Exhibit 10.1
 NORTHWEST BIOTHERAPEUTICS, INC.
LOAN AGREEMENT and
PROMISSORY NOTE
 US $1 million
    
    August 19, 2008
 GENERAL.
 Toucan Partners Holder Northwest Biotherapeutics, Inc. Maker Company Principal Amount Note Repayment Amount OID
 Maturity Date
 PRE-PAYMENT .
  DEFAULT PAYMENT .
 Event of Default Default Principal SBA Default
Payments




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DEFAULTS .
 4.1 Definitions Event of Default
     Involuntary Petition
 4.2 Remedies on Default.
   2




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inter alia
 DEFENSES .
 5.1 No Offsets
 [INTENTIONALLY OMITTED]
 SECTION 7. EXTENSION OF MATURITY .
  SECTION 8. ATTORNEYS FEES AND COLLECTION FEES .
  SECTION 9. WAIVERS, DISPUTES, JURISDICTION .
 9.1 Waivers by Maker
 9.2 Actions of Holder not a Waiver
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9.3 Consent to Jurisdiction
 9.4 Waiver of Jury Trial
 9.5 Service of Process
 SECTION 10. COVENANTS .
 10.1 Affirmative Covenants
 Office
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Use of Proceeds FDA SEC
 Seniority pari passu
 Regulatory Information
 Business Activity
 10.2 Negative Covenants
 No Liens Liens pari passu
 No Conflicting Agreements
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No Distributions or Redemptions
 Other Limitations
    SECTION 11. STOCK ISSUANCE, STOCK PRICE
 11.1 Partial Repayment in Stock
 11.2 Default Payments
 11.3 Adjustments for Stock Splits, Dividends, Etc.
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SECTION 12. MAKERS REPRESENTATIONS AND WARRANTIES .
  12.1 Organization, Good Standing and Qualification
 12.2 Authorization
 12.3 No Conflicts
 12.4 Litigation
 12.5 No Liens
 12.6 Small Business.
 Small Business Status Federal Regulations Small Business Act SBIA
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Information for SBA Reports
 Eligibility
 SECTION 13. HOLDERS REPRESENTATIONS AND WARRANTIES
 Securities Act
 13.1 Investment Experience
 13.2 Investment Purpose
 13.3 No Solicitation
 13.4 Accredited Investor
 13.5 Access to Information
 13.6 Stock Legend
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SECTION 14. PIGGYBACK REGISTRATION RIGHTS.
 14.1 Piggyback Registrations . Registrable
Securities
 14.2 Underwriting Pre-existing Rights Holders
 14.4 Expenses Of Registration Registration Expenses
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SECTION 15. INDEMNIFICATION
 15.1 Indemnification.
 Indemnified Persons
  15.2 Survival
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SECTION 16. REPLACEMENT OF NOTE .
  SECTION 17. MISCELLANEOUS
 17.1 Notices
 if to Maker:
    
    Northwest Biotherapeutics, Inc.7600 Wisconsin AvenueSuite 750Bethesda, MD 20814Tel: (240) 497-4060Fax: (240) 497-4065Attention: Alton L. Boyntonaboynton@nwbio.comwith a copy to:
    
    David Engvall, Esq.Covington & Burling LLP1201 Pennsylvania Avenue, N.W.Washington, DC 20004-2401Tel: (202) 662-5307Fax: (202) 778-5307dengvall@cov.comif to Holder:
    
    Toucan Partners, LLC7600 Wisconsin AvenueBethesda, MD 20814Tel:Fax: (240) 497-4065Attention: Linda F. Powerslpowers@toucancapital.com
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17.2 Parties In Interest; Assignment
 17.3 Entire Agreement
 17.4 Severability
 17.5 Amendments
 17.6 Headings
 17.7 Governing Law
 17.8 Nature of Obligation
 17.9 Expenses
 17.10 No Third Party Rights
 17.11 Counterparts
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IN WITNESS WHEREOF
 NORTHWEST BIOTHERAPEUTICS, INC.
    
    TOUCAN PARTNERS, LLCBy:
    
    /s/Alton Boynton
    
    By:
    
    /s/ Linda F. PowersName: Alton Boynton
    
    
    
    Name: Linda F. PowersTitle: President
    
    
    
    Title: Managing Member
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