<PAGE>   1

                                                                     EXHIBIT 4.1

                          REGISTRATION RIGHTS AGREEMENT

         THIS REGISTRATION RIGHTS AGREEMENT (this "Agreement") is made and
entered into as of June 4, 2001, by and among SPECTRX, INC., a Delaware
corporation (the "Company"), and those purchasers of the Company's common stock
set forth on Schedule I hereto (the "Purchasers").

         This Agreement is made pursuant to the Stock Purchase Agreement, dated
as of June 4, 2001 (the "Stock Purchase Agreement"), by and between the Company
and the Purchasers, pursuant to which the Company is issuing to the Purchasers
1,500,000 shares (the "Common Shares") of its common stock, $.001 par value per
share (the "Common Stock") and warrants to purchase 300,000 shares of the Common
Stock (the "Warrants"). The execution and delivery of this Agreement is a
condition to the closing (the "Closing") under the Stock Purchase Agreement.

         In consideration of the foregoing premises and for other good and
valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the parties hereby agree as follows:

1.       REGISTRATION RIGHTS

(a) Filing of Form S-3 "Resale" Registration Statement. Within 30 days following
the date of the Closing, the Company shall use its best efforts to file with the
Securities and Exchange Commission (the "Commission") a "resale" registration
statement on Form S-3 pursuant to Rule 415 under the Securities Act of 1933, as
amended (the "Securities Act") (together with any exhibits, amendments or
supplements thereto, and any documents incorporated by reference therein, the
"Registration Statement") with respect to (i) the Common Shares, (ii) the shares
of Common Stock issuable pursuant to the exercise of the Warrants (the "Warrant
Shares"), (iii) the shares of Common Stock issuable pursuant to the exercise of
the Additional Warrants (as defined in Section 1(d)) (the "Additional Warrant
Shares") and (iv) any securities of the Company issued as a dividend or other
distribution with respect to, or in exchange for or in replacement of, the
Common Shares, the Warrant Shares or the Additional Warrant Shares.

         The securities described in the preceding sentence are collectively
referred to herein as the "Registrable Securities"; provided, that the term
"Registrable Securities" shall not include securities sold pursuant to the
Registration Statement or transferred to a person other than a Permitted
Transferee as defined in Section 8(a) herein.

         The Registration Statement may include securities of the Company other
than Registrable Securities.
<PAGE>   2

         (b) Effectiveness of Registration Statement. The Company shall, subject
to Section 6 hereof, use its best efforts to cause the Registration Statement to
become effective as soon as practicable after the filing thereof, and shall use
its best efforts to keep the Registration Statement continuously effective from
the date such Registration Statement becomes effective until the earliest of (i)
the date on which all such Securities have been disposed of in accordance with
such Registration Statement, (ii) the date on which all Registrable Securities
are eligible to be sold pursuant to Rule 144(k) and (iii) the second anniversary
of the date such Registration Statement becomes effective (the "Termination
Date").

         (c) Supplements; Amendments. In the event that any securities are
issued in respect of the Common Shares, the Warrant Shares or the Additional
Warrant Shares, the Company shall cause such additional securities that become
Registrable Securities to be registered under the Securities Act.

         (d) Additional Warrants.

                  (i)      If the Company does not file the Registration
                  Statement on or before the date that is 30 days after the date
                  of the Closing, then for each 30 day period between 30 days
                  after the date of the Closing and the date the Registration
                  Statement is filed, the Company hereby covenants and agrees to
                  grant to each Purchaser a warrant to purchase a number of
                  shares of Common Stock equal to 5% of the number of Common
                  Shares issued to each Purchaser pursuant to the Stock Purchase
                  Agreement (an "Additional Warrant").

                  (ii)     If the Registration Statement does not become
                  effective on or before the date that is 90 days after the date
                  of the Closing, then for each 30 day period between 90 days
                  after the date of the Closing and the date the Registration
                  Statement first becomes effective, the Company hereby
                  covenants to grant to each Purchaser an Additional Warrant.

                  (iii)    Any Additional Warrants issued pursuant to
                  immediately preceding subsections (i) and (ii) shall be in a
                  form substantially identical (including the exercise price) to
                  Exhibit A of the Stock Purchase Agreement.

                  (iv)     Notwithstanding the foregoing, in no event will the
                  Company be required, pursuant to this Section 1(d), to issue
                  Additional Warrants for more than an aggregate of 300,000
                  shares of Common Stock.

2.       EXPENSES

         The Company shall bear all expenses, fees and costs incurred in
connection with the preparation, filing, distribution and effectiveness of the
Registration Statement and any supplements or amendments thereto, whether or not
the Registration Statement becomes effective, and whether all, none or some of
the Registrable Securities are sold pursuant to the Registration Statement,
including, without limitation, all registration and filing fees, printing
expenses, fees and disbursements of counsel for the Company, fees and state
securities, or "blue sky," fees and expenses and the expense of any special
audits incident to or required by, or in connection with the filing and
effectiveness of the Registration Statement (but excluding the


                                       2
<PAGE>   3

compensation of regular employees of the Company, which shall be paid in any
event by the Company), and the Holder shall pay all selling commissions,
brokerage fees and stock transfer taxes applicable to the securities sold by
such holder.

3.       REGISTRATION PROCEDURES

         The Company will promptly advise the Purchasers and their permitted
transferees ("the Holders") of the filing and effectiveness of the Registration
Statement and, at the Company's expense, will:

         (a) furnish to each Holder copies of the Registration Statement
(excluding exhibits thereto) and any prospectus forming a part thereof and any
amendments and supplements thereto (including all documents incorporated or
deemed incorporated by reference therein prior to the effectiveness of the
Registration Statement and including each preliminary prospectus) and any other
prospectus filed under Rule 424 under the Securities Act, which documents, other
than documents incorporated or deemed incorporated by reference, will be subject
to the review of the Holders for a period of at least two (2) business days, and
the Company shall not file the Registration Statement or such prospectus or any
amendment or supplement to the Registration Statement or prospectus if any
Holder shall reasonably object within two (2) business days after the receipt
thereof; a Holder shall be deemed to have reasonably objected to such filing
only if the Registration Statement, amendment, prospectus or supplement, as
applicable, as proposed to be filed, contains a material misstatement or
omission with respect to such Holder or its plan of resale;

         (b) furnish to each Holder one conformed copy of the Registration
Statement and of each amendment and supplement thereto (in each case excluding
exhibits) and such number of copies of the prospectus forming a part of the
Registration Statement (including each preliminary prospectus) and any other
prospectus filed under Rule 424 under the Securities Act, and such other
documents, including, without limitation, documents incorporated or deemed to be
incorporated by reference prior to the effectiveness of such registration
statement, as each of the Holders from time to time may reasonably request;

         (c) to the extent practicable, promptly upon the filing of any document
that is to be incorporated by reference into the Registration Statement or
prospectus forming a part thereof subsequent to the effectiveness thereof, and
in any event no later than five (5) business days after such document is filed
with the Commission, provide copies of such document to the Holders, if
requested, and make representatives of the Company available for discussion of
such document and other customary due diligence matters;

         (d) make available, at reasonable times for inspection by the Holders,
and any attorney, accountant, financial adviser or other representative
(collectively, "Representatives") retained by the Holders, subject to the
recipient's prior agreement to keep such information confidential and not use or
disclose it, all financial and other records, pertinent corporate documents and
properties of the Company and cause the officers, directors and employees of the
Company to supply all information reasonably requested by the Holders or their
respective Representatives in connection with the preparation, filing and
effectiveness of the Registration Statement;


                                       3
<PAGE>   4

         (e) use its reasonable best efforts (i) to register or qualify all
Registrable Securities covered by the Registration Statement under state
securities, or "blue sky," laws of such States of the United States of America
as the Holders of Registrable Securities covered by the Registration Statement
shall reasonably request, (ii) to keep such registration or qualification in
effect for so long as the Registration Statement remains in effect, and (iii) to
take any other action which may be reasonably necessary or advisable to enable
the Holders to consummate the disposition in such jurisdictions of the
securities to be sold by the Holders, consistent with the plan of distribution
described in the prospectus included in the Registration Statement, except that
the Company shall not for any such purpose be required to qualify generally to
do business as a foreign corporation in any jurisdiction where it is not so
qualified, or to subject itself to taxation in any such jurisdiction, or to
execute a general consent to service of process in effecting such registration,
qualification or compliance, unless the Company is already subject to service in
such jurisdiction and except as may be required by the Securities Act or
applicable rules or regulations thereunder;

         (f) subject to Section 6 hereof, promptly notify each Holder of
Registrable Securities covered by the Registration Statement (i) upon discovery
that, or upon the happening of any event as a result of which, the prospectus
forming a part of the Registration Statement, as then in effect, includes an
untrue statement of a material fact or omits to state any material fact required
to be stated therein or necessary to make the statements therein, in the light
of the circumstances under which they were made, not misleading, (ii) of the
issuance by the Commission of any stop order suspending the effectiveness of the
Registration Statement or the initiation of proceedings for that purpose, (iii)
of any request by the Commission for (A) amendments to the Registration
Statement or any document incorporated or deemed to be incorporated by reference
in the Registration Statement or (B) supplements to the prospectus forming a
part of the Registration Statement, or (iv) of the receipt by the Company of any
notification with respect to the suspension of the qualification or exemption
from qualification of any of the Registrable Securities for sale in any
jurisdiction or the initiation of any proceeding for such purpose, and at the
request of any such Holder promptly prepare and file an amendment to the
Registration Statement or a supplement to the prospectus as the Company may deem
necessary so that, as thereafter delivered to the purchasers of such securities,
such prospectus shall not include an untrue statement of a material fact or omit
to state a material fact required to be stated therein or necessary to make the
statements therein, in the light of the circumstances under which they were
made, not misleading and furnish to each Holder a reasonable number of copies of
such supplement to, or amendment of, such prospectus and, in the event of a stop
order, use its reasonable best efforts to obtain the withdrawal of any order
suspending the effectiveness of any the Registration Statement, or the lifting
of any suspension of the qualification (or exemption from qualification) of any
of the Registrable Securities for sale in any jurisdiction;

         (g) if requested by any Holder, promptly incorporate in the
Registration Statement by filing a Form 8-K or filing a supplement to the
prospectus, if necessary, to reflect any change in the information regarding the
Holder;

         (h) otherwise use its reasonable best efforts to comply with all
applicable rules and regulations of the Commission, and make available to its
security holders, as soon as reasonably practicable, an earnings statement
covering the period of at least 12 months, but not more than 18 months,
beginning with the first full calendar month after the effective date of the
Registration


                                       4
<PAGE>   5

Statement, which earnings statement shall satisfy the provisions of Section
11(a) of the Securities Act and Rule 158 promulgated thereunder;

         (i) use its best efforts to cause all Registrable Securities included
in the Registration Statement to be listed on the Nasdaq National Market or each
securities exchange on which securities of the same class are then listed, or,
if not then listed on any securities exchange, to be eligible for trading in any
over-the-counter market or trading system in which securities of the same class
are then traded.

4.       INDEMNIFICATION

         (a) Indemnification by the Company. The Company will indemnify:

                  (i)      each of the Holders, as applicable,

                  (ii)     any underwriter (as defined in the Securities Act)
                  for a Holder,

                  (iii)    each of the officers, directors, trustees, members
                  and partners of each of the Holders and any underwriter for a
                  Holder, and

                  (iv)     each individual, partnership, joint stock company,
                  corporation, trust, unincorporated organization, government
                  agency or political subdivision (each of the foregoing, a
                  "Person") controlling each of the Holders or any underwriter
                  for a Holder (each of (i) through (iv), an "Indemnified
                  Person"),

with respect to the Registration Statement, against all expenses, claims,
losses, damages and liabilities (including in settlement of litigation) (or
actions, investigations or proceedings in respect thereof) (collectively, a
"Claim") arising out of or based on any untrue statement (or alleged untrue
statement) of a material fact contained in the Registration Statement or any
prospectus, offering circular or other document (including any related
registration statement, notification or the like) incident to the registration,
qualification or compliance, or based on any omission (or alleged omission) to
state therein a material fact required to be stated therein or necessary to make
the statements therein, in light of the circumstances in which they were made,
not misleading, or any violation (or alleged violation) by the Company of the
Securities Act, the Exchange Act or any other law, including any state
securities law, or any rule or regulation thereunder, and will reimburse each
Indemnified Person promptly as such expenses are incurred, for any legal and any
other expenses reasonably incurred in connection with investigating or defending
any such Claim; provided, however, that the Company will not be liable to any
Indemnified Person to the extent that any such Claim arises out of or is based
on any untrue statement or omission based upon and in conformity with written
information furnished to the Company by the Holders or their representatives and
stated to be specifically for use in the Registration Statement. This indemnity
obligation will remain in full force and effect regardless of any investigation
made by or on behalf of the Indemnified Persons and will survive any transfer of
the Registrable Securities by the Holders.

         (b) Indemnification by the Holders. Each of the Holders will, if
Registrable Securities held by it are included in the securities as to which
such Registration Statement is being effected, indemnify the Company, each of
its directors and officers, and each Person who controls the


                                       5
<PAGE>   6

Company, against all Claims arising out of or based on any untrue statement (or
alleged untrue statement) of a material fact contained in the Registration
Statement or any prospectus, offering circular or other document made by or on
behalf of such Holder, or any omission (or alleged omission) to state therein a
material fact required to be stated therein or necessary to make the statements
by or on behalf of such Holder therein, in light of the circumstances in which
they were made, not misleading, and will reimburse the Company, its directors,
officers, partners, members or control Persons for any legal or any other
expenses reasonably incurred in connection with investigating or defending any
such Claim, in each case to the extent, but only to the extent, that such untrue
statement (or alleged untrue statement) or omission (or alleged omission) is
made in the Registration Statement or any prospectus, offering memorandum or
other document in reliance upon and in conformity with written information
furnished to the Company by or on behalf of such Holder and stated to be
specifically for use therein; provided, however, that the obligations of each of
the Holders hereunder shall be limited to an amount equal to the net proceeds to
such Holder of securities sold as contemplated herein.

         (c) Procedures. Each party entitled to indemnification under this
Agreement (the "Indemnified Party") shall give notice to the party required to
provide indemnification (the "Indemnifying Party") promptly after such
Indemnified Party has actual knowledge of any Claim as to which indemnity may be
sought, and shall permit the Indemnifying Party to assume the defense of any
such Claim; provided that counsel for the Indemnifying Party, who shall conduct
the defense of such Claim, shall be approved by the Indemnified Party (whose
approval shall not unreasonably be withheld), and the Indemnified Party may
participate in such defense at such party's expense (unless the Indemnified
Party shall have reasonably concluded that there may be a conflict of interest
between the Indemnifying Party and the Indemnified Party in such action, in
which case the fees and expenses of one such counsel for all Indemnified Parties
shall be at the expense of the Indemnifying Party), and provided further that
the failure of any Indemnified Party to give notice as provided herein shall not
relieve the Indemnifying Party of its obligations under this Agreement except to
the extent that the Indemnifying Party is prejudiced thereby. No Indemnifying
Party, in the investigation or defense of any such Claim shall, except with the
consent of each Indemnified Party (which consent shall not be unreasonably
withheld or delayed), consent to entry of any judgment or enter into any
settlement or compromise which does not include an unconditional release of the
Indemnifying Party from all liability in respect to such Claim. Each Indemnified
Party shall furnish such information regarding itself or the Claim in question
as an Indemnifying Party may reasonably request in writing and as shall be
reasonably required in connection with the investigation and defense of such
Claim.

         (d) Contribution. If the indemnification provided for in this Agreement
is held by a court of competent jurisdiction to be unavailable to an Indemnified
Party with respect to any Claim, then the Indemnifying Party, in lieu of
indemnifying such Indemnified Party hereunder, shall contribute to the amount
paid or payable by such Indemnified Party as a result of such loss, liability,
claim, damage or expense in such proportion as is appropriate to reflect the
relative fault of the Indemnifying Party on the one hand and of the Indemnified
Party on the other in connection with the statements or omissions which resulted
in such Claim, as well as any other relevant equitable considerations. The
relative fault of the Indemnifying Party and of the Indemnified Party shall be
determined by reference to, among other things, whether the untrue (or alleged
untrue) statement of a material fact or the omission (or alleged omission) to
state a material fact relates to information supplied by the Indemnifying Party
or by the Indemnified


                                       6
<PAGE>   7

Party and the parties' relative intent, knowledge, access to information and
opportunity to correct or prevent such statement or omission. Contribution
(together with any indemnification or other obligations under this Section 4) by
any Holder (including any Indemnified Person associated with such Holder) shall
be limited in amount to the net amount of proceeds received by such Holder from
the sale of Registrable Securities by it.

5.       PROVISION OF INFORMATION BY THE HOLDERS

         Each of the Holders whose Registrable Securities are included in the
Registration Statement shall furnish to the Company such information regarding
such Holder as the Company may reasonably request in writing and as shall be
reasonably required in connection with any registration, qualification or
compliance referred to in this Agreement, and shall promptly notify the Company
if such information becomes incorrect or misleading, or requires amendment or
updating. Each of the Holders agrees that the plan of distribution included in
any prospectus relating to the Registrable Securities shall be as set forth in
Schedule III hereto and that such Holder will not sell any Securities in any
manner other than as provided therein. Each Holder represents and warrants to
the Company that the information regarding such Holder set forth on Schedule II
is accurate and complete in all material respects.

6.       HOLDBACK; POSTPONEMENT

         Notwithstanding the other provisions of this Agreement, if the Board of
Directors of the Company determines in good faith that it is in the best
interests of the Company (i) not to disclose the existence of facts surrounding
any proposed or pending acquisition, disposition, strategic alliance or
financing transaction involving the Company, or (ii) for any purpose, to suspend
the registration rights set forth herein, the Company may, by prompt notice to
the Holders, (A) suspend the rights of the Holders to make sales pursuant to the
Registration Statement, and/or (B) postpone the preparation, filing and
effectiveness of the Registration Statement, in each case for such a period of
time as the Board of Directors may reasonably determine; provided that such
periods of suspension may not exceed 90 days in the aggregate in any consecutive
12 month period.

7.       RULE 144 REPORTING

         With a view to making available the benefits of certain rules and
regulations of the Commission which may at any time permit the sale of the
Registrable Securities to the public without registration, until the second
anniversary of the date the Closing, the Company agrees to:

                  (i)      Make and keep adequate current public information
                  available, as those terms are understood and defined in Rule
                  144 under the Act;

                  (ii)     Use its best efforts to file with the Commission in a
                  timely manner all reports and other documents required of the
                  Company under the Act and the Securities Exchange Act of 1934,
                  as amended; and

                  (iii)    So long as a Holder owns any Registrable Securities
                  to furnish to the Holder forthwith upon request a written
                  statement by the Company as to its compliance with the
                  reporting requirements of said Rule 144, and of the Act and


                                       7
<PAGE>   8

                  the Securities Exchange Act of 1934, a copy of the most recent
                  annual or quarterly report of the Company, and such other
                  reports and documents of the company and other information in
                  the possession of or reasonably obtainable by the Company as a
                  Holder may reasonably request in availing itself of any rule
                  or regulation of the Commission allowing a Holder to sell any
                  such securities without registration.

8.       MISCELLANEOUS

         (a) Assignment. The registration rights set forth herein may be
assigned, in whole or in part, to any transferee of Registrable Securities
permitted in accordance with the Stock Purchase Agreement, which transferee,
upon registration on the Company's or its transfer agent's books and records as
a holder of record of Registrable Securities, shall be considered thereafter to
be a Holder and shall be bound by all obligations and limitations of this
Agreement and the Stock Purchase Agreement, provided, however that assignment
will only be available if (i) such transfer may otherwise be effected in
accordance with applicable securities laws and (ii) such assignee or transferee
acquires at least 500,000 shares of Registrable Securities or is an affiliate
(as such term is defined in Rule 144 under the Securities Act) of a Holder (a
"Permitted Transferee").

         (b) Interpretation.

                  (i)      Directly or Indirectly. Where any provision in this
                  Agreement refers to action to be taken by any Person, or which
                  such Person is prohibited from taking, such provision shall be
                  applicable whether such action is taken directly or indirectly
                  by such Person.

                  (ii)     Governing Law. This Agreement shall be governed by
                  and construed in accordance with the laws of the State of
                  Georgia.

                  (iii)    Section Headings. The headings of the sections and
                  subsections of this Agreement are inserted for convenience
                  only and shall not be deemed to constitute a part thereof.

         (c) Notices.

                  (i)      All communications under this Agreement shall be in
                  writing and shall be delivered by facsimile or by hand or
                  mailed by overnight courier or by registered or certified
                  mail, postage prepaid:

                           (A)      if to the Company, to SpectRx, Inc., 6025A
                           Unity Drive, Norcross, Georgia 30071, facsimile (770)
                           242-8639, Attention: Thomas H. Muller, Jr. or at such
                           other address as it may have furnished in writing to
                           the Purchasers;

                           (B)      if to the Purchasers, at the addresses
                           listed on Schedule I hereto, or at such other
                           addresses as may have been furnished the Company in
                           writing.


                                       8
<PAGE>   9

                  (ii)     Any notice so addressed shall be deemed to be given
                  (A) if delivered by facsimile or by hand, on the date of such
                  delivery, (B) if mailed by overnight mail service, on the
                  first business day following the date of such mailing, or (C)
                  if mailed by registered or certified mail, on the third
                  business day after the date of such mailing.

         (d) Reproduction of Documents. This Agreement and all documents
relating thereto, including, without limitation, any consents, waivers and
modifications which may hereafter be executed may be reproduced by the
Purchasers by any photographic, photostatic, microfilm, microcard, miniature
photographic or other similar process and the Purchasers may destroy any
original document so reproduced. The parties hereto agree and stipulate that any
such reproduction shall be admissible in evidence as the original itself in any
judicial or administrative proceeding (whether or not the original is in
existence and whether or not such reproduction was made by the Investors in the
regular course of business) and that any enlargement, facsimile or further
reproduction of such reproduction shall likewise be admissible in evidence.

         (e) Successors and Assigns. This Agreement shall inure to the benefit
of and be binding upon the successors and permitted assigns of each of the
parties.

         (f) Entire Agreement; Amendment and Waiver. This Agreement constitutes
the entire understanding of the parties hereto in respect of the subject matter
hereof and supersedes all prior understanding among such parties as to same.
This Agreement may be amended, and the observance of any term of this Agreement
may be waived only with the written consent of the Company and the Holders of a
majority of the then outstanding Registrable Securities.

         (g) Counterparts. This Agreement may be executed in one or more
counterparts, each of which shall be deemed an original and all of which
together shall be considered one and the same agreement.

         (h) Remedies. Each Holder of Registrable Securities, in addition to
being entitled to exercise all rights granted by law, including recovery of
damages, will be entitled to specific performance of its rights under this
Agreement. The Company agrees that monetary damages would not be adequate
compensation for any loss incurred by reason of a breach by it of the provisions
of this Agreement and hereby agrees to waive the defense in any action for
specific performance that a remedy at law would be adequate.

         (i) Severability. In the event that any one or more of the provisions
contained herein, or the application thereof in any circumstances, is held
invalid, illegal or unenforceable in any respect for any reason, the validity,
legality and enforceability of the remaining provisions contained herein shall
not be in any way impaired thereby, and shall remain in full force and effect,
it being intended and understood that all of the rights and privileges of each
of the Holders shall be enforceable to the fullest extent permitted by law.

         (j) No Grant of Registration Rights to Third Parties. The Company
hereby covenants and agrees that it will not grant registration rights to or
register any securities of any third party before the Registration Statement
becomes effective that would adversely affect the ability of the


                                       9
<PAGE>   10

Company to register the Registrable Securities subject to the terms and
conditions of this Agreement.

         (k) Termination of Registration Rights. All rights of the Holders under
this Agreement shall terminate on the Termination Date.

         (l) Delays or Omissions. It is agreed that no delay or omission to
exercise any right, power or remedy accruing to the Holders, upon any breach or
default of the Company under this Agreement, shall impair any such right, power
or remedy, nor shall it be construed to be a waiver of any such breach or
default, or any acquiescence therein, or of any similar breach or default
thereafter occurring; nor shall any waiver of any single breach or default be
deemed a waiver of any other breach or default theretofore or thereafter
occurring. It is further agreed that any waiver, permit, consent or approval of
any kind or character by a Holder of any breach or default under this Agreement,
or any waiver by a Holder of any provisions or conditions of this Agreement must
be in writing and shall be effective only to the extent specifically set forth
in writing and that all remedies, either under this Agreement, or by law or
otherwise afforded to a Holder, shall be cumulative and not alternative.

         (m) Attorneys' Fees. If any action at law or in equity is necessary to
enforce or interpret the terms of this Agreement, the prevailing party shall be
entitled to reasonable attorneys' fees, costs and necessary disbursements in
addition to any other relief to which such party may be entitled.

                         [SIGNATURES ON FOLLOWING PAGE]


                                       10
<PAGE>   11

         IN WITNESS WHEREOF, the undersigned, thereunto duly authorized, have
executed this Agreement as of the date first set forth above.

                                 SPECTRX, INC.



                                 By:   /S/  Thomas H. Muller, Jr.
                                    -------------------------------------------
                                    Name:  Thomas H. Muller, Jr.
                                           ------------------------------------
                                    Title: Executive Vice President & CFO
                                           ------------------------------------



                                 PURCHASERS:

                                 SAFECO COMMON STOCK TRUST --
                                 SAFECO GROWTH OPPORTUNITIES FUND

                                 By:   /S/  Ronald L. Spaulding
                                    -------------------------------------------
                                    Name:  Ronald L. Spaulding
                                           ------------------------------------
                                    Title: Vice President & Treasurer
                                           ------------------------------------



                                 SAFECO RESOURCE SERIES TRUST --
                                 GROWTH OPPORTUNITIES PORTFOLIO

                                 By:    /S/  Ronald L. Spaulding
                                    -------------------------------------------
                                    Name:  Ronald L. Spaulding
                                           ------------------------------------
                                    Title: Vice President & Treasurer
                                           ------------------------------------



                                 SAFECO DIVERSIFIED COMMON STOCK
                                 PORTFOLIO

                                 By SAFECO CORPORATION, as Plan
                                 Sponsor of the SAFECO 401(k) Savings Plan



                                 By:  /S/  Ronald L. Spaulding
                                    -------------------------------------------
                                    Name:  Ronald L Spaulding
                                           ------------------------------------
                                    Title: Treasurer & Chief Investment Officer
                                           ------------------------------------


                                       11
<PAGE>   12

                                   SCHEDULE I



                                 THE PURCHASERS


<TABLE>
<CAPTION>
                  NAME                                                    ADDRESS
-----------------------------------------                    --------------------------------------
<S>                                                          <C>
SAFECO Common Stock Trust - SAFECO                           c/o SAFECO Corporation
Growth Opportunities Fund                                    Corporate Legal Department
                                                             SAFECO Plaza, T-18
                                                             Seattle, WA 98185

SAFECO Resource Series Trust - Growth                        c/o SAFECO Corporation
Opportunities Portfolio                                      Corporate Legal Department
                                                             SAFECO Plaza, T-18
                                                             Seattle, WA 98185

SAFECO Diversified Common Stock Portfolio                    c/o SAFECO Corporation
                                                             Corporate Legal Department
                                                             SAFECO Plaza, T-18
                                                             Seattle, WA 98185
</TABLE>


                                       12
<PAGE>   13

                                   SCHEDULE II

                               HOLDER INFORMATION

SAFECO Growth Opportunities Fund

Name in which shares are registered:     Coralbasin & Co.
                                         ----------------

Name of beneficial owner, if different:  SAFECO COMMON STOCK TRUST - SAFECO
                                         ----------------------------------
                                         Growth Opportunities Fund
                                         -------------------------
The following describes the nature of any position, office or other material
relationship which the Holder has had within the past three years with SpectRx,
Inc. and any of its affiliates:

                  None
--------------------------------------------------------------------------------

The following is the number of shares of any class of stock of SpectRx, Inc.
(indicating the class) and each other right, option or warrant to acquire any
shares of any class of stock of SpectRx, Inc. beneficially owned (within the
meaning of Rule 13d-3 under the Securities Exchange Act of 1934, as amended) by
the Holder, prior to the investment under the Stock Purchase Agreement:

                  None
--------------------------------------------------------------------------------

The Holder intends to offer the following number of shares of common stock of
SpectRx, Inc. under the Registration Statement:

                  861,000 shares, plus 172,200 shares underlying warrants
--------------------------------------------------------------------------------

SAFECO RST Growth Opportunities Fund

Name in which shares are registered:     Coralrock & Co.
                                         ---------------

Name of beneficial owner, if different:  SAFECO RESOURCES SERIES TRUST -
                                         -------------------------------
                                         SAFECO Growth Opportunities Portfolio
                                         -------------------------------------

The following describes the nature of any position, office or other material
relationship which the Holder has had within the past three years with SpectRx,
Inc. and any of its affiliates:

                  None
--------------------------------------------------------------------------------

The following is the number of shares of any class of stock of SpectRx, Inc.
(indicating the class) and each other right, option or warrant to acquire any
shares of any class of stock of SpectRx, Inc. beneficially owned (within the
meaning of Rule 13d-3 under the Securities Exchange Act of 1934, as amended) by
the Holder, prior to the investment under the Stock Purchase Agreement:

                  None
--------------------------------------------------------------------------------


                                       13
<PAGE>   14

The Holder intends to offer the following number of shares of common stock of
SpectRx, Inc. under the Registration Statement:

                  464,000 shares, plus 92,800 shares underlying warrants
--------------------------------------------------------------------------------

SAFECO Diversified Common Stock Portfolio

Name in which shares are registered:     Mac & Co.
                                         ---------

Name of beneficial owner, if different:  SAFECO Diversified
                                         ------------------
                                         Common Stock Portfolio
                                         ----------------------

The following describes the nature of any position, office or other material
relationship which the Holder has had within the past three years with SpectRx,
Inc. and any of its affiliates:

                  None
--------------------------------------------------------------------------------

The following is the number of shares of any class of stock of SpectRx, Inc.
(indicating the class) and each other right, option or warrant to acquire any
shares of any class of stock of SpectRx, Inc. beneficially owned (within the
meaning of Rule 13d-3 under the Securities Exchange Act of 1934, as amended) by
the Holder, prior to the investment under the Stock Purchase Agreement:

                  None
--------------------------------------------------------------------------------

The Holder intends to offer the following number of shares of common stock of
SpectRx, Inc. under the Registration Statement:

                  175,000 shares, plus 35,000 shares underlying warrants
--------------------------------------------------------------------------------


                                       14
<PAGE>   15

                                  SCHEDULE III


                              PLAN OF DISTRIBUTION

         Any or all of the shares offered by the selling stockholders may be
offered for sale and sold by or on behalf of the selling stockholders from time
to time in varying amounts, including in block transactions, on the Nasdaq Stock
Market or the over-the-counter market, in privately negotiated transactions, or
otherwise (other than underwritten offerings), at prices prevailing in such
market or as may be negotiated at the time of the sale. The shares may be sold
by the selling stockholders directly to one or more purchasers, through agents
designated from time to time or to or through broker-dealers designated from
time to time. In the event the shares are publicly offered through
broker-dealers or agents, the selling stockholders may enter into agreements
with respect thereto. Such broker-dealers or agents may receive compensation in
the form of discounts, concessions or commissions from the selling stockholders
and/or the purchasers of the shares. The selling stockholders and any such
broker-dealers or agents that participate in the distribution of the shares may
be deemed to be underwriters within the meaning of the Securities Act, and any
profit on the sale of the shares by them and any discounts, commissions or
concessions received by them may be deemed to be underwriting discounts and
commissions under the Securities Act. Any such broker-dealers and agents may
engage in transactions with, and perform services for, the Company. At the time
a particular offer of shares is made by the selling stockholders, to the extent
required, a prospectus supplement will be distributed which will set forth the
aggregate number of shares being offered, and the terms of the offering,
including the public offering price thereof, the name or names of any
broker-dealers or agents, any discounts, commissions and other items
constituting compensation from, and the resulting net proceeds to, the selling
stockholders.

         In order to comply with the securities laws of certain states, sales of
shares offered hereby to the public in such states may be made only through
broker-dealers who are registered or licensed in such states. Sales of shares
offered hereby must also be made by the selling stockholders in compliance with
other applicable state securities laws and regulations.


                                       15