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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Form 10-K



|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the Year Ended December 31, 2010

OR

| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

Commission File Number 000-51531

SUNESIS PHARMACEUTICALS, INC.

(Exact name of registrant as specified
in its charter)



|                                                                        |  |                                                   
|----------------------------------------------------------------------- |  | --------------------------------------------------
|Delaware (State or other jurisdiction of incorporation or organization) |  | 94-3295878 (I.R.S. Employer Identification Number)

395 Oyster Point
Boulevard, Suite 400

South San Francisco, California 94080

(Address of principal executive offices, including zip code)

(650) 266-3500

(Registrants telephone number, including area
code)

Securities registered pursuant to Section 12(b) of the Act:



|                                          |  |                                           
|----------------------------------------- |  | ------------------------------------------
|Title of Each Class:                      |  | Name of Each Exchange on Which
Registered:
|Common Stock, par value $0.0001 per share |  | The NASDAQ Stock Market LLC               

Securities registered pursuant to Section 12(g) of the Act:

None

(Title of Class)

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes  ̈ No x

Indicate by check mark if the registrant is not required to file reports pursuant
to Section 13 or Section 15(d) of the Act. Yes  ̈ No x

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the
Securities Exchange Act of 1934 during the preceding 12 months (or for such period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes x No  ̈

Indicate by check mark
if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated by
reference in Part III of this Form 10-K or any amendment to this Form 10-K.  ̈

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule
405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes  ̈ No  ̈

Indicate by check mark whether the registrant is a large accelerated filer,
accelerated filer, a non-accelerated filer or a smaller reporting company. See definitions of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the Exchange Act. (Check
one):

|                          |  |                     |  |                                                                     |  |  |                             | 
|------------------------- |  | ------------------- |  | ------------------------------------------------------------------- |  |  | --------------------------- | 
|Large accelerated filer  ̈ |  | Accelerated filer  ̈ |  | Non-accelerated filer  ̈(Do not check if a smaller reportingcompany) |  |  | Smaller reporting company x | 

Indicate by check mark whether the registrant is a shell company (as defined in Exchange Act Rule 12b-2.) Yes  ̈ No x

The aggregate market value of common stock held by non-affiliates of the
registrant, based on the closing sales price for such stock on June 30, 2010, as reported by The Nasdaq Stock Market, was $63,430,697. The calculation of the aggregate market value of voting and non-voting stock excludes 14,369,372 shares of
the registrants common stock held by current executive officers, directors and stockholders that the registrant has concluded are affiliates of the registrant. Exclusion of such shares should not be construed to indicate that any such person
possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the registrant or that such person is controlled by or under common control with the registrant.

The total number of shares outstanding of the registrants common stock, $0.0001 par value per share, as of March 15, 2011, was
46,027,474.

DOCUMENTS INCORPORATED BY REFERENCE

Portions of the registrants Definitive Proxy Statement, to be filed with the Securities and Exchange Commission pursuant to
Regulation 14A in connection with the 2011 Annual Meeting of Stockholders of Sunesis Pharmaceuticals, Inc. (hereinafter referred to as Proxy Statement) are incorporated by reference in Part III of this report. Such Proxy
Statement will be filed with the Securities and Exchange Commission not later than 120 days after the conclusion of the registrants year ended December 31, 2010.









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SUNESIS PHARMACEUTICALS, INC.



|         |  |                                                                                                              |  |         |    | 
|-------- |  | ------------------------------------------------------------------------------------------------------------ |  | ------- | -- | 
|         |  |                                                                                                              |  | PageNo. |   
|PART I   | 
|ITEM 1.  |  | Business                                                                                                     |  |         | 3  | 
|ITEM 1A. |  | Risk Factors                                                                                                 |  |         | 17 | 
|ITEM 1B. |  | Unresolved Staff Comments                                                                                    |  |         | 34 | 
|ITEM 2.  |  | Properties                                                                                                   |  |         | 34 | 
|ITEM 3.  |  | Legal Proceedings                                                                                            |  |         | 34 | 
|ITEM 4.  |  | (Removed and reserved)                                                                                       |  |         | 34 | 
|        
|PART II  | 
|ITEM 5.  |  | Market For Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities |  |         | 35 | 
|ITEM 6.  |  | Selected Financial Data                                                                                      |  |         | 36 | 
|ITEM 7.  |  | Managements Discussion and Analysis of Financial Condition and Results of
Operations                        |  |         | 38 | 
|ITEM 7A. |  | Quantitative and Qualitative Disclosures About Market Risk                                                   |  |         | 48 | 
|ITEM 8.  |  | Financial Statements and Supplementary Data                                                                  |  |         | 49 | 
|ITEM 9.  |  | Changes in and Disagreements With Accountants on Accounting and Financial
Disclosure                         |  |         | 73 | 
|ITEM 9A. |  | Controls and Procedures                                                                                      |  |         | 73 | 
|ITEM 9B. |  | Other Information                                                                                            |  |         | 74 | 
|        
|PART III | 
|ITEM 10. |  | Directors, Executive Officers and Corporate Governance                                                       |  |         | 75 | 
|ITEM 11. |  | Executive Compensation                                                                                       |  |         | 75 | 
|ITEM 12. |  | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder
Matters               |  |         | 75 | 
|ITEM 13. |  | Certain Relationships and Related Transactions, and Director Independence                                    |  |         | 76 | 
|ITEM 14. |  | Principal Accounting Fees and Services                                                                       |  |         | 76 | 
|        
|PART IV  | 
|ITEM 15. |  | Exhibits, Financial Statement Schedules                                                                      |  |         | 77 | 
|         |  | Signatures                                                                                                   |  |         | 78 | 
|         |  | Exhibit Index                                                                                                |  |         | 79 | 



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PART I

SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

This report,
including the information we incorporate by reference, contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as
amended, that involve risks, uncertainties and assumptions. All statements, other than statements of historical facts, are forward-looking statements for purposes of these provisions, including without limitation any statements relating
to our strategy, including our plans with respect to presenting clinical data and initiating clinical trials, our future research and development activities, including clinical testing and the costs and timing thereof, sufficiency of our cash
resources, our ability to raise additional funding when needed, any statements concerning anticipated regulatory activities or licensing or collaborative arrangements, our research and development and other expenses, our operations and legal
risks, and any statement of assumptions underlying any of the foregoing. In some cases, forward-looking statements can be identified by the use of terminology such as anticipates, believe, continue,
estimates, expects, intend, look forward, may, could, seeks, plans, potential, or will or the negative thereof or other
comparable terminology. Although we believe that the expectations reflected in the forward-looking statements contained herein are reasonable, there can be no assurance that such expectations or any of the forward-looking statements will prove to be
correct, and actual results could differ materially from those projected or assumed in the forward-looking statements. Our actual results may differ materially from those anticipated in these forward-looking statements as a result of many factors,
including but not limited to those set forth under Risk Factors, and elsewhere in this report. We urge you not to place undue reliance on these forward-looking statements, which speak only as of the date of this report. All
forward-looking statements included in this report are based on information available to us on the date of this report, and we assume no obligation to update any forward-looking statements contained in this report.

In this report, Sunesis, the Company, we, us, and our refer to Sunesis
Pharmaceuticals, Inc. and its wholly owned subsidiary, Sunesis Europe Limited, except where it is made clear that the term refers only to the parent company.



|ITEM 1. | BUSINESS
|------- | --------

General

We are a
biopharmaceutical company focused on the development and commercialization of new oncology therapeutics for the treatment of hematologic and solid tumor cancers. Our efforts are currently focused primarily on the development of vosaroxin (formerly
voreloxin) for the treatment of acute myeloid leukemia, or AML. We have built a highly experienced cancer drug development organization committed to advancing our lead product candidate, vosaroxin, in multiple indications to improve the lives of
people with cancer.

Vosaroxin is a first-in-class anti-cancer quinolone derivative, or AQDa class of compounds
that has not been used previously for the treatment of cancer. Quinolone derivatives have been shown to mediate anti-tumor activity by targeting mammalian topoisomerase II, an enzyme critical for cell replication. We own the worldwide development
and commercialization rights to vosaroxin.

In December 2010, we commenced enrollment of a Phase 3, multi-national,
randomized, double-blind, placebo-controlled, pivotal trial of vosaroxin in combination with cytarabine in patients with relapsed or refractory AML, or the VALOR trial. The VALOR trial is designed to evaluate the effect of vosaroxin in combination
with cytarabine, a widely used chemotherapy in AML, on overall survival as compared to placebo in combination with cytarabine. The trial design is based on data from our Phase 2 clinical trial of vosaroxin in combination with cytarabine in first
relapsed or primary refractory AML, together with guidance received from both U.S. and European regulatory agencies.



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With an anticipated 450 evaluable patients, the trial is designed to have a 90% probability
of detecting a 40% difference in overall survival. The trial includes a single pre-specified interim analysis by the independent Data Safety Monitoring Board, or DSMB, that may recommend a one-time sample size adjustment of 225 additional evaluable
patients if deemed beneficial by the DSMB to maintain adequate power across a range of clinically meaningful and statistically significant survival outcomes. In February 2011, the FDA granted fast track designation to vosaroxin for the potential
treatment of relapsed or refractory AML in combination with cytarabine.

We are also in the survival follow-up stage of two
fully-enrolled clinical trials of vosaroxin: (a) the Phase 2 portion of a Phase 1b/2 trial of vosaroxin in combination with cytarabine for the treatment of patients with first relapsed or primary refractory AML, and (b) a Phase 2
trial (known as REVEAL-1) in previously untreated elderly patients with AML, which explored three different dose schedules. In addition, we completed a Phase 2 single agent trial of vosaroxin in platinum-resistant ovarian cancer patients in 2010,
which explored three different dose cohorts. The most recent data from the AML studies were presented at the Chemotherapy Foundation Symposium XXVIII in November 2010, and the most recent data from the ovarian cancer study were presented at the
American Society of Clinical Oncology 2010 Annual Meeting in June 2010.

In 2009, the U.S. Food and Drug Administration, or
FDA, granted orphan drug designation to vosaroxin for the treatment of AML. In July 2010, we announced that the European Patent Office, or EPO, had granted us a patent covering combinations of vosaroxin with cytarabine. The patent provides coverage
to 2025 for such combination products in 30 member states of the European Patent Convention. In November 2010, we announced that the U.S. Patent and Trademark Office had granted us a patent covering pharmaceutical compositions of vosaroxin, and in
March 2011, we announced that the EPO had granted us a similar patent, which we are proceeding to validate in multiple EPO member states. These patents cover the formulation used in our VALOR trial and extend vosaroxins patent life to 2025.
Related patent applications are pending in other major markets throughout the world, including Japan, Australia and Canada.

Vosaroxin

Vosaroxin is a first-in-class AQDa class of compounds that has not been used previously for the treatment of
cancer. Quinolone derivatives have been shown to mediate anti-tumor activity by targeting mammalian topoisomerase II, an enzyme critical for cell replication. Vosaroxin acts by DNA intercalation and inhibition of topoisomerase II in replicating
cancer cells. The resulting site-selective DNA damage rapidly causes the cancer cells to stop dividing and die. In preclinical studies, vosaroxin demonstrated broad anti-tumor activity and appears to exhibit additive or synergistic activity when
combined with several therapeutic agents currently used in the treatment of cancer, including cytarabine. Clinical activity is observed in both solid and hematologic malignancies. We licensed worldwide development and commercialization rights
to vosaroxin from Dainippon Sumitomo Pharma Co., Ltd. in 2003.



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Acute Myeloid Leukemia

The following chart summarizes the status of clinical trials in AML that have been conducted or are currently being conducted with
vosaroxin:

LOGO

Since 2004, we have initiated eight clinical trials with vosaroxin. A Phase 1 clinical trial was
conducted to evaluate two dosing schedules of vosaroxin in patients with advanced solid tumors. A further Phase 1 clinical trial was conducted to evaluate doses and schedules of administration of vosaroxin in patients with relapsed/refractory acute
leukemia. We also conducted two Phase 2 studies in non-small cell lung cancer and small cell lung cancer. Partial responses were observed in both lung cancer studies, but it was determined that vosaroxin could be dosed with greater intensity
given the low incidence of grade 3/4 neutropenia (15% or less). Thus, the studies were halted and we may consider future vosaroxin studies in lung cancer or in other solid tumors and hematologic malignancies.

In December 2010, we commenced enrollment of the VALOR trial, a Phase 3, randomized, double-blind, placebo-controlled, pivotal clinical
trial of vosaroxin in combination with cytarabine in patients with relapsed or refractory AML. The VALOR trial is designed to evaluate the effect of vosaroxin in combination with cytarabine, a widely used chemotherapy in AML, on overall survival as
compared to placebo in combination with cytarabine. The trial design is based on data from our Phase 2 clinical trial of vosaroxin in combination with cytarabine in first relapsed or primary refractory AML, together with guidance received from both
U.S. and European regulatory agencies. The trial is expected to enroll 450 evaluable patients at approximately 100 leading sites in the U.S., Canada, Europe, Australia and New Zealand, and is designed to have a 90% probability of detecting a 40%
difference in overall survival. The trial includes a single pre-specified interim analysis by the independent DSMB, which may recommend a one-time sample size adjustment of 225 additional evaluable patients if deemed beneficial by the DSMB to
maintain adequate power across a range of clinically meaningful and statistically significant survival outcomes.



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In January 2010, we completed enrollment in the Phase 2 portion of a Phase 1b/2 clinical
trial of vosaroxin in combination with cytarabine for the treatment of patients with relapsed/refractory AML. The trial is designed to evaluate the safety, pharmacokinetics and anti-leukemic activity of escalating doses of vosaroxin when
administered in combination with cytarabine given either as continuous infusion or as a two hour IV infusion. A total of 69 patients were evaluable for efficacy outcomes in the expansion Phase 2 populations of the trial, which includes primary
refractory and first relapsed AML patients. Among evaluable first relapsed (n=36) and primary refractory patients (n=33), median overall survival was 7.1 months and the combined complete remission rate (including complete remissions, or CR, complete
remissions without full platelet recovery, or CRp, and complete remissions with incomplete recovery, or CRi) was 29%, with a CR rate of 25%. Vosaroxin in combination with either bolus or continuous infusion cytarabine was generally well-tolerated.
Infection-related toxicities were the most common Grade 3 or higher non-hematologic adverse events. In addition, Grade 3 or higher oral mucositis was observed in 16% of the population and was manageable. All-cause mortality among these patients was
3% at 30 days and 9% at 60 days. Preliminary median leukemia-free survival is 14.4 months and 22% of the patients in the Phase 2 portion received hematopoietic stem cell transplants. This data was presented at the Chemotherapy Foundation Symposium
XXVIII in November 2010.

In October 2009, we completed enrollment in a Phase 2 single agent clinical
trial of vosaroxin in previously untreated elderly AML patients. The trial includes three dosing schedules: Schedule A, once weekly for three weeks (n=29); Schedule B, once weekly for two weeks (n=35); and Schedule C, on days one and four at either
72 mg/m2(n=29) or 90 mg/m2(n=20). Median survival was 8.6 months in Schedule A, 5.7 months in
Schedule B, and 7.7 months in Schedule C (72 mg/m2). One
year survival was 38% for Schedule A, 32% in Schedule B, and 38% in Schedule C (72 mg/m2). Based on trial results, Schedule C (72 mg/m2) was determined to be the recommended pivotal dose regimen. For Schedule C, the CR plus CRp rate was 38%; 30-day all-cause mortality was 7%. This data was presented at the Chemotherapy Foundation
Symposium XXVIII in November 2010.

Ovarian Cancer

In mid-2010, we completed a Phase 2 single agent trial of vosaroxin in platinum-resistant ovarian cancer. Three dose
cohorts of vosaroxin were studied: Cohort A, 48 mg/m2given every three weeks (n=65), Cohort B, 60 mg/m2given
every four weeks (n=37) and Cohort C, 75 mg/m2given every
four weeks (n=35). Data from this trial show encouraging durable anti-tumor activity across all three dose cohorts. The overall response rate, or ORR, was 11% for Cohorts A and B, and 9% for Cohort C. Disease control, defined as an objective
response or stable disease for 12 weeks or more, was similar across the cohorts: 48% for Cohort A, 54% for Cohort B, and 57% for Cohort C. The median progression free survival, or PFS, for Cohort A was 83 days, for Cohort B was 85 days, and for
cohort C was 110 days. Overall PFS was longer in Cohort C as compared to Cohorts A and B, suggesting a benefit to higher vosaroxin doses; however, this cohort had a higher incidence of febrile neutropenia (29%) than Cohorts A (9%) or B
(5%). Based on activity and tolerability, the dose/schedule represented by Cohort B was selected for future consideration. Four partial responses were achieved in the 44 women who were Doxil® failures, for an ORR of 9%, and 66% achieved disease control. The median PFS in these Doxil® failure patients was 91 days. PFS was not statistically different from those who had not failed Doxil®. Overall, the adverse event profile was similar across cohorts and vosaroxin was generally well-tolerated. Grade 3 or higher adverse events occurring in more than 10%
of patients included neutropenia, febrile neutropenia, fatigue, and anemia. This data was presented at the American Society of Clinical Oncology 2010 Annual Meeting in June 2010.

Dainippon Sumitomo Pharma Co., Ltd. Licensing Agreement

In October 2003, we entered into an agreement with Dainippon Sumitomo Pharma Co., Ltd., or Dainippon, to acquire exclusive worldwide
development and marketing rights for our lead anti-cancer product candidate, vosaroxin. In January 2011, we made a $0.5 million milestone payment to Dainippon as a result of the initiation of our VALOR trial in December 2010. In the future we may be
required to make additional milestone payments of up to $7.0 million to Dainippon, for (a) filing new drug applications, or NDAs, in the United States,



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Europe and Japan, and (b) for receiving regulatory approvals in these regions, for cancer-related indications. If vosaroxin is approved for a non-cancer indication, an additional milestone
payment becomes payable to Dainippon.

The agreement also provides for royalty payments to Dainippon at rates that are based
on total annual net sales. Under the agreement, we may reduce our royalty payments to Dainippon if a third party markets a competitive product and we must pay royalties for third-party intellectual property rights necessary to commercialize
vosaroxin. Royalty obligations under the agreement continue on a country-by-country and product-by-product basis until the later of the date on which no valid patent claims relating to a product exist or 10 years from the date of the first sale
of the product.

If we discontinue seeking regulatory approval and/or the sale of the product in a region, we are required to
return to Dainippon its rights to the product in that region. The agreement may be terminated by either party for the other partys uncured breach or bankruptcy.

Strategic Collaborations

Overview

Over the past three years, we have generated revenue primarily through collaborations with Biogen Idec, Johnson & Johnson
Pharmaceutical Research & Development LLC, or J&JPRD, and Merck & Co., Inc., or Merck, consisting principally of research funding and milestones paid by our collaborators, which substantially offset the related research and
development expenses. Our collaborations with J&JPRD and Merck terminated in January 2010 and June 2010, respectively. From January 1, 2008 to December 31, 2010, we recorded an aggregate of $6.5 million in revenues from our
collaboration partners. In 2008 and 2009, we received $4.3 million and $1.5 million, respectively, from Biogen Idec, which represented 80% and 40% of our total revenues for these periods. In 2010, we recorded no revenue related to Biogen
Idec.

Biogen Idec

In August 2004, we entered into a collaboration agreement with Biogen Idec to discover, develop and commercialize small molecule inhibitors of Raf kinase and up to five additional targets that play a role
in oncology and immunology indications or in the regulation of the human immune system. Concurrent with the signing of the agreement, Biogen Idec paid a $7.0 million upfront technology access fee and made a $14.0 million equity investment in
Sunesis through the purchase of our Series C-2 preferred stock, which converted into common stock upon our initial public offering in September 2005.

Pursuant to the terms of the collaboration agreement, we applied our fragment-based drug discovery technology, Tethering, to generate small molecule leads during the research term, for which we received
research funding, which was paid in advance to support some of our scientific personnel. In connection with our June 2008 restructuring, the parties agreed to terminate the research term and related funding as of June 30, 2008. A total of
$20.0 million of research funding was received through this date. We have received a total of $3.0 million in milestone payments for meeting certain preclinical milestones through December 31, 2010, including a $1.5 million milestone
received in cash in July 2009 for Biogen Idecs selection of a Raf kinase inhibitor development candidate for the treatment of cancer.

We may in the future receive pre-commercialization milestone payments of up to $60.5 million per target, as well as royalty payments depending on product sales. Potential total royalty payments may
be increased if we exercise our option to co-develop and co-promote product candidates for up to two targets worldwide (excluding Japan) and may be reduced if Biogen Idec is required to in-license additional intellectual property related to certain
technology jointly developed under the collaboration agreement in order to commercialize a collaboration product.



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In November 2010, Biogen Idec announced that it will seek to spin out or outlicense certain
oncology assets, including programs under this collaboration agreement. We cannot predict the outcome of this strategic decision by Biogen Idec or its impact on future development activity under the collaboration agreement or on our prospects
for the receipt of milestone or royalty payments under the collaboration agreement. We expect that a Phase 1 clinical trial will be initiated in 2011 for the Raf kinase inhibitor program.

Manufacturing

We do not have internal manufacturing capabilities for the
production of clinical or commercial quantities of vosaroxin. To date, we have relied on, and we expect to continue to rely on, a limited number of third-party contract manufacturers for the production of clinical and commercial quantities of the
vosaroxin active pharmaceutical ingredient, or API, the finished drug product incorporating the API, or FDP, and the placebo used in the VALOR trial. We do not have commercial supply agreements with any of these third parties, and our agreements
with these parties may include provisions that allow for termination at will by either party following a relatively short notice period.

We currently rely on two contract manufacturers for the vosaroxin API, which is manufactured through a multi-step convergent synthesis in which two intermediates are manufactured in a parallel process and
then combined and de-protected in the final two steps. We recently started working with the second vosaroxin API manufacturer, and to date no vosaroxin FDP has been formulated from the vosaroxin API supplied by this second manufacturer. We also
currently rely on a single contract manufacturer to formulate the vosaroxin API and fill and finish vials of the vosaroxin FDP.

Because the vosaroxin API is classified as a cytotoxic substance, the number of available manufacturers for the API and FDP is limited.
We believe that there are at least five contract manufacturers with suitable facilities in North America to manufacture the vosaroxin API, and at least four with suitable facilities for the manufacture of vosaroxin FDP. There are also a number of
manufacturers with suitable facilities outside of North America, including one of our vosaroxin API manufacturers. If we are unable to obtain sufficient quantities of the vosaroxin API and FDP from our current manufacturers, it may take time to
engage alternative manufacturers, which could delay the development of and impair our ability to commercialize vosaroxin.

To
date, vosaroxin has been manufactured in quantities appropriate for preclinical studies and clinical trials. New lots of vosaroxin API and FDP will need to be manufactured and released to support our current and planned clinical activities,
including the VALOR trial and stability assessments required for regulatory approval. Prior to being approved for commercial sale, we will seek to arrange for the manufacture of vosaroxin API and FDP in larger quantities. Any significant scale-up of
manufacturing will be accompanied by process validation studies, which are required to be reviewed by the FDA prior to regulatory approval.

In addition, the cytarabine used in our VALOR trial is procured from third party distributors. Cytarabine is currently in short supply, but to date we have been able to procure necessary supplies to
support our VALOR trial. Additional procurement of cytarabine will be necessary to complete the VALOR trial.

Competition

We face significant competition from many pharmaceutical, biopharmaceutical and biotechnology companies that are researching, developing
and marketing products designed to address the treatment of cancer, including AML. Many of our competitors have significantly greater financial, manufacturing, marketing and drug-development resources than we do. Large pharmaceutical companies
in particular have extensive experience in the clinical testing of, obtaining regulatory approvals for, and marketing drugs.

Vosaroxin is a small molecule therapeutic that will compete with other drugs and therapies that currently exist or are being developed
for the treatment of cancer. Some of the current key competitors to vosaroxin in



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AML include Genzyme Corporations clofarabine and Celgene Corporations azacitidine. We expect competition for vosaroxin for the treatment of AML to increase as additional products are
developed and approved in various patient populations.

We believe that our ability to successfully compete in the marketplace
with vosaroxin and any future product candidates, if any, will depend on, among other things:



| |  |  | our ability to develop novel compounds with attractive pharmaceutical properties and to secure, protect and maintain intellectual property rights based
on our innovations;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the efficacy, safety and reliability of our product candidates;
| | - |  | ---------------------------------------------------------------



| |  |  | the speed at which we develop our product candidates;
| | - |  | -----------------------------------------------------



| |  |  | our ability to design and successfully execute appropriate clinical trials;
| | - |  | ---------------------------------------------------------------------------



| |  |  | our ability to maintain a good relationship with regulatory authorities;
| | - |  | ------------------------------------------------------------------------



| |  |  | our ability to obtain, and the timing and scope of, regulatory approvals;
| | - |  | -------------------------------------------------------------------------



| |  |  | our ability to manufacture and sell commercial quantities of future products to the market; and
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | acceptance of future products by physicians and other healthcare providers.
| | - |  | ---------------------------------------------------------------------------

Intellectual Property

We believe that patent protection is crucial to our
business and that our future success depends in part on our ability to obtain patents protecting vosaroxin or future drug candidates, if any. Historically we have patented a wide range of technology, inventions and improvements related to our
business, but which we are no longer actively developing.

The vosaroxin composition of matter is covered by U.S. patent
5,817,669 and its counterpart patents in 43 foreign jurisdictions. U.S. patent 5,817,669 is due to expire in October 2015, and most of its foreign counterparts are due to expire in June 2015. In July 2010, we announced that the European Patent
Office, or EPO, had granted us a patent covering combinations of vosaroxin with cytarabine. The patent was validated and provides coverage for such combination products in 30 member states of the European Patent Convention and is due to expire in
2025. In November 2010, we announced that the U.S. Patent and Trademark Office granted us a patent covering certain pharmaceutical compositions of vosaroxin, and in March 2011, we announced that the EPO had granted us a similar patent, which we are
proceeding to validate in multiple EPO member states. These patents cover the formulation used in our VALOR trial and are due to expire in 2025. Related patent applications are pending in other major markets throughout the world, including Japan,
Australia and Canada.

As of December 31, 2010, approximately 76 U.S. and foreign applications pertaining to vosaroxin
and compositions and uses thereof were pending. When appropriate, we intend to seek patent term restoration, orphan drug status and/or data exclusivity in the United States and their equivalents in other relevant jurisdictions, to the maximum extent
that the respective laws will permit at such time. In 2009, the FDA granted orphan drug designation to vosaroxin for the treatment of AML.

Our ability to build and maintain our proprietary position for vosaroxin and any future drug candidates, if any, will depend on our success in obtaining effective claims and enforcing those claims if
granted. The patent positions of biopharmaceutical companies like ours are generally uncertain and involve complex legal and factual questions for which some important legal principles remain unresolved. No consistent policy regarding the



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breadth of patent claims has emerged to date in the United States. The patent situation outside the United States is even more uncertain. We do not know whether any of our patent applications or
those patent applications that we license will result in the issuance of any patents. Even if patents are issued, they may not be sufficient to protect vosaroxin or future drug candidates, if any. The patents we own or license and those that
may issue in the future may be opposed, challenged, invalidated or circumvented, and the rights granted under any issued patents may not provide us with proprietary protection or competitive advantages.

Patent applications filed before November 29, 2000 in the United States are maintained in secrecy until patents issue. Later filed
U.S. applications and patent applications in most foreign countries generally are not published until at least 18 months after their earliest filing date. Scientific and patent publication often occurs long after the date of the scientific
discoveries disclosed in those publications. Accordingly, we cannot be certain that we were the first to invent the subject matter covered by any patent application or that we were the first to file a patent application for any inventions.

Our commercial success depends on our ability to operate without infringing patents and proprietary rights of third parties.
We cannot determine with certainty whether patents or patent applications of other parties may materially affect our ability to conduct our business. The existence of third party patent applications and patents could significantly reduce the
coverage of patents owned by or licensed to us and limit our ability to obtain meaningful patent protection. If patents containing competitive or conflicting claims are issued to third parties and these claims are ultimately determined to be valid,
we may be enjoined from pursuing research, development or commercialization of vosaroxin or future drug candidates, if any, or be required to obtain licenses to such patents or to develop or obtain alternative technology.

We may need to commence or defend litigation to enforce or to determine the scope and validity of any patents issued to us or to
determine the scope and validity of third party proprietary rights. Litigation would result in substantial costs, even if the eventual outcome is favorable to us. An adverse outcome in litigation affecting proprietary rights we own or have licensed
could present significant risk of competition for vosaroxin or future drug candidates, if any, that we market or seek to develop. Any adverse outcome in litigation affecting third party proprietary rights could subject us to significant liabilities
to third parties and could require us to seek licenses of the disputed rights from third parties or to cease using the technology if such licenses are unavailable.

We also rely on trade secrets to protect our technology, especially in situations or jurisdictions in which we believe patent protection may not be appropriate or obtainable. However, trade secrets are
difficult to maintain and do not protect technology against independent developments made by third parties.

We seek to
protect our proprietary information by requiring our employees, consultants, contractors and other advisers to execute nondisclosure and assignment of invention agreements upon commencement of their employment or engagement. Agreements with our
employees also prevent them from bringing the proprietary rights of third parties to us. We also require confidentiality or material transfer agreements from third parties that receive our confidential data or materials. There can be no assurance
that these agreements will provide meaningful protection, that these agreements will not be breached, that we will have an adequate remedy for any such breach, or that our trade secrets will not otherwise become known or independently developed by a
third party.

We seek to protect our company name and the names of our products and technologies by obtaining trademark
registrations, as well as common law rights in trademarks and service marks, in the United States and in other countries. There can be no assurance that the trademarks or service marks we use or register will protect our company name or any products
or technologies that we develop and commercialize, that our trademarks, service marks, or trademark registrations will be enforceable against third parties, or that our trademarks and service marks will not interfere with or infringe trademark
rights of third parties. We may need to commence litigation to enforce our trademarks and service marks or to determine the scope and validity of our or a third partys trademark rights. Litigation would result in substantial costs, even if the
eventual outcome is favorable to



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us. An adverse outcome in litigation could subject us to significant liabilities to third parties and require us to seek licenses of the disputed rights from third parties or to cease using the
trademarks or service marks if such licenses are unavailable.

Government Regulation

The FDA and comparable regulatory agencies in state and local jurisdictions and in foreign countries impose substantial requirements upon
the clinical development, manufacture, marketing and distribution of drugs. These agencies and other federal, state and local entities regulate research and development activities and the testing, manufacture, quality control, safety, efficacy,
labeling, storage, recordkeeping, approval, advertising and promotion of vosaroxin and any future drug candidates we may develop, if any. The application of these regulatory frameworks to the development, approval and commercialization of
vosaroxin or our future drug candidates, if any, will take a number of years to accomplish, if at all, and involve the expenditure of substantial resources.

In the United States, the FDA regulates drugs under the Federal Food, Drug, and Cosmetic Act, as amended, and implementing regulations. The process required by the FDA before vosaroxin and any future drug
candidates may be marketed in the United States generally involves the following:



| |  |  | completion of extensive preclinical laboratory tests, in vivo preclinical studies and formulation studies;
| | - |  | ----------------------------------------------------------------------------------------------------------



| |  |  | submission to the FDA of an Investigational New Drug, or IND, application, which must become effective before clinical trials begin;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------



| |  |  | performance of adequate and well-controlled clinical trials to establish the safety and efficacy of the product candidate for each proposed indication;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | submission of an NDA to the FDA;
| | - |  | --------------------------------



| |  |  | satisfactory completion of an FDA pre-approval inspection of the manufacturing facilities at which the product candidate is produced to assess
compliance with current Good Manufacturing Practice, or cGMP, regulations; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | FDA review and approval of the NDA, including proposed labeling (package insert information) and promotional materials, prior to any commercial
marketing, sale or shipment of the drug.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The testing and approval process requires substantial time, effort
and financial resources, and we cannot be certain that any approvals for vosaroxin or our future drug candidates, if any, will be granted on a timely basis, if at all.

The United States Orphan Drug Act promotes the development of products that demonstrate promise for the diagnosis and treatment of diseases or conditions that affect fewer than 200,000 people in the
United States. Upon FDA receipt of Orphan Drug Designation, the sponsor is eligible for tax credits of up to 50% for qualified clinical trial expenses, the ability to apply for annual grant funding, waiver of Prescription Drug User Fee Act (PDUFA)
application fee, and upon approval, the potential for seven years of market exclusivity for the orphan-designated product for the orphan-designated indication.

Preclinical Testing and INDs

Preclinical tests include laboratory
evaluation of product chemistry, formulation and stability, as well as studies to evaluate toxicity in animals. Laboratories that comply with the FDA Good Laboratory Practice regulations must conduct preclinical safety tests. The results of
preclinical tests, together with manufacturing



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information and analytical data, are submitted as part of an IND application to the FDA. The IND automatically becomes effective 30 days after receipt by the FDA, unless the FDA, within the
30-day time period, raises concerns or questions about the conduct of the clinical trial, including concerns that human research subjects will be exposed to unreasonable health risks. In such a case, the IND sponsor and the FDA must resolve any
outstanding concerns before the clinical trial can begin. Our submission of an IND, or those submitted by Biogen Idec or our potential future collaboration partners, if any, may not result in FDA authorization to commence a clinical trial.

Clinical Trials

Clinical trials involve the administration of an IND to healthy volunteers or to patients under the supervision of a qualified principal investigator. Clinical trials are conducted in accordance with the
FDAs Protection of Human Subjects regulations and Good Clinical Practices, or GCP, under protocols that detail the objectives of the study, the parameters to be used to monitor safety, and the efficacy criteria to be evaluated. Each protocol
must be submitted to the FDA as part of the IND application.

In addition, each clinical study must be conducted under the
auspices of an independent institutional review board, or IRB, at each institution where the study will be conducted. Each IRB will consider, among other things, ethical factors, the safety of human subjects and the possible liability of the
institution. The FDA, an IRB or the sponsor may suspend a clinical trial at any time on various grounds, including a finding that the subjects or patients are being exposed to an unacceptable health risk. Clinical testing also must satisfy
extensive GCP requirements and regulations for informed consent.

Clinical trials are typically conducted in three sequential
phases, which may overlap, sometimes followed by a fourth phase:



| |  |  | Phase 1 clinical trials are initially conducted in a limited population to test the drug candidate for safety (adverse effects), dose
tolerance, absorption, metabolism, distribution and excretion in healthy humans or, on occasion, in patients, such as cancer patients. In some cases, particularly in cancer trials, a sponsor may decide to conduct what is referred to as a
Phase 1b evaluation, which is a second safety-focused Phase 1 clinical trial typically designed to evaluate the impact of the drug candidate in combination with currently approved drugs.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase 2 clinical trials are generally conducted in a limited patient population to identify possible adverse effects and safety risks, to
determine the efficacy of the drug candidate for specific targeted indications and to determine dose tolerance and optimal dosage. Multiple Phase 2 clinical trials may be conducted by the sponsor to obtain information prior to beginning larger
and more expensive Phase 3 clinical trials. In some cases, a sponsor may decide to conduct what is referred to as a Phase 2b evaluation, which is a second, confirmatory Phase 2 clinical trial that could, if positive and
accepted by the FDA, serve as a pivotal clinical trial in the approval of a drug candidate.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase 3 clinical trials are commonly referred to as pivotal trials. When Phase 2 clinical trials demonstrate that a drug
candidate has potential activity in a disease or condition and has an acceptable safety profile, Phase 3 clinical trials are undertaken to further evaluate clinical efficacy and to further test for safety in an expanded patient population
at multiple, geographically dispersed clinical trial sites.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase 4 (post-marketing) clinical trials may be required by the FDA in some cases. The FDA may condition approval of an NDA for a drug
candidate on a sponsors agreement to conduct additional clinical trials to further assess the drugs safety and efficacy after NDA approval. Such post-approval trials are typically referred to as Phase 4 clinical trials.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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New Drug Applications

The testing and approval processes are likely to require substantial cost, time and effort, and there can be no assurance that any
approval will be granted on a timely basis, if at all. The FDA may withdraw product approvals if compliance with regulatory standards is not maintained or if problems occur following initial marketing.

The results of development, preclinical testing and clinical trials, together with extensive manufacturing information and a substantial
user fee, are submitted to the FDA as part of an NDA for approval of the marketing and commercial distribution of the drug. The review process routinely takes 10 months but is often significantly extended by FDA requests for additional information
or clarification. The FDA may refer the NDA to an advisory committee for review, evaluation and recommendation as to whether the application should be approved. The FDA is not bound by the recommendation of an advisory committee, but it generally
follows such recommendations. The FDA may deny approval of an NDA if the applicable regulatory criteria are not satisfied, or it may require additional clinical testing. Even if data from such testing are obtained and submitted, the FDA may
ultimately decide that the NDA does not satisfy the criteria for approval. Data from clinical trials are not always conclusive and the FDA may interpret data differently than we or Biogen Idec, or our potential future collaboration partners, if any,
interpret data. If regulatory approval is granted, such approval may entail limitations on the indicated uses for which the product may be marketed.

Once issued, the FDA may withdraw drug approval if ongoing regulatory requirements are not met or if safety problems occur after the drug reaches the market. In addition, the FDA may require testing,
including Phase 4 clinical trials, and surveillance programs to monitor the effect of approved products that have been commercialized, and the FDA has the power to prevent or limit further marketing of a drug based on the results of these
post-marketing programs. Drugs may be marketed only for approved indications and in accordance with the provisions of the approved label. Further, if there are any modifications to the drug, including changes in indications, labeling, or
manufacturing processes or facilities, we may be required to submit and obtain FDA approval of a new NDA or NDA supplement, which may require us to develop additional data or conduct additional preclinical studies and clinical trials.

Fast Track Designation

FDAs fast track program is intended to facilitate the development, and to expedite the review, of drugs that are intended for the treatment of a serious or life-threatening condition for which there
is no effective treatment and demonstrate the potential to address unmet medical needs for the condition.

With fast track
designation, the FDA may initiate review of sections of an NDA before the application is complete. This rolling review is available if the applicant provides and the FDA approves a schedule for the submission of the remaining information and the
applicant pays applicable user fees. However, the time period specified in the Prescription Drug User Fees Act, which governs the time period goals the FDA has committed to reviewing an application, does not begin until the complete application is
submitted. Additionally, the fast track designation may be withdrawn by the FDA if the FDA believes that the designation is no longer supported by data emerging in the clinical trial process.

In some cases, a fast track designated drug candidate may also qualify for one or more of the following programs:



| |  |  | Priority Review.Under FDA policies, a drug candidate is eligible for priority review, or review within six-months from the time a complete
NDA is accepted for filing, if the drug candidate provides a significant improvement compared to marketed drugs in the treatment, diagnosis or prevention of a disease. A fast track designated drug candidate would ordinarily meet the FDAs
criteria for priority review.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | Accelerated Approval.Under the FDAs accelerated approval regulations, the FDA is authorized to approve drug candidates that have
been studied for their safety and efficacy in treating serious or life-threatening illnesses and that provide meaningful therapeutic benefit to patients over existing treatments based upon either a surrogate endpoint that is reasonably likely to
predict clinical benefit or on the basis of an effect on a clinical endpoint other than patient survival. In clinical trials, surrogate endpoints are alternative measurements of the symptoms of a disease or condition that are substituted for
measurements of observable clinical symptoms. A drug candidate approved on this basis is subject to rigorous post-marketing compliance requirements, including the completion of Phase 4 clinical trials to validate the surrogate endpoint or
confirm the effect on the clinical endpoint. Failure to conduct required post-approval studies, or to validate a surrogate endpoint or confirm a clinical benefit during post-marketing studies, will allow the FDA to withdraw the drug from the market
on an expedited basis. All promotional materials for drug candidates approved under accelerated regulations are subject to prior review by the FDA.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

In February 2011, the FDA granted fast track designation to vosaroxin for the potential treatment of relapsed or refractory AML in combination with cytarabine. We do not know whether vosaroxin or our
future drug candidates, if any, will receive a priority review designation or, if a priority designation is received, whether that review or approval will be faster than conventional FDA procedures. We also cannot predict whether vosaroxin or our
future drug candidates, if any, will obtain accelerated approval or priority review, or the ultimate impact, if any, of the fast track or the accelerated approval process on the timing or likelihood of FDA approval of vosaroxin or our future drug
candidates, if any.

Satisfaction of FDA regulations and approval requirements or similar requirements of foreign regulatory
agencies typically takes several years, and the actual time required may vary substantially based upon the type, complexity and novelty of the product or disease. Typically, if a drug candidate is intended to treat a chronic disease, as is the case
with vosaroxin, safety and efficacy data must be gathered over an extended period of time. Government regulation may delay or prevent marketing of drug candidates for a considerable period of time and impose costly procedures upon our activities.
The FDA or any other regulatory agency may not grant approvals for new indications for our drug candidates on a timely basis, or at all. Even if a drug candidate receives regulatory approval, the approval may be significantly limited to specific
disease states, patient populations and dosages. Further, even after regulatory approval is obtained, later discovery of previously unknown problems with a drug may result in restrictions on the drug or even complete withdrawal of the drug from the
market. Delays in obtaining, or failures to obtain, regulatory approvals for any of our drug candidates would harm our business. In addition, we cannot predict what adverse governmental regulations may arise from future U.S. or foreign governmental
action.

Other Regulatory Requirements

Any drugs manufactured or distributed by us or Biogen Idec, or our potential future collaboration partners, if any, pursuant to FDA approvals are subject to continuing regulation by the FDA, including
recordkeeping requirements and reporting of adverse experiences associated with the drug. Drug manufacturers and their subcontractors are required to register with the FDA and certain state agencies, and are subject to periodic unannounced
inspections by the FDA and certain state agencies for compliance with ongoing regulatory requirements, including cGMPs, which impose certain procedural and documentation requirements upon us and our third-party manufacturers. Failure to comply with
the statutory and regulatory requirements can subject a manufacturer to possible legal or regulatory action, such as warning letters, suspension of manufacturing, seizure of product, injunctive action or possible civil penalties.

The FDA closely regulates the post-approval marketing and promotion of drugs, including standards and regulations for direct-to-consumer
advertising, off-label promotion, industry-sponsored scientific and educational activities and promotional activities involving the Internet. A company can make only those claims relating to safety and efficacy that are approved by the FDA. Failure
to comply with these requirements can result in



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adverse publicity, warning letters, corrective advertising and potential civil and criminal penalties. Physicians may prescribe legally available drugs for uses that are not described in the
drugs labeling and that differ from those tested by us and approved by the FDA. Such off-label uses are common across medical specialties, including cancer therapy. Physicians may believe that such off-label uses are the best treatment for
many patients in varied circumstances. The FDA does not regulate the behavior of physicians in their choice of treatments. The FDA does, however, impose stringent restrictions on manufacturers communications regarding off-label use.

Foreign Regulation

In addition to regulations in the United States, we are subject to foreign regulations governing clinical trials and commercial sales and distribution of vosaroxin or our future drug candidates, if any.
Our VALOR trial is expected to enroll patients in Europe, Canada, Australia and New Zealand. We may in the future initiate clinical trials in other countries throughout the world. Whether or not we obtain FDA approval for a product, we must obtain
approval of a product by the comparable regulatory authorities of foreign countries before we can commence clinical trials or marketing of the product in those countries. The approval process varies from country to country, and the time may be
longer or shorter than that required for FDA approval. The requirements governing the conduct of clinical trials, product licensing, pricing and reimbursement vary greatly from country to country.

Under European Union regulatory systems, permission to conduct clinical research is granted by the Competent Authority of each European
Member State, or MS, and the applicable Ethics Committees, or EC, through the submission of a Clinical Trial Application. An EC in the European Union serves the same function as an IRB in the United States. The review times vary by MS but may not
exceed 60 days. The EC has a maximum of 60 days to give its opinion on the acceptability of the Clinical Trial Application to both the governing MS and the sponsor applicant. If the application is deemed acceptable, the MS informs the
applicant (or does not within the 60 day window inform the applicant of non-acceptance) and the company may proceed with the clinical trial.

Under the European Union regulatory systems, marketing authorizations may be submitted either under a centralized or mutual recognition procedure. The centralized procedure provides for the grant of a
single marketing authorization that is valid for all European Union member states. The mutual recognition procedure provides for mutual recognition of national approval decisions. Under this procedure, the holder of a national marketing
authorization may submit an application to the remaining member states. Within 90 days of receiving the application and assessment report, each member state must decide whether to recognize approval.

Under the Canadian regulatory system, Health Canada is the regulatory body that governs the sale of drugs for the purposes of use in
clinical trials. Accordingly, any company that wishes to conduct a clinical trial in Canada must submit a clinical trial application to Health Canada. Health Canada reviews the application and notifies the company within 30 days if the
application is found to be deficient. If the application is deemed acceptable, Health Canada will issue a no objection letter to the company within the 30-day review period which means the company may proceed with its clinical trial(s).

In addition to regulations in the United States, the European Union and Canada, we will be subject to a variety of other foreign
regulations governing clinical trials and commercial distribution of our product candidates. Our ability to sell drugs will also depend on the availability of reimbursement from government and private practice insurance companies.

Research and Development Expenses

We incurred $14.4 million, $13.2 million and $26.3 million of research and development expenses in 2010, 2009 and 2008, respectively. We do not anticipate incurring any significant
additional research expenses related to the discovery of additional product candidates, the development or application of fragment-based drug discovery methods, the development of in-house research capabilities, or on the clinical development of
product



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candidates other than vosaroxin. In addition, we are no longer conducting any research activities in connection with our collaboration with Biogen Idec. However, we have incurred and
expect to continue to incur increased levels of research and development expenses to conduct further clinical and related development of vosaroxin.

Environment

We have made, and will continue to make, expenditures for
environmental compliance and protection. We do not expect that such expenditures will have a material effect on our capital expenditures or results of operations in the foreseeable future.

Employees

As of December 31, 2010, our workforce consisted of 27
full-time employees. Of our total workforce, 17 are engaged in research and development and 10 are engaged in general and administrative functions. We have no collective bargaining agreements with our employees, and we have not experienced any work
stoppages.

Corporate Background

We were incorporated in Delaware in February 1998 as Mosaic Pharmaceuticals, Inc., and subsequently changed our name to Sunesis Pharmaceuticals, Inc. Our offices are headquartered at 395 Oyster
Point Boulevard, Suite 400, South San Francisco, California 94080, and our telephone number is (650) 266-3500. Our website address is www.sunesis.com. Information contained in, or accessible through, our website is not incorporated by
reference into and does not form a part of this report.



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|ITEM 1A. | RISK FACTORS
|-------- | ------------

Investing in our common stock involves a high degree of risk. You should carefully consider the risks and uncertainties described below and all information contained in this report in weighing a decision
to purchase our common stock. If any of the possible adverse events described below actually occurs, we may be unable to conduct our business as currently planned and our financial condition and operating results could be adversely
affected. Additional risks not presently known to us or that we currently believe are immaterial may also significantly impair our business operations. In addition, the trading price of our common stock could decline due to the occurrence of
any of these risks, and you may lose all or part of your investment. Please see Special Note Regarding Forward-Looking Statements.

Risks Related to Our Business

We need to raise substantial additional funding to complete the development and potential commercialization of vosaroxin.

We believe that with $53.4 million in cash and investments as of December 31, 2010, we currently have the resources available and
accessible to fund our operations until the planned unblinding of the VALOR trial in 2013. To the extent that the costs of the VALOR trial exceed our current estimates, unblinding does not occur within the currently anticipated timeframe or we are
unable to raise sufficient additional capital through our controlled equity offering facility or otherwise, we will need to reduce operating expenses, enter into a collaboration or other similar arrangement with respect to development and/or
commercialization rights to vosaroxin, outlicense intellectual property rights to vosaroxin, sell assets, or a combination of the above. We will need to raise substantial additional capital if we expand the number of patients included in the trial
based on the pre-specified interim analysis of data from the trial by the DSMB.

In addition, we will need to raise
substantial additional capital to:



| |  |  | complete the development and potential commercialization of vosaroxin;
| | - |  | ----------------------------------------------------------------------



| |  |  | fund additional clinical trials of vosaroxin and seek regulatory approvals;
| | - |  | ---------------------------------------------------------------------------



| |  |  | expand our development activities;
| | - |  | ----------------------------------



| |  |  | implement additional internal systems and infrastructure; and
| | - |  | -------------------------------------------------------------



| |  |  | build or access commercialization and additional manufacturing capabilities and supplies.
| | - |  | -----------------------------------------------------------------------------------------

Our future funding requirements and sources will depend on many factors, including but not limited to:



| |  |  | the rate of progress and cost of our clinical trials, including the VALOR trial in particular;
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | the need for additional or expanded clinical trials (including in particular potential expansion of the number of patients included in the VALOR trial
based on the pre-specified interim analysis of data from the trial by the DSMB);
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the economic and other terms and timing of any licensing, collaboration or other similar arrangement into which we may enter;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs and timing of seeking and obtaining FDA and other regulatory approvals;
| | - |  | ---------------------------------------------------------------------------------



| |  |  | the extent of our other development activities;
| | - |  | -----------------------------------------------



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| |  |  | the costs associated with building or accessing commercialization and additional manufacturing capabilities and supplies;
| | - |  | -------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs of acquiring or investing in businesses, product candidates and technologies, if any;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | the costs of filing, prosecuting, defending and enforcing any patent claims and other intellectual property rights; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------



| |  |  | the effect of competing technological and market developments.
| | - |  | --------------------------------------------------------------

Until we can generate a sufficient amount of licensing or collaboration or product revenue to finance our cash requirements, which we may
never do, we expect to finance future cash needs primarily through equity issuances, debt arrangements, a possible license, collaboration or other similar arrangement with respect to development and/or commercialization rights to vosaroxin, or a
combination of the above. Any issuance of convertible debt securities, preferred stock or common stock may be at a discount from the then-current trading price of our common stock. If we issue additional common or preferred stock or securities
convertible into common stock, our stockholders will experience additional dilution, which may be significant. Further, we do not know whether additional funding will be available on acceptable terms, or at all. If we are unable to raise substantial
additional funding on acceptable terms or at all, we will be forced to delay or reduce the scope of our vosaroxin development program, potentially including the VALOR trial, and/or limit or cease our operations.

We may not be able to raise necessary additional funding pursuant to our controlled equity offering facility with Cantor and, as a
result, may need to try to obtain additional capital through alternative financing options then available to us, if any, to fully finance the VALOR trial through to its unblinding and otherwise continue our operations.

On April 28, 2010, we entered into a controlled equity offering sales agreement with Cantor, pursuant to which we may issue and sell
shares of our common stock having an aggregate offering price of up to $20.0 million from time to time through Cantor acting as agent and/or principal. As of March 15, 2011, we had sold an aggregate of 3.7 million shares of common stock at
an average price of $4.32 per share for gross proceeds of $16.0 million. As of March 15, 2011, approximately $4.0 million of common stock was available to be sold under this facility, subject to certain conditions as specified in the agreement.
Notwithstanding, we may be limited under the terms of the facility in the number of shares of common stock we may issue and the resulting amount of capital that we could raise pursuant thereto. Any such limitation may be due to a number of factors,
including as a result of the termination of the facility due to a material breach of its terms by us or Cantors election to terminate the facility in its discretion. In addition, we may be subject to limitations on the number of shares of
common stock we may sell pursuant to the facility due to the eligibility requirements for use of a Form S-3 Registration Statement and other applicable legal restrictions. As a result, there is no assurance that the controlled equity offering
facility will be available when required or that we will be able to raise the necessary funding pursuant thereto in order to fully finance the VALOR trial until its planned unblinding and otherwise continue our operations. In such event, we will
need to raise additional capital through alternative financing options then available to us, if any.

We have incurred
losses since inception and anticipate that we will continue to incur losses for the foreseeable future. We may not ever achieve or sustain profitability.

We are not profitable and have incurred losses in each year since our inception in 1998. Our net losses for the years ended December 31, 2010, 2009 and 2008 were $24.6 million, $40.2 million and
$37.2 million, respectively. As of December 31, 2010, we had an accumulated deficit of $381.0 million. We do not currently have any products that have been approved for marketing, and we continue to incur substantial development and general and
administrative expenses related to our operations. We expect to continue to incur losses for the foreseeable future, and we expect these losses to increase significantly as the VALOR trial progresses, as we seek



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regulatory approvals for vosaroxin, and as we commercialize vosaroxin, if approved. Our losses, among other things, have caused and will continue to cause our stockholders equity and
working capital to decrease.

To date, we have derived substantially all of our revenue from research collaboration agreements
with Biogen Idec, Merck and J&J PRD. As of December 31, 2010, our only remaining ongoing collaboration is with Biogen Idec; however, the research phase for this collaboration is completed. On November 3, 2010, Biogen Idec
announced that it will seek to spin out or outlicense certain oncology assets, including the collaboration agreement with us. We cannot predict the outcome of this strategic decision by Biogen Idec or its impact on future development activity
under our collaboration agreement or on our prospects for the receipt of milestone or royalty payments under the collaboration agreement. We do not expect to enter into any new collaboration agreement that will result in research revenue for us. We
also do not anticipate that we will generate revenue from the sale of products for the foreseeable future. In the absence of additional sources of capital, which may not be available to us on acceptable terms, or at all, the development of vosaroxin
or future product candidates, if any, may be reduced in scope, delayed or terminated. If our product candidates or those of our collaborators fail in clinical trials or do not gain regulatory approval, or if our future products do not achieve market
acceptance, we may never become profitable. Even if we achieve profitability in the future, we may not be able to sustain profitability in subsequent periods.

The development of vosaroxin could be halted or significantly delayed for various reasons; our clinical trials for vosaroxin may not demonstrate safety or efficacy or lead to regulatory approval.

Vosaroxin is vulnerable to the risks of failure inherent in the drug development process. We need to conduct
significant additional preclinical studies and clinical trials before we can attempt to demonstrate that vosaroxin is safe and effective to the satisfaction of the FDA and other regulatory authorities. Failure can occur at any stage of the
development process, and successful preclinical studies and early clinical trials do not ensure that later clinical trials will be successful. A number of companies in the pharmaceutical industry have suffered significant setbacks in advanced
clinical trials, even after obtaining promising results in earlier trials.

For example, we terminated two Phase 2 clinical
trials of vosaroxin in small cell and non-small cell lung cancer. If our clinical trials result in unacceptable toxicity or lack of efficacy, we may have to terminate them. If clinical trials are halted, or if they do not show that vosaroxin is safe
and effective in the indications for which we are seeking regulatory approval, our future growth will be limited and we may not have any other product candidates to develop.

We do not know whether our ongoing clinical trials or any other future clinical trials with vosaroxin or any of our product candidates, including the VALOR trial in particular, will be completed on
schedule, or at all, or whether our ongoing or planned clinical trials will begin or progress on the time schedule we anticipate. The commencement of our planned or future clinical trials could be substantially delayed or prevented by several
factors, including:



| |  |  | delays or failures to raise additional funding;
| | - |  | -----------------------------------------------



| |  |  | results of meetings with the FDA and/or other regulatory bodies;
| | - |  | ----------------------------------------------------------------



| |  |  | a limited number of, and competition for, suitable patients with particular types of cancer for enrollment in our clinical trials;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



| |  |  | delays or failures in obtaining regulatory approval to commence a clinical trial;
| | - |  | ---------------------------------------------------------------------------------



| |  |  | delays or failures in obtaining sufficient clinical materials;
| | - |  | --------------------------------------------------------------



| |  |  | delays or failures in obtaining approval from independent institutional review boards to conduct a clinical trial at prospective sites; or
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | delays or failures in reaching acceptable clinical trial agreement terms or clinical trial protocols with prospective sites.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------

The completion of our clinical trials could also be substantially delayed or prevented by several factors,
including:



| |  |  | delays or failures to raise additional funding;
| | - |  | -----------------------------------------------



| |  |  | slower than expected rates of patient recruitment and enrollment;
| | - |  | -----------------------------------------------------------------



| |  |  | failure of patients to complete the clinical trial;
| | - |  | ---------------------------------------------------



| |  |  | delays or failures in reaching the number of events pre-specified in the trial design;
| | - |  | --------------------------------------------------------------------------------------



| |  |  | the need to expand the clinical trial (including, in particular, potential expansion of the number of patients included in our VALOR trial based on the
pre-specified interim analysis of data by the DSMB);
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | delays or failures in obtaining sufficient clinical materials, including vosaroxin, its matching placebo and cytarabine;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | unforeseen safety issues;
| | - |  | -------------------------



| |  |  | lack of efficacy during clinical trials;
| | - |  | ----------------------------------------



| |  |  | inability or unwillingness of patients or clinical investigators to follow our clinical trial protocols; and
| | - |  | ------------------------------------------------------------------------------------------------------------



| |  |  | inability to monitor patients adequately during or after treatment.
| | - |  | -------------------------------------------------------------------

Additionally, our clinical trials may be suspended or terminated at any time by the FDA, other regulatory authorities, or ourselves. Any
failure to complete or significant delay in completing clinical trials for our product candidates could harm our financial results and the commercial prospects for our product candidates.

We rely on a limited number of third-party manufacturers that are capable of manufacturing vosaroxin API and FDP to supply us with
our vosaroxin API and FDP and the placebo used in the VALOR trial. If we fail to obtain sufficient quantities of these materials, the VALOR trial and the development of vosaroxin could be halted or significantly delayed. In addition, we have
previously identified product impurities in the vosaroxin API, and there is no assurance they will not occur in the future.

We do not currently own or operate manufacturing facilities and lack the capability to manufacture vosaroxin on a clinical or commercial scale. As a result, we rely on third parties to manufacture
vosaroxin API and FDP and the placebo product used in the VALOR trial. The vosaroxin API is classified as a cytotoxic substance, limiting the number of available manufacturers.

We currently rely on two contract manufacturers for the vosaroxin API, which is manufactured through a multi-step convergent synthesis in
which two intermediates are manufactured in a parallel process and then combined and de-protected in the final two steps. We recently started working with the second vosaroxin API manufacturer, and to date no vosaroxin FDP has been formulated from
the vosaroxin API supplied by this second manufacturer. We also currently rely on a single contract manufacturer to formulate the vosaroxin API and fill and finish vials of the vosaroxin FDP.



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If our third-party vosaroxin API or FDP manufacturers are unable or unwilling to produce the
vosaroxin API or FDP or placebo we require, we would need to establish arrangements with one or more alternative suppliers. However, establishing a relationship with an alternative supplier would likely delay our ability to produce vosaroxin API or
FDP for six to nine months. Our ability to replace an existing manufacturer would also be difficult and time consuming because the number of potential manufacturers is limited and the FDA must approve any replacement manufacturer before it can be an
approved commercial supplier. Such approval would require new testing and compliance inspections. It may be difficult or impossible for us to identify and engage a replacement manufacturer on acceptable terms in a timely manner, or at all. We expect
to continue to depend on third-party contract manufacturers for all our vosaroxin API, FDP and placebo needs for the foreseeable future.

Vosaroxin requires precise, high quality manufacturing. We have observed visible particles during stability studies of two vosaroxin FDP lots. We have since identified a process impurity in the vosaroxin
API that, when formulated into the packaged vial of the vosaroxin FDP, can result in the formation of particles over time. As a response to these findings, we implemented, and continue to monitor and adjust, a revised manufacturing process to seek
to control the impurity and thereby prevent particle formation. Two lots of vosaroxin API manufactured using a revised manufacturing process were formulated into FDP lots that have both completed up to 24 months of stability testing at room
temperature without formation of particles. It will take time to evaluate whether or not our revised manufacturing process for vosaroxin API will be successful in stopping the formation of particles in FDP lots over the longer term, and to evaluate
whether or not such control of particle formation can also be reliably and consistently achieved in subsequent lots over the shorter or longer term. If our changes in manufacturing process do not adequately control the formation of visible
particles, we will need to discuss other possibilities with the FDA and/or other regulatory bodies, which could include a temporary clinical hold of the VALOR trial until the issue has been resolved to their satisfaction.

In addition to process impurities, our contract manufacturers failure to achieve and maintain high manufacturing standards in
compliance with cGMP regulations could result in other manufacturing errors leading to patient injury or death, product recalls or withdrawals, delays or interruptions of production or failures in product testing or delivery. Although contract
manufacturers are subject to ongoing periodic unannounced inspection by the FDA and corresponding state agencies to ensure strict compliance with cGMP and other applicable government regulations and corresponding foreign standards, any such
performance failures on the part of a contract manufacturer could result in the delay or prevention of filing or approval of marketing applications for vosaroxin, cost overruns or other problems that could seriously harm our business. This would
deprive us of potential product revenue and result in additional losses.

To date, vosaroxin has been manufactured in
quantities appropriate for preclinical studies and clinical trials. New lots of API and FDP will need to be manufactured and released to support our VALOR trial and stability assessments required for regulatory approval. There can be no assurance
that we will be able to obtain a sufficient supply of vosaroxin API and FDP to supply our VALOR trial at the anticipated rate of enrollment or to continue the trial without interruption. Prior to being approved for commercial sale, we will need to
manufacture API and FDP in larger quantities. Any significant scale-up of manufacturing will be accompanied by process validation studies, which are required to be reviewed by the FDA prior to approval. If we are unable to successfully increase the
manufacturing capacity for vosaroxin, the regulatory approval or commercial launch may be delayed or there may be a shortage in commercial supply.

We rely on third-party distributors for the supply of cytarabine for our VALOR trial. Cytarabine is in short supply throughout the world, and there is no guarantee we can procure sufficient
quantities to supply our VALOR trial.

The cytarabine used in our VALOR trial is procured from third-party
distributors. Cytarabine is currently in short supply throughout the world. Additional procurement of cytarabine will be necessary to complete the VALOR trial. If we are unable to procure the necessary supplies to support our VALOR trial, the trial
will be delayed. Any significant delay could seriously harm our business.



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The failure to enroll patients for clinical trials may cause delays in developing
vosaroxin.

We may encounter delays if we are unable to enroll enough patients to complete clinical trials of
vosaroxin, including the VALOR trial. Patient enrollment depends on many factors, including the size of the patient population, the nature of the protocol, the proximity of patients to clinical sites, the number and nature of competing treatments
and ongoing clinical trials of competing drugs for the same indication, and the eligibility criteria for the trial. Patients participating in our trials may elect to leave our trials and switch to alternative treatments that are available to them,
either commercially or on an expanded access basis, or in other clinical trials. Competing treatments include nucleoside analogs, anthracyclines and hypomethylating agents. Moreover, when one product candidate is evaluated in multiple clinical
trials simultaneously, patient enrollment in ongoing trials can be adversely affected by negative results from completed trials. In the VALOR trial, vosaroxin is being tested in patients with AML, which can be a difficult patient population to
recruit.

The results of preclinical studies and clinical trials may not satisfy the requirements of the FDA or other
regulatory agencies.

Prior to receiving approval to commercialize vosaroxin or future product candidates, if any, in
the United States or abroad, we must demonstrate with substantial evidence from well-controlled clinical trials, to the satisfaction of the FDA and other regulatory authorities, that such product candidates are safe and effective for their intended
uses. The results from preclinical studies and clinical trials can be interpreted in different ways, and the favorable results from previous trials of vosaroxin may not be experienced in the VALOR trial. Even if we believe the preclinical or
clinical data are promising, such data may not be sufficient to support approval by the FDA and other regulatory authorities. In addition, although we believe that our discussions with the FDA support the potential approval of vosaroxin for the
treatment of AML based on positive results from the VALOR trial without the need to conduct additional clinical trials, the FDA has substantial discretion in the approval process and may not grant approval based on data from this trial.

We rely on third parties to conduct our clinical trials. If these third parties do not successfully carry out their contractual
duties or meet expected deadlines, we may be unable to obtain regulatory approval for or commercialize vosaroxin.

We
rely on third parties, such as contract research organizations, medical institutions, clinical investigators and contract laboratories, to conduct our planned and existing clinical trials for vosaroxin. If the third parties conducting our clinical
trials do not perform their contractual duties or obligations, do not meet expected deadlines or need to be replaced, or if the quality or accuracy of the clinical data they obtain is compromised due to the failure to adhere to our clinical trial
protocols or for any other reason, we may need to enter into new arrangements with alternative third parties and our clinical trials may be extended, delayed or terminated or may need to be repeated, and we may not be able to obtain regulatory
approval for or commercialize the product candidate being tested in such trials.

We expect to expand our development
capabilities, and any difficulties hiring or retaining key personnel or managing this growth could disrupt our operations.

We are highly dependent on the principal members of our development staff. We expect to expand our development capabilities by increasing expenditures in these areas, hiring additional employees and
potentially expanding the scope of our current operations. Future growth will require us to continue to implement and improve our managerial, operational and financial systems and continue to retain, recruit and train additional qualified personnel,
which may impose a strain on our administrative and operational infrastructure. The competition for qualified personnel in the biopharmaceutical field is intense. We are highly dependent on our continued ability to attract, retain and motivate
highly qualified management and specialized personnel required for clinical development. Due to our limited resources, we may not be able to effectively manage any expansion of our operations or recruit and train additional qualified personnel. If
we are unable to retain key personnel or manage our growth effectively, we may not be able to implement our business plan.



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If we are sued for infringing intellectual property rights of third parties,
litigation will be costly and time consuming and could prevent us from developing or commercializing vosaroxin.

Our
commercial success depends on not infringing the patents and other proprietary rights of third parties and not breaching any collaboration or other agreements we have entered into with regard to our technologies and product candidates. If a third
party asserts that we are using technology or compounds claimed in issued and unexpired patents owned or controlled by the third party, we may need to obtain a license, enter into litigation to challenge the validity of the patents or incur the risk
of litigation in the event that a third party asserts that we infringe its patents.

If a third party asserts that we infringe
its patents or other proprietary rights, we could face a number of challenges that could seriously harm our competitive position, including:



| |  |  | infringement and other intellectual property claims, which would be costly and time consuming to litigate, whether or not the claims have merit, and
which could delay the regulatory approval process and divert managements attention from our business;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | substantial damages for past infringement, which we may have to pay if a court determines that vosaroxin or any future product candidates infringe a
third partys patent or other proprietary rights;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | a court order prohibiting us from selling or licensing vosaroxin or any future product candidates unless a third party licenses relevant patent or
other proprietary rights to us, which it is not required to do; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | if a license is available from a third party, we may have to pay substantial royalties or grant cross-licenses to our patents or other proprietary
rights.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------

If our competitors develop and market products that are more effective, safer or less
expensive than vosaroxin, our commercial opportunities will be negatively impacted.

The life sciences industry is
highly competitive, and we face significant competition from many pharmaceutical, biopharmaceutical and biotechnology companies that are researching, developing and marketing products designed to address the treatment of cancer, including AML and
ovarian cancer. Many of our competitors have significantly greater financial, manufacturing, marketing and drug development resources than we do. Large pharmaceutical companies in particular have extensive experience in the clinical testing of,
obtaining regulatory approvals for, and marketing drugs.

We believe that our ability to successfully compete in the
marketplace with vosaroxin and any future product candidates, if any, will depend on, among other things:



| |  |  | our ability to develop novel compounds with attractive pharmaceutical properties and to secure, protect and maintain intellectual property rights based
on our innovations;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the efficacy, safety and reliability of our product candidates;
| | - |  | ---------------------------------------------------------------



| |  |  | the speed at which we develop our product candidates;
| | - |  | -----------------------------------------------------



| |  |  | our ability to design and successfully execute appropriate clinical trials;
| | - |  | ---------------------------------------------------------------------------



| |  |  | our ability to maintain a good relationship with regulatory authorities;
| | - |  | ------------------------------------------------------------------------



| |  |  | our ability to obtain, and the timing and scope of, regulatory approvals;
| | - |  | -------------------------------------------------------------------------



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| |  |  | our ability to manufacture and sell commercial quantities of future products to the market; and
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | acceptance of future products by physicians and other healthcare providers.
| | - |  | ---------------------------------------------------------------------------

Vosaroxin is a small molecule therapeutic that will compete with other drugs and therapies that currently exist or are being developed.
There are a number of compounds in development for the treatment of AML, including Genzyme Corporations clofarabine and Celgene Corporations azacitidine. Each of these or other compounds could become potential competitors for
vosaroxin, if approved.

We expect competition for vosaroxin for the treatment of AML to increase as additional products are
developed and approved in various patient populations. If our competitors market products that are more effective, safer or less expensive than vosaroxin or our other future products, if any, or that reach the market sooner we may not achieve
commercial success or substantial market penetration. In addition, the biopharmaceutical industry is characterized by rapid change. Products developed by our competitors may render vosaroxin or any future product candidates obsolete.

Our proprietary rights may not adequately protect vosaroxin or future product candidates, if any.

Our commercial success will depend on our ability to obtain patents and maintain adequate protection for vosaroxin and any future product
candidates in the United States and other countries. We own, co-own or have rights to a significant number of issued U.S. and foreign patents and pending U.S. and foreign patent applications. We will be able to protect our proprietary rights from
unauthorized use by third parties only to the extent that our proprietary technologies and future products are covered by valid and enforceable patents or are effectively maintained as trade secrets.

We apply for patents covering both our technologies and product candidates, as we deem appropriate. However, we may fail to apply for
patents on important technologies or product candidates in a timely fashion, or at all. Our existing patents and any future patents we obtain may not be sufficiently broad to prevent others from practicing our technologies or from developing
competing products and technologies. In addition, we generally do not exclusively control the patent prosecution of subject matter that we license to or from others. Accordingly, in such cases we are unable to exercise the same degree of control
over this intellectual property as we would over our own. Moreover, the patent positions of biopharmaceutical companies are highly uncertain and involve complex legal and factual questions for which important legal principles remain unresolved. As a
result, the validity and enforceability of patents cannot be predicted with certainty. In addition, we do not know whether:



| |  |  | we, our licensors or our collaboration partners were the first to make the inventions covered by each of our issued patents and pending patent
applications;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | we, our licensors or our collaboration partners were the first to file patent applications for these inventions;
| | - |  | ----------------------------------------------------------------------------------------------------------------



| |  |  | others will independently develop similar or alternative technologies or duplicate any of our technologies;
| | - |  | -----------------------------------------------------------------------------------------------------------



| |  |  | any of our or our licensors pending patent applications will result in issued patents;
| | - |  | ---------------------------------------------------------------------------------------



| |  |  | any of our, our licensors or our collaboration partners patents will be valid or enforceable;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | any patents issued to us, our licensors or our collaboration partners will provide us with any competitive advantages, or will be challenged by third
parties;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | we will develop additional proprietary technologies that are patentable; or
| | - |  | ---------------------------------------------------------------------------



| |  |  | the patents of others will have an adverse effect on our business.
| | - |  | ------------------------------------------------------------------



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We also rely on trade secrets to protect some of our technology, especially where we do not
believe patent protection is appropriate or obtainable. However, trade secrets are difficult to maintain. While we use reasonable efforts to protect our trade secrets, our or our collaboration partners employees, consultants, contractors or
scientific and other advisors, or those of our licensors, may unintentionally or willfully disclose our proprietary information to competitors. Enforcement of claims that a third party has illegally obtained and is using trade secrets is expensive,
time consuming and uncertain. In addition, foreign courts are sometimes less willing than U.S. courts to protect trade secrets. If our competitors independently develop equivalent knowledge, methods and know-how, we would not be able to assert our
trade secrets against them and our business could be harmed.

The composition of matter patents covering vosaroxin are
due to expire in 2015. Even if vosaroxin is approved by the FDA and foreign equivalents thereof, we may not be able to recover our development costs prior to the expiration of these patents.

The vosaroxin composition of matter is covered by U.S. patent 5,817,669 and its counterpart patents in 43 foreign jurisdictions. U.S.
patent 5,817,669 is due to expire in October 2015, and most of its foreign counterparts are due to expire in June 2015. In July 2010, we announced that the European Patent Office, or EPO, had granted us a patent covering combinations of vosaroxin
with cytarabine. The patent was validated and provides coverage for such combination products in 30 member states of the European Patent Convention and is due to expire in 2025. In November 2010, we announced that the U.S. Patent and Trademark
Office had granted us a patent covering certain pharmaceutical compositions of vosaroxin, and in March 2011, we announced that the EPO had granted us a similar patent, which we are proceeding to validate in multiple EPO member states. These patents
cover the formulation used in our VALOR trial and are due to expire in 2025. We do not know whether patent term extensions and data exclusivity periods will be available in the future. Vosaroxin must undergo extensive clinical trials before it can
be approved by the FDA. We do not know when, if ever, vosaroxin will be approved by the FDA. Even if vosaroxin is approved by the FDA in the future, we may not have sufficient time to commercialize our vosaroxin product to enable us to recover our
development costs prior to the expiration of the U.S. and foreign patents covering vosaroxin. Our obligation to pay royalties to Dainippon, the company from which we licensed vosaroxin, may extend beyond the patent expiration, which would further
erode the profitability of this product.

Any future workforce and expense reductions may have an adverse impact on our
internal programs, our ability to hire and retain key personnel and may be distracting to management.

We have, in the
past, implemented a number of workforce reductions. Depending on our need for additional funding and expense control, we may be required to implement further workforce and expense reductions in the future. Further workforce and expense reductions
could result in reduced progress on our internal programs. In addition, employees, whether or not directly affected by a reduction, may seek future employment with our business partners or competitors. Although our employees are required to sign a
confidentiality agreement at the time of hire, the confidential nature of certain proprietary information may not be maintained in the course of any such future employment. Further, we believe that our future success will depend in large part upon
our ability to attract and retain highly skilled personnel. We may have difficulty retaining and attracting such personnel as a result of a perceived risk of future workforce and expense reductions. In addition, the implementation of expense
reduction programs may result in the diversion of efforts of our executive management team and other key employees, which could adversely affect our business.

We may be subject to damages resulting from claims that we or our employees have wrongfully used or disclosed alleged trade secrets of our employees former employers.

Many of our employees were previously employed at biotechnology or pharmaceutical companies, including our competitors or potential
competitors. We may be subject to claims that we or our employees have inadvertently or otherwise used or disclosed trade secrets or other proprietary information of their former employers. Litigation may be necessary to defend against these claims.
If we fail in defending such claims, in



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addition to paying monetary damages, we may lose valuable intellectual property rights or personnel. A loss of key personnel or the work product of current or former personnel could hamper or
prevent our ability to commercialize vosaroxin, which could severely harm our business. Even if we are successful in defending against these claims, litigation could result in substantial costs and be a distraction to management.

We currently have limited marketing staff and no sales or distribution organization. If we are unable to develop a sales and
marketing and distribution capability on our own or through collaborations with marketing partners, we will not be successful in commercializing vosaroxin.

We currently have no sales or distribution capabilities and limited marketing staff. We intend to establish our own sales and marketing organization with technical expertise and supporting distribution
capabilities to commercialize vosaroxin in North America, which will be expensive and time consuming. Any failure or delay in the development of our internal sales, marketing and distribution capabilities would adversely impact the commercialization
of these products. We plan to collaborate with third parties that have direct sales forces and established distribution systems to commercialize vosaroxin. To the extent that we enter into co-promotion or other licensing arrangements, our product
revenue is likely to be lower than if we marketed or sold vosaroxin directly. In addition, any revenue we receive will depend upon the efforts of third parties, which may not be successful and are only partially within our control. If we are unable
to enter into such arrangements on acceptable terms or at all, we may not be able to successfully commercialize vosaroxin. If we are not successful in commercializing vosaroxin or our future product candidates, if any, either on our own or through
collaborations with one or more third parties, our future product revenue will suffer and we may incur significant additional losses.

We depend on various consultants and advisors for the success and continuation of our development efforts.

We work extensively with various consultants and advisors, who provide advice and or services in various business and development functions, including clinical development, operations and strategy,
regulatory matters, accounting and finance. The potential success of our drug development programs depends, in part, on continued collaborations with certain of these consultants and advisors. Our consultants and advisors are not our employees and
may have commitments and obligations to other entities that may limit their availability to us. We do not know if we will be able to maintain such relationships or that such consultants and advisors will not enter into other arrangements with
competitors, any of which could have a detrimental impact on our development objectives and our business.

If conflicts
of interest arise between our current or future collaboration partners, if any, and us, any of them may act in their self interest, which may be adverse to our interests.

If a conflict of interest arises between us and one or more of our current or potential future collaboration partners, if any, they may
act in their own self interest or otherwise in a way that is not in the interest of our company or our stockholders. Biogen Idec or potential future collaboration partners, if any, are conducting or may conduct product development efforts within the
disease area that is the subject of collaboration with our company. In current or potential future collaborations, if any, we have agreed or may agree not to conduct, independently or with any third party, any research that is competitive with the
research conducted under our collaborations. Our collaboration partners, however, may develop, either alone or with others, products in related fields that are competitive with the product candidates that are the subject of these collaborations.
Competing products, either developed by our collaboration partners or to which our collaboration partners have rights, may result in their withdrawal of support for a product candidate covered by the collaboration agreement.

If one or more of our current or potential future collaboration partners, if any, were to breach or terminate their collaboration
agreements with us or otherwise fail to perform their obligations thereunder in a timely manner, the preclinical or clinical development or commercialization of the affected product candidates could be



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delayed or terminated. We do not know whether our collaboration partners will pursue alternative technologies or develop alternative product candidates, either on their own or in collaboration
with others, including our competitors, as a means for developing treatments for the diseases targeted by collaboration agreements with our company.

Compliance with changing regulation of corporate governance and public disclosure may result in additional expenses.

Changing laws, regulations and standards relating to corporate governance and public disclosure may create uncertainty regarding compliance matters. New or changed laws, regulations and standards are
subject to varying interpretations in many cases. As a result, their application in practice may evolve over time. We are committed to maintaining high standards of corporate governance and public disclosure. Complying with evolving interpretations
of new or changed legal requirements may cause us to incur higher costs as we revise current practices, policies and procedures, and may divert management time and attention from potential revenue-generating activities to compliance matters. If our
efforts to comply with new or changed laws, regulations and standards differ from the activities intended by regulatory or governing bodies due to ambiguities related to practice, our reputation may also be harmed. Further, our board members, chief
executive officer and chief financial officer could face an increased risk of personal liability in connection with the performance of their duties. As a result, we may have difficulty attracting and retaining qualified board members and executive
officers, which could harm our business.

We are exposed to risks related to foreign currency exchange
rates.

Some of our costs and expenses are denominated in foreign currencies. Most of our foreign expenses are
associated with activities related to the VALOR trial that are occurring outside of the United States, and in particular in Western Europe. When the U.S. dollar weakens against the Euro or British pound, the U.S. dollar value of the foreign currency
denominated expense increases, and when the U.S. dollar strengthens against the Euro or British pound, the U.S. dollar value of the foreign currency denominated expense decreases. Consequently, changes in exchange rates, and in particular a
weakening of the U.S. dollar, may adversely affect our results of operations. We may purchase certain European currencies or highly-rated investments denominated in such currencies to manage the risk of future movements in foreign
exchange rates that would affect such payables in accordance with our investment policy. However, there is no guarantee that the related gains and losses will substantially offset each other, and we may be subject to significant exchange
gains or losses as currencies fluctuate from quarter to quarter.

Our facilities are located near known earthquake fault
zones, and the occurrence of an earthquake or other catastrophic disaster could cause damage to our facilities and equipment, which could require us to cease or curtail operations.

Our facilities are located in the San Francisco Bay Area near known earthquake fault zones and are vulnerable to significant damage from
earthquakes. We are also vulnerable to damage from other types of disasters, including fires, floods, power loss, communications failures and similar events. If any disaster were to occur, our ability to operate our business at our facilities may be
seriously or completely impaired and our data could be lost or destroyed.

Risks Related to Our Industry

The regulatory approval process is expensive, time consuming and uncertain and may prevent us from obtaining approval for the
commercialization of vosaroxin.

The research, testing, manufacturing, selling and marketing of product candidates are
subject to extensive regulation by the FDA and other regulatory authorities in the United States and other countries, which regulations differ from country to country. Neither we nor our collaboration partners are permitted to market our product



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candidates in the United States until we receive approval of an NDA from the FDA, or in any other country without the equivalent marketing approval from such country. We have not received
marketing approval for vosaroxin in any jurisdiction. None of our collaboration partners have had a product resulting from our collaboration enter clinical trials. In addition, failure to comply with FDA and other applicable U.S. and foreign
regulatory requirements may subject us to administrative or judicially imposed sanctions, including warning letters, civil and criminal penalties, injunctions, product seizure or detention, product recalls, total or partial suspension of production,
and refusal to approve pending NDAs, supplements to approved NDAs or their foreign equivalents.

Regulatory approval of an NDA
or NDA supplement or a foreign equivalent is not guaranteed, and the approval process is expensive, uncertain and may take several years. Furthermore, the development process for oncology products may take longer than in other therapeutic areas.
Regulatory authorities have substantial discretion in the drug approval process. Despite the time and expense exerted, failure can occur at any stage, and we could encounter problems that cause us to abandon clinical trials or to repeat or perform
additional preclinical studies and clinical trials. The number of preclinical studies and clinical trials that will be required for marketing approval varies depending on the drug candidate, the disease or condition that the drug candidate is
designed to address, and the regulations applicable to any particular drug candidate. In particular, although we believe that our discussions with the FDA support the potential approval of vosaroxin for the treatment of AML based on positive results
from the VALOR trial without the need to conduct additional clinical trials, the FDA has substantial discretion in the approval process and may not grant approval based on data from this trial.

The FDA or a foreign regulatory authority can delay, limit or deny approval of a drug candidate for many reasons, including:



| |  |  | the drug candidate may not be deemed safe or effective;
| | - |  | -------------------------------------------------------



| |  |  | regulatory officials may not find the data from preclinical studies and clinical trials sufficient;
| | - |  | ---------------------------------------------------------------------------------------------------



| |  |  | the FDA or foreign regulatory authority might not approve our or our third-party manufacturers processes or facilities; or
| | - |  | ---------------------------------------------------------------------------------------------------------------------------



| |  |  | the FDA or foreign regulatory authority may change its approval policies or adopt new regulations.
| | - |  | --------------------------------------------------------------------------------------------------

We may be subject to costly claims related to our clinical trials and may not be able to obtain adequate insurance.

Because we conduct clinical trials in humans, we face the risk that the use of vosaroxin or future product
candidates, if any, will result in adverse side effects. We cannot predict the possible harms or side effects that may result from our clinical trials. Although we have clinical trial liability insurance for up to $10.0 million in aggregate, our
insurance may be insufficient to cover any such events. We do not know whether we will be able to continue to obtain clinical trial coverage on acceptable terms, or at all. We may not have sufficient resources to pay for any liabilities resulting
from a claim excluded from, or beyond the limit of, our insurance coverage. There is also a risk that third parties that we have agreed to indemnify could incur liability. Any litigation arising from our clinical trials, even if we were ultimately
successful, would consume substantial amounts of our financial and managerial resources and may create adverse publicity.



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Even if we receive regulatory approval to sell vosaroxin, the market may not be
receptive to vosaroxin.

Even if vosaroxin obtains regulatory approval, it may not gain market acceptance among
physicians, patients, healthcare payors and/or the medical community. We believe that the degree of market acceptance will depend on a number of factors, including:



| |  |  | timing of market introduction of competitive products;
| | - |  | ------------------------------------------------------



| |  |  | efficacy of our product;
| | - |  | ------------------------



| |  |  | prevalence and severity of any side effects;
| | - |  | --------------------------------------------



| |  |  | potential advantages or disadvantages over alternative treatments;
| | - |  | ------------------------------------------------------------------



| |  |  | strength of marketing and distribution support;
| | - |  | -----------------------------------------------



| |  |  | price of vosaroxin, both in absolute terms and relative to alternative treatments; and
| | - |  | --------------------------------------------------------------------------------------



| |  |  | availability of reimbursement from health maintenance organizations and other third-party payors.
| | - |  | -------------------------------------------------------------------------------------------------

For example, the potential toxicity of single and repeated doses of vosaroxin has been explored in a number of animal studies that
suggest the dose-limiting toxicities in humans receiving vosaroxin may be similar to some of those observed with approved cytotoxic agents, including reversible toxicity to bone marrow cells, the gastrointestinal system and other systems with
rapidly dividing cells. In our Phase 1 and Phase 2 clinical trials of vosaroxin, we have witnessed the following side effects, irrespective of causality, ranging from mild to more severe: lowered white blood cell count that may lead to a serious or
possibly life-threatening infection, hair loss, mouth sores, fatigue, nausea with or without vomiting, lowered platelet count, which may lead to an increase in bruising or bleeding, lowered red blood cell count (anemia), weakness, tiredness,
shortness of breath, diarrhea and intestinal blockage.

If vosaroxin fails to achieve market acceptance, due to unacceptable
side effects or any other reasons, we may not be able to generate significant revenue or to achieve or sustain profitability.

Even if we receive regulatory approval for vosaroxin, we will be subject to ongoing FDA and other regulatory obligations and
continued regulatory review, which may result in significant additional expense and limit our ability to commercialize vosaroxin.

Any regulatory approvals that we or our potential future collaboration partners receive for vosaroxin or our future product candidates, if any, may also be subject to limitations on the indicated uses for
which the product may be marketed or contain requirements for potentially costly post-marketing trials. In addition, even if approved, the labeling, packaging, adverse event reporting, storage, advertising, promotion and recordkeeping for any
product will be subject to extensive and ongoing regulatory requirements. The subsequent discovery of previously unknown problems with a product, including adverse events of unanticipated severity or frequency, may result in restrictions on the
marketing of the product, and could include withdrawal of the product from the market.

Regulatory policies may change and
additional government regulations may be enacted that could prevent or delay regulatory approval of our product candidates. We cannot predict the likelihood, nature or extent of government regulation that may arise from future legislation or
administrative action, either in the United States or abroad. If we are not able to maintain regulatory compliance, we might not be permitted to market vosaroxin or our future products and we may not achieve or sustain profitability.



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The coverage and reimbursement status of newly approved drugs is uncertain, and
failure to obtain adequate coverage and reimbursement could limit our ability to market vosaroxin and decrease our ability to generate revenue.

There is significant uncertainty related to the third party coverage and reimbursement of newly approved drugs both nationally and internationally. The commercial success of vosaroxin and our future
products, if any, in both domestic and international markets depends on whether third-party coverage and reimbursement is available for the ordering of our future products by the medical profession for use by their patients. Medicare, Medicaid,
health maintenance organizations and other third-party payors are increasingly attempting to manage healthcare costs by limiting both coverage and the level of reimbursement of new drugs and, as a result, they may not cover or provide adequate
payment for our future products. These payors may not view our future products as cost-effective, and reimbursement may not be available to consumers or may not be sufficient to allow our future products to be marketed on a competitive basis.
Likewise, legislative or regulatory efforts to control or reduce healthcare costs or reform government healthcare programs could result in lower prices or rejection of our future products. Changes in coverage and reimbursement policies or healthcare
cost containment initiatives that limit or restrict reimbursement for our future products may reduce any future product revenue.

Failure to obtain regulatory approval in foreign jurisdictions will prevent us from marketing vosaroxin abroad.

We intend to market vosaroxin in international markets. In order to market vosaroxin in the European Union, Canada and many other foreign jurisdictions, we must obtain separate regulatory approvals. We
have had limited interactions with foreign regulatory authorities, and the approval procedures vary among countries and can involve additional testing at significant cost. The time required to obtain approval may differ from that required to obtain
FDA approval. Approval by the FDA does not ensure approval by regulatory authorities in other countries, and approval by one foreign regulatory authority does not ensure approval by regulatory authorities in other foreign countries or by the FDA.
The foreign regulatory approval processes may include all of the risks associated with obtaining FDA approval. We may not obtain foreign regulatory approvals on a timely basis, if at all. We may not be able to file for regulatory approvals and may
not receive necessary approvals to commercialize vosaroxin or any other future products in any market.

Foreign
governments often impose strict price controls, which may adversely affect our future profitability.

We intend to
seek approval to market vosaroxin in both the United States and foreign jurisdictions. If we obtain approval in one or more foreign jurisdictions, we will be subject to rules and regulations in those jurisdictions relating to vosaroxin. In some
foreign countries, particularly in the European Union, prescription drug pricing is subject to governmental control. In these countries, pricing negotiations with governmental authorities can take considerable time after the receipt of marketing
approval for a drug candidate. To obtain reimbursement or pricing approval in some countries, we may be required to conduct a clinical trial that compares the cost-effectiveness of vosaroxin to other available therapies. If reimbursement of
vosaroxin is unavailable or limited in scope or amount, or if pricing is set at unsatisfactory levels, we may be unable to achieve or sustain profitability.

We may incur significant costs complying with environmental laws and regulations, and failure to comply with these laws and regulations could expose us to significant liabilities.

We, through third-party contractors, use hazardous chemicals and radioactive and biological materials in our business
and are subject to a variety of federal, state, regional and local laws and regulations governing the use, generation, manufacture, storage, handling and disposal of these materials. Although we believe our safety procedures for handling and
disposing of these materials and waste products comply with these laws and regulations, we cannot eliminate the risk of accidental injury or contamination from the use, storage, handling or



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disposal of hazardous materials. In the event of contamination or injury, we could be held liable for any resulting damages, and any liability could significantly exceed our insurance coverage,
which is limited for pollution cleanup and contamination.

Risks Related to Our Common Stock

The price of our common stock may continue to be volatile, and the value of an investment in our common stock may
decline.

In 2010, our common stock traded as low as $1.75 and as high as $9.72. Factors that could cause continued
volatility in the market price of our common stock include, but are not limited to:



| |  |  | our ability to raise additional capital to carry through with our clinical development plans and current and future operations and the terms of any
related financing arrangement;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | results from, and any delays in or discontinuance of, ongoing and planned clinical trials for vosaroxin;
| | - |  | --------------------------------------------------------------------------------------------------------



| |  |  | an expansion of the number of patients included in the VALOR trial based on the pre-specified interim analysis by the DSMB;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------



| |  |  | announcements of FDA non-approval of vosaroxin, delays in filing regulatory documents with the FDA or other regulatory agencies, or delays in the
review process by the FDA or other foreign regulatory agencies;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | announcements relating to restructuring and other operational changes;
| | - |  | ----------------------------------------------------------------------



| |  |  | delays in the commercialization of vosaroxin or our future products, if any;
| | - |  | ----------------------------------------------------------------------------



| |  |  | market conditions in the pharmaceutical, biopharmaceutical and biotechnology sectors;
| | - |  | -------------------------------------------------------------------------------------



| |  |  | issuance of new or changed securities analysts reports or recommendations;
| | - |  | ---------------------------------------------------------------------------



| |  |  | developments or disputes concerning our intellectual property or other proprietary rights;
| | - |  | ------------------------------------------------------------------------------------------



| |  |  | clinical and regulatory developments with respect to potential competitive products;
| | - |  | ------------------------------------------------------------------------------------



| |  |  | introduction of new products by our competitors;
| | - |  | ------------------------------------------------



| |  |  | issues in manufacturing vosaroxin drug substance or drug product, or future products, if any;
| | - |  | ---------------------------------------------------------------------------------------------



| |  |  | market acceptance of vosaroxin or our future products, if any;
| | - |  | --------------------------------------------------------------



| |  |  | announcements relating to our collaboration with Biogen Idec;
| | - |  | -------------------------------------------------------------



| |  |  | actual and anticipated fluctuations in our quarterly operating results;
| | - |  | -----------------------------------------------------------------------



| |  |  | deviations in our operating results from the estimates of analysts;
| | - |  | -------------------------------------------------------------------



| |  |  | third-party healthcare reimbursement policies;
| | - |  | ----------------------------------------------



| |  |  | FDA or other U.S. or foreign regulatory actions affecting us or our industry;
| | - |  | -----------------------------------------------------------------------------



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| |  |  | litigation or public concern about the safety of vosaroxin or future products, if any;
| | - |  | --------------------------------------------------------------------------------------



| |  |  | failure to develop or sustain an active and liquid trading market for our common stock;
| | - |  | ---------------------------------------------------------------------------------------



| |  |  | sales of our common stock by our officers, directors or significant stockholders; and
| | - |  | -------------------------------------------------------------------------------------



| |  |  | additions or departures of key personnel.
| | - |  | -----------------------------------------

If we fail to maintain compliance with the continued listing requirements of The NASDAQ Capital Market, our common stock may be delisted and the price of our common stock and our ability to access
the capital markets could be negatively impacted.

Our common stock currently trades on The NASDAQ Capital Market under
the symbol SNSS. This market has continued listing standards that we must comply with in order to maintain the listing of our common stock. The continued listing standards include, among others, a minimum bid price requirement of $1.00
per share and any of: (i) a minimum stockholders equity of $2.5 million; (ii) a market value of listed securities of at least $35.0 million; or (iii) net income from continuing operations of $500,000 in the most recently
completed fiscal year or in the two of the last three fiscal years. Our results of operations and fluctuating stock price directly impact our ability to satisfy these continued listing standards. In the event we are unable to maintain these
continued listing standards, our common stock may be subject to delisting from The NASDAQ Capital Market.

From March 31,
2010 until the close of trading on March 1, 2011, we were not in compliance with the minimum bid price requirement of $1.00 per share pursuant to NASDAQ Listing Rule 5550(a)(2). On February 14, 2011, we effected a one-for-six reverse split
of our capital stock, or the Reverse Split, as previously authorized and approved at our annual meeting of stockholders on June 2, 2010. As a result of the Reverse Split, every six shares of our capital stock were combined into one share of
capital stock. On February 15, 2011, our common stock began trading on The NASDAQ Capital Market on a post-Reverse Split basis, following which the bid price of our common stock closed at or above $1.00 for the 10 consecutive business days
ended March 1, 2011. As a result, on March 2, 2011, we received a letter from NASDAQ indicating that we had regained compliance with the rule as the closing bid price of our common stock had been at $1.00 per share or greater for 10
consecutive trading days. As a result, we are currently in full compliance with the NASDAQ continued listing requirements.

As
mentioned above, the price of our common stock can be volatile, and there can be no assurance that we will continue to meet the minimum $1.00 bid price requirement or the other NASDAQ continued listing requirements in the future, and we may be
subject to delisting as a result. If we are delisted, we would expect our common stock to be traded in the over-the-counter market, which could adversely affect the liquidity of our common stock. Additionally, we could face significant material
adverse consequences, including:



| |  |  | a limited availability of market quotations for our common stock;
| | - |  | -----------------------------------------------------------------



| |  |  | a reduced amount of analyst coverage for us;
| | - |  | --------------------------------------------



| |  |  | a decreased ability to issue additional securities or obtain additional financing in the future;
| | - |  | ------------------------------------------------------------------------------------------------



| |  |  | reduced liquidity for our stockholders;
| | - |  | ---------------------------------------



| |  |  | potential loss of confidence by collaboration partners and employees; and
| | - |  | -------------------------------------------------------------------------



| |  |  | loss of institutional investor interest.
| | - |  | ----------------------------------------



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Provisions of our charter documents or Delaware law could delay or prevent an
acquisition of our company, even if the acquisition would be beneficial to our stockholders, and could make it more difficult to change management.

Provisions of our amended and restated certificate of incorporation and amended and restated bylaws may discourage, delay or prevent a merger, acquisition or other change in control that stockholders
might otherwise consider favorable, including transactions in which stockholders might otherwise receive a premium for their shares. In addition, these provisions may frustrate or prevent any attempt by our stockholders to replace or remove our
current management by making it more difficult to replace or remove our board of directors. These provisions include:



| |  |  | a classified board of directors so that not all directors are elected at one time;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | a prohibition on stockholder action through written consent;
| | - |  | ------------------------------------------------------------



| |  |  | limitations on our stockholders ability to call special meetings of stockholders;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | an advance notice requirement for stockholder proposals and nominations; and
| | - |  | ----------------------------------------------------------------------------



| |  |  | the authority of our board of directors to issue preferred stock with such terms as our board of directors may determine.
| | - |  | -------------------------------------------------------------------------------------------------------------------------

In addition, Delaware law prohibits a publicly held Delaware corporation from engaging in a business combination with an interested
stockholder, generally a person who, together with its affiliates, owns or within the last three years has owned 15% of our voting stock, for a period of three years after the date of the transaction in which the person became an interested
stockholder, unless the business combination is approved in a prescribed manner. Accordingly, Delaware law may discourage, delay or prevent a change in control of our company.

Provisions in our charter documents and provisions of Delaware law could limit the price that investors are willing to pay in the future for shares of our common stock.

The ownership of our capital stock is highly concentrated, and your interests may conflict with the interests of our existing
stockholders.

Our executive officers and directors and their affiliates beneficially owned approximately 34.7% of our
outstanding capital stock as of December 31, 2010, assuming the exercise in full of the outstanding warrants to purchase common stock held by these stockholders as of such date. Accordingly, these stockholders, acting as a group, could have
significant influence over the outcome of corporate actions requiring stockholder approval, including the election of directors, any merger, consolidation or sale of all or substantially all of our assets or any other significant corporate
transaction. The significant concentration of stock ownership may adversely affect the trading price of our common stock due to investors perception that conflicts of interest may exist or arise.

We have never paid dividends on our capital stock and we do not anticipate paying any cash dividends in the foreseeable future.

We have never declared or paid cash dividends on our capital stock. We do not anticipate paying any cash dividends on
our capital stock in the foreseeable future. We currently intend to retain all available funds and any future earnings to fund the development and growth of our business. As a result, capital appreciation, if any, of our common stock will be our
stockholders sole source of gain for the foreseeable future.



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We are at risk of securities class action litigation.

In the past, securities class action litigation has often been brought against a company following a decline in the market price of its
securities. This risk is especially relevant for us because biotechnology companies have experienced greater than average stock price volatility in recent years. These broad market fluctuations may adversely affect the trading price or liquidity of
our common stock. In the past, when the market price of a stock has been volatile, holders of that stock have sometimes instituted securities class action litigation against the issuer. If any of our stockholders were to bring such a lawsuit against
us, we could incur substantial costs defending the lawsuit and the attention of our management would be diverted from the operation of our business.



|ITEM 1B. | UNRESOLVED STAFF COMMENTS
|-------- | -------------------------

None.



|ITEM 2. | PROPERTIES
|------- | ----------

In December 2006, we leased 15,000 square feet of office space in a building at 395 Oyster Point Boulevard in South San Francisco, California, which is currently our corporate headquarters. This lease
expires in April 2013, subject to our option to extend the lease through February 2014. In October 2008, we leased 5,500 square feet of laboratory space at 349 Allerton Avenue, South San Francisco, California. This lease expired in October 2010 and
we did not exercise our option to extend the lease. We believe that our current facility will be sufficient to meet our needs through at least 2011.



|ITEM 3. | LEGAL PROCEEDINGS
|------- | -----------------

From time to time, we may be involved in routine legal proceedings, as well as demands, claims and threatened litigation, which arise in the normal course of our business. The ultimate outcome of any
litigation is uncertain and unfavorable outcomes could have a negative impact on our results of operations and financial condition. Regardless of outcome, litigation can have an adverse impact on us because of the defense costs, diversion of
management resources and other factors.

We believe there is no litigation pending that could, individually or in the
aggregate, have a material adverse effect on our results of operations or financial condition.



|ITEM 4. | (REMOVED AND RESERVED)
|------- | ----------------------



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PART II



|ITEM 5. | MARKET FOR REGISTRANTS COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES
|------- | ------------------------------------------------------------------------------------------------------------

Our common stock is listed on The NASDAQ Capital Market under the symbol SNSS. From our initial public offering on
September 27, 2005 until August 3, 2009 our common stock was listed on The NASDAQ Global Market under the same symbol. The following table sets forth the range of the high and low sales prices by quarter, as reported by NASDAQ, after
giving retroactive effect to the one-for-six reverse split of shares of our capital stock, or the Reverse Split, outstanding immediately prior to the effective time of the Reverse Split on February 14, 2011.



|                             |  |      |       |  |     |   |      | 
|---------------------------- |  | ---- | ----- |  | --- | - | ---- | 
|Year-Ended December 31, 2009 |  | High |       |  | Low |  
|First Quarter                |  | $    | 3.03  |  |     | $ | 0.96 | 
|Second Quarter               |  | $    | 5.40  |  |     | $ | 0.30 | 
|Third Quarter                |  | $    | 3.36  |  |     | $ | 1.57 | 
|Fourth Quarter               |  | $    | 14.58 |  |     | $ | 1.62 | 
|                             |  |     
|Year-Ended December 31, 2010 |  | High |       |  | Low |  
|First Quarter                |  | $    | 9.72  |  |     | $ | 4.26 | 
|Second Quarter               |  | $    | 7.38  |  |     | $ | 2.64 | 
|Third Quarter                |  | $    | 3.30  |  |     | $ | 2.22 | 
|Fourth Quarter               |  | $    | 3.69  |  |     | $ | 1.75 | 

As of
February 18, 2011, there were approximately 179 holders of record of our common stock. In addition, we believe that a significant number of beneficial owners of our common stock hold their shares in nominee or in street name
accounts through brokers. On March 15, 2011, the last sale price reported on The NASDAQ Capital Market for our common stock was $1.88 per share.

Dividend Policy

We have never paid cash dividends on our common
stock. We do not anticipate paying any cash dividends on our capital stock in the foreseeable future. While subject to periodic review, the current policy of our board of directors is to retain cash and investments primarily to provide funds for our
future growth.

Unregistered Sales of Equity Securities

In March 2009, we entered into a securities purchase agreement with accredited investors, including certain members of management,
providing for the private placement of up to $15.0 million of units consisting of Series A convertible preferred stock and warrants to purchase common stock, and up to $28.5 million in common stock, in three closings, or the Private Placement. On
April 3, 2009, we sold $10.0 million of units consisting of shares of our Series A convertible preferred stock and warrants to purchase our common stock in the initial closing of the Private Placement. On October 30, 2009, we sold $5.0
million of units in the second closing. On June 30, 2010, we sold $28.5 million of common stock in the third and final closing of the Private Placement. Aggregate net proceeds from the Private Placement were $40.1 million. The sales were to
accredited investors, including certain members of management, and were exempt from the registration requirements of the Securities Act of 1933, as amended, pursuant to Rule 506 of Regulation D promulgated thereunder.

In connection with the initial closing, we issued 483,081 shares of Series A convertible preferred stock to the investors, which were
initially convertible into 4,830,901 shares of common stock, and warrants to purchase 4,830,901 shares of common stock. In connection with the second closing, we issued 241,537 shares of Series A convertible preferred stock to the investors, which
were initially convertible into 2,415,438 shares of common



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stock, and warrants to purchase 2,415,438 shares of common stock. The warrants to purchase common stock may be exercised at the election of the holder at any time during their term of seven years
from the date of issuance. During the year ended December 31, 2010, a total of 1,764,322 shares of common stock were issued upon the exercise of warrants issued in the Private Placement. As of March 15, 2011, 4,592,123 shares of common
stock remained available for issuance upon the exercise of warrants issued in the Private Placement.

In connection with the
third and final closing of the Private Placement, we issued 17,272,716 shares of common stock to the investors at a purchase price of $1.65 per share. In conjunction with this closing, each of the outstanding shares of Series A convertible
preferred stock issued in the initial and second closings of the Private Placement was converted into 10 shares of common stock, and as a result, an additional 7,246,339 shares of common stock were issued on June 30, 2010.

We have used, and expect to use, the aggregate net proceeds of $40.1 million for working capital and other general corporate purposes.



|ITEM 6. | SELECTED FINANCIAL DATA
|------- | -----------------------

The following selected financial data should be read in conjunction with Managements Discussion and Analysis of Financial Condition and Results of Operations and our consolidated
financial statements and notes to those statements included elsewhere in this report.



|                                                                                                     |  |                                                     |            |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  
|---------------------------------------------------------------------------------------------------- |  | --------------------------------------------------- | ---------- | - | ---- | - | --------- | ---- |  | - | --------- | - |  | ---- | --------- | - |  | - | --------- | -
|                                                                                                     |  | Year Ended December 31,                             |           
|Consolidated Statement of Operations:                                                                |  | 2010                                                |            |   | 2009 |   |           | 2008 |  |   | 2007      |   |  | 2006 |          
|                                                                                                     |  | (In thousands, except shares and per share amounts) |           
|Revenue:                                                                                             |  |                                                     |            |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  
|Collaboration revenue                                                                                |  | $                                                   | 27         |   |      | $ | 1,550     |      |  | $ | 4,917     |   |  | $    | 9,163     |   |  | $ | 13,671    |  
|License and other revenue                                                                            |  |                                                     | 6          |   |      |   | 2,212     |      |  |   | 500       |   |  |      | 500       |   |  |   | 38        |  
|                                                                                                     |  |                                                     |            |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  
|Total revenues                                                                                       |  |                                                     | 33         |   |      |   | 3,762     |      |  |   | 5,417     |   |  |      | 9,663     |   |  |   | 13,709    |  
|                                                                                                     |  |                                                     |            |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  
|Operating expenses:                                                                                  |  |                                                     |            |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  
|Research and development                                                                             |  |                                                     | 14,434     |   |      |   | 13,247    |      |  |   | 26,285    |   |  |      | 36,060    |   |  |   | 35,615    |  
|General and administrative                                                                           |  |                                                     | 7,005      |   |      |   | 7,748     |      |  |   | 11,524    |   |  |      | 13,570    |   |  |   | 12,255    |  
|Restructuring charges                                                                                |  |                                                     |           |   |      |   | 1,916     |      |  |   | 5,783     |   |  |      | 1,563     |   |  |   |          |  
|                                                                                                     |  |                                                     |            |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  
|Total operating expenses                                                                             |  |                                                     | 21,439     |   |      |   | 22,911    |      |  |   | 43,592    |   |  |      | 51,193    |   |  |   | 47,870    |  
|                                                                                                     |  |                                                     |            |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  
|Loss from operations                                                                                 |  |                                                     | (21,406    | ) |      |   | (19,149   | )    |  |   | (38,175   | ) |  |      | (41,530   | ) |  |   | (34,161   | )
|Other income (expense), net(1)                                                                       |  |                                                     | (3,181     | ) |      |   | (21,077   | )    |  |   | 989       |   |  |      | 2,769     |   |  |   | 2,924     |  
|                                                                                                     |  |                                                     |            |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  
|Net loss                                                                                             |  |                                                     | (24,587    | ) |      |   | (40,226   | )    |  |   | (37,186   | ) |  |      | (38,761   | ) |  |   | (31,237   | )
|Deemed distribution to preferred stockholders(2)                                                     |  |                                                     |           |   |      |   | (27,563   | )    |  |   |          |   |  |      |          |   |  |   |          |  
|                                                                                                     |  |                                                     |            |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  
|Loss attributable to common stockholders                                                             |  | $                                                   | (24,587    | ) |      | $ | (67,789   | )    |  | $ | (37,186   | ) |  | $    | (38,761   | ) |  | $ | (31,237   | )
|                                                                                                     |  |                                                     |            |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  
|Basic and diluted loss attributable to common stockholders per common share                          |  | $                                                   | (0.99      | ) |      | $ | (11.80    | )    |  | $ | (6.49     | ) |  | $    | (7.19     | ) |  | $ | (6.75     | )
|                                                                                                     |  |                                                     |            |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  
|Shares used in computing basic and diluted loss attributable to common stockholders per common share |  |                                                     | 24,860,212 |   |      |   | 5,746,786 |      |  |   | 5,731,196 |   |  |      | 5,390,034 |   |  |   | 4,626,391 |  
|                                                                                                     |  |                                                     |            |   |      |   |           |      |  |   |           |   |  |      |           |   |  |   |           |  



|(1) | In December 2010, we recorded a non-cash charge of $3.7 million to revalue the liability for warrants issued in connection with the underwritten offering in October
2010 (see Note 9 of the accompanying consolidated financial statements).
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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During 2009, we recorded non-cash charges of $21.0 million related to the accounting for the
fair values of securities issued as part of the Private Placement (see Note 9 of the accompanying consolidated financial statements). The non-cash charges consisted of $7.5 million recorded upon the initial closing of $10.0 million of units in April
2009 and $13.5 million upon the revaluation in June 2009 of the options to participate in the second closing of $5.0 million of units and the third closing of up to $28.5 million of common stock, which occurred in October 2009 and June 2010,
respectively.



|(2) | During 2009, we recorded deemed distributions to preferred stockholders totaling $27.6 million, related to the accounting for the Private Placement. Of this amount,
$26.4 million was due to the revaluation of certain securities upon an amendment of the Private Placement agreements in June 2009, and $1.2 million was due to the write-off of a discount for a beneficial conversion feature on the convertible
preferred stock issued as part of the second closing of the Private Placement in October 2009.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|                                                 |  |                    |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|------------------------------------------------ |  | ------------------ | -------- | - | ---- | - | -------- | ---- |  | - | -------- | - |  | ---- | -------- | - |  | - | -------- | -
|                                                 |  | As of December 31, |         
|Consolidated Balance Sheet Data:                 |  | 2010               |          |   | 2009 |   |          | 2008 |  |   | 2007     |   |  | 2006 |         
|                                                 |  | (In thousands)     |         
|Cash, cash equivalents and marketable securities |  | $                  | 53,396   |   |      | $ | 4,259    |      |  | $ | 10,619   |   |  | $    | 47,684   |   |  | $ | 63,105   |  
|Working capital                                  |  |                    | 42,118   |   |      |   | 1,807    |      |  |   | 5,371    |   |  |      | 39,707   |   |  |   | 55,279   |  
|Total assets                                     |  |                    | 54,858   |   |      |   | 5,169    |      |  |   | 12,784   |   |  |      | 53,246   |   |  |   | 69,276   |  
|Long-term portion of equipment leases            |  |                    |         |   |      |   |         |      |  |   |         |   |  |      | 1,353    |   |  |   | 956      |  
|Convertible preferred stock                      |  |                    |         |   |      |   | 60,005   |      |  |   |         |   |  |      |         |   |  |   |         |  
|Common stock and additional paid-in capital      |  |                    | 423,267  |   |      |   | 298,473  |      |  |   | 322,675  |   |  |      | 320,583  |   |  |   | 298,077  |  
|Accumulated deficit                              |  |                    | (381,005 | ) |      |   | (356,418 | )    |  |   | (316,192 | ) |  |      | (279,006 | ) |  |   | (240,245 | )
|Total stockholders equity                       |  |                    | 42,247   |   |      |   | 2,060    |      |  |   | 6,491    |   |  |      | 41,394   |   |  |   | 56,804   |  



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|ITEM 7. | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
|------- | -------------------------------------------------------------------------------------

The following discussion and analysis of our financial condition as of December 31, 2010 and results of operations for the year
ended December 31, 2010 should be read together with our consolidated financial statements and related notes included elsewhere in this report. This discussion and analysis contains forward-looking statements within the meaning of
Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, that involve risks, uncertainties and assumptions. All statements, other than statements of historical facts, are
forward-looking statements for purposes of these provisions, including without limitation any statements relating to our strategy, including our plans with respect to presenting clinical data and initiating clinical trials, our future
research and development activities, including clinical testing and the costs and timing thereof, sufficiency of our cash resources, our ability to raise additional funding when needed, any statements concerning anticipated regulatory activities or
licensing or collaborative arrangements, our research and development and other expenses, our operations and legal risks, and any statement of assumptions underlying any of the foregoing. In some cases, forward-looking statements can be identified
by the use of terminology such as anticipates, believe, continue, estimates, expects, intend, look forward, may, could, seeks,
plans, potential, or will or the negative thereof or other comparable terminology. Although we believe that the expectations reflected in the forward-looking statements contained herein are reasonable, there can
be no assurance that such expectations or any of the forward-looking statements will prove to be correct, and actual results could differ materially from those projected or assumed in the forward-looking statements. Our actual results may differ
materially from those anticipated in these forward-looking statements as a result of many factors, including but not limited to those set forth under Risk Factors, and elsewhere in this report. We urge you not to place undue reliance on
these forward-looking statements, which speak only as of the date of this report. All forward-looking statements included in this report are based on information available to us on the date of this report, and we assume no obligation to update any
forward-looking statements contained in this report.

Overview

We are a biopharmaceutical company focused on the development and commercialization of new oncology therapeutics for the treatment of
hematologic and solid tumor cancers. Our efforts are currently focused primarily on the development of vosaroxin (formerly voreloxin) for the treatment of acute myeloid leukemia, or AML. We have built a highly experienced cancer drug
development organization committed to advancing our lead product candidate, vosaroxin, in multiple indications to improve the lives of people with cancer.

Vosaroxin is a first-in-class anti-cancer quinolone derivative, or AQDa class of compounds that has not been used previously for the treatment of cancer. Quinolone derivatives have been shown
to mediate anti-tumor activity by targeting mammalian topoisomerase II, an enzyme critical for cell replication. We own worldwide development and commercialization rights to vosaroxin.

In December 2010, we commenced enrollment of a Phase 3, multi-national, randomized, double-blind, placebo-controlled, pivotal trial of
vosaroxin in combination with cytarabine in patients with relapsed or refractory AML, or the VALOR trial. The VALOR trial is designed to evaluate the effect of vosaroxin in combination with cytarabine, a widely used chemotherapy in AML, on overall
survival as compared to placebo in combination with cytarabine. The trial design is based on data from our Phase 2 clinical trial of vosaroxin in combination with cytarabine in first relapsed or primary refractory AML, together with guidance
received from both U.S. and European regulatory agencies.

With an anticipated 450 evaluable patients, the trial is designed
to have a 90% probability of detecting a 40% difference in overall survival. The trial includes a single pre-specified interim analysis by the independent Data Safety Monitoring Board, or DSMB, that may recommend a one-time sample size adjustment of
225 additional evaluable patients if deemed beneficial by the DSMB to maintain adequate power across a range of



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clinically meaningful and statistically significant survival outcomes. In February 2011, the FDA granted fast track designation to vosaroxin for the potential treatment of relapsed or refractory
AML in combination with cytarabine.

We are also in the survival follow-up stage of two fully-enrolled clinical trials of
vosaroxin: (a) the Phase 2 portion of a Phase 1b/2 trial of vosaroxin in combination with cytarabine for the treatment of patients with first relapsed or primary refractory AML, and (b) a Phase 2 trial (known as REVEAL-1) in
previously untreated elderly patients with AML, which explored three different dose schedules. In addition, we completed a Phase 2 single agent trial of vosaroxin in platinum-resistant ovarian cancer patients in 2010, which explored three
different dose cohorts. The most recent data from the AML studies were presented at the Chemotherapy Foundation Symposium XXVIII in November 2010, and the most recent data from the ovarian cancer study were presented at the American Society of
Clinical Oncology 2010 Annual Meeting in June 2010.

In 2009, the U.S. Food and Drug Administration, or FDA, granted orphan
drug designation to vosaroxin for the treatment of AML. In July 2010, we announced that the European Patent Office, or EPO, had granted us a patent covering combinations of vosaroxin with cytarabine. The patent provides coverage to 2025 for such
combination products in 30 member states of the European Patent Convention. In November 2010, we announced that the U.S. Patent and Trademark Office had granted us a patent covering pharmaceutical compositions of vosaroxin, and in March 2011, we
announced that the EPO had granted us a similar patent, which we are proceeding to validate in multiple EPO member states. These patents cover the formulation used in our VALOR trial and extend vosaroxins patent life to 2025. Related patent
applications are pending in other major markets throughout the world, including Japan, Australia and Canada.

Recent Financial History

In March 2009, we entered into a securities purchase agreement with accredited investors, including certain members of
management, providing for the private placement of up to $15.0 million of units consisting of Series A convertible preferred stock and warrants to purchase common stock, and up to $28.5 million in common stock, in three closings, or the Private
Placement. We completed the initial closing of $10.0 million in April 2009, resulting in net proceeds of $8.8 million, and the second closing of $5.0 million in October 2009, for net proceeds of $4.7 million. In June 2010, we completed the third and
final closing of the Private Placement, issuing 17.3 million shares of common stock to the investors at a purchase price of $1.65 per share, for net proceeds of $26.7 million. In conjunction with this closing, each of the 0.7 million
outstanding shares of Series A convertible preferred stock issued in the initial and second closings of the Private Placement was converted into 10 shares of common stock, and as a result, 7.2 million shares of common stock were issued in
June 2010.

In January 2010, we entered into our first controlled equity offering sales agreement with Cantor
Fitzgerald & Co., or Cantor, pursuant to which we could issue and sell shares of our common stock having an aggregate offering price of up to $15.0 million from time to time through Cantor acting as agent and/or principal, subject to
certain conditions. Under this facility, we sold an aggregate of 2.6 million shares of common stock in 2010 at an average price of $5.67 per share for gross proceeds of $15.0 million. Net proceeds were $14.2 million after deducting
Cantors commission and costs to set up the facility. No further shares of common stock can be issued under this facility.

In April 2010, we entered into a second controlled equity offering sales agreement with Cantor, pursuant to which we may issue and sell shares of our common stock having an aggregate offering price of up
to $20.0 million from time to time through Cantor acting as agent and/or principal. As of March 15, 2011, we had sold an aggregate of 3.7 million shares of common stock at an average price of $4.32 per share for gross proceeds of $16.0
million. Net proceeds were $15.4 million after deducting Cantors commission and costs to set up the facility. As of March 15, 2011, $4.0 million of common stock was available to be sold under this facility, subject to certain
conditions as specified in the agreement.



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In October 2010, we completed an underwritten offering, pursuant to which we issued an
aggregate of 7.4 million shares of our common stock and warrants to purchase 3.7 million shares of our common stock, for aggregate gross proceeds of $15.5 million, or the 2010 Offering. Net proceeds from the sale were $14.2 million, after
deducting the underwriting discount and offering expenses. The warrants are exercisable beginning six months after issuance at an exercise price of $2.52 per share, and expire five years from the date of issuance.

On February 14, 2011, we effected a one-for-six reverse split of our capital stock, or the Reverse Split, as previously authorized
and approved at our annual meeting of stockholders on June 2, 2010. As a result of the Reverse Split, every six shares of our capital stock were combined into one share of capital stock. The Reverse Split affected all our common stock
outstanding immediately prior to the effective time of the Reverse Split as well as the number of shares of common stock available for issuance under our equity incentive plans. In addition, the Reverse Split effected a reduction in the number of
shares of common stock issuable upon the exercise of outstanding stock options and warrants. Immediately following the Reverse Split, 45,989,737 shares of our common stock were outstanding. All share and per share amounts in this Annual Report on
Form 10-K have been adjusted to give effect to the Reverse Split.

We have incurred significant losses in each year since our
inception. As of December 31, 2010, we had cash, cash equivalents and marketable securities of $53.4 million and an accumulated deficit of $381.0 million. We expect to continue to incur significant losses for the foreseeable future, as we
continue the development of, and seek regulatory approvals for vosaroxin.

On March 31, 2010, we received a letter from
the NASDAQ Listing Qualifications Staff, or the Staff, notifying us that we did not comply with the minimum $1.00 per share closing bid price requirement, or the Bid Price Requirement, for a continued listing on The NASDAQ Capital Market. In
accordance with NASDAQ Listing Rules, we were given until September 27, 2010 to regain compliance. On September 28, 2010, we received a second letter from the Staff notifying us of its determination that we had failed to regain compliance
with the Bid Price Requirement by September 27, 2010, but that we met all other initial inclusion criteria for The NASDAQ Capital Market set forth in NASDAQ Listing Rule 5505. As a result, in accordance with NASDAQ Listing Rules, we were
granted an additional 180 calendar days, or until March 28, 2011, to regain compliance. To regain compliance, the bid price of our common stock needed to close at or above $1.00 for at least 10 consecutive business days at any time prior to
March 28, 2011. Our common stock began trading on The NASDAQ Capital Market on a post-Reverse Split basis on February 15, 2011. Subsequently, the bid price of our common stock closed at or above $1.00 for the 10 consecutive business days
ended March 1, 2011, and on March 2, 2011, we received a letter from NASDAQ notifying us that we had regained compliance with the Bid Price Requirement.

Capital Requirements

While we believe that we currently have the
resources available and accessible to fund our operations until the planned unblinding of the VALOR trial in 2013, we will need to raise substantial additional capital to complete development and the potential commercialization of vosaroxin. To the
extent that the costs of the VALOR trial exceed our current estimates, unblinding does not occur within the currently anticipated timeframe or we are unable to raise sufficient additional capital through our controlled equity offering facility or
otherwise, we will need to reduce operating expenses, enter into a collaboration or other similar arrangement with respect to development and/or commercialization rights to vosaroxin, outlicense intellectual property rights to vosaroxin, sell
assets, or a combination of the above. We will also need to raise substantial additional capital if we expand the number of patients included in the trial based on the pre-specified interim analysis of data from the trial by the DSMB. In addition,
we will need to raise substantial additional capital to complete the development and potential commercialization of vosaroxin.

We expect to finance our future cash needs primarily through equity issuances, debt arrangements, a possible license, collaboration or
other similar arrangement with respect to development and/or



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commercialization rights to vosaroxin, or a combination of the above. However, we do not know whether additional funding will be available on acceptable terms, or at all. If we are unable to
raise substantial additional funding on acceptable terms or at all, we will be forced to delay or reduce the scope of our vosaroxin development program, potentially including the VALOR trial, and/or limit or cease our operations.

Critical Accounting Policies and the Use of Estimates

The accompanying discussion and analysis of our financial condition and results of operations are based on our consolidated financial statements and the related disclosures, which have been prepared in
accordance with U.S. generally accepted accounting principles. The preparation of these consolidated financial statements requires our management to make estimates, assumptions and judgments that affect the amounts reported in our financial
statements and accompanying notes, including reported amounts of assets, liabilities and expenses and the disclosure of contingent assets and liabilities at the date of the consolidated financial statements, as well as revenue and expenses during
the reporting periods. We evaluate our estimates, assumptions and judgments on an ongoing basis. We base our estimates on historical experience and on various other assumptions we believe are reasonable under the circumstances, the results of which
form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Management has discussed the development, selection and disclosure of these estimates with the Audit Committee
of our Board of Directors. Actual results could differ materially from these estimates under different assumptions or conditions.

Our significant accounting policies are more fully described in Note 1 to our consolidated financial statements included elsewhere in this report. We believe the following critical accounting
policies reflect our more significant estimates and assumptions used in the preparation of our consolidated financial statements.

Accounting for Equity Financings

The accounting for the initial
and second closing of the sale of $10.0 million and $5.0 million of units, respectively, under our Private Placement, and subsequent revaluations of the related financial instruments, required fair values to be established at different dates, either
individually or in aggregate, for the four primary components of the Private Placement: (a) the Series A convertible preferred stock, (b) the warrants to purchase common stock, (c) the option for the investors to participate in the
second closing, or the Second Closing Option, and (d) the option for the investors to participate in the common equity closing, or the Common Equity Closing Option. The Option-Pricing Method, which utilizes the Black-Scholes model, was selected
to determine these fair values, which were calculated as a series of call options on the potential enterprise value of the company at different valuation points at which the claims of the different stakeholder groups on the enterprise value would
change. The results of the Black-Scholes model were affected by the companys stock price, as well as assumptions regarding a number of highly subjective variables. These variables included the expected term of the financial instruments and our
expected stock price volatility, risk-free interest rate and dividend rate over the expected term. Alternative models could have been selected to calculate these fair values, which may have produced significantly different results.

In October 2010, we completed the 2010 Offering, in which we sold our common stock and warrants to purchase our common stock for
aggregate gross proceeds of $15.5 million. Due to the potential for the warrants to be settled in cash upon the occurrence of certain transactions specified in the warrant agreements, the warrants are being accounted for as a derivative liability as
opposed to permanent equity. Outstanding warrants under this arrangement are revalued to their fair value each period end, with the change in fair value recorded to other income (expense) in the statement of operations. The Black-Scholes model was
selected as the most appropriate method to estimate both the initial and subsequent fair values of the warrants. The determination of initial and subsequent fair values is affected by our stock price as well as assumptions regarding a number of
highly complex and subjective variables, as noted above. Changes in these input variables have, and will continue to, affect the income or expense recorded each period for the revaluation of outstanding warrants. As a result, fluctuations in our
stock price or other input variables may significantly affect our financial results.



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Revenue Recognition

Revenue arrangements with multiple deliverables are accounted for in accordance with Financial Accounting Standards Board Accounting
Standards Codification Subtopic 605-25, Multiple-Element Arrangements, or ASC 605-25. Under ASC 605-25, revenue arrangements with multiple deliverables are divided into separate units of accounting based on whether certain criteria are met,
including whether the delivered item has stand-alone value to the customer and whether there is objective and reliable evidence of the fair value of the undelivered items. Consideration is allocated among the separate units of accounting based on
their respective fair value, and the applicable revenue recognition is applied to each of the separate units.

Non-refundable
fees where we have no continuing performance obligations are recognized as revenues when collection is reasonably assured. In situations where continuing performance obligations exist, nonrefundable fees are deferred and recognized ratably over the
projected performance period.

Research funding from collaborations is recognized as revenue as the related research services
are performed. This funding is generally based on a specified amount per full-time equivalent employee per year.

Milestone
payments which are substantive and at risk at the time of the execution of the collaboration agreement, are recognized upon completion of the applicable milestone event. Any future royalty revenue will be recognized based on reported product sales
by third-party licensees.

Clinical Trial Accounting

We record accruals for estimated clinical trial costs, which include payments for work performed by contract research organizations, or
CROs, and participating clinical trial sites. These costs are generally a significant component of research and development expenses. Costs incurred for setting up clinical trial sites for participation in trials are generally non-refundable, and
are expensed immediately, with any refundable advances related to enrollment of the first patient recorded as prepayments and assessed for recoverability on a quarterly basis. Costs related to patient enrollment are accrued as patients progress
through the clinical trial, including amortization of any first-patient prepayments. This amortization generally matches when the related services are rendered, however, these cost estimates may or may not match the actual costs incurred by the CROs
or clinical trial sites, and if we have incomplete or inaccurate information, our clinical trial accruals may not be accurate. The difference between accrued expenses based on our estimates and actual expenses have not been material to date.

Overview of Revenues

We have not generated any revenue from sales of commercial products and do not expect to generate any product revenue in the foreseeable future.

Collaboration Revenue

Over the past three years, we have generated revenue primarily through collaborations with Biogen Idec, J&JPRD and Merck, consisting principally of research funding and milestones paid by our
collaborators, substantially offsetting our related research and development expenses. Our collaborations with J&JPRD and Merck terminated in January 2010 and June 2010, respectively.

Under our collaboration agreement with Biogen Idec, we may in the future receive pre-commercialization milestone payments of up to $60.5
million per target, as well as royalty payments depending on product sales. Potential total royalty payments may be increased if we exercise our option to co-develop and co-promote product candidates for up to two targets worldwide (excluding
Japan) and may be reduced if Biogen Idec is required to in-license additional intellectual property related to certain technology jointly developed under the collaboration agreement in order to commercialize a collaboration product.



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In November 2010, Biogen Idec announced that it will seek to spin out or outlicense certain
oncology assets, including this collaboration agreement. We cannot predict the outcome of this strategic decision by Biogen Idec or its impact on future development activity under the collaboration agreement or on our prospects for the receipt
of milestone or royalty payments under the collaboration agreement. We expect that a Phase 1 clinical trial will be initiated in 2011 for the Raf kinase inhibitor program.

License and other revenue

In March 2009, SARcode acquired our interest in
all of its LFA-1 patents and related know-how for a total cash consideration of $2.0 million, which was recorded as revenue in April 2009. In connection with the sale, the license agreement was terminated and we will not receive any future license
fees, milestones or royalties under that license. We still hold three secured convertible promissory notes issued under the original license agreement, with a total principal value of $1.0 million, which are due in 2012 and are convertible into the
preferred stock of SARcode at our option. We have yet to record the amount represented by these notes as revenue, due to uncertainty of their collectibility.

Overview of Operating Expenses

Research and development expense.
Most of our operating expenses to date have been for research and development activities, and include costs incurred:



| |  |  | in the preparation and execution of clinical trials, including those for vosaroxin;
| | - |  | -----------------------------------------------------------------------------------



| |  |  | in the discovery and development of novel small molecule therapeutics;
| | - |  | ----------------------------------------------------------------------



| |  |  | in the development of novel fragment-based drug discovery methods;
| | - |  | ------------------------------------------------------------------



| |  |  | in the development and use of in-house research, preclinical study and development capabilities;
| | - |  | ------------------------------------------------------------------------------------------------



| |  |  | in connection with in-licensing activities; and
| | - |  | -----------------------------------------------



| |  |  | in the conduct of activities related to strategic collaborations.
| | - |  | -----------------------------------------------------------------

We expense all research and development costs as they are incurred.

We do not anticipate incurring any significant additional research expenses related to the discovery of additional product candidates,
the development or application of our proprietary fragment-based drug discovery methods, or the development of in-house research capabilities. In addition, we are no longer conducting any research activities in connection with our
collaborations.

In December 2010, we commenced enrollment of the VALOR trial. Payments to sites for start-up costs and
patient treatment are expected to increase in 2011 as sites are activated to enroll patients. Similarly, costs incurred by our contract research organization and other third party contractors, including the contract manufacturers of the vosaroxin
API and FDP, in the execution of the trial are expected to increase in 2011. As a result, we expect research and development expense to be significantly higher in 2011 as compared to 2010.

We are currently developing vosaroxin in AML. Based on results of translational research, clinical results, regulatory and
competitive concerns and our overall financial resources, we anticipate that we will make determinations as to which indications to pursue and patient populations to treat in the future, and how much funding to direct to each indication on an
ongoing basis. This will affect our research and development expense going forward.



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If we engage a development or commercialization partner for our vosaroxin program, or if, in
the future, we acquire additional product candidates, our research and development expenses could be significantly affected. We cannot predict whether future licensing or collaborative arrangements will be secured, if at all, and to what degree
such arrangements would affect our development plans and capital requirements.

As of December 31, 2010, we had incurred
$78.1 million of expenses in the development of vosaroxin since it was licensed from Dainippon Sumitomo Pharma Co., Ltd., or Dainippon, in October 2003. We expect to continue to incur significant expenses related to the development of vosaroxin in
2011 and future years. Due to the above uncertainties and other risks inherent in the development process, we are unable to estimate the significant costs we will incur in the vosaroxin development program.

Under our collaboration agreement with Biogen Idec, we have the right to participate in the co-development and co-promotion of product
candidates for up to two targets including, at our option, the Raf kinase target, on a worldwide basis (excluding Japan). If we were to exercise our option on one or more product candidates, our research and development expense would increase
significantly. In November 2010, Biogen Idec announced that it will seek to spin out or outlicense certain oncology assets, including this collaboration agreement. We cannot predict the outcome of this strategic decision by Biogen Idec or its
impact on future development activity under the collaboration agreement. We expect that a Phase 1 clinical trial will be initiated in 2011 for the Raf kinase inhibitor program.

General and administrative expense. Our general and administrative expense consists primarily of salaries and other related costs
for personnel in finance, legal, marketing, information technology, administration and general management, as well as non-cash stock-based compensation. Other significant costs include fees paid to professional services providers and those related
to facilities. In 2011, we expect general and administrative expense to be generally comparable to 2010.

Results of Operations

Years Ended December 31, 2010 and 2009

Revenue. Total revenue decreased to $33,000 in 2010 from $3.8 million in 2009. Collaboration revenue of $1.6 million in 2009
was primarily comprised of a $1.5 million milestone earned from Biogen Idecs selection of a Raf kinase inhibitor development candidate for the treatment of cancer. License and other revenue of $2.2 million in 2009 was primarily comprised of
$2.0 million from the sale to SARcode Corporation of our interest in all patents and related know-how that had previously been the subject of a license agreement with them.

Research and development expense. Research and development expense increased to $14.4 million in 2010 from $13.2 million in 2009, with substantially all of the expense in each period relating to
the vosaroxin development program. The increase in 2010 was primarily due to an increase in clinical expenses, primarily related to the launch of the VALOR trial, of $1.0 million and the accrual of a $0.5 million milestone payment due to Dainippon
as a result of the initiation of the VALOR trial in December 2010, which we partially offset by a reduction in facility costs of $0.3 million.

General and administrative expense. General and administrative expense decreased to $7.0 million in 2010 from $7.7 million in 2009. The decrease in 2010 was primarily due to a
restructuring plan initiated in March 2009, or the 2009 Restructuring, which resulted in a reduction of $0.8 million in headcount-related expenses, including $0.5 million related to non-cash stock compensation expense.

Restructuring charges. There were no restructuring charges in 2010. Restructuring charges were $1.9 million in 2009, which
included $1.3 million for lease termination activities related to a corporate realignment initiated in June 2008, or the 2008 Restructuring, and $0.6 million for employee severance and related benefit costs related to the 2009 Restructuring.



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Other income (expense), net. Other expense, net was $3.2 million in 2010 as compared
to $21.1 million in 2009. The net expense in 2010 was primarily due to a non-cash charge of $3.7 million for the revaluation of warrants issued in the 2010 Offering to their fair value as of December 31, 2010, partially offset by the receipt of
a tax credit of $0.2 million under the IRS Qualifying Therapeutic Discovery Project program. The net expense in 2009 was primarily due to non-cash charges of $21.0 million related to the accounting for the Private Placement, which consisted of $7.5
million recorded upon the initial closing in April 2009 and $13.5 million upon the revaluation in June 2009 of the Second Closing Option and Common Equity Closing Option.

Years Ended December 31, 2009 and 2008

Revenue. Total
revenue decreased to $3.8 million in 2009 from $5.4 million in 2008. Collaboration revenue decreased to $1.6 million in 2009 from $4.9 million in 2008, primarily due to the completion of research funding and technology access fee
amortization under the Biogen Idec collaboration in June 2008, partially offset by an increase in milestone revenue in 2009 as a result of a $1.5 million milestone from Biogen Idec, as described above. License and other revenue increased to $2.2
million in 2009 from $0.5 million in 2008, primarily due to the sale to SARcode of certain intellectual property, as described above.

Research and development expense. Research and development expense decreased to $13.2 million in 2009 from $26.3 million in 2008. The decrease was primarily due to the 2008 Restructuring, which
resulted in decreases in headcount-related expenses of $4.2 million, allocated facility costs of $3.3 million, clinical expenses of $2.6 million and professional service costs of $1.8 million.

General and administrative expense. General and administrative expense decreased to $7.7 million in 2009 from
$11.5 million in 2008. The decrease was primarily due to the 2008 Restructuring and the 2009 Restructuring, which together resulted in decreases in headcount-related expenses of $2.1 million, facility costs of $0.9 million and a reduction
in professional service costs of $0.5 million.

Restructuring charges. Restructuring charges were $1.9 million in 2009
as compared to $5.8 million in 2008. The charges for 2009 are described above. The 2008 charges were primarily comprised of $5.9 million related to the 2008 Restructuring, which consisted of $3.6 million for employee severance and related benefit
costs, including non-cash stock-based compensation of $0.4 million, and $2.3 million related to asset impairment and facility exit costs.

Other income (expense), net. Other expense, net was $21.1 million in 2009 as compared to other income, net of $1.0 million in 2008. The net expense in 2009 was primarily due to non-cash charges of
$21.0 million related to the accounting for the Private Placement, as described above. The net income in 2008 primarily related to interest income.

Income Taxes

Deferred tax assets or liabilities may arise from
differences between the tax basis of assets or liabilities and their basis for financial reporting. Deferred tax assets or liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which temporary
differences are expected to be recovered or settled. Valuation allowances are established when necessary to reduce deferred tax assets to the amounts expected to be realized. Our policy is to recognize interest charges and penalties as other
expense.

Since inception, we have incurred operating losses and, accordingly, have not recorded a provision for income taxes
for any of the periods presented. As of December 31, 2010, we had net operating loss carry-forwards for federal and state income tax purposes of $253.6 million and $155.6 million, respectively. We also had federal and state research
and development tax credit carry-forwards of $5.8 million and $5.6 million, respectively. If not utilized, the federal net operating loss and tax credit carry-forwards will expire at various dates beginning in 2018 and the state net
operating loss will begin to expire in 2012. The state research and



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development tax credit carry-forwards do not expire. Utilization of these net operating loss and tax credits carry-forwards may be subject to a substantial annual limitation due to ownership
change rules under Section 382 of the Internal Revenue Code of 1986, as amended, or the Code. The limitations are applicable if an ownership change, as defined in the Code, is deemed to have occurred or occurs in the future. The
annual limitation may result in the expiration of net operating loss and credit carry-forwards before they can be utilized.

Liquidity and
Capital Resources

Sources of Liquidity

Since our inception, we have funded our operations primarily through the issuance of common and preferred stock, the receipt of funds
from our collaboration partners, and from debt financings.

Our cash, cash equivalents and marketable securities totaled
$53.4 million as of December 31, 2010, compared to $4.3 million as of December 31, 2009. The increase of $49.1 million was primarily due to net proceeds of $27.5 million from sales of our common stock through Cantor, $26.7
million from the third closing of the Private Placement, and $14.2 million from the 2010 Offering, partially offset by $19.4 million of net cash used in operating activities.

In January 2010, we entered into our first controlled equity offering sales agreement with Cantor, under which we sold an aggregate of 2.6 million shares of common stock at an average price of $5.67
per share for gross proceeds of $15.0 million. Net proceeds were $14.2 million after deducting Cantors commission and costs to set up the facility.

In April 2010, we entered into a second controlled equity offering sales agreement with Cantor, pursuant to which we may issue and sell shares of our common stock having an aggregate offering price of up
to $20.0 million from time to time through Cantor acting as agent and/or principal, subject to certain conditions. Cantor is entitled to a 3% commission rate of the gross sales price per share of any common stock sold through Cantor as agent under
the sales agreement. As of December 31, 2010, we had sold an aggregate of 3.1 million shares of common stock at an average price of $4.60 per share for gross proceeds of $14.2 million. Net proceeds were $13.7 million after deducting
Cantors commission and costs to set up the facility, of which $0.4 million was received upon settlement in January 2011. As of December 31, 2010, $5.8 million of common stock was available to be sold under this facility, subject to
certain conditions as specified in the agreement.

In June 2010, we completed the third and final closing of the Private
Placement, issuing 17.3 million shares of common stock to the investors at a purchase price of $1.65 per share, for gross proceeds of $28.5 million and net proceeds of $26.7 million.

In October 2010, we completed the 2010 Offering, pursuant to which we issued an aggregate of 7.4 million shares of our common stock
and warrants to purchase 3.7 million shares of our common stock, for aggregate gross proceeds of $15.5 million. Net proceeds from the sale were $14.2 million, after deducting the underwriting discount and offering expenses. The warrants are
exercisable beginning six months after issuance at an exercise price of $2.52 per share, and expire five years from the date of issuance.

Cash Flows

Net cash used in operating activities was $19.4 million
in 2010, compared to $20.2 million used in 2009 and $35.5 million in 2008. Net cash used in 2010 resulted primarily from the net loss of $24.6 million, partially offset by net adjustments for non-cash items of $4.5 million (including $3.7
million of charges related to the 2010 Offering). Net cash used in 2009 resulted primarily from the net loss of $40.2 million, and changes in operating assets and liabilities of $1.3 million, partially offset by net adjustments for non-cash items of
$21.4 million (including $21.0 million of charges related to the Private Placement and $1.3 million of stock-based



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compensation, partially offset by a $1.4 million credit for deferred rent related to the 2008 Restructuring). Net cash used in 2008 resulted primarily from the net loss of $37.2 million, and
changes in operating assets and liabilities of $3.0 million (including decreases of $1.2 million in deferred revenue and $1.7 million in accrued compensation), partially offset by adjustments for non-cash items of $4.8 million (including $1.9
million of restructuring charges, $1.9 million of stock-based compensation and $1.1 million of depreciation and amortization).

Net cash used in investing activities was $39.1 million in 2010, compared to $4.7 million and $32.3 million provided by investing
activities in 2009 and 2008, respectively. Net cash used in 2010 consisted primarily of net outflows from marketable securities transactions. Net cash provided in 2009 consisted primarily of net proceeds from marketable securities transactions
of $4.3 million. Net cash provided in 2008 consisted primarily of net proceeds from marketable securities transactions of $31.6 million.

Net cash provided by financing activities was $68.4 million in 2010, compared to $13.4 million provided by financing activities in 2009, and $2.2 million used in financing activities in 2008. Net
cash provided in the 2010 period consisted primarily of net proceeds of $26.7 million from the third closing of the Private Placement, $27.5 million from sales of common stock under the two controlled equity offering sales agreements with Cantor,
and $14.2 million from the 2010 Offering. Net cash provided in 2009 consisted primarily of net proceeds from the initial and second closings of the Private Placement. Net cash used in 2008 consisted primarily of equipment loan repayments of $2.3
million.

Operating Cash Requirements

We expect to continue to incur substantial operating losses in the future. We will not receive any product revenue until a product candidate has been approved by the FDA or similar regulatory
agencies in other countries, and has been successfully commercialized, if at all. We need to raise substantial additional funding to complete the development and potential commercialization of vosaroxin. Additionally, we may evaluate in-licensing
and acquisition opportunities to gain access to new drugs or drug targets that would fit with our strategy. Any such transaction would likely increase our funding needs in the future.

Our future funding requirements will depend on many factors, including but not limited to:



| |  |  | the rate of progress and cost of our clinical trials, including the VALOR trial in particular;
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | the need for additional or expanded clinical trials (including in particular potential expansion of the number of patients included in the VALOR trial
based on the pre-specified interim analysis of data from the trial by the DSMB);
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the timing and economic and other terms of any licensing, collaboration or other similar arrangement into which we may enter;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs and timing of seeking and obtaining FDA and other regulatory approvals;
| | - |  | ---------------------------------------------------------------------------------



| |  |  | the extent of our other development activities;
| | - |  | -----------------------------------------------



| |  |  | the costs associated with building or accessing commercialization and additional manufacturing capabilities and supplies;
| | - |  | -------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs of acquiring or investing in businesses, product candidates and technologies, if any;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | the costs of filing, prosecuting, defending and enforcing any patent claims and other intellectual property rights;
| | - |  | -------------------------------------------------------------------------------------------------------------------



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| |  |  | the effect of competing technological and market developments; and
| | - |  | ------------------------------------------------------------------



| |  |  | the costs of supporting our collaboration with Biogen Idec, if any.
| | - |  | -------------------------------------------------------------------

We believe that we currently have the resources available and accessible to fund our operations until the planned unblinding of the VALOR
trial in 2013. To the extent that the costs of the VALOR trial exceed our current estimates, unblinding does not occur within the currently anticipated timeframe or we are unable to raise sufficient additional capital through our controlled equity
offering facility or otherwise, we will need to reduce operating expenses, enter into a collaboration or other similar arrangement with respect to development and/or commercialization rights to vosaroxin, outlicense intellectual property rights to
vosaroxin, sell assets, or a combination of the above.

We will need to raise substantial additional capital if we expand the
number of patients included in the VALOR trial based on the pre-specified interim analysis of data from the trial by the DSMB. In addition, we will need to raise substantial additional capital to complete the development and potential
commercialization of vosaroxin. We expect to finance our future cash needs primarily through equity issuances, debt arrangements, a possible license, collaboration or other similar arrangement with respect to development and/or commercialization
rights to vosaroxin, or a combination of the above.

Until we can generate a sufficient amount of collaboration or product
revenue to finance our cash requirements, which we may never do, we expect to finance future cash needs primarily through the above means. However, we do not know whether additional funding will be available on acceptable terms, or at all.
Our failure to raise significant additional capital in the future would force us to delay or reduce the scope of our vosaroxin development program, potentially including the VALOR trial, and/or limit or cease our operations. Any one of the foregoing
would have a material adverse effect on our business, financial condition and results of operations.

Contractual Obligations

Our operating lease obligations as of December 31, 2010 relate solely to the lease of approximately 15,000 square
feet of office space in a building at 395 Oyster Point Boulevard in South San Francisco, California, which is currently our corporate headquarters. The lease was entered into in December 2006, and expires in April 2013, subject to our option to
extend the lease through February 2014.

Under our license agreement with Dainippon, we are required to make certain milestone
payments in the event we file new drug applications in the United States, Europe or Japan, and if we receive regulatory approvals in any of these regions, for cancer-related indications. If vosaroxin is approved for a non-cancer indication, an
additional milestone payment becomes payable to Dainippon.

We also have agreements with CROs, clinical sites and other third
party contractors for the conduct of our clinical trials. We generally make payments to these entities based upon the activities they perform related to the particular clinical trial. There are generally no penalty clauses for cancellation of these
agreements if notice is duly given and payment is made for work performed by the third party under the related agreement.

Off-Balance
Sheet Arrangements

Since our inception, we have not had any off-balance sheet arrangements or relationships with
unconsolidated entities or financial partnerships, such as entities often referred to as structured finance or variable interest entities, which are typically established for the purpose of facilitating off-balance sheet arrangements or other
contractually narrow or limited purposes.



|ITEM | 7A:QUALITATIVE AND QUANTITATIVE DISCLOSURES ABOUT MARKET RISK
|---- | -------------------------------------------------------------

This item is not applicable to us as a smaller reporting company.



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|ITEM 8: | FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA
|------- | -------------------------------------------

Index to Consolidated Financial Statements



|                                                        |  |      |    | 
|------------------------------------------------------- |  | ---- | -- | 
|                                                        |  | Page |   
|Report of Independent Registered Public Accounting Firm |  |      | 50 | 
|Consolidated Balance Sheets                             |  |      | 51 | 
|Consolidated Statements of Operations                   |  |      | 52 | 
|Consolidated Statements of Stockholders Equity         |  |      | 53 | 
|Consolidated Statements of Cash Flows                   |  |      | 54 | 
|Notes to Consolidated Financial Statements              |  |      | 55 | 



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Report of Independent Registered Public Accounting Firm

The Board of Directors and Stockholders of Sunesis Pharmaceuticals, Inc.

We have audited the accompanying consolidated balance sheets of Sunesis Pharmaceuticals, Inc. as of December 31, 2010 and 2009,
and the related consolidated statements of operations, stockholders equity, and cash flows for each of the three years in the period ended December 31, 2010. These financial statements are the responsibility of Sunesis Pharmaceuticals,
Inc.s management. Our responsibility is to express an opinion on these financial statements based on our audits.

We
conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements
are free of material misstatement. We were not engaged to perform an audit of the Companys internal control over financial reporting. Our audits included consideration of internal control over financial reporting as a basis for designing audit
procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Companys internal control over financial reporting. Accordingly, we express no such opinion. An audit
also includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, and evaluating the overall financial
statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial
statements referred to above present fairly, in all material respects, the consolidated financial position of Sunesis Pharmaceuticals, Inc. at December 31, 2010 and 2009, and the consolidated results of its operations and its cash flows for
each of the three years in the period ended December 31, 2010, in conformity with U.S. generally accepted accounting principles.

/s/
ERNST & YOUNG, LLP

Palo Alto, California

March 29, 2011



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SUNESIS PHARMACEUTICALS, INC.

CONSOLIDATED BALANCE SHEETS



|                                                                                                                                                                                                                                                                           |  |              |              |   |      |   |              |  
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | ------------ | - | ---- | - | ------------ | -
|                                                                                                                                                                                                                                                                           |  | December 31, |             
|                                                                                                                                                                                                                                                                           |  | 2010         |              |   | 2009 |  
|ASSETS                                                                                                                                                                                                                                                                     |  |              |              |   |      |   |              |  
|Current assets:                                                                                                                                                                                                                                                            |  |              |              |   |      |   |              |  
|Cash and cash equivalents                                                                                                                                                                                                                                                  |  | $            | 14,223,388   |   |      | $ | 4,258,715    |  
|Marketable securities                                                                                                                                                                                                                                                      |  |              | 39,172,480   |   |      |   |             |  
|Prepaids and other current assets                                                                                                                                                                                                                                          |  |              | 1,285,487    |   |      |   | 583,030      |  
|                                                                                                                                                                                                                                                                           |  |              |              |   |      |   |              |  
|Total current assets                                                                                                                                                                                                                                                       |  |              | 54,681,355   |   |      |   | 4,841,745    |  
|Property and equipment, net                                                                                                                                                                                                                                                |  |              | 116,188      |   |      |   | 263,111      |  
|Deposits and other assets                                                                                                                                                                                                                                                  |  |              | 59,974       |   |      |   | 64,425       |  
|                                                                                                                                                                                                                                                                           |  |              |              |   |      |   |              |  
|Total assets                                                                                                                                                                                                                                                               |  | $            | 54,857,517   |   |      | $ | 5,169,281    |  
|                                                                                                                                                                                                                                                                           |  |              |              |   |      |   |              |  
|LIABILITIES AND STOCKHOLDERS EQUITY                                                                                                                                                                                                                                       |  |              |              |   |      |   |              |  
|Current liabilities:                                                                                                                                                                                                                                                       |  |              |              |   |      |   |              |  
|Accounts payable                                                                                                                                                                                                                                                           |  | $            | 415,802      |   |      | $ | 360,300      |  
|Accrued clinical expense                                                                                                                                                                                                                                                   |  |              | 1,573,580    |   |      |   | 1,129,226    |  
|Accrued compensation                                                                                                                                                                                                                                                       |  |              | 1,013,240    |   |      |   | 728,744      |  
|Other accrued liabilities                                                                                                                                                                                                                                                  |  |              | 1,380,409    |   |      |   | 788,559      |  
|Current portion of deferred rent                                                                                                                                                                                                                                           |  |              | 26,267       |   |      |   | 27,943       |  
|Warrant liability                                                                                                                                                                                                                                                          |  |              | 8,153,712    |   |      |   |             |  
|                                                                                                                                                                                                                                                                           |  |              |              |   |      |   |              |  
|Total current liabilities                                                                                                                                                                                                                                                  |  |              | 12,563,010   |   |      |   | 3,034,772    |  
|                                                                                                                                                                                                                                                                           |  |             
|Non-current portion of deferred rent                                                                                                                                                                                                                                       |  |              | 47,838       |   |      |   | 74,105       |  
|                                                                                                                                                                                                                                                                           |  |             
|Commitments                                                                                                                                                                                                                                                                |  |              |              |   |      |   |              |  
|                                                                                                                                                                                                                                                                           |  |             
|Stockholders equity:                                                                                                                                                                                                                                                      |  |              |              |   |      |   |              |  
|Convertible preferred stock, $0.0001 par value; 10,000,000 shares authorized as of December 31, 2010 and 2009; zero and
724,618 shares outstanding as of December 31, 2010 and 2009, respectively; aggregate liquidation preference of $44,999,854 as of December 31, 2009 |  |              |             |   |      |   | 60,004,986   |  
|Common stock, $0.0001 par value; 400,000,000 and 100,000,000 shares authorized as of December 31, 2010 and 2009,
respectively; 45,371,654 and 5,983,725 shares issued and outstanding as of December 31, 2010 and 2009, respectively                                       |  |              | 4,537        |   |      |   | 3,590        |  
|Additional paid-in capital                                                                                                                                                                                                                                                 |  |              | 423,262,099  |   |      |   | 298,469,584  |  
|Accumulated other comprehensive loss                                                                                                                                                                                                                                       |  |              | (14,726      | ) |      |   |             |  
|Accumulated deficit                                                                                                                                                                                                                                                        |  |              | (381,005,241 | ) |      |   | (356,417,756 | )
|                                                                                                                                                                                                                                                                           |  |              |              |   |      |   |              |  
|Total stockholders equity                                                                                                                                                                                                                                                 |  |              | 42,246,669   |   |      |   | 2,060,404    |  
|                                                                                                                                                                                                                                                                           |  |              |              |   |      |   |              |  
|Total liabilities and stockholders equity                                                                                                                                                                                                                                 |  | $            | 54,857,517   |   |      | $ | 5,169,281    |  
|                                                                                                                                                                                                                                                                           |  |              |              |   |      |   |              |  

See accompanying notes to consolidated financial statements.



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SUNESIS PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS



|                                                                                                     |  |                         |             |   |      |   |             |      |  |   |             |  
|---------------------------------------------------------------------------------------------------- |  | ----------------------- | ----------- | - | ---- | - | ----------- | ---- |  | - | ----------- | -
|                                                                                                     |  | Year Ended December 31, |            
|                                                                                                     |  | 2010                    |             |   | 2009 |   |             | 2008 | 
|Revenue:                                                                                             |  |                         |             |   |      |   |             |      |  |   |             |  
|Collaboration revenue                                                                                |  | $                       | 27,083      |   |      | $ | 1,550,000   |      |  | $ | 4,917,340   |  
|License and other revenue                                                                            |  |                         | 6,000       |   |      |   | 2,211,547   |      |  |   | 500,000     |  
|                                                                                                     |  |                         |             |   |      |   |             |      |  |   |             |  
|Total revenues                                                                                       |  |                         | 33,083      |   |      |   | 3,761,547   |      |  |   | 5,417,340   |  
|Operating expenses:                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Research and development                                                                             |  |                         | 14,433,777  |   |      |   | 13,246,859  |      |  |   | 26,285,294  |  
|General and administrative                                                                           |  |                         | 7,004,909   |   |      |   | 7,748,243   |      |  |   | 11,524,198  |  
|Restructuring charges                                                                                |  |                         |            |   |      |   | 1,915,316   |      |  |   | 5,782,903   |  
|                                                                                                     |  |                         |             |   |      |   |             |      |  |   |             |  
|Total operating expenses                                                                             |  |                         | 21,438,686  |   |      |   | 22,910,418  |      |  |   | 43,592,395  |  
|                                                                                                     |  |                         |             |   |      |   |             |      |  |   |             |  
|Loss from operations                                                                                 |  |                         | (21,405,603 | ) |      |   | (19,148,871 | )    |  |   | (38,175,055 | )
|Other income (expense), net                                                                          |  |                         | (3,181,882  | ) |      |   | (21,077,175 | )    |  |   | 989,428     |  
|                                                                                                     |  |                         |             |   |      |   |             |      |  |   |             |  
|Net loss                                                                                             |  |                         | (24,587,485 | ) |      |   | (40,226,046 | )    |  |   | (37,185,627 | )
|Deemed distribution to preferred stockholders                                                        |  |                         |            |   |      |   | (27,563,400 | )    |  |   |            |  
|                                                                                                     |  |                         |             |   |      |   |             |      |  |   |             |  
|Loss attributable to common stockholders                                                             |  | $                       | (24,587,485 | ) |      | $ | (67,789,446 | )    |  | $ | (37,185,627 | )
|                                                                                                     |  |                         |             |   |      |   |             |      |  |   |             |  
|Basic and diluted loss attributable to common stockholders per common share                          |  | $                       | (0.99       | ) |      | $ | (11.80      | )    |  | $ | (6.49       | )
|                                                                                                     |  |                         |             |   |      |   |             |      |  |   |             |  
|Shares used in computing basic and diluted loss attributable to common stockholders per common share |  |                         | 24,860,212  |   |      |   | 5,746,786   |      |  |   | 5,731,196   |  
|                                                                                                     |  |                         |             |   |      |   |             |      |  |   |             |  

See accompanying notes to consolidated financial statements.



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SUNESIS PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENTS OF STOCKHOLDERS EQUITY



|                                                                                                                                                                                  |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   |             |  
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | -------------------------- | -------- | - | ------------ | - | ----------- | ------------------------ |  |  | -------------------------- |  |  | ------------------------------------------- | ------- | - | ------------------- | - | ----------- | ------------------------- |  | - | -------- | - |  | - | ------- | - |  | - | ------------ | - |  | - | ----------- | -
|                                                                                                                                                                                  |  | Convertible PreferredStock |          |   | Common Stock |   |             | AdditionalPaid-InCapital |  |  | DeferredStockCompen-sation |  |  | Accum-ulatedOtherCompre-hensiveIncome(Loss) |         |   | Accum-ulatedDeficit |   |             | TotalStock-holdersEquity | 
|                                                                                                                                                                                  |  | Shares                     |          |   | Amount       |   |             | Shares                   |  |  | Amount                     |  |  |                                             |         |   |                    
|Balance as of December 31, 2007                                                                                                                                                   |  |                            |         |   |              | $ |            |                          |  |  | 5,727,442                  |  |  | $                                           | 3,437   |   |                     |   | 320,579,240 |                           |  | $ | (251,601 | ) |  | $ | 69,262  |   |  | $ | (279,006,083 | ) |  | $ | 41,394,255  |  
|Issuance of common stock under employee stock purchase plan                                                                                                                       |  |                            |         |   |              |   |            |                          |  |  | 7,467                      |  |  |                                             | 4       |   |                     |   | 66,572      |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 66,576      |  
|Issuance of common stock to employees                                                                                                                                             |  |                            |         |   |              |   |            |                          |  |  | 11                         |  |  |                                             |        |   |                     |   |            |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   |            |  
|Stock-based compensation expenseemployees                                                                                                                                        |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   | 1,686,827   |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 1,686,827   |  
|Stock-based compensation expensenon-employees                                                                                                                                    |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   | 828         |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 828         |  
|Stock-based compensation expenserestructuring                                                                                                                                    |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   | 366,637     |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 366,637     |  
|Reversal of deferred stock-based compensation                                                                                                                                     |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   | (28,500     | )                         |  |   | 28,500   |   |  |   |        |   |  |   |             |   |  |   |            |  
|Amortization deferred stock-based compensation                                                                                                                                    |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   |            |                           |  |   | 223,101  |   |  |   |        |   |  |   |             |   |  |   | 223,101     |  
|Components of comprehensive loss:                                                                                                                                                 |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   |             |  
|Net loss                                                                                                                                                                          |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   |            |                           |  |   |         |   |  |   |        |   |  |   | (37,185,627  | ) |  |   | (37,185,627 | )
|Unrealized loss on available-for-sale securities                                                                                                                                  |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   |            |                           |  |   |         |   |  |   | (61,421 | ) |  |   |             |   |  |   | (61,421     | )
|                                                                                                                                                                                  |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   |             |  
|Comprehensive loss                                                                                                                                                                |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   | (37,247,048 | )
|                                                                                                                                                                                  |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   |             |  
|Balance as of December 31, 2008                                                                                                                                                   |  |                            |         |   |              |   |            |                          |  |  | 5,734,920                  |  |  |                                             | 3,441   |   |                     |   | 322,671,604 |                           |  |   |         |   |  |   | 7,841   |   |  |   | (316,191,710 | ) |  |   | 6,491,176   |  
|Issuance of $10,000,000 of units consisting of preferred stock and warrants in initial closing of Private Placement, recorded in
liabilities                                      |  |                            | 483,081  |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   |            |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   |            |  
|Reclassification of preferred stock from liabilities to equity                                                                                                                    |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   | 20,126,000  |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 20,126,000  |  
|Reclassification of second closing option of Private Placement from liabilities to equity and issuance of amended preferred stock
instrument, net of issuance costs of $1,245,757 |  |                            |         |   |              |   | 56,146,243  |                          |  |  |                           |  |  |                                             |        |   |                     |   | (46,501,000 | )                         |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 9,645,243   |  
|Issuance of $5,000,000 of units consisting of preferred stock and warrants in second closing of Private Placement, net of
issuance costs of $321,185                              |  |                            | 241,537  |   |              |   | 2,670,343   |                          |  |  |                           |  |  |                                             |        |   |                     |   | 2,008,472   |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 4,678,815   |  
|Write-off of discount for beneficial conversion feature on second closing of Private Placement                                                                                    |  |                            |         |   |              |   | 1,188,400   |                          |  |  |                           |  |  |                                             |        |   |                     |   | (1,188,400  | )                         |  |   |         |   |  |   |        |   |  |   |             |   |  |   |            |  
|Issuance of common stock pursuant to warrant exercises                                                                                                                            |  |                            |         |   |              |   |            |                          |  |  | 244,908                    |  |  |                                             | 147     |   |                     |   | (147        | )                         |  |   |         |   |  |   |        |   |  |   |             |   |  |   |            |  
|Issuance of common stock pursuant to stock option exercises                                                                                                                       |  |                            |         |   |              |   |            |                          |  |  | 759                        |  |  |                                             |        |   |                     |   | 6,562       |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 6,562       |  
|Issuance of common stock under employee stock purchase plan                                                                                                                       |  |                            |         |   |              |   |            |                          |  |  | 3,136                      |  |  |                                             | 2       |   |                     |   | 6,140       |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 6,142       |  
|Issuance of common stock to employees                                                                                                                                             |  |                            |         |   |              |   |            |                          |  |  | 2                          |  |  |                                             |        |   |                     |   |            |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   |            |  
|Stock-based compensation expensesemployees                                                                                                                                       |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   | 1,310,945   |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 1,310,945   |  
|Stock-based compensation expensesnon-employees                                                                                                                                   |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   | 29,408      |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 29,408      |  
|Components of comprehensive loss:                                                                                                                                                 |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   |             |  
|Net loss                                                                                                                                                                          |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   |            |                           |  |   |         |   |  |   |        |   |  |   | (40,226,046  | ) |  |   | (40,226,046 | )
|Unrealized loss on available-for-sale securities                                                                                                                                  |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   |            |                           |  |   |         |   |  |   | (7,841  | ) |  |   |             |   |  |   | (7,841      | )
|                                                                                                                                                                                  |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   |             |  
|Comprehensive loss                                                                                                                                                                |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   | (40,233,887 | )
|                                                                                                                                                                                  |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   |             |  
|Balance as of December 31, 2009                                                                                                                                                   |  |                            | 724,618  |   |              |   | 60,004,986  |                          |  |  | 5,983,725                  |  |  |                                             | 3,590   |   |                     |   | 298,469,584 |                           |  |   |         |   |  |   |        |   |  |   | (356,417,756 | ) |  |   | 2,060,404   |  
|Issuance of $28,500,000 of common stock in third closing of Private Placement, net of issuance costs of
$1,786,786                                                                |  |                            |         |   |              |   |            |                          |  |  | 17,272,716                 |  |  |                                             | 10,364  |   |                     |   | 26,702,850  |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 26,713,214  |  
|Issuance of common stock upon conversion of preferred stock                                                                                                                       |  |                            | (724,618 | ) |              |   | (60,004,986 | )                        |  |  | 7,246,339                  |  |  |                                             | 4,348   |   |                     |   | 60,000,638  |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   |            |  
|Issuance of $28,819,974 of common stock through controlled equity offering facilities, net of issuance costs of
$1,332,292                                                        |  |                            |         |   |              |   |            |                          |  |  | 5,725,908                  |  |  |                                             | 3,364   |   |                     |   | 27,484,318  |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 27,487,682  |  
|Issuance of $10,961,379 of common stock in 2010 Offering, net of issuance costs of $1,233,056                                                                                     |  |                            |         |   |              |   |            |                          |  |  | 7,357,610                  |  |  |                                             | 4,415   |   |                     |   | 9,723,908   |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 9,728,323   |  
|Issuance of common stock pursuant to warrant exercises                                                                                                                            |  |                            |         |   |              |   |            |                          |  |  | 1,764,322                  |  |  |                                             | 1,059   |   |                     |   | (1,059      | )                         |  |   |         |   |  |   |        |   |  |   |             |   |  |   |            |  
|Issuance of common stock pursuant to stock option exercises                                                                                                                       |  |                            |         |   |              |   |            |                          |  |  | 1,250                      |  |  |                                             | 1       |   |                     |   | 3,674       |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 3,675       |  
|Issuance of common stock under employee stock purchase plan                                                                                                                       |  |                            |         |   |              |   |            |                          |  |  | 3,528                      |  |  |                                             | 2       |   |                     |   | 5,756       |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 5,758       |  
|Issuance of common stock to employees                                                                                                                                             |  |                            |         |   |              |   |            |                          |  |  | 16,256                     |  |  |                                             | 10      |   |                     |   | (27,410     | )                         |  |   |         |   |  |   |        |   |  |   |             |   |  |   | (27,400     | )
|Stock-based compensation expensesemployees                                                                                                                                       |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   | 870,366     |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 870,366     |  
|Stock-based compensation expensesnon-employees                                                                                                                                   |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   | 6,858       |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   | 6,858       |  
|Adjustment of common stock to par value as a result of Reverse Split                                                                                                              |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             | (22,616 | ) |                     |   | 22,616      |                           |  |   |         |   |  |   |        |   |  |   |             |   |  |   |            |  
|Components of comprehensive loss:                                                                                                                                                 |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   |             |  
|Net loss                                                                                                                                                                          |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   |            |                           |  |   |         |   |  |   |        |   |  |   | (24,587,485  | ) |  |   | (24,587,485 | )
|Unrealized loss on available-for-sale securities                                                                                                                                  |  |                            |         |   |              |   |            |                          |  |  |                           |  |  |                                             |        |   |                     |   |            |                           |  |   |         |   |  |   | (14,726 | ) |  |   |             |   |  |   | (14,726     | )
|                                                                                                                                                                                  |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   |             |  
|Comprehensive loss                                                                                                                                                                |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   | (24,602,211 | )
|                                                                                                                                                                                  |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   |             |  
|Balance as of December 31, 2010                                                                                                                                                   |  |                            |         |   |              | $ |            |                          |  |  | 45,371,654                 |  |  | $                                           | 4,537   |   |                     | $ | 423,262,099 |                           |  | $ |         |   |  | $ | (14,726 | ) |  | $ | (381,005,241 | ) |  | $ | 42,246,669  |  
|                                                                                                                                                                                  |  |                            |          |   |              |   |             |                          |  |  |                            |  |  |                                             |         |   |                     |   |             |                           |  |   |          |   |  |   |         |   |  |   |              |   |  |   |             |  

See accompanying notes to consolidated financial statements.



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SUNESIS PHARMACEUTICALS, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS



|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|----------------------------------------------------------------------------------------------------------------- |  | ----------------------- | ----------- | - | ---- | - | ----------- | ---- |  | - | ----------- | -
|                                                                                                                  |  | Year Ended December 31, |            
|                                                                                                                  |  | 2010                    |             |   | 2009 |   |             | 2008 | 
|Cash flows from operating activities                                                                              |  |                         |             |   |      |   |             |      |  |   |             |  
|Net loss                                                                                                          |  | $                       | (24,587,485 | ) |      | $ | (40,226,046 | )    |  | $ | (37,185,627 | )
|Adjustments to reconcile loss to net cash used in operating activities:                                           |  |                         |             |   |      |   |             |      |  |   |             |  
|Stock-based compensation expense                                                                                  |  |                         | 877,224     |   |      |   | 1,340,353   |      |  |   | 1,910,755   |  
|Depreciation and amortization                                                                                     |  |                         | 150,227     |   |      |   | 341,576     |      |  |   | 1,103,848   |  
|Non-cash expense related to Private Placement                                                                     |  |                         |            |   |      |   | 21,016,997  |      |  |   |            |  
|Non-cash expense for revaluation of warrant liability                                                             |  |                         | 3,664,094   |   |      |   |            |      |  |   |            |  
|Non-cash restructuring (reversals) charges, net                                                                   |  |                         |            |   |      |   | (1,372,634  | )    |  |   | 1,937,821   |  
|(Gain) loss on sale or disposal of property and equipment                                                         |  |                         | (82,239     | ) |      |   | 56,188      |      |  |   | (189,111    | )
|Exchange gain on marketable securities                                                                            |  |                         | (62,966     | ) |      |   |            |      |  |   |            |  
|Other non-cash items                                                                                              |  |                         | (27,400     | ) |      |   |            |      |  |   |            |  
|Changes in operating assets and liabilities:                                                                      |  |                         |             |   |      |   |             |      |  |   |             |  
|Prepaids and other current assets                                                                                 |  |                         | (702,457    | ) |      |   | 351,399     |      |  |   | 11,154      |  
|Deposits and other assets                                                                                         |  |                         | 43,322      |   |      |   | 83,401      |      |  |   | 229,972     |  
|Accounts payable                                                                                                  |  |                         | 55,502      |   |      |   | (430,246    | )    |  |   | (672,171    | )
|Accrued clinical expense                                                                                          |  |                         | 444,354     |   |      |   | (736,547    | )    |  |   | 840,448     |  
|Accrued compensation                                                                                              |  |                         | 284,496     |   |      |   | 191,529     |      |  |   | (1,688,653  | )
|Other accrued liabilities                                                                                         |  |                         | 591,850     |   |      |   | (790,128    | )    |  |   | (503,145    | )
|Deferred rent                                                                                                     |  |                         | (27,943     | ) |      |   | (8,871      | )    |  |   | (56,302     | )
|Deferred revenue                                                                                                  |  |                         |            |   |      |   |            |      |  |   | (1,199,948  | )
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Net cash used in operating activities                                                                             |  |                         | (19,379,421 | ) |      |   | (20,183,029 | )    |  |   | (35,460,959 | )
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Cash flows from investing activities                                                                              |  |                         |             |   |      |   |             |      |  |   |             |  
|Purchases of property and equipment, net                                                                          |  |                         | (64,191     | ) |      |   | (6,140      | )    |  |   | (179,148    | )
|Proceeds from sale of property and equipment                                                                      |  |                         | 104,255     |   |      |   | 391,174     |      |  |   | 876,303     |  
|Purchases of marketable securities                                                                                |  |                         | (46,636,773 | ) |      |   | (503,107    | )    |  |   | (25,902,749 | )
|Proceeds from maturities of marketable securities                                                                 |  |                         | 7,512,533   |   |      |   | 4,817,110   |      |  |   | 57,477,417  |  
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Net cash (used in) provided by investing activities                                                               |  |                         | (39,084,176 | ) |      |   | 4,699,037   |      |  |   | 32,271,823  |  
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Cash flows from financing activities                                                                              |  |                         |             |   |      |   |             |      |  |   |             |  
|Proceeds from issuance of convertible preferred stock and warrants under Private Placement, net of issuance costs |  |                         |            |   |      |   | 13,433,061  |      |  |   |            |  
|Proceeds from issuance of common stock under Private Placement, net of issuance costs                             |  |                         | 26,713,214  |   |      |   |            |      |  |   |            |  
|Proceeds from issuance of common stock through controlled equity offering facilities, net of issuance costs       |  |                         | 27,487,682  |   |      |   |            |      |  |   |            |  
|Proceeds from issuance of common stock and warrants under 2010 Offering, net of issuance costs                    |  |                         | 14,217,941  |   |      |   |            |      |  |   |            |  
|Proceeds from exercise of stock options and from employee stock purchase plan                                     |  |                         | 9,433       |   |      |   | 12,704      |      |  |   | 66,576      |  
|Payments on borrowing under equipment financing                                                                   |  |                         |            |   |      |   |            |      |  |   | (2,306,624  | )
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Net cash provided by (used in) financing activities                                                               |  |                         | 68,428,270  |   |      |   | 13,445,765  |      |  |   | (2,240,048  | )
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Net increase (decrease) in cash and cash equivalents                                                              |  |                         | 9,964,673   |   |      |   | (2,038,227  | )    |  |   | (5,429,184  | )
|Cash and cash equivalents at beginning of period                                                                  |  |                         | 4,258,715   |   |      |   | 6,296,942   |      |  |   | 11,726,126  |  
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Cash and cash equivalents at end of period                                                                        |  | $                       | 14,223,388  |   |      | $ | 4,258,715   |      |  | $ | 6,296,942   |  
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Supplemental disclosure of cash flow information                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Interest paid                                                                                                     |  | $                       | 271         |   |      | $ | 1,187       |      |  | $ | 187,946     |  
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Supplemental disclosure of non-cash activities                                                                    |  |                         |             |   |      |   |             |      |  |   |             |  
|Deemed distributions to preferred stockholders                                                                    |  | $                       |            |   |      | $ | 27,563,400  |      |  | $ |            |  
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Beneficial conversion feature on preferred stock                                                                  |  | $                       |            |   |      | $ | 1,188,400   |      |  | $ |            |  
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Cashless exercise of warrants                                                                                     |  | $                       | 3,063,793   |   |      | $ | 439,780     |      |  | $ |            |  
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Conversion of preferred stock to common stock                                                                     |  | $                       | 60,004,986  |   |      | $ |            |      |  | $ |            |  
|                                                                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  

See accompanying notes to consolidated financial statements.



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SUNESIS PHARMACEUTICALS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

1. Organization and Summary of Significant Accounting Policies

Overview

Sunesis Pharmaceuticals, Inc. (the Company or Sunesis) was incorporated in the state of Delaware on February 10, 1998, and its facilities are located in South San
Francisco, California. Sunesis is a biopharmaceutical company focused on the development and commercialization of new oncology therapeutics for the treatment of solid and hematologic cancers. The Companys primary activities since incorporation
have been conducting research and development internally and through corporate collaborators, in-licensing and out-licensing pharmaceutical compounds and technology, conducting clinical trials and raising capital.

In December 2010, the Company commenced enrollment of a Phase 3, multi-national, randomized, double-blind, placebo-controlled, pivotal
clinical trial of vosaroxin in combination with cytarabine in patients with relapsed or refractory acute myeloid leukemia (the VALOR trial).

Significant Risks and Uncertainties

The Company has incurred
significant losses and negative cash flows from operations since its inception, and as of December 31, 2010, had cash, cash equivalents and marketable securities totaling $53.4 million and an accumulated deficit of $381.0 million.

Sunesis believes that it currently has the resources available and accessible to fund its operations until the planned
unblinding of the VALOR trial in 2013. To the extent that the costs of the VALOR trial exceed the Companys current estimates or the Company is unable to raise sufficient additional capital through its controlled equity offering facility with
Cantor (see Note 9) or otherwise, the Company will need to reduce operating expenses, enter into a collaboration or other similar arrangement with respect to development and/or commercialization rights to vosaroxin, outlicense intellectual property
rights to vosaroxin, sell assets, or a combination of the above.

The Company will need to raise substantial additional
capital if it expands the number of patients included in the trial based on the pre-specified interim analysis of data from the trial by the DSMB. In addition, the Company will need to raise substantial additional capital to complete the development
and potential commercialization of vosaroxin. The Company expects to finance its future cash needs primarily through equity issuances, debt arrangements, a possible license, collaboration or other similar arrangement with respect to development
and/or commercialization rights to vosaroxin, or a combination of the above.

As part of the VALOR trial, payables are
incurred for services that are originally denominated in foreign currencies. According to its investment policy, the Company may purchase certain European currencies or highly-rated investments denominated in those currencies to
manage the risk of future movements in foreign exchange rates that would affect such payables. There is no guarantee that the related gains and losses will substantially offset each other, and the Company may be subject to significant
exchange gains or losses as currencies fluctuate from quarter to quarter.

Basis of Presentation

The accompanying consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles
(GAAP). The financial statements include a wholly owned subsidiary, Sunesis Europe Limited, a United Kingdom corporation. Management has determined that the Company operates as a single reportable segment. The financial statements
include all adjustments (consisting



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only of normal recurring adjustments) that management believes are necessary for a fair presentation of the periods presented. Prior period revenues and interest income (expense) in the
statements of operations and certain liabilities in the balance sheets and statements of cash flows have been reclassified to conform to the current year presentation.

Reverse Stock Split

On February 14, 2011, the Company
effected a one-for-six reverse split of its capital stock (the Reverse Split), as previously authorized and approved at the annual meeting of stockholders on June 2, 2010. As a result of the Reverse Split, every six shares of
capital stock were combined into one share of capital stock. The Reverse Split affected all of the Companys common stock outstanding immediately prior to the effective time of the Reverse Split as well as the number of shares of common stock
available for issuance under the Companys equity incentive plans. In addition, the Reverse Split effected a reduction in the number of shares of common stock issuable upon the exercise of outstanding stock options and warrants. The
accompanying financial statements and notes to the financial statements give retroactive effect to the Reverse Split for all periods presented.

Significant Estimates and Judgments

The preparation of financial
statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the Companys consolidated financial statements and accompanying notes. Actual results could differ materially from
these estimates. Significant estimates, assumptions and judgments made by management include those related to revenue recognition, clinical trial accounting, stock-based compensation and the valuation of equity and related instruments.

Cash Equivalents and Marketable Securities

The Company considers all highly liquid securities with original maturities of three months or less from the date of purchase to be cash equivalents, which generally consist of money market funds and
corporate debt securities. Marketable securities consist of securities with original maturities of greater than three months, which may include U.S. and European government obligations and corporate debt securities.

Management determines the appropriate classification of securities at the time of purchase. The Company generally classifies its entire
investment portfolio as available-for-sale. The Company views its available-for-sale portfolio as available for use in current operations. Accordingly, the Company classifies all investments as short-term, even though the stated maturity may be more
than one year from the current balance sheet date. Available-for-sale securities are carried at fair value, with unrealized gains and losses reported in accumulated other comprehensive income (loss), which is a separate component of
stockholders equity. Estimated fair values are determined by the Company using available market information.

The
amortized cost of securities is adjusted for amortization of premiums and accretion of discounts to maturity. Such amortization and accretion is included in other income (expense) in the statement of operations. Realized gains and losses and
declines in value judged to be other-than-temporary on available-for-sale securities, if any, are also recorded to other income (expense). The cost of securities sold is based on the specific-identification method.

Concentrations of Credit Risk and Financial Instruments

The Company invests cash that is not currently being used for operational purposes in accordance with its investment policy. The policy
allows for the purchase of low risk debt securities issued by the U.S. and certain European governments and government agencies and very highly rated banks and corporations domiciled in the U.S. and certain European countries, subject to certain
concentration limits. The policy limits maturities of



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securities purchased to no longer than 18 months and the dollar-weighted average maturity of the portfolio to nine months. Management believes these guidelines ensure both the safety and
liquidity of any investment portfolio the Company may hold.

Financial instruments that potentially subject the Company to
concentrations of credit risk generally consist of cash, cash equivalents and marketable securities. The carrying amounts of cash equivalents and marketable securities generally approximate fair value due to their short-term nature. The Company
is exposed to credit risk in the event of default by the institutions holding its cash, cash equivalents and any marketable securities to the extent of the amounts recorded in the balance sheets.

Property and Equipment

Property and equipment are stated at cost, less accumulated depreciation and amortization. Depreciation is determined using the straight-line method over the estimated useful lives of the respective
assets, generally three to five years. Leasehold improvements are amortized on a straight-line basis over the shorter of their estimated useful lives or the term of the lease.

Accounting for Equity Financings

The accounting for the initial
and second closing of the sale of $10.0 million and $5.0 million of units, respectively, in the Private Placement (see Note 9), and subsequent revaluations of the related financial instruments, required fair values to be established at different
dates, either individually or in aggregate, for the four primary components of the Private Placement: (a) the Series A convertible preferred stock, (b) the warrants to purchase common stock, (c) the option for the investors to
participate in the second closing (the Second Closing Option), and (d) the option for the investors to participate in the common equity closing (the Common Equity Closing Option). The Option-Pricing Method, which
utilizes the Black-Scholes model, was selected to determine these fair values, which were calculated as a series of call options on the potential enterprise value of the Company at different valuation points at which the claims of the different
stakeholder groups on the enterprise value would change. The results of the Black-Scholes model were affected by the Companys stock price, as well as assumptions regarding a number of highly subjective variables. These variables included the
expected term of the financial instruments and the Companys expected stock price volatility, risk-free interest rate and dividend rate over the expected term. On June 30, 2010, the Company completed the third and final closing of the
Private Placement. In conjunction with this common equity closing, each of the outstanding shares of Series A convertible preferred stock issued in the initial and second closings of the Private Placement were converted into shares of common
stock.

In October 2010, the Company completed the 2010 Offering (see Note 9), in which the Company sold its common stock and
warrants to purchase its common stock for aggregate gross proceeds of $15.5 million. Due to the potential for the warrants to be settled in cash upon the occurrence of certain transactions specified in the warrant agreements, the warrants are being
accounted for as a derivative liability as opposed to permanent equity. Outstanding warrants under this arrangement are revalued to their fair value each period end, with the change in fair value recorded to other income (expense) in the statement
of operations. As of December 31, 2010, the fair value of the warrants was $8.2 million. During the year ended December 31, 2010, the Company recorded $3.7 million in other income (expense) related to the change in the fair value of the
warrants from the date of their issuance through December 31, 2010.

Revenue Recognition

Revenue arrangements with multiple deliverables are accounted for in accordance with the Financial Accounting Standards Board Accounting
Standards Codification, Subtopic 605-25, Multiple-Element Arrangements (ASC 605-25). Under ASC 605-25, revenue arrangements with multiple deliverables are divided into separate units of accounting based on whether certain criteria
are met, including whether the delivered item



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has stand-alone value to the customer and whether there is objective and reliable evidence of the fair value of the undelivered items. Consideration is allocated among the separate units of
accounting based on their respective fair value, and the applicable revenue recognition is applied to each of the separate units.

Non-refundable fees where the Company has no continuing performance obligations are recognized as revenues when collection is reasonably assured. In situations where continuing performance obligations
exist, nonrefundable fees are deferred and recognized ratably over the projected performance period.

Research funding from
collaborations is recognized as revenue as the related research services are performed. This funding is generally based on a specified amount per full-time equivalent employee per year.

Milestone payments which are substantive and at risk at the time of the execution of the collaboration agreement are recognized upon
completion of the applicable milestone event. Any future royalty revenue will be recognized based on reported product sales by third-party licensees.

Research and Development

All research and development costs,
including those funded by third parties, are expensed as incurred. Research and development expenses consist primarily of costs related to employee salaries and benefits, clinical trials (including amounts paid to contract research organizations
(CROs), and participating clinical trial sites), consultants, outside services (including drug manufacturing), and facilities.

Clinical Trial Accounting

The Company records accruals for
estimated clinical trial costs, which include payments for work performed by CROs, and participating clinical trial sites. These costs are generally a significant component of research and development expenses. Costs incurred for setting up clinical
trial sites for participation in trials are generally non-refundable, and are expensed immediately, with any refundable advances related to enrollment of the first patient recorded as prepayments and assessed for recoverability on a quarterly basis.
Costs related to patient enrollment are accrued as patients progress through the clinical trial, including amortization of any first-patient prepayments. This amortization generally matches when the related services are rendered, however, these cost
estimates may or may not match the actual costs incurred by the CROs or clinical trial sites, and if the Company has incomplete or inaccurate information, the clinical trial accruals may not be accurate. The difference between accrued expenses based
on the Companys estimates and actual expenses have not been material to date.

Stock-Based Compensation

The Company grants options to purchase common stock to its employees, directors and consultants under its stock
option plans. Under the Companys Employee Stock Purchase Plan, eligible employees can also purchase shares of common stock at 85% of the lower of the fair market value of the Companys common stock at the beginning of a 12-month offering
period or at the end of one of the two related six-month purchase periods.

The Company values these share-based awards using
the Black-Scholes option valuation model (the Black-Scholes model). The determination of fair value of share-based payment awards on the date of grant using the Black-Scholes model is affected by the Companys stock price as well as
assumptions regarding a number of highly complex and subjective variables. These variables include, but are not limited to, the expected stock price volatility over the term of the awards and actual and projected employee stock option exercise
behaviors and related estimated forfeitures.



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Foreign Currency

Transactions that are denominated in a foreign currency are translated into U.S. dollars at the current exchange rate on the date of the
transaction. Any foreign currency-denominated monetary assets and liabilities are subsequently remeasured at current exchange rates as of each balance sheet date, with gains or losses on foreign exchange recognized in other income (expense) in
the statement of operations.

Income Taxes

The Company accounts for income taxes under the liability method. Under this method, deferred tax assets and liabilities are determined
based on the differences between the tax basis of assets and liabilities and their basis for financial reporting. Deferred tax assets or liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which
temporary differences are expected to be recovered or settled. Valuation allowances are established when necessary to reduce deferred tax assets to the amounts expected to be realized. The Companys policy is to recognize interest charges and
penalties as other expense.

Comprehensive Loss

The Company displays comprehensive loss and its components within the statements of stockholders equity, net of related tax
effects. Comprehensive loss is comprised of net loss and unrealized gains or losses on available-for-sale securities.

2. Loss per Common
Share

Basic loss per common share is calculated by dividing loss attributable to common stockholders by the
weighted-average number of common shares outstanding for the period. Diluted loss per common share is computed by dividing loss attributable to common stockholders by the weighted-average number of common shares outstanding for the period plus
dilutive potential common shares as determined using the as-if converted method for convertible preferred stock and the treasury stock method for options and warrants to purchase common stock. Convertible preferred stock, options and warrants to
purchase common stock have been excluded from the calculation of diluted loss per common share as their effect is anti-dilutive.

The following tables set forth the computation of basic and diluted loss per common share and the excluded potential common shares for outstanding securities as of the related period end dates:



|                                                                            |  |                         |             |   |      |   |             |      |  |   |             |  
|--------------------------------------------------------------------------- |  | ----------------------- | ----------- | - | ---- | - | ----------- | ---- |  | - | ----------- | -
|                                                                            |  | Year Ended December 31, |            
|                                                                            |  | 2010                    |             |   | 2009 |   |             | 2008 | 
|Numerator:                                                                  |  |                         |             |   |      |   |             |      |  |   |             |  
|Net loss                                                                    |  | $                       | (24,587,485 | ) |      | $ | (40,226,046 | )    |  | $ | (37,185,627 | )
|Deemed distribution to preferred stockholders                               |  |                         |            |   |      |   | (27,563,400 | )    |  |   |            |  
|                                                                            |  |                         |             |   |      |   |             |      |  |   |             |  
|Loss attributable to common stockholders                                    |  | $                       | (24,587,485 | ) |      | $ | (67,789,446 | )    |  | $ | (37,185,627 | )
|                                                                            |  |                         |            
|Denominator:                                                                |  |                         |             |   |      |   |             |      |  |   |             |  
|Weighted-average common shares outstanding                                  |  |                         | 24,860,212  |   |      |   | 5,746,786   |      |  |   | 5,731,196   |  
|                                                                            |  |                         |             |   |      |   |             |      |  |   |             |  
|Basic and diluted loss attributable to common stockholders per common share |  | $                       | (0.99       | ) |      | $ | (11.80      | )    |  | $ | (6.49       | )
|                                                                            |  |                         |             |   |      |   |             |      |  |   |             |  
|                                                                            | 
|                                                                            |  | As of December 31,      |            
|                                                                            |  | 2010                    |             |   | 2009 |   |             | 2008 | 
|Outstanding securities not included in calculations:                        |  |                         |             |   |      |   |             |      |  |   |             |  
|Convertible preferred stock, as-if converted                                |  |                         |            |   |      |   | 7,246,339   |      |  |   |            |  
|Warrants to purchase common stock                                           |  |                         | 8,647,550   |   |      |   | 7,353,194   |      |  |   | 443,474     |  
|Options to purchase common stock                                            |  |                         | 1,065,332   |   |      |   | 1,067,889   |      |  |   | 775,144     |  
|                                                                            |  |                         |             |   |      |   |             |      |  |   |             |  
|                                                                            |  |                         | 9,712,882   |   |      |   | 15,667,422  |      |  |   | 1,218,618   |  
|                                                                            |  |                         |             |   |      |   |             |      |  |   |             |  



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3. Strategic Collaborations

The table below summarizes collaboration revenues for the periods presented:



|                            |  |                         |        |  |      |   |           |      |  |   |           | 
|--------------------------- |  | ----------------------- | ------ |  | ---- | - | --------- | ---- |  | - | --------- | 
|                            |  | Year Ended December 31, |       
|                            |  | 2010                    |        |  | 2009 |   |           | 2008 | 
|Biogen Idec                 |  | $                       |       |  |      | $ | 1,500,000 |      |  | $ | 4,310,551 | 
|Other                       |  |                         | 27,083 |  |      |   | 50,000    |      |  |   | 606,789   | 
|                            |  |                         |        |  |      |   |           |      |  |   |           | 
|Total collaboration revenue |  | $                       | 27,083 |  |      | $ | 1,550,000 |      |  | $ | 4,917,340 | 
|                            |  |                         |        |  |      |   |           |      |  |   |           | 

In August 2004, the Company entered into a collaboration agreement with Biogen Idec, Inc., or Biogen Idec,
to discover, develop and commercialize small molecule inhibitors of Raf kinase and up to five additional targets that play a role in oncology and immunology indications or in the regulation of the human immune system. Concurrent with the
signing of the agreement, Biogen Idec paid a $7.0 million upfront technology access fee and made a $14.0 million equity investment in the Company through the purchase of the Companys Series C-2 preferred stock, which converted into common
stock upon the Companys initial public offering in September 2005.

Pursuant to the terms of the collaboration agreement,
the Company applied its Tethering technology to generate small molecule leads during the research term, for which it received research funding, which was paid in advance to support some of the Companys scientific personnel. In connection
with the Companys June 2008 restructuring, the parties agreed to terminate the research term and related funding as of June 30, 2008. A total of $20.0 million of research funding was received through this date. The Company had
received a total of $3.0 million in milestone payments for meeting certain preclinical milestones through December 31, 2010, including a $1.5 million milestone for Biogen Idecs selection of a Raf kinase inhibitor development candidate for
the treatment of cancer which was received and recognized in 2009, and a $0.5 million milestone which was received and recognized in 2008.

The Company may in the future receive pre-commercialization milestone payments of up to $60.5 million per target, as well as royalty payments depending on product sales. Potential total royalty
payments may be increased if the Company exercises its option to co-develop and co-promote product candidates for up to two targets worldwide (excluding Japan) and may be reduced if Biogen Idec is required to in-license additional intellectual
property related to certain technology jointly developed under the collaboration agreement in order to commercialize a collaboration product.

In November 2010, Biogen Idec announced that it will seek to spin out or outlicense certain oncology assets, including this collaboration agreement. The Company cannot predict the outcome of this
strategic decision by Biogen Idec or its impact on future development activity under the collaboration agreement or on the Companys prospects for the receipt of milestone or royalty payments under the collaboration agreement.

4. License Agreements

In March 2009, SARcode Corporation, or SARcode, a privately-held biopharmaceutical company, acquired the Companys interest in
all of its LFA-1 patents and related know-how that had previously been licensed to SARcode. The cash consideration of $2.0 million was recorded as revenue in April 2009, once all related materials had been transferred. The Company still holds three
secured convertible promissory notes, with a total principal amount of $1.0 million, which it received upon entry into the initial license agreement in March 2006. The notes are due in 2012 and are convertible into the preferred stock of
SARcode at the Companys option. The Company has yet to record any amounts represented by these notes receivable as revenue, due to the uncertainty of their collectibility.



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5. Financial Instruments

In accordance with applicable GAAP, the fair value of the Companys financial instruments reflect the amounts that would be received to sell an asset or paid to transfer a liability in an orderly
transaction between market participants at the measurement date (i.e. the exit price). A fair value hierarchy is also utilized to prioritize valuation inputs, as follows:



|          |  |                                                                                                                                                                                                                                                                                                                                                                                
|--------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Level 1 - |  | quoted prices in active markets for identical assets and liabilities                                                                                                                                                                                                                                                                                                           
|          | 
|Level 2 - |  | significant observable inputs other than Level 1 inputs, such as quoted prices in active markets for similar assets or liabilities; quoted prices for identical or similar assets
or liabilities in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the asset or liability
|          | 
|Level 3 - |  | unobservable inputs                                                                                                                                                                                                                                                                                                                                                            

The Companys
Level 2 valuations are generally based upon quoted prices in active markets for similar securities, with prices adjusted for yield and number of days to maturity.

As part of the VALOR trial, payables are incurred for services that are originally denominated in foreign currencies, such as services performed outside of the United States by the
Companys primary CRO, by clinical study sites, and for the provision of drug supply to those sites. To manage the risk of future movements in foreign exchange rates that would affect such payables, the Company may
purchase certain European currencies or highly-rated investments denominated in those currencies, subject to similar criteria as for other investments defined in the Companys investment policy. To date, the Company has
purchased Euros and Euro-denominated obligations of foreign governments. These cash, cash equivalent and short-term investment balances are recorded at their fair value based on the current exchange rate as of each
balance sheet date. The resulting gains or losses offset exchange gains or losses on the related payables, both of which are recorded in the Companys statements of operations.

The following table summarizes the fair value of the Companys financial assets measured on a recurring basis as of
December 31, 2010, which were comprised solely of available-for-sale securities with remaining contractual maturities of one year or less:



|                                             |  |             |         |  |               |   |            |                      |  |   |                       |  |  |                     |         |   |  |   |            | 
|-------------------------------------------- |  | ----------- | ------- |  | ------------- | - | ---------- | -------------------- |  | - | --------------------- |  |  | ------------------- | ------- | - |  | - | ---------- | 
|December 31, 2010                            |  | Input Level |         |  | AmortizedCost |   |            | GrossUnrealizedGains |  |   | GrossUnrealizedLosses |  |  | Estimated FairValue |        
|Money market funds                           |  |             | Level 1 |  |               | $ | 14,036,573 |                      |  | $ |                      |  |  | $                   |        |   |  | $ | 14,036,573 | 
|Corporate debt obligations                   |  |             | Level 2 |  |               |   | 20,113,847 |                      |  |   | 174                   |  |  |                     | (21,127 | ) |  |   | 20,092,894 | 
|Commercial paper                             |  |             | Level 2 |  |               |   | 16,986,375 |                      |  |   | 6,850                 |  |  |                     |        |   |  |   | 16,993,225 | 
|Foreign government obligations               |  |             | Level 2 |  |               |   | 2,086,984  |                      |  |   |                      |  |  |                     | (624    | ) |  |   | 2,086,360  | 
|                                             |  |             |         |  |               |   |            |                      |  |   |                       |  |  |                     |         |   |  |   |            | 
|Total available-for-sale securities          |  |             |         |  |               |   | 53,223,779 |                      |  |   | 7,024                 |  |  |                     | (21,751 | ) |  |   | 53,209,053 | 
|Less: amounts classified as cash equivalents |  |             |         |  |               |   | 14,036,573 |                      |  |   |                      |  |  |                     |        |   |  |   | 14,036,573 | 
|                                             |  |             |         |  |               |   |            |                      |  |   |                       |  |  |                     |         |   |  |   |            | 
|Amounts classified as marketable securities  |  |             |         |  |               | $ | 39,187,206 |                      |  | $ | 7,024                 |  |  | $                   | (21,751 | ) |  | $ | 39,172,480 | 
|                                             |  |             |         |  |               |   |            |                      |  |   |                       |  |  |                     |         |   |  |   |            | 



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The following table summarizes the available-for-sale securities that were in an unrealized
loss position as of December 31, 2010, each having been in such a position for less than 12 months, and none deemed to be other-than-temporarily impaired:



|                               |  |                       |         |   |                     |   |            | 
|------------------------------ |  | --------------------- | ------- | - | ------------------- | - | ---------- | 
|December 31, 2010              |  | GrossUnrealizedLosses |         |   | Estimated FairValue |  
|Corporate debt obligations     |  | $                     | (21,127 | ) |                     | $ | 19,579,881 | 
|Foreign government obligations |  |                       | (624    | ) |                     |   | 2,086,360  | 
|                               |  |                       |         |   |                     |   |            | 
|Total                          |  | $                     | (21,751 | ) |                     | $ | 21,666,241 | 
|                               |  |                       |         |   |                     |   |            | 

No significant facts or circumstances have arisen to indicate that there has been any deterioration in the
creditworthiness of the issuers of these securities. The gross unrealized losses are not considered to be significant and have been for relatively short durations. The Company does not intend to sell these securities and it is not more likely than
not that they will need to be sold prior to the recovery of their amortized cost basis. There were no sales of available-for-sale securities in the years ended December 31, 2010, 2009 and 2008.

The Companys financial liabilities that were measured on a recurring basis as of December 31, 2010 were comprised solely of a
warrant liability issued in connection with the 2010 Offering (see Note 9). The fair value of the warrant liability was $8.2 million as of December 31, 2010, which was established based on Level 3 inputs. The fair value was determined using the
Black-Scholes model, which requires inputs such as the expected term of the warrants, share price volatility and risk-free interest rate. These inputs are subjective and generally require significant analysis and judgment to develop.

The fair value of the warrant liability was estimated using the following assumptions as of December 31, 2010:



|                                                                 |  |                  |           |  
|---------------------------------------------------------------- |  | ---------------- | --------- | -
|                                                                 |  | December 31,2010 |          
|Fair market value of Companys common stock                      |  | $                | 3.12      |  
|Exercise price                                                   |  | $                | 2.52      |  
|Expected term (years)                                            |  |                  | 4.8       |  
|Expected volatility                                              |  |                  | 87.6      | %
|Risk-free interest rate                                          |  |                  | 1.9       | %
|Expected dividend yield                                          |  |                  | 0.0       | %
|Estimated fair value per share                                   |  | $                | 2.22      |  
|Shares underlying outstanding warrants classified as liabilities |  |                  | 3,678,798 |  
|                                                                 |  |                  |           |  
|Total estimated fair value of outstanding warrants               |  | $                | 8,153,712 |  
|                                                                 |  |                  |           |  

The following table provides a summary of changes in the fair value of the Companys Level 3 financial
liabilities for the year ended December 31, 2010 (in thousands):



|                                                                             |  |                  |           | 
|---------------------------------------------------------------------------- |  | ---------------- | --------- | 
|                                                                             |  | WarrantLiability |          
|Balance as of December 31, 2009                                              |  |                  |          | 
|Initial fair value of warrant liability                                      |  |                  | 4,489,618 | 
|Change in fair value of warrant liability included in other income (expense) |  |                  | 3,664,094 | 
|                                                                             |  |                  |           | 
|Balance as of December 31, 2010                                              |  | $                | 8,153,712 | 
|                                                                             |  |                  |           | 

As of December 31, 2009, the Company held no financial assets or liabilities that were measured on a
recurring basis other than money market funds of $4.2 million, which were valued based on Level 1 inputs and had no associated unrealized gains or losses.



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6. Property and Equipment

Property and equipment is recorded at cost and consisted of the following as of December 31 of the periods presented:



|                                               |  |      |            |   |      |   |            |  
|---------------------------------------------- |  | ---- | ---------- | - | ---- | - | ---------- | -
|                                               |  | 2010 |            |   | 2009 |  
|Computer equipment and software                |  | $    | 1,063,246  |   |      | $ | 1,054,449  |  
|Furniture and office equipment                 |  |      | 471,549    |   |      |   | 437,912    |  
|Laboratory equipment                           |  |      | 43,534     |   |      |   | 855,678    |  
|Leasehold improvements                         |  |      | 376,388    |   |      |   | 376,388    |  
|                                               |  |      |            |   |      |   |            |  
|                                               |  |      | 1,954,717  |   |      |   | 2,724,427  |  
|Less accumulated depreciation and amortization |  |      | (1,838,529 | ) |      |   | (2,461,316 | )
|                                               |  |      |            |   |      |   |            |  
|Net property and equipment                     |  | $    | 116,188    |   |      | $ | 263,111    |  
|                                               |  |      |            |   |      |   |            |  

7. Other Accrued Liabilities

Other accrued liabilities as of December 31 were as follows:



|                                |  |      |           |  |      |   |         | 
|------------------------------- |  | ---- | --------- |  | ---- | - | ------- | 
|                                |  | 2010 |           |  | 2009 |  
|Accrued outside services        |  | $    | 1,078,793 |  |      | $ | 390,418 | 
|Accrued professional services   |  |      | 292,633   |  |      |   | 359,076 | 
|Other accruals                  |  |      | 8,983     |  |      |   | 39,065  | 
|                                |  |      |           |  |      |   |         | 
|Total other accrued liabilities |  | $    | 1,380,409 |  |      | $ | 788,559 | 
|                                |  |      |           |  |      |   |         | 

8. Commitments and Contingencies

Commitments

The Companys operating lease obligations as of
December 31, 2010 relate to the lease of 15,000 square feet of office space in a building at 395 Oyster Point Boulevard in South San Francisco, California, which is currently the Companys headquarters. The lease was entered into in
December 2006 and expires in April 2013, subject to the Companys option to extend the lease through February 2014. The operating lease agreement provides for increasing monthly rent payment over the lease term.

Aggregate non-cancelable future minimum rental payments under operating leases are as follows:



|                        |  |          |         | 
|----------------------- |  | -------- | ------- | 
|Year Ended December 31: |  | Payments |        
|2011                    |  | $        | 395,215 | 
|2012                    |  |          | 404,441 | 
|2013                    |  |          | 135,326 | 
|                        |  |          |         | 
|                        |  | $        | 934,982 | 
|                        |  |          |         | 

The Company recognizes rent expense on a straight-line basis. The Company recorded rent expense of $0.5
million, $0.8 million and $3.0 million for the years ended December 31, 2010, 2009 and 2008, respectively. Deferred rent balances in the Companys balance sheet represent the difference between actual rent payments and
straight-line rent expense.

Contingencies

From time to time, the Company may be involved in legal proceedings, as well as demands, claims and threatened litigation, which arise in
the normal course of its business or otherwise. The ultimate outcome of any



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litigation is uncertain and unfavorable outcomes could have a negative impact on the Companys results of operations and financial condition. Regardless of outcome, litigation can have an
adverse impact on the Company because of the defense costs, diversion of management resources and other factors. The Company is not currently involved in any material legal proceedings.

9. Stockholders Equity

Preferred Stock

The Company has 10,000,000 shares of authorized preferred stock issuable in one or more series. Upon issuance, the Company can determine
the rights, preferences, privileges and restrictions thereof. These rights, preferences and privileges could include dividend rights, conversion rights, voting rights, terms of redemption, liquidation preferences, sinking fund terms and the number
of shares constituting any series or the designation of such series, any or all of which may be greater than the rights of common stock. There were zero and 724,618 shares of preferred stock outstanding as of December 31, 2010 and 2009,
respectively.

Common Stock

Holders of common stock are entitled to one vote per share on all matters to be voted upon by the stockholders of the Company. Subject to the preferences that may be applicable to any outstanding shares
of preferred stock, the holders of common stock are entitled to receive ratably such dividends, if any, as may be declared by the Board of Directors.

Private Placement

In March 2009, the Company entered into a
securities purchase agreement with accredited investors, including certain members of management, providing for the private placement of up to $15.0 million of units consisting of Series A convertible preferred stock and warrants to purchase
common stock, and up to $28.5 million in common stock, in three closings (collectively, the Private Placement).

The initial closing of $10.0 million of units of the Private Placement was completed in April 2009, and the second closing of $5.0
million of units was completed in October 2009. The warrants have an exercise price of $1.32 per share and a term of seven years from the date of issuance. The net proceeds from the initial closing were $8.8 million, and net proceeds from the
second closing were $4.7 million. In the initial closing, the Company issued 0.5 million shares of Series A convertible preferred stock, which were initially convertible into 4.8 million shares of common stock and warrants to purchase
an aggregate of 4.8 million shares of common stock. In the second closing, the Company issued 0.2 million shares of Series A preferred stock, which were initially convertible into 2.4 million shares of common stock, and warrants to
purchase 2.4 million shares of common stock.

Warrants for an aggregate of 2.3 million and 0.3 million shares
of common stock were net exercised during the years ended December 31, 2010 and 2009, respectively, resulting in the issuance of 1.8 million shares and 0.2 million shares of common stock, respectively. As of December 31, 2010,
warrants issued under the Private Placement for the purchase of 4.6 million shares of common stock were outstanding.

On
June 30, 2010, the Company completed the third and final closing of the Private Placement, issuing 17.3 million shares of common stock to the investors at a purchase price of $1.65 per share, for gross proceeds of $28.5 million and net
proceeds of $26.7 million. In conjunction with this common equity closing, each of the 0.7 million outstanding shares of Series A convertible preferred stock issued in the initial and second closings of the Private Placement were converted
into 10 shares of common stock, and as a result, an additional 7.2 million shares of common stock were issued on June 30, 2010.



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Other Investor Rights

The investors in the Private Placement received a number of additional rights as a result of their convertible preferred stock ownership,
some of which expired upon conversion of the Series A preferred stock into common stock on June 30, 2010. The remaining rights include the right of certain of the investors to designate members of the Companys board of directors.

Accounting Treatment

On January 1, 2010, due to an amendment to the Private Placement agreements effected on October 27, 2009, the Series A convertible preferred stock became potentially redeemable
upon certain events that were outside of the control of the Company, and all Series A convertible preferred stock issued in the Private Placement that was outstanding at that time was reclassified to mezzanine equity, outside of
stockholders equity. On March 29, 2010, as a result of an additional amendment to the Private Placement agreements, the Series A convertible preferred stock was reclassified back into stockholders equity. On May 1, 2010,
the Series A convertible preferred stock again became potentially redeemable upon certain events that were outside of the control of the Company, and all Series A convertible preferred stock issued in the Private Placement that was outstanding at
that time was reclassified outside of stockholders equity. On June 30, 2010, upon conversion of the Series A preferred stock into common stock, the value of the Series A convertible preferred stock was reclassified to common stock and
additional paid-in capital.

Controlled Equity Offering

In January 2010, the Company entered into its first controlled equity offering sales agreement with Cantor Fitzgerald & Co.
(Cantor), pursuant to which the Company could issue and sell shares of its common stock having an aggregate offering price of up to $15.0 million from time to time with Cantor acting as agent and/or principal, subject to certain
conditions. Under this facility, the Company sold an aggregate of 2.6 million shares of common stock in the year ended December 31, 2010, at an average price of $5.67 per share for gross proceeds of $15.0 million. Net proceeds were $14.2
million after deducting Cantors commission and costs to set up the facility. No further shares of common stock can be issued under this facility.

In April 2010, the Company entered into a second controlled equity offering sales agreement with Cantor, pursuant to which the Company could issue and sell shares of its common stock having an aggregate
offering price of up to $20.0 million from time to time through Cantor acting as agent and/or principal. As of December 31, 2010, the Company had sold an aggregate of 3.1 million shares of common stock at an average price of $4.60 per
share for gross proceeds of $14.2 million. Net proceeds were $13.7 million after deducting Cantors commission and costs to set up the facility, of which $0.4 million was received upon settlement in January 2011. As of December 31,
2010, $5.8 million of common stock was available to be sold under this facility, subject to certain conditions as specified in the agreement.

From January 1, 2011 through March 15, 2011, the Company sold an aggregate of 0.6 million shares of common stock through the second controlled equity offering sales agreement with Cantor,
at an average price of approximately $2.90 per share for gross proceeds of $1.8 million. Net proceeds were $1.7 million after deducting Cantors commission. As of March 15, 2011, $4.0 million of common stock was available to be sold under
this facility, subject to certain conditions as specified in the agreement.

2010 Offering

On October 6, 2010, the Company completed an underwritten offering, pursuant to which the Company issued an aggregate of
7.4 million shares of common stock and warrants to purchase 3.7 million shares of common stock, for aggregate gross proceeds of $15.5 million (the 2010 Offering). Net proceeds from the sale were $14.2 million, after deducting
the underwriting discount and offering expenses. The warrants are exercisable beginning six months after issuance at an exercise price of $2.52 per share, and expire five years from the date of issuance.



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The warrants have been classified as a derivative liability in the Companys balance
sheet due to potential cash settlement of the warrants on terms, which do not include a cash limit, and upon the occurrence of certain transactions, as specified in the warrant agreements. The warrants were initially recorded at their fair value of
$4.5 million, which was estimated using the Black-Scholes model. At each subsequent balance sheet date, the estimated fair value of the outstanding warrants is determined using the Black-Scholes model and recorded to the balance sheet, with the
change in fair value recorded to other income (expense) in the statement of operations. As of December 31, 2010, the fair value of the warrants was $8.2 million.

Stock Option Plans

The Company grants options
primarily to: (i) new employees, 25% of which becomes exercisable on the first anniversary of the vesting commencement date, and 1/48thbecomes exercisable each month over the remainder of the four-year vesting period, (ii) existing employees,
1/48thof which becomes exercisable each month following
the date of grant over a period of four years, (iii) new non-employee members of the board of directors, 50% of which becomes exercisable on each of the first and second anniversary of the vesting commencement date, and (iv) continuing
non-employee members of the board of directors, 1/12thof
which becomes exercisable each month following the date of grant over a period of one year.

2005 Equity Incentive Award
Plan

In February 2005, the Board of Directors adopted and, in September 2005, the stockholders approved, the 2005 Equity
Incentive Award Plan (the 2005 Plan). The 2005 Plan is intended to serve as the successor equity incentive program to the 1998 Stock Plan and 2001 Stock Plan. The Company initially reserved a total of 296,566 shares of common stock for
issuance under the 2005 Plan plus shares underlying any options granted under the Companys 1998 Stock Plan or 2001 Stock Plan that expire or are cancelled without having been exercised or are repurchased by the Company pursuant to the terms of
such options.

The number of shares of common stock reserved under the 2005 Plan automatically increases on the first trading
day of each year by an amount equal to the lesser of: (i) 4% of the Companys outstanding shares of common stock on such date, (ii) 180,392 shares, or (iii) an amount determined by the Board of Directors. The maximum
aggregate number of shares which may be issued or transferred over the term of the 2005 Plan is 1,882,352 shares.

On
January 1, 2010, the number of shares of common stock reserved for future issuance under the 2005 Plan was increased by 180,392 shares pursuant to the evergreen provision detailed above. During the year ended December 31, 2010,
options to purchase 64,586 shares of the Companys common stock were granted and 16,255 shares of the Companys common stock were issued under the 2005 Plan. As of December 31, 2010, options and awards for an aggregate of
1,511,966 shares of the Companys common stock had been granted and 355,404 shares were available for future grants under the 2005 Plan.

2006 Employment Commencement Incentive Plan

In November 2005, the Board
of Directors adopted the 2006 Employment Commencement Incentive Plan (the 2006 Plan), which became effective on January 1, 2006. Awards granted pursuant to the 2006 Plan are intended to be inducement awards pursuant to Nasdaq
Marketplace Rule 4350(i)(1)(A)(iv). The 2006 Plan was not subject to the approval of the Companys stockholders. Eligibility to participate in the 2006 Plan is limited to employees who have not previously been employees or directors of the
Company, or following a bona fide period of non-employment by the Company. Additionally, grants awarded to such employees under the 2006 Plan must be made in connection with commencement of employment and must be an inducement material to the person
entering into employment with the Company.

In the year ended December 31, 2010, there was no increase in the number of
shares of common stock reserved for issuance under the 2006 Plan, and no options were granted under the 2006 Plan. As of December 31,



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2010, options to purchase an aggregate of 92,166 shares of the Companys common stock had been granted and 78,459 shares were available for future grants under the 2006 Plan.

Employee Stock Purchase Plan

In February 2005, the Board of Directors adopted and, in September 2005, the stockholders approved the Companys Employee Stock Purchase Plan (the ESPP). The ESPP permits eligible
employees to purchase common stock at a discount through payroll deductions during defined offering periods. Eligible employees can purchase shares of the Companys common stock at 85% of the lower of the fair market value of the common stock
at the beginning of a 12-month offering period or at the end of one of the two related 6-month purchase periods. The Company initially reserved a total of 33,824 shares of common stock for issuance under the ESPP.

The number of shares of common stock reserved under the ESPP automatically increases on the first trading day each year, by an amount
equal to the lesser of: (i) 0.5% of the Companys outstanding shares of common stock on such date, (ii) 22,549 shares, or (iii) a lesser amount determined by the Board of Directors. The maximum aggregate number of shares which
may be issued over the term of the ESPP is 225,491 shares. In addition, no participant in the ESPP may be issued or transferred shares of common stock valued at more than $25,000 per calendar year and no participant may purchase more than 196 shares
during any purchase period.

A total of 3,528 shares were issued under the ESPP during the year ended December 31, 2010.
As of December 31, 2010, 55,553 shares of the Companys common stock had been issued and 35,412 shares were available for future issuance under the ESPP.

Warrants

The Company had the following warrants to purchase common
stock outstanding as of December 31, 2010:



|                           |  |        |           |  |                |   |       |            |  |  |                | 
|-------------------------- |  | ------ | --------- |  | -------------- | - | ----- | ---------- |  |  | -------------- | 
|                           |  | Shares |           |  | Exercise Price |   |       | Expiration | 
|                           |  |        | 362,329   |  |                | $ | 37.26 |            |  |  | March 2013     | 
|                           |  |        | 263       |  |                | $ | 54.60 |            |  |  | June 2013      | 
|                           |  |        | 126       |  |                | $ | 54.60 |            |  |  | June 2014      | 
|                           |  |        | 13,737    |  |                | $ | 54.60 |            |  |  | August 2015    | 
|                           |  |        | 174       |  |                | $ | 54.60 |            |  |  | September 2015 | 
|                           |  |        | 2,876,329 |  |                | $ | 1.32  |            |  |  | April 2016     | 
|                           |  |        | 1,715,794 |  |                | $ | 1.32  |            |  |  | October 2016   | 
|                           |  |        | 3,678,798 |  |                | $ | 2.52  |            |  |  | October 2015   | 
|                           |  |        |           |  |                |   |       |            |  |  |                | 
|Total warrants outstanding |  |        | 8,647,550 |  |                |   |       |            |  |  |                | 
|                           |  |        |           |  |                |   |       |            |  |  |                | 

Reserved Shares

As of December 31, 2010, the Companys shares of common stock reserved for future issuance were as follows:



|                                      |  |                                |         |  |                       |  |           |                      |  |  |            | 
|------------------------------------- |  | ------------------------------ | ------- |  | --------------------- |  | --------- | -------------------- |  |  | ---------- | 
|                                      |  | SharesAvailablefor FutureGrant |         |  | OutstandingSecurities |  |           | Total SharesReserved | 
|Warrants                              |  |                                |        |  |                       |  | 8,647,550 |                      |  |  | 8,647,550  | 
|Stock option plans                    |  |                                | 433,863 |  |                       |  | 1,065,332 |                      |  |  | 1,499,195  | 
|Employee stock purchase plan          |  |                                | 35,412  |  |                       |  |          |                      |  |  | 35,412     | 
|                                      |  |                                |         |  |                       |  |           |                      |  |  |            | 
|Total reserved shares of common stock |  |                                | 469,275 |  |                       |  | 9,712,882 |                      |  |  | 10,182,157 | 
|                                      |  |                                |         |  |                       |  |           |                      |  |  |            | 



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10. Stock-Based Compensation

Overview

Employee stock-based compensation expense is calculated based on the grant-date fair value of awards ultimately expected to vest, reduced for estimated forfeitures, and is recorded on a straight-line
basis over the vesting period of the awards. Forfeitures are estimated at the time of grant, based on historical option cancellation information, and revised in subsequent periods if actual forfeitures differ from those estimates. Employee
stock-based compensation expense related to the Companys stock-based awards was as follows for the periods presented:



|                                                |  |                         |         |  |      |   |           |      |  |   |           | 
|----------------------------------------------- |  | ----------------------- | ------- |  | ---- | - | --------- | ---- |  | - | --------- | 
|                                                |  | Year ended December 31, |        
|                                                |  | 2010                    |         |  | 2009 |   |           | 2008 | 
|Research and development                        |  | $                       | 300,592 |  |      | $ | 226,568   |      |  | $ | 644,549   | 
|General and administrative                      |  |                         | 569,774 |  |      |   | 1,084,377 |      |  |   | 1,265,379 | 
|Restructuring charges                           |  |                         |        |  |      |   |          |      |  |   | 366,637   | 
|                                                |  |                         |         |  |      |   |           |      |  |   |           | 
|Total employee stock-based compensation expense |  | $                       | 870,366 |  |      | $ | 1,310,945 |      |  | $ | 2,276,565 | 
|                                                |  |                         |         |  |      |   |           |      |  |   |           | 

Fair Value of Awards

The Company determines the fair value of stock-based awards on the grant date using the Black-Scholes model, which is impacted by the Companys stock price, as well as assumptions regarding a number
of highly subjective variables. The following table summarizes the weighted-average assumptions used as inputs to the Black-Scholes model, and resulting weighted-average and total estimated grant date fair values of employee stock options granted
during the periods presented:



|                                                           |  |                         |             |   |      |   |             |      |  |   |             |  
|---------------------------------------------------------- |  | ----------------------- | ----------- | - | ---- | - | ----------- | ---- |  | - | ----------- | -
|                                                           |  | Year Ended December 31, |            
|                                                           |  | 2010                    |             |   | 2009 |   |             | 2008 | 
|                                                           |  | Stock Option Plans      |            
|Assumptions:                                               |  |                         |             |   |      |   |             |      |  |   |             |  
|Expected term (years)                                      |  |                         | 4.5         |   |      |   | 4.5         |      |  |   | 5.0         |  
|Expected volatility                                        |  |                         | 90.4        | % |      |   | 86.7        | %    |  |   | 72.4        | %
|Risk-free interest rate                                    |  |                         | 1.7         | % |      |   | 1.9         | %    |  |   | 3.3         | %
|Expected dividend yield                                    |  |                         | 0.0         | % |      |   | 0.0         | %    |  |   | 0.0         | %
|Fair value:                                                |  |                         |             |   |      |   |             |      |  |   |             |  
|Weighted-average estimated grant date fair value per share |  | $                       | 2.10        |   |      | $ | 1.86        |      |  | $ | 5.31        |  
|Options granted to employees                               |  |                         | 57,920      |   |      |   | 675,004     |      |  |   | 141,539     |  
|                                                           |  |                         |             |   |      |   |             |      |  |   |             |  
|Total estimated grant date fair value                      |  | $                       | 0.1 million |   |      | $ | 1.3 million |      |  | $ | 0.8 million |  
|                                                           |  |                         |             |   |      |   |             |      |  |   |             |  

The estimated fair value of stock options that vested in the years ended December 31, 2010, 2009 and
2008, was $0.8 million, $1.2 million and $2.2 million, respectively.



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Purchase rights for 3,528, 3,136 and 7,467 shares were granted under the ESPP during the
years ended December 31, 2010, 2009 and 2008, respectively. The weighted-average estimated fair value of purchase rights granted under the ESPP for the years ended December 31, 2010, 2009 and 2008 was $1.20, $1.92 and $6.54 per share,
respectively, using the Black-Scholes model with the following weighted-average assumptions:



|                        |  |                              |           |   |      |  |           |      |  |  |            |  
|----------------------- |  | ---------------------------- | --------- | - | ---- |  | --------- | ---- |  |  | ---------- | -
|                        |  | Year Ended December 31,      |          
|                        |  | 2010                         |           |   | 2009 |  |           | 2008 | 
|                        |  | Employee Stock Purchase Plan |          
|Expected term (years)   |  |                              | 0.5  1.0 |   |      |  | 0.5  1.0 |      |  |  | 0.5  1.0  |  
|Expected volatility     |  |                              | 132.0     | % |      |  | 157.0     | %    |  |  | 93.4       | %
|Risk-free interest rate |  |                              | 0.27      | % |      |  | 1.1       | %    |  |  | 0.4%  5.1 | %
|Expected dividend yield |  |                              | 0.0       | % |      |  | 0.0       | %    |  |  | 0.0        | %

For employee stock options, the
Company based its assumptions for the expected term on historical cancellation and exercise data, and the contractual term and vesting terms of the awards. Expected volatility is based on historical volatility of the Companys common stock, as
well as that for a mature peer group of companies in the same industry. For employee purchase rights under the ESPP, the expected term is equal to the purchase period. The risk-free interest rate assumptions are based upon observed interest rates
appropriate for the expected life of the Companys employee stock options and employee purchase rights. The Company does not anticipate paying any cash dividends in the foreseeable future, and therefore uses an expected dividend yield of zero.

Option Plan Activity

The following table summarizes stock option activity for the Companys stock option plans in the periods presented:



|                                                    |  |                 |           |   |                              |   |       |                                                 |  |  |                         |  |  |   |         | 
|--------------------------------------------------- |  | --------------- | --------- | - | ---------------------------- | - | ----- | ----------------------------------------------- |  |  | ----------------------- |  |  | - | ------- | 
|                                                    |  | Number ofShares |           |   | WeightedAverageExercisePrice |   |       | WeightedAverageRemainingContractualTerm (Years) |  |  | AggregateIntrinsicValue | 
|Outstanding as of December 31, 2007                 |  |                 | 859,987   |   |                              | $ | 23.05 |                                                 |  |  |                         |  |  |   |         | 
|Options granted                                     |  |                 | 154,041   |   |                              | $ | 9.22  |                                                 |  |  |                         |  |  |   |         | 
|Options canceled, forfeited or expired              |  |                 | (238,884  | ) |                              | $ | 21.85 |                                                 |  |  |                         |  |  |   |         | 
|                                                    |  |                 |           |   |                              |   |       |                                                 |  |  |                         |  |  |   |         | 
|Outstanding as of December 31, 2008                 |  |                 | 775,144   |   |                              | $ | 20.66 |                                                 |  |  |                         |  |  |   |         | 
|Options granted                                     |  |                 | 684,171   |   |                              | $ | 2.82  |                                                 |  |  |                         |  |  |   |         | 
|Options exercised                                   |  |                 | (760      | ) |                              | $ | 8.64  |                                                 |  |  |                         |  |  |   |         | 
|Options canceled, forfeited or expired              |  |                 | (390,656  | ) |                              | $ | 19.06 |                                                 |  |  |                         |  |  |   |         | 
|                                                    |  |                 |           |   |                              |   |       |                                                 |  |  |                         |  |  |   |         | 
|Outstanding as of December 31, 2009                 |  |                 | 1,067,899 |   |                              | $ | 9.83  |                                                 |  |  |                         |  |  |   |         | 
|Options granted                                     |  |                 | 64,586    |   |                              | $ | 3.06  |                                                 |  |  |                         |  |  |   |         | 
|Options exercised                                   |  |                 | (1,250    | ) |                              | $ | 2.94  |                                                 |  |  |                         |  |  |   |         | 
|Options canceled, forfeited or expired              |  |                 | (65,903   | ) |                              | $ | 13.55 |                                                 |  |  |                         |  |  |   |         | 
|                                                    |  |                 |           |   |                              |   |       |                                                 |  |  |                         |  |  |   |         | 
|Outstanding as of December 31, 2010                 |  |                 | 1,065,332 |   |                              | $ | 9.19  |                                                 |  |  | 7.50                    |  |  | $ | 219,311 | 
|                                                    |  |                 |           |   |                              |   |       |                                                 |  |  |                         |  |  |   |         | 
|Vested and expected to vest as of December 31, 2010 |  |                 | 1,020,531 |   |                              | $ | 9.46  |                                                 |  |  | 7.44                    |  |  | $ | 207,968 | 
|Exercisable as of December 31, 2010                 |  |                 | 618,531   |   |                              | $ | 13.25 |                                                 |  |  | 6.63                    |  |  | $ | 110,948 | 

The aggregate
intrinsic value in the table above represents the total pre-tax intrinsic value (i.e., the difference between the Companys closing stock price on the last trading day of the period and the exercise price, multiplied by the number of
in-the-money options) that would have been received by option holders if they had exercised all their options on December 31, 2010.



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The intrinsic value of options exercised during the years ended December 31, 2010, 2009
and 2008 was $3,000, $1,000 and zero, respectively. As the Company believes it is more likely than not that no stock option related tax benefits will be realized, the Company does not record any net tax benefits related to exercised options.

Total estimated unrecognized stock-based compensation cost related to unvested stock options was $0.9 million as of
December 31, 2010, which is expected to be recognized over the respective vesting terms of each award. The weighted average term of the unrecognized stock-based compensation expense is 2.5 years.

11. Restructuring

In
the first quarter of 2009, the Company recorded a restructuring charge of $0.6 million for employee severance and related benefit costs related to a restructuring plan initiated in March 2009. The severance payments were made in the second quarter
of 2009, and other personnel-related expenses such as employee benefits were paid over the remainder of 2009. These charges are included in Restructuring charges in the Companys statement of operations for the year ended
December 31, 2009.

In June 2008, the Company implemented a corporate realignment to focus on the development of
vosaroxin (the 2008 Restructuring). For the year ended December 31, 2008, the Company recorded total charges of $5.9 million related to the 2008 Restructuring, including $3.5 million for employee severance and related benefits, $1.6
million for asset impairments, and $0.8 million for other facility closure expenses. For the year ended December 31, 2009, the Company recorded net charges of $1.3 million for the 2008 Restructuring, including $2.2 million for lease termination
fees and $0.4 million for third-party commissions, partially offset by the reversal of $1.4 million of deferred rent. No liability remained as of December 31, 2009.

12. Income Taxes

No provision for income taxes was recorded in the
periods presented due to tax losses incurred in each period. The income tax provision differs from the amount computed by applying the statutory income tax rate of 34% to pre-tax loss as follows:



|                                                                                                   |  |                         |            |   |      |   |             |      |  |   |             |  
|-------------------------------------------------------------------------------------------------- |  | ----------------------- | ---------- | - | ---- | - | ----------- | ---- |  | - | ----------- | -
|                                                                                                   |  | Year Ended December 31, |           
|                                                                                                   |  | 2010                    |            |   | 2009 |   |             | 2008 | 
|Tax at statutory rate                                                                              |  | $                       | (8,359,472 | ) |      | $ | (13,676,582 | )    |  | $ | (12,642,344 | )
|Current year net operating losses and temporary differences for which no tax benefit is recognized |  |                         | 6,972,997  |   |      |   | 6,340,457   |      |  |   | 12,223,875  |  
|Non-cash expense related to financings                                                             |  |                         | 1,245,792  |   |      |   | 7,145,779   |      |  |   |            |  
|Other permanent differences                                                                        |  |                         | 140,683    |   |      |   | 190,346     |      |  |   | 418,469     |  
|                                                                                                   |  |                         |            |   |      |   |             |      |  |   |             |  
|Provision for income taxes                                                                         |  | $                       |           |   |      | $ |            |      |  | $ |            |  
|                                                                                                   |  |                         |            |   |      |   |             |      |  |   |             |  



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Deferred income taxes reflect the net tax effects of loss and credit carry-forwards and
temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. Significant components of the Companys deferred tax assets for federal and state income
taxes are as follows:



|                                                 |  |              |              |   |      |   |              |  
|------------------------------------------------ |  | ------------ | ------------ | - | ---- | - | ------------ | -
|                                                 |  | December 31, |             
|                                                 |  | 2010         |              |   | 2009 |  
|Deferred tax assets:                             |  |              |              |   |      |   |              |  
|Net operating loss carry-forwards                |  | $            | 95,547,000   |   |      | $ | 87,303,000   |  
|Federal and state research credit carry-forwards |  |              | 9,660,000    |   |      |   | 8,852,000    |  
|Capitalized research costs                       |  |              | 5,098,000    |   |      |   | 5,181,000    |  
|Property and equipment                           |  |              | 183,000      |   |      |   | 181,000      |  
|Accrued liabilities                              |  |              | 1,808,000    |   |      |   | 1,857,000    |  
|                                                 |  |              |              |   |      |   |              |  
|Gross deferred tax assets                        |  |              | 112,296,000  |   |      |   | 103,374,000  |  
|Valuation allowance                              |  |              | (112,296,000 | ) |      |   | (103,374,000 | )
|                                                 |  |              |              |   |      |   |              |  
|Net deferred tax assets                          |  | $            |             |   |      | $ |             |  
|                                                 |  |              |              |   |      |   |              |  

Realization of the deferred tax assets is dependent upon future taxable income, if any, the amount and
timing of which are uncertain. Accordingly, the net deferred tax assets have been fully offset by a valuation allowance. The net valuation allowance increased by approximately $8.9 million, $7.7 million and $15.0 million during the years
ended December 31, 2010, 2009 and 2008, respectively.

As of December 31, 2010, the Company had federal net
operating loss carry-forwards of $253.6 million and federal research and development tax credit carry-forwards of $5.8 million. If not utilized, the federal net operating loss and tax credit carry-forwards will expire at various dates
beginning in 2018. As of December 31, 2010, the Company had state net operating loss carry-forwards of $155.6 million, which begin to expire in 2012, and state research and development tax credit carry-forwards of $5.6 million, which
do not expire.

Utilization of these net operating loss and tax credits carry-forwards may be subject to a substantial annual
limitation due to the ownership change rules under Section 382 of the Internal Revenue Code of 1986, as amended (the Code). The limitations are applicable if an ownership change, as defined in the Code, is deemed to have
occurred or occurs in the future. The annual limitation may result in the expiration of net operating loss and credit carry-forwards before they can be utilized.

The Company recognizes the financial statement effect of tax positions when it is more likely than not that the tax positions will be sustained upon examination by the appropriate taxing authorities. As
of December 31, 2010 and 2009, the Company had no unrecognized tax positions.

The Company files U.S. federal and
California tax returns. The Companys wholly owned subsidiary files tax returns in the United Kingdom. To date, neither the Company nor its wholly owned subsidiary has been audited by the Internal Revenue Service, any state income tax
authority or tax authority in the United Kingdom. Due to net operating loss carry-forwards, substantially all of the Companys tax years remain open to federal tax examination. The tax return for California is subject to a four year statute of
limitations.

13. Guarantees and Indemnification

As permitted under Delaware law and in accordance with the Companys Bylaws, the Company indemnifies its officers and directors for certain events or occurrences, subject to certain limits, while the
officer or director is or was serving at the Companys request in such capacity. The indemnification agreements with the Companys officers and directors terminate upon termination of their employment, but the termination does not affect
claims for indemnification relating to events occurring prior to the effective date of termination. The



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maximum amount of potential future indemnification is unlimited; however, the Companys officer and director insurance policy reduces the Companys exposure and may enable the Company
to recover a portion of any future amounts paid. The Company believes that the fair value of these indemnification agreements is minimal. In addition, in the ordinary course of business the Company enters into agreements, such as licensing
agreements, clinical trial agreements and certain services agreements, containing standard indemnifications provisions. The Company believes that the likelihood of an adverse judgment related to such indemnification provisions is remote.
Accordingly, the Company has not recorded any liabilities for any of these agreements as of December 31, 2010.

14. Selected Quarterly
Financial Data (unaudited)



|                                                                                                     |  |                    |            |   |              |   |            |              |  |   |              |   |  |              |             |   |              |   |            |              |  |   |              |   |  |   |            |   |  |   |            |  
|---------------------------------------------------------------------------------------------------- |  | ------------------ | ---------- | - | ------------ | - | ---------- | ------------ |  | - | ------------ | - |  | ------------ | ----------- | - | ------------ | - | ---------- | ------------ |  | - | ------------ | - |  | - | ---------- | - |  | - | ---------- | -
|                                                                                                     |  | Three Months Ended |           
|                                                                                                     |  | Mar. 31,2010       |            |   | June 30,2010 |   |            | Sep. 30,2010 |  |   | Dec. 31,2010 |   |  | Mar. 31,2009 |             |   | June 30,2009 |   |            | Sep. 30,2009 |  |   | Dec. 31,2009 |  
|Revenue                                                                                              |  | $                  | 12,500     |   |              | $ | 14,583     |              |  | $ |             |   |  | $            |            |   |              | $ | 224,047    |              |  | $ | 3,512,500    |   |  | $ | 12,500     |   |  | $ | 12,500     |  
|Net loss                                                                                             |  | $                  | (4,647,682 | ) |              | $ | (4,783,947 | )            |  | $ | (5,084,034   | ) |  | $            | (10,071,822 | ) |              | $ | (8,363,436 | )            |  | $ | (22,878,464  | ) |  | $ | (4,949,074 | ) |  | $ | (4,035,072 | )
|Deemed distribution to preferred stockholders                                                        |  | $                  |           |   |              | $ |           |              |  | $ |             |   |  | $            |            |   |              | $ |           |              |  | $ | (26,375,000  | ) |  | $ |           |   |  | $ | (1,188,400 | )
|Loss attributable to common stockholders                                                             |  | $                  | (4,647,682 | ) |              | $ | (4,783,947 | )            |  | $ | (5,084,034   | ) |  | $            | (10,071,822 | ) |              | $ | (8,363,436 | )            |  | $ | (49,253,464  | ) |  | $ | (4,949,074 | ) |  | $ | (5,223,472 | )
|Basic and diluted loss attributable to common stockholders per common share                          |  | $                  | (0.65      | ) |              | $ | (0.44      | )            |  | $ | (0.14        | ) |  | $            | (0.23       | ) |              | $ | (1.46      | )            |  | $ | (8.59        | ) |  | $ | (0.86      | ) |  | $ | (0.90      | )
|Shares used in computing basic and diluted loss attributable to common stockholders per common share |  |                    | 7,142,434  |   |              |   | 10,912,203 |              |  |   | 36,969,986   |   |  |              | 43,879,448  |   |              |   | 5,734,961  |              |  |   | 5,735,478    |   |  |   | 5,736,530  |   |  |   | 5,779,792  |  



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|ITEM 9. | CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE
|------- | ------------------------------------------------------------------------------------

Not applicable.



|ITEM 9A. | CONTROLS AND PROCEDURES
|-------- | -----------------------

Disclosure Controls and Procedures

Based on their evaluation as of
December 31, 2010, our Chief Executive Officer and Chief Financial Officer, with the participation of management, have concluded that, subject to the limitations described below, our disclosure controls and procedures (as defined in
Rules 13a-15(e) and 15d-15(e) of the Securities Exchange Act) were effective at the reasonable assurance level.

Managements Report on Internal Control over Financial Reporting

Our management is responsible for establishing and maintaining adequate internal control over financial reporting, as defined in
Rules 13a-15(f) and 15d-15(f) under the Securities Exchange Act. Internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial
statements for external purposes in accordance with generally accepted accounting principles in the United States.

Under the
supervision and with the participation of our management, including our Chief Executive Officer and Chief Financial Officer, we conducted an evaluation of the effectiveness of our internal control over financial reporting as of December 31,
2010. Management based its assessment on the criteria set forth by the Committee of Sponsoring Organizations of the Treadway Commission in Internal ControlIntegrated Framework. Based on this evaluation, our management concluded
that as of December 31, 2010, our internal control over financial reporting was effective.

The Companys internal
control over financial reporting was not subject to attestation by the Companys registered public accounting firm pursuant to the rules of the Securities and Exchange Commission that permit the Company, as a non-accelerated filer, to provide
only managements report in this annual report.

Changes in Internal Control over Financial Reporting

There were no changes in our internal control over financial reporting during the quarter ended December 31,
2010 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

Limitations on the Effectiveness of Controls

Our disclosure
controls and procedures provide our Chief Executive Officer and Chief Financial Officer with only reasonable assurances that our disclosure controls and procedures will achieve their objectives. However, our management, including our Chief Executive
Officer and Chief Financial Officer, does not expect that our disclosure controls and procedures or our internal control over financial reporting can or will prevent all human error. A control system, no matter how well designed and implemented, can
provide only reasonable, not absolute, assurance that the objectives of the control system are met. Furthermore, the design of a control system must reflect the fact that there are internal resource constraints, and the benefit of controls must be
weighed relative to their corresponding costs. Because of the limitations in all control systems, no evaluation of controls can provide complete assurance that all control issues and instances of error, if any, within our company are detected. These
inherent limitations include the realities that judgments in decision-making can be faulty, and that breakdowns can occur due to human error or mistake. Additionally, controls, no matter how well



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designed, could be circumvented by the individual acts of specific persons within the organization. The design of any system of controls is also based in part upon certain assumptions about the
likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated objectives under all potential future conditions.



|ITEM 9B. | OTHER INFORMATION
|-------- | -----------------

None.



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PART III

Certain information required by Part III is omitted from this report because we will file with the SEC a definitive proxy statement pursuant to Regulation 14A, or the Proxy Statement, not later
than 120 days after the year ended December 31, 2010, and certain information included therein is incorporated herein by reference.



|ITEM 10. | DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE
|-------- | ------------------------------------------------------

Information responsive to this item regarding directors and director nominees, executive officers, the board of directors and its
committees, and certain corporate governance matters is incorporated herein by reference to the information set forth under the captions Election of Nominees to the Board of Directors, Information About the Board of Directors and
Corporate Governance and Certain Information with Respect to Executive Officers in our definitive Proxy Statement.

Code
of Business Conduct & Ethics

We have adopted a Code of Business Conduct & Ethics which applies to all
of our directors, officers and employees. A copy of our Code of Business Conduct & Ethics can be found on our website, www.sunesis.com, in the section titled Investors and Media under the subsection titled
Corporate Governance. Information found on our website is not incorporated by reference into this report. In addition, we intend to promptly disclose (1) the nature of any amendment to our Code of Business Conduct &
Ethics that applies to our principal executive officer, principal financial officer, principal accounting officer or persons performing similar functions and (2) the nature of any waiver, including an implicit waiver, from a provision of our
Code of Business Conduct & Ethics that is granted to one of these specified officers, the name of such person who is granted the waiver and the date of the waiver on our website in the future.

All additional information required by this Item 10 will be set forth in our definitive Proxy Statement and is incorporated in this
report by reference.



|ITEM 11. | EXECUTIVE COMPENSATION
|-------- | ----------------------

Information responsive to this item is incorporated herein by reference to the information set forth under the captions Executive Compensation and Related Information and Information
About the Board of Directors and Corporate Governance in our definitive Proxy Statement.



|ITEM 12. | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS
|-------- | ----------------------------------------------------------------------------------------------

Ownership of Sunesis Securities

Information responsive to this item is incorporated herein by reference to the information set forth under the caption Security Ownership of Certain Beneficial Owners and Management in our
definitive Proxy Statement.



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Equity Compensation Plan Information

The following table provides certain information with respect to our equity compensation plans in effect as of December 31, 2010:



|                                                          |  |                                                                      |           |     |                                                      |   |      |                                                                                                                                       |  |  |         |    
|--------------------------------------------------------- |  | -------------------------------------------------------------------- | --------- | --- | ---------------------------------------------------- | - | ---- | ------------------------------------------------------------------------------------------------------------------------------------- |  |  | ------- | ---
|                                                          |  | (A)                                                                  |           |     | (B)                                                  |   |      | (C)                                                                                                                                   | 
|Plan Category                                             |  | Number of Securitiesto be Issued uponExercise ofOutstanding 
Options |           |     | Weighted AverageExercise Price ofOutstanding Options |   |      | Number of SecuritiesRemaining Available forFuture Issuance 
UnderEquity Compensation Plans(Excluding SecuritiesReflected in Column A) | 
|Equity Compensation Plans Approved by Stockholders(1)     |  |                                                                      | 1,039,624 | (2) |                                                      | $ | 9.20 |                                                                                                                                       |  |  | 390,816 | (3)
|Equity Compensation Plans Not Approved by Stockholders(4) |  |                                                                      | 25,708    |     |                                                      | $ | 9.12 |                                                                                                                                       |  |  | 78,459  |    
|                                                          |  |                                                                      |           |     |                                                      |   |      |                                                                                                                                       |  |  |         |    
|Total                                                     |  |                                                                      | 1,065,332 |     |                                                      | $ | 9.19 |                                                                                                                                       |  |  | 469,275 |    
|                                                          |  |                                                                      |           |     |                                                      |   |      |                                                                                                                                       |  |  |         |    



|(1) | Includes securities issuable under our 2005 Equity Incentive Award Plan, or 2005 Plan, and Employee Stock Purchase Plan, or ESPP.
|--- | ---------------------------------------------------------------------------------------------------------------------------------



|(2) | Excludes purchase rights currently accruing under the ESPP. Offering periods under the ESPP are 12-month periods, which are comprised of two six-month purchase periods.
Eligible employees may purchase shares of common stock at a price equal to 85% of the lower of the fair market value of the common stock at the beginning of each offering period or the end of each semi-annual purchase period. Participation is
limited to 20% of an employees eligible compensation, subject to limitations under the Internal Revenue Code.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | Includes (i) 355,404 shares of common stock available for issuance under our 2005 Plan and (ii) 35,412 shares of common stock available for issuance under our
ESPP. Beginning in 2006, the number of shares of common stock reserved under the 2005 Plan automatically increases on the first trading day each year by an amount equal to the lesser of: (i) 4% of the Companys outstanding shares
of common stock outstanding on such date, (ii) 180,392 shares, or (iii) an amount determined by the Board of Directors. The number of shares of common stock reserved under our ESPP automatically increases on the first trading day each year
by an amount equal to the least of: (i) 0.5% of our outstanding shares of common stock outstanding on such date, (ii) 22,549 or (iii) a lesser amount determined by our Board of Directors.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|(4) | Represents our 2006 Employment Commencement Incentive Plan.
|--- | -----------------------------------------------------------

The additional information required by this Item 12 concerning our non-stockholder approved equity compensation plans is discussed in the notes to our consolidated financial statements contained in
Part II, Item 8 of this report and is incorporated herein by reference. Any other information required by this Item 12 will be set forth in our definitive Proxy Statement and is incorporated in this report by reference.



|ITEM 13. | CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE
|-------- | -------------------------------------------------------------------------

Information responsive to this item is incorporated herein by reference to the information set forth under the captions Certain
Relationships and Related Party Transactions and Information About the Board of Directors and Corporate Governance in our definitive Proxy Statement.



|ITEM 14. | PRINCIPAL ACCOUNTING FEES AND SERVICES
|-------- | --------------------------------------

Information responsive to this item is incorporated herein by reference to the information set forth under the caption Independent Registered Public Accounting Firm in our definitive Proxy
Statement.



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PART IV



|ITEM 15. | EXHIBITS AND FINANCIAL STATEMENT SCHEDULES
|-------- | ------------------------------------------

Exhibits and Financial Statement Schedules:



| | (a)(1) | Financial Statements
| | ------ | --------------------



|                                                        |  |      |    | 
|------------------------------------------------------- |  | ---- | -- | 
|                                                        |  | Page |   
|Report of Independent Registered Public Accounting Firm |  |      | 50 | 
|Consolidated Balance Sheets                             |  |      | 51 | 
|Consolidated Statements of Operations                   |  |      | 52 | 
|Consolidated Statements of Stockholders Equity         |  |      | 53 | 
|Consolidated Statements of Cash Flows                   |  |      | 54 | 
|Notes to Consolidated Financial Statements              |  |      | 55 | 



| | (a)(2) | Financial Statement Schedules
| | ------ | -----------------------------

All financial statement schedules are omitted because they are not applicable, or the information is included in the financial
statements or notes thereto.



| | (a)(3) | Exhibits
| | ------ | --------

A list of exhibits
filed with this report or incorporated herein by reference is found in the Exhibit Index immediately following the signature page of this report.



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SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, Sunesis Pharmaceuticals, Inc. has
duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized on March 29, 2011.



SUNESIS PHARMACEUTICALS, INC.By:

/ S /    ERIC H.
BJERKHOLTEric H. BjerkholtSenior Vice President, Corporate Developmentand Finance, Chief Financial Officer


KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Daniel N. Swisher, Jr. and Eric H. Bjerkholt, and each of them, as his true and lawful
attorneys-in-fact and agents, with full power of substitution for him, and in his name in any and all capacities, to sign any and all amendments to this Annual Report on Form 10-K, and to file the same, with exhibits thereto and other documents
in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done
therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, and any of them or his substitute or substitutes, may lawfully do or cause to be done by
virtue hereof.

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the
following persons on behalf of the registrant and in the capacities on the dates indicated.



|                                                       |  |                                                                                                                                                  |  |               
|------------------------------------------------------ |  | ------------------------------------------------------------------------------------------------------------------------------------------------ |  | --------------
|Signature                                              |  | Title                                                                                                                                            |  | Date          
|                                                       |  |                                                                                                                                                 
|/ S /    JAMES W. YOUNG,
PH.D. James W. Young, Ph.D.   |  | Chairman of the Board                                                                                                                            |  | March 29, 2011
|                                                       |  |                                                                                                                                                 
|/ S /    DANIEL N.
SWISHER, JR. Daniel N. Swisher,
Jr. |  | President, Chief Executive Officer and Director (Principal Executive Officer)                                                                    |  | March 29, 2011
|                                                       |  |                                                                                                                                                 
|/ S /    ERIC H.
BJERKHOLT Eric H. Bjerkholt           |  | Senior Vice President, Corporate
Development and Finance, Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer) |  | March 29, 2011
|                                                       |  |                                                                                                                                                 
|/ S /    MATTHEW K.
FUST Matthew K. Fust               |  | Director                                                                                                                                         |  | March 29, 2011
|                                                       |  |                                                                                                                                                 
|/ S /    EDWARD
HURWITZ Edward Hurwitz                 |  | Director                                                                                                                                         |  | March 29, 2011
|                                                       |  |                                                                                                                                                 
|/ S /    HELEN S.
KIM Helen S. Kim                     |  | Director                                                                                                                                         |  | March 29, 2011
|                                                       |  |                                                                                                                                                 
|/ S /    DAYTON
MISFELDT Dayton Misfeldt               |  | Director                                                                                                                                         |  | March 29, 2011
|                                                       |  |                                                                                                                                                 
|Homer L. Pearce Ph.D.                                  |  | Director                                                                                                                                         |  |               
|                                                       |  |                                                                                                                                                 
|/ S /    DAVID C.
STUMP,M.D. David C. Stump, M.D.      |  | Director                                                                                                                                         |  | March 29, 2011



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EXHIBIT INDEX



|              |  |                                                                                                                                          |  |                           |  |            |  |         |       |  |             |  |            |               |  |  |   | 
|------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------- |  | ------------------------- |  | ---------- |  | ------- | ----- |  | ----------- |  | ---------- | ------------- |  |  | - | 
|              |  |                                                                                                                                          |  | Incorporated By Reference |  |            |  |        
|ExhibitNumber |  | Exhibit Description                                                                                                                      |  | Form                      |  | File No.   |  | Exhibit |       |  | Filing Date |  |            | FiledHerewith | 
|3.1           |  | Amended and Restated Certificate of Incorporation of the Registrant                                                                      |  | 10-K/A                    |  | 000-51531  |  |         | 3.1   |  |             |  | 5/23/2007  |               |  |  |   | 
|3.2           |  | Amended and Restated Bylaws of the Registrant                                                                                            |  | 8-K                       |  | 000-51531  |  |         | 3.2   |  |             |  | 12/11/2007 |               |  |  |   | 
|3.3           |  | Certificate of Designation of the Series A Preferred Stock of the Registrant                                                             |  | 8-K                       |  | 000-51531  |  |         | 3.3   |  |             |  | 4/3/2009   |               |  |  |   | 
|3.4           |  | Certificate of Amendment to the Amended and Restated Certificate of Incorporation of the Registrant                                      |  | S-8                       |  | 333-160528 |  |         | 3.4   |  |             |  | 7/10/2009  |               |  |  |   | 
|3.5           |  | Certificate of Amendment to the Certificate of Designation of the Series A Preferred Stock of the Registrant                             |  | 8-K                       |  | 000-51531  |  |         | 3.4   |  |             |  | 11/2/2009  |               |  |  |   | 
|3.6           |  | Certificate of Amendment to the Certificate of Designation of the Series A Preferred stock of the Registrant                             |  | 8-K                       |  | 000-51531  |  |         | 3.5   |  |             |  | 1/21/2010  |               |  |  |   | 
|3.7           |  | Certificate of Amendment to the Amended and Restated Certificate of Incorporation of the Registrant                                      |  | 8-K                       |  | 000-51531  |  |         | 3.1   |  |             |  | 2/14/2011  |               |  |  |   | 
|4.1           |  | Reference is made to Exhibits 3.1, 3.2, 3.3, 3.4, 3.5, 3.6 and 3.7 above.                                                                |  |                           |  |            |  |         |       |  |             |  |            |               |  |  |   | 
|4.2           |  | Specimen Common Stock certificate of the Registrant                                                                                      |  |                           |  |            |  |         |       |  |             |  |            |               |  |  | X | 
|4.3           |  | Investor Rights Agreement, dated April 3, 2009, by and among the Registrant and the purchasers identified on the signature pages
thereto |  | 8-K                       |  | 000-51531  |  |         | 4.1   |  |             |  | 4/3/2009   |               |  |  |   | 
|10.1*         |  | 1998 Stock Plan and Form of Stock Option Agreement                                                                                       |  | S-1/A                     |  | 333-121646 |  |         | 10.1  |  |             |  | 1/27/2005  |               |  |  |   | 
|10.2*         |  | 2001 Stock Plan and Form of Stock Option Agreement                                                                                       |  | S-1                       |  | 333-121646 |  |         | 10.2  |  |             |  | 12/23/2004 |               |  |  |   | 
|10.3*         |  | 2005 Equity Incentive Award Plan, as amended, and Form of Stock Option Agreement                                                         |  | 10-K/A                    |  | 000-51531  |  |         | 10.3  |  |             |  | 4/30/2009  |               |  |  |   | 
|10.4*         |  | Employee Stock Purchase Plan and Enrollment Form                                                                                         |  | 10-Q                      |  | 000-51531  |  |         | 10.4  |  |             |  | 11/9/2006  |               |  |  |   | 
|10.5*         |  | Form of Indemnification Agreement for directors and executive officers                                                                   |  | S-1                       |  | 333-121646 |  |         | 10.5  |  |             |  | 12/23/2004 |               |  |  |   | 
|10.6          |  | Warrant, dated June 11, 2003, issued to General Electric Capital Corporation                                                             |  | S-1                       |  | 333-121646 |  |         | 10.21 |  |             |  | 12/23/2004 |               |  |  |   | 
|10.7          |  | Warrant, dated June 21, 2004, issued to General Electric Capital Corporation and Amendment No. 1 thereto, dated December 16,
2004        |  | S-1/A                     |  | 333-121646 |  |         | 10.22 |  |             |  | 4/29/2005  |               |  |  |   | 
|10.8         |  | Collaboration Agreement, dated December 18, 2002, by and between the Registrant and Biogen Idec MA Inc. (successor to Biogen
Inc.)       |  | S-1/A                     |  | 333-121646 |  |         | 10.26 |  |             |  | 1/27/2005  |               |  |  |   | 



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|              |  |                                                                                                                                                                                                                 |  |                           |  |            |  |         |       |  |             |  |           |               |  |  |   | 
|------------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------------------- |  | ---------- |  | ------- | ----- |  | ----------- |  | --------- | ------------- |  |  | - | 
|              |  |                                                                                                                                                                                                                 |  | Incorporated By Reference |  |            |  |        
|ExhibitNumber |  | Exhibit Description                                                                                                                                                                                             |  | Form                      |  | File No.   |  | Exhibit |       |  | Filing Date |  |           | FiledHerewith | 
|10.9         |  | Amendment No. 1 to Collaboration Agreement, dated June 17, 2003, between the Registrant and Biogen Idec MA Inc.                                                                                                 |  | S-1/A                     |  | 333-121646 |  |         | 10.27 |  |             |  | 1/27/2005 |               |  |  |   | 
|10.10        |  | Amendment No. 2 to Collaboration Agreement, dated September 17, 2003, between the Registrant and Biogen Idec MA
Inc.                                                                                            |  | S-1/A                     |  | 333-121646 |  |         | 10.28 |  |             |  | 1/27/2005 |               |  |  |   | 
|10.11        |  | Collaboration Agreement, dated August 25, 2004, between the Registrant and Biogen Idec, Inc.                                                                                                                    |  | S-1/A                     |  | 333-121646 |  |         | 10.29 |  |             |  | 4/29/2005 |               |  |  |   | 
|10.12        |  | License Agreement, dated October 14, 2003, by and between the Registrant and Dainippon Sumitomo Pharma Co., Ltd. (formerly known
as Dainippon Pharmaceutical Co., Ltd.)                                         |  | S-1/A                     |  | 333-121646 |  |         | 10.36 |  |             |  | 4/29/2005 |               |  |  |   | 
|10.13         |  | Warrant, dated August 25, 2005, issued to Horizon Technology Funding Company II LLC                                                                                                                             |  | S-1/A                     |  | 333-121646 |  |         | 10.40 |  |             |  | 9/1/2005  |               |  |  |   | 
|10.14         |  | Warrant, dated August 25, 2005, issued to Horizon Technology Funding Company III LLC                                                                                                                            |  | S-1/A                     |  | 333-121646 |  |         | 10.41 |  |             |  | 9/1/2005  |               |  |  |   | 
|10.15         |  | Warrant, dated August 25, 2005, issued to Oxford Finance Corporation                                                                                                                                            |  | S-1/A                     |  | 333-121646 |  |         | 10.42 |  |             |  | 9/1/2005  |               |  |  |   | 
|10.16         |  | Warrant, dated September 9, 2005, issued to General Electric Capital Corporation                                                                                                                                |  |                           |  |            |  |         |       |  |             |  |           |               |  |  | X | 
|10.17*        |  | Amended and Restated 2006 Employment Commencement Incentive Plan                                                                                                                                                |  | 10-K/A                    |  | 000-51531  |  |         | 10.32 |  |             |  | 4/30/2009 |               |  |  |   | 
|10.18         |  | Common Stock and Warrant Purchase Agreement, dated as of March 17, 2006, among the Registrant and the investors listed on the
signature pages thereto                                                           |  | 8-K                       |  | 000-51531  |  |         | 10.44 |  |             |  | 3/22/2006 |               |  |  |   | 
|10.19         |  | Registration Rights Agreement, dated as of March 17, 2006, among the Registrant and the investors listed on the signature pages
thereto                                                                         |  | 8-K                       |  | 000-51531  |  |         | 10.45 |  |             |  | 3/22/2006 |               |  |  |   | 
|10.20         |  | Form of Warrant                                                                                                                                                                                                 |  | 8-K                       |  | 000-51531  |  |         | 10.46 |  |             |  | 3/22/2006 |               |  |  |   | 
|10.21        |  | Sublease, dated December 22, 2006, by and between the Registrant and Oncology Therapeutics Network Joint Venture, L.P., for
office space located at 395 Oyster Point Boulevard, South San Francisco, California |  | 10-K                      |  | 000-51531  |  |         | 10.47 |  |             |  | 3/17/2008 |               |  |  |   | 
|10.22*        |  | Consulting Agreement, dated August 17, 2006, by and between the Registrant and Homer L. Pearce, Ph. D.                                                                                                          |  | 10-Q                      |  | 000-51531  |  |         | 10.49 |  |             |  | 5/9/2007  |               |  |  |   | 
|10.23*        |  | Consulting Agreement, dated September 2, 2006, by and between the Registrant and David C. Stump, M. D.                                                                                                          |  | 10-Q                      |  | 000-51531  |  |         | 10.50 |  |             |  | 5/9/2007  |               |  |  |   | 
|10.24*        |  | Forms of Stock Option Grant Notice and Stock Option Agreement under the 2005 Equity Incentive Award Plan                                                                                                        |  | 8-K                       |  | 000-51531  |  |         | 10.52 |  |             |  | 9/19/2007 |               |  |  |   | 



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|              |  |                                                                                                                                                          |  |                           |  |           |  |         |             |  |             |  |            |               |  |  |  | 
|------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------------------- |  | --------- |  | ------- | ----------- |  | ----------- |  | ---------- | ------------- |  |  |  | 
|              |  |                                                                                                                                                          |  | Incorporated By Reference |  |           |  |        
|ExhibitNumber |  | Exhibit Description                                                                                                                                      |  | Form                      |  | File No.  |  | Exhibit |             |  | Filing Date |  |            | FiledHerewith | 
|10.25*        |  | Amended and Restated Executive Severance Benefits Agreement, dated December 23, 2008, by and between the Registrant and Steven B.
Ketchum, Ph.D.         |  | 10-K                      |  | 000-51531 |  |         | 10.43       |  |             |  | 4/3/2009   |               |  |  |  | 
|10.26*        |  | Second Amended and Restated Executive Severance Benefits Agreement, dated December 24, 2008, by and between Registrant and Daniel
N. Swisher, Jr.        |  | 10-K                      |  | 000-51531 |  |         | 10.44       |  |             |  | 4/3/2009   |               |  |  |  | 
|10.27*        |  | Second Amended and Restated Executive Severance Benefits Agreement, dated December 24, 2008, by and between Registrant and Eric
H. Bjerkholt             |  | 10-K                      |  | 000-51531 |  |         | 10.45       |  |             |  | 4/3/2009   |               |  |  |  | 
|10.28*        |  | Second Amended and Restated Executive Severance Benefits Agreement, dated December 23, 2008, by and between Registrant and James
W. Young, Ph.D.         |  | 10-K                      |  | 000-51531 |  |         | 10.46       |  |             |  | 4/3/2009   |               |  |  |  | 
|10.29*        |  | Forms of Stock Option Grant Notice and Stock Option Agreement for Automatic Grants to Outside Directors under the 2005 Equity
Incentive Award Plan       |  | 10-Q                      |  | 000-51531 |  |         | 10.69       |  |             |  | 11/7/2008  |               |  |  |  | 
|10.30         |  | Forms of Stock Option Grant Notice and Stock Option Agreement under the Amended and Restated 2006 Employment Commencement
Incentive Plan                 |  | 8-K                       |  | 000-51531 |  |         | 10.71       |  |             |  | 12/23/2008 |               |  |  |  | 
|10.31         |  | Intellectual Property Assignment and License Termination Agreement by and between the Registrant and SARcode Corporation, dated
March 6, 2009            |  | 8-K                       |  | 000-51531 |  |         | 10.72       |  |             |  | 3/10/2009  |               |  |  |  | 
|10.32         |  | Form of Amended and Restated Convertible Secured Promissory Notes issued by SARcode Corporation to the Registrant, dated March 6,
2009                   |  | 8-K                       |  | 000-51531 |  |         | 10.73       |  |             |  | 3/10/2009  |               |  |  |  | 
|10.33         |  | Summary of Non-Employee Director Cash Compensation Arrangements                                                                                          |  | 10-Q                      |  | 000-51531 |  |         | 10.2        |  |             |  | 8/13/2010  |               |  |  |  | 
|10.34         |  | Intellectual Property Assignment and License Agreement, dated March 6, 2009, by and between the Company and SARcode Corporation,
and related Exhibit 3.2 |  | 8-K                       |  | 000-51531 |  |         | 10.72,10.73 |  |             |  | 3/10/2009  |               |  |  |  | 
|10.35         |  | Securities Purchase Agreement, dated March 31, 2009, by and among the Registrant and the purchasers identified on the signature
pages thereto            |  | 8-K                       |  | 000-51531 |  |         | 10.1        |  |             |  | 4/3/2009   |               |  |  |  | 
|10.36         |  | Form of Warrant to purchase shares of Common Stock                                                                                                       |  | 8-K                       |  | 000-51531 |  |         | 10.2        |  |             |  | 4/3/2009   |               |  |  |  | 
|10.37*        |  | Sunesis Pharmaceuticals, Inc. Amended and Restated Change of Control Payment Plan                                                                        |  | 8-K                       |  | 000-51531 |  |         | 10.1        |  |             |  | 9/21/2010  |               |  |  |  | 
|10.38*        |  | Sunesis Pharmaceuticals, Inc. Amended and Restated 2009 Bonus Program                                                                                    |  | 8-K                       |  | 000-51531 |  |         | 10.2        |  |             |  | 4/2/2010   |               |  |  |  | 



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|              |  |                                                                                                                                                                                                                    |  |                           |  |           |  |         |       |  |             |  |           |               |  |  |   | 
|------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ |  | ------------------------- |  | --------- |  | ------- | ----- |  | ----------- |  | --------- | ------------- |  |  | - | 
|              |  |                                                                                                                                                                                                                    |  | Incorporated By Reference |  |           |  |        
|ExhibitNumber |  | Exhibit Description                                                                                                                                                                                                |  | Form                      |  | File No.  |  | Exhibit |       |  | Filing Date |  |           | FiledHerewith | 
|10.39         |  | Agreement Regarding Private Placement of Securities of Sunesis Pharmaceuticals, Inc., dated as of June 29, 2009, by and among the
Registrant and the investors identified on the signature pages thereto           |  | 8-K                       |  | 000-51531 |  |         | 10.1  |  |             |  | 7/2/2009  |               |  |  |   | 
|10.40*        |  | Medical benefits arrangement with James W. Young, Ph.D.                                                                                                                                                            |  | 10-Q                      |  | 000-51531 |  |         | 10.65 |  |             |  | 7/28/2009 |               |  |  |   | 
|10.41         |  | Second Agreement Regarding Private Placement of Securities of Sunesis Pharmaceuticals, Inc., dated as of October 27, 2009, by and
among the Registrant and the investors identified on the signature pages thereto |  | 8-K                       |  | 000-51531 |  |         | 10.66 |  |             |  | 11/2/2009 |               |  |  |   | 
|10.42         |  | Third Agreement Regarding Private Placement of Securities of Sunesis Pharmaceuticals, Inc., dated as of January 19, 2010, by and
among the Registrant and the investors identified on the signature pages thereto  |  | 8-K                       |  | 000-51531 |  |         | 10.67 |  |             |  | 1/21/2010 |               |  |  |   | 
|10.43         |  | Sales Agreement, dated January 20, 2010, between the Registrant and Cantor Fitzgerald & Co.                                                                                                                        |  | 8-K                       |  | 000-51531 |  |         | 10.67 |  |             |  | 1/21/2010 |               |  |  |   | 
|10.44         |  | Fourth Agreement Regarding Private Placement of Securities of Sunesis Pharmaceuticals, Inc., dated as of March 29, 2010, by and
among the Registrant and the investors identified on the signature pages thereto   |  | 8-K                       |  | 000-51531 |  |         | 10.1  |  |             |  | 4/2/2010  |               |  |  |   | 
|10.45         |  | Sales Agreement, dated April 29, 2010, between the Registrant and Cantor Fitzgerald & Co.                                                                                                                          |  | 8-K                       |  | 000-51531 |  |         | 10.1  |  |             |  | 4/29/2010 |               |  |  |   | 
|10.46*        |  | Sunesis Pharmaceuticals, Inc. 2010 Bonus Program                                                                                                                                                                   |  | 8-K                       |  | 000-51531 |  |         | 10.2  |  |             |  | 9/21/2010 |               |  |  |   | 
|10.47         |  | Underwriting Agreement, dated September 30, 2010, by and between the Registrant and Cowen and Company LLC                                                                                                          |  | 8-K                       |  | 000-51531 |  |         | 1.1   |  |             |  | 10/1/2010 |               |  |  |   | 
|10.48         |  | Form of Warrant to Purchase Common Stock of the Registrant                                                                                                                                                         |  | 8-K                       |  | 000-51531 |  |         | 4.1   |  |             |  | 10/1/2010 |               |  |  |   | 
|10.49         |  | Master Services Agreement, dated November 3, 2003, by and between the Registrant and AAI Developmental Services
Inc.                                                                                               |  |                           |  |           |  |         |       |  |             |  |           |               |  |  | X | 
|10.50         |  | First Amendment to Master Services Agreement, dated September 11, 2006, by and between the Registrant and AAIPharma
Inc.                                                                                           |  |                           |  |           |  |         |       |  |             |  |           |               |  |  | X | 
|10.51         |  | Second Amendment to Master Services Agreement, dated May 2, 2008, by and between the Registrant and AAIPharma
Inc.                                                                                                 |  |                           |  |           |  |         |       |  |             |  |           |               |  |  | X | 
|10.52         |  | Third Amendment to Master Services Agreement, dated November 3, 2009, by and between the Registrant and AAIPharma Services
Corp.                                                                                   |  |                           |  |           |  |         |       |  |             |  |           |               |  |  | X | 
|10.53         |  | Master Services Agreement, dated January 1, 2010, by and between the Registrant and Albany Molecular Research,
Inc.                                                                                                |  |                           |  |           |  |         |       |  |             |  |           |               |  |  | X | 



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|              |  |                                                                                                                             |  |                           |      |  |          |  |           |         |  |  |             |  |  |               |           |  |  |  |   | 
|------------- |  | --------------------------------------------------------------------------------------------------------------------------- |  | ------------------------- | ---- |  | -------- |  | --------- | ------- |  |  | ----------- |  |  | ------------- | --------- |  |  |  | - | 
|              |  |                                                                                                                             |  | Incorporated By Reference |      |  |          | 
|ExhibitNumber |  | Exhibit Description                                                                                                         |  | Form                      |      |  | File No. |  |           | Exhibit |  |  | Filing Date |  |  | FiledHerewith |          
|10.54         |  | Master Services Agreement, dated June 21, 2010, by and between the Registrant and Icon Clinical Research Limited            |  |                           |      |  |          |  |           |         |  |  |             |  |  |               |           |  |  |  | X | 
|21.1          |  | Subsidiaries of the Registrant                                                                                              |  |                           | 10-K |  |          |  | 000-51531 |         |  |  | 21.1        |  |  |               | 3/17/2008 |  |  |  |   | 
|23.1          |  | Consent of Independent Registered Public Accounting Firm                                                                    |  |                           |      |  |          |  |           |         |  |  |             |  |  |               |           |  |  |  | X | 
|31.1          |  | Certification of Chief Executive Officer pursuant to Rule 13a-14(a) or Rule 15d-14(a) of the Exchange Act                   |  |                           |      |  |          |  |           |         |  |  |             |  |  |               |           |  |  |  | X | 
|31.2          |  | Certification of Chief Financial Officer pursuant to Rule 13a-14(a) or Rule 15d-14(a) of the Exchange Act                   |  |                           |      |  |          |  |           |         |  |  |             |  |  |               |           |  |  |  | X | 
|32.1#         |  | Certification of Chief Executive Officer and Chief Financial Officer pursuant to 13a-14(b) or 15d-14(b) of the Exchange Act |  |                           |      |  |          |  |           |         |  |  |             |  |  |               |           |  |  |  | X | 



|* | Management contract, compensatory plan or arrangement.
|- | ------------------------------------------------------



| | Portions of the exhibit have been omitted pursuant to a request for confidential treatment. The omitted information has been filed separately with the Securities and
Exchange Commission.
|- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|# | In accordance with Item 601(b)(32)(ii) of Regulation S-K and SEC Release Nos. 33-8238 and 34-47986, Final Rule; Managements Reports on Internal Control over
Financial Reporting and Certification of Disclosure in Exchange Act Periodic Reports, the Certification furnished in Exhibit 32.1 hereto is deemed to accompany this Form 10-K and will not be filed for purposes of Section 18 of the Exchange Act.
Such certification will not be deemed incorporated by reference into any filing under the Securities Act or the Exchange Act, except to the extent that the registrant specifically incorporates it by reference.
|- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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