### 1 

# Supplemental Information on **E**

**- FAST CEM Outputs (Degreaser**  **Use)**

FIRST IS A DESCRIPTION OF THE ASSUMPTIONS, THEN THE MODEL OUTPUT FOLLOWS

(NOTE THAT FULL CITATIONS FOR ALL REFERENCES CITED CAN BE FOUND IN THE REFERENCE SECTION OF THE RISK ASSESSMENT)

Exposure Scenario for Aerosol Solvent Degreaser

1. Description of the product from manufacturer’s product technical data sheet and

13

- Sep

- 2011 Material Safety Data Sheet (s ee supplemental document titled “Supplemental Product Information for the TSCA Workpla n Chemical Risk Assessment of TCE (External Review Draft).pdf” for more details):

• Removes oil and grease stains, ink, and fresh paint easily.

• Very effective for cleaning oily and greasy parts while servicing, repairing, or replacing them.

• Can be used on m etal parts prior to painting or soldering.

• Will not short motors, generators, compressors, condensers, or other electrical equipment.

• Removes unwanted ink spots, dirt, grease, oil, fresh paint, and other troublesome stains fast. Also effective on tar, adh esive marks, crayon marks, and lipstick.

• Use this product on metal parts prior to painting or soldering, painted surfaces, insulation, rubber

, and fabrics. Electric motors and generators may be cleaned while in use under properly ventilated conditions. A lso for use on sewing machines, cutting tools, switches, control panels, and thermostats.

2. Assumptions for E

- FAST/CEM model runs:

• Start with the E

- FAST/CEM default assumptions for Aerosol Paint, and adjust the assumptions for frequency of use, exposure du ration (chronic), mass of product per event, and duration of event to represent automotive hobbyist use of aerosol solvent degreaser. Retain other assumptions for “Product Sprayed on Surface

– Constant Rate and Incremental Models”: assume that one percen t of the sprayed product is aerosolized and is therefore immediately available for uptake by inhalation; assume that the remainder of the product contacts the target surface, and subsequently volatilizes at a rate that depends upon the chemical’s molecular weight and vapor pressure. [The aerosolized portion is treated using a constant emission rate model. The remaining (non

- aerosolized) mass is treated by combining a constant application rate with an exponentially declining rate for each instantaneously a pplied segment.]

### 2 

### • User is an automotive hobbyist who uses the aerosol solvent degreaser indoors, at home, twice a month (24 events per year) to clean automotive parts. The scenario does not include uses in the garage, on the driveway, etc.

• Hobbyist uses one can of aerosol solvent degreaser every year. Hobbyist therefore uses 20 ounces of aerosol solvent degreaser per year, 20/24 = 0.83 ounces of aerosol solvent degreaser per use, 0.83 ounces x 28.349523 g/ounce = 24 g aerosol solvent degreaser/use.

• An ac tual formulation of aerosol solvent degreaser contains >90 percent TCE. For

E

- FAST/CEM, assume a weight fraction of 0.9.

• The hobbyist is an adult who uses the aerosol solvent degreaser for 57 years as an adult (ages 21 to 78) or the hobbyist is a teenager or young adult who uses the aerosol solvent degreaser for 5 years (ages 16 to 20).

• Non

- user residents of the home can be of any age.

• The E

- FAST/CEM runs estimate the active exposure of the user (hobbyist) and the passive exposure of non

- users living in a home where the aerosol solvent degreaser is used. Age groups are: less than age 1; ages 1 to 2; ages 3 to 5; ages 6 to 10; ages

11 to 15; ages 16 to 20; and ages 21 to 78.

• E

- FAST/CEM scenarios for children do not permit them to be present in the room of use during product use. Estimated exposures therefore represent their passive exposures while they are elsewhere in the home.

• Duration of event is one hour.

• Molecular weight of TCE is 131.39.

• Vapor pressure of TCE is 73.46 torr at 25 ° C.



# ---------------- ---------------------------------------------------

### 3 

# E

- FAST/CEM Input and Output Summaries for Aerosol Solvent Degreaser

CEM Inputs ID Number: 1 degreaser user 21

- 78
Product: aerosol solvent degreaser Chemical Name: TCE

Scenario: User Defined Population: ages 21

- 78
Molecular Weight (g/mole): 131.4 Vapor Pressure (torr): 73.46
Consumer Product Weight Fraction

- Central Tendency (unitless): 0.9 Consumer Product Weight Fraction

- High

- End (unitless): 0.9

Inhalation Inputs
Frequency of Use (chronic) (events/yr): 24 Exposure Duration (chronic) (years): 57

Frequency of Use (acute) (events/day): 1 Exposure Duration (acute) (days): 1

Mass of Product Used per Event

- Central Tendency (g): 24 Mass of Product Used per Event

- High

- End (g): 24

Inhalation Rate During Use (m 3 /hr): 0.74 Duration of Event

- Central Tendency (hours/event): 1

Inhalation Rate After Use (m 3 /hr): 0.611 Duration of Event

- High

- End (hours/event): 1

Zone 1 Volume (m 3 ): 20 Whole House Volume (m 3 ): 369
Air Exchange Rate (air exchanges/hr): 0.45 Body Weight (kg): 80

Portion of Aerosol in Air (unitless): 0.01

Activity Patterns

User: 1 1 1 1 1 1 1 2 3 5 5 4 2 4 7 7 4 2 2 7 4 4 4 1

Non

- User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Hour: 0 6 12 18

Start Time: 9 Room of Use: 5. Utility Room

Dermal Inputs
There are no Dermal inputs for this scenario.
Averaging Time (chronic) (days): 2.85e+

04 Averaging time (acute) (days) : 1

Activity Patterns: 1 Bedroom; 2 Kitchen; 3 Bathroom; 4 Living Room; 5 Utility Room; 6 Car; 7 Out (outside the house)

### 4 CEM Inhalation Exposure Estimates ID Number: 1 degreaser user 21

- 78
Scenario: User Defined Population: ages 21

- 78 Exposure Duration (years) chronic: 57 Exposure Duration (days) acute: 1

Exposure Units Result AT (days)

Chronic Cancer

LADD pot (mg/kg

- day) 1.37e

- 01 2.85e+04

LADC pot (mg/m 3 ) 6.66e

- 01 2.85e+04

Acute

ADR pot (mg/kg

- day) 2.85e+00 1 Cp pot (mg/m 3 ) 2.59e+02 NA

LADD

- Lifetime Average Daily Dose (mg/kg

day) LADC

- Lifetime Average Daily Concentration (mg/m 3 )

ADR

- Acute Dose Rate (mg/kg

- day) Cp

- Peak Concentration (mg/m 3 )

Note: 78 years = 2.85e+04 days ; pot

- potential dose Note: The potential peak concentration (Cp pot ) is defined as the highest instantaneous air concentration that is calculated by the model during any 10

- second time step, and should not be interpreted as a daily maximum

concentration.

Note: The general Agency guidance for assessing short

- term, infrequent events (for most chemicals, an exposure of less than 24 hours that occurs no more frequently than monthly) is to treat such events as independent, acute exposures rather than as chronic expo sure ( US EPA, 1998a )

.

### 5 CEM Inputs ID Number: 2 degreaser non

- user 21

- 78 Product: aerosol solvent degreaser Chemical Name: TCE

Scenario: User Defined Population: ages 21

- 78 Molecular Weight (g/mole): 131.4 Vapor Pressure (torr): 73.46 Consumer Product Weight Fraction

- Central Tendency (unitless): 0.9 Consumer Product Weight Fraction

- High

- End (unitless): 0.9

Inhalation Inputs Frequency of Use (chronic) (events/yr): 24 Exposure Duration (chronic) (years): 57

Frequency of Use (acute) (events/day): 1 Exposure Duration (acute) (days): 1

Mass of Product Used per Event

- Central Tendency (g): 24 Mass of Product Used per Event

- High

- End (g): 24

Inhalation Rate During Use (m 3 /hr): 0.611 Duration of Event

- Central Tendency (hours/event): 1

Inhalation Rate After Use (m 3 /hr): 0.611 Duration of Event

- High

- End (hours/event): 1

Zone 1 Volume (m 3 ): 20 Whole House Volume (m 3 ): 369 Air Exchange Rate (air exchanges/hr): 0.45 Body Weight (kg): 80

Portion of Aerosol in Air (unitless): 0.01 Activity Patterns

User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Non

- User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Hour: 0 6 12 18

Start Time: 9 Room of Use: 5. Utility Room Dermal Inputs There are no Dermal inputs for this scenario. Averaging Time (chronic) (days): 2.85e+

04 Averaging time (acute) (days) : 1

Activity Patterns: 1 Bedroom; 2 Kitchen; 3 Bathroom; 4 Living Room; 5 Utility Room; 6 Car; 7 Out (outside the house)

### 6 CEM Inhalation Exposure Estimates ID Number: 2 degreaser non

- user 21

- 78
Scenario: User Defined Population: ages 21

- 78 Exposure Duration (years) chronic: 57 Exposure Duration (days) acute: 1

Exposure Units Result AT (days)

Chronic Cancer

LADD pot (mg/kg

- day) 3.92e

- 02 2.85e+04

LADC pot (mg/m 3 ) 2.13e

- 01 2.85e+04

Acute

ADR pot (mg/kg

- day) 8.16e

- 01 1 Cp pot (mg/m 3 ) 3.84e+01 NA

LADD

- Lifetime Average Daily Dose (mg/kg

- day) LADC

- Lifetime Average Daily Concentration (mg/m 3 )

ADR

- Acute Dose Rate (mg/kg

- day) Cp

- Peak Concentration (mg/m 3 )

Note: 78 years = 2.85e+04 days ; pot

- potential dose Note: The potential peak concentration (Cp pot ) is defined as the highest instantaneous air concentration that is calculated by the model during any 10

- second time step, and should not be interpreted as a daily maximum

concentration.

Note: The general Agency guidance for assessing short

- term, infrequent events (for most chemicals, an exposure of less than 24 hours that occurs no more frequently than monthly) is to treat such events as independent, acute exposures rather than as chronic expos ure ( US EPA, 1998a )

.

### 7 CEM Inputs ID Number: 3 degreaser user 16

- 20 Product: aerosol solvent degreaser Chemical Name: TCE

Scenario: User Defined Population: ages 16

- 20 Molecular Weight (g/mole): 131.4 Vapor Pressure (torr): 73.46 Consumer Product Weight Fraction

- Central Tendency (unitless): 0.9 Consumer Product Weight Fraction

- High

- End (unitless): 0.9

Inhalation Inputs Frequency of Use (chronic) (events/yr): 24 Exposure Duration (chronic) (years): 5

Frequency of Use (acute) (events/day): 1 Exposure Duration (acute) (days): 1

Mass of Product Used per Event

- Central Tendency (g): 24 Mass of Product Used per Event

- High

- End (g): 24

Inhalation Rate During Use (m 3 /hr): 0.72 Duration of Event

- Central Tendency (hours/event): 1

Inhalation Rate After Use (m 3 /hr): 0.679 Duration of Event

- High

- End (hours/event): 1

Zone 1 Volume (m 3 ): 20 Whole House Volume (m 3 ): 369 Air Exchange Rate (air exchanges/hr): 0.45 Body Weight (kg): 71.6

Portion of Aerosol in Air (unitless): 0.01 Activity Patterns

User: 1 1 1 1 1 1 1 1 3 5 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Non

- User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Hour: 0 6 12 18

Start Time: 9 Room of Use: 5. Utility Room Dermal Inputs There are no Dermal inputs for this scenario. Averaging Time (chronic) (days): 2.85e+

04 Averaging time (acute) (days) : 1

Activity Patterns: 1 Bedroom; 2 Kitchen; 3 Bathroom; 4 Living Room; 5 Utility Room; 6 Car; 7 Out (outside the house)

### 8 CEM Inhalation Exposure Estimates ID Number: 3 degreaser user 16

- 20
Scenario: User Defined Population: ages 16

- 20 Exposure Duration (years) chronic: 5 Exposure Duration (days) acute: 1

Exposure Units Result AT (days)

Chronic Cancer

LADD pot (mg/kg

- day) 1.18e

- 02 2.85e+04

LADC pot (mg/m 3 ) 5.00e

- 02 2.85e+04

Acute

ADR pot (mg/kg

- day) 2.81e+00 1 Cp pot (mg/m 3 ) 2.59e+02 NA

LADD

- Lifetime Average Daily Dose (mg/kg

- day) LADC

- Lifetime Average Daily Concentration (mg/m 3 )

ADR

- Acute Dose Rate (mg/kg

- day) Cp

- Peak Concentration (mg/m 3 )

Note: 78 years = 2.85e+04 days ; pot

- potential dose Note: The potential peak concentration (Cp pot ) is defined as the highest instantaneous air concentration that is calculated by the model during any 10

- second time step, and should not be interpreted as a daily maximum

concentration. Note: The general Agency guidance for assessing short

- term, infrequent events (for most chemicals, an exposure of less than 24 hours that occurs no more frequently than monthly) is to treat such events as independent, acute exposures rather than as chronic exposure ( US EPA, 1998a )

.

### 9 CEM Inputs ID Number: 4 degreaser non

- user 16

- 20 Product: aerosol solvent degreaser Chemical Name: TCE

Scenario: User Defined Population: ages 16

- 20 Molecular Weight (g/mole): 131.4 Vapor Pressure (torr): 73.46

Consumer Product Weight Fraction

- Central Tendency (unitless): 0.9 Consumer Product Weight Fraction

- High

- End (unitless): 0.9

Inhalation Inputs Frequency of Use (chronic) (events/yr): 24 Exposure Duration (chronic) (years): 5

Frequency of Use (acute) (events/day): 1 Exposure Duration (acute) (days): 1

Mass of Product Used per Event

- Central Tendency (g): 24 Mass of Product Used per Event

- High

- End (g): 24

Inhalation Rate During Use (m 3 /hr): 0.679 Duration of Event

- Central Tendency (hours/event): 1

Inhalation Rate After Use (m 3 /hr): 0.679 Duration of Event

- High

- End (hours/event): 1

Zone 1 Volume (m 3 ): 20 Whole House Volume (m 3 ): 369 Air Exchange Rate (air exchanges/hr): 0.45 Body Weight (kg): 71.6

Portion of Aerosol in Air ( unitless): 0.01 Activity Patterns

User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Non

- User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Hour: 0 6 12 18

Start Time: 9 Room of Use: 5. Utility Room Dermal Inputs There are no Dermal inputs for this scenario. Averaging Time (chronic) (days): 2.85e+

04 Averaging time (acute) (days) : 1

Activity Patterns: 1 Bedroom; 2 Kitchen; 3 Bathroom; 4 Living Room; 5 Utility Room; 6 Car; 7 Out (outside the house)

### 10 CEM Inhalation Exposure Estimates ID Number: 4 degreaser non

- user 16

- 20
Scenario: User Defined Population: ages 16

- 20 Exposure Duration (years) chronic: 5 Exposure Duration (days) acute: 1

Exposure Units Result AT (days)

Chronic Cancer

LADD pot (mg/kg

- day) 4.27e

- 03 2.85e+04

LADC pot (mg/m 3 ) 1.87e

- 02 2.85e+04

Acute

ADR pot (mg/kg

- day) 1.01e+00 1 Cp pot (mg/m 3 ) 3.84e+01 NA

LADD

- Lifetime Average Daily Dose (mg/kg

- day) LADC

- Lifetime Average Daily Concentration (mg/m 3 )

ADR

- Acute Dose Rate (mg/kg

- day) Cp

- Peak Concentration (mg/m 3 )

Note: 78 years = 2.85e+04 days ; pot

- potential dose Note: The potential peak concentration (Cp pot ) is defined as the highest instantaneous air concentration that is calculated by the model during any 10

- second time step, and should not be interpreted as a daily maximum

concentration. Note: The general Agency guidance for assessing short

- term, infreque nt events (for most chemicals, an exposure of less than 24 hours that occurs no more frequently than monthly) is to treat such events as independent, acute exposures rather than as chronic exposure ( US EPA, 1998a )

.

### 11 CEM Inputs ID Number: 5 degreaser non

- user 11

- 15 Product: aerosol solvent degreaser Chemical Name: TCE

Scenario: User Defined Population: ages 11

- 15 Molecular Weight (g/mole): 131.4 Vapor Pressure (torr): 73.46 Consumer Product Weight Fraction

- Central Tendency (unitless): 0.9 Consumer Product Weight Fraction

- High

- End (unitless): 0.9

Inhalation Inputs Frequency of Use (chronic) (events/yr): 24 Exposure Duration (chronic) (years): 5

Frequency of Use (acute) (events/day): 1 Exposure Duration (acute) (days): 1

Mass of Product Used per Event

- Central Tendency (g): 24 Mass of Product Used per Event

- High

- End (g): 24

Inhalation Rate During Use (m 3 /hr): 0.633 Duration of Event

- Central Tendency (hours/event): 1

Inhalation Rate After Use (m 3 /hr): 0.633 Duration of Event

- High

- End (hours/event): 1

Zone 1 Volume (m 3 ): 20 Whole House Volume (m 3 ): 369 Air Exchange Rate (air exchanges/hr): 0.45 Body Weight (kg): 56.8

Portion of Aerosol in Air (unitless): 0.01 Activity Patterns

User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Non

- User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

0 Hour: 0 6 12 18

Start Time: 9 Room of Use: 5. Utility Room Dermal Inputs There are no Dermal inputs for this scenario. Averaging Time (chronic) (days): 2.85e+

04 Averaging time (acute) (days) : 1

Activity Patterns: 1 Bedroom; 2 Kitchen; 3 Bathroom; 4 Living Room; 5 Utility Room; 6 Car; 7 Out (outside the house)

### 12 CEM Inhalation Exposure Estimates ID Number: 5 degreaser non

- user 11

- 15
Scenario: User Defined Population: ages 11

- 15 Exposure Duration (years) chronic: 5 Exposure Duration (days) acute: 1

Exposure Units Result AT (days)

Chronic Cancer

LADD pot (mg/kg

- day) 5.01e

- 03 2.85e+04

LADC pot (mg/m 3 ) 1.87e

- 02 2.85e+04

Acute

ADR pot (mg/kg

- day) 1.19e+00 1 Cp pot (mg/m 3 ) 3.84e+01 NA

LADD

- Lifetime Average Daily Dose (mg/kg

- day) LADC

- Lifetime Average Daily Concentration (mg/m 3 )

ADR

- Acute Dose Rate (mg/kg

- day) Cp

- Peak Concentration (mg/m 3 )

Note: 78 years = 2.85e+04 days ; pot

- potential dose Note: The potential peak concentration (Cp pot ) is defined as the highest instantaneous air concentration that is calculated by the model during any 10

- second time step, and should not be interpreted as a daily maximum

concentration. Note: The general Agency guidance for assessing short

- term, infrequent events (for most chemicals, an exposure of less than 24 hours that occurs no more frequently than monthly) is to treat such events as independent, acute exposures rather than as chronic exposure ( US EPA, 1998a )

.

### 13 CEM Inputs ID Number: 6 degreaser non

- user 6

- 10 Product: aerosol solvent degreaser Chemical Name: TCE

Scenario: User Defined Population: ages 6

- 10 Molecular Weight (g/mole): 131.4 Vapor Pressure (torr): 73.46
Consumer Product Weight Fraction

- Central Tendency (unitless): 0.9 Consumer Product Weight Fraction

- High

- End (unitless): 0.9

Inhalation Inputs Frequency of Use (chronic) (events/yr): 24 Exposure Duration (chronic) (years): 5

Frequency of Use (acute) (events/day): 1 Exposure Duration (acute) (days): 1

Mass of Product Used per Event

- Central Tendency (g): 24 Mass of Product Used per Event

- High

- End (g): 24

Inhalation Rate During Use (m 3 /hr): 0.5 Duration of Event

- Central Tendency (hours/event): 1

Inhalation Rate After Use (m 3 /hr): 0.5 Duration of Event

- High

- End (hours/event): 1

Zone 1 Volume (m 3 ): 20 Whole House Volume (m 3 ): 369 Air Exchange Rate (air exchanges/hr): 0.45 Body Weight (kg): 31.8

Portion of Aerosol in Air (unitless): 0.01 Activity Patterns

User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Non

- User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Hour: 0 6 12 18

Start Time: 9 Room of Use: 5. Utility Room Dermal Inputs There are no Dermal inputs for this scenario. Averaging Time (chronic) (days): 2.85e+

04 Averaging time (acute) (days) : 1

Activity Patterns: 1 Bedroom; 2 Kitchen; 3 Bathroom; 4 Living Room; 5 Utility Room; 6 Car; 7 Out (outside the house)

### 14 CEM Inhalation Exposure Estimates ID Number: 6 degreaser non

- user 6

- 10
Scenario: User Defined Population: ages 6

- 10 Exposure Duration (years) chronic: 5 Exposure Duration (days) acute: 1

Exposure Units Result AT (days)

Chronic Cancer

LADD pot (mg/kg

- day) 7.07e

- 03 2.85e+04

LADC pot (mg/m 3 ) 1.87e

- 02 2.85e+04

Acute

ADR pot (mg/kg

- day) 1.68e+00 1 Cp pot (mg/m 3 ) 3.84e+01 NA

LADD

- Lifetime Average Daily Dose (mg/kg

- day) LADC

- Lifetime Average Daily Concentration (mg/m 3 )

ADR

- Acute Dose Rate (mg/kg

- day) Cp

- Peak Concentration (mg/m 3 )

Note: 78 years = 2.85e+04 days ; pot

- potential dose Note: The potential peak concentration (Cp pot ) is defined as the highest instantaneous air concentration that is calculated by the model during any 10

- second time step, and should not be interpreted as a daily maximum

concentration. Note: The general Agency guidance for assessing short

- term, infrequent events (for most chemical s, an exposure of less than 24 hours that occurs no more frequently than monthly) is to treat such events as independent, acute exposures rather than as chronic exposure ( US EPA, 1998a )

.

### 15 CEM Inputs ID Number: 7 degreaser non

- user 3

- 5 Product: aerosol solvent degreaser Chemical Name: TCE

Scenario: User Defined Population: ages 3

- 5 Molecular Weight (g/mole): 131.4 Vapor Pressure (torr): 73.46 Consumer Product Weight Fraction

- Central Tendency (unitless): 0.9 Consumer Product Weight Fraction

- High

- End (unitless): 0.9

Inhalation Inputs Frequency of Use (chronic) (events/yr): 24 Exposure Duration (chronic) (years): 3

Frequency of Use (acute) (events/day): 1 Exposure Duration (acute) (days): 1

Mass of Product Used per Event

- Central Tendency (g): 24 Mass of Product Used per Event

- High

- End (g): 24

Inhalation Rate During Use (m 3 /hr): 0.421 Duration of Event

- Central Tendency (hours/event): 1

Inhalation Rate After Use (m 3 /hr): 0.421 Duration of Event

- High

- End (hours/event): 1

Zone 1 Volume (m 3 ): 20 Whole House Volume (m 3 ): 369 Air Exchange Rate (air exchanges/hr): 0.45 Body Weight (kg): 18.6

Portion of Aerosol in Air (unitless): 0.01 Activity Patterns

User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Non

- User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Hour: 0 6 12 18

Start Time: 9 Room of Use: 5. Utility Room Dermal Inputs

There are no Dermal inputs for this scenario. Averaging Time (chronic) (days): 2.85e+

04 Averaging time (acute) (days) : 1

Activity Patterns: 1 Bedroom; 2 Kitchen; 3 Bathroom; 4 Living Room; 5 Utility Room; 6 Car; 7 Out (outside the house)

### 16 CEM Inhalation Exposure Estimates ID Number: 7 degreaser non

- user 3

- 5
Scenario: User Defined Population: ages 3

- 5 Exposure Duration (years) chronic: 3 Exposure Duration (days) acute: 1

Exposure Units Result AT (days)

Chronic Cancer

LADD pot (mg/kg

- day) 6.11e

- 03 2.85e+04

LADC pot (mg/m 3 ) 1.12e

- 02 2.85e+04

Acute

ADR pot (mg/kg

- day) 2.42e+00 1 Cp pot (mg/m 3 ) 3.84e+01 NA

LADD

- Lifetime Average Daily Dose (mg/kg

- day) LADC

- Lifetime Average Daily Concentration (mg/m 3 )

ADR

- Acute Dose Rate (mg/kg

- day) Cp

- Peak Concentration (mg/m 3 )

Note: 78 years = 2.85e+04 days ; pot

- potential dose Note: The potential peak concentration (Cp pot ) is defined as the highest instantaneous air concentration that is calculated by the model during any 10

- second time step, and should not be interpreted as a daily maximum

concentration. Note: The general Agency guidance for assessing short

- term, infrequent events (for most chemicals, an exposure of less than 24 hours that occurs no more frequently than monthly) is to treat such events as independent, acute exposures rather than as chronic exposure ( US EPA, 1998a )

.

### 17 CEM Inputs ID Number: 8 degreaser n on

- user 1

- 2 Product: aerosol solvent degreaser Chemical Name: TCE

Scenario: User Defined Population: ages 1

- 2 Molecular Weight (g/mole): 131.4 Vapor Pressure (torr): 73.46 Consumer Product Weight Fraction

- Central Tendency (unitless): 0.9 Consumer Product Weight Fraction

- High

- End (unitless): 0.9

Inhalation Inputs Frequency of Use (chronic) (events/yr): 24 Exposure Duration (chronic) (years): 2

Frequency of Use (acute) (events/day): 1 Exposure Duration (acute) (days): 1

Mass of Product Used per Event

- Central Tendency (g): 24 Mass of Product Used per Event

- High

- End (g): 24

Inhalation Rate During Use (m 3 /hr): 0.35 Duration of Event

- Central Tendency (hours/event): 1

Inhalation Rate After Use (m 3 /hr): 0.35 Duration of Event

- High

- End (hours/event): 1

Zone 1 Volume (m 3 ): 20 Whole House Volume (m 3 ): 369 Air Exchange Rate (air exchanges/hr): 0.45 Body Weight (kg): 12.6

Portion of Aerosol in Air (unitless): 0.01 Activity Patterns

User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Non

- User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Hour: 0 6 12 18

Start Time: 9 Room of Use: 5. Utility Room Dermal Inputs There are no Dermal inputs for this scenario. Averaging Time (chronic) (days): 2.85e+

04 Averaging time (acute) (days) : 1

Activity Patterns: 1 Bedroom; 2 Kitchen; 3 Bathroom; 4 Living Room; 5 Utility Room; 6 Car; 7 Out (outside the house)

### 18 CEM Inhalation Exposure Estimates ID Number: 8 degreaser non

- user 1

- 2
Scenario: User Defined Population: ages 1

- 2 Exposure Duration (years) chronic: 2 Exposure Duration (days) acute: 1

Exposure Units Result AT (days)

Chronic Cancer

LADD pot (mg/kg

- day) 5.00e

- 03 2.85e+04

LADC pot (mg/m 3 ) 7.50e

- 03 2.85e+04

Acute

ADR pot (mg/kg

- day) 2.97e+00 1 Cp pot (mg/m 3 ) 3.84e+01 NA

LADD

- Lifetime Average Daily Dose (mg/kg

- day) LADC

- Lifetime Average Daily Concentration (mg/m 3 )

ADR

- Acute Dose Rate (mg/kg

- day) Cp

- Peak Concentration (mg/m 3 )

Note: 78 years = 2.85e+04 days ; pot

- potential dose Note: The potential peak concentration (Cp pot ) is defined as the highest instantaneous air concentration that is calculated by the model during any 10

- second time step, and should not be interpreted as a daily maximum

concentration. Note: The general Agency guidance for assessing short

- term, infrequent events (for most chemicals, an exposure of less than 24 hours that occurs no more frequently than monthly) is to treat such events as independent, acute exposures rather than as chronic exposure ( US EPA, 1998a )

.

### 19 CEM Inputs ID Number: 9 degreaser non

- user <1 Product: aerosol solvent degreaser Chemical Name: TCE

Scenario: User Defined Population: age <1 Molecular Weight (g/mole): 131.4 Vapor Pressure (torr): 73.46 Consumer Product Weight Fraction

- Central Tendency (unitless): 0.9 Consumer Product Weight Fraction

- High

- End (unitless): 0.9

Inhalation Inputs Frequency of Use (chronic) (events/yr): 24 Exposure Duration (chronic) (years): 1

Frequency of Use (acute) (events/day): 1 Exposure Duration (acute) (days): 1

Mass of Product Used per Event

- Central Tendency (g): 24 Mass of Product Used per Event

- High

- End (g): 24

Inhalation Rate During Use (m 3 /hr): 0.23 Duration of Event

- Central Tendency (hours/event): 1

Inhalation Rate After Use (m 3 /hr): 0.23 Duration of Event

- High

- End (hours/event): 1

Zone 1 Volume (m 3 ): 20 Whole House Volume (m 3 ): 369 Air Exchange Rate (air exchanges/hr): 0.45 Body Weight (kg): 7.8

Portion of Aerosol in Air (unitless): 0.01 Activity Patterns

User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Non

- User: 1 1 1 1 1 1 1 1 3 2 4 4 2 4 7 7 4 2 2 7 4 4 4 1

Hour: 0 6 12 18

Start Time: 9 Room of Use: 5. Utility Room Dermal Inputs There are no Dermal inputs for this scenario. Averaging Time (chronic) (days): 2.85e+

04 Averaging time (acute) (days) : 1

Activity Patterns: 1 Bedroom; 2 Kitchen; 3 Bathroom; 4 Living Room; 5 Utility Room; 6 Car; 7 Out (outside the house)

### 20 CEM Inhalation Exposure Estimates

ID Number: 9 degreaser non

- user <1

Scenario: User Defined Population: age <1
Exposure Duration (years) chronic: 1 Exposure Duration (days) acute: 1

Exposure Units Result AT (days)

Chronic Cancer

LADD pot (mg/kg

- day) 2.65e

- 03 2.85e+04

LADC pot (mg/m 3 ) 3.75e

- 03 2.85e+04

Acute

ADR pot (mg/kg

- day) 3.15e+0

0 1

Cp pot (mg/m 3 ) 3.84e+0

1 NA

LADD

- Lifetime Average Daily Dose (mg/kg

- day) LADC

- Lifetime Average Daily Concentration (mg/m 3 )

ADR

- Acute Dose Rate (mg/kg

- day) Cp

- Peak Concentration (mg/m 3 )

Note: 78 years = 2.85e+04 days ; pot

- potential dose Note: The potential peak concentration (Cp pot ) is defined as the highest instantaneous air concentration that is calculated by the model during any 10

- second time step, and should not be interpreted as a daily maximum

concentration. Note: The general Agency guidance for assessing short

- term, infrequent events (for most chemicals, an exposure of less than 24 hours that occurs no more frequently than monthly) is to treat such events as independent, acute exposures rather than as chronic exposure ( US EPA, 1998a )

.

### 21 Exposure Parameter Values Used in E

- FAST/CEM for TCE Modeling

. Exposure

Parameter Population Exposure Type Default
Value Source Comment

Body Weight (BW) Adult (≥21 years) All 80.0 kg US EP A (2011d ) Table 8

- 3 (page 8

- 12): Average of mean body weights for all adults (≥21 years),
male and female combined. Based on US

EPA a nalysis of NHANES 1999

- 2006 data

. Youth (16

- 20 years) All 71.6 kg US EPA (2011d ) Table 8

- 1 (page 8

- 2): Mean body weight for age class 16

- <21 years. See Table 8

- 3 (page 8

- 12) for sample sizes. Based on US EPA analysis of NHANES 1999

- 2006 data.
Youth (11

- 15 years) All 56.8 kg US EPA (2011d ) Table 8

- 1 (page 8

- 2): Mean body weight for age class 11

- <16 years. See Table 8

- 3 (page 8

- 12) for sa mple sizes. Based on US EPA analysis of NHANES 1999

- 2006 data.
Child (6

- 10 years) All 31.8 kg US EPA (2011d ) Table 8

- 1 (page 8

- 2): Me an body weight for age class 6

- <11 years. See Table 8

- 3 (page 8

- 12) for sample sizes. Based on US EPA analysis of NHANES 1999

- 2006 data.
Small child (3

- 5 years) All 18.6 kg US EPA (2011d ) Table 8

- 1 (page 8

- 2): Mean body weight for age class 3

- <6 years. See Table 8

- 3 (page 8

- 12) for sample sizes. Based on US EPA analysis of NHANES 1999

- 2006 data.
Infant (1

- 2 years) All 12.6 kg US EPA (2011d ) Table 8

- 1 (page 8

- 2): Average of mean body weights for age classes 1

- <2 and 2

- <3 years. See Table 8

- 3 (page 8

- 12) for sample sizes. Based on US EPA analysis of

NHANES 1999

- 2006 data.
Infant (<1 year) All 7.8 kg US EPA (2011d ) Table 8

- 1 (page 8

- 2): Weighted averag e of mean body weights for age classes 0

- <1, 1

- <3, 3

- <6, and 6

- <12 months. See Table 8

- 3 (page 8

- 12) for sample sizes. Based on US EPA analysis of NHANES 1999

- 2006 data.

### 22 Exposure Parameter Values Used in E

- FAST/CEM for TCE Modeling.

Exposure

Parameter Population Exposure Type Default
Value Source Comment

Inhalation

Rate (InhR) Adult (≥21 years) Chronic 14.7 m 3 

### /day US EP A (2011d ) For general population exposures,
Table 6

- 1 (page 6

- 3): Average of mean long

- term exposure values for inhalation (males and females combined) for age classes 21

- <31,

31

- <41

, 41

- <51

, 51

- <61, 61

- <71

, and 71

- <81years.

Adult (≥21 years) Acute 0.74

m 3 

### /hour US EPA (2011d ) For consumer exposures, Table 6

- 2 (page 6

- 4): Average of mean short

term exposure values for inhalation during li ght activity (males and females combined) for the age
classes 21

- <31, 31

- <41, 41

- <51, 51

- <61, 61

- <71, and 71

- <81 years. For
consumer scenarios: 0.74 m 3 

### /hour during product use (based on short

term exposure at light activity level ; Table 6

- 2, page 6

- 4) and

0.611 m 3 

### /hour after product use.

Youth (16

- 20 years) Acute 16.3 m 3 

### /day US EPA (2011d ) For general population exposures,
Table 6

- 1 (page 6

- 3): Mean long

term exposure value for inhalation (males and females combined) for age class 16

- <21 years. Children are typically considered to be non

users, however, for consumer exposures: 0.72 m 3 

### /hour during product use (based on short

- term exposure at light activity level ; Table 6

- 2, page 6

- 4) and 0.679

m 3 

### /hour after product use.

Youth (11

- 15 years) Acute 15.2 m 3 

### /day US EPA (2011d ) Fo r general population exposures:
Table 6

- 1 (page 6

- 3): Mean long

term exposure value for inhalation (males and females combined) for age class 11

- <16 years. Children are
considered to be non

- users: 0.633 m 3 

### /hour before and after product use.

### 23 Exposure Parameter Values Used in E

- FAST/CEM for TCE Modeling.

Exposure

Parameter Population Exposure Type Default
Value Source Comment

Child (6

- 10 years) Acute 12.0 m 3 

### /day US EPA (2011d ) For general population exposures:
Table 6

- 1 (page 6

- 3): Mean long

term exposure value for inhalation (males and females combined) for age class 6

- <11 years. Children are
considered to be non

- users: 0.500 m 3 

### /hour before and after product use.

Small child (3

- 5 years) Acute 10.1 m 3 

### /day US EPA (2011d ) For general population exposures:
Table 6

- 1 (page 6

- 3): Mean long

term exposure value for inhalation (males and females combined) for age class 3

- <6 years. Children are
considered to be non

- user s: 0.421 m 3 

### /hour before and after product use.

Infant (1

- 2 years) Acute 8.5 m 3 

### /day US EPA (2011d ) For general population exposures:
Tabl e 6

- 1 (page 6

- 3): Average of mean long

- term exposure values for inhalation (males and females combined) for age classes 1

- <2 and

2

- <3 years. Children are considered
to be non

- users: 0.35 m 3 

### /hour before and after product use.

Infant (<1 year) Acute 5.4 m 3 

### /day US EPA (2011d ) For general population exposures:
Table 6

- 1 (page 6

- 3): Mean long

term exposure values for inhalation (males and females combined) for the age class birth to <1 year.
Children are considered to be non

users: 0.23 m 3 

### /hour before and after product use.

Exposure Duration (ED) Adult (≥21 years) Chronic 57 years US EPA (2011d ) Adult lifetime exposure duration, based on life expectancy of 78 years (Table 18

- 1). Exposure from 21 to 78 years of age. Previously,

18 years was used as the initiation
of this durati on. For consumer

exposures

. Adult (≥21 years) Acute 1 day

_ Assumed 1

- day exposure for acute

scenarios.

### 24 Exposure Parameter Values Used in E

- FAST/CEM for TCE Modeling.

Exposure

Parameter Population Exposure Type Default
Value Source Comment

Youth (16

- 20 years) Acute 1 day

_ Assumed 1

- day exposure for acute

scenarios.

Youth (11

- 15 years) Acute 1 day

_ Assumed 1

- day exposure for acute

scenarios.

Child (6

- 10 years) Acute 1 day

_ Assumed 1

- day exposure for acute

scenarios.

Small child (3

- 5 years) Acute 1 day

_ Assumed 1

- day exposure for acute

scenarios.

Infant (1

- 2 years) Acute 1 day

_ Assumed 1

- day exposure for acute

scenarios.

Infant (<1 year) Acute 1 day

_ Assumed 1

- day exposure for acute

scenarios.

Carcinogenic Averaging Time (AT) Adult (≥21 years) Chronic 78 years US EPA (2011d ) Table 18

- 1 (page 18

- 1): Average of male and female life expectancy.
This recommended value is reflective of the average life expectancy of the general population. Data were collected in 2007 and published in 2010 ( Xu et al. , 2010 )

Acute Averaging Time (AT) All Acute 1 day

_ Assumed 1

- day exposure for acute

scenarios.