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EXHIBIT 12.1

|                                   |                       |                                                                                                    |          |                                           |          |      |          |         |          |      |          |          |          |   |         |         |         |   |         |         |         |  
|---------------------------------- | --------------------- | -------------------------------------------------------------------------------------------------- | -------- | ----------------------------------------- | -------- | ---- | -------- | ------- | -------- | ---- | -------- | -------- | -------- | - | ------- | ------- | ------- | - | ------- | ------- | ------- | -
|                                   |                       |                                                                                                    |          | Ratio of Earnings to Fixed Charges        |         
|                                   |                       |                                                                                                    |          | (dollars in thousands, except ratio data) |         
|                                   |                       |                                                                                                    |          |                                           |         
|                                   |                       |                                                                                                    |          |                                           |         
|                                   |                       |                                                                                                    |          | Year Ended December 31,                   |         
|                                   |                       |                                                                                                    |          |                                           |         
|                                   |                       |                                                                                                    |          | 2002                                      |          | 2001 |          | 2000    |          | 1999 |          | 1998    
|                                   |                       |                                                                                                    |          |                                           |          |      |          |         |          |      |          |         
|Fixed Charges:                     |                       |                                                                                                    |          |                                           |          |      |          |         |          |      |          |          |          |   |         |         |         |   |         |        
|                                  
|                                  
|                                  
|                                  
|                                   |                       | Interest expense on
indebtedness(including
amortization of debt
expense and discount)              |          | $                                         | 23,746   |      |          | $       | 24,638   |      |          | $        | 22,088   |   |         | $       | 4,330   |   |         | $       | 207     |  
|                                  
|                                  
|                                  
|                                  
|                                   |                       | Interest expense on
portion of rent
expense
representative
of interest                             |          |                                           | 7,206    |      |          |         | 6,159    |      |          |          | 3,251    |   |         |         | 2,951   |   |         |         | 1,299   |  
|                                   |                       |                                                                                                    |          |                                           |          |      |          |         |          |      |          |          |          |   |         |         |         |   |         |        
|                                   | Total Fixed Charges   |                                                                                                    | $        | 30,952                                    |          |      | $        | 30,797  |          |      | $        | 25,339   |          |   | $       | 7,281   |         |   | $       | 1,506   |        
|                                   |                       |                                                                                                    |          |                                           |          |      |          |         |          |      |          |          |          |   |         |         |         |   |         |        
|Earnings (Loss):                   |                       |                                                                                                    |          |                                           |          |      |          |         |          |      |          |          |          |   |         |         |         |   |         |        
|                                  
|                                  
|                                  
|                                  
|                                   |                       | Net loss before
provision for income
taxes and cumulative
effect of change in
accounting principle |          | $                                         | (219,716 | )    |          | $       | (117,152 | )    |          | $        | (235,331 | ) |         | $       | (41,944 | ) |         | $       | (22,957 | )
|                                  
|                                  
|                                  
|                                  
|                                   |                       | Fixed Charges per above                                                                            |          |                                           | 30,952   |      |          |         | 30,797   |      |          |          | 25,339   |   |         |         | 7,281   |   |         |         | 1,506   |  
|                                   |                       |                                                                                                    |          |                                           |          |      |          |         |          |      |          |          |          |   |         |         |         |   |         |        
|                                   | Total Earnings (Loss) |                                                                                                    | $        | (188,764                                  | )        |      | $        | (86,355 | )        |      | $        | (209,992 | )        |   | $       | (34,663 | )       |   | $       | (21,451 | )      
|                                   |                       |                                                                                                    |          |                                           |          |      |          |         |          |      |          |          |          |   |         |         |         |   |         |        
|Ratio of Earnings to
Fixed Charges |                       |                                                                                                    |         |                                           |          |      |         |         |          |      |         |          |          |   |        |         |         |   |        |        
|                                  
|                                  
|                                  
|                                  
|Coverage deficiency (1)(2)(3)      |                       | $                                                                                                  | (219,716 | )                                         |          | $    | (117,152 | )       |          | $    | (235,331 | )        |          | $ | (41,944 | )       |         | $ | (22,957 | )      
|                                   |                       |                                                                                                    |          |                                           |          |      |          |         |          |      |          |          |          |   |         |         |         |   |         |        



|(1) |  | The Companys Coverage deficiency for 2002 includes charges aggregating
$46,396 arising from the Companys impairment charge relating to its
investment in CAT and a charge for construction design changes of $32,158
and $14,238, respectively.
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|(2) |  | The Companys Coverage deficiency for 2001 includes charges aggregating
$26,208 arising from the Companys impairment charge relating to its
investment in Transgene and debt conversion expenses of $22,314 and $3,894,
respectively.           
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|   
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|(3) |  | The Companys Coverage deficiency for 2000 includes charges aggregating
$184,868 arising from purchased in-process research and development and debt
conversion expenses of $134,050 and $50,818, respectively.