## / ,ffTS 16039;,1' O.M.B. No. 

### 2070-0012: 3t

# 1 

# &EPA United States Environmental Protection Agency 

# PREMANUFACTURE NOTICE

FOR NEW CHEMICAL SUBSTANCES AGENCY USE ONLY Oltte of receipt 

# DTS When 

### completed send this 

### form to 

## DOCUMENT CONTROL OFFICER OFFICE OF TOXIC SUBSTANCES. T$-793 U.S. E.P.A. 401 M STREET, SW WASHINGTON, D.C. 20460 

## I. Enterthetotal

## numbw of

## pages**!~** 

## inthe 

## Pra...-nutacture Notice 

## 17 

# GENERAL IIISTRUCTIONS Vou must provide all information requested 

### intlllis 

### fo•m**n~** 

### 1111e extent Uhat ill: is known t(l)**CDr~** ascertainable by you. Make reasonable estimates if you 

### do lOOt 

### haw aett&llill cdata. Befo•e you complete this form, you should reed 

### the "tlllSti!UCtions**~** 

### tCDr P1'811'Aal'llli>facture Notification" 

### llnetluctlona Menuell. P_.l - GENERAL INFORMATION You 

### must provide the chemicat identity of

### the new chemical substance. even if you claimthe identity 

### as confidential. You may authorize another person- tosubmft the identity for you, but your submission will not 

### becomplete and review will not begin until 

### EPA receives this information. 

### P_.ll- HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE You may need addi1ional copies of pert II, sections A and B ifthere are save•al manufacture, processing, or usa operations that you will describe in the notice. You should reproduce these sections 

### as 

### needed. 

### "P_.lll- LIST OF ATTACHMENTS You should attach addi1ional sheets ifyou 

### do not have enough space ontheform to answer a question fully. In pert 

### Ill, listthese attachments, any test data or other data, and any 

### optional information

### that you include in the notice. 

### OP'YIONAL INFORMATION You may include in the notice any information

### that you want 

### EPA to consider in evaluating the new substance. The**~** 

### M8nUIII identifies categories of optional information 

### that you may want 

### EPA to review. 

### CONFIDENTIALITY CLAIMS You may claim any information in this notice 

### as confidential'. 

### 1\'o assart a claim on the form, mark IX) the confidential box nelrt

### to the information that you claim 

### as confidentiat. 

### To 

### assert a claim·inan attachment, circle or bracket the infonmnion

### you claim 

### as confidential. Ifyou claim information ifl 

### the notice

### as confidential<, you must provide a sanitized version ofthe- notice, including; attachments, to 

### EPA with your submission. For additional instructions on claiming information- a&**confidential~** readlthe

### lnstructlona M........ Indicate betow the categofies of information you have• claimedIa& confidential iflthe noticeandth&type·of notice. 1 

# 0 SUBMmER IDENJiiFY 2 

# 0 CHEMICAL

### IDENJ~'FY 3

### ~ PRODUCTION VOI!.UME 4 

# 0 USE INFORMATION< 

# 50 PROCESS INFORMATION 6 

# 0 PORTIONS OF A MtX'li'URE 7 

# 0 OTHER INFORMATION 

## EPA Form7710.2&(•12-18-Mt 

# fXl PMN' 0TMEA 

### OsNt:JR 

# 0 ExemptiEm - 

### Speci#y**~** 

### TEST DATA A.a 

### OTMER DATA You •e required tG 

### II1Ubmit all test 

### data iA your possession Of c0!'11irol 

### and to provide a clescriptiol'l of all oti'ler 

### data known to or reasonably ascertainable by you i<f these data are related to the health and environmental effects of the**manutactu~e.** processing, distribution in**corn~rce,** 

### use. or disposal ofthe new chemical substance. Standard literature citations mB¥ l!le submitted for data in the open scientific literature. Comptete test cdata, !'lOt summaries of data, must 

### be**submit~oed** 

### ifthey 

### do not 

### appear 

### iA the open literature. Following ••**exa~nptes** of test 

### data and other data. You should submit 

### tMS8 data according to 

### the**r~~nts** of 

### §720.50 of the Premanuf!IC't\M'e NotificMion Rule 

### (40 CFR Part 

### 720). 

### T_. ... 

### • Elw.,••aitaltaeectMa**~~ ~U'V,**  visib6e, and infrared) Del'lsity of liQutcts 

### and solids 

### WlJier**so~w~Ditity** MehilllfJ JIIC!)illlltlmelting range Boilil'lg JIICI)int/boiing range 

# v.,.,.. (11118SSW1'8 

### PartlhiGMn cC!IefflicieAt, 1'1-octanoMwatl!el' 

### .,_,aGatiolll Hy0.flll¥sis 

### (.as afwnctiol'l of pHl) Pl!!rottDCirlemical degracialtion**A~iol!l/desorption** to 

### soil types DissociMiCI)III CCim&t!JIIllt Other (lli!l¥sical1cf!lemical IIJII'opel"ties 

# ................. Mwl!agenicity CBI!ciiiiC!lfJenicity T8f!llt(l)genicity**Ac~~rte** toxicity 

### llletDeated dose**to~ticit.y** Metaeolism studies Sensitization**ht~itation** 

# ...............,....,..

# ..... Microbial and algal**to~tici<tly** Telll'88trial vascular plant**to~Gicity** (e.fB-, seeal**~"' se~:~dles,**  growth inhibft!iGnl**Ac~:~te** and•chronic**to~icitty**

# to...,... (e.g., 

### fisn, twda,

mammals,**invarteb~81!8S)** 

### • Nell 

### auu1ment. e thructiiJI/ectivity •IIIIiI ftlhipta 

### • T_. ...not·in,

### the 11111 

### aaliiMl or control of the 

### tulanittel:-' 

## . 

## ' 

# CERTIFICATION ! 1certify thatto

### thebest of my knowledge and belief: 

### 1 •The company named in part I, section A, subsection 1a of tlllis notice form 

### intends to m81'11itfacture 

### « import for a commercial purpose, other than in small quantities sotely for 'ese8Jich 

### and deYelopmef'llt, 

### the substance 

### iden>tifiecll in part 

### I. section B. 2. AU information provided in 

### this notice is complete and ti'Uihtul as of 

### 1lrle ctete of 

### submission. 3. I am submitting with this 

### notice 

### aft test data in my PQSSeSSien er

**c~** 

### and a description of all other data knowm 

### to 

### « reasonably ascertainable by me as required by 

## i 720.50 of 1Mfl'remMufac:ture Notification Rule. 

## (S}(i) The company named in Part I, 

## Section A has remitted the fee specified in 40 CFR 700.45 (b). **~**

**c~** 

# • Signature 

### of authorized official 

### 0..



# 11~t'1U /J

**tt~/eu $-j~**  

# ·f9 Signature 

### of 

### agenf

# l-Ift v 

### I Date 

# Part I - GENERAL INFORMATION



# ~ SectionA - SUBMITTER IDENTIFICATION C4 

# • Merle tXJ 

### the "Confldentilll''

### box next to any

### subMction you 

### clam

### as confldemial. 1e. Person Name

### of authorized official Titte submitting 

## Peggy 

# J. Vince Dir Reg & 

## Environ Affairs notice Company ••••••• 

## Sherex Chemical Company Mailing address (number and street)



## 5777 

## Frantz Road City, State, ZIP code



## Dublin. Ohio 43017 b. Agentlif Name 

### of authorized official Titte appficable) Company 

# tr \ Mailing address lnumber and street) •••••• 

## / City, State, ZIP code 

## .< c. "you are

### submitting this 

### notice as Plll't of

### a

### joint submissifm, 

### mMt (X) this 

### box. 

# 0 2. Technical 

### Name Ttitle contact 

## Howard M. Hickman President Company 

# ;

Hickman Assoicates. Inc. Mailingaddress lnumber 

### and street) 

# •

596 

## Whitney Ave. 

# • City, State, 21P cod& I Area code I Number



## Worthinaton. Ohio 43085 lielephone : 

## 6 14 I 

## 888-6765 3. Ifyou have had: a prenoticecommunication

**~PC)** cGnCerning: this notic:e 

### and EPA Msrlt. 

### I)(IJ 

### .IX] assigned'a· PC Numbertothe notice, enter

### the IWmber if none--+ 

### 4. Ifyou havesubmitted·

### a- test-marketing exemption (TME) 8J!Piicati4m for 1he chemical Mark()(,) substance coveredby thisnotice, enter

### the TME 

### number assigflled by EPA ifnone 

## ----+ IX] 

# s. If you havesubmitted & bonafide request 

### few the chemic.t substance C0¥8I'8d by 

### M8l'lt (X) 

# !Xl this notice, enterthe bonafide request number assigned by EPA if I'IIOne 

### ----+ 

# •• Type of Notice - Matt (XI 

# 0 Manufacture 

# [[I Import FORM EPA-7710.251·12·18-IMI Page 2**~** 

## ' 

# Part I- GENERAL INFORMATION- Continued

**·~** 

## Section 

## 8- CHEMICAL IDENTITY INFORMATION Marlc (XJ the "Confident;.#"

### box neJrt to any item you claim 

### n comi<:JenNI. 

### co......-. Dither 

### ltom1 or 

### 2 u epproprlete. 

### Ce!lllll....dother ltelno. 

### r-- H 

### 8fl0ther person will submit chemical identity information for you, mal'k (XI 

### tllle box at

### the right. 

# D Co 

### Identify the name, company. and address ofthat 

### person in a

**continualio~~t** 

### sheet. 

# ... 1 •C.._ 1 

### er2 c:Mmlc.a

**~** {for definitions 

### of class 

### 1 and

### class 2

**swD&ta~~~ces,** 

### see 11rte 

### I..... IIICtlefta ......_., 

### o. Class 

### of substance - 

### Marlf. 

### (XJ 

### ri] Claas1 

# no.s2 b. Chemical name lpreferably CAS or IUPAC nomenclature) 

# Oxirane, 2,2'-[1,6-hexanediylbis(oxymethylene)bis]



# ~ CAS# 

## 16096-31-4 

# " c. 

### Moleculalr 

### formula and CAS 

### Registry 

### Number Cif known) 

# Cl2H2204



# ~ ....... 

### d. For a 

### claea 1 suD&tance, provide 

### a structural diagram. For a class

# 2substarlC8 - 

### I1IList 1Jole immediate precursor substances with their respective CAS

### Registry Numbers. 

### 121 Describe 

### the nature of the 

### reaction or process. (311Adicate the range of composition and the typicat

### composition I where appropriate). 

### (4) Provide 

### a representative 

### structural diagram (.if possible).

**~** 

# ll . ll H C---cH-CH -0-(CH ) -0-CH -CH--cH

2 2 2 6 2 2

MMk IXJ 

### this box it you

### attach a continuation sheet. FOAMEPA-7710.25112·l8-M) Page3



# .....

# Part I- GENERAL INFORMATION- Continued

**~** Section B- CHEMICAL IDENTITY INFORMATION- Centinue4 1

### 2. Polymers !For a definition of polymer, 

### see the 

### Instructions M........) a. Indicate the 

### lowe.t number-average molecular weight composition of

### the li)Oiymer you il'ftel!lclt t& l!lllal'lliJfactl.ll'e. Indica-te the ..-ximum weight percent of low molecular weight species below 

### 500 and below 

### t,OOO absolute molecllllar weight 

### <X tlhat COITipOSi1!ion. Describe the methods of measurement or 

### the bases for your estimates. 

# NA 

# 0 Mark 

### lXI this box ifyou 

### attacha 

### contimunion sheet. 

### b. You must make separateconfidentiality claims 

### for monomer orother

### react.-t idelllltlirty,

**c~ion** information, and

**residue~!** information. Mark 

### lXI the "Confidential" box nextto any item you claim as confidelilltla 

### I1l - Provide the chemical name and CAS Registry Number of each monomer orother reec:.tam used in the manufacture of 1t1e

**~.** 

### 121 - Mark 

### CXI this column if entry in column 

### 11Iisconfidential. 

### 131 - Indicate the

## trPf4* weight percent of e.:h

### monomer or other

### reactant in

### tt. pofymer. 

### 141 - Mark 

### CXI the identity column if you want a monomeror other reactant used 

### at two 

### weighot 

### percentor less to be 

### listeat as part of the polymer description on the TSCA Chemical 

### Substance Inventory. 

### (51 - Mark 

### lXI this column if entries in columns 

### (3) and 

### 14) are confidential. (6) - Indicate the maximum weight percent of each monomeror other reactant that may be present as a residual in

### tt. polymer as manufactured for commercial purposes. (7) - Mark 

### lXI this column if entry incolumn 

### 161 is confidential. Monomer or other reactant and CAS Registry Number 

### 111 c..ft. Typical Identity CeMII· Maximum ompositiorl 

### Mart {X)

# ........ residual 

### (2) 

### 131 (4) 

### (5·1 (6) 

# NA % % % 

# "' % % % % % 

### % % 

### % % 

### % 

# 0 Mark (XJ this box 

### i1 you attach a 

### continuation 

### sheet. 

### c. Provide a representative structural diagram

### ofthe polymer, if possible.



### I]_Mark lXI this box 

### i1 you att.:ha continuation sheet. FORM EPA-7710-25112-18-841 Page4 Cc 

# - -

Co 

### del

(



# '•·····
'---

## ' 

# . I· Part I- GENERAL INFORMATION -Continued I

**~** 

## SectionB - CHEMICALIDENTITY INFORMATION - CoMinued

3. IIIIPUrtta.. 

### (a, - Identity

### each impurity 

### that may 

### be reasonably 

### anticipatedto

### be Pf'esenl

# m tllle cl:lemical substance 

### as mal\'lufactured fOI' commercial purposes. Provide 

### the CAS Registry 

### Number if aveilab'e. tf 1tlef!e a,e UAkitentitied impurities, enter "unidenti4iied." 

### (b, - Estimate 

### the ..............weight percent of each impurity. 

### Hthere ..unictentitiect imp.JI!;oies, estimate their total weigl!lt perceAt. 

### i 

## ' Malclimum I Impurity 

### and CAS Registry 

### Number 

## eo.. 

## ' 1J1!811Cel'rt 

# .. tat (iiJI) 

### % X 

# " " % 

# " 

# " % 

# Ll Merle (X} 

### this box 

### ifyou attach• 

### continuation 

### sheet. 

### 4. SynonJIM - Enter any synonyms

### for the new 

### chemic* sut1stance 

### identified in 

### subsection 1 or 2. 

# c. 

# .. - X 

# D Merle (X} 

### this box 

### ifyou attach• continuation 

### sheet.



# ~ 1. Trecleldentlflcatlon - Usttrade names for

### the new chemical substance identified

# m SlllbsectiiCI)fll 

### 1 Cllt 

### 2. 

## DILUENT H 

# ' D Merle (XI 

### this box 

### ifyou attach• continuation

### sheet. 

# \1) I. Generic chemlcel....... -Ifyou claim 

### chemic* identity • 

### cGnlidential, enterthe 

### generic chemical 

### neme thatyou developed wim EPA during 

### prenotice communication. tf 

### yw have

### not developecla 

### generic 

### n.ne with EPA. Pf'OVide a generic name 

### that reveals 

### the 

### specifiC chemical identity of

### the 

### new chernic81 

### substanceto

### the 

### maximum extent possible. Read 

### the TSCA Chemical
**~8f1Celnventory,** lritiallnventory, 

### VoU'ne Ifor guidance

**on~** generic names. 

# 0 Marlc (X} 

### this box 

### if

### you

### attach• 

# continuation.,__ 7. ayproducta -Describe 

### any bypt'oducts

**~from** 

### 1he

### INIIUiac:1Ure, proc:eMilrls, lil&e, or disposal·ofthe AeW 

### cl!llmical substance 

### at sitesyou

### control. Provide

### the 

### Registry NumMr if availabte. . 

### 8yprocluct
**CAS~Number** 

### Cef 

# m (2') 

# ..... None. The Pmn

**substanQ~** 

# ia imgct:ted
0 Marlc 

### f)(' thie box

### i#youattach• 

### continuation sheet. FORM EPA-7710.25 t12·18r-84) PageS

# Part 1- GENERAL INFORMATION- Continued

**~** 

## SectionC- PRODUCTION, IMPORT, AND USE INFORMATION Mark (X) the "Confidential"

### box next to any

### item you claim liS confidential. 

### 1 • Production volume - Estimate the maximum production volume during the first 

### 12 months of production. Also estimate the maximum production volume for any consecutive 12-monthperiod duringthe first three years of production. 

# c...-

**~--------~------------~--------------~--~--~------~----~------------------------~~** ,... first 1"

**nrntf••~inn** (kg/yr) u .. ,;... ,,... 1"

**.-~. ·•~**  (kg/yr) 

### X 

### 2 U• You must make separate claims for the .....,-:

**'f~**

### •of the category of use, 

### the percent of production 

### volume delo'cMec to eac1 categoty, theformulation ofthe new substance, and other 

### use information.

# Mart'"'' the 

### "Confidential" box nextto any item you claim 

### as

**con~al.** a. 11 

### I - Describe each intended category of use 

### of

### thenew chemical substance by function and application. 121 - Mark

### lXI this column 

### if entry in column

### I1I is confidential. 13) - Estima1e the percent of total production for

### thefirst three 

### years 

### devotedto eech 

### category of use. 141 - Mark

### tXI this column if entry in column 131 

### is confidential. 151 - Estima1e the percent of the new substance as formulated in 

### mixtures, suspensions, emulsions, solutions, or gels as

**manuf~** for commercial purposes at sites under your control associated 

### whtl eech category of use. (61 - Mark

### lXI this column 

### if entry in column (51 

### is confidential. 171 - Mark 

### lXI whether 

### the use is site-limited, industrial, 

### commercial, 

## or

**C~:C~nS~Jmer.** Mark more 

### thwl 

### one coU-nn 

### if appropriate. 181 - Mark

### lXI this column if entry(ies) in column (7) is (are) confidemial. Read the 

### IMtruc:tiontl Manual for examples. Category of use 

## Reactive diluent for high performance epoxy resin systems for aerospace.



# [ J Mark IXJ 

### this_

### box ifyou 

### attacha,......; ....--..·- 

## c.... 

# .......

121 

# !i:i'

.l •••••••• b. Generic use description Hyoucfaim any categOfy 

### of use 

### OescJiptitm

**~** subeection 

### 2a as

**c~icdemiel,** e1111er a 

## .....,nc: description ofthat categoJY. Reacli1tle

# ,._••*••......., for examtJ6es of 

### genellic 1o1M

**cdesc~ijDitl-..** 

# 0 Mark IX} this boxifyou attacha continuationsheet. 

### 3 "-ant Include in thenotice a copy or reasonabte facsimile of any hazard warning statement, 

### labef, material safety data 

### sM«, Gr other informa1ion

### which wiH be provided to any person regarding protective equipment or practices 

### for the safe hanc:ling. transport, 

### use, or dispoMI of the 

### new chemical substance. List in part

### Ill any hazard information you include. 

## !i} Marie IXJ this box ifyou 

### llttachhazardinformation.i I 

# Part II- HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE



# ~ SectionA- INDUSTRIAL SITES CONTROLLED BY THE SUBMITTER CompleteMCtiGn 

### A tar

### NChtype of rMnufltCttM'e,

**~** 

### • ....opentlon 

### lnvolvllntlthe

### new cheMical Mlbatanc•

### at

### lnduatrlelaltMyou

### control. Marie 

### (XJ 

### the "Confidential" box

**~~~e~t** to any item you claim as conf'ldential. 

### 1 • Opwatlon ciMcripdon co,

•· Identity- Enter

### the identity of

### the site at which the operationwiH ox:cllllt. 

### d•nl 

### NIHIMl 

## KMI Sales£ Inc Siteaddress tnumber and street) 

# 21a Kock Street City, County, State, ZIP code 

## Pekin 

## Tazewell, Illinois 

## 61554 Ifthe same operation wiloccur at more than one site, enter 

### the

**r:~umber** of

### shes. I Identify

### the

### additional sites on a continuation sheet. I I 

# 0 Mart IXJ

### this box 

### if

### you attach a continuation sheet. 

### I b. Type- 

# liJ Manufacturing 

# 0 Pl!ocessms 

# 0 Us.e Marie 

### (X} o. Amount and Duration - Complete 

### 1 01

### 2 

### a appropriate 

### Muimum kg/batch I 1-tGuPsfibetch I Ballcl!les/year 

### 1. S.tch 

# NA I I I I Maximum kg/day I 1-tGuPs/dey I Da.ys/y-ear 

### 2. Continuous 

# NA I I I I 

### d. Proceaa description 

### (1t Diagram 

### the major unit operation steps and chemical conversions. 121 Provide the identity, 

### the approximate weight lby kg/day or kg/batch), and entry poiflllt of all feedstocks (illlcluding reactants, 

# - solvents, and catalysts). (3) Identify by numberthe points of release to the environment ofthe new chemical suiDstance. 

## The process is not know to the importer, but the product can be made by reacting the polyol with the oxirane group of the epichlorohydrin and reestablishing the oxirane group with strong caustic.

MMII 

### fXJ

### this box 

### if

### you attach a continuation sheet. 

### Page 7

# Part II- HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE- Continued

**~** 

## SectionA - INDUSTRIAL SITES CONTROLLED BY TrNE SUBMITTER - 

## Continued

2. 

### Occupetfonat

**Expot~Ut"e** - You must make separate confidentiality claims for the description of worker activity, physical fonn of 

### the new 

### chemic substance, number of workers exposed, and duration of activity. Mark (X) the "Confidential" box l'l&xt

### to any 

### item you claim 

### as confidential. 

### t1) - Describe the activities in which workers may be exposed to

### the new chemical subatance. Include activities i111 which workers wear protective equipme

**12~** 

### - Mark 

### (X) this column 

### if entry in column (

### 1) is confidential. 

### 13) - Indicatethe physical formls) ofthe new chemical substance atthe time·of exposur-e.

**14~** - Mark (X) this column if entry in column (3) is confidential. 

### 15) - Estimate the maximum number of workers involved in 

### each activity. 16) - Mark IX)

### this column 

### if entry in column (5) is confidentiaa. 

### 171 and

**(8~-** Estimatethe maximum duration ofthe activity for an.y worker in hours.perday and days per year. 19) - Mark (•X) this column 

### if entries in columns (7) and (8) 81'8 confidential. WorkM activity 11) 

## None. The imported subtance will be shipped in the original containers.



# 0 Mark 

### (X} this box 

### H

### you lfttach 

### a continuation 

### sheet. 

### c-tl- Physical Conti· ......._. form(e) ....._,

**~~ (~**  

# (. c..ft... Maxilllllwm dlllration Co



### ...... HrsJdat(

**0~/'l'r** del

(6) 17) (81) (1

3. Environnlentlll ......_

### lind DlapotNtl - You must make separate confidentiality claims for 

### the retease 

### number and the amount of

### the new chemt substance released and other release and disposal information. Mark (X) the "Confidentiat" box nextto each i:temyou claim as confidential. 

### 111 - Entet' the 

### numberof each release point identified in the process description, pan tl, sectian 

### A, subsecliiooft 

### 10(3). 121 - Estimatethe 

### amount of

### the new chemical substance reteased directly to 

### the erwil'onment or 

### into COI'IItrcllll 

### technology lin kg/day or kg/batch). 

### 13) - Mark IX)

### this column if entries in columns 

### 11) and !2) are confidential. • 141 - Identifythe media lair, land, or watM) to which 

### the new substance will be 

### l'8leasecl frOfllll 

### that

### retease poin!t. 

### 151 - Describe controltechnology, if any, that will be 

### usedto 

### limit the release of the new 

### substance

### to the erwironment. For releases disposed of on land, charactMize the disposal 

### method. 161 - Mark lXI this column if entries in columns 14) 

### a'ld !5) are confidential. 171 - Identify the destinationlsl of releases to watM.

Release Amount of new substance 

### Confl. Media 

### of Number released ........, release

(1) 

### 121 13) (4) 

## NA. Imported

17) Mark (X) the destination(&) 

# 0 POTW (publicly owned of releases 

### to watet'. treatment works) 

# 0 Mark ()() this boK

### H

### youattach a continuation 

### sheet. FORM EPA·77fQ-25 0 2·T 8-841 

# 0 Navigable waterway PageS 

# D Other - Speci(y

# .,



# ~ ' . Pan II- 

# HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE - 

# Continued i

**~** Section 

## 8 - INDUSTRIALSITES CONTROLLED BY OTHERS Complete

### MCtlen 

### 8 for 

### MCiltype

### ofproceatllntl or ...operetlon

## lnvohfnsl the

### newchetnlul

### subet8nce 8t 

### eltee you 

### do not

### control. To 

### cltlim infomtlltion 

### In this aection as 

### confidential, circle rx

### bracket

### the

# ••dflc information 

### that you cktim as confidential. Operation description Describe 

### thetypical pt'ocessii'IG or use operation. Identifythe unit

### operation steps which may occur 

### dwin; 1he 

### operation. Estimate the number of si1es at whichthe operation is likelytooccur. Identify 

### sit\.Nrtions in which worker exposure

### te and/or environmentat release of

### thenew chemical substance may occur. Estimate the percent 

### of new chemic.al substance

**as~** 

### in products manufactured!for commercial purposes inthe operation oras used 

### in the

### operation. Estimate 

### the 

### nwnber of workers exposed IM'ICit the duration 

### olexposure. Identify controls which limit worker exposure and 

### emrironmental

### release ;ttypic:aly 

### used. Identify bypt'oducts whichmay resutt 

### from the operation. 

## The PMN substance is a rective diluent for high performance epoxy compounds. It will be formulated with epoxy resins and other ingredients to make high performance resin systems intended for use in aerospace applications.



# n Mart IX) this box if

### you ettech a continuation sheet. FOAIIt'IPA-71'r0"25 (t 2·18-84) 

### Page9\ 

# Part 

# Ill- LIST OF ATTACHMENTS Attach continuation sheets for sections of the form and test data and other data (including physical/chemical properties and structure/activity informationl, and optional information afterthis page. Clearly idert11ify 

### the attachment and the section of the fonn to which it relates, 

### if appropriate. Number consecutively the pages of the attachments. 1111 

### the column below, enter the inclusive page numbers of each attachment. Mark (X) 

### the "Confidential" box next to any attachment

### nameyou claim as confidential. 

### Read the ln.wctions 

### M•nual for guidance on how to claim any information in an attachment as confidential. You must 

### include with 

### the sanitized copy ofthe notice form a sanitized version of any attachment in which you claim infonnation as confidential. Attachment name Attachment 

# c. page number(sl 

# .. C! ......... ,...,: fl'nvi l"n1 

## nt1i ca.l Data 

## 11-14 

# ... 'I'P.t!hnical Data 

## Sheet 15-17

_0 Mark IX) this 

### box ifyou 

### attach

### a continuation sheft. 

### Enter the

### attachmentnameand

### number. FORM EPA-7710.25 (12-18-841 

### Page10

## SHEREX CHEHICAL COMPANY, Inc. Mr. John D. Durig P.O. Box 646 Dublin Ohio 43017/USA Schering Akliengesellschafl



# c~ lnduslrie-Chemikalten ictr.ton tC

**:~** 07di&·1 

## IC-CP/P.-G.
**.:::;o>•r·~·2246** 

## 27. 05.88 

## Re: Reactive Diluents Dear 11r. Durig, attached you'll find a survey of toxicological data with literature sources of 

## 12 reactive diluents (phenylglycidylether is not on our sales list). The data were collected by a working group of the "Association of .Plastic Hanufacturers in Europe" (AP11E). Best regards '

# ..

Page 11

**~ostanschrift:** Schering Aktil'ngesellschaft. Postfach 15 40, 0-4709 Bergkamen

**~;.:·** 

## =·:·· _:-,:·. ;:.,,.;_:. ,,.-..· · .•1 :: .:·.

**~.·** ·.: ·
**~'-'"···-** .•

**::2~** :-:- '

.. 

## . :. 

# - .•.

### · : 

### .. 

### .

## .. . . ..

### .....,. .

**~-** . 

### . . 

## .. ...

# .. 

# .-· 

# . - 

# .

\ 

# .

# :·-



# .-..

...

-, ··-J 

# Survey of Toxic-ological Oatas withLiterature of 12 Reacti.ve Oil uents ··: RV-Worldng group of **APME~ERC-HSE~Subcommitee** 

# February 1987 

# Members: Dr. E. Albrecht, Hoechit Mr. K. Bhagwati, Dow Dr. 

# F. Kugler, Ciba-Geigy Dr. B. Meier, Bakelite Hr. 

# W. Press, Schering Dr. B. Reeve, Shell Dr. S. Schaaf, EMS Abbreviations of Reactive Oiluents CAS-No. NPGOE CGE ::GE EHGE BDDGE 

# c12

# -c 14-Alkyl-GE BPGE 

# c13

# -c 15-A1 

# kyl-GE PPODGE PGE = 

# Neopentylglykoldiglycidylether = **C~esylglycidylether** 

# = n-Butylglycidylether = 2-Ethylhexylglycidylether = Butandiol-1,4-diglycidylether =Alkyl 

# (c12

# -c 14)glycidylether
= 

# p-tert. Butylphenylglycidylether


# . ·.

_= 

# Alkyl 

# {c13

# -c 15) g lycidyl_ether



# = Polypropyleneglyco1

# diglycidylether 

# =Phenylglycidylether 17 557-23-2 

# o-: 2 210-79-9 ?f:lt'l1..:}1 

## p-: 

# 2 186-24-5 2 426-08-6 

# 2 

# 461-15-6 2 425-79-8

, 68 609-97-2 3 101-60-8 I 

# 68 081-84-5

30 401-87-7 122-60-1 - L_ = 

# Glycidylether_ of propoxylated glycerol

Datas collected by Or. S. Schaaf Pa e 12 

# Corrections and additional informationsg **---------~--------------in~ritten** 

## manner to 

# Dr .. S. Schaaf

# .. ... 

# . 

# . 

# -

A '.,., ..• 

# SUBSTANCE CAS-No··· Viscosity .· mPa-s (25°C) Vapour P.ressure(63 mbar 

# (20°C) . Solubility in (63) water g/lt LD 50 

# oral mg/kg 

## LD 

# 50 derm. ··-.. mg/kg

• • **~''·.:. --~--·**  > • '·· "'--.'

**~-** : 

# Skin **irrit~tion** 

# :.Skin sensitizati ' ·.· . ........ 

# ..._..... **-:--------~::::.:;.:;:.** 

## ·Ames-test



# -... 

### . 

# .

. •·: .-. 

## ( i 

# f! _ 

# vi t 

## ro) . : ....Cytogenetic test



# (in vivo) Carcinogenicity ( s k

## i n pa 

## i nt 

## i ng) 

# ·Reproductive .··

(dominant_letha1) Teratogenity .· 

# Classification. 

# R-Phases S-Phases 

# Paint directives 

# 30401-87-7 

# PGE 122-60-1 6 - 9 3,3 

# 2 11 

# 7 5000 (rats) 

# 3850 (25)(

# 32 )(55)(64) 

# {101) 4260 

## (57) 

# 7 5000 (rats) 

# (101)



# x. 

# .. ' 

# !agg

**~)1~~~~}~~ h>**  2160 

## (rats) (25)(58) 

# 2990 (rabbits)(55j 

# 1500 (rabbits)(57) mild to 

# moderate (32)(55){57)(61) 

# severe (32) 

## (57) 

# {58) (60) {64 ) 

# negative 65) 

## positive 

# 62 69 ( 12 

# ppm, inhalation) 

# negative (62)(69)

1 inha1ation 

## negative (26) (55)

**~4** 

## )(65) . 

# (93) 

# , 36/38, 43 

# 28(W+S), 

# 37/39 

# x. )1 

# Harmful, Xn 21 , 

# ~-2-3 **~(**

v!.-a-P .-=-)-, 

# -:-2-:-4/:-::-2-::-5.....,\ 28 (W+S), 

# 37/39 

# , :::. 

## X "1 

## 1 

# n::. Page 13

# - 35 - < 

# 92. Statement on the comparative irritating ans sensitizing potentialities of reactive diluents of teh monoepoxide

**typ~.** 

# Shell Chemical Company, November 1966 93. Terill, J.B. and Lee, K.P. The inhalation toxicity of phenylglycidyl ether: mutagenic teratogenic cytogenic and 90-days studies.

**Tox~** 

# Appl. Pharm. 37 (1) : 191, 1976 94. Stankevich, K.I. et al Hygenic characertistics of epoxy glue K-4S Vrach.Delo, (4) : 137-140, 1972 95. Shell - Internal data sheet of Dec 1986 96. Data from Proctor Gamble (Shell Internal data sheet of Dec. 1986)

...· .......... 97. Schering, Dez. 1978



# ,.-· ;



## ~-· 

# 98. Schering, Nov. 1978 99. Schering, Oct. 1979 100.

**Sche~ing,** 

# Jan. 1981 : **I~dic~tions** 

# from Proctor And Gamble Corp.

**101~** 

# Ciba Geigy Report, August 8, 1972

.. **102~'** 

# EMS INBI FO, .B' 

# Testreport A 0405/103 e 26. April 1972 103. EMS INBlFO, Testreport A 0405/013 b 20. April 1972 104. EMS INBJFO, Testreport A 0405/013 f 26. April 1972 105.· EMS INBIFO, Testrepori 

# A0405/013 d 24.April 1972 106. EMS INBlFO, Testreport A 0405/1052, 26. Feb. 1974 107. EMS INBIFO, Testreport A 0405/013 c, 24.April 1972 108. Bakelite GmbH (written statement of Or. Meier of 17. February 1987) 109. Canter, D. A. et al. Mut. Res. 172 **(1986)~.105-138** 

# (see also 70.) 110. EMS-CCR Report 101 801, February 1987 llL 

# EMS-CCR Report 101 608, February 1987 .. 112. EMS-CCR Report 101 _700, February 1987 '



# ·- ,__ -- ·113. EMS-CCR Report 102 104, February 1987 .--c _. ·



## Page 14

### Table 1: Reactive diluents for Epoxy resins

..- 

### Diluent K c 

### cresyl-glycidyl ether ., 

### aromatic p·tertiarybulylphenyl 

# .. Diluent P 

## .. ., 

### glycidyl ether Diluent A ethylhexyl·glycidyl ether mono functional Diluent B bulyl·glycidyl ether DiluentE long chain aliphatic glycidyl ether Diluenl G long chain aliphatic glycidyl

**~ther** 

### Diluent 0 butnncdtol-diglycid)•l ether aliphatic



# -~- **m:~¥~:..;;,~;~:=~:::'7.::;;,..~~-** 

# oilue"h . .

**~**

# .. **~xa~~p)igJ<trf~4'i:~2~**
**~---=~S.~!,?'ll'!'.** 

### . ..., ..,..:...,!!·· . 

### ·~~-~~·.:•···''-'""'~~··h-·•·.:·.'· ',•'



### ·~' ", 

### difunctional 

## -·---'1·',;;:..,_:.,...:,.;..;

**,,l;...,v-~;.**...**~~**........**~9-.i:'i:'"~·** 

### Diluent N neopentyl·diglycidyl ether polyoxypropylene 

# - Diluent F 

### ·" diglycidyl ether Diluenll **polyoxypropylen~**
**trifunctior;::~i** 

### triglycidyt ether


# - 

# -- Table 2 summarisesthe mosl important analytical data forthe formulator and user. Table 2: Analytic

**Ac~ctivc** dilucnls

**~-** p A B E 

### G D .. '

**~:;~-:;.;;,,**



### ~~~- N F L

**0.53-~** 57 0 43-0.47 0 49-0 53 0.7(1-0.7() 0.31-0.3G

**~** 0.32 OG;-C.76



## o:.~:ss 0.62-067

**c~.** 0.21 Cll. 0.1-l I _;-.... : 11:- ·

**s~·** 21:"1-:?33

**18~-205** 

# l ::!:Z-143 278-3:?3

**~** 313 132-,.0:5 152-'167 1·19··1G1 ca

**47~** ca 715



## .•- ·: 1!-.-.?!j :

**~~-.1 ~-**  

# i

**~· ~-1.5**  **~-15** 

### ca 1!i 

### ca :?5 ca.25 ca 20 Cll (\() ca 

### :70 I J

**v:s:~st1y** :-nr..,, s

**'2s~** C 

# -. 23 41.0 

# l !:.7 <: 0 1 

### ·, <0.1

**~ -~** 



## ~$·.~~~· 1.5 <0.1 <01

va:>ctJr oressur"! "''bar 2(f'C :; 

### ;

**~4** <It 1 <£ 1

**~2** ca.:? 1103
**,:f}!~~':'?·.'** 1!.2 

### ca. 2 ca 4

**·...rr~-·)·:l·**

### .. ':olou· va:ue

**(Ga~dncr)** 1

**~**

## :. 1.02 0.!10 0 95 0 89 0.85 1 10 

# '}:it'olr

**.~.t<"i~··.** t.OG 1.03 105 "•ash ooinl DIN 51758 ca

**1i~·** 

## c ca. tJs•c 

### ca. 93"C 

### ca. 154" C 

### ca. ISO• C ca. 160" C **·~i.J:"""·'**



## ttt~t.C. ca. 140• C ca 130" C 

### ca. 

### t.:o• c t& 40"C **~~·~7** 

### '

**-~fi~** 

# . Frasn oor:'ll DIN 53213 " "



### :o:t'~~



## Page 15·1..·

...· f 

# 1h 

# Health and safety aspects Reactive di!uents show. in comparison to the high molecular epoxy resins. a significantly higher safety risk. The primary skin irritation and sensitization caused by reactive dituents are more signilicant than with the higher molecular weight epoxy resins. Increased caution is necessary especially because reactive dituents. due to their evaporation rate and the fact that they are able to penetrate the skin also increases the risk with respect to systematic toxictty. Reactive diluents have been shown to have mutagenic effects when tested against bacteria (AMES-test). When using reactive diluents any irritations which may occur will be noticed primnrily on the skin or mucous membranes. With short chain reactive diluents (see table 9). due to the relatively high vapour pressure, an irritating clfect can be noticed in the facial area and mucous memlmmes. in addition to the skin irritating r>roporties. Prolonged exposure in rooms with inndequntP. venlilatton will lead to tedness or irritation of the fac:at and eye area. The latest results of a tongterm study of neopentytgtycot-diglycidyl·ether (Oak Ridge National Laboratory. Report ORNL 5762, June 1981). indicates that this product can be classifted as slightly carcinogenic on animal's skin underthe test conditions stated in the report. The result of this was an agreement between the Europenn manufacturers on a voluntary labelling of this product as having a harmful effect on he<::;lt with the indi· calion 'irreversible damage possible'. With this the manufacturers want to avoid possible harmful effects which could n'!sull from unqtmlified handling of the product. When utilizing reactivo t1iluents or reactive diluen't modified epoxy resins. it is

**nece!:.::~ry** 

### to consult the pampt.!et 111\023 (Polyester and Epoxy resins) olthe Berufs· genosscnschalt der Chemischen tndustrie. Further we would like to point out that our brochure 'H:nts on Toxicology and Safe Handling - Epoxy Resins/Curing Agents' and the tnforrna:ion contatned in the satety data sheets contain information on the correct handling and use of tnese products. This information shows that sale handling ol these products is possible i! 

### skin contact and inhalation of the product is avotded by the use of aprropriate skm protection, safety clothing and adequate ventilation of the work area.



## Page 16

## "' "

**~Table** 

### 9: Health and Safety Evaluation

**~** Product Ct.em. L050ora• Skm Compatibility St!nSrhzahon Vapour Markmg accordm!;: Name Identity 

### rnglkg reel Compatibility to mucous pressure to "Dangerous memhranes 

## 20•c mbar Goods Act. (Oc:. 861"' EC Guidehnes 

# -- Diluent K Cresyl· >2000 On smgle contact No •rritation Sensitizer 2.0 '"Xi'" glycrdyl· moderate. repeated R:36;43 ether contact moderate 5.26;28 to stronger irrilation DiluentP P.tert. > 10000 Can lead to very Can cause Can act as 2.3 Butyl· modcmlc trruation irntation sensitizer phenyl. on longer exposure gtvcidyl· ether Diluent A Ethyl· > 7500 Can lead to Eve rrntauon Sensilizer 4,0 hexyl· irutalrnn on longer possible glyCtdyt· exposure ether DiluentB Butyl· >2000 On singll• contar.t No rmlahon Sensitizer 5.7 "Xn" glycrdyl· moderatu. rope.11cd 

### A- 10; 

### 20; 43

**e111~r** contact moderate S: 24125 to :>tronger trrllahon Diluent E Longc:::Jin > 10000 Can lead to very No irritattori Sensitizer 

### < 0.1

--

**·~-·-··** aliphahc shght itritatron GI)•Cidyl· alter extended ether exposure Diluent G Longcllain 

### > 1000(1 Can lead to very Cnnact as .::0.1 aliphatic slight irritahon c;,1nsitizet

**Gtycidyl~.** alter extended ether exposure

•· Diluent D 1.4-Butan· 3000 On singi-:J contact Onsrnute Can act as 1.3 "Xn" diol· moderate rrntation contact sensitizer R: 20/21; 3GI38: .: 3 dig!ycidyl· modmale S: 26; 28; 37/3£- etller tmtatron ·--·-: ·.:·;"':---._,·

**--~** 

### ..

**'~-** . .,..,. ·-··.

**~** ,. ..... ,.

# ...

**--~.** ·. 

# ...



# ?~tr~i

# ·.·

**.··~IIPd' ~§jj!)gli,~QP~~lJ..~.**  .. 

# ~.~ii_,·alt-~·· **"c.~n~~~~ ~~-:1** .•



### 0_~-~-. . , 

# . . 

### iiJ:i~?Ca.f!-diok · . · . . 

### .....

**:::-=::;..,:'1.~'t..,.~~.;~,:.~;1?~----**

**~-:** .! ;:'digi)•Ctd . '

**-;:moderate·~· repeated~**  **~poss•bl** .· sens•t1zer::wr!'.•



## -~~1~~~~:i~~- **~:-~-~-;~-,~~::** .
**.:;;·.:~~--** 

### ..
**."il~JI~** '<ether'::;;"· . 

### o;r.""":

**,_.coritacl'moderari~" :1:d.$.~"f).;t:""Q**  .;f . ..:;

**·-~·**.. **:.~.;:.,;:-:;;.\~~·i~~·** ..

**;!'(.-.:·_~**

**~-.** -

### .. . ...._>.



### ~. **:~** ..·: •'



### ,~_:··: . 

### --~0-~~~·-· '·to'sfroriger

## irri:ali0n°

**~r:r;:::~~r~~~~l:- .::-:"!~~'-~:-=~~~~--**  

### ..

**·-1:-~h~** ...**~~.u..'\~·u:":";::'f'·** ..

**-:.:7'~-:w.~~~---** .....

**.~...-·::·~~~-~·-:: ~~";-~'<'** ..

**~-** . ·-··.c.;·:. Diluent N Nccnentvi- 

### > 2000 Cii" i!CI ill' 

# I G::-

**'~=~ a~**  Can ilC!

**a~:>** 

### 1.5 ">;n·· ol·l•.OI· n·net!'l! ,... ;:!

**.,~** Sf!r151tl:!f.:• R·

**:~0:2** 1; 3(\

**'3~** '"P'>'c•dy:- 

# I ·<0: 43 ether 

# ''., S: 23: 28:

**37/3~** DiluentF PolyO:r.)'· >4000 Can lead to Ca·• cause pam. Can ac1 as -:: 0.1

**pro::>~·lene·,.** rn!:!dcratc •rrr:atoor. •rrota:•on and sensitizer d•pi)'Ctdyl·

**er~·oamagc** ether DiluentL Potyo:r.y· 7400 Moderate

**~rritat•on** V<:ry moderate No irritatron <0.1 propylene· 1rr;1a:•on trigtycidyl· e;ner 

## Page 17 

# 1'7