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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549



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Form 10-K/A

Amendment No. 1



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ANNUAL REPORT

PURSUANT TO SECTIONS 13 OR 15(d)

OF
THE SECURITIES EXCHANGE ACT OF 1934

(Mark One)

|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended: December 31, 2006



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from  to

Commission file number: 000-50676



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Icagen, Inc.

(Exact name of registrant as specified in its charter)



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|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                       |  | 56-1785001                          
|(State or other jurisdiction of incorporation or organization) |  | (I.R.S. Employer Identification No.)

4222 Emperor Boulevard, Suite 350

Durham, North Carolina 27703

(Address of principal executive offices,
including zip code)

Registrants telephone number, including area code: (919) 941-5206

Securities registered pursuant to Section 12(b) of the Act:



|                                         |  |                                     
|---------------------------------------- |  | ------------------------------------
|Title of Class                           |  | Name of Exchange on Which Registered
|Common Stock, $0.001 par value per share |  | The Nasdaq Global Market            

Securities registered pursuant to Section 12(g) of the Act: None



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Indicate by check mark if the
registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act of 1933, or the Securities Act.    Yes ̈No  x.

Indicate by check mark if the
registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Act.    Yes ̈No  x.

Indicate by check mark whether the registrant:
(1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended, or the Exchange Act, during the preceding 12 months (or for such shorter period that the registrant was required to
file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  x    No ̈

Indicate by check mark if disclosure of delinquent filers
pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any
amendment to this Form  10-K.  x

Indicate by check mark whether the registrant is a
large accelerated filer, an accelerated filer, or a non-accelerated filer. See definitions of accelerated filer and large accelerated filer in Rule 12b-2 of the Exchange Act. (Check One).

Large accelerated filer ̈Accelerated filer  x    Non-accelerated filer ̈

Indicate by check mark whether the registrant is a shell company (as defined in Exchange Act Rule 12b-2 of
the Exchange Act).    Yes ̈No  x

The aggregate market value of voting and non-voting common equity held by non-affiliates of the registrant, as of June 30, 2006, was
approximately $95,297,665 based on the closing sale price of the common stock on such date as reported on the Nasdaq Global Market. For purposes of the immediately preceding sentence, the term affiliate consists of each director and
executive officer of the registrant.

The number of shares of the registrants common stock, $0.001 par value per share, outstanding
on February 28, 2007 was 37,782,857.

DOCUMENTS INCORPORATED BY REFERENCE

Portions of the registrants Definitive Proxy Statement for its 2007 Annual Meeting of Stockholders scheduled to be held on June 26, 2007, or
the 2007 Proxy Statement, which will be filed with the Securities and Exchange Commission, or SEC, not later than 120 days after December 31, 2006, are hereby incorporated by reference into Part III of this Annual Report on Form 10-K. With the
exception of the portions of the 2007 Proxy Statement expressly incorporated into this Annual Report on Form 10-K by reference, such document shall not be deemed filed as part of this Annual Report on Form 10-K.

Icagen and our logo are our trademarks. Each of the other trademarks, trade names or service marks appearing in this prospectus belongs to its respective
holder.



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EXPLANATORY NOTE

We are filing this Amendment No. 1 to our Annual Report on Form 10-K for the fiscal year ended December 31, 2006, as originally filed with the SEC on March 6, 2007, for the sole purpose of revising the
Exhibit Index to add Exhibit 10.24. Filed as exhibits with this 10-K/A are new certifications in accordance with Rule 13a-14(a) of the Exchange Act.

This Amendment No. 1 on Form 10-K/A does not reflect events occurring after the filing of the Annual Report on Form 10-K on March 6, 2007, or modify or update the disclosures presented in the Annual Report
on Form 10-K, except to reflect the revisions as described above.



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SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.



ICAGEN, INC. (Registrant)By:

/s/ P. KAY WAGONER, PH.D.P. Kay Wagoner, Ph.D. Chief Executive Officer and President


Date: April 27, 2007



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EXHIBIT INDEX



|               |  |                                                                                                                                                                                     
|-------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit Number |  | Description                                                                                                                                                                         
|3.1(1)         |  | Restated Certificate of Incorporation of the Registrant.                                                                                                                            
|               | 
|3.2(1)         |  | Amended and Restated Bylaws of the Registrant.                                                                                                                                      
|               | 
|4.1(2)         |  | Specimen Stock Certificate.                                                                                                                                                         
|               | 
|4.2(2)         |  | Amended and Restated Stockholders Agreement, dated December 15, 2003, by and among the Registrant and the parties listed therein.                                                  
|               | 
|4.3(2)         |  | Warrant to Purchase Shares of Series B Preferred Stock, dated December 28, 1994, issued to Dominion Fund III.                                                                       
|               | 
|4.4(2)         |  | Warrant to Purchase Shares of Series D Preferred Stock, dated May 23, 1997, issued to Dominion Fund III.                                                                            
|               | 
|4.5(2)         |  | Warrant to Purchase Shares of Series E Preferred Stock, dated September 3, 1998, issued to Dominion Fund III.                                                                       
|               | 
|4.6(2)         |  | First Amendment to Warrants to Purchase Shares of Preferred Stock of Icagen, Inc., dated May 14, 2004, by and between the Registrant, Dominion Fund III and Dominion Ventures.      
|               | 
|4.7(2)         |  | Form of Warrant to Purchase Shares of Series D Convertible Preferred Stock, dated March 15, 1997, issued to certain persons in connection with offering of series D preferred
stock.
|               | 
|4.8(3)         |  | Securities Purchase Agreement, dated January 26, 2007, among the Registrant and the purchasers listed on Exhibit A thereto.                                                         
|               | 
|4.9(13)        |  | Form of Warrant to Purchase Shares of Common Stock, dated February 6, 2007, issued to certain purchasers in connection with a private placement.                                    
|               | 
|10.1*(2)       |  | 1996 Equity Compensation Plan, as amended.                                                                                                                                          
|               | 
|10.2*(1)       |  | 2004 Stock Incentive Plan.                                                                                                                                                          
|               | 
|10.3*(4)       |  | Form of Incentive Stock Option Agreement under the 2004 Stock Incentive Plan.                                                                                                       
|               | 
|10.4*(4)       |  | Form of Nonstatutory Stock Option Agreement under the 2004 Stock Incentive Plan.                                                                                                    
|               | 
|10.4.1*(5)     |  | Form of Nonstatutory Stock Option Agreement for Director Options under the 2004 Stock Incentive Plan.                                                                               
|               | 
|10.4.2*(6)     |  | Nonstatutory Stock Option Agreement, dated February 1, 2006, between the Registrant and Charles A. Sanders.                                                                         
|               | 
|10.4.3*(7)     |  | Form of Incentive Stock Option Agreement for the Retention Grant Program and Option Exchange Program under the 2004 Stock Incentive Plan.                                           
|               | 
|10.4.4*(7)     |  | Form of Non-statutory Stock Option Agreement for the Retention Grant Program and Option Exchange Program under the 2004 Stock Incentive Plan.                                       
|               | 
|10.5*(8)       |  | Form of Restricted Stock Unit Agreement under the 2004 Stock Incentive Plan.                                                                                                        
|               | 
|10.5.1*(6)     |  | Restricted Stock Unit Agreement, dated February 1, 2006, between the Registrant and Richard D. Katz.                                                                                
|               | 
|10.6*(13)      |  | Summary of Director Compensation.                                                                                                                                                   
|               | 
|10.7(13)       |  | Summary of 2007 Bonus Targets.                                                                                                                                                      
|               | 
|10.8*(6)       |  | Amended and Restated Executive Employment Agreement, dated February 1, 2006, between the Registrant and P. Kay Wagoner.                                                             
|               | 
|10.9*(6)       |  | Amended and Restated Executive Employment Agreement, dated February 1, 2006, between the Registrant and Richard D. Katz.                                                            



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|          |  |                                                                                                                                                                 
|--------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------
|10.10*(9) |  | Executive Employment Agreement, dated May 24, 2006, between the Registrant and Seth V. Hetherington.                                                            
|          | 
|10.11*(6) |  | Executive Employment Agreement, dated February 1, 2006, between the Registrant and Edward P. Gray.                                                              
|          | 
|10.12(2)  |  | Lease Agreement, dated December 17, 1992, between the Registrant and Royal Center IC, LLC, successor in interest to Petula Associates, LTD., as amended.        
|          | 
|10.13(10) |  | Sixth Amendment to Lease, dated August 3, 2005, by and between the Registrant and Royal Center IC, LLC.                                                         
|          | 
|10.14(2)  |  | Lease Agreement, dated October 1997, between the Registrant and Royal Center IC, LLC, successor in interest to Petula Associates, LTD., as amended.             
|          | 
|10.15(2)  |  | Sublease Agreement, dated September 22, 1997, between the Registrant and Inspire Pharmaceuticals, Inc., as amended.                                             
|          | 
|10.16(2)  |  | Master Loan and Security Agreement, dated July 14, 1999, between the Registrant and Oxford Venture Finance, as amended.                                         
|          | 
|10.17(11) |  | Letter Agreement, dated April 15, 2005, from Oxford Finance Corporation to the Registrant.                                                                      
|          | 
|10.18(12) |  | Letter Agreement, dated February 14, 2006, from Oxford Finance Corporation to the Registrant.                                                                   
|          | 
|10.19(2) |  | Collaborative Research and License Agreement, dated March 21, 2000, between the Registrant and Astellas Pharma Inc., as amended.                                
|          | 
|10.20(2) |  | Exclusive License Agreement, dated February 29, 2000, between the Registrant and Childrens Medical Center Corporation, as amended.                             
|          | 
|10.21(2)  |  | Clinical Trials Master Services Agreement, dated December 14, 1998, between the Registrant and Quintiles Transnational Corp.                                    
|          | 
|10.22(2) |  | Collaboration Agreement, dated June 14, 2004, between the Registrant and the McNeil Consumer & Specialty Pharmaceuticals Division of McNeil-PPC, Inc.           
|          | 
|10.23(2) |  | Copromotion Agreement, dated June 14, 2004, between the Registrant and the McNeil Consumer & Specialty Pharmaceuticals Division of McNeil-PPC, Inc.             
|          | 
|10.24(2) |  | Collaborative Research and License Agreement, dated October 1, 1997, between the Registrant and Bristol-Myers Squibb Company, as amended.                       
|          | 
|23.1(13)  |  | Consent of Independent Registered Public Accounting Firm.                                                                                                       
|          | 
|31.1(13)  |  | Certification of Chief Executive Officer and President pursuant to Exchange Act Rule 13a-14(a).                                                                 
|          | 
|31.2(13)  |  | Certification of the Chief Financial Officer pursuant to Exchange Act Rule 13a-14(a).                                                                           
|          | 
|31.3      |  | Certification of Chief Executive Officer and President pursuant to Exchange Act Rule 13a-14(a).                                                                 
|          | 
|31.4      |  | Certification of the Chief Financial Officer pursuant to Exchange Act Rule 13a-14(a).                                                                           
|          | 
|32.1(13)  |  | Certification of Chief Executive Officer and President pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.
|          | 
|32.2(13)  |  | Certification of the Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.          

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|(1) | Incorporated by reference to the exhibits to the Registrants Annual Report on Form 10-K filed with the SEC on March 31, 2005.
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|(2) | Incorporated by reference to the exhibits to the Registrants Registration Statement on Form S-1 (File No. 333-114336).
|--- | -----------------------------------------------------------------------------------------------------------------------

|(3) | Incorporated by reference to the exhibits to the Registrants Current Report on Form 8-K filed with the SEC on January 31, 2007.
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|(4) | Incorporated by reference to the exhibits to the Registrants Quarterly Report on Form 10-Q filed with the SEC on May 11, 2006.
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|(5) | Incorporated by reference to the exhibits to the Registrants Current Report on Form 8-K filed with the SEC on March 16, 2005.
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|(6) | Incorporated by reference to the exhibits to the Registrants Current Report on Form 8-K filed with the SEC on February 1, 2006.
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|(7) | Incorporated by reference to the exhibits to the Registrants Quarterly Report on Form 10-Q filed with the SEC on November 14, 2006.
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|(8) | Incorporated by reference to the exhibits to the Registrants Current Report on Form 8-K filed with the SEC on January 19, 2007.
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|(9) | Incorporated by reference to the exhibits to the Registrants Current Report on Form 8-K filed with the SEC on May 30, 2006.
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|(10) | Incorporated by reference to the exhibits to the Registrants Current Report on Form 8-K filed with the SEC on August 9, 2005.
|---- | ------------------------------------------------------------------------------------------------------------------------------

|(11) | Incorporated by reference to the exhibits to the Registrants Current Report on Form 8-K filed with the SEC on April 19, 2005.
|---- | ------------------------------------------------------------------------------------------------------------------------------

|(12) | Incorporated by reference to the exhibits to the Registrants Current Report on Form 8-K filed with the SEC on February 21, 2006.
|---- | ---------------------------------------------------------------------------------------------------------------------------------

|(13) | Incorporated by reference to the exhibits to the Registrants Annual Report on Form 10-K originally filed with the SEC on March 6, 2007.
|---- | ----------------------------------------------------------------------------------------------------------------------------------------

| | Confidential treatment granted by the SEC as to certain portions.
|- | -----------------------------------------------------------------

|* | Management contract or compensatory plan or arrangement filed herewith in response to Item 15(a) of Form 10-K.
|- | --------------------------------------------------------------------------------------------------------------



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