UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington,
D.C. 20549





FORM 10-Q



|x | QUARTERLY
        REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
        
        For
        the quarterly period ended June 30, 2012
|- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



OR



| ̈ | TRANSITION
        REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
        
        For
        the transition period from ____ to ____
|- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



Commission
file number 000-33393



Northwest
Biotherapeutics, Inc.

(Exact Name
of Registrant as Specified in its Charter)



|Delaware                                                           | 94-3306718                          
|------------------------------------------------------------------ | ------------------------------------
|(State or other Jurisdiction of Incorporation or
    Organization) | (I.R.S. Employer Identification No.)



|4800 Montgomery
    Lane, Suite 800      | 20814     
|---------------------------------------- | ----------
|Bethesda, Maryland 20814                 | (Zip Code)
|(Address of Principal Executive Offices) |           



(240) 497-9024

(Registrant’s
Telephone Number, Including Area Code)



Indicate
by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities
Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such
reports), and (2) has been subject to such filing requirements for the past 90 days. YesxNo  ̈



Indicate
by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive
Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T(§232.405 of this chapter) during the
preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes xNo
 ̈



Indicate
by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller
reporting company. See definitions of “large accelerated filer,” “accelerated filer” and “smaller
reporting company” in Rule 12b-2 of the Exchange Act.



|Large accelerated filero                          | Accelerated filero | Non-accelerated filero | Smaller reporting company x
|------------------------------------------------- | ------------------ | ---------------------- | ---------------------------
|(do not check
    if a smaller reporting company)



Indicate
by check mark whether the Registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act) Yes  ̈No x



As
of August10, 2012, the total number of shares of common stock, par value $0.001 per share, outstanding was 175,871,162.











TABLE OF
CONTENTS



|                                                                                                                                                                                                             | Page
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | ----
|PART
    I - FINANCIAL INFORMATION                                                                                                                                                                           |     
|                                                                                                                                                                                                             |     
|Item 1. Financial Statements                                                                                                                                                                                 |     
|                                                                                                                                                                                                             |     
|Condensed Consolidated
    Balance Sheets as of June 30, 2012 and December 31, 2011(unaudited)                                                                                                               | 3   
|                                                                                                                                                                                                             |     
|Condensed Consolidated
    Statements of Operations (unaudited) for the three months and six months ended June 30, 2012 and 2011 and the period from
    March 18, 1996 (inception) to June 30, 2012         | 4   
|                                                                                                                                                                                                             |     
|Condensed Consolidated
    Statements of Comprehensive Loss (unaudited) for the three months and six months ended June 30, 2012 and 2011 and the period
    from March 18, 1996 (inception) to June 30, 2012 | 5   
|                                                                                                                                                                                                             |     
|Condensed Consolidated
    Statements of Changes in Stockholders’ Equity (Deficit) (unaudited) for the six months ended June 30, 2012                                                                        | 6   
|                                                                                                                                                                                                             |     
|Condensed Consolidated
    Statements of Cash Flows (unaudited) for the six months ended June 30, 2012 and 2011 and the period from March 18, 1996 (inception)
    to June 30, 2012                          | 7   
|                                                                                                                                                                                                             |     
|Notes to Condensed Consolidated
    Financial Statements                                                                                                                                                     | 9   
|                                                                                                                                                                                                             |     
|Item 2. Management’s
    Discussion and Analysis of Financial Condition and Results of Operations                                                                                                            | 17  
|                                                                                                                                                                                                             |     
|Item 4. Controls and
    Procedures                                                                                                                                                                          | 20  
|                                                                                                                                                                                                             |     
|PART
    II - OTHER INFORMATION                                                                                                                                                                              |     
|                                                                                                                                                                                                             |     
|Item 1. Legal Proceedings                                                                                                                                                                                    | 21  
|                                                                                                                                                                                                             |     
|Item
        2. Unregistered Sales of Equity Securities and Use of Proceeds                                                                                                                                  | 21  
|                                                                                                                                                                                                             |     
|Item
5. Other Information                                                                                                                                                                                    | 21  
|                                                                                                                                                                                                             |     
|Item 6. Exhibits                                                                                                                                                                                             | 22  
|                                                                                                                                                                                                             |     
|SIGNATURES                                                                                                                                                                                                   | 23  



2







Part I -
Financial Information



NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



CONDENSED
CONSOLIDATED BALANCE SHEETS

(in thousands)



|                                                                                                                                                                                                           |  | June 30,  |          |   |              |  
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | --------- | -------- | - | ------------ | -
|                                                                                                                                                                                                           |  | 2012      |          |   | December 31, |  
|                                                                                                                                                                                                           |  | Unaudited |          |   | 2011         |  
|                                                                                                                                                                                                           |  |           |          |   |              |  
|ASSETS                                                                                                                                                                                                     |  |           |          |   |              |  
|Current assets:                                                                                                                                                                                            |  |           |          |   |              |  
|Cash and cash equivalents                                                                                                                                                                                  |  | $         | 430      |   |              | $
|Accounts receivable                                                                                                                                                                                        |  |           | 195      |   |              |  
|Prepaid expenses and other current assets                                                                                                                                                                  |  |           | 260      |   |              |  
|Total current assets                                                                                                                                                                                       |  |           | 885      |   |              |  
|Property and equipment:                                                                                                                                                                                    |  |           |          |   |              |  
|Laboratory equipment                                                                                                                                                                                       |  |           | 56       |   |              |  
|Office furniture and other equipment                                                                                                                                                                       |  |           | 172      |   |              |  
|                                                                                                                                                                                                           |  |           | 228      |   |              |  
|Less accumulated depreciation and amortization                                                                                                                                                             |  |           | (128     | ) |              |  
|Property and equipment, net                                                                                                                                                                                |  |           | 100      |   |              |  
|Deposit and other non-current assets                                                                                                                                                                       |  |           | 33       |   |              |  
|Total assets                                                                                                                                                                                               |  | $         | 1,018    |   |              | $
|                                                                                                                                                                                                           |  |           |          |   |              |  
|LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)                                                                                                                                                             |  |           |          |   |              |  
|Current liabilities:                                                                                                                                                                                       |  |           |          |   |              |  
|Accounts payable (includes related party of $3,785 and $1,589 in 2012 and 2011, respectively)                                                                                                              |  | $         | 6,895    |   |              | $
|Accrued expenses (includes related party of $1,051 and $630 in 2012 and 2011, respectively)                                                                                                                |  |           | 4,437    |   |              |  
|Notes payable (includes related party of $2,077 and $2,056 in 2012 and 2011, respectively)                                                                                                                 |  |           | 5,461    |   |              |  
|Convertible notes, net (includes related party of $5,708 and $3,588 in 2012 and 2011, respectively)                                                                                                        |  |           | 13,487   |   |              |  
|Embedded derivative liability                                                                                                                                                                              |  |           | 53       |   |              |  
|Liability for reclassified equity contracts                                                                                                                                                                |  |           | -        |   |              |  
|Total current liabilities                                                                                                                                                                                  |  |           | 30,333   |   |              |  
|Long term liabilities:                                                                                                                                                                                     |  |           |          |   |              |  
|Notes payable                                                                                                                                                                                              |  |           | 200      |   |              |  
|Convertible notes payable, net                                                                                                                                                                             |  |           | 1,143    |   |              |  
|Total long term liabilities                                                                                                                                                                                |  |           | 1,343    |   |              |  
|Total liabilities                                                                                                                                                                                          |  |           | 31,676   |   |              |  
|Stockholders’ equity (deficit):                                                                                                                                                                            |  |           |          |   |              |  
|Preferred stock, $0.001 par value; 20,000,000 shares authorized and none issued and outstanding                                                                                                            |  |           |          |   |              |  
|Common stock, $0.001 par value; 450,000,000 and 150,000,000
    shares authorized, and 165,362,987 and 149,345,623 shares issued and outstanding at June 30, 2012  and December 31,
    2011, respectively |  |           | 165      |   |              |  
|Additional paid-in capital                                                                                                                                                                                 |  |           | 241,446  |   |              |  
|Deficit accumulated during the development stage                                                                                                                                                           |  |           | (272,079 | ) |              |  
|Cumulative translation adjustment                                                                                                                                                                          |  |           | (190     | ) |              |  
|Total stockholders’ equity (deficit)                                                                                                                                                                       |  |           | (30,658  | ) |              |  
|Total liabilities and stockholders’ equity (deficit)                                                                                                                                                       |  | $         | 1,018    |   |              | $



See accompanying
notes to the condensed consolidated financial statements



3







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



CONDENSED
CONSOLIDATED STATEMENTS OF OPERATIONS

(in thousands,
except per share data)

(Unaudited)



|                                                                                                               |  | Three Months Ended |         |   | Six Months Ended |   |         | Period from March    | 
|-------------------------------------------------------------------------------------------------------------- |  | ------------------ | ------- | - | ---------------- | - | ------- | -------------------- | 
|                                                                                                               |  | June 30,           |         |   | June 30,         |   |         | 18, 1996 (Inception) | 
|                                                                                                               |  | 2012               |         |   | 2011             |   |         | 2012                 | 
|                                                                                                               |  |                    |         |   |                  |   |         |                      | 
|Revenues:                                                                                                      |  |                    |         |   |                  |   |         |                      | 
|Research material sales                                                                                        |  | $                  | -       |   |                  | $ | -       |                      | 
|Contract research and development from related parties                                                         |  |                    | -       |   |                  |   | -       |                      | 
|Research grants and other                                                                                      |  |                    | 330     |   |                  |   | -       |                      | 
|Total revenues                                                                                                 |  |                    | 330     |   |                  |   | -       |                      | 
|Operating cost and expenses:                                                                                   |  |                    |         |   |                  |   |         |                      | 
|Cost of research material sales                                                                                |  |                    | -       |   |                  |   | -       |                      | 
|Research and development                                                                                       |  |                    | 7,040   |   |                  |   | 3,469   |                      | 
|General and administration                                                                                     |  |                    | 2,025   |   |                  |   | 5,555   |                      | 
|Depreciation and amortization                                                                                  |  |                    | 2       |   |                  |   | 4       |                      | 
|Loss on facility sublease                                                                                      |  |                    | -       |   |                  |   | -       |                      | 
|Asset impairment loss and other (gain) loss                                                                    |  |                    | -       |   |                  |   | -       |                      | 
|Total operating costs and expenses                                                                             |  |                    | 9,067   |   |                  |   | 9,028   |                      | 
|Loss from operations                                                                                           |  |                    | (8,737  | ) |                  |   | (9,028  | )                    | 
|Other income (expense):                                                                                        |  |                    |         |   |                  |   |         |                      | 
|Valuation of reclassified equity instruments                                                                   |  |                    | -       |   |                  |   | (1,462  | )                    | 
|Conversion inducement expense                                                                                  |  |                    | -       |   |                  |   | (125    | )                    | 
|Derivative valuation gain/(loss)                                                                               |  |                    | 200     |   |                  |   | (148    | )                    | 
|Gain on sale of intellectual property and property and equipment                                               |  |                    | -       |   |                  |   | -       |                      | 
|Interest expense                                                                                               |  |                    | (1,613  | ) |                  |   | (1,565  | )                    | 
|Interest income and other                                                                                      |  |                    | -       |   |                  |   | -       |                      | 
|Net loss                                                                                                       |  |                    | (10,150 | ) |                  |   | (12,328 | )                    | 
|Issuance of common stock in connection with elimination of Series A and Series A-1 preferred stock preferences |  |                    | -       |   |                  |   | -       |                      | 
|Modification of Series A preferred stock warrants                                                              |  |                    | -       |   |                  |   | -       |                      | 
|Modification of Series A-1 preferred stock warrants                                                            |  |                    | -       |   |                  |   | -       |                      | 
|Series A preferred stock dividends                                                                             |  |                    | -       |   |                  |   | -       |                      | 
|Series A-1 preferred stock dividends                                                                           |  |                    | -       |   |                  |   | -       |                      | 
|Warrants issued on Series A and Series A-1 preferred stock dividends                                           |  |                    | -       |   |                  |   | -       |                      | 
|Accretion of Series A preferred stock mandatory redemption obligation                                          |  |                    | -       |   |                  |   | -       |                      | 
|Series A preferred stock redemption fee                                                                        |  |                    | -       |   |                  |   | -       |                      | 
|Beneficial conversion feature of Series D preferred stock                                                      |  |                    | -       |   |                  |   | -       |                      | 
|Net loss applicable to common stockholders                                                                     |  | $                  | (10,150 | ) |                  | $ | (12,328 | )                    | 
|Net loss per share applicable to common stockholders - basic and diluted                                       |  | $                  | (0.06   | ) |                  | $ | (0.15   | )                    | 
|Weighted average shares used in computing basic and diluted loss per share                                     |  |                    | 162,357 |   |                  |   | 83,890  |                      | 



See accompanying
notes to the condensed consolidated financial statements



4







NORTHWEST
BIOTHERAPEUTICS, INC.

(A
Development Stage Company)



CONDENSED
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

(in
thousands)

(Unaudited)



|                                        |  |                    |         |   |                  |   |         |                |  |   |         |   |  | Period from   |        
|--------------------------------------- |  | ------------------ | ------- | - | ---------------- | - | ------- | -------------- |  | - | ------- | - |  | ------------- | -------
|                                        |  | Three Months Ended |         |   | Six Months Ended |   |         | March 18, 1996 | 
|                                        |  | June 30,           |         |   | June 30,         |   |         | (Inception) to | 
|                                        |  | 2012               |         |   | 2011             |   |         | 2012           |  |   | 2011    |   |  | June 30, 2012 |        
|                                        |  |                    |         |   |                  |   |         |                |  |   |         |   |  |               |        
|Net loss                                |  | $                  | (10,150 | ) |                  | $ | (12,328 | )              |  | $ | (20,301 | ) |  | $             | (20,736
|Other comprehensive loss                |  |                    |         |   |                  |   |         |                |  |   |         |   |  |               |        
|Foreign currency translation adjustment |  |                    | -       |   |                  |   | (103    | )              |  |   | (40     | ) |  |               | (123   
|Total comprehensive loss                |  | $                  | (10,150 | ) |                  | $ | (12,431 | )              |  | $ | (20,341 | ) |  | $             | (20,859



See
accompanying notes to the condensed consolidated financial statements



5







NORTHWEST
BIOTHERAPEUTICS, INC.

(A
Development Stage Company)



CONDENSED
CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS’ EQUITY (DEFICIT)

(in
thousands)

(Unaudited)



|                                                                      |  | Six Months |         
|--------------------------------------------------------------------- |  | ---------- | --------
|                                                                      |  | Ended      |         
|                                                                      |  | June 30,   |         
|                                                                      |  | 2012       |         
|                                                                      |  |            |         
|Common stock:                                                         |  |            |         
|Balance, beginning of the period                                      |  | $          | 150     
|Notes payable conversions / stock
    issuances for cash and services |  |            | 11      
|Balance, end of the period                                            |  | $          | 165     
|                                                                      |  |            |         
|Additional paid-in-capital:                                           |  |            |         
|Balance, beginning of the period                                      |  | $          | 199,605 
|Stock issuances for cash                                              |  |            | 347     
|Notes payable conversions                                             |  |            | 4,647   
|Modifications / reclassifications of equity instruments               |  |            | 29,412  
|Stock based compensation                                              |  |            | 1,897   
|Debt disounts/beneficial conversion features of securities            |  |            | 5,520   
|Stock issuance for services                                           |  |            | 18      
|Balance, end of the period                                            |  | $          | 241,446 
|                                                                      |  |            |         
|Deficit accumulated during development stage:                         |  |            |         
|Balance, beginning of the period                                      |  | $          | (251,778
|Net loss                                                              |  |            | (20,301 
|Balance, end of the period                                            |  | $          | (272,079
|                                                                      |  |            |         
|Cumulative translation adjustment:                                    |  |            |         
|Balance, beginning of the period                                      |  | $          | (150    
|Foreign currency translation adjustment                               |  |            | (40     
|Balance, end of the period                                            |  | $          | (190    
|                                                                      |  |            |         
|Total stockholders’ equity (deficit)                                  |  | $          | (30,658 



See accompanying
notes to the condensed consolidated financial statements



6







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



CONDENSED
CONSOLIDATED STATEMENTS OF CASH FLOWS

(in thousands)

(Unaudited)



|                                                                                          |  |                  |         |   |                |   |         | Period from   | 
|----------------------------------------------------------------------------------------- |  | ---------------- | ------- | - | -------------- | - | ------- | ------------- | 
|                                                                                          |  | Six Months Ended |         |   | March 18, 1996 |  
|                                                                                          |  | June 30,         |         |   | (Inception) to |  
|                                                                                          |  | 2012             |         |   | 2011           |   |         | June 30, 2012 | 
|Cash Flows from Operating Activities:                                                     |  |                  |         |   |                |   |         |               | 
|Net Loss                                                                                  |  | $                | (20,301 | ) |                | $ | (20,736 | )             | 
|Reconciliation of net loss to net cash used in operating activities:                      |  |                  |         |   |                |   |         |               | 
|Depreciation and amortization                                                             |  |                  | 4       |   |                |   | 4       |               | 
|Amortization of deferred financing costs                                                  |  |                  | -       |   |                |   | -       |               | 
|Amortization debt discount                                                                |  |                  | 6,016   |   |                |   | 2,163   |               | 
|Derivative valuation (gain) loss                                                          |  |                  | (548    | ) |                |   | 309     |               | 
|Accrued interest converted to stock                                                       |  |                  | -       |   |                |   | -       |               | 
|Accreted interest on convertible promissory note                                          |  |                  | -       |   |                |   | -       |               | 
|Stock-based compensation costs                                                            |  |                  | 1,897   |   |                |   | 5,951   |               | 
|Stock and warrants issued for services and other expenses                                 |  |                  | -       |   |                |   | 3,470   |               | 
|Loan conversion inducement                                                                |  |                  | -       |   |                |   | 125     |               | 
|Valuation of reclassified equity contracts                                                |  |                  | (491    | ) |                |   | 1,462   |               | 
|Asset impairment loss and loss (gain) on sale of properties                               |  |                  | -       |   |                |   | -       |               | 
|Loss on facility sublease                                                                 |  |                  | -       |   |                |   | -       |               | 
|Increase (decrease) in cash resulting from changes in assets and liabilities:             |  |                  |         |   |                |   |         |               | 
|Accounts receivable                                                                       |  |                  | (195    | ) |                |   | -       |               | 
|Prepaid expenses and other current assets                                                 |  |                  | (166    | ) |                |   | 17      |               | 
|Accounts payable and accrued expenses                                                     |  |                  | 5,427   |   |                |   | 2,194   |               | 
|Deposits and other non-current assets                                                     |  |                  | (17     | ) |                |   | -       |               | 
|Accrued loss on sublease                                                                  |  |                  | -       |   |                |   | -       |               | 
|Deferred rent                                                                             |  |                  | -       |   |                |   | -       |               | 
|Net Cash used in Operating Activities                                                     |  |                  | (8,374  | ) |                |   | (5,041  | )             | 
|Cash Flows from Investing Activities:                                                     |  |                  |         |   |                |   |         |               | 
|Purchase of property and equipment, net                                                   |  |                  | (27     | ) |                |   | (3      | )             | 
|Proceeds from sale of property and equipment                                              |  |                  | -       |   |                |   | -       |               | 
|Proceeds from sale of intellectual property                                               |  |                  | -       |   |                |   | -       |               | 
|Proceeds from sale of marketable securities                                               |  |                  | -       |   |                |   | -       |               | 
|Refund of security deposit                                                                |  |                  | -       |   |                |   | -       |               | 
|Transfer of restricted cash                                                               |  |                  | -       |   |                |   | -       |               | 
|Net Cash used in Investing Activities                                                     |  |                  | (27     | ) |                |   | (3      | )             | 
|Cash Flows from Financing Activities:                                                     |  |                  |         |   |                |   |         |               | 
|Proceeds from issuance of notes payable                                                   |  |                  | -       |   |                |   | 6,222   |               | 
|Proceeds from issuance of convertible notes payable                                       |  |                  | 8,500   |   |                |   | 500     |               | 
|Repayment of note payable to related parties                                              |  |                  | -       |   |                |   | -       |               | 
|Proceeds from issuance of convertible promissory note and warrants, net of issuance costs |  |                  | -       |   |                |   | -       |               | 
|Repayment of convertible promissory note                                                  |  |                  | -       |   |                |   | (350    | )             | 
|Borrowing under line of credit, Northwest Hospital                                        |  |                  | -       |   |                |   | -       |               | 
|Repayment of line of credit, Northwest Hospital                                           |  |                  | -       |   |                |   | -       |               | 
|Payment on capital lease obligations                                                      |  |                  | -       |   |                |   | -       |               | 
|Payments on note payable                                                                  |  |                  | -       |   |                |   | -       |               | 
|Proceeds from issuance preferred stock, net                                               |  |                  | -       |   |                |   | -       |               | 
|Proceeds from exercise of stock options and warrants                                      |  |                  | -       |   |                |   | -       |               | 
|Proceeds from issuance common stock, net                                                  |  |                  | 347     |   |                |   | 5,340   |               | 
|Proceeds from sale of stock warrant                                                       |  |                  | -       |   |                |   | 4       |               | 
|Payment of preferred stock dividends                                                      |  |                  | -       |   |                |   | -       |               | 
|Series A preferred stock redemption fee                                                   |  |                  | -       |   |                |   | -       |               | 
|Deferred financing costs                                                                  |  |                  | -       |   |                |   | -       |               | 
|Net Cash provided by Financing Activities                                                 |  |                  | 8,847   |   |                |   | 11,716  |               | 
|Effect of exchange rates on cash and cash equivalents                                     |  |                  | (40     | ) |                |   | (123    | )             | 
|Net increase (decrease) in cash and cash equivalents                                      |  |                  | 406     |   |                |   | 6,549   |               | 
|Cash and cash equivalents at beginning of period                                          |  |                  | 24      |   |                |   | 153     |               | 
|Cash and cash equivalent at end of period                                                 |  | $                | 430     |   |                | $ | 6,702   |               | 



See accompanying
notes to the condensed consolidated financial statements



7







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



CONDENSED
CONSOLIDATED STATEMENTS OF CASH FLOWS

(in thousands)

(Unaudited)



|                                                                                              |  |                  |        |  |                |   |       | Period from   | 
|--------------------------------------------------------------------------------------------- |  | ---------------- | ------ |  | -------------- | - | ----- | ------------- | 
|                                                                                              |  | Six Months Ended |        |  | March 18, 1996 |  
|                                                                                              |  | June 30,         |        |  | (Inception) to |  
|                                                                                              |  | 2012             |        |  | 2011           |   |       | June 30, 2012 | 
|                                                                                              |  |                  |        |  |                |   |       |               | 
|Supplemental disclosure of cash flow information - Cash paid during the period for interest   |  | $                | -      |  |                | $ | -     |               | 
|Supplemental schedule of non-cash financing activities:                                       |  |                  |        |  |                |   |       |               | 
|Equipment acquired through capital leases                                                     |  | $                | -      |  |                | $ | -     |               | 
|Issuance of common stock in connection with elimination of Series A and                       |  |                  |        |  |                |   |       |               | 
|Series A-1 preferred stock preferences                                                        |  |                  | -      |  |                |   | -     |               | 
|Issuance of common stock in connection with conversion of liabilities                         |  |                  | 4,658  |  |                |   | 1,920 |               | 
|Modification of Series A preferred stock warrants                                             |  |                  | -      |  |                |   | -     |               | 
|Modification of Series A-1 preferred stock warrants                                           |  |                  | -      |  |                |   | -     |               | 
|Warrants issued on Series A and Series A-1 preferred stock dividends                          |  |                  | -      |  |                |   | -     |               | 
|Liability for reclassified equity contracts                                                   |  |                  | 29,412 |  |                |   | -     |               | 
|Accretion of mandatorily redeemable Series A preferred stock redemption obligation            |  |                  | -      |  |                |   | -     |               | 
|Debt discount on promissory notes                                                             |  |                  | 5,520  |  |                |   | 4,862 |               | 
|Conversion of convertible promissory notes and accrued interest to Series D preferred stock   |  |                  | -      |  |                |   | -     |               | 
|Conversion of convertible promissory notes and accrued interest to Series A-1 preferred stock |  |                  | -      |  |                |   | -     |               | 
|Conversion of convertible promissory notes and accrued interest to common stock               |  |                  | -      |  |                |   | -     |               | 
|Issuance of Series C preferred stock warrants in connection with lease agreement              |  |                  | -      |  |                |   | -     |               | 
|Issuance of common stock or notes to settle accounts payable                                  |  |                  | 734    |  |                |   | -     |               | 
|Liability for and issuance of common stock and warrants to Medarex                            |  |                  | -      |  |                |   | -     |               | 
|Issuance of common stock to landlord                                                          |  |                  | -      |  |                |   | -     |               | 
|Deferred compensation on issuance of stock options and restricted stock grants                |  |                  | -      |  |                |   | -     |               | 
|Cancellation of options and restricted stock                                                  |  |                  | -      |  |                |   | -     |               | 
|Financing of prepaid insurance through note payable                                           |  |                  | -      |  |                |   | -     |               | 
|Stock subscription receivable                                                                 |  |                  | -      |  |                |   | -     |               | 



See accompanying
notes to the condensed consolidated financial statements



8







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



1. Basis of Presentation



The
accompanying unaudited condensed consolidated financial statements include the accounts of Northwest Biotherapeutics, Inc. and
its subsidiaries, NW Bio Europe Sarl and NW Bio GmBh (collectively, the “Company”, “we”, “us”,
and “our”). All material intercompany balances and transactions have been eliminated. The accompanying unaudited condensed
consolidated financial statements should be read in conjunction with the financial statements included in our Annual Report on
Form 10-K for the year ended December 31, 2011. The year-end condensed balance sheet data was derived from audited financial statements,
but does not include all disclosures required by accounting principles generally accepted in the United States of America (“GAAP”).
All normal recurring adjustments which are necessary for the fair presentation of the results for the interim periods are reflected
herein. Operating results for the three month and six month periods ended June 30, 2011 and 2012 are not necessarily indicative
of results to be expected for a full year.



The
independent registered public accounting firm’s report on the financial statements for the fiscal year ended December 31,
2011 states that because of recurring operating losses, net operating cash flow deficits, and a deficit accumulated during the
development stage, there is substantial doubt about the Company’s ability to continue as a going concern. A “going
concern” opinion indicates that the financial statements have been prepared assuming the Company will continue as a going
concern and do not include any adjustments to reflect the possible future effects on the recoverability and classification of
assets or the amounts and classification of liabilities that may result from the outcome of this uncertainty.



2. Summary of Significant Accounting
Policies



The Company
implemented the following accounting policies during the period ended June 30, 2012.



Revenue
recognition. In various situations, the Company receives certain cost payments from patients. These are generally non-refundable,
and are not dependent on the Company’s ongoing future performance. The Company has adopted a policy of recognizing these
payments as revenue when received.



Accounts Receivable. Accounts
receivable balance includes balances due from research grants and other services. We record an allowance for doubtful accounts
for our best estimate of the amount of probable credit losses in our existing accounts receivable. We determine the allowance
for doubtful accounts based primarily on historical write-off experience. Account balances that are deemed uncollectible, are
charged off against the allowance after all means of collection have been exhausted and the potential for recovery is considered
remote. No allowance was necessary for the periods presented.



In June 2011,
the Financial Accounting Standards Board issued ASU No. 2011-05, Comprehensive Income, or ASU 2011-05. The guidance in ASU 2011-05
revises the manner in which entities present comprehensive income in their financial statements. An entity is required to report
the components of comprehensive income in either one or two consecutive financial statements:



|· | A single, continuous statement must present the components of net income
    and total net income, the components of other comprehensive income and total other comprehensive income, and a total for comprehensive
    income; or
|- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|· | In a two-statement approach, an entity must present the components of net
    income and total net income in the first statement. That statement must be immediately followed by a financial statement that
    presents the components of other comprehensive income, a total for other comprehensive income, and a total for comprehensive
    income.
|- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



ASU 2011-05
does not change the items that must be reported in other comprehensive income. The amendments in ASU 2011-05 are effective for
fiscal years beginning after December 15, 2011. The Company adopted this guidance, and implemented the two-statement approach.



The
other significant accounting policies used in the preparation of the Company’s condensed consolidated financial statements
are disclosed in Note 3 to our consolidated financial statements included in our Annual Report on Form 10-K for the year ended
December 31, 2011.



3. Stock-Based Compensation



Compensation
expense for all stock-based awards is measured at the grant date based on the fair value of the award and is recognized as an
expense, on a straight-line basis, over the employee's requisite service period (generally the vesting period of the equity award).
The fair value of each option award is estimated on the date of grant using a Black-Scholes option valuation model. Stock-based
compensation expense is recognized only for those awards that are expected to vest using an estimated forfeiture rate. We estimate
pre-vesting option forfeitures at the time of grant and reflect the impact of estimated pre-vesting option forfeitures in compensation
expense recognized. For options and warrants issued to non-employees, the Company recognizes stock compensation costs utilizing
the fair value methodology over the related period of benefit.







9







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



A
summary of stock options activity for 2012 is as follows (shares in thousands):



|                                 |  |         |        |  |          |   |      | Weighted |  |   | Weighted    |  |  |           |          
|-------------------------------- |  | ------- | ------ |  | -------- | - | ---- | -------- |  | - | ----------- |  |  | --------- | ---------
|                                 |  |         |        |  | Weighted |   |      | Average  |  |   | Average     |  |  |           |          
|                                 |  | Number  |        |  | Average  |   |      | Grant    |  |   | Remaining   |  |  | Aggregate |          
|                                 |  | of      |        |  | Exercise |   |      | Date     |  |   | Contractual |  |  | Intrinsic |          
|                                 |  | Options |        |  | Price    |   |      | Fair     |  |   | Life        |  |  | Value     |          
|                                 |  |         |        |  |          |   |      |          |  |   |             |  |  |           |          
|Outstanding at December 31, 2011 |  |         | 24,822 |  |          | $ | 0.66 |          |  | $ | 0.66        |  |  |           |          
|2012 activity                    |  |         | -      |  |          |   | -    |          |  |   | -           |  |  |           |          
|Outstanding at June 30, 2012     |  |         | 24,822 |  |          | $ | 0.66 |          |  | $ | 0.66        |  |  |           | 6.1 years
|Exercisable at June 30, 2012     |  |         | 10,794 |  |          | $ | 0.66 |          |  | $ | 0.66        |  |  |           | 8.5 years



Stock-based
compensation expense was as follows for the three months and six months ended June 30, 2012 and 2011 (in thousands):



|                                        |  | Three Months Ended |     |  | Six Months Ended |  
|--------------------------------------- |  | ------------------ | --- |  | ---------------- | -
|                                        |  | June 30,           |     |  | June 30,         |  
|                                        |  | 2012               |     |  | 2011             |  
|                                        |  |                    |     |  |                  |  
|Research and development                |  | $                  | 131 |  |                  | $
|General and administrative              |  |                    | 724 |  |                  |  
|Total stock- based compensation expense |  | $                  | 855 |  |                  | $



There were
no options to purchase common stock granted during the three month and six month periods ended June 30, 2012. At June 30, 2012,
the unrecognized compensation expense related to stock options was $2.7 million which is to be recognized over a weighted average
period of approximately 3 years.



4. Fair Value Measurements



Fair value
is defined as the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between
market participants at the measurement date. U.S. GAAP establishes a three tier fair value hierarchy which prioritizes the inputs
used in measuring fair value. The hierarchy gives the highest priority to unadjusted quoted prices in active markets for identical
assets or liabilities (Level 1 measurements) and the lowest priority to unobservable inputs (Level 3 measurements). These tiers
include:



| | · | Level 1, defined as observable inputs such as quoted prices for identical
    instruments in active markets;
| | - | ------------------------------------------------------------------------------------------------------------



| | · | Level 2, defined as inputs other than quoted prices in active markets that
    are either directly or indirectly observable such as quoted prices for similar instruments in active markets or quoted prices
    for identical or similar instruments in markets that are not active; and
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | Level 3, defined as unobservable inputs in which little or no market data
    exists, therefore requiring an entity to develop its own assumptions, such as valuations derived from valuation techniques
    in which one or more significant inputs or significant value drivers are unobservable.
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The Company's
liability for reclassified equity contracts was measured using significant unobservable (Level 3) inputs.



As a result
of the Company entering into convertible promissory notes and issuing warrants to purchase common stock, the Company's total potential
outstanding common stock exceeded the Company’s authorized shares by approximately 109 million shares as of December 31,
2011, as also discussed in Note 7. As a result, the Company was required to value a number of shares equal to the excess issuable
on exercise of warrants and options and on conversion of convertible notes and recognize the value as a liability. The Company’s
stockholders approved an increase in the number of authorized shares sufficient to cover the excess as of February 6, 2012. At
that time, the liability was re-measured, with changes in value included in other income/(expense), and then reclassified to additional
paid-in capital (thereby removing it from the Company’s liabilities).



10







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



The following
table represents the activity for the Company’s liability for reclassified equity contracts for the three month and six
month periods ended June 30, 2012 and 2011:



|                                            |  | Three Months Ended |   |  | Six Months Ended |  
|------------------------------------------- |  | ------------------ | - |  | ---------------- | -
|                                            |  | June 30,           |   |  | June 30,         |  
|                                            |  | 2012               |   |  | 2011             |  
|                                            |  |                    |   |  |                  |  
|Beginning balance                           |  | $                  | - |  |                  | $
|Liabilities reclassified                    |  |                    | - |  |                  |  
|Change in value of reclassified liabilities |  |                    | - |  |                  |  
|Liabilities reclassified to equity          |  |                    | - |  |                  |  
|Ending balance                              |  | $                  | - |  |                  | $



The
Company concluded that certain conversion features and warrant agreements included down-round provisions and were not
indexed to the Company’s stock (and are therefore recorded as derivative liabilities). The Company recognizes the
derivative liabilities at their respective fair values using a binomial model adjusted for the probability of issuance using
a Monte Carlo simulation. Changes in the fair value are recorded in “Derivative valuation gain (loss)” in the
condensed consolidated statements of operations. Key assumptions for determining fair values during the periods presented
included expected terms ranging from between 3  and 15 months, volatility ranging from between 95% and 190% and risk-free
interest rate of 0.18%.



The
Company's embedded derivative liability was measured using significant unobservable (Level 3) inputs. The following table represents
the Company’s embedded derivative liability activity for the three months and six months ended June 30, 2012 and 2011:



|                                                                                      |  | Three Months Ended |          |   | Six Months Ended |  
|------------------------------------------------------------------------------------- |  | ------------------ | -------- | - | ---------------- | -
|                                                                                      |  | June 30,           |          |   | June 30,         |  
|                                                                                      |  | 2012               |          |   | 2011             |  
|                                                                                      |  |                    |          |   |                  |  
|Beginning balance                                                                     |  | $                  | 253,000  |   |                  | $
|Reclassification to stockholders' equity upon conversion and expiration of derivative |  |                    | -        |   |                  |  
|Embedded derivative liability recognized                                              |  |                    | -        |   |                  |  
|Net change in fair value of embedded derivative liabilities                           |  |                    | (200,000 | ) |                  |  
|Ending balance                                                                        |  | $                  | 53,000   |   |                  | $



5. Liquidity
and Going Concern



The Company
has experienced recurring losses from operations, and, as of June 30, 2012, had a working capital deficit of $29.4 million and
a deficit accumulated during the development stage of $272.1million, and has used $125.6 million for operating cash flows.



Since
2004, Toucan Capital Fund II, L.P. (“Toucan Capital”), Toucan Partners LLC (“Toucan Partners”), entities
controlled by Ms. Linda Powers, the managing director of Toucan Capital and managing member of Toucan Partners, and Ms. Linda
Powers (collectively “Toucan”) have provided substantial funding to the Company. During the period from 2004 to 2007,
the funding consisted of various loans and the purchase of common stock. Under a Conversion Agreement during 2007, all loans payable
to Toucan outstanding at the time were converted to preferred stock and the preferred stock was subsequently converted to common
stock. As a result of additional loans, as of June 30, 2012, notes payable include $4.3 million convertible notes payable to Toucan.
The notes payable to Toucan outstanding as of June 30, 2012, are convertible at prices ranging from $0.20 to $0.57.



In
addition, the Company utilizes the services of Cognate BioServices, Inc., an entity controlled by Toucan, for manufacturing
DCVax product candidates, regulatory advice, research and development preclinical activities, and managing clinical trials.
Accounts payable to Cognate BioServices, Inc. amounted to $3.3 million as of June 30, 2012.



11







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



The Company received
proceeds of $0.7 million in 2011 on an operational loan basis, from Artecel, Inc. Repayment terms as well as warrant coverage were
agreed to in August 2012. The Note now carries original issue discount of ten percent, an interest rate of ten percent, and a
six-month maturity. The loan is convertible at 90% of the average of the lowest five days’ closing prices of the Company’s
common stock in the twenty trading days prior to conversion. The loan carries one hundred percent warrant coverage, with an exercise
price of $0.40, and an exercise period of five years. The Company and Artecel have entered into three extensions of this note.
In consideration of the extensions, the Company agreed to issue warrants to Artecel on the same basis as the warrants issued to
unrelated angel investors for note extensions.



As
of June 30, 2012, Toucan held 71,202,148 shares of common stock, representing approximately 43% of the common stock outstanding.
Further, as of June 30, 2012, Toucan, beneficially owned (including unexercised warrants) 120,558,957 shares of common stock,
representing a beneficial ownership interest of approximately 56%.



In
addition to financing obtained from Toucan and related entities, the Company has raised additional capital by issuing common stock
and debt securities. As of June 30, 2012 the Company had approximately $0.4 million of cash and cash equivalents on hand. The
Company will need to raise additional capital in the near future to continue to fund its clinical trials and other operating activities
and there can be no assurance that its efforts to seek such funding will be successful. The Company may seek funding from Toucan
Capital or Toucan Partners or their affiliates or other third parties. Such parties are under no obligation to provide the Company
with any additional funds, and any such funding may be dilutive to stockholders and may contain restrictive covenants. The Company
is currently exploring additional financings with several other parties; however, there can be no assurance that the Company will
be able to complete any such financings or that the terms of such financings will be attractive to the Company. If the Company’s
capital raising efforts are unsuccessful, its inability to obtain additional cash as needed could have a material adverse effect
on the Company’s financial position, results of operations and the Company’s ability to continue its existence.





12









6. Notes
Payable









NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



Notes
payable consist of the following at June 30, 2012 and December 31, 2011(in thousands):



|                                                                                                        |  | June 30, |        |  | December 31, | 
|------------------------------------------------------------------------------------------------------- |  | -------- | ------ |  | ------------ | 
|                                                                                                        |  | 2012     |        |  | 2011         | 
|                                                                                                        |  |          |        |  |              | 
|Notes payable - current                                                                                 |  |          |        |  |              | 
|12% unsecured originally due July 2011                                                                  |  | $        | 935    |  |              | 
|6% unsecured  due May 16, 2013 (net of discount of $0 in 2012 and $236 in 2011)                         |  |          | 2,000  |  |              | 
|12% unsecured originally due March 2011                                                                 |  |          | 450    |  |              | 
|                                                                                                        |  | $        | 3,385  |  |              | 
|                                                                                                        |  |          |        |  |              | 
|Notes payable related parties - current                                                                 |  |          |        |  |              | 
|12% unsecured due June 2012 (net of discount of $0 in 2012 and $21 in 2011)                             |  | $        | 2,077  |  |              | 
|                                                                                                        |  |          |        |  |              | 
|Convertible notes payable, net - current                                                                |  |          |        |  |              | 
|6% unsecured due between March 2011 and February 2012 (net of discount of  $0 in 2012 $34 in 2011)      |  |          | 2,520  |  |              | 
|10% unsecured due between April 2011 and February 2012  (net of discount of $0 in 2012 and $38 in 2011) |  |          | 138    |  |              | 
|10% unsecured convertible note due November 2012 (net of discount of $833 in 2012 and $1,833 in 2011)   |  |          | 2,167  |  |              | 
|6% unsecured due June 2012 (net of discount of $432 in 2012 and $182 in 2011)                           |  |          | 659    |  |              | 
|8% unsecured convertible note due April 2013 (net of discount of $1,129 in 2012)                        |  |          | 2,294  |  |              | 
|                                                                                                        |  | $        | 7,778  |  |              | 
|                                                                                                        |  |          |        |  |              | 
|Convertible notes payable related party, net - current                                                  |  |          |        |  |              | 
|12% unsecured due June 2012 (net of discount of $93 in 2011)                                            |  | $        | -      |  |              | 
|10% unsecured due within 6 months (net of discount of $46)                                              |  |          | 4,318  |  |              | 
|6% due July 2011 and November 2011 (net of discount of $92 in 2011)                                     |  |          | 1,390  |  |              | 
|                                                                                                        |  | $        | 5,708  |  |              | 
|Long term notes payable                                                                                 |  |          |        |  |              | 
|6% unsecured note due October 2012                                                                      |  | $        | 200    |  |              | 
|                                                                                                        |  |          |        |  |              | 
|Long term convertible notes, net                                                                        |  |          |        |  |              | 
|4% unsecured due November 15, 2013 (net of discount of  $31 in 2012 and $42 in 2011)                    |  | $        | 353    |  |              | 
|4% unsecured due June 30, 2013 (net of discount of $9 in 2011)                                          |  |          | -      |  |              | 
|11% unsecured convertible note due December 2013 (net of discount of $38 in 2012 and $321 in 2011)      |  |          | 128    |  |              | 
|10% unsecured convertible note due May 2015 (net of discount of $710 in 2012)                           |  |          | 662    |  |              | 
|                                                                                                        |  | $        | 1,143  |  |              | 
|                                                                                                        |  |          |        |  |              | 
|Total notes payable, net                                                                                |  | $        | 20,291 |  |              | 



The holders
of notes payable with an aggregate principal balance of $4.7 million converted the notes into 14.2 million shares of common stock
during the six months ended June 30, 2012.



The Company
received aggregate proceeds of $8.5 million in connection with issuing various notes during the six months ended June 30, 2012.
Warrants for the purchase of 19.3 million shares of common stock were also issued in connection with the notes. The notes are
payable on various dates through May 2015 and have interest rates from between 8% and 11%. The conversion prices of the notes,
with fixed terms, range between $0.33 and $0.40.



The company is currently negotiating the repayment terms for notes payable which
are past due.





7. Reclassified Equity Contracts



The
Company accounts for potential shares that can be converted to common stock and that if converted, will be in excess of authorized
shares, as a liability that is recorded on the balance sheet (at fair value) only until the authorized number of shares is increased
(at which time the whole liability will be re-measured, with changes in value included in other income/ (expense), and then reclassified
to additional paid-in capital). The value of the liability was computed by valuing the securities that management believed were
most likely to be converted. This liability is revalued at each reporting date with any change in value included in other income/
(expense) until such time as enough shares are authorized to cover all potentially convertible instruments.



As
a result of the Company entering into convertible promissory notes and issuing stock options, and warrants to purchase
common stock, the Company's total potential outstanding common stock exceeded the Company's authorized shares by
approximately 109 million shares at December 31, 2011. During 2012, the number of potential shares in excess of authorized
shares increased to approximately 112 million. Effective February 6, 2012, the number of authorized common shares was
increased to 450 million and the liability for potential shares in excess of total authorized shares was revalued at that
date. This valuation resulted in non-cash gain of approximately $0.5 million during the six months ended June 30, 2012. The
liability reclassified to additional paid in capital (and thereby removed from the Company’s liabilities) during the
six months ended June 30, 2012 amounted to approximately $30 million.



13







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



8. Net Income (Loss) Per Share
Applicable to Common Stockholders



Basic
net loss per share is calculated based on the weighted average number of common shares outstanding during the reporting period.
Diluted loss per share is computed on the basis of the weighted average number of common shares plus dilutive potential common
shares outstanding using the treasury stock method. The potentially dilutive securities are antidilutive due to the Company's
net losses and are as follows for all periods presented (in thousands):



|                                         |  | Six Months Ended |        
|---------------------------------------- |  | ---------------- | -------
|                                         |  | June 30          |        
|                                         |  | 2012             |        
|                                         |  |                  |        
|Common stock options                     |  |                  | 25,179 
|Common stock warrants                    |  |                  | 78,400 
|Convertible notes                        |  |                  | 43,354 
|Excluded potentially dilutive securities |  |                  | 146,933



9. Related Party Transactions



Cognate BioServices



During
the quarter ended June 30, 2011, the Company entered into a new service agreement with Cognate Therapeutics, Inc. (“Cognate”),
a contract manufacturing and services organization in which Toucan Capital has a majority interest. In addition, two of the principals
of Toucan Capital are members of Cognate’s board of directors and Linda Powers who is a director of Cognate and managing
director of Toucan Capital is Chairperson of the Company’s Board of Directors and Chief Executive Officer of the Company.
This agreement replaces the agreement dated May 17, 2007 between the Company and Cognate, which had expired. Under the service
agreement, the Company agreed to continue to utilize Cognate’s services, for certain consulting and manufacturing services
to the Company for its ongoing DCVax®-Brain Phase III clinical trial. The scope of services and the economics are comparable
to the prior agreement, and the structure and process for payments are simplified. Under the terms of the new agreement the Company
will pay Cognate a monthly facility fee and a fixed fee (in lieu of cost-plus charges) for each patient in the study, subject
to specified minimum number of patients per month, plus charges for certain patient and product data services if such services
are requested by the Company. The current service agreement expires on March 31, 2016.



During
the three months ended June 30, 2012 and 2011, respectively, the Company recognized approximately $3.8 million and
$1.7 million, respectively, of research and development costs related to these service agreements. During the six months
ended June 30, 2012 and 2011, respectively, the company recognized approximately $6.0 million and $3.4 million, respectively,
of research and development costs related to these service agreements. As of June 30, 2012 and December 31 2011, the Company
owed Cognate approximately $3.3 million and $0.6 million, respectively.



During
2009, the Company and Cognate agreed that some or most of the accounts payable owed by the Company to Cognate, will be converted
into shares of common stock instead of paid in cash.  The conversion price and terms will be no less favorable than the conversion
price and terms applied to any other creditor of the Company.  The Company will recognize the value of common stock issued
in excess of the amount of accounts payable converted, if any, as a charge to operations when the conversion takes place.



Toucan Capital and Toucan
Partners



In
accordance with a recapitalization agreement between the Company and Toucan Capital, as amended, pursuant to which Toucan Capital
agreed to recapitalize the Company by making loans to the Company, Toucan paid certain legal and other administrative costs on
the Company’s behalf. Pursuant to the terms of the Conversion Agreement discussed above, the recapitalization agreement
was terminated on June 22, 2007. Subsequent to the termination of the recapitalization agreement, Toucan Capital continued to
incur costs on behalf of the Company. These costs include consulting costs, travel expenses and other costs incurred in support
of the Company’s operations, product pipeline and international expansion efforts. In addition, since July 1, 2007 the Company
has accrued and recorded rent expense due to Toucan Capital Corp. an affiliate of Toucan Capital for its office space in Bethesda,
Maryland.



14







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



During
2009, the Company agreed with Toucan Capital, Toucan Partners and Linda Powers that some or all of the payables owed by the Company
to these parties for certain expense reimbursements will be converted into shares of common stock instead of paid in cash.The
conversion price and terms will be no less favorable than the conversion price and terms applied to any other creditor of the
Company. The parties are in the process of determining the amounts of such payables. The Company will recognize the value of common
stock issued in excess of the amount of the accrued expenses converted, if any, as a charge to operations when the conversion
takes place. Finalization of these arrangements is in process.



The
Company terminated its sub-lease with Toucan Capital Corporation on December 31, 2009. Under the sub-lease, the Company was responsible
for its portion of the lease obligations with the landlord, on a straight pass-through basis. Those obligations included rent
payments to the landlord for the remaining unused term of the lease. Pursuant to an extended payment arrangement with the landlord,
those payments are to be made over a number of years. The Company's obligation will be approximately $127,000 in 2012.



In
November, 2011, Toucan provided the collateral required by an unrelated investor for a loan of $2 million to the Company. The
investor required that Toucan place in escrow, as collateral to secure repayment of the loan and accumulated
interest, approximately 6.5 million shares of common stock of the Company owned by Toucan. Toucan placed such shares in
escrow as required. The investor’s loan had a maturity of six months, expiring in May, 2012. In August 2012, the
Company agreed to indemnify and compensate Toucan for providing the loan collateral by issuing to Toucan warrants equal to
fifty percent of the number of shares provided as collateral by Toucan, with an exercise price of $0.40 and an exercise term
of five years. At maturity, the Company did not repay the note, but entered into a six-month extension with the investor. The
investor required that the shares of common stock previously provided as collateral by Toucan remain in escrow as collateral
during the six-month extension term. In August 2012, the Company also agreed to compensate Toucan for the extension term on the
collateral by issuing to Toucan warrants equal to fifty percent of the shares kept in escrow for the extension period. The
extension period warrants have an exercise price of $0.35 and an exercise period of five years.



Notes Payable - Related Parties





Al
Rajhi converted the note payable with a principal balance of $2,523,201 into 4,426,670 shares of common stock on February 9, 2012.



In
July 2009, the Company issued a convertible note to Toucan Partners for $1.1 million of financing from Toucan Partners to the
Company.  The note carried ten percent original issue discount and an interest rate of ten percent.  The note is convertible
at a fixed price of $0.20 per share.  The note had a 2-year maturity, and was due in July 2011.  The note carried one
hundred percent warrant coverage, with the warrants exercisable at the same price as the conversion price, and an exercise period
of five years.  The Company did not repay the note at its maturity and the note is still outstanding.  The Company and
Toucan have agreed to extensions on the same terms as the extensions of unrelated investors whose notes have not been repaid.



The
Company received proceeds of $1,500,000 in connection with issuing a convertible note to Toucan Partners on February 9, 2012.
Warrants to purchase 6,679,688 shares of common stock were issued in connection with the note. Theexercise price will be $0.40
if certain waivers of anti-dilution provisions can be obtained, and if not the exercise price will be $0.57 per share. The note
is unsecured, but will become secured if the Company enters into any secured financing or if there is an event of default, as
defined. The note is payable on demand with 14 days written notice and carried an original issue discount of 10% and a one-time
interest charge of 10%. The conversion price of the note is 95% of the average of the lowest five days’ closing prices of
the Company's common stock in thetwenty trading days prior to conversion.



The
Company received proceeds of $1,255,000 in connection with issuing unsecured convertible notes to Toucan Partners on dates between
January 3, 2012 and March 6, 2012. The notes carried 100% warrant coverage. The exercise price will be $0.40 if certain waivers
of anti-dilution provisions can be obtained, and if not the exercise price will be $0.57 per share. The notes are payable on demand
with between 7 and 14 days written notice and carried an original issue discount of 10% and a one-time interest charge of 10%.
The conversion prices of the notes are 95% of the average of the lowest five days’ closing prices of the Company's common
stock in the twenty trading days prior to conversion..



The
Company received proceeds of $200,000 in connection with issuing an unsecured convertible note to an officer of the Company on
January 3, 2012. The notes carried 100% warrant coverage. The exercise price will be $0.40 if certain waivers of anti-dilution
provisions can be obtained, and if not the exercise price will be $0.57 per share. The note is payable on demand with 7 days written
notice and carried an original issue discount of 10% and a one-time interest charge of 10%. The conversion price of the note is
95% of the average of the lowest five days’ closing prices of the Company's common stock in the twentytrading days prior
to conversion.





The
Company received proceeds of $280,000 in connection with issuing an unsecured convertible demand note to an officer of the Company
on June 29, 2012. The conversion price was $0.33 and the interest rate was 10%. The notes carried 100% warrant coverage.The exercise
price is $0.35 and the terms of the warrants are five years.



The Company
received proceeds of $0.7 million in 2011 on an operational loan basis, from Artecel, Inc. Artecel is controlled by Toucan
Capital Corp. Repayment terms as well as warrant coverage were agreed to in August 2012. The Note now carries original
issue discount of ten percent, an interest rate of ten percent, and a six-month maturity. The loan is convertible at 90% of
the average of the lowest five days’ closing prices of the Company’s common stock in the twenty trading days
prior to conversion. The loan carries one hundred percent warrant coverage, with an exercise price of $0.40, and an exercise
period of five years. The Company and Artecel have entered into three extensions of this note. In consideration of
the extensions, the Company agreed to issue warrants to Artecel on the same basis as the warrants issued to unrelated
angel investors for note extensions.





Other
Related Parties



During
2010, 2011 and 2012 year to date, a Board member of the Company arranged multiple financings for the Company,
totaling approximately $8.0 million. The Company agreed to compensate the Board member at a rate below the usual fees of
investment banks for such transactions, by paying the Board member total fees of ten percent, with most of such fees in the
form of restricted common stock of the Company. The number of shares of restricted stock has yet to be determined as of
August 2012.

15







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



10. Stockholders’ Equity
(Deficit)



Common Stock Issuances



Issuances of
common stock during 2012 were as follows (shares and dollars in thousands):



|                                        |  | Shares |        |  | Purchase/Conversion |  |      | Proceeds/Debt | 
|--------------------------------------- |  | ------ | ------ |  | ------------------- |  | ---- | ------------- | 
|Description                             |  | Issued |        |  | Price               |  |      | Conversion    | 
|                                        |  |        |        |  |                     |  |      |               | 
|Issuance of shares to private investors |  |        | 227    |  |                     |  | 0.33 |               | 
|Issuance of shares to private investors |  |        | 217    |  |                     |  | 0.27 |               | 
|Conversion of notes payable             |  |        | 9,441  |  |                     |  | 0.39 |               | 
|Conversion of accounts payable          |  |        | 47     |  |                     |  | 0.32 |               | 
|Total 1st Quarter 2012                  |  |        | 9,932  |  |                     |  |      |               | 
|                                        |  |        |        |  |                     |  |      |               | 
|Issuance of shares to private investors |  |        | 900    |  |                     |  | 0.23 |               | 
|Conversion of notes payable             |  |        | 368    |  |                     |  | 0.14 |               | 
|Conversion of notes payable             |  |        | 4,807  |  |                     |  | 0.18 |               | 
|Shares issued for consulting services   |  |        | 11     |  |                     |  | 0.25 |               | 
|Total 2nd Quarter 2012                  |  |        | 6,086  |  |                     |  |      |               | 
|                                        |  |        |        |  |                     |  |      |               | 
|Total  Six Months Ended June 30, 2012   |  |        | 16,018 |  |                     |  |      |               | 



Stock Purchase Warrants



Through
June 30, 2012, the Company has issued warrants to strategic partners, consultants and investors with exercise prices ranging from
$0.15 to $3.24 and contractual lives ranging from three to five years. The following is a summary of warrant activity for the
three months ended June 30, 2012:



|                                    |  | Number of |            |  | Weighted Average |  
|----------------------------------- |  | --------- | ---------- |  | ---------------- | -
|                                    |  | Warrants  |            |  | Exercise Price   |  
|                                    |  |           |            |  |                  |  
|Outstanding as of December 31, 2011 |  |           | 57,092,920 |  |                  | $
|Issued                              |  |           | 21,307,559 |  |                  |  
|Outstanding as of June 30, 2012     |  |           | 78,400,479 |  |                  | $



11. Subsequent Events



On July 16,
2012, the Company entered into a Securities Purchase Agreement (the “SPA”) for the sale of a Note and warrants (the
“Warrants”) to purchase shares of common stock. Pursuant to the SPA, the Company issued a Note in the amount of $1,100,000
and Warrants exercisable at $0.40 per share to purchase 1,250,000 shares of common stock.



The Note matures
on January 16, 2013. The Note includes an Original Issue Discount of ten percent. If the Note is repaid by November 16, 2012,
there is no interest charge. If it is repaid after that date, there is a one-time interest payment of 10% that will be applied
to the outstanding principal. The Note may be prepaid at any time. The Note also provides for repayment upon the closing of the
earlier of (1) any financing transaction or series of financing transactions with gross proceeds of at least $10,000,000 or (2)
the Company’s proposed offering pursuant to the registration statement on Form S-1 filed on June 29, 2012 (the “Public
Offering”). The Note is convertible into shares of the Company’s common stock at a price of 80% of the market price
at the time of conversion, determined according to a market based formula. The Warrants do not become exercisable until 90 days
following the closing of the Public Offering, provided that the Public Offering or an equivalent financing closes within 90 days
of the issuance date. The Warrants are exercisable for a period of four years. The Warrants may be exercised on a cashless basis
if there is no effective registration statement registering the resale of the underlying shares.



16







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



The
Company paid an origination amount of 750,000 shares covering both this $1.1 million financing and a recent $500,000
investment by the same party. The Company paid a placement agent amount of 500,000 shares. The placement agent also received
a fee of 8% of the gross proceeds to the Company.



On July 25,
2012, the Company announced that its partner in Germany, Fraunhofer IZI, has received the official approval and certification
from the regional and national regulatory agencies in Germany (including the Paul-Ehrlich-Institut, or PEI – the
German equivalent of the U.S. FDA) for the manufacture of the Company’s DCVax®-L immune therapy for human patients with
Glioblastoma multiforme brain cancer.



On August 8,
2012, the “Company announced that it entered  into amended agreements to double the production capacity in the U.S.
for the manufacture of the Company’s DCVax®-L immune therapy for Glioblastoma multiforme patients and also announcing
that the Company’s German partner, Fraunhofer IZI, has all of the necessary regulatory approvals and is fully operational
for manufacturing of DCVaX®-L, and the Company’s UK Partner, Kings College Hospital, also has all of the necessary regulatory
approvals and is in the final stages of preparations for such manufacturing. The Company further announced that both of its European
partners will be able to deliver DCVaX®-L anywhere in Europe.



On August 8,
2012, the Company entered into a Securities Purchase Agreement (the “Agreement”) for the sale of OID Convertible Notes
(the “OID Notes”) and warrants (the “August 2012 Warrants”) to purchase shares of common stock of the
Company. Pursuant to the Agreement, the Company issued Notes in the aggregate principal amount of $1,136,665 and August 2012 Warrants
exercisable at $0.35 per share to purchase an aggregate 1,894,444 shares of common stock of the Company.



The OID Notes
mature on December 4, 2012. No interest shall accrue on the OID Notes unless there is an event of default. The OID Notes may be
prepaid at any time upon notice to the holders of the OID Notes The OID Notes are convertible at any time into shares of common
stock at a conversion price of $0.30 per share subject to adjustment. The August 2012 Warrants are exercisable at any time up
until five (5) years after the date of issuance. The August 2012 Warrants may be exercised on a cashless basis if there is no
effective registration statement registering the resale of the underlying shares. If the Company issues any common stock or common
stock equivalents at a price below the exercise price of the August 2012 Warrants (the “Base Share Price”), the exercise
price of the August 2012 Warrants shall be reduced to the Base Share Price.





Other



Between July and
August 2012, the Company converted $1.7 million of liabilities into 9.6 million shares of common stock.



Item 2.
Management’s Discussion and Analysis of Financial Condition and Results of Operations



The
following discussion and analysis of our financial condition and results of operations should be read in conjunction with our
unaudited condensed consolidated financial statements and the notes to those statements included with this report. In addition
to historical information, this report contains forward-looking statements within the meaning of Section 27A of the Securities
Act of 1933, as amended (the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended
(the “Exchange Act”). Such forward-looking statements are subject to certain risks and uncertainties that could cause
actual results to differ materially from those projected. The words “believe,” “expect,” “intend,”
“anticipate,” and similar expressions are used to identify forward-looking statements, but some forward-looking statements
are expressed differently. Many factors could affect our actual results, including those factors described under “Risk Factors”
elsewhere in this report. These factors, among others, could cause results to differ materially from those presently anticipated
by us. You should not place undue reliance on these forward-looking statements.



Overview



We
are a development stage biotechnology company focused on discovering, developing and commercializing immunotherapy products to
generate and enhance immune system responses to treat cancer. Data from our clinical trials suggest that our cancer therapies
significantly extend both the time to tumor recurrence and patient survival time, while providing a superior quality of life with
no debilitating side effects when compared with current therapies.



Our
financing activities are described below under “- Liquidity and Capital Resources”. We will need to raise additional
capital to fund our operations, including our Phase III DCVax ® -L clinical trial. If the results of our Phase III trial are
positive, we plan to seek early product approval for DCVax®-L, at the end of this trial.



We have
experienced recurring losses from operations and as of June 30, 2012 we have a deficit accumulated during the development
stage of $272.1million, and have used $125.6 million for operating cash flows.



17







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



In addition,
our independent registered public accounting firm’s report on the financial statements for the year ended December 31, 2011,
states that because of recurring operating losses, net operating cash flow deficits, and a deficit accumulated during the development
stage, there is substantial doubt about the Company’s ability to continue as a going concern.



Critical Accounting Policies
and Estimates



Our
discussion and analysis of our financial condition and results of operations are based on our financial statements, which have
been prepared in accordance with U.S. GAAP. The preparation of these financial statements requires us to make estimates and judgments
that affect our reported amounts of assets, liabilities, revenues and expenses.



On
an ongoing basis, we evaluate our estimates and judgments, including those related to accrued expenses and stock-based compensation.
We based our estimates on historical experience and on various other assumptions that we believe to be reasonable under the circumstances,
the results of which form the basis for making judgments about the carrying values of assets and liabilities and the reported
amounts of revenues and expenses that are not readily apparent from other sources. Actual results may differ from these estimates.



Our
critical accounting policies and significant estimates are detailed in our Annual Report on Form 10-K for the year ended December
31, 2011. Our critical accounting policies and significant estimates have not changed substantially from those previously disclosed
in our Annual Report on Form 10-K for the year ended December 31, 2011.



Recent Accounting Pronouncements



See Note 2
to Condensed Consolidated Financial Statements in this Form 10-Q.



Results of Operations



Operating costs:



Operating
costs and expenses consist primarily of research and development expenses, including clinical trial expenses which increase when
we are actively participating in clinical trials (and are especially high when we are in a phase III trial, as we now are), and
general and administrative expenses.



Research and development:



Discovery
and preclinical research and development expenses include scientific personnel-related salary and benefit expenses, costs of laboratory
supplies used in our internal research and development projects, travel, regulatory compliance, and expenditures for preclinical
and clinical trial operation and management when we are actively engaged in clinical trials.



Because
we are a development stage company, we do not allocate research and development costs on a project basis. We adopted this policy,
in part, due to the unreasonable cost burden associated with accounting at such a level of detail and our limited number of financial
and personnel resources.



General and administrative:



General
and administrative expenses include administrative personnel related salary and benefit expenses, cost of facilities, insurance,
travel, legal support, property and equipment and amortization of stock options and warrants.



Three Months Ended June 30, 2012
and 2011



We
recognized a net loss of $10.1 million for the three months ended June 30, 2012 compared to a net loss of $12.3 million for
the three months ended June 30, 2011. The decrease in net loss was primarily attributable to increased non-cash stock option
expenses incurred due to the grants of stock options to the new management team in June 2011, a $1.5 million non-cash charge
incurred in the 2nd quarter of 2011 related to the valuation of reclassified equity contracts as discussed in Note
4, Fair value Measurements, offset by, increased research and development expenses.



Research
and Development Expense. Research and development expense was $7.0 million for the three months ended June 30, 2012 compared
to $3.5 million for the three months ended June 30, 2011. The increase was primarily attributable to increased number of clinical
trial sites open and recruiting across the United States in our ongoing Phase III clinical trial of DCVax®-L immune therapy
for Glioblastoma multiforme (GBM), the most lethal form of brain cancer. As of June 30, 2012 we had 41 clinical trial sites in
operation in the U.S., compared to 12 clinical trial sites at June 30, 2011.



18







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



General
and Administrative Expense. General and administrative expense was $2.0 million for the three months ended June 30, 2012
compared to $5.6 million for the three months ended June 30, 2011. The decrease was primarily due to incremental stock
compensation expense related to the grant of stock options to the new management team in June 2011.



Valuation
of reclassified equity contracts. During the three months ended June 30, 2012, we did not recognize a non-cash gain from
the valuation of reclassified equity contracts because there were no contracts required to be accounted for as liabilities
during the 2nd quarter of 2012. There was a non-cash  charge of $1.5 million in reclassified equity contracts
during the three months ended June 30, 2011.



Derivative
valuation gain and loss. During the three months ended June 30, 2012 we recognized a gain on derivative liabilities of
$0.2 million due to the decrease in time value remaining on this liability based financial instrument. We recognized a $0.1
million loss in the three months ended June 30, 2011.



Interest
(Expense). Interest expense was $1.6million for the three months ended June 30, 2012 and June 30, 2011.



Six Months Ended June 30, 2012
and 2011



We
recognized a net loss of $20.3 million for the six months ended June 30, 2012 compared to a net loss of $20.7 million for the
six months ended June 30, 2011.



Research
and Development Expense. Research and development expense was $10.6 million for the six months ended June 30, 2012
compared to $7.9 million for the six months ended June 30, 2011. The increase was primarily attributable to increased number
of clinical trial sites open and recruiting across the United States in our ongoing Phase III clinical trial of DCVax®-L
immune therapy for Glioblastoma multiforme (GBM) brain cancer.



General
and Administrative Expense. General and administrative expense was $4.3 million for the six months ended June 30, 2012 compared
to $7.9 million for the six months ended June 30, 2011. The decrease was primarily due to an incremental $2.2 million of stock
compensation expense primarily related to the grant of stock options to the new management team in June 2011.



Valuation
of reclassified equity contracts. During the six months ended June 30, 2012, the Company recognized a non-cash gain amounting
to $0.5 million from the decrease in value of reclassified equity contracts. There was a non-cash loss of $1.5 million in reclassified
equity contracts during the six months ended June 30, 2011.



Derivative
valuation gain and loss. During the six months ended June 30, 2012 we recognized a gain on derivative liabilities of
$0.5 million due to the change in value of the financial instruments. We recognized a $0.3 million loss in the six months
ended June 30, 2011.



Interest
(Expense). Interest expense increased to $6.8 million for the six months ended June 30, 2012 from $3.1 million for the six
months ended June 30, 2011. Interest expense increased for the six month period ended June 30, 2012 primarily related to the increased
borrowing costs and terms of the convertible notes payable that were initiated during the six month period ended June 30, 2012.



Liquidity and Capital Resources



At
June 30, 2012, cash totaled $0.4 million, compared to $24,000 at December 31, 2011. Working capital was a deficit of $29.4 million
at June 30, 2012, compared to a deficit of $50.6 million at December 31, 2011. The working capital deficit decreased as of June
30, 2012 as compared to December 31, 2011 primarily due to the decrease in the liability for reclassified equity contracts in
2012.



19







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



The
change in cash for the periods presented was comprised of the following (in thousands):



|                                                      |  | Six Months Ended |        |   |      |  
|----------------------------------------------------- |  | ---------------- | ------ | - | ---- | -
|                                                      |  | June 30,         |        |   |      |  
|                                                      |  | 2012             |        |   | 2011 |  
|                                                      |  |                  |        |   |      |  
|Net cash provided by (used in):                       |  |                  |        |   |      |  
|Operating activities                                  |  | $                | (8,374 | ) |      | $
|Investing activities                                  |  |                  | (27    | ) |      |  
|Financing activities                                  |  |                  | 8,847  |   |      |  
|Effect of exchange rates on cash and cash equivalents |  |                  | (40    | ) |      |  
|Increase in cash and cash equivalents                 |  | $                | 406    |   |      | $



Operating
Activities



We
used $8.4 million in cash for operating activities during the six months ended June 30, 2012. The increase in cash used in operating
activities was primarily attributable to increased number of clinical trial sites open and recruiting across the United States
in our ongoing Phase III clinical trial of DCVax®-L immune therapy for GBMbrain cancer.



Investing
Activities



Investing
activities for the periods presented are not material.



Financing
Activities



During
the six months ended June 30, 2012, our financing activities consisted of net proceeds from notes payable amounting to
$8.8 million and proceeds from the issuance of common stock amounting to $0.3 million. The increase in our financing
activities was primarily attributable to increased number of clinical trial sites open and recruiting across the U.S. in our
ongoing Phase III clinical trial of DCVax®-L immune therapy for GBMbrain cancer.



In
order to continue with our current activities under our DCVax- ®- -L program, we will have to obtain substantial amounts of
further funding. Our ongoing funding requirements will depend on many factors, including the number of staff we employ, the pace
of patient enrollment in our brain cancer trial, the cost of establishing clinical studies and compassionate use/named patient
programs in other countries, and unanticipated developments. Without additional capital, we will not be able to continue significant
enrollment in our DCVax®-L clinical trial or move forward with compassionate use/named patients programs or with any of our
other product candidates for which investigational new drug applications have been cleared by the FDA. We will also be constrained
in developing improved manufacturing processes.



The
additional funding will be required in the near future and there can be no assurance that our efforts to seek such funding will
be successful. If our capital raising efforts are unsuccessful, our inability to obtain additional cash as needed could have a
material adverse effect on our financial position, results of operations and our ability to continue our existence. We may seek
additional funds through the issuance of additional common stock or other securities (equity or debt) convertible into shares
of common stock, which could dilute the ownership interest of our stockholders. We may seek funding from Toucan Capital or Toucan
Partners or their affiliates or other third parties. Such parties are under no obligation to provide us any additional funds,
and any such funding may be dilutive to stockholders and may contain restrictive covenants that could limit our ability to take
certain actions.



Item 4. Controls and Procedures



Evaluation of Disclosure Controls
and Procedures



Under
the supervision and with the participation of our management, including our principal executive, financial and accounting officer,
we conducted an evaluation of our disclosure controls and procedures, as such term is defined under Rule 13a-15(e) promulgated
under the Securities Exchange Act of 1934, as amended. Based on this evaluation, our principal executive, financial and accounting
officer concluded that, as of June 30, 2012, in light of the material weaknesses identified in our management report on internal
controls and procedures contained in our Form 10-K for the fiscal year ended December 31, 2011, Item 9A filed on April 13, 2012,
our disclosure controls and procedures were not effective to ensure that the information required to be disclosed by us in the
reports that we file or submit under the Securities Exchange Act of 1934 is accumulated and communicated to management, including
our chief executive officer, financial and accounting officer, to allow timely decisions regarding required disclosure, and that
such information is recorded, processed, summarized and reported within the time periods prescribed by the SEC.



20







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



Changes in Internal Control over
Financial Reporting



There
has been no change in our internal controls over financial reporting that occurred during the fiscal quarter ended June 30, 2012,
that has materially affected, or is reasonably expected to materially affect, our internal controls over financial reporting.



Part II
- Other Information



Item 1. Legal Proceedings



From
time to time, we are involved in claims and suits that arise in the ordinary course of our business. Although management currently
believes that resolving any such claims against us will not have a material adverse impact on our business, financial position
or results of operations, these matters are subject to inherent uncertainties and management’s view of these matters may
change in the future.



Item 2. Unregistered Sales of
Equity Securities and Use of Proceeds



On January
20, 2012, we issued 227,273 shares of common stock to an affiliated investor at $0.33 per share for net proceeds of $75,000.



On February
27, 2012, we issued 216,666 shares of common stock to a private investor at $0.27 per share for net proceeds of $65,000.



On May 15,
2012, we issued 900,000 shares of common stock to a private investor at $0.23 per share for net proceeds of $207,000.



On August 8,
2012, we entered into a Securities Purchase Agreement (the “Agreement”) for the sale of OID Convertible Notes (the
“OID Notes”) and warrants (the “August 2012 Warrants”) to purchase shares of our common stock. Pursuant
to the Agreement, we issued Notes in the aggregate principal amount of $1,136,665 and August 2012 Warrants exercisable at $0.35
per share to purchase an aggregate 1,894,444 shares of common stock.



The
sales of the securities identified above were made pursuant to privately negotiated transactions that did not involve a public
offering of securities and, accordingly, we believe that these transactions were exempt from the registration requirements of
the Securities Act pursuant to Section 4(2) of the Securities Act and Rule 506 of Regulation D. The agreements executed in connection
with these sales contain representations to support the Company’s reasonable belief that the Investors had access to information
concerning the Company’s operations and financial condition, that the Investors acquired the securities for their own account
and not with a view to the distribution thereof in the absence of an effective registration statement or an applicable exemption
from registration, and that the Investors are sophisticated within the meaning of Section 4(2) of the Securities Act and are “accredited
investors” (as defined by Rule 501 under the Securities Act). In addition, the issuances did not involve any public offering;
the Company made no solicitation in connection with the sale other than communications with the Investor; the Company obtained
representations from the Investor regarding their investment intent, experience and sophistication; and the Investor either received
or had access to adequate information about the Company in order to make an informed investment decision. All of the foregoing
securities are deemed restricted securities for purposes of the Securities Act.



Item 5.
Other Information



On August 8,
2012, we entered into a Securities Purchase Agreement (the “Agreement”) for the sale of OID Convertible Notes (the
“OID Notes”) and warrants (the “August 2012 Warrants”) to purchase shares of common stock. Pursuant to
the Agreement, we issued Notes in the aggregate principal amount of $1,136,665 and August 2012 Warrants exercisable at thirty
five cents ($0.35) per share to purchase an aggregate 1,894,444 shares of common stock. The Agreement provides that so long as
any OID Notes are outstanding, in the event we consummate an equity offering for at least $20 million (the “Subsequent Offering”)
on terms with economic benefits which are equal to or better than the terms under the Agreement, then the holders of the OID Notes
shall have the right to purchase from us up to $2 million of reasonably equivalent securities on the same terms and conditions
as the Subsequent Offering. In addition, if prior to the date on which the OID Notes are due and payable, we receive funding from
our currently contemplated public offering or raise in excess of $10 million in a private placement, then at each holder’s
election, we shall redeem the OID Note.



21







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



The OID Notes
mature on December 4, 2012. No interest shall accrue on the OID Notes unless there is an event of default. The OID Notes may be
prepaid at any time upon notice to the holders of the OID Notes The OID Notes are convertible at any time into shares of common
stock at a conversion price of $0.30 per share subject to adjustment. The August 2012 Warrants are exercisable at any time up
until five (5) years after the date of issuance. The August 2012 Warrants may be exercised on a cashless basis if there is no
effective registration statement registering the resale of the underlying shares. If the Company issues any common stock or common
stock equivalents at a price below the exercise price of the August 2012 Warrants (the “Base Share Price”), the exercise
price of the August 2012 Warrants shall be reduced to the Base Share Price.



Item 6. Exhibits



|31.1 |  | Certification of President (Principal Executive Officer and Principal Financial
    and Accounting Officer), Pursuant to Exchange Act Rules 13a-14(a) and 15d-14(a), as Adopted Pursuant to Section 302 of the
    Sarbanes-Oxley Act of 2002.
|---- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|     |  |                                                                                                                                                                                                                                               
|32.1 |  | Certification of President,
Chief Executive Officer and Principal Financial and Accounting Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                                                 



22







NORTHWEST
BIOTHERAPEUTICS, INC.

(A Development
Stage Company)



SIGNATURES



Pursuant
to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf
by the undersigned thereunto duly authorized.



|                       | NORTHWEST BIOTHERAPEUTICS, INC
|---------------------- | ------------------------------
|                       |                               
|Dated: August 14, 2012 | By:                           
|                       |                               
|                       |                               
|                       |                               
|                       |                               



23