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                                                                   EXHIBIT 10.29

                     AMENDED EXECUTIVE EMPLOYMENT AGREEMENT

                                     PARTIES

         On September 1, 2000, PolyMedica Corporation, a Massachusetts
corporation having its principal place of business at 11 State Street, Woburn,
Massachusetts 01801 (the "Company") and Arthur A. Siciliano, Ph.D., an
individual with an address at 13 Salt Marsh Lane, Gloucester, MA 01930 (the
"Executive"), entered into an Executive Employment Agreement. The Company and
the Executive now both desire to replace that original agreement with this
Amended Executive Employment Agreement (this "Agreement") which will become
effective and supersede the prior agreement on April 1, 2001.

                               TERMS OF AGREEMENT

         In consideration of this Agreement and the employment and/or continued
employment of the Executive by the Company, the parties agree as follows:

         1. Employment. The Company hereby employs Executive, on a full-time
basis, to act as an executive of the Company and to perform such acts and duties
and furnish such services to the Company as the Company's Chief Executive
Officer or Board of Directors (the "Board") shall from time to time reasonably
direct. Executive hereby accepts said employment. Executive shall use his best
and most diligent efforts to promote the interests of the Company; shall
discharge his duties in a highly competent manner; and shall devote his full
business time and his best business judgment, skill and knowledge to the
performance of his duties and responsibilities hereunder. Executive shall report
directly to the Chief Executive Officer of the Company or such officer of the
Company as may be designated by the Chief Executive Officer or the Board.
Nothing contained herein shall preclude Executive from devoting incidental and
insubstantial amounts of time to activities other than the business of the
Company and which are not inconsistent with the best interests of the Company.

         2. Terms of Employment. The Company agrees to employ the Executive for
a twelve (12) month period commencing on April 1, 2001 (the "Employment
Period"). Notwithstanding the foregoing, both Executive and the Company shall
have the right to terminate the Executive's employment under this Agreement upon
thirty (30) days' written notice to the other party, subject to the Company's
obligation to pay severance benefits under certain circumstances as provided in
Section 3.6. If Executive shall remain in the employ of the Company beyond the
Employment Period, in the absence of any other express agreement between the
parties, this Agreement shall be deemed to continue on a month-to-month basis
(the "Extended Employment Period").

         3. Compensation and Benefits; Disability.

                  3.1. Salary. During Executive's employment, the Company shall
pay Executive an annualized base salary of $363,000 ("Base Salary") payable in
equal installments pursuant to the Company's customary payroll policies in force
at the time of payment (but in no event less frequently than monthly), less all
required and authorized payroll deductions and state and federal withholdings.
Executive's Base Salary may be adjusted from time to time in the sole discretion
of the Board or the Compensation Committee of the Board (the "Compensation
Committee") and shall be reviewed annually by the Compensation Committee.

                  3.2. Bonus Payment. During the Employment Period, Executive
may receive, in the sole discretion of the Compensation Committee, an annual
discretionary bonus payment in an amount, if any, to


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be determined by the Compensation Committee.

                  3.3. Executive Benefits. During the Employment Period,
Executive shall be entitled to participate in all benefit programs that the
Company establishes and makes available to its other executives and employees,
if any, in accordance with the relevant plan documents and requirements,
including but not limited to the following benefits:

                  (a) Health Insurance. Health and dental insurance; and

                  (b) Life Insurance. Life insurance on the life of Executive
with an Executive-directed beneficiary in the amount of 150% of Executive's Base
Salary.

                  (c) Stock Based Compensation. Executive will be eligible to
participate in the Company's Employee Stock Purchase Plan and to be considered
by the Compensation Committee for grants or awards of stock options or other
stock-based compensation under the Company's Stock Incentive Plan or similar
plans from time to time in effect. All such grants or awards shall be governed
by the governing Plan and shall be evidenced by the Company's then standard form
of stock option, restricted stock or other applicable agreement.

                  3.4. Vacation. Executive may take five weeks of paid vacation
during each year at such times as shall be consistent with the Company's
vacation policies and (in the Company's judgment) with the Company's vacation
schedule for executives and other employees.

                  3.5. Disability. If during the Employment Period Executive
shall become ill, disabled or otherwise incapacitated so as to be unable to
perform the essential functions of his position with or without reasonable
accommodation, as may be required by state or federal law, (a) for a period in
excess of ninety (90) consecutive days or (b) for more than one hundred-twenty
(120) days in any twelve (12) month period, then the Company shall have the
right to terminate this Agreement, in accordance with applicable laws, on thirty
(30) days' notice to Executive. A determination of disability shall be made by a
physician satisfactory to both the Executive and the Company, provided that if
the Executive and the Company do not agree on a physician, the Executive and the
Company shall each select a physician and these two together shall select a
third physician, whose determination shall be binding on all parties.

                  3.6. Severance Pay. If at any time during the term of this
Agreement (including any Extended Employment Period) there is a "Change of
Control" as defined in the Executive Retention Agreement dated September 1,
2000, and within six (6) months prior to that Change of Control the Company
terminates this Agreement without cause (i.e., other than pursuant to Section
3.5 or Section 4 hereof) and subject to the Executive's execution and
non-revocation of a severance agreement and release drafted by and satisfactory
to counsel for the Company, the Company shall continue to pay Executive at his
then current Base Salary for the remainder of the Employment Period or for
eighteen (18) months, whichever is longer (the "Severance Period"). Neither
party shall be entitled to any compensation or claim for good will or other loss
suffered by reason of termination of this Agreement.

                  3.7 Benefits During Severance Period. Except as otherwise
required by law, the Executive shall not be entitled to any employee benefits
provided under Section 3.3 after termination of Executive's employment whether
or not severance pay is being provided, except that (i) the Company shall
continue in full force and effect, at its expense, the life insurance provided
for in Section 3.3(b) for a period of eighteen (18) months after termination of
Executive's employment hereunder or until Executive becomes employed, whichever
first occurs, and (ii) during the Severance Period, the Company shall offer
continued health and dental insurance as required under the Consolidated Omnibus
Budget Reconciliation Act of 1985 ("COBRA") or other law and shall reimburse the
Executive for the full cost of that coverage. If Executive


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elects not to maintain health insurance pursuant to COBRA or other law, the
Company is under no obligation to reimburse Executive for his otherwise elected
coverage. Executive shall be obligated to give the Company prompt notice of his
subsequent employment and at that time, the Company's obligations pursuant to
this Section 3.7, if any, shall cease.

         4. Discharge for Cause. The Company may discharge Executive and
terminate his employment under this Agreement for cause without further
liability to the Company. As used in this Section 4, "cause" shall mean any or
all of the following:

                  (a) a good faith finding by the Company of failure of the
Executive to perform his assigned duties for the Company, including but not
limited to dishonesty, gross negligence, misconduct, theft or embezzlement from
the Company, the intentional provision of services to competitors of the
Company, or improper disclosure of proprietary information.

                  (b) indictment, conviction (or the entry of a pleading of
guilty or nolo contendere by Executive) of a fraud or felony or any criminal
offense involving dishonesty, breach of trust or moral turpitude during
Executive's employment;

                  (c) Executive's breach of any of the agreements originally
executed in connection with his original Employment Agreement dated September 1,
2000, as enumerated in Section 10.1.

         In the event the Company exercises its right to terminate Executive's
employment under this Section 4, Executive shall not be entitled to receive any
severance pay or other termination benefits.

         5. Termination Without Cause. The Company may terminate this Agreement
without cause without further liability to the Company except as set forth in
Section 3.6 and 3.7.

         6. Expenses. Pursuant to the Company's customary policies in force at
the time of payment, Executive shall be promptly reimbursed for business related
expenses.

         7. Agreement Not to Compete. Executive acknowledges and confirms his
Agreement Not to Compete and his Confidentiality and Proprietary Information
Agreement, each dated May 16, 1990, (or under any similar later agreements) with
the Company (the "Additional Agreements"), which shall survive the termination
of this Agreement.

         8. Arbitration. The Executive agrees that any dispute or controversy
arising out of or relating in any way to the Executive's employment with and/or
termination from the Company (including, but not limited to, all claims, demands
or actions under any federal, state or local statute or regulation regarding
employment discrimination, and/or all claims, demands or actions concerning the
interpretation, construction, performance or breach of this Employment
Agreement) shall be settled by arbitration held in Boston, Massachusetts in
accordance with the Rules of the American Arbitration Association, before an
arbitrator who shall have experience in the area of the matter in dispute. Each
party shall bear its own costs and attorneys' fees in connection with any
arbitration pursuant to this paragraph. Provided, however, that this paragraph
shall not apply to any dispute or controversy arising out of or relating in any
way to the interpretation, construction, performance or breach of the
Non-Solicitation and Non-Competition Agreement contained at Paragraph 4 herein
or the Confidential Information and Non-Disclosure Agreement attached hereto as
Exhibit A, and no such dispute or controversy shall be deemed to be arbitrable
in the absence of the Corporation's written agreement.

         9. Notices. Any notice or communication given by any party hereto to
the other party or parties shall be in writing and personally delivered or
mailed by certified mail, return receipt requested, postage


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prepaid, to the addresses provided above. All notices shall be deemed given when
actually received. Any person entitled to receive notice (or a copy thereof) may
designate in writing, by notice to the others, another address to which notices
to such person shall thereafter be sent.

         10. Miscellaneous.

                  10.1. Entire Agreement. This Agreement contains the entire
understanding of the parties in respect of its subject matter and supersedes all
prior agreements and understandings between the parties with respect to such
subject matter; provided that nothing in this Agreement shall affect Executive's
or the Company's obligations under the Additional Agreements.

                  10.2 Amendment; Waiver. This Agreement may not be amended,
supplemented, cancelled or discharged, except by written instrument executed by
the party affected thereby. No failure to exercise, and no delay in exercising,
any right, power or privilege hereunder shall operate as a waiver thereof. No
waiver of any breach of any provision of this Agreement shall be deemed to be a
waiver of any preceding or succeeding breach of the same or any other provision.

                  10.3. Binding Effect; Assignment. The rights and obligations
of this Agreement shall bind and inure to the benefit of any successor of the
Company by reorganization, merger or consolidation, or any assignee of all or
substantially all of the Company's business and properties. Executive's rights
or obligations under this Agreement may not be assigned by Executive; except
that Executive's right to compensation to the earlier of date of death or
termination of actual employment shall pass to Executive's executor or
administrator.

                  10.4. Headings. The headings contained in this Agreement are
for reference purposes only and shall not affect the meaning or interpretation
of this Agreement.

                  10.5. Applicable Law. This Agreement shall be interpreted and
construed by the laws of the Commonwealth of Massachusetts, without regard to
conflict of laws provisions. Executive hereby irrevocably submits and
acknowledges and recognizes the jurisdiction of the courts of the Commonwealth
of Massachusetts, or if appropriate, a federal court located in Massachusetts
(which courts, for purposes of this Agreement, are the only courts of competent
jurisdiction), over any suit, action or other proceeding arising out of, under
or in connection with this letter agreement or the subject matter hereof.

                  10.6 Other Agreements. Executive hereby represents that he is
not bound by the terms of any agreement with any previous employer or other
party to refrain from using or disclosing any trade secret or confidential or
proprietary information in the course of his employment with the Company, or to
refrain from competing, directly or indirectly, with the business of such
previous employer or any other party. Executive further represents that his
performance of all the terms of this Agreement and as an employee of the Company
does not and will not breach any agreement to keep in confidence proprietary
information, knowledge or data acquired by him in confidence or trust prior to
his employment with the Company.

                  10.7. Further Assurances. Each of the parties agrees to
execute, acknowledge, deliver and perform, or cause to be executed,
acknowledged, delivered or performed, at any time, or from time to time, as the
case may be, all such further acts, deeds, assignments, transfers, conveyances,
powers of attorney and assurances as may be necessary or proper to carry out the
provisions or intent of this Agreement.

                  10.8. Severability. If any one or more of the terms,
provisions, covenants or restrictions of this Agreement shall be determined by a
court of competent jurisdiction to be invalid, void or unenforceable, the
remainder of the terms, provisions, covenants and restrictions of this Agreement
shall remain in full force and effect and shall in no way be affected, impaired
or invalidated. If, moreover, any one or more of the


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provisions contained in this Agreement shall for any reason be determined by a
court of competent jurisdiction to be excessively broad as to duration,
geographical scope, activity or subject, it shall be construed by limiting or
reducing it so as to be enforceable to the extent compatible with then
applicable law.

                                    EXECUTION

         The parties executed this Agreement as a sealed instrument as of the
date first above written, whereupon it becomes binding in accordance with its
terms.

                                         POLYMEDICA CORPORATION


                                         /s/ Steven J. Lee
                                         -----------------
                                         By:     Steven J. Lee
                                         Title:  Chairman and CEO

AGREED TO AND ACCEPTED:



/s/ Arthur A. Siciliano
-----------------------
Arthur A. Siciliano