EXHIBIT 10.14

BRIDGE NOTE

$3,000,000                                        JUNE 19, 2000

     FOR  VALUE  RECEIVED,   INFORMAX,   Inc.,  a  Delaware   corporation   (the
"BORROWER"), promises to pay to the order of PNC BANK, NATIONAL ASSOCIATION (the
"BANK"),  in  lawful  money of the  United  States  of  America  in  immediately
available  funds,  the  principal  sum of the  lesser of THREE  MILLION  DOLLARS
($3,000,000)  or the aggregate  unpaid  principal  amount  outstanding as of the
Bridge Loan Expiration Date,  together with interest accruing on the outstanding
principal balance from the date hereof, as provided below:

     1.  AMENDMENT  NO. 5 TO LOAN  AGREEMENT.  This Note is issued in connection
with  Amendment No. 5 to Loan Agreement of even date herewith by and between the
Borrower and the Bank, the terms of which are  incorporated  herein by reference
("AMENDMENT  No. 5"), and is secured by the  property  described in the Security
Agreement  by and between  the  Borrower  and the Bank and other loan  documents
entered into in connection with the Loan Agreement (the "LOAN DOCUMENTS") and by
such  other  collateral  as  previously  may have  been or may in the  future be
granted to the Bank to secure this Note.  The term "LOAN  AGREEMENT"  shall mean
the Loan  Agreement  dated as of May 6, 1999 by and between the Borrower and the
Bank,  as amended by  Amendment  No. 1 to Loan  Agreement  dated as of August 6,
1999, Amendment No. 2 to Loan Agreement dated as of November 30, 1999, Amendment
No. 3 to Loan  Agreement  dated as of February 7, 2000,  Amendment No. 4 to Loan
Agreement dated as of February 29, 2000 and Amendment No. 5.  Capitalized  terms
used herein  shall have the  meanings  provided in the Loan  Agreement  unless a
different meaning is provided herein.

     2. RATE OF INTEREST. Amounts outstanding under this Note will bear interest
at a rate per annum  determined in accordance with the Loan Agreement.  Interest
will be  calculated  on the basis of a year of 360 days for the actual number of
days in each interest period.

     3. PAYMENT TERMS.  Accrued interest will be due and payable on the 15th day
of each month,  beginning  with the payment due, if any, on July 15,  2000.  The
outstanding  principal  balance and any accrued by unpaid  interest shall be due
and payable on the Bridge Loan  Expiration  Date.  The "BRIDGE  LOAN  EXPIRATION
DATE" shall mean the earlier to occur of: (i) December 19, 2000 and (ii) closing
date of an initial  public  offering of any capital stock of the Borrower or any
other equity event whereby any holder or holders of the Borrower's capital stock
infuse(s)  additional  assets,  where cash or non-cash,  to Borrower either as a
contribution  of  capital,  a loan or  otherwise  of at  least  $3,000,000.  The
Borrower  acknowledges  and  agrees  that in no event will the Bank be under any
obligation  to extend or renew the  Bridge  Loan or this Note  beyond the Bridge
Loan  Expiration  Date.  If any  payment  under this Note shall  become due on a
Saturday,  Sunday  or  public  holiday  under  the laws of the  Commonwealth  of
Pennsylvania, such payment shall be made on the next succeeding business day and
such  extension  of time shall be included in computing  interest in  connection
with such  payment.  The  Borrower  hereby  authorizes  the Bank to  charge  the
Borrower's  deposit  account  at the Bank for any  payment  when due  hereunder.
Payments received will be applied to charges, fees and expenses (including

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attorney's  fees),  accrued  interest  and  principal in any order that Bank may
choose, in its sold discretion.

     4. DEFAULT. The occurrence of any one or more of the following events shall
constitute a "DEFAULT":

        (a) the  Borrower  shall fail to pay all or any portion of  principal on
this Note when due or any payment of  interest  within  five (5)  business  days
following the date when due; or

        (b) an Event of Default  shall occur under the Loan  Agreement  or other
Loan Documents.

Upon occurrence of a Default, the entire outstanding principal balance, together
with all interest, costs, charges and other amounts outstanding under this Note,
shall  become  immediately  due and payable  and,  upon such  acceleration,  all
amounts due hereunder shall bear interest at the Default Rate (defined below).

     5. LATE  PAYMENTS:  DEFAULT RATE. If the Borrower fails to make any payment
of  principal  when due or any payment of interest  or other  amount  coming due
pursuant to the  provisions  of this Note within five (5)  business  days of the
date due and  payable,  the  Borrower  also shall pay to the Bank a late  charge
equal to the lesser of five  percent (5%) of the amount of such payment of $500.
Such five (5) day  period  shall not be  construed  in any way to extend the due
date of any  such  payment.  The late  charge  is  imposed  for the  purpose  of
defraying the Bank's  expenses  incident to the handling of delinquent  payments
and is in  addition  to,  and not in lieu of,  the  exercise  by the Bank of any
rights  and  remedies  hereunder,  under  the  other  Loan  Documents  or  under
applicable  law, and any fees and expenses of any agents or attorneys  which the
Bank may employ.  At the option of the Bank upon the occurrence of a Default and
during the  continuance  thereof,  this Note shall bear  interest  at a rate per
annum (based on a year of 360 days and actual days  elapsed)  which shall be two
percentage  points  (2%) in excess of the  interest  rate in effect from time to
time under this Note,  but not more than the  maximum  rate  allowed by law (the
"DEFAULT  RATE").  The  Default  Rate  shall  continue  to apply  whether or not
judgment shall be entered on this Note.

     6. PREPAYMENTS.  Mandatory Prepayments shall be made in accordance with the
terms of the Loan  Agreement.  The  indebtedness  evidenced  by this Note may be
voluntarily  prepaid in whole or in part at any time without  penalty or charge.
No amounts prepaid may be reborrowed.

     7. MISCELLANEOUS.  No delay or omission on the part of the Bank to exercise
any right or power arising  hereunder shall impair any such right or power or be
considered  to be a waiver  of any such  right or power,  nor  shall the  Bank's
action or inaction impair any such right or power. The Borrower agrees to pay on
demand,  to the extent permitted by law, all costs and expenses  incurred by the
Bank in the enforcement of its rights in this Note and in any security


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therefor,  including  without  limitation  reasonable  fees and  expenses of the
Bank's counsel. If any provision of this Note is found to be invalid by a court,
all the other provisions of this Note will remain in full force and effect.  The
Borrower and all other makers and  indorsers of this Note hereby  forever  waive
presentment, protest, notice of dishonor and notice of non-payment. The Borrower
also waives all defenses based on suretyship or impairment of collateral, except
for  such  impairment  which  results  from  the  gross  negligence  or  willful
misconduct of the Bank. This Note shall bind the Borrower and its successors and
assigns,  and the benefits hereof shall inure to the benefit of the Bank and its
successors and assigns.

     8.  GOVERNING  LAW.  This Note has been  delivered  to the Bank and will be
deemed  to be  made in the  Commonwealth  of  Pennsylvania.  This  Note  will be
interpreted  and the  rights  and  liabilities  of the  Bank  and  the  Borrower
determined in accordance with the laws of the Commonwealth of Pennsylvania.  The
Borrower hereby irrevocably consents to the exclusive  jurisdiction of any state
or federal court sitting in Allegheny  County,  Pennsylvania,  and consents that
all  service of  process  be sent by  nationally  recognized  overnight  courier
service directed to the Borrower at the Borrower's address set forth in the Loan
Agreement  and service so made will be deemed to be completed  when  received by
the Borrower; provided that nothing contained in this Note will prevent the Bank
from  bringing any action,  enforcing  any award or judgment or  exercising  any
rights  against the Borrower  individually,  against any security or against any
property of the  Borrower  within any other  county,  state or other  foreign or
domestic  jurisdiction.  The  Borrower  acknowledges  and agrees  that the venue
provided above is the most convenient  forum for both the Bank and the Borrower.
The Borrower  waives any  objection to venue and any  objection  based on a more
convenient forum in any action instituted under this Note.

     9. WAIVER OF JURY TRIAL. THE BORROWER IRREVOCABLY WAIVES ANY AND ALL RIGHTS
THE BORROWER MAY HAVE TO A TRIAL BY JURY IN ANY ACTION,  PROCEEDING  OR CLAIM OF
ANY NATURE RELATING TO THIS NOTE, ANY DOCUMENTS EXECUTED IN CONNECTION WITH THIS
NOTE OR ANY  TRANSACTION  CONTEMPLATED  IN ANY OF SUCH  DOCUMENTS.  THE BORROWER
ACKNOWLEDGES THAT THE FOREGOING WAIVER IS KNOWING AND VOLUNTARY.

     The  Borrower  acknowledges  that it has  read  and  understood  all of the
provisions of this Note, including waiver of jury trial, and has been advised by
counsel as necessary or appropriate.

                           [Signature Page to Follow]

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     WITNESS the due execution of this Note as a document  under seal, as of the
date first written above, with the intent to be legally bound hereby.


                                            INFORMAX, INC.


                                            By:  /s/ Alex Titomirov
                                                 -------------------------------

                                            Title:      CEO/Chair
                                                   -----------------------------

                                            Name:  Alex Titomirov
                                                   -----------------------------





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