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                                Date 1/1/2000                      Exhibit 10.17

                      INSTITUTE OF BONE AND JOINT RESEARCH
                           ROYAL NORTH SHORE HOSPITAL

                                     -and-

                            GEMINI RESEARCH LIMITED

          ------------------------------------------------------------
                      COLLABORATION AND LICENCE AGREEMENT
          ------------------------------------------------------------

               Confidential Treatment Requested and the Redacted
             Material has been separately filed with the Commission
<PAGE>

THIS COLLABORATION AND LICENCE AGREEMENT is made on _____________ 2000

BETWEEN:

(1)  INSTITUTE OF BONE AND JOINT RESEARCH, Royal North Shore Hospital St.
     Leonards, New South Wales, Australia 2065 (the "Institute"); and

(2)  GEMINI RESEARCH LIMITED, incorporated in England with company number 31003
     whose registered office is at 162 Science Park, Milton Road, Cambridge
     CB4 OGH ("Gemini").

WHEREAS:

(A)  Gemini is a biotechnology-based company whose principal objective is the
     discovery and characterisation of genes involved in certain common chronic
     diseases, including osteoporosis.

(B)  Gemini is desirous of retaining the services of the Institute and
     Investigator (as defined below) to assist Gemini both as a resource
     collaborator and in structuring and co-ordinating Gemini's programme
     involving initially musculo-skeletal diseases with the intention of
     extending the research into other disease areas.

(C)  The Institute has agreed to (i) procure that the Investigator will provide
     Gemini with the assistance referred to in (B), and (ii) grant Gemini and
     exclusive licence to use the Works.

(D)  The parties have agreed to enter into this Collaboration and Licence
     Agreement to regulate the arrangements referred to in Recitals (B) and (C).

NOW IS HEREBY AGREED

1.   DEFINITIONS

1.1  The expressions used in this Agreement shall have the following meanings:

     "Agreement" means this agreement and its attached Schedules, together with
     any letters or other agreements subsequently signed by both parties for the
     purpose of amending or modifying this agreement in accordance with its
     provisions for so doing.

     "Commencement Date" means 1st day of January 2000.

     "Confidential Information" means all information, data and experience of an
     operational, technical, business or scientific nature relating to the Works
     whether supplied to or obtained by the parties in written form, as a
     recording


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     or oral conversations and includes, without limitation, business secrets,
     trade secrets or any other information concerning the business, finances,
     any dealings, transactions or affairs of Gemini or the Gemini Group or any
     client, customer or supplier of Gemini or the Gemini Group whether supplied
     to or obtained by the parties in written form or as a recording or oral
     conversation, but excludes:

     (i)  information which is now or has become part of the public domain in
          other ways than by faults, acts or omissions of the parties; or

    (ii)  information which the parties can show was in their possession prior
          to the time of receipt from the other party; or

   (iii)  information which is now or has come lawfully into the possession of a
          party from and independent party who is entitled to divulge it and who
          is not under and obligation of confidentiality and in the case where
          the Institute is the recipient of the Confidential Information the
          supplier is neither the investigator nor a member of the Gemini Group.

     "Investigator" means Professor Philip Sambrook and employees of the
     Institute assisting him in the performance of the Institute's obligations
     under this Agreement.

     "the Works" shall mean all data, studies, reports, results and other
     information (including DNA) or inventions whether patentable or not
     produced or obtained by the Institute and the Investigator either
     individually or in conjunction with third parties or derived howsoever
     therefrom and which is funded or derived from funding provided by Gemini as
     envisaged in this Agreement in each case, including but not all limited to
     all abstracts, articles and other written materials relating to such
     research together with all modifications, improvements and amendments
     thereto.

     "Gemini Future Works" shall mean all data, studies, reports, result and
     other information (including DNA) or inventions whether patentable or not
     produced or obtained by Gemini as a result of any genotyping, phenotyping
     or other work carried out by any person other than the Institute or the
     Investigator on relation to or in connection with the Works which is not
     conducted at the Institute. This shall include, but not be limited to all
     abstracts, articles and other written materials relating to such genotyping
     and phenotyping together with all modifications, improvements and
     amendments thereto.

     "Gemini Group" shall mean Gemini and any company (i) which is a subsidiary
     company of Gemini or (ii) which is a holding company of Gemini, or (iii)
     which is a subsidiary of such holding company and "holding company" and
     "subsidiary company" shall have the meanings given to them by Section 9 of
     the Corporations Law (Commonwealth).

     "Licence" shall mean the licence granted by the Institute to Gemini under
     this Agreement in respect of the Works.


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     "Service Level Agreement" shall mean the Service Level Agreement between
     the Investigator and Gemini as attached in Schedule 1 to the Agreement and
     the Study Protocol referred to therein.

1.2  Words denoting the singular shall include the plural and vice versa; words
     denoting any gender shall include all genders; words denoting persons shall
     include corporations and vice versa.

1.3  Reference to any statute or statutory provision includes a reference to
     that statute or statutory provision includes a reference to that statute or
     statutory provision as from time to time amended, extended or re-enacted.

1.4  The headings in this Agreement are inserted for convenience only and shall
     not affect the construction hereof.

1.5  Unless otherwise stated a reference to a Clause or a Schedule is a
     reference to respectively a clause in or a schedule to this Agreement.

2.   APPOINTMENT

2.1  Gemini hereby appoints the Institute as its resource collection
     collaborator, during the term of this Agreement, to recruit individuals as
     provided in the Service Level Agreement.

3.   INVESTIGATOR

3.1  The Institute shall appoint the Investigator to co-ordinate Gemini
     programme relating to osteoporosis research including, without limitations,
     to:

     (a)  provide advice on the direction of Gemini's programme;

     (b)  to be responsible for co-ordinating and implementing the performance
          of the obligations of the Institute under Clause 2; and

     (c)  otherwise act on behalf of the Institute for the purpose of all
          dealings with Gemini arising under this Agreement.

4.   PERIOD OF APPOINTMENT, FEES AND GUARANTEE

4.1  The appointment shall commence on the Commencement Date and, subject to
     Clause 10 shall continue for an initial fixed period of two years expiring
     on the second anniversary of the Commencement Date. If Gemini wish to
     extend the appointment for a further year or subsequent years it shall give
     to the Institute not less than six months prior written notice.

4.2  Gemini shall pay fees as detailed in the Service Level Agreement.


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4.3  the Institute shall defray all other expenses of and incidental to the
     provision of its services under the Agreement.

5.   GRANT OF RIGHTS

5.1  The Institute hereby grants to Gemini an exclusive and perpetual worldwide
     licence to use, publish, comment on, sub-licence or otherwise deal in the
     Works on the terms set forth out in this Agreement.

5.2  The Institute and Gemini understand and agree that the Investigator may use
     the Works for any non-commercial research incidental to the performance of
     the duties of the Investigator in the Investigator's capacity as a
     scientist, but not otherwise. No other person within the Institute or
     otherwise shall be permitted to use the Works.

5.3  The Institute (through the Investigator) may publish the Works only with
     prior written consent of Gemini (such consent not to be unreasonably
     withheld) provided that, in each instance, (i) the Institute first provides
     Gemini with full copies of the Works desired to be published (including any
     abstracts or summaries) accompanied by a request to permit publication (the
     data upon which Gemini receives notice thereof, the "Request Date") and,
     (ii) if the consent of Gemini is not given within 4 weeks of the Request
     Date, the Institute may publish the Works in question without the consent
     of Gemini at any time following the expiry of the 3 month period commencing
     on the Request Date. Nothing in this Clause negates the exclusions listed
     on the definition of "Confidential Information" as they relate to the
     Works.

5.4  Forthwith upon execution of this Agreement the Institute shall keep the
     Works solely and exclusively to the order and or the benefit of Gemini
     pursuant to the terms of this Agreement. The Institute shall take all
     necessary action to safeguard the Works and shall supply Gemini with such
     copies of the Works which practically may be reproduced promptly at the
     reasonable request of Gemini made from time to time. The requirement for
     the Institute to maintain the samples on behalf of Gemini will be reviewed
     on the third anniversary of the Termination Date and each subsequent third
     anniversary date and continuance of storage will be evidenced by the
     written agreement of the parties.

5.5  Gemini shall be entitled to exploit the Works for its own purposes and the
     Institute undertakes to take all action necessary to enable Gemini to so
     exploit the Works including applying for patent or any such other
     protection as Gemini may require for all or any part of the Works at such
     times and in such manner as Gemini may require at Gemini's expense.

6.   CONFIDENTIALITY

6.1  Without prejudice to their respective common law rights and subject to
     Clause 5 of this Agreement, during the term of this Agreement and for a
     period of five years thereafter, the Institute undertakes:


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     (a)  to procure that the Investigator shall not except in the proper course
          of the Investigator's duties under this Agreement, use or disclose any
          Confidential Information.

     (b)  not to use or disclose Confidential Information except in the proper
          course of the performance of this Agreement by the Institute.

6.2  All notes, memoranda, records, tapes, discs, writings and designs of any
     member of the Gemini Group made or received by the Institute or the
     Investigator relating to the business of any member of the Gemini Group
     shall be and remain the property of the relevant member of the Gemini Group
     and shall be handed over by the Institute or the Investigator (as the case
     may be) to Gemini from time to time on demand and, in any event, upon the
     termination of the Appointment.

6.3  The Institute shall not and shall procure that the Investigator shall not
     at any time during or after the termination of the Appointment make or
     cause to be made untrue or misleading statement in relation to Gemini or
     any member of the Gemini Group nor, in particular, after the termination of
     the Appointment represent itself or himself (as the case may be) as being
     still connected with the Gemini Group.

7.   OTHER BUSINESS AND PUBLICATIONS

7.1  The Institute shall use its best endeavours to ensure that the Investigator
     shall not have a financial interest or advise or act as Investigator to any
     business or be involved in any other projects relating to osteoarthritis
     and osteoporosis, save for consultancies and projects and any renewals of
     such consultancies and projects in which the Investigator is already
     involved as at the date of this Agreement and which have been disclosed in
     writing to Gemini.

7.2  The Institute shall not and shall use its best endeavours to procure that
     the Investigator shall not knowingly enter into any research contracts with
     third parties conferring rights of commercial exploitation in or to the
     order or direction of such persons or undertake any research work sponsored
     by third parties conferring rights of commercial exploitation on or to the
     order or direction of such persons after the date if this Agreement which,
     in the case of the Investigator, compete or conflict with the interest of
     Gemini, and in the case of the Institute, involve or relate to the Works.

8.   PROVISION OF FACILITIES

8.1  The Institute shall provide the Investigator with full access to the Works
     and with all necessary facilities for the Investigator to enable the
     Institute to perform its duties hereunder.


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9.   WARRANTIES AND UNDERTAKINGS

9.1  The Institute undertakes, warrants and represents to Gemini in respect of
     itself and the Investigator, to the best of its knowledge having made all
     reasonable enquiries, that:

     (a)  the Works shall be the sole and original creation of the Institute and
          that it is and will be at all times the sole owner of all copyright
          and all other rights in the Works to this end where the Works have
          been created in conjunction with a third party (from whom the
          Institute has taken or will have taken prior to their creation an
          assignment of all rights the Investigator may have in the Future
          Works);

     (b)  neither the Institute nor the Investigator has granted a licence of
          the Works to any third party and that neither the Institute nor the
          Investigator has assigned all or any part of the same to a third
          party;

     (c)  the use of the Works and Gemini's use of the same will not infringe
          the rights of third parties;

     (d)  neither the Institute nor the Investigator has and shall have
          contractual or proprietary interest in the DNA samples;

     (e)  neither the Institute nor the Investigator has and shall have
          contractual proprietary interest in the Gemini Future Works;

     (f)  all samples recruited or referred to in the Service Level Agreement
          have and shall have no subsisting contractual or proprietary interest
          in data or materials collected on or provided by the team in
          accordance with this Agreement and the Service Level Agreement or
          waivers have been or will be obtained from all recruits which are
          expressed to waive any such rights.

     (g)  It has obtained and shall obtain all and any necessary ethical and
          medical approvals in connection with the performance of its
          obligations under this Agreement and the Service Level Agreement from
          all relevant authorities, and

     (h)  It has full authority to enter into this Agreement and perform all of
          the obligations hereunder and under the Service Level Agreement, and
          that the entry into, and performance by the Institute of, this
          Agreement does not and will not violate in any respect any law or
          regulation or any agreement to which it is a party.

9.2  Gemini warrants to the Institute that it has full authority to enter into
     and perform all of its obligations under this Agreement and the Service
     Level Agreement and that entry into and performance by Gemini of, this
     Agreement does not and will not violate in any respect any law or
     regulation binding on it.


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10.  TERMINATION

10.1 This Agreement shall commence on the Commencement Date and shall continue
     as envisaged in Clause 4 unless otherwise terminated in accordance with
     this Clause 10.

10.2 Either party may terminate this Agreement forthwith by sending a written
     notice to the other if:

     (a)  that other commits a material breach of its obligations under this
          Agreement and, in the case of a breach capable of remedy such breach
          is not remedied within 20 days of that other party being specifically
          required to do so:

     (b)  that other ceases to pay it debts or becomes insolvent within the
          meaning of section 922 of the Corporations Law (Commonwealth).

     WITHOUT PREJUDICE to the generality of the foregoing, the Institute shall
     be in material breach if the yearly number of individuals referred to in
     the Service Level Agreement is not collected in the relevant year; or the
     facilities provided by the Institute for the purpose of Clause 8.1 shall
     fail to be of a standard quality or undertake the Works efficiently.

10.3 Any termination of this Agreement shall be without prejudice to any rights
     for liabilities of the parties, which have accrued on or before the date of
     termination.

10.4 Any termination of this Agreement shall (subject to Clauses 10.5 and 10.6)
     have the following effect:

     (a)  Clauses 5.5, 6 and 9 shall remain in force and effect.

     (b)  Clause 5.3 shall terminate immediately;

     (c)  The License contained in Clause 5.1 shall become non-exclusive but
          shall otherwise continue in full force and effect; and

     (d)  any equipment provided by Gemini to the Institute shall be immediately
          delivered (at Gemini's cost) to such place(s) as Gemini may direct.

10.5 In the event that Gemini pursuant to Clause 10.2 terminates this Agreement
     the provisions of Clause 11 shall survive notwithstanding such termination.

10.6 In the event that this Agreement is terminated by the Institute pursuant to
     Clause 10.2 the provisions of Clause 11 shall not survive such termination
     and

     (a) all fees or expenses already paid to the Institute shall remain the
         property of the Institute and Gemini shall make no claim in respect
         thereof;


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<PAGE>

     (b)  Gemini shall pay to the Institute all fees due and unpaid as at the
          date of termination; and all outstanding salary commitments of the
          Institute to staff employed or engaged by the Institute for the
          purpose of performing the Institute's obligations under this agreement
          provided that the Institute shall use its best endeavours to reduce
          and mitigate those salary commitments including, if appropriate,
          terminating those employments or engagements.

11.  POST-TERMINATION COVENANTS

11.1 Within this Clause 11, the following words shall have the following
     meanings

     "Competitive Business" shall mean any business or activity carried on by
     Gemini or any Gemini Group at the Termination Date in which the
     Investigator shall have been directly concerned at any time in the Contact
     Period;

     "Contact Period" shall mean the 12 month period ending with the Termination
     Date;

     "Customer Connection" shall mean any person, firm, company or other
     organisation who was at any time in the Contact Period a customer, licence
     or supplier of or otherwise connected to Gemini or any other Gemini Group;

     "Skilled Employee" shall mean any person who was;

     (i)  employed by Gemini or any other Gemini Group; or

     (ii) contracted to render services to Gemini or any other Gemini Group,

     in design, financial, technical or managerial work during the Contact
     Period and who was so engaged or contracted on the Termination Date:

     "Termination Date" shall mean the date of termination of the Institute's
     appointment under this Agreement; and

     "Territory" shall mean Australia, the United Kingdom and the United States
     of America.

11.2 The Institute shall procure that the Investigator shall not during the
     period of 12 months after the Termination Date, directly or indirectly,
     either on its or her own account or otherwise, canvas, solicit or carry on
     and business relating to the Works or the Future Works or the Gemini Future
     Works from any Customer Connection with whom the Investigator shall have
     had material dealings in the Contact Period in the course of her
     engagement.

11.3 The Institute shall not and shall procure that the Investigator shall not
     during the period of twelve months after the Termination Date:


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<PAGE>

     (a)  offer employment or an engagement to any Skilled Employee with whom it
          has had material dealings during the term of this Agreement; or

     (b)  directly or indirectly induce any Skilled Employee with whom it has
          had material dealings during the term of this Agreement to leave
          Gemini's employment (or the employment of the relevant Gemini Group,
          as the case may be) whether or not this would be a breach of contract
          on the part of the Skilled Employee.

11.4 The Institute shall not and shall procure that the Investigator shall not,
     during the period of 12 months after the Termination Date, carry on or be
     interested in Competitive Business in competition with Gemini in the
     Territory whether as principal, agent, director, partner, proprietor,
     employee or otherwise.

11.5 The Institute recognises that the covenants and restrictions contained in
     this Clause 11 are for the benefit of Gemini and any member of the Gemini
     Group carrying out, participating in or contributing to the Works, the
     Future Works and the Gemini Future Works

11.6 The restrictions contained in this Clause 11 are intended to be separate
     and severable. In the event that any of the said restrictions shall not be
     held void, but would be valid of part of the wording thereof were deleted,
     such restriction shall apply with such deletion as may be necessary to make
     it valid and effective.

12   NOTICES

12.1 Any notice, request or other document to be given under this Agreement
     shall be in writing and shall be deemed fully given:

     (a)  if left at or sent by (i) prepaid first class post or airmail or
          (ii) telex or (iii) facsimile transmission, or (iv) other means of
          telecommunication in permanent writing from to the address shown on
          the face hereto or to such other address and/or number as either party
          may by notice to the other expressly substitute thereof, and

     (b)  when in the ordinary course of the means of transmission, it would
          first received by the addressee in normal business hours.

12.2 In proving the giving of a notice it shall be sufficient to prove that the
     notice was left or that the envelope containing such notice was promptly
     addressed and despatched or, as the case may be, electronically
     acknowledged.


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<PAGE>

13   ANCILLARY PROVISIONS

13.1 Partnership

     Nothing in this Agreement shall create or be deemed to create or evince a
     partnership or the relationship of principal and agent or the relationship
     of employer and employee between the parties.

13.2 Assignment

     Neither party shall assign, encumber or dispose of any of its rights and
     obligations under this Agreement without the prior written consent of the
     other party which shall not be unreasonably withheld PROVIDED that Gemini
     shall at all times with notice to the Institute, be entitled to assign
     and/or transfer all of its rights and/or obligations under this Agreement
     to a Gemini Group Company.

13.3 Severability

     If any part of this Agreement is found by court or other competent
     authority to be invalid, unlawful or unenforceable then such part shall be
     severed from the remainder of this Agreement which shall continue to be
     valid and enforceable to the fullest extent permitted by law.

13.4 Waiver

     No delay or failure by either party to exercise any of its powers, rights
     or remedies under this Agreement shall operate as a waiver of them, nor
     shall any single or partial exercise of them. The remedies provided in this
     Agreement are cumulative and are not exclusive of any remedies provided by
     law.

13.5 Entire Agreement

     (a)  With the exception of the Service Level Agreement, this agreement
          supersedes any agreements made or existing between the parties before
          or simultaneously with this Agreement (all of which shall be deemed to
          have terminated by mutual consent with effect from the date of this
          Agreement) and constitutes the entire understanding between the
          parties in relation to the subject matter of this Agreement.

     (b)  Except as otherwise permitted by this Agreement, no change to its
          terms shall be effective unless it is in writing and signed by or on
          behalf of both parties.


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14   COVERING LAW AND JURISDICTION

14.1 This Agreement shall be governed by and interpreted in accordance with the
     law of New South Wales and the parties hereby submit to the jurisdiction of
     the courts and tribunals of New South Wales.

IN WITNESS whereof this Agreement has been executed as a deed and delivered by
the Institute and by Gemini upon the day and year first above written

Signed as a Deed and Delivered by        )
GEMINI RESEARCH LIMITED                  )  /s/ HY Christley
acting by:                               )___________________
                                          Director

                                          /s/ [ILLEGIBLE]
                                          ___________________
                                          Director

Signed as a Deed and Delivered by        )
INSTITUTE OF BONE AND JOINT              )
RESEARCH in the presence of:             )

Name:

Address:


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<PAGE>

                                   SCHEDULE 1

                            SERVICE LEVEL AGREEMENT

                                    BETWEEN

                           Professor Philip Sambrook
                      Institute of Bone and Joint Research
                           Royal North Shore Hospital

AND

                              Gemini Research Ltd.
                               162, Science Park
                                   Cambridge
                                    CB4 0GH


Dated:_____________________________


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<PAGE>

The Commencement date of this Agreement is the date when the Agreement is signed
by both the Investigator and Gemini Research Ltd.

The Agreement is between Gemini Research Ltd. of 162, Science Park, Cambridge,
CB4 0GH (hereinafter referred to as "Gemini")

                                      AND

Professor Philip Sambrook, Institute of Bone and Joint Research, Royal North
Shore Hospital, St. Leonards, NSW, Australia, 2065 (hereinafter referred to as
("Investigator").

WHEREAS:

(A)  The Investigator has agreed to collect research data involving twins for
     export to Gemini.

(B)  Gemini and Investigator have a separate contract that defines the level of
     this collaboration.

(C)  This Service Level Agreement relates to the study to be conducted by
     Investigator entitled: *

1.   DEFINITIONS

1.1  "Commencement date" is the date of commencement of the study in the
     Institution. The commencement date of the study is January 2000.

1.2  "Ethics Committee" means the Human Research Ethics Committee for the
     Institution which is responsible for approving the study protocol.

1.3  "Informed Consent Form" means the consent form to be completed by each
     subject.

1.4  "Institution" means the Institute of Bone and Joint Research, Royal North
     Shore Hospital.

1.5  "Subject Information Sheet" means the information sheet explaining the
     procedure and risks of the study.

1.6  "Study Protocol" means * and dated 15/10/99, including any subsequent
     amendments.

1.7  Words importing the singular includes plural and reference to one gender
     includes any gender.

1.8  Headings and underlinings are for convenience only and do not affect the
     interpretation of this Agreement.

2    TERM OF THIS AGREEMENT


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               Confidential Treatment Requested and the Redacted
             Material has been separately filed with the Commission
<PAGE>

2.1  This Agreement covers the period from commencement of the study, for a
     period of two years, or until * twins for the project worldwide, have been
     recruited, if this occurs earlier than the 2 year period.

3    OBLIGATIONS OF INVESTIGATOR

The Investigator agrees to:

*

(b)  Conduct the study in accordance with the protocol, Australian GCRP and ICH
     GCP guidelines, the requirements of the Ethics Committee and any reasonable
     conditions imposed by Gemini.

(c)  Obtain approval to conduct the study from the relevant Ethics Committee of
     the Institution and any other Ethics Committee required to provide ethical
     approval of the study.

(d)  Ensure all Institutional staff members involved in the study are fully
     informed of the protocol and the obligations of the Institution and
     Investigator.

(e)  Obtain from each subject freely given written informed consent prior to
     commencement of any study procedures. Provide to the subject a copy of the
     approved subject information sheet and signed informed consent form.

(f)  Collect accurate data and maintain complete and up to date records during
     the study, including questionnaires, test results, all study related
     correspondence by the investigator and staff.


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               Confidential Treatment Requested and the Redacted
             Material has been separately filed with the Commission
<PAGE>

(g)  Provide results of medical tests, as appropriate to the subjects, or their
     nominated GP. A copy of the correspondence will be kept on file. All
     queries about medical issues will be referred to the Investigator.

(h)  Ensure only accredited laboratory facilities are used for timely
     measurement of laboratory parameters as outlined in the study protocol.

(i)  Store laboratory samples according to Gemini procedures. Maintain a log of
     all samples stored for the study. Shipment of samples to Gemini will be
     undertaken according to Gemini procedures.

(j)  Undertake DNA extraction according to Gemini procedures and maintain a
     suitable log of samples stored and shipped to Gemini.

(k)  Obtain written approval from the Ethics Committee for any advertisement to
     be used for the purposes of subject recruitment prior to placement of the
     advertisement.

(l)  Comply with all applicable laws, statutes, ordinances and regulatory
     requirements in Australia relating to the conduct of the study and all
     relevant laws and regulations governing the protection and privacy of
     personal data.

(m)  Not to transfer the study to another institution without first consulting
     with Gemini.

(n)  Ensure the Institution has the necessary facilities and staff to conduct
     the study and that they will be maintained for the duration of the study.

(o)  Conduct the tests required by the protocol, and the questionnaires in
     accordance with Gemini procedures. Data collection will be completed within
     one week of the subject visit and made ready for Gemini review.

(p)  Maintain subject files to include signed consent form, subject contact
     details and respective twin details, completed questionnaire, preliminary
     questionnaire completed by the subject, source document form, results of
     all tests and procedures and completed data query forms.

(q)  Export data to Gemini on a monthly basis, according to Gemini procedures.
     Data transfer includes electronic transfer of tests results as well as hard
     copy transfer of questionnaires and tests results as agreed with Gemini.

(r)  Cooperate with Gemini or any person nominated by Gemini in monitoring and
     supervising the conduct of the study and ensure access to any records
     related to the study.

(s)  Maintain all study related records for a period of 15 years after
     termination of the study.

(t)  If required, allow access to the study related records by Gemini, or its
     agents, or any Health Authority, for audit, inspection or examination of
     the


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<PAGE>
     records or facilities of the Institution. Such audit may be undertaken
     after the termination of this Agreement.

4.   OBLIGATIONS OF GEMINI

(a)  Provide advice and information as required to the Investigator and staff on
     the study.

(b)  Provide detailed information on Gemini procedures that are required by the
     Institution to conduct the study.

(c)  Monitor and supervise the conduct of the study and ensure adequate
     understanding of Gemini procedures and requirements with regard to the
     study protocol, data recording and data collection procedures.

(d)  Keep accurate records of subject visits, test conducted and payments due.

5.   STUDY PAYMENT

5.1  Gemini agrees to pay the Investigator a maximum of * for the study for
     the 2 year period 2000 - 2001, subject to clause 5.2 below. The fees are
     split into *.

5.2  * Costs for 2001 are subject to satisfactory performance as specified in
     this agreement, especially in relation to subject recruitment and data
     collection and quality. If the performance target is not achieved in the
     year 2000, the * component of the budget for the year 2001 will be
     re-negotiated.

5.2  * and * fees are listed in Appendix A to this Agreement and are
     duplicated in the tables below. Tests not listed in the table are to be
     performed by the research staff without any additional charge.

                                       *

                                       17

               Confidential Treatment Requested and the Redacted
             Material has been separately filed with the Commission
<PAGE>

                                       *

     The schedule of payment will be as follows:

     (i)   * for the year 2000 will be payable on signing of this Agreement.

     (ii)  * will be paid on a monthly basis, one month in advance. The
           monthly fee for * in 2000 will be *. The monthly fee for * in
           2001 will be *.

     (iii) * will be paid on work completed. Hence only those * will be
           re-imbursed. Payments will be calculated on data transferred
           to Gemini and payable quarterly, in March, June, September
           and December of each year.

     (iv)  *.

5.3  Payments will not be made for subjects recruited into the study who are
     ineligible (do not meet the inclusion/exclusion criteria).

5.4  *

5.5  Costs for shipment of data and study samples to Gemini will be charged
     directly to a Gemini Account, as agreed separately.

6.   TERMINATION

                                       18

               Confidential Treatment Requested and the Redacted
             Material has been separately filed with the Commission
<PAGE>

6.1  Either party shall be entitled to immediately terminate this Agreement at
     any time by notice in writing to the other party if the following event
     occur.

     (a)  if a party should commit a breach of this Agreement and should fail to
          be unable to remedy the breach within 30 days of receipt of notice
          specifying the breach:

     (b)  if a party goes into liquidation or a provisional liquidator is
          appointed to it;

     (c)  if a party commits an act of bankruptcy

     (d)  if a party is wound up

7.   GEMINI'S ADDITIONAL RIGHT TO TERMINATE

In addition to the rights of the parties to terminate this Agreement pursuant to
Clause 6, Gemini shall have additional right to immediately terminate this
Agreement on written notice to the Investigator if:

     (a)  Gemini should wish to discontinue the study for commercial reason.

     (b)  If Gemini had reason to believe the study could not be satisfactorily
          completed, including, but not limited to inadequate numbers of twins.

8.   OBLIGATIONS OF THE INVESTIGATOR UPON TERMINATION OF THIS AGREEMENT

On termination of this Agreement for any reason whatsoever, the Investigator
shall:

(a)  deliver to Gemini all study data, including hard copy and electronic data
     which are in the possession of the Investigator at the time of termination.

(b)  co-operate with Gemini with a view to bringing about an orderly termination
     of the study in the Institution

(c)  receive all outstanding monies for work done at the date of termination.

9.   OBLIGATIONS OF GEMINI UPON TERMINATION OF THIS AGREEMENT

On termination of this Agreement Gemini shall:

(a)  pay or ensure payment to the Investigator of all monies owing as as date of
     termination of this Agreement

(b)  assist the Investigator and the Institution in an orderly termination of
     the study.

10.  OWNERSHIP OF DATA


                                       19
<PAGE>

The Investigator acknowledges and agrees that all rights title and interest to
the data, results and any materials supplied by Gemini to the Investigator in
connection with this study, are the exclusive property of Gemini, together with
any rights and interest to any intervention and all information arising out of
the study. The Investigator will not acquire any intellectual property rights as
a result of this study. The data will be collected by Gemini and exported to the
UK.

11.  GOVERNING LAW

This Agreement will be governed and constructed in accordance with the laws of
the NSW, Australia.

12.  ASSIGNMENT

This Agreement is between the Gemini and the Investigator and neither shall
sell, assign or transfer any duties, rights or interests created under this
Agreement without prior written consent of the other.

13.  ENTIRE AGREEMENT

This Agreement superceded all prior Agreements, arrangements and undertakings
between the parties relating to the matters recited in this Agreement and
constitutes the entire Agreement between the parties.

14.  NOTICES

Any notice, demand, consent or other communication under this Agreement must be
addressed to the parties as follows:

(a)  Dr. Howard Christley
     Gemini Research Ltd
     162, Science Park
     Cambridge CB4 0GH
     Tel: 44 1223 435332
     Fax: 44 1223 435301

(b)  Professor Philip Sambrook
     Institute of Bone and Joint Research
     Level 4, Block 4
     Royal North Shore Hospital
     St Leonards NSW 2065
     Tel: 61 2 9926 7281
     Fax: 61 2 9906 1859


                                       20
<PAGE>

IN WITNESS whereof this Agreement has been executed by and on behalf of the
Parties:

By:  Dr Howard Christley
     Signed:____________________
     Chief Medical Officer,
     For and on behalf of
     Gemini Research Ltd
     Date:_____________________


By:  Professor Philip Sambrook


     Signed:/s/Philip Sabrook
           --------------------
     Institute of Bone and Joint Research
     Royal North Shore Hospital


                                       Date:  1/1/2000
                                            ---------------------


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