUSCLENUMBER EYES NOSE MOUTH MUCOUS MEMBRANES EYES SKIN PROMINENCE TONE-----------------------------------------------------------------------------------------------------------------------------------3673 2 2 2 1 1 1 1 13679 2 2 2 1 1 1 1 13680 2 2 2 1 1 1 1 13685 2 2 2 1 1 1 1 13689 2 2 2 1 1 1 1 13698 2 2 2 1 1 1 1 13721 2 2 2 1 1 1 1 13730 2 2 2 1 1 1 1 13742 2 2 2 1 1 1 1 13753 2 2 2 1 1 1 1 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE PFOBv3.25 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3774 1.8 1 1 1 1 1 1 33776 1.1 1 1 1 1 1 1 33780 0.7 1 1 1 1 1 1 33787 0.2 1 1 1 1 1 1 33803 0.7 1 1 1 1 1 1 33826 1.1 1 1 1 1 1 1 33828 2.5 1 1 1 1 1 1 33832 0.3 1 1 1 1 1 1 33837 1.3 1 1 1 1 1 1 33843 0.7 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 1.0S.D. 0.70 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3774 1 1.0 0.0 0.0 0.0 0.03776 1 7.0 0.0 1.0 0.0 0.03780 1 10.0 0.0 0.0 0.0 0.03787 1 12.0 0.0 0.0 0.0 0.03803 1 3.0 0.0 0.0 0.0 0.03826 1 10.0 0.0 0.0 0.0 0.03828 1 7.0 0.0 0.0 1.0 0.03832 1 6.0 0.0 0.0 0.0 0.03837 1 8.0 0.0 1.0 1.0 0.03843 1 7.0 0.0 0.0 1.0 1.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 7.1 0.0 0.2 0.3 0.1S.D. 3.28 0.00 0.42 0.48 0.32 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3769 0.6 1 1 1 1 1 1 33772 0.5 1 1 1 1 1 1 33773 0.2 1 1 1 1 1 1 33781 1.0 1 1 1 1 1 1 33800 0.6 1 1 1 1 1 1 33805 3.2 1 1 1 1 1 1 33816 0.8 1 1 1 1 1 1 33818 1.2 1 1 1 1 1 1 33845 0.8 1 1 1 1 1 1 33846 0.3 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.9S.D. 0.86 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3769 1 12.0 0.0 1.0 1.0 1.03772 1 7.0 0.0 1.0 0.0 0.03773 1 7.0 0.0 0.0 0.0 0.03781 1 10.0 0.0 0.0 0.0 0.03800 1 6.0 0.0 0.0 0.0 3.03805 1 9.0 0.0 0.0 0.0 0.03816 1 9.0 0.0 1.0 1.0 0.03818 1 5.0 0.0 0.0 0.0 0.03845 1 6.0 0.0 0.0 1.0 0.03846 1 9.0 0.0 0.0 0.0 1.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 8.0 0.0 0.3 0.3 0.5S.D. 2.16 0.00 0.48 0.48 0.97 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3762 0.6 1 1 1 1 1 1 33768 0.9 1 1 1 1 1 1 33786 0.2 1 1 1 1 1 1 33788 1.0 1 1 1 1 1 1 33813 0.9 1 1 1 1 1 1 33819 2.0 1 1 1 1 1 1 33825 0.2 1 1 1 1 1 1 33833 0.8 1 1 1 1 1 1 33841 1.0 1 1 1 1 1 1 33842 0.9 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.9S.D. 0.50 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3762 1 13.0 0.0 0.0 0.0 1.03768 1 10.0 0.0 0.0 0.0 0.03786 1 11.0 0.0 0.0 1.0 0.03788 1 7.0 0.0 0.0 0.0 0.03813 1 11.0 0.0 0.0 1.0 0.03819 1 7.0 0.0 0.0 0.0 0.03825 1 7.0 0.0 0.0 0.0 0.03833 1 4.0 0.0 1.0 0.0 0.03841 1 6.0 0.0 0.0 0.0 0.03842 1 5.0 0.0 0.0 1.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 8.1 0.0 0.1 0.3 0.1S.D. 2.96 0.00 0.32 0.48 0.32 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3760 1.9 1 1 1 1 1 1 33770 0.7 1 1 1 1 1 1 33779 0.3 1 1 1 1 1 1 33782 0.3 1 1 1 1 1 1 33784 0.6 1 1 1 1 1 1 33793 1.0 1 1 1 1 1 1 33794 1.7 1 1 1 1 1 1 33820 0.8 1 1 1 1 1 1 33821 0.9 1 1 1 1 1 1 33838 0.8 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.9S.D. 0.53 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3760 1 0.0 0.0 0.0 1.0 1.03770 1 2.0 0.0 0.0 0.0 0.03779 1 2.0 0.0 0.0 0.0 0.03782 1 8.0 0.0 1.0 0.0 0.03784 1 4.0 0.0 0.0 1.0 2.03793 1 4.0 0.0 1.0 0.0 0.03794 1 18.0 0.0 0.0 1.0 0.03820 1 3.0 0.0 0.0 0.0 0.03821 1 10.0 0.0 0.0 1.0 0.03838 1 9.0 0.0 0.0 0.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 6.0 0.0 0.2 0.4 0.3S.D. 5.35 0.00 0.42 0.52 0.67 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3763 0.6 1 1 1 1 1 1 33767 1.0 1 1 1 1 1 1 33771 3.6 1 1 1 1 1 1 33775 0.3 1 1 1 1 1 1 33795 2.3 1 1 1 1 1 1 33804 0.7 1 1 1 1 1 1 33814 1.1 1 1 1 1 1 1 33817 0.8 1 1 1 1 1 1 33822 0.3 1 1 1 1 1 1 33839 0.6 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 1.1S.D. 1.04 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3763 1 8.0 0.0 2.0 0.0 0.03767 1 10.0 0.0 0.0 0.0 0.03771 1 5.0 0.0 0.0 2.0 6.03775 1 8.0 0.0 0.0 1.0 0.03795 1 6.0 0.0 0.0 0.0 0.03804 1 3.0 0.0 0.0 1.0 2.03814 1 6.0 0.0 1.0 0.0 0.03817 1 8.0 0.0 0.0 1.0 0.03822 1 9.0 0.0 0.0 0.0 0.03839 1 2.0 0.0 0.0 0.0 1.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 6.5 0.0 0.3 0.5 0.9S.D. 2.59 0.00 0.67 0.71 1.91 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3677 0.3 1 1 1 1 1 1 33686 1.0 1 1 1 1 1 1 33694 0.5 1 1 1 1 1 1 33696 0.2 1 1 1 1 1 1 33704 1.4 1 1 1 1 1 1 33714 1.0 1 1 1 1 1 1 33725 0.6 1 1 1 1 1 1 33738 0.7 1 1 1 1 1 1 33744 0.7 1 1 1 1 1 1 33757 0.4 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.7S.D. 0.37 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3677 1 8.0 0.0 0.0 0.0 0.03686 1 9.0 0.0 0.0 1.0 0.03694 1 13.0 0.0 0.0 0.0 0.03696 1 8.0 0.0 1.0 0.0 0.03704 1 10.0 0.0 0.0 0.0 0.03714 1 5.0 0.0 0.0 0.0 0.03725 1 11.0 0.0 1.0 1.0 0.03738 1 7.0 0.0 0.0 0.0 0.03744 1 11.0 0.0 0.0 0.0 0.03757 1 9.0 0.0 0.0 0.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 9.1 0.0 0.2 0.2 0.0S.D. 2.28 0.00 0.42 0.42 0.00 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3675 0.7 1 1 1 1 1 1 33695 0.2 1 1 1 1 1 1 33700 0.6 1 1 1 1 1 1 33702 0.8 1 1 1 1 1 1 33712 0.2 1 1 1 1 1 1 33713 1.8 1 1 1 1 1 1 33718 1.2 1 1 1 1 1 1 33720 1.2 1 1 1 1 1 1 33743 0.7 1 1 1 1 1 1 33747 1.0 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.8S.D. 0.49 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3675 1 11.0 0.0 0.0 0.0 0.03695 1 3.0 0.0 0.0 0.0 0.03700 1 2.0 0.0 1.0 0.0 0.03702 1 8.0 0.0 0.0 0.0 0.03712 1 11.0 0.0 0.0 0.0 0.03713 1 5.0 0.0 0.0 0.0 0.03718 1 7.0 0.0 0.0 1.0 0.03720 1 11.0 0.0 0.0 0.0 0.03743 1 12.0 0.0 0.0 0.0 0.03747 1 10.0 0.0 0.0 1.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 8.0 0.0 0.1 0.2 0.0S.D. 3.62 0.00 0.32 0.42 0.00 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3674 0.7 1 1 1 1 1 1 33701 0.8 1 1 1 1 1 1 33708 1.0 1 1 1 1 1 1 33711 0.2 1 1 1 1 1 1 33722 0.5 1 1 1 1 1 1 33726 0.5 1 1 1 1 1 1 33727 0.2 1 1 1 1 1 1 33731 0.9 1 1 1 1 1 1 33734 0.8 1 1 1 1 1 1 33756 0.6 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.6S.D. 0.27 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3674 1 10.0 0.0 1.0 1.0 0.03701 1 14.0 0.0 0.0 0.0 0.03708 1 0.0 0.0 0.0 0.0 0.03711 1 10.0 0.0 0.0 0.0 0.03722 1 11.0 0.0 0.0 1.0 0.03726 1 7.0 0.0 0.0 0.0 0.03727 1 6.0 0.0 0.0 0.0 0.03731 1 10.0 0.0 0.0 0.0 0.03734 1 13.0 0.0 1.0 0.0 0.03756 1 11.0 0.0 0.0 0.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 9.2 0.0 0.2 0.2 0.0S.D. 4.02 0.00 0.42 0.42 0.00 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3676 0.2 1 1 1 1 1 1 33678 0.7 1 1 1 1 1 1 33709 0.6 1 1 1 1 1 1 33716 0.7 1 1 1 1 1 1 33732 0.6 1 1 1 1 1 1 33739 0.8 1 1 1 1 1 1 33745 0.9 1 1 1 1 1 1 33746 0.7 1 1 1 1 1 1 33751 0.4 1 1 1 1 1 1 33754 0.2 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.6S.D. 0.24 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3676 1 7.0 0.0 0.0 0.0 0.03678 1 10.0 0.0 0.0 0.0 0.03709 1 9.0 0.0 0.0 0.0 1.03716 1 3.0 0.0 1.0 1.0 0.03732 1 10.0 0.0 0.0 0.0 0.03739 1 7.0 0.0 1.0 1.0 0.03745 1 9.0 0.0 1.0 0.0 0.03746 1 6.0 0.0 0.0 0.0 0.03751 1 11.0 0.0 0.0 0.0 0.03754 1 7.0 0.0 0.0 1.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 7.9 0.0 0.3 0.3 0.1S.D. 2.38 0.00 0.48 0.48 0.32 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3673 1.5 1 1 1 1 1 1 33679 1.2 1 1 1 1 1 1 33680 0.5 1 1 1 1 1 1 33685 0.3 1 1 1 1 1 1 33689 0.8 1 1 1 1 1 1 33698 0.6 1 1 1 1 1 1 33721 0.7 1 1 1 1 1 1 33730 0.7 1 1 1 1 1 1 33742 0.8 1 1 1 1 1 1 33753 0.3 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.7S.D. 0.37 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A19 (OPEN FIELD OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3673 1 8.0 0.0 0.0 0.0 0.03679 1 15.0 0.0 0.0 0.0 0.03680 1 10.0 0.0 0.0 0.0 0.03685 1 10.0 0.0 0.0 0.0 0.03689 1 10.0 0.0 0.0 0.0 0.03698 1 13.0 0.0 0.0 0.0 0.03721 1 11.0 0.0 0.0 0.0 0.03730 1 9.0 0.0 0.0 1.0 0.03742 1 11.0 0.0 0.0 0.0 0.03753 1 9.0 0.0 0.0 0.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 10.6 0.0 0.0 0.1 0.0S.D. 2.07 0.00 0.00 0.32 0.00 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE PFOBv3.25 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3774 0.3 1 1 1 1 1 1 33776 0.9 1 1 1 1 1 1 33780 0.3 1 1 1 1 1 1 33787 0.9 1 1 1 1 1 1 33803 1.4 1 1 1 1 1 1 33826 0.6 1 1 1 1 1 1 33828 0.9 1 1 1 1 1 1 33832 0.9 1 1 1 1 1 1 33837 1.4 1 1 1 1 1 1 33843 0.6 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.8S.D. 0.39 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3774 1 1.0 0.0 0.0 0.0 2.03776 1 8.0 0.0 0.0 0.0 0.03780 1 1.0 0.0 0.0 1.0 5.03787 1 13.0 0.0 0.0 0.0 0.03803 1 8.0 0.0 0.0 0.0 0.03826 1 18.0 0.0 0.0 0.0 0.03828 1 7.0 0.0 0.0 0.0 0.03832 1 10.0 0.0 0.0 1.0 0.03837 1 7.0 0.0 0.0 1.0 0.03843 1 6.0 0.0 0.0 0.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 7.9 0.0 0.0 0.3 0.7S.D. 5.09 0.00 0.00 0.48 1.64 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3769 0.6 1 1 1 1 1 1 33772 0.6 1 1 1 1 1 1 33773 0.7 1 1 1 1 1 1 33781 0.9 1 1 1 1 1 1 33800 0.5 1 1 1 1 1 1 33805 0.8 1 1 1 1 1 1 33816 0.3 1 1 1 1 1 1 33818 1.1 1 1 1 1 1 1 33845 0.3 1 1 1 1 1 1 33846 0.8 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.7S.D. 0.25 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3769 1 11.0 0.0 0.0 1.0 0.03772 1 8.0 0.0 0.0 1.0 0.03773 1 10.0 0.0 0.0 1.0 0.03781 1 6.0 0.0 0.0 0.0 0.03800 1 2.0 0.0 0.0 1.0 7.03805 1 7.0 0.0 0.0 0.0 0.03816 1 2.0 0.0 1.0 0.0 0.03818 1 7.0 0.0 0.0 0.0 0.03845 1 10.0 0.0 0.0 1.0 0.03846 1 13.0 0.0 0.0 1.0 4.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 7.6 0.0 0.1 0.6 1.1S.D. 3.63 0.00 0.32 0.52 2.42 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3762 0.7 1 1 1 1 1 1 33768 1.5 1 1 1 1 1 1 33786 0.9 1 1 1 1 1 1 33788 1.0 1 1 1 1 1 1 33813 0.2 1 1 1 1 1 1 33819 0.9 1 1 1 1 1 1 33825 1.0 1 1 1 1 1 1 33833 0.3 1 1 1 1 1 1 33841 0.7 1 1 1 1 1 1 33842 0.8 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.8S.D. 0.37 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3762 1 8.0 0.0 1.0 0.0 0.03768 1 5.0 0.0 0.0 1.0 0.03786 1 14.0 0.0 0.0 1.0 0.03788 1 9.0 0.0 0.0 1.0 0.03813 1 14.0 0.0 0.0 1.0 0.03819 1 10.0 0.0 0.0 1.0 0.03825 1 13.0 0.0 0.0 1.0 0.03833 1 4.0 0.0 0.0 1.0 0.03841 1 11.0 0.0 0.0 1.0 0.03842 1 8.0 0.0 0.0 1.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 9.6 0.0 0.1 0.9 0.0S.D. 3.50 0.00 0.32 0.32 0.00 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3760 1.5 1 1 1 1 1 1 33779 0.7 1 1 1 1 1 1 33782 1.1 1 1 1 1 1 1 33784 0.9 1 1 1 1 1 1 33793 1.4 1 1 1 1 1 1 33794 1.0 1 1 1 1 1 1 33820 0.7 1 1 1 1 1 1 33821 1.5 1 1 1 1 1 1 33838 0.3 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 1.0S.D. 0.41 N 9OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3760 1 11.0 0.0 0.0 0.0 0.03779 1 2.0 0.0 1.0 0.0 0.03782 1 8.0 0.0 0.0 0.0 0.03784 1 0.0 0.0 0.0 1.0 5.03793 1 10.0 0.0 0.0 1.0 0.03794 1 7.0 0.0 0.0 1.0 0.03820 1 4.0 0.0 1.0 1.0 2.03821 1 12.0 0.0 0.0 1.0 0.03838 1 10.0 0.0 0.0 0.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 7.1 0.0 0.2 0.6 0.8S.D. 4.23 0.00 0.44 0.53 1.72 N 9 9 9 9 9OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3763 0.8 1 1 1 1 1 1 33767 0.2 1 1 1 1 1 1 33771 0.5 1 1 1 1 1 1 33775 0.5 1 1 1 1 1 1 33795 1.0 1 1 1 1 1 1 33804 0.8 1 1 1 1 1 1 33814 0.7 1 1 1 1 1 1 33817 0.9 1 1 1 1 1 1 33822 0.7 1 1 1 1 1 1 33839 0.2 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.6S.D. 0.28 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3763 1 14.0 0.0 0.0 1.0 0.03767 1 20.0 0.0 0.0 3.0 0.03771 1 11.0 0.0 1.0 1.0 0.03775 1 10.0 0.0 0.0 1.0 0.03795 1 8.0 0.0 0.0 0.0 0.03804 1 10.0 0.0 0.0 0.0 0.03814 1 2.0 0.0 0.0 0.0 0.03817 1 3.0 0.0 0.0 1.0 0.03822 1 7.0 0.0 0.0 0.0 0.03839 1 5.0 0.0 1.0 1.0 3.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 9.0 0.0 0.2 0.8 0.3S.D. 5.35 0.00 0.42 0.92 0.95 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3677 0.6 1 1 1 1 1 1 33686 0.6 1 1 1 1 1 1 33694 1.1 1 1 1 1 1 1 33696 0.7 1 1 1 1 1 1 33704 0.2 1 1 1 1 1 1 33714 0.6 1 1 1 1 1 1 33725 0.5 1 1 1 1 1 1 33738 0.4 1 1 1 1 1 1 33744 0.2 1 1 1 1 1 1 33757 0.4 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.5S.D. 0.26 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3677 1 11.0 0.0 0.0 0.0 0.03686 1 8.0 0.0 0.0 0.0 0.03694 1 11.0 0.0 0.0 0.0 0.03696 1 17.0 0.0 0.0 0.0 0.03704 1 11.0 0.0 1.0 0.0 0.03714 1 22.0 0.0 0.0 0.0 0.03725 1 10.0 0.0 0.0 0.0 0.03738 1 11.0 0.0 0.0 0.0 0.03744 1 10.0 0.0 0.0 0.0 0.03757 1 12.0 0.0 0.0 0.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 12.3 0.0 0.1 0.0 0.0S.D. 4.11 0.00 0.32 0.00 0.00 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3675 0.2 1 1 1 1 1 1 33695 1.2 1 1 1 1 1 1 33700 0.6 1 1 1 1 1 1 33702 0.2 1 1 1 1 1 1 33712 1.4 1 1 1 1 1 1 33713 0.6 1 1 1 1 1 1 33718 0.8 1 1 1 1 1 1 33720 0.5 1 1 1 1 1 1 43743 0.7 1 1 1 1 1 1 33747 0.6 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.7S.D. 0.38 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3675 1 17.0 0.0 0.0 0.0 0.03695 1 8.0 0.0 0.0 0.0 0.03700 1 10.0 0.0 0.0 0.0 0.03702 1 18.0 0.0 0.0 0.0 0.03712 1 10.0 0.0 0.0 0.0 0.03713 1 13.0 0.0 1.0 0.0 0.03718 1 15.0 0.0 0.0 0.0 0.03720 1 25.0 0.0 1.0 0.0 0.03743 1 16.0 0.0 0.0 0.0 0.03747 1 15.0 0.0 1.0 0.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 14.7 0.0 0.3 0.0 0.0S.D. 4.90 0.00 0.48 0.00 0.00 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3674 0.4 1 1 1 1 1 1 33701 0.6 1 1 1 1 1 1 33708 0.5 1 1 1 1 1 1 33711 0.6 1 1 1 1 1 1 33722 0.4 1 1 1 1 1 1 33726 0.5 1 1 1 1 1 1 33727 0.6 1 1 1 1 1 1 33731 0.6 1 1 1 1 1 1 33734 0.3 1 1 1 1 1 1 33756 0.6 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.5S.D. 0.11 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3674 1 9.0 0.0 0.0 0.0 0.03701 1 17.0 0.0 0.0 0.0 0.03708 1 15.0 0.0 0.0 0.0 0.03711 1 14.0 0.0 0.0 0.0 0.03722 1 4.0 0.0 0.0 2.0 0.03726 1 20.0 0.0 1.0 0.0 0.03727 1 15.0 0.0 0.0 0.0 0.03731 1 16.0 0.0 0.0 0.0 0.03734 1 18.0 0.0 0.0 0.0 0.03756 1 9.0 0.0 1.0 1.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 13.7 0.0 0.2 0.3 0.0S.D. 4.90 0.00 0.42 0.67 0.00 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3676 0.7 1 1 1 1 1 1 33678 0.7 1 1 1 1 1 1 33709 1.0 1 1 1 1 1 1 33716 0.6 1 1 1 1 1 1 33732 0.3 1 1 1 1 1 1 33739 0.7 1 1 1 1 1 1 33745 0.2 1 1 1 1 1 1 33746 0.6 1 1 1 1 1 1 43751 0.4 1 1 1 1 1 1 33754 0.7 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.6S.D. 0.23 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3676 1 14.0 0.0 0.0 0.0 0.03678 1 16.0 0.0 0.0 0.0 0.03709 1 12.0 0.0 0.0 0.0 0.03716 1 1.0 0.0 0.0 1.0 0.03732 1 11.0 0.0 0.0 0.0 0.03739 1 9.0 0.0 0.0 0.0 0.03745 1 12.0 0.0 0.0 0.0 0.03746 1 29.0 0.0 0.0 0.0 0.03751 1 9.0 0.0 0.0 0.0 0.03754 1 10.0 0.0 0.0 0.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 12.3 0.0 0.0 0.1 0.0S.D. 7.09 0.00 0.00 0.32 0.00 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- TIME TO CONVULSIONSANIMAL 1ST STEP -------------NUMBER (seconds) MOBILITY GAIT CLONIC TONIC TREMORS GAIT SCORE AROUSAL-----------------------------------------------------------------------------------------------------------------------------------3673 1.2 1 1 1 1 1 1 33679 0.6 1 1 1 1 1 1 33680 0.7 1 1 1 1 1 1 33685 0.6 1 1 1 1 1 1 33689 1.1 1 1 1 1 1 1 33698 0.2 1 1 1 1 1 1 33721 0.7 1 1 1 1 1 1 33730 0.6 1 1 1 1 1 1 33742 0.2 1 1 1 1 1 1 33753 0.5 1 1 1 1 1 1 3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.6S.D. 0.32 N 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A20 (OPEN FIELD OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAOPEN FIELD OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL BIZARRE/STEREO- REARING BACKING GROOMING URINATION DEFECATIONNUMBER TYPIC BEHAVIOR (counts) (counts) (counts) (counts) (counts)-----------------------------------------------------------------------------------------------------------------------------------3673 1 11.0 0.0 0.0 0.0 1.03679 1 12.0 0.0 0.0 0.0 0.03680 1 10.0 0.0 0.0 0.0 0.03685 1 15.0 0.0 0.0 0.0 0.03689 1 14.0 0.0 0.0 0.0 0.03698 1 15.0 0.0 0.0 0.0 0.03721 1 14.0 0.0 0.0 0.0 0.03730 1 15.0 0.0 0.0 1.0 0.03742 1 8.0 0.0 0.0 0.0 0.03753 1 9.0 0.0 0.0 1.0 0.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 12.3 0.0 0.0 0.2 0.1S.D. 2.67 0.00 0.00 0.42 0.32 N 10 10 10 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE PFOBv3.25 05/11/2009 R:09/23/2009

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3774 2 2 2 2 23776 2 2 2 2 23780 2 2 2 3* 23787 2 2 2 2 23803 2 2 2 2 23826 2 2 2 2 23828 2 2 2 2 23832 2 2 2 2 23837 2 2 2 2 23843 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3774 2 2 2 2 13776 2 2 2 2 13780 2 2 2 2 13787 2 2 2 2 13803 2 2 2 2 13826 2 2 2 2 13828 2 2 2 2 13832 2 2 2 2 13837 2 2 2 2 13843 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3769 2 2 2 2 23772 3 2 2 2 23773 2 2 2 2 23781 2 2 2 3 23800 2 2 2 2 23805 2 2 2 2 23816 2 2 2 2 23818 2 2 2 2 23845 1 2 2 2 23846 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3769 2 2 2 2 13772 2 2 2 2 13773 2 2 2 2 13781 2 2 2 2 13800 2 2 2 2 13805 2 2 2 2 13816 2 2 2 2 13818 2 2 2 2 13845 2 2 2 2 13846 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3762 2 2 2 2 23768 1 2 2 2 23786 2 2 2 2 23788 2 2 2 2 23813 2 2 2 2 23819 2 2 2 2 23825 2 2 2 2 23833 1 2 2 2 23841 2 2 2 2 23842 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3762 2 2 2 2 13768 2 2 2 2 13786 2 2 2 2 13788 2 2 2 2 13813 2 2 2 2 13819 2 2 2 2 13825 2 2 2 2 13833 2 2 2 2 13841 2 2 2 2 13842 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3760 2 2 2 2 23770 2 2 2 2 23779 2 2 2 2 23782 2 2 2 2 23784 1 2 2 2 23793 2 2 2 2 23794 2 2 2 2 23820 2 2 2 2 23821 2 2 2 2 23838 1 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3760 2 2 2 2 13770 2 2 2 2 13779 2 2 2 2 13782 2 2 2 2 13784 2 2 2 2 13793 2 2 2 2 13794 2 2 2 2 13820 2 2 2 2 13821 2 2 2 2 13838 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3763 2 2 2 2 23767 2 2 2 2 23771 2 2 2 2 23775 2 2 2 2 23795 2 2 2 2 23804 2 2 2 2 23814 2 2 2 2 23817 2 2 2 2 23822 2 2 2 2 23839 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3763 2 2 2 2 13767 2 2 2 2 13771 2 2 2 2 13775 2 2 2 2 13795 2 2 2 2 13804 2 2 2 2 13814 2 2 2 2 13817 2 2 2 2 13822 2 2 2 2 13839 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3677 2 2 2 2 23686 2 2 2 3* 23694 2 2 2 2 23696 2 2 2 2 23704 2 2 2 2 23714 3 3 2 2 23725 2 2 2 2 23738 2 2 2 2 23744 2 2 2 2 23757 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3677 2 2 2 2 13686 2 2 2 2 13694 2 2 2 2 13696 2 2 2 2 13704 2 2 2 2 13714 2 2 2 2 13725 2 2 2 2 13738 2 2 2 2 13744 2 2 2 2 13757 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3675 2 2 2 2 23695 2 2 2 2 23700 2 2 2 1 23702 2 2 2 2 23712 2 2 2 2 23713 2 2 2 3* 23718 2 2 2 2 23720 2 2 2 2 23743 2 2 2 2 23747 1 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3675 2 2 2 2 13695 2 2 2 2 13700 2 2 2 2 13702 2 2 2 2 13712 2 2 2 2 13713 2 2 2 2 13718 2 2 2 2 13720 2 2 2 2 13743 2 2 2 2 13747 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3674 2 2 2 2 23701 2 2 2 2 23708 2 2 2 2 23711 2 2 2 2 23722 2 2 2 2 23726 2 2 2 2 23727 2 2 2 2 23731 2 2 2 2 23734 2 2 2 2 23756 2 2 3 3 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3674 2 2 2 2 13701 2 2 2 2 13708 2 2 2 2 13711 2 2 2 2 13722 2 2 2 2 13726 2 2 2 2 13727 2 2 2 2 13731 2 2 2 2 13734 2 2 2 2 13756 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3676 2 2 2 2 23678 2 2 2 2 23709 2 2 2 2 23716 2 2 2 3* 23732 3 2 2 3 23739 2 2 2 2 23745 1 2 2 2 23746 2 2 2 2 23751 2 2 2 2 23754 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3676 2 2 2 2 13678 2 2 2 2 13709 2 2 2 2 13716 2 2 2 2 13732 2 2 2 2 13739 2 2 2 2 13745 2 2 2 2 13746 2 2 2 2 13751 2 2 2 2 13754 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3673 2 2 2 2 23679 2 2 2 3* 23680 2 2 2 2 23685 2 2 2 2 23689 2 2 2 2 23698 1 2 2 2 23721 3 2 2 2 23730 2 2 2 2 23742 2 2 2 2 23753 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A21 (SENSORY OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: PRETEST-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3673 2 2 2 2 13679 2 2 2 2 13680 2 2 2 2 13685 2 2 2 2 13689 2 2 2 2 13698 2 2 2 2 13721 2 2 2 2 13730 2 2 2 2 13742 2 2 2 2 13753 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE PFOBv3.25 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3774 2 2 2 2 23776 1 2 2 2 23780 2 2 2 2 23787 1 2 2 1 23803 2 2 2 2 23826 2 2 2 2 23828 2 2 2 2 23832 1 2 2 1 23837 2 2 2 2 23843 2 2 2 1 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3774 2 2 2 2 13776 2 2 2 2 13780 2 2 2 2 13787 2 2 2 2 13803 2 2 2 2 13826 2 2 2 2 13828 2 2 2 2 13832 2 2 2 2 13837 2 2 2 2 13843 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3769 2 2 2 2 23772 2 2 2 2 23773 2 2 2 2 23781 2 2 2 3 23800 2 2 2 2 23805 2 2 2 1 23816 2 2 2 2 23818 2 2 2 2 23845 2 2 2 2 23846 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3769 2 2 2 2 13772 2 2 2 2 13773 2 2 2 2 13781 2 2 2 2 13800 2 2 2 2 13805 2 2 2 2 13816 2 2 2 2 13818 2 2 2 2 13845 2 2 2 2 13846 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3762 2 2 2 2 23768 2 2 2 2 23786 2 2 2 2 23788 1 2 2 2 23813 2 2 2 2 23819 2 2 2 2 23825 1 2 2 2 23833 2 2 2 2 23841 2 2 2 2 23842 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3762 2 2 2 2 13768 2 2 2 2 13786 2 2 2 2 13788 2 2 2 2 13813 2 2 2 2 13819 2 2 2 2 13825 2 2 2 2 13833 2 2 2 2 13841 2 2 2 2 13842 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3760 2 2 2 2 23779 2 2 2 2 23782 2 2 2 2 23784 2 2 2 2 23793 2 2 2 2 23794 1 1 1 1 23820 2 2 2 2 23821 2 2 2 2 23838 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3760 2 2 2 2 13779 2 2 2 2 13782 2 2 2 2 13784 2 2 2 2 13793 2 2 2 2 13794 2 2 2 2 13820 2 2 2 2 13821 2 2 2 2 13838 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3763 2 2 2 2 23767 2 2 2 2 23771 2 2 2 3* 23775 2 2 2 3 23795 2 2 2 2 23804 2 2 2 1 23814 1 1 2 2 23817 1 2 2 2 23822 2 2 2 3* 23839 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3763 2 2 2 2 13767 2 2 2 2 13771 2 2 2 2 13775 2 2 2 2 13795 2 2 2 2 13804 2 2 2 2 13814 2 2 2 2 13817 2 2 2 2 13822 2 2 2 2 13839 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3677 2 2 2 2 23686 2 2 2 2 23694 2 2 2 3* 23696 2 2 2 2 23704 2 2 2 2 23714 2 2 2 2 23725 2 2 2 2 23738 2 2 2 2 23744 2 2 2 2 23757 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE* = ANIMAL VOCALIZED

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3677 2 2 2 2 13686 2 2 2 2 13694 2 2 2 2 13696 2 2 2 2 13704 2 2 2 2 13714 2 2 2 2 13725 2 2 2 2 13738 2 2 2 2 13744 2 2 2 2 13757 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3675 2 2 2 2 23695 2 2 2 2 23700 2 2 2 2 23702 2 2 2 2 23712 2 2 2 2 23713 1 1 2 2 23718 2 2 2 3 23720 2 2 2 3 23743 2 2 2 2 23747 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3675 2 2 2 2 13695 2 2 2 2 13700 2 2 2 2 13702 2 2 2 2 13712 2 2 2 2 13713 2 2 2 2 13718 2 2 2 2 13720 2 2 2 2 13743 2 2 2 2 13747 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3674 2 2 2 2 23701 2 2 2 2 23708 2 2 2 2 23711 2 2 2 2 23722 2 2 2 2 23726 2 2 2 2 23727 2 2 2 2 23731 2 2 2 2 23734 2 2 2 2 23756 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3674 2 2 2 2 13701 2 2 2 2 13708 2 2 2 2 13711 2 2 2 2 13722 2 2 2 2 13726 2 2 2 2 13727 2 2 2 2 13731 2 2 2 2 13734 2 2 2 2 13756 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3676 2 2 2 2 23678 2 2 2 2 23709 1 2 2 2 23716 2 2 2 2 23732 2 2 2 2 23739 2 2 2 3 23745 2 2 2 2 23746 2 2 2 2 23751 2 2 2 2 23754 2 2 2 3 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3676 2 2 2 2 13678 2 2 2 2 13709 2 2 2 2 13716 2 2 2 2 13732 2 2 2 2 13739 2 2 2 2 13745 2 2 2 2 13746 2 2 2 2 13751 2 2 2 2 13754 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL APPROACH TOUCH STARTLE TAIL PINCH OLFACTORYNUMBER RESPONSE RESPONSE RESPONSE RESPONSE ORIENTATION-----------------------------------------------------------------------------------------------------------------------------------3673 2 2 2 2 23679 2 2 2 2 23680 1 2 2 2 23685 2 2 2 2 23689 2 2 2 2 23698 2 2 2 2 23721 2 2 2 3 23730 2 2 2 2 23742 2 2 2 2 23753 2 2 2 2 2-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A22 (SENSORY OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATASENSORY OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: WEEK 3-----------------------------------------------------------------------------------------------------------------------------------ANIMAL PUPIL EYEBLINK FORELIMB HINDLIMB AIR RIGHTINGNUMBER RESPONSE RESPONSE EXTENSION EXTENSION REFLEX-----------------------------------------------------------------------------------------------------------------------------------3673 2 2 2 2 13679 2 2 2 2 13680 2 2 2 2 13685 2 2 2 2 13689 2 2 2 2 13698 2 2 2 2 13721 2 2 2 2 13730 2 2 2 2 13742 2 2 2 2 13753 2 2 2 2 1-----------------------------------------------------------------------------------------------------------------------------------OBSERVATION SCORE, UNLESS STATED OTHERWISE PFOBv3.25 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3774 3 800. 740. 545. 695. 133.3 235. 235. 175. 215. 34.63776 3 620. 655. 665. 647. 23.6 140. 190. 380. 237. 126.63780 3 470. 620. 475. 522. 85.2 105. 195. 130. 143. 46.53787 3 515. 560. 530. 535. 22.9 265. 305. 245. 272. 30.63803 3 680. 650. 620. 650. 30.0 200. 185. 230. 205. 22.93826 3 590. 755. 630. 658. 86.1 265. 235. 215. 238. 25.23828 3 520. 550. 525. 532. 16.1 150. 415. 190. 252. 142.93832 3 665. 725. 640. 677. 43.7 135. 185. 240. 187. 52.53837 3 365. 500. 810. 558. 228.2 175. 240. 235. 217. 36.23843 3 780. 645. 550. 658. 115.6 255. 205. 280. 247. 38.2-----------------------------------------------------------------------------------------------------------------------------------MEAN 613.2 221.3S.D. 67.78 37.01 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3774 120.0 71. 35. 53. 25.53776 70.0 48. 52. 50. 2.83780 120.0 30. 26. 28. 2.83787 11.0 37. 36. 37. 0.73803 98.0 39. 52. 46. 9.23826 120.0 56. 55. 56. 0.73828 19.0 43. 28. 36. 10.63832 8.0 75. 68. 72. 4.93837 33.0 50. 40. 45. 7.13843 25.0 48. 52. 50. 2.8-----------------------------------------------------------------------------------------------------------------------------------MEAN 62.4 47.3S.D. 48.33 12.23 N 10 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3769 3 660. 625. 430. 572. 123.9 455. 255. 265. 325. 112.73772 3 575. 520. 535. 543. 28.4 130. 210. 215. 185. 47.73773 3 655. 600. 625. 627. 27.5 205. 340. 310. 285. 70.93781 3 300. 820. 540. 553. 260.3 145. 335. 205. 228. 97.13800 3 850. 770. 615. 745. 119.5 305. 150. 235. 230. 77.63805 3 770. 720. 740. 743. 25.2 165. 110. 70. 115. 47.73816 3 395. 520. 605. 507. 105.6 310. 260. 105. 225. 106.93818 3 665. 630. 700. 665. 35.0 125. 100. 120. 115. 13.23845 3 225. 720. 620. 522. 261.7 95. 235. 155. 162. 70.23846 3 605. 580. 755. 647. 94.6 155. 145. 105. 135. 26.5-----------------------------------------------------------------------------------------------------------------------------------MEAN 612.4 200.5S.D. 86.97 71.10 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3769 120.0 68. 89. 79. 14.83772 26.0 61. 57. 59. 2.83773 120.0 72. 69. 71. 2.13781 120.0 75. 62. 69. 9.23800 120.0 77. 76. 77. 0.73805 24.0 60. 58. 59. 1.43816 32.0 60. 54. 57. 4.23818 120.0 52. 54. 53. 1.43845 120.0 48. 42. 45. 4.23846 37.0 62. 65. 64. 2.1-----------------------------------------------------------------------------------------------------------------------------------MEAN 83.9 63.3S.D. 46.73 10.77 N 10 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3762 3 730. 745. 425. 633. 180.6 285. 105. 215. 202. 90.73768 3 700. 525. 860. 695. 167.6 235. 335. 235. 268. 57.73786 3 620. 780. 585. 662. 104.0 130. 165. 450. 248. 175.53788 3 245. 575. 570. 463. 189.1 90. 110. 300. 167. 115.93813 3 775. 325. 350. 483. 252.9 390. 375. 255. 340. 74.03819 3 270. 640. 250. 387. 219.6 200. 130. 115. 148. 45.43825 3 905. 1030. 845. 927. 94.4 130. 165. 170. 155. 21.83833 3 405. 285. 465. 385. 91.7 150. 190. 145. 162. 24.73841 3 690. 640. 550. 627. 70.9 240. 170. 240. 217. 40.43842 3 935. 890. 970. 932. 40.1 120. 135. 100. 118. 17.6-----------------------------------------------------------------------------------------------------------------------------------MEAN 619.4 202.5S.D. 197.80 67.28 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3762 24.0 42. 42. 42. 0.03768 120.0 74. 62. 68. 8.53786 18.0 66. 68. 67. 1.43788 10.0 58. 51. 55. 4.93813 120.0 59. 58. 59. 0.73819 6.0 66. 57. 62. 6.43825 84.0 60. 59. 60. 0.73833 33.0 45. 38. 42. 4.93841 120.0 66. 61. 64. 3.53842 120.0 53. 55. 54. 1.4-----------------------------------------------------------------------------------------------------------------------------------MEAN 65.5 57.3S.D. 51.51 9.25 N 10 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3760 3 1170. 715. 940. 942. 227.5 275. 175. 180. 210. 56.33770 3 665. 645. 620. 643. 22.5 190. 165. 105. 153. 43.73779 3 690. 715. 585. 663. 69.0 105. 190. 335. 210. 116.33782 3 550. 630. 825. 668. 141.5 135. 115. 340. 197. 124.53784 3 575. 810. 725. 703. 119.0 110. 145. 325. 193. 115.43793 3 515. 725. 705. 648. 115.9 135. 270. 320. 242. 95.73794 3 375. 285. 365. 342. 49.3 80. 85. 180. 115. 56.33820 3 790. 520. 810. 707. 162.0 230. 155. 295. 227. 70.13821 3 585. 465. 570. 540. 65.4 140. 250. 160. 183. 58.63838 3 400. 405. 335. 380. 39.1 90. 85. 180. 118. 53.5-----------------------------------------------------------------------------------------------------------------------------------MEAN 623.6 184.8S.D. 171.52 43.32 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3760 120.0 83. 79. 81. 2.83770 120.0 64. 62. 63. 1.43779 38.0 65. 74. 70. 6.43782 120.0 103. 96. 100. 4.93784 120.0 37. 41. 39. 2.83793 47.0 62. 58. 60. 2.83794 120.0 48. 40. 44. 5.73820 37.0 78. 72. 75. 4.23821 3.0 36. 38. 37. 1.43838 22.0 42. 37. 40. 3.5-----------------------------------------------------------------------------------------------------------------------------------MEAN 74.7 60.9S.D. 49.12 21.06 N 10 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3763 3 765. 255. 445. 488. 257.7 75. 235. 190. 167. 82.53767 3 620. 730. 665. 672. 55.3 260. 360. 255. 292. 59.23771 3 735. 665. 1035. 812. 196.6 295. 370. 450. 372. 77.53775 3 595. 630. 450. 558. 95.4 95. 230. 100. 142. 76.53795 3 570. 820. 855. 748. 155.4 170. 155. 180. 168. 12.63804 3 575. 470. 410. 485. 83.5 330. 160. 255. 248. 85.23814 3 455. 390. 420. 422. 32.5 280. 160. 210. 217. 60.33817 3 625. 675. 555. 618. 60.3 220. 330. 265. 272. 55.33822 3 685. 675. 655. 672. 15.3 210. 195. 210. 205. 8.73839 3 615. 585. 380. 527. 127.9 150. 240. 255. 215. 56.8-----------------------------------------------------------------------------------------------------------------------------------MEAN 600.2 229.8S.D. 125.65 68.86 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3763 21.0 58. 45. 52. 9.23767 115.0 49. 44. 47. 3.53771 48.0 68. 70. 69. 1.43775 51.0 64. 73. 69. 6.43795 53.0 54. 52. 53. 1.43804 12.0 75. 88. 82. 9.23814 120.0 50. 41. 46. 6.43817 37.0 65. 63. 64. 1.43822 66.0 53. 62. 58. 6.43839 73.0 35. 39. 37. 2.8-----------------------------------------------------------------------------------------------------------------------------------MEAN 59.6 57.7S.D. 35.68 13.42 N 10 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3677 3 585. 565. 345. 498. 133.2 320. 240. 135. 232. 92.83686 3 760. 705. 470. 645. 154.0 395. 455. 185. 345. 141.83694 3 565. 390. 395. 450. 99.6 205. 230. 320. 252. 60.53696 3 630. 700. 745. 692. 58.0 360. 140. 375. 292. 131.63704 3 410. 350. 545. 435. 99.9 255. 250. 130. 212. 70.83714 3 580. 440. 455. 492. 76.9 720. 245. 370. 445. 246.23725 3 390. 565. 640. 532. 128.3 180. 355. 130. 222. 118.13738 3 540. 675. 655. 623. 72.9 155. 375. 310. 280. 113.03744 3 660. 415. 635. 570. 134.8 255. 305. 105. 222. 104.13757 3 720. 860. 750. 777. 73.7 335. 210. 205. 250. 73.7-----------------------------------------------------------------------------------------------------------------------------------MEAN 571.4 275.2S.D. 111.30 72.04 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3677 120.0 73. 76. 75. 2.13686 120.0 63. 63. 63. 0.03694 26.0 36. 38. 37. 1.43696 120.0 61. 71. 66. 7.13704 30.0 29. 24. 27. 3.53714 59.0 54. 32. 43. 15.63725 120.0 31. 35. 33. 2.83738 18.0 31. 30. 31. 0.73744 53.0 37. 34. 36. 2.13757 120.0 39. 41. 40. 1.4-----------------------------------------------------------------------------------------------------------------------------------MEAN 78.6 45.1S.D. 45.23 16.68 N 10 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3675 3 190. 435. 430. 352. 140.0 255. 185. 225. 222. 35.13695 3 730. 700. 630. 687. 51.3 120. 295. 205. 207. 87.53700 3 675. 760. 615. 683. 72.9 175. 235. 240. 217. 36.23702 3 465. 475. 595. 512. 72.3 215. 170. 170. 185. 26.03712 3 555. 635. 490. 560. 72.6 245. 190. 205. 213. 28.43713 3 885. 855. 750. 830. 70.9 145. 265. 265. 225. 69.33718 3 310. 430. 355. 365. 60.6 160. 210. 335. 235. 90.13720 3 400. 635. 345. 460. 154.0 165. 185. 270. 207. 55.83743 3 615. 820. 460. 632. 180.6 410. 260. 360. 343. 76.43747 3 535. 760. 755. 683. 128.5 65. 110. 275. 150. 110.6-----------------------------------------------------------------------------------------------------------------------------------MEAN 576.4 220.4S.D. 154.69 49.33 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3675 120.0 43. 38. 41. 3.53695 120.0 54. 64. 59. 7.13700 54.0 67. 56. 62. 7.83702 99.0 36. 30. 33. 4.23712 120.0 22. 21. 22. 0.73713 34.0 38. 43. 41. 3.53718 26.0 21. 25. 23. 2.83720 120.0 22. 20. 21. 1.43743 120.0 31. 25. 28. 4.23747 16.0 38. 31. 35. 4.9-----------------------------------------------------------------------------------------------------------------------------------MEAN 82.9 36.5S.D. 44.82 14.59 N 10 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3674 3 455. 335. 460. 417. 70.8 160. 235. 235. 210. 43.33701 3 610. 530. 520. 553. 49.3 120. 275. 75. 157. 104.93708 3 645. 655. 310. 537. 196.4 120. 145. 205. 157. 43.73711 3 585. 685. 835. 702. 125.8 385. 470. 350. 402. 61.73722 3 415. 470. 655. 513. 125.7 105. 455. 195. 252. 181.83726 3 420. 550. 525. 498. 69.0 90. 290. 285. 222. 114.13727 3 765. 720. 775. 753. 29.3 135. 155. 225. 172. 47.33731 3 535. 695. 685. 638. 89.6 180. 85. 180. 148. 54.83734 3 425. 640. 555. 540. 108.3 185. 160. 150. 165. 18.03756 3 805. 760. 855. 807. 47.5 175. 175. 240. 197. 37.5-----------------------------------------------------------------------------------------------------------------------------------MEAN 595.8 208.2S.D. 124.35 75.89 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3674 120.0 74. 72. 73. 1.43701 28.0 57. 62. 60. 3.53708 16.0 40. 39. 40. 0.73711 38.0 59. 60. 60. 0.73722 120.0 45. 49. 47. 2.83726 58.0 27. 27. 27. 0.03727 120.0 41. 45. 43. 2.83731 17.0 38. 31. 35. 4.93734 120.0 32. 31. 32. 0.73756 20.0 41. 37. 39. 2.8-----------------------------------------------------------------------------------------------------------------------------------MEAN 65.7 45.6S.D. 48.27 14.50 N 10 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3676 3 710. 775. 575. 687. 102.0 420. 210. 185. 272. 129.13678 3 515. 595. 695. 602. 90.2 395. 85. 245. 242. 155.03709 3 545. 505. 495. 515. 26.5 175. 320. 190. 228. 79.73716 3 490. 675. 790. 652. 151.4 70. 270. 270. 203. 115.53732 3 340. 725. 655. 573. 205.1 220. 135. 155. 170. 44.43739 3 975. 660. 415. 683. 280.7 110. 160. 200. 157. 45.13745 3 585. 500. 235. 440. 182.6 330. 150. 235. 238. 90.03746 3 595. 435. 865. 632. 217.3 100. 135. 325. 187. 121.13751 3 845. 875. 700. 807. 93.6 210. 145. 415. 257. 140.93754 3 725. 720. 635. 693. 50.6 160. 190. 235. 195. 37.7-----------------------------------------------------------------------------------------------------------------------------------MEAN 628.4 214.9S.D. 102.84 38.23 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3676 120.0 59. 61. 60. 1.43678 19.0 36. 44. 40. 5.73709 120.0 56. 68. 62. 8.53716 120.0 50. 51. 51. 0.73732 120.0 39. 41. 40. 1.43739 9.0 37. 28. 33. 6.43745 120.0 53. 43. 48. 7.13746 30.0 50. 37. 44. 9.23751 42.0 32. 35. 34. 2.13754 57.0 78. 73. 76. 3.5-----------------------------------------------------------------------------------------------------------------------------------MEAN 75.7 48.8S.D. 48.36 13.71 N 10 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3673 3 440. 720. 305. 488. 211.7 255. 435. 105. 265. 165.23679 3 610. 515. 440. 522. 85.2 275. 425. 280. 327. 85.23680 3 705. 400. 790. 632. 205.1 105. 295. 165. 188. 97.13685 3 650. 615. 540. 602. 56.2 155. 260. 200. 205. 52.73689 3 605. 595. 465. 555. 78.1 100. 160. 150. 137. 32.13698 3 565. 825. 640. 677. 133.8 70. 170. 510. 250. 230.73721 3 140. 755. 290. 395. 320.7 110. 680. 295. 362. 290.83730 3 665. 555. 615. 612. 55.1 365. 265. 255. 295. 60.83742 3 565. 550. 480. 532. 45.4 295. 105. 275. 225. 104.43753 3 635. 685. 435. 585. 132.3 100. 170. 105. 125. 39.1-----------------------------------------------------------------------------------------------------------------------------------MEAN 560.0 237.9S.D. 80.71 77.56 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A23 (NEUROMUSCULAR OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3673 9.0 39. 41. 40. 1.43679 17.0 43. 42. 43. 0.73680 102.0 54. 38. 46. 11.33685 16.0 44. 43. 44. 0.73689 120.0 37. 32. 35. 3.53698 18.0 46. 45. 46. 0.73721 21.0 34. 34. 34. 0.03730 74.0 47. 54. 51. 4.93742 23.0 27. 26. 27. 0.73753 32.0 50. 37. 44. 9.2-----------------------------------------------------------------------------------------------------------------------------------MEAN 43.2 41.0S.D. 40.22 7.10 N 10 10 PFOBv3.25 05/11/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
	
	


	
 


	   	 
  		  







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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION


	
  
	

	

 
 

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3774 3 835. 785. 560. 727. 146.5 615. 630. 430. 558. 111.43776 3 875. 1025. 740. 880. 142.6 265. 390. 325. 327. 62.53780 3 1245. 885. 1030. 1053. 181.1 345. 420. 445. 403. 52.03787 3 1070. 1195. 1035. 1100. 84.1 490. 740. 885. 705. 199.83803 3 420. 610. 565. 532. 99.3 465. 345. 335. 382. 72.33826 3 790. 895. 1045. 910. 128.2 375. 660. 400. 478. 157.83828 3 650. 565. 575. 597. 46.5 270. 335. 175. 260. 80.53832 3 955. 1205. 1065. 1075. 125.3 530. 575. 915. 673. 210.53837 3 725. 810. 750. 762. 43.7 650. 105. 435. 397. 274.53843 3 865. 940. 770. 858. 85.2 465. 425. 415. 435. 26.5-----------------------------------------------------------------------------------------------------------------------------------MEAN 849.4 461.8S.D. 196.33 144.11 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3774 2.0 65. 65. 65. 0.03776 38.0 98. 82. 90. 11.33780 6.0 64. 59. 62. 3.53787 120.0 87. 72. 80. 10.63803 35.0 48. 50. 49. 1.43826 16.0 82. 84. 83. 1.43828 120.0 103. 98. 101. 3.53832 13.0 86. 93. 90. 4.93837 89.0 70. 74. 72. 2.83843 19.0 50. 54. 52. 2.8-----------------------------------------------------------------------------------------------------------------------------------MEAN 45.8 74.4S.D. 46.24 17.30 N 10 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3769 3 915. 1045. 1180. 1047. 132.5 450. 590. 520. 520. 70.03772 3 1375. 865. 750. 997. 332.7 255. 345. 445. 348. 95.03773 3 980. 885. 885. 917. 54.8 1080. 835. 720. 878. 183.93781 3 935. 765. 630. 777. 152.8 265. 340. 390. 332. 62.93800 3 720. 595. 670. 662. 62.9 805. 180. 620. 535. 321.13805 3 670. 680. 945. 765. 156.0 100. 100. 530. 243. 248.33816 3 1230. 1125. 1295. 1217. 85.8 715. 695. 545. 652. 92.93818 3 915. 855. 900. 890. 31.2 195. 215. 170. 193. 22.53845 3 1330. 1370. 1175. 1292. 103.0 675. 635. 680. 663. 24.73846 3 1045. 740. 725. 837. 180.6 645. 725. 550. 640. 87.6-----------------------------------------------------------------------------------------------------------------------------------MEAN 940.1 500.4S.D. 200.96 217.41 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3769 120.0 72. 79. 76. 4.93772 29.0 75. 69. 72. 4.23773 53.0 89. 92. 91. 2.13781 20.0 67. 75. 71. 5.73800 120.0 107. 98. 103. 6.43805 34.0 63. 60. 62. 2.13816 11.0 93. 94. 94. 0.73818 120.0 40. 34. 37. 4.23845 3.0 63. 63. 63. 0.03846 65.0 92. 86. 89. 4.2-----------------------------------------------------------------------------------------------------------------------------------MEAN 57.5 75.8S.D. 46.78 19.36 N 10 10

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3762 3 695. 775. 770. 747. 44.8 200. 255. 165. 207. 45.43768 3 1070. 1045. 1305. 1140. 143.4 485. 615. 915. 672. 220.53786 3 1010. 760. 1065. 945. 162.6 875. 720. 730. 775. 86.73788 3 860. 850. 770. 827. 49.3 265. 620. 735. 540. 245.03813 3 830. 1140. 725. 898. 215.8 615. 685. 515. 605. 85.43819 3 530. 630. 550. 570. 52.9 605. 690. 805. 700. 100.43825 3 1010. 1020. 915. 982. 58.0 700. 330. 835. 622. 261.53833 3 715. 875. 700. 763. 97.0 475. 355. 440. 423. 61.73841 3 915. 830. 790. 845. 63.8 500. 310. 250. 353. 130.53842 3 680. 815. 720. 738. 69.3 315. 495. 430. 413. 91.2-----------------------------------------------------------------------------------------------------------------------------------MEAN 845.5 531.0S.D. 157.17 177.66 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3762 32.0 64. 60. 62. 2.83768 21.0 102. 87. 95. 10.63786 14.0 53. 58. 56. 3.53788 2.0 66. 65. 66. 0.73813 120.0 95. 102. 99. 4.93819 21.0 45. 40. 43. 3.53825 120.0 80. 84. 82. 2.83833 7.0 42. 42. 42. 0.03841 88.0 65. 76. 71. 7.83842 5.0 67. 61. 64. 4.2-----------------------------------------------------------------------------------------------------------------------------------MEAN 43.0 68.0S.D. 47.42 19.43 N 10 10

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3760 3 895. 1095. 1320. 1103. 212.6 655. 375. 405. 478. 153.73779 3 680. 1020. 700. 800. 190.8 335. 590. 140. 355. 225.73782 3 665. 685. 610. 653. 38.8 575. 705. 590. 623. 71.13784 3 965. 830. 900. 898. 67.5 270. 350. 575. 398. 158.13793 3 1030. 940. 685. 885. 179.0 525. 330. 410. 422. 98.03794 3 675. 860. 655. 730. 113.0 115. 205. 425. 248. 159.53820 3 1005. 785. 560. 783. 222.5 295. 425. 635. 452. 171.63821 3 800. 820. 750. 790. 36.1 175. 350. 300. 275. 90.13838 3 785. 845. 870. 833. 43.7 350. 325. 415. 363. 46.5-----------------------------------------------------------------------------------------------------------------------------------MEAN 830.6 401.6S.D. 126.60 112.42 N 9 9OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3760 120.0 83. 63. 73. 14.13779 120.0 101. 100. 101. 0.73782 117.0 103. 105. 104. 1.43784 120.0 75. 66. 71. 6.43793 120.0 69. 70. 70. 0.73794 120.0 86. 80. 83. 4.23820 120.0 62. 61. 62. 0.73821 3.0 72. 76. 74. 2.83838 9.0 67. 65. 66. 1.4-----------------------------------------------------------------------------------------------------------------------------------MEAN 94.3 78.2S.D. 50.11 14.93 N 9 9

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3763 3 730. 700. 735. 722. 18.9 215. 395. 135. 248. 133.23767 3 1470. 1295. 1115. 1293. 177.5 585. 510. 465. 520. 60.63771 3 750. 1040. 800. 863. 155.0 260. 430. 190. 293. 123.43775 3 1125. 995. 885. 1002. 120.1 575. 435. 790. 600. 178.83795 3 1025. 860. 805. 897. 114.5 575. 480. 455. 503. 63.33804 3 755. 780. 780. 772. 14.4 550. 320. 485. 452. 118.63814 3 385. 745. 795. 642. 223.7 400. 245. 155. 267. 123.93817 3 605. 960. 755. 773. 178.2 435. 420. 335. 397. 53.93822 3 980. 1195. 1245. 1140. 140.8 600. 620. 595. 605. 13.23839 3 615. 1000. 1080. 898. 248.6 495. 580. 590. 555. 52.2-----------------------------------------------------------------------------------------------------------------------------------MEAN 900.2 444.0S.D. 198.49 136.08 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3763 19.0 98. 90. 94. 5.73767 47.0 80. 72. 76. 5.73771 120.0 92. 80. 86. 8.53775 120.0 49. 46. 48. 2.13795 120.0 75. 74. 75. 0.73804 120.0 98. 82. 90. 11.33814 101.0 80. 88. 84. 5.73817 59.0 75. 50. 63. 17.73822 120.0 78. 71. 75. 4.93839 3.0 55. 60. 58. 3.5-----------------------------------------------------------------------------------------------------------------------------------MEAN 82.9 74.9S.D. 46.59 14.72 N 10 10

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3677 3 1145. 685. 775. 868. 243.8 440. 470. 445. 452. 16.13686 3 840. 605. 685. 710. 119.5 455. 455. 355. 422. 57.73694 3 745. 560. 530. 612. 116.4 410. 425. 575. 470. 91.23696 3 600. 990. 700. 763. 202.6 570. 370. 785. 575. 207.53704 3 1085. 1140. 1050. 1092. 45.4 485. 555. 625. 555. 70.03714 3 410. 650. 800. 620. 196.7 560. 535. 600. 565. 32.83725 3 665. 1015. 745. 808. 183.4 510. 395. 790. 565. 203.23738 3 540. 870. 895. 768. 198.1 180. 560. 540. 427. 213.93744 3 1110. 810. 1055. 992. 159.7 580. 600. 520. 567. 41.63757 3 320. 715. 750. 595. 238.8 365. 380. 180. 308. 111.4-----------------------------------------------------------------------------------------------------------------------------------MEAN 782.8 490.6S.D. 164.69 89.56 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3677 120.0 91. 87. 89. 2.83686 120.0 39. 56. 48. 12.03694 60.0 59. 57. 58. 1.43696 35.0 61. 62. 62. 0.73704 23.0 53. 47. 50. 4.23714 120.0 64. 59. 62. 3.53725 120.0 80. 72. 76. 5.73738 21.0 44. 57. 51. 9.23744 120.0 65. 73. 69. 5.73757 120.0 65. 54. 60. 7.8-----------------------------------------------------------------------------------------------------------------------------------MEAN 85.9 62.5S.D. 45.22 12.70 N 10 10

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3675 3 570. 695. 390. 552. 153.3 445. 295. 295. 345. 86.63695 3 905. 810. 710. 808. 97.5 405. 405. 460. 423. 31.83700 3 785. 765. 565. 705. 121.7 400. 145. 190. 245. 136.13702 3 430. 390. 420. 413. 20.8 290. 400. 390. 360. 60.83712 3 560. 515. 625. 567. 55.3 300. 345. 350. 332. 27.53713 3 785. 765. 700. 750. 44.4 325. 510. 592.-A 476. 136.83718 3 720. 590. 695. 668. 69.0 560. 455. 675. 563. 110.03720 3 910. 705. 820. 812. 102.8 705. 295. 665. 555. 226.13743 3 755. 580. 260. 532. 251.0 440. 180. 255. 292. 133.83747 3 675. 775. 720. 723. 50.1 105. 595. 145. 282. 272.1-----------------------------------------------------------------------------------------------------------------------------------MEAN 653.0 387.3S.D. 131.82 112.62 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISEA = OBVIOUS ERRONEOUS VALUE; GRIP STRENGTH APPARATUS RECORDS VALUES IN 5-GRAM INCREMENTS ONLY. VALUE INCLUDED IN CALCULATION OF MEAN.

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3675 120.0 45. 54. 50. 6.43695 120.0 88. 79. 84. 6.43700 120.0 83. 78. 81. 3.53702 34.0 50. 47. 49. 2.13712 120.0 27. 36. 32. 6.43713 120.0 81. 77. 79. 2.83718 120.0 69. 70. 70. 0.73720 120.0 73. 62. 68. 7.83743 120.0 42. 32. 37. 7.13747 24.0 82. 80. 81. 1.4-----------------------------------------------------------------------------------------------------------------------------------MEAN 101.8 63.1S.D. 38.44 19.50 N 10 10

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3674 3 1110. 1370. 930. 1137. 221.2 550. 630. 540. 573. 49.33701 3 585. 425. 685. 565. 131.1 285. 280. 190. 252. 53.53708 3 630. 515. 845. 663. 167.5 725. 510. 745. 660. 130.33711 3 905. 1130. 1190. 1075. 150.2 710. 400. 775. 628. 200.43722 3 625. 970. 750. 782. 174.7 120. 115. 220. 152. 59.23726 3 875. 710. 820. 802. 84.0 385. 205. 190. 260. 108.53727 3 1095. 525. 970. 863. 299.6 460. 660. 365. 495. 150.63731 3 535. 695. 615. 615. 80.0 200. 300. 685. 395. 256.13734 3 285. 175. 325. 262. 77.7 290. 235. 185. 237. 52.53756 3 830. 790. 420. 680. 226.1 395. 555. 360. 437. 104.0-----------------------------------------------------------------------------------------------------------------------------------MEAN 744.4 408.9S.D. 252.68 179.11 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3674 30.0 77. 69. 73. 5.73701 59.0 48. 31. 40. 12.03708 18.0 69. 65. 67. 2.83711 29.0 66. 65. 66. 0.73722 120.0 78. 80. 79. 1.43726 37.0 33. 30. 32. 2.13727 120.0 74. 81. 78. 4.93731 114.0 58. 54. 56. 2.83734 18.0 53. 54. 54. 0.73756 19.0 55. 54. 55. 0.7-----------------------------------------------------------------------------------------------------------------------------------MEAN 56.4 60.0S.D. 44.20 15.63 N 10 10

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3676 3 1100. 1085. 1085. 1090. 8.7 340. 440. 590. 457. 125.83678 3 810. 780. 615. 735. 105.0 620. 365. 630. 538. 150.23709 3 730. 495. 480. 568. 140.2 245. 550. 165. 320. 203.23716 3 855. 730. 675. 753. 92.2 190. 255. 605. 350. 223.23732 3 650. 820. 775. 748. 88.1 475. 410. 270. 385. 104.83739 3 670. 700. 650. 673. 25.2 450. 260. 245. 318. 114.33745 3 925. 965. 985. 958. 30.6 490. 530. 590. 537. 50.33746 3 820. 800. 815. 812. 10.4 340. 130. 445. 305. 160.43751 3 885. 805. 820. 837. 42.5 285. 215. 365. 288. 75.13754 3 1195. 845. 1095. 1045. 180.3 710. 785. 740. 745. 37.7-----------------------------------------------------------------------------------------------------------------------------------MEAN 821.9 424.3S.D. 164.96 145.91 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3676 21.0 74. 77. 76. 2.13678 28.0 83. 84. 84. 0.73709 120.0 85. 79. 82. 4.23716 120.0 56. 51. 54. 3.53732 120.0 66. 71. 69. 3.53739 26.0 56. 47. 52. 6.43745 43.0 36. 33. 35. 2.13746 23.0 69. 66. 68. 2.13751 120.0 42. 38. 40. 2.83754 28.0 89. 98. 94. 6.4-----------------------------------------------------------------------------------------------------------------------------------MEAN 64.9 65.4S.D. 47.78 19.58 N 10 10

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- HINDLIMB FORELIMB GRIP STRENGTH (grams) HINDLIMB GRIP STRENGTH (grams)ANIMAL EXTENSOR --------------------------------------- ---------------------------------------NUMBER STRENGTH 1 2 3 MEAN S.D. 1 2 3 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3673 3 650. 690. 435. 592. 137.1 540. 215. 370. 375. 162.63679 3 775. 595. 545. 638. 121.0 280. 580. 235. 365. 187.63680 3 815. 695. 930. 813. 117.5 260. 295. 470. 342. 112.53685 3 625. 500. 315. 480. 156.0 635. 590. 420. 548. 113.43689 3 625. 510. 450. 528. 88.9 295. 270. 420. 328. 80.43698 3 875. 845. 885. 868. 20.8 320. 475. 320. 372. 89.53721 3 570. 665. 775. 670. 102.6 170. 275. 145. 197. 69.03730 3 945. 895. 1005. 948. 55.1 365. 485. 420. 423. 60.13742 3 730. 540. 555. 608. 105.6 490. 460. 355. 435. 70.93753 3 910. 785. 855. 850. 62.6 400. 545. 490. 478. 73.2-----------------------------------------------------------------------------------------------------------------------------------MEAN 699.5 386.3S.D. 159.11 94.43 N 10 10OBSERVATION SCORE, UNLESS STATED OTHERWISE

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A24 (NEUROMUSCULAR OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATANEUROMUSCULAR OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- ROTAROD HINDLIMB FOOTSPLAY (mm)ANIMAL PERFORMANCE ----------------------------NUMBER (seconds) 1 2 MEAN S.D.-----------------------------------------------------------------------------------------------------------------------------------3673 49.0 49. 45. 47. 2.83679 120.0 72. 55. 64. 12.03680 120.0 69. 72. 71. 2.13685 25.0 62. 58. 60. 2.83689 120.0 65. 53. 59. 8.53698 4.0 61. 56. 59. 3.53721 15.0 49. 49. 49. 0.03730 120.0 66. 52. 59. 9.93742 10.0 53. 57. 55. 2.83753 33.0 62. 65. 64. 2.1-----------------------------------------------------------------------------------------------------------------------------------MEAN 61.6 58.7S.D. 51.76 7.10 N 10 10 PFOBv3.25 05/11/2009 R:06/10/2009

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A25 (PHYSIOLOGICAL OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3774 0.4 37.1 223.63776 0.6 37.6 236.03780 0.4 37.1 210.13787 0.3 38.2 264.83803 0.7 37.0 210.83826 0.3 36.2 231.73828 0.3 35.8 225.03832 0.4 37.2 287.23837 0.3 36.6 226.13843 0.3 36.8 227.3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 37.0 234.3S.D. 0.14 0.68 24.02 N 10 10 10

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A25 (PHYSIOLOGICAL OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3769 0.5 36.9 231.33772 0.4 37.0 229.23773 0.6 37.8 288.33781 0.3 37.2 244.53800 0.5 37.3 232.13805 0.3 35.3 220.73816 0.6 35.8 201.53818 0.6 37.2 217.73845 0.3 36.3 199.23846 0.3 38.1 269.5-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 36.9 233.4S.D. 0.13 0.86 28.01 N 10 10 10

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 TABLE A25 (PHYSIOLOGICAL OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3762 0.4 36.5 232.43768 0.3 37.1 242.43786 0.6 36.4 248.03788 0.5 37.6 217.03813 1.0 36.3 208.93819 0.3 36.1 247.93825 1.0 37.0 289.23833 0.6 37.6 208.03841 0.3 37.5 239.33842 1.0 36.2 233.4-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.6 36.8 236.6S.D. 0.30 0.60 23.72 N 10 10 10

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 TABLE A25 (PHYSIOLOGICAL OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3760 1.0 37.2 221.63770 0.4 37.8 192.13779 0.4 35.9 256.33782 0.6 37.0 265.83784 1.0 37.5 207.83793 0.4 37.7 261.03794 1.0 38.2 207.23820 0.3 36.2 232.03821 0.4 38.3 262.73838 0.6 37.5 233.4-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.6 37.3 234.0S.D. 0.28 0.79 26.62 N 10 10 10

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 TABLE A25 (PHYSIOLOGICAL OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3763 0.3 36.6 205.93767 0.3 38.1 228.43771 0.8 38.0 243.13775 0.4 38.4 249.43795 0.3 36.3 259.93804 0.4 35.7 220.33814 0.4 38.0 228.73817 0.4 37.4 266.73822 0.3 38.8 265.43839 0.5 37.6 209.3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 37.5 237.7S.D. 0.15 0.99 22.50 N 10 10 10

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 TABLE A25 (PHYSIOLOGICAL OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3677 0.5 39.0 200.73686 0.2 39.1 156.43694 0.3 38.2 174.83696 0.2 38.0 185.33704 0.4 38.3 161.93714 0.5 37.4 173.03725 0.3 39.1 153.03738 0.3 37.6 174.43744 0.4 39.1 157.33757 0.7 37.8 184.1-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 38.4 172.1S.D. 0.15 0.67 15.22 N 10 10 10

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 TABLE A25 (PHYSIOLOGICAL OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3675 0.4 38.5 158.53695 0.4 39.0 191.03700 0.2 37.8 174.23702 0.3 38.1 200.03712 0.3 38.8 181.03713 0.7 37.8 194.83718 0.5 37.6 166.93720 0.2 38.2 162.83743 0.4 37.1 191.23747 0.3 38.9 176.5-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 38.2 179.7S.D. 0.15 0.62 14.30 N 10 10 10

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 TABLE A25 (PHYSIOLOGICAL OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3674 0.3 38.5 160.63701 0.2 39.5 150.53708 0.3 36.3 183.93711 0.6 39.7 200.83722 0.3 38.3 179.23726 0.3 37.1 186.43727 0.4 38.6 198.83731 0.2 37.4 173.13734 0.4 38.0 154.03756 0.3 38.0 156.3-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.3 38.1 174.4S.D. 0.12 1.04 18.43 N 10 10 10

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 TABLE A25 (PHYSIOLOGICAL OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3676 0.4 37.6 208.83678 0.4 38.5 161.53709 0.3 38.0 187.13716 0.4 38.5 183.43732 0.3 38.6 153.93739 0.3 36.9 180.43745 0.4 38.8 164.63746 0.3 37.3 166.33751 0.3 36.8 186.13754 0.5 39.6 192.9-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 38.1 178.5S.D. 0.07 0.90 16.74 N 10 10 10

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 TABLE A25 (PHYSIOLOGICAL OBSERVATIONS - PRETEST - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: PRETEST----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3673 0.5 38.9 175.93679 0.4 38.5 170.53680 0.5 37.2 202.03685 0.3 39.0 180.03689 0.4 38.1 174.73698 0.3 38.9 161.73721 0.3 37.8 151.03730 0.3 37.8 194.53742 0.3 38.6 175.13753 0.3 39.3 182.6-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 38.4 176.8S.D. 0.08 0.66 14.66 N 10 10 10 PFOBv3.25 05/11/2009

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 TABLE A26 (PHYSIOLOGICAL OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3774 0.7 36.5 403.43776 0.3 39.0 329.43780 0.5 37.9 407.33787 0.3 38.8 410.43803 0.4 35.9 303.53826 0.4 37.2 324.53828 1.7 38.1 377.53832 0.3 38.0 445.43837 0.3 35.9 379.13843 0.6 36.5 404.7-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.6 37.4 378.5S.D. 0.43 1.14 45.44 N 10 10 10

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 TABLE A26 (PHYSIOLOGICAL OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3769 0.3 39.1 341.23772 0.3 36.4 392.03773 0.5 37.4 412.53781 0.5 37.5 371.53800 0.7 35.7 427.13805 0.3 36.4 367.43816 0.4 36.8 367.83818 0.3 37.5 402.53845 0.4 36.9 358.93846 0.7 36.9 412.1-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 37.1 385.3S.D. 0.16 0.91 27.90 N 10 10 10

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 TABLE A26 (PHYSIOLOGICAL OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3762 0.4 38.2 422.63768 0.6 36.3 402.43786 0.5 37.5 364.73788 0.3 36.4 377.13813 0.5 36.4 344.53819 0.4 36.4 412.83825 0.5 37.1 424.93833 0.3 36.9 369.03841 0.3 38.9 377.03842 7.9 37.9 410.5-----------------------------------------------------------------------------------------------------------------------------------MEAN 1.2 37.2 390.6S.D. 2.37 0.90 27.61 N 10 10 10

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 TABLE A26 (PHYSIOLOGICAL OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3760 0.3 37.6 347.33779 0.4 36.8 353.73782 0.3 37.0 407.63784 0.3 34.9 368.43793 0.3 39.1 356.33794 0.5 39.5 330.03820 0.5 39.7 393.63821 0.6 36.9 386.23838 0.3 37.4 400.8-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 37.7 371.5S.D. 0.12 1.54 26.77 N 9 9 9

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 TABLE A26 (PHYSIOLOGICAL OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: MALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3763 0.4 38.3 355.73767 0.6 38.0 413.43771 0.3 36.0 394.83775 0.2 37.8 339.73795 0.6 38.6 348.23804 0.5 37.2 326.43814 0.7 36.7 372.53817 0.4 36.8 395.33822 0.7 37.7 361.73839 0.3 37.6 368.6-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.5 37.5 367.6S.D. 0.18 0.80 27.20 N 10 10 10

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 TABLE A26 (PHYSIOLOGICAL OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 1 DOSE LEVEL: 0 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3677 0.3 39.6 269.93686 0.5 38.9 236.83694 0.3 39.6 245.33696 0.3 38.9 244.13704 0.3 37.3 222.83714 0.3 39.0 226.73725 0.7 38.8 236.03738 0.3 38.9 232.73744 0.6 38.2 237.83757 0.4 38.3 270.8-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 38.8 242.3S.D. 0.15 0.68 16.30 N 10 10 10

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 TABLE A26 (PHYSIOLOGICAL OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 2 DOSE LEVEL: 1000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3675 0.4 38.3 230.63695 0.4 39.1 255.23700 0.6 38.4 260.93702 0.3 37.3 264.23712 0.3 39.1 258.03713 0.3 39.3 259.03718 0.5 38.9 237.03720 0.2 39.0 252.03743 0.3 39.0 245.53747 1.0 38.6 313.4-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 38.7 257.6S.D. 0.23 0.59 22.38 N 10 10 10

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 TABLE A26 (PHYSIOLOGICAL OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 3 DOSE LEVEL: 1500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3674 0.5 37.7 246.33701 0.4 39.5 225.83708 0.3 38.0 253.53711 0.3 39.1 274.13722 0.3 37.2 260.03726 0.3 37.9 255.93727 0.3 39.6 265.03731 0.4 38.6 251.83734 0.3 38.4 219.83756 0.4 38.5 231.7-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 38.5 248.4S.D. 0.07 0.78 17.56 N 10 10 10

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 TABLE A26 (PHYSIOLOGICAL OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 4 DOSE LEVEL: 2000 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3676 0.4 39.4 279.83678 0.3 36.8 255.33709 0.3 39.2 269.53716 1.3 38.7 285.63732 0.5 38.4 235.73739 0.4 37.5 249.33745 0.3 37.6 257.13746 0.5 38.9 245.33751 0.3 38.3 272.03754 0.2 39.0 274.7-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.5 38.4 262.4S.D. 0.31 0.84 16.30 N 10 10 10

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 TABLE A26 (PHYSIOLOGICAL OBSERVATIONS - WEEK 3 - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY DATAPHYSIOLOGICAL OBSERVATIONS-------------------------- DOSE GROUP: 5 DOSE LEVEL: 2500 PPM SEX: FEMALESTEST PERIOD: WEEK 3----------------------------------------------------------------------------------------------------------------------------------- BODY BODYANIMAL CATALEPSY TEMPERATURE WEIGHTNUMBER (seconds) (degrees C) (grams)-----------------------------------------------------------------------------------------------------------------------------------3673 0.3 38.8 265.83679 0.3 39.0 248.73680 0.5 38.8 286.43685 0.4 39.3 231.53689 0.3 38.8 251.33698 0.4 38.3 268.73721 0.6 37.1 221.23730 0.5 39.5 265.13742 0.4 37.5 275.63753 0.3 39.4 237.7-----------------------------------------------------------------------------------------------------------------------------------MEAN 0.4 38.6 255.2S.D. 0.11 0.80 20.72 N 10 10 10 PFOBv3.25 05/11/2009

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 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL MOTOR ACTIVITY COUNTS MALE GROUP: 0 PPM TEST PERIOD: PRETEST 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3774 1476 445 975 275 603 88 36 0 18 0 121 0 3229 808 3776 1404 442 834 165 927 237 394 82 89 0 111 0 3759 926 3780 1405 457 363 22 53 2 18 1 35 0 36 0 1910 482 3787 1511 624 1033 305 913 298 546 201 342 121 65 0 4410 1549 3803 1173 389 397 53 30 0 122 0 74 0 141 3 1937 445 3826 1264 384 786 156 327 45 106 18 115 0 64 0 2662 603 3828 1292 343 1029 255 652 139 684 151 206 6 53 1 3916 895 3832 1309 392 1014 244 425 45 504 113 95 4 21 0 3368 798 3837 1168 380 1157 323 907 255 640 154 298 38 144 2 4314 1152 3843 1295 398 822 136 608 99 42 0 49 0 50 0 2866 633 MEAN 1330. 425. 841. 193. 545. 121. 309. 72. 132. 17. 81. 1. 3237. 829. S.D. 117.2 78.1 268.5 103.7 333.4 108.0 270.4 78.1 112.2 38.4 44.7 1.1 894.8 332.5 S.E. 37.0 24.7 84.9 32.8 105.4 34.2 85.5 24.7 35.5 12.1 14.1 0.3 283.0 105.2 N 10

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 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL MOTOR ACTIVITY COUNTS MALE GROUP: 1000 PPM TEST PERIOD: PRETEST 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3769 1319 421 1101 260 1091 286 701 118 5 0 1 0 4218 1085 3772 1199 432 563 146 169 0 203 0 364 0 620 174 3118 752 3773 1285 361 792 266 664 187 846 198 502 55 29 0 4118 1067 3781 1244 390 1209 411 802 213 741 201 912 318 252 67 5160 1600 3800 646 189 691 168 500 114 3 0 56 0 10 0 1906 471 3805 1369 339 433 70 639 143 173 5 250 80 22 0 2886 637 3816 912 314 225 2 345 65 4 0 17 1 248 0 1751 382 3818 957 216 326 49 215 45 5 0 57 1 148 0 1708 311 3845 1237 419 1061 385 450 73 193 4 38 1 15 0 2994 882 3846 1037 283 888 195 731 113 703 130 229 0 90 12 3678 733 MEAN 1121. 336. 729. 195. 561. 124. 357. 66. 243. 46. 144. 25. 3154. 792. S.D. 227.4 85.8 340.1 137.2 283.0 85.9 346.9 86.6 288.5 99.9 193.0 56.3 1158.3 387.9 S.E. 71.9 27.1 107.6 43.4 89.5 27.2 109.7 27.4 91.2 31.6 61.0 17.8 366.3 122.7 N 10

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 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL MOTOR ACTIVITY COUNTS MALE GROUP: 1500 PPM TEST PERIOD: PRETEST 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3762 1026 235 710 132 15 0 32 0 2 0 62 0 1847 367 3768 1146 313 784 130 630 134 624 120 412 6 278 64 3874 767 3786 1239 327 721 144 260 10 29 0 410 89 1058 242 3717 812 3788 881 175 418 114 12 0 37 0 17 0 26 0 1391 289 3813 1232 319 846 250 567 133 434 37 89 0 14 0 3182 739 3819 1410 448 930 233 656 177 542 101 716 132 37 0 4291 1091 3825 1291 363 1015 207 183 45 1 0 184 39 94 0 2768 654 3833 1239 375 775 181 812 172 341 5 5 0 59 10 3231 743 3841 814 190 507 95 582 139 43 1 41 1 17 0 2004 426 3842 894 195 255 58 12 0 70 0 230 0 297 48 1758 301 MEAN 1117. 294. 696. 154. 373. 81. 215. 26. 211. 27. 194. 36. 2806. 619. S.D. 201.5 91.5 236.0 61.9 308.7 76.3 243.6 46.0 236.6 46.9 320.8 75.9 1009.0 263.3 S.E. 63.7 28.9 74.6 19.6 97.6 24.1 77.0 14.5 74.8 14.8 101.5 24.0 319.1 83.2 N 10

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 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 INDIVIDUAL MOTOR ACTIVITY COUNTS MALE GROUP: 2000 PPM TEST PERIOD: PRETEST 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3760 730 153 66 0 100 7 565 86 302 6 26 0 1789 252 3770 1013 267 575 138 442 102 510 109 198 1 31 0 2769 617 3779 1474 422 961 230 631 114 818 188 266 27 10 0 4160 981 3782 902 258 746 171 391 95 638 102 446 81 122 0 3245 707 3784 585 148 710 169 235 48 79 0 12 0 49 1 1670 366 3793 1376 275 995 168 901 196 774 113 1015 209 660 77 5721 1038 3794 1339 362 733 195 611 122 1288 452 177 4 0 0 4148 1135 3820 1043 316 609 142 431 42 454 56 33 0 12 0 2582 556 3821 1243 396 518 103 226 1 22 0 5 0 100 2 2114 502 3838 993 296 288 38 114 4 74 1 490 87 841 194 2800 620 MEAN 1070. 289. 620. 135. 408. 73. 522. 111. 294. 42. 185. 27. 3100. 677. S.D. 288.3 91.4 283.5 70.6 253.9 63.6 395.1 134.4 304.8 67.8 303.6 63.3 1261.2 291.1 S.E. 91.2 28.9 89.6 22.3 80.3 20.1 124.9 42.5 96.4 21.4 96.0 20.0 398.8 92.1 N 10

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 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 INDIVIDUAL MOTOR ACTIVITY COUNTS MALE GROUP: 2500 PPM TEST PERIOD: PRETEST 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3763 1276 435 582 108 562 84 132 0 153 0 41 5 2746 632 3767 1291 434 767 174 537 64 501 68 79 0 47 3 3222 743 3771 1287 391 646 94 502 21 26 0 5 0 364 0 2830 506 3775 1668 558 1323 377 1123 323 573 96 598 198 135 12 5420 1564 3795 1617 602 1631 496 1142 343 1432 458 793 209 326 79 6941 2187 3804 1226 407 859 211 643 95 375 39 38 0 47 0 3188 752 3814 1495 554 452 116 314 3 174 3 10 0 73 0 2518 676 3817 1484 623 959 243 827 222 508 16 65 3 76 0 3919 1107 3822 1364 521 823 173 718 212 464 19 11 0 121 0 3501 925 3839 776 168 123 3 525 96 312 4 72 4 54 0 1862 275 MEAN 1348. 469. 817. 200. 689. 146. 450. 70. 182. 41. 128. 10. 3615. 937. S.D. 251.5 134.2 427.2 144.5 270.2 121.1 389.8 140.0 277.8 85.5 118.7 24.6 1505.9 561.9 S.E. 79.5 42.4 135.1 45.7 85.5 38.3 123.3 44.3 87.8 27.0 37.5 7.8 476.2 177.7 N 10

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 6 INDIVIDUAL MOTOR ACTIVITY COUNTS MALE GROUP: 0 PPM TEST PERIOD: WEEK 3 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3774 1598 342 828 151 482 85 5 0 84 0 51 0 3048 578 3776 1203 286 598 60 338 28 950 231 144 1 27 0 3260 606 3780 1522 402 811 145 441 39 581 126 238 5 70 0 3663 717 3787 1490 462 747 150 12 0 355 84 638 131 29 0 3271 827 3803 1339 275 723 151 336 45 109 3 523 115 538 91 3568 680 3826 1338 236 799 144 417 136 399 103 158 0 5 0 3116 619 3828 1124 252 833 192 784 181 694 177 232 51 3 0 3670 853 3832 1121 258 459 62 165 33 463 67 417 61 23 0 2648 481 3837 1313 328 1033 236 811 169 550 106 445 75 479 64 4631 978 3843 995 245 106 0 622 120 270 39 463 105 21 0 2477 509 MEAN 1304. 309. 694. 129. 441. 84. 438. 94. 334. 54. 125. 16. 3335. 685. S.D. 195.1 74.9 256.2 69.3 252.0 64.1 277.6 72.9 186.5 51.4 203.8 33.3 605.7 159.8 S.E. 61.7 23.7 81.0 21.9 79.7 20.3 87.8 23.1 59.0 16.3 64.4 10.5 191.5 50.5 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 7 INDIVIDUAL MOTOR ACTIVITY COUNTS MALE GROUP: 1000 PPM TEST PERIOD: WEEK 3 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3769 1257 249 921 164 757 165 650 105 509 117 1 0 4095 800 3772 1292 381 637 177 188 43 49 2 20 1 867 200 3053 804 3773 857 208 285 60 39 0 28 0 2 0 66 3 1277 271 3781 1234 304 792 154 660 127 456 92 381 69 88 23 3611 769 3800 1056 241 543 66 196 40 94 1 44 0 34 0 1967 348 3805 1308 275 302 44 511 110 567 99 40 0 52 0 2780 528 3816 1137 252 616 62 415 64 45 0 0 0 0 0 2213 378 3818 1202 227 460 75 204 31 520 104 486 107 12 0 2884 544 3845 1679 530 1078 288 810 216 804 222 222 36 72 0 4665 1292 3846 1091 249 117 25 348 66 162 17 308 69 145 0 2171 426 MEAN 1211. 292. 575. 112. 413. 86. 338. 64. 201. 40. 134. 23. 2872. 616. S.D. 212.6 96.7 299.6 82.0 265.0 67.2 292.5 73.4 206.5 47.2 261.5 62.7 1032.1 306.6 S.E. 67.2 30.6 94.8 25.9 83.8 21.3 92.5 23.2 65.3 14.9 82.7 19.8 326.4 97.0 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 8 INDIVIDUAL MOTOR ACTIVITY COUNTS MALE GROUP: 1500 PPM TEST PERIOD: WEEK 3 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3762 1156 180 721 74 261 36 233 27 186 10 48 0 2605 327 3768 1014 240 616 103 457 39 44 0 28 0 915 150 3074 532 3786 1120 217 834 114 760 95 807 197 19 0 614 145 4154 768 3788 931 161 262 35 367 49 80 0 23 0 292 48 1955 293 3813 1858 585 630 155 399 89 682 180 309 61 26 1 3904 1071 3819 978 249 496 83 584 92 635 98 502 7 596 80 3791 609 3825 1075 260 130 5 7 0 9 0 15 0 699 91 1935 356 3833 1735 450 1137 265 417 72 144 17 328 78 181 50 3942 932 3841 1181 260 519 96 302 27 449 102 114 27 160 49 2725 561 3842 726 88 440 62 132 0 24 0 4 0 21 0 1347 150 MEAN 1177. 269. 579. 99. 369. 50. 311. 62. 153. 18. 355. 61. 2943. 560. S.D. 352.7 144.9 285.3 71.6 214.3 36.0 305.5 77.2 173.6 28.5 323.8 55.5 990.3 294.6 S.E. 111.5 45.8 90.2 22.6 67.8 11.4 96.6 24.4 54.9 9.0 102.4 17.5 313.1 93.2 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 9 INDIVIDUAL MOTOR ACTIVITY COUNTS MALE GROUP: 2000 PPM TEST PERIOD: WEEK 3 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3760 531 126 465 80 192 3 279 67 210 53 79 4 1756 333 3779 1337 366 670 86 322 44 577 92 655 135 84 1 3645 724 3782 948 245 388 74 470 59 67 0 87 5 3 0 1963 383 3784 847 198 514 102 170 19 277 39 89 24 22 1 1919 383 3793 1301 193 781 93 150 10 598 107 262 34 763 227 3855 664 3794 847 140 342 22 458 82 285 36 104 14 2 0 2038 294 3820 972 241 644 98 490 66 423 25 34 0 18 0 2581 430 3821 1424 345 281 72 37 0 634 107 552 42 23 0 2951 566 3838 1759 395 614 110 332 36 58 0 25 0 22 0 2810 541 MEAN 1107. 250. 522. 82. 291. 35. 355. 53. 224. 34. 113. 26. 2613. 480. S.D. 375.3 98.1 167.4 25.8 162.4 29.5 217.6 42.5 229.7 42.2 245.6 75.4 769.0 150.8 S.E. 125.1 32.7 55.8 8.6 54.1 9.8 72.5 14.2 76.6 14.1 81.9 25.1 256.3 50.3 N 9

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 10 INDIVIDUAL MOTOR ACTIVITY COUNTS MALE GROUP: 2500 PPM TEST PERIOD: WEEK 3 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3763 1141 278 759 161 613 165 157 14 762 231 34 0 3466 849 3767 1811 510 632 75 433 68 122 0 61 0 2 0 3061 653 3771 1094 245 799 109 374 28 380 33 399 13 629 102 3675 530 3775 997 282 598 90 795 227 637 156 886 226 203 24 4116 1005 3795 1815 490 897 207 295 93 854 178 432 94 18 0 4311 1062 3804 1276 314 793 181 548 83 474 111 154 5 20 0 3265 694 3814 1405 421 309 47 36 0 355 11 109 0 94 0 2308 479 3817 1408 437 698 114 261 32 632 95 33 2 66 5 3098 685 3822 1867 575 865 155 851 142 588 141 433 90 511 105 5115 1208 3839 739 146 263 9 434 28 113 1 98 13 2 0 1649 197 MEAN 1355. 370. 661. 115. 464. 87. 431. 74. 337. 67. 158. 24. 3406. 736. S.D. 382.2 136.7 219.1 62.1 247.5 72.0 251.3 69.8 301.0 92.1 227.0 42.8 991.4 302.7 S.E. 120.9 43.2 69.3 19.6 78.3 22.8 79.5 22.1 95.2 29.1 71.8 13.5 313.5 95.7 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 11 INDIVIDUAL MOTOR ACTIVITY COUNTS FEMALE GROUP: 0 PPM TEST PERIOD: PRETEST 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3677 1324 469 974 277 784 248 904 303 600 219 1036 410 5622 1926 3686 1760 651 422 58 583 186 1233 419 104 0 20 0 4122 1314 3694 1912 684 747 133 25 0 172 53 535 123 246 39 3637 1032 3696 2102 705 1672 555 774 229 856 296 922 338 908 313 7234 2436 3704 1272 394 387 84 1146 362 320 44 54 0 55 0 3234 884 3714 1528 476 951 233 988 259 912 215 25 0 580 103 4984 1286 3725 1113 330 85 1 84 2 75 4 528 133 62 4 1947 474 3738 1850 655 785 262 93 17 50 1 115 0 667 175 3560 1110 3744 994 275 529 121 773 164 114 7 745 157 553 0 3708 724 3757 1444 564 763 172 289 84 1319 421 9 0 2 0 3826 1241 MEAN 1530. 520. 732. 190. 554. 155. 596. 176. 364. 97. 413. 104. 4187. 1243. S.D. 366.1 154.6 430.6 156.5 404.5 124.9 499.8 174.0 339.1 118.1 387.0 149.0 1451.6 572.4 S.E. 115.8 48.9 136.2 49.5 127.9 39.5 158.1 55.0 107.2 37.4 122.4 47.1 459.0 181.0 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 12 INDIVIDUAL MOTOR ACTIVITY COUNTS FEMALE GROUP: 1000 PPM TEST PERIOD: PRETEST 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3675 2033 711 1186 246 1292 332 503 68 8 0 27 0 5049 1357 3695 1449 541 887 338 689 159 553 133 29 0 820 271 4427 1442 3700 1530 511 700 151 11 0 647 113 49 0 137 19 3074 794 3702 1256 404 558 154 536 119 123 10 360 70 40 4 2873 761 3712 1343 422 965 219 87 2 12 0 93 8 871 216 3371 867 3713 1073 329 254 77 97 1 17 0 392 106 773 169 2606 682 3718 1285 430 889 222 609 217 0 0 18 0 731 217 3532 1086 3720 1614 596 604 125 433 150 734 163 901 296 370 138 4656 1468 3743 1109 371 778 193 546 111 719 161 678 116 780 185 4610 1137 3747 664 175 707 138 262 32 38 0 911 226 160 6 2742 577 MEAN 1336. 449. 753. 186. 456. 112. 335. 65. 344. 82. 471. 123. 3694. 1017. S.D. 364.4 149.5 254.7 74.0 378.9 108.8 321.6 71.2 367.3 105.8 355.5 105.1 907.8 327.0 S.E. 115.2 47.3 80.5 23.4 119.8 34.4 101.7 22.5 116.2 33.5 112.4 33.2 287.1 103.4 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 13 INDIVIDUAL MOTOR ACTIVITY COUNTS FEMALE GROUP: 1500 PPM TEST PERIOD: PRETEST 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3674 1453 502 105 0 291 87 299 39 89 0 38 0 2275 628 3701 1653 604 673 167 67 0 5 0 194 50 1019 340 3611 1161 3708 1267 495 600 173 658 217 942 277 763 181 744 199 4974 1542 3711 1720 628 794 198 1279 479 1462 571 1188 395 743 289 7186 2560 3722 1137 447 365 100 21 0 68 2 220 6 1017 361 2828 916 3726 1591 427 1258 317 386 80 775 159 184 20 1089 272 5283 1275 3727 1510 515 832 248 694 273 861 264 33 0 3 0 3933 1300 3731 1393 378 779 171 782 197 504 127 16 0 35 0 3509 873 3734 1657 716 877 311 914 316 487 85 362 81 179 53 4476 1562 3756 1389 380 664 162 85 0 371 83 553 192 19 0 3081 817 MEAN 1477. 509. 695. 185. 518. 165. 577. 161. 360. 93. 489. 151. 4116. 1263. S.D. 186.1 110.9 307.9 94.3 416.7 160.5 441.7 173.6 374.5 128.9 472.8 155.1 1431.0 551.4 S.E. 58.8 35.1 97.4 29.8 131.8 50.7 139.7 54.9 118.4 40.8 149.5 49.1 452.5 174.4 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 14 INDIVIDUAL MOTOR ACTIVITY COUNTS FEMALE GROUP: 2000 PPM TEST PERIOD: PRETEST 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3676 1540 521 1634 608 204 7 48 0 375 114 1660 558 5461 1808 3678 1187 441 498 171 1 0 18 0 206 50 11 0 1921 662 3709 1149 364 550 123 669 120 334 75 4 0 187 43 2893 725 3716 1330 457 934 303 749 169 185 3 7 0 107 1 3312 933 3732 1373 389 665 98 801 151 69 2 386 0 606 101 3900 741 3739 918 247 61 4 31 0 139 0 575 146 620 172 2344 569 3745 1436 556 926 218 351 36 197 55 87 0 3 1 3000 866 3746 1471 468 505 58 796 246 101 16 114 0 594 169 3581 957 3751 1525 497 1248 351 623 169 788 241 48 0 34 0 4266 1258 3754 831 279 395 51 106 0 967 324 565 158 159 0 3023 812 MEAN 1276. 422. 742. 199. 433. 90. 285. 72. 237. 47. 398. 105. 3370. 933. S.D. 249.0 101.4 455.2 182.0 328.8 91.6 327.9 115.8 222.3 66.6 510.8 174.0 1007.8 361.6 S.E. 78.7 32.1 144.0 57.6 104.0 29.0 103.7 36.6 70.3 21.0 161.5 55.0 318.7 114.4 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 15 INDIVIDUAL MOTOR ACTIVITY COUNTS FEMALE GROUP: 2500 PPM TEST PERIOD: PRETEST 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3673 1539 568 1406 493 325 33 51 2 28 0 290 67 3639 1163 3679 1639 569 887 276 386 64 231 41 93 3 74 1 3310 954 3680 1388 394 889 261 187 14 735 188 84 7 57 0 3340 864 3685 1654 606 789 232 1008 311 59 5 39 2 108 1 3657 1157 3689 1433 439 259 41 929 157 796 177 23 2 376 78 3816 894 3698 898 284 175 2 10 1 40 0 389 48 791 169 2303 504 3721 2001 643 1290 370 528 158 37 0 79 2 148 5 4083 1178 3730 1560 530 900 280 40 1 206 13 807 200 20 0 3533 1024 3742 1331 414 1013 161 628 75 829 200 392 39 86 0 4279 889 3753 1089 287 871 207 334 69 332 75 163 0 951 252 3740 890 MEAN 1453. 473. 848. 232. 438. 88. 332. 70. 210. 30. 290. 57. 3570. 952. S.D. 308.1 128.8 386.4 144.3 340.1 96.7 329.4 85.0 251.2 62.1 327.3 88.1 536.9 200.7 S.E. 97.4 40.7 122.2 45.6 107.6 30.6 104.2 26.9 79.4 19.6 103.5 27.9 169.8 63.5 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 16 INDIVIDUAL MOTOR ACTIVITY COUNTS FEMALE GROUP: 0 PPM TEST PERIOD: WEEK 3 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3677 1114 317 548 145 122 22 238 47 499 110 255 32 2776 673 3686 1387 524 89 5 534 110 194 26 213 5 10 0 2427 670 3694 1538 439 619 144 486 74 44 1 10 0 21 0 2718 658 3696 1531 443 657 187 144 23 177 57 25 0 555 167 3089 877 3704 1299 415 778 196 860 286 189 16 319 70 999 263 4444 1246 3714 1332 430 995 254 1148 418 978 328 858 337 628 196 5939 1963 3725 1511 479 491 103 212 31 586 201 544 104 570 182 3914 1100 3738 986 169 126 5 32 0 675 136 181 19 92 0 2092 329 3744 1096 300 463 110 33 0 119 0 10 0 101 32 1822 442 3757 1675 477 1087 268 804 179 676 203 1004 224 393 73 5639 1424 MEAN 1347. 399. 585. 142. 438. 114. 388. 102. 366. 87. 362. 95. 3486. 938. S.D. 225.2 106.6 324.1 90.3 393.5 140.4 314.0 111.1 354.0 113.7 325.0 98.1 1446.8 499.9 S.E. 71.2 33.7 102.5 28.6 124.4 44.4 99.3 35.1 112.0 36.0 102.8 31.0 457.5 158.1 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 17 INDIVIDUAL MOTOR ACTIVITY COUNTS FEMALE GROUP: 1000 PPM TEST PERIOD: WEEK 3 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3675 1998 670 1564 440 885 251 6 0 30 1 19 0 4502 1362 3695 1222 308 494 99 59 1 818 185 1057 243 39 1 3689 837 3700 1496 451 636 114 593 89 546 141 53 0 6 0 3330 795 3702 1702 632 1229 371 773 195 966 234 762 254 1151 379 6583 2065 3712 1418 401 719 113 16 0 766 206 482 110 5 0 3406 830 3713 843 196 129 0 261 20 205 36 472 87 158 33 2068 372 3718 1621 414 781 216 585 131 27 0 723 186 424 68 4161 1015 3720 1416 453 968 228 666 163 346 115 596 206 333 121 4325 1286 3743 1481 433 987 292 844 198 347 67 118 33 40 0 3817 1023 3747 1125 263 488 69 849 223 399 90 222 62 34 0 3117 707 MEAN 1432. 422. 800. 194. 553. 127. 443. 107. 452. 118. 221. 60. 3900. 1029. S.D. 319.9 148.1 409.1 140.8 327.3 94.6 328.3 83.7 343.1 97.5 358.6 119.1 1173.8 461.5 S.E. 101.2 46.8 129.4 44.5 103.5 29.9 103.8 26.5 108.5 30.8 113.4 37.7 371.2 145.9 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 18 INDIVIDUAL MOTOR ACTIVITY COUNTS FEMALE GROUP: 1500 PPM TEST PERIOD: WEEK 3 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3674 1773 582 1292 431 1435 467 1580 533 1374 531 1900 732 9354 3276 3701 1471 362 1070 365 706 244 244 47 691 150 70 0 4252 1168 3708 980 257 634 151 385 114 214 41 47 0 213 32 2473 595 3711 1610 471 1054 253 373 81 744 154 534 75 786 199 5101 1233 3722 1456 510 255 57 286 62 391 27 126 3 23 1 2537 660 3726 1589 431 765 158 741 119 959 225 443 90 219 41 4716 1064 3727 1186 293 397 34 452 100 151 2 21 0 561 99 2768 528 3731 1636 404 1111 239 778 155 151 11 90 0 68 0 3834 809 3734 1335 433 909 287 691 195 533 165 419 139 791 259 4678 1478 3756 1084 209 579 148 183 28 25 0 282 69 20 0 2173 454 MEAN 1412. 395. 807. 212. 603. 157. 499. 121. 403. 106. 465. 136. 4189. 1127. S.D. 259.8 116.4 337.4 127.3 359.1 126.1 479.1 165.1 409.2 160.1 587.7 228.3 2105.9 828.1 S.E. 82.2 36.8 106.7 40.3 113.5 39.9 151.5 52.2 129.4 50.6 185.9 72.2 665.9 261.9 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 19 INDIVIDUAL MOTOR ACTIVITY COUNTS FEMALE GROUP: 2000 PPM TEST PERIOD: WEEK 3 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3676 1867 641 997 354 373 127 662 163 60 0 341 94 4300 1379 3678 1491 409 518 87 539 75 95 0 683 197 766 129 4092 897 3709 847 222 714 114 102 3 217 33 56 1 85 0 2021 373 3716 1237 351 508 145 158 21 2 0 82 0 105 1 2092 518 3732 1683 481 1321 293 298 26 581 153 65 1 83 2 4031 956 3739 1156 241 684 99 275 34 358 71 482 161 167 5 3122 611 3745 1597 501 1038 212 183 21 221 33 8 0 142 27 3189 794 3746 1246 411 757 256 975 379 682 271 253 92 272 85 4185 1494 3751 1454 458 197 23 59 2 40 6 44 0 8 0 1802 489 3754 981 233 668 90 39 0 62 0 331 69 534 150 2615 542 MEAN 1356. 395. 740. 167. 300. 69. 292. 73. 206. 52. 250. 49. 3145. 805. S.D. 319.7 135.6 316.2 106.3 282.4 115.8 263.9 92.7 227.6 75.1 237.8 59.3 975.1 381.7 S.E. 101.1 42.9 100.0 33.6 89.3 36.6 83.5 29.3 72.0 23.8 75.2 18.8 308.3 120.7 N 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A27 (PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 20 INDIVIDUAL MOTOR ACTIVITY COUNTS FEMALE GROUP: 2500 PPM TEST PERIOD: WEEK 3 0 TO 10 MINS 11 TO 20 MINS 21 TO 30 MINS 31 TO 40 MINS 41 TO 50 MINS 51 TO 60 MINS COMBINED ANIMAL TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB TOTAL AMB----------------------------------------------------------------------------------------------------------------------------------- 3673 1333 373 588 109 861 244 474 117 667 169 80 1 4003 1013 3679 2152 669 473 65 316 69 10 0 132 1 409 144 3492 948 3680 1129 279 335 43 499 41 630 67 363 66 485 76 3441 572 3685 1118 312 48 0 336 73 5 0 65 12 12 0 1584 397 3689 969 231 575 86 266 64 75 0 70 1 907 203 2862 585 3698 1093 279 539 74 469 62 42 0 169 2 519 103 2831 520 3721 1460 328 722 169 1068 273 400 84 114 0 1265 409 5029 1263 3730 1491 413 354 64 497 87 185 55 20 0 540 147 3087 766 3742 1577 459 644 121 757 95 388 4 371 49 17 0 3754 728 3753 1185 345 331 47 405 80 598 77 34 0 5 0 2558 549 MEAN 1351. 369. 461. 78. 547. 109. 281. 40. 201. 30. 424. 108. 3264. 734. S.D. 344.5 125.1 197.7 46.9 262.9 80.6 245.8 44.6 206.0 54.2 421.1 129.1 924.1 268.0 S.E. 108.9 39.6 62.5 14.8 83.1 25.5 77.7 14.1 65.1 17.1 133.2 40.8 292.2 84.8 N 10 PKMASUv1.07 05/11/2009

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A28 (UNSCHEDULED DEATHS - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL MACROSCOPIC FINDINGSANIMAL NO. 3770 GROUP 4: 2000 PPM MALE FOUND DEAD 03/19/09 DATE OF DEATH: 03/19/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- STOMACH GROSS: AREA(S), DARK RED P FEW, IRREGULARLY SHAPED, GLANDULAR PORTION NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM EPIDIDYMIDES ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS NERVE, SCIATIC PANCREAS PHARYNX PITUITARY PROSTATE RECTUM SPINAL CORD SAL. GLAND MAND SKELETAL MUSCLE SKIN SPLEEN SEMINAL VESICLES TESTES PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A28 (UNSCHEDULED DEATHS - PHASE II)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL MACROSCOPIC FINDINGSANIMAL NO. 3742 GROUP 5: 2500 PPM FEMALE EUTH IN EXTREMIS 03/22/09 DATE OF DEATH: 03/22/09 GRADE----------------------------------------------------------------------------------------------------------------------------------- NO SIGNIFICANT CHANGES OBSERVED GROSS:ADRENAL GLANDS AORTA STERNEBRAE FEMUR JOINT BRAIN CECUM COLON DUODENUM ESOPHAGUS EYES NERVES, OPTIC HEART HARDERIAN GLANDS ILEUM JEJUNUM KIDNEYS LN, MANDIBULAR LAC. GLAND EXOR LIVER LN, MESENTERIC LUNGS MAMMARY GLAND NERVE, SCIATIC OVIDUCTS OVARIES PANCREAS PHARYNX PITUITARY RECTUM SPINAL CORD SAL. GLAND MAND STOMACH SKELETAL MUSCLE SKIN SPLEEN PEYER'S PATCHES THYROID GLANDS THYMUS TRACHEA URINARY BLADDER UTERUS VAGINA CERVIX LARYNX LN, AXILLARY LN, MEDIASTINAL LN, BRONCHIAL NASAL CAVITY GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT PGRHv4.63 05/11/2009 R:06/10/2009

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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 1 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3774 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.90 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 20.5 EYE, RIGHT; OPTIC NERVE, RIGHTBRAIN WIDTH(MM) 14.5 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 2 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3776 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.14 NO SIGNIFICANTBRAIN LENGTH(MM) 21.4 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.7 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 3 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3780 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.93 NO SIGNIFICANTBRAIN LENGTH(MM) 20.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 14.8 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 4 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3787 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.19 NO SIGNIFICANTBRAIN LENGTH(MM) 21.7 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.2 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 5 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3803 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.03 NO SIGNIFICANTBRAIN LENGTH(MM) 20.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.1 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 6 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3826 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.08 NO SIGNIFICANTBRAIN LENGTH(MM) 21.1 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.7 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 7 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3828 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.04 GENERAL COMMENT MICRO: ALL BRAIN SECTIONS WERE ANTERIOR TO STANDARD LEVELS PBRAIN LENGTH(MM) 21.1 ALL PROTOCOL-MANDATED BRAIN REGIONS WERE PRESENTBRAIN WIDTH(MM) 15.1 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 8 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3832 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.21 NO SIGNIFICANTBRAIN LENGTH(MM) 21.1 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.7 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 9 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3837 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.34 NO SIGNIFICANTBRAIN LENGTH(MM) 22.0 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.9 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 10 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3843 GROUP 1: 0 PPM MALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.23 LUMBAR VENT. FIB MICRO: DEGENERATION, AXONAL 1BRAIN LENGTH(MM) 21.7 FOCALBRAIN WIDTH(MM) 15.7 OPTIC NERVE MICRO: NO SIGNIFICANT CHANGES OBSERVED ONE OPTIC NERVE NOT WELL REPRESENTED IN THE SECTION (SLIDE 8) NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 11 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3769 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.06 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.5 BRAINBRAIN WIDTH(MM) 15.3 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 12 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3772 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.26 NO SIGNIFICANTBRAIN LENGTH(MM) 22.4 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.1 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 13 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3773 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.22 NO SIGNIFICANTBRAIN LENGTH(MM) 21.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.8 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 14 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3781 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.14 NO SIGNIFICANTBRAIN LENGTH(MM) 20.8 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.6 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 15 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3800 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.20 NO SIGNIFICANTBRAIN LENGTH(MM) 21.1 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.7 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 16 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3805 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.98 NO SIGNIFICANTBRAIN LENGTH(MM) 21.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.8 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 17 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3816 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.23 NO SIGNIFICANTBRAIN LENGTH(MM) 21.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.5 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 18 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3818 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.18 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 22.0 BRAINBRAIN WIDTH(MM) 15.4 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 19 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3845 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.16 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.5 BRAINBRAIN WIDTH(MM) 15.2 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 20 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3846 GROUP 2: 1000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.27 NO SIGNIFICANTBRAIN LENGTH(MM) 21.4 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.5 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 21 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3762 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.27 NO SIGNIFICANTBRAIN LENGTH(MM) 22.1 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.3 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 22 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3768 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.17 NO SIGNIFICANTBRAIN LENGTH(MM) 21.5 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.4 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 23 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3786 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.21 NO SIGNIFICANTBRAIN LENGTH(MM) 21.5 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.5 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 24 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3788 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.16 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.1 BRAINBRAIN WIDTH(MM) 14.7 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 25 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3813 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.14 NO SIGNIFICANTBRAIN LENGTH(MM) 21.2 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.5 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 26 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3819 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.11 NO SIGNIFICANTBRAIN LENGTH(MM) 21.2 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.6 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 27 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3825 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.25 NO SIGNIFICANTBRAIN LENGTH(MM) 22.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.5 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 28 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3833 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.01 NO SIGNIFICANTBRAIN LENGTH(MM) 20.5 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.6 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 29 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3841 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.08 NO SIGNIFICANTBRAIN LENGTH(MM) 21.5 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.7 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 30 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3842 GROUP 3: 1500 PPM MALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.06 NO SIGNIFICANTBRAIN LENGTH(MM) 21.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.4 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 31 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3760 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.26 NO SIGNIFICANTBRAIN LENGTH(MM) 21.7 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.9 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 32 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3779 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.09 NO SIGNIFICANTBRAIN LENGTH(MM) 20.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.8 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 33 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3782 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.99 NO SIGNIFICANTBRAIN LENGTH(MM) 21.0 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.6 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 34 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3784 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.26 NO SIGNIFICANTBRAIN LENGTH(MM) 21.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.3 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 35 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3793 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.94 NO SIGNIFICANTBRAIN LENGTH(MM) 21.4 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.1 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 36 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3794 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.19 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.6 BRAINBRAIN WIDTH(MM) 15.2 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 37 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3820 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.07 NO SIGNIFICANTBRAIN LENGTH(MM) 21.5 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.9 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 38 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3821 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.10 NO SIGNIFICANTBRAIN LENGTH(MM) 21.5 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.4 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 39 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3838 GROUP 4: 2000 PPM MALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.20 NO SIGNIFICANTBRAIN LENGTH(MM) 21.9 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.9 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 40 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3763 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.09 NO SIGNIFICANTBRAIN LENGTH(MM) 21.5 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.0 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 41 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3767 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.23 NO SIGNIFICANTBRAIN LENGTH(MM) 21.9 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.7 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 42 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3771 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.14 NO SIGNIFICANTBRAIN LENGTH(MM) 21.6 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.8 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 43 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3775 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.20 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.1 BRAINBRAIN WIDTH(MM) 15.5 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 44 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3795 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.37 NO SIGNIFICANTBRAIN LENGTH(MM) 22.6 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 16.1 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 45 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3804 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.89 NO SIGNIFICANTBRAIN LENGTH(MM) 21.1 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.4 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 46 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3814 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.05 NO SIGNIFICANTBRAIN LENGTH(MM) 21.0 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.4 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 47 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3817 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.13 NO SIGNIFICANTBRAIN LENGTH(MM) 20.9 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.6 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 48 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3822 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.11 NO SIGNIFICANTBRAIN LENGTH(MM) 21.7 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.4 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 49 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3839 GROUP 5: 2500 PPM MALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.99 NO SIGNIFICANTBRAIN LENGTH(MM) 21.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 14.8 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 50 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3677 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.07 NO SIGNIFICANTBRAIN LENGTH(MM) 20.7 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.4 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 51 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3686 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.79 BRAIN AREA(S), DEPRESSED PBRAIN LENGTH(MM) 20.3 ONE, 4 X 1 X LESS THAN 1 MM, CEREBRAL HEMISPHERE, LEFTBRAIN WIDTH(MM) 15.0 NO SIGNIFICANT CHANGES OBSERVED GROSS:SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 52 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3694 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.08 NO SIGNIFICANTBRAIN LENGTH(MM) 21.1 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.6 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 53 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3696 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.13 NO SIGNIFICANTBRAIN LENGTH(MM) 21.6 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.4 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 54 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3704 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.91 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 19.2 BRAINBRAIN WIDTH(MM) 15.1 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 55 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3714 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.07 NO SIGNIFICANTBRAIN LENGTH(MM) 21.7 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.2 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 56 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3725 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.99 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.1 BRAINBRAIN WIDTH(MM) 15.2 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 57 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3738 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.88 EYES MICRO: DYSPLASIA, RETINAL 1BRAIN LENGTH(MM) 20.4 FOCAL DISORGANIZATION OF INNER/OUTER NUCLEAR LAYERS AND LOSSBRAIN WIDTH(MM) 15.0 OF RODS/CONES NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 58 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3744 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.96 LUMBAR VENT. FIB MICRO: DEGENERATION, AXONAL 1BRAIN LENGTH(MM) 20.5 FOCALBRAIN WIDTH(MM) 15.2 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 59 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3757 GROUP 1: 0 PPM FEMALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.16 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.3 BRAINBRAIN WIDTH(MM) 15.3 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 60 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3675 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.90 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 20.3 BRAINBRAIN WIDTH(MM) 15.0 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 61 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3695 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.21 NO SIGNIFICANTBRAIN LENGTH(MM) 21.7 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.5 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 62 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3700 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.10 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.3 TRIGEMINAL NERVE, LEFTBRAIN WIDTH(MM) 15.1 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 63 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3702 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.97 NO SIGNIFICANTBRAIN LENGTH(MM) 20.5 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.0 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 64 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3712 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.98 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.3 BRAINBRAIN WIDTH(MM) 15.2 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 65 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3713 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.03 NO SIGNIFICANTBRAIN LENGTH(MM) 21.1 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.6 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 66 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3718 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.02 NO SIGNIFICANTBRAIN LENGTH(MM) 21.7 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.3 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 67 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3720 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.07 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.3 BRAINBRAIN WIDTH(MM) 15.4 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 68 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3743 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.93 NO SIGNIFICANTBRAIN LENGTH(MM) 20.2 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.2 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 69 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3747 GROUP 2: 1000 PPM FEMALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.09 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.3 BRAINBRAIN WIDTH(MM) 15.3 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 70 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3674 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.15 NO SIGNIFICANTBRAIN LENGTH(MM) 21.5 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 14.9 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 71 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3701 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.82 NO SIGNIFICANTBRAIN LENGTH(MM) 20.2 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 14.5 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 72 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3708 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.14 NO SIGNIFICANTBRAIN LENGTH(MM) 21.4 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.6 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 73 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3711 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.11 NO SIGNIFICANTBRAIN LENGTH(MM) 21.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.4 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 74 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3722 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.08 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.2 BRAINBRAIN WIDTH(MM) 15.1 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 75 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3726 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.06 NO SIGNIFICANTBRAIN LENGTH(MM) 21.0 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.7 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 76 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3727 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.03 NO SIGNIFICANTBRAIN LENGTH(MM) 21.0 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.4 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 77 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3731 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.98 NO SIGNIFICANTBRAIN LENGTH(MM) 20.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.3 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 78 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3734 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.86 NO SIGNIFICANTBRAIN LENGTH(MM) 19.6 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 14.9 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 79 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3756 GROUP 3: 1500 PPM FEMALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.97 NO SIGNIFICANTBRAIN LENGTH(MM) 21.3 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.0 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 80 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3676 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.12 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.2 BRAINBRAIN WIDTH(MM) 15.4 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 81 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3678 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.00 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.5 BRAINBRAIN WIDTH(MM) 15.0 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 82 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3709 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.12 NO SIGNIFICANTBRAIN LENGTH(MM) 21.0 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.7 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 83 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3716 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.07 NO SIGNIFICANTBRAIN LENGTH(MM) 21.2 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.6 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 84 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3732 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.04 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 20.1 BRAINBRAIN WIDTH(MM) 15.1 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 85 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3739 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.12 NO SIGNIFICANTBRAIN LENGTH(MM) 21.4 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.4 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 86 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3745 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.09 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 20.7 BRAINBRAIN WIDTH(MM) 15.0 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 87 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3746 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.09 NO SIGNIFICANTBRAIN LENGTH(MM) 21.2 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.5 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 88 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3751 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.04 GENERAL COMMENT ORGAN DAMAGED AT TRIMMING PBRAIN LENGTH(MM) 21.6 BRAINBRAIN WIDTH(MM) 15.4 NO SIGNIFICANT CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB. GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 89 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3754 GROUP 4: 2000 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.11 NO SIGNIFICANTBRAIN LENGTH(MM) 21.1 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.1 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 90 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3673 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.05 NO SIGNIFICANTBRAIN LENGTH(MM) 21.0 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.6 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 91 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3679 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.11 NO SIGNIFICANTBRAIN LENGTH(MM) 21.7 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.5 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 92 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3680 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.15 NO SIGNIFICANTBRAIN LENGTH(MM) 21.4 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.6 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 93 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3685 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 1.86 NO SIGNIFICANTBRAIN LENGTH(MM) 20.6 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 14.7 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 94 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3689 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/24/09 DATE OF DEATH: 03/24/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.02 NO SIGNIFICANTBRAIN LENGTH(MM) 20.8 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.2 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 95 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3698 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/23/09 DATE OF DEATH: 03/23/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.25 NO SIGNIFICANTBRAIN LENGTH(MM) 21.6 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.8 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 96 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3721 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/25/09 DATE OF DEATH: 03/25/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.02 NO SIGNIFICANTBRAIN LENGTH(MM) 21.2 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.1 MICRO:SPINAL C.-CERV. SPINAL C.-LUMB. HIPPOCAMPUS OLFACTORY BULBS TRIG. GANGLION TRIGEMINAL NERVE LUMBAR DOR. GANG LUMBAR DOR. FIB. LUMBAR VENT. FIB CERV. DOR. GANG. CERV. DOR. FIB. CERV. VENT. FIB. SCIATIC NERVE SURAL NERVE TIBIAL NERVE PERONEAL NERVE MIDBRAIN CEREBELLUM OPTIC NERVE CEREBRAL CORTEX EYES BASAL GANGLIA THALAMUS HYPOTHALAMUS PONS MEDULLA OBLONG. GASTROC. MUSCLE GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 97 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3730 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/26/09 DATE OF DEATH: 03/26/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.01 NO SIGNIFICANTBRAIN LENGTH(MM) 21.0 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.6 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A29 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 98 INDIVIDUAL MACROSCOPIC AND MICROSCOPIC FINDINGSANIMAL NO. 3753 GROUP 5: 2500 PPM FEMALE SCHEDULED EUTH 03/27/09 DATE OF DEATH: 03/27/09 GRADE-----------------------------------------------------------------------------------------------------------------------------------ORGAN WEIGHT ABS.(G) PERFUSEDBRAIN 2.06 NO SIGNIFICANTBRAIN LENGTH(MM) 21.0 CHANGES OBSERVED GROSS:BRAIN SPINAL C.-CERV. SPINAL C.-LUMB.BRAIN WIDTH(MM) 15.7 GROSS GRADE CODE: 1-SLIGHT, 2-MODERATE, 3-MARKED, P-PRESENT MICRO GRADE CODE: 1-MINIMAL; 2-MILD; 3-MODERATE; 4-SEVERE; P-PRESENT PGRHv4.63 06/05/2009 R:06/10/2009

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A30 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 1 INDIVIDUAL BRAIN WEIGHTS AND BRAIN MEASUREMENTS MALE GROUP: 0 PPM ANIMAL WEIGHT(G) LENGTH(MM) WIDTH(MM)----------------------------------------------------------------------------------------------------------------------------------- 3774 1.90 20.5 14.5 3776 2.14 21.4 15.7 3780 1.93 20.3 14.8 3787 2.19 21.7 15.2 3803 2.03 20.3 15.1 3826 2.08 21.1 15.7 3828 2.04 21.1 15.1 3832 2.21 21.1 15.7 3837 2.34 22.0 15.9 3843 2.23 21.7 15.7MEAN 2.11 21.1 15.3S.D. 0.139 0.60 0.47 N 10 10 10

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 TABLE A30 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 2 INDIVIDUAL BRAIN WEIGHTS AND BRAIN MEASUREMENTS MALE GROUP: 1000 PPM ANIMAL WEIGHT(G) LENGTH(MM) WIDTH(MM)----------------------------------------------------------------------------------------------------------------------------------- 3769 2.06 21.5 15.3 3772 2.26 22.4 15.1 3773 2.22 21.3 15.8 3781 2.14 20.8 15.6 3800 2.20 21.1 15.7 3805 1.98 21.3 15.8 3816 2.23 21.3 15.5 3818 2.18 22.0 15.4 3845 2.16 21.5 15.2 3846 2.27 21.4 15.5MEAN 2.17 21.5 15.5S.D. 0.091 0.45 0.24 N 10 10 10

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 TABLE A30 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 3 INDIVIDUAL BRAIN WEIGHTS AND BRAIN MEASUREMENTS MALE GROUP: 1500 PPM ANIMAL WEIGHT(G) LENGTH(MM) WIDTH(MM)----------------------------------------------------------------------------------------------------------------------------------- 3762 2.27 22.1 15.3 3768 2.17 21.5 15.4 3786 2.21 21.5 15.5 3788 2.16 21.1 14.7 3813 2.14 21.2 15.5 3819 2.11 21.2 15.6 3825 2.25 22.3 15.5 3833 2.01 20.5 15.6 3841 2.08 21.5 15.7 3842 2.06 21.3 15.4MEAN 2.15 21.4 15.4S.D. 0.083 0.51 0.28 N 10 10 10

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 TABLE A30 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 4 INDIVIDUAL BRAIN WEIGHTS AND BRAIN MEASUREMENTS MALE GROUP: 2000 PPM ANIMAL WEIGHT(G) LENGTH(MM) WIDTH(MM)----------------------------------------------------------------------------------------------------------------------------------- 3760 2.26 21.7 15.9 3779 2.09 20.3 15.8 3782 1.99 21.0 15.6 3784 2.26 21.3 15.3 3793 1.94 21.4 15.1 3794 2.19 21.6 15.2 3820 2.07 21.5 15.9 3821 2.10 21.5 15.4 3838 2.20 21.9 15.9MEAN 2.12 21.4 15.6S.D. 0.114 0.47 0.32 N 9 9 9

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 TABLE A30 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 5 INDIVIDUAL BRAIN WEIGHTS AND BRAIN MEASUREMENTS MALE GROUP: 2500 PPM ANIMAL WEIGHT(G) LENGTH(MM) WIDTH(MM)----------------------------------------------------------------------------------------------------------------------------------- 3763 2.09 21.5 15.0 3767 2.23 21.9 15.7 3771 2.14 21.6 15.8 3775 2.20 21.1 15.5 3795 2.37 22.6 16.1 3804 1.89 21.1 15.4 3814 2.05 21.0 15.4 3817 2.13 20.9 15.6 3822 2.11 21.7 15.4 3839 1.99 21.3 14.8MEAN 2.12 21.5 15.5S.D. 0.132 0.51 0.37 N 10 10 10

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 TABLE A30 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 6 INDIVIDUAL BRAIN WEIGHTS AND BRAIN MEASUREMENTS FEMALE GROUP: 0 PPM ANIMAL WEIGHT(G) LENGTH(MM) WIDTH(MM)----------------------------------------------------------------------------------------------------------------------------------- 3677 2.07 20.7 15.4 3686 1.79 20.3 15.0 3694 2.08 21.1 15.6 3696 2.13 21.6 15.4 3704 1.91 19.2 15.1 3714 2.07 21.7 15.2 3725 1.99 21.1 15.2 3738 1.88 20.4 15.0 3744 1.96 20.5 15.2 3757 2.16 21.3 15.3MEAN 2.00 20.8 15.2S.D. 0.119 0.74 0.19 N 10 10 10

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 TABLE A30 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 7 INDIVIDUAL BRAIN WEIGHTS AND BRAIN MEASUREMENTS FEMALE GROUP: 1000 PPM ANIMAL WEIGHT(G) LENGTH(MM) WIDTH(MM)----------------------------------------------------------------------------------------------------------------------------------- 3675 1.90 20.3 15.0 3695 2.21 21.7 15.5 3700 2.10 21.3 15.1 3702 1.97 20.5 15.0 3712 1.98 21.3 15.2 3713 2.03 21.1 15.6 3718 2.02 21.7 15.3 3720 2.07 21.3 15.4 3743 1.93 20.2 15.2 3747 2.09 21.3 15.3MEAN 2.03 21.1 15.3S.D. 0.092 0.55 0.20 N 10 10 10

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 TABLE A30 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 8 INDIVIDUAL BRAIN WEIGHTS AND BRAIN MEASUREMENTS FEMALE GROUP: 1500 PPM ANIMAL WEIGHT(G) LENGTH(MM) WIDTH(MM)----------------------------------------------------------------------------------------------------------------------------------- 3674 2.15 21.5 14.9 3701 1.82 20.2 14.5 3708 2.14 21.4 15.6 3711 2.11 21.3 15.4 3722 2.08 21.2 15.1 3726 2.06 21.0 15.7 3727 2.03 21.0 15.4 3731 1.98 20.3 15.3 3734 1.86 19.6 14.9 3756 1.97 21.3 15.0MEAN 2.02 20.9 15.2S.D. 0.113 0.63 0.37 N 10 10 10

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 TABLE A30 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 9 INDIVIDUAL BRAIN WEIGHTS AND BRAIN MEASUREMENTS FEMALE GROUP: 2000 PPM ANIMAL WEIGHT(G) LENGTH(MM) WIDTH(MM)----------------------------------------------------------------------------------------------------------------------------------- 3676 2.12 21.2 15.4 3678 2.00 21.5 15.0 3709 2.12 21.0 15.7 3716 2.07 21.2 15.6 3732 2.04 20.1 15.1 3739 2.12 21.4 15.4 3745 2.09 20.7 15.0 3746 2.09 21.2 15.5 3751 2.04 21.6 15.4 3754 2.11 21.1 15.1MEAN 2.08 21.1 15.3S.D. 0.042 0.43 0.25 N 10 10 10

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 TABLE A30 (SCHEDULED NECROPSY - PHASE II)

PROJECT NO.: 534015N A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 10 INDIVIDUAL BRAIN WEIGHTS AND BRAIN MEASUREMENTS FEMALE GROUP: 2500 PPM ANIMAL WEIGHT(G) LENGTH(MM) WIDTH(MM)----------------------------------------------------------------------------------------------------------------------------------- 3673 2.05 21.0 15.6 3679 2.11 21.7 15.5 3680 2.15 21.4 15.6 3685 1.86 20.6 14.7 3689 2.02 20.8 15.2 3698 2.25 21.6 15.8 3721 2.02 21.2 15.1 3730 2.01 21.0 15.6 3753 2.06 21.0 15.7MEAN 2.06 21.1 15.4S.D. 0.108 0.36 0.35 N 9 9 9 POFBWv4.14 06/05/2009 R:06/10/2009

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 INHALATION TABLE 1 (PHASE I)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 DAILY MEAN CHAMBER TEMPERATURE [DEGREES CELSIUS]----------------------------------------------------------------------------------------------------------------------------------- DATE GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- 03/01/09 22. 21. 21. 21. 22. 03/02/09 22. 22. 21. 21. 22. 03/03/09 22. 22. 20. 20. 22. 03/04/09 23. 22. 22. 22. 23. 03/05/09 23. 22. 22. 22. 23. 03/08/09 22. 22. 22. 22. 23. 03/09/09 23. 22. 21. 21. 22. 03/10/09 23. 21. 22. 22. 23. 03/11/09 23. 22. 22. 22. 23. 03/12/09 23. 22. 21. 21. 23. 03/15/09 23. 22. 21. 21. 23. 03/16/09 23. 22. 22. 22. 23. 03/17/09 23. 22. 22. 22. 23. 03/18/09 23. 23. 21. 21. 23. 03/19/09 23. 22. 22. 22. 23. 03/22/09 24. 22. 22. 22. 23. 03/23/09 22. 22. 21. 22. 23. 03/24/09 22. 22. 21. 21. 23. 03/25/09 23. 21. 21. 21. 22. 03/26/09 22. 21. 21. 21. 23.----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 23. 22. 21. 21. 23. S.D. 0.6 0.5 0.6 0.6 0.4 C.V.(%) 2.5 2.2 2.8 2.8 2.0 N 20 20 20 20 20 PINHv4.05 05/11/2009 R:06/17/2009

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 2 (PHASE II)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 DAILY MEAN CHAMBER TEMPERATURE [DEGREES CELSIUS]----------------------------------------------------------------------------------------------------------------------------------- DATE GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- 02/25/09 24. 23. 22. 22. 24. 02/26/09 24. 23. 23. 23. 24. 03/01/09 22. 21. 21. 21. 22. 03/02/09 22. 22. 21. 21. 22. 03/03/09 22. 22. 20. 20. 22. 03/04/09 23. 22. 22. 22. 23. 03/05/09 23. 22. 22. 22. 23. 03/08/09 22. 22. 22. 22. 23. 03/09/09 23. 22. 21. 21. 22. 03/10/09 23. 21. 22. 22. 23. 03/11/09 23. 22. 22. 22. 23. 03/12/09 23. 22. 21. 21. 23. 03/15/09 23. 22. 21. 21. 23. 03/16/09 23. 22. 22. 22. 23. 03/17/09 23. 22. 22. 22. 23. 03/18/09 23. 23. 21. 21. 23. 03/19/09 23. 22. 22. 22. 23. 03/21/09 22. 22. 20. 21. 22. 03/22/09 24. 22. 22. 22. 23. 03/23/09 22. 22. 21. 22. 23. 03/24/09 22. 22. 21. 21. 23. 03/25/09 23. 21. 21. 21. 22. 03/26/09 22. 21. 21. 21. 23.----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 23. 22. 21. 22. 23. S.D. 0.7 0.6 0.7 0.7 0.6 C.V.(%) 2.9 2.6 3.4 3.1 2.5 N 23 23 23 23 23 PINHv4.05 05/11/2009 R:06/10/2009

534015



3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 3 (PHASE I)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 DAILY MEAN CHAMBER RELATIVE HUMIDITY [%]----------------------------------------------------------------------------------------------------------------------------------- DATE GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- 03/01/09 57. 54. 67. 54. 49. 03/02/09 53. 50. 62. 50. 48. 03/03/09 55. 48. 61. 53. 48. 03/04/09 52. 46. 64. 51. 47. 03/05/09 54. 50. 64. 56. 55. 03/08/09 52. 47. 51. 51. 52. 03/09/09 49. 44. 45. 45. 52. 03/10/09 49. 44. 50. 51. 49. 03/11/09 54. 52. 50. 55. 56. 03/12/09 55. 54. 50. 51. 57. 03/15/09 56. 59. 51. 54. 54. 03/16/09 60. 60. 58. 59. 56. 03/17/09 57. 59. 56. 61. 60. 03/18/09 53. 55. 49. 52. 54. 03/19/09 52. 54. 53. 56. 49. 03/22/09 54. 52. 51. 52. 51. 03/23/09 53. 52. 48. 54. 54. 03/24/09 53. 51. 47. 50. 51. 03/25/09 57. 52. 49. 53. 53. 03/26/09 55. 49. 48. 51. 51.----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 54. 52. 54. 53. 52. S.D. 2.7 4.6 6.6 3.5 3.5 C.V.(%) 5.0 8.9 12.3 6.6 6.6 N 20 20 20 20 20 PINHv4.05 05/11/2009 R:06/17/2009

534015



3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 4 (PHASE II)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 DAILY MEAN CHAMBER RELATIVE HUMIDITY [%]----------------------------------------------------------------------------------------------------------------------------------- DATE GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- 02/25/09 61. 58. 65. 61. 59. 02/26/09 61. 54. 63. 56. 53. 03/01/09 57. 54. 67. 54. 49. 03/02/09 53. 50. 62. 50. 48. 03/03/09 55. 48. 61. 53. 48. 03/04/09 52. 46. 64. 51. 47. 03/05/09 54. 50. 64. 56. 55. 03/08/09 52. 47. 51. 51. 52. 03/09/09 49. 44. 45. 45. 52. 03/10/09 49. 44. 50. 51. 49. 03/11/09 54. 52. 50. 55. 56. 03/12/09 55. 54. 50. 51. 57. 03/15/09 56. 59. 51. 54. 54. 03/16/09 60. 60. 58. 59. 56. 03/17/09 57. 59. 56. 61. 60. 03/18/09 53. 55. 49. 52. 54. 03/19/09 52. 54. 53. 56. 49. 03/21/09 53. 53. 47. 52. 47. 03/22/09 54. 52. 51. 52. 51. 03/23/09 53. 52. 48. 54. 54. 03/24/09 53. 51. 47. 50. 51. 03/25/09 57. 52. 49. 53. 53. 03/26/09 55. 49. 48. 51. 51.----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 55. 52. 54. 53. 52. S.D. 3.2 4.5 7.0 3.7 3.7 C.V.(%) 5.9 8.7 12.9 6.9 7.1 N 23 23 23 23 23 PINHv4.05 05/11/2009 R:06/10/2009

534015



3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 5 (PHASE I)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 DAILY MEAN CHAMBER VENTILATION RATE [SLPM]----------------------------------------------------------------------------------------------------------------------------------- DATE GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- 03/01/09 237. 230. 232. 238. 239. 03/02/09 238. 229. 221. 238. 237. 03/03/09 238. 229. 209. 239. 236. 03/04/09 241. 231. 234. 232. 238. 03/05/09 242. 231. 236. 234. 240. 03/08/09 241. 231. 239. 235. 240. 03/09/09 240. 232. 237. 233. 237. 03/10/09 238. 233. 241. 230. 238. 03/11/09 238. 234. 242. 232. 239. 03/12/09 238. 228. 238. 226. 234. 03/15/09 237. 226. 239. 228. 231. 03/16/09 236. 225. 239. 227. 231. 03/17/09 236. 225. 238. 225. 230. 03/18/09 235. 225. 237. 233. 235. 03/19/09 235. 232. 242. 232. 233. 03/22/09 237. 228. 236. 228. 231. 03/23/09 236. 229. 235. 225. 232. 03/24/09 239. 226. 240. 227. 231. 03/25/09 241. 229. 237. 232. 236. 03/26/09 241. 230. 240. 228. 233.----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 238. 229. 236. 231. 235. S.D. 2.2 2.7 7.7 4.3 3.4 C.V.(%) 0.9 1.2 3.3 1.9 1.4 N 20 20 20 20 20 SLPM = STANDARD LITERS PER MINUTE PINHv4.05 05/11/2009 R:06/17/2009

534015



3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 6 (PHASE II)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 DAILY MEAN CHAMBER VENTILATION RATE [SLPM]----------------------------------------------------------------------------------------------------------------------------------- DATE GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- 02/25/09 216. 228. 234. 232. 233. 02/26/09 215. 232. 239. 239. 238. 03/01/09 237. 230. 232. 238. 239. 03/02/09 238. 229. 221. 238. 237. 03/03/09 238. 229. 209. 239. 236. 03/04/09 241. 231. 234. 232. 238. 03/05/09 242. 231. 236. 234. 240. 03/08/09 241. 231. 239. 235. 240. 03/09/09 240. 232. 237. 233. 237. 03/10/09 238. 233. 241. 230. 238. 03/11/09 238. 234. 242. 232. 239. 03/12/09 238. 228. 238. 226. 234. 03/15/09 237. 226. 239. 228. 231. 03/16/09 236. 225. 239. 227. 231. 03/17/09 236. 225. 238. 225. 230. 03/18/09 235. 225. 237. 233. 235. 03/19/09 235. 232. 242. 232. 233. 03/21/09 238. 230. 240. 228. 230. 03/22/09 237. 228. 236. 228. 231. 03/23/09 236. 229. 235. 225. 232. 03/24/09 239. 226. 240. 227. 231. 03/25/09 241. 229. 237. 232. 236. 03/26/09 241. 230. 240. 228. 233.----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 236. 229. 236. 231. 235. S.D. 6.8 2.6 7.3 4.4 3.4 C.V.(%) 2.9 1.1 3.1 1.9 1.4 N 23 23 23 23 23 SLPM = STANDARD LITERS PER MINUTE PINHv4.05 05/11/2009 R:06/10/2009

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 7

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 TEST ATMOSPHERE HOMOGENEITY DETERMINATION--------------------------------------------------------------------------------------------------------------------------------- TARGET: 1000 PPM CHAMBER #2--------------------------------------------------------------------------------------------------------------------------------- DATE SAMPLING LOCATION CONCENTRATION (PPM) % FROM REFERENCE MEAN %--------------------------------------------------------------------------------------------------------------------------------- 02/20/09 REFERENCE PORT 1072 LOWER REAR 1108 3.4 REFERENCE PORT 1077 LOWER REAR 1105 2.6 REFERENCE PORT 1070 LOWER REAR 1107 3.5 3.2 REFERENCE PORT 1081 LOWER FRONT 1038 -4.0 REFERENCE PORT 1071 LOWER FRONT 1040 -2.9 REFERENCE PORT 1058 LOWER FRONT 1031 -2.6 -3.2 REFERENCE PORT 1081 UPPER REAR 1088 0.6 REFERENCE PORT 1067 UPPER REAR 1086 1.8 REFERENCE PORT 1067 UPPER REAR 1081 1.3 1.2 REFERENCE PORT 1002 UPPER FRONT 961 -4.1 REFERENCE PORT 1003 UPPER FRONT 957 -4.6 REFERENCE PORT 998 UPPER FRONT 954 -4.4 -4.4-------------------------------------------------------------------------------------------------------------------------------- PPM = PARTS PER MILLION

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 7

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 TEST ATMOSPHERE HOMOGENEITY DETERMINATION--------------------------------------------------------------------------------------------------------------------------------- TARGET: 1500 PPM CHAMBER #3--------------------------------------------------------------------------------------------------------------------------------- DATE SAMPLING LOCATION CONCENTRATION (PPM) % FROM REFERENCE MEAN %--------------------------------------------------------------------------------------------------------------------------------- 02/18/09 REFERENCE PORT 1537 LOWER REAR 1595 3.8 REFERENCE PORT 1502 LOWER REAR 1563 4.1 REFERENCE PORT 1465 LOWER REAR 1519 3.7 3.9 REFERENCE PORT 1513 LOWER FRONT 1558 3.0 REFERENCE PORT 1498 LOWER FRONT 1524 1.7 REFERENCE PORT 1467 LOWER FRONT 1488 1.4 2.0 REFERENCE PORT 1508 UPPER REAR 1483 -1.7 REFERENCE PORT 1485 UPPER REAR 1474 -0.7 REFERENCE PORT 1463 UPPER REAR 1456 -0.5 -1.0 REFERENCE PORT 1478 UPPER FRONT 1468 -0.7 REFERENCE PORT 1482 UPPER FRONT 1459 -1.6 REFERENCE PORT 1467 UPPER FRONT 1452 -1.0 -1.1--------------------------------------------------------------------------------------------------------------------------------- PPM = PARTS PER MILLION

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 7

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 TEST ATMOSPHERE HOMOGENEITY DETERMINATION--------------------------------------------------------------------------------------------------------------------------------- TARGET: 2000 PPM CHAMBER #4--------------------------------------------------------------------------------------------------------------------------------- DATE SAMPLING LOCATION CONCENTRATION (PPM) % FROM REFERENCE MEAN %--------------------------------------------------------------------------------------------------------------------------------- 02/17/09 REFERENCE PORT 2019 LOWER REAR 1992 -1.3 REFERENCE PORT 2027 LOWER REAR 2004 -1.1 REFERENCE PORT 2035 LOWER REAR 1993 -2.1 -1.5 REFERENCE PORT 2014 LOWER FRONT 1979 -1.7 REFERENCE PORT 2031 LOWER FRONT 1991 -2.0 REFERENCE PORT 2031 LOWER FRONT 2009 -1.1 -1.6 REFERENCE PORT 2030 UPPER REAR 1988 -2.1 REFERENCE PORT 2045 UPPER REAR 1990 -2.7 REFERENCE PORT 2038 UPPER REAR 2013 -1.2 -2.0 REFERENCE PORT 2018 UPPER FRONT 1990 -1.4 REFERENCE PORT 2035 UPPER FRONT 1984 -2.5 REFERENCE PORT 2033 UPPER FRONT 2012 -1.0 -1.6--------------------------------------------------------------------------------------------------------------------------------- PPM = PARTS PER MILLION

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 7

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 TEST ATMOSPHERE HOMOGENEITY DETERMINATION--------------------------------------------------------------------------------------------------------------------------------- TARGET: 2500 PPM CHAMBER #5--------------------------------------------------------------------------------------------------------------------------------- DATE SAMPLING LOCATION CONCENTRATION (PPM) % FROM REFERENCE MEAN %--------------------------------------------------------------------------------------------------------------------------------- 02/16/09 REFERENCE PORT 2516 LOWER REAR 2472 -1.7 REFERENCE PORT 2500 LOWER REAR 2487 -0.5 REFERENCE PORT 2482 LOWER REAR 2462 -0.8 -1.0 REFERENCE PORT 2480 LOWER FRONT 2476 -0.2 REFERENCE PORT 2471 LOWER FRONT 2461 -0.4 REFERENCE PORT 2514 LOWER FRONT 2481 -1.3 -0.6 REFERENCE PORT 2497 UPPER REAR 2465 -1.3 REFERENCE PORT 2487 UPPER REAR 2474 -0.5 REFERENCE PORT 2501 UPPER REAR 2487 -0.6 -0.8 REFERENCE PORT 2495 UPPER FRONT 2490 -0.2 REFERENCE PORT 2471 UPPER FRONT 2497 1.1 REFERENCE PORT 2513 UPPER FRONT 2485 -1.1 -0.1--------------------------------------------------------------------------------------------------------------------------------- PPM = PARTS PER MILLION MANUALv1.0 04/06/2009 R:06/17/2009

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 8 (PHASE I)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 DAILY NOMINAL CONCENTRATION [PPM]----------------------------------------------------------------------------------------------------------------------------------- DATE GROUP: 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- 03/01/09 1037 1509 2112 2505 03/02/09 1035 1507 2102 2533 03/03/09 1038 1533 2079 2532 03/04/09 1017 1697 2151 2518 03/05/09 1019 1548 2128 2496 03/08/09 1022 1524 2122 2481 03/09/09 1023 1542 2137 2527 03/10/09 1015 1510 2171 2517 03/11/09 1018 1506 2149 2496 03/12/09 1037 1534 2206 2564 03/15/09 1051 1523 2171 2581 03/16/09 1046 1523 2195 2595 03/17/09 1049 1534 2214 2589 03/18/09 1061 1552 2165 2574 03/19/09 1026 1503 2152 2563 03/22/09 1037 1545 2173 2569 03/23/09 1037 1550 2210 2579 03/24/09 1052 1521 2198 2581 03/25/09 1029 1533 2137 2506 03/26/09 1023 1514 2176 2539----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 1034 1535 2157 2542 S.D. 13.3 41.1 37.5 35.8 C.V.(%) 1.29 2.68 1.74 1.41 N 20 20 20 20 MANUALv1.0 04/06/2009 R:06/17/2009

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 9 (PHASE II)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 DAILY NOMINAL CONCENTRATION [PPM]----------------------------------------------------------------------------------------------------------------------------------- DATE GROUP: 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- 02/25/09 1023 1605 2142 2554 02/26/09 1014 1608 2085 2509 03/01/09 1037 1509 2112 2505 03/02/09 1035 1507 2102 2533 03/03/09 1038 1533 2079 2532 03/04/09 1017 1697 2151 2518 03/05/09 1019 1548 2128 2496 03/08/09 1022 1524 2122 2481 03/09/09 1023 1542 2137 2527 03/10/09 1015 1510 2171 2517 03/11/09 1018 1506 2149 2496 03/12/09 1037 1534 2206 2564 03/15/09 1051 1523 2171 2581 03/16/09 1046 1523 2195 2595 03/17/09 1049 1534 2214 2589 03/18/09 1061 1552 2165 2574 03/19/09 1026 1503 2152 2563 03/21/09 1025 1518 2184 2589 03/22/09 1037 1545 2173 2569 03/23/09 1037 1550 2210 2579 03/24/09 1052 1521 2198 2581 03/25/09 1029 1533 2137 2506 03/26/09 1023 1514 2176 2539----------------------------------------------------------------------------------------------------------------------------------- GRAND MEAN 1032 1541 2155 2543 S.D. 13.3 43.6 38.6 35.5 C.V.(%) 1.29 2.83 1.79 1.40 N 23 23 23 23 MANUALv1.0 04/06/2009 R:06/10/2009

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 10 (PHASE I)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 1SPONSOR:AGC CHEMICAL DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- CHAMBER 1 CHAMBER 2 CHAMBER 3 CHAMBER 4 CHAMBER 5 CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION-----------------------------------------------------------------------------------------------------------------------------------STUDY DAY: 4MEAN 0. 985. 1469. 1997. 2465.SD 0.0 20.8 23.8 7.2 14.8CV(%) 0.00 2.11 1.62 0.36 0.60 N 10 10 10 10 10STUDY DAY: 5MEAN 0. 1002. 1450. 1989. 2480.SD 0.0 10.0 18.6 14.1 12.2CV(%) 0.00 0.99 1.28 0.71 0.49 N 10 10 10 10 10STUDY DAY: 6MEAN 0. 992. 1457. 1969. 2480.SD 0.0 7.5 16.2 7.8 14.9CV(%) 0.00 0.75 1.11 0.39 0.60 N 10 10 10 10 10STUDY DAY: 7MEAN 0. 1004. 1646. 1965. 2480.SD 0.0 7.2 87.7 10.6 13.0CV(%) 0.00 0.72 5.33 0.54 0.52 N 10 10 10 10 10STUDY DAY: 8MEAN 0. 1006. 1539. 1997. 2484.SD 0.0 8.4 33.8 17.3 14.6CV(%) 0.00 0.83 2.20 0.86 0.59 N 10 10 10 10 10CV (%) = COEFFICIENT OF VARIATIONCONCENTRATION IN: PPM

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 10 (PHASE I)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 2SPONSOR:AGC CHEMICAL DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- CHAMBER 1 CHAMBER 2 CHAMBER 3 CHAMBER 4 CHAMBER 5 CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION-----------------------------------------------------------------------------------------------------------------------------------STUDY DAY: 11MEAN 0. 1019. 1529. 1994. 2507.SD 0.0 6.8 9.1 7.6 7.3CV(%) 0.00 0.66 0.60 0.38 0.29 N 10 10 10 10 10STUDY DAY: 12MEAN 0. 1035. 1533. 2004. 2500.SD 0.0 11.0 10.1 13.7 10.3CV(%) 0.00 1.07 0.66 0.68 0.41 N 10 10 10 10 10STUDY DAY: 13MEAN 0. 1028. 1509. 2007. 2515.SD 0.0 10.7 20.7 9.5 31.8CV(%) 0.00 1.04 1.37 0.47 1.26 N 10 10 10 10 10STUDY DAY: 14MEAN 0. 1005. 1510. 2013. 2490.SD 0.0 7.7 5.4 11.0 17.5CV(%) 0.00 0.76 0.36 0.55 0.70 N 10 10 10 10 10STUDY DAY: 15MEAN 0. 1010. 1500. 2019. 2501.SD 0.0 18.1 27.6 37.5 23.6CV(%) 0.00 1.79 1.84 1.86 0.94 N 10 10 10 10 10CV (%) = COEFFICIENT OF VARIATIONCONCENTRATION IN: PPM

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 10 (PHASE I)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 3SPONSOR:AGC CHEMICAL DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- CHAMBER 1 CHAMBER 2 CHAMBER 3 CHAMBER 4 CHAMBER 5 CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION-----------------------------------------------------------------------------------------------------------------------------------STUDY DAY: 18MEAN 0. 1002. 1535. 2004. 2525.SD 0.0 4.7 8.9 7.0 18.9CV(%) 0.00 0.47 0.58 0.35 0.75 N 10 10 10 10 10STUDY DAY: 19MEAN 0. 1010. 1523. 2025. 2523.SD 0.0 10.0 7.4 21.4 8.8CV(%) 0.00 0.99 0.49 1.05 0.35 N 10 10 10 10 10STUDY DAY: 20MEAN 0. 1010. 1541. 2024. 2522.SD 0.0 5.7 11.8 11.9 13.1CV(%) 0.00 0.56 0.76 0.59 0.52 N 10 10 10 10 10STUDY DAY: 21MEAN 0. 1025. 1548. 2008. 2537.SD 0.0 13.9 27.6 22.6 17.6CV(%) 0.00 1.35 1.78 1.13 0.69 N 10 10 10 10 10STUDY DAY: 22MEAN 0. 1006. 1505. 1988. 2523.SD 0.0 10.9 17.3 9.6 21.7CV(%) 0.00 1.08 1.15 0.49 0.86 N 10 10 10 10 10CV (%) = COEFFICIENT OF VARIATIONCONCENTRATION IN: PPM

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 10 (PHASE I)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 4SPONSOR:AGC CHEMICAL DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- CHAMBER 1 CHAMBER 2 CHAMBER 3 CHAMBER 4 CHAMBER 5 CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION-----------------------------------------------------------------------------------------------------------------------------------STUDY DAY: 25MEAN 0. 1013. 1535. 1963. 2514.SD 0.0 15.4 55.5 224.0 37.7CV(%) 0.00 1.52 3.61 11.41 1.50 N 10 10 10 10 10STUDY DAY: 26MEAN 0. 1008. 1553. 2036. 2518.SD 0.0 5.3 18.3 8.5 11.1CV(%) 0.00 0.53 1.18 0.42 0.44 N 10 10 10 10 10STUDY DAY: 27MEAN 0. 1016. 1528. 2024. 2508.SD 0.0 25.6 5.8 7.1 29.6CV(%) 0.00 2.52 0.38 0.35 1.18 N 10 10 10 10 10STUDY DAY: 28MEAN 0. 1032. 1557. 1997. 2483.SD 0.0 5.6 28.6 18.4 10.1CV(%) 0.00 0.55 1.84 0.92 0.41 N 10 10 10 10 10STUDY DAY: 29MEAN 0. 1009. 1527. 2020. 2517.SD 0.0 4.6 7.2 30.1 39.4CV(%) 0.00 0.45 0.47 1.49 1.56 N 10 10 10 10 10CV (%) = COEFFICIENT OF VARIATIONCONCENTRATION IN: PPM

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 10 (PHASE I)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY OF ASAHIKLIN AE-3000 PAGE 5SPONSOR:AGC CHEMICAL DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- CHAMBER 1 CHAMBER 2 CHAMBER 3 CHAMBER 4 CHAMBER 5 CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION-----------------------------------------------------------------------------------------------------------------------------------STUDY DAYS 4 THROUGH 29MEAN 0. 1011. 1525. 2002. 2504.SD 0.0 12.4 41.4 20.4 19.9CV(%) 0.00 1.23 2.72 1.02 0.79 N 20 20 20 20 20-----------------------------------------------------------------------------------------------------------------------------------CV (%) = COEFFICIENT OF VARIATIONCONCENTRATION IN: PPM PCHCSUv4.06 06/17/2009 R:06/17/2009

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 11 (PHASE II)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- CHAMBER 1 CHAMBER 2 CHAMBER 3 CHAMBER 4 CHAMBER 5 CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION-----------------------------------------------------------------------------------------------------------------------------------STUDY DAY: 0MEAN 0. 1006. 1590. 2083. 2579.SD 0.0 8.7 56.5 25.9 27.5CV(%) 0.00 0.86 3.55 1.24 1.07 N 10 10 10 10 10STUDY DAY: 1MEAN 0. 1037. 1636. 2056. 2567.SD 0.0 9.2 141.0 7.0 16.0CV(%) 0.00 0.89 8.62 0.34 0.63 N 10 10 10 10 10STUDY DAY: 4MEAN 0. 985. 1469. 1997. 2465.SD 0.0 20.8 23.8 7.2 14.8CV(%) 0.00 2.11 1.62 0.36 0.60 N 10 10 10 10 10STUDY DAY: 5MEAN 0. 1002. 1450. 1989. 2480.SD 0.0 10.0 18.6 14.1 12.2CV(%) 0.00 0.99 1.28 0.71 0.49 N 10 10 10 10 10STUDY DAY: 6MEAN 0. 992. 1457. 1969. 2480.SD 0.0 7.5 16.2 7.8 14.9CV(%) 0.00 0.75 1.11 0.39 0.60 N 10 10 10 10 10CV (%) = COEFFICIENT OF VARIATIONCONCENTRATION IN: PPM

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 11 (PHASE II)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- CHAMBER 1 CHAMBER 2 CHAMBER 3 CHAMBER 4 CHAMBER 5 CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION-----------------------------------------------------------------------------------------------------------------------------------STUDY DAY: 7MEAN 0. 1004. 1646. 1965. 2480.SD 0.0 7.2 87.7 10.6 13.0CV(%) 0.00 0.72 5.33 0.54 0.52 N 10 10 10 10 10STUDY DAY: 8MEAN 0. 1006. 1539. 1997. 2484.SD 0.0 8.4 33.8 17.3 14.6CV(%) 0.00 0.83 2.20 0.86 0.59 N 10 10 10 10 10STUDY DAY: 11MEAN 0. 1019. 1529. 1994. 2507.SD 0.0 6.8 9.1 7.6 7.3CV(%) 0.00 0.66 0.60 0.38 0.29 N 10 10 10 10 10STUDY DAY: 12MEAN 0. 1035. 1533. 2004. 2500.SD 0.0 11.0 10.1 13.7 10.3CV(%) 0.00 1.07 0.66 0.68 0.41 N 10 10 10 10 10STUDY DAY: 13MEAN 0. 1028. 1509. 2007. 2515.SD 0.0 10.7 20.7 9.5 31.8CV(%) 0.00 1.04 1.37 0.47 1.26 N 10 10 10 10 10CV (%) = COEFFICIENT OF VARIATIONCONCENTRATION IN: PPM

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 11 (PHASE II)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- CHAMBER 1 CHAMBER 2 CHAMBER 3 CHAMBER 4 CHAMBER 5 CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION-----------------------------------------------------------------------------------------------------------------------------------STUDY DAY: 14MEAN 0. 1005. 1510. 2013. 2490.SD 0.0 7.7 5.4 11.0 17.5CV(%) 0.00 0.76 0.36 0.55 0.70 N 10 10 10 10 10STUDY DAY: 15MEAN 0. 1010. 1500. 2019. 2501.SD 0.0 18.1 27.6 37.5 23.6CV(%) 0.00 1.79 1.84 1.86 0.94 N 10 10 10 10 10STUDY DAY: 18MEAN 0. 1002. 1535. 2004. 2525.SD 0.0 4.7 8.9 7.0 18.9CV(%) 0.00 0.47 0.58 0.35 0.75 N 10 10 10 10 10STUDY DAY: 19MEAN 0. 1010. 1523. 2025. 2523.SD 0.0 10.0 7.4 21.4 8.8CV(%) 0.00 0.99 0.49 1.05 0.35 N 10 10 10 10 10STUDY DAY: 20MEAN 0. 1010. 1541. 2024. 2522.SD 0.0 5.7 11.8 11.9 13.1CV(%) 0.00 0.56 0.76 0.59 0.52 N 10 10 10 10 10CV (%) = COEFFICIENT OF VARIATIONCONCENTRATION IN: PPM

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 11 (PHASE II)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 4 DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- CHAMBER 1 CHAMBER 2 CHAMBER 3 CHAMBER 4 CHAMBER 5 CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION-----------------------------------------------------------------------------------------------------------------------------------STUDY DAY: 21MEAN 0. 1025. 1548. 2008. 2537.SD 0.0 13.9 27.6 22.6 17.6CV(%) 0.00 1.35 1.78 1.13 0.69 N 10 10 10 10 10STUDY DAY: 22MEAN 0. 1006. 1505. 1988. 2523.SD 0.0 10.9 17.3 9.6 21.7CV(%) 0.00 1.08 1.15 0.49 0.86 N 10 10 10 10 10STUDY DAY: 24MEAN 0. 1010. 1516. 2021. 2526.SD 0.0 18.0 11.6 21.9 22.9CV(%) 0.00 1.79 0.77 1.08 0.91 N 10 10 10 10 10STUDY DAY: 25MEAN 0. 1013. 1535. 1963. 2514.SD 0.0 15.4 55.5 224.0 37.7CV(%) 0.00 1.52 3.61 11.41 1.50 N 10 10 10 10 10STUDY DAY: 26MEAN 0. 1008. 1553. 2036. 2518.SD 0.0 5.3 18.3 8.5 11.1CV(%) 0.00 0.53 1.18 0.42 0.44 N 10 10 10 10 10CV (%) = COEFFICIENT OF VARIATIONCONCENTRATION IN: PPM

534015



3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
 INHALATION TABLE 11 (PHASE II)

PROJECT NO.:WIL-534015I A 28-DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 5 DAILY MEAN TEST ATMOSPHERE CONCENTRATIONS-----------------------------------------------------------------------------------------------------------------------------------GROUP: 0 PPM 1000 PPM 1500 PPM 2000 PPM 2500 PPM----------------------------------------------------------------------------------------------------------------------------------- CHAMBER 1 CHAMBER 2 CHAMBER 3 CHAMBER 4 CHAMBER 5 CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION CONCENTRATION-----------------------------------------------------------------------------------------------------------------------------------STUDY DAY: 27MEAN 0. 1016. 1528. 2024. 2508.SD 0.0 25.6 5.8 7.1 29.6CV(%) 0.00 2.52 0.38 0.35 1.18 N 10 10 10 10 10STUDY DAY: 28MEAN 0. 1032. 1557. 1997. 2483.SD 0.0 5.6 28.6 18.4 10.1CV(%) 0.00 0.55 1.84 0.92 0.41 N 10 10 10 10 10STUDY DAY: 29MEAN 0. 1009. 1527. 2020. 2517.SD 0.0 4.6 7.2 30.1 39.4CV(%) 0.00 0.45 0.47 1.49 1.56 N 10 10 10 10 10ALL STUDY DAYS COMBINEDMEAN 0. 1012. 1532. 2009. 2511.SD 0.0 12.9 46.8 27.6 27.4CV(%) 0.00 1.27 3.05 1.37 1.09 N 23 23 23 23 23-----------------------------------------------------------------------------------------------------------------------------------CV (%) = COEFFICIENT OF VARIATIONCONCENTRATION IN: PPM PCHCSUv4.06 04/06/2009 R:06/17/2009

534015



3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION


	
 

	
 

   
 


 

   
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534015



3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
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534015



3DJHRI

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!&	'/	

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.
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534015



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-.)&* ,&() *# B # +#$8 ,& ##$## /+)'," 8 #, 0'!',"2 
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534015



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'(+)$ = $/)$#$, ,'>$ .)&* ,&() * %  


   */!$ )&*

.$ ,&) ($ "!'8$) %,$) &*/!$,'& % '* ! ?/&#+)$#1  !"5$8 9

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  */!$1  !"5$8 9 )-. 7

534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
'(+)$ ;= $/)$#$, ,'>$ .)&* ,&() * %  ') 
A$-,'&1  !"5$8 9 )-. 7

.$ #,&) ($ -"!'8$) # */!$# B$)$ )$ ##$##$8 &  /)'! 7 ,& -&%')* ,. , ,.$ ,$#,

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534015



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COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
   	 
 
 
 
 
	     	

















	






































	




































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534015



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%)&* 'A$-,'& &% ,.$ ,$#, #+0#, -$2  '(+)$ ; )$/)$#$,# 0! C ') 'A$-,'& 8

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$?/$-,$8 -.$*'- ! #,)+-,+)$2

534015



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 ! 9 

534015



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Test Analyzed Mean

Substance Date Ref # Run # Ret Time Area Percent Area Relative Area

( WIL log no. ) ( 534015 - ) (%) (%)

8137A#1 23-Feb-09 1 - 1 11 3.94 5604628 100 100

8137A#1 23-Feb-09 1 - 1 12 3.94 5848375 100

534015.xls 1

Printed: 04/29/09 8:38 AM

TOXICITY AND NEUROTOXICITY STUDY

A 28-DAY INHALATION COMBINED

(Analyzed 23 February 2009)

Table 1: Pre-Use Purity Assessment Of ASAHIKLIN AE-3000

OF ASAHIKLIN AE-3000 IN SPRAGUE-DAWLEY RATS

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Test Analyzed Mean

Substance Date Ref # Run # Ret Time Area Percent Area Relative Area

( WIL log no. ) ( 534015 - ) (%) (%)

8137A#8 26-Mar-09 5 - 1 23 5.36 4016536 100 100

8137A#8 26-Mar-09 5 - 1 24 5.36 4220214 100

534015.xls 2

Printed: 04/29/09 8:38 AM

TOXICITY AND NEUROTOXICITY STUDY

A 28-DAY INHALATION COMBINED

(Analyzed 26 March 2009)

Table 2: Post-Use Purity Assessment Of ASAHIKLIN AE-3000

OF ASAHIKLIN AE-3000 IN SPRAGUE-DAWLEY RATS

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Percent Mean Mean Purity

Sample No Ref # Run # Area Relative Area % of Time Zero

(WIL log no.) ( % ) ( % ) (%)

8137 A#8 5 - 1 24 100 100 100

5 - 1 25 100

Sample No

(WIL log no.)

8137 A#1

534015.xls 3

Printed: 07/17/09 2:50 PM

A 28-DAY INHALATION COMBINED

TOXICITY AND NEUROTOXICITY STUDY

OF ASAHIKLIN AE-3000 IN SPRAGUE-DAWLEY RATS

100

Time Zero Purity Value (%)

Table 3: 31-Day Room Temperature Stability Assessment Of ASAHIKLIN AE-3000

( 534015 - )

(Analyzed 26 March 2009)

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 PRETEST CLINICAL OBSERVATIONS (MALES)

PROJECT NO.: 534015Q A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS ----- M A L E ---------------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 02-10-09 TO 02-17-09 GROUP: 1-----------------------------------------------------------------------------------------------------------------------------------NORMAL-NO SIGNIFICANT CLINICAL OBSERVATIONS 174/88DISPOSITION-EUTHANIZED IN EXTREMIS 1/ 1BEHAVIOR/CNS-HUNCHED POSTURE 1/ 1BODY/INTEGUMENT-BODY PALE 1/ 1-BODY COOL 1/ 1-UNKEMPT APPEARANCE 1/ 1EYES/EARS/NOSE-DRIED RED MATERIAL RIGHT EAR 1/ 1EXCRETA-DECREASED DEFECATION 1/ 1----------------------------------------------------------------------------------------------------------------------------------- 1- PRETEST PCSUv4.07 07/15/2009

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 PRETEST CLINICAL OBSERVATIONS (FEMALES)

PROJECT NO.: 534015P A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 SUMMARY OF CLINICAL FINDINGS: TOTAL OCCURRENCE/NO. OF ANIMALS ----- F E M A L E ---------------------------------------------------------------------------------------------------------------------------------------- TABLE RANGE: 02-10-09 TO 02-17-09 GROUP: 1-----------------------------------------------------------------------------------------------------------------------------------NORMAL-NO SIGNIFICANT CLINICAL OBSERVATIONS 168/86BODY/INTEGUMENT-SCABBING RIGHT LATERAL THORACIC AREA 2/ 1-HAIR LOSS LEFT FORELIMB 3/ 3-HAIR LOSS RIGHT FORELIMB 1/ 1EYES/EARS/NOSE-DRIED RED MATERIAL RIGHT EAR 1/ 1----------------------------------------------------------------------------------------------------------------------------------- 1- PRETEST PCSUv4.07 07/15/2009

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 PRETEST BODY WEIGHTS (MALES)

PROJECT NO.: 534015Q A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 SUMMARY OF BODY WEIGHTS [G]----------------------------------------------------------------------------------------------------------------------------------- MALES GROUP: PRETEST----------------------------------------------------------------------------------------------------------------------------------- DAY -12 MEAN 168. S.D. 8.5 S.E. 0.9 N 88 -8 MEAN 208. S.D. 14.5 S.E. 1.5 N 88----------------------------------------------------------------------------------------------------------------------------------- PBFSTv5.30 06/18/2009

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 PRETEST BODY WEIGHTS (FEMALES)

PROJECT NO.: 534015P A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 SUMMARY OF BODY WEIGHTS [G]----------------------------------------------------------------------------------------------------------------------------------- FEMALES GROUP: PRETEST----------------------------------------------------------------------------------------------------------------------------------- DAY -12 MEAN 148. S.D. 7.6 S.E. 0.8 N 87 -8 MEAN 168. S.D. 8.8 S.E. 0.9 N 87----------------------------------------------------------------------------------------------------------------------------------- PBFSTv5.30 06/18/2009

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TEST SYSTEM:

DATE IN TIME INDATE OUT TIME OUT

02/10/09 11:0003/27/09 08:00

RAT

LOW HUMIDITY %RH:HIGH HUMIDITY %RH:

HIGH TEMPERATURE °F: LOW TEMPERATURE °F: ROOM SPECIFICATIONS: 66.0 76.0 30.0

70.0

STUDY SPECIFICATIONS:

HIGH TEMPERATURE °C: LOW TEMPERATURE °C: 18.9 24.4

534015

B ROOM 50

DATE

SECONDARY TEMP PRIMARY HUM SECONDARY HUM PRIMARY TEMP

MEAN (°F) MEAN (°C) MEAN (°F) MEAN (°C) MEAN (%RH) MEAN (%RH)

02/10/09 71.0 45.5 21.602/11/09 70.9 45.1 21.602/12/09 71.2 39.5 21.802/13/09 70.9 39.9 21.602/14/09 71.0 39.5 21.702/15/09 70.9 39.4 21.602/16/09 70.4 40.2 21.302/17/09 71.3 39.6 21.802/18/09 70.8 40.1 21.602/19/09 71.1 39.3 21.702/20/09 70.5 40.6 21.402/21/09 71.6 39.1 22.002/22/09 71.2 40.3 21.802/23/09 71.3 39.9 21.802/24/09 70.9 41.1 21.602/25/09 70.9 42.3 21.602/26/09 71.0 41.8 21.702/27/09 70.7 43.0 21.502/28/09 70.5 41.1 21.4

A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY

534015

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TEMPERATURE/HUMIDITY - STUDY SUMMARY REPORT PROJECT NO.:WILSPONSOR:

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DATE

SECONDARY TEMP PRIMARY HUM SECONDARY HUM PRIMARY TEMP

MEAN (°F) MEAN (°C) MEAN (°F) MEAN (°C) MEAN (%RH) MEAN (%RH)

03/01/09 70.7 42.5 21.503/02/09 70.2 43.0 21.203/03/09 71.1 42.6 21.703/04/09 70.8 43.0 21.603/05/09 70.6 41.3 21.503/06/09 71.0 45.4 21.703/07/09 70.8 49.3 21.603/08/09 70.7 46.7 21.503/09/09 70.9 43.5 21.603/10/09 70.6 44.7 21.503/11/09 70.7 47.1 21.503/12/09 70.7 43.6 21.503/13/09 70.9 43.3 21.603/14/09 71.3 42.6 21.803/15/09 70.9 44.5 21.603/16/09 71.0 43.4 21.703/17/09 70.9 44.6 21.603/18/09 70.7 43.3 21.503/19/09 71.2 41.1 21.803/20/09 70.9 42.1 21.603/21/09 70.0 43.6 21.103/22/09 71.6 40.9 22.003/23/09 70.4 42.6 21.3

A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY

534015

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TEMPERATURE/HUMIDITY - STUDY SUMMARY REPORT PROJECT NO.:WILSPONSOR:

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DATE

SECONDARY TEMP PRIMARY HUM SECONDARY HUM PRIMARY TEMP

MEAN (°F) MEAN (°C) MEAN (°F) MEAN (°C) MEAN (%RH) MEAN (%RH)

03/24/09 70.4 43.0 21.303/25/09 71.0 45.4 21.703/26/09 70.9 42.9 21.603/27/09 69.9 41.1 21.0SUMMARY OF DAILY MEANS MEAN MIN MAX

70.9 69.9 71.6 PRIMARY TEMP °F:

PRIMARY TEMP °C:PRIMARY HUM %RH:N DAYS

21.6 21.0 22.042.5 39.1 49.346

SECONDARY TEMP °F:SECONDARY TEMP °C:SECONDARY HUM %RH:

A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY

534015

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TEMPERATURE/HUMIDITY - STUDY SUMMARY REPORT PROJECT NO.:WILSPONSOR:

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MEAN

MINMAXSDN SAMPLESFIRST DAYLAST DAYN DAYS

B ROOM 50 SUMMARY OF HOURLY VALUES

70.9 42.5

68.473.91053

33.458.61053

1.61 3.73PRIMARY TEMP PRIMARY HUM02/10/0903/27/0946

°F°F°F

SECONDARY TEMP SECONDARY HUM

%RH%RH%RH

0.05 0.11 SE

21.620.223.30.89

°C°C°C

0.03

A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY

534015

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TEMPERATURE/HUMIDITY - STUDY SUMMARY REPORT PROJECT NO.:WILSPONSOR:

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STUDY 534015 SUMMARY OF HOURLY VALUES

PRIMARY TEMP

MEANMINMAXSDN SAMPLESFIRST DAYLAST DAY

70.9 42.5

68.473.91053

33.458.61053

1.61

PRIMARY HUM3.73

02/10/0903/27/0946

°F°F°F

N DAYS

SECONDARY TEMP SECONDARY HUM

%RH%RH%RH

0.05 0.11 SE

21.620.223.30.89

°C°C°C

0.03

A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY

534015

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TEMPERATURE/HUMIDITY - STUDY SUMMARY REPORT PROJECT NO.:WILSPONSOR:

WIL METASYS VERSION 2.16 07:52 15-May-09

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 UNSCHEDULED CLINICAL OBSERVATIONS (COMBINED PHASES)

PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 1 INDIVIDUAL CLINICAL OBSERVATIONS [POSITIVE FINDINGS ONLY] TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3799 M 2000 PPM BEHAVIOR/CNS 03-25-09 11:48 P INTERMITTENT TREMORS 03-26-09 11:00 P CONTINUOUS TREMORS 3809 M 2000 PPM BEHAVIOR/CNS 03-22-09 11:20 P INTERMITTENT TREMORS 3812 M 2000 PPM BEHAVIOR/CNS 03-23-09 11:13 P INTERMITTENT TREMORS 3783 M 2500 PPM BEHAVIOR/CNS 03-18-09 10:01 P INTERMITTENT TREMORS 03-23-09 11:05 P INTERMITTENT TREMORS 03-25-09 11:47 P INTERMITTENT TREMORS 03-26-09 10:53 P CONTINUOUS TREMORS 3795 M 2500 PPM BEHAVIOR/CNS 03-18-09 10:00 P INTERMITTENT TREMORS 03-25-09 11:43 P INTERMITTENT TREMORS 3810 M 2500 PPM BEHAVIOR/CNS 03-25-09 11:48 P INTERMITTENT TREMORS 3810 M 2500 PPM ORAL/DENTAL 03-22-09 11:13 P SALIVATION 3831 M 2500 PPM BEHAVIOR/CNS 03-18-09 10:31 P INTERMITTENT TREMORS 03-19-09 8:40 P CONVULSIONS, CLONIC 03-22-09 11:11 P INTERMITTENT TREMORS 03-22-09 11:18 P CONVULSIONS, CLONIC 03-23-09 11:04 P CONVULSIONS, CLONIC 03-24-09 10:40 P CONVULSIONS, CLONIC 03-25-09 11:36 P CONVULSIONS, CLONIC 03-25-09 11:40 P POPCORN SEIZURES 03-26-09 10:52 P CONVULSIONS, CLONIC 3831 M 2500 PPM EYES/EARS/NOSE 03-24-09 10:40 P WET RED MATERIAL AROUND NOSE 03-25-09 11:42 P WET RED MATERIAL AROUND NOSE 3831 M 2500 PPM ORAL/DENTAL 03-18-09 10:09 P WET RED MATERIAL AROUND MOUTH 03-22-09 11:18 P SALIVATION 03-23-09 11:06 P WET RED MATERIAL AROUND MOUTH 03-25-09 11:42 P WET RED MATERIAL AROUND MOUTH 03-26-09 10:55 P WET CLEAR MATERIAL AROUND MOUTH 3839 M 2500 PPM BEHAVIOR/CNS 03-18-09 10:08 P INTERMITTENT TREMORS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 2 INDIVIDUAL CLINICAL OBSERVATIONS [POSITIVE FINDINGS ONLY] TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3839 M 2500 PPM BEHAVIOR/CNS 03-19-09 8:45 P INTERMITTENT TREMORS 03-19-09 9:04 P INTERMITTENT TREMORS 03-21-09 8:13 P INTERMITTENT TREMORS 03-22-09 11:05 P INTERMITTENT TREMORS 3720 F 1000 PPM BEHAVIOR/CNS 03-04-09 7:07 P INTERMITTENT TREMORS 3740 F 2000 PPM BEHAVIOR/CNS 03-18-09 10:04 P INTERMITTENT TREMORS 03-22-09 11:10 P INTERMITTENT TREMORS 03-24-09 11:12 P INTERMITTENT TREMORS 03-25-09 11:46 P INTERMITTENT TREMORS 3680 F 2500 PPM ORAL/DENTAL 03-21-09 7:40 P SALIVATION 3685 F 2500 PPM BEHAVIOR/CNS 03-18-09 10:05 P INTERMITTENT TREMORS 03-23-09 11:10 P INTERMITTENT TREMORS 03-26-09 10:52 P INTERMITTENT TREMORS 3688 F 2500 PPM BEHAVIOR/CNS 03-23-09 11:14 P INTERMITTENT TREMORS 3689 F 2500 PPM BEHAVIOR/CNS 03-18-09 9:59 P INTERMITTENT TREMORS 03-21-09 7:50 P INTERMITTENT TREMORS 03-22-09 11:15 P INTERMITTENT TREMORS 03-23-09 11:09 P INTERMITTENT TREMORS 3717 F 2500 PPM BEHAVIOR/CNS 03-19-09 9:13 P INTERMITTENT TREMORS 03-25-09 11:45 P INTERMITTENT TREMORS 03-26-09 10:54 P INTERMITTENT TREMORS 3742 F 2500 PPM BEHAVIOR/CNS 03-18-09 9:53 P POPCORN SEIZURES 03-19-09 8:33 P CONVULSIONS, CLONIC 03-21-09 7:37 P CONVULSIONS, CLONIC 03-22-09 11:07 P CONVULSIONS, CLONIC 03-22-09 11:39 P CONVULSIONS, CLONIC 03-22-09 11:39 P HYPERACTIVITY 3742 F 2500 PPM EYES/EARS/NOSE 03-18-09 10:12 P LACRIMATION 3742 F 2500 PPM ORAL/DENTAL 03-18-09 10:12 P WET CLEAR MATERIAL AROUND MOUTH-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT

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PROJECT NO.: 534015 A 28 DAY RAT INHALATION TOX/NEUROTOX STUDY PAGE 3 INDIVIDUAL CLINICAL OBSERVATIONS [POSITIVE FINDINGS ONLY] TABLE RANGE: 02-25-09 TO 03-26-09----------------------------------------------------------------------------------------------------------------------------------- ANIMAL SEX GROUP CATEGORY DATE TIME GRADE OBSERVATIONS----------------------------------------------------------------------------------------------------------------------------------- 3742 F 2500 PPM ORAL/DENTAL 03-21-09 8:11 P SALIVATION 03-22-09 11:07 P SALIVATION 3753 F 2500 PPM BEHAVIOR/CNS 03-19-09 9:16 P INTERMITTENT TREMORS 3755 F 2500 PPM BEHAVIOR/CNS 03-23-09 11:05 P INTERMITTENT TREMORS 03-26-09 10:54 P INTERMITTENT TREMORS 03-26-09 10:59 P CONVULSIONS, CLONIC 3755 F 2500 PPM ORAL/DENTAL 03-23-09 11:05 P WET CLEAR MATERIAL AROUND MOUTH 3758 F 2500 PPM BEHAVIOR/CNS 03-23-09 11:10 P INTERMITTENT TREMORS-----------------------------------------------------------------------------------------------------------------------------------GRADE CODE: 1 - SLIGHT 2 - MODERATE 3 - SEVERE P - PRESENT PCRDv4.15 06/10/2009 R:06/18/2009

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A 28-DAY INHALATION COMBINED

TOXICITY AND NEUROTOXICITY STUDY

OF ASAHIKLIN AE-3000 IN SPRAGUE-DAWLEY RATS

PATHOLOGY REPORT

Pathology Department

WIL Research Laboratories, LLC

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TABLE OF CONTENTS

Page

Table Of Contents......................................................................................2

1. Introduction................................................................................................4

2. Study Design...............................................................................................4

3. Methods.......................................................................................................5

3.1. Exposure Methods: ......................................................................................5

3.2. General Toxicology Phase ± Phase I ...........................................................5

3.2.1. Clinical Pathology........................................................................................5

3.2.1.1. Hematology And Coagulation .....................................................................6

3.2.1.2. Serum Chemistry .........................................................................................7

3.2.2. Anatomic Pathology.....................................................................................7

3.2.2.1. Macroscopic Examination ...........................................................................7

3.2.3. Organ Weights .............................................................................................9

3.2.4. Microscopic Examination ............................................................................9

3.3. Neuropathology ± Phase II...........................................................................9

3.3.1. Anatomic Pathology.....................................................................................9

3.3.1.1. Macroscopic Examination ...........................................................................9

3.3.1.2. Microscopic Examination ..........................................................................10

3.4. Abbreviations.............................................................................................12

3.5. Data Interpretation .....................................................................................12

4. Results For Phase I ..................................................................................13

4.1. Survival......................................................................................................13

4.2. Clinical Pathology......................................................................................13

4.2.1. Hematology And Coagulation ...................................................................13

4.2.2. Serum Chemistry .......................................................................................13

4.3. Gross Observations ....................................................................................13

4.4. Organ Weights ...........................................................................................13

4.5. Histologic Changes ....................................................................................13

5. Results For Phase II.................................................................................14

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Page

5.1. Survival......................................................................................................14

5.2. Brain Weights and Measures .....................................................................14

5.3. Histologic Changes ....................................................................................14

6. Conclusions...............................................................................................14

7. Report Submission...................................................................................15

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1. INTRODUCTION

The objective of this study was to evaluate potential toxic and neurotoxic effects of the 

test substance when administered via whole-body inhalation to rats for 4 weeks on a 

5-day per week basis (minimum of 20 total exposures). In addition, a neurotoxicity 

screen used satellite animals which included assessment of functional observational 

battery (FOB), locomotor activity, and neuropathology. 

2. STUDY DESIGN

Male and female Crl:CD(SD) rats were exposed to filtered air or one of the four 

concentrations of test substance vapor as once daily 6-hour, whole-body exposures on a 

5-day per week basis for 4 consecutive weeks. The following table represents the study 

group arrangement for both Phase I (Toxicology Phase) and Phase II (Neurotoxicity 

Phase). 

Toxicology Phase (Phase I)

Group 

Number Test Substance

Target Exposure 

Level (ppm)

Number of Animals

Males Females

1 Filtered air 0 5 5

2 ASAHIKLIN AE-3000 1000 5 5

3 ASAHIKLIN AE-3000 1500 5 5

4 ASAHIKLIN AE-3000 2000 5 5

5 ASAHIKLIN AE-3000 2500 5 5

Neurotoxicity Phase (Phase II)

Group 

Number Test Substance

Target Exposure 

Level (ppm)

Number of Animals

Males Females

1 Filtered air 0 10 10

2 ASAHIKLIN AE-3000 1000 10 10

3 ASAHIKLIN AE-3000 1500 10 10

4 ASAHIKLIN AE-3000 2000 10 10

5 ASAHIKLIN AE-3000 2500 10 10

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The total number of exposures prior to necropsy for Phase I animals was 20, and for the 

Phase II animals the total number of exposures was 19 to 23 for replicates 1 through 5, 

respectively. 

3. METHODS

3.1. EXPOSURE METHODS:

Exposures were conducted in 1000-L stainless-steel and glass whole-body exposure 

chambers. The exposure systems were operated under dynamic conditions from a 

HEPA- and charcoal-filtered air source or breathing quality in-house compressed air 

source. Air flow rate through the chamber was such that there were 12-15 air changes 

per hour. Mean chamber temperature and relative humidity were 22 ± 2°C and 30-70%, 

respectively. These parameters were monitored continuously and recorded 

approximately every 30-40 minutes throughout the exposure. Readings outside the 

average range were documented. Oxygen content of the exposure atmosphere was 

measured during the method development phase of the study, while operating at the 

above-targeted conditions, and was at least 19%. 

All animals were housed in a normal animal colony room during non-exposure hours. 

)RUHDFKGD\¶VH[posure, the animals were placed in exposure batteries, transported to the 

exposure room, exposed for the requisite duration, and returned to their home cages. 

Food and water were not available during the exposures. 

3.2. GENERAL TOXICOLOGY PHASE ± PHASE I

3.2.1. CLINICAL PATHOLOGY

Hematology and serum chemistry parameters were evaluated from all animals on the day 

of the scheduled necropsy. Animals were fasted overnight prior to blood collection. 

Blood was collected for hematology and serum chemistry evaluation via the retro-orbital 

sinus of animals anesthetized by inhalation of isoflurane. Blood was collected for 

coagulation parameters at the time of euthanasia via the vena cava of animals 

anesthetized by inhalation of isofluorane. Anticoagulants were potassium EDTA for the 

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hematology parameters and sodium citrate for the coagulation parameters. 

Anticoagulants were not used for serum chemistry samples.

The following parameters were evaluated.

3.2.1.1. HEMATOLOGY AND COAGULATION

Total leukocyte count (White Cells)

Erythrocyte count (Red Cells)

Hemoglobin

Hematocrit

Mean corpuscular volume (MCV)

Mean corpuscular hemoglobin 

(MCH)

Mean corpuscular hemoglobin 

concentration (MCHC)

Platelet count (Platelet)

Prothrombin time (ProTime)

Activated partial thromboplastin time 

(APTT)

Reticulocyte count

Percent (Reticulocyte)

Absolute (Retic Absolute)

Differential leukocyte count -

Percent and absolute

-Neutrophil

-Lymphocyte

-Monocyte

-Eosinophil

-Basophil

-Large unstained cell

Platelet estimate a

Red cell morphology 

(RBC Morphology) a

Red cell distribution width 

(Red Cell Width)

Hemoglobin distribution width

(HGB Width)

( ) - Designates tabular abbreviation

a - Presented on individual tables if a manual differential was performed, and the 

manual data were accepted and reported instead of the automated differential 

data

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3.2.1.2. SERUM CHEMISTRY

Albumin

Total protein

Globulin [by calculation]

Albumin/globulin ratio (A/G Ratio) 

[by calculation]

Total bilirubin (Total Bili)

Urea nitrogen

Creatinine

Alkaline phosphatase 

$ONDOLQH3KRV¶WVH

Alanine aminotransferase 

(Alanine Transfer)

Aspartate aminotransferase 

(AspartatTransfer)

Gamma glutamyltransferase 

(GlutamylTransfer)

Glucose

Total cholesterol (Cholesterol)

Calcium

Chloride

Phosphorus

Potassium

Sodium

Triglycerides (Triglyceride)

Sorbitol dehydrogenase 

6RUELWRO¶*HQDVH a

( ) - Designates tabular abbreviation

a - Presented in the special chemistry table

3.2.2. ANATOMIC PATHOLOGY

3.2.2.1. MACROSCOPIC EXAMINATION

Complete postmortem examinations were performed on all animals at the scheduled 

necropsy. Animals at the scheduled necropsy were anesthetized with isoflurane and 

exsanguinated. At the time of necropsy, the following tissues and organs were collected 

and placed in 10% neutral-buffered formalin fixative unless otherwise noted:

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Adrenal glands (2)

Aorta

Bone with marrow (sternebrae)

Bone with marrow (femur with 

joint)

Bone marrow smear (taken from 

femur) a

Brain

Cerebrum (2 levels)

Cerebellum with pons/medulla

Cervix

Epididymides (2) b

Eyes with optic nerves (2) c

Gastrointestinal tract

Esophagus

Stomach

Duodenum

Jejunum

Ileum

Cecum

Colon

Rectum

Harderian glands (2)

Heart 

Kidneys (2)

Lacrimal glands [exorbital (2)]

Larynx

Liver (sections of 2 lobes)

Lungs (including bronchi, fixed by 

inflation with fixative)

Lymph node

Axillary (2)

Mediastinal and bronchial (if visible)

Mesenteric and mandibular (2)

Nasal cavity d

Ovaries/oviducts (2) e

Pancreas

Peripheral nerve (sciatic)

3H\HU¶VSDWFKHV

Pharynx

Pituitary

Prostate

Salivary glands [mandibular (2)]

Seminal vesicles (2)

Skeletal muscle (rectus femoris)

Skin with mammary gland f

Spinal cord (cervical, thoracic, lumbar)

Spleen

Testes (2) b

Thymus

Thyroid gland [with parathyroids (2)] e

Trachea

Urinary bladder

Uterus 

Vagina

Gross lesions (when possible)

a - Bone marrow smears were obtained at the scheduled necropsy, but not placed 

in formalin; slides were not examined.

b - )L[HGLQ%RXLQ¶VVROXWLRQ c - )L[HGLQ'DYLGVRQ¶VVROXWLRQ

d - Following collection of the appropriate protocol-specified tissues, the entire 

head was removed and preserved. Following decalcification, 6 cross-sections 

of the nasal cavities were prepared for microscopic examination in accordance 

with the method described by Morgan (1991). e - Parathyroids and oviducts were examined microscopically if in the plane of 

section and in all cases when a gross lesion of the organ was present.

f - For females; a corresponding section of the skin was collected from the same 

anatomic area for males.

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3.2.3. ORGAN WEIGHTS

The following organs were weighed from all animals at the scheduled necropsy:

Adrenal glands

Brain

Epididymides

Heart

Kidneys

Liver

Lungs (prior to inflation with fixative)

Ovaries/oviducts

Spleen

Testes

Thyroid gland with parathyroids

Thyroid gland was fixed prior to weighing. Paired organs were weighed together. 

Organ-to-final-body-weight and organ-to-brain-weight ratios were calculated.

3.2.4. MICROSCOPIC EXAMINATION

Microscopic examination of routinely prepared hematoxylin-eosin stained paraffin 

sections was performed on all tissues (except brain) collected at necropsy from all 

animals in the control and 2500 ppm groups, with exceptions as indicated on the tissue 

list above. The lungs, liver, kidneys, and all gross lesions were examined from all 

animals in the low- and mid-level groups. Stained histologic sections were examined by 

light microscopy and observations were entered in the WIL Toxicology Data 

Management System (WTDMSE\WKHSDWKRORJLVW All gross necropsy observations 

were addressed. Histologic sections were of adequate size and quality for detailed 

evaluation. The number of missing tissues was negligible and did not interfere with 

detection of test substance-related histologic alterations in the study. Histopathologic 

lesions were classified using standard published terminology to the extent possible. The 

:7'06KLVWRSDWKRORJ\WDEOHVFRQWDLQDll of the recorded data and serve as the basis 

for this narrative report. 

3.3. NEUROPATHOLOGY ± PHASE II

3.3.1. ANATOMIC PATHOLOGY

3.3.1.1. MACROSCOPIC EXAMINATION

On the day following the final exposure, all surviving animals assigned to Phase II were 

prepared for neuropathological evaluation. All animals were deeply anesthetized by an 

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intraperitoneal injection of sodium pentobarbital and perfused in situ as described in 

WIL Standard Operating Procedures No. T3-034, as revised. Brain weight (including the 

olfactory bulbs) and size [length (excluding olfactory bulbs) and width] were recorded. 

Any abnormal coloration or lesions of the brain and spinal cord were recorded. Necropsy 

was conducted on the animals that were found dead or euthanized in extremis and the

tissues were collected and fixed with documentation of macroscopic findings. Tissues

with gross lesions were retained with fixation as described in Section 3.2.2.1. Animals

euthanized in extremis were anesthetized with isoflurane and exsanguinated. 

3.3.1.2. MICROSCOPIC EXAMINATION

Of the surviving animals assigned to Phase II and perfused in situ, 6 animals/sex/group 

were randomly selected for microscopic neuropathological evaluation. The following 

tissues were sampled:

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Brain ± sectioned at 8 levels to include the olfactory bulbs, cerebral cortex, 

hippocampus, basal ganglia, thalamus, hypothalamus, midbrain, 

cerebellum, pons and medulla oblongata.

Spinal cord ± at cervical swellings C3-C7 and at lumbar swellings T13-L4.

Trigeminal ganglia/nerves. a

Lumbar dorsal root ganglia at T13-L4. *

Lumbar dorsal root fibers at T13-L4. *

Lumbar ventral root fibers at T13-L4. *

Cervical dorsal root ganglia at C3-C7. *

Cervical dorsal root fibers at C3-C7. *

Cervical ventral root fibers at C3-C7. *

Sciatic nerves (mid-thigh region). (2)+

Sciatic nerves (at sciatic notch). (2) +

Sural nerves. (2) +

Tibial nerves. (2) +

Peroneal nerves.(2)+

Optic nerves. a

Eyes. a

Skeletal muscle ± gastrocnemius.

Other sites ± if deemed necessary.

a - Both processed and evaluated microscopically. * - 4-6 tissues were collected at necropsy; 2 were evaluated microscopically. + - One processed for microscopic examination.

(2) - Indicates that 2 sections (1 cross and 1 longitudinal) of the tissues were evaluated 

from the right hind leg. The tissues from the left hind leg were collected and 

preserved for possible future evaluation.

The central nervous system tissues listed above were prepared for a qualitative 

histopathological examination by embedding in paraffin, sectioning and staining with 

hematoxylin and eosin. The peripheral nervous system tissues listed above were 

prepared for a qualitative examination by embedding in plastic, sectioning, and staining 

using methodology deemed appropriate by the pathologist. Only tissues from the control 

and 2500 ppm groups were evaluated microscopically.

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3.4. ABBREVIATIONS

The following abbreviations may apply to this report:

Interval - point in the study at which event occurred (specimen collection, 

necropsy, etc.)

FD - found dead

EE - euthanized in extremis

SN - scheduled necropsy 

3.5. DATA INTERPRETATION

In the discussion of clinical pathology parameters, values derived from the control group 

animals were considered as concurrent control values for purposes of constructing a 

μQRUPDO¶ UDQJH IRU WKH SUHVHQW VWXG\  ,Q DGGLWLRQ KLVWRULFDO FRQWURO YDOXHV for this 

laboratory were consulted to refine data interpretation. Unless otherwise stated in this 

UHSRUW WKH μQRUPDO¶ KLVWRULFDO FRQWURO UDQJH ZDV UHSUHVHQWHG E\ YDlues within the 

WIL Historical Control reference range (the central 95% values).

In the discussion of organ weight differences, the indication of higher or lower mean 

RUJDQZHLJKWVUHIHUVWRDVWDWLVWLFDOO\VLJQLILFDQWSRUSXVLQJ'XQQHWW¶VWHVW

difference between test substance-treated versus control group animals in the present 

study. In addition, historical control values for this laboratory were consulted to refine 

data interpretation. 

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4. RESULTS FOR PHASE I

4.1. SURVIVAL

All Phase I animals survived to their scheduled necropsy.

4.2. CLINICAL PATHOLOGY

4.2.1. HEMATOLOGY AND COAGULATION

There were no test substance-related alterations in hematology and coagulation 

parameters. 

4.2.2. SERUM CHEMISTRY

There were no test substance-related alterations in serum chemistry parameters.

4.3. GROSS OBSERVATIONS

Review of the gross necropsy observations revealed no observations that were considered

to be associated with exposure to the test substance.

4.4. ORGAN WEIGHTS

There were no test substance-related alterations in final body weight or organ weights. 

The mean liver weight relative to final body weight for the 2500 ppm group females was 

12.3% higher than the control group females as a consequence of the mean final body 

weight in this group being 10.7% lower than the control group females.

The 2000 ppm and 2500 ppm female mean absolute spleen weights and mean spleen

relative to brain weights were approximately 23% lower than for the control group 

females; however, all individual animal values for these dosed groups were within the 

WIL Historical Control Data range for this age and strain of rat (Version 2.8). The 

absolute spleen weight for 1 control group female was above the upper limit (mean + 2 

standard deviations of the mean) of the historical control data for 9-12 week old rats and 

the spleen weight relative to brain weight of a different control female was above the 

historical range upper limit, contributing in part to the statistical differences between the 

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group means. These alterations were not considered evidence of a specific test 

substance-related effect.

4.5. HISTOLOGIC CHANGES

There were no test substance-related histologic changes noted. In males exposed to 

2500 ppm, a low incidence of focal neutrophil infiltrates and squamous metaplasia was

noted in nasal level I, with none being observed in the control group males. In the 

control group females, similar changes were evident, with none being noted in the 

2500 ppm group females. Consequently, these alterations were not considered evidence 

of a specific test substance-related effect.

5. RESULTS FOR PHASE II

5.1. SURVIVAL

Male no. 3770 (2000 ppm) was found dead on study day 22 with dark red areas noted in 

the glandular stomach. Female no. 3742 (2500 ppm) was euthanized in extremis on study 

day 25 with no macroscopic findings. No histologic evaluations were conducted and the 

causes of death were not determined for these two animals.

5.2. BRAIN WEIGHTS AND MEASURES

No test substance-related or statistically significant differences between groups were 

evident.

5.3. HISTOLOGIC CHANGES

No test substance-related histologic changes were noted.

6. CONCLUSIONS

This study was designed to evaluate the potential toxic and neurotoxic effects of 

administering the test substance by whole-body inhalation to Sprague-Dawley rats for 

6 hours each day, 5 days per week for 4 weeks at exposures of 0, 1000, 1500, 2000, and 

2500 ppm.

No test substance-related effects were evident in this study.

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    ! " #

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STUDY TITLE

A POSITIVE CONTROL VALIDATION STUDY

OF LOCOMOTOR ACTIVITY IN RATS

STUDY NUMBER

WIL-99435

STUDY DIRECTOR

Melissa J. Beck, PhD

STUDY INITIATION DATE

1 October 2007

STUDY COMPLETION DATE

3 June 2008

PERFORMING LABORATORY

WIL Research Laboratories, LLC

1407 George Road

Ashland, OH 44805-8946

-1-

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WIL-99435

STATEMENT OF NO DATA CONFIDENTIALITY CLAIMS

The purpose of the study was to validate the use of the Kinder Scientific MotorMonitor

System in our laboratory and to demonstrate the ability to detect decreases in locomotor

activity using this system. Therefore, this page has been intentionally left blank.

-2-

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WIL-99435

1. ABSTRACT

The objective of this study was to demonstrate the ability of the Kinder Scientific

MotorMonitor System (Kinder Scientific, LLC, Poway, CA, USA) to detect decreases in

activity in response to haloperidol within the U.S. EPA OPPTS Guideline 870.6300

(Developmental Neurotoxicity) and the International Conference on Harmonization

(ICH) Guideline 4.1.2 (Pre- and Postnatal Development, Including Maternal Function).

Haloperidol was administered at dosage levels of 0.05, 0.1, and 0.5 mg/kg by a single

intraperitoneal injection 30 minutes prior to behavioral testing on postnatal day (PND)

13, 17, 21 or 61. Male and female Sprague-Dawley Crl:CD (SD) rats were used for

assessment of locomotor behavior with the Kinder Scientific Motor Monitor System.

Overall, haloperidol caused a dose-dependent decrease in locomotor activity (total

activity counts and ambulatory counts) for both male and female rats at PND 13, 17, 21

and 61. Habituation was noted in PND 17, 21, and 61, but not in PND 13, males and

females. The experimental design used in this study demonstrated that WIL Research

Laboratories, LLC can detect locomotor effects of haloperidol using the Kinder Scientific

Motor Monitor System, and that the results can be considered to validate methodologies

for OPPTS Guideline 870.6300 developmental neurotoxicity studies and ICH Guideline

4.1.2 pre- and postnatal development studies.

-3-

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2. INTRODUCTION

The U.S. EPA guidelines (OPPTS 870.6300) for developmental neurotoxicity studies

indicate that locomotor activity testing should be performed on postnatal day (PND) 13,

17, 21 and 60 (± 2 days). Both the OPPTS 870.6300 and ICH 4.1.2 guidelines require

that neurobehavioral endpoints such as motor behavior be included with standard

toxicological indices. Validation of laboratory methodologies and demonstration of the

sensitivity of the equipment to detect test article-related changes are requirements of

these guidelines. WIL Research Laboratories, LLC chose to evaluate the use of the

Kinder Scientific MotorMonitor System to measure locomotor behavior in control and

test article-treated animals using haloperidol, which is a potent neuroleptic known to

decrease locomotor behavior.In rodent models used in behavioral assessment of motor

behavior, haloperidol impairs motor activity, decreases startle responsiveness and often

induces catalepsy (Fowler and Senvus, 1993; Patacchioli et al., 1996; Swerdlow et al.,

1998; Tada et al., 2004; Ballard et al., 2007). Specifically, at 0.1 mg/kg (s.c.),

haloperidol was able to decrease the startle magnitude in rats following acoustic

stimulation (Swerdlow et al. 1998). Regarding generalized motor behavior during open

field assessments, haloperidol at 0.05 mg/kg (i.p.) decreased activity counts, distance

traveled, and overall velocity (van den Buuse, 2003). For physically demanding

performance tasks, haloperidol at 0.16 and 0.32 mg/kg decreased the overall locomotor

speed of the rat during testing, while a dose as low as 0.04 mg/kg caused impaired task

performance (Fowler and Senyuz, 1993). Further behavioral measurements by

Patacchioli et al. (1996) showed that haloperidol at 0.5 mg/kg (i.p.) when given to

stimulated rats increased catalepsy time, while decreasing ambulations, rears, locomotor

starts, and overall activity. These findings were supported in methamphetaminestimulated rats where haloperidol induced catalepsy and decreased locomotion at dosages

ranging from 0.032 to 0.32 mg/kg (Tada et al., 2004).

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3. MATERIALS AND METHODS

3.1. TEST SPECIES AND HUSBANDRY

Sprague-Dawley Crl:CD(SD) rats were obtained from Charles River Laboratories, Inc.

(Raleigh, NC, USA). Twenty females with litters (5 pups/sex) were ordered to provide

20 rats/sex/group for testing on PND 13, 17 and 21. The breeder females were

individually housed in plastic maternity cages with nesting material (Bed-O’Cobs®). The

dams and pups remained in these cages until euthanasia on lactation day/PND 21. For

the PND 61 group, 80 rats/sex for motor assessment. The animals were housed 2-3/cage

(by sex) for 1 week, then individually in suspended wire mesh cages until euthanasia.

Environmental controls were set to maintain temperature at 71 ± 5o F and relative

humidity between 30–70%. Air handling units provided a minimum of 10 fresh air

changes per hour. Fluorescent lighting, controlled by timers, provided illumination for a

12-hour (6:00 a.m. – 6:00 p.m.) light/dark photoperiod. Temperature and relative

humidity were monitored continuously. Reverse osmosis-purified water and PMI

Nutrition International, LLC Certified Rodent LabDiet® 5002 were offered ad libitum

during the course of the study.

3.2. TEST MATERIAL AND PREPARATION

Haloperidol was purchased from Sigma Aldrich, Inc., St.Louis, MO, USA. An

appropriate amount of haloperidol was mixed with the vehicle (1% lactic acid) to produce

dosing levels of 0.05, 0.1 and 0.5 mg/kg of body weight with a corresponding dosage

volume of 10 mL/kg (for PND 13, 17 and 21 neonates) and 1 mL/kg (for PND 61 young

adults) Dosing solutions, including the vehicle for administration to the control group,

were prepared on each day of dose administration.

3.3. EXPERIMENTAL DESIGN

For the neonatal phase, four groups of 20 rats/sex received an intraperitoneal injection of

0, 0.05, 0.1 or 0.5 mg/kg haloperidol on PND 13, 17 and 21. For the young adult phase,

the same dosages of haloperidol were administered to four groups of 20 rats/sex on

PND 61. At all four ages, the haloperidol was administered 30 minutes prior to

assessment of locomotor behavior. All rats were observed twice daily for moribundity

and mortality, once in the morning and once in the afternoon until euthanasia. Body

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weight and clinical observations were recorded on each day of dose administration. The

observations included, but were not limited to, evaluations for changes in appearance of

skin and fur, eyes, mucous membranes, respiratory and circulatory systems, autonomic

and central nervous systems, somatomotor activity and behavior. Additional

observations, if needed, were documented in the study records. The following table

summarizes the testing paradigm:

Neonatal Phase (Postnatal Day 13, 17 and 21)

Group

Number Test Article

Dosage Level

(mg/kg)

Number of

Malesa

Number of

Femalesa

1 Vehicle Control 0 20 20

2 Haloperidol 0.05 20 20

3 Haloperidol 0.1 20 20

4 Haloperidol 0.5 20 20

a - Animals used for neonatal phase assessments were selected from 20 litters for

PND 13, 17 and 21 testing, such that 1 rat/sex/litter was assigned to each group.

Young Adult Phase (Postnatal Day 61)

Group

Number Test Article

Dosage Level

(mg/kg)

Number of

Males

Number of

Females

1 Vehicle Control 0 20 20

2 Haloperidol 0.05 20 20

3 Haloperidol 0.1 20 20

4 Haloperidol 0.5 20 20

3.4. BEHAVIORAL TESTING

Twenty neonatal animals/sex/group were assigned to the locomotor activity tests

performed on PND 13, 17, 21, and 20 young adult animals/sex/group were assigned to

the locomotor activity test performed on PND 61 using the automated Kinder Scientific

MotorMonitor System (Kinder Scientific, LLC, Poway, CA, USA). The test session was

in a sound-attenuated room and was 60 minutes in duration, consisting of 6 subintervals

lasting 10 minutes each. Locomotor activity was evaluated as total and ambulatory

activity counts obtained over each subinterval (0-10 minutes, 11-20 minutes, 21-30

minutes, 31-40 minutes, 41-50 minutes and 51-60 minutes) and the entire 60-minute

session.

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3.5. STATISTICAL ANALYSIS

All analyses were two-tailed for minimum significance levels of 5% and 1%. All

statistical tests were performed by a computer with appropriate programming as

referenced below. Total and ambulatory locomotor activity counts were analyzed, by sex

and session, with a repeated measure analysis of variance (RANOVA). Factors in the

model included treatment group (TRT), time interval (TIME), and the interaction of time

interval and treatment group (TRT*TIME). The SAS® procedure PROC MIXED was

used for analysis with the random effect of animal included as the repeated measurement.

The covariance structure across time was selected by comparing Akaike's Information

Criterion.

The monotonic dose-response relationship was evaluated using sequential linear trend

tests based on ordinal spacing of dose levels. The linear dose by time interaction was

evaluated and, if significant at the 0.05 level, trend tests on treatment means were

performed at the 0.05 level for each time interval. If the linear dose by time interaction

was not significant, the trend test was conducted across the pooled time intervals of the

entire session only.

Nonmonotonic dose responses were evaluated whenever no significant linear trends were

detected but TRT and/or TRT*TIME interaction was significant at the 0.01 level. Within

the framework of the RANOVA, pairwise comparisons were made for each individual

test article-treated group with the control group through linear contrasts. If TRT*TIME

was significant, the comparisons were conducted for each time interval. If only the TRT

effect was significant, the comparisons were conducted across the pooled time intervals

of the entire session. These nonmonotonic dose-response comparisons were conducted at

the 0.01 significance level.

All statistical analyses were conducted by BioSTAT Consultants, Inc., Portage, MI, USA,

using SAS Version 8.2 (SAS Institute, Inc., 1999-2001) software.

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4. RESULTS AND DISCUSSION

A normal ontogenic profile of activity in control animals was demonstrated by the Kinder

Scientific MotorMonitor System when examining both the mean total and mean

ambulatory activity counts from PND 13, 17, and 21 males (Figures 1A and 2A). This

trend, however, was not present in females (Figures 1B and 2B) because of the elevated

level of activity in the PND 13 control females. Specifically, the PND 13 vehicle control

males tended to be less active than the PND 17 males in the same group, with activity

decreasing on PND 21. This is consistent with the development of motor behavior in a

novel environment, where activity is relatively low in PND 13 neonatal rats, increases

around PND 17 and then decreases around PND 21. Total activity counts measured in

each subinterval by the Kinder Scientific MotorMonitor in PND 13 haloperidol treatment

groups (Figure 3A and B) shows a decreased motor activity for males (0.5 mg/kg) and

females (0.05, 0.1, and 0.5 mg/kg). This same haloperidol effect was also present in

ambulatory activity counts over the subintervals (Figure 4A and B), where ambulatory

activity was decreased in males (0.5 mg/kg) and females (0.05, 0.1, and 0.5 mg/kg).

When examining the mean total and ambulatory activity taken over all subintervals

(Figure 1A and B, Figure 2A and B), there was also an indication that the PND 13

females showed a dose-dependent decrease in activity for each haloperidol treatment,

whereas PND 13 males only showed decreased motor activity at 0.5 mg/kg. In the PND

13 males, the lower haloperidol doses (0.05 and 0.1 mg/kg) did not consistently decrease

motor activity. Although the decreased motor activity following haloperidol treatment

was attenuated in males, the decreased total and ambulatory activity counts are consistent

with previously published studies indicating that haloperidol decreases overall motor

activity (Fowler and Senyuz, 1993; Patacchioli et al., 1996; Swerdlow et al., 1998; Tada

et al., 2004; Ballard et al., 2007).

The total activity counts across individual subintervals measured in PND 17 males and

females (Figure 5A and B) showed a more robust dose-dependent decrease than in the

PND 13 haloperidol treatment groups (0.05, 0.1, and 0.5 mg/kg). In a similar manner, the

PND 17 male and female (Figure 6A and B) ambulatory activity counts followed the

same dose-dependent trend following haloperidol treatment at 0.05, 0.1, and 0.5 mg/kg.

For both total and ambulatory activity, the presence of a dose-dependent decrease in the

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PND 17 males was partially the result of the relatively large increase (approximately 3-

fold) in the baseline (vehicle control) activity compared to the vehicle control group on

PND 13. In addition, there was the presence of habituation over the course of the

behavioral assessment in the vehicle control males and females on PND 17. When

examining the mean total and ambulatory activity taken over all subintervals (Figure 1A

and B, Figure 2A and B), there was also an indication that the PND 17 males and females

showed the same dose-dependent decrease in activity with haloperidol treatment. This is

consistent with the effects of various doses of haloperidol (0.03 mg/kg to 0.5 mg/kg)

decreasing overall and ambulatory activity, while increasing catalepsy in male and female

rats (Fowler and Senyuz, 1993; Patacchioli et al., 1996; Swerdlow et al., 1998; Tada et

al., 2004; Ballard et al., 2007).

This effect of haloperidol decreasing total activity counts over the six subintervals was

also present in the PND 21 male and female 0.1 and 0.5 mg/kg treatment groups

(Figure 7A and B). Ambulatory activity taken over the six subintervals also decreased in

a dose-dependent manner for both males and females (Figure 8A and B). In the PND 21

males and females, habituation to the environment was present in controls, as well as in

the 0.01, 0.1, 0.5 mg/kg haloperidol treatment groups, although the habituation profile

was difficult to evaluate for males and females in the 0.5 mg/kg group. The decreased

motor behavior (total and ambulatory activity counts) was similar to the overall trend

noted in PND 17 males and females, as well as the effect of haloperidol decreasing motor

activity indicated in the literature. This is also consistent with the effects of various doses

of haloperidol (0.03 mg/kg to 0.5 mg/kg) decreasing overall and ambulatory activity,

while increasing catalepsy in male and female rats (Fowler and Senyuz, 1993; Patacchioli

et al., 1996; Swerdlow et al., 1998; Tada et al., 2004; Ballard et al., 2007).

In general for the PND 13 males and females, habituation did not occur over the course

of assessment for both total and ambulatory activity (Figure 3A and B, Figure 4A and B).

There was also an apparent gender effect in both total and ambulatory activity counts

taken over the individual subinterval or over the entire assessment period suggesting that

females are more sensitive to haloperidol treatment than males. This apparently

attenuated effect, however, is likely due to elevated baseline (vehicle control) activity

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measurements in females compared to males at PND 13. As previously noted, the PND

13 rats did not have an habituation profile, whereas this profile became present in the

PND 17 and 21 rats (Figures 5 through 8). This indicates that the Kinder Scientific

MotorMonitor System was able to detect the development of activity for PND 13, 17 and

21 males and females.

Haloperidol treatment of male and female PND 61 young adults (Figure 10A and B)

identified a decrease in total activity over the course of the six subintervals only at the

two higher doses (0.1 and 0.5 mg/kg). This same dose effect of 0.1 and 0.5 mg/kg

haloperidol was also present in the ambulatory activity data over all subintervals (Figure

11A and B). Although habituation was present in the control and haloperidol treatments

(0.05, 0.1, and 0.5 mg/kg), the 0.5 mg/kg profile was attenuated. Since trend of

habituation was specific within all PND 61 rats, this was likely indicative of a decreased

sensitivity in the young adult rats (or increased sensitivity in younger rats). This was also

apparent in the mean total and ambulatory activity counts for the entire testing session

(Figure 9A and B) where only the 0.1 mg/kg and 0.5 mg/kg doses substantially decreased

activity. However, haloperidol still decreased motor activity (total and ambulatory

activity counts) in both males and females, which is consistent with the previously

examined ages in this study and with the published literature (Fowler and Senyuz, 1993;

Patacchioli et al., 1996; Swerdlow et al., 1998; Tada et al., 2004; Ballard et al., 2007).

In conclusion, the motor activity data (i.e. total activity and ambulatory activity) for

Sprague Dawley Crl:CD (SD) rats generated by the Kinder Scientific MotorMonitor

System are consistent with the effects of haloperidol on motor behavior. This motor

monitoring system is therefore capable and sensitive enough to measure reductions in

motor activity in neonatal and young adult rodents with a positive control agent such as

haloperidol.

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5. REFERENCES

Ballard, M.E.; Basso A.M.; Gallagher, K.B.; Brownman, K.E.; Fox G.B.; Drescher,

K.U.; Gross, G.; Decker, M.W.; Rueter, L.E.; Zhang, M. The drug-induced

helplessness test: an animal assay for assessing behavioral despair in response to

neuroleptic treatment. Psychopharmacology 2007, 190, 1-11.

Fowler, S.C.; Senyuz, L. Effects of haloperidol on a run-climb-run behavioral task:

distance climbed does not alter within-session decrements. Behavioral Neuroscience

1993, 107, 651-661.

Patacchioli, F.R.; Di Grezia, R.; Angelucci, L. Arginine-aspartate and haloperidolinduced neurobehavioral effects in the rat. European Journal of Pharmacology

1996, 299, 29-32.

SAS® Proprietary Software, Version 8.2; SAS Institute, Inc.: Cary, NC, 1999-2001.

Swerdlow, N.R.; Bakshi, V.; Waikar, M.; Taaid, N.; Geyer, M.A. Seroquel,

clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats.

Psychopharmacology, 1998 140, 75-80.

Tada, M.; Shirakawa, K.; Matsuoka, N.; Mutoh, S. Combined treatment of

quetiapine with haloperidol in animal models of antipsychotic effect and

extrapyramidal side effects: comparison with risperidone and chlorpromazine.

Psychopharmacology 2004, 176, 94-100.

van den Buuse, M. Acute effects of antipsychotic drugs on cardiovascular responses

to stress. European Journal of Pharmacology 2003 464, 55-62.

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FIGURES 1 - 11

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Mean Total Activity Counts For Males By PND

Postnatal Day

PND 13 PND 17 PND 21

Activty Counts (# beam breaks)

0

500

1000

1500

2000

2500 Vehicle Control

Haloperidol 0.05 mg/kg 

Haloperidol 0.1 mg/kg 

Haloperidol 0.5 mg/kg 

A

*

***

***

 

Mean Total Activity Counts For Females By PND

Postnatal Day

PND 13 PND 17 PND 21

Activity Counts (# beam breaks)

0

500

1000

1500

2000

B 2500

** 

*

***

***

*

***

***

Figure 1: Mean total activity counts for (A) male and (B) female PND 13, 17 and 21

neonates, expressed as mean ± SEM. Significance between the treatment

and vehicle control group is indicated by *

p<0.05, **p<0.01 and ***p<0.001.

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Mean Total Ambulatory Activity Counts For Males By PND

Postnatal Day

PND 13 PND 17 PND 21

Activty Counts (# beam breaks)

0

200

400

600

800

1000

Vehicle Control

Haloperidol 0.05 mg/kg 

Haloperidol 0.1 mg/kg 

Haloperidol 0.5 mg/kg 

A

*

**

***

*

***

Mean Total Ambulatory Activity Counts for Females by PND

Postnatal Day

PND 13 PND 17 PND 21

Activity Counts (# beam breaks)

0

200

400

600

800

1000

B

*

*

******

*

***

***

Figure 2: Mean total ambulatory activity counts (A) male and (B) female PND 13,

17 and 21 neonates, expressed as mean ± SEM. Significance between the

treatment and vehicle control group is indicated by *p<0.05, **p<0.01 and

***p<0.001.

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Total Activity Counts For PND 13 Males By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

50

100

150

200

250

300

350

400

450

500

550

Vehicle Control

Haloperidol 0.05 mg/kg

Haloperidol 0.1 mg/kg

Haloperidol 0.5 mg/kg

A

Total Activity Counts For PND 13 Females By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

50

100

150

200

250

300

350

400

450

500

550

B

Figure 3: Mean total activity counts for (A) male and (B) female PND 13 neonates

over each subinterval, expressed as mean ± SEM.

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Ambulatory Acitivty Counts For PND 13 Males By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

50

100

250

300

Vehicle Control

Haloperidol 0.05 mg/kg

Haloperidol 0.1 mg/kg

Haloperidol 0.5 mg/kg

A

Ambulatory Activity Counts For PND 13 Females By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

50

100

150

200

250

300

B

Figure 4: Mean ambulatory activity counts for (A) male and (B) female PND 13

neonates over each subinterval, expressed as mean ± SEM.

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Total Activity Counts For PND 17 Males By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

100

200

300

400

500

600

700 Vehicle Control

Haloperidol 0.05 mg/kg

Haloperidol 0.1 mg/kg

Haloperidol 0.5 mg/kg

A

Total Activity Counts For PND 17 Females By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

100

200

600

700

B

Figure 5: Mean total activity counts for (A) male and (B) female PND 17 neonates

over each subinterval, expressed as mean ± SEM.

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Ambulatory Activity Counts For PND 17 Males By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

25

50

75

100

125

150

175

200

225 Vehicle Control

Haloperidol 0.05 mg/kg 

Haloperidol 0.1 mg/kg 

Haloperidol 0.5 mg/kg 

A

Ambulatory Activity Counts For PND 17 Females By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activitys Count (# beam breaks)

0

25

50

75

100

125

150

175

200

225

B

Figure 6: Mean ambulatory activity counts for (A) male and (B) female PND 17

neonates over each subinterval, expressed as mean ± SEM.

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Total Activity Counts For PND 21 Males By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

100

200

300

400

500

600

700

800

Vehicle Control

Haloperidol 0.05 mg/kg

Haloperidol 0.1 mg/kg

Haloperidol 0.5 mg/kg

A

Total Activity Counts For PND 21 Females By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks) 

0

100

200

300

400

500

600

700

B 800

Figure 7: Mean total activity counts for (A) male and (B) female PND 21 neonates

over each subinterval, expressed as mean ± SEM.

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Ambulatory Activity Counts For PND 21 Males By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

50

100

150

200

250

300

Vehicle Control

Haloperidol 0.05 mg/kg

Haloperidol 0.1 mg/kg

Haloperidol 0.5 mg/kg

A

Ambulatory Activity Counts For PND 21 Females By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

50

100

150

200

250

300

B

Figure 8: Mean ambulatory activity counts for (A) male and (B) female PND 21

neonates over each subinterval, expressed as mean ± SEM.

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Mean Total Activity Counts For PND 61 Males and Females

Male Female

Activity Counts (# beam breaks)

0

500

1000

1500

2000

2500

3000

Vehicle Control

Haloperidol 0.05 mg/kg 

Haloperidol 0.1 mg/kg 

Haloperidol 0.5 mg/kg 

A

*

*

***

***

***

Mean Total Ambulatory Counts for PND 61 Males and Females

Male Female

Activity Counts (# beam breaks)

0

100

200

300

400

500

600

700

B

***

***

***

***

Figure 9: Mean total activity and ambulatory activity counts for (A) male and (B)

female PND 61 young adults, expressed as mean ± SEM. Significance

between the treatment and vehicle control group is indicated by *p<0.05

and ***p<0.001.

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Total Activity Counts For PND 61 Males By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

200

400

600

800

1000

1200

1400

Vehicle Control

Haloperidol 0.05 mg/kg

Haloperidol 0.1 mg/kg

Haloperidol 0.5 mg/kg

A

Total Activity Counts For PND 61 Females By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

200

400

600

800

1000

1200

1400

B

Figure 10: Mean total activity counts for (A) male and (B) female PND 61 young

adults over each subinterval, expressed as mean ± SEM.

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Ambulatory Activity Counts For PND 61 Males By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

50

100

150

200

250

300

350

400

450

Vehicle Control

Haloperidol 0.05 mg/kg

Haloperidol 0.1 mg/kg

Haloperidol 0.5 mg/kg

A

Ambulatory Activity Counts For PND 61 Females By Subinterval

Subinterval (minutes)

0-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

50

100

150

200

250

300

350

400

450

B

Figure 11: Mean ambulatory activity counts for (A) male and (B) female PND 61

young adults over each subinterval, expressed as mean ± SEM.

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STUDY TITLE

A POSITIVE CONTROL VALIDATION

STUDY OF LOCOMOTOR ACTIVITY IN RATS

STUDY NUMBER

WIL-99441

STUDY DIRECTOR

Melissa J. Beck, PhD

STUDY INITIATION DATE

26 October 2007

STUDY COMPLETION DATE

27 May 2008

PERFORMING LABORATORY

WIL Research Laboratories, LLC

1407 George Road

Ashland, OH 44805-8946

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STATEMENT OF NO DATA CONFIDENTIALITY CLAIMS

The purpose of the study was to validate the use of the Kinder Scientific MotorMonitor

System in our laboratory and to demonstrate the ability to detect increases in locomotor

activity using this system. Therefore, this page has been intentionally left blank.

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1. ABSTRACT

The objective of this study was to demonstrate the ability of the Kinder Scientific

MotorMonitor System to detect increases in activity in response to nicotine and

amphetamine within the U.S. EPA OPPTS 870.6300 (Developmental Neurotoxicity),

OECD 426 (Developmental Neurotoxicity) and ICH 4.1.2 (Pre- and Postnatal

Development) guidelines. Nicotine and amphetamine were administered to male and

female Sprague-Dawley Crl:CD rats 3 and 15 minutes, respectively, prior to assessment

of locomotor behavior with the Kinder Scientific MotorMonitor System. Nicotine was

administered at a dosage level of 0.1 or 0.5 mg/kg by a single intraperitoneal injection to

neonatal rats on postnatal days (PND) 13, 17 and 21. Amphetamine was administered at

a dosage level of 1 or 3 mg/kg by a single intraperitoneal injection to young adult rats

(male and female) on PND 61 and at a dosage level of 0.2 or 1 mg/kg to young adult

PND 61 females. Nicotine caused an increase in locomotor activity (mean total and

ambulatory activity) in male and female neonatal rats at PND 13, 17 and 21. The

habituation profile was evident in the PND 17 and 21 males and females. In a similar

manner, amphetamine stimulated locomotor behavior in male and female rats at PND 61,

causing both total and ambulatory activity to increase. The subsequent female-only

groups (0.2 and 1 mg/kg amphetamine) exhibited a dose response with increased total

and ambulatory activity compared to controls. In the PND 61 males and females (given 1

or 3 mg/kg amphetamine), the habituation profile was only present in the control and

3 mg/kg amphetamine treatment groups, whereas the habituation profile was present in

the female-only PND 61 control and 0.2 mg/kg amphetamine groups. The experimental

design used in this study demonstrated that WIL Research can detect locomotor effects of

nicotine and amphetamine using the Kinder Scientific MotorMonitor System, and that the

results can be considered to validate methodologies for OPPTS 870.6300 and OECD 426

developmental neurotoxicity studies and ICH 4.1.2 pre- and postnatal development

studies.

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2. INTRODUCTION

The U.S. EPA Guideline OPPTS 870.6300 and OECD Guideline 426 for developmental

neurotoxicity studies indicate that locomotor activity testing should be performed on

postnatal (PND) 13, 17, 21 and 60 (± 2 days). The guidelines, and also ICH 4.1.2 require

that neurobehavioral endpoints such as motor behavior be included with standard

toxicological indices to support product registration under the Federal Insecticide,

Fungicide and Rodenticide Act (FIFRA) and the Toxic Substances Control Act (TSCA).

Validation of laboratory methodologies and demonstration of the sensitivity of the

equipment to detect test article-related changes are requirements of this guideline. WIL

Research Laboratories, LLC chose to evaluate the use of the Kinder Scientific

MotorMonitor System to measure locomotor behavior in control and test article-treated

animals using nicotine and amphetamine, which are known to increase indices of

locomotor behavior.

Both nicotine and amphetamine are widely used in the rodent animal model to measure

various behaviors, specifically involving motor function. Treatment of rodents with

nicotine increases motor function associated with the startle response (Gould et al., 2005;

Lewis and Gould, 2003; Acri et al., 1995). Specifically, acute treatment of nicotine (0.1

and 0.5 mg/kg, s.c.) stimulates overall motor activity in both male neonates and young

adults (Faraday et al., 2003). Interestingly, following delivery of nicotine to neonates,

they exhibited increases in movements and rearing behaviors; whereas, young adults did

not show these same levels (Faraday et al., 2003). This same stimulatory effect of

nicotine is also present in females treated with similar levels of nicotine (0.1 and

0.5 mg/kg, s.c.) under similar testing parameters (Elliot et al., 2005). Nicotine, however,

appears to be the most effective at increasing motor function in neonatal age ranges rather

in than in young adults (Domino et al., 2001; Bevins and Besheer, 2001; Shoaib and

Shippenberg, 1996).

Amphetamine at low concentrations (0.2, 0.4 and 0.8 mg/kg) increases overall locomotor

behavior in adult rats in a dose-dependent manner (Mobini et al., 2000). The same trend

is also present when compared to moderately higher doses of amphetamine (2 mg/kg),

which show significant dose-dependent increases in locomotor activity (Yates et al.,

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2007; Chatterjie et al., 1998). This noted effect of amphetamine increasing of horizontal

and vertical motor activity, total distance covered, and stereotypic behaviors for up to

2 hours post-treatment (Gaytan et al., 1996). Although still elevated when compared to

control animals, amphetamine at even higher doses (6, 10, 12, 16, and 20 mg/kg) actually

becomes less effective at increasing the distance covered and other general locomotorrelated behaviors (Yates et al., 2007).

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3. MATERIALS AND METHODS

3.1. TEST SPECIES AND HUSBANDRY

Sprague-Dawley Crl:CD(SD) rats were obtained from Charles River Laboratories, Inc.

(Raleigh, NC, USA). Twenty females with litters (5 pups/sex) were ordered to provide

20 rats/sex/group for testing on PND 13, 17 and 21. The breeder females were

individually housed in plastic maternity cages with nesting material (Bed-O’Cobs®). The

dams and pups remained in these cages until euthanasia on lactation day/PND 21. For

the PND 61 groups, 84 young adult rats/sex were ordered for startle response testing of

80 rats/sex. The animals were housed 2-3/cage (by sex) for 1 week, then individually in

suspended wire mesh cages until euthanasia.

 Environmental controls were set to maintain temperature at 71 ± 5o F and relative

humidity between 30–70%. Air handling units provided a minimum of 10 fresh air

changes per hour. Fluorescent lighting, controlled by timers, provided illumination for a

12-hour (6:00 a.m. – 6:00 p.m.) light/dark photoperiod. Temperature and relative

humidity were monitored continuously. Reverse osmosis-purified water and PMI

Nutrition International, Inc. Certified Rodent LabDiet® 5002 were offered ad libitum

during the course of the study.

3.2. TEST MATERIAL AND PREPARATION

(-)-Nicotine Hydrogen Tartrate Salt was purchased from Sigma Aldrich, St.Louis, MO,

USA. An appropriate amount of nicotine was mixed with the vehicle (0.9% sodium

chloride for injection) to produce dosing concentrations of 0.005 and 0.025 mg/mL with a

corresponding dosage volume of 20 mL/kg. Dosing solutions were prepared on each day

of dose administration.

D–Amphetamine Sulfate was purchased from Sigma Aldrich, St. Louis, MO. An

appropriate amount of amphetamine, corrected for salt content, was mixed with the

vehicle (0.9% sodium chloride for injection) to produce dosing concentrations of 0.2, 1

and 3 mg/mL with a corresponding dosage volume of 1 mL/kg. Dosing solutions were

prepared on each day of dose administration.

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On each day of dose administration, a sufficient amount of vehicle was dispensed for

administration to all control groups.

3.3. EXPERIMENTAL DESIGN

For the neonatal phase, four groups of 20 rats/sex received an intraperitoneal injection of

nicotine at 0, 0.1 or 0.5 mg/kg on PND 13, 17 and 21, approximately 3 minutes prior to

assessment of locomotor behavior. For the young adult phase, amphetamine was

administered by an intraperitoneal injection to four groups of 20 rats/sex at 0, 1 or

3 mg/kg on PND 61, approximately 15 minutes prior to assessment of locomotor

behavior. In addition, 3 separate groups of 20 female rats/group at 0, 0.2 or 1 mg/kg on

PND 61 were also administered amphetamine by intraperitoneal injection approximately

15 minutes prior to locomotor assessment. The corresponding dosage volumes were 20

mL/kg for nicotine and 1 mL/kg for amphetamine. All rats were observed twice daily for

moribundity and mortality, once in the morning and once in the afternoon until

euthanasia. Body weights and clinical observations were recorded on each day of dose

administration. The observations included, but were not limited to evaluations for

changes in appearance of skin and fur, eyes, mucous membranes, respiratory and

circulatory systems, autonomic and central nervous systems, somatomotor activity and

behavior. Additional observations, if needed, were documented in the study records.

The following table summarizes the testing paradigm:

Neonatal Phase (Postnatal Day 13, 17 and 21)

Group

Number Test Article

Dosage Level

(mg/kg)

Number of

Malesa

Number of

Femalesa

1 Vehicle Control 0 20 20

2 Vehicle Control 0 20 20

3 Nicotine 0.1 20 20

4 Nicotine 0.5 20 20

a- Animals used for neonatal phase assessments was selected from 20 litters for

PND 13, 17 and 21 testing, such that 1 rat/sex/litter was assigned to each group.

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Young Adult Phase (Postnatal Day 61)

Group

Number Test Article

Dosage Level

(mg/kg)

Number of

Males

Number of

Females

1 Vehicle Control 0 20 20

2 Vehicle Control 0 20 20

3 Amphetamine 1 20 20

4 Amphetamine 3 20 20

Young Adult Phase (Postnatal Day 61; Females Only)

Group

Number Test Article

Dosage Level

(mg/kg)

Number of

Females

1 Vehicle Control 0 20

2 Amphetamine 0.2 20

3 Amphetamine 1 20

3.4. BEHAVIORAL TESTING

Twenty neonatal animals/sex/group were assigned to the locomotor activity tests

performed on PND 13, 17 and 21, and 20 young adult animals/sex/group with an

additional 20 young adult females/group were assigned to the locomotor activity test

performed on PND 61 using the automated Kinder Scientific MotorMonitor System

(Kinder Scientific, LLC, Poway, CA, USA). The test session was 60 minutes in

duration, consisting of 6 subintervals lasting 10 minutes each. Locomotor activity was

evaluated as total and ambulatory activity counts obtained over each subinterval

(0-10 minutes, 11-20 minutes, 21-30 minutes, 31-40 minutes, 41-50 minutes and

51-60 minutes) and the entire 60-minute session.

3.5. STATISTICAL ANALYSIS

All analyses were two-tailed for minimum significance levels of 5% and 1%. All

statistical tests were performed by a computer with appropriate programming as

referenced below. Total and ambulatory counts were analyzed, by sex and session, with

a repeated measure analysis of variance (RANOVA). Factors in the model included

treatment group (TRT), time interval (TIME), and the interaction of time interval and

treatment group (TRT*TIME). The SAS® procedure PROC MIXED was used for

analysis with the random effect of animal included as the repeated measurement. The

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covariance structure across time was selected by comparing Akaike's Information

Criterion.

The monotonic dose-response relationship was evaluated using sequential linear trend

tests based on ordinal spacing of dose levels. The linear dose by time interaction was

evaluated and, if significant at the 0.05 level, trend tests on treatment means were

performed at the 0.05 level for each time interval. If the linear dose by time interaction

was not significant, the trend test was conducted across the pooled time intervals of the

entire session only.

Nonmonotonic dose responses were evaluated whenever no significant linear trends were

detected but TRT and/or TRT*TIME interaction was significant at the 0.01 level. Within

the framework of the RANOVA, pairwise comparisons were made for each individual

test article-treated group with the control group through linear contrasts. If TRT*TIME

was significant, the comparisons were conducted for each time interval. If only the TRT

effect was significant, the comparisons were conducted across the pooled time intervals

of the entire session. These nonmonotonic dose-response comparisons were conducted at

the 0.01 significance level.

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4. RESULTS AND DISCUSSION

The ontogenic profile of activity in control animals was demonstrated by the Kinder

Scientific MotorMonitor System when examining both the mean total and mean

ambulatory activity counts from PND 13, 17 and 21 males and females (Figure 1A and B,

Figure 2A and B). This behavioral profile of motor function is evident by the relatively

low activity in PND 13 neonates, followed by an increase in activity at PND 17 and then

a decrease in activity at PND 21. This is consistent with the development of motor

behavior in male and female neonates when exposed to a novel environment over these

three time points (PND 13, 17 and 21).

Total activity counts measured over each subinterval by the Kinder Scientific

MotorMonitor System in PND 13 male and female treatment groups (Figure 3A and B)

showed a slight tendency of nicotine to increase activity in males and females at

0.5 mg/kg. This effect was more evident in the ambulatory activity counts over

subinterval 1-10 (Figure 4A and B). For both total and ambulatory activity counts in the

PND 13 male and female high nicotine groups (0.5 mg/kg) there was a marked drop from

subinterval 1-10 to 11-20, after which there was no distinction between groups. This

initial elevation is the first sign in the development of an habituation profile, and also

supports the effect of nicotine increasing motor activity that has been documented in the

literature (Domino et al., 2001; Bevins and Besheer, 2001; Shoaib and Shippenberg,

1996).

The PND 17 male (0.1 and 0.5 mg/kg) and female (0.5 mg/kg) nicotine treatment groups

exhibited increased total and ambulatory locomotor behavior over all of the subintervals

(Figure 1A and B, Figure 2A and B). The apparent greater effect of nicotine in the

PND 17 males and females (compared to PND 13) may be due to the tendency of motor

behavior to increase in this age group. Examining each subinterval during behavioral

assessment indicated that the nicotine-treated males and females tended to be more active

(total and ambulatory) than the control groups over the initial 3 subintervals (Figure 5A

and B, Figure 6A and B). This increased level of motor activity is comparable to the

increased activity measurements at similar doses present in the literature (Shoaib and

Shippenberg, 1996; Bevins and Besheer, 2001; Faraday et al., 2003; Elliot et al., 2005).

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In addition, an habituation profile was present in each PND 17 male and female group

over the six subintervals.

The nicotine treatment effect, primarily at 0.5 mg/kg, also resulted in an increased mean

total and ambulatory activity in the PND 21 males and females (Figure 1A and B, Figure

2A and B). This effect of nicotine was apparently dose dependent for both males and

females, with the 0.5 mg/kg having the greatest level of activity. The effect of nicotine

on PND 21 motor activity was also more pronounced for the total and ambulatory activity

measurements taken over all six subintervals (Figure 7A and B, Figure 8A and B). In

addition, the development of the habituation profile was more evident in the PND 21

nicotine-treated males and females. Even in this age group (PND 21), the effects of

nicotine at 0.1 and 0.5 mg/kg are consistent with previously published behavioral

assessment research (Shoaib and Shippenberg, 1996; Bevins and Besheer, 2001; Faraday

et al., 2003; Elliot et al., 2005).

The use of the Kinder Scientific MotorMonitor System showed that amphetamine

treatment (1 and 3 mg/kg) increased PND 61 male and female mean total and ambulatory

activity counts (Figure 9A and B). This effect was not dose dependent, because the most

activity was present in the 1 mg/kg amphetamine male and female treatment groups.

However, addition of the amphetamine-treated (0.2 and 1 mg/kg) PND 61 females

indicated that there was a dose-dependent effect of amphetamine (Figure 12A and B) on

mean total and ambulatory activity counts. The 3 mg/kg amphetamine treatment in the

previously mentioned PND 61 males and females resulted in substantially lower level of

mean total activity than in the 1 mg/kg groups, although still above the control groups.

This same decrease in activity was also present in the mean ambulatory data suggesting

that generalized activity or movement (i.e., shaking) was not substituted with an increase

in ambulation. Reports in the literature do indicate that, although amphetamine acts to

increase motor activity, there is a point where amphetamine can become inhibitory in

nature depending on the strain, age, gender and testing paradigm used (Gaytan et al.,

1996; Mobini et al. 2000; Chatterjie et al., 1998; Yates et al., 2007).

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Similarly, amphetamine treatment (1 and 3 mg/kg) of the young adult PND 61 males and

females (Figure 10A and B) increased the total activity counts by subinterval in a nondose-related manner. In addition, the ambulatory activity by subinterval for males and

females (Figures 11A and B) was also increased for the majority of motor activity

assessment following amphetamine treatment (1 and 3 mg/kg). An habituation profile

was present for both total and ambulatory activity for the PND 61 control animals, with

the 3 mg/kg amphetamine treatment group only showing some possible habituation

regarding ambulatory activity. The 1 mg/kg treatment groups for both males and females

lacked habituation, with the total and ambulatory activity remaining elevated over all

subintervals. In a similar manner to the total activity, the PND 61 (0, 0.2 and 1 mg/kg)

treated females exhibited a dose response for ambulatory activity (Figure 13 A and B).

Overall, the effect of amphetamine increasing activity above baseline, as well as

inhibiting activity at higher amphetamine doses (3 mg/kg) in the PND 61 males and

females, is consistent with the previously published literature (Gaytan et al., 1996;

Mobini et al. 2000; Chatterjie et al., 1998; Yates et al., 2007).

In conclusion, the motor activity data (i.e. total activity and ambulatory activity) for

Sprague Dawley Crl:CD (SD) rats generated by the Kinder Scientific MotorMonitor

System are consistent with previously reported effects of nicotine and amphetamine on

motor behavior. This motor monitoring system is therefore capable and sensitive enough

to measure increases in motor activity in neonatal and young adult rodents with positive

control agents such as nicotine and amphetamine.

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5. REFERENCES

Acri, J.B.; Brown, K.J.; Saah, M.I.; Grunberg N.E. (1995) Strain and age differences

in acoustic startle responses and effects of nicotine in rats. Pharmacology

Biochemistry and Behavior 1995, 50. 191-198.

Bevins, R.A.; Besheer, J. Individual differences in rat locomotor activity are

diminished by nicotine through stimulation of central nicotinic acetylcholine

receptors. Physiology and Behavior 2001, 72, 237-244.

Chatterjie, N.; Sechzer, J.A.; Lieberman, K.W.; Alexander, G.J. Dextro-Naloxone

counteracts amphetamine-induced hyperactivity. Pharmacology Biochemistry and

Behavior 1998, 59, 271-274.

Domino, E.F. Nicotine induced behavioral locomotor sensitization. Progress in

Neuro-Psychopharmacological and Biological Psychiatry 2001, 25, 59-71.

Elliott, B.M.; Faraday, M.M.; Phillips, J.M.; Grunberg, N.E. Adolescent and adult

female rats differ in sensitivity to nicotine’s activity effects. Pharmacology

Biochemistry and Behavior 2005, 80, 567-575.

Faraday, M.M.; Elliott, B.M.; Phillips, J.M.; Grunberg, N.E. Adolescent and adult

male rats differ in sensitivity to nicotine’s activity effects. Pharmacology

Biochemistry, and Behavior 2003, 74, 917-931.

Gaytan, O.; Swann, A.C.; Dafny, N. Effects of amphetamine at the beginning of the

light cycle on indices of motor activity in the rat. European Journal of

Pharmacology 1996, 300, 1-8.

Gould, T.J.; Rukstalis, M.; Lewis, M.C. Atmoxetine and nicotine enhance prepulse

inhibition of acoustic startle in C57BL/6 mice. Neuroscience Letters 2005, 377,

85-90.

Lewis, M.C.; Gould, T.J. Nicotine and ethanol enhancements of acoustic startle

reflex are mediated in part by dopamine in C57BL/6J mice. Pharmacology

Biochemistry and Behavior 2003, 76, 179-186.

Mobini, S.; Chiang, T.J.; Ho, M.Y.; Bradshaw, C.M.; Szabadi, E. Comparison of the

effects of clozapine, haloperidol, chlorpromazine and d-amphetamine on

performance on a time-constrained progressive ratio schedule and on locomotor

behaviour in the rat. Psychopharmacology 2000, 152, 47-54.

Shoaib, M.; Shippenberg, T.S. Adrenalectomy attenuates nicotine-induced dopamine

release and locomotor activity in rats. Psychopharmacology 1996, 128, 343-350.

SAS® Proprietary Software, Version 8.2; SAS Institute, Inc.: Cary, NC, 1999-2001.

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Yates, J.W.; Meij, J.T.A.; Sullivan, J.R.; Richtand, N.M.; Yu, L. Bimodal effect of

amphetamine on motor behaviors in C57BL/6 mice. Neuroscience Letters 2007,

427, 66-70.

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FIGURES 1 - 13

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Mean Total Activity Counts By PND For Males

Postnatal Day

PND 13 PND 17 PND 21

Activity Counts (# of beam breaks)

0

1000

2000

3000

4000

5000

6000 Vehicle Control Group 1

Vehicle Control Group 2

Nicotine 0.1 mg/kg

Nicotine 0.5 mg/kg

A

***

x

Mean Total Activity Counts By PND For Females

Postnatal Day

PND 13 PND 17 PND 21

Activity Counts (# of beam breaks)

0

1000

2000

3000

4000

5000

6000

B

*

***

xxx

FIGURE 1. Postnatal days 13, 17, and 21 (A) male and (B) female mean total activity

counts averaged over all subintervals, expressed as mean ± SEM.

Significance between the treatment and vehicle control group 1 is

indicated by *

p<0.05 and ***p<0.001 and between the treatment and

vehicle control group 2 is indicated by x

p<0.05 and xxxp<0.001.

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Mean Ambulatory Activity By PND For Males

PND13 PND17 PND21

Activity Counts (# of beam breaks)

0

200

400

600

800

1000

1200

1400

1600

1800

2000

2200

2400

Vehicle Control Group 1

Vehicle Control Group 2

Nicotine 0.1 mg/kg

Nicotine 0.5 mg/kg

A

* *

***

xx

Mean Ambulatory Activity by PND For Females

PND 13 PND 17 PND 21

Activity Counts (# of beam breaks)

0

200

400

600

800

1000

1200

1400

1600

1800

2000

2200

2400

B

*

***

xxx

FIGURE 2. Postnatal days 13, 17, and 21 (A) male and (B) female mean ambulatory

activity counts averaged over all subintervals, expressed as mean ± SEM.

Significance between the treatment and vehicle control group 1 is

indicated by *

p<0.05 and ***p<0.001 and to group 2 is indicated by xxp<0.01 and xxxp<0.001.

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Total Activity Counts For PND 13 Males

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks) 100

200

300

400

500

600

700

800

900

Vehicle Control Group 1 

Vehicle Control Group 2 

Nicotine 0.1 mg/kg 

Nicotine 0.5 mg/kg 

A

Total Activity Counts For PND 13 Females

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks) 100

200

300

400

500

600

700

800

900 B

FIGURE 3. Postnatal day 13 (A) male and (B) female total activity counts or beam

breaks taken over each subinterval, expressed as mean ± SEM.

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Ambulatory Activity For PND 13 Males

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of bream breaks)

0

50

100

150

200

250

300

350

Vehicle Control Group 1

Vehicle Control Group 2

Nicotine 0.1 mg/kg 

Nicotine 0.5 mg/kg 

A

Ambulatory Activity For PND 13 Females

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

50

100

150

200

250

300

350 B

FIGURE 4. Postnatal day 13 (A) male and (B) female ambulatory activity counts or

beam breaks taken over each subinterval, expressed as mean ± SEM.

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Total Activity Counts For PND 17 Males

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

200

400

600

800

1000

1200

1400

1600

1800

Vehicle Control Group 1 

Vehicle Control Group 2 

Nicotine 0.1 mg/kg 

Nicotine 0.5 mg/kg

A

Total Activity Counts For PND 17 Females

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

200

400

600

800

1000

1200

1400

1600

1800

B

FIGURE 5. Postnatal day 17 (A) male and (B) female total activity counts or beam

breaks taken over each subinterval, expressed as mean ± SEM.

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Ambulatory Activity For PND 17 Males

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

100

200

300

400

500

600

700

800

900

Vehicle Control Group 1

Vehicle Control Group 2 

Nicotine 0.1 mg/kg 

Nicotine 0.5 mg/kg 

A

Ambulatory Activity For PND 17 Females

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

100

200

300

400

500

600

700

800

900

B

FIGURE 6. Postnatal day 17 (A) male and (B) female ambulatory activity counts or

beam breaks taken over each subinterval, expressed as mean ± SEM.

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Total Activity Counts For PND 21 Males

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

200

400

600

800

1000

1200

1400

1600

1800

2000

2200

Vehicle Control Group 1

Vehicle Control Group 2 

Nicotine 0.1 mg/kg 

Nicotine 0.5 mg/kg 

A

Total Activity Counts for PND 21 Females

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

200

400

600

800

1000

1200

1400

1600

1800

2000

2200

B

FIGURE 7. Postnatal day 21 (A) male and (B) female total activity counts or beam

breaks taken over each subinterval, expressed as mean ± SEM.

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Ambulatory Activity for PND 21 Males

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

200

400

600

800

1000

Vehicle Control Group 1 

Vehicle Control Group 2 

Nicotine 0.1 mg/kg 

Nicotine 0.5 mg/kg 

A

Ambulaotry Activity of PND 21 Females

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

200

400

600

800

1000

B

FIGURE 8. Postnatal day 21 (A) male and (B) female ambulatory activity counts or

beam breaks taken over each subinterval, expressed as mean ± SEM.

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Male and Female Mean Total Activity Counts For PND 61

Gender

Male Female

Activity Counts (# of beam breaks)

0

2000

4000

6000

8000

10000

12000

14000

16000

Vehicle Control Group 1 

Vehicle Control Group 2 

Amphetamine 1 mg/kg 

Amphetamine 3 mg/kg 

A

***

xxx

***

xxx

***

xxx

***

xxx

Male and Female Mean Ambulatory Counts For PND 61

Gender

Male Female

Activity Counts (# of beam breaks)

0

1000

2000

3000

4000

5000

B

***

xxx

***

xx

FIGURE 9. Postnatal day 61 male and female (A) mean total activity and (B) mean

ambulatory activity averaged over all subintervals, expressed as mean ±

SEM. Significance between the treatment and vehicle control group 1 is

indicated by ***p<0.001 and between the treatment and vehicle control

group 2 is indicated by xxp<0.01 and xxxp<0.001.

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Total Activity Counts For PND 61 Males

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

500

1000

1500

2000

2500 Vehicle Control Group 1

Vehicle Control Group 2

Amphetamine 1 mg/kg 

Amphetamine 3 mg/kg 

A

Total Activity Counts For PND 61 Females

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

500

1000

1500

2000

2500

B

FIGURE 10. Postnatal day 61 (A) male and (B) female total activity counts or beam

breaks taken over each subinterval, expressed as mean ± SEM.

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Ambulatory Activity For PND 61 Males

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

100

200

300

400

500

600

700

800

Vehicle Controle Group 1

Vehicle Control Group 2

Amphetamine 1 mg/kg 

Amphetamine 3 mg/kg 

A

Ambulatory Activity For PND 61 Females

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

100

200

300

400

500

600

700

800

B

FIGURE 11. Postnatal day 61 (A) male and (B) female ambulatory activity counts or

beam breaks taken over each subinterval, expressed as mean ± SEM.

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Female Mean Total Activity Counts For PND 61

PND 61 Female

Activity Counts (# of beam breaks)

0

2000

4000

6000

8000

10000

12000

14000

Vehicle Control

0.2 mg/kg Amphetamine

1.0 mg/kg Amphetamine

***

***

A

Female Mean Ambulatory Counts for PND 61

PND 61 Females

Activity Counts (# of beam breaks)

0

1000

2000

3000

4000

5000

**

***

B

FIGURE 12. Postnatal day 61 female (A) mean total activity and (B) mean ambulatory

activity averaged over all subintervals, expressed as mean ± SEM.

Significance between the treatment and vehicle control group is indicated

by**p<0.01 and ***p<0.001.

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Total Activity Counts For PND 61 Females

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

500

1000

1500

2000

2500

3000

Vehicle Control

0.2 mg/kg Amphetamine

1.0 mg/kg Amphetamine

A

Ambulatory Activity For PND 61 Females

Subinterval (minutes)

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

200

400

600

800

1000

B

FIGURE 13. Postnatal day 61 female (A) total activity counts and (B) ambulatory

activity counts or beam breaks taken over each subinterval, expressed as

mean ± SEM

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STUDY TITLE

A POSITIVE CONTROL ACUTE NEUROTOXICITY STUDY IN RATS

STUDY NUMBER

WIL-99443

STUDY DIRECTOR

Mark T. Herberth, BS, LAT

STUDY INITIATION DATE

2 November 2007

STUDY COMPLETION DATE

5 September 2008

PERFORMING LABORATORY

WIL Research Laboratories, LLC

1407 George Road

Ashland, OH 44805-8946

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STATEMENT OF NO DATA CONFIDENTIALITY CLAIMS

The purpose of the study was to validate the use of the Kinder Scientific MotorMonitor

System in our laboratory and to demonstrate the ability to detect decreases in activity

using this system as well as a functional observational battery (FOB). Therefore, this

page has been intentionally left blank.

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1. ABSTRACT

The objective of this study was to demonstrate the ability of the Kinder Scientific

MotorMonitor System (Kinder Scientific, LLC, Poway, CA, USA) to detect decreases in

activity in response to chlorpyrifos within the U.S. EPA Health Effects Guideline OPPTS

870.6200 (Neurotoxicity Screening Battery) and the Organization of Economic

Cooperation and Development (OECD) Guidelines for Testing of Chemicals Guideline

424 (Neurotoxicity Study in Rodents). In addition, the study evaluated the ability to

detect changes in behavior using a functional observational battery (FOB). Chlorpyrifos

was administered at a single dose of 20 or 100 mg/kg by oral gavage 3.5 hours prior to

behavioral assessment. Male and female Sprague Dawley Crl:CD (SD) rats (6 weeks of

age) were evaluated using a Neurotoxicity Screening Battery consisting of FOB

assessment and locomotor behavior. The FOB detected a general decrease in the

initiation of movement (time to first step in the open field), body temperature and

Rotarod performance, along with impaired gait and increased catalepsy time. Motor

activity (i.e., total and ambulatory activity) measured by the Kinder Scientific

MotorMonitor System showed a consistent decrease in mean activity by both males and

females treated with 100 mg/kg chlorpyrifos. The experimental design used in this study

demonstrated that WIL Research can detect behavioral changes in an FOB, as well as

locomotor effects of chlorpyrifos using the Kinder Scientific MotorMonitor System, and

that the results can be considered to validate methodologies for OPPTS Guideline

870.6200 and OECD Guideline 424.

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2. INTRODUCTION

This study was conducted in accordance with the appropriate provisions of the U.S. EPA

Health Effects Guideline (OPPTS 870.6200), Neurotoxicity Screening Battery and the

OECD Guidelines for Testing of Chemicals Guideline 424, Neurotoxicity Study in

Rodents. The exception is that the study assessments were be completed only during

pretest and at the time of peak effect on study day 0. Validation of laboratory

methodologies and demonstration of the sensitivity of the equipment to detect test articlerelated changes are requirements of these guidelines. WIL Research Laboratories, LLC

chose to evaluate the use of the Kinder Scientific MotorMonitor System to measure

locomotor behavior in control and test article-treated animals using chlorpyrifos, a known

cholinesterase inhibitor used commonly in insecticides.

In rodents, a single dose of chlorpyrifos often results in the presence of tremors, increased

lacrimation and salivation, loss of muscle tone, hypothermia, changes in gait, increased

catalepsy times and inhibited pupil responsiveness (Moser 1995; Mattsson et al., 1996).

When evaluated at the time of peak effect (approximately 3.5 hours post-administration)

these effects, specifically regarding muscle tone and function, are consistent with the

decreased motor activity observed at dose levels of 20, 50 and 100 mg/kg (Moser, 1995).

This was also noted in other studies using higher dose levels (50, 100, 150 and

200 mg/kg), administered once by oral gavage, which were sufficient to cause

generalized decreases in muscle tone and motor activity for both male and female adult

rats (Mattsson et al., 1996). This same trend was also present in low-dose (3 to

12 mg/kg) chronic studies lasting several days to weeks using male and female rats

(PND 30 and 40), where motor activity in the open field was inhibited (Carr et al., 2001).

Further analysis of chlorpyrifos via alternative delivery routes identified impaired visual

discrimination (following oral or subcutaneous administration at 50 mg/kg) and

significantly lowered general activity in the behavioral test battery (following

subcutaneous administration at 250 mg/kg) for up to 18 consecutive days (Bushnell et al.,

2001).

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3. MATERIALS AND METHODS

3.1. TEST SPECIES AND HUSBANDRY

Sprague Dawley Crl:CD(SD) rats were obtained from Charles River Laboratories, Inc.

(Raleigh, North Carolina, USA). 48 males and females (nulliparous and non-pregnant) at

3 to 5 weeks of age were ordered for the in-life testing of 12 rats/sex/group for FOB and

motor activity assessment starting at approximately 6 weeks of age. Upon receipt,

animals were housed 2-3/cage by sex. Following acclimation, the animals were

individually housed in clean suspended wire-mesh cages until euthanasia.

Environmental controls were set to maintain temperature at 71 ± 5o F and relative

humidity between 30–70%. Air handling units provided a minimum of 10 fresh air

changes per hour. Fluorescent lighting, controlled by timers, provided illumination for a

12-hour light (6:00 a.m. – 6:00 p.m.)/dark photoperiod. Temperature and relative

humidity were monitored continuously. Reverse osmosis-purified water and PMI

Nutrition International, Inc., Certified Rodent LabDiet® 5002 were offered ad libitum

during the study.

3.2. TEST MATERIAL AND PREPARATION

Chlorpyrifos was purchased from Supelco, Bellefonte, PA, USA. An appropriate amount

of chlorpyrifos was mixed with the vehicle (corn oil) to produce dosing concentrations of

4 and 20 mg/mL, with a corresponding dose volume of 5 mL/kg. Dosing solutions were

prepared daily, stored at room temperature and protected from light prior to dispensation

for dosing.

3.3. EXPERIMENTAL DESIGN

Functional observational battery assessments and locomotor activity (Kinder Scientific

MotorMonitor System) were made at pretest and approximately 3.5 hours post-dose

administration to 4 groups of 12 rats/sex/group on the day of chlorpyrifos administration.

All rats were observed twice daily for moribundity and mortality, once in the morning

and once in the afternoon until euthanasia. Body weight and clinical observations

regarding general appearance were recorded on the day of dose administration. The

observations included, but were not limited to evaluations for changes in appearance of

skin and fur, eyes, mucous membranes, respiratory and circulatory systems, autonomic

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and central nervous systems, somatomotor activity and behavior. The following table

summarizes the testing paradigm:

Group

Number Test Article

Dose Level

(mg/kg)

Number of

Males

Number of

Females

1 Vehicle Control 0 12 12

2 Vehicle Control 0 12 12

3 Chlorpyrifos 20 12 12

4 Chlorpyrifos 100 12 12

3.4. BEHAVIORAL TESTING

Twelve rats/sex/group were evaluated in the FOB and the Kinder Scientific

MotorMonitor System at pretest and on study day 0. The FOB utilized was based on

previously developed protocols which included: home cage, handling, open field,

sensory, neuromuscular and physiological observations (Moser et al., 1991; Irwin, 1968;

Gad, 1982; Moser et al., 1988; Haggerty, 1989; O'Donoghue, 1989). All animals were

observed for the following parameters as described below:

3.4.1. HOME CAGE OBSERVATIONS

Posture

Convulsions/tremors

Feces consistency

Biting

Palpebral (eyelid) closure

3.4.2. HANDLING OBSERVATIONS

Ease of removal from cage

Lacrimation/chromodacryorrhea

Piloerection

Palpebral closure

Eye prominence

Red/crusty deposits

Ease of handling animal in hand

Salivation

Fur appearance

Respiratory rate/character

Mucous membranes/eye/skin color

Muscle tone

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3.4.3. OPEN FIELD OBSERVATIONS (EVALUATED OVER A 2-MINUTE

OBSERVATION PERIOD)

Mobility

Rearing

Convulsions/tremors

Grooming

Bizarre/stereotypic behavior

Time to first step (seconds)

Gait

Arousal

Urination/defecation

Gait score

Backing

3.4.4. SENSORY OBSERVATIONS

Approach response

Startle response

Pupil response

Forelimb extension

Air righting reflex

Touch response

Tail pinch response

Eyeblink response

Hindlimb extension

Olfactory orientation

3.4.5. NEUROMUSCULAR OBSERVATIONS

Hindlimb extensor strength

Hindlimb foot splay

Grip strength-hind and forelimb

Rotarod performance

3.4.6. PHYSIOLOGICAL OBSERVATIONS

Catalepsy

Body temperature

Body weight

Testing was performed by the same technicians, whenever possible, who did not know

the animal’s group assignment. Although data were collected and statistically analyzed

for each testing parameter (when necessary) the FOB data presented in this report only

include functional domains that are significantly different from the control group and/or

were affected by test article administration. Locomotor activity was monitored with the

automated Kinder Scientific MotorMonitor System (Kinder Scientific, Poway, CA,

USA). The test session was 60 minutes in duration, consisting of 6 subintervals lasting

10 minutes each. Locomotor activity was evaluated as total and ambulatory activity

counts obtained over each subinterval (0-10 minutes, 11-20 minutes, 21-30 minutes, 31-

40 minutes, 41-50 minutes and 51-60 minutes) and the entire 60-minute session.

3.5. STATISTICAL ANALYSIS

All analyses were two-tailed for minimum significance levels of 5% and 1%. All

statistical tests were performed by a computer with appropriate programming as

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referenced below. Total and ambulatory counts were analyzed, by sex and session, with

a repeated measures analysis of variance (RANOVA). Factors in the model included

treatment group (TRT), time interval (TIME), and the interaction of time interval and

treatment group (TRT*TIME). The SAS® procedure PROC MIXED was used for

analysis with the random effect of animal included as the repeated measurement. The

covariance structure across time was selected by comparing Akaike's Information

Criterion.

Continuous FOB data were subjected to parametric one-way analysis of variance

(ANOVA) to determine intergroup differences (Snedecor, 1980). If significant

differences were determined by the ANOVA, Dunnett’s test (Dunnett, 1964) was used to

compare each control group with the test article-treated groups. Functional Observational

Battery parameters yielding scalar or descriptive data were analyzed by Fisher’s Exact

Test (Steel and Torrie, 1980).

The monotonic dose-response relationship was evaluated using sequential linear trend

tests based on ordinal spacing of dose levels. The linear dose by time interaction was

evaluated and, if significant at the 0.05 level, trend tests on treatment means were

performed at the 0.05 level for each time interval.

Nonmonotonic dose responses were evaluated whenever no significant linear trends were

detected, but TRT and/or TRT*TIME were significant at the 0.01 level. Within the

framework of the RANOVA, pairwise comparisons were made for each individual test

article-treated group with each control group through linear contrasts. If TRT*TIME was

significant, the comparisons were conducted for each time interval. If only the TRT

effect was significant, the comparisons were conducted across the pooled time intervals

of the entire session. These nonmonotonic dose-response comparisons were conducted at

the 0.01 significance level.

All statistical analyses for locomotor activity were conducted by BioSTAT Consultants,

Inc., Portage, MI, USA, using Version 9.1 (SAS Institute, Inc., 2002-2003) software.

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4. RESULTS AND DISCUSSION

The FOB performed prior to chlorpyrifos administration (pretest) showed no differences

in handling, sensory, neuromuscular and physiological parameters. Increased urination

(in the open field; p<0.05 or p<0.01, Table 4) by females assigned to the 20 mg/kg

chlorpyrifos groups; as well as a longer time to first step by 20 mg/kg chlorpyrifos treated

males (p<0.01), compared to control groups 1 or 2. However, approximately 3.5 hours

following dose administration, chlorpyrifos-treated animals exhibited test article-related

differences (compared to the control groups) in the home cage, open field, neuromuscular

and physiological parameters, while handling and sensory parameters were largely

unaffected. This was not considered to be test article related since the differences were

not consistent between control groups 1 and 2.

4.1. HOME CAGE AND OPEN FIELD ASSESSMENTS

The first two components of the FOB, including home cage and open field assessments

identified repetitive movement of the mouth and jaw (1 female each at 20 mg/kg and

100 mg/kg and 2 males at 100 mg/kg; Table 2) in the home cage, which is an expected

effect of chlorpyrifos treatment. The open field observations during the FOB test

identified a more robust test article-related effect with an increased time until the

initiation of motor behavior, i.e., the first step taken, for both the 100 mg/kg group males

and females (Table 4, p<0.01). This increased latency compared to both vehicle control

group males and females, indicates that chlorpyrifos treatment prolonged the time to

initiation of motor movement and inhibited motor function. This, along with the general

decline in mean total and ambulatory activity, further suggests that chlorpyrifos impaired

movement. Another aspect of motor movement, gait, was affected by chlorpyrifos

administration (Table 4). The numbers of males and females with normal gait were

decreased in the 100 mg/kg group (the difference was significant [p<0.01] for males

compared to both control groups). Specifically, both sexes showed an increase in the

incidence of hunched body posture; splayed or dragging hind limbs were also noted for

1 male, while 2 females were observed walking on tiptoes. These effects on gait are

consistent with decreases in motor activity as well as the results of previous research

regarding chlorpyrifos and motor behavior (Moser, 1995; Mattsson et al., 1996; Carr et

al., 2001; Bushnell et al., 2001). In addition, there was a significant decrease in the

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number of rears exhibited by chlorpyrifos treated females (100 mg/kg) compared to

control group 1 (Table 4, p<0.05).

4.2. NEUROMUSCULAR ASSESSMENT

Neuromuscular impairment was particularly evident in males and females receiving the

100 mg/kg dose, where Rotarod performance (Table 6) was significantly decreased

compared to both control groups (p<0.05 or p<0.01) and decreased compared to pretest;

1 male and 1 female in the 100 mg/kg group also exhibited slight tremors. This would

indicate that there was impaired motor movement and/or balance. Since locomotor

activity data also showed a decline in mean total and ambulatory activity, chlorpyrifos

was indeed acting to impair motor function. In females, there was an apparent increase in

forelimb grip strength (Table 6) at the 20 mg/kg dose (p<0.05); although not significant,

this same group of females also had the greatest grip strength during the pretest

evaluations (Table 5). The FOB data regarding impaired motor movement/balance and

decreased activity are supported by published studies addressing neuromuscular

impairments and chlorpyrifos (Moser 1995; Mattsson et al., 1996).

4.3. PHYSIOLOGICAL ASSESSMENT

Physiological parameters, specifically catalepsy and body temperature, were also affected

by chlorpyrifos treatment in males and/or females (Table 8). Catalepsy time (the length

of time spent motionless) was significantly increased in 100 mg/kg group males (p<0.05).

The increased catalepsy time corresponds to the previously discussed impairments in the

initiation and overall motor behaviors examined. Along with the increased catalepsy

time, there were significantly decreased body temperatures (p<0.01) for males and

females in the 100 mg/kg group. The results are consistent with similar doses used in

published research, which also show increased catalepsy time and decreased body

temperature (Moser 1995; Mattsson et al., 1996; Timofeeva and Gordon, 2002).

4.4. MOTOR ACTIVITY

The motor activity data over all 6 subintervals measured by the Kinder Scientific

MotorMonitor System in the pretest male and female groups show that there was no

difference in mean total and ambulatory activity prior to chlorpyrifos administration

(Figure 1A and 2A). Examining the total and ambulatory activity during the

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6 subintervals also shows no difference prior to chlorpyrifos treatment in pretest males

and females (Figure 3A and B, Figure 4A and B). In addition, there was an habituation

profile present for both males and females over the 6 subintervals prior to chlorpyrifos

administration. These similarities were expected, as there was no test article

administered.

There was a significant decrease (p<0.01 or p<0.001) in mean total and ambulatory

activity counts compared to the vehicle control groups following delivery of 100 mg/kg

chlorpyrifos to males and females and following delivery of 20 mg/kg chlorpyrifos to

females (Figure 1B, Figure 2B) approximately 3.5 hours following chlorpyrifos delivery.

With respect to the individual subintervals of total and ambulatory activity, there were

similar decreases in activity following chlorpyrifos treatment over the first 2 subintervals

(1-10 minutes and 11-20 minutes) in males at 100 mg/kg and females at 20 and

100 mg/kg (Figure 5A and B, Figure 6A and B). These decreases in activity also

followed a dose-dependent profile with the highest level of chlorpyrifos (100 mg/kg)

resulting in the lowest overall activity. Females appeared to be more sensitive to

chlorpyrifos treatment, as both the low and high doses (20 and 100 mg/kg, respectively)

resulted in decreased activity, similar to behavioral results observed in the FOB.

Because there were no differences in motor activity prior to chlorpyrifos administration,

the decreased total and ambulatory activity can be attributed to chlorpyrifos. These

decreases in motor activity are also consistent with the results of previous studies at

similar dose levels of chlorpyrifos (Moser 1995; Mattsson et al., 1996; Carr et al., 2001;

Bushnell et al., 2001).

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5. CONCLUSION

In conclusion, the data generated using the functional observational battery and Kinder

Scientific MotorMonitor System in male and female Sprague Dawley Crl:CD (SD) rats

are consistent with the cited effects of chlorpyrifos on motor behavior. These procedures

are therefore capable and sensitive enough to detect reductions in motor function with the

positive control agent, chlorpyrifos, and can be considered to validate methodologies for

OPPTS Guideline 870.6200 and OECD Guideline 424.

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6. REFERENCES

Bushnell, P.J.; Moser, V.C.; Samsam, T.E. Comparing cognitive and screening tests

for neurotoxicity: Effects of acute chlorpyrifos on visual signal detection and a

neurobehavioral test battery in rats. Neurotoxicology and Teratology 2001, 23, 33-

44.

Carr, R.L.; Chambers, H.W.; Guarisco, J.A.; Richardson, J.R.; Tang, J.; Chambers,

J.E. Effects of repeated oral postnatal exposure to chlorpyrifos on open-field

behavior in juvenile rats. Toxicological Sciences 2001, 59, 260-267.

Dunnett, C.W. New tables for multiple comparisons with a control. Biometrics

1964, 20, 482-491.

Gad, S.C. A neuromuscular screen for use in industrial toxicology. Journal of

Toxicology and Environmental Health. 1982, 9, 691-704.

Haggerty, G.C. Development of Tier I neurobehavioral testing capabilities for

incorporation into pivotal rodent safety assessment studies. Journal of American

College of Toxicology 1989, 8, 53-69.

Irwin, S. Comprehensive observational assessment: Ia. A systematic quantitative

procedure for assessing the behavioral physiological state of the mouse.

Psychopharmacologia 1968, 13, 222-257.

Mattsson, J.L.; Wilmer J.W.; Shankar, M.R.; Berdasco, N.M.; Crissman, J.W.;

Maurissen, J.P.; Bond D.M. (1996) Single-dose and 13-week repeated dose

neurotoxicity screening studies of chlorpyrifos insecticide. Food and Chemical

Toxicology 1996, 34, 393-405.

Moser, V.C.; McCormick, J.P.; Creason, J.P.; MacPhail, R.C. Comparison of ,

chlordimeform and carbaryl using a functional observational battery. Fundamentals

of Applied Toxicology 1988, 11, 189-206.

Moser, V.C.; McDaniel, K.L.; Phillips, P.M. Rat strain and stock comparisons using

a functional observational battery: Baseline values and effects of Amitraz

Toxicology and Applied Pharmacology 1991, 108, 267-283.

Moser, V.C. Comparisons of the acute effects of cholinesterase inhibitors using a

neurobehavioral screening battery in rats. Neurotoxicology and Teratology 1995,

17, 617-625.

O'Donoghue, J.L. Screening for neurotoxicity using a neurologically based

examination and neuropathology. Journal of American College of Toxicology 1989,

8, 97-116.

SAS Institute, Inc. SAS® Proprietary Software Release, Version 9.1, SAS Institute,

Inc.: Cary, NC, 2002-2003.

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Snedecor, G.W.; Cochran, W.G. One Way Classifications; Analysis of Variance. In

Statistical Methods, 7th ed.; The Iowa State University Press: Ames, IA, 1980,

215-237

Steel R.G.D; Torrie, J.H. Principles and Procedures of Statistics, A Biometrical

Approach, Second Edition. McGraw-Hill Book Company, New York, NY, 1980,

pp. 471-472.

Timofeeva, O.A.; Gordon, C.G. EEG spectra, behavioral states and motor activity in

rats exposed to acetylcholinesterase inhibitor chlorpyrifos. Pharmacology

Biochemistry and Behavior 2002, 72, 669-679.

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FIGURES 1-6

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Pretest Mean Total Activity For Males and Females 

(Prior to Chlorpyrifos Treatment)

Gender

Male Female

Activity Counts (# of beam breaks)

0

500

1000

1500

2000

2500

3000

3500 Vehicle Control Group 1

Vehicle Control Group 2

Chlorpyrifos 20 mg/kg

Chlorpyrifos 100 mg/kg 

A

Study Day 0 Mean Total Activity For Males and Females 

(Following Chlorpyrifos Treatment)

Gender

Male Female

Activity Counts (# of beam breaks)

0

500

1000

1500

2000

2500

3000

3500

B

***

xxx

xx

***

xx

FIGURE 1. Mean total activity counts over all subintervals for (A) males and females

at pretest and (B) males and females on Study Day 0, expressed as mean ±

SEM. Significance between the treatment groups and vehicle control

group 1 is indicated by ***p<0.001 and between the treatment and vehicle

control group 2 is indicated by xxp<0.01 and xxxp<0.001.

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Pretest Mean Ambulatory Activity For Males and Females 

(Prior to Chlorpyrifos Treatment)

Gender

Male Female

Activity Counts (# of beam breaks)

0

200

400

600

800

1000

Vehicle Control Group 1

Vehicle Controle Group 2

Chlorpyrifos 20 mg/kg

Chlorpyrifos 100 mg/kg

A

Study Day 0 Mean Ambulatory Activity For Males and Females

(Following Chlorpyrios Treatment)

Gender

Male Female

Activity Counts (# of beam breaks)

0

200

400

600

800

1000

B

***

xxx

*

xxx

***

xxx

FIGURE 2. Mean ambulatory counts over all subintervals for (A) males and females

and (B) males and females on Study Day 0, expressed as mean ± SEM.

Significance between the treatment groups and vehicle control group 1 is

indicated by *

p<0.05 and ***p<0.001 and between the treatment and

vehicle control group 2 is indicated by xxxp<0.001.

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Pretest Total Activity Counts For Males 

(Prior to Chlorpyrifos Treatment)

Subinterval

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

200

400

600

800

1000

1200

1400

1600

Vehicle Control Group 1

Vehicle Control Group 2 

Chlorpyrifos 20 mg/kg 

Chlorpyrifos 100 mg/kg 

A

Pretest Total Activity Counts For Females 

(Prior to Chlorpyrifos Treatment)

Subinterval

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

200

400

600

800

1000

1200

1400

1600

B

FIGURE 3. Total activity counts over each subinterval for (A) males at pretest and

(B) pretest females at pretest, expressed as mean ± SEM

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WIL-99443

Pretest Ambulatory Activity Counts For Males 

(Prior to Chlorpyrifos Treatment)

Subinterval

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

100

200

300

400

500

600

Vehicle Control Group 1

Vehicle Control Group 2

Chlorpyrifos 20 mg/kg 

Chlorpyrifos 100 mg/kg 

A

Pretest Ambulatory Activity Counts For Females 

(Prior to Chlorpyrifos Treatment)

Subinterval

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

100

200

300

400

500

600

B

FIGURE 4. Total ambulatory activity counts over each subinterval for (A) males at

pretest and (B) females at pretest, expressed as means ± SEM

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Study Day 0 Total Activity Counts For Males 

(Following Chlorpyrifos Treatment)

Subinterval

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

200

400

600

800

1000

1200

1400

1600

Vehicle Control Group 1

Vehicle Control Group 2

Chlorpyrifos 20 mg/kg

Chlorpyrifos 100 mg/kg

A

Study Day 0 Activity Counts For Females 

(Following Chlorpyrifos Treatment)

Trial Block

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# beam breaks)

0

200

400

600

800

1000

1200

1400

1600

B

FIGURE 5. Total activity counts over each subinterval for (A) males on Study Day 0

and (B) females on Study Day 0, expressed as mean ± SEM

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Study Day 0 Ambulatory Activity Counts For Males

(Following Chlorpyrifos Treatment)

Subinterval

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

100

200

300

400

500

600

Vehicle Control Group 1

Vehicle Control Group 2

Chlorpyrifos 20 mg/kg

Chlorpyrifos 100 mg/kg

A

Study Day 0 Ambulatory Activity Counts For Females 

(Following Chlorpyrifos Treatment)

Subinterval

1-10 11-20 21-30 31-40 41-50 51-60

Activity Counts (# of beam breaks)

0

100

200

300

400

500

600

B

FIGURE 6. Total ambulatory activity counts over each subinterval for (A) males on

Study Day 0 and (B) females on Study Day 0, expressed as mean ± SEM

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FOB SUMMARY TABLES

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 TABLE 1 (HOME CAGE OBSERVATIONS - PRETEST EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 1  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST  HOME CAGE OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  POSTURE  SITTING OR STANDING NORMALLY 7 7 7 6  ASLEEP, LYING ON SIDE OR CURLED UP 5 5 5 6  CONVULSIONS - CLONIC  ABSENT 12 12 12 12  CONVULSIONS - TONIC  ABSENT 12 12 12 12  TREMORS  NONE 12 12 12 12  BITING  NONE 12 12 12 12  PALPEBRAL CLOSURE  EYELIDS WIDE OPEN 7 8 6 6  EYELIDS SLIGHTLY DROOPING 0 0 1 0  DROOPING EYELIDS (HALF-CLOSED) 1 0 1 0  EYELIDS COMPLETELY SHUT 4 4 4 6  FECES CONSISTENCY  PELLETS 11 10 8 9  PELLETS ABSENT 1 2 4 3  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING FISHER’S EXACT TEST 

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 TABLE 1 (HOME CAGE OBSERVATIONS - PRETEST EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 2  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST  HOME CAGE OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  POSTURE  SITTING OR STANDING NORMALLY 5 6 5 7  ASLEEP, LYING ON SIDE OR CURLED UP 6 6 7 5  ALERT, ORIENTED TOWARD OBSERVER 1 0 0 0  CONVULSIONS - CLONIC  ABSENT 12 12 12 12  CONVULSIONS - TONIC  ABSENT 12 12 12 12  TREMORS  NONE 12 12 12 12  BITING  NONE 12 12 12 12  PALPEBRAL CLOSURE  EYELIDS WIDE OPEN 6 6 6 7  DROOPING EYELIDS (HALF-CLOSED) 0 0 1 1  EYELIDS COMPLETELY SHUT 6 6 5 4  FECES CONSISTENCY  PELLETS 9 8 10 8  PELLETS ABSENT 3 4 2 4  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING FISHER’S EXACT TEST  PFOBSUv4.29  05/15/2008  R:05/15/2008 

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 TABLE 2 (HOME CAGE OBSERVATIONS - DAY 0 EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 1  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA DAY 0  HOME CAGE OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  POSTURE  SITTING OR STANDING NORMALLY 2 7 7 9a ASLEEP, LYING ON SIDE OR CURLED UP 10 5 5 1b SITTING, HEAD HELD LOW 0 0 0 2  CONVULSIONS - CLONIC  ABSENT 12 12 12 10  REPETITIVE MOVEMENT OF MOUTH AND JAWS 0 0 0 2  CONVULSIONS - TONIC  ABSENT 12 12 12 12  TREMORS  NONE 12 12 12 12  BITING  NONE 12 12 12 12  PALPEBRAL CLOSURE  EYELIDS WIDE OPEN 2 8 7 10b EYELIDS SLIGHTLY DROOPING 0 0 0 1  EYELIDS COMPLETELY SHUT 10 4 5 1b FECES CONSISTENCY  PELLETS 3 7 5 9a PELLETS ABSENT 9 5 7 3a -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  a = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 1 AT 0.05 USING FISHER’S EXACT TEST  b = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 1 AT 0.01 USING FISHER’S EXACT TEST  c = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.05 USING FISHER’S EXACT TEST 

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 TABLE 2 (HOME CAGE OBSERVATIONS - DAY 0 EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 2  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA DAY 0  HOME CAGE OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  POSTURE  SITTING OR STANDING NORMALLY 4 8 8 11b ASLEEP, LYING ON SIDE OR CURLED UP 8 4 3 1b ALERT, ORIENTED TOWARD OBSERVER 0 0 1 0  CONVULSIONS - CLONIC  ABSENT 12 12 11 11  REPETITIVE MOVEMENT OF MOUTH AND JAWS 0 0 1 1  CONVULSIONS - TONIC  ABSENT 12 12 12 12  TREMORS  NONE 12 12 12 12  BITING  NONE 12 12 12 11  BITING OF SELF 0 0 0 1  PALPEBRAL CLOSURE  EYELIDS WIDE OPEN 4 8 9 10a EYELIDS SLIGHTLY DROOPING 1 0 0 1  DROOPING EYELIDS (HALF-CLOSED) 1 0 1 0  EYELIDS COMPLETELY SHUT 6 4 2 1  FECES CONSISTENCY  PELLETS 6 5 5 7  PELLETS ABSENT 6 7 7 5  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  a = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 1 AT 0.05 USING FISHER’S EXACT TEST  b = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 1 AT 0.01 USING FISHER’S EXACT TEST  PFOBSUv4.29  05/15/2008  R:07/25/2008 

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 TABLE 3 (OPEN FIELD OBSERVATIONS - PRETEST EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 1  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST  OPEN FIELD OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  TIME TO FIRST STEP (seconds) : MEAN 0.4 0.4 0.6g 0.5  S.D. 0.14 0.09 0.40 0.14  MOBILITY  NORMAL 12 12 12 12  GAIT  NORMAL 12 12 12 12  CONVULSIONS - CLONIC  ABSENT 12 12 12 12  CONVULSIONS - TONIC  ABSENT 12 12 12 12  TREMORS  NONE 12 12 12 12  GAIT SCORE  NORMAL 12 12 12 12  AROUSAL  NORMAL: ALERT, EXPLORATORY MOVEMENTS 12 12 12 12  BIZARRE/STEREOTYPIC BEHAVIOR  NONE 12 12 12 12  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  g = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.05 USING DUNNETT’S TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING FISHER’S EXACT TEST 

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 TABLE 3 (OPEN FIELD OBSERVATIONS - PRETEST EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 2  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST  OPEN FIELD OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  REARING : MEAN 5.1 4.4 4.7 6.5  S.D. 2.64 2.50 2.50 2.20  BACKING : MEAN 0.0 0.0 0.0 0.0  S.D. 0.00 0.00 0.00 0.00  GROOMING : MEAN 0.3 0.3 0.1 0.5  S.D. 0.65 0.45 0.29 0.80  URINATION : MEAN 0.7 0.3 0.5 0.6  S.D. 0.65 0.49 0.52 0.67  DEFECATION : MEAN 0.3 0.3 0.3 0.7  S.D. 0.89 0.49 0.62 1.37  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

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 TABLE 3 (OPEN FIELD OBSERVATIONS - PRETEST EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 3  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST  OPEN FIELD OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  TIME TO FIRST STEP (seconds) : MEAN 0.5 0.5 0.4 0.4  S.D. 0.26 0.14 0.14 0.20  MOBILITY  NORMAL 12 12 12 12  GAIT  NORMAL 12 12 12 12  CONVULSIONS - CLONIC  ABSENT 12 12 12 12  CONVULSIONS - TONIC  ABSENT 12 12 12 12  TREMORS  NONE 12 12 12 12  GAIT SCORE  NORMAL 12 12 12 12  AROUSAL  NORMAL: ALERT, EXPLORATORY MOVEMENTS 12 12 12 12  BIZARRE/STEREOTYPIC BEHAVIOR  NONE 12 12 12 12  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING FISHER’S EXACT TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

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 TABLE 3 (OPEN FIELD OBSERVATIONS - PRETEST EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 4  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST  OPEN FIELD OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  REARING : MEAN 6.2 7.5 5.9 6.6  S.D. 3.24 3.61 2.15 3.70  BACKING : MEAN 0.0 0.0 0.0 0.0  S.D. 0.00 0.00 0.00 0.00  GROOMING : MEAN 0.2 0.1 0.3 0.3  S.D. 0.39 0.29 0.62 0.87  URINATION : MEAN 0.2 0.1 0.8eh 0.2  S.D. 0.39 0.29 0.62 0.39  DEFECATION : MEAN 0.2 0.0 0.2 0.0  S.D. 0.39 0.00 0.39 0.00  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  e = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 1 AT 0.05 USING DUNNETT’S TEST  h = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.01 USING DUNNETT’S TEST  PFOBSUv4.29  05/15/2008  R:05/15/2008 

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 TABLE 4 (OPEN FIELD OBSERVATIONS - DAY 0 EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 1  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA DAY 0  OPEN FIELD OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  TIME TO FIRST STEP (seconds) : MEAN 0.5 0.5 0.6 1.7fh  S.D. 0.13 0.21 0.11 1.17  MOBILITY  NORMAL 12 12 12 12  GAIT  NORMAL 12 12 12 5bd  HINDLIMBS SPLAYED OR DRAGGING, UNABLE TO SUPPORT WEIGHT 0 0 0 1  HUNCHED BODY 0 0 0 7bd  CONVULSIONS - CLONIC  ABSENT 12 12 12 12  CONVULSIONS - TONIC  ABSENT 12 12 12 12  TREMORS  NONE 12 12 12 11  SLIGHT (1.5mm) 0 0 0 1  GAIT SCORE  NORMAL 12 12 12 12  AROUSAL  NORMAL: ALERT, EXPLORATORY MOVEMENTS 12 12 12 12  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  b = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 1 AT 0.01 USING FISHER’S EXACT TEST  d = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.01 USING FISHER’S EXACT TEST  f = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 1 AT 0.01 USING DUNNETT’S TEST  h = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.01 USING DUNNETT’S TEST 

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 TABLE 4 (OPEN FIELD OBSERVATIONS - DAY 0 EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 2  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA DAY 0  OPEN FIELD OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  BIZARRE/STEREOTYPIC BEHAVIOR  NONE 12 12 12 12  REARING : MEAN 1.6 1.5 1.4 1.1  S.D. 2.61 1.88 1.44 1.44  BACKING : MEAN 0.0 0.0 0.0 0.0  S.D. 0.00 0.00 0.00 0.00  GROOMING : MEAN 0.3 0.2 0.0 0.3  S.D. 0.65 0.39 0.00 0.45  URINATION : MEAN 0.4 0.0 0.5 0.4  S.D. 0.67 0.00 0.80 0.51  DEFECATION : MEAN 0.8 1.3 1.0 0.1  S.D. 0.83 1.91 1.48 0.29  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING FISHER’S EXACT TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

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 TABLE 4 (OPEN FIELD OBSERVATIONS - DAY 0 EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 3  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA DAY 0  OPEN FIELD OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  TIME TO FIRST STEP (seconds) : MEAN 0.5 0.5 0.5 0.9fh  S.D. 0.12 0.11 0.08 0.59  MOBILITY  NORMAL 12 12 12 12  GAIT  NORMAL 12 11 10 8  WALKS ON TIPTOES 0 1 0 2  HUNCHED BODY 0 1 2 4  CONVULSIONS - CLONIC  ABSENT 12 12 12 12  CONVULSIONS - TONIC  ABSENT 12 12 12 12  TREMORS  NONE 12 12 12 11  SLIGHT (1.5mm) 0 0 0 1  GAIT SCORE  NORMAL 12 12 12 12  AROUSAL  NORMAL: ALERT, EXPLORATORY MOVEMENTS 12 12 12 12  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  f = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 1 AT 0.01 USING DUNNETT’S TEST  h = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.01 USING DUNNETT’S TEST 

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 TABLE 4 (OPEN FIELD OBSERVATIONS - DAY 0 EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 4  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA DAY 0  OPEN FIELD OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  BIZARRE/STEREOTYPIC BEHAVIOR  NONE 12 12 12 12  REARING : MEAN 3.2 3.8 1.9 1.7g S.D. 2.98 3.35 1.31 1.50  BACKING : MEAN 0.0 0.0 0.0 0.0  S.D. 0.00 0.00 0.00 0.00  GROOMING : MEAN 0.1 0.0 0.0 0.4  S.D. 0.29 0.00 0.00 0.90  URINATION : MEAN 0.1 0.3 0.6 0.1  S.D. 0.29 0.62 0.90 0.29  DEFECATION : MEAN 0.3 0.2 0.3 0.3  S.D. 1.15 0.58 0.65 0.87  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING FISHER’S EXACT TEST  g = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.05 USING DUNNETT’S TEST  PFOBSUv4.29  05/15/2008  R:05/15/2008 

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 TABLE 5 (NEUROMUSCULAR OBSERVATIONS - PRETEST EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 1  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST  NEUROMUSCULAR OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  HINDLIMB EXTENSOR STRENGTH  HINDLIMB RESISTANCE PRESENT 12 12 12 12  GRIP STRENGTH (g) - FORE/HINDLIMB FORE: MEAN 384.7 418.1 423.9 422.3  S.D. 66.82 87.88 80.50 42.51  HIND: MEAN 182.7 190.8 207.3 182.2  S.D. 33.98 51.73 61.44 46.11  ROTAROD PERFORMANCE (seconds) : MEAN 60.9 91.4 100.5 83.0  S.D. 44.42 38.59 38.60 43.89  HINDLIMB FOOTSPLAY (mm) : MEAN 54.5 58.6 58.5 61.8  S.D. 13.79 10.00 15.99 12.04  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING FISHER’S EXACT TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

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 TABLE 5 (NEUROMUSCULAR OBSERVATIONS - PRETEST EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 2  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST  NEUROMUSCULAR OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  HINDLIMB EXTENSOR STRENGTH  HINDLIMB RESISTANCE PRESENT 12 12 12 12  GRIP STRENGTH (g) - FORE/HINDLIMB FORE: MEAN 382.8 391.8 405.9 383.2  S.D. 55.42 63.42 71.51 88.78  HIND: MEAN 181.9 196.9 200.7 185.6  S.D. 46.04 59.21 57.78 45.55  ROTAROD PERFORMANCE (seconds) : MEAN 92.8 89.0 81.6 84.1  S.D. 38.53 45.94 42.50 39.89  HINDLIMB FOOTSPLAY (mm) : MEAN 55.5 57.6 56.3 61.1  S.D. 9.62 19.84 10.42 12.03  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING FISHER’S EXACT TEST  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST  PFOBSUv4.29  05/15/2008  R:05/15/2008 

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 TABLE 6 (NEUROMUSCULAR OBSERVATIONS - DAY 0 EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 1  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA DAY 0  NEUROMUSCULAR OBSERVATIONS  MALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  HINDLIMB EXTENSOR STRENGTH  REDUCED HINDLIMB RESISTANCE, ANIMAL SHOWS SOME WEAKNESS 0 1 0 4  HINDLIMB RESISTANCE PRESENT 12 11 12 8  GRIP STRENGTH (g) - FORE/HINDLIMB FORE: MEAN 506.5 532.1 552.8 661.3e  S.D. 123.84 175.17 170.47 88.68  HIND: MEAN 317.7 308.8 298.7 336.4  S.D. 100.42 98.90 67.93 77.86  ROTAROD PERFORMANCE (seconds) : MEAN 87.0 120.0 98.7 41.7eh  S.D. 45.07 0.00 34.62 41.13  HINDLIMB FOOTSPLAY (mm) : MEAN 55.1 62.2 56.9 48.6  S.D. 10.47 10.99 14.61 15.29  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  e = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 1 AT 0.05 USING DUNNETT’S TEST  h = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.01 USING DUNNETT’S TEST  NONE SIGNIFICANTLY DIFFERENT FROM CONTROLS USING FISHER’S EXACT TEST 

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 TABLE 6 (NEUROMUSCULAR OBSERVATIONS - DAY 0 EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 2  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA DAY 0  NEUROMUSCULAR OBSERVATIONS  FEMALES  NUMBER OF ANIMALS SHOWING EACH OBSERVATION  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  HINDLIMB EXTENSOR STRENGTH  REDUCED HINDLIMB RESISTANCE, ANIMAL SHOWS SOME WEAKNESS 0 0 0 3  HINDLIMB RESISTANCE PRESENT 12 12 12 9  GRIP STRENGTH (g) - FORE/HINDLIMB FORE: MEAN 512.2 591.8 622.8e 537.8  S.D. 96.35 85.27 118.23 108.67  HIND: MEAN 308.6 343.7 306.3 307.3  S.D. 107.05 101.68 80.22 49.45  ROTAROD PERFORMANCE (seconds) : MEAN 103.7 113.0 102.3 71.7h  S.D. 38.61 20.76 34.06 37.23  HINDLIMB FOOTSPLAY (mm) : MEAN 54.8 59.8 51.2 47.0  S.D. 9.11 19.99 11.95 16.91  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  e = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 1 AT 0.05 USING DUNNETT’S TEST  h = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.01 USING DUNNETT’S TEST  NONE SIGNIFICANTLY DIFFERENT FROM CONTROLS USING FISHER’S EXACT TEST  PFOBSUv4.29  05/15/2008  R:05/15/2008 

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 TABLE 7 (PHYSIOLOGICAL OBSERVATIONS - PRETEST EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 1  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST  PHYSIOLOGICAL OBSERVATIONS  MALES  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  CATALEPSY (seconds) : MEAN 0.2 0.2 0.2 0.2  S.D. 0.00 0.00 0.00 0.00  N 12 12 12 12  BODY TEMPERATURE (degrees C) : MEAN 37.8 38.0 37.9 38.0  S.D. 0.26 0.30 0.27 0.33  N 12 12 12 12  BODY WEIGHT (g) : MEAN 135.3 135.8 136.0 135.5  S.D. 29.86 26.22 25.83 20.26  N 12 12 12 12  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST 

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 TABLE 7 (PHYSIOLOGICAL OBSERVATIONS - PRETEST EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 2  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA PRETEST  PHYSIOLOGICAL OBSERVATIONS  FEMALES  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  CATALEPSY (seconds) : MEAN 0.2 0.2 0.2 0.2  S.D. 0.03 0.00 0.00 0.00  N 12 12 12 12  BODY TEMPERATURE (degrees C) : MEAN 37.9 37.9 37.8 37.9  S.D. 0.34 0.31 0.32 0.20  N 12 12 12 12  BODY WEIGHT (g) : MEAN 118.2 114.5 113.7 115.8  S.D. 16.19 12.50 13.12 10.17  N 12 12 12 12  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  NONE SIGNIFICANTLY DIFFERENT FROM THE CONTROLS USING DUNNETT’S TEST  PFOBSUv4.29  05/15/2008  R:05/15/2008 

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 TABLE 8 (PHYSIOLOGICAL OBSERVATIONS - DAY 0 EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 1  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA DAY 0  PHYSIOLOGICAL OBSERVATIONS  MALES  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  CATALEPSY (seconds) : MEAN 0.5 0.5 0.5 1.7eg  S.D. 0.21 0.16 0.17 2.01  N 12 12 12 12  BODY TEMPERATURE (degrees C) : MEAN 37.7 37.7 37.5 35.1fh  S.D. 0.67 0.80 0.93 1.03  N 12 12 12 12  BODY WEIGHT (g) : MEAN 204.9 203.0 203.6 200.2  S.D. 31.80 28.79 26.93 26.38  N 12 12 12 12  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  e = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 1 AT 0.05 USING DUNNETT’S TEST  f = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.01 USING DUNNETT’S TEST  g = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.05 USING DUNNETT’S TEST  h = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.01 USING DUNNETT’S TEST 

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 TABLE 8 (PHYSIOLOGICAL OBSERVATIONS - DAY 0 EVALUATION) 

 PROJECT NO.:WIL-99443 POSITIVE CONTROL NT STUDY IN RATS USING CHLORPYRIFOS PAGE 2  SPONSOR:WIL RESEARCH SUMMARY OF FUNCTIONAL OBSERVATIONAL BATTERY DATA DAY 0  PHYSIOLOGICAL OBSERVATIONS  FEMALES  -----------------------------------------------------------------------------------------------------------------------------------  GROUP: 1 2 3 4  -----------------------------------------------------------------------------------------------------------------------------------  NUMBER TESTED: 12 12 12 12  CATALEPSY (seconds) : MEAN 0.5 0.5 0.6 0.7  S.D. 0.22 0.17 0.41 0.62  N 12 12 12 12  BODY TEMPERATURE (degrees C) : MEAN 37.6 37.8 37.1 35.8fh  S.D. 0.93 0.90 1.10 1.02  N 12 12 12 12  BODY WEIGHT (g) : MEAN 157.4 152.6 149.9 150.2  S.D. 13.69 12.05 14.09 9.68  N 12 12 12 12  -----------------------------------------------------------------------------------------------------------------------------------  1- 0 MG/KG 2- 0 MG/KG 3- 20 MG/KG 4- 100 MG/KG  f = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.01 USING DUNNETT’S TEST  h = SIGNIFICANTLY DIFFERENT FROM CONTROL GROUP 2 AT 0.01 USING DUNNETT’S TEST  PFOBSUv4.29  05/15/2008  R:05/15/2008 

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WIL-99263

AN INTER-OBSERVER RELIABILITY STUDY OF TECHNICIANS

ASSIGNED TO PERFORM FUNCTIONAL OBSERVATIONAL

BATTERY ASSESSMENTS IN RATS

Study Date Range: December 14, 2001 - October 9, 2002

STUDY OBJECTIVE:

The objective of this study was to train personnel to conduct the Functional

Observational Battery (FOB) and to assess inter-observer reliability of the same

technicians. FOB. inter-observer reliability studies serve as training for new employees,

as well as on-going training for current employees.

CONTROL ARTICLES:

Deionized water was used as the negative control article. Two positive control articles,

3,3 ́-Iminodipropionitrile (IDPN) and Parathion, were used to elicit behavioral changes in

the animals. IDPN was administered orally at 2000 mg/kg, and Parathion was

administered orally at 4 mg/kg. All control articles were administered as a single dose.

TEST SYSTEM:

All animals used on the study were female Sprague-Dawley Crl:CD® (SD)IGS BR rats

obtained from the WIL Research Laboratories, Inc. stock colony. Animals were

randomly assigned to treatment groups using a computer program. The study was

conducted according the protocol and WIL standard operating procedures.

ENVIRONMENTAL CONDITIONS:

The animals were housed and maintained under conditions consistent with maintaining

good health. Temperature and relative humidity were set to maintain at 71 ± 5° C and

30-70%, respectively, in a room with a 12 hour light (6 a.m. to 6 p.m.)/dark photoperiod.

Temperature and relative humidity were recorded once daily. The facilities at WIL

Research Laboratories, Inc. are fully accredited by the Association for Assessment and

Accreditation of Laboratory Animal Care International (AAALAC International).

VIABILITY OBSERVATIONS:

The rats were observed for mortality/moribundity and general condition twice daily, in

the morning and in the afternoon.

BODY WEIGHTS:

Body weights were recorded on days of dosing for calculation of doses only.

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FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS:

The Functional Observational Battery used at WIL Research Laboratories, Inc. is based

on previously developed protocols (Moser et al., 1999; Irwin, 1968; Gad, 1982; Moser et

al., 1988; Haggerty, 1989; O’Donoghue, 1989). Testing for Phase III (described below)

was performed by trained technicians who did not know the animal’s group assignment.

The time of testing was determined by the Study Director based on the appearance of the

expected behavioral signs following dosing. Animals were observed for the following

parameters as described below (see WIL standard operating procedure No. T1-112, as

revised, for a description of scoring criteria):

HOME CAGE OBSERVATIONS:

Posture Biting

Convulsions/Tremors Palpebral (eyelid) closure

Feces consistency

HANDLING OBSERVATIONS:

Ease of removal from cage Ease of handling animal in hand

Lacrimation/chromodacryorrhea Salivation

Piloerection Fur appearance

Palpebral closure Respiratory rate/character

Red/crusty deposits Mucous membranes/eye/skin color

Eye prominence Muscle tone

OPEN FIELD OBSERVATIONS: (evaluated over a 2-minute observation period)

Mobility Gait

Rearing Arousal

Convulsions/tremors Urination/defecation

Grooming Gait score

Bizarre/stereotypic behavior Backing

Time to first step (seconds)

SENSORY OBSERVATIONS:

Approach response Touch response

Startle response Tail pinch

Pupil response Eyeblink response

Forelimb extension Hindlimb extension

Air righting reflex Olfactory orientation

The study design consisted of three distinct phases to ensure the most adequate training

and reliability among the technicians. Phases were designed as a progression to allow for

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training and discussion prior to the final phase, which evaluated the inter-observer

reliability. The phases of testing are described as follows:

PHASE I:

Phase I testing consisted of FOB assessments on naive stock animals. Each

technician observed up to 60 rats through the entire FOB assessment. The purpose of

Phase I testing was to ensure consistent and accurate use of all equipment and to gain

a strong knowledge of the stereotypic behavior of naive animals. All rats used in

Phase I testing were returned to stock following FOB assessments.

PHASE II:

Phase II testing consisted of an open discussion of each animal’s observations

conducted in a group setting. Two animals per group were dosed with Parathion,

IDPN or deionized water and evaluated by the observers once the effects were

apparent. Phase II allowed for open discussion of observations and interpretation of

the findings. All animals used in Phase II testing were euthanized by carbon dioxide

inhalation and carcasses discarded following testing.

PHASE III:

Phase III testing consisted of three animals per group dosed with a single dose of

Parathion, IDPN or deionized water and observed at a time determined by the Study

Director. Each technician individually recorded observations for each animal to

evaluate the inter-observer reliability. All animals used in Phase III testing were

euthanized by carbon dioxide inhalation and carcasses discarded following testing.

CRITERIA FOR EVALUATION OF TECHNICIANS:

The following criteria were used to evaluate the ability of technicians to reliably

distinguish signs of neurotoxicity.

1. No omission of findings within the categories of Home Cage Observations,

Handling Observations, Open Field Observations and Sensory Observations.

2. A difference of no more than two grades (severity) for a given finding in each

category.

RESULTS:

VIABILITY:

All animals survived until scheduled euthanasia.

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FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS:

Technicians were consistent in the findings reported when deionized water, IDPN or

Parathion was administered (Table 1). There were no obvious or gross

inconsistencies among the calls.

It was determined that the previously established criteria for evaluation were fulfilled

to a degree deemed acceptable by the Study Director. It should be noted that there

were a few apparent omissions of findings (Table 2) which upon further review were

found to be of no practical significance.

CONCLUSIONS:

It was determined that the technicians fulfilled the criteria for reliably observing FOB

parameters to assess behavioral changes in rats in a manner consistent with good science

and WIL Research Laboratories, Inc. standard operating procedures.

REFERENCES:

Gad, S.C. A neuromuscular screen for use in industrial toxicology. Journal of

Toxicology and Environmental Health 1982, 9(5-6), 691-704.

Haggerty, G.C. Development of tier I neurobehavioral testing capabilities for

incorporation into pivotal rodent safety assessment studies. Journal of the American

College of Toxicology 1989, 8(1), 53-69.

Irwin, S. Comprehensive observational assessment: Ia. a systematic, quantitative

procedure for assessing the behavioral and physiologic state of the mouse.

Psychopharmacologia 1968, 13, 222-257.

Moser, V.C.; McCormick, J.P.; Creason, J.P.; MacPhail, R.C. Comparison of

chlordimeform and carbaryl using a functional observational battery. Fundamentals

of Applied Toxicology 1988, 11(2), 189-206.

Moser, V.C.; McDaniel, K.L.; Phillips, P.M. Rat strain and stock comparisons using

a functional observational battery: baseline values and effects of amitraz.

Toxicology and Applied Pharmacology 1991, 108(2), 267-283.

O’Donoghue, J.L. (1989) Screening for neurotoxicity using a neurologically based

examination and neuropathology. J. Amer. Coll. Toxicol. 8:97-116.

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 WIL-99263 TABLE 1

FOB OBSERVATIONS - NO. OF OCCURRENCES OF FINDINGS

PAGE 1

TREATMENT:

TECHNICIAN GRG MJM TAP AZ GRG MJM TAP AZ GRG MJM TAP AZ

POSTURE 1 - SITTING OR STANDING NORMALLY 1 2 12 3 2 32 2 - ASLEEP, LYING ON SIDE OR CURLED UP 2 1 2 1 3 3 3 3 3 - ALERT, ORIENTED TOWARD OBSERVER 1 1 4 - SITTING, HEAD HELD LOW 5 - FLATTENED, LIMBS MAY BE EXTENDED 6 - LYING ON SIDE, LIMBS IN AIR 7 - IMMOBILE 8 - REARING 9 - SPLAYED HINDLEGS10 - PROSTRATIONCONVULSIONS - CLONIC 1 - ABSENT 3 3 33 3 3 33 2 3 33 2 - TWITCHES (BACK MUSCLES) 3 - IRREGULAR JERKING MOVEMENTS OF THE LIMBS 4 - CLONIC WHOLE-BODY CONVULSIONS 5 - HEAD AND/OR BODY TWITCHES (MYOCLONUS) 6 - MUSCLE FASICULATIONS 7 - REPETITIVE MOVEMENT OF MOUTH AND JAWS (CHEWING)CONVULSIONS - TONIC 1 - ABSENT 3 3 33 3 3 33 3 3 33 2 - TONIC: CONTRACTION OF EXTENSORS SUCH THAT LIMBS ARE RIGID AND EXTENDED 3 - OPISTHOTONUS: HEAD, BODY AND LIMBS RIGIDLY ARCHED BACKWARDS 4 - EMPROSTHOTONUS: HEAD, BODY AND LIMBS EXTENDED FORWARD 5 - 'POPCORN SEIZURE': ANIMAL REPEATEDLY JUMPS OR BOUNCES IN AIR 6 - ASPHYXIAL: BOUTS OF SEVERE CLONIC-TONIC CONVULSIONSTREMORS 1 - NONE 3 3 33 3 3 33 3 3 33 2 - SLIGHT (1.5mm) 3 - MODERATELY COARSE (3 mm) 4 - MARKEDLY COARSE (4.5mm) 5 - EXTREMELY COARSE (6 mm)

CONTROL IDPN Parathion

 Counts indicate the number of animals observed with a particular finding.

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 WIL-99263 TABLE 1

FOB OBSERVATIONS - NO. OF OCCURRENCES OF FINDINGS

PAGE 2

TREATMENT:

TECHNICIAN GRG MJM TAP AZ GRG MJM TAP AZ GRG MJM TAP AZ

CONTROL IDPN Parathion

BITING 1 - NONE 3 3 33 3 3 33 3 2 33 2 - BITING OF CAGE 3 - BITING OF SELFPALPEBRAL CLOSURE 1 - EYELIDS WIDE OPEN 1 2 12 2 3 33 2 - EYELIDS SLIGHTLY DROOPING 1 3 - DROOPING EYELIDS (HALF-CLOSED) 4 - EYELIDS COMPLETELY SHUT 2 1 21 3 3 33FECES CONSISTENCY 1 - PELLETS 2 2 22 2 - PELLETS, PARTIALLY FORMED 1 1 11 3 - UNFORMED, DIARRHEA 4 - PELLETS ABSENT 3 3 33 3 3 33EASE OF REMOVAL1 - VERY EASY: ANIMAL SITS QUIETLY, ALLOWS INVESTIGATOR TO PICK IT UP 2 2 212 - EASY: WITH/WITHOUT VOCALIZATION, WITHOUT RESISTANCE OR SLIGHT RESISTANCE 3 3 3 3 2 2 2 1 13 - MODERATELY DIFFICULT: ANIMAL REARS, OFTEN FOLLOWING THE INVESTIGATOR'S HAND 1 1 1 1 1 1 1 14 - FREEZES: WITH/WITHOUT VOCALIZATION5 - DIFFICULT: RUNS AROUND CAGE, IS HARD TO GRAB, WITH/WITHOUT VOCALIZATION6 - VERY DIFFICULT: TAIL AND THROAT RATTLES WITH/WITHOUT VOCALIZATION; MAY ATTACKEASE OF HANDLING IN HAND 1 - LOW: NO RESISTANCE, ANIMAL IS EASY TO HANDLE 2 1 2 1 1 1 1 2 - MODERATELY LOW: SLIGHT RESISTANCE TO BEING HANDLED, WITH/WITHOUT VOCALIZATION 1 2 1 2 2 2 2 2 2 2 3 2 3 - MODERATELY HIGH: MAY FREEZE, BE TENSE OR RIGID, WITH/WITHOUT VOCALIZATION 1 1 1 1 4 - HIGH: SQUIRMS, TWISTS, ATTEMPTS TO BITE, WITH/WITHOUT VOCALIZATIONLACRIMATION 1 - NONE 3 3 33 2 2 22 3 3 33 2 - SLIGHT 1 1 11 3 - SEVERECHROMODACRYORRHEA 1 - ABSENT 3 3 33 3 3 33 3 3 33 2 - PRESENT

 Counts indicate the number of animals observed with a particular finding.

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 WIL-99263 TABLE 1

FOB OBSERVATIONS - NO. OF OCCURRENCES OF FINDINGS

PAGE 3

TREATMENT:

TECHNICIAN GRG MJM TAP AZ GRG MJM TAP AZ GRG MJM TAP AZ

CONTROL IDPN Parathion

SALIVATION 1 - NONE 3 3 33 3 3 33 3 3 33 2 - SLIGHT 3 - SEVEREPILOERECTION 1 - NONE 3 3 33 3 3 33 3 3 33 2 - SLIGHT 3 - SEVEREFUR APPEARANCE 1 - NORMAL: CLEAN AND GROOMED 3 3 33 3 3 33 2 2 22 2 - SLIGHTLY SOILED 1 1 11 3 - VERY SOILED, CRUSTYPALPEBRAL CLOSURE 1 - EYELIDS WIDE OPEN 3 3 33 2 2 22 3 3 33 2 - EYELIDS SLIGHTLY DROOPING 1 1 11 3 - DROOPING EYELIDS (HALF-CLOSED) 4 - EYELIDS COMPLETELY SHUTRESPIRATORY RATE 1 - NORMAL: BY OBSERVATION (80-110/MIN.) 3 3 3 3 3 3 3 3 3 3 3 3 2 - DECREASED: BELOW 80/MIN. 3 - INCREASED: ABOVE 110/MIN.RESPIRATORY CHARACTER 1 - NORMAL 3 3 33 3 3 23 3 3 33 2 - RALES: ABNORMAL SOUND ACCOMPANYING BREATHING 3 - RETCHING 4 - DYSPNEIC: SHORT OF BREATH 5 - GASPINGRED DEPOSITS - eyes 1 - PRESENT 2 - ABSENT 3 3 33 3 3 33 3 3 33RED DEPOSITS - nose 1 - PRESENT 1 1 11 2 - ABSENT 3 3 33 3 3 33 2 2 22

 Counts indicate the number of animals observed with a particular finding.

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 WIL-99263 TABLE 1

FOB OBSERVATIONS - NO. OF OCCURRENCES OF FINDINGS

PAGE 4

TREATMENT:

TECHNICIAN GRG MJM TAP AZ GRG MJM TAP AZ GRG MJM TAP AZ

CONTROL IDPN Parathion

RED DEPOSITS - mouth 1 - PRESENT 2 - ABSENT 3 3 33 3 3 33 3 3 33CRUSTY DEPOSITS - eyes 1 - PRESENT 2 - ABSENT 3 3 33 3 3 33 3 3 33CRUSTY DEPOSITS - nose 1 - PRESENT 2 - ABSENT 3 3 33 3 3 33 3 3 33CRUSTY DEPOSITS - mouth 1 - PRESENT 2 - ABSENT 3 3 33 3 3 33 3 3 33MUCOUS MEMBRANES - color 1 - PINK 3 3 33 3 3 33 3 3 33 2 - PALE 3 - DARKENED 4 - DARKENED, BROWN 5 - BRIGHT, DEEP RED FLUSHEYES - color 1 - PINK 3 3 33 3 3 33 3 3 33 2 - PALE 3 - DARKENED 4 - DARKENED, BROWN 5 - BRIGHT, DEEP RED FLUSHSKIN - color 1 - PINK 3 3 33 3 3 33 3 3 33 2 - PALE 3 - DARKENED 4 - DARKENED, BROWN 5 - BRIGHT, DEEP RED FLUSH

 Counts indicate the number of animals observed with a particular finding.

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 WIL-99263 TABLE 1

FOB OBSERVATIONS - NO. OF OCCURRENCES OF FINDINGS

PAGE 5

TREATMENT:

TECHNICIAN GRG MJM TAP AZ GRG MJM TAP AZ GRG MJM TAP AZ

CONTROL IDPN Parathion

EYE PROMINENCE 1 - NORMAL 3 3 33 3 3 33 3 3 33 2 - EXOPHTHALMUS 3 - ENOPHTHALMUSMUSCLE TONE 1 - MUSCLE IS FIRM BUT NOT HARD (NORMAL) 2 2 2 2 3 3 3 3 1 1 1 1 2 - MUSCLE IS SOFT AND FLABBY 1 1 11 3 - MUSCLE IS TENSE AND HARD 1 1 11 1 1 11TIME TO FIRST STEP (seconds) REQUIRES NUMERICAL INPUTMOBILITY 1 - NORMAL 3 3 33 3 3 33 2 - SLIGHTLY IMPAIRED 3 3 33 3 - MODERATELY IMPAIRED 4 - TOTALLY IMPAIRED, LOCOMOTION IMPOSSIBLEGAIT 1 - NORMAL 3 3 33 2 2 11 2 - WALKS ON TIPTOES 1 1 21 3 - BODY DRAGS, ABDOMEN CONTACTS SURFACE, BODY SWAYS 4 - HINDLIMBS SPLAYED OR DRAGGING, UNABLE TO SUPPORT WEIGHT 2 3 3 3 1 5 - HUNCHED BODY 2 3 33 1 1 11 6 - ATAXIA, EXCESSIVE SWAY, ROCKS OR LURCHES AS PROCEEDS FORWARD 3 2 2 3 7 - WALKS ON METATARSUSCONVULSIONS - CLONIC 1 - ABSENT 3 3 33 2 2 12 3 3 332- TWITCHES (BACK MUSCLES) 3 - REPETITIVE MOVEMENT OF MOUTH AND JAWS 1 1 21 4 - CLONIC TREMORS OF THE LIMBS 5 - WHOLE BODY TREMORS 6 - CLONIC CONVULSIONS 7 - WET DOG SHAKES

 Counts indicate the number of animals observed with a particular finding.

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 WIL-99263 TABLE 1

FOB OBSERVATIONS - NO. OF OCCURRENCES OF FINDINGS

PAGE 6

TREATMENT:

TECHNICIAN GRG MJM TAP AZ GRG MJM TAP AZ GRG MJM TAP AZ

CONTROL IDPN Parathion

CONVULSIONS - TONIC 1 - ABSENT 3 3 33 3 3 33 3 3 33 2 - TONIC: CONTRACTION OF EXTENSORS SUCH THAT LIMBS ARE RIGID AND EXTENDED 3 - OPISTHOTONUS: HEAD, BODY AND LIMBS RIGIDLY ARCHED BACKWARDS 4 - EMPROSTHOTONUS: HEAD, BODY AND LIMBS EXTENDED FORWARD 5 - 'POPCORN SEIZURE': ANIMAL REPEATEDLY JUMPS OR BOUNCES IN AIR 6 - ASPHYXIAL: BOUTS OF SEVERE CLONIC-TONIC CONVULSIONSTREMORS 1 - NONE 3 3 33 3 3 33 3 3 33 2 - SLIGHT (1.5mm) 3 - MODERATELY COARSE (3 mm), SLIGHT IMPAIRMENT OF LOCOMOTION 4 - MARKEDLY COARSE (4.5mm), MODERATE/MARKED IMPAIRMENT OF LOCOMOTION 5 - EXTREMELY COARSE (6 mm), LOCOMOTION IMPOSSIBLEGAIT SCORE 1 - NORMAL 3 3 33 2 2 22 2 - SLIGHT IMPAIRMENT, BUT DEFINITE 3 3 33 1 1 11 3 - CONSIDERABLE IMPAIRMENT, WITHOUT FALLING 4 - MARKED IMPAIRMENT, FALLS EVERY 4 TO 6 STEPS 5 - SEVERE IMPAIRMENT, CANNOT WALK WITHOUT FALLINGAROUSAL 1 - VERY LOW: STUPOR, COMA, LITTLE OR NO RESPONSIVENESS 2 - LOW: SOMEWHAT STUPOROUS 1 3 - NORMAL: ALERT, EXPLORATORY MOVEMENTS 3 3 3 3 3 2 2 3 3 3 3 3 4 - SOMEWHAT HIGH: SLIGHT EXCITEMENT, TENSE, SUDDEN DARTING OR FREEZING 1 5 - VERY HIGH: HYPERALERT, EXCITED, SUDDEN BOUTS OF RUNNING OR BODY MOVEMENTS

 Counts indicate the number of animals observed with a particular finding.

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 WIL-99263 TABLE 1

FOB OBSERVATIONS - NO. OF OCCURRENCES OF FINDINGS

PAGE 7

TREATMENT:

TECHNICIAN GRG MJM TAP AZ GRG MJM TAP AZ GRG MJM TAP AZ

CONTROL IDPN Parathion

BIZARRE/STEREOTYPIC BEHAVIOR 1 - NONE 3 3 33 2 2 22 2 - HEAD FLICK: HEAD SHAKING OR BACKWARD FLIP OF HEAD 3 3 23 3 - HEAD SEARCH: STEREOTYPED, REPETITIVE TURNING OF HEAD FROM SIDE TO SIDE 3 3 3 3 4 - HALLUCINATORY: APPEARS TO BE RESPONDING TO OBJECTS NOT PRESENT 5 - COMPULSIVE LICKING OR BITING 6 - PRANCING: RESTLESS SHIFTING FROM ONE FORELIMB TO THE OTHER 7 - UPRIGHT WALKING: ON HINDLIMBS ONLY 8 - AIMLESS WANDERING: PROGRESSIVE, SLOW, PLODDING MOVEMENTS, NO APPARENT PURPOSE 9 - CIRCLING: TENDENCY TO MOVE IN CIRCLES AROUND OBJECTS, OR IN AN OPEN ENVIRONMENT 2 2 2 210 - WALTZING: RAPID TURNING IN CIRCLES11 - RETROPULSION: ANIMAL WALKS BACKWARDS 1 2 22 1 1 1112 - SPATIAL DISORIENTATION: WALKING OR STUMBLING INTO OBJECTS13 - SIDE TO SIDE ROCKING14 - STRAUB TAIL: INCREASED TAIL ELEVATION15 - VERTICAL JUMPING16 - PACING WITHOUT PURPOSE17 - HEAD BOBBING18 - WRITHING: LYING DOWN, WAVELIKE MOVEMENTS OF ABDOMEN, ALTERNATING LIMB MOVEMENTSREARING REQUIRES NUMERICAL INPUT 17 17 17 17 1 1 1 1 13 13 13 13BACKING REQUIRES NUMERICAL INPUT 0 0 00 4 4 44 2 2 22GROOMING REQUIRES NUMERICAL INPUT 3 3 33 1 1 11 2 2 22URINATION REQUIRES NUMERICAL INPUT 0 0 00 1 1 11 1 1 11DEFECATION REQUIRES NUMERICAL INPUT 1 1 11 0 0 00 0 0 00

 Counts indicate the number of animals observed with a particular finding.

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 WIL-99263 TABLE 1

FOB OBSERVATIONS - NO. OF OCCURRENCES OF FINDINGS

PAGE 8

TREATMENT:

TECHNICIAN GRG MJM TAP AZ GRG MJM TAP AZ GRG MJM TAP AZ

CONTROL IDPN Parathion

APPROACH RESPONSE 1 - NO REACTION 1 1 11 2 - SLOW APPROACH, SNIFFING OR TURNING AWAY 2 2 2 2 3 3 3 3 3 3 2 3 3 - MORE ENERGETIC RESPONSE THAN (2), WITH/WITHOUT VOCALIZATION 1 4 - FREEZES, ACTUAL MUSCLE CONTRACTION 5 - BIZARRE REACTION: JUMPS, BITES OR ATTACKSTOUCH RESPONSE 1 - NO REACTION 2 - ANIMAL MAY SLOWLY TURN, WALK AWAY 2 2 2 2 3 3 3 3 3 3 3 3 3 - MORE ENERGETIC RESPONSE THAN (2), WITH/WITHOUT VOCALIZATION 1 1 1 1 4 - FREEZES, ACTUAL MUSCLE CONTRACTION 5 - BIZARRE REACTION: JUMPS, BITES OR ATTACKSSTARTLE RESPONSE 1 - NO REACTION 3 3 33 2 - SLIGHT REACTION, EAR FLICK OR SOME EVIDENCE THAT SNAP WAS HEARD 3 3 2 3 1 2 1 2 3 - MORE ENERGETIC RESPONSE THAN (2), WITH/WITHOUT VOCALIZATION 1 2 1 2 1 4 - FREEZES, ACTUAL MUSCLE CONTRACTION 5 - BIZARRE REACTION: JUMPS, BITES OR ATTACKSTAIL PINCH RESPONSE 1 - NO REACTION 2 - ANIMAL MAY SLOWLY TURN, WALK AWAY 2 2 2 2 3 3 3 3 2 2 2 2 3 - MORE ENERGETIC RESPONSE THAN (2), WITH/WITHOUT VOCALIZATION 1 1 1 1 1 1 1 1 4 - FREEZES, ACTUAL MUSCLE CONTRACTION 5 - BIZARRE REACTION: JUMPS, BITES OR ATTACKSOLFACTORY ORIENTATION 1 - NO REACTION PRESENT 2 - REACTION PRESENT: ANIMAL APPROACHES SWAB MAKING SNIFFING MOVEMENTS WITH NOSE 3 3 3 3 3 3 3 3 3 3 3 3PUPIL RESPONSE 1 - NO PUPIL RESPONSE 3 3 33 2 - PUPIL RESPONSE PRESENT 3 3 33 3 3 33EYEBLINK RESPONSE 1 - NO EYEBLINK RESPONSE 2 - EYEBLINK RESPONSE PRESENT 3 3 33 3 3 33 3 3 33

 Counts indicate the number of animals observed with a particular finding.

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FOB OBSERVATIONS - NO. OF OCCURRENCES OF FINDINGS

PAGE 9

TREATMENT:

TECHNICIAN GRG MJM TAP AZ GRG MJM TAP AZ GRG MJM TAP AZ

CONTROL IDPN Parathion

FORELIMB EXTENSION 1 - NO FORELIMB EXTENSION 2 2 22 2 - FORELIMB EXTENSION PRESENT 3 3 33 1 1 11 3 3 33HINDLIMB EXTENSION 1 - NO HINDLIMB EXTENSION 3 3 33 2 2 11 2 - HINDLIMB EXTENSION PRESENT 3 3 33 1 1 22AIR RIGHTING REFLEX 1 - NORMAL 3 3 33 3 3 33 2 - SLIGHTLY UNCOORDINATED 1 1 11 3 - LANDS ON SIDE 1 1 11 4 - LANDS ON BACK 1 1 11

 Counts indicate the number of animals observed with a particular finding.

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TABLE 2

FOB OBSERVATIONS – FINDINGS OMITTED

TECHNICIAN TREATMENT CATEGORY OMITTED

TAP IDPN RESPIRATORY CHARACTER

AZ IDPN EASE OF REMOVAL

GRG PARATHION CONVULSIONS – CLONIC

MJM PARATHION BITING

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WIL-99310

AN INTER-OBSERVER RELIABILITY STUDY OF INDIVIDUALS

ASSIGNED TO PERFORM FUNCTIONAL OBSERVATIONAL

BATTERY OBSERVATIONS FOR NEUROTOXICITY STUDIES

Study Date Range: April 13-29, 2004

STUDY OBJECTIVE:

The objective of this study was to train personnel to conduct the Functional

Observational Battery (FOB) and to assess inter-observer reliability of the same

individuals. The inter-observer reliability also included one individual that had been

previously trained to further demonstrate inter-observer reliability of the newly trained

individuals with those currently approved to conduct neurotoxicity studies. FOB

inter-observer reliability studies serve as training for new employees, as well as on-going

training for current employees.

CONTROL ARTICLES:

Mazola® corn oil was used as the negative control article. Three positive control articles,

3,3 ́-Iminodipropionitrile (IDPN), Parathion and d-Amphetamine, were used to elicit

behavioral changes in the animals. IDPN was administered orally (gavage) at

2000 mg/kg, Parathion was administered orally (gavage) at 4 mg/kg, and d-Amphetamine

was administered by intraperitoneal injection at 2 mg/kg. All positive and negative

control articles were administered as a single dose.

TEST SYSTEM:

All animals used on the study were female Sprague-Dawley Crl:CD® (SD)IGS BR rats

obtained from the WIL Research Laboratories, Inc. stock colony. Animals were

randomly assigned to treatment groups using a computer program. The study was

conducted according the protocol and WIL standard operating procedures.

ENVIRONMENTAL CONDITIONS:

The animals were housed and maintained under conditions consistent with maintaining

good health. Temperature and relative humidity were set to maintain at 71 ± 5° C and

30-70%, respectively, in a room with a 12 hour light (6 a.m. to 6 p.m.)/dark photoperiod.

Temperature and relative humidity were recorded once daily. The ventilation rate was set

at a minimum of 10 room air changes per hour using 100% fresh air. The facilities at

WIL Research Laboratories, Inc. are fully accredited by the Association for Assessment

and Accreditation of Laboratory Animal Care International (AAALAC International).

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VIABILITY OBSERVATIONS:

The rats were observed for mortality/moribundity and general condition twice daily, in

the morning and in the afternoon.

BODY WEIGHTS:

Body weights were recorded on days of dose administration for calculation of doses only.

FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS:

The Functional Observational Battery used at WIL Research Laboratories, Inc. is based

on previously developed protocols (Moser et al., 1999; Irwin, 1968; Gad, 1982; Moser et

al., 1988; Haggerty, 1989; O’Donoghue, 1989). Testing for the Inter-observer Reliability

testing (described below) was performed by trained technicians who did not know the

animal’s group assignment. The time of testing was determined by the Study Director

based on the appearance of the expected behavioral signs following dosing. Animals

were observed for the following parameters as described below (see WIL standard

operating procedure No. T1-112, as revised, for a description of scoring criteria):

HOME CAGE OBSERVATIONS:

Posture Biting

Convulsions/Tremors Palpebral (eyelid) closure

Feces consistency

HANDLING OBSERVATIONS:

Ease of removal from cage Ease of handling animal in hand

Lacrimation/chromodacryorrhea Salivation

Piloerection Fur appearance

Palpebral closure Respiratory rate/character

Red/crusty deposits Mucous membranes/eye/skin color

Eye prominence Muscle tone

OPEN FIELD OBSERVATIONS: (evaluated over a 2-minute observation period)

Mobility Gait

Rearing Arousal

Convulsions/tremors Urination/defecation

Grooming Gait score

Bizarre/stereotypic behavior Backing

Time to first step (seconds)

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WIL-99310

SENSORY OBSERVATIONS:

Approach response Touch response

Startle response Tail pinch

Pupil response Eyeblink response

Forelimb extension Hindlimb extension

Air righting reflex Olfactory orientation

The study design consisted of three distinct phases to ensure the most adequate training

and reliability among the technicians. Phases were designed as a progression to allow for

training and discussion prior to the final phase, which evaluated the inter-observer

reliability. The phases of testing are described as follows:

PHASE I:

Phase I testing consisted of FOB assessments on naive stock animals. Each

technician observed up to 60 rats through the entire FOB assessment. The purpose of

Phase I testing was to ensure consistent and accurate use of all equipment and to gain

a strong knowledge of the stereotypic behavior of naive animals. All rats used in

Phase I testing were returned to stock following FOB assessments.

PHASE II:

Phase II testing consisted of an open discussion of each animal’s observations

conducted in a group setting. Two animals per group were dosed with IDPN,

Parathion, d-Amphetamine or corn oil and evaluated by the observers once the effects

were apparent. Phase II allowed for open discussion of observations and

interpretation of the findings. All animals used in Phase II testing were euthanized by

carbon dioxide inhalation and carcasses discarded following testing.

PHASE III:

Inter-observer Reliability testing consisted of three animals per group dosed with a

single dose of Parathion, IDPN, d-Amphetamine or corn oil and observed at a time

determined by the Study Director or designee. Each observer individually recorded

observations for each animal to evaluate the inter-observer reliability. All animals

used in Inter-observer Reliability testing were euthanized by carbon dioxide

inhalation and carcasses discarded following testing.

CRITERIA FOR EVALUATION OF TECHNICIANS:

The following criteria were used to evaluate the ability of technicians to reliably

distinguish signs of neurotoxicity.

1. No omission of findings within the categories of Home Cage Observations,

Handling Observations, Open Field Observations and Sensory Observations.

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2. A difference of no more than two grades (severity) for a given finding in each

category.

RESULTS:

VIABILITY:

All animals survived until scheduled euthanasia.

FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS:

Observers B, C, D and E were consistent in the findings reported when corn oil,

IDPN, Parathion or d-Amphetamine was administered (Table 1). There were no

obvious or gross inconsistencies among the calls with the exception of observer E

who differed consistently when evaluating pupillary response. Therefore, these four

observers were considered to have met acceptable for performing the functional

observational battery on neurotoxicity studies. However, prior to working

independently on studies, observer E will undergo additional training and

demonstrate proficiency in the evaluation of pupillary response.

Observer A differed significantly from the common response of the other observers in

several categories. Therefore, observer A was not considered to have met acceptable

criteria for performing functional observational battery testing on neurotoxicity

studies.

It should be noted there were six apparent omissions of observations (Table 2) which

upon further review were found to be of no consequence.

REFERENCES:

Gad, S.C. A neuromuscular screen for use in industrial toxicology. Journal of

Toxicology and Environmental Health 1982, 9(5-6), 691-704.

Haggerty, G.C. Development of tier I neurobehavioral testing capabilities for

incorporation into pivotal rodent safety assessment studies. Journal of the American

College of Toxicology 1989, 8(1), 53-69.

Irwin, S. Comprehensive observational assessment: Ia. a systematic, quantitative

procedure for assessing the behavioral and physiologic state of the mouse.

Psychopharmacologia 1968, 13, 222-257.

Moser, V.C.; McCormick, J.P.; Creason, J.P.; MacPhail, R.C. Comparison of

chlordimeform and carbaryl using a functional observational battery. Fundamentals

of Applied Toxicology 1988, 11(2), 189-206.

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Moser, V.C.; McDaniel, K.L.; Phillips, P.M. Rat strain and stock comparisons using

a functional observational battery: baseline values and effects of amitraz.

Toxicology and Applied Pharmacology 1991, 108(2), 267-283.

O’Donoghue, J.L. (1989) Screening for neurotoxicity using a neurologically based

examination and neuropathology. J. Amer. Coll. Toxicol. 8:97-116.

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 WIL-99310 TABLE 1

FOB2 - INTEROBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

POSTURE

 1 - SITTING OR STANDING NORMALLY X XXXX XX X X 2 - ASLEEP, LYING ON SIDE OR CURLED UP X 3 - ALERT, ORIENTED TOWARD OBSERVER X XX XXXXXX XXXXXXXXX 4 - SITTING, HEAD HELD LOW X X 5 - FLATTENED, LIMBS MAY BE EXTENDED 6 - LYING ON SIDE, LIMBS IN AIR 7 - IMMOBILE 8 - REARING X X9 - SPLAYED HINDLEGS10 - PROSTRATIONCONVULSIONS - CLONIC 1 - ABSENT XXXXXXXXXXXXXXXXXXX XXXXXXXXXX 2 - TWITCHES (BACK MUSCLES) 3 - IRREGULAR JERKING MOVEMENTS OF THE LIMBS 4 - CLONIC WHOLE-BODY CONVULSIONS 5 - HEAD AND/OR BODY TWITCHES (MYOCLONUS) X 6 - MUSCLE FASICULATIONS(CHEWING)CONVULSIONS - TONIC 1 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - TONIC: CONTRACTION OF EXTENSORS SUCH THAT LIMBS ARE RIGID AND EXTENDEDARCHED BACKWARDSEXTENDED FORWARD 5 - 'POPCORN SEIZURE': ANIMAL REPEATEDLY JUMPS OR BOUNCES IN AIR 6 - ASPHYXIAL: BOUTS OF SEVERE CLONIC-TONIC CONVULSIONS

Animal #52315 Animal #52210 Animal #52321 Animal #52298 Animal #52277 Animal #52222

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 WIL-99310 TABLE 1

FOB2 - INTEROBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

POSTURE

TREMORS 1 - ABSENT XXXXXXXXXXXXXXX XXXXXXXXX XXXX 2 - SLIGHT (1.5mm) X X 3 - MODERATELY COARSE (3 mm) 4 - MARKEDLY COARSE (4.5mm) 5 - EXTREMELY COARSE (6 mm)BITING 1 - NONE XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - BITING OF CAGE 3 - BITING OF SELFPALPEBRAL CLOSURE 1 - EYELIDS WIDE OPEN XX XXXXXXXXXXXXXXXXXXXXXXXXX 2 - EYELIDS SLIGHTLY DROOPING X XX 3 - DROOPING EYELIDS (HALF-CLOSED) 4 - EYELIDS COMPLETELY SHUTFECES CONSISTENCY 1 - PELLETS XXXXXXXXXXXXXXXXXXXXXXXXX XXXX 2 - PELLETS, PARTIALLY FORMED 3 - UNFORMED, DIARRHEA 4 - PELLETS ABSENTEASE OF HANDLING IN HAND 1 - LOW: NO RESISTANCE, ANIMAL IS EASY TO HANDLE XXXXXXX XXXXXX XXXXXXXXXXXXXXX 2 - MODERATELY LOW: SLIGHT RESISTANCE TO BEING HANDLED, WITH/WITHOUT VOCALIZATION X X 3 - MODERATELY HIGH: MAY FREEZE, BE TENSE OR RIGID, WITH/WITHOUT VOCALIZATION 4 - HIGH: SQUIRMS, TWISTS, ATTEMPTS TO BITE, WITH/WITHOUT VOCALIZATIONLACRIMATION 1 - NONE XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - SLIGHT 3 - SEVERECHROMODACRYORRHEA 1 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - PRESENT

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 WIL-99310 TABLE 1

FOB2 - INTEROBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

POSTURE

SALIVATION 1 - NONE XXXXXXXXXXXXXXX XXXXXXXXXXXXXX 2 - SLIGHT X 3 - SEVEREPILOERECTION 1 - NONE XXXXXXXXXX XXX XXXXXXXXXX XX 2 - SLIGHT X X X XX 3 - SEVEREFUR APPEARANCE 1 - NORMAL: CLEAN AND GROOMED XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - SLIGHTLY SOILED 3 - VERY SOILED, CRUSTYPALPEBRAL CLOSURE 1 - EYELIDS WIDE OPEN XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - EYELIDS SLIGHTLY DROOPING 3 - DROOPING EYELIDS (HALF-CLOSED) 4 - EYELIDS COMPLETELY SHUTRESPIRATORY RATE 1 - NORMAL: BY OBSERVATION (80-110/MIN.) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - DECREASED: BELOW 80/MIN. 3 - INCREASED: ABOVE 110/MIN.RESPIRATORY CHARACTER 1 - NORMAL XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - RALES: ABNORMAL SOUND ACCOMPANYING BREATHING 3 - RETCHING 4 - DYSPNEIC: SHORT OF BREATH 5 - GASPINGRED DEPOSITS - eyes 1 - PRESENT 2 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRED DEPOSITS - nose 1 - PRESENT X 2 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXX XXX

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 WIL-99310 TABLE 1

FOB2 - INTEROBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

POSTURE

RED DEPOSITS - mouth 1 - PRESENT 2 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCRUSTY DEPOSITS - eyes 1 - PRESENT 2 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCRUSTY DEPOSITS - nose 1 - PRESENT 2 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCRUSTY DEPOSITS - mouth 1 - PRESENT 2 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMUCOUS MEMBRANES - color 1 - PINK XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - PALE 3 - DARKENED 4 - DARKENED, BROWN 5 - BRIGHT, DEEP RED FLUSHEYES - color 1 - PINK XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - PALE 3 - DARKENED 4 - DARKENED, BROWN 5 - BRIGHT, DEEP RED FLUSHSKIN - color 1 - PINK XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - PALE 3 - DARKENED 4 - DARKENED, BROWN 5 - BRIGHT, DEEP RED FLUSHEYE PROMINENCE 1 - NORMAL XXXXXXXXXXXXXXX XX XXXXXXXXXXX 2 - EXOPHTHALMUS X X 3 - ENOPHTHALMUS

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 WIL-99310 TABLE 1

FOB2 - INTEROBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

POSTURE

MUSCLE TONE 1 - MUSCLE IS FIRM BUT NOT HARD (NORMAL) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - MUSCLE IS SOFT AND FLABBY 3 - MUSCLE IS TENSE AND HARDMOBILITY 1 - NORMAL XXXXXXXXXXX XXXXXXXXXXXX 2 - SLIGHTLY IMPAIRED XXXXX 3 - MODERATELY IMPAIRED 4 - TOTALLY IMPAIRED, LOCOMOTION IMPOSSIBLEGAIT 1 - NORMAL XXXX XXXXXXXXXXXXXX XX 2 - WALKS ON TIPTOES X X

 3 - BODY DRAGS, ABDOMEN CONTACTS SURFACE, BODY SWAYS 4 - HINDLIMBS SPLAYED OR DRAGGING, UNABLE TO SUPPORT WEIGHT XX X

 5 - HUNCHED BODY XX X XX XX 6 - ATAXIA, EXCESSIVE SWAY, ROCKS OR LURCHES AS PROCEEDS FORWARD XXXX 7 - WALKS ON METATARSUSCONVULSIONS - CLONIC 1 - ABSENT XXXX XXXXXXXXXXX XXXXXXXXXXXXX2- TWITCHES (BACK MUSCLES) X

 3 - REPETITIVE MOVEMENT OF MOUTH AND JAWS 4 - CLONIC TREMORS OF THE LIMBS 5 - WHOLE BODY TREMORS 6 - CLONIC CONVULSIONS 7 - WET DOG SHAKESCONVULSIONS - TONIC 1 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - TONIC: CONTRACTION OF EXTENSORS SUCH THAT LIMBS ARE RIGID AND EXTENDED 3 - OPISTHOTONUS: HEAD, BODY AND LIMBS RIGIDLY ARCHED BACKWARDS 4 - EMPROSTHOTONUS: HEAD, BODY AND LIMBS EXTENDED FORWARD

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 WIL-99310 TABLE 1

FOB2 - INTEROBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

POSTURE

 5 - 'POPCORN SEIZURE': ANIMAL REPEATEDLY JUMPS OR BOUNCES IN AIR 6 - ASPHYXIAL: BOUTS OF SEVERE CLONIC-TONIC CONVULSIONSTREMORS 1 - NONE XXXXXXXXXXXXXXXXXXXXXXXXX XXXX 2 - SLIGHT (1.5mm) X

 3 - MODERATELY COARSE (3 mm), SLIGHT IMPAIRMENT OF LOCOMOTION 4 - MARKEDLY COARSE (4.5mm), MODERATE/MARKED IMPAIRMENT OF LOCOMOTION 5 - EXTREMELY COARSE (6 mm), LOCOMOTION IMPOSSIBLE

GAIT SCORE 1 - NORMAL XXXXXXXXXXXXXXXXXXXXXXXXX 2 - SLIGHT IMPAIRMENT, BUT DEFINITE XXXX 3 - CONSIDERABLE IMPAIRMENT, WITHOUT FALLING X 4 - MARKED IMPAIRMENT, FALLS EVERY 4 TO 6 STEPS 5 - SEVERE IMPAIRMENT, CANNOT WALK WITHOUT FALLINGAROUSAL 1 - VERY LOW: STUPOR, COMA, LITTLE OR NO RESPONSIVENESS 2 - LOW: SOMEWHAT STUPOROUS X

 3 - NORMAL: ALERT, EXPLORATORY MOVEMENTS XXXXXXXXXXXXXXXXXXXXXXXX XXXXX 4 - SOMEWHAT HIGH: SLIGHT EXCITEMENT, TENSE, SUDDEN DARTING OR FREEZING 5 - VERY HIGH: HYPERALERT, EXCITED, SUDDEN BOUTS OF RUNNING OR BODY MOVEMENTS

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 WIL-99310 TABLE 1

FOB2 - INTEROBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

POSTURE

BIZARRE/STEREOTYPIC BEHAVIOR 1 - NONE XXXXXXXXXXXXXXXXXX XXXXXX

 2 - HEAD FLICK: HEAD SHAKING OR BACKWARD FLIP OF HEAD XXXXX X 3 - HEAD SEARCH: STEREOTYPED, REPETITIVE TURNING OF HEAD FROM SIDE TO SIDE X XX 4 - HALLUCINATORY: APPEARS TO BE RESPONDING TO OBJECTS NOT PRESENT

 5 - COMPULSIVE LICKING OR BITING 6 - PRANCING: RESTLESS SHIFTING FROM ONE FORELIMB TO THE OTHER 7 - UPRIGHT WALKING: ON HINDLIMBS ONLY 8 - AIMLESS WANDERING: PROGRESSIVE, SLOW, PLODDING MOVEMENTS, NO APPARENT PURPOSEBIZARRE/STEREOTYPIC BEHAVIOR (Continued) 9 - CIRCLING: TENDENCY TO MOVE IN CIRCLES AROUND OBJECTS, OR IN AN OPEN ENVIRONMENT X X X10 - WALTZING: RAPID TURNING IN CIRCLES11 - RETROPULSION: ANIMAL WALKS BACKWARDS X

12 - SPATIAL DISORIENTATION: WALKING OR STUMBLING INTO OBJECTS X

13 - SIDE TO SIDE ROCKING14 - STRAUB TAIL: INCREASED TAIL ELEVATION15 - VERTICAL JUMPING16 - PACING WITHOUT PURPOSE17 - HEAD BOBBING X X

18 - WRITHING: LYING DOWN, WAVELIKE MOVEMENTS OF ABDOMEN, ALTERNATING LIMB MOVEMENTS

PUPIL RESPONSE 1 - NO PUPIL RESPONSE XXXXX X X 2 - PUPIL RESPONSE PRESENT XXXXXXXXXXX XXXXXXXXX XXXAIR RIGHTING REFLEX 1 - NORMAL XXXXXXXXXXXXXXXXXXXXXXXXX 2 - SLIGHTLY UNCOORDINATED 3 - LANDS ON SIDE X X 4 - LANDS ON BACK XX X

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 WIL-99310 TABLE 1

FOB2 - INTER-OBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

POSTURE 1 - SITTING OR STANDING NORMALLY XX XXXXXXXXXXXXXXXXX XXXXX 2 - ASLEEP, LYING ON SIDE OR CURLED UP XXXXX 3 - ALERT, ORIENTED TOWARD OBSERVER X 4 - SITTING, HEAD HELD LOW 5 - FLATTENED, LIMBS MAY BE EXTENDED 6 - LYING ON SIDE, LIMBS IN AIR 7 - IMMOBILE 8 - REARING9 - SPLAYED HINDLEGS10 - PROSTRATIONCONVULSIONS - CLONIC 1 - ABSENT XXXXXXXXXXXXXXX XXX XXXXXXXXXX 2 - TWITCHES (BACK MUSCLES) 3 - IRREGULAR JERKING MOVEMENTS OF THE LIMBS 4 - CLONIC WHOLE-BODY CONVULSIONS 5 - HEAD AND/OR BODY TWITCHES (MYOCLONUS) X X 6 - MUSCLE FASICULATIONS 7 - REPETITIVE MOVEMENT OF MOUTH AND JAWS (CHEWING)CONVULSIONS - TONIC 1 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - TONIC: CONTRACTION OF EXTENSORS SUCH THAT LIMBS ARE RIGID AND EXTENDED 3 - OPISTHOTONUS: HEAD, BODY AND LIMBS RIGIDLY ARCHED BACKWARDS 4 - EMPROSTHOTONUS: HEAD, BODY AND LIMBS EXTENDED FORWARD 5 - 'POPCORN SEIZURE': ANIMAL REPEATEDLY JUMPS OR BOUNCES IN AIR 6 - ASPHYXIAL: BOUTS OF SEVERE CLONIC-TONIC CONVULSIONSTREMORS 1 - ABSENT XXXXXXXXXX XXXXXXXXXXXXXXXXX X 2 - SLIGHT (1.5mm) X X

 3 - MODERATELY COARSE (3 mm)

Animal #52216 Animal #52247 Animal #52225 Animal #51868 Animal #52254 Animal #52338

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 WIL-99310 TABLE 1

FOB2 - INTER-OBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

Animal #52216 Animal #52247 Animal #52225 Animal #51868 Animal #52254 Animal #52338

 4 - MARKEDLY COARSE (4.5mm) 5 - EXTREMELY COARSE (6 mm)BITING 1 - NONE XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - BITING OF CAGE 3 - BITING OF SELFPALPEBRAL CLOSURE 1 - EYELIDS WIDE OPEN XXXXXXXXXXXXXXXX X X XXXXX 2 - EYELIDS SLIGHTLY DROOPING X XX 3 - DROOPING EYELIDS (HALF-CLOSED) 4 - EYELIDS COMPLETELY SHUT XX XXFECES CONSISTENCY 1 - PELLETS X XXXXXXXXXXX XXXX XX X XXX 2 - PELLETS, PARTIALLY FORMED X X X XX 3 - UNFORMED, DIARRHEA X X X XX 4 - PELLETS ABSENTEASE OF HANDLING IN HAND 1 - LOW: NO RESISTANCE, ANIMAL IS EASY TO HANDLE XXXXXXXXXXXXXX XXXXXXXXXXXXXXX 2 - MODERATELY LOW: SLIGHT RESISTANCE TO BEING HANDLED, WITH/WITHOUT VOCALIZATION X 3 - MODERATELY HIGH: MAY FREEZE, BE TENSE OR RIGID, WITH/WITHOUT VOCALIZATION 4 - HIGH: SQUIRMS, TWISTS, ATTEMPTS TO BITE, WITH/WITHOUT VOCALIZATIONLACRIMATION 1 - NONE XXXXXXXXXX X XXXX X XXXXXX 2 - SLIGHT X XXXX X X X 3 - SEVERECHROMODACRYORRHEA 1 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - PRESENTSALIVATION 1 - NONE XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - SLIGHT 3 - SEVERE

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 WIL-99310 TABLE 1

FOB2 - INTER-OBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

Animal #52216 Animal #52247 Animal #52225 Animal #51868 Animal #52254 Animal #52338

PILOERECTION 1 - NONE XXXX XXXXXXXXXXXXXXXXXXXXXXXXX 2 - SLIGHT X 3 - SEVEREFUR APPEARANCE 1 - NORMAL: CLEAN AND GROOMED XXXXXXXXX XXXX XXX XXXXX 2 - SLIGHTLY SOILED XXXXX XX X X

 3 - VERY SOILED, CRUSTYPALPEBRAL CLOSURE 1 - EYELIDS WIDE OPEN XXXXXXXXXXXXXXXXXXX X XXXXX 2 - EYELIDS SLIGHTLY DROOPING XXX X 3 - DROOPING EYELIDS (HALF-CLOSED) X 4 - EYELIDS COMPLETELY SHUTRESPIRATORY RATE 1 - NORMAL: BY OBSERVATION (80-110/MIN.) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - DECREASED: BELOW 80/MIN. 3 - INCREASED: ABOVE 110/MIN.RESPIRATORY CHARACTER 1 - NORMAL XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - RALES: ABNORMAL SOUND ACCOMPANYING BREATHING 3 - RETCHING 4 - DYSPNEIC: SHORT OF BREATH 5 - GASPINGRED DEPOSITS - eyes 1 - PRESENT X XX 2 - ABSENT XXXXXXXXXX XXXXX XXXX XXXXXXXXRED DEPOSITS - nose 1 - PRESENT X XX X 2 - ABSENT X XXXXXXXXXXXXX XXXX XXXXXXXXRED DEPOSITS - mouth 1 - PRESENT X 2 - ABSENT XXXXXXXXXXXXXXXX XXXXXXXXXXXXXCRUSTY DEPOSITS - eyes 1 - PRESENT 2 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

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 WIL-99310 TABLE 1

FOB2 - INTER-OBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

Animal #52216 Animal #52247 Animal #52225 Animal #51868 Animal #52254 Animal #52338

CRUSTY DEPOSITS - nose 1 - PRESENT 2 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXCRUSTY DEPOSITS - mouth 1 - PRESENT 2 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXMUCOUS MEMBRANES - color 1 - PINK XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - PALE 3 - DARKENED 4 - DARKENED, BROWN 5 - BRIGHT, DEEP RED FLUSHEYES - color 1 - PINK XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - PALE 3 - DARKENED 4 - DARKENED, BROWN 5 - BRIGHT, DEEP RED FLUSHSKIN - color 1 - PINK XXXXXXXXXXXXXXX XXXXXXXXXXXXXX 2 - PALE X 3 - DARKENED 4 - DARKENED, BROWN 5 - BRIGHT, DEEP RED FLUSHEYE PROMINENCE 1 - NORMAL XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - EXOPHTHALMUS 3 - ENOPHTHALMUSMUSCLE TONE 1 - MUSCLE IS FIRM BUT NOT HARD (NORMAL) XXXX XXXXXXXXXXX X XX XXXXXXX 2 - MUSCLE IS SOFT AND FLABBY XX X X 3 - MUSCLE IS TENSE AND HARD X

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 WIL-99310 TABLE 1

FOB2 - INTER-OBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

Animal #52216 Animal #52247 Animal #52225 Animal #51868 Animal #52254 Animal #52338

MOBILITY 1 - NORMAL XXXXXXXXXXXXXXX XXXXX 2 - SLIGHTLY IMPAIRED XXX 3 - MODERATELY IMPAIRED XX XXXXX 4 - TOTALLY IMPAIRED, LOCOMOTION IMPOSSIBLEGAIT 1 - NORMAL XXX XXXXXXXXX XXX 2 - WALKS ON TIPTOES 3 - BODY DRAGS, ABDOMEN CONTACTS SURFACE, BODY SWAYS X X

 4 - HINDLIMBS SPLAYED OR DRAGGING, UNABLE TO SUPPORT WEIGHT XX XX X XX 5 - HUNCHED BODY X X XXX X XXXXX XX

 6 - ATAXIA, EXCESSIVE SWAY, ROCKS OR LURCHES AS PROCEEDS FORWARD XXX XXXX

 7 - WALKS ON METATARSUSCONVULSIONS - CLONIC 1 - ABSENT XXXXXXXXXXXXXXX XXXX XXX XXXXX2- TWITCHES (BACK MUSCLES) X 3 - REPETITIVE MOVEMENT OF MOUTH AND JAWS 4 - CLONIC TREMORS OF THE LIMBS 5 - WHOLE BODY TREMORS X 6 - CLONIC CONVULSIONS X 7 - WET DOG SHAKESCONVULSIONS - TONIC 1 - ABSENT XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2 - TONIC: CONTRACTION OF EXTENSORS SUCH THAT LIMBS ARE RIGID AND EXTENDED 3 - OPISTHOTONUS: HEAD, BODY AND LIMBS RIGIDLY ARCHED BACKWARDS 4 - EMPROSTHOTONUS: HEAD, BODY AND LIMBS EXTENDED FORWARD 5 - 'POPCORN SEIZURE': ANIMAL REPEATEDLY JUMPS OR BOUNCES IN AIR 6 - ASPHYXIAL: BOUTS OF SEVERE CLONIC-TONIC CONVULSIONS

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 WIL-99310 TABLE 1

FOB2 - INTER-OBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

Animal #52216 Animal #52247 Animal #52225 Animal #51868 Animal #52254 Animal #52338

TREMORS 1 - NONE XXXXXXXXXX XX XXXXXXXXXXXXXX X 2 - SLIGHT (1.5mm) XX X

 3 - MODERATELY COARSE (3 mm), SLIGHT IMPAIRMENT OF LOCOMOTION

 4 - MARKEDLY COARSE (4.5mm), MODERATE/MARKED IMPAIRMENT OF LOCOMOTION 5 - EXTREMELY COARSE (6 mm), LOCOMOTION IMPOSSIBLEGAIT SCORE 1 - NORMAL XXXXXXXXXXXXXXX XXXXX 2 - SLIGHT IMPAIRMENT, BUT DEFINITE XXX XX 3 - CONSIDERABLE IMPAIRMENT, WITHOUT FALLING X X XX X 4 - MARKED IMPAIRMENT, FALLS EVERY 4 TO 6 STEPS 5 - SEVERE IMPAIRMENT, CANNOT WALK WITHOUT FALLINGAROUSAL 1 - VERY LOW: STUPOR, COMA, LITTLE OR NO RESPONSIVENESS 2 - LOW: SOMEWHAT STUPOROUS X XX X X 3 - NORMAL: ALERT, EXPLORATORY MOVEMENTS XXXXXXXXXXXXXXXXXXXX X XX X X

 4 - SOMEWHAT HIGH: SLIGHT EXCITEMENT, TENSE, SUDDEN DARTING OR FREEZING 5 - VERY HIGH: HYPERALERT, EXCITED, SUDDEN BOUTS OF RUNNING OR BODY MOVEMENTSBIZARRE/STEREOTYPIC BEHAVIOR 1 - NONE XXXXXXXXXXXXXXX X XXX 2 - HEAD FLICK: HEAD SHAKING OR BACKWARD FLIP OF HEAD X XXXXXXX 3 - HEAD SEARCH: STEREOTYPED, REPETITIVE TURNING OF HEAD FROM SIDE TO SIDE XXXX XXXX 4 - HALLUCINATORY: APPEARS TO BE RESPONDING TO OBJECTS NOT PRESENT X 5 - COMPULSIVE LICKING OR BITING 6 - PRANCING: RESTLESS SHIFTING FROM ONE FORELIMB TO THE OTHER 7 - UPRIGHT WALKING: ON HINDLIMBS ONLY

 8 - AIMLESS WANDERING: PROGRESSIVE, SLOW, PLODDING MOVEMENTS, NO APPARENT PURPOSE

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 WIL-99310 TABLE 1

FOB2 - INTER-OBSERVER COMPARISONS

Observer: AEDCBAEDCBAEDCBAEDCBAEDCBAEDCB

Animal #52216 Animal #52247 Animal #52225 Animal #51868 Animal #52254 Animal #52338

BIZARRE/STEREOTYPIC BEHAVIOR (Continued) 9 - CIRCLING: TENDENCY TO MOVE IN CIRCLES AROUND OBJECTS, OR IN AN OPEN ENVIRONMENT XX XX X10 - WALTZING: RAPID TURNING IN CIRCLES11 - RETROPULSION: ANIMAL WALKS BACKWARDS XXXXXXX XX12 - SPATIAL DISORIENTATION: WALKING OR STUMBLING INTO OBJECTS13 - SIDE TO SIDE ROCKING14 - STRAUB TAIL: INCREASED TAIL ELEVATION15 - VERTICAL JUMPING16 - PACING WITHOUT PURPOSE17 - HEAD BOBBING XX XX

18 - WRITHING: LYING DOWN, WAVELIKE MOVEMENTS OF ABDOMEN, ALTERNATING LIMB MOVEMENTSPUPIL RESPONSE 1 - NO PUPIL RESPONSE X X X X XXXXXXXXX X

 2 - PUPIL RESPONSE PRESENT X XXXX XXXX X XX X XXXAIR RIGHTING REFLEX 1 - NORMAL XXXXXXXXXXXXXXX XXXX 2 - SLIGHTLY UNCOORDINATED X

 3 - LANDS ON SIDE XXX X 4 - LANDS ON BACK X XXX XX

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WIL-99310 PAGE 1

TABLE 2

FOB OBSERVATIONS – FINDINGS OMITTED

OBSERVER OBSERVATION NUMBER OMITTED

E MOBILITY 1

D MOBILITY 1

E CONVULSIONS- CLONIC 1

D FECES CONSISTENCY 1

A FECES CONSISTENCY 1

E BIZARRE/STEREOTYPIC BEHAVIOR 1

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Scoring Criteria for the Functional Observational Battery

Definition:

The Functional Observational Battery (FOB) is a procedure used to detect gross functional 

deficits in test animals. 

Description:

The FOB consists of a series of tests. The tests are categorized into home cage, handling, 

open field, sensory, neuromuscular and physiological observations and are as follows: 

1. Home Cage Observations

 a. Posture 

 b. Convulsions 

 c. Tremors 

 d. Biting 

 e. Palpebral (eyelid) closure 

 f. Feces Consistency 

2. Handling Observations

 a. Ease of removal from cage 

 b. Ease of handling animal in hand 

 c. Lacrimation 

 d. Chromodacryorrhea 

 e. Salivation 

 f. Piloerection 

 g. Fur appearance 

 h. Palpebral closure 

 i. Respiratory rate 

 j. Respiratory character 

 k. Red deposits 

 l. Crusty deposits 

 m. Mucous membranes/eye/skin color 

 n. Eye prominence 

 o. Muscle tone 

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3. Open Field Observations

 a. Time to first step (seconds) 

 b. Rearing 

 c. Mobility 

 d. Backing 

 e. Grooming 

 f. Gait 

 g. Convulsions 

 h. Tremors 

 i. Gait Score 

 j. Arousal 

 k. Bizarre/Stereotypic behavior 

 l. Urination 

 m. Defecation 

4. Sensory Observations

 a. Approach response 

 b. Touch response 

 c. Startle response 

 d. Tail pinch 

 e. Olfactory orientation 

 f. Pupil response 

 g. Eyeblink response 

 h. Forelimb extension 

 i. Hindlimb extension 

 j. Air righting reflex 

5. Neuromuscular Observations

 a. Hindlimb extensor strength 

 b. Grip strength-hind and forelimb 

 c. Rotarod performance 

 d. Hindlimb foot splay 

6. Physiological Observations

 a. Catalepsy 

 b. Body Temperature 

 c. Body Weight 

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Procedure

The FOB was performed on those study days specified in the study protocol. Test animals 

were removed from their "home cage" and placed into a separate bank in replicate order if 

the animals are not normally housed in replicate order with blinded cage cards. Test animals 

were allowed a minimum of 15 minutes in this new caging prior to the start of the FOB. 

Test animals were removed from this caging one at a time on the designated day of testing, 

and unless specified by study protocol were taken through the FOB in the following order: 

FOB1 (inclusive of categories 1a-1f and 2a), FOB2 (inclusive of categories 2b-2o, 3a-3m 

and 4a-4J) and FOB3 (inclusive of categories 5a-5d and 6a-6c). 

Testing was performed by technicians, who did not know the group assignment of the 

animals. A description of the scoring criteria for each test is provided below: 

1. HOME CAGE OBSERVATIONS

 Observations of the animal in its home cage and while opening the home cage were 

performed and scored as follows: 

 a. Posture

 Sitting or standing normally 1 

 Asleep, lying on side or curled up 2 

 Alert, oriented toward observer 3 

 Sitting, head held low 4 

 Flattened, limbs may be extended 5 

 Lying on side, limbs in air 6 

 Immobile 7 

 Rearing 8 

 b. Convulsions

 I. Clonic

 Absent 1 

 Repetitive movement of mouth and jaws 2 

 Clonic tremors of the limbs 

 (contraction followed by relaxation) 3 

 Whole body tremors 4 

 Clonic convulsions 5 

 Wet Dog Shakes 6 

 'Popcorn seizure': animal repeatedly jumps or 

 bounces in air 7 

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 II. Tonic

 Absent 1 

 Tonic: contraction of extensors such that 

 limbs are rigid and extended 2 

 Opisthotonus: head, body and limbs rigidly 

 arched backwards 3 

 Emprosthotonus: head, body and limbs 

 extended forward 4 

 Asphyxial: bouts of severe clonic-tonic 

 convulsions 5 

 c. Tremors

 None 1 

 Slight (1.5 mm) 2 

 Moderately coarse (3 mm), slight impairment 

 of locomotion 3 

 Markedly coarse (4.5 mm), moderate/marked 

 impairment of locomotion 4 

 Extremely coarse (6 mm), locomotion impossible 5 

 d. Biting

 None 1 

 Biting of cage 2 

 Biting of self 3 

 e. Palpebral (eyelid) closure

 Eyelids wide open 1 

 Eyelids slightly drooping 2 

 Drooping eyelids (half closed) 3 

 Eyelids completely shut 4 

 f. Feces Consistency 

 Pellets 1 

 Pellets, partially formed 2 

 Unformed, diarrhea 3 

 Pellets absent 4 

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2. HANDLING OBSERVATIONS

 Animals were removed singly from their cages and observed and scored as follows: 

 a. Ease of removal from cage

 Very easy: animal sits quietly, allows investigator 

 to pick it up 1 

 Easy: with or without vocalization, without 

 resistance or slight resistance to being picked up 2 

 Moderately difficult: animal rears, often following 

 investigator’s hand 3 

 Freezes: with or without vocalization 4 

 Difficult: runs around cage, is hard to grab, 

 with or without vocalization 5 

 Very difficult: tail and throat rattles with or 

 without vocalization, may attack hand 6 

 b. Ease of handling animal in hand

 No resistance, animal is easy to handle 1 

 Slight resistance to being handled, 

 with or without vocalization 2 

 May freeze, or be tense or rigid in hand, 

 with or without vocalization 3 

 Twists, attempts to bite 

 with or without vocalization 4 

 c. Lacrimation

 None 1 

 Slight 2 

 Severe 3 

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 d. Chromodacryorrhea 

 

 Absent 1 

 Present 2 

 e. Salivation

 None 1 

 Slight 2 

 Severe 3 

 f. Piloerection

 None 1 

 Slight 2 

 Severe 3 

 g. Fur Appearance

 Normal: clean and groomed 1 

 Slightly soiled 2 

 Very soiled, crusty 3 

 h. Palpebral closure

 Eyelids wide open 1 

 Eyelids slightly drooping 2 

 Drooping eyelids (half closed) 3 

 Eyelids completely shut 4 

 i. Respiratory Rate

 Normal: by observation (80-110/min.) 1 

 Decreased: below 80/min. 2 

 Increased: above 110/min. 3 

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 j. Respiratory Character

 Normal 1 

 Rales: abnormal sound accompanying breathing 2 

 Retching 3 

 Dyspneic: short of breath 4 

 Gasping 5 

 k. Red Deposits - eyes, nose, mouth 

 Present 1 

 Absent 2 

 l. Crusty Deposits - eyes, nose, mouth 

 Present 1 

 Absent 2 

 m. Mucous membranes/eye/skin color

 Pink 1 

 Pale 2 

 Darkened 3 

 Darkened, brown 4 

 Bright, deep red flush 5 

 n. Eye Prominence

 Normal 1 

 Exophthalmus 2 

 Enophthalmus 3 

 o. Muscle Tone

 The musculature of the limbs was palpated between the thumb and forefinger. 

 Muscle is firm but not hard (normal) 1 

 Muscle is soft and flabby 2 

 Muscle is tense and hard 3 

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3. OPEN FIELD OBSERVATIONS

 Animals were placed singly in the open field arena (24" x 24" x 6"; constructed from 

Plexiglas® and painted black) and evaluated over a 2-minute observation period as 

follows: 

 a. Time to first step (seconds)

 The time taken for the animal to take its first step in the open field arena was 

recorded to the hundredth (0.01) of a second. 

 b. Rearing

 The number of times the animal reared back onto its hind legs and stood up with 

both front paws raised off the surface was recorded over a 2-minute observation 

period in the open field arena. 

 c. Mobility (scored within 30 seconds of placing animal in the open field arena) 

 Normal 1 

 Slightly Impaired 2 

 Moderately Impaired 3 

 Totally Impaired, Locomotion impossible 4 

 d. Backing

 The number of times the animal took three or more backward steps over a 

2-minute observation period in the open field arena was recorded. 

 e. Grooming

 The number of times the animal groomed itself over a 2-minute observation 

period in the open field arena was recorded. Grooming included washing the 

face and head with the forepaws, scratching the head or body with a hind paw, 

and biting the fur. 

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 f. Gait

 Normal, head horizontal, abdomen just above surface, 

 slight up and down movement with each step 1 

 Walks on tiptoes 2 

 Body drags, abdomen makes contact with surface, body sway 3 

 Hindlimbs splayed or dragging, unable to support weight 4 

 Hunched body, bottom up, nose held down, arched back 5 

 Ataxia, excessive sway, rocks or lurches as animal proceeds 

 forward 6 

 Walks on Metatarsus 7 

 g. Convulsions

 I. Clonic

 Absent 1 

 Repetitive movement of mouth and jaws 2 

 Clonic tremors of the limbs 

 (contraction followed by relaxation) 3 

 Whole body tremors 4 

 Clonic convulsions 5 

 Wet Dog Shakes 6 

 'Popcorn seizure': animal repeatedly jumps or bounces 

 in air 7 

 II. Tonic

 Absent 1 

 Tonic: contraction of extensors such that limbs 

 are rigid and extended 2 

 Opisthotonus: head, body and limbs rigidly arched 

 backwards 3

 Emprosthotonus: head, body and limbs arched forward 4 

 Asphyxial: bouts of severe clonic-tonic convulsions 5 

 h. Tremors

 None 1 

 Slight (1.5 mm) 2 

 Moderately coarse (3 mm), slight impairment of locomotion 3 

 Markedly coarse (4.5 mm), moderate/marked impairment 

 of locomotion 4 

 Extremely coarse (6 mm), locomotion impossible 5 

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 i. Gait Score: Ability to locomote despite abnormalities in gait 

 Normal 1 

 Slight impairment, but definite 2 

 Considerable impairment, without falling 3 

 Marked impairment, falls every 4 to 6 steps 4 

 Severe impairment, cannot walk without falling 5 

 j. Arousal

 Very low: Stupor, coma, little or no responsiveness 1 

 Low: Somewhat stuporous 2 

 Normal: Alert, exploratory movements 3 

 Somewhat high: Slight excitement, tense, excited sudden 

 darting or freezing 4 

 Very high: Hyperalert, excited, sudden bouts of running 

 or body movements 5 

 k. Bizarre/Stereotypic Behavior 

 None 1 

 Head Flick: head shaking or backward flip of head 2 

 Head Search: stereotyped, repetitive turning of head 

 from side to side as though searching the environment 3 

 Hallucinatory: animal appears to be responding to objects 

 not present 4 

 Compulsive licking or biting 5 

 Prancing: restless shifting from one forelimb to other, 

 with slight turning of the body from side to side 6 

 Upright walking: on hindlimbs only 7 

 Aimless wandering: progressive, slow, plodding movements 

 about environment, with no apparent purpose 8 

 Circling: tendency to move in circles around and along 

 objects, or in an open environment 9 

 Waltzing: rapid turning in circles 10 

 Retropulsion: where animal walks backwards 11 

 Spatial disorientation: walking or stumbling into objects 12 

 Side to side rocking 13 

 Straub tail: increased tail elevation 14 

 Vertical Jumping 15 

 Pacing without purpose 16 

 Head bobbing 17 

 Writhing: lying down, wavelike movement of abdomen, 

 alternating limb movements 18 

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 l. Urination

 The number of pools of urine in the open field arena was counted. 

 m. Defecation

 The number of fecal boli in the open field arena was counted. 

4. SENSORY OBSERVATIONS

 Sensory tests were performed in the open field arena as follows: 

 a. Approach Response

 The animal was approached head-on with a blunt object held approximately 

3 cm from its face for a 4-second period. 

 No reaction 1 

 Slow approach, sniffing or turning away 2 

 More energetic than (2) may include vocalization 3 

 Freezes, actual muscle contraction 4 

 Bizarre reaction: jumps, bites or attacks 5 

 b. Touch Response

 The rump of the animal was approached from the side and touched with a blunt 

object.

 No reaction 1 

 Animal may slowly turn, walk away 2 

 More energetic response than (2), may include vocalization 3 

 Freezes, actual muscle contraction 4 

 Bizarre reaction: jumps, bites or attacks 5 

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 c. Startle Response

 A clicker held approximately 5 cm above the head of the animal was used to 

make a sudden sound. 

 No reaction 1 

 Slight reaction, ear flick or some evidence that snap 

 was heard 2 

 More energetic response than (2), may include vocalization 3 

 Freezes, actual muscle contraction 4 

 Bizarre reactions: jumps, attacks, bites 5 

 d. Tail Pinch

 Metal tweezers were used to squeeze tail approximately 2-3 cm from tip. 

 No reaction 1 

 Animal may turn or walk away 2 

 More energetic than (2), may include vocalization 3 

 Freezes, actual muscle contraction 4 

 Bizarre reaction: jumps, attacks or bites 5 

 e. Olfactory Orientation

 Approaching the animal from behind, a cotton swab that had been dipped into a 

jar of commercially available homogenized baby food was brought to within 

approximately 4-5 cm of the side of the animal's head. 

 No reaction present 1 

 Reaction present, animal approaches swab making sniffing 

 movements with nose, may lick swab 2 

 f. Pupil Response

 The beam from a pen light was brought to within approximately 5 mm of the 

surface of the eye. Changes in pupil size were recorded. 

 No pupil response 1 

 Pupil response present 2 

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 g. Eyeblink Response

 The corner of the eye was touched gently with a blunt object. 

 No eyeblink response 1 

 Eyeblink response present 2 

 h. Forelimb Extension

 The animal was held by the tail and lowered towards a table top. The presence 

or absence of normal forelimb extension was recorded. 

 No forelimb extension 1 

 Forelimb extension present 2 

 i. Hindlimb Extension

 The animal was placed on a table top and lifted by the tail. The presence of 

normal hindlimb extension was recorded. 

 No hindlimb extension 1 

 Hindlimb extension present 2 

 j. Air Righting Reflex

 The animal was held in a supine position and dropped from a height of 

approximately 30 cm. The ease of landing was scored as follows: 

 Normal 1 

 Slightly uncoordinated 2 

 Lands on side 3 

 Lands on back 4 

5. NEUROMUSCULAR OBSERVATIONS

 a. Hindlimb Extensor Strength

 The animal was picked up and slight pressure was applied to its hindlimbs. The 

normal response is for the animal to extend its hindlimbs against the pressure. 

 Hindlimb resistance absent 1 

 Reduced hindlimb resistance, animal shows some weakness 2 

 Hindlimb resistance present 3 

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 b. Grip Strength - hind and forelimb

 

 Forelimb and hindlimb grip strength were measured using a device similar to the 

one described by Meyer et al (Neurobehav. Toxicol. 1:233-239, 1979). The 

animal was allowed to grip a T-shaped grip bar with its forepaws and was pulled 

back gently along a platform until its grip was broken. As the backward 

locomotion continued, the animal's hindpaws reached a T-shaped rearlimb grip 

bar, which it was allowed to grasp and then forced to release by continued 

pulling. Mark-10 series EG digital force gauge (Mark-10 Corporation, 

Copiague, NY) was used to record the maximum strain required to break 

forelimb and hindlimb grip. The average of three valid measurements was taken 

as the animal's score for each grip strength measure. Grip strength 

measurements were recorded as grams (g). 

 c. Rotarod Performance

 During the pretest period, the animals were trained to walk on a rotarod (a 

7.0-cm-diameter rod rotating at 12 rpm; AccuScan Instruments, Inc., Columbus, 

Ohio) for a period of two minutes. The duration of time each animal remained 

on the rotarod (up to a maximum time of 120 seconds) during testing was 

recorded.

 d. Hindlimb Foot Splay

 The heel pads of the hindfeet of the animal were painted with a non-toxic 

water-based paint. Animals are dropped from a horizontal position 

approximately 30 cm above a table onto the Hindlimb Foot Splay Test sheet. 

The distance (to the nearest millimeter) between the inner edge of the ink blots 

made by each foot was measured. The test was repeated two more times; and 

the average score (to the nearest millimeter) of the latter two trials was 

calculated.

6. PHYSIOLOGICAL OBSERVATIONS

 a. Catalepsy

 The animal was placed on four Plexiglas® platforms (35 mm high and 40 mm in 

diameter) that were a distance of 100 mm from each other between the fore and 

hind feet and 60 mm between right and left feet (when measured from the center 

of the platforms). The time each animal remained on the four platforms was 

recorded. The duration of immobility was measured (up to a maximum time of 

60 seconds). 

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 b. Body Temperature

 A thermometer was inserted into the rectum of the animal, and the body 

temperature was recorded after an equilibration period of approximately 

30 seconds. Temperatures were recorded to the tenth (0.1) of a degree. 

 c. Body Weight

 The weight of the animal was recorded. 

The Functional Observational Battery is normally recorded on-line via the 

"IFOB" program in NT-module. In the event that the Data Management System 

is unavailable for on-line data collection, data are hand-recorded on the 

Functional Observational Battery Individual Data Sheets (T1-228, as revised). 

When appropriate, the hand-recorded data are late entered into the Data 

Management System. 

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BioSTAT Consultants, Inc. 

Statement of Quality Control 

This report was quality checked in accordance with BioSTAT Procedural Guideline 2.2 

(Quality Control Process for Tables and Reports). The statistical methodology and 

results of inferential statistics were verified by an independent quality control statistician.

Based on these documented quality control activities, it is concluded that the statistical 

results incorporated in this report accurately reflect the statistical analysis of data 

received by BioSTAT. 

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1 Statistical Methodology 

1.1 Analysis Endpoints 

x Motor Activity 

o Total Count 

o Ambulatory Count 

1.2 Motor Activity Analysis Methodology 

Each analysis endpoint was analyzed, by sex and session, with a repeated measure 

analysis of variance (RMANOVA). Factors in the model included treatment group (TRT), 

time interval (TIME), and the interaction of time interval and treatment group 

(TRT*TIME). The SAS® procedure PROC MIXED was used for analysis with the 

random effect of animal included as the repeated measurement. The covariance structure 

across time was selected by comparing Akaike’s Information Criterion (AIC). 

The monotonic dose response relationship was evaluated using sequential linear trend 

tests based on ordinal spacing of dose levels. The linear dose by time interaction 

(LinTrt*Time) was evaluated and, if significant at the 0.05 level, trend tests on treatment 

means were performed at the 0.05 level for each time interval. If the linear dose by time 

interaction was not significant, the trend test was conducted across the pooled time 

intervals of the entire session only. 

Nonmonotonic dose responses were evaluated whenever no significant linear trends were 

detected but TRT and/or TRT*TIME interaction was significant at the 0.01 level. Within 

the framework of the RMANOVA, pairwise comparisons were made for each individual 

treated group with the control group through linear contrasts. If TRT* TIME was 

significant, the comparisons were conducted for each time interval. If only the TRT 

effect was significant, the comparisons were conducted across the pooled time intervals 

of the entire session. These nonmonotonic dose response comparisons were conducted at 

the 0.01 significance level. 

All statistical analyses were conducted using SAS® software.

2 Results

Results of statistical analyses are summarized in Section 3 and statistically significant 

dose group findings are shown in Table 2.1.

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Table 2.1: Summary of Statistically Significant Dose Group Findings 

Motor Activity

Minutes

Period Sex Endpoint 0-10 11-20 21-30 31-40 41-50 51-60 Overall 

PRETEST M Total NS

 Ambulatory Ļ2Ļ3 NS NS NS NS NS NS 

 F Total NS 

 Ambulatory NS 

WEEK_003 M Total NS

 Ambulatory NS 

 F Total NS 

 Ambulatory NS 

A blank cell implies individual time point was not analyzed per statistical methodology 

NS: Not statistically significant 

Ĺ (Ļ) Dose-related increase (decrease) through 2500 ppm dose group 

ĹĹ (ĻĻ) Dose-related increase (decrease) through 2000 ppm dose group 

ĹĹĹ (ĻĻĻ) Dose-related increase (decrease) through 1500 ppm dose group 

ĹĹĹĹ (ĻĻĻĻ) Dose-related increase (decrease) through 1000 ppm dose group 

Ĺ2 (Ļ2) Increase (decrease) at 2000 ppm dose group relative to control 

Ĺ3 (Ļ3) Increase (decrease) at 1500 ppm dose group relative to control 

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Tables Legend 

Motor Activity: For each analysis endpoint (study period/sex/endpoint), data are 

summarized by treatment group for each post-dose time interval, overall (mean across 

post-dose time intervals), and cumulative across post-dose time intervals. P-values for 

interaction terms are shown at the bottom of the table. If LinTrt*Time was not 

significant, sequential trend testing (described below) was conducted across the pooled 

time intervals only and the p-values are reported in the “Overall” row. “NT” (not tested) 

is reported for the p-value in the individual time interval rows. If LinTrt*Time was 

significant, sequential trend testing was conducted for each individual time interval as 

well as across the pooled time intervals. P-values are reported in the individual time 

interval and “Overall” rows. 

Sequential trend tests: All dose groups are included in an initial trend test. If the trend 

test is not significant it is concluded that there is no significant dose-related trend and no 

further testing is conducted. If the trend test is significant, the highest dose group is 

flagged as significant and a trend test is conducted excluding the highest dose group. The 

sequence of trend tests continues until a test is not significant or the lowest nonzero dose 

is flagged as significant. 

Table Key 

S.D. = standard deviation of the sample 

S.E. = standard error (standard deviation of the mean) 

N = number of animals 

% Difference Control = group mean percent difference from control 

Linear Trend p-value = p-value for the treatment linear trend test 

Trt F-test p-value = p-value for treatment group effect 

Trt*Time p-value = p-value for the treatment by time interaction 

LinTrt*Time p-value = p-value for the linear trend by time interaction 

Covariance Structure: AR1=Autoregressive order 1, CS=Compound symmetric, 

ARH(1)=Autoregressive heterogenous order 1, CSH=Compound symmetric 

heterogenous

References 

SAS® Proprietary Software; SAS Institute Inc.: Cary, NC, 2002-2003. 

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3 Statistical Analysis Summaries Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ PRETEST M TOTAL 0-10 Mean 1330 1121 1117 1070 1348 % Difference Control NA -15.7 -16.0 -19.5 1.4 S.D. 117.2 227.4 201.5 288.3 251.5 S.E. 37.0 71.9 63.7 91.2 79.5 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 11-20 Mean 841 729 696 620 817 % Difference Control NA -13.3 -17.2 -26.3 -2.9 S.D. 268.5 340.1 236.0 283.5 427.2 S.E. 84.9 107.6 74.6 89.6 135.1 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 21-30 Mean 545 561 373 408 689 % Difference Control NA 2.9 -31.6 -25.1 26.4 S.D. 333.4 283.0 308.7 253.9 270.2 S.E. 105.4 89.5 97.6 80.3 85.5 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 31-40 Mean 309 357 215 522 450 S.D. 270.4 346.9 243.6 395.1 389.8 S.E. 85.5 109.7 77.0 124.9 123.3 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ PRETEST M TOTAL 41-50 Mean 132 243 211 294 182 S.D. 112.2 288.5 236.6 304.8 277.8 S.E. 35.5 91.2 74.8 96.4 87.8 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 51-60 Mean 81 144 194 185 128 S.D. 44.7 193.0 320.8 303.6 118.7 S.E. 14.1 61.0 101.5 96.0 37.5 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT Cumulative Mean 3237 3154 2806 3100 3615 % Difference Control NA -2.6 -13.3 -4.2 11.7 S.D. 894.8 1158.3 1009.0 1261.2 1505.9 S.E. 283.0 366.3 319.1 398.8 476.2 N 10 10 10 10 10 Overall Linear Trend p-value# NT NT NT 0.538 Trt F-test p-value++ 0.624 Trt*Time p-value++ 0.062 LinTrt*Time p-value# 0.677 Covariance Structure ARH1---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ PRETEST M AMBULATORY 0-10 Mean 425 336 294 289 469 % Difference Control NA -20.9 -30.8 -32.0 10.4 S.D. 78.1 85.8 91.5 91.4 134.2 S.E. 24.7 27.1 28.9 28.9 42.4 N 10 10 10 10 10 Pairwise p-value++ 0.045 0.003* 0.002* 0.322 Linear Trend p-value# NT NT NT NT 11-20 Mean 193 195 154 135 200 % Difference Control NA 1.0 -20.2 -30.1 3.6 S.D. 103.7 137.2 61.9 70.6 144.5 S.E. 32.8 43.4 19.6 22.3 45.7 N 10 10 10 10 10 Pairwise p-value++ 0.969 0.403 0.214 0.896 Linear Trend p-value# NT NT NT NT 21-30 Mean 121 124 81 73 146 % Difference Control NA 2.5 -33.1 -39.7 20.7 S.D. 108.0 85.9 76.3 63.6 121.1 S.E. 34.2 27.2 24.1 20.1 38.3 N 10 10 10 10 10 Pairwise p-value++ 0.939 0.329 0.242 0.531 Linear Trend p-value# NT NT NT NT 31-40 Mean 72 66 26 111 70 S.D. 78.1 86.6 46.0 134.4 140.0 S.E. 24.7 27.4 14.5 42.5 44.3 N 10 10 10 10 10 Pairwise p-value++ 0.888 0.316 0.395 0.970 Linear Trend p-value# NT NT NT NT---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ PRETEST M AMBULATORY 41-50 Mean 17 46 27 42 41 S.D. 38.4 99.9 46.9 67.8 85.5 S.E. 12.1 31.6 14.8 21.4 27.0 N 10 10 10 10 10 Pairwise p-value++ 0.357 0.753 0.430 0.432 Linear Trend p-value# NT NT NT NT 51-60 Mean 1 25 36 27 10 S.D. 1.1 56.3 75.9 63.3 24.6 S.E. 0.3 17.8 24.0 20.0 7.8 N 10 10 10 10 10 Pairwise p-value++ 0.353 0.179 0.313 0.726 Linear Trend p-value# NT NT NT NT Cumulative Mean 829 792 619 677 937 % Difference Control NA -4.5 -25.3 -18.3 13.0 S.D. 332.5 387.9 263.3 291.1 561.9 S.E. 105.2 122.7 83.2 92.1 177.7 N 10 10 10 10 10 Overall Pairwise p-value++ 0.823 0.208 0.361 0.516 Linear Trend p-value# NT NT NT 0.786 Trt F-test p-value++ 0.338 Trt*Time p-value++ <0.001* LinTrt*Time p-value# 0.954 Covariance Structure CSH---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ PRETEST F TOTAL 0-10 Mean 1530 1336 1477 1276 1453 % Difference Control NA -12.7 -3.5 -16.6 -5.0 S.D. 366.1 364.4 186.1 249.0 308.1 S.E. 115.8 115.2 58.8 78.7 97.4 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 11-20 Mean 732 753 695 742 848 % Difference Control NA 2.9 -5.1 1.4 15.8 S.D. 430.6 254.7 307.9 455.2 386.4 S.E. 136.2 80.5 97.4 144.0 122.2 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 21-30 Mean 554 456 518 433 438 % Difference Control NA -17.7 -6.5 -21.8 -20.9 S.D. 404.5 378.9 416.7 328.8 340.1 S.E. 127.9 119.8 131.8 104.0 107.6 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 31-40 Mean 596 335 577 285 332 S.D. 499.8 321.6 441.7 327.9 329.4 S.E. 158.1 101.7 139.7 103.7 104.2 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ PRETEST F TOTAL 41-50 Mean 364 344 360 237 210 S.D. 339.1 367.3 374.5 222.3 251.2 S.E. 107.2 116.2 118.4 70.3 79.4 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 51-60 Mean 413 471 489 398 290 S.D. 387.0 355.5 472.8 510.8 327.3 S.E. 122.4 112.4 149.5 161.5 103.5 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT Cumulative Mean 4187 3694 4116 3370 3570 % Difference Control NA -11.8 -1.7 -19.5 -14.7 S.D. 1451.6 907.8 1431.0 1007.8 536.9 S.E. 459.0 287.1 452.5 318.7 169.8 N 10 10 10 10 10 Overall Linear Trend p-value# NT NT NT 0.176 Trt F-test p-value++ 0.438 Trt*Time p-value++ 0.962 LinTrt*Time p-value# 0.724 Covariance Structure AR1---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ PRETEST F AMBULATORY 0-10 Mean 520 449 509 422 473 % Difference Control NA -13.7 -2.1 -18.8 -9.0 S.D. 154.6 149.5 110.9 101.4 128.8 S.E. 48.9 47.3 35.1 32.1 40.7 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 11-20 Mean 190 186 185 199 232 % Difference Control NA -2.1 -2.6 4.7 22.1 S.D. 156.5 74.0 94.3 182.0 144.3 S.E. 49.5 23.4 29.8 57.6 45.6 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 21-30 Mean 155 112 165 90 88 % Difference Control NA -27.7 6.5 -41.9 -43.2 S.D. 124.9 108.8 160.5 91.6 96.7 S.E. 39.5 34.4 50.7 29.0 30.6 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 31-40 Mean 176 65 161 72 70 S.D. 174.0 71.2 173.6 115.8 85.0 S.E. 55.0 22.5 54.9 36.6 26.9 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ PRETEST F AMBULATORY 41-50 Mean 97 82 93 47 30 S.D. 118.1 105.8 128.9 66.6 62.1 S.E. 37.4 33.5 40.8 21.0 19.6 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 51-60 Mean 104 123 151 105 57 S.D. 149.0 105.1 155.1 174.0 88.1 S.E. 47.1 33.2 49.1 55.0 27.9 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT Cumulative Mean 1243 1017 1263 933 952 % Difference Control NA -18.2 1.6 -24.9 -23.4 S.D. 572.4 327.0 551.4 361.6 200.7 S.E. 181.0 103.4 174.4 114.4 63.5 N 10 10 10 10 10 Overall Linear Trend p-value# NT NT NT 0.126 Trt F-test p-value++ 0.249 Trt*Time p-value++ 0.865 LinTrt*Time p-value# 0.470 Covariance Structure AR1---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ WEEK_003 M TOTAL 0-10 Mean 1304 1211 1177 1107 1355 % Difference Control NA -7.1 -9.7 -15.1 3.9 S.D. 195.1 212.6 352.7 375.3 382.2 S.E. 61.7 67.2 111.5 125.1 120.9 N 10 10 10 9 10 Linear Trend p-value# NT NT NT NT 11-20 Mean 694 575 579 522 661 % Difference Control NA -17.1 -16.6 -24.8 -4.8 S.D. 256.2 299.6 285.3 167.4 219.1 S.E. 81.0 94.8 90.2 55.8 69.3 N 10 10 10 9 10 Linear Trend p-value# NT NT NT NT 21-30 Mean 441 413 369 291 464 % Difference Control NA -6.3 -16.3 -34.0 5.2 S.D. 252.0 265.0 214.3 162.4 247.5 S.E. 79.7 83.8 67.8 54.1 78.3 N 10 10 10 9 10 Linear Trend p-value# NT NT NT NT 31-40 Mean 438 338 311 355 431 S.D. 277.6 292.5 305.5 217.6 251.3 S.E. 87.8 92.5 96.6 72.5 79.5 N 10 10 10 9 10 Linear Trend p-value# NT NT NT NT---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ WEEK_003 M TOTAL 41-50 Mean 334 201 153 224 337 S.D. 186.5 206.5 173.6 229.7 301.0 S.E. 59.0 65.3 54.9 76.6 95.2 N 10 10 10 9 10 Linear Trend p-value# NT NT NT NT 51-60 Mean 125 134 355 113 158 S.D. 203.8 261.5 323.8 245.6 227.0 S.E. 64.4 82.7 102.4 81.9 71.8 N 10 10 10 9 10 Linear Trend p-value# NT NT NT NT Cumulative Mean 3335 2872 2943 2613 3406 % Difference Control NA -13.9 -11.8 -21.6 2.1 S.D. 605.7 1032.1 990.3 769.0 991.4 S.E. 191.5 326.4 313.1 256.3 313.5 N 10 10 10 9 10 Overall Linear Trend p-value# NT NT NT 0.898 Trt F-test p-value++ 0.269 Trt*Time p-value++ 0.687 LinTrt*Time p-value# 0.998 Covariance Structure AR1---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ WEEK_003 M AMBULATORY 0-10 Mean 309 292 269 250 370 % Difference Control NA -5.5 -12.9 -19.1 19.7 S.D. 74.9 96.7 144.9 98.1 136.7 S.E. 23.7 30.6 45.8 32.7 43.2 N 10 10 10 9 10 Linear Trend p-value# NT NT NT NT 11-20 Mean 129 112 99 82 115 % Difference Control NA -13.2 -23.3 -36.4 -10.9 S.D. 69.3 82.0 71.6 25.8 62.1 S.E. 21.9 25.9 22.6 8.6 19.6 N 10 10 10 9 10 Linear Trend p-value# NT NT NT NT 21-30 Mean 84 86 50 35 87 % Difference Control NA 2.4 -40.5 -58.3 3.6 S.D. 64.1 67.2 36.0 29.5 72.0 S.E. 20.3 21.3 11.4 9.8 22.8 N 10 10 10 9 10 Linear Trend p-value# NT NT NT NT 31-40 Mean 94 64 62 53 74 S.D. 72.9 73.4 77.2 42.5 69.8 S.E. 23.1 23.2 24.4 14.2 22.1 N 10 10 10 9 10 Linear Trend p-value# NT NT NT NT---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ WEEK_003 M AMBULATORY 41-50 Mean 54 40 18 34 67 S.D. 51.4 47.2 28.5 42.2 92.1 S.E. 16.3 14.9 9.0 14.1 29.1 N 10 10 10 9 10 Linear Trend p-value# NT NT NT NT 51-60 Mean 16 23 61 26 24 S.D. 33.3 62.7 55.5 75.4 42.8 S.E. 10.5 19.8 17.5 25.1 13.5 N 10 10 10 9 10 Linear Trend p-value# NT NT NT NT Cumulative Mean 685 616 560 480 736 % Difference Control NA -10.1 -18.2 -29.9 7.4 S.D. 159.8 306.6 294.6 150.8 302.7 S.E. 50.5 97.0 93.2 50.3 95.7 N 10 10 10 9 10 Overall Linear Trend p-value# NT NT NT 0.891 Trt F-test p-value++ 0.158 Trt*Time p-value++ 0.419 LinTrt*Time p-value# 0.699 Covariance Structure ARH1---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ WEEK_003 F TOTAL 0-10 Mean 1347 1432 1412 1356 1351 % Difference Control NA 6.3 4.8 0.7 0.3 S.D. 225.2 319.9 259.8 319.7 344.5 S.E. 71.2 101.2 82.2 101.1 108.9 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 11-20 Mean 585 800 807 740 461 % Difference Control NA 36.8 37.9 26.5 -21.2 S.D. 324.1 409.1 337.4 316.2 197.7 S.E. 102.5 129.4 106.7 100.0 62.5 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 21-30 Mean 438 553 603 300 547 % Difference Control NA 26.3 37.7 -31.5 24.9 S.D. 393.5 327.3 359.1 282.4 262.9 S.E. 124.4 103.5 113.5 89.3 83.1 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 31-40 Mean 388 443 499 292 281 S.D. 314.0 328.3 479.1 263.9 245.8 S.E. 99.3 103.8 151.5 83.5 77.7 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ WEEK_003 F TOTAL 41-50 Mean 366 452 403 206 201 S.D. 354.0 343.1 409.2 227.6 206.0 S.E. 112.0 108.5 129.4 72.0 65.1 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 51-60 Mean 362 221 465 250 424 S.D. 325.0 358.6 587.7 237.8 421.1 S.E. 102.8 113.4 185.9 75.2 133.2 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT Cumulative Mean 3486 3900 4189 3145 3264 % Difference Control NA 11.9 20.2 -9.8 -6.4 S.D. 1446.8 1173.8 2105.9 975.1 924.1 S.E. 457.5 371.2 665.9 308.3 292.2 N 10 10 10 10 10 Overall Linear Trend p-value# NT NT NT 0.394 Trt F-test p-value++ 0.422 Trt*Time p-value++ 0.132 LinTrt*Time p-value# 0.291 Covariance Structure AR1---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ WEEK_003 F AMBULATORY 0-10 Mean 399 422 395 395 369 % Difference Control NA 5.8 -1.0 -1.0 -7.5 S.D. 106.6 148.1 116.4 135.6 125.1 S.E. 33.7 46.8 36.8 42.9 39.6 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 11-20 Mean 142 194 212 167 78 % Difference Control NA 36.6 49.3 17.6 -45.1 S.D. 90.3 140.8 127.3 106.3 46.9 S.E. 28.6 44.5 40.3 33.6 14.8 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 21-30 Mean 114 127 157 69 109 % Difference Control NA 11.4 37.7 -39.5 -4.4 S.D. 140.4 94.6 126.1 115.8 80.6 S.E. 44.4 29.9 39.9 36.6 25.5 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 31-40 Mean 102 107 121 73 40 S.D. 111.1 83.7 165.1 92.7 44.6 S.E. 35.1 26.5 52.2 29.3 14.1 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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Table 3.1: Analysis Summary Table for Motor Activity  Target Exposure Level (ppm) ______________________________________________________ Statistical 0 1000 1500 2000 2500 Model Period Sex Variable Minutes Statistic __________ __________ __________ __________ __________ ____________ WEEK_003 F AMBULATORY 41-50 Mean 87 118 106 52 30 S.D. 113.7 97.5 160.1 75.1 54.2 S.E. 36.0 30.8 50.6 23.8 17.1 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT 51-60 Mean 95 60 136 49 108 S.D. 98.1 119.1 228.3 59.3 129.1 S.E. 31.0 37.7 72.2 18.8 40.8 N 10 10 10 10 10 Linear Trend p-value# NT NT NT NT Cumulative Mean 938 1029 1127 805 734 % Difference Control NA 9.7 20.1 -14.2 -21.7 S.D. 499.9 461.5 828.1 381.7 268.0 S.E. 158.1 145.9 261.9 120.7 84.8 N 10 10 10 10 10 Overall Linear Trend p-value# NT NT NT 0.242 Trt F-test p-value++ 0.477 Trt*Time p-value++ 0.223 LinTrt*Time p-value# 0.430 Covariance Structure AR1---------------------------------------------------------------------------------------------------------------------# : Level of Significance tested = .05. ++ : Level of Significance tested = .01. * : Statistically Significant. NT : Not tested. NA : Not applicable. 

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" # $ % !&!' ()

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HC # ROUTE VEHICLE START END

AGE AT START IN 

WEEKS

1 ORAL DIET 11/16/00 02/16/01 72 ORAL SESAME OIL 10/25/00 01/25/01 73 ORAL PEG 400 07/30/99 09/10/99 64 ORAL DISTILLED WATER 06/18/99 06/16/99 65 ORAL DISTILLED WATER 11/09/99 12/21/99 86 ORAL 0.5% MC / 0.2% TWEEN 80 08/28/00 09/26/00 77 ORAL DEIONIZED WATER 01/25/01 02/22/01 78 ORAL DEIONIZED WATER 11/05/01 12/03/01 79 ORAL OLIVE OIL 11/21/01 12/19/01 7

10 ORAL CORN OIL 04/26/00 08/23/00 711 ORAL CORN OIL 06/14/99 07/26/99 612 ORAL CORN OIL 06/21/99 08/02/99 613 ORAL DIET 06/21/99 10/18/99 714 ORAL DIET 01/22/01 04/26/01 615 ORAL DEIONIZED WATER 02/27/01 05/31/01 616 ORAL DEIONIZED WATER 05/10/05 08/10/05 717 ORAL CORN OIL 02/13/06 03/27/05 818 ORAL CORN OIL 03/22/06 05/03/06 819 ORAL CORN OIL 01/06/05 02/07/05 720 ORAL OLIVE OIL 01/03/06 02/14/06 721 ORAL DEIONIZED WATER 12/12/05 06/13/06 622 ORAL DEIONIZED WATER 05/06/05 06/03/05 7

Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control

Study Table

Crl:CD(SD) Rats Page 1 of 66

Crl:CD(SD) Rat Subchronic FOB HC v.1.1

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HC # ROUTE VEHICLE START END

AGE AT START IN 

WEEKS

23 INHALATION FILTERED AIR 06/25/05 10/28/05 624 ORAL CORN OIL 10/26/05 12/07/05 725 ORAL CORN OIL 12/21/05 02/01/06 726 INHALATION FILTERED AIR 08/02/05 11/04/05 827 ORAL DIET 12/01/04 03/02/05 728 ORAL CORN OIL 03/22/05 05/04/05 729 ORAL DIET 04/18/06 07/21/05 6

Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control

Study Table

Crl:CD(SD) Rats Page 2 of 66

Crl:CD(SD) Rat Subchronic FOB HC v.1.1

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

1 HOME CAGE OBSERVATIONS

1

POSTURE

1 SITTING OR STANDING NORMALLY 93 5 59 19 1 6 -

2 ASLEEP, LYING ON SIDE OR CURLED UP 48 4 22 6 3 1 -3 ALERT, ORIENTED TOWARD OBSERVER 10 1 27 9 6 3 -4 SITTING, HEAD HELD LOW 2 0 0 1 0 0 -5 FLATTENED, LIMBS MAY BE EXTENDED 0 0 0 0 0 0 -8 REARING 0 0 1 0 0 0 -

2

CONVULSIONS - CLONIC

1 ABSENT 153 10 108 35 10 10 -

3

CONVULSIONS - TONIC

1 ABSENT 153 10 108 35 10 10 -

4

TREMORS

1 NONE 153 10 108 35 10 10 -2 SLIGHT (1.5 MM) 0 0 0 0 0 0 -

5

BITING

1 NONE 153 10 107 35 10 10 -2 BITING OF CAGE 0 0 0 0 0 0 -3 BITING OF SELF 0 0 1 0 0 0 -

Crl:CD(SD) Rats Page 3 of 66

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4

49

10 2

107 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Males

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

HOME CAGE OBSERVATIONS

POSTURE

18 54 5 6 3 1 SITTING OR STANDING NORMALLY -

9 24 3 1 2 2 ASLEEP, LYING ON SIDE OR CURLED UP -

22 27 2 3 5 3 ALERT, ORIENTED TOWARD OBSERVER -

00 0 0 0 4 SITTING, HEAD HELD LOW -

00 0 0 0 5 FLATTENED, LIMBS MAY BE EXTENDED -

46 0 1 0 8 REARING -

CONVULSIONS - CLONIC

49 107 10 10 10 1 ABSENT -

CONVULSIONS - TONIC

49 107 10 10 10 1 ABSENT -

TREMORS

49 107 10 10 10 1 NONE -

00 0 0 0 2 SLIGHT (1.5 MM) -

BITING

49 107 10 10 10 1 NONE -

00 0 0 0 2 BITING OF CAGE -00 0 0 0 3 BITING OF SELF -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

1 HOME CAGE OBSERVATIONS

6

PALPEBRAL CLOSURE

1 EYELIDS WIDE OPEN 107 8 87 30 7 9 -2 EYELIDS SLIGHTLY DROOPING 7 1 2 0 1 0 -3 DROOPING EYELIDS (HALF CLOSED) 9 1 6 2 2 0 -4 EYELIDS COMPLETELY SHUT 30 0 13 3 0 1 -

7

FECES CONSISTENCY

1 PELLETS 134 8 84 26 6 8 -2 PELLETS, PARTIALLY FORMED 0 0 0 1 0 0 -4 PELLETS ABSENT 19 2 24 8 4 2 -

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4

49

10 2

107 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Males

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

HOME CAGE OBSERVATIONS

PALPEBRAL CLOSURE

43 79 6 8 7 1 EYELIDS WIDE OPEN -

24 1 0 2 2 EYELIDS SLIGHTLY DROOPING -

06 2 1 0 3 DROOPING EYELIDS (HALF CLOSED) -

4 18 1 1 1 4 EYELIDS COMPLETELY SHUT -

FECES CONSISTENCY

29 59 4 9 5 1 PELLETS -

01 0 0 0 2 PELLETS, PARTIALLY FORMED -

20 47 6 1 5 4 PELLETS ABSENT -

Crl:CD(SD) Rats Page 6 of 66

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

2 HANDLING OBSERVATIONS

1

EASE OF REMOVAL FROM CAGE

1 VERY EASY 120 4 88 28 6 4 -2 EASY 27 6 19 7 4 6 -3 MODERATELY DIFFICULT 1 0 1 0 0 0 -5 DIFFICULT 5 0 0 0 0 0 -6 VERY DIFFICULT 0 0 0 0 0 0 -

2

EASE OF HANDLING ANIMAL IN HAND

1 LOW 153 10 101 33 10 8 -2 MODERATELY LOW 0 0 7 2 0 2 -4 HIGH 0 0 0 0 0 0 -

3

LACRIMATION

1 NONE 153 10 108 35 10 10 -2 SLIGHT 0 0 0 0 0 0 -

4

CHROMODACRYORRHEA

1 ABSENT 153 10 108 35 10 10 -

5

SALIVATION

1 NONE 153 10 108 35 10 10 -2 SLIGHT 0 0 0 0 0 0 -

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4

49

10 2

107 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Males

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

HANDLING OBSERVATIONS

EASE OF REMOVAL FROM CAGE

32 94 10 8 9 1 VERY EASY -

17 11 0 2 0 2 EASY -

01 0 0 1 3 MODERATELY DIFFICULT -

00 0 0 0 5 DIFFICULT -

01 0 0 0 6 VERY DIFFICULT -

EASE OF HANDLING ANIMAL IN HAND

46 101 10 10 10 1 LOW -

35 0 0 0 2 MODERATELY LOW -01 0 0 0 4 HIGH -

LACRIMATION

49 107 10 10 10 1 NONE -

00 0 0 0 2 SLIGHT -

CHROMODACRYORRHEA

49 107 10 10 10 1 ABSENT -

SALIVATION

49 106 10 10 10 1 NONE -

01 0 0 0 2 SLIGHT -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

2 HANDLING OBSERVATIONS

6

PILOERECTION

1 NONE 153 9 107 35 9 10 -2 SLIGHT 0 1 1 0 1 0 -

7

FUR APPEARANCE

1 NORMAL: CLEAN AND GROOMED 153 9 108 35 10 10 -2 SLIGHTLY SOILED 0 1 0 0 0 0 -

8

PALPEBRAL CLOSURE

1 EYELIDS WIDE OPEN 153 10 108 35 10 10 -

9

RESPIRATORY RATE

1 NORMAL: BY OBSERVATION (80-110/MIN.) 153 10 108 35 10 10 -

10

RESPIRATORY CHARACTER

1 NORMAL 153 10 108 35 10 10 -

11

RED DEPOSITS - EYES

1 PRESENT 1 0 4 1 0 0 -2 ABSENT 152 10 104 34 10 10 -

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4

49

10 2

107 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Males

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

HANDLING OBSERVATIONS

PILOERECTION

49 102 10 10 10 1 NONE -

05 0 0 0 2 SLIGHT -

FUR APPEARANCE

48 101 8 10 10 1 NORMAL: CLEAN AND GROOMED -

16 2 0 0 2 SLIGHTLY SOILED -

PALPEBRAL CLOSURE

49 107 10 10 10 1 EYELIDS WIDE OPEN -

RESPIRATORY RATE

49 107 10 10 10 1 NORMAL: BY OBSERVATION (80-110/MIN.) -

RESPIRATORY CHARACTER

49 107 10 10 10 1 NORMAL -

RED DEPOSITS - EYES

25 1 0 0 1 PRESENT -

47 102 9 10 10 2 ABSENT -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

2 HANDLING OBSERVATIONS

12

RED DEPOSITS - NOSE

1 PRESENT 8 1 6 1 0 0 -2 ABSENT 145 9 102 34 10 10 -

13

RED DEPOSITS - MOUTH

2 ABSENT 153 10 108 35 10 10 -

14

CRUSTY DEPOSITS - EYES

1 PRESENT 0 0 2 0 0 0 -2 ABSENT 153 10 106 35 10 10 -

15

CRUSTY DEPOSITS - NOSE

1 PRESENT 1 0 4 0 0 0 -2 ABSENT 152 10 104 35 10 10 -

16

CRUSTY DEPOSITS - MOUTH

1 PRESENT 0 0 0 0 0 0 -2 ABSENT 153 10 108 35 10 10 -

17

MUCOUS MEMBRANES - COLOR

1 PINK 153 10 108 35 10 10 -2 PALE 0 0 0 0 0 0 -

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4

49

10 2

107 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Males

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

HANDLING OBSERVATIONS

RED DEPOSITS - NOSE

12 0 0 0 1 PRESENT -

48 105 10 10 10 2 ABSENT -

RED DEPOSITS - MOUTH

49 107 10 10 10 2 ABSENT -

CRUSTY DEPOSITS - EYES

04 1 0 0 1 PRESENT -

49 103 9 10 10 2 ABSENT -

CRUSTY DEPOSITS - NOSE

04 0 0 0 1 PRESENT -

49 103 10 10 10 2 ABSENT -

CRUSTY DEPOSITS - MOUTH

00 0 0 0 1 PRESENT -

49 107 10 10 10 2 ABSENT -

MUCOUS MEMBRANES - COLOR

49 107 10 10 10 1 PINK -

00 0 0 0 2 PALE -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

2 HANDLING OBSERVATIONS

18

EYES - COLOR

1 PINK 153 10 108 35 10 10 -

19

SKIN - COLOR

1 PINK 153 10 108 35 10 10 -

20

EYE PROMINENCE

1 NORMAL 153 10 108 35 10 10 -2 EXOPHTHALMUS 0 0 0 0 0 0 -

21

MUSCLE TONE

1 MUSCLE IS FIRM BUT NOT HARD (NORMAL 153 10 108 35 10 10 -2 MUSCLE IS SOFT AND FLABBY 0 0 0 0 0 0 -3 MUSCLE IS TENSE AND HARD 0 0 0 0 0 0 -

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4

49

10 2

107 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Males

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

HANDLING OBSERVATIONS

EYES - COLOR

49 107 10 10 10 1 PINK -

SKIN - COLOR

49 107 10 10 10 1 PINK -

EYE PROMINENCE

49 106 10 10 10 1 NORMAL -

01 0 0 0 2 EXOPHTHALMUS -

MUSCLE TONE

49 107 10 10 10 1 MUSCLE IS FIRM BUT NOT HARD (NORMAL -

00 0 0 0 2 MUSCLE IS SOFT AND FLABBY -00 0 0 0 3 MUSCLE IS TENSE AND HARD -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

3 OPEN FIELD OBSERVATIONS

1

MOBILITY

1 NORMAL 153 10 108 35 10 10 -2 SLIGHTLY IMPAIRED 0 0 0 0 0 0 -

2

GAIT

1 NORMAL 153 10 106 35 10 10 -2 WALKS ON TIPTOES 0 0 0 0 0 0 -4 HINDLIMBS SPLAYED OR DRAGGING 0 0 1 0 0 0 -5 HUNCHED BODY, BOTTOM UP, NOSE HELD 0 0 1 0 0 0 -

3

CONVULSIONS - CLONIC

1 ABSENT 153 10 108 35 10 10 -

4

CONVULSIONS - TONIC

1 ABSENT 153 10 108 35 10 10 -

5

TREMORS

1 NONE 153 10 107 35 10 10 -2 SLIGHT (1.5MM) 0 0 1 0 0 0 -

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4

49

10 2

107 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Males

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

OPEN FIELD OBSERVATIONS

MOBILITY

49 107 9 10 10 1 NORMAL -

00 1 0 0 2 SLIGHTLY IMPAIRED -

GAIT

49 107 9 10 10 1 NORMAL -

00 0 0 0 2 WALKS ON TIPTOES -00 0 0 0 4 HINDLIMBS SPLAYED OR DRAGGING -

00 1 0 0 5 HUNCHED BODY, BOTTOM UP, NOSE HELD -

CONVULSIONS - CLONIC

49 107 10 10 10 1 ABSENT -

CONVULSIONS - TONIC

49 107 10 10 10 1 ABSENT -

TREMORS

49 106 10 10 10 1 NONE -

01 0 0 0 2 SLIGHT (1.5MM) -

Crl:CD(SD) Rats Page 16 of 66

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

3 OPEN FIELD OBSERVATIONS

6

GAIT SCORE

1 NORMAL 153 10 107 35 10 10 -2 SLIGHT IMPAIRMENT, BUT DEFINITE 0 0 1 0 0 0 -3 CONSIDERABLE IMPAIRMENT, WITHOUT F 0 0 0 0 0 0 -

7

AROUSAL

1 VERY LOW 0 0 0 1 0 0 -2 LOW 2 5 4 4 0 0 -3 NORMAL 151 5 104 30 10 10 -4 SOMEWHAT HIGH 0 0 0 0 0 0 -

8

BIZARRE/STEREOTYPIC BEHAVIOR

1 NONE 153 10 108 34 10 10 -9 CIRCLING 0 0 0 0 0 0 -

11 RETROPULSION 0 0 0 1 0 0 -

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4

49

10 2

107 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Males

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

OPEN FIELD OBSERVATIONS

GAIT SCORE

49 107 9 10 10 1 NORMAL -

00 1 0 0 2 SLIGHT IMPAIRMENT, BUT DEFINITE -

00 0 0 0 3 CONSIDERABLE IMPAIRMENT, WITHOUT F -

AROUSAL

00 0 0 0 1 VERY LOW -

14 1 0 0 2 LOW -

48 103 9 10 10 3 NORMAL -

00 0 0 0 4 SOMEWHAT HIGH -

BIZARRE/STEREOTYPIC BEHAVIOR

49 107 10 10 10 1 NONE -

00 0 0 0 9 CIRCLING -00 0 0 0 11 RETROPULSION -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

3 OPEN FIELD OBSERVATIONS

1

TIME TO FIRST STEP (seconds)

0.4 0.7 0.6 0.4 0.7 0.7 MEAN

S.D.MINMAX

0.12 0.21 0.51 0.17 0.10 0.00

0.2 0.6 0.3 0.2 0.6 0.70.6 0.9 2.4 0.6 0.7 0.7

2

REARING

5.8 2.8 5.2 5.4 5.4 9.2 MEAN

S.D.MINMAX

1.54 3.68 2.31 2.01 1.13 0.00

3.0 0.2 1.4 2.8 4.6 9.28.8 5.4 8.4 8.4 6.2 9.2

3

BACKING

0.0 0.0 0.0 0.0 0.0 0.0 MEAN

S.D.MINMAX

0.04 0.00 0.06 0.08 0.00 0.00

0.0 0.0 0.0 0.0 0.0 0.00.2 0.0 0.2 0.2 0.0 0.0

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4

49

10 2

107 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

7 12 16 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

13 - 14 18 - 19 23

Males

13

1

10

19-20

25

1

10

32

3 OPEN FIELD OBSERVATIONS

1

TIME TO FIRST STEP (seconds)

0.4 0.4 0.4 MEAN

S.D.MINMAX

0.17 0.07 0.06

0.2 0.3 0.30.6 0.5 0.4

0.5

0.00

0.50.5

0.4

0.00

0.40.4

2

REARING

7.3 6.4 3.7 MEAN

S.D.MINMAX

2.36 2.00 0.71

3.8 4.0 3.29.0 9.6 4.2

7.7

0.00

7.77.7

6.1

0.00

6.16.1

3

BACKING

0.0 0.1 0.0 MEAN

S.D.MINMAX

0.00 0.32 0.00

0.0 0.0 0.00.0 1.0 0.0

0.0

0.00

0.00.0

0.0

0.00

0.00.0

Crl:CD(SD) Rats Page 20 of 66

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

3 OPEN FIELD OBSERVATIONS

4

GROOMING

0.5 0.0 0.2 0.2 0.1 0.0 MEAN

S.D.MINMAX

0.29 0.00 0.20 0.18 0.14 0.00

0.0 0.0 0.0 0.0 0.0 0.01.1 0.0 0.6 0.4 0.2 0.0

5

URINATION

0.7 1.5 1.3 1.0 0.7 1.8 MEAN

S.D.MINMAX

0.45 1.84 0.84 0.59 0.42 0.00

0.0 0.2 0.4 0.2 0.4 1.81.8 2.8 3.4 1.8 1.0 1.8

6

DEFECATION

0.9 1.2 1.0 0.8 0.8 0.3 MEAN

S.D.MINMAX

0.53 0.85 0.42 0.32 1.13 0.00

0.2 0.6 0.4 0.4 0.0 0.31.8 1.8 1.6 1.2 1.6 0.3

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4

49

10 2

107 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

7 12 16 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

13 - 14 18 - 19 23

Males

13

1

10

19-20

25

1

10

32

3 OPEN FIELD OBSERVATIONS

4

GROOMING

0.3 0.3 0.0 MEAN

S.D.MINMAX

0.15 0.20 0.00

0.2 0.0 0.00.5 0.6 0.0

0.2

0.00

0.20.2

0.1

0.00

0.10.1

5

URINATION

1.5 0.9 0.8 MEAN

S.D.MINMAX

0.93 0.47 0.28

0.7 0.2 0.62.6 1.8 1.0

1.2

0.00

1.21.2

0.8

0.00

0.80.8

6

DEFECATION

0.7 0.5 1.0 MEAN

S.D.MINMAX

0.34 0.30 0.00

0.3 0.2 1.01.1 1.1 1.0

1.1

0.00

1.11.1

0.8

0.00

0.80.8

Crl:CD(SD) Rats Page 22 of 66

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

4 SENSORY OBSERVATIONS

1

APPROACH RESPONSE

1 NO REACTION 15 8 12 7 2 0 -2 SLOW APPROACH, SNIFFING OR TURNING 137 2 94 28 8 10 -3 MORE ENERGETIC RESPONSE THAN (2) 1 0 0 0 0 0 -4 FREEZES, ACTUAL MUSCLE CONTRACTION 0 0 1 0 0 0 -5 BIZARRE REACTION: JUMPS, BITES OR AT 0 0 1 0 0 0 -

2

TOUCH RESPONSE

1 NO REACTION 15 2 17 6 0 1 -2 ANIMAL MAY SLOWLY TURN, WALK AWA 138 8 90 29 10 9 -3 MORE ENERGETIC RESPONSE THAN (2) 0 0 0 0 0 0 -4 FREEZES, ACTUAL MUSCLE CONTRACTION 0 0 1 0 0 0 -

3

STARTLE RESPONSE

1 NO REACTION 0 0 2 0 0 1 -2 SLIGHT REACTION 151 9 105 28 10 9 -3 MORE ENERGETIC RESPONSE THAN (2) 2 1 1 7 0 0 -

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4

49

10 2

107 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Males

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

SENSORY OBSERVATIONS

APPROACH RESPONSE

29 0 0 0 1 NO REACTION -

47 98 10 10 10 2 SLOW APPROACH, SNIFFING OR TURNING -

00 0 0 0 3 MORE ENERGETIC RESPONSE THAN (2) -00 0 0 0 4 FREEZES, ACTUAL MUSCLE CONTRACTION -

00 0 0 0 5 BIZARRE REACTION: JUMPS, BITES OR AT -

TOUCH RESPONSE

20 0 2 0 1 NO REACTION -

47 106 10 8 10 2 ANIMAL MAY SLOWLY TURN, WALK AWA -

01 0 0 0 3 MORE ENERGETIC RESPONSE THAN (2) -00 0 0 0 4 FREEZES, ACTUAL MUSCLE CONTRACTION -

STARTLE RESPONSE

00 0 0 0 1 NO REACTION -

46 105 10 10 10 2 SLIGHT REACTION -

32 0 0 0 3 MORE ENERGETIC RESPONSE THAN (2) -

Crl:CD(SD) Rats Page 24 of 66

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

4 SENSORY OBSERVATIONS

4

TAIL PINCH

1 NO REACTION 4 1 3 2 0 1 -2 ANIMAL MAY TURN OR WALK AWAY 127 7 94 24 9 6 -3 MORE ENERGETIC RESPONSE THAN (2) 22 2 11 9 1 3 -

5

OLFACTORY ORIENTATION

1 NO REACTION PRESENT 0 1 7 2 0 0 -2 REACTION PRESENT 153 9 101 33 10 10 -

6

PUPIL RESPONSE

1 NO PUPIL RESPONSE 0 0 2 0 0 0 -2 PUPIL RESPONSE PRESENT 153 10 106 35 10 10 -

7

EYEBLINK RESPONSE

2 EYEBLINK RESPONSE PRESENT 153 10 108 35 10 10 -

8

FORELIMB EXTENSION

1 NO FORELIMB EXTENSION 0 0 0 0 0 0 -2 FORELIMB EXTENSION PRESENT 153 10 108 35 10 10 -

9

HINDLIMB EXTENSION

1 NO HINDLIMB EXTENSION 1 0 0 0 0 0 -2 HINDLIMB EXTENSION PRESENT 152 10 108 35 10 10 -

Crl:CD(SD) Rats Page 25 of 66

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4

49

10 2

107 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Males

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

SENSORY OBSERVATIONS

TAIL PINCH

03 0 0 0 1 NO REACTION -

37 89 9 8 9 2 ANIMAL MAY TURN OR WALK AWAY -

12 15 1 2 1 3 MORE ENERGETIC RESPONSE THAN (2) -

OLFACTORY ORIENTATION

50 0 0 0 1 NO REACTION PRESENT -

44 107 10 10 10 2 REACTION PRESENT -

PUPIL RESPONSE

00 0 0 0 1 NO PUPIL RESPONSE -

49 107 10 10 10 2 PUPIL RESPONSE PRESENT -

EYEBLINK RESPONSE

49 107 10 10 10 2 EYEBLINK RESPONSE PRESENT -

FORELIMB EXTENSION

01 0 0 0 1 NO FORELIMB EXTENSION -

49 106 10 10 10 2 FORELIMB EXTENSION PRESENT -

HINDLIMB EXTENSION

00 0 0 0 1 NO HINDLIMB EXTENSION -

49 107 10 10 10 2 HINDLIMB EXTENSION PRESENT -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

4 SENSORY OBSERVATIONS

10

AIR RIGHTING REFLEX

1 NORMAL 153 10 107 35 10 9 -2 SLIGHTLY UNCOORDINATED 0 0 1 0 0 1 -3 LANDS ON SIDE 0 0 0 0 0 0 -

5 NEUROMUSCULAR OBSERVATIONS

1

HINDLIMB EXTENSOR STRENGTH

2 REDUCED HINDLIMB RESISTANCE 0 1 0 0 0 0 -3 HINDLIMB RESISTANCE PRESENT 153 9 108 35 10 10 -

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4

49

10 2

107 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Males

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

SENSORY OBSERVATIONS

AIR RIGHTING REFLEX

48 102 10 10 9 1 NORMAL -

14 0 0 1 2 SLIGHTLY UNCOORDINATED -

01 0 0 0 3 LANDS ON SIDE -

NEUROMUSCULAR OBSERVATIONS

HINDLIMB EXTENSOR STRENGTH

00 0 0 0 2 REDUCED HINDLIMB RESISTANCE -

49 107 10 10 10 3 HINDLIMB RESISTANCE PRESENT -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

5 NEUROMUSCULAR OBSERVATIONS

1

GRIPSTRENGTH - FORELIMB (g) 

534.0 807.5 735.4 804.2 614.1 675.8 MEAN

S.D.MINMAX

106.71 58.12 151.29 186.80 62.37 0.00

398.5 766.4 482.7 543.4 570.0 675.8771.6 848.6 1056.6 1113.4 658.2 675.8

2

GRIPSTRENGTH - HINDLIMB (g) 

274.0 565.9 439.3 525.0 460.1 389.2 MEAN

S.D.MINMAX

49.01 95.18 93.16 174.96 176.92 0.00164.0 498.6 300.9 380.0 335.0 389.2364.9 633.2 640.0 861.6 585.2 389.2

3

ROTAROD PERFORMANCE (seconds)

90.1 87.3 80.5 83.7 85.3 86.5 MEAN

S.D.MINMAX

16.42 10.20 18.23 18.23 4.84 0.00

62.1 80.1 53.2 70.1 81.9 86.5

120.0 94.5 111.3 120.0 88.7 86.5

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49

10 2

107 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

7 12 16 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

13 - 14 18 - 19 23

Males

13

1

10

19-20

25

1

10

32

5 NEUROMUSCULAR OBSERVATIONS

1

GRIPSTRENGTH - FORELIMB (g) 

759.8 918.1 836.7 MEAN

S.D.MINMAX

179.13 223.86 313.53

501.3 640.2 615.0899.4 1268.4 1058.4

741.8

0.00

741.8741.8

1105.7

0.00

1105.71105.7

2

GRIPSTRENGTH - HINDLIMB (g) 

603.8 555.3 470.1 MEAN

S.D.MINMAX

158.78 203.99 49.36

380.7 340.7 435.2744.4 1005.0 505.0

571.6

0.00

571.6571.6

737.5

0.00

737.5737.5

3

ROTAROD PERFORMANCE (seconds)

81.2 55.5 51.8 MEAN

S.D.MINMAX

22.04 26.06 0.41

57.8 9.1 51.5

107.6 92.9 52.1

50.90.0050.950.9

14.80.0014.814.8

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

5 NEUROMUSCULAR OBSERVATIONS

4

HINDLIMB FOOTSPLAY (mm) 

74.1 87.2 75.6 75.4 77.6 66.5 MEAN

S.D.MINMAX

9.10 3.11 9.28 4.46 0.00 0.0060.2 85.0 59.4 68.8 77.6 66.592.8 89.4 89.6 80.0 77.6 66.5

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4

49

10 2

107 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

7 12 16 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

13 - 14 18 - 19 23

Males

13

1

10

19-20

25

1

10

32

5 NEUROMUSCULAR OBSERVATIONS

4

HINDLIMB FOOTSPLAY (mm) 

72.9 69.0 80.1 MEAN

S.D.MINMAX

17.51 18.48 4.38

49.8 44.2 77.088.4 102.0 83.2

61.40.0061.461.4

77.30.0077.377.3

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Males

6 PHYSIOLOGICAL OBSERVATIONS

1

CATALEPSY (seconds)

0.4 0.5 0.4 0.4 0.3 0.2 MEAN

S.D.MINMAX

0.15 0.10 0.17 0.13 0.18 0.00

0.2 0.4 0.2 0.2 0.2 0.20.8 0.6 0.7 0.5 0.5 0.2

2

BODY TEMPERATURE (oC)

37.9 38.3 38.6 38.0 38.3 38.4 MEAN

S.D.MINMAX

0.72 0.03 0.61 1.16 0.82 0.0036.4 38.3 37.5 36.3 37.7 38.439.2 38.3 40.0 39.3 38.8 38.4

3

BODY WEIGHT (g)

189.6 318.2 355.1 369.2 412.2 439.9 MEAN

S.D.MINMAX

26.18 18.67 25.42 23.43 51.73 0.00148.2 305.0 322.2 347.2 375.7 439.9226.2 331.4 404.0 409.5 448.8 439.9

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49

10 2

107 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

7 12 16 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

13 - 14 18 - 19 23

Males

13

1

10

19-20

25

1

10

32

6 PHYSIOLOGICAL OBSERVATIONS

1

CATALEPSY (seconds)

0.4 0.5 0.8 MEAN

S.D.MINMAX

0.15 0.23 0.79

0.2 0.2 0.20.5 0.9 1.4

0.5

0.00

0.50.5

1.2

0.00

1.21.2

2

BODY TEMPERATURE (oC)

38.2 37.8 38.5 MEAN

S.D.MINMAX

1.03 1.13 0.3336.9 35.2 38.339.1 38.9 38.7

36.40.0036.436.4

35.50.0035.535.5

3

BODY WEIGHT (g)

428.6 517.2 570.2 MEAN

S.D.MINMAX

22.36 30.63 2.19406.2 469.4 568.6458.3 564.0 571.7

565.8

0.00

565.8565.8

601.6

0.00

601.6601.6

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

1 HOME CAGE OBSERVATIONS

1

POSTURE

1 SITTING OR STANDING NORMALLY 98 5 65 15 7 4 -2 ASLEEP, LYING ON SIDE OR CURLED UP 41 1 9 2 1 2 -3 ALERT, ORIENTED TOWARD OBSERVER 12 4 32 18 1 4 -4 SITTING, HEAD HELD LOW 0 0 0 0 0 0 -5 FLATTENED, LIMBS MAY BE EXTENDED 1 0 0 0 0 0 -8 REARING 3 0 8 0 1 0 -

2

CONVULSIONS - CLONIC

1 ABSENT 153 10 108 35 10 10 -

3

CONVULSIONS - TONIC

1 ABSENT 153 10 108 35 10 10 -

4

TREMORS

1 NONE 153 10 107 35 10 10 -2 SLIGHT (1.5 MM) 0 0 1 0 0 0 -

5

BITING

1 NONE 153 10 106 34 10 10 -2 BITING OF CAGE 0 0 2 0 0 0 -3 BITING OF SELF 0 0 0 1 0 0 -

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4

49

10 2

109 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Females

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

HOME CAGE OBSERVATIONS

POSTURE

18 58 3 6 2 1 SITTING OR STANDING NORMALLY -

3 14 0 1 1 2 ASLEEP, LYING ON SIDE OR CURLED UP -

24 36 6 3 7 3 ALERT, ORIENTED TOWARD OBSERVER -

00 0 0 0 4 SITTING, HEAD HELD LOW -

00 0 0 0 5 FLATTENED, LIMBS MAY BE EXTENDED -

11 12 1 1 2 8 REARING -

CONVULSIONS - CLONIC

49 109 10 10 10 1 ABSENT -

CONVULSIONS - TONIC

49 109 10 10 10 1 ABSENT -

TREMORS

49 108 10 10 10 1 NONE -

01 0 0 0 2 SLIGHT (1.5 MM) -

BITING

49 108 9 10 9 1 NONE -

01 0 0 1 2 BITING OF CAGE -00 1 0 0 3 BITING OF SELF -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

1 HOME CAGE OBSERVATIONS

6

PALPEBRAL CLOSURE

1 EYELIDS WIDE OPEN 111 9 97 32 9 8 -2 EYELIDS SLIGHTLY DROOPING 10 0 5 1 0 0 -3 DROOPING EYELIDS (HALF CLOSED) 5 0 2 0 1 0 -4 EYELIDS COMPLETELY SHUT 27 1 4 2 0 2 -

7

FECES CONSISTENCY

1 PELLETS 128 4 64 15 5 9 -2 PELLETS, PARTIALLY FORMED 0 0 1 0 0 0 -4 PELLETS ABSENT 25 6 43 20 5 1 -

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4

49

10 2

109 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Females

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

HOME CAGE OBSERVATIONS

PALPEBRAL CLOSURE

47 92 10 9 8 1 EYELIDS WIDE OPEN -

14 0 0 0 2 EYELIDS SLIGHTLY DROOPING -

04 0 0 1 3 DROOPING EYELIDS (HALF CLOSED) -

19 0 1 1 4 EYELIDS COMPLETELY SHUT -

FECES CONSISTENCY

17 71 5 4 3 1 PELLETS -

01 0 0 0 2 PELLETS, PARTIALLY FORMED -

32 37 5 6 7 4 PELLETS ABSENT -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

2 HANDLING OBSERVATIONS

1

EASE OF REMOVAL FROM CAGE

1 VERY EASY 119 6 96 27 4 6 -2 EASY 29 4 12 8 6 4 -3 MODERATELY DIFFICULT 3 0 0 0 0 0 -5 DIFFICULT 2 0 0 0 0 0 -6 VERY DIFFICULT 0 0 0 0 0 0 -

2

EASE OF HANDLING ANIMAL IN HAND

1 LOW 145 9 104 33 10 9 -2 MODERATELY LOW 8 1 4 2 0 1 -4 HIGH 0 0 0 0 0 0 -

3

LACRIMATION

1 NONE 153 10 107 35 10 10 -2 SLIGHT 0 0 1 0 0 0 -

4

CHROMODACRYORRHEA

1 ABSENT 153 10 108 35 10 10 -

5

SALIVATION

1 NONE 153 10 108 35 10 10 -2 SLIGHT 0 0 0 0 0 0 -

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4

49

10 2

109 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Females

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

HANDLING OBSERVATIONS

EASE OF REMOVAL FROM CAGE

28 99 9 10 10 1 VERY EASY -

20 8 0 0 0 2 EASY -

12 0 0 0 3 MODERATELY DIFFICULT -

00 1 0 0 5 DIFFICULT -

00 0 0 0 6 VERY DIFFICULT -

EASE OF HANDLING ANIMAL IN HAND

49 102 10 10 10 1 LOW -

07 0 0 0 2 MODERATELY LOW -00 0 0 0 4 HIGH -

LACRIMATION

49 109 10 10 10 1 NONE -

00 0 0 0 2 SLIGHT -

CHROMODACRYORRHEA

49 109 10 10 10 1 ABSENT -

SALIVATION

49 109 10 10 10 1 NONE -

00 0 0 0 2 SLIGHT -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

2 HANDLING OBSERVATIONS

6

PILOERECTION

1 NONE 153 10 108 35 10 10 -2 SLIGHT 0 0 0 0 0 0 -

7

FUR APPEARANCE

1 NORMAL: CLEAN AND GROOMED 153 10 108 35 10 10 -2 SLIGHTLY SOILED 0 0 0 0 0 0 -

8

PALPEBRAL CLOSURE

1 EYELIDS WIDE OPEN 153 10 108 35 10 10 -

9

RESPIRATORY RATE

1 NORMAL: BY OBSERVATION (80-110/MIN.) 153 10 108 35 10 10 -

10

RESPIRATORY CHARACTER

1 NORMAL 153 10 108 35 10 10 -

11

RED DEPOSITS - EYES

1 PRESENT 0 0 1 0 0 0 -2 ABSENT 153 10 107 35 10 10 -

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4

49

10 2

109 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Females

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

HANDLING OBSERVATIONS

PILOERECTION

49 107 10 10 10 1 NONE -

02 0 0 0 2 SLIGHT -

FUR APPEARANCE

44 108 10 10 10 1 NORMAL: CLEAN AND GROOMED -

51 0 0 0 2 SLIGHTLY SOILED -

PALPEBRAL CLOSURE

49 109 10 10 10 1 EYELIDS WIDE OPEN -

RESPIRATORY RATE

49 109 10 10 10 1 NORMAL: BY OBSERVATION (80-110/MIN.) -

RESPIRATORY CHARACTER

49 109 10 10 10 1 NORMAL -

RED DEPOSITS - EYES

01 1 0 1 1 PRESENT -

49 108 9 10 9 2 ABSENT -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

2 HANDLING OBSERVATIONS

12

RED DEPOSITS - NOSE

1 PRESENT 4 0 0 0 0 0 -2 ABSENT 149 10 108 35 10 10 -

13

RED DEPOSITS - MOUTH

2 ABSENT 153 10 108 35 10 10 -

14

CRUSTY DEPOSITS - EYES

1 PRESENT 0 0 0 0 0 0 -2 ABSENT 153 10 108 35 10 10 -

15

CRUSTY DEPOSITS - NOSE

1 PRESENT 0 0 2 0 0 0 -2 ABSENT 153 10 106 35 10 10 -

16

CRUSTY DEPOSITS - MOUTH

1 PRESENT 0 0 0 0 0 0 -2 ABSENT 153 10 108 35 10 10 -

17

MUCOUS MEMBRANES - COLOR

1 PINK 153 10 108 35 10 10 -2 PALE 0 0 0 0 0 0 -

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4

49

10 2

109 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Females

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

HANDLING OBSERVATIONS

RED DEPOSITS - NOSE

02 0 0 0 1 PRESENT -

49 107 10 10 10 2 ABSENT -

RED DEPOSITS - MOUTH

49 109 10 10 10 2 ABSENT -

CRUSTY DEPOSITS - EYES

00 0 0 1 1 PRESENT -

49 109 10 10 9 2 ABSENT -

CRUSTY DEPOSITS - NOSE

03 0 0 0 1 PRESENT -

49 106 10 10 10 2 ABSENT -

CRUSTY DEPOSITS - MOUTH

00 0 0 0 1 PRESENT -

49 109 10 10 10 2 ABSENT -

MUCOUS MEMBRANES - COLOR

48 109 10 10 10 1 PINK -

10 0 0 0 2 PALE -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

2 HANDLING OBSERVATIONS

18

EYES - COLOR

1 PINK 153 10 108 35 10 10 -

19

SKIN - COLOR

1 PINK 153 10 108 35 10 10 -

20

EYE PROMINENCE

1 NORMAL 153 10 106 35 10 10 -2 EXOPHTHALMUS 0 0 2 0 0 0 -

21

MUSCLE TONE

1 MUSCLE IS FIRM BUT NOT HARD (NORMAL 152 10 108 35 10 10 -2 MUSCLE IS SOFT AND FLABBY 1 0 0 0 0 0 -3 MUSCLE IS TENSE AND HARD 0 0 0 0 0 0 -

Crl:CD(SD) Rats Page 45 of 66

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4

49

10 2

109 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Females

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

HANDLING OBSERVATIONS

EYES - COLOR

49 109 10 10 10 1 PINK -

SKIN - COLOR

49 109 10 10 10 1 PINK -

EYE PROMINENCE

49 106 9 10 10 1 NORMAL -

03 1 0 0 2 EXOPHTHALMUS -

MUSCLE TONE

49 107 10 10 10 1 MUSCLE IS FIRM BUT NOT HARD (NORMAL -

00 0 0 0 2 MUSCLE IS SOFT AND FLABBY -02 0 0 0 3 MUSCLE IS TENSE AND HARD -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

3 OPEN FIELD OBSERVATIONS

1

MOBILITY

1 NORMAL 153 10 108 35 10 10 -2 SLIGHTLY IMPAIRED 0 0 0 0 0 0 -

2

GAIT

1 NORMAL 153 10 108 35 10 10 -2 WALKS ON TIPTOES 0 0 0 0 0 0 -4 HINDLIMBS SPLAYED OR DRAGGING 0 0 0 0 0 0 -5 HUNCHED BODY, BOTTOM UP, NOSE HELD 0 0 0 0 0 0 -

3

CONVULSIONS - CLONIC

1 ABSENT 153 10 108 35 10 10 -

4

CONVULSIONS - TONIC

1 ABSENT 153 10 108 35 10 10 -

5

TREMORS

1 NONE 153 10 107 35 10 10 -2 SLIGHT (1.5MM) 0 0 1 0 0 0 -

Crl:CD(SD) Rats Page 47 of 66

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4

49

10 2

109 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Females

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

OPEN FIELD OBSERVATIONS

MOBILITY

49 109 10 10 10 1 NORMAL -

00 0 0 0 2 SLIGHTLY IMPAIRED -

GAIT

49 108 10 10 10 1 NORMAL -

01 0 0 0 2 WALKS ON TIPTOES -00 0 0 0 4 HINDLIMBS SPLAYED OR DRAGGING -

02 0 0 0 5 HUNCHED BODY, BOTTOM UP, NOSE HELD -

CONVULSIONS - CLONIC

49 109 10 10 10 1 ABSENT -

CONVULSIONS - TONIC

49 109 10 10 10 1 ABSENT -

TREMORS

49 109 10 10 10 1 NONE -

00 0 0 0 2 SLIGHT (1.5MM) -

Crl:CD(SD) Rats Page 48 of 66

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

3 OPEN FIELD OBSERVATIONS

6

GAIT SCORE

1 NORMAL 153 10 108 35 10 9 -2 SLIGHT IMPAIRMENT, BUT DEFINITE 0 0 0 0 0 0 -3 CONSIDERABLE IMPAIRMENT, WITHOUT F 0 0 0 0 0 1 -

7

AROUSAL

1 VERY LOW 0 0 0 0 0 0 -2 LOW 0 1 1 0 0 0 -3 NORMAL 153 9 105 35 9 10 -4 SOMEWHAT HIGH 0 0 2 0 1 0 -

8

BIZARRE/STEREOTYPIC BEHAVIOR

1 NONE 153 10 107 35 10 10 -9 CIRCLING 0 0 1 0 0 0 -

11 RETROPULSION 0 0 0 0 0 0 -

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4

49

10 2

109 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Females

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

OPEN FIELD OBSERVATIONS

GAIT SCORE

49 109 10 10 10 1 NORMAL -

00 0 0 0 2 SLIGHT IMPAIRMENT, BUT DEFINITE -

00 0 0 0 3 CONSIDERABLE IMPAIRMENT, WITHOUT F -

AROUSAL

00 0 0 0 1 VERY LOW -

00 0 0 0 2 LOW -

49 109 9 10 10 3 NORMAL -

00 1 0 0 4 SOMEWHAT HIGH -

BIZARRE/STEREOTYPIC BEHAVIOR

49 109 10 10 10 1 NONE -

00 0 0 0 9 CIRCLING -00 0 0 0 11 RETROPULSION -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

3 OPEN FIELD OBSERVATIONS

1

TIME TO FIRST STEP (seconds)

0.3 0.5 0.4 0.4 0.3 0.5 MEAN

S.D.MINMAX

0.08 0.14 0.11 0.12 0.04 0.00

0.2 0.4 0.3 0.2 0.3 0.50.5 0.6 0.6 0.5 0.3 0.5

2

REARING

7.5 10.9 9.0 11.5 9.2 11.6 MEAN

S.D.MINMAX

1.68 5.23 3.22 3.04 0.00 0.00

4.6 7.2 3.6 7.2 9.2 11.69.8 14.6 14.8 15.8 9.2 11.6

3

BACKING

0.0 0.0 0.0 0.0 0.0 0.0 MEAN

S.D.MINMAX

0.03 0.00 0.00 0.00 0.00 0.00

0.0 0.0 0.0 0.0 0.0 0.00.1 0.0 0.0 0.0 0.0 0.0

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4

49

10 2

109 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

7 12 16 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

13 - 14 18 - 19 23

Females

13

1

10

19-20

25

1

10

32

3 OPEN FIELD OBSERVATIONS

1

TIME TO FIRST STEP (seconds)

0.3 0.4 0.3 MEAN

S.D.MINMAX

0.08 0.08 0.01

0.2 0.3 0.30.4 0.5 0.3

0.4

0.00

0.40.4

0.4

0.00

0.40.4

2

REARING

10.1 10.5 10.1 MEAN

S.D.MINMAX

2.34 1.54 5.80

7.7 7.9 6.0

13.3 12.7 14.2

13.40.0013.413.4

8.1

0.00

8.18.1

3

BACKING

0.0 0.0 0.0 MEAN

S.D.MINMAX

0.00 0.00 0.00

0.0 0.0 0.00.0 0.0 0.0

0.0

0.00

0.00.0

0.0

0.00

0.00.0

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

3 OPEN FIELD OBSERVATIONS

4

GROOMING

0.5 0.1 0.3 0.3 1.0 0.1 MEAN

S.D.MINMAX

0.38 0.14 0.29 0.36 1.13 0.00

0.0 0.0 0.0 0.0 0.2 0.11.4 0.2 0.9 0.9 1.8 0.1

5

URINATION

0.5 0.2 0.4 0.2 0.0 1.2 MEAN

S.D.MINMAX

0.68 0.00 0.59 0.20 0.00 0.00

0.0 0.2 0.0 0.0 0.0 1.23.2 0.2 2.2 0.4 0.0 1.2

6

DEFECATION

0.2 0.0 0.0 0.0 0.2 0.0 MEAN

S.D.MINMAX

0.27 0.00 0.08 0.00 0.28 0.00

0.0 0.0 0.0 0.0 0.0 0.00.8 0.0 0.2 0.0 0.4 0.0

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4

49

10 2

109 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

7 12 16 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

13 - 14 18 - 19 23

Females

13

1

10

19-20

25

1

10

32

3 OPEN FIELD OBSERVATIONS

4

GROOMING

0.3 0.4 0.4 MEAN

S.D.MINMAX

0.29 0.26 0.00

0.0 0.0 0.40.7 0.8 0.4

1.2

0.00

1.21.2

0.2

0.00

0.20.2

5

URINATION

0.2 0.3 0.1 MEAN

S.D.MINMAX

0.22 0.21 0.14

0.0 0.0 0.00.5 0.6 0.2

0.5

0.00

0.50.5

1.2

0.00

1.21.2

6

DEFECATION

0.1 0.1 0.0 MEAN

S.D.MINMAX

0.09 0.24 0.00

0.0 0.0 0.00.2 0.7 0.0

0.0

0.00

0.00.0

0.3

0.00

0.30.3

Crl:CD(SD) Rats Page 54 of 66

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

4 SENSORY OBSERVATIONS

1

APPROACH RESPONSE

1 NO REACTION 10 2 10 4 2 0 -2 SLOW APPROACH, SNIFFING OR TURNING 141 8 97 30 7 10 -3 MORE ENERGETIC RESPONSE THAN (2) 2 0 1 1 1 0 -4 FREEZES, ACTUAL MUSCLE CONTRACTION 0 0 0 0 0 0 -5 BIZARRE REACTION: JUMPS, BITES OR AT 0 0 0 0 0 0 -

2

TOUCH RESPONSE

1 NO REACTION 5 5 10 2 1 0 -2 ANIMAL MAY SLOWLY TURN, WALK AWA 146 5 95 32 9 10 -3 MORE ENERGETIC RESPONSE THAN (2) 2 0 3 1 0 0 -4 FREEZES, ACTUAL MUSCLE CONTRACTION 0 0 0 0 0 0 -

3

STARTLE RESPONSE

1 NO REACTION 0 1 1 1 0 4 -2 SLIGHT REACTION 147 8 100 27 10 6 -3 MORE ENERGETIC RESPONSE THAN (2) 6 1 7 7 0 0 -

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4

49

10 2

109 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Females

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

SENSORY OBSERVATIONS

APPROACH RESPONSE

05 0 0 0 1 NO REACTION -

47 104 10 10 10 2 SLOW APPROACH, SNIFFING OR TURNING -

20 0 0 0 3 MORE ENERGETIC RESPONSE THAN (2) -00 0 0 0 4 FREEZES, ACTUAL MUSCLE CONTRACTION -

00 0 0 0 5 BIZARRE REACTION: JUMPS, BITES OR AT -

TOUCH RESPONSE

06 0 0 0 1 NO REACTION -

48 103 10 10 10 2 ANIMAL MAY SLOWLY TURN, WALK AWA -

10 0 0 0 3 MORE ENERGETIC RESPONSE THAN (2) -

00 0 0 0 4 FREEZES, ACTUAL MUSCLE CONTRACTION -

STARTLE RESPONSE

01 0 0 0 1 NO REACTION -

45 106 10 10 10 2 SLIGHT REACTION -

42 0 0 0 3 MORE ENERGETIC RESPONSE THAN (2) -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

4 SENSORY OBSERVATIONS

4

TAIL PINCH

1 NO REACTION 2 1 6 1 0 0 -2 ANIMAL MAY TURN OR WALK AWAY 122 5 78 29 6 5 -3 MORE ENERGETIC RESPONSE THAN (2) 29 4 24 5 4 5 -

5

OLFACTORY ORIENTATION

1 NO REACTION PRESENT 1 2 2 1 0 0 -2 REACTION PRESENT 152 8 106 34 10 10 -

6

PUPIL RESPONSE

1 NO PUPIL RESPONSE 0 0 3 0 0 0 -2 PUPIL RESPONSE PRESENT 153 10 105 35 10 10 -

7

EYEBLINK RESPONSE

2 EYEBLINK RESPONSE PRESENT 153 10 108 35 10 10 -

8

FORELIMB EXTENSION

1 NO FORELIMB EXTENSION 1 0 0 0 1 0 -2 FORELIMB EXTENSION PRESENT 152 10 108 35 9 10 -

9

HINDLIMB EXTENSION

1 NO HINDLIMB EXTENSION 0 0 0 0 1 1 -2 HINDLIMB EXTENSION PRESENT 153 10 108 35 9 9 -

Crl:CD(SD) Rats Page 57 of 66

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4

49

10 2

109 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Females

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

SENSORY OBSERVATIONS

TAIL PINCH

07 0 0 0 1 NO REACTION -

45 87 8 10 8 2 ANIMAL MAY TURN OR WALK AWAY -

4 15 2 0 2 3 MORE ENERGETIC RESPONSE THAN (2) -

OLFACTORY ORIENTATION

31 0 0 0 1 NO REACTION PRESENT -

46 108 10 10 10 2 REACTION PRESENT -

PUPIL RESPONSE

00 0 0 0 1 NO PUPIL RESPONSE -

49 109 10 10 10 2 PUPIL RESPONSE PRESENT -

EYEBLINK RESPONSE

49 109 10 10 10 2 EYEBLINK RESPONSE PRESENT -

FORELIMB EXTENSION

00 0 0 0 1 NO FORELIMB EXTENSION -

49 109 10 10 10 2 FORELIMB EXTENSION PRESENT -

HINDLIMB EXTENSION

00 0 0 0 1 NO HINDLIMB EXTENSION -

49 109 10 10 10 2 HINDLIMB EXTENSION PRESENT -

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

4 SENSORY OBSERVATIONS

10

AIR RIGHTING REFLEX

1 NORMAL 152 10 108 35 10 10 -2 SLIGHTLY UNCOORDINATED 1 0 0 0 0 0 -3 LANDS ON SIDE 0 0 0 0 0 0 -

5 NEUROMUSCULAR OBSERVATIONS

1

HINDLIMB EXTENSOR STRENGTH

2 REDUCED HINDLIMB RESISTANCE 0 0 0 0 0 0 -3 HINDLIMB RESISTANCE PRESENT 153 10 108 35 10 10 -

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4

49

10 2

109 10

7 12 16

13 - 14 18 - 19 23

1

13

10

19 - 20

1

25

10

32

TIME POINT (STUDY WEEK)NUMBER OF STUDIESNUMBER OF ANIMALS TESTEDAGE RANGE OF ANIMALS TESTED

Females

 Subchronic - Functional Observation Battery

WIL Research Laboratories - Historical Control Data

SENSORY OBSERVATIONS

AIR RIGHTING REFLEX

48 107 10 10 10 1 NORMAL -

11 0 0 0 2 SLIGHTLY UNCOORDINATED -

01 0 0 0 3 LANDS ON SIDE -

NEUROMUSCULAR OBSERVATIONS

HINDLIMB EXTENSOR STRENGTH

00 0 0 0 2 REDUCED HINDLIMB RESISTANCE -

49 109 10 10 10 3 HINDLIMB RESISTANCE PRESENT -

Crl:CD(SD) Rats Page 60 of 66

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

5 NEUROMUSCULAR OBSERVATIONS

1

GRIPSTRENGTH - FORELIMB (g) 

502.7 660.9 626.9 658.6 543.2 651.6 MEAN

S.D.MINMAX

100.97 62.37 121.62 169.93 145.95 0.00

364.8 616.8 395.0 415.0 440.0 651.6734.7 705.0 801.8 876.6 646.4 651.6

2

GRIPSTRENGTH - HINDLIMB (g) 

271.9 480.1 399.9 478.3 427.4 288.3 MEAN

S.D.MINMAX

50.52 96.59 101.42 144.53 170.84 0.00192.9 411.8 285.4 301.6 306.6 288.3388.4 548.4 599.0 729.8 548.2 288.3

3

ROTAROD PERFORMANCE (seconds)

72.4 75.4 83.9 84.4 87.8 76.1 MEAN

S.D.MINMAX

20.19 6.75 19.37 20.29 15.00 0.00

32.3 70.6 56.8 52.7 77.1 76.1

104.5 80.1 120.0 102.9 98.4 76.1

Crl:CD(SD) Rats Page 61 of 66

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4

49

10 2

109 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

7 12 16 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

13 - 14 18 - 19 23

Females

13

1

10

19-20

25

1

10

32

5 NEUROMUSCULAR OBSERVATIONS

1

GRIPSTRENGTH - FORELIMB (g) 

735.3 779.3 627.5 MEAN

S.D.MINMAX

188.19 154.30 76.51

467.3 521.0 573.4904.7 999.3 681.6

542.6

0.00

542.6542.6

994.9

0.00

994.9994.9

2

GRIPSTRENGTH - HINDLIMB (g) 

527.8 481.7 406.7 MEAN

S.D.MINMAX

129.06 161.99 51.90

357.7 300.9 370.0671.6 717.3 443.4

429.2

0.00

429.2429.2

631.8

0.00

631.8631.8

3

ROTAROD PERFORMANCE (seconds)

104.6 84.9 104.3 MEAN

S.D.MINMAX

5.36 28.47 0.48

100.3 34.3 104.0112.3 111.6 104.6

69.80.0069.869.8

65.80.0065.865.8

Crl:CD(SD) Rats Page 62 of 66

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

5 NEUROMUSCULAR OBSERVATIONS

4

HINDLIMB FOOTSPLAY (mm) 

62.9 55.1 61.4 60.1 69.9 58.6 MEAN

S.D.MINMAX

8.28 7.21 10.47 12.43 14.00 0.0045.6 50.0 34.4 44.0 60.0 58.672.5 60.2 73.0 71.9 79.8 58.6

Crl:CD(SD) Rats Page 63 of 66

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4

49

10 2

109 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

7 12 16 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

13 - 14 18 - 19 23

Females

13

1

10

19-20

25

1

10

32

5 NEUROMUSCULAR OBSERVATIONS

4

HINDLIMB FOOTSPLAY (mm) 

67.9 57.2 59.1 MEAN

S.D.MINMAX

7.86 11.41 19.0956.4 40.5 45.674.1 73.1 72.6

56.40.0056.456.4

61.10.0061.161.1

Crl:CD(SD) Rats Page 64 of 66

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21 2

153 10

15 6

108 35

2 1

10 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

PRETEST 2 3 4 5 6 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

5 - 7 8 9 - 11 10 - 11 11 - 13 12

Females

6 PHYSIOLOGICAL OBSERVATIONS

1

CATALEPSY (seconds)

0.3 0.4 0.4 0.3 0.4 0.3 MEAN

S.D.MINMAX

0.11 0.20 0.14 0.12 0.18 0.00

0.2 0.3 0.2 0.2 0.2 0.30.6 0.6 0.7 0.5 0.5 0.3

2

BODY TEMPERATURE (oC)

38.2 38.8 39.0 38.6 39.0 38.8 MEAN

S.D.MINMAX

0.63 0.37 0.59 0.71 0.35 0.0036.9 38.6 38.0 37.3 38.8 38.839.3 39.1 40.6 39.1 39.3 38.8

3

BODY WEIGHT (g)

152.5 206.2 223.8 235.1 250.1 258.6 MEAN

S.D.MINMAX

15.70 6.84 11.12 8.76 5.71 0.00127.2 201.3 205.1 219.0 246.0 258.6175.0 211.0 241.2 245.0 254.1 258.6

Crl:CD(SD) Rats Page 65 of 66

Crl:CD(SD) Rat Subchronic FOB HC v.1.1

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
4

49

10 2

109 10 NUMBER OF ANIMALS TESTED

AGE RANGE OF ANIMALS TESTED

7 12 16 TIME POINT (STUDY WEEK)

NUMBER OF STUDIES

 Subchronic - Functional Observation Battery

 WIL Research Laboratories - Historical Control Data

13 - 14 18 - 19 23

Females

13

1

10

19-20

25

1

10

32

6 PHYSIOLOGICAL OBSERVATIONS

1

CATALEPSY (seconds)

0.3 0.4 0.4 MEAN

S.D.MINMAX

0.15 0.18 0.17

0.2 0.2 0.20.5 0.8 0.5

0.5

0.00

0.50.5

0.4

0.00

0.40.4

2

BODY TEMPERATURE (oC)

38.9 38.5 38.9 MEAN

S.D.MINMAX

0.63 0.73 0.7338.2 36.9 38.439.6 39.5 39.5

37.90.0037.937.9

37.00.0037.037.0

3

BODY WEIGHT (g)

255.0 285.3 287.8 MEAN

S.D.MINMAX

3.70 8.52 19.76

250.8 270.7 273.9259.3 297.4 301.8

299.2

0.00

299.2299.2

356.4

0.00

356.4356.4

Crl:CD(SD) Rats Page 66 of 66

Crl:CD(SD) Rat Subchronic FOB HC v.1.1

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION


	
 

	
 
     

 ! " #$%& '(

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: M RAT SUBCHRONIC CRL:CD(SD)

Page 1 of 10

PRETEST

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

12 1255 714 562 282 284 317 410 150 97 41 24 25 3415 747 AM

13 1275 827 469 230 148 61 315 158 79 27 21 1 3010 602 AM15 1308 605 373 173 150 68 405 101 77 23 18 10 2677 634 PM

26.915.6

3

12551308

111.1

64.1

3

605827

94.354.4

3

373562

54.831.6

3

173282

Mean

StDev

SEM

Count

Min

Max

78.145.1

3

148284

146.0

84.3

3

61

317

53.330.8

3

315410

31.017.9

3

101158

11.0

6.4

3

7797

9.15.3

3

2341

2.91.7

3

1824

12.2

7.0

31

25

1279 716 468 228 194 148 377 137 84 31 21 12

25th Quartile

75th Quartile

1265 660 421 202 149 64 360 126 78 143 19 61292 771 515 256 217 192 407 154 88 168 22 18

369.4213.3

3

30342677

317

28443213

76.244.0

3

661602747618690

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: M RAT SUBCHRONIC CRL:CD(SD)

Page 2 of 10

WEEK 1

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

12 1283 742 569 514 232 185 377 150 113 102 29 32 3524 802 AM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1283 742 569 514 232 185 377 150 113 102 29 32

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

3524

N/AN/AN/AN/A

1

802

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: M RAT SUBCHRONIC CRL:CD(SD)

Page 3 of 10

WEEK 3

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

12 1148 696 567 423 266 140 259 116 91 63 44 24 3240 598 AM

15 1308 749 471 315 240 127 285 148 85 51 39 20 3210 627 PM

113.1

80.0

2

11481308

38.126.9

2

696749

67.948.0

2

471567

76.754.2

2

315423

Mean

StDev

SEM

Count

Min

Max

18.513.1

2

240266

9.36.6

2

127140

18.012.7

2

259285

22.115.6

2

116148

4.02.8

2

8591

8.35.9

2

5163

3.52.5

2

3944

3.12.2

2

2024

1228 722 519 369 253 133 272 132 88 57 42 22

25th Quartile

75th Quartile

1188 709 495 342 246 130 265 124 86 136 41 211268 736 543 396 259 137 278 140 89 147 43 23

21.215.0

2

32253210

140

32173232

21.114.9

2

612598627605620

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: M RAT SUBCHRONIC CRL:CD(SD)

Page 4 of 10

WEEK 4

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

7 1298 911 716 662 630 353 271 171 109 126 87 50 4570 814 AM

13 1326 769 470 345 349 341 294 152 86 55 59 56 3600 702 AM

19.814.0

2

12981326

100.3

71.0

2

769911

174.0123.1

2

470716

224.3158.6

2

345662

Mean

StDev

SEM

Count

Min

Max

199.0140.7

2

349630

8.15.7

2

341353

16.411.6

2

271294

13.4

9.5

2

152171

15.811.2

2

86

109

50.735.9

2

55

126

20.114.2

2

5987

4.33.1

2

5056

1312 840 593 503 490 347 282 162 98 91 73 53

25th Quartile

75th Quartile

1305 804 532 424 419 344 277 157 92 155 66 511319 875 655 583 560 350 288 166 103 164 80 54

685.9485.0

2

40853600

353

38434328

79.356.1

2

758702814730786

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: M RAT SUBCHRONIC CRL:CD(SD)

Page 5 of 10

WEEK 7

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

12 1178 623 495 314 167 212 226 99 79 43 19 29 2989 495 AM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1178 623 495 314 167 212 226 99 79 43 19 29

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

2989

N/AN/AN/AN/A

1

495

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: M RAT SUBCHRONIC CRL:CD(SD)

Page 6 of 10

WEEK 10

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

8 1408 1110 796 533 327 284 295 206 144 77 43 39 4459 803 AM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1408 1110 796 533 327 284 295 206 144 77 43 39

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

4459

N/AN/AN/AN/A

1

803

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: M RAT SUBCHRONIC CRL:CD(SD)

Page 7 of 10

WEEK 11

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

8 1300 605 265 83 34 169 256 59 27 7 2 31 2456 382 AM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1300 605 265 83 34 169 256 59 27 7 2 31

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

2456

N/AN/AN/AN/A

1

382

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: M RAT SUBCHRONIC CRL:CD(SD)

Page 8 of 10

WEEK 12

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

12 1102 627 436 374 299 262 193 83 57 52 37 31 3101 452 AM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1102 627 436 374 299 262 193 83 57 52 37 31

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

3101

N/AN/AN/AN/A

1

452

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: M RAT SUBCHRONIC CRL:CD(SD)

Page 9 of 10

WEEK 25

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

11 899 704 384 195 163 166 134 76 29 9 9 11 5022 535 PM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

899 704 384 195 163 166 134 76 29 9 9 11

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

5022

N/AN/AN/AN/A

1

535

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: M RAT SUBCHRONIC CRL:CD(SD)

Page 10 of 10

WEEK 31

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

11 824 438 253 132 147 107 128 34 15 5 11 4 3800 397 PM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

824 438 253 132 147 107 128 34 15 5 11 4

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

3800

N/AN/AN/AN/A

1

397

N/AN/AN/AN/A

NA = Not applicable

Version 1.128-Oct-08

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: F RAT SUBCHRONIC CRL:CD(SD)

Page 1 of 10

PRETEST

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

12 1240 576 405 276 219 412 415 134 94 43 35 109 3127 831 AM

13 1619 743 357 203 186 313 494 167 86 44 32 76 3421 898 AM15 1317 763 359 131 87 133 483 199 56 15 2 1 2790 756 PM

200.4115.7

3

12401619

102.7

59.3

3

576763

26.715.4

3

357405

72.541.9

3

131276

Mean

StDev

SEM

Count

Min

Max

68.739.7

3

87

219

141.3

81.6

3

133412

42.624.6

3

415494

32.218.6

3

134199

20.311.7

3

5694

16.1

9.3

3

1544

18.010.4

32

35

55.331.9

31

109

1392 694 374 203 164 286 464 167 79 34 23 62

25th Quartile

75th Quartile

1279 660 358 167 137 223 449 151 71 103 17 391468 753 382 239 202 362 488 183 90 202 33 93

316.0182.4

3

31132790

412

29583274

71.041.0

3

828756898794865

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: F RAT SUBCHRONIC CRL:CD(SD)

Page 2 of 10

WEEK 1

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

12 1366 673 364 508 498 271 435 177 69 119 108 70 3680 978 AM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1366 673 364 508 498 271 435 177 69 119 108 70

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

3680

N/AN/AN/AN/A

1

978

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: F RAT SUBCHRONIC CRL:CD(SD)

Page 3 of 10

WEEK 3

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

12 1225 591 342 317 307 425 361 128 67 76 61 92 3207 784 AM

15 1470 826 514 306 267 478 467 220 131 71 55 106 3862 1050 PM

173.5122.6

2

12251470

166.5117.8

2

591826

121.9

86.2

2

342514

7.95.6

2

306317

Mean

StDev

SEM

Count

Min

Max

28.119.9

2

267307

37.626.6

2

425478

75.153.1

2

361467

64.945.9

2

128220

45.231.9

2

67

131

3.42.4

2

7176

4.02.9

2

5561

10.2

7.2

2

92

106

1348 708 428 311 287 452 414 174 99 73 58 99

25th Quartile

75th Quartile

1286 649 385 309 277 439 387 151 83 244 57 961409 767 471 314 297 465 440 197 115 278 59 103

463.4327.7

2

35353207

478

33713699

187.9132.9

2

784

1050

917851984

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: F RAT SUBCHRONIC CRL:CD(SD)

Page 4 of 10

WEEK 4

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

13 1586 741 287 374 217 322 455 157 45 85 39 64 3526 844 AM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1586 741 287 374 217 322 455 157 45 85 39 64

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

3526

N/AN/AN/AN/A

1

844

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: F RAT SUBCHRONIC CRL:CD(SD)

Page 5 of 10

WEEK 7

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

12 1179 586 346 528 354 203 326 100 68 112 58 37 3196 700 AM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1179 586 346 528 354 203 326 100 68 112 58 37

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

3196

N/AN/AN/AN/A

1

700

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: F RAT SUBCHRONIC CRL:CD(SD)

Page 6 of 10

WEEK 10

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

8 1438 860 617 486 381 349 357 197 131 91 84 71 4131 931 AM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1438 860 617 486 381 349 357 197 131 91 84 71

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

4131

N/AN/AN/AN/A

1

931

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: F RAT SUBCHRONIC CRL:CD(SD)

Page 7 of 10

WEEK 11

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

8 1204 520 192 169 276 279 308 83 22 34 66 54 2640 568 AM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1204 520 192 169 276 279 308 83 22 34 66 54

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

2640

N/AN/AN/AN/A

1

568

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: F RAT SUBCHRONIC CRL:CD(SD)

Page 8 of 10

WEEK 12

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

12 1156 561 315 356 264 200 310 107 67 72 52 42 2852 651 AM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1156 561 315 356 264 200 310 107 67 72 52 42

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

2852

N/AN/AN/AN/A

1

651

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: F RAT SUBCHRONIC CRL:CD(SD)

Page 9 of 10

WEEK 25

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

11 1326 837 354 186 147 93 366 173 51 28 27 8 5884 1309 PM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1326 837 354 186 147 93 366 173 51 28 27 8

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

5884

N/AN/AN/AN/A

1

1309

N/AN/AN/AN/A

NA = Not applicable

3DJHRI

COMPANY SANITIZED DOES NOT CONTAIN CONFIDENTIAL BUSINESS INFORMATION
Sex: Species: Strain:

WIL Research Laboratories - Historical Control Summary of Locomotor Activity

Kinder Scientific

Study Type: F RAT SUBCHRONIC CRL:CD(SD)

Page 10 of 10

WEEK 31

0-10 11-20 21-30 31-40

TOTAL

41-50 51-60 0-10 11-20 21-30 31-40

AMBULATORY

41-50 51-60 Minutes

HC Number

Cumulative Cumulative

Time

11 1379 658 399 211 187 187 383 121 54 36 33 25 6042 1302 PM

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

Mean

StDev

SEM

Count

Min

Max

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1

N/AN/A

1379 658 399 211 187 187 383 121 54 36 33 25

25th Quartile

75th Quartile

N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/AN/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

1

6042

N/AN/AN/AN/A

1

1302

N/AN/AN/AN/A

NA = Not applicable

Version 1.128-Oct-08

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