UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D
.C
. 20460 

## 'JUL 1 5 2011

MEMORANDUM OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION



### SUBJECT: 

### BEAD Chemical Profile for Registration Review: Acetaminophen (109509)
FROM:

THRU:

TO: 

### Colwell Cook, Entomologist

## d~ Biological Analysis Branch Sepehr Haddad, Environmental Protection Specialist Science Information and Analysis Branch Michelle Ranville, Economist 

# Lf}LCAC) Economic Analysis Branch Biological and Economic Analysis Division (7503P) ArnetJones, Chief /)

# ""J~ Biological Analysis

# Branc**~**

# ""U
Diann Sims, Chief

# ~~ pM,[) 

### Science Information and Analysis Branch Timothy Kiely, Chief

# ~**~** Economic Analysis Branch 

# VV\. Biological and Economic Analysi ivision (7 ) Bonnie Adler, Chemical Review Manager Risk Management and Implementation Branch 5 Pesticide Reevaluation Division (7508P)


### Product Review Panel date: July 13, 2011
INTRODUCTION 

### The purpose ofthis document is to convey usage information and a broad overview ofthe pest management roles ofpesticides that are beginning to undergo registration review. The anticipated audience consists ofthe team ofEPA staffcurrently evaluating the registration status ofacetaminophen, and eventually the general pUblic. This document builds upon the data already 1provided in the "Usage and Label Use Data Packages" that are also provided to Registration Reviewteams byBEAD. The document is based on information and data available to BEAD as ofJune 2011. Acetaminophen (the same ingredient found in Tylenol®) is an analgesic and antipyretic drug for humans, and sometimes considered to be a non-steroidal anti-inflammatory drug. 

### It was found to be toxic to the brown treesnake, 

### Boiga irregularis , an invasive species currently in Guam. The exact mode ofaction is unknown. Acetaminophen was registered for brown treesnake control in February 2004 in an application by the USDA APHIS. The brown treesnake is an introduced, invasive species in Guam. Itis mildly venomous, fairly aggressive, and a dietary generalist that have decimated many native bird species on Guam. This pesticide is one part ofan IPM program developed by the United States Department of Agriculture Wildlife Services to reduce the populations ofbrown snakes. (Johnson, et al., 2002) USE SITES NOD- 

### Agricultural Usage Acetaminophen for brown tree snake control is labeled for use in non-crop areas in and around military bases, airports, shipping ports, and other areas where brown tree snakes may be present. This registration is for use only by employees ofthe U.S. State and Federal governments, Government ofGuam orthe Commonwealth ofNorthern Mariana Islands trained in brown treesnake control.
COMMON FORMULATIONS AND APPLICATION METHODS Acetaminophen is formulated as a pelletted solid only. Baitpreparation is by manually inserting one 80 mg ortwo 40 mg acetaminophen tablets into the throat ofa dead mOuse pup (approximate age: 10-15 days). Baits may be broadcast or dropped from helicopters and fixed wing aircraft:.
BIOLOGICAL ASPECTS RELEVANT TO ACETAMINOPHEN There are no other uses ofacetaminophen as a pesticide, and the dose used is equivalent to the children's dose. Therefore, BEAD does not foresee are any issues concerning resistance, plant health claims, orpublic health issues.
HISTORY OF BEAD ASSESSMENTS FORACETAMINOPHEN No other BEAD assessments were found in the official records.

2REFERENCES J. J. Johnston, P. J. Savarie, T. M. Primus, J. D. Eisemann, J. C l-Iurley, and D. J. Kohler 

### Environ. Sci. Technol
., 2002, 36 (17), pp 3827-3833 

### RiskAssessment of anAcetaminophen BaitingProgram for Chemical Control of Brown Tree Snakes on Guam: Evaluation of Baits, Snake Residues, andPotential Primary and Secondary Hazards http://pubs
.acs.org/doi/fullli0.1021/esO15873n

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