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                                                                   Exhibit 10.13

                          MARKETING ALLIANCE AGREEMENT

      This Marketing Alliance Agreement (this "Agreement") is made and dated as
of December 1, 1998 between QUINTILES TRANSNATIONAL CORP., a North Carolina
corporation ("Quintiles"), and VARIAGENICS, INC., a Delaware corporation
("Variagenics").

      WHEREAS, Quintiles is in the business of providing contract pharmaceutical
services, including Clinical Services (as defined below);

      WHEREAS, Variagenics is in the business of providing pharmacogenomic
technologies and services, including Variagenics Services, Variagenics Gene
Rights and Variagenics Technology (as defined below);

      WHEREAS, the parties desire to establish an alliance to enable the
marketing and delivery of Variagenics Services, Variagenics Gene Rights and
Variagenics Technology through and on an integrated basis with Quintiles'
Clinical Services to Sponsors on the terms and conditions in this Agreement (the
"Alliance");

      NOW, THEREFORE, in consideration of the mutual promises and covenants of
the parties set forth in this Agreement, Quintiles and Variagenics agree as
follows:

      1.    DEFINITIONS.

      As used in this Agreement, the following terms shall have the following
meanings:

      "Alliance Agreement" shall mean a written agreement with a Sponsor
pursuant to which an Alliance Program is conducted.

      "Alliance Program" shall mean (i) any contract preclinical or clinical
research program or other program for a Sponsor for which Quintiles and
Variagenics make a proposal hereunder during the conduct of which Variagenics
provides Variagenics Services or in which Variagenics

Portions of this Exhibit were omitted and have been filed separately with the
Secretary of the Commission pursuant to the Company's application requesting
confidential treatment under Rule 406 of the Securities Act.
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or the Sponsor (under license from Variagenics) utilizes Variagenics Gene
Rights, and in which Quintiles provides other services (directly or indirectly)
to the Sponsor and (ii) any contract preclinical or clinical research program or
other program for a Sponsor for which Quintiles and Variagenics make a proposal
hereunder and during the conduct of which Variagenics provides Variagenics
Services or in which Variagenics or the Sponsor (under license from Variagenics)
utilizes Variagenics Gene Rights, and in which Quintiles does not provide other
services (directly or indirectly) to the Sponsor. Alliance Programs will not
include drug discovery or gene discovery alliances or other corporate alliances
not involving CROs (including Quintiles) in which Variagenics participates.

      "CR0" shall mean a contract research organization.

      "Clinical Services" shall mean clinical trial management, monitoring, data
management, biostatistics, medical, regulatory and other related services
performed under contract for an entity which is testing a pharmaceutical product
for the purpose of obtaining either regulatory approval to conduct human
clinical trials or regulatory approval of the sale of such product. Clinical
Services does not include (i) basic research and development activities in drug
discovery, or (ii) diagnostic laboratory services.

      "Event of Default" shall have the meaning given such term in Section
12(h).

      "Field" shall mean products and services regarding the effects of gene
sequence variation on drug action, including pharmacokinetics and
pharmacodynamics.

      "Joint Alliance Program" shall mean an Alliance Program described in
clause (i) of the definition of Alliance Program.

      "Note" shall have the meaning given such term in Section 12.


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      "Quintiles Technology" shall mean all processes, know-how, trade secrets,
analytical methods, procedures, techniques, technical expertise, computer
software, algorithms and other intellectual property for use in conducting,
monitoring and analyzing data from clinical trials, which are owned or licensed
by Quintiles.

      "Senior Debt" shall mean all indebtedness of Variagenics for borrowed
money from banks and similar institutional lenders and all liabilities under
equipment and real estate lease.

      "Sponsor" shall mean a pharmaceutical, biotechnology or drug development
company or similar entity, which contracts for an Alliance Program.

      "Termination Date" shall have the meaning given such term in Section 6.

      "Unilateral Alliance Program" shall mean an Alliance Program described in
clause (ii) of the definition of Alliance Program.

      "Variagenics Gene Rights" shall mean all proprietary gene-sequence
variances (each, a "Variance") and variance databases (each, a "Variance
Database") useful in demonstrating the effect of gene sequence variance on drug
action, which are owned or licensed by Variagenics.

      "Variagenics Services" shall mean all services offered or rendered from
time to time by Variagenics pursuant to Section 3(c)(ii) and (iii).

      "Variagenics Technology" shall mean (i) all variance discovery
technologies, variance detection technologies, proprietary pharmacogenomics
algorithms, applications and procedures, useful in demonstrating the effect of
gene sequence variance on drug action, which are owned or licensed by
Variagenics, and (ii) Variagenics Gene Rights.

      2.    ESTABLISHMENT OF THE ALLIANCE.


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      (a) Purpose of the Alliance. The purpose of the Alliance is to enable the
marketing and delivery of Variagenics Services, Variagenics Gene Rights and
Variagenics Technology through and on an integrated basis with Quintiles'
Clinical Services to Sponsors. The goal of the Alliance is to engage in multiple
Alliance Programs, during which Sponsors will use Variagenics Gene Rights and
Variagenics Services in clinical development programs performed by Quintiles in
order to facilitate development, approval and marketing of such Sponsors'
products. Depending on the particular circumstances and requirements of each
Alliance Program, Quintiles and Variagenics will make these technologies and
services available to Sponsors through (a) Variagenics Services rendered by
Variagenics or (b) licensing Variagenics Gene Rights to Sponsors.

      (b) Management of the Alliance.

            (i) Joint Management Committee. Within 30 days following the date of
this Agreement, the parties shall form a standing joint management committee
(the "Joint Management Committee") which shall (i) manage the Alliance, (ii)
generally oversee the performance of the parties under this Agreement; (iii)
plan, schedule and coordinate Joint Alliance Programs, (iv) provide continuity
for making strategic decisions relating to the Alliance and this Agreement, and
(v) to develop appropriate operating procedures for the Alliance and Affiance
Programs. The Joint Management Committee shall be comprised of four members, two
of whom shall be appointed by Quintiles and two of whom shall be appointed by
Variagenics. The Joint Management Committee shall meet at least quarterly (or
less frequently by agreement of its members). The party which appointed a member
of the Joint Management Committee may (or shall, in the event of a vacancy)
appoint a replacement for such member at any time, in such party's sole
discretion, effective upon written notice to the other party.


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            (ii) Project Teams. At the time that each Joint Alliance Program is
initiated by Quintiles and Variagenics, the parties will create a project team
for such Joint Alliance Program (which may be the same team for one or more
programs), which shall coordinate with the Joint Management Committee on matters
relating to such Joint Alliance Program. Each party will use its reasonable
efforts to afford access to such party's project team by the other party's
project team for each Joint Alliance Program, including with respect to
participation in internal and Sponsor project team meetings and planning and
decision processes, in order to assure optimal project coordination and
implementation.

      (c) Relationship of the Parties.

            (i) Quintiles intends that during the term of this Agreement,
Quintiles will treat Variagenics as Quintiles' preferred provider of products
and services within the Field, on a worldwide basis. Variagenics intends that
during the term of this Agreement, Variagenics will treat Quintiles as
Variagenics' preferred provider for Clinical Services to Variagenics or
Variagenics' clients, on a worldwide basis. Each of the parties intends that
during the term of this Agreement the parties will collaborate to provide the
parties with significant marketing opportunities under Alliance Programs. For
purposes of this Agreement, "preferred provider' means that a party will give
first and preferential consideration to the other party when such party intends
to market (or make proposals to a prospective Sponsor to provide) Clinical
Services in combination with services or technology substantially similar to
those of Variagenics, with a view towards fulfilling the purpose of the Alliance
as set forth above, subject to the terms and conditions of this Agreement.

            (ii) Each party acknowledges that, in order to properly serve their
clients, they must maintain existing third party relationships and continue to
develop new third party


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relationships. Therefore, consistent with the provisions hereof, the Alliance
and relationship contemplated herein shall not be considered an exclusive
relationship, except that until December 31, 2000 (a) Variagenics shall market
(or make proposals to a prospective Sponsor to provide) Variagenics Gene Rights
or Variagenics Services in the Field in combination with the provision of
Clinical Services exclusively with Quintiles and (b) Quintiles shall market (or
make proposals to a prospective Sponsor to provide) Clinical Services in
combination with rights to gene variances or gene variance databases or
provision of services in the Field substantially similar to the Variagenics
Services exclusively with Variagenics. The foregoing will not restrict
Variagenics from providing products and services in the Field to companies
directly, whether such companies conduct clinical trials themselves or with a
CRO, nor will it restrict Quintiles from providing contract clinical trial
services to any companies, whether such companies obtain services in the Field
from another supplier of such services or such companies do work in the Field
themselves.

            (iii) Without limiting the foregoing, Variagenics understands that
Quintiles may direct services in the Field to other providers, based upon lack
of capacity of Variagenics, business conflicts resulting from Variagenics'
relationships with developers of competing drugs, the unavailability to Alliance
Programs of Variagenics Gene Rights necessary to complete a proposed Alliance
Program as a result of a license by Variagenics of such Variagenics Gene Rights
to a third party, the unavailability to Variagenics of intellectual property
necessary to complete a proposed Alliance Program, Sponsor preferences, and
extreme variances in costs.

            (iv) Any complaints regarding a party's utilization of the other
party's services shall be referred to the Joint Management Committee. In the
event that a Sponsor objects to using either party as a provider of services
under an Alliance Program because of an actual or


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potential business conflict between such party and such Sponsor, the matter
shall be referred to the Joint Management Committee.

            (v) Except as expressly provided in this Agreement, nothing will
constitute either party as agent for the other or give either party the
authority to make representations or agreements on behalf of the other, and each
party covenants not to make any representations or to take any actions
inconsistent with the foregoing. The parties are independent contractors and
nothing in this Agreement will be deemed to constitute or create a joint
venture, partnership, pooling arrangement, principal and agent arrangement or
other formal business entity or fiduciary relationship between the parties.

            (vi) In carrying out its responsibilities under this Agreement, each
party agrees that its activities will be conducted in compliance with all
applicable laws, rules and regulations, including the U.S. Food, Drug and
Cosmetic Act and the regulations promulgated pursuant to such Act, or any
equivalent laws, rules or regulations pertaining to jurisdictions in which the
activities are conducted. Neither party will engage the services of any person
debarred by relevant governmental or regulatory authorities, in connection with
activities under this Agreement.

      3.    MARKETING AND ADMINISTRATION OF ALLIANCE PROGRAMS

            (a) Marketing Plan for Alliance Programs. Within 30 days following
the date of this Agreement, Quintiles shall use its reasonable efforts to
prepare for the parties an initial plan for marketing Alliance Programs under a
written marketing plan (a "Marketing Plan"). Quintiles shall consult with
Variagenics in preparing a Marketing Plan and it shall be subject to
Variagenics' approval, which Variagenics shall not withhold unreasonably. The
initial Marketing Plan (and all subsequent Marketing Plans) adopted by the
parties shall be executed by the parties


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and become a part of this Agreement. A Marketing Plan adopted by Quintiles and
Variagenics may be modified from time to time by written agreement of the
parties. At least annually, the parties will adopt a Marketing Plan for the
coming year, and a Marketing Plan shall remain in effect until a subsequent
Marketing Plan is adopted by the parties in writing or until the earlier
termination of this Agreement. Each Marketing Plan will:

                  (i) identify possible business opportunities for Alliance
Programs, including identification and prioritizing of target Sponsors;

                  (ii) set forth the responsibilities of each party with respect
to such business opportunities and the development of such business
opportunities;

                  (iii) set forth a marketing and sales strategy;

                  (iv) establish a budget;

                  (v) establish minimum commitments of resources by each party
in order to assure proper sales force staffing and training, marketing material
development, conference presentation and public relations, target Sponsor
identification and prioritization, and sales call strategy development and
implementation (which shall include at least two FTE's from Quintiles and one
FTE from Variagenics); and

                  (vi) require that any marketing materials for prospective
Alliance Programs used repetitively by either party relating to the conduct of
clinical trials involving the Field will be approved by both parties and will
include the names and logos of both parties and state that Quintiles will
provide Clinical Services and that Variagenics will provide Variagenics Services
and Variagenics Gene Rights.

            (b) Procedure for Proposals to Sponsors for Alliance Programs.


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                  (i) Quintiles will coordinate the marketing of Alliance
Programs, including the marketing of Variagenics Technologies and Variagenics
Services directly to Sponsors, as part of Quintiles' portfolio of Clinical
Services, and Variagenics will provide its technologies and services and commit
its capacity to Alliance Programs, all subject to the terms and conditions of
this Agreement. Quintiles will coordinate proposals for Alliance Programs and
lead negotiations with Sponsors for corresponding Alliance Agreements. Such
Alliance Agreements shall be between Quintiles and the Sponsors, unless
otherwise agreed by Quintiles, except that licenses for Variagenics Gene Rights
will be between Variagenics and the Sponsor.

                  (ii) Within 30 days following the date of this Agreement,
Quintiles shall use its reasonable efforts to prepare for the parties a formal,
written process for preparing and presenting proposals to Sponsors for Alliance
Programs (a "Proposal Plan"), which the parties agree will be established
consistent with existing and future processes in place at Quintiles. Quintiles
shall consult with Variagenics in preparing a Proposal Plan and it shall be
subject to Variagenics' approval, which Variagenics shall not withhold
unreasonably. The initial Proposal Plan (and all subsequent Proposal Plans)
adopted by the parties shall be executed by the parties and become a part of
this Agreement. A Proposal Plan adopted by Quintiles and Variagenics may be
modified from time to time by written agreement of the parties.

                  (iii) Set forth on Exhibit A are "per unit" prices for certain
non-exclusive licenses and services, which the parties agree shall be minimum
prices applicable to Alliance Programs. Also set forth on Exhibit A is a
description of the payment terms, including timing of payments by Sponsors,
which the parties agree shall be applicable to Alliance Programs. All
information set forth on Exhibit A is collectively referred to in this Agreement
as the "Pricing Schedule." At least annually, the parties will review the
Pricing Schedule to consider whether


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adjustments are necessary to reflect market conditions. The Pricing Schedule may
be modified from time to time by written agreement of the parties. The Pricing
Schedule shall remain in effect until modified by the parties or until the
earlier termination of this Agreement.

                  (iv) Whenever Quintiles identifies an opportunity for an
Alliance Program, which in Quintiles' reasonable judgment should be pursued,
Quintiles shall notify Variagenics of a proposed Alliance Program. Promptly
following such notification, the parties agree to cooperate in good faith to
establish a proposal for presentation to the respective Sponsor. Quintiles shall
consult with Variagenics in preparing such proposal and it shall be subject to
Variagenics' approval, which Variagenics shall not withhold unreasonably.
Specifically, Variagenics agrees that it will not withhold its approval on a
proposal as to pricing the Alliance Program, so long as the terms of the
Alliance Program meet or exceed the terms set forth on the Pricing Schedule. A
proposal as finally adopted by Quintiles and Variagenics may be modified from
time to time by written agreement of the parties.

                  (v) The parties acknowledge and agree that they contemplate
that Variagenics will participate at the request of Quintiles in a proposed
Alliance Program, for which the Applicable Percentage for Advances under Section
12 is 80%, unless Variagenics is restricted from doing so due to contractual
commitments of Variagenics to third parties, including licenses by Variagenics
of Variagenics Gene Rights. Variagenics will be free to participate or not, in
its sole discretion, in any other proposed Alliance Program. Variagenics agrees
to notify Quintiles in writing from time to time of such commitments, promptly
after such commitments are incurred. At the request of Quintiles, Variagenics
will participate in good faith in the presentation to a Sponsor of any proposal
adopted by the parties for an Alliance Program.


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            (c) Services and Rights to be Provided to Sponsors Under Alliance
Programs. In connection with Alliance Programs, the parties will provide the
services and take the other actions as described in this Section, subject to the
other terms and conditions of this Agreement.

                  (i) General. Depending on the particular circumstances and
requirements of each Alliance Program, Quintiles and Variagenics will make
Variagenics' technologies and services available to Sponsors through (a)
Variagenics' Services rendered by Variagenics to a Sponsor, pursuant to an
Alliance Agreement between Quintiles and the Sponsor and pursuant to this
Agreement or (b) licensing Variagenics Gene Rights to Sponsors, pursuant to a
license agreement between Variagenics and the Sponsor.

                  (ii) Services to be Provided by Variagenics.

                        (A) Variance Discovery and Database: Variagenics will
perform variance discovery in specified genes under Alliance Programs.
Variagenics will select candidate genes which may affect drug action,
pharmacokinetics, or pharmacodynamics and provide the Sponsor with an annotated
summary of variances in the Variance Database, Variances discovered by
Variagenics, or variances in the public domain. Variance discovery in genes
proprietary to Sponsors will be performed by Variagenics outside the Alliance.

                        (B) Variance Detection: Variagenics will perform or
engage contractors to perform Variance Detection for Alliance Programs using
Variagenics Technologies. The parties will discuss during the first year of this
Agreement (at any time until Variagenics has engaged a contractor to perform
Variance Detection) the feasibility, terms and conditions of transferring the
Variance Detection Technology to Quintiles to enable Quintiles to perform
Variance Detection, in which event Quintiles could elect to be a preferred
provider to Variagenics' partners for Variance Detection in clinical trials
outside Alliance Programs.


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<PAGE>

                        (C) Pharmacogenomic Services: Variagenics will provide
pharmacogenomic services, such as genetics, pharmacogenomic statistics,
pharmacology, medicinal chemistry, molecular modeling and simulation, commercial
modeling, pharmacogenomic sub-protocol writing, data management, biostatistics,
pharmacogenomic analyses and report writing, for Alliance Programs.

                  (iii) Other Commitments of Variagenics.

                        (A) Variance Use Rights: Variagenics will provide
Variance Database access to Sponsors and grant non-exclusive licenses (or
options to obtain non-exclusive licenses) to use Variances in selected genes to
Sponsors for use in Alliance Programs on terms coordinated by Quintiles and
Variagenics as part of each corresponding Alliance Program proposal, which shall
be no less favorable than the terms upon which similar non-exclusive licenses or
options are made available to Variagenics' clients outside the Alliance. Once a
Sponsor has use rights for any Variances, Variagenics will not grant rights to
third parties which will limit or terminate the Sponsor's rights. Variagenics
shall control the grant of exclusive or co-exclusive licenses to Variances and
shall give notice of the availability of such rights to Sponsors, and they shall
be made available on terms no less favorable than they are made available to
Variagenics' clients outside the Alliance.

                        (B) Preferred Provider for Programs Outside Alliance:
Variagenics will use reasonable efforts to have the Alliance be the preferred
provider for Clinical Services in the Field for any clinical trial program
outside the Alliance in which Variagenics participates.

                  (iv) Services to be Provided by Quintiles.


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                        Quintiles (including its affiliates) will perform
contract clinical research services, such as clinical trial management,
monitoring, data management, biostatistics, medical, regulatory, and other
related services for Joint Alliance Programs.

            (d) Certain Responsibilities of Each Party.

                  (i) Each party will reserve sufficient capacity and resources
for proposed Alliance Programs which are accepted by Sponsors, so that each such
Alliance Program may be implemented and completed on a timely basis in
accordance with the terms of the respective proposal adopted by the parties.

                  (ii) Each party will cooperate and negotiate in good faith
regarding all Marketing Plans, Proposal Plans, Pricing Schedules, proposals for
Alliance Programs, and other matters relating to this Agreement.

                  (iii) Each party will use reasonable efforts to implement all
Marketing Plans and Alliance Programs adopted by the parties and accepted by
Sponsors.

                  (iv) Except as otherwise agreed in writing by the parties,
each party shall be solely responsible for all costs and expenses incurred by it
in preparing proposals for Alliance Programs and in providing services under
Alliance Programs.

            (e) Compensation and Payments.

                  (i) Quintiles shall bill Sponsors for all payments due
under Joint Alliance Programs, and revenues remitted by Sponsors thereunder
shall be paid to Quintiles. After receipt of such revenues from a Sponsor,
Quintiles shall remit to Variagenics as soon as practical 95% of the revenues
which are attributable to Variagenics Services rendered by

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Variagenics under Joint Alliance Programs, less any amounts applied to Advances
or otherwise as provided in Section 12 below.

                  (ii) Variagenics shall bill Sponsors for all payments due
under Unilateral Alliance Programs, and revenue remitted by Sponsors thereunder
shall be paid to Variagenics. After receipt of such revenues from a Sponsor,
Variagenics shall remit to Quintiles as soon as practical a commission equal to
[      ]% of revenues received under Unilateral Alliance Programs.

                  (iii) Each party shall keep reasonably detailed records of all
revenues received under Alliance Programs, which shall be available for
inspection by the other party, upon reasonable advance notice.

            (f) Alliance Brands.

                  (i) Any trademarks, service marks or other relevant brand
names (collectively, "Brands") created, registered or used in relation to
marketing of Alliance Programs under this Agreement will be agreed upon by both
parties. Quintiles will be responsible for maintaining any registrations related
to these Brands, except as such Brands relate solely to Variagenics
Technologies, Variagenics Services or Variagenics Gene Rights, and the expenses
associated with maintaining such registrations shall borne equally by the
parties.

      4. License from Variagenics to Quintiles.

            (a) To the extent necessary to permit Quintiles to perform Clinical
Services under any Joint Alliance Program, Variagenics hereby grants to
Quintiles a worldwide, nonexclusive license under all Variagenics Technology
(other than Variagenics Gene Rights) and a worldwide, non-exclusive sublicense
under all licenses of Variagenics Technology to


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Variagenics to use Variagenics Technology (other than Variagenics Gene Rights)
solely to perform Clinical Services for Sponsors in Joint Alliance Programs.
Such license and sublicense shall become effective for each Joint Alliance
Program upon execution of the Alliance Agreement with respect thereto and shall
terminate on the Termination Date with respect to such Joint Alliance Program.
Quintiles will not have the right to sublicense Variagenics Technology. In the
event that Variagenics owns or otherwise controls any technology during the term
of the Agreement that is reasonably required to practice Variagenics Technology
licensed to Quintiles in any Joint Alliance Program, then Variagenics will use
reasonable efforts to license or sublicense, as the case may be, such technology
to Quintiles, to the extent Variagenics has a legal right to do so.

            (b) After the date hereof, upon request by Quintiles, Variagenics
shall, within a reasonable time thereafter, make available to Quintiles know-how
with respect to use of the Variagenics Technology licensed to Quintiles under
Section 4(a), through such reasonable written and oral disclosures and such
reasonable on site training as Quintiles may request. Without limiting the
generality of the foregoing, Variagenics will provide Quintiles with such
manuals, standard operating procedures, process descriptions and the like, as
Variagenics employs in its own utilization of such Variagenics Technology.
Variagenics will receive reasonable compensation for such activities on terms to
be agreed upon by the parties.

      5. Intellectual Property.

            (a) Variagenics Property. The parties agree that all Variagenics
Technology, as well as any additions or improvements to the Variagenics
Technology developed in the Alliance, will be owned by Variagenics, and shall be
available for Alliance Programs, except to the extent that Variagenics has
exclusively licensed Variagenics Gene Rights to third parties.


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            (b) Quintiles Property. The parties agree that all Quintiles
Technology, as well as any additions or improvements to the Quintiles Technology
developed in the Alliance, will be owned by Quintiles, and shall be available
for Alliance Programs.

            (c) Joint Property. Title to all inventions and other intellectual
property, including databases, technologies or processes, jointly made or
created by Quintiles and Variagenics in connection with and arising out of the
Alliance and the Alliance Programs ("Joint Technology") shall be deemed jointly
owned by Quintiles and Variagenics. Joint Technology shall not include Quintiles
Technology or Variagenics Technology or any additions or improvements thereto
developed in the Alliance. The parties will seek to identify all Joint
Technology and collaborate in its development. The parties will have the right
to sublicense the Joint Technology by mutual agreement.

      6. Term; Termination; Consequences of Termination.

            (a) Term. The term of this Agreement shall commence on the date of
this Agreement and shall expire on the fifth anniversary thereof, unless earlier
terminated pursuant to the provisions of this Agreement; provided, however, that
this Agreement shall remain in full force and effect with respect to any
Alliance Program for which an Alliance Agreement has been executed until such
Alliance Program has been completed or terminated and all provisions hereof
relating to such Alliance Program have been complied with by Quintiles and
Variagenics (an "Alliance Program Completion Date"). This Agreement may be
renewed by mutual written agreement of the parties. As used herein, the term
"Termination Date" shall mean the expiration of the term of this Agreement or
the earlier termination of this Agreement in accordance with this Section 6,
except that with respect to any particular Alliance Program (including Advances


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pursuant to Section 12 relating to such Alliance Program), such term shall mean
the later of the aforesaid date or the Alliance Program Completion Date.

            (b) Termination by Quintiles. This Agreement may be terminated by
Quintiles in the event of a material breach or default by Variagenics of the
terms and conditions of this Agreement (so long as Quintiles is not in material
breach or default of this Agreement); provided, however, Quintiles shall first
give Variagenics notice of the proposed termination, specifying the grounds
therefor, and Variagenics shall have 45 days after such notice to cure such
breach or default. If not so cured, this Agreement shall terminate at the
expiration of such 45 days. Quintiles also may terminate a particular Joint
Alliance Program if, in Quintiles' reasonable judgment, Variagenics' services to
clients within the Field outside of such Joint Alliance Program are in conflict
with or detrimental to a Sponsor for that Joint Alliance Program, but only after
referral of such matter to the Joint Management Committee and its failure to
resolve the matter within a reasonable time.

            (c) Termination by Variagenics. This Agreement may be terminated by
Variagenics in the event of a material breach or default by Quintiles of the
terms and conditions of this Agreement (so long as Variagenics is not in
material breach or default of this Agreement); provided, however, Variagenics
shall first give to Quintiles notice of the proposed termination, specifying the
grounds therefor, and Quintiles shall have 45 days after such notice to cure
such breach or default. If not so cured, this Agreement shall terminate at the
expiration of such thirty 45 days.

            (d) Termination by Either Party. This Agreement may be terminated by
either party after December 31, 2000 and before June 30, 2001 by 30 days prior
written notice, if


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Alliance Agreements providing for aggregate payments to Variagenics of at least
$3,000,000 have not been executed by December 31, 2000.

            (e) Consequences of Termination. Termination of this Agreement by a
party shall not affect any other rights or remedies which may be available to
such party against a defaulting party. Termination or expiration of this
Agreement shall not relieve any party of any obligation under this Agreement
which accrued or arose prior to such termination, including any obligation to
complete services under Alliance Programs then in progress or to make payments
required by this Agreement. Upon termination of this Agreement in accordance
with its terms, all rights to Variagenics Technology shall be returned to
Variagenics, and all rights to Quintiles Technology shall be returned to
Quintiles, except (in each case) (i) as previously licensed to Sponsors under
Alliance Programs then in progress and (ii) all licensed rights shall continue
after termination (on a non-exclusive basis) for the duration of all Alliance
Programs then in progress, solely for use in such Alliance Programs.

      7. Indemnification: Limitation of Liability.

            (a) Indemnification by Variagenics. Variagenics shall defend,
indemnify and hold harmless Quintiles, its affiliates and its and their
respective directors, officers, agents and employees from and against any and
all liability, loss, damage, claims, causes of action, costs and expenses
(including reasonable attorneys' fees and expenses) to or by any third party to
the extent proximately caused, directly or indirectly, by or as a result of (i)
a material breach or default by Variagenics of this Agreement, (ii) any willful
misconduct, negligent act or omission of Variagenics or any representative of
Variagenics in connection with Variagenics' performance of its obligations under
this Agreement, or (iii) the infringement or violation, or alleged


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infringement or violation, by Variagenics or the Variagenics Technology of any
patents or any copyright, trademark, trade secret or other intellectual property
right.

            (b) Indemnification by Quintiles. Quintiles shall defend, indemnify
and hold harmless Variagenics, its affiliates and its and their respective
directors, officers, agents and employees from and against any and all
liability, loss, damage, claims, causes of action, and costs and expenses
(including reasonable attorneys' fees and expenses) to or by any third party to
the extent proximately caused, directly or indirectly, by or as a result of (i)
any material breach or default under this Agreement by Quintiles, (ii) any
willful misconduct, negligent act of omission of Quintiles or any representative
of Quintiles in connection with Quintiles' performance of its obligations under
this Agreement, or (iii) the infringement or violation, or alleged infringement
or violation, by Quintiles or the Quintiles Technology of any patents or any
copyright, trademark, trade secret or other intellectual property right.

            (c) Indemnification Procedures. The party seeking indemnification
hereunder (the "Indemnified Party") shall: (a) give the party obligated to
indemnify (the "Indemnifying Party") prompt notice of any such claim or law suit
(including a copy thereof) served upon Indemnified Party; and (b) the
Indemnified Party shall fully cooperate with Indemnifying Party and its legal
representatives in the investigation of any matter the subject of
indemnification, and (c) the Indemnified Party shall not unreasonably withhold
its approval of the settlement of any such claim, liability, or action by the
Indemnifying Party covered by this indemnification provision unless such
settlement would require the Indemnified Party to be subject to any injunction
or to make a monetary payment or to take any action or refrain from taking any
action in the future; provided, however, that the Indemnified Party's failure to
comply with its obligations pursuant to this Section shall not constitute a
breach of this Agreement nor relieve


                                       19
<PAGE>

the Indemnifying Party of its indemnification obligations pursuant to this
Section, except to the extent, if any, that the Indemnifying Party's defense of
the affected claim, action or proceeding actually was materially impaired
thereby. The Indemnifying Party shall make reasonable efforts to minimize any
interruption in the normal conduct of the Indemnified Party's business in
requesting the Indemnified Party's cooperation and shall reimburse the
Indemnified Party's reasonable out-of-pocket expenses. The Indemnified Party may
use the same counsel, selected by the Indemnifying Party, as joint counsel in
the defense of any such claim, unless the Indemnified Party, in the exercise of
commercially reasonable judgment, determines that it needs to retain separate
counsel because of an actual or potential conflict of interest between the
Indemnifying Party and the Indemnified Party.

            (d) Limitation of Liability. Neither party or its affiliates, nor
any of its or their respective directors, officers, employees or agents shall
have any liability for any special, incidental, or consequential damages,
including without limitation for loss of opportunity, loss of revenue or profit,
or loss of the use of any data or information supplied hereunder, in connection
with or arising out of this Agreement, even if the party shall have been advised
of the possibility of such damages.

      8. Dispute Resolution. (a) The parties will attempt in good faith to
resolve any controversy or claim between the parties arising out of or relating
to this Agreement promptly by negotiations between the parties. Any such matter
which is not so resolved shall be referred promptly to the Joint Management
Committee, who shall meet and endeavor in good faith to resolve the same within
15 days after their meeting for such purpose. If the Joint Management Committee
is unable unanimously to resolve any matter before it, the Joint Management
Committee shall promptly notify a high-ranking corporate officer designated by
each party who


                                       20
<PAGE>

will meet at least once and attempt to resolve the matter. If such executive
officers are unable to resolve the matter within 15 days, then either party may
pursue any available remedies under this Agreement or otherwise available.

            (b) Arbitration. Any controversy, dispute or claim arising out of or
in connection with this Agreement, or the breach, termination or validity hereof
that is not resolved pursuant to Section 8(a), shall be settled by final and
binding arbitration to be conducted by an arbitration tribunal in New York, New
York pursuant to the commercial arbitration rules of the American Arbitration
Association. The arbitration tribunal shall consist of three arbitrators. The
party initiating arbitration shall nominate one arbitrator in the request for
arbitration and the other party shall nominate a second in the answer thereto
within thirty (30) days of receipt of the request. The two arbitrators so named
will then jointly appoint the third arbitrator. If the answering party fails to
nominate its arbitrator within the thirty (30) day period, or if the arbitrators
named by the parties fail to agree on the third arbitrator within thirty (30)
days, the office of the American Arbitration Association in New York, New York
shall make the necessary appointments of such arbitrator(s). The arbitrators
shall be requested to (i) establish a procedure and timetable for discovery and
trial which will complete all hearings within ninety (90) days after appointment
of the third arbitrator, and (ii) render their decision within fifteen (15) days
after completion of all hearings. Each party shall pay the costs of its
respective arbitrator, and the parties shall share equally the costs of the
third arbitrator. The decision or award of the arbitration tribunal (by a
majority determination, or if there is no majority, then by the determination of
the third arbitrator) shall be final, and judgment upon such decision or award
may be entered in any competent court or application may be made to any
competent court for judicial acceptance of such decision or award and an order
of enforcement. In the event


                                       21
<PAGE>

of any procedural matter not covered by the aforesaid rules, the procedural law
of the State of New York shall govern.

      9. Representations and Warranties.

            (a) Representations and Warranties of Variagenics. Variagenics
hereby represents and warrants to Quintiles as follows:

                  (i) Variagenics has duly executed and delivered each of this
Agreement and the Note and each of this Agreement and the Note constitute the
valid and binding obligation of Variagenics, enforceable against Variagenics in
accordance with its terms.

                  (ii) Variagenics owns the entire right, title and interest in
and to the Variagenics Technology, or has sufficient rights therein, to use the
Variagenics Technology for the purposes set forth in this Agreement. To
Variagenics' knowledge, the Variagenics Technology to be used as contemplated by
this Agreement does not infringe or violate any patents or any copyright,
trademark, trade secret or other intellectual property right, and there are no
claims of any such infringement or violation which have been asserted to
Variagenics. Variagenics agrees that it will not knowingly use as contemplated
by this Agreement any patent, copyright, trademark, trade secret or other
intellectual property in a manner that infringes on the rights of any third
party.

                  (iii) Variagenics is not a party to any strategic relationship
relating to marketing of Variagenics Services or Variagenics Technology in
combination with Clinical Services in the Field or to any agreement or
arrangement (other than licenses of Variagenics Gene Rights) which could in any
material way restrict it from fulfilling its obligations under this Agreement.
Until December 31, 2000, Variagenics shall not enter into any third-party
strategic


                                       22
<PAGE>

alliance relating to marketing of Variagenics Services or Variagenics Technology
in combination with Clinical Services in the Field. Variagenics will not enter
into any agreement or arrangement (other than licenses of Variagenic Gene
Rights) which could in any material way restrict Variagenics' ability to perform
its obligations under this Agreement or any Alliance Program, including the
grant of any right or interest in or to any Variagenics Technology, except as
expressly contemplated or permitted by this Agreement.

            (b) Representations and Warranties of Quintiles. Quintiles hereby
represents and warrants to Variagenics as follows:

                  (i) Quintiles has duly executed and delivered this Agreement
and this Agreement constitutes the valid and binding obligation of Quintiles,
enforceable against Quintiles in accordance with its terms.

                  (ii) Quintiles owns the entire right, title and interest in
and to the Quintiles Technology, or has sufficient rights therein, to use the
Quintiles Technology for the purposes set forth in this Agreement. To Quintiles'
knowledge, the Quintiles Technology, as it currently exists, to be used as
contemplated by this Agreement does not infringe or violate any patents or any
copyright, trademark, trade secret or other intellectual property right, and
there are no claims of any such infringement or violation which has been
asserted to Quintiles.

                  (iii) Quintiles is not a party to any strategic relationship
relating to marketing of Clinical Services in combination with services or
technology of third parties in the Field or to any agreement or arrangement
which could in any material way restrict it from fulfilling its obligations
under this Agreement. Until December 31, 2000, Quintiles shall not enter into
any third-party strategic alliance relating to marketing of Clinical Services in
combination with services or technology of third parties in the Field. Quintiles
will not enter into


                                       23
<PAGE>

any agreement or arrangement which could in any material way restrict Quintiles'
ability to perform its obligations under this Agreement or any Alliance Program
or otherwise impact the viability of the Alliance, except as expressly
contemplated or permitted by this Agreement.

      10. Confidentiality. In connection with any Alliance Program or otherwise
in connection with this Agreement or the conduct of the Alliance, each party
(the "Recipient") may receive, either intentionally or unintentionally, certain
oral and written proprietary and confidential information of the other party
(the "Disclosing Party") (or a third party providing such information to the
Disclosing Party) which is not otherwise a part of the public domain
("Proprietary Information"). Proprietary Information includes, but is not
limited to, intellectual property, know-how, trade secrets, computer software,
pricing information, physician lists, investigation/nurse coordinator network
lists, mailing lists, subject and patient lists, employee lists, fee schedules,
client and customer lists, programmactical information and structure,
utilization review procedures, proprietary sequence information, variance
discovery and variance detection techniques, pharmacogenomics algorithms,
applications and procedures, formats and structure and related information and
documents concerning the planning, structure and operations of the Disclosing
Party or relating to its business affairs. Each party (for itself, its
affiliates and its and their respective directors, officers, employees, agents,
subcontractors, affiliates and representatives) agrees that all Proprietary
Information shall be disclosed to the Recipient's directors, officers,
employees, agents, subcontractors, affiliates and representatives only on a
need-to-know basis for the purposes of carrying out the purposes of any Alliance
Program, this Agreement or the Alliance. Each party further agrees to keep all
Proprietary Information in the strictest confidence, to use the Proprietary
Information only in furtherance of the purposes of this Agreement, not to
duplicate, transmit, reverse engineer, decompile, or


                                       24
<PAGE>

disassemble any Proprietary Information, and not to, directly or indirectly,
divulge, disclose, reveal, report, or transfer such Proprietary Information to
any third party without, in each instance, obtaining specific, prior written
authorization of the Disclosing Party. Each party further agrees that all health
records of patients or subjects of the investigators participating in any
Alliance Program shall be treated as confidential so as to comply with all state
and federal laws and regulations and industry standards regarding the
confidentiality of patent health records and research records. Subject to the
right of access provided herein, any Proprietary Information developed by either
party in connection with the Alliance shall be and remain the property of the
party which developed such Proprietary Information, except as provided in
Section 5(c).

      Notwithstanding the foregoing, the obligations set forth above shall not
prevent either party from disclosing information:

            (a) which is or becomes generally available to the public other than
as a result of a disclosure by or at the direction of, the Recipient or its
affiliates or their respective directors, officers, employees, agents, advisors,
and other representatives;

            (b) was or becomes available to the Recipient on a non-confidential
basis from a source other than the Disclosing Party or its representatives,
provided that such source is not bound by a confidentiality agreement with the
Disclosing Party in respect thereof (unless the Recipient did not know or have
reason to know of the existence of such a confidentiality agreement);

            (c) was within the Recipient's possession prior to its being
furnished to the Recipient by or on behalf of the Disclosing Party, provided
that the source of such information was not bound by a confidentiality agreement
with the Disclosing Party in respect thereof (unless


                                       25
<PAGE>

the Recipient did not know or have reason to know of the existence of such a
confidentiality agreement); or

            (d) which the Recipient can demonstrate was developed independently
of any disclosure by the Disclosing Party by persons having no access to any
disclosure of the Disclosing Party.

      Notwithstanding any provisions herein to the contrary, in the event that
any recipient of Proprietary Information becomes obligated by mandatory
applicable law, regulatory rule or judicial or administrative order to disclose
such Proprietary Information, or any portion thereof, the Recipient shall
promptly notify the Disclosing Party thereof, so that the Disclosing Party may
seek an appropriate protective order or other remedy with respect to resisting
or narrowing the scope of such requirement. In the absence of such a protective
order or other remedy, the Recipient may disclose such Proprietary Information
without liability hereunder, provided that the Recipient furnishes only such
portion of the Proprietary Information as is legally required to be disclosed.

       11. Non-Solicitation. During the period from the date hereof, through and
including the first anniversary of the date of expiration or termination of this
Agreement or any extensions thereof (regardless of the reason for termination),
neither party shall, directly or indirectly through one or more intermediaries,
employ, contract with, solicit for employment or engagement, or advise or
recommend to any other person or entity that such person or entity employ or
solicit for employment or engagement, any person who at any time during the term
of this Agreement is or was an employee of the other party within the previous
one year, including a person employed with respect to an Alliance Program,
without, in each instance, obtaining the


                                       26
<PAGE>

prior written consent of the other Party. Consent may be withheld in the party's
absolute discretion.

      12. Financing from Quintiles to Variagenics.

            (a) Advances by Quintiles to Variagenics. Quintiles agrees, on the
terms and conditions set forth below, to make advances (the "Advances") to
Variagenics from time to time during the period from the date of this Agreement
until the Termination Date. Each advance shall be a loan from Quintiles to
Variagenics and Variagenics' obligations to pay the principal amount of the
Advances thereon shall be evidenced by the promissory note dated the date of
this Agreement and executed by Variagenics and delivered to Quintiles (the
"Note").

            (b) Making of Advances. At any time after a Sponsor has accepted a
Joint Alliance Program proposal made by Quintiles and Variagenics, as evidenced
by an Alliance Agreement between Quintiles and such Sponsor, Variagenics may
deliver to Quintiles a written request (an "Advance Request") for an Advance in
an amount equal to the Applicable Percentage (as defined below) of the
Qualifying Program Revenues (as defined below). Each Advance Request shall be in
writing and be delivered in accordance with Section 13(d). Each Advance Request
shall be irrevocable and binding on Variagenics, and Variagenics shall reimburse
Quintiles for any reasonable cost or expense incurred by Quintiles as a result
of any revocation or attempted revocation of such Advance Request, including any
cost or expense incurred by reason of Quintiles borrowing to fund the Advance.
Within 30 days of the receipt by Quintiles of an Advance Request, Quintiles
shall make such Advance by wire transfer of immediately available funds to an
account designated by Variagenics so long as (i) no Event of Default exists, and
(ii) Variagenics has complied with all conditions precedent to such Advance
described below. "Qualifying Program Revenues" shall mean (x) the amount of
revenues which are


                                       27
<PAGE>

attributable to Variagenics Services or Variagenics Technology rendered by
Variagenics and which are payable by a Sponsor under a Joint Alliance Program
during the period beginning on the date of the Alliance Agreement for such Joint
Alliance Program and ending on the earlier of (i) the date which is one year
following the date of the applicable Advance Request or (ii) the Termination
Date of such Alliance Program, all as determined pursuant to the terms of such
definitive agreement, or if the Qualifying Program Revenues are not determinable
on the face of the Alliance Agreement, then as determined by mutual agreement by
Quintiles and Variagenics consistent with the foregoing definition, less (y) the
amount of any Qualifying Program Revenues which have previously been paid by the
Sponsor. "Applicable Percentage" shall mean (x) with respect to Joint Alliance
Programs with the Sponsors who have revenues in the current or preceding fiscal
year of at least $100,000,000, 80%, and (y) with respect to Joint Alliance
Programs with any Sponsor. other than as described in the foregoing clause (x),
between 60% and 80%, with the specific percentage to be negotiated in good faith
by the parties, taking into account appropriate factors, including the perceived
risk of nonpayment by the Sponsor, prior payment history by the Sponsor to
either of the parties, and the nature and terms of the Joint Alliance Program
(including the amount of payments due under the Joint Alliance Program).
Notwithstanding anything to the contrary in this Agreement, Quintiles shall have
no obligation to make any Advance after this Agreement is terminated pursuant to
Section 6, except for Advances for Alliance Programs that continue after such
termination pursuant to Section 6, or after the occurrence of an Event of
Default. In addition, Quintiles shall have no obligation to make any Advance
unless and until Variagenics has obtained the written agreement of Imperial Bank
to subordinate its security interest in the Collateral to the security interest
in the Collateral granted to Quintiles by this Agreement.


                                       28
<PAGE>

            (c) Application of Alliance Program Revenues to Advances. Upon
receipt by Quintiles of revenues from a Sponsor pursuant to a Joint Alliance
Program, Quintiles shall, after retaining for Quintiles the amounts provided in
Section 3(e), apply such revenues as follows: first, to repay any Advances made
with respect to such Joint Alliance Program; second, to repay any other
outstanding Advances under any other Joint Alliance Programs; and third, any
remaining revenues to Variagenics in accordance with Section 3(e).

            (d) Repayment of Advances; Certain Other Obligations.

                  (i) To the extent not paid pursuant to Section 12(c), all
Advances shall be due and payable by Variagenics upon the earlier of (A) the
receipt by Quintiles of revenues under a Joint Alliance Program with respect to
which an Advance was made, or (B) the Termination Date of the Alliance Program
to which an Advance relates, except as otherwise provided in Section 12(h).
Notwithstanding anything in this Agreement or the Note to the contrary,
Quintiles agrees that if Variagenics has rendered Variagenics Services pursuant
to a Joint Alliance Program and if a Sponsor fails to pay revenues under a Joint
Alliance Program for which an Advance has been made to Variagenics, then
Quintiles will refrain from pursuing collection of such Advance from
Variagenics, unless in the event such Sponsor has indicated in writing to
Quintiles or Variagenics that the reason for such Sponsor's failure to pay such
revenues or any portion thereof is that such Sponsor is dissatisfied with the
Variagenics Services under the Joint Alliance Program and continues to be
dissatisfied after the meeting contemplated by Section 12(d)(ii). In such event,
the parties agree that Quintiles shall have full recourse against Variagenics to
obtain repayment of such Advance. Nothing contained in this subsection (d),
however, shall limit Quintiles' right at any time to apply any revenues received
from Sponsors under Joint Alliance Programs to Advances as described in
subsection (c) above.


                                       29
<PAGE>

                  (ii) In the event that a Sponsor has indicated to Quintiles or
Variagenics that it is dissatisfied with the Variagenics Services under a Joint
Alliance Program, as described above, Variagenics and Quintiles will meet with
the Sponsor to resolve the matter. If after such meeting the Sponsor indicates
in writing to Quintiles or Variagenics that the Sponsor continues to be
dissatisfied with the Variagenics Services under a Joint Alliance program,
Variagenics agrees:

                        (A) to provide again such services to the satisfaction
of the Sponsor, at no additional cost or expense to the Sponsor, or

                        (B) if requested by the Sponsor, to cause a third party
(in lieu of Variagenics) to provide such services to the satisfaction of the
Sponsor, at Variagenics' cost and expense.

            (e) Grant of Security Interest.

                  (i) As security for the prompt and complete payment and
performance of all Advances and the Note, Variagenics does hereby assign,
transfer and pledge to Quintiles and does hereby grant to Quintiles a continuing
security interest of first priority in all right, title and interest of
Variagenics in, to and under all cash and all "accounts," "contract rights,"
"general intangibles," "instruments," and the "proceeds" thereof or claims
relating thereto (as such terms are used or defined in the Uniform Commercial
Code) in each case which from time to time relate to or arise out of any amounts
payable to Variagenics or otherwise attributable to Variagenics or Variagenics
Services or Variagenics Technology under Joint Alliance Programs or any amounts
payable by Quintiles to Variagenics under Joint Alliance Programs (collectively,
the "Collateral").


                                       30
<PAGE>

                  (ii) Variagenics represents, warrants and covenants, as
follows:

                        (A) All filings, registrations and recordings necessary
or appropriate to create, preserve, protect and perfect the security interests
granted by Variagenics to Quintiles hereby in respect of the Collateral have
been accomplished, and the security interest granted to Quintiles pursuant to
this Agreement in and to the Collateral constitutes a valid and enforceable
perfected security interest therein superior and prior to the rights of all
other persons therein and is entitled to all the rights, priorities and benefits
afforded by the Uniform Commercial Code or other applicable law as enacted in
any relevant jurisdiction to perfected security interests;

                        (B) on the date of this Agreement, except for a security
interest granted to Imperial Bank ("Imperial Bank"), the Collateral is free of
any liens, security interests or encumbrances and there exists no financing
statement (or similar statement or instrument or registration under the law of
any jurisdiction) covering or purporting to cover any interest of any kind in
the Collateral, and so long as any of the Advances remain unpaid, Variagenics
will not execute or authorize to be filed in any public office any security
agreement or financing statement (or similar statement or instrument or
registration under the law of any jurisdiction) relating to a security interest
senior to the security interest granted in this Agreement with respect to the
Collateral;

                        (C) the chief executive office of Variagenics is located
at Cambridge, Massachusetts and Variagenics will not establish a new location
for its chief executive office until Variagenics shall have given to Quintiles
not less than 30 days' prior written notice of its intention so to do, clearly
describing such new location and providing such other information in connection
therewith as Quintiles may reasonably request; and


                                       31
<PAGE>

                        (D) neither the execution and delivery of this Agreement
and the other documents executed in connection herewith, nor consummation of any
of the transactions herein contemplated, nor compliance with the terms and
provisions hereof, will contravene or conflict with any provision of law,
statute or regulation to which Variagenics is subject or any judgment, license,
order or permit applicable to Variagenics or any indenture, mortgage, deed of
trust, agreement or other instrument to which Variagenics is a party or by which
Variagenics may be bound, or to which Variagenics may be subject, or violate or
contravene any provision of the bylaws of Variagenics or the instruments of
incorporation forming Variagenics.

                  (iii) Variagenics will, at its own expense, make, execute,
endorse, acknowledge, file or deliver to Quintiles from time to time such
confirmatory assignments, conveyances, financing statements, powers of attorney,
certificates, reports, and other assurances or instruments and take such further
steps relating to the Collateral as Quintiles deems reasonably appropriate or
advisable to perfect, preserve or protect its security interest in the
Collateral.

                  (iv) Variagenics agrees that, if any Event of Default (as
defined in the Note) shall have occurred and be continuing, then and in every
such case, Quintiles, in addition to any rights now or hereafter existing under
applicable law, shall have all rights as a secured creditor under the Uniform
Commercial Code in all relevant jurisdictions.

            (f) Conditions Precedent to Initial Advance. The obligation of
Quintiles to make the initial Advance is subject to the condition precedent that
Quintiles shall have received on or before the day of such Advance the
following, in form and substance satisfactory to Quintiles:


                                       32
<PAGE>

                  (i) the Note, duly executed by Variagenics;

                  (ii) acknowledgment copies or stamped receipt copies of proper
financing statements, duly filed under the Uniform Commercial Code of all
jurisdictions that Quintiles may deem necessary or desirable in order to perfect
the security interests created in the Collateral;

                  (iii) completed requests for information, listing the
financing statements referred to in paragraph (ii) above and all other effective
financing statements filed in the jurisdictions referred to in paragraph (ii)
above that name Variagenics as debtor, together with copies of such other
financing statements (none of which shall cover the Collateral);

                  (iv) evidence of the completion of all recordings and filings
of or with respect to the Collateral that Quintiles may deem necessary or
desirable in order to perfect the security interests created in the Collateral;

                  (v) evidence that all other actions necessary or, in the
opinion of Quintiles, desirable to perfect and protect the security interests
created in the Collateral have been taken;

                  (vi) certified copies of the resolutions of the Board of
Directors of Variagenics approving each of this Agreement and the Note
(collectively, the "Loan Documents"), and of all documents evidencing other
necessary corporate action and governmental approvals, if any, with respect to
each such Loan Document; and

                  (vii) a favorable opinion of counsel for Variagenics,
substantially in the form of Exhibit B.


                                       33
<PAGE>

            (g) Conditions Precedent to All Advances. The obligation of
Quintiles to make each Advance (including the initial Advance) shall be subject
to the further conditions precedent that, on the date of such Advance, the
following statements shall be true and Quintiles shall have received a
certificate signed by a duly authorized officer of Variagenics dated the date of
such Advance, stating that (and each of the giving of the applicable notice
requesting such Advance and the acceptance by Variagenics of the proceeds of
such Advance shall constitute a representation and warranty by Variagenics that
on the date of such Advance such statements are true):

                        (A) the representations, warranties and covenants
contained in Section 1 2(e)(ii) of this Agreement are correct on and as of the
date of such Advance, before and after giving effect to such Advance and to the
application of the proceeds therefrom, as though made on and as of such date,
and

                        (B) no event has occurred and is continuing, or would
result from such Advance or from the application of the proceeds therefrom,
which constitutes an Event of Default (as defined in the Note) or would
constitute an Event of Default but for the requirement that notice be given or
time elapse or both.

            (h) Certain Events of Default. The occurrence of any one or more of
the following events shall constitute an "Event of Default":

                        (A) Variagenics shall fail to pay this Note or any
portion thereof when due;

                        (B) Quintiles shall terminate this Agreement pursuant to
Section 8;


                                       34
<PAGE>

                        (C) Variagenics shall fail to pay when due, whether by
scheduled maturity, acceleration or otherwise, any material indebtedness under
Senior Debt or any other default or event of default shall occur under the terms
of any agreement or instrument pursuant to which Variagenics has incurred any
Senior Debt, as a result of which default such Senior Debt shall be declared to
be due and payable prior to the stated maturity thereof;

                        (D) Variagenics shall (i) file a voluntary petition or
commence a voluntary case seeking liquidation, reorganization, dissolution,
arrangement, readjustment of debts or any other relief under the U.S. Bankruptcy
Code or under any other applicable bankruptcy, insolvency or similar law now or
hereafter in effect, (ii) consent to the appointment of or taking possession by
a custodian, trustee, receiver or similar official for or of all or a
substantial part of its properties, (iii) fail generally to pay its debts as
they become due or admit in writing its inability to pay its debts generally as
they become due, or (iv) make a general assignment for the benefit of creditors;
or Variagenics shall take any action to authorize or approve any of the actions
described above;

                        (E) Any involuntary petition or case shall be filed or
commenced against Variagenics seeking liquidation, reorganization, dissolution,
arrangement, readjustment of debts, the appointment of a custodian, trustee,
receiver or similar official for it or all or a substantial part of its
properties or any other relief under the U.S. Bankruptcy Code or under any other
applicable bankruptcy, insolvency or similar law now or hereafter in effect,
which petition or case is not dismissed, bonded or discharged within 60 days of
the date of filing; or an order for relief (including, without limitation, the
appointment of a custodian, trustee, receiver or similar official) shall be
entered in any such proceeding, which order is not immediately stayed or made
subject to other similar relief; or


                                       35
<PAGE>

                        (F) the dissolution, liquidation or termination of
Variagenics. Upon and at any time after the occurrence and during the
continuance of any Event of Default, Quintiles may (i) declare in writing all or
any part of the Note or the Advances to be immediately due and payable,
whereupon such amounts shall become immediately due and payable; provided,
however that, upon the occurrence of an Event of Default pursuant to Sections I
2(h)(D) and (E) above, all of such amounts shall automatically become
immediately due and payable, and (ii) exercise all rights and remedies available
to it under, and subject to, this Agreement, the Note and applicable law.

                  (i) Subordination. The payment of Advances shall be
subordinate to the payment of all Senior Debt as provided in this Section 12(i).
Upon the default of Senior Debt, pursuant to which such Senior Debt shall be
declared to be due and payable prior to the stated maturity thereof, Quintiles
shall refrain from pursuing collection of Advances from Variagenics as described
in Section 12(d) for a period beginning on the date Quintiles receives written
notice from the holder of such Senior Debt and ending on the earlier of (A) the
date on which Variagenics has paid all amounts then due and payable under such
Senior Debt and (B) 120 days after the date of such notice. Nothing contained in
this Section 12(i), however, shall limit Quintiles' right at any time to apply
any revenues received from Sponsors under Joint Alliance Programs to Advances as
described in Section 12(c) above or to exercise its rights and remedies with
respect to the Collateral.

                  (j) Costs. Expenses and Taxes. Variagenics agrees to pay on
demand all costs and expenses, if any (including reasonable attorneys' fees and
expenses), in connection with the enforcement (whether through negotiations,
legal proceedings or otherwise) of the Note and the provisions of this Section
12, including, without limitation, reasonable attorneys fees and


                                       36
<PAGE>

expenses in connection with the enforcement of rights under this Section. In
addition, Variagenics shall pay any and all stamp and other taxes payable or
determined to be payable in connection with the execution, delivery, filing and
recording of the Loan Documents and the other documents to be delivered under
the Loan Documents, and agrees to save Quintiles harmless from and against any
and all liabilities with respect to or resulting from any delay in paying or
omission to pay such taxes.

                  (k) Interest and Loan Charges Not to Exceed Maximum Allowed by
Law. Anything in this Agreement or the Note to the contrary notwithstanding, in
no event whatsoever, whether by reason of advancement of proceeds of the loans
made pursuant to this Agreement, acceleration of the maturity of the unpaid
balance of the loans or otherwise, shall any interest or loan charges agreed to
be paid to Quintiles for the use of the money advanced or to be advanced
hereunder exceed the maximum amounts collectible under applicable laws in effect
from time to time. It is understood and agreed by the parties that, if for any
reason whatsoever the interest or loan charges paid or contracted to be paid by
Variagenics in respect of the indebtedness evidenced by the Loan Documents shall
exceed the maximum amounts collectible under applicable laws in effect from time
to time, then ipso facto, the obligation to pay such interest or loan charges
shall be reduced to the maximum amounts collectible under applicable laws in
effect from time to time, and any amounts collected by Quintiles that exceeds
such maximum amounts shall be applied to the reduction of the principal balance
of the indebtedness evidenced by the Note or refunded to Variagenics so that at
no time shall any interest or loan charges paid or payable in respect of the
indebtedness evidenced by the Note exceed the maximum amounts permitted from
time to time by applicable law.

      13. Miscellaneous.


                                       37
<PAGE>

            (a) Assignment: Parties in Interest. This Agreement or any of the
rights or obligations hereunder may not be assigned, transferred or
subcontracted (except as provided in Section 3(c)(ii)(B)) by any party hereto
without the prior written consent of the other party; provided, however, that
Quintiles may assign this Agreement to any affiliate of Quintiles. In the event
Variagenics proposes to engage in a sale of all or substantially all of its
assets in the line of business to which this Agreement pertains or to engage in
any merger or consolidation, as a result of which (in either case) stockholders
of Variagenics immediately prior to such transaction do not own a majority of
the voting shares of the resulting or surviving corporation immediately after
such transaction (a `Transaction"), Variagenics shall give Quintiles written
notice (a `Transaction Notice") of such Transaction at least forty-five (45)
days prior to the date anticipated for consummation thereof. Quintiles shall
have a period of thirty (30) days after receipt of the Transaction Notice in
which to give Variagenics written notice (a "Negative Response") that Quintiles
intends to terminate this Agreement upon consummation of such Transaction, in
which event Variagenics shall notify Quintiles of such consummation and
Quintiles shall have a period of ten (10) days after such consummation to
terminate this Agreement. If Quintiles does not give a Negative Response within
such thirty (30) days, Quintiles will be deemed to have given prior written
consent to the Transaction and the assignment of this Agreement in connection
therewith. This Agreement shall be binding upon and inure to the benefit of the
parties hereto and their respective successors and permitted assigns. Each party
hereto intends that this Agreement shall not benefit or create any right or
cause of action in or on behalf of any person other than the parties hereto,
except as set forth in Section 7 hereof.


                                       38
<PAGE>

            (b) Amendment and Waiver. This Agreement or any provision hereof may
not be amended, changed, modified or waived, except by written instrument signed
by the parties hereto. The failure of any party at any time or times to require
performance of any provision of this Agreement shall in no manner affect the
right of such party at a later date to enforce the same. No waiver by any party
of any condition or the breach of any provision, term, covenant, representation
or warranty contained in this Agreement, whether by conduct or otherwise, in any
one or more instances shall be deemed to be or construed as a further or
continuing waiver of any such condition or of the breach of any other provision,
term, covenant, representation or warranty of this Agreement.

            (c) Remedies. The rights and remedies set forth in this Agreement
are cumulative and not exclusive of any rights or remedies provided by law or
otherwise. The exercise by a party of any right or remedy will not preclude such
party from exercising any other right or remedy, and no single or partial
exercise of any right or remedy shall preclude any other or further exercise
thereof. A party may pursue its rights and remedies in such order as it
determines.

            (d) Notices. All notices required or permitted to be given under
this Agreement shall be in writing, and shall be delivered personally or sent by
(a) registered or certified mail, return receipt requested, (b) a nationally
recognized courier service guaranteeing next-day delivery and providing evidence
of receipt, charges pre-paid or (c) facsimile transmission with confirmation of
receipt (with the original promptly sent by any of the foregoing manners), and
shall be deemed to be duly given upon mailing, delivery to such courier, or upon
transmission by facsimile, as the case may be. Any such notice shall be
addressed to the receiving party at such party's address set forth beside its
signature to this Agreement below, or


                                       39
<PAGE>

at such other address as may from time to time be furnished by a party to the
other party by notice as described above.

            (e) Governing Law: Jurisdiction. The construction, validity,
interpretation and performance of this Agreement shall be governed by and
construed in accordance with the laws of the State of North Carolina, without
regard to the conflicts of laws principles thereof.

            (f) Severability. In case any provision in this Agreement shall be
held to be invalid, illegal or unenforceable, the validity, legality and
enforceability of the remaining provisions hereof will not in any way be
affected or impaired thereby.

            (g) Entire Agreement: Integration. This Agreement constitutes the
full understanding of the parties and a complete statement of the terms. of
their agreement with respect to the subject matter contained herein and
supersedes and cancels all prior agreements, negotiations, correspondence,
undertakings and communications of the parties, oral or written, respecting such
subject matter. Notwithstanding the foregoing, all prior agreements between the
parties regarding confidentiality shall remain in full force and effect.

            (h) Headings: Exhibits. The article, section and paragraph headings
contained in this Agreement have been inserted for reference convenience only
and shall not be used in any way to construe or interpret this Agreement. All
Exhibits to this Agreement are specifically incorporated herein by reference.

            (i) Counterparts. This Agreement and any amendment or supplement
hereto may be executed in any number of counterparts, each of which when
executed and delivered shall be deemed to be an original and all of which
counterparts taken together shall constitute but one and the same instrument.


                                       40
<PAGE>

            (j) Publicity. The parties will agree upon a press release which
shall be issued promptly after the execution of this Agreement. Except as
otherwise required by applicable law, no party shall issue any press release or
make any other public statement relating to, connected with or arising out of
this Agreement or the matters contained herein without the prior written
approval by the other party of the contents and the manner of presentation and
publication thereof, which approval shall not be unreasonably withheld. Once a
particular item of information has been disclosed as provided in this subsection
(j), either party may make subsequent disclosure of such information without
further approval of the other party, except that any further press release shall
be mutually approved by the parties.


                                       41
<PAGE>

IN WITNESS WHEREOF, the parties have duly executed this Agreement effective as
of the date first above written.

Address: P.O. Box 13979                   QUINTILES TRANSNATIONAL CORP.
         -----------------
Research Triangle Park, NC
--------------------------
27709
--------------------------

Attention: Mr. Reynders                   By: /s/ Ludo Reynders
          ----------------                   --------------------------------

                                          Name: Ludo Reynders

                                          Title: CEO Quintiles CRO Division


Address: Variagenics, Inc.                VARIAGENICS, INC.
         -----------------
60 Hampshire Street
--------------------------
Cambridge, MA 02139
--------------------------

Attention: Fred D. Ledley                 By: /s/ Fred D. Ledley, M.D.
          ----------------                   --------------------------------

                                          Name: Fred D. Ledley, M.D.

                                          Title: President


                                       42
<PAGE>

Exhibit A: Price Schedule for Alliance Programs

1. Variance Discovery and Database

(a) Provided to Sponsor:

i.    Summary Report on variances within selected genes involved in the
      pharmacokinetics and pharmacodynamics of a specified pharmaceutical
      product under development, based on screening of a standard sample
      population. For each variance, Variagenics will determine the location of
      the variance, the base change, the predicted effect on the amino acid
      sequence and an estimate of population and sub-population frequencies.

ii.   Database which integrates data on variances discovered in specified genes
      and publicly available information on variances in these genes, their
      chemical, biological and clinical significance (if known) and selected
      literature references.

iii.  Right of first negotiation, for a period of ninety (90) days from delivery
      of the Summary Report and Database(1), to obtain a license, on
      commercially reasonable terms to be negotiated in good faith, to use
      variances discovered by Variagenics and included in report.

(b) Minimum prices:

Variance Discovery and Database capabilities will be priced based on the size of
the pathway to be analyzed for genetic variances.

                      -------------------------------
                      Pathway Size(2)    Minimum Bid
                       (# genes(3))      Price ($000)
                      -------------------------------
                           [  ](4)         [  ]
                      -------------------------------
                           [  ]            [  ]
                      -------------------------------
                           [  ]            [  ](5)
                      -------------------------------

Samples will be screened from [  ] unrelated individuals(6) drawn from an
ethnically diverse standard panel established at Variagenics, which will give a
[  ]% sensitivity to detect alleles occurring at a frequency of [  ]% in the
population represented by the panel.(7)

(c) Additional items priced on request:

i.    Candidate gene selection studies, such as differential gene expression or
      gene linkage.

ii.   Construction of custom panels, including tissue-specific samples(8) and
      population panels for characterization of allele frequencies in specific
      ethnic or disease groups.

iii.  Gene cloning and sequencing or analysis of genomic sequences.

iv.   Rights to use variance information in product research, development or
      marketing.

----------
(1) The Summary Report and Database will be delivered within 3-6 months of
project initiation, to be agreed in advance.

(2) Prices for pathways of intermediate size will be calculated by
interpolation. For example, the price for a [              ].

(3) Prices reflect an [                         ].

(4) Unless otherwise agreed by Variagenics, a limit of one pilot program
representing [     ] genes may be performed for a customer to demonstrate
Variance Discovery and Database capabilities.

(5) Minimum bids for pathways of greater than [ ] genes will be calculated by
extrapolation. For example, the price of a [   ]. Additional reductions in
[                                        ] may be negotiated with the prior
approval of Variagenics.

                                                                               1
<PAGE>

(6) Panels of either [  ] or [  ] individuals may be screened upon request,
giving a [  ]% sensitivity to detect alleles occurring at a frequency of
[            ]% respectively, which will add [          ]%, respectively to
the minimum bid price for the pathway. For example, [                   ].

(7) Minimum bids for pathways with different numbers of individuals screened for
different genes can be calculated [        ]. For example, [         ].

(8) Although not observed to date, some genes may not be expressed at levels
sufficient to be amplified from standard lymphocyte cDNA panels, requiring the
construction of tissue-specific panels.


Exhibit A: Price Schedule for Alliance Programs

2. Pharmacogenomic Services

(a) Provided to Sponsor:
Combinations of services will be provided to fit the project specifications
agreed upon with Sponsors, including, but not limited to:

i.    Clinical Pharmacogenomic Services:

      (A)   Quantitative, molecular, population, evolutionary, epidemiological
            genetics.
      (B)   Medical and clinical genetics.
      (C)   Pharmacogenetic statistics, including power estimation, association
            and cladistic analyses and proprietary statistical algorithms.
      (D)   Development of pharmacogenomic hypotheses and research plan to test
            hypotheses.
      (E)   Protocol and report writing, data management and biostatistics.
      (F)   Health outcomes, competitive dynamics and commercial modeling.
      (G)   Investigator meeting support and investigator site training.

ii.   Non-clinical Pharmacogenomic Services:

      (A)   Candidate gene selection studies, such as differential gene
            expression or other biochemical analyses.
      (B)   Experimental studies to confirm structural or functional effects of
            genetic variance.
      (C)   Pharmacology and medicinal chemistry.
      (D)   Molecular modeling and simulation.
      (E)   Development of functional and binding affinity assays for screening
            drug compounds.

(b) Minimum prices:

Pharmacogenomic Services will be priced on a Full Time Equivalent basis as
follows:

          -----------------------------------------------------
                                         Minimum Bid Price
          Pharmacogenomic Services   ($000 per FTE per Year(9))
          -----------------------------------------------------
          Clinical                              [   ]
          -----------------------------------------------------
          Non-clinical                          [   ]
          -----------------------------------------------------

In addition, project-related travel and expenses will be reimbursed by the
Sponsor at cost.

(c) Additional items priced on request:

i.    Rights to use variance information in product research, development or
      marketing.
ii.   Milestones and royalties for successful completion of projects
      incorporating variance use rights.

----------
(9) For calculation of project prices on an hourly basis, these minimum bid
prices per FTE per year can be converted to hourly rates based on 2080 hours per
FTE per year, such that minimum bid prices for Clinical and Non-clinical PTEs
will be [           ] per hour, respectively.


                                                                               2
<PAGE>

Exhibit A: Price Schedule for Alliance Programs

3. Variance Detection

(a) Provided to Sponsor:

Clinical trial laboratory testing for known genetic variances as part of a
Sponsor clinical trial:

i.    Genomic samples will be prepared from whole blood or established cell
      lines and tested for variances in selected genes as specified in the
      Sponsor's clinical trial protocol.
ii.   Any necessary custom genetic assays will be developed or accessed.
iii.  When necessary, tests will be performed in a manner that is suitable for
      submission to international regulatory bodies.
iv.   Results may be reported on a concurrent basis and a clean laboratory data
      file will be provided for integration into the primary clinical data
      package for analysis.

(b) Minimum prices (10):

<TABLE>
<CAPTION>
---------------------------------------------------------------------------------------
Clinical Trial Laboratory
Testing Services             Minimum Bid Price    Comments
---------------------------------------------------------------------------------------
<S>                           <C>                 <C>
Assay Development             $[    ] per gene     [     ]
and Validation
---------------------------------------------------------------------------------------

Genetic Tests and             $[  ] per test       [     ]
Results Reporting
---------------------------------------------------------------------------------------
Sample Collection,            $[  ] per patient    Patient kits, sample handling and
Preparation and Handling                           tracking, DNA extraction.
---------------------------------------------------------------------------------------
</TABLE>

Study management services related to variance detection will be priced as
described under pharmacogenomic services. In addition, project-related travel
and expenses will be reimbursed by the Sponsor at cost.

(c) Additional items priced on request:

i.    Discovery of novel genetic variances.
ii.   Development of assays and testing for cDNA haplotypes of selected genes.
iii.  Sequencing of genes for all genetic variations, including new, unknown
      variances.
iv.   Assays for number of gene copies, including gene deletions, and gene
      expression.
v.    Special sample preparation and handling requirements, such as RNA
      stabilization or lymphocyte immortalization.
vi.   Specialized collection, preparation and handling of patient tissue samples
      other than whole blood or established cell lines.
vii.  Extended sample storage or DNA banking.
viii. Statistical analyses of associations between genotypes and phenotypes.

----------
(10) These prices apply only to Variance Detection performed by Variagenics. As
agreed above, Variagenics may engage contractors, including Quintiles
Laboratories, Inc., to perform variance detection. In this event, prices paid to
such contractors, as negotiated by Variagenics, [   ], unless otherwise agreed.


                                                                               3
<PAGE>

Exhibit A: Price Schedule for Alliance Programs

4. Variance Use Rights

(a) Provided to Sponsor(11):
i.    Non-exclusive licenses to use Variances in specified genes for studies
      related to a specified pharmaceutical product in an Alliance Program for a
      period of one year, with an option to renew the licenses annually.
      Continued renewal of a license to use Variances in a gene will prevent the
      grant of rights to a third party that will limit or terminate rights under
      the license.

ii.   Option to purchase, on commercially reasonable terms to be negotiated in
      good faith, exclusive or co-exclusive rights within the specified
      pharmaceutical product's therapeutic class, as available, to use Variances
      in a gene.

(b) Minimum prices:
Non-exclusive rights to use Variances will be provided for [        ].

                 ----------------------------------------------
                 Non-Exclusive               Minimum Bid Price
                 Use Rights                 ($000 per Year)(12)
                 ----------------------------------------------
                 Program Fee per Drug               [  ]
                 ----------------------------------------------
                 Use Fee per Gene                   [  ]
                 ----------------------------------------------

In addition, Variagenics will negotiate in good faith with the Sponsor
reasonable lump sum payments to be paid contingent upon successfully achieving
milestones related to the use of Variances at different stages of the
pharmaceutical product development and approval process.

Upon submission of information related to Variances used to a regulatory body in
an application (including supplementary materials) for approval of a
pharmaceutical product, or a labeling claim related to the use of that
pharmaceutical product, the Sponsor and Variagenics agree to negotiate in good
faith for Variagenics to provide to the Sponsor, on commercially reasonable
terms and as available, non-exclusive rights to market the pharmaceutical
product based on information related to the Variances used.

(c) Additional items priced on request:

i.    Advance purchase of non-exclusive rights to market a pharmaceutical
      product based on information related to Variances used, with or without
      royalties payable on product sales.
ii.   Exclusive, co-exclusive or permanent use rights.
iii.  Rights to use variances outside Alliance Programs.
iv.   Rights to market diagnostic or disease management products or services
      based on Variances.
v.    Rights to use technologies other than genetic variances.

----------
(11) A standard license agreement with detailed terms will be prepared,
maintained and approved by Variagenics.

(12) Licenses may be discontinued with ninety (90) days advance notice. Upon
discontinuation, fees will be pro-rated to the time of termination and any
prepaid amounts will be refunded to the Sponsor.


                                                                               4
<PAGE>

Exhibit A: Price Schedule for Alliance Programs

5. Price Quotations

Unless otherwise requested by a Sponsor, prices will be quoted on a fully
bundled basis and will not be specifically itemized. Prices for Variance Use
Rights may be quoted separately. At the request of a Sponsor, prices may be
itemized by major category (Variance Discovery and Database, Pharmacogenomics
Services, Variance Detection) without prior approval by Variagenics. Any further
itemization of prices within major categories requires prior approval by
Variagenics. All prices will be payable to Variagenics in United States Dollars
(US$) and Quintiles will be responsible for conversion to US$ of any payments
made in other currencies.

6. Discounts from Bid Prices

As necessary to respond to market conditions, including competitive bids, and
only if the Sponsor specifically requests a price reduction, discounts up to
[  ]% off these minimum bid prices may be offered and accepted by Quintiles
without prior approval by Variagenics. Discounts up to an additional [  ]% of
these bid prices may be offered and accepted by Quintiles, at Quintiles'
expense, without prior approval by Variagenics. In such cases, the price
payable to Variagenics (and the price used to calculate Qualifying Program
Revenues) will represent [  ]% of the minimum bid price, and Quintiles will
be responsible for paying to Variagenics the amount of any additional
discounts provided to the Sponsor. Approval by Variagenics will be required
prior to offer or acceptance by Quintiles of any discounts greater than [  ]%
off the minimum bid prices.

7. Payment Timing for Unilateral Alliance Programs

For Unilateral Alliance Programs, which do not qualify for an advance of
revenues by Quintiles to Variagenics, the following minimum payment timing terms
will apply:

--------------------------------------------------------------------------------
                                Minimum Upfront Payment   Minimum Final Payment
Product Component                     Bid (Accept)             Bid (Accept)
--------------------------------------------------------------------------------
Variance Discovery                    [ ]% ([ ]%)               [ ]% ([ ]%)
and Database
--------------------------------------------------------------------------------
Pharmacogenomic Services              [ ]% ([ ]%)               [ ]% ([ ]%)
--------------------------------------------------------------------------------
Variance Detection                    [ ]% ([ ]%)               [ ]% ([ ]%)
--------------------------------------------------------------------------------
Variance Use Rights(13)               [ ]% ([ ]%)               [ ]% ([ ]%)
--------------------------------------------------------------------------------

Payments are expressed as a percent of the total contract value. The remaining
amounts will be paid in equal amounts to be evenly spread between initiation and
completion of services performed by Variagenics.

----------
(13) Payment terms for annual fees only, excluding any downstream payments such
as milestones or royalties.


                                                                               5