# Patent

## Title
Genetic markers of schizophrenia endophenotypes

## Abstract

This document provides methods and materials related to genetic markers of schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD), (collectively referred to herein as “schizophrenia spectrum disorders” or SSDs). For example, methods for using such genetic markers to identify an SSD (e.g., SZ) endophenotype are provided.

## Background
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation of International Patent Application No. PCT/US2009/058483, filed Sep. 25, 2009, which claims priority to U.S. Provisional Application Ser. No. 61/100,176, filed on Sep. 25, 2008, which are incorporated by reference in their entirety herein.


FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
This invention was made with government support under Grant Nos. R43 MH078437, N01 MH900001, and MH074027, awarded by National Institutes of Health. The government has certain rights in the invention.


TECHNICAL FIELD
This document provides methods and materials related to genetic markers of endophenotypes of schizophrenia (SZ), schizotypal personality disorder (SPD), and/or schizoaffective disorder (SD), (collectively referred to herein as “schizophrenia spectrum disorders” or SSDs). For example, this document provides methods for using such genetic markers to identify an SSD (e.g., SZ) endophenotype in a subject.
BACKGROUND
The schizophrenia spectrum disorders include schizophrenia (SZ), schizotypal personality disorder (SPD), and schizoaffective disorder (SD). Schizophrenia (SZ) is considered a clinical syndrome, and is probably a constellation of several pathologies. Substantial heterogeneity is seen between cases, which is thought to reflect multiple overlapping etiologic factors, including both genetic and environmental contributions. SD is characterized by the presence of affective (depressive or manic) symptoms and schizophrenic symptoms within the same, uninterrupted episode of illness. SPD is characterized by a pervasive pattern of social and interpersonal deficits marked by acute discomfort with, and reduced capacity for, close relationships as well as by cognitive or perceptual distortions and eccentricities of behavior, beginning by early adulthood and present in a variety of contexts.
Endophenotypes are quantitative, continuously distributed traits, symptoms or disease dimensions s typically assessed by laboratory-based methods or clinical observation. The use of endophenotypes allows complex psychiatric illnesses like SZ to be divided into more stable, readily definable categories that are more amendable to identification of clear genetic associations, as they are generally more reflective of specific underlying biological processes. Identifying the genetic basis of specific endophenotypes also facilitates identification and development of new drugs that target the specific physiological deficits underlying disease. See Braff et al., Schiz. Bull. 33(1):21-32 (2007).
SUMMARY
This disclosure provides methods of determining severity of SZ endophenotypes in subjects diagnosed with SZ based on genetic variants in genes involved in a number of pathways including: glutamate signaling and metabolism, cell adhesion, cytoskeletal architecture, vesicle formation, and trafficking, G-protein coupled receptors, carrier proteins and transporters, cell cycle modulators, neuronal development, calcium/calmodulin signaling, neuropeptide signaling, and several additional genes identified by virtue of their interaction with genes in high impact pathways and their expression in the central nervous system. This disclosure provides methods and claims relating to determining the severity of an SSD endophenotype according to a subject's underlying genetic architecture. As described herein, methods for determining severity of an SSD endophenotype include evaluation of SNPs for genes relating to endophenotypes in SSDs including SZ, SPD, and SD.
In one aspect, this document features methods for determining a severity of a schizophrenia (SZ) endophenotype in a human subject. Methods can include determining the identity of an allele of at least one single nucleotide polymorphism (SNP) listed in Tables 1-3 in the subject; comparing the identity of the allele in the subject with a reference allele, wherein the reference allele is associated with a severity of a specific endophenotype; and determining the severity of the endophenotype in the subject, based on the comparison of the allele in the subject to the reference allele; thereby determining the severity of the schizophrenia endophenotype in the subject.
In another aspect, this document features methods for selecting a treatment for schizophrenia in a human subject. Methods can include determining the identity of an allele of at least one polymorphism listed in Tables 1-3 in the subject; comparing the identity of the allele in the subject with a reference allele, wherein the reference allele is associated with a severity of a specific endophenotype; determining the severity of the endophenotype in the subject, based on the comparison of the allele in the subject to the reference allele; and selecting a treatment for the subject based on the determined severity of the specific schizophrenia endophenotype for the subject.
A SZ endophenotype can be a quantitative trait that can be measured using one or more of PANSS Total composite score, PANSS Positive composite score, PANSS Negative composite score, and PANSS General Psychopathology composite score. A SZ endophenotype can be a quantitative trait that can be measured using the PANSS Total composite score and the polymorphism can be at position 31 of a sequence selected from the group consisting of SEQ ID NOs:417, 1471, 704, 419, 1602, 1401, and 1076. A SZ endophenotype can be a quantitative trait that can be measured using the PANSS Positive composite score and the polymorphism can be at position 31 of a sequence selected from the group consisting of SEQ ID NOs:1364, 1562, 534, and 1754. A SZ endophenotype can be a quantitative trait that can be measured using the PANSS Total composite score and the polymorphism can be at position 31 of a sequence selected from the group consisting of SEQ ID NOs:1504, 1401, 275, 165, and 129. A SZ endophenotype can be a quantitative trait that can be measured using the PANSS Total composite score and the polymorphism can be at position 31 of a sequence selected from the group consisting of SEQ ID NOs:688, 1882, 1751, and 1285.
A schizophrenia endophenotype can include one or more of: a Positive Symptom selected from the group consisting of P1—delusions, P2—conceptual disorganization, P3—hallucinatory behavior, P4—excitement, P5—grandiosity, P6—suspiciousness, P7—hostility; a Negative Symptom selected from the group consisting of N1—blunted affect, N2—emotional withdrawal, N3—poor rapport, N4—passive/apathetic social withdrawal, N5—difficulty in abstract thinking, N6—lack of spontaneity and flow of conversation, N7—stereotyped thinking; or a general psychopathology symptom selected from the group consisting of G1—somatic concern, G2—anxiety, G3—guilt feelings, G4—tension, G5—mannerisms and posturing, G6—depression, G7—motor retardation, G8—uncooperativeness, G9—unusual thought content, G10—disorientation, G11—poor attention, G12—lack of judgment and insight, G13—disturbance of volition, G14—poor impulse control, G15—preoccupation, and G16—active social avoidance.
Determining the identity of an allele can include obtaining a sample comprising DNA from the subject, and determining identity of the nucleotide at the polymorphic site. Determining the identity of the nucleotide can include contacting the sample with a probe specific for a selected allele of the polymorphism, and detecting the formation of complexes between the probe and the selected allele of the polymorphism, wherein the formation of complexes between the probe and the test marker indicates the presence of the selected allele in the sample. Determining the identity of an allele can include determining the identity of the nucleotide at position 31 of one of SEQ ID NOs: 1-1894. A reference allele can represent an allele in a subject or subjects who have a known severity of the endophenotype.
A subject can be a patient, i.e., a human patient, having or suspected of having SZ. A subject can have one or more risk factors associated with SZ. Risk factors associated with SZ can include one or more of: a relative afflicted with a schizophrenia spectrum disorder (SSD); and a genetically based phenotypic trait associated with risk for a SSD. Methods can further include selecting or excluding a subject for enrollment in a clinical trial based on the identity of the allele. Methods can further include stratifying a subject population for analysis of a clinical trial based on the identity of the allele in the subjects. Methods can further include confirming a severity of a SZ endophenotype using psychometric instruments. Methods can further include administering the selected treatment to the subject. A selected treatment can be an anti-psychotic drug, an anti-depressant drug, anti-anxiety drug, mood stabilizer, selective serotonin reuptake inhibitor (SSRI), psychotherapy, or a stimulant. A treatment can be a combination of an anti-psychotic drug, plus one or more of an anti-depressant drug, anti-anxiety drug, mood stabilizer, selective serotonin reuptake inhibitor (SSRI), psychotherapy, or a stimulant. A treatment can be psychotherapy. Methods can further include recording the identity of the allele in a tangible medium. A tangible medium can include a computer-readable disk, a solid state memory device, or an optical storage device.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Although methods and materials similar or equivalent to those described herein can be used to practice the invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting.
The details of one or more embodiments of the invention are set forth in the accompanying drawings and the description below. Other features, objects, and advantages of the invention will be apparent from the description and drawings, and from the claims.


DETAILED DESCRIPTION
This document provides methods for determining severity of an endophenotype in a patient diagnosed with SZ based on evaluation of single nucleotide polymorphisms (SNPs) for genes relating to endophenotypes of SSDs including schizophrenia (SZ), schizotypal personality disorder (SPD), and schizoaffective disorder (SD). As described herein, bioinformatic and genetic analyses provided evidence of association of the disclosed SNP alleles with severity of intermediate phenotypes, or “endophenotypes,” in patients diagnosed with SZ.
Definitions
As used herein, an “endophenotype” is a quantitative psychiatric trait exhibited by patients diagnosed with SZ. One way that such traits can be measured is by clinical assessment made by administering the Positive and Negative Syndrome Scale (PANSS) (Kay et al., Schizophr. Bull. 13:261-276 (1987); Kay et al., Br. J. Psychiatry Suppl 59-67 (1989); Leucht et al., Schizophr. Res. 79:231-238 (2005)).
As used herein, an “allele” is one of a pair or series of genetic variants of a polymorphism at a specific genomic location. An “endophenotypic allele” is an allele that is statistically associated with severity of a specific endophenotype.
A “haplotype” is one or a set of signature genetic changes (polymorphisms) that are normally grouped closely together on the DNA strand, and are usually inherited as a group; the polymorphisms are also referred to herein as “markers.” A “haplotype” as used herein is information regarding the presence or absence of one or more genetic markers in a given chromosomal region in a subject. A haplotype can consist of a variety of genetic markers, including indels (insertions or deletions of the DNA at particular locations on the chromosome); single nucleotide polymorphisms (SNPs) in which a particular nucleotide is changed; microsatellites; and minisatellites.
Microsatellites (sometimes referred to as a variable number of tandem repeats or VNTRs) are short segments of DNA that have a repeated sequence, usually about 2 to 5 nucleotides long (e.g., CACACA), that tend to occur in non-coding DNA. Changes in the microsatellites sometimes occur during the genetic recombination of sexual reproduction, increasing or decreasing the number of repeats found at an allele, changing the length of the allele. Microsatellite markers are stable, polymorphic, easily analyzed and occur regularly throughout the genome, making them especially suitable for genetic analysis.
“Copy number variation” (CNV), as used herein, refers to variation from the normal diploid condition for a gene or polymorphism. Individual segments of human chromosomes can be deleted or duplicated such that the subject's two chromosome carry fewer than two copies of the gene or polymorphism (a deletion or deficiency) or two or more copies (a duplication).
“Linkage disequilibrium” refers to when the observed frequencies of haplotypes in a population does not agree with haplotype frequencies predicted by multiplying together the frequency of individual genetic markers in each haplotype.
The term “chromosome” as used herein refers to a gene carrier of a cell that is derived from chromatin and comprises DNA and protein components (e.g., histones). The conventional internationally recognized individual human genome chromosome numbering identification system is employed herein. The size of an individual chromosome can vary from one type to another with a given multi-chromosomal genome and from one genome to another. In the case of the human genome, the entire DNA mass of a given chromosome is usually greater than about 100,000,000 base pairs. For example, the size of the entire human genome is about 3×109 base pairs.
The term “gene” refers to a DNA sequence in a chromosome that codes for a product (either RNA or its translation product, a polypeptide). A gene contains a coding region and includes regions preceding and following the coding region (termed respectively “leader” and “trailer”). The coding region is comprised of a plurality of coding segments (“exons”) and intervening sequences (“introns”) between individual coding segments.
The term “probe” refers to an oligonucleotide. A probe can be single stranded at the time of hybridization to a target. As used herein, probes include primers, i.e., oligonucleotides that can be used to prime a reaction, e.g., a PCR reaction.
The term “label” or “label containing moiety” refers in a moiety capable of detection, such as a radioactive isotope or group containing same, and nonisotopic labels, such as enzymes, biotin, avidin, streptavidin, digoxygenin, luminescent agents, dyes, haptens, and the like. Luminescent agents, depending upon the source of exciting energy, can be classified as radioluminescent, chemiluminescent, bioluminescent, and photoluminescent (including fluorescent and phosphorescent). A probe described herein can be bound, e.g., chemically bound to label-containing moieties or can be suitable to be so bound. The probe can be directly or indirectly labeled.
The term “direct label probe” (or “directly labeled probe”) refers to a nucleic acid probe whose label after hybrid formation with a target is detectable without further reactive processing of hybrid. The term “indirect label probe” (or “indirectly labeled probe”) refers to a nucleic acid probe whose label after hybrid formation with a target is further reacted in subsequent processing with one or more reagents to associate therewith one or more moieties that finally result in a detectable entity.
The terms “target,” “DNA target,” or “DNA target region” refers to a nucleotide sequence that occurs at a specific chromosomal location. Each such sequence or portion is preferably at least partially, single stranded (e.g., denatured) at the time of hybridization. When the target nucleotide sequences are located only in a single region or fraction of a given chromosome, the term “target region” is sometimes used. Targets for hybridization can be derived from specimens which include, but are not limited to, chromosomes or regions of chromosomes in normal, diseased or malignant human cells, either interphase or at any state of meiosis or mitosis, and either extracted or derived from living or postmortem tissues, organs or fluids; germinal cells including sperm and egg cells, or cells from zygotes, fetuses, or embryos, or chorionic or amniotic cells, or cells from any other germinating body; cells grown in vitro, from either long-term or short-term culture, and either normal, immortalized or transformed; inter- or intraspecific hybrids of different types of cells or differentiation states of these cells; individual chromosomes or portions of chromosomes, or translocated, deleted or other damaged chromosomes, isolated by any of a number of means known to those with skill in the art, including libraries of such chromosomes cloned and propagated in prokaryotic or other cloning vectors, or amplified in vitro by means well known to those with skill; or any forensic material, including but not limited to blood, or other samples.
The term “hybrid” refers to the product of a hybridization procedure between a probe and a target.
The term “hybridizing conditions” has general reference to the combinations of conditions that are employable in a given hybridization procedure to produce hybrids, such conditions typically involving controlled temperature, liquid phase, and contact between a probe (or probe composition) and a target. Conveniently and preferably, at least one denaturation step precedes a step wherein a probe or probe composition is contacted with a target. Guidance for performing hybridization reactions can be found in Ausubel et al., Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (2003), 6.3.1-6.3.6. Aqueous and nonaqueous methods are described in that reference and either can be used. Hybridization conditions referred to herein are a 50% formamide, 2×SSC wash for 10 minutes at 45° C. followed by a 2×SSC wash for 10 minutes at 37° C.
Calculations of “identity” between two sequences can be performed as follows. The sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second nucleic acid sequence for optimal alignment and non-identical sequences can be disregarded for comparison purposes). The length of a sequence aligned for comparison purposes is at least 30% (e.g., at least 40%, 50%, 60%, 70%, 80%, 90% or 100%) of the length of the reference sequence. The nucleotides at corresponding nucleotide positions are then compared. When a position in the first sequence is occupied by the same nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences.
The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. In some embodiments, the percent identity between two nucleotide sequences is determined using the GAP program in the GCG software package, using a Blossum 62 scoring matrix with a gap penalty of 12, a gap extend penalty of 4, and a frameshift gap penalty of 5.
As used herein, the term “substantially identical” is used to refer to a first nucleotide sequence that contains a sufficient number of identical nucleotides to a second nucleotide sequence such that the first and second nucleotide sequences have similar activities. Nucleotide sequences that are substantially identical are at least 80% (e.g., 85%, 90%, 95%, 97% or more) identical.
The term “nonspecific binding DNA” refers to DNA which is complementary to DNA segments of a probe, which DNA occurs in at least one other position in a genome, outside of a selected chromosomal target region within that genome. An example of nonspecific binding DNA comprises a class of DNA repeated segments whose members commonly occur in more than one chromosome or chromosome region. Such common repetitive segments tend to hybridize to a greater extent than other DNA segments that are present in probe composition.
Methods of Determining the Degree of Specific Endophenotypes
Quantitative traits, by definition, are measured by degree rather than simply presence or absence, like blood glucose or cholesterol. The genetically-based methods described herein can give a biological indication of the degree (or severity) of a phenotype a patient might show, and not be dependent upon the results of a particular psychiatric test done on one particular day. This is similar to testing for LDL receptor variants to understand why a person might have high cholesterol and how it would be best to treat the patient, rather than simply looking at cholesterol levels. In the SZ context, this is particularly important since a subject's presentation of disease may vary from day to day. For example, a subject with SZ may display more mania one day than the next; if a medical professional evaluates them on a day when they are displaying fewer symptoms of mania, an inappropriate treatment plan might be prepared.
Described herein are a variety of methods for identifying, predicting, or determining severity or degree of a subject's SSD (e.g., SZ) endophenotype. “Severity” includes the whole spectrum of expression of the endophenotype, including both positive and negative scores on the PANSS test, e.g., extremely severe expression to mild or substantially no expression of the endophenotype. As used herein, determining severity or degree of an SSD endophenotype is based on the presence or absence of one or more alleles associated with severity of the endophenotypes in patients diagnosed with SZ as described herein. Ascertaining whether the subject has such an allele is included in the concept of determining SSD (e.g., SZ) endophenotypes as used herein. The presence an allele associated with a particular severity indicates a specific genetic (biological) contribution to the particular endophenotype. Such contributions can be positive (tending to increase the degree of the endophenotype) or negative (tending to decrease the degree of the endophenotype) depending on the specific allele of the polymorphism.
As used herein, “determining the identity of an allele” includes obtaining information regarding the identity, presence or absence of one or more specific alleles in a subject. Determining the identity of an allele can, but need not, include obtaining a sample comprising DNA from a subject, and/or assessing the identity, presence or absence of one or more genetic markers in the sample. The individual or organization who determines the identity of the allele need not actually carry out the physical analysis of a sample from a subject; the methods can include using information obtained by analysis of the sample by a third party. Thus the methods can include steps that occur at more than one site. For example, a sample can be obtained from a subject at a first site, such as at a health care provider, or at the subject's home in the case of a self-testing kit. The sample can be analyzed at the same or a second site, e.g., at a laboratory or other testing facility.
Determining the identity of an allele can also include or consist of reviewing a subject's medical history, where the medical history includes information regarding the identity, presence or absence of one or more response alleles in the subject, e.g., results of a genetic test.
In some embodiments, to determine the identity of an allele described herein, a biological sample that includes nucleated cells (such as blood, a cheek swab or mouthwash) is prepared and analyzed for the presence or absence of preselected markers. Such diagnoses may be performed by diagnostic laboratories, or, alternatively, diagnostic kits can be manufactured and sold to health care providers or to private individuals for self-diagnosis. Diagnostic or prognostic tests can be performed as described herein or using well known techniques, such as described in U.S. Pat. No. 5,800,998.
Results of these tests, and optionally interpretive information, can be returned to the subject, the health care provider or to a third party payor. The results can be used in a number of ways. The information can be, e.g., communicated to the tested subject, e.g., with a prognosis and optionally interpretive materials that help the subject understand the test results and prognosis. The information can be used, e.g., by a health care provider, to determine whether to administer a specific drug, or whether a subject should be assigned to a specific category, e.g., a category associated with a specific disease endophenotype, or with drug response or non-response. The information can be used, e.g., by a third party payor such as a healthcare payer (e.g., insurance company or HMO) or other agency, to determine whether or not to reimburse a health care provider for services to the subject, or whether to approve the provision of services to the subject. For example, the healthcare payer may decide to reimburse a health care provider for treatments for an SSD if the subject has a particular response allele. As another example, a drug or treatment may be indicated for individuals with a certain allele, and the insurance company would only reimburse the health care provider (or the insured individual) for prescription or purchase of the drug if the insured individual has that response allele. The presence or absence of the response allele in a patient may be ascertained by using any of the methods described herein.
Alleles Associated with Severity of SSD Endophenotypes
This document provides methods for determining the degree of an SSD (e.g., SZ) endophenotype based on evaluation of single nucleotide polymorphisms (SNPs) for genes relating to endophenotypes of SZ-spectrum disorders including schizophrenia (SZ), schizotypal personality disorder (SPD), and schizoaffective disorder (SD). The alleles described herein can be used both to determine patients who are likely to display higher or lower values for specific endophenotypes and to determine the contribution of genetic makeup and specific biological/cellular pathways to specific endophenotypes and severity thereof. Tables 1-3 and Table A list specific SNPs, variation of which is associated with variations in severity of specific endophenotypes. One of skill in the art will appreciate that other variants can be identified via TDT using families with multiple affected individuals or by Case/Control comparisons using the SNP markers presented herein. Using SNP markers that are identical to or in linkage disequilibrium with the exemplary SNPs, one can determine other alleles, including haplotypes and single SNP alleles in these genes relating response to an endophenotype of an SSD (e.g., of SZ). The allelic variants thus identified can be used equivalently to the exemplary SNPs, e.g., to determine a diagnosis of a specific endophenotype in a patient.
Markers in Linkage disequilibrium (LD)
Linkage disequilibrium (LD) is a measure of the degree of association between alleles in a population. One of skill in the art will appreciate that alleles involving markers in LD with the polymorphisms described herein can also be used in a similar manner to those described herein. Methods of calculating LD are known in the art (see, e.g., Morton et al., Proc. Natl. Acad. Sci. USA 98(9):5217-21 (2001); Tapper et al., Proc. Natl. Acad. Sci. USA 102(33):11835-11839 (2005); Maniatis et al., Proc. Natl. Acad. Sci. USA 99:2228-2233 (2002)). Thus, in some cases, the methods can include analysis of polymorphisms that are in LD with a polymorphism described herein. Methods are known in the art for identifying such polymorphisms; for example, the International HapMap Project provides a public database that can be used, see hapmap.org, as well as The International HapMap Consortium, Nature 426:789-796 (2003), and The International HapMap Consortium, Nature 437:1299-1320 (2005). Generally, it will be desirable to use a HapMap constructed using data from individuals who share ethnicity with the subject. For example, a HapMap for African Americans would ideally be used to identify markers in LD with an exemplary marker described herein for use in genotyping a subject of African American descent.
Alternatively, methods described herein can include analysis of polymorphisms that show a correlation coefficient (r2) of value ≧0.5 with the markers described herein. Results can be obtained from on line public resources such as HapMap.org on the World Wide Web. The correlation coefficient is a measure of LD, and reflects the degree to which alleles at two loci (for example, two SNPs) occur together, such that an allele at one SNP position can predict the correlated allele at a second SNP position, in the case where r2 is >0.5.
Identifying Additional Genetic Markers
In general, genetic markers can be identified using any of a number of methods well known in the art. For example, numerous polymorphisms in the regions described herein are known to exist and are available in public databases, which can be searched using methods and algorithms known in the art. Alternately, polymorphisms can be identified by sequencing either genomic DNA or cDNA in the region in which it is desired to find a polymorphism. According to one approach, primers are designed to amplify such a region, and DNA from a subject is obtained and amplified. The DNA is sequenced, and the sequence (referred to as a “subject sequence” or “test sequence”) is compared with a reference sequence, which can represent the “normal” or “wild type” sequence, or the “affected” sequence. In some embodiments, a reference sequence can be from, for example, the human draft genome sequence, publicly available in various databases, or a sequence deposited in a database such as GenBank In some embodiments, the reference sequence is a composite of ethnically diverse individuals.
In general, if sequencing reveals a difference between the sequenced region and the reference sequence, a polymorphism has been identified. The fact that a difference in nucleotide sequence is identified at a particular site that determines that a polymorphism exists at that site. In most instances, particularly in the case of SNPs, only two polymorphic variants will exist at any location. However, in the case of SNPs, up to four variants may exist since there are four naturally occurring nucleotides in DNA. Other polymorphisms, such as insertions and deletions, may have more than four alleles.
The methods described herein can also include determining the presence or absence of other markers known or suspected to be associated with an SSD (e.g., SZ) endophenotype, e.g., markers outside of a region identified herein, see, e.g., Harrison and Owen, Lancet, 361(9355):417-419 (2003). In some embodiments, the methods include determining the presence or absence of one or more other markers that are or may be associated with an SSD (e.g., SZ) endophenotype, e.g., in one or more genes, e.g., e.g., as described in WO 2009/092032, WO 2009/089120, WO 2009/082743, US2006/0177851, and US2009/0012371 incorporated herein in their entirety. See also, e.g., OMIM entry no. 181500 (SCZD).
Methods of Determining the Identity of an Allele
The methods described herein include determining the identity, presence or absence of alleles associated with a severity of specific SSD (e.g., SZ) endophenotype. In some cases, an association with severity of an SSD (e.g., SZ) endophenotype is determined by the presence of the same allele in both the subject and an affected reference individual, e.g., in an unrelated reference subject or a first or second-degree relation of the subject, and the absence of the allele in an unaffected reference individual. Thus the methods can include obtaining and analyzing a sample from a suitable reference individual. Samples that are suitable for use in the methods described herein contain genetic material, e.g., genomic DNA (gDNA). Genomic DNA is typically extracted from biological samples such as blood or mucosal scrapings of the lining of the mouth, but can be extracted from other biological samples including urine or expectorant. The sample itself will typically include nucleated cells (e.g., blood or buccal cells) or tissue removed from the subject. The subject can be an adult, child, fetus, or embryo. In some embodiments, the sample is obtained prenatally, either from a fetus or embryo or from the mother (e.g., from fetal or embryonic cells in the maternal circulation). Methods and reagents are known in the art for obtaining, processing, and analyzing samples. In some embodiments, the sample is obtained with the assistance of a health care provider, e.g., to draw blood. In some embodiments, the sample is obtained without the assistance of a health care provider, e.g., where the sample is obtained non-invasively, such as a sample comprising buccal cells that is obtained using a buccal swab or brush, or a mouthwash sample.
In some cases, a biological sample may be processed for DNA isolation. For example, DNA in a cell or tissue sample can be separated from other components of the sample. Cells can be harvested from a biological sample using standard techniques known in the art. For example, cells can be harvested by centrifuging a cell sample and resuspending the pelleted cells. The cells can be resuspended in a buffered solution such as phosphate-buffered saline (PBS). After centrifuging the cell suspension to obtain a cell pellet, the cells can be lysed to extract DNA, e.g., gDNA. See, e.g., Ausubel et al., 2003, supra. The sample can be concentrated and/or purified to isolate DNA. All samples obtained from a subject, including those subjected to any sort of further processing, are considered to be obtained from the subject. Routine methods can be used to extract genomic DNA from a biological sample, including, for example, phenol extraction. Alternatively, genomic DNA can be extracted with kits such as the QIAamp® Tissue Kit (Qiagen, Chatsworth, Calif.) and the Wizard® Genomic DNA purification kit (Promega). Non-limiting examples of sources of samples include urine, blood, and tissue.
The absence or presence of an allele associated with severity of an SSD (e.g., SZ) endophenotype as described herein can be determined using methods known in the art. For example, gel electrophoresis, capillary electrophoresis, size exclusion chromatography, sequencing, and/or arrays can be used to detect the presence or absence of the allele. Amplification of nucleic acids, where desirable, can be accomplished using methods known in the art, e.g., PCR. In one example, a sample (e.g., a sample comprising genomic DNA), is obtained from a subject. The DNA in the sample is then examined to determine the identity of an allele as described herein. The identity of the allele can be determined by any method described herein, e.g., by sequencing or by hybridization of the gene in the genomic DNA, RNA, or cDNA to a nucleic acid probe, e.g., a DNA probe (which includes cDNA and oligonucleotide probes) or an RNA probe. The nucleic acid probe can be designed to specifically or preferentially hybridize with a particular polymorphic variant.
Other methods of nucleic acid analysis can include direct manual sequencing (Church and Gilbert, Proc. Natl. Acad. Sci. USA 81:1991-1995 (1988); Sanger et al., Proc. Natl. Acad. Sci. USA 74:5463-5467 (1977); Beavis et al., U.S. Pat. No. 5,288,644); automated fluorescent sequencing; single-stranded conformation polymorphism assays (SSCP) (Schafer et al., Nat. Biotechnol. 15:33-39 (1995)); clamped denaturing gel electrophoresis (CDGE); two-dimensional gel electrophoresis (2DGE or TDGE); conformational sensitive gel electrophoresis (CSGE); denaturing gradient gel electrophoresis (DGGE) (Sheffield et al., Proc. Natl. Acad. Sci. USA 86:232-236 (1989)); denaturing high performance liquid chromatography (DHPLC, Underhill et al., Genome Res. 7:996-1005 (1997)); infrared matrix-assisted laser desorption/ionization (IR-MALDI) mass spectrometry (WO 99/57318); mobility shift analysis (Orita et al., Proc. Natl. Acad. Sci. USA 86:2766-2770 (1989)); restriction enzyme analysis (Flavell et al., Cell 15:25 (1978); Geever et al., Proc. Natl. Acad. Sci. USA 78:5081 (1981)); quantitative real-time PCR (Raca et al., Genet Test 8(4):387-94 (2004)); heteroduplex analysis; chemical mismatch cleavage (CMC) (Cotton et al., Proc. Natl. Acad. Sci. USA 85:4397-4401 (1985)); RNase protection assays (Myers et al., Science 230:1242 (1985)); use of polypeptides that recognize nucleotide mismatches, e.g., E. coli mutS protein; allele-specific PCR, and combinations of such methods. See, e.g., Gerber et al., U.S. Patent Publication No. 2004/0014095 which is incorporated herein by reference in its entirety.
Sequence analysis can also be used to detect specific polymorphic variants. For example, polymorphic variants can be detected by sequencing exons, introns, 5′ untranslated sequences, or 3′ untranslated sequences. A sample comprising DNA or RNA is obtained from the subject. PCR or other appropriate methods can be used to amplify a portion encompassing the polymorphic site, if desired. The sequence is then ascertained, using any standard method, and the presence of a polymorphic variant is determined. Real-time pyrophosphate DNA sequencing is yet another approach to detection of polymorphisms and polymorphic variants (Alderborn et al., Genome Research 10(8):1249-1258 (2000)). Additional methods include, for example, PCR amplification in combination with denaturing high performance liquid chromatography (dHPLC) (Underhill et al., Genome Research 7(10):996-1005 (1997)).
In order to detect polymorphisms and/or polymorphic variants, it will frequently be desirable to amplify a portion of genomic DNA (gDNA) encompassing the polymorphic site. Such regions can be amplified and isolated by PCR using oligonucleotide primers designed based on genomic and/or cDNA sequences that flank the site. PCR refers to procedures in which target nucleic acid (e.g., genomic DNA) is amplified in a manner similar to that described in U.S. Pat. No. 4,683,195, and subsequent modifications of the procedure described therein. Generally, sequence information from the ends of the region of interest or beyond are used to design oligonucleotide primers that are identical or similar in sequence to opposite strands of a potential template to be amplified. See e.g., PCR Primer: A Laboratory Manual, Dieffenbach and Dveksler, (Eds.); McPherson et al., PCR Basics: From Background to Bench (Springer Verlag, 2000); Mattila et al., Nucleic Acids Res., 19:4967 (1991); Eckert et al., PCR Methods and Applications, 1:17 (1991); PCR (eds. McPherson et al., IRL Press, Oxford); and U.S. Pat. No. 4,683,202. Other amplification methods that may be employed include the ligase chain reaction (LCR) (Wu and Wallace, Genomics 4:560 (1989), Landegren et al., Science 241:1077 (1988), transcription amplification (Kwoh et al., Proc. Natl. Acad. Sci. USA 86:1173 (1989)), self-sustained sequence replication (Guatelli et al., Proc. Nat. Acad. Sci. USA 87:1874 (1990)), and nucleic acid based sequence amplification (NASBA). Guidelines for selecting primers for PCR amplification are well known in the art. See, e.g., McPherson et al., PCR Basics: From Background to Bench, Springer-Verlag, 2000. A variety of computer programs for designing primers are available, e.g., ‘Oligo’ (National Biosciences, Inc, Plymouth Minn.), MacVector (Kodak/IBI), and the GCG suite of sequence analysis programs (Genetics Computer Group, Madison, Wis. 53711).
In some cases, PCR conditions and primers can be developed that amplify a product only when the variant allele is present or only when the wild type allele is present (MSPCR or allele-specific PCR). For example, patient DNA and a control can be amplified separately using either a wild type primer or a primer specific for the variant allele. Each set of reactions is then examined for the presence of amplification products using standard methods to visualize the DNA. For example, the reactions can be electrophoresed through an agarose gel and the DNA visualized by staining with ethidium bromide or other DNA intercalating dye. In DNA samples from heterozygous patients, reaction products would be detected in each reaction.
Real-time quantitative PCR can also be used to determine copy number. Quantitative PCR permits both detection and quantification of specific DNA sequence in a sample as an absolute number of copies or as a relative amount when normalized to DNA input or other normalizing genes. A key feature of quantitative PCR is that the amplified DNA product is quantified in real-time as it accumulates in the reaction after each amplification cycle. Methods of quantification can include the use of fluorescent dyes that intercalate with double-stranded DNA, and modified DNA oligonucleotide probes that fluoresce when hybridized with a complementary DNA.
In some embodiments, a peptide nucleic acid (PNA) probe can be used instead of a nucleic acid probe in the hybridization methods described above. PNA is a DNA mimetic with a peptide-like, inorganic backbone, e.g., N-(2-aminoethyl)glycine units, with an organic base (A, G, C, T or U) attached to the glycine nitrogen via a methylene carbonyl linker (see, e.g., Nielsen et al., Bioconjugate Chemistry, The American Chemical Society, 5:1 (1994)). The PNA probe can be designed to specifically hybridize to a nucleic acid comprising a polymorphic variant indicative of an SSD (e.g., SZ) endophenotype.
In some cases, allele-specific oligonucleotides can also be used to detect the presence of a polymorphic variant. For example, polymorphic variants can be detected by performing allele-specific hybridization or allele-specific restriction digests. Allele specific hybridization is an example of a method that can be used to detect sequence variants, including complete haplotypes of a subject (e.g., a mammal such as a human). See Stoneking et al., Am. J. Hum. Genet. 48:370-382 (1991); and Prince et al., Genome Res. 11:152-162 (2001). An “allele-specific oligonucleotide” (also referred to herein as an “allele-specific oligonucleotide probe”) is an oligonucleotide that is specific for particular a polymorphism can be prepared using standard methods (see Ausubel et al., Current Protocols in Molecular Biology, supra). Allele-specific oligonucleotide probes typically can be approximately 10-50 base pairs, preferably approximately 15-30 base pairs, that specifically hybridizes to a nucleic acid region that contains a polymorphism. Hybridization conditions are selected such that a nucleic acid probe can specifically bind to the sequence of interest, e.g., the variant nucleic acid sequence. Such hybridizations typically are performed under high stringency as some sequence variants include only a single nucleotide difference. In some cases, dot-blot hybridization of amplified oligonucleotides with allele-specific oligonucleotide (ASO) probes can be performed. See, for example, Saiki et al., Nature (London) 324:163-166 (1986).
In some embodiments, allele-specific restriction digest analysis can be used to detect the existence of a polymorphic variant of a polymorphism, if alternate polymorphic variants of the polymorphism result in the creation or elimination of a restriction site. Allele-specific restriction digests can be performed in the following manner. A sample containing genomic DNA is obtained from the individual and genomic DNA is isolated for analysis. For nucleotide sequence variants that introduce a restriction site, restriction digest with the particular restriction enzyme can differentiate the alleles. In some cases, polymerase chain reaction (PCR) can be used to amplify a region comprising the polymorphic site, and restriction fragment length polymorphism analysis is conducted (see Ausubel et al., Current Protocols in Molecular Biology, supra). The digestion pattern of the relevant DNA fragment indicates the presence or absence of a particular polymorphic variant of the polymorphism and is therefore indicative of severity of an SSD endophenotype. For sequence variants that do not alter a common restriction site, mutagenic primers can be designed that introduce a restriction site when the variant allele is present or when the wild type allele is present. For example, a portion of a nucleic acid can be amplified using the mutagenic primer and a wild type primer, followed by digest with the appropriate restriction endonuclease.
In some embodiments, fluorescence polarization template-directed dye-terminator incorporation (FP-TDI) is used to determine which of multiple polymorphic variants of a polymorphism is present in a subject (Chen et al., Genome Research 9(5):492-498 (1999)). Rather than involving use of allele-specific probes or primers, this method employs primers that terminate adjacent to a polymorphic site, so that extension of the primer by a single nucleotide results in incorporation of a nucleotide complementary to the polymorphic variant at the polymorphic site.
In some cases, DNA containing an amplified portion may be dot-blotted, using standard methods (see Ausubel et al., Current Protocols in Molecular Biology, supra), and the blot contacted with the oligonucleotide probe. The presence of specific hybridization of the probe to the DNA is then detected. Specific hybridization of an allele-specific oligonucleotide probe to DNA from the subject can be indicative of the presence of an allele associated with an SSD (e.g., SZ) endophenotype.
The methods can include determining the genotype of a subject with respect to both copies of the polymorphic site present in the genome. For example, the complete genotype may be characterized as −/−, as −/+, or as +/+, where a minus sign indicates the presence of the reference or wild type sequence at the polymorphic site, and the plus sign indicates the presence of a polymorphic variant other than the reference sequence. If multiple polymorphic variants exist at a site, this can be appropriately indicated by specifying which ones are present in the subject. Any of the detection means described herein can be used to determine the genotype of a subject with respect to one or both copies of the polymorphism present in the subject's genome.
Methods of nucleic acid analysis to detect polymorphisms and/or polymorphic variants can include, e.g., microarray analysis. Hybridization methods, such as Southern analysis, Northern analysis, or in situ hybridizations, can also be used (see Ausubel et al., Current Protocols in Molecular Biology, eds., John Wiley & Sons (2003)). To detect microdeletions, fluorescence in situ hybridization (FISH) using DNA probes that are directed to a putatively deleted region in a chromosome can be used. For example, probes that detect all or a part of a microsatellite marker can be used to detect microdeletions in the region that contains that marker.
In some embodiments, it is desirable to employ methods that can detect the presence of multiple polymorphisms (e.g., polymorphic variants at a plurality of polymorphic sites) in parallel or substantially simultaneously. Oligonucleotide arrays represent one suitable means for doing so. Other methods, including methods in which reactions (e.g., amplification, hybridization) are performed in individual vessels, e.g., within individual wells of a multi-well plate or other vessel may also be performed so as to detect the presence of multiple polymorphic variants (e.g., polymorphic variants at a plurality of polymorphic sites) in parallel or substantially simultaneously according to the methods provided herein.
Nucleic acid probes can be used to detect and/or quantify the presence of a particular target nucleic acid sequence within a sample of nucleic acid sequences, e.g., as hybridization probes, or to amplify a particular target sequence within a sample, e.g., as a primer. Probes have a complimentary nucleic acid sequence that selectively hybridizes to the target nucleic acid sequence. In order for a probe to hybridize to a target sequence, the hybridization probe must have sufficient identity with the target sequence, i.e., at least 70% (e.g., 80%, 90%, 95%, 98% or more) identity to the target sequence. The probe sequence must also be sufficiently long so that the probe exhibits selectivity for the target sequence over non-target sequences. For example, the probe will be at least 20 (e.g., 25, 30, 35, 50, 100, 200, 300, 400, 500, 600, 700, 800, 900 or more) nucleotides in length. In some embodiments, the probes are not more than 30, 50, 100, 200, 300, 500, 750, or 1000 nucleotides in length. Probes are typically about 20 to about 1×106 nucleotides in length. Probes include primers, which generally refers to a single-stranded oligonucleotide probe that can act as a point of initiation of template-directed DNA synthesis using methods such as PCR (polymerase chain reaction), LCR (ligase chain reaction), etc., for amplification of a target sequence.
The probe can be a test probe such as a probe that can be used to detect polymorphisms in a region described herein (e.g., polymorphisms as described herein). In some embodiments, the probe can bind to another marker sequence associated with SZ, SPD, or SD as described herein.
Control probes can also be used. For example, a probe that binds a less variable sequence, e.g., repetitive DNA associated with a centromere of a chromosome, can be used as a control. Probes that hybridize with various centromeric DNA and locus-specific DNA are available commercially, for example, from Vysis, Inc. (Downers Grove, Ill.), Molecular Probes, Inc. (Eugene, Oreg.), or from Cytocell (Oxfordshire, UK). Probe sets are available commercially such from Applied Biosystems, e.g., the Assays-on-Demand SNP kits Alternatively, probes can be synthesized, e.g., chemically or in vitro, or made from chromosomal or genomic DNA through standard techniques. For example, sources of DNA that can be used include genomic DNA, cloned DNA sequences, somatic cell hybrids that contain one, or a part of one, human chromosome along with the normal chromosome complement of the host, and chromosomes purified by flow cytometry or microdissection. The region of interest can be isolated through cloning, or by site-specific amplification via the polymerase chain reaction (PCR). See, for example, Nath and Johnson, Biotechnic. Histochem. 73(1):6-22 (1998); Wheeless et al., Cytometry 17:319-326 (1994); and U.S. Pat. No. 5,491,224.
In some embodiments, the probes are labeled, e.g., by direct labeling, with a fluorophore, an organic molecule that fluoresces after absorbing light of lower wavelength/higher energy. A directly labeled fluorophore allows the probe to be visualized without a secondary detection molecule. After covalently attaching a fluorophore to a nucleotide, the nucleotide can be directly incorporated into the probe with standard techniques such as nick translation, random priming, and PCR labeling. Alternatively, deoxycytidine nucleotides within the probe can be transaminated with a linker. The fluorophore then is covalently attached to the transaminated deoxycytidine nucleotides. See, e.g., U.S. Pat. No. 5,491,224.
Fluorophores of different colors can be chosen such that each probe in a set can be distinctly visualized. For example, a combination of the following fluorophores can be used: 7-amino-4-methylcoumarin-3-acetic acid (AMCA), TEXAS REDTM (Molecular Probes, Inc., Eugene, Oreg.), 5-(and -6)-carboxy-X-rhodamine, lissamine rhodamine B, 5-(and -6)-carboxyfluorescein, fluorescein-5-isothiocyanate (FITC), 7-diethylaminocoumarin-3-carboxylic acid, tetramethylrhodamine-5-(and -6)-isothiocyanate, 5-(and -6)-carboxytetramethylrhodamine, 7-hydroxycoumarin-3-carboxylic acid, 6-[fluorescein 5-(and -6)-carboxamido]hexanoic acid, N-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a diaza-3-indacenepropionic acid, eosin-5-isothiocyanate, erythrosin-5-isothiocyanate, and CASCADETM blue acetylazide (Molecular Probes, Inc., Eugene, Oreg.). Fluorescently labeled probes can be viewed with a fluorescence microscope and an appropriate filter for each fluorophore, or by using dual or triple band-pass filter sets to observe multiple fluorophores. See, for example, U.S. Pat. No. 5,776,688. Alternatively, techniques such as flow cytometry can be used to examine the hybridization pattern of the probes. Fluorescence-based arrays are also known in the art.
In other embodiments, the probes can be indirectly labeled with, e.g., biotin or digoxygenin, or labeled with radioactive isotopes such as 32P and 3H. For example, a probe indirectly labeled with biotin can be detected by avidin conjugated to a detectable marker. For example, avidin can be conjugated to an enzymatic marker such as alkaline phosphatase or horseradish peroxidase. Enzymatic markers can be detected in standard colorimetric reactions using a substrate and/or a catalyst for the enzyme. Catalysts for alkaline phosphatase include 5-bromo-4-chloro-3-indolylphosphate and nitro blue tetrazolium. Diaminobenzoate can be used as a catalyst for horseradish peroxidase.
In another aspect, this document features arrays that include a substrate having a plurality of addressable areas, and methods of using them. At least one area of the plurality includes a nucleic acid probe that binds specifically to a sequence comprising a polymorphism listed in any of Tables 1-3, and can be used to detect the absence or presence of said polymorphism, e.g., one or more SNPs, microsatellites, minisatellites, or indels, as described herein, to determine the identity of an allele. For example, the array can include one or more nucleic acid probes that can be used to detect a polymorphism listed in any of Tables 1-3. In some embodiments, the array further includes at least one area that includes a nucleic acid probe that can be used to specifically detect another marker associated with severity of an SSD (e.g., SZ), as described herein. In some embodiments, the probes are nucleic acid capture probes.
Generally, microarray hybridization is performed by hybridizing a nucleic acid of interest (e.g., a nucleic acid encompassing a polymorphic site) with the array and detecting hybridization using nucleic acid probes. In some cases, the nucleic acid of interest is amplified prior to hybridization. Hybridization and detecting are generally carried out according to standard methods. See, e.g., Published PCT Application Nos. WO 92/10092 and WO 95/11995, and U.S. Pat. No. 5,424,186. For example, the array can be scanned to determine the position on the array to which the nucleic acid hybridizes. The hybridization data obtained from the scan is typically in the form of fluorescence intensities as a function of location on the array.
Arrays can be formed on substrates fabricated with materials such as paper, glass, plastic (e.g., polypropylene, nylon, or polystyrene), polyacrylamide, nitrocellulose, silicon, optical fiber, or any other suitable solid or semisolid support, and can be configured in a planar (e.g., glass plates, silicon chips) or three dimensional (e.g., pins, fibers, beads, particles, microtiter wells, capillaries) configuration. Methods for generating arrays are known in the art and include, e.g., photolithographic methods (see, e.g., U.S. Pat. Nos. 5,143,854; 5,510,270; and 5,527,681), mechanical methods (e.g., directed-flow methods as described in U.S. Pat. No. 5,384,261), pin-based methods (e.g., as described in U.S. Pat. No. 5,288,514), and bead-based techniques (e.g., as described in PCT US/93/04145). The array typically includes oligonucleotide hybridization probes capable of specifically hybridizing to different polymorphic variants. Oligonucleotide probes that exhibit differential or selective binding to polymorphic sites may readily be designed by one of ordinary skill in the art. For example, an oligonucleotide that is perfectly complementary to a sequence that encompasses a polymorphic site (i.e., a sequence that includes the polymorphic site, within it or at one end) will generally hybridize preferentially to a nucleic acid comprising that sequence, as opposed to a nucleic acid comprising an alternate polymorphic variant.
Oligonucleotide probes forming an array may be attached to a substrate by any number of techniques, including, without limitation, (i) in situ synthesis (e.g., high-density oligonucleotide arrays) using photolithographic techniques; (ii) spotting/printing at medium to low density on glass, nylon or nitrocellulose; (iii) by masking, and (iv) by dot-blotting on a nylon or nitrocellulose hybridization membrane. Oligonucleotides can be immobilized via a linker, including by covalent, ionic, or physical linkage. Linkers for immobilizing nucleic acids and polypeptides, including reversible or cleavable linkers, are known in the art. See, for example, U.S. Pat. No. 5,451,683 and WO98/20019. Alternatively, oligonucleotides can be non-covalently immobilized on a substrate by hybridization to anchors, by means of magnetic beads, or in a fluid phase such as in microtiter wells or capillaries. Immobilized oligonucleotide probes are typically about 20 nucleotides in length, but can vary from about 10 nucleotides to about 1000 nucleotides in length.
Arrays can include multiple detection blocks (i.e., multiple groups of probes designed for detection of particular polymorphisms). Such arrays can be used to analyze multiple different polymorphisms. Detection blocks may be grouped within a single array or in multiple, separate arrays so that varying conditions (e.g., conditions optimized for particular polymorphisms) may be used during the hybridization. For example, it may be desirable to provide for the detection of those polymorphisms that fall within G-C rich stretches of a genomic sequence, separately from those falling in A-T rich segments. General descriptions of using oligonucleotide arrays for detection of polymorphisms can be found, for example, in U.S. Pat. Nos. 5,858,659 and 5,837,832. In addition to oligonucleotide arrays, cDNA arrays may be used similarly in certain embodiments.
The methods described herein can include providing an array as described herein; contacting the array with a sample (e.g., all or a portion of genomic DNA that includes at least a portion of a human chromosome comprising a response allele) and/or optionally, a different portion of genomic DNA (e.g., a portion that includes a different portion of one or more human chromosomes), and detecting binding of a nucleic acid from the sample to the array. Optionally, the method includes amplifying nucleic acid from the sample, e.g., genomic DNA that includes a portion of a human chromosome described herein, and, optionally, a region that includes another region associated with a diagnosis of an SSD, severity of an SZ endophenotype, or a predicted response to a method of treating SZ, SD, or SPD, prior to or during contact with the array.
In some aspects, the methods described herein can include using an array that can ascertain differential expression patterns or copy numbers of one or more genes in samples from normal and affected individuals (see, e.g., Redon et al., Nature 444(7118):444-54 (2006)). For example, arrays of probes to a marker described herein can be used to measure polymorphisms between DNA from a subject having a known severity of an SSD (e.g., SZ) endophenotype, and control DNA, e.g., DNA obtained from an individual that does not have an SSD (e.g., SZ) endophenotype, or has a different severity of the SSD (e.g., SZ) endophenotype. Since the clones on the array contain sequence tags, their positions on the array are accurately known relative to the genomic sequence. Different hybridization patterns between DNA from an individual afflicted with a severe SSD (e.g., SZ) endophenotype and DNA from a normal individual (or an individual with SZ not displaying the endophenotype, or displaying a more or less severe degree of the endophenotype) at areas in the array corresponding to markers as described herein, indicate the severity of the endophenotype. Methods for array production, hybridization, and analysis are described, e.g., in Snijders et al., Nat. Genetics 29:263-264 (2001); Klein et al., Proc. Natl. Acad. Sci. USA 96:4494-4499 (1999); Albertson et al., Breast Cancer Research and Treatment 78:289-298 (2003); and Snijders et al., “BAC microarray based comparative genomic hybridization,” in: Zhao et al. (eds), Bacterial Artificial Chromosomes: Methods and Protocols, Methods in Molecular Biology, Humana Press, 2002.
In another aspect, this document provides methods of determining the absence or presence of one or more alleles associated with severity of an SSD (e.g., SZ) endophenotype as described herein, using an array described above. The methods can include providing a two dimensional array having a plurality of addresses, each address of the plurality being positionally distinguishable from each other address of the plurality having a unique nucleic acid capture probe, contacting the array with a first sample from a test subject, and comparing the binding of the first sample with one or more references, e.g., binding of a sample from a subject who has a known severity of an SSD (e.g., SZ) endophenotype, and/or binding of a sample from a subject who has a different known severity of the endophenotype, e.g., is unaffected, e.g., a control sample from a subject who has SZ but displays the endophenotype to a more or less severe degree. In some embodiments, the methods can include contacting the array with a second sample from a subject who has a known severity of an SSD (e.g., SZ) endophenotype; and comparing the binding of the first sample with the binding of the second sample. In some embodiments, the methods can include contacting the array with a third sample from a cell or subject that does not display an SSD (e.g., SZ) endophenotype (e.g., a low score); and comparing the binding of the first sample with the binding of the third sample. In some embodiments, the second and third samples are from first or second-degree relatives of the test subject. In the case of a nucleic acid hybridization, binding with a capture probe at an address of the plurality, can be detected by any method known in the art, e.g., by detection of a signal generated from a label attached to the nucleic acid.
Schizophrenia Spectrum Disorders
The methods described herein can be used to determine severity of an endophenotype of a schizophrenia spectrum disorder (SSD) in an individual diagnosed with the SSD. The SSDs include schizophrenia (SZ), schizotypal personality disorder (SPD), and schizoaffective disorder (SD). Methods for diagnosing SSDs are known in the art, see, e.g., the Diagnostic and Statistical Manual of Mental Disorders—Fourth Edition (“DSM-IV”). See, e.g., WO 2009/092032, incorporated herein by reference.
Psychiatric Endophenotypes
A number of endophenotypes, i.e., intermediate phenotypes, that may more closely reflect biological mechanisms behind SZ, have been suggested, such as prepulse inhibition, structural abnormalities evident in MRI scans, specific domains of cognition (e.g., executive function), fine motor performance, and working memory, inter alia.
Endophenotypes also can include clinical manifestations such as hallucinations, paranoia, mania, depression, obsessive-compulsive symptoms, etc., as well as response or lack of response to drugs and comorbidity for substance and alcohol abuse. See, e.g., Kendler et al., Am J Psychiatry 152(5):749-54 (1995); Gottesman and Gould, Am J Psychiatry 160(4):636-45 (2003); Cadenhead, Psychiatric Clinics of North America 25(4):837-53 (2002); Heinrichs, Neuroscience & Biobehavioral Reviews 28(4):379-94 (2004); and Zobel and Maier, Nervenarzt. 75(3):205-14 (2004). There is now evidence that some candidate genes that were identified using DSM-IV type categorical definitions for “affected” individuals may influence specific endophenotypes, see, e.g., Baker et al., Biol Psychiatry 58(1):23-31 (2005); Cannon et al., Arch Gen Psychiatry 62(11):1205-13 (2005); Gothelf et al., Nat Neurosci 8(11):1500-2 (2005); Hallmayer et al., Am J Hum Genet 77(3):468-76 (2005); Callicott et al., Proc Natl Acad Sci USA 102(24):8627-32 (2005); Gornick et al., J Autism Dev Disord 1-8 (2005). Thus, the methods described herein can be used to associate alleles with specific psychiatric endophenotypes.
Positive and Negative Syndrome Scale (PANSS)
The Positive and Negative Syndrome Scale (PANSS) is a comprehensive psychometric scale used to classify psychopathology for severe neuropsychiatric diseases, including SZ. It measures a number of psychiatric endophenotypes or dimensions using quantitative scales based on the scoring of patients by clinicians. It is widely used to classify patients into specific subtypes, and is commonly used for measuring the improvement of symptoms in response to clinical interventions (Kay et al., Schizophr. Bull. 13:261-276 (1987); Kay et al., Br. J. Psychiatry Suppl 59-67 (1989); Leucht et al., Schizophr. Res. 79:231-238 (2005)).
PANSS comprises 30 individual subscales. Seven constitute a Positive Symptom Scale, seven make up a Negative Symptom Scale, and the remaining 16 items make up a General Psychopathology Scale. The scores for these scales are arrived at by summation of ratings across component items. Therefore, the potential ranges are 7 to 49 for the Positive and Negative Scales, and 16 to 112 for the General Psychopathology Scale (Source: The PANSS Institute). Detailed information on PANSS and Scoring Criteria can be found at www.panss.org or in the book Positive and Negative Syndromes in Schizophrenia, Stanley R. Kay, 1991, ISBN: 978-0-87630-608-6, Routledge, which is incorporated herein in its entirety by reference. Based on these sources, the methodology is summarized briefly below.
Each of the 30 items is accompanied by a specific definition as well as detailed anchoring criteria for all seven rating points. These seven points represent increasing levels of psychopathology, as follows:
1—absent
2—minimal
3—mild
4—moderate
5—moderate severe
6—severe
7—extreme
The individual PANSS Individual subscales are described below.
P1. DELUSIONS—Beliefs which are unfounded, unrealistic and idiosyncratic.
P2. CONCEPTUAL DISORGANIZATION—Disorganized process of thinking characterized by disruption of goal-directed sequencing, e.g. circumstantiality, loose associations, tangentiality, gross illogicality or thought block.
P3. HALLUCINATORY BEHAVIOR—Verbal report or behavior indicating perceptions which are not generated by external stimuli. These may occur in the auditory, visual, olfactory or somatic realms.
P4. EXCITEMENT—Hyperactivity as reflected in accelerated motor behavior, heightened responsivity to stimuli, hypervigilance or excessive mood lability.
P5. GRANDIOSITY—Exaggerated self-opinion and unrealistic convictions of superiority, including delusions of extraordinary abilities, wealth, knowledge, fame, power and moral righteousness.
P6. SUSPICIOUSNESS/PERSECUTION—Unrealistic or exaggerated ideas of persecution, as reflected in guardedness, ad distrustful attitude, suspicious hypervigilance or frank delusions that others mean harm.
P7. HOSTILITY—Verbal and nonverbal expressions of anger and resentment, including sarcasm, passive-aggressive behavior, verbal abuse and assualtiveness.
N1. BLUNTED AFFECT—Diminished emotional responsiveness as characterized by a reduction in facial expression, modulation of feelings and communicative gestures.
N2. EMOTIONAL WITHDRAWAL—Lack of interest in, involvement with, and affective commitment to life's events.
N3. POOR RAPPORT—Lack of interpersonal empathy, openness in conversation and sense of closeness, interest or involvement with the interviewer. This is evidenced by interpersonal distancing and reduced verbal and nonverbal communication.
N4. PASSIVE/APATHETIC SOCIAL WITHDRAWAL—Diminished interest and initiative in social interactions due to passivity, apathy, anergy or avolition. This leads to reduced interpersonal involvements and neglect of activities of daily living.
N5. DIFFICULTY IN ABSTRACT THINKING—Impairment in the use of the abstract-symbolic mode of thinking, as evidenced by difficulty in classification, forming generalizations and proceeding beyond concrete or egocentric thinking in problem-solving tasks.
N6. LACK OF SPONTANEITY AND FLOW OF CONVERSATION—Reduction in the normal flow of communication associated with apathy, avolition, defensiveness or cognitive deficit. This is manifested by diminished fluidity and productivity of the verbal interactional process.
N7. STEREOTYPED THINKING—Decreased fluidity, spontaneity and flexibility of thinking, as evidenced in rigid, repetitious or barren thought content.
G1. SOMATIC CONCERN—Physical complaints or beliefs about bodily illness or malfunctions. This may range from a vague sense of ill being to clear-cut delusions of catastrophic physical disease.
G2. ANXIETY—Subjective experience of nervousness, worry, apprehension or restlessness, ranging from excessive concern about the present or future to feelings of panic.
G3. GUILT FEELINGS—Sense of remorse or self-blame for real or imagined misdeeds in the past.
G4. TENSION—Overt physical manifestations of fear, anxiety, and agitation, such as stiffness, tremor, profuse sweating and restlessness.
G5. MANNERISMS AND POSTURING—Unnatural movements or posture as characterized be an awkward, stilted, disorganized, or bizarre appearance.
G6. DEPRESSION—Feelings of sadness, discouragement, helplessness and pessimism.
G7. MOTOR RETARDATION—Reduction in motor activity as reflected in slowing or lessening or movements and speech, diminished responsiveness of stimuli, and reduced body tone.
G8. UNCOOPERATIVENESS—Active refusal to comply with the will of significant others, including the interviewer, hospital staff or family, which may be associated with distrust, defensiveness, stubbornness, negativism, rejection of authority, hostility or belligerence.
G9. UNUSUAL THOUGHT CONTENT—Thinking characterized by strange, fantastic or bizarre ideas, ranging from those which are remote or atypical to those which are distorted, illogical and patently absurd.
G10. DISORIENTATION—Lack of awareness of one's relationship to the milieu, including persons, place and time, which may be due to confusion or withdrawal.
G11. POOR ATTENTION—Failure in focused alertness manifested by poor concentration, distractibility from internal and external stimuli, and difficulty in harnessing, sustaining or shifting focus to new stimuli.
G12. LACK OF JUDGMENT AND INSIGHT—Impaired awareness or understanding of one's own psychiatric condition and life situation. This is evidenced by failure to recognize past or present psychiatric illness or symptoms, denial of need for psychiatric hospitalization or treatment, decisions characterized by poor anticipation or consequences, and unrealistic short-term and long-range planning
G13. DISTURBANCE OF VOLITION—Disturbance in the willful initiation, sustenance and control of one's thoughts, behavior, movements and speech.
G14. POOR IMPULSE CONTROL—Disordered regulation and control of action on inner urges, resulting in sudden, unmodulated, arbitrary or misdirected discharge of tension and emotions without concern about consequences.
G15. PREOCCUPATION—Absorption with internally generated thoughts and feelings and with autistic experiences to the detriment of reality orientation and adaptive behavior.
G16. ACTIVE SOCIAL AVOIDANCE—Diminished social involvement associated with unwarranted fear, hostility, or distrust.
Differential Diagnosis and Optimizing Treatment
Each patient's disease manifestation and process is unique. PANSS provides a structured, objective way of describing the various aspects of psychopathology of a given patient. However, proper implementation of the PANSS requires highly trained personnel to conduct the assessment and to interpret the results, and there is potential for site to site variability, especially outside the research setting. Additionally, PANSS does not allow one to determine genetic (or biological) vs. environmental contributions to psychopathology, or which of the many possible genetic contributions are relevant to a particular patient.
Each of the PANSS composite scales and subscales can be considered a clinical endophenotype. The ability to link genetic profiles to these clinical endophenotypes, as described herein, will enable clinicians to refine a patient's diagnosis and develop a personalized therapeutic strategy for each patient. For example, the C allele of rs3096489, located in the COL25A1 gene, is associated with increased in the Negative Symptom of Increased Difficulty with Abstract Thinking as shown in the regression analysis in Table 2. By identifying these genetic contributions to specific endophenotypes, the physician can create a personalized diagnosis and treatment regime for the patient.
Results of the methods described herein (e.g., identifying a specific allele in a subject), and optionally interpretive information, can be returned to the subject, the health care provider or to a third party payor. The results can be provided, e.g., in the form of a report; thus, the methods can include preparing a report comprising the results of a method described herein, and identifying information regarding the subject, and optionally interpretive information (e.g., information regarding the association of the allele present in the subject with a particular endophenotype).
The results can be used in a number of ways. The information can be, e.g., communicated to the tested subject, e.g., with a diagnosis/prognosis and optionally interpretive materials that help the subject understand the test results and diagnosis/prognosis. The information can be used, e.g., by a health care provider, to determine whether a subject should be assigned to a specific category (e.g., a category associated with a specific disease endophenotype). The information can be used, e.g., by a third party payor such as a healthcare payer (e.g., insurance company or HMO) or other agency, to determine whether or not to reimburse a health care provider for services to the subject, or whether to approve the provision of services to the subject. For example, the healthcare payer may decide to reimburse a health care provider for treatments for SZ, SD, or SPD if the subject has an allele associated with a particular severity of an SSD endophenotype. In some embodiments, the results are used by a health care provider to select, change, or optimize treatment for the subject.
The addition of a genotype/allele profile which details a patient's individual predicted increased or decreased symptom burden for endophenotypes can provide the treating physician with valuable information required to create an enhanced, personalized treatment regimen for the patient. Thus, the methods described herein can be used to select an antipsychotic medication for the subject, according to treatment and clinical methods known in the art. For example, the methods can include selecting clozapine for positive symptom endophenotypes; quetiapine for subjects with hostility and aggression endophenotypes; olanzapine, clozapine, or amilsupride for negative symptom endophenotypes; and glutamate receptor modulators (several are presently in Phase III clinical trials) for cognitive endophenotypes.
Standard treatment regimens for the majority of patients diagnosed as having SZ typically include polypharmacy. See Pickar et al., PLoS ONE 3(9):e3150 (2008). Physicians often add antidepressants, mood stabilizers, and anti-anxiety medications to the customary treatment with antipsychotics. Additionally, non-medication based therapies such as electroconvulsive shock and cognitive behavioral therapy augment the drug treatment. Thus, in addition, the identification of endophenotypes by a method described herein can be used as an objective criterion to optimize selection of a second drug for administration to the subject. For example, if a patient's allele equates to a reference allele that indicates a likely increased burden for depression, the treating physician might choose to augment antipsychotic therapy with antidepressants. Similarly, an allele that indicates increased symptom burden of mania would suggest that the physician add a mood stabilizer to the patient's drug regimen. An allele associated with disorientation, inattention, lack of judgment or insight, preoccupation, or poor impulse control would indicate administration of a drug for ADHD, e.g., a non-stimulant (such as Atomoxetine (Strattera) or modafinil) or a stimulant, e.g., amphetamine methylphenidate (Ritalin, Metadate, Concerta), dextroamphetamine (Dexedrine), mixed amphetamine salts (Adderall), dextromethamphetamine (Desoxyn) or lisdexamfetamine (Vyvanse). Additional exemplary choices of drugs to be used in addition to an antipsychotic for treating a subject identified as having a specific endophenotype are shown below in Table 4. Changes in a patient's PANSS score and clinical endophenotype can be evaluated following the addition or subtraction of medications or non-medication based therapies with the goal of optimizing treatment for that patient. See, e.g., Chung et al., World J Biol Psychiatry 10(2):156-62 (2009); Hori et al., World J Biol Psychiatry August 25 E-Pub: 1-5 (2009); Lipkovich et al., BMC Psychiatry 9:44 (2009); Hwang et al., Int Clin Psychopharmacol 24(4):189-98 (2009).







TABLE 4







Example Treatments for Specific Endophenotypes, e.g.,


in Combination with Anti-Psychotics









Example Drug











Treatment/
Trade



PANSS Item
Drug Class
name
Generic name





P1-delusions
Cognitive





Behavioral





Therapy (CBT)




P2-conceptual 
CBT




disorganization





P3-hallucinatory behavior
CBT




P4-exitement
Mood stabilizer

lithium, valproate,





lamotrigine


P5-grandiosity
Mood stabilizer

lithium, valproate,





lamotrigine


P6-suspiciousness
Anti-anxiety

benzodiazepines


P7-hostility
Anti-anxiety

benzodiazepines


N1-blunted affect
SSRI
Prozac
Fluoxetine



NMDA-R

glycine, d-



agonists

cycloserine, and





d-serine


N2-emotional withdrawal
SSRI
Prozac
Fluoxetine



NMDA-R

glycine, d-



agonists

cycloserine, and





d-serine


N3-poor rapport
SSRI
Prozac
Fluoxetine



NMDA-R

glycine, d-



agonists

cycloserine, and





d-serine


N4-passive/appathetic 
SSRI
Prozac
Fluoxetine


social withdrawal
NMDA-R

glycine, d-



agonists

cycloserine, and





d-serine


N5-difficulty in abstract 
NMDA-R

glycine, d-


thinking
agonists

cycloserine, and





d-serine


N6-lack of spontaneity 
NMDA-R

glycine, d-


and flow of conversation
agonists

cycloserine, and





d-serine


N7-stereotyped thinking
NMDA-R

glycine, d-



agonists

cycloserine, and





d-serine


G1-somatic concern
SNRI
Cymbalta
duloxetine


G2-anxiety
Anti-anxiety

benzodiazepines


G3-guilt feelings
SSRI
Prozac
fluoxetine


G4-tension
Mood stabilizer

lithium, valproate,





lamotrigine


G5-mannerisms and 
Mood stabilizer

lithium, valproate,


posturing


lamotrigine


G6-depression
SSRI
Prozac
Fluoxetine


G7-motor retardation
Dopaminergics




G8-uncooperativeness


Levomepromazine


G9-unusual thought 
CBT




content





G10-disorentation
ADHD
Stratera,
atomoxetine,



treatment
Ritalin
methylphenidate


G11-poor attention
ADHD
Stratera,
atomoxetine,



treatment;
Ritalin
methylphenidate



cholinesterase





inhibitors




G12-lack of judgment 
ADHD
Stratera,
atomoxetine,


and insight
treatment;
Ritalin
methylphenidate



cholinesterase





inhibitors




G13-disturbance of 
cholinesterase




volition
inhibitors




G14-poor impulse control
ADHD
Stratera,
atomoxetine,



treatment;
Ritalin
methylphenidate



beta-blockers





mood

lithium, valproate,



stabilizers,

lamotrigine


G15-preoccupation
ADHD
Stratera,
atomoxetine,



treatment;
Ritalin
methylphenidate



cholinesterase





inhibitors




G16-active social 
CBT;




avoidance.
cholinesterase





inhibitors





SSRI = selective serotonin reuptake inhibitors


SNRI = serotonin-norepinephrine reuptake inhibitor


ADHD = attention deficit hyperactivity disorder






In some cases, a medical or research professional can assess whether a subject has an allele contributing to a clinical endophenotype according to the methods provided herein. Medical professionals can be, for example, doctors, nurses, medical laboratory technologists, and pharmacists. Research professionals can be, for example, principle investigators, research technicians, postdoctoral trainees, and graduate students. A professional can be assisted by (1) determining whether specific polymorphic variants are present in a biological sample from a subject, and (2) communicating information about polymorphic variants to that professional.
Using information about specific polymorphic variants obtained using a method described herein, a medical professional can take one or more actions that can affect patient care. For example, a medical professional can record information in the patient's medical record regarding the presence or absence of an SSD (e.g., SZ) endophenotype. In some cases, a medical professional can record information regarding an SSD (e.g., SZ) endophenotype, or otherwise transform the patient's medical record, to reflect the patient's current medical condition. In some cases, a medical professional can review and evaluate a patient's entire medical record and assess multiple treatment strategies for clinical intervention of a patient's condition.
In some cases, a medical professional can initiate or modify treatment after receiving genetic information regarding endophenotype. In some cases, a medical professional can recommend a change in therapy. In some cases, a medical professional can enroll a patient in a clinical trial for, by way of example, detecting correlations between an allele as described herein and any measurable or quantifiable parameter relating to an endophenotype as described above.
A medical professional can communicate information regarding severity of an SSD (e.g., SZ) endophenotype to a patient or a patient's family. In some cases, a medical professional can provide a patient and/or a patient's family with information regarding SSDs and severity of endophenotype information, including treatment options, prognosis, and referrals to specialists. In some cases, a medical professional can provide a copy of a patient's medical records to a specialist.
A research professional can apply information regarding the presence of alleles associated with a severity of an SSD (e.g., SZ) endophenotype in a subject to advance scientific research. For example, a researcher can compile data on specific polymorphic variants. In some cases, a research professional can obtain information regarding the identity of an allele associated with a specific endophenotype in a subject as described herein to evaluate a subject's enrollment, or continued participation, in a research study or clinical trial. In some cases, a research professional can communicate information regarding a subject's alleles associated with severity of an SSD (e.g., SZ) endophenotype to a medical professional. In some cases, a research professional can refer a subject to a medical professional.
Any appropriate method can be used to communicate information to another person (e.g., a professional). For example, information can be given directly or indirectly to a professional. For example, a laboratory technician can input a patient's polymorphic variant alleles as described herein into a computer-based record. In some cases, information is communicated by making a physical alteration to medical or research records. For example, a medical professional can make a permanent notation or flag a medical record for communicating the risk assessment to other medical professionals reviewing the record. In addition, any type of communication can be used to communicate allelic, genotypic, severity of endophenotype, and/or treatment information. For example, mail, e-mail, telephone, and face-to-face interactions can be used. The information also can be communicated to a professional by making that information electronically available to the professional. For example, the information can be communicated to a professional by placing the information on a computer database such that the professional can access the information. In addition, the information can be communicated to a hospital, clinic, or research facility serving as an agent for the professional.
Articles of Manufacture
Also provided herein are articles of manufacture comprising a probe that hybridizes with a region of human chromosome as described herein and can be used to detect a polymorphism described herein. For example, any of the probes for detecting polymorphisms described herein can be combined with packaging material to generate articles of manufacture or kits. The kit can include one or more other elements including: instructions for use; and other reagents such as a label or an agent useful for attaching a label to the probe. Instructions for use can include instructions for diagnostic applications of the probe for assessing the severity of an SSD (e.g., SZ) endophenotype in a method described herein. Other instructions can include instructions for attaching a label to the probe, instructions for performing in situ analysis with the probe, and/or instructions for obtaining a sample to be analyzed from a subject. In some cases, the kit can include a labeled probe that hybridizes to a region of human chromosome as described herein.
The kit can also include one or more additional reference or control probes that hybridize to the same chromosome or another chromosome or portion thereof that can have an abnormality associated with a particular endophenotype. A kit that includes additional probes can further include labels, e.g., one or more of the same or different labels for the probes. In other embodiments, the additional probe or probes provided with the kit can be a labeled probe or probes. When the kit further includes one or more additional probe or probes, the kit can further provide instructions for the use of the additional probe or probes. Kits for use in self-testing can also be provided. Such test kits can include devices and instructions that a subject can use to obtain a biological sample (e.g., buccal cells, blood) without the aid of a health care provider. For example, buccal cells can be obtained using a buccal swab or brush, or using mouthwash.
Kits as provided herein can also include a mailer (e.g., a postage paid envelope or mailing pack) that can be used to return the sample for analysis, e.g., to a laboratory. The kit can include one or more containers for the sample, or the sample can be in a standard blood collection vial. The kit can also include one or more of an informed consent form, a test requisition form, and instructions on how to use the kit in a method described herein. Methods for using such kits are also included herein. One or more of the forms (e.g., the test requisition form) and the container holding the sample can be coded, for example, with a bar code for identifying the subject who provided the sample.
Databases and Reports
Also provided herein are databases that include a list of polymorphisms as described herein, and wherein the list is largely or entirely limited to polymorphisms identified as useful for determining severity of an SSD (e.g., SZ) endophenotype as described herein. The list is stored, e.g., on a flat file or computer-readable medium. The databases can further include information regarding one or more subjects, e.g., whether a subject is affected or unaffected, clinical information such as endophenotype, age of onset of symptoms, any treatments administered and outcomes (e.g., data relevant to pharmacogenomics, diagnostics or theranostics), and other details, e.g., about the disorder in the subject, or environmental or other genetic factors. The databases can be used to detect correlations between a particular severity of an SSD (e.g., SZ) endophenotype and the information regarding the subject.
The methods described herein can also include the generation of reports, e.g., for use by a patient, care giver, payor, or researcher, that include information regarding a subject's response allele(s), and optionally further information such as treatments administered, treatment history, medical history, predicted response, and actual response. The reports can be recorded in a tangible medium, e.g., a computer-readable disk, a solid state memory device, or an optical storage device.
Engineered Cells and Methods of Screening
Also provided herein are engineered cells that harbor one or more polymorphism described herein, e.g., one or more polymorphisms associated with severity of one or more SSD (e.g., SZ) endophenotypes. Such cells are useful for studying the effect of a polymorphism on physiological function, and for identifying and/or evaluating potential therapeutic agents such as anti-psychotics for the treatment of specific SSD endophenotypes. Methods of using such cells to identify candidate therapeutics for the treatment of SZ are known in the art, e.g., contacting the cells with a test compound and assaying for an effect of the test compound on the cell. The methods can also include detecting an effect of a polymorphism described herein on the activity or levels of a gene or protein associated with that polymorphism, to identify a target for therapeutics.
As one example, included herein are cells in which one of the various alleles of the genes described herein has be re-created that is associated with a particular severity of an SSD (e.g., SZ) endophenotype. Methods are known in the art for generating cells, e.g., by homologous recombination between the endogenous gene and an exogenous DNA molecule introduced into a cell, e.g., a cell of an animal. In some cases, the cells can be used to generate transgenic animals using methods known in the art.
The cells are preferably mammalian cells (e.g., neuronal type cells) in which an endogenous gene has been altered to include a polymorphism as described herein. Techniques such as targeted homologous recombinations, can be used to insert the heterologous DNA as described in, e.g., Chappel, U.S. Pat. No. 5,272,071; WO 91/06667, published in May 16, 1991.
EXAMPLES
The invention is further described in the following examples, which do not limit the scope of the invention described in the claims.
Example 1
Novel Markers Associated with Overall Psychiatric Endophenotypes in SZ
The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE), a large federally funded clinical trial designed to assess the efficacy of antipsychotics in a real world setting, is a valuable resource for determining the role of genes in drug response (Stroup et al., Schizophr. Bull. 29:15-31 (2003); Lieberman et al., N. Engl. J. Med. 353:1209-1223 (2005)). As part of the CATIE trial, SNP genotyping was performed for roughly half of the trial participants (Sullivan et al., Mol. Psychiatry. 13:570-584 (2008)). When combined with disease status, PANSS scores, and clinical drug response data, the genotyping data allows the identification of genetic variants (e.g., SNPs) that are statistically associated with specific endophenotypes.
The design of the CATIE study has been described in detail by others (see, e.g., Stroup et al., Schizophr. Bull. 29:15-31 (2003); Lieberman et al., N. Engl. J. Med. 353:1209-1223 (2005)). Briefly, 1460 subjects were randomly assigned one of several antipsychotics and those who did not respond or chose to quit their current medication were re-randomized to another drug. Details regarding SNP genotyping and quality control have been recently published (Sullivan et al., Mol. Psychiatry. 13:570-584 (2008)).
Genotype and phenotype data for the CATIE trial were made available to qualified researchers through the NIMH Center for Collaborative Genetic Studies on Mental Disorders. Data for 417 patients with schizophrenia and 419 unaffected controls self reported as having exclusively European ancestry were evaluated. This same patient population was described in a recent study by Sullivan and coworkers, which confirmed that there is no hidden stratification in the sample (Sullivan et al., Mol. Psychiatry. 13:570-584 (2008)).
For the CATIE study, individual cases were diagnosed as having SZ based on DSM-III/IV criteria.
Confirmation of SNP Effects on Psychiatric Endophenotypes
Genotype and PANSS phenotype data were evaluated for 417 SZ patients enrolled in the CATIE trial. Following a period of drug wash-out, the CATIE study investigators rated each participant at baseline for psychopathology using the PANSS.
Each of the individual and composite scores is a quantitative trait that can be assessed using quantitative statistical genetics methods. Genetic analysis to determine the influence of haplotypes on quantitative PANSS values was performed using the PLINK 1.03 whole genome analysis toolset developed by Purcell and coworkers (Purcell et al., Am. J. Hum. Genet. 81:559-575 (2007). For dichotomous values, PLINK calculates P values for the allele-specific chi-squared test and the odds ratio (OR; or relative risk) associated with the minor allele. For quantitative values, PLINK performs a linear regression using an additive model for the minor allele.
Tables 1-3 report results for specific SNP alleles that affect quantitative endophenotypes for SZ, along with Beta values and P values for the particular alleles of SNPs listed therein. The Beta, beta weight from the regression, measures the impact of the SNP allele on the particular scale. A positive Beta means that the allele for the test SNP increases the score for that measure of psychopathology by the stated Beta value, while a negative Beta means that the allele for the test SNP decreases the score that for that measure of psychopathology by the stated Beta value.
Table 1 shows selected examples for PANSS Total score, and Table 2 shows selected examples for Positive Symptoms subscale, Negative Symptoms subscale, and the General Psychopathology subscale, analyzed as quantitative traits in PLINK using linear regression.
Table 3 shows selected examples for the individual PANSS components. The component evaluated in each row is identified by one of the following abbreviations: Positive Symptoms: P1—delusions, P2—conceptual disorganization, P3—hallucinatory behavior, P4—excitement, P5—grandiosity, P6—suspiciousness, P7—hostility; Negative Symptoms: N1—blunted affect, N2—emotional withdrawal, N3—poor rapport, N4—passive/apathetic social withdrawal, N5—difficulty in abstract thinking, N6—lack of spontaneity and flow of conversation, N7—stereotyped thinking; General Psychopathology Symptoms: G1—somatic concern, G2—anxiety, G3—guilt feelings, G4-tension, G5—mannerisms and posturing, G6—depression, G7—motor retardation, G8—uncooperativeness, G9—unusual thought content, G10—disorientation, G11—poor attention, G12—lack of judgment and insight, G13 disturbance of volition, G14—poor impulse control, G15—preoccupation, G16—active social avoidance.
Table A lists the chromosome and position for each SNP, by SEQ ID NO.; the genomic position is relative to NCBI Human Genome Reference Assembly Build 36.3.
Other Embodiments
It is to be understood that while the invention has been described in conjunction with the detailed description thereof, the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Other aspects, advantages, and modifications are within the scope of the following claims.







TABLE 1







Alleles Influencing Total PANSS













SEQ ID






Gene
NO:
NCBI RS #
Allele
Beta
P















KIF1B
3
1555849
G
2.66
0.0467


CGN
16
1547832
A
−3.95
0.0421


RALGPS2
32
12076230
G
−3.02
0.0169


USH2A
42
7548730
C
2.92
0.0239


RYR2
66
2779400
A
−2.62
0.0355


CHRM3
69
16838637
G
2.40
0.0397


FMN2
86
10926257
T
5.23
0.0181


AGBL4-C1ORF165
91
319965
A
2.78
0.0262


SCP2
98
3766762
C
−6.05
0.0383


ELTD1
100
17102632
T
3.37
0.0425


HPCAL1
105
16856020
T
4.55
0.0102


NTSR2
108
4669767
C
−2.99
0.0158


RAB3GAP1
112
16831315
C
4.04
0.0490


KYNU
130
10176234
A
2.57
0.0375


ARHGAP15
141
13031917
C
2.65
0.0353


FMNL2
144
2164402
G
−3.03
0.0327


KCNJ3
149
2961962
C
−2.71
0.0244


PKP4
158
2528582
G
−3.43
0.0072


PKP4
159
2711072
C
2.73
0.0354


SCN3A
165
11677254
C
−3.94
0.0018


SCN9A
169
7589835
A
4.64
0.0134


PDE1A
177
13400054
C
−3.25
0.0367


PDE1A
190
9332425
T
−2.50
0.0493


NRP2
203
955395
T
−3.37
0.0064


NRP2
205
6435306
A
−2.70
0.0272


PIP5K3
207
10497899
T
−9.28
0.0055


SAG
220
2304773
A
5.04
0.0106


SAG
221
894100
A
2.74
0.0406


KLHL29
225
6727901
G
−2.60
0.0383


KLHL29
227
7560892
A
−2.50
0.0392


KCNK3
228
7584568
G
−2.55
0.0404


DPYSL5
231
540490
T
2.63
0.0320


DPYSL5
232
3769138
G
2.47
0.0442


SLC8A1
246
417614
A
2.70
0.0427


SLC8A1
247
2072531
T
−2.48
0.0411


SLC8A1
248
417591
G
3.06
0.0352


SLC8A1
249
11885401
C
3.92
0.0329


PLEKHH2
254
2288710
C
5.00
0.0393


C2ORF34
261
1067378
A
−3.54
0.0120


C2ORF34
264
1067402
T
−3.20
0.0284


C2ORF34
265
698792
A
−3.09
0.0330


C2ORF34
266
698823
G
−2.93
0.0318


C2ORF34
267
698827
G
−2.72
0.0467


C2ORF34
275
3738980
C
−4.91
0.0037


PRKCE
277
6748375
C
2.89
0.0155


FBXO11
281
12620679
C
−2.57
0.0379


PSME4
282
805391
T
−3.54
0.0029


ACYP2
287
918357
G
2.62
0.0282


ACYP2
288
12615749
G
−4.46
0.0165


ACYP2
290
17045754
C
−4.22
0.0195


CTNNA2
301
2566539
T
−2.94
0.0297


CTNNA2
302
1971766
A
−2.75
0.0288


CTNNA2
307
895388
T
−4.50
0.0439


CTNNA2
312
6547316
T
2.52
0.0451


DDEF2
316
10204214
T
4.32
0.0174


PLCXD2
320
1513331
C
3.64
0.0362


PLCXD2
323
6784753
C
−2.69
0.0308


KALRN
327
16835912
C
3.37
0.0065


CPNE4
330
10934970
C
6.26
0.0438


CPNE4
331
13319291
G
2.57
0.0419


CPNE4
336
9289395
G
3.12
0.0187


RAB6B
340
6765093
G
3.07
0.0112


CLSTN2
356
9836487
G
2.76
0.0251


CLSTN2
358
4683499
G
2.85
0.0256


SLC7A14
372
6788596
G
−3.22
0.0130


PLD1
377
7633686
G
−4.21
0.0222


HTR3D
385
939334
G
2.63
0.0430


HTR3D
386
6779545
A
3.28
0.0102


IL1RAP
394
6791374
C
−5.85
0.0128


RARB
400
17525900
C
−4.17
0.0416


STAC
413
17186340
T
4.22
0.0484


ULK4
415
1495698
C
3.37
0.0094


ULK4
417
1691966
G
4.37
0.0003


ULK4
419
13069172
G
4.24
0.0004


ERC2
447
885211
A
−2.83
0.0249


FHIT
454
639244
G
3.50
0.0068


FHIT
455
2253211
C
2.64
0.0283


FHIT
456
2121865
T
2.61
0.0359


CADPS
471
13313979
A
−2.74
0.0387


CADPS
474
17280557
A
−3.33
0.0236


CADPS
475
17280571
T
−3.21
0.0187


CADPS
477
11925708
A
−2.91
0.0163


MAGI1
482
2371948
A
7.83
0.0451


GBE1
490
7622741
G
3.30
0.0118


GBE1
491
6769230
A
3.27
0.0133


GBE1
492
2307058
T
2.96
0.0259


GBE1
494
7613144
T
2.90
0.0290


GBE1
498
2680245
A
−2.44
0.0446


HTR1F
500
1027689
T
5.15
0.0121


ANK2
517
29306
G
3.14
0.0233


ANK2
518
29311
A
4.00
0.0040


INPP4B
528
2667101
G
2.61
0.0376


INPP4B
529
2667108
C
8.45
0.0314


INPP4B
532
336329
G
8.45
0.0314


INPP4B
534
2276942
A
4.56
0.0322


POU4F2
538
1979903
C
−5.99
0.0175


FSTL5
543
6825091
A
3.12
0.0229


FSTL5
544
7442468
C
2.85
0.0358


TLL1
557
11942650
G
−6.56
0.0244


PALLD
559
17054309
A
−3.49
0.0344


PALLD
564
3109206
T
−2.74
0.0255


PALLD
565
11930576
C
−2.63
0.0380


PALLD
566
4425335
G
−2.92
0.0417


ODZ3
572
2675532
C
3.79
0.0030


ENPP6
574
6830766
G
−2.79
0.0260


ENPP6
577
4340829
A
−2.65
0.0364


ENPP6
578
6815145
A
−2.57
0.0486


ENPP6
579
17584049
C
−3.47
0.0057


KIAA1239
592
2973226
C
−2.48
0.0387


KIAA1239
593
1382979
A
−2.88
0.0372


LIMCH1
598
4343753
T
3.30
0.0201


NPFFR2
614
17775309
G
−2.83
0.0283


SCARB2
616
17001533
C
−3.95
0.0274


SCD5
621
7684732
C
−3.76
0.0163


SCD5
622
17006038
C
−4.16
0.0121


PDLIM5
632
6812098
C
3.30
0.0380


SLC2A9
643
7671266
T
−3.12
0.0334


FBXL17
646
11242664
G
3.29
0.0410


KCNN2
654
1457762
A
2.56
0.0346


HSD17B4
662
246968
A
−2.49
0.0354


SNX2
669
12109789
G
2.49
0.0444


SNX2
670
10519715
A
3.11
0.0183


SNX24
672
6888023
T
3.11
0.0180


SNX24
673
246286
T
−2.76
0.0328


SNX24
674
246266
C
−2.73
0.0345


DNAH5
686
10513155
A
2.82
0.0289


DNAH5
691
13154455
G
3.35
0.0082


ODZ2
704
2337017
C
−6.04
0.0004


ODZ2
707
7714651
A
−4.53
0.0148


ODZ2
708
1421989
G
−5.09
0.0015


ODZ2
711
6868169
G
2.88
0.0246


CDH10
722
3822429
T
−3.57
0.0032


SLC45A2
723
35388
T
−2.72
0.0199


CMYA5
753
11960229
C
3.66
0.0275


CMYA5
754
6880680
C
5.09
0.0115


CMYA5
755
3828611
G
5.34
0.0158


SEMA5A
770
11134354
A
−3.63
0.0162


NKAIN2
794
1832252
G
2.47
0.0424


NKAIN2
796
1031881
C
−4.54
0.0044


NKAIN2
797
687667
A
−3.12
0.0487


UTRN
817
11155367
A
3.10
0.0467


SYNE1
819
718527
A
2.96
0.0146


ATXN1
841
909786
G
−2.89
0.0172


SLC17A4
844
9358890
G
8.10
0.0048


SLC17A1
845
1324082
A
−3.20
0.0299


BTN3A1
851
17610161
A
−4.15
0.0202


ELOVL5
867
9474507
A
3.73
0.0259


KLHL32
882
1737646
A
−4.54
0.0199


CUX1
885
2960266
A
2.63
0.0354


CUX1
886
2694158
T
3.06
0.0170


CADPS2
892
2428769
G
−2.82
0.0281


EXOC4
910
6954842
A
2.81
0.0384


DGKI
916
980796
A
−2.74
0.0389


CNTNAP2
928
6963627
T
2.45
0.0457


CNTNAP2
931
11972784
C
3.19
0.0238


CNTNAP2
934
10952682
G
3.24
0.0202


CNTNAP2
935
6953679
A
3.57
0.0107


CNTNAP2
936
700320
A
3.89
0.0040


CHN2
958
7781003
T
−2.79
0.0332


CRHR2
965
2190242
C
3.49
0.0166


BMPER
979
7806522
C
−3.72
0.0046


BMPER
981
12672492
A
−2.99
0.0345


CDC2L5
989
9639817
T
2.54
0.0432


CACNA2D1
1037
12531682
T
−3.63
0.0071


CACNA2D1
1039
2237524
G
−3.87
0.0058


CACNA2D1
1040
7788848
A
−3.38
0.0128


PCLO
1054
4129230
T
3.91
0.0028


PCLO
1055
10240976
T
3.07
0.0119


SEMA3E
1057
17287452
T
−4.42
0.0227


SEMA3E
1061
1972459
C
−2.71
0.0381


SEMA3A
1063
6965990
A
3.20
0.0092


SEMA3A
1064
11976072
T
3.05
0.0127


SEMA3A
1066
7806871
G
−3.06
0.0131


SEMA3A
1067
17298417
C
−2.88
0.0190


SEMA3A
1069
3801629
G
2.81
0.0237


SEMA3A
1070
727651
G
2.57
0.0378


ADAM22
1076
1688886
G
4.01
0.0012


ADAM22
1077
2282948
C
3.51
0.0055


ADAM22
1078
2282949
C
3.40
0.0066


ADAM22
1083
4140919
G
3.35
0.0471


NXPH1
1086
6962955
A
−2.97
0.0163


DYNC1I1
1093
6968143
G
4.08
0.0412


GRHL2
1096
13275653
C
−2.71
0.0346


GRHL2
1097
4734037
C
−3.86
0.0120


NCALD
1098
1131862
G
−3.80
0.0101


NCALD
1101
2226401
C
−3.66
0.0125


ZFPM2
1104
1481026
T
3.17
0.0283


FER1L6
1126
4355755
T
−2.85
0.0397


FER1L6
1127
7838453
A
−3.59
0.0024


FER1L6
1133
7819868
G
3.30
0.0069


COL22A1
1150
4475485
T
−4.12
0.0408


CSMD1
1179
4487803
G
3.28
0.0112


CSMD1
1180
17065933
A
−2.94
0.0425


CSMD1
1182
7829968
T
3.21
0.0237


CSMD1
1185
7014880
A
−2.75
0.0204


SFRP1
1188
4736959
C
2.58
0.0407


SFRP1
1189
11781990
A
2.82
0.0353


MCPH1
1197
1530408
C
3.54
0.0247


MCPH1
1209
2515435
G
2.86
0.0247


KCNB2
1227
13251896
G
−2.61
0.0327


KCNB2
1230
2196904
C
−2.70
0.0378


KCNB2
1232
13277104
G
−2.53
0.0397


MMP16
1236
6994019
T
−3.07
0.0256


MMP16
1238
3844198
A
−2.99
0.0331


MMP16
1241
4548227
A
−3.15
0.0177


GABBR2
1245
1930139
G
−3.17
0.0258


ABL1
1273
10901294
T
−4.94
0.0394


OLFM1
1278
665748
A
6.28
0.0044


OLFM1
1279
542172
A
6.02
0.0064


KIAA1797
1285
12338810
T
−4.00
0.0135


KIAA1797
1286
12336110
A
−3.94
0.0163


KIAA1797
1288
16938162
C
3.99
0.0016


KIAA1797
1289
10511687
G
3.87
0.0020


KIAA1797
1294
10511693
G
3.60
0.0094


KIAA1797
1298
7030990
G
3.66
0.0105


KIAA1797
1299
4977881
A
3.38
0.0125


KIAA1797
1300
4468020
T
3.24
0.0162


TEK
1308
2273719
T
−3.63
0.0418


PIP5K1B
1317
4745375
T
3.21
0.0184


PCSK5
1329
914367
T
−3.25
0.0118


NTRK2
1335
1187321
A
4.47
0.0069


NTRK2
1336
1187328
G
3.46
0.0409


ATE1
1363
7086628
C
−2.76
0.0196


ATE1
1364
1219505
T
−3.04
0.0093


MYO3A
1380
3781117
C
−3.63
0.0401


KCNMA1
1401
7897566
C
4.28
0.0006


ELMOD1
1419
683266
A
2.66
0.0404


MICAL2
1422
10765929
T
−2.82
0.0286


ARNTL
1430
7107711
C
−3.27
0.0325


SPON1
1440
10832170
T
2.59
0.0336


SPON1
1441
1406356
A
2.70
0.0285


SPON1
1442
7116296
T
−2.45
0.0472


INSC
1445
1792571
A
3.42
0.0146


C11ORF49
1453
12796744
T
−2.44
0.0483


DLG2
1466
6592202
C
−3.34
0.0072


DLG2
1467
4451754
A
−3.43
0.0068


DLG2
1469
11234194
C
−2.80
0.0278


DLG2
1471
11234222
A
−4.38
0.0004


DLG2
1474
6592211
A
−3.49
0.0044


DLG2
1475
7101454
C
−3.35
0.0067


KCNC2
1503
10735985
G
2.70
0.0349


KCNC2
1504
2471664
C
3.44
0.0209


NAV3
1510
10859620
G
−2.87
0.0220


NAV3
1513
1012088
G
3.39
0.0127


NAV3
1515
7295890
C
3.30
0.0152


ITGBL1
1532
4772403
T
−2.73
0.0378


ITGBL1
1535
1436261
C
−3.57
0.0159


FGF14
1538
7334753
C
2.84
0.0230


FGF14
1539
9518534
T
2.71
0.0305


FGF14
1540
10508075
A
2.49
0.0455


N4BP2L2
1543
206337
A
3.64
0.0169


N4BP2L2
1544
1081796
A
3.26
0.0422


N4BP2L2
1545
169600
A
2.86
0.0471


TRPC4
1562
3812837
C
3.67
0.0069


TRPC4
1563
1538146
T
3.40
0.0102


TRPC4
1564
9594238
C
−3.51
0.0315


FNDC3A
1567
2181539
G
3.11
0.0179


FNDC3A
1568
1983805
G
2.86
0.0285


SLAIN1
1573
1343911
A
−3.64
0.0227


SLAIN1
1575
9318496
T
3.29
0.0475


SLAIN1
1576
1146920
C
4.21
0.0023


SLAIN1
1577
8000788
T
4.37
0.0206


SLAIN1
1578
10507874
G
4.22
0.0235


GPC5
1585
9556229
G
5.01
0.0107


GPC6
1588
9516222
G
3.28
0.0370


GPC6
1595
9561551
C
−3.18
0.0257


NPAS3
1602
6571604
C
−5.66
0.0006


NPAS3
1603
6571605
A
−4.86
0.0024


SAMD4A
1617
8006657
A
2.82
0.0254


RGS6
1624
36318
G
2.73
0.0291


RGS6
1625
11158926
T
2.49
0.0392


CCDC88C
1642
4904770
T
−3.07
0.0493


BCL11B
1650
2614463
T
2.44
0.0429


RYR3
1654
2572175
A
−2.54
0.0380


RYR3
1658
11638307
A
−2.97
0.0499


C15ORF41
1663
8024344
C
−4.39
0.0190


TBC1D2B
1682
2241885
C
2.87
0.0222


TBC1D2B
1684
11634607
T
3.53
0.0061


TBC1D2B
1685
2867985
A
2.67
0.0456


ARNT2
1688
4628923
C
−3.39
0.0133


ARNT2
1689
11072931
T
−3.48
0.0356


ARNT2
1691
4778615
T
−3.63
0.0271


KIFC3
1697
8058401
G
−2.74
0.0441


KIFC3
1698
1559404
T
−4.24
0.0213


CDH13
1719
11150496
T
2.79
0.0246


CDH13
1722
2059230
T
2.55
0.0461


USP10
1732
8060725
A
3.56
0.0055


CA10
1749
11652641
G
−3.48
0.0220


MSI2
1751
8066677
G
−3.11
0.0158


SDK2
1754
1846334
A
−3.32
0.0086


OSBPL1A
1758
275857
C
7.89
0.0075


CDH7
1781
8092259
G
2.55
0.0466


PTPRM
1798
8089695
C
5.08
0.0245


KIAA0802
1803
12386117
A
−4.72
0.0055


MACROD2
1809
6079395
G
2.65
0.0309


PTPRT
1836
6065487
A
−2.54
0.0436


KCNB1
1844
6095546
A
−2.82
0.0441


CDH4
1847
4812313
G
−2.65
0.0485


PLCB4
1859
6077505
C
−2.74
0.0322


SLC37A1
1871
401396
C
−2.39
0.0418


SLC37A1
1872
381899
A
−2.75
0.0456


ARFGAP3
1876
6002963
G
−3.00
0.0178


PACSIN2
1882
4140554
C
−3.67
0.0027


PACSIN2
1883
7291153
C
−3.47
0.0048


PACSIN2
1887
737782
G
3.23
0.0081


PACSIN2
1888
2284097
C
−3.35
0.0061


PACSIN2
1889
738379
A
−3.24
0.0080


TTLL1
1891
135001
C
2.68
0.0263


TTLL1
1892
135002
C
2.63
0.0298


EFCAB6
1893
137160
G
2.61
0.0333
















TABLE 2







Alleles Influencing PANSS Scales














SEQ ID
NCBI

PANSS




Gene Name
NO:
RS #
Allele
Scale
Beta
P
















NGF
6
6327
A
General
−1.31
0.03698


NGF
7
7513144
C
Positive
1.13
0.02823


CGN
16
1547832
A
General
−2.33
0.02189


RP1-21O18.1
17
4661563
A
Negative
−0.90
0.04530


RP1-21O18.1
22
2235787
G
General
−1.39
0.03026


OLFML2B
25
4657131
A
Negative
1.08
0.02441


OLFML2B
26
2499836
T
Negative
1.04
0.03150


SEC16B
30
1934650
C
Positive
1.26
0.03996


RALGPS2
31
4652319
T
General
−1.76
0.01175


RALGPS2
32
12076230
G
General
−1.66
0.01214


USH2A
42
7548730
C
Positive
1.08
0.01006


USH2A
43
6665313
A
Positive
1.37
0.01278


USH2A
44
12403674
T
Positive
1.36
0.01382


USH2A
45
301759
T
Negative
0.93
0.02905


USH2A
46
301760
C
Negative
0.92
0.03137


USH2A
49
12030122
C
Negative
1.59
0.03936


ESRRG
50
6658528
T
General
−1.49
0.02399


ESRRG
56
2820879
A
General
−1.68
0.04989


ESRRG
56
2820879
A
Negative
−1.32
0.02803


RYR2
63
10802596
T
General
1.69
0.01523


RYR2
64
16835155
G
Negative
−1.50
0.02501


RYR2
65
3924864
C
General
2.32
0.03225


RYR2
66
2779400
A
General
−1.76
0.00703


CHRM3
69
16838637
G
General
1.27
0.03790


FMN2
76
12145060
A
Negative
0.92
0.04972


FMN2
76
12145060
A
General
1.57
0.01831


FMN2
77
12021945
C
General
1.41
0.03332


FMN2
79
11801848
C
General
1.48
0.03579


FMN2
83
1542400
G
General
−1.27
0.03929


FMN2
83
1542400
G
Positive
−0.79
0.03629


FMN2
85
11799544
T
Positive
1.43
0.04573


FMN2
86
10926257
T
General
2.29
0.04767


PLD5
88
924775
A
General
−1.84
0.02179


AGBL4-
91
319965
A
Negative
1.17
0.01131


C1ORF165








AGBL4-
97
3121518
A
General
−1.34
0.03132


C1ORF165








SCP2
98
3766762
C
General
−3.52
0.02101


ELTD1
100
17102632
T
Positive
1.23
0.02211


PRKACB
104
2134646
T
Positive
0.92
0.01931


HPCAL1
105
16856020
T
General
1.87
0.04416


HPCAL1
105
16856020
T
Negative
2.04
0.00178


KCNF1
106
4669647
T
Negative
1.08
0.04260


NTSR2
108
4669767
C
General
−1.38
0.03301


NAP5
109
4283469
A
Positive
−2.24
0.01708


RAB3GAP1
112
16831315
C
General
2.96
0.00574


RAB3GAP1
113
935614
G
General
2.00
0.04759


ZRANB3
114
16831601
T
General
2.57
0.01784


ZRANB3
115
16831751
G
General
2.89
0.00863


LRP1B
122
9283437
C
Positive
0.97
0.02021


LRP1B
125
12616665
G
Positive
−1.06
0.02819


LRP1B
127
12990449
C
Positive
−1.00
0.03679


LRP1B
128
352994
T
Positive
−0.98
0.03320


KYNU
129
2043944
T
Negative
1.52
0.00074


KYNU
130
10176234
A
Negative
1.48
0.00110


KYNU
131
351673
T
Negative
1.27
0.00346


ARHGAP15
140
10928200
T
Positive
0.98
0.01803


ARHGAP15
141
13031917
C
Negative
0.93
0.04590


ARHGAP15
141
13031917
C
Positive
0.94
0.02134


KIF5C
142
7355478
T
Positive
1.36
0.04467


KIF5C
143
4667369
C
Positive
−0.82
0.04565


FMNL2
145
1370504
C
Positive
0.91
0.04383


FMNL2
146
6434113
C
Positive
1.03
0.02260


FMNL2
148
3817620
G
Negative
−1.72
0.02497


KCNJ3
149
2961962
C
General
−1.77
0.00502


KCNJ3
150
2961957
C
General
−1.55
0.01804


KCNJ3
151
2937600
G
Positive
−0.91
0.03136


PKP4
152
6437190
G
Negative
1.43
0.01279


PKP4
153
2108217
C
Negative
1.39
0.01531


PKP4
154
2051946
T
Negative
1.00
0.02982


PKP4
155
1476672
T
Negative
1.16
0.04007


PKP4
157
2528635
G
Negative
1.02
0.02743


PKP4
158
2528582
G
General
−1.56
0.01977


PKP4
158
2528582
G
Negative
−1.12
0.01771


PKP4
159
2711072
C
Negative
1.03
0.03103


PLA2R1
161
3828324
C
Negative
−0.92
0.03300


PLA2R1
162
2667012
C
Negative
1.23
0.00572


KCNH7
164
12613181
C
Negative
−1.42
0.04160


SCN3A
165
11677254
C
General
−1.86
0.00493


SCN3A
165
11677254
C
Negative
−1.57
0.00074


SCN1A
166
6731591
C
Negative
−1.30
0.02573


SCN1A
167
7607543
C
Negative
−1.13
0.04935


SCN9A
169
7589835
A
Negative
1.40
0.04401


SCN9A
169
7589835
A
General
2.73
0.00528


SCN9A
170
6725008
C
General
2.05
0.02469


SCN9A
171
6746030
A
General
2.03
0.02833


SCN9A
172
2226711
C
General
1.98
0.03274


PDE1A
187
16823124
A
General
−1.77
0.00963


PDE1A
188
10497597
T
General
−1.63
0.01735


PDE1A
190
9332425
T
General
−1.66
0.01271


ALS2
191
3731702
C
Negative
−1.13
0.03035


PARD3B
196
1540369
G
Positive
0.91
0.04019


PARD3B
199
10490293
T
Positive
0.86
0.04547


PARD3B
202
1079943
G
General
−1.29
0.04578


NRP2
203
955395
T
General
−1.62
0.01216


NRP2
203
955395
T
Negative
−1.16
0.01021


NRP2
205
6435306
A
General
−1.38
0.03253


NRP2
205
6435306
A
Negative
−0.97
0.02904


PIP5K3
207
10497899
T
General
−4.21
0.01635


PIP5K3
207
10497899
T
Positive
−2.73
0.01236


ERBB4
209
12998535
T
Negative
−1.01
0.04673


CUL3
211
11891006
G
Negative
−1.31
0.03780


IRS1
212
2396427
G
Positive
1.43
0.03569


COL4A4
213
1317770
C
Positive
−0.95
0.01597


COL4A4
214
4566357
A
Positive
−0.79
0.04094


SAG
220
2304773
A
Negative
2.44
0.00076


SAG
221
894100
A
Positive
1.00
0.01983


KLHL29
222
747345
A
Positive
−1.03
0.01222


KLHL29
223
737565
A
Positive
−0.98
0.01504


KLHL29
224
747344
G
Positive
−0.97
0.01602


KLHL29
226
7570872
G
Positive
−1.00
0.01732


KCNK3
228
7584568
G
General
−1.35
0.03767


DPYSL5
231
540490
T
General
1.33
0.03877


BRE
234
17006590
C
Negative
−1.18
0.02453


CRIM1
237
6757374
T
General
2.27
0.04854


CRIM1
238
3770939
T
Negative
−1.09
0.02472


CRIM1
239
11885390
A
Negative
−0.97
0.04757


CRIM1
241
3732073
G
Negative
−1.09
0.01727


SLC8A1
246
417614
A
General
1.56
0.02508


SLC8A1
247
2072531
T
Positive
−0.87
0.02680


SLC8A1
248
417591
G
General
1.54
0.04341


SLC8A1
249
11885401
C
General
2.19
0.02219


SLC8A1
250
17026033
G
General
1.85
0.02261


SLC8A1
251
17026039
G
General
1.76
0.03210


HAAO
252
6738169
G
Negative
−1.06
0.02751


C2ORF34
257
786616
C
Negative
−1.36
0.01079


C2ORF34
259
1067343
A
Negative
−1.33
0.01141


C2ORF34
261
1067378
A
General
−1.49
0.04429


C2ORF34
261
1067378
A
Positive
−0.96
0.03708


C2ORF34
264
1067402
T
Negative
−1.31
0.01452


C2ORF34
265
698792
A
Negative
−1.28
0.01651


C2ORF34
275
3738980
C
General
−2.20
0.01320


C2ORF34
275
3738980
C
Negative
−2.13
0.00060


PRKCE
276
666334
T
Negative
1.13
0.02631


PRKCE
277
6748375
C
Negative
0.90
0.04040


PRKCE
277
6748375
C
General
1.51
0.01573


PSME4
282
805391
T
General
−1.78
0.00430


PSME4
282
805391
T
Negative
−1.41
0.00121


PSME4
283
805330
A
Negative
−1.19
0.00681


PSME4
284
805360
T
Negative
−1.16
0.01190


PSME4
286
10183655
T
Negative
−1.15
0.01001


ACYP2
287
918357
G
Negative
1.17
0.00787


ACYP2
288
12615749
G
Negative
−1.55
0.02400


ACYP2
289
12615793
A
Negative
−1.46
0.03388


ACYP2
290
17045754
C
General
−2.54
0.00730


CCDC85A
291
4672096
G
Positive
−1.56
0.02603


CCDC85A
292
1159916
G
Negative
1.32
0.00552


CCDC85A
293
214047
C
General
−2.12
0.02041


AAK1
299
12622388
G
General
−1.40
0.04950


CTNNA2
300
7597912
T
General
−1.95
0.00726


CTNNA2
301
2566539
T
General
−1.87
0.00808


CTNNA2
303
2566542
C
General
−1.64
0.03645


CTNNA2
304
7571658
C
Positive
−1.05
0.00824


CTNNA2
306
318362
C
Positive
0.85
0.03781


CTNNA2
307
895388
T
Positive
−1.69
0.02012


CTNNA2
308
7589069
C
Negative
1.78
0.00945


CTNNA2
309
1444539
C
Negative
1.36
0.04336


CTNNA2
310
1434064
G
Negative
−0.99
0.03073


CTNNA2
311
216616
G
Negative
−1.03
0.03792


CTNNA2
312
6547316
T
General
1.38
0.03631


C2ORF46
313
7577544
G
Positive
−1.34
0.04931


DDEF2
316
10204214
T
Positive
1.46
0.01377


DDEF2
316
10204214
T
General
1.91
0.04488


PLCXD2
320
1513331
C
General
2.46
0.00661


PLCXD2
322
6796087
T
Positive
−1.10
0.00678


PLCXD2
323
6784753
C
Positive
−1.06
0.00841


PLCXD2
324
12490166
A
Positive
0.87
0.03462


KALRN
327
16835912
C
Positive
1.05
0.00881


KALRN
327
16835912
C
General
1.60
0.01344


CNTN6
328
3772339
T
Positive
−1.06
0.01236


CNTN6
329
4286413
T
Positive
−0.87
0.03300


CPNE4
330
10934970
C
General
3.49
0.03174


CPNE4
331
13319291
G
Positive
0.85
0.03827


CPNE4
333
9289393
T
Negative
0.92
0.04938


CPNE4
334
1875619
C
Positive
2.47
0.02017


CPNE4
335
1393561
T
Positive
2.45
0.02112


CPNE4
336
9289395
G
Negative
1.33
0.00639


CPNE4
337
17297521
C
General
2.25
0.01856


CPNE4
338
6806898
T
General
2.12
0.02401


CNTN6
339
265799
G
Positive
−0.84
0.02808


RAB6B
340
6765093
G
Positive
0.79
0.04449


RAB6B
340
6765093
G
Negative
0.91
0.04151


RAB6B
340
6765093
G
General
1.37
0.03067


CNTN6
341
265767
A
Positive
−0.95
0.01664


CNTN6
342
2055738
C
Positive
−0.96
0.01615


CNTN6
343
3772290
T
Positive
−0.83
0.03513


EPHB1
345
4955520
A
Positive
1.08
0.00739


EPHB1
347
4955522
A
Positive
1.08
0.00739


EPHB1
348
185257
T
Positive
0.99
0.01383


EPHB1
349
9825380
T
Positive
1.09
0.00745


EPHB1
350
4955524
A
Positive
1.04
0.01026


EPHB1
351
936323
T
Positive
0.97
0.01685


CLSTN2
356
9836487
G
General
1.50
0.02082


CLSTN2
358
4683499
G
Negative
0.97
0.03915


CLSTN2
358
4683499
G
General
1.43
0.03230


CLSTN2
359
6439927
C
Negative
1.34
0.00714


SPSB4
363
7651293
T
Positive
−2.08
0.02000


SLC6A6
365
1156567
C
Negative
−1.47
0.03132


SERPINI1
369
1492023
A
Positive
−1.22
0.03118


SERPINI1
370
11928048
T
Positive
−1.19
0.03397


SLC7A14
371
1861938
T
General
−1.51
0.02914


SLC7A14
372
6788596
G
General
−1.46
0.03211


SLC7A14
372
6788596
G
Positive
−0.89
0.03413


PLD1
377
7633686
G
General
−1.90
0.04844


PLD1
378
6767600
T
Positive
−1.32
0.02048


PLD1
379
2178532
A
Positive
−1.31
0.02693


NLGN1
380
4894645
T
Positive
1.58
0.00617


NLGN1
381
12636180
T
Positive
0.95
0.04199


HTR3D
385
939334
G
Negative
1.14
0.01755


HTR3D
386
6779545
A
Negative
1.29
0.00582


HTR3D
386
6779545
A
General
1.34
0.04623


IL1RAP
394
6791374
C
Negative
−2.58
0.00275


CENTB2
396
2050810
A
Negative
1.13
0.04537


CENTB2
397
9859822
G
Negative
−1.11
0.03605


UBXD7
398
3973
T
General
−1.38
0.04893


RARB
400
17525900
C
Negative
−1.88
0.01234


CNTN4
405
1420020
G
General
2.22
0.04942


CLASP2
410
9853831
T
General
−1.28
0.04451


CLASP2
411
7641020
G
General
−1.44
0.02355


STAC
413
17186340
T
General
2.69
0.01598


ULK4
415
1495698
C
General
1.87
0.00579


ULK4
416
1691964
T
General
2.35
0.00019


ULK4
417
1691966
G
Negative
1.34
0.00244


ULK4
418
1691998
G
Negative
1.22
0.00598


ULK4
419
13069172
G
Negative
1.18
0.00788


ULK4
419
13069172
G
General
2.34
0.00019


SEMA3F
424
2518796
G
Positive
0.84
0.04723


SEMA3F
425
12632110
A
Negative
−0.95
0.04788


CACNA2D2
426
743757
C
Positive
−1.10
0.04985


CACNA2D3
427
11130396
T
Positive
−1.07
0.01458


ERC2
433
1993539
T
Negative
1.17
0.04242


ERC2
435
7647972
C
Negative
−0.98
0.04457


ERC2
438
7619653
C
Negative
−1.01
0.03263


ERC2
440
17825409
C
Negative
−1.29
0.00721


ERC2
442
4974200
G
Negative
−1.26
0.00942


ERC2
443
4974206
G
Negative
−1.10
0.02160


ERC2
444
13064525
C
Negative
−1.09
0.02620


ERC2
445
1546060
C
Negative
−1.51
0.00117


ERC2
446
6805882
C
Negative
−1.44
0.00174


ERC2
447
885211
A
Negative
−1.25
0.00744


ERC2
450
9873381
A
Negative
−1.16
0.01153


ERC2
453
7627759
C
Negative
−1.06
0.02017


FHIT
454
639244
G
Negative
1.46
0.00222


FHIT
454
639244
G
General
1.86
0.00613


FHIT
455
2253211
C
Negative
1.24
0.00506


FHIT
455
2253211
C
General
1.31
0.03719


FHIT
456
2121865
T
General
1.45
0.02600


FHIT
457
13320646
A
Negative
0.93
0.04266


FHIT
458
7631246
T
Negative
0.91
0.04386


PTPRG
459
624755
G
Positive
0.86
0.03164


CADPS
467
1355551
T
Negative
1.60
0.00679


CADPS
469
9311842
T
Negative
1.24
0.01790


CADPS
471
13313979
A
General
−1.53
0.02767


CADPS
471
13313979
A
Negative
−1.13
0.02112


CADPS
473
186236
C
Negative
−1.19
0.01263


CADPS
474
17280557
A
General
−1.61
0.03648


CADPS
474
17280557
A
Negative
−1.48
0.00616


CADPS
475
17280571
T
Negative
−1.46
0.00361


CADPS
476
17357618
C
General
−1.60
0.02389


CADPS
476
17357618
C
Negative
−1.30
0.00899


CADPS
477
11925708
A
General
−1.65
0.00918


PRICKLE2
479
161661
A
Negative
1.10
0.01731


MAGI1
482
2371948
A
General
4.96
0.01513


MAGI1
483
9845819
C
General
−1.65
0.01521


MAGI1
484
7612636
C
Positive
0.80
0.04761


FAM19A1
485
11707519
G
Negative
−1.62
0.01054


FOXP1
487
2196356
C
Positive
0.94
0.02442


GBE1
490
7622741
G
Negative
1.06
0.02757


GBE1
490
7622741
G
General
1.75
0.01095


GBE1
491
6769230
A
Negative
1.00
0.03881


GBE1
491
6769230
A
General
1.75
0.01152


GBE1
492
2307058
T
General
1.63
0.01934


GBE1
494
7613144
T
General
1.59
0.02238


GBE1
495
17019088
T
Positive
−0.99
0.04502


GBE1
498
2680245
A
General
−1.43
0.02444


GBE1
498
2680245
A
Negative
−0.98
0.02995


GBE1
499
3860595
C
Negative
0.96
0.03451


HTR1F
500
1027689
T
Positive
1.46
0.02814


HTR1F
500
1027689
T
General
2.38
0.02649


DKK2
505
379333
T
Positive
−1.49
0.03572


COL25A1
508
794149
G
Negative
0.97
0.03330


COL25A1
509
3096483
C
Negative
0.94
0.04193


COL25A1
510
3096489
C
Negative
0.91
0.04566


ANK2
512
13134375
C
Negative
−1.38
0.00232


ANK2
513
13107082
G
Negative
1.37
0.00252


ANK2
514
413019
C
Negative
1.34
0.00306


ANK2
517
29306
G
Negative
1.14
0.02465


ANK2
518
29311
A
Negative
1.37
0.00716


ANK2
518
29311
A
General
1.80
0.01303


NDST3
521
2389501
A
Positive
−1.24
0.04798


MAML3
525
6819304
A
General
−1.91
0.04975


IL15
527
17007695
C
Positive
1.51
0.03432


INPP4B
528
2667101
G
Negative
0.96
0.03672


INPP4B
529
2667108
C
General
4.31
0.03599


INPP4B
531
1353603
A
Negative
3.06
0.00875


INPP4B
532
336329
G
Negative
2.97
0.03997


INPP4B
532
336329
G
General
4.31
0.03599


INPP4B
533
17015544
T
Positive
1.63
0.00671


INPP4B
534
2276942
A
Positive
2.11
0.00222


INPP4B
535
3775655
C
Positive
1.84
0.00689


INPP4B
536
2627828
G
Positive
1.91
0.03133


POU4F2
538
1979903
C
Negative
−2.17
0.01897


FSTL5
543
6825091
A
General
1.85
0.01004


FSTL5
544
7442468
C
General
1.79
0.01173


FSTL5
545
1431490
G
General
2.68
0.01648


FSTL5
546
12499128
A
General
2.60
0.01918


FSTL5
547
17459658
C
General
2.01
0.03261


LDB2
552
157631
G
General
3.03
0.01049


LDB2
553
284210
T
General
2.50
0.04007


LDB2
556
13110882
G
Negative
−1.30
0.00288


TLL1
557
11942650
G
Positive
−1.88
0.04937


PALLD
559
17054309
A
Negative
−1.21
0.04563


PALLD
564
3109206
T
Negative
−1.20
0.00755


PALLD
565
11930576
C
Negative
−1.15
0.01329


PALLD
566
4425335
G
Negative
−1.45
0.00572


PALLD
567
4280700
T
Negative
−1.46
0.02035


PALLD
568
12511925
T
Negative
−1.31
0.04313


ODZ3
570
2726792
G
Positive
1.01
0.01596


ODZ3
571
2675534
T
Negative
1.77
0.00084


ODZ3
572
2675532
C
Positive
0.90
0.03089


ODZ3
572
2675532
C
Negative
1.38
0.00338


ODZ3
572
2675532
C
General
1.51
0.02450


ENPP6
574
6830766
G
General
−1.36
0.03770


ENPP6
575
4431268
A
General
−1.55
0.02259


ENPP6
576
4241786
C
General
−1.53
0.02423


ENPP6
577
4340829
A
General
−1.46
0.02730


ENPP6
578
6815145
A
General
−1.47
0.03043


ENPP6
579
17584049
C
General
−1.85
0.00475


ENPP6
579
17584049
C
Positive
−1.02
0.01215


KIAA1239
589
4585313
C
General
3.06
0.01647


KIAA1239
590
17575883
A
Positive
−1.10
0.04116


KIAA1239
592
2973226
C
Positive
−0.95
0.01429


KIAA1239
593
1382979
A
Positive
−1.04
0.02140


UBE2K
595
2054718
T
Positive
1.27
0.01985


UBE2K
596
192779
A
Positive
1.28
0.01435


LIMCH1
598
4343753
T
General
2.02
0.00656


NPFFR2
611
7654531
T
Negative
1.04
0.03353


NPFFR2
612
6824703
C
Negative
1.04
0.03375


NPFFR2
614
17775309
G
General
−1.64
0.01530


SCD5
620
7679857
A
Positive
−1.24
0.02071


SCD5
621
7684732
C
General
−1.83
0.02561


SCD5
622
17006038
C
Positive
−1.24
0.02202


SCD5
622
17006038
C
Negative
−1.20
0.04882


SCD5
623
6848340
T
General
−2.27
0.03066


FAM13A1
626
4544678
C
General
1.49
0.01797


FAM13A1
627
7691186
G
General
1.48
0.01929


PDLIM5
632
6812098
C
General
1.68
0.04393


SLC2A9
637
13111638
T
Negative
−1.40
0.01145


SLC2A9
641
12509955
T
Negative
−1.34
0.01153


SLC2A9
643
7671266
T
Negative
−1.45
0.00682


FBXL17
646
11242664
G
Negative
1.33
0.02514


FBXL17
646
11242664
G
General
1.86
0.02767


PJA2
653
11957188
T
Positive
−2.79
0.00495


KCNN2
654
1457762
A
General
1.34
0.03426


HSD17B4
662
246968
A
General
−1.60
0.00943


SNX2
669
12109789
G
Positive
0.79
0.04779


SNX2
670
10519715
A
Negative
0.97
0.04493


SNX2
670
10519715
A
General
1.42
0.03964


SNX2
671
2407403
G
Negative
−1.14
0.01761


SNX24
672
6888023
T
General
1.42
0.03843


SNX24
673
246286
T
Negative
−0.97
0.03999


SNX24
674
246266
C
Negative
−0.96
0.04460


SNX24
674
246266
C
Positive
−0.86
0.04092


SNX24
675
6866400
A
Negative
0.96
0.04515


VDAC1
677
4958172
A
General
−1.98
0.03716


TRPC7
680
3777150
A
Negative
1.13
0.01239


TRPC7
682
963590
C
Positive
−0.91
0.03266


DNAH5
686
10513155
A
General
1.39
0.03933


DNAH5
688
4701997
T
General
2.38
0.00027


DNAH5
691
13154455
G
General
2.22
0.00079


GRIA1
694
7735696
C
Negative
0.98
0.02728


GRIA1
695
17518831
C
Negative
0.90
0.04258


GRIA1
696
778822
C
Positive
−1.18
0.00987


GRIA1
701
7708391
A
General
−1.47
0.03123


ODZ2
704
2337017
C
General
−3.31
0.00022


ODZ2
704
2337017
C
Negative
−1.45
0.02177


MYO10
705
428263
A
Positive
0.92
0.02306


MYO10
706
388887
T
Positive
0.87
0.03024


ODZ2
707
7714651
A
General
−2.07
0.03300


ODZ2
707
7714651
A
Positive
−1.38
0.02204


ODZ2
708
1421989
G
General
−2.67
0.00145


ODZ2
708
1421989
G
Positive
−1.53
0.00320


ODZ2
711
6868169
G
Positive
1.19
0.00429


ODZ2
711
6868169
G
General
1.55
0.02104


ODZ2
712
11748886
G
Positive
1.72
0.04326


MYO10
713
11750538
G
Positive
−0.88
0.03391


MYO10
714
11133860
G
Positive
−1.16
0.01532


PLEKHG4B
716
9312845
T
Negative
1.69
0.00876


PLEKHG4B
717
9312850
G
Negative
1.56
0.01509


PLEKHG4B
718
6888246
T
Negative
1.55
0.01701


PLEKHG4B
719
3853521
A
Negative
1.57
0.01763


PLEKHG4B
720
6885136
C
General
1.37
0.02941


CDH10
722
3822429
T
General
−1.48
0.02017


CDH10
722
3822429
T
Negative
−1.07
0.01629


CDH10
722
3822429
T
Positive
−1.02
0.00950


SLC45A2
723
35388
T
Negative
−1.00
0.02024


SLC45A2
724
2278008
C
Negative
−0.98
0.04719


C1QTNF3
725
17583316
C
Negative
−1.27
0.00913


C1QTNF3
728
9292523
C
Negative
−1.11
0.01589


EGFLAM
730
4869580
T
Negative
1.66
0.01214


AHRR
734
4956936
C
Negative
1.01
0.03880


AHRR
735
2672734
C
Negative
−1.12
0.01572


EXOC3
736
2561667
T
Negative
−1.05
0.02605


ITGA1
739
1047481
G
General
−1.35
0.04787


ITGA2
740
3212576
G
Negative
1.17
0.04568


CMYA5
753
11960229
C
General
2.02
0.01984


CMYA5
754
6880680
C
General
2.80
0.00792


CMYA5
755
3828611
G
Negative
1.86
0.02235


CMYA5
755
3828611
G
General
2.70
0.01945


SEMA5A
768
985723
A
Negative
1.48
0.02151


SEMA5A
769
257094
C
Negative
1.30
0.04861


SEMA5A
770
11134354
A
General
−2.05
0.00944


SEMA5A
771
4702625
G
General
−1.88
0.01741


SEMA5A
772
268481
C
General
−2.13
0.02437


SEMA5A
773
268529
G
General
−1.34
0.04990


SLC22A16
775
9398237
T
Negative
−1.24
0.01156


TRDN
778
2873479
A
Negative
1.59
0.03459


TRDN
779
17737379
T
Negative
−1.54
0.01951


TRDN
780
1367674
T
Negative
1.33
0.03747


NKAIN2
793
6910988
T
Negative
−0.95
0.02895


NKAIN2
794
1832252
G
Negative
1.01
0.02390


NKAIN2
795
1871329
C
General
−2.30
0.00182


NKAIN2
796
1031881
C
General
−2.58
0.00200


NKAIN2
796
1031881
C
Positive
−1.11
0.03233


NKAIN2
797
687667
A
General
−2.04
0.01379


NKAIN2
798
497817
G
General
−1.77
0.02935


NKAIN2
799
609783
T
General
−1.76
0.03029


NKAIN2
800
781487
C
Positive
1.85
0.00482


PDE7B
810
6570049
T
Positive
−2.10
0.02725


UTRN
817
11155367
A
General
1.73
0.03241


SYNE1
818
2813484
G
Negative
−0.94
0.04334


SYNE1
819
718527
A
General
1.40
0.02741


PARK2
824
9365311
C
General
−1.45
0.02482


PARK2
826
7750426
G
Negative
−0.99
0.02186


PARK2
827
9295173
G
Negative
0.92
0.03672


PARK2
828
10945823
A
Negative
1.08
0.03564


PARK2
829
2846470
A
Negative
−1.00
0.03486


PDE10A
837
566759
G
Negative
−1.47
0.02131


ATXN1
839
235147
A
Negative
−1.11
0.01191


ATXN1
841
909786
G
General
−1.42
0.02549


SLC17A4
844
9358890
G
Positive
2.64
0.00453


SLC17A4
844
9358890
G
General
4.20
0.00520


SLC17A1
845
1324082
A
Negative
−1.16
0.03294


SLC17A3
848
1165158
T
Positive
−1.03
0.03652


SLC17A2
849
442601
C
General
−1.56
0.02006


BTN3A1
851
17610161
A
General
−2.16
0.02111


LRFN2
861
9369205
A
Negative
1.30
0.00591


LRFN2
863
403319
A
Negative
−0.93
0.04704


PPP2R5D
864
3823423
A
Positive
1.57
0.03282


KLC4
865
4714658
A
Positive
2.32
0.01682


ELOVL5
867
9474507
A
General
1.85
0.03489


RIMS1
869
530028
G
Positive
−1.11
0.00434


RIMS1
870
511211
C
Positive
−1.10
0.00527


RIMS1
875
2463749
C
Positive
−0.85
0.03747


RIMS1
877
1015945
G
Positive
−0.92
0.02887


KLHL32
882
1737646
A
General
−2.34
0.02228


CUX1
884
940482
T
Negative
−1.52
0.01147


CUX1
885
2960266
A
Positive
0.94
0.02025


CUX1
886
2694158
T
Positive
1.04
0.01248


CUX1
886
2694158
T
General
1.46
0.02952


CADPS2
887
2471212
G
Positive
1.20
0.01064


CADPS2
888
1476898
T
Positive
0.99
0.04874


CADPS2
889
2471194
A
Positive
0.99
0.04663


CADPS2
892
2428769
G
General
−1.41
0.03591


CADPS2
892
2428769
G
Negative
−0.95
0.04415


EXOC4
910
6954842
A
Negative
1.08
0.03039


DGKI
915
16874961
C
Positive
−1.14
0.00805


DGKI
916
980796
A
Positive
−1.07
0.01273


CREB3L2
917
273981
C
Positive
1.07
0.00707


CREB3L2
918
273988
A
Positive
1.06
0.00696


CREB3L2
919
273992
C
Positive
−0.95
0.02157


TBXAS1
923
41723
G
Negative
1.51
0.01523


ETV1
924
9639168
C
General
1.52
0.02832


CNTNAP2
926
1639481
G
Positive
0.86
0.02913


CNTNAP2
929
1639484
T
Positive
0.82
0.03752


CNTNAP2
931
11972784
C
General
1.61
0.02929


CNTNAP2
932
4726861
A
Positive
0.98
0.03148


CNTNAP2
933
2022226
C
Positive
1.00
0.01451


CNTNAP2
934
10952682
G
Positive
1.08
0.01747


CNTNAP2
934
10952682
G
General
1.64
0.02495


CNTNAP2
935
6953679
A
Positive
1.27
0.00514


CNTNAP2
935
6953679
A
General
1.76
0.01632


CNTNAP2
936
700320
A
Positive
1.25
0.00455


CNTNAP2
936
700320
A
General
1.77
0.01287


CNTNAP2
937
1404731
C
General
−2.25
0.04818


PTPRN2
943
10265417
T
Positive
−0.80
0.04787


STK31
944
12532929
T
General
1.71
0.03979


CHN2
958
7781003
T
General
−1.41
0.03974


CHN2
958
7781003
T
Positive
−0.88
0.03774


CHN2
959
3750103
C
General
2.93
0.02045


CHN2
960
10951234
C
Positive
−1.04
0.04125


ZNRF2
964
42603
G
Negative
2.11
0.04303


CRHR2
965
2190242
C
Positive
0.97
0.03961


CRHR2
965
2190242
C
Negative
1.14
0.03332


CRHR2
966
4723003
T
General
2.30
0.03182


FLJ22374
968
7781249
A
General
1.31
0.03675


FLJ22374
971
10258097
A
General
−1.43
0.02758


BMPER
976
6975236
T
Negative
1.09
0.02086


BMPER
979
7806522
C
General
−1.86
0.00672


BMPER
979
7806522
C
Negative
−1.02
0.03492


BMPER
979
7806522
C
Positive
−0.84
0.04938


VPS41
983
17768153
A
Negative
1.25
0.04993


CDC2L5
987
10272641
G
Negative
0.89
0.04734


CDC2L5
989
9639817
T
Negative
1.11
0.01672


CDC2L5
990
17171658
T
Negative
0.97
0.03259


SDK1
991
11766511
G
Positive
0.77
0.04561


ABCA13
1001
3923511
G
Positive
−0.92
0.04200


GRB10
1003
2244347
C
Negative
1.11
0.02401


GRB10
1004
6976501
G
General
−1.65
0.04393


WBSCR17
1006
757841
C
General
1.31
0.03691


WBSCR17
1008
2190223
C
General
1.32
0.03726


LIMK1
1011
2855726
A
Negative
1.01
0.03860


LIMK1
1012
444606
G
Negative
0.99
0.04151


LIMK1
1013
398608
T
Negative
1.01
0.04762


GTF2IRD1
1014
2267834
G
Positive
1.07
0.01631


MAGI2
1020
10238177
A
Positive
−0.94
0.03100


MAGI2
1026
6954793
C
Negative
1.65
0.01244


MAGI2
1027
10280554
T
Negative
1.59
0.01300


MAGI2
1028
7778707
G
Negative
1.55
0.02511


MAGI2
1031
4730829
C
Negative
1.31
0.01825


CACNA2D1
1033
258728
A
Negative
−1.26
0.01477


CACNA2D1
1034
2059037
C
Negative
−1.70
0.00734


CACNA2D1
1036
7781562
A
Positive
−1.07
0.01486


CACNA2D1
1037
12531682
T
General
−1.54
0.02929


CACNA2D1
1037
12531682
T
Negative
−1.06
0.03247


CACNA2D1
1038
978326
C
General
−1.58
0.02696


CACNA2D1
1038
978326
C
Negative
−1.11
0.02788


CACNA2D1
1039
2237524
G
General
−1.60
0.02896


CACNA2D1
1039
2237524
G
Positive
−1.16
0.01094


CACNA2D1
1039
2237524
G
Negative
−1.12
0.03117


CACNA2D1
1040
7788848
A
General
−1.44
0.04357


CACNA2D1
1040
7788848
A
Negative
−1.01
0.04418


CACNA2D1
1040
7788848
A
Positive
−0.93
0.03516


PCLO
1046
2888019
T
Positive
0.77
0.04641


PCLO
1049
12539066
T
Positive
−1.33
0.00307


PCLO
1052
17157177
T
General
−1.45
0.02225


PCLO
1053
16887406
G
General
−1.25
0.04624


PCLO
1054
4129230
T
Positive
0.90
0.03415


PCLO
1054
4129230
T
General
1.88
0.00620


PCLO
1055
10240976
T
Negative
1.24
0.00568


PCLO
1055
10240976
T
General
1.36
0.03362


SEMA3E
1056
2722963
G
General
1.34
0.04670


SEMA3E
1057
17287452
T
Negative
−1.62
0.02340


SEMA3E
1060
3801562
C
General
1.41
0.02882


SEMA3E
1061
1972459
C
General
−1.50
0.02815


SEMA3A
1062
2535786
A
Negative
−1.15
0.03083


SEMA3A
1063
6965990
A
Positive
0.86
0.03141


SEMA3A
1063
6965990
A
Negative
1.10
0.01479


SEMA3A
1064
11976072
T
Negative
1.08
0.01598


SEMA3A
1065
13228082
G
Negative
1.06
0.01895


SEMA3A
1066
7806871
G
Negative
−1.03
0.02271


SEMA3A
1066
7806871
G
Positive
−0.86
0.03166


SEMA3A
1067
17298417
C
Negative
−1.00
0.02690


SEMA3A
1067
17298417
C
Positive
−0.79
0.04662


SEMA3A
1068
10488268
T
Negative
0.96
0.03467


SEMA3A
1069
3801629
G
Negative
0.95
0.03703


ABCB4
1072
2097937
G
Negative
−1.18
0.04542


ABCB4
1073
31662
A
General
−2.27
0.02439


ABCB4
1074
31671
G
Positive
0.98
0.04998


ADAM22
1076
1688886
G
Positive
1.41
0.00059


ADAM22
1076
1688886
G
General
1.73
0.00790


ADAM22
1077
2282948
C
General
1.50
0.02362


ADAM22
1078
2282949
C
Positive
1.38
0.00067


ADAM22
1078
2282949
C
General
1.42
0.02975


ADAM22
1079
6951172
T
Positive
1.06
0.01095


ADAM22
1080
9632709
C
Positive
1.09
0.00887


ADAM22
1081
2299199
G
Positive
1.03
0.01243


ADAM22
1083
4140919
G
Positive
1.09
0.04647


ADAM22
1083
4140919
G
General
1.85
0.03572


ADAM22
1084
2299205
T
Positive
1.38
0.04625


NXPH1
1086
6962955
A
General
−1.65
0.01131


PON1
1090
2057681
G
General
−1.36
0.04956


PON1
1091
705378
T
General
1.38
0.03793


DYNC1I1
1093
6968143
G
General
2.57
0.01413


GRHL2
1096
13275653
C
General
−1.56
0.02002


GRHL2
1096
13275653
C
Negative
−1.02
0.03158


GRHL2
1097
4734037
C
General
−2.00
0.01321


NCALD
1098
1131862
G
General
−2.12
0.00599


NCALD
1098
1131862
G
Negative
−1.15
0.03461


NCALD
1099
16868201
A
General
−2.08
0.01430


NCALD
1099
16868201
A
Negative
−1.17
0.04984


NCALD
1101
2226401
C
General
−1.87
0.01488


ZFPM2
1102
16873003
C
General
2.06
0.00671


ZFPM2
1103
6992053
A
General
2.01
0.00736


ZFPM2
1104
1481026
T
General
1.95
0.00957


ZFPM2
1105
302957
C
General
1.29
0.04556


ZFPM2
1107
7003141
C
Positive
1.04
0.01769


ZFPM2
1108
1025856
C
Positive
0.83
0.03562


ZFPM2
1110
2958710
G
Positive
0.81
0.04240


CSMD3
1111
6981814
A
Positive
−1.16
0.01347


CSMD3
1112
10505174
A
Positive
−1.01
0.03301


CSMD3
1113
10216803
T
Positive
−0.99
0.03494


CSMD3
1114
16883753
T
Positive
−0.97
0.03940


CSMD3
1118
4354335
G
Negative
1.04
0.03539


SAMD12
1119
4629902
A
Positive
0.86
0.03641


SAMD12
1123
1607924
G
Negative
0.95
0.04672


FBXO32
1125
6990407
G
Positive
−1.07
0.04614


FER1L6
1127
7838453
A
General
−1.65
0.00776


FER1L6
1127
7838453
A
Positive
−1.09
0.00467


FER1L6
1127
7838453
A
Negative
−0.86
0.04907


FER1L6
1133
7819868
G
Positive
1.05
0.00814


FER1L6
1133
7819868
G
General
1.49
0.02014


FER1L6
1134
4521739
G
Positive
0.99
0.01293


FER1L6
1135
11784115
A
Positive
0.94
0.01813


FER1L6
1136
10103694
T
Negative
−1.18
0.02336


DLC1
1139
2203838
C
Negative
−1.51
0.01065


ADCY8
1142
7464362
G
General
1.35
0.03729


ADCY8
1143
11781997
A
General
1.58
0.01106


ADCY8
1144
7459573
G
General
1.43
0.02701


KCNQ3
1146
6471066
G
General
1.71
0.04615


COL22A1
1150
4475485
T
General
−2.77
0.00847


COL22A1
1151
7838450
C
Positive
−0.80
0.04576


COL22A1
1152
13279213
A
Negative
1.12
0.02925


SGCZ
1154
11990657
T
General
1.52
0.03744


SGCZ
1156
4427170
T
General
1.51
0.01977


SLC7A2
1159
2720574
C
General
−1.89
0.04017


ENTPD4
1173
17089263
G
Positive
1.47
0.04339


CSMD1
1179
4487803
G
General
1.72
0.01061


CSMD1
1182
7829968
T
General
1.67
0.02433


CSMD1
1185
7014880
A
General
−1.60
0.00997


UNC5D
1186
2589344
T
Negative
−1.56
0.00589


SFRP1
1188
4736959
C
Positive
1.07
0.00917


SFRP1
1190
11779707
C
Positive
0.99
0.01758


SFRP1
1191
7833518
T
Positive
0.82
0.04424


SFRP1
1192
968427
G
Negative
−0.88
0.04825


MCPH1
1197
1530408
C
General
2.01
0.01503


MCPH1
1202
2920660
A
General
1.83
0.03201


MCPH1
1203
2916741
G
General
1.74
0.04297


NKAIN3
1207
17245081
A
General
1.39
0.03183


MCPH1
1208
3020213
T
Positive
0.90
0.03313


MCPH1
1209
2515435
G
General
1.33
0.04676


DEPDC2
1216
7006061
T
Positive
1.30
0.03870


DEPDC2
1219
6990381
T
Negative
0.94
0.03520


KCNB2
1227
13251896
G
Negative
−1.10
0.01395


KCNB2
1227
13251896
G
Positive
−0.82
0.03948


KCNB2
1230
2196904
C
Negative
−1.11
0.01975


KCNB2
1231
1866740
A
Negative
−0.93
0.04845


KCNB2
1232
13277104
G
Negative
−1.02
0.02351


KCNB2
1232
13277104
G
Positive
−0.89
0.02549


MMP16
1236
6994019
T
General
−1.78
0.01335


MMP16
1236
6994019
T
Negative
−1.07
0.03595


MMP16
1237
1879203
C
Negative
−1.10
0.03726


MMP16
1238
3844198
A
General
−1.70
0.02028


MMP16
1241
4548227
A
Negative
−1.40
0.00384


GABBR2
1242
1435253
T
General
−1.91
0.01876


GABBR2
1243
10985765
C
General
−1.86
0.01922


GABBR2
1244
2778913
T
General
−2.14
0.03218


GABBR2
1245
1930139
G
Negative
−1.24
0.01820


STOM
1260
17086
G
Positive
−0.79
0.04711


FREQ
1269
12003792
A
Positive
0.88
0.04157


ABL1
1273
10901294
T
General
−3.10
0.01311


TSC1
1275
11243940
G
Positive
−1.03
0.02027


TSC1
1276
7035308
A
Positive
−0.90
0.04546


OLFM1
1278
665748
A
Positive
1.49
0.03800


OLFM1
1278
665748
A
General
3.50
0.00246


OLFM1
1279
542172
A
General
3.19
0.00573


INPP5E
1280
3812591
C
Negative
1.28
0.01173


KIAA1797
1285
12338810
T
General
−2.65
0.00175


KIAA1797
1285
12338810
T
Positive
−1.17
0.02646


KIAA1797
1286
12336110
A
General
−2.65
0.00204


KIAA1797
1286
12336110
A
Positive
−1.12
0.03654


KIAA1797
1289
10511687
G
Negative
1.52
0.00099


KIAA1797
1289
10511687
G
General
2.10
0.00138


KIAA1797
1291
2383162
G
General
−1.37
0.04082


KIAA1797
1292
4977823
T
General
−1.54
0.02497


KIAA1797
1294
10511693
G
Negative
1.24
0.01526


KIAA1797
1295
4579612
C
General
2.05
0.00322


KIAA1797
1296
4977848
A
General
−1.44
0.03549


KIAA1797
1298
7030990
G
Negative
1.22
0.02058


KIAA1797
1299
4977881
A
Negative
1.10
0.02813


KIAA1797
1299
4977881
A
General
1.93
0.00666


KIAA1797
1300
4468020
T
Negative
1.03
0.03784


KIAA1797
1300
4468020
T
General
1.89
0.00718


TEK
1306
10967731
A
Positive
−1.11
0.00607


TEK
1307
1322051
A
Positive
−1.89
0.04390


TEK
1308
2273719
T
General
−2.13
0.02223


TEK
1309
12339867
C
General
−2.01
0.02410


PIP5K1B
1312
7023009
T
Positive
0.81
0.03533


PIP5K1B
1313
12686355
A
Positive
−0.96
0.01543


PIP5K1B
1316
11144133
T
Negative
1.07
0.01861


PIP5K1B
1317
4745375
T
Negative
1.24
0.01342


APBA1
1318
10481751
T
Negative
1.24
0.01613


APBA1
1318
10481751
T
General
1.52
0.03800


TRPM3
1319
1932701
C
Negative
−1.89
0.00415


TRPM3
1322
1337028
T
Negative
−0.93
0.04526


TRPM3
1323
2993010
A
Negative
−1.07
0.02022


PCSK5
1327
7862766
T
General
2.16
0.02270


PCSK5
1329
914367
T
General
−1.37
0.04347


PCSK5
1329
914367
T
Negative
−1.26
0.00808


NTRK2
1335
1187321
A
Negative
1.39
0.02333


NTRK2
1335
1187321
A
General
2.22
0.01051


NTRK2
1336
1187328
G
Negative
1.31
0.03538


NTRK2
1337
1899641
G
General
1.60
0.02849


DAPK1
1338
1927976
G
Negative
−1.00
0.02631


SORCS3
1341
10884026
G
Positive
−1.01
0.04628


SORCS3
1345
2496022
A
General
−1.28
0.04790


CUGBP2
1353
3243
C
General
1.45
0.04284


VTI1A
1355
10885352
T
Positive
−0.91
0.03509


VTI1A
1357
7907012
G
Negative
1.07
0.02739


VTI1A
1360
4145776
G
Negative
0.99
0.04223


ATE1
1363
7086628
C
Positive
−1.09
0.00447


ATE1
1364
1219505
T
Positive
−1.29
0.00067


ATE1
1364
1219505
T
General
−1.21
0.04798


ATE1
1365
1693682
A
General
−1.29
0.04510


ATE1
1366
10732824
A
General
−2.18
0.04567


ATE1
1367
2420970
T
Positive
1.23
0.00122


ATE1
1368
11200251
T
Positive
0.89
0.03135


ATE1
1369
11200260
T
General
1.82
0.04378


CTBP2
1370
4962718
C
Positive
−0.96
0.02804


ARMC3
1371
17440393
A
Positive
1.18
0.01570


ARMC3
1372
11013210
T
Positive
1.11
0.02029


PITRM1
1383
3740607
A
Positive
−0.82
0.03317


PITRM1
1384
4242746
T
Positive
−0.85
0.04967


SLC16A9
1386
6481469
A
General
2.59
0.03613


SLC16A9
1387
3763747
C
Negative
−1.48
0.00519


SLC16A9
1388
2242206
T
Negative
−1.30
0.00719


SLC16A9
1389
1171648
A
Negative
−1.34
0.00846


SLC16A9
1390
1171643
G
Negative
−1.33
0.01007


PRKCQ
1392
9423765
A
Negative
0.96
0.03963


KCNMA1
1401
7897566
C
Positive
1.04
0.01086


KCNMA1
1401
7897566
C
General
1.60
0.01494


KCNMA1
1401
7897566
C
Negative
1.64
0.00034


NRG3
1408
11193681
T
Positive
−1.24
0.02809


NRG3
1410
474496
G
General
1.42
0.03465


NRG3
1411
512064
A
General
1.25
0.04994


GALNTL4
1421
7122801
T
General
−1.49
0.03276


MICAL2
1422
10765929
T
Positive
−1.21
0.00386


MICAL2
1423
2010463
A
Positive
−0.80
0.04857


MICAL2
1424
11822285
T
Positive
−0.84
0.03138


OPCML
1428
10894536
A
Negative
1.68
0.03902


ARNTL
1430
7107711
C
General
−1.86
0.01999


ARNTL
1431
7112233
T
General
−1.70
0.03204


OPCML
1432
7107264
C
General
−1.89
0.04851


SPON1
1435
1507527
C
General
1.48
0.03603


SPON1
1436
2049723
C
General
1.59
0.02683


SPON1
1437
1528668
C
Negative
1.03
0.02759


SPON1
1440
10832170
T
Negative
1.20
0.00721


SPON1
1440
10832170
T
General
1.31
0.04048


SPON1
1441
1406356
A
Negative
1.20
0.00803


SPON1
1441
1406356
A
General
1.40
0.03069


SPON1
1442
7116296
T
General
−1.33
0.04002


SPON1
1442
7116296
T
Negative
−1.03
0.02319


SPON1
1443
11023088
T
Negative
−0.98
0.03476


INSC
1445
1792571
A
Negative
1.62
0.00168


INSC
1445
1792571
A
General
1.63
0.02657


KCNA4
1446
11030913
C
Positive
1.25
0.01607


KCNA4
1447
10835607
A
Positive
1.08
0.03341


STIM1
1448
7952083
C
Positive
−0.85
0.02340


STIM1
1449
10835249
G
Positive
−0.80
0.04205


STIM1
1451
2959068
T
Positive
−0.84
0.04313


TRIM21
1452
1426378
A
Positive
−1.17
0.02572


DLG2
1455
11233564
A
Positive
−2.74
0.00227


DLG2
1456
11233565
C
Positive
−2.49
0.00550


DLG2
1457
6592113
A
Negative
−0.99
0.03066


DLG2
1458
2507850
A
Negative
−0.97
0.04316


DLG2
1459
7108874
T
Negative
−1.22
0.02033


DLG2
1462
2514147
G
Negative
1.58
0.03268


DLG2
1463
10898192
G
Negative
1.66
0.02050


DLG2
1465
1945832
T
Positive
−1.58
0.02446


DLG2
1466
6592202
C
General
−1.35
0.03773


DLG2
1466
6592202
C
Positive
−1.04
0.00980


DLG2
1466
6592202
C
Negative
−0.94
0.03982


DLG2
1467
4451754
A
General
−1.40
0.03522


DLG2
1467
4451754
A
Positive
−1.07
0.00927


DLG2
1468
1943708
C
Positive
−0.89
0.02995


DLG2
1469
11234194
C
Positive
−0.88
0.03398


DLG2
1470
11234221
A
Positive
−1.13
0.00457


DLG2
1471
11234222
A
General
−1.86
0.00385


DLG2
1471
11234222
A
Negative
−1.45
0.00134


DLG2
1472
4943900
C
Negative
1.00
0.02898


DLG2
1474
6592211
A
General
−1.49
0.02007


DLG2
1474
6592211
A
Positive
−1.14
0.00424


DLG2
1475
7101454
C
General
−1.42
0.02852


DLG2
1475
7101454
C
Positive
−1.08
0.00720


DLG2
1476
582652
A
Negative
−1.34
0.04170


ATXN2
1480
1544396
G
Negative
1.09
0.04327


ITPR2
1490
1049376
G
General
−1.44
0.04725


TMEM16B
1491
9645764
C
Negative
−1.14
0.02799


TMEM16B
1499
11612136
A
Positive
1.25
0.01255


KCNC2
1502
10879888
G
Negative
1.74
0.00069


KCNC2
1503
10735985
G
Negative
1.53
0.00116


KCNC2
1504
2471664
C
Negative
2.13
0.00009


NAV3
1508
1677923
G
Negative
1.57
0.04286


NAV3
1510
10859620
G
General
−1.72
0.00858


NAV3
1512
11107419
T
General
−1.46
0.03758


NAV3
1514
1677893
A
Positive
0.79
0.04382


NAV3
1515
7295890
C
General
1.80
0.01110


NAV3
1516
998070
T
General
−1.24
0.04974


NALCN
1524
7337100
G
General
1.38
0.04041


NALCN
1529
9557622
G
General
−1.43
0.02253


ITGBL1
1530
1335594
A
General
−1.55
0.02549


ITGBL1
1532
4772403
T
General
−1.58
0.02099


ITGBL1
1532
4772403
T
Positive
−0.93
0.02766


ITGBL1
1533
7338172
G
General
−1.53
0.04581


ITGBL1
1535
1436261
C
General
−2.13
0.00591


ITGBL1
1536
9518494
T
General
−1.28
0.04145


FGF14
1537
7319796
A
Negative
−1.02
0.02862


FGF14
1538
7334753
C
Positive
0.90
0.02586


FGF14
1539
9518534
T
Positive
0.88
0.02965


MTIF3
1542
7334690
A
Negative
1.11
0.03028


N4BP2L2
1543
206337
A
General
1.98
0.01322


N4BP2L2
1545
169600
A
General
1.67
0.02673


N4BP2L2
1546
208431
G
General
1.52
0.04552


TRPC4
1553
9576332
G
General
1.79
0.00793


TRPC4
1554
7336008
A
General
1.56
0.01718


TRPC4
1555
7338239
G
General
1.45
0.02776


TRPC4
1557
4943529
C
General
1.39
0.03093


TRPC4
1558
1577007
C
Positive
−0.89
0.02610


TRPC4
1559
1556541
C
Positive
−0.89
0.03077


TRPC4
1560
1924378
A
General
−1.28
0.04723


TRPC4
1562
3812837
C
Positive
1.40
0.00147


TRPC4
1562
3812837
C
General
1.62
0.02264


TRPC4
1563
1538146
T
Positive
1.34
0.00176


TRPC4
1564
9594238
C
General
−1.83
0.03205


TRPC4
1564
9594238
C
Positive
−1.23
0.02001


FNDC3A
1567
2181539
G
General
1.87
0.00633


FNDC3A
1568
1983805
G
General
1.57
0.02200


SLAIN1
1573
1343911
A
General
−2.17
0.00964


SLAIN1
1574
1279445
G
Positive
1.50
0.02077


SLAIN1
1575
9318496
T
General
1.71
0.04936


SLAIN1
1576
1146920
C
Positive
1.09
0.01523


SLAIN1
1576
1146920
C
Negative
1.16
0.02302


SLAIN1
1576
1146920
C
General
1.97
0.00651


SLAIN1
1577
8000788
T
General
2.62
0.00773


SLAIN1
1578
10507874
G
General
2.52
0.00977


GPC5
1579
7992120
T
General
1.86
0.03400


GPC5
1584
913005
T
General
−1.58
0.01369


GPC5
1585
9556229
G
Negative
1.77
0.01409


GPC5
1585
9556229
G
General
2.24
0.02954


GPC5
1586
6492630
A
Negative
−0.92
0.04368


GPC5
1587
2148226
G
Negative
1.04
0.02066


GPC6
1588
9516222
G
Positive
1.04
0.04055


GPC6
1593
9524193
T
Negative
1.08
0.03752


GPC6
1594
10492635
C
General
−1.74
0.03755


GPC6
1595
9561551
C
Positive
−0.99
0.03328


NPAS3
1597
8022434
T
Negative
1.56
0.04940


NPAS3
1599
243291
G
Negative
−0.88
0.04978


NPAS3
1601
10133530
A
General
1.84
0.02280


NPAS3
1602
6571604
C
General
−3.41
0.00007


NPAS3
1602
6571604
C
Positive
−1.59
0.00300


NPAS3
1603
6571605
A
General
−2.95
0.00042


NPAS3
1603
6571605
A
Positive
−1.35
0.00913


GNG2
1615
10873056
G
Negative
−2.70
0.01947


SAMD4A
1617
8006657
A
General
1.94
0.00326


SAMD4A
1619
8021151
G
General
1.77
0.00588


PPP2R5E
1620
10137202
C
General
2.11
0.02322


PPP2R5E
1621
972984
C
Negative
−1.55
0.00440


PPP2R5E
1622
1255741
A
Negative
−1.18
0.01323


RGS6
1624
36318
G
General
1.69
0.00984


RGS6
1625
11158926
T
Positive
0.79
0.04420


RGS6
1625
11158926
T
General
1.45
0.02171


RGS6
1629
847241
A
Negative
−1.19
0.00792


RGS6
1631
2283380
T
General
1.34
0.04679


KCNK10
1632
12587003
C
General
1.82
0.00754


KCNK10
1633
12185033
T
Positive
−0.83
0.04727


RPS6KA5
1634
1152423
C
Negative
1.00
0.03427


RPS6KA5
1635
941847
T
Positive
0.90
0.04654


RPS6KA5
1636
1286148
C
Negative
1.38
0.01088


RPS6KA5
1637
7156252
T
Positive
1.07
0.01018


RPS6KA5
1639
1075014
C
Positive
1.07
0.01208


RPS6KA5
1641
7492628
G
Positive
1.20
0.00460


CCDC88C
1642
4904770
T
Positive
−1.48
0.00338


CCDC88C
1644
10131741
G
Positive
−1.20
0.00746


CCDC88C
1646
8007791
A
Positive
−1.20
0.00785


CCDC88C
1647
11160004
C
General
1.67
0.03585


BCL11B
1648
807450
C
Negative
0.98
0.04426


BCL11B
1650
2614463
T
Positive
0.83
0.03335


ATP10A
1651
12442216
T
Negative
−0.91
0.04698


RYR3
1654
2572175
A
General
−1.40
0.02906


RYR3
1654
2572175
A
Positive
−0.95
0.01583


RYR3
1656
1390159
T
General
3.29
0.03110


RYR3
1657
1495284
C
General
3.08
0.03459


RYR3
1658
11638307
A
Negative
−1.26
0.02375


C15ORF41
1661
12443190
G
Negative
1.11
0.01131


C15ORF41
1663
8024344
C
General
−2.87
0.00336


C15ORF41
1663
8024344
C
Negative
−1.79
0.00919


C15ORF41
1664
4923723
C
General
−2.06
0.01990


GLDN
1670
2445781
G
General
1.53
0.03501


GLDN
1671
17648128
A
Positive
1.14
0.00603


GLDN
1672
17648140
G
Positive
1.08
0.00897


RORA
1679
12914584
G
General
−1.51
0.03438


TBC1D2B
1682
2241885
C
Negative
0.98
0.03548


TBC1D2B
1682
2241885
C
General
1.35
0.04053


TBC1D2B
1683
8030999
G
Positive
1.38
0.01666


TBC1D2B
1684
11634607
T
Negative
1.18
0.01249


TBC1D2B
1684
11634607
T
General
1.63
0.01540


ARNT2
1688
4628923
C
Negative
−1.17
0.01854


ARNT2
1688
4628923
C
Positive
−1.06
0.01677


ARNT2
1689
11072931
T
Positive
−1.10
0.04031


ARNT2
1691
4778615
T
Negative
−1.19
0.04811


ARNT2
1691
4778615
T
Positive
−1.13
0.03351


SH3GL3
1692
10520577
T
Positive
1.28
0.00472


TMC5
1694
1985395
C
Negative
0.96
0.04800


TMC5
1694
1985395
C
General
1.66
0.01583


EEF2K
1696
10521118
A
Positive
1.95
0.01256


KIFC3
1698
1559404
T
Negative
−1.53
0.02447


A2BP1
1701
1155959
C
General
1.47
0.02311


WWOX
1708
8061908
C
Positive
−0.84
0.03862


WWOX
1711
11641213
G
Positive
0.80
0.04062


MPHOSPH6
1714
7405231
C
Positive
0.89
0.01797


CDH13
1719
11150496
T
General
1.43
0.02777


CDH13
1722
2059230
T
Positive
0.82
0.04825


CDH13
1730
889491
T
Positive
0.85
0.04749


USP10
1732
8060725
A
Positive
0.82
0.04831


USP10
1732
8060725
A
Negative
1.32
0.00519


USP10
1732
8060725
A
General
1.42
0.03482


CRISPLD2
1733
2641697
C
Positive
1.21
0.00331


CRISPLD2
1734
2641698
T
Positive
1.14
0.00651


CRISPLD2
1735
16974822
G
Positive
−1.40
0.00247


CRISPLD2
1736
774205
G
Positive
0.84
0.04168


CRISPLD2
1738
982994
T
Positive
0.85
0.04298


CRISPLD2
1739
2646107
C
Positive
−1.07
0.01544


DNAH9
1741
16945383
G
Positive
0.80
0.03533


DNAH9
1742
1468501
C
Positive
−1.04
0.02836


CA10
1749
11652641
G
General
−1.95
0.01410


CA10
1749
11652641
G
Positive
−1.08
0.02873


MSI2
1751
8066677
G
General
−2.14
0.00148


MSI2
1752
8067335
A
Positive
−0.83
0.04425


SDK2
1754
1846334
A
Positive
−1.22
0.00294


OSBPL1A
1758
275857
C
Positive
2.65
0.00557


OSBPL1A
1758
275857
C
General
3.17
0.04077


OSBPL1A
1759
641885
T
General
−2.46
0.03775


CHST9
1760
17703962
G
Positive
1.38
0.01471


CHST9
1762
9965371
C
Positive
1.21
0.02735


DLGAP1
1763
9635857
G
Positive
0.94
0.04321


NEDD4L
1766
7243662
G
Positive
1.24
0.01038


NEDD4L
1767
1008899
A
Positive
1.18
0.01254


NEDD4L
1768
4941364
G
Positive
1.14
0.01420


NEDD4L
1769
292444
C
Positive
0.93
0.02791


NEDD4L
1770
525839
A
Positive
0.90
0.03453


NEDD4L
1771
11663936
T
Negative
−1.18
0.03859


NEDD4L
1772
17064977
C
Negative
1.10
0.03738


NEDD4L
1773
11152073
A
Negative
1.07
0.04122


CDH7
1781
8092259
G
Negative
1.38
0.00316


CDH7
1781
8092259
G
General
1.41
0.03486


CDH7
1782
7228669
T
General
1.34
0.04448


CDH7
1783
1942832
A
Negative
1.26
0.00745


CDH7
1784
1942831
G
General
1.34
0.04464


CDH7
1786
1484725
T
Negative
1.24
0.00820


CDH7
1790
1564815
C
Negative
2.42
0.02279


DOK6
1791
12961718
C
General
1.58
0.02195


DOK6
1792
8097743
G
Positive
−0.85
0.02753


DOK6
1793
4426448
G
Positive
0.94
0.01905


DOK6
1794
12605879
G
Positive
0.90
0.02201


MBP
1796
11660442
A
Negative
1.07
0.02397


PTPRM
1797
495288
G
Negative
2.51
0.02561


PTPRM
1798
8089695
C
Negative
2.27
0.00638


KIAA0802
1803
12386117
A
General
−2.31
0.00964


KIAA0802
1803
12386117
A
Positive
−1.32
0.01762


KIAA0802
1804
7235093
A
Negative
2.20
0.00394


LDLR
1805
8110695
A
General
1.72
0.02348


LDLR
1807
1433099
A
Positive
−0.88
0.04421


MACROD2
1809
6079395
G
Positive
0.84
0.03441


MACROD2
1809
6079395
G
Negative
0.99
0.02883


MACROD2
1810
6079910
C
General
−2.02
0.04025


KIF16B
1813
6043875
C
General
−1.62
0.01173


KIF16B
1818
6135739
G
General
−1.34
0.04077


KIF16B
1821
6034464
A
General
−1.40
0.02717


KIF16B
1823
12624938
A
General
1.83
0.03290


KIF16B
1826
6075069
T
General
2.46
0.00261


KIF16B
1827
6080359
C
Negative
−1.16
0.02720


PTPRT
1832
6065432
T
Negative
−1.35
0.00638


PTPRT
1833
746413
C
Negative
−1.04
0.02087


PTPRT
1833
746413
C
Positive
1.15
0.00399


PTPRT
1834
6065434
T
Negative
−1.27
0.00885


PTPRT
1835
6016688
T
Positive
0.98
0.03708


PTPRT
1836
6065487
A
Positive
−1.00
0.01421


PTPRT
1838
2017914
G
General
1.40
0.04442


PTPRT
1839
6072869
G
Negative
1.24
0.01854


KCNB1
1841
1961192
T
Negative
−0.95
0.03860


KCNB1
1844
6095546
A
General
−1.48
0.04378


KCNB1
1844
6095546
A
Positive
−0.93
0.04204


KCNB1
1845
4647
T
Positive
−0.95
0.03795


CDH4
1846
6028127
G
General
−1.41
0.04280


CDH4
1847
4812313
G
General
−1.42
0.04339


FERMT1
1855
8121939
G
General
−1.34
0.04231


PLCB1
1856
6055577
A
Positive
1.06
0.04019


PLCB1
1857
2235212
A
Positive
0.95
0.04340


PLCB4
1859
6077505
C
Negative
−1.17
0.01308


PLCB4
1860
6039424
G
Negative
−0.92
0.04737


C21ORF37
1861
12483129
C
Negative
0.97
0.02832


SLC37A1
1872
381899
A
Negative
−1.39
0.00591


SGSM1
1874
5760752
C
Negative
0.97
0.04133


ARFGAP3
1876
6002963
G
General
−1.76
0.00781


ARFGAP3
1877
738536
A
General
1.37
0.02863


PACSIN2
1882
4140554
C
General
−2.05
0.00135


PACSIN2
1883
7291153
C
General
−1.95
0.00238


PACSIN2
1887
737782
G
Negative
1.16
0.01019


PACSIN2
1887
737782
G
General
1.70
0.00803


PACSIN2
1888
2284097
C
General
−1.87
0.00345


PACSIN2
1889
738379
A
General
−1.71
0.00737


PACSIN2
1889
738379
A
Negative
−0.96
0.03380


TTLL1
1891
135001
C
Negative
0.99
0.02599


TTLL1
1891
135001
C
General
1.26
0.04582


TTLL1
1892
135002
C
Negative
0.96
0.03155


TTLL1
1892
135002
C
General
1.25
0.04902


EFCAB6
1893
137160
G
Positive
0.97
0.01465


EFCAB6
1893
137160
G
General
1.35
0.03556
















TABLE 3







Alleles Influencing Individual PANSS Items














SEQ ID
NCBI

PANSS




Gene
NO:
RS #
Allele
Item
Beta
P
















KIF1B
1
3748577
G
G15
0.24
0.0074930


KIF1B
2
2297881
C
N4
0.90
0.0098590


KIF1B
3
1555849
G
N1
0.33
0.0023450


KIF1B
3
1555849
G
G15
0.24
0.0082990


KIF1B
4
3748578
A
N1
0.35
0.0016060


SYT6
5
611514
A
G2
0.23
0.0088800


SYT6
5
611514
A
P4
0.20
0.0070350


NGF
6
6327
A
N1
−0.30
0.0021770


SLC22A15
8
2488433
T
P7
−0.40
0.0060930


SLC22A15
9
7547928
T
G8
−0.17
0.0031870


SLC22A15
10
2051060
C
G8
−0.16
0.0047370


SLC22A15
11
17035177
T
N1
0.56
0.0084980


PTGFRN
12
943371
C
G4
−0.77
0.0029300


PTGFRN
13
12078461
A
G7
0.65
0.0051320


PTGFRN
14
4641299
G
P5
−0.27
0.0057720


PTGFRN
15
3829881
A
G1
−0.28
0.0025710


RP1-21O18.1
18
10803343
G
G14
0.95
0.0002941


RP1-21O18.1
19
1000313
G
G14
0.27
0.0003008


RP1-21O18.1
20
4501834
C
G14
0.22
0.0031970


RP1-21O18.1
21
2221926
T
G14
0.28
0.0034020


RP1-21O18.1
21
2221926
T
G13
0.32
0.0056050


ATF6
23
10918029
A
G11
0.41
0.0033720


ATF6
24
7552420
C
N1
0.51
0.0021620


OLFML2B
26
2499836
T
N4
0.30
0.0026610


OLFML2B
27
12025136
C
G16
0.32
0.0020010


OLFML2B
27
12025136
C
N6
0.29
0.0071570


FAM78B
28
6662013
T
G5
0.21
0.0039550


FAM78B
29
10800181
G
G11
−0.22
0.0086260


RALGPS2
31
4652319
T
N7
−0.25
0.0043700


RALGPS2
31
4652319
T
G15
−0.25
0.0065890


RALGPS2
32
12076230
G
G12
−0.26
0.0085520


KCNK2
33
10864143
A
N5
0.29
0.0068860


KCNK2
34
2363557
A
G10
−0.18
0.0078510


KCNK2
35
2363567
T
G10
−0.18
0.0085910


KCNK2
36
6684084
G
N5
0.27
0.0087360


KCNK2
37
10779651
C
N6
0.36
0.0001705


KCNK2
37
10779651
C
N5
0.27
0.0089470


KCNK2
38
1112101
G
N6
0.36
0.0005514


KCNK2
39
11120527
T
G5
0.22
0.0049310


USH2A
40
2211125
T
N6
0.32
0.0023270


USH2A
41
1339411
T
N6
0.29
0.0077170


USH2A
42
7548730
C
N7
0.22
0.0094820


USH2A
43
6665313
A
P3
0.46
0.0025330


USH2A
44
12403674
T
P3
0.44
0.0041770


USH2A
47
386654
T
G11
0.26
0.0035990


USH2A
48
680410
G
G11
0.25
0.0051510


USH2A
49
12030122
C
N5
0.47
0.0072360


ESRRG
50
6658528
T
G5
−0.23
0.0010100


ESRRG
51
6604635
A
G5
−0.21
0.0022990


ESRRG
51
6604635
A
G10
−0.16
0.0089390


ESRRG
52
10218694
A
P7
0.17
0.0069140


ESRRG
53
12088947
A
P7
0.18
0.0074210


ESRRG
54
1498276
G
G14
0.21
0.0016130


ESRRG
55
17670802
G
G7
0.24
0.0022500


EPHB2
57
10799762
C
G14
0.32
0.0029190


EPHB2
58
309473
T
N4
−0.28
0.0030420


SLC35F3
59
10495346
T
P7
0.28
0.0061170


RYR2
60
1806641
C
N3
0.25
0.0028740


RYR2
61
637520
T
G11
−0.22
0.0048860


RYR2
62
2275287
A
G14
0.19
0.0067060


RYR2
63
10802596
T
G13
0.22
0.0100000


RYR2
63
10802596
T
G14
0.20
0.0034720


RYR2
65
3924864
C
G13
0.37
0.0057310


RYR2
65
3924864
C
G14
0.29
0.0071300


RYR2
66
2779400
A
G3
−0.29
0.0043720


RYR2
66
2779400
A
G13
−0.21
0.0086620


RYR2
67
12141182
T
G5
−0.20
0.0091040


RYR2
68
2819743
T
G5
−0.23
0.0042810


CHRM3
69
16838637
G
G5
0.20
0.0017450


CHRM3
70
1867264
T
G5
0.21
0.0019340


CHRM3
70
1867264
T
G7
0.25
0.0010800


CHRM3
71
10802795
C
G7
0.25
0.0013130


CHRM3
72
6663632
A
G7
0.22
0.0030570


CHRM3
73
6657343
A
G7
−0.20
0.0082860


CHRM3
74
10802801
A
G7
0.22
0.0042560


CHRM3
75
479933
A
G3
−0.34
0.0058350


FMN2
76
12145060
A
G4
0.22
0.0084360


FMN2
76
12145060
A
G2
0.27
0.0039240


FMN2
77
12021945
C
G2
0.25
0.0070300


FMN2
78
9970045
A
G6
0.30
0.0096920


FMN2
80
7520065
G
P4
0.21
0.0060730


FMN2
81
897662
T
P4
0.21
0.0045960


FMN2
82
10926188
G
P4
0.21
0.0051100


FMN2
84
16832176
C
G16
−0.27
0.0094940


FMN2
85
11799544
T
G13
0.38
0.0072610


FMN2
86
10926257
T
G13
0.37
0.0087780


RGS7
87
12038803
A
G11
−0.25
0.0055160


RGS7
87
12038803
A
N1
−0.33
0.0025720


CLIC4
89
6604978
C
G2
−0.30
0.0016950


CLIC4
90
9332415
T
G2
−0.29
0.0022220


AGBL4-
91
319965
A
N3
0.24
0.0061090


C1ORF165








AGBL4-
91
319965
A
N7
0.22
0.0068310


C1ORF165








AGBL4-
92
1934395
G
G3
−0.28
0.0094430


C1ORF165








AGBL4-
93
4285747
C
G6
−0.28
0.0038460


C1ORF165








AGBL4-
94
12023014
C
G6
−0.27
0.0053990


C1ORF165








AGBL4-
95
12043418
T
G6
−0.27
0.0062110


C1ORF165








AGBL4-
96
3121273
G
G7
−0.20
0.0088860


C1ORF165








SCP2
98
3766762
C
G15
−0.53
0.0080520


SCP2
98
3766762
C
G11
−0.55
0.0046630


LRP8
99
1288523
A
P6
0.28
0.0061260


ELTD1
101
4650634
A
G9
−0.32
0.0088300


PRKACB
102
3915908
T
P2
−0.28
0.0031410


PRKACB
103
3903924
G
P2
0.27
0.0056920


HPCAL1
105
16856020
T
N3
0.40
0.0013070


HPCAL1
105
16856020
T
N5
0.42
0.0044340


KCNF1
107
4669651
T
G6
0.40
0.0006391


NAP5
109
4283469
A
P7
−0.41
0.0062590


NAP5
109
4283469
A
P4
−0.49
0.0066410


NAP5
110
1434231
C
G14
0.19
0.0081370


RAB3GAP1
111
10174944
T
G6
0.38
0.0067730


NXPH2
116
17651262
A
G6
0.30
0.0020160


LRP1B
117
1486963
C
G6
−0.40
0.0001314


LRP1B
118
13021003
C
G6
−0.33
0.0008647


LRP1B
119
10469593
C
G6
−0.32
0.0011370


LRP1B
120
12479163
A
G6
−0.45
0.0000142


LRP1B
120
12479163
A
P6
−0.31
0.0031180


LRP1B
121
2171107
A
G13
0.22
0.0075710


LRP1B
122
9283437
C
P1
0.31
0.0061220


LRP1B
123
4954907
T
G6
0.28
0.0082880


LRP1B
124
11681928
A
N4
−0.26
0.0089250


LRP1B
125
12616665
G
P6
−0.40
0.0007633


LRP1B
126
10496897
A
N7
0.24
0.0063040


LRP1B
127
12990449
C
P6
−0.38
0.0012510


KYNU
129
2043944
T
N2
0.31
0.0003813


KYNU
129
2043944
T
N4
0.37
0.0001105


KYNU
129
2043944
T
G12
0.27
0.0038560


KYNU
129
2043944
T
N3
0.27
0.0012600


KYNU
130
10176234
A
G13
0.22
0.0045350


KYNU
130
10176234
A
G12
0.26
0.0062530


KYNU
130
10176234
A
N2
0.29
0.0008502


KYNU
130
10176234
A
N3
0.26
0.0022680


KYNU
131
351673
T
N2
0.21
0.0095860


KYNU
131
351673
T
N4
0.34
0.0002347


KYNU
132
6429997
C
N4
0.28
0.0035140


KYNU
133
6732786
G
G6
−0.38
0.0018490


ARHGAP15
134
1869009
A
N6
0.27
0.0069890


ARHGAP15
135
11895997
A
N1
−0.29
0.0031330


ARHGAP15
136
17814502
A
P2
0.40
0.0003225


ARHGAP15
137
10048784
T
G3
−0.29
0.0084780


ARHGAP15
138
13011344
G
G16
−0.29
0.0082560


ARHGAP15
139
3795872
T
G16
−0.29
0.0082980


ARHGAP15
141
13031917
C
P3
0.30
0.0079410


FMNL2
147
1561267
C
P7
−0.27
0.0097290


PKP4
156
2007493
G
G5
−0.20
0.0056870


PKP4
158
2528582
G
N7
−0.24
0.0036000


PKP4
158
2528582
G
G5
−0.20
0.0057130


PKP4
158
2528582
G
P2
−0.25
0.0081930


PLA2R1
160
949753
G
P2
−0.31
0.0071790


PLA2R1
161
3828324
C
N1
−0.25
0.0083020


PLA2R1
161
3828324
C
N6
−0.27
0.0023180


PLA2R1
162
2667012
C
N6
0.26
0.0054070


PLA2R1
162
2667012
C
N1
0.27
0.0049360


PLA2R1
163
4665145
T
G11
0.25
0.0095000


PLA2R1
163
4665145
T
G3
0.34
0.0030390


SCN3A
165
11677254
C
G7
−0.24
0.0025100


SCN3A
165
11677254
C
N4
−0.28
0.0041850


SCN3A
165
11677254
C
N1
−0.28
0.0070540


SCN3A
165
11677254
C
N2
−0.29
0.0009855


SCN1A
166
6731591
C
G7
−0.28
0.0056940


SCN1A
168
497594
G
G7
0.25
0.0045790


SCN9A
169
7589835
A
G5
0.28
0.0082980


SCN9A
169
7589835
A
N1
0.41
0.0084640


SCN9A
169
7589835
A
G7
0.35
0.0039360


SCN9A
173
4447616
C
P2
0.26
0.0067540


SCN9A
174
6732627
A
G4
−0.25
0.0025060


SCN7A
175
5024296
T
G13
0.22
0.0078780


SCN7A
175
5024296
T
G4
−0.24
0.0055560


CERKL
176
4018756
A
N5
0.27
0.0088890


PDE1A
177
13400054
C
N4
−0.41
0.0005951


PDE1A
178
3769794
C
N3
0.32
0.0022070


PDE1A
179
3769789
G
N3
0.29
0.0088030


PDE1A
180
2623438
G
N4
−0.40
0.0009703


PDE1A
180
2623438
G
N2
−0.32
0.0032780


PDE1A
181
4666828
A
N4
−0.38
0.0016920


PDE1A
181
4666828
A
N2
−0.29
0.0082390


PDE1A
182
6726543
G
G1
0.26
0.0067830


PDE1A
183
833142
A
G1
−0.26
0.0043210


PDE1A
183
833142
A
G8
−0.15
0.0089830


PDE1A
183
833142
A
P1
−0.31
0.0047960


PDE1A
184
833119
C
G4
0.29
0.0009323


PDE1A
185
12988258
A
G4
0.26
0.0040120


PDE1A
186
6736414
T
G1
0.27
0.0083740


PDE1A
187
16823124
A
G6
−0.29
0.0047680


PDE1A
188
10497597
T
G6
−0.28
0.0059250


PDE1A
189
2887202
A
G1
−0.25
0.0072430


PDE1A
189
2887202
A
P1
−0.33
0.0039330


PDE1A
190
9332425
T
G3
−0.32
0.0016990


PDE1A
190
9332425
T
P6
−0.27
0.0085150


PDE1A
190
9332425
T
G6
−0.28
0.0047890


ALS2
192
2302610
G
G10
−0.26
0.0023280


PARD3B
193
1477179
T
G14
0.21
0.0092930


PARD3B
194
2098462
C
G14
0.20
0.0074160


PARD3B
195
2878473
C
G4
−0.34
0.0010800


PARD3B
196
1540369
G
G5
0.23
0.0027160


PARD3B
196
1540369
G
G12
0.28
0.0077080


PARD3B
197
2704638
G
G5
0.30
0.0017260


PARD3B
198
3845806
A
G5
0.20
0.0065550


PARD3B
198
3845806
A
P5
0.30
0.0017910


PARD3B
199
10490293
T
G12
0.26
0.0095200


PARD3B
200
1606237
T
P5
0.28
0.0026520


PARD3B
201
698906
T
P5
0.37
0.0033850


NRP2
203
955395
T
G13
−0.25
0.0012450


NRP2
203
955395
T
N1
−0.29
0.0036830


NRP2
203
955395
T
N2
−0.27
0.0018830


NRP2
204
13396083
C
G13
−0.21
0.0066730


NRP2
205
6435306
A
N1
−0.27
0.0057680


PIP5K3
206
7586020
C
G5
−0.20
0.0049350


PIP5K3
207
10497899
T
P1
−0.88
0.0035790


PIP5K3
207
10497899
T
P6
−0.76
0.0059020


ERBB4
208
11901831
C
G10
0.27
0.0075730


ERBB4
210
1992029
G
G11
−0.26
0.0065430


COL4A3
215
2178631
C
G12
−0.31
0.0010500


COL4A3
215
2178631
C
P5
−0.24
0.0061530


DNER
216
6733289
G
G10
−0.16
0.0063000


DNER
217
12611671
C
G14
0.20
0.0040080


ECEL1
218
12616972
C
P5
0.29
0.0016390


CHRNG
219
1201451
T
G15
−0.25
0.0060940


SAG
220
2304773
A
P7
0.28
0.0070970


SAG
220
2304773
A
N4
0.45
0.0030830


SAG
220
2304773
A
N6
0.47
0.0020440


KLHL29
222
747345
A
N4
−0.29
0.0025940


KLHL29
222
747345
A
G16
−0.27
0.0048360


KLHL29
222
747345
A
P5
−0.25
0.0062440


KLHL29
225
6727901
G
N4
−0.30
0.0017570


KLHL29
225
6727901
G
G16
−0.25
0.0086370


KCNK3
228
7584568
G
G13
−0.21
0.0081610


KCNK3
229
1627854
G
G13
−0.21
0.0090110


DPYSL5
230
486582
C
G10
0.17
0.0048990


DPYSL5
232
3769138
G
G10
0.17
0.0050320


BRE
233
10189434
T
G6
0.31
0.0046780


BRE
235
10189899
A
G1
−0.27
0.0030600


BRE
236
1546029
C
G10
0.18
0.0068080


CRIM1
237
6757374
T
P7
−0.33
0.0043140


CRIM1
237
6757374
T
G10
0.29
0.0061260


CRIM1
240
888074
G
N6
−0.25
0.0071850


CRIM1
242
2160367
C
N6
−0.26
0.0061580


CRIM1
243
848556
T
P1
−0.31
0.0039740


CRIM1
244
848532
C
G1
−0.31
0.0013040


CRIM1
245
848531
A
G1
−0.28
0.0038690


SLC8A1
247
2072531
T
P6
−0.29
0.0028790


SLC8A1
247
2072531
T
P1
−0.29
0.0079460


SLC8A1
248
417591
G
N5
0.31
0.0096150


HAAO
252
6738169
G
N1
−0.29
0.0060670


PLEKHH2
253
17414362
A
G10
−0.24
0.0007199


PLEKHH2
253
17414362
A
G11
−0.25
0.0074160


PLEKHH2
254
2288710
C
G14
0.35
0.0070470


PLEKHH2
254
2288710
C
G11
0.53
0.0010930


PLEKHH2
254
2288710
C
N5
0.52
0.0099950


PLEKHH2
254
2288710
C
N7
0.52
0.0012830


PLEKHH2
255
7570252
A
G10
−0.18
0.0043850


PLEKHH2
256
10165660
C
G10
−0.17
0.0061410


C2ORF34
257
786616
C
N7
−0.31
0.0011430


C2ORF34
257
786616
C
P2
−0.31
0.0047180


C2ORF34
257
786616
C
G15
−0.28
0.0038400


C2ORF34
258
786626
C
G9
−0.28
0.0042620


C2ORF34
259
1067343
A
P2
−0.29
0.0062780


C2ORF34
260
1584885
C
G9
−0.26
0.0023430


C2ORF34
262
1067367
A
G9
−0.27
0.0059360


C2ORF34
263
1065786
T
G9
−0.28
0.0048720


C2ORF34
265
698792
A
G15
−0.28
0.0049980


C2ORF34
265
698792
A
N7
−0.27
0.0038670


C2ORF34
268
2341457
A
G9
−0.24
0.0058060


C2ORF34
269
1377906
G
G15
−0.22
0.0083300


C2ORF34
270
7567272
A
P2
−0.25
0.0057880


C2ORF34
271
4953105
G
G9
−0.23
0.0077590


C2ORF34
272
10445928
C
G9
−0.23
0.0090270


C2ORF34
273
4953122
G
P2
−0.24
0.0091370


C2ORF34
274
7603180
C
N7
0.29
0.0047560


C2ORF34
275
3738980
C
N2
−0.37
0.0020550


C2ORF34
275
3738980
C
G7
−0.40
0.0002342


C2ORF34
275
3738980
C
N4
−0.37
0.0046210


C2ORF34
275
3738980
C
N7
−0.30
0.0063550


C2ORF34
275
3738980
C
G16
−0.40
0.0017670


C2ORF34
275
3738980
C
N5
−0.47
0.0008419


PRKCE
276
666334
T
G10
0.18
0.0080830


PRKCE
277
6748375
C
N3
0.27
0.0010920


PRKCE
278
1020445
C
G1
−0.27
0.0042010


EPAS1
279
4953340
C
N4
−0.28
0.0027890


FBXO11
280
12463595
T
G10
0.19
0.0030790


FBXO11
281
12620679
C
G13
−0.21
0.0075070


PSME4
282
805391
T
G7
−0.24
0.0015200


PSME4
282
805391
T
N6
−0.25
0.0054780


PSME4
282
805391
T
N1
−0.26
0.0068310


PSME4
282
805391
T
G13
−0.23
0.0020840


PSME4
282
805391
T
G15
−0.27
0.0008523


PSME4
282
805391
T
N7
−0.25
0.0012910


PSME4
283
805330
A
N7
−0.22
0.0047520


PSME4
284
805360
T
G10
−0.17
0.0059760


PSME4
284
805360
T
N7
−0.21
0.0092440


PSME4
285
3731967
A
G7
−0.20
0.0099430


PSME4
286
10183655
T
N6
−0.25
0.0074630


ACYP2
290
17045754
C
G1
−0.37
0.0050170


CCDC85A
291
4672096
G
P2
−0.42
0.0097740


CCDC85A
292
1159916
G
N5
0.28
0.0090120


CCDC85A
294
2111470
C
G4
0.25
0.0045680


CCDC85A
295
1030091
C
G14
0.40
0.0099130


OTX1
296
11125946
A
N7
0.23
0.0074160


AAK1
297
9789387
A
G9
−0.25
0.0048970


AAK1
298
12471316
G
N5
0.25
0.0095590


AAK1
299
12622388
G
G9
−0.27
0.0064650


CTNNA2
300
7597912
T
N7
−0.24
0.0090330


CTNNA2
301
2566539
T
G15
−0.24
0.0077290


CTNNA2
305
1319241
A
P3
−0.48
0.0040350


CTNNA2
307
895388
T
P3
−0.60
0.0030370


CTNNA2
308
7589069
C
N1
0.47
0.0019290


CTNNA2
308
7589069
C
N5
0.45
0.0037440


CTNNA2
308
7589069
C
G7
0.38
0.0016780


CTNNA2
309
1444539
C
G7
0.31
0.0074740


CTNNA2
310
1434064
G
G7
−0.22
0.0058730


C2ORF46
313
7577544
G
P4
−0.46
0.0003160


C2ORF46
314
3111414
C
G8
0.19
0.0091600


C2ORF46
314
3111414
C
G15
0.33
0.0013790


C2ORF46
315
2914424
T
G15
0.36
0.0041090


DDEF2
316
10204214
T
G15
0.38
0.0022250


INPP4A
317
17031905
G
G14
0.20
0.0076740


INPP4A
318
2278214
A
P7
0.20
0.0057790


ATP2B2
319
241508
A
P1
0.30
0.0068740


PLCXD2
320
1513331
C
G15
0.32
0.0063110


PLCXD2
321
6788543
C
P1
−0.30
0.0074850


PLCXD2
322
6796087
T
P1
−0.30
0.0075950


PLCXD2
323
6784753
C
G15
−0.23
0.0056890


PLCXD2
323
6784753
C
P1
−0.29
0.0085480


PLCXD2
323
6784753
C
P2
−0.27
0.0032880


PLCXD2
324
12490166
A
P3
0.34
0.0033240


CDGAP
325
6438523
A
P6
0.27
0.0091720


STXBP5L
326
17249426
A
G6
−0.34
0.0064750


KALRN
327
16835912
C
G11
0.23
0.0050790


CNTN6
328
3772339
T
P1
−0.32
0.0053750


CNTN6
329
4286413
T
N1
0.31
0.0018330


CPNE4
332
9812534
C
N5
−0.29
0.0051580


CPNE4
336
9289395
G
G13
0.22
0.0086320


CPNE4
336
9289395
G
N4
0.27
0.0089350


CPNE4
336
9289395
G
N2
0.27
0.0032240


CPNE4
336
9289395
G
N5
0.29
0.0089530


CPNE4
337
17297521
C
G13
0.37
0.0016770


CPNE4
337
17297521
C
N6
0.40
0.0047080


CPNE4
338
6806898
T
N6
0.37
0.0070530


CPNE4
338
6806898
T
G13
0.35
0.0021460


RAB6B
340
6765093
G
N2
0.23
0.0064270


RAB6B
340
6765093
G
P6
0.27
0.0053900


EPHB1
344
36172
C
P2
0.25
0.0056950


EPHB1
346
7644369
T
P2
0.28
0.0028780


EPHB1
347
4955522
A
P2
0.26
0.0054500


EPHB1
348
185257
T
P5
0.26
0.0033630


EPHB1
349
9825380
T
P5
0.28
0.0022360


EPHB1
350
4955524
A
P2
0.26
0.0057940


EPHB1
351
936323
T
P2
0.25
0.0073630


EPHB1
351
936323
T
P5
0.27
0.0025230


EPHB1
352
1870196
T
G8
0.18
0.0049260


CNTN6
353
1479530
G
G11
−0.23
0.0059820


CNTN6
354
2291100
C
N3
−0.23
0.0074750


CLSTN2
355
13086670
G
G15
0.24
0.0047240


CLSTN2
356
9836487
G
G15
0.23
0.0061830


CLSTN2
356
9836487
G
N5
0.27
0.0085550


CLSTN2
357
7632885
G
N3
0.24
0.0069350


CLSTN2
358
4683499
G
G15
0.23
0.0066830


CLSTN2
359
6439927
C
G7
0.23
0.0085600


CLSTN2
359
6439927
C
N3
0.25
0.0072760


CLSTN2
360
4683509
G
G2
−0.32
0.0018500


CLSTN2
361
347975
G
P6
−0.31
0.0030380


CLSTN2
361
347975
G
G2
−0.27
0.0042070


CLSTN2
362
347973
A
G2
−0.25
0.0091370


CLSTN2
362
347973
A
P6
−0.28
0.0077160


SPSB4
364
7620622
A
G7
0.30
0.0014580


SLC6A6
365
1156567
C
P5
0.37
0.0055120


SLC6A6
365
1156567
C
N1
−0.41
0.0063420


DAZL
366
4685357
T
G8
0.20
0.O015550


DAZL
367
6787063
G
P3
−0.30
0.0078670


DAZL
368
13064112
G
P3
0.32
0.0098920


PLD1
373
181715
T
G8
−0.15
0.0078600


PLD1
374
2290480
A
P6
0.31
0.0098860


PLD1
374
2290480
A
G6
0.31
0.0080730


PLD1
375
16856569
G
G6
0.31
0.0092840


PLD1
375
16856569
G
P6
0.31
0.0099570


PLD1
376
4446237
T
P6
0.29
0.0040360


NLGN1
381
12636180
T
P1
0.33
0.0097910


NLGN1
382
10936780
G
G13
−0.41
0.0042770


NLGN1
383
12634066
A
G13
−0.39
0.0061200


NLGN1
384
7614469
C
P7
−0.21
0.0091360


HTR3D
385
939334
G
N3
0.27
0.0025300


HTR3D
385
939334
G
G13
0.25
0.0024460


HTR3D
386
6779545
A
N6
0.28
0.0041680


HTR3D
386
6779545
A
G13
0.27
0.0009273


HTR3D
386
6779545
A
N3
0.29
0.0010920


HTR3D
386
6779545
A
G15
0.23
0.0083220


HTR3E
387
11718245
A
P5
−0.32
0.0044630


LEPREL1
388
1719615
T
G6
0.32
0.0083790


LEPREL1
389
1666486
A
G6
0.32
0.0083790


LEPREL1
390
1526031
C
P4
−0.33
0.0004817


LEPREL1
391
1522930
G
P4
−0.28
0.0039020


LEPREL1
392
2667709
G
P4
−0.22
0.0098150


IL1RAP
393
2885545
G
N2
−0.50
0.0025450


IL1RAP
394
6791374
C
N7
−0.46
0.0032290


IL1RAP
394
6791374
C
N2
−0.44
0.0081860


IL1RAP
394
6791374
C
N4
−0.58
0.0013920


LRRC15
395
6799698
A
G8
−0.21
0.0075670


UBXD7
398
3973
T
G15
−0.25
0.0060970


CNTN4
399
6785626
A
P4
0.20
0.0097310


RARB
400
17525900
C
G13
−0.38
0.0041060


RARB
400
17525900
C
N3
−0.40
0.0049540


RARB
401
1286738
T
P7
0.26
0.0012390


RARB
402
17526942
T
G5
−0.29
0.0098670


RARB
403
1656463
A
P7
0.28
0.0012580


CNTN4
404
12494838
G
N2
0.26
0.0060730


CNTN4
405
1420020
G
N7
0.39
0.0062210


CNTN4
406
163352
G
G12
−0.34
0.0057050


CLASP2
407
4679039
C
P4
−0.22
0.0035350


CLASP2
408
6772776
T
P4
−0.21
0.0064810


CLASP2
409
9862261
G
P4
−0.19
0.0096500


CLASP2
411
7641020
G
P4
−0.20
0.0084190


ARPP-21
412
2305234
A
G11
0.38
0.0045210


STAC
413
17186340
T
G13
0.35
0.0100000


STAC
413
17186340
T
P7
0.34
0.0024810


STAC
413
17186340
T
P4
0.45
0.0005653


ULK4
414
7618902
G
P5
0.26
0.0064860


ULK4
415
1495698
C
G15
0.25
0.0039090


ULK4
415
1495698
C
G13
0.24
0.0032920


ULK4
416
1691964
T
N7
0.25
0.0015390


ULK4
417
1691966
G
N7
0.24
0.0023360


ULK4
418
1691998
G
N7
0.23
0.0032560


ULK4
418
1691998
G
G10
0.16
0.0069320


ULK4
418
1691998
G
G8
0.15
0.0081990


ULK4
419
13069172
G
N7
0.22
0.0053180


ULK4
419
13069172
G
G15
0.23
0.0039650


ULK4
419
13069172
G
G13
0.22
0.0039610


ULK4
420
2272007
A
G11
0.31
0.0064130


ITPR1
421
9880562
T
N6
0.26
0.0064910


ITPR1
422
7432768
G
G12
−0.24
0.0092850


ITPR1
422
7432768
G
G6
0.32
0.0007960


SEMA3F
423
2624837
T
P3
−0.51
0.0045480


SEMA3F
425
12632110
A
N5
−0.32
0.0031660


CACNA2D3
427
11130396
T
P7
−0.19
0.0075930


CACNA2D3
428
4928040
A
N5
−0.30
0.0094690


ERC2
429
815453
G
G15
−0.26
0.0063400


ERC2
430
2132237
C
N4
0.29
0.0028920


ERC2
431
11130482
C
G15
−0.31
0.0029250


ERC2
432
2168818
T
G14
0.23
0.0076590


ERC2
434
9810436
A
N5
0.39
0.0013900


ERC2
434
9810436
A
P1
−0.35
0.0075910


ERC2
436
4974168
C
N5
0.38
0.0025340


ERC2
437
1485672
T
N5
−0.34
0.0015390


ERC2
439
1869156
G
N5
−0.29
0.0046120


ERC2
441
4974134
A
N5
−0.30
0.0061560


ERC2
442
4974200
G
N5
−0.29
0.0073480


ERC2
445
1546060
C
N1
−0.30
0.0031360


ERC2
445
1546060
C
N6
−0.30
0.0015960


ERC2
446
6805882
C
N6
−0.30
0.0020990


ERC2
446
6805882
C
N2
−0.27
0.0020750


ERC2
447
885211
A
G5
−0.19
0.0064520


ERC2
448
9814545
A
N1
−0.31
0.0052050


ERC2
449
1878270
C
G7
−0.22
0.0046770


ERC2
450
9873381
A
N1
−0.29
0.0046080


ERC2
450
9873381
A
G7
−0.26
0.0014620


ERC2
450
9873381
A
N2
−0.23
0.0089980


ERC2
451
9881216
T
G7
−0.21
0.0068840


ERC2
451
9881216
T
N1
−0.30
0.0027270


ERC2
452
7633140
A
G7
−0.21
0.0072940


ERC2
453
7627759
C
N1
−0.30
0.0032360


ERC2
453
7627759
C
G7
−0.21
0.0075200


FHIT
454
639244
G
G5
0.20
0.0050940


FHIT
454
639244
G
N4
0.29
0.0039900


FHIT
454
639244
G
G7
0.24
0.0035580


FHIT
454
639244
G
G16
0.26
0.0072680


FHIT
454
639244
G
N2
0.23
0.0098560


FHIT
454
639244
G
N6
0.32
0.0014180


FHIT
455
2253211
C
N3
0.22
0.0081450


PTPRG
459
624755
G
P1
0.29
0.0074050


PTPRG
459
624755
G
G9
0.24
0.0084740


PTPRG
460
3821880
A
N5
−0.27
0.0086610


PTPRG
460
3821880
A
G1
−0.24
0.0070780


PTPRG
461
1713531
C
G15
−0.25
0.0043390


PTPRG
462
9683044
C
N5
−0.35
0.0032220


PTPRG
463
7651505
G
G1
0.28
0.0023500


PTPRG
464
1388612
A
G3
−0.33
0.0081380


PTPRG
465
1388613
C
N5
0.38
0.0008341


PTPRG
465
1388613
C
G3
−0.38
0.0006554


PTPRG
466
2242352
G
N5
0.34
0.0012430


CADPS
467
1355551
T
N5
0.43
0.0012130


CADPS
467
1355551
T
N3
0.34
0.0022110


CADPS
468
9843019
T
G3
−0.38
0.0018590


CADPS
469
9311842
T
N6
0.32
0.0034610


CADPS
469
9311842
T
N3
0.29
0.0029930


CADPS
469
9311842
T
N5
0.37
0.0015880


CADPS
470
704356
T
G9
−0.45
0.0033380


CADPS
471
13313979
A
N2
−0.24
0.0095670


CADPS
471
13313979
A
G9
−0.26
0.0065630


CADPS
472
12636581
A
N6
−0.26
0.0081180


CADPS
472
12636581
A
N2
−0.24
0.0072280


CADPS
474
17280557
A
N6
−0.30
0.0075210


CADPS
475
17280571
T
N6
−0.31
0.0033290


CADPS
475
17280571
T
N2
−0.27
0.0050670


CADPS
476
17357618
C
G8
−0.17
0.0075370


CADPS
476
17357618
C
N6
−0.29
0.0058430


SYNPR
478
11130939
T
G7
0.26
0.0068900


PRICKLE2
479
161661
A
G7
0.21
0.0085940


PRICKLE2
479
161661
A
N1
0.30
0.0034810


PRICKLE2
480
4994608
A
P3
−0.30
0.0097530


MAGI1
481
9883580
G
G12
1.01
0.0021390


MAGI1
482
2371948
A
G8
0.50
0.0076160


MAGI1
482
2371948
A
G12
0.93
0.0022050


MAGI1
482
2371948
A
N7
0.67
0.0094890


MAGI1
483
9845819
C
G8
−0.16
0.0094880


FAM19A1
486
1491748
A
N7
0.23
0.0083170


FOXP1
487
2196356
C
G14
0.17
0.0094540


FOXP1
488
2597312
C
P7
0.17
0.0079850


FOXP1
489
2166780
T
G8
−0.17
0.0052460


GBE1
490
7622741
G
G15
0.27
0.0020670


GBE1
491
6769230
A
G15
0.26
0.0031950


GBE1
492
2307058
T
G15
0.26
0.0044090


GBE1
493
11922101
T
N5
−0.77
0.0083960


GBE1
494
7613144
T
G15
0.25
0.0064530


GBE1
496
3772899
G
G8
−0.15
0.0097220


GBE1
497
3772891
A
G8
0.20
0.0039690


GBE1
498
2680245
A
N3
−0.24
0.0035420


HTR1F
500
1027689
T
N3
0.37
0.0095000


EPHA6
501
12107680
T
G4
−0.60
0.0086820


EPHA6
502
16838196
A
G1
0.65
0.0014370


EPHA6
503
9848688
A
G1
0.55
0.0074920


DKK2
504
447372
A
G5
0.23
0.0018330


DKK2
505
379333
T
N4
−0.44
0.0094420


PAPSS1
506
2189158
T
G2
0.26
0.0026850


COL25A1
507
2305438
A
G11
−0.23
0.0050050


COL25A1
510
3096489
C
N5
0.50
0.0000011


COL25A1
511
3096490
A
N5
0.50
0.0000011


ANK2
512
13134375
C
N2
−0.23
0.0082630


ANK2
512
13134375
C
N4
−0.26
0.0066540


ANK2
513
13107082
G
N1
0.28
0.0047720


ANK2
513
13107082
G
N6
0.25
0.0081860


ANK2
513
13107082
G
G10
−0.17
0.0043110


ANK2
514
413019
C
N1
0.28
0.0058060


ANK2
514
413019
C
G10
−0.17
0.0054180


ANK2
514
413019
C
N6
0.25
0.0085470


ANK2
515
29336
T
P2
0.23
0.0092650


ANK2
515
29336
T
G1
−0.30
0.0006090


ANK2
516
29329
T
G1
−0.23
0.0066080


ANK2
518
29311
A
G8
0.18
0.0070150


ANK2
518
29311
A
P2
0.32
0.0024950


ANK2
518
29311
A
G7
0.25
0.0050810


CAMK2D
519
11946664
G
G14
−0.21
0.0025330


CAMK2D
520
10488894
C
G14
−0.19
0.0052980


NDST3
522
6820367
A
G14
−0.18
0.0064980


PRSS12
523
883686
C
P1
−0.31
0.0038050


PRSS12
523
883686
C
G2
−0.28
0.0010810


GPR103
524
11732033
A
G7
0.23
0.0085620


MAML3
526
2246759
G
G4
−0.23
0.0056290


IL15
527
17007695
C
G2
0.43
0.0078580


INPP4B
528
2667101
G
N5
0.30
0.0042020


INPP4B
529
2667108
C
G8
0.66
0.0004086


INPP4B
529
2667108
C
G13
0.67
0.0081900


INPP4B
530
336378
T
N3
0.84
0.0010640


INPP4B
530
336378
T
G11
0.97
0.0000950


INPP4B
530
336378
T
N7
0.64
0.0082390


INPP4B
531
1353603
A
G10
0.42
0.0079750


INPP4B
531
1353603
A
N3
0.67
0.0021800


INPP4B
532
336329
G
G13
0.67
0.0081900


INPP4B
532
336329
G
N3
0.82
0.0025920


INPP4B
532
336329
G
G11
0.88
0.0008613


INPP4B
532
336329
G
G8
0.66
0.0004086


INPP4B
534
2276942
A
P5
0.42
0.0059510


INPP4B
537
2627802
T
P5
−0.24
0.0055920


POU4F2
538
1979903
C
G7
−0.47
0.0040450


LDB2
539
2135442
A
N5
0.31
0.0041740


LDB2
540
12500134
A
N5
0.33
0.0076190


FSTL5
541
4501178
C
G2
0.32
0.0064200


FSTL5
541
4501178
C
G4
0.33
0.0019340


FSTL5
542
17041222
G
G7
0.25
0.0093290


FSTL5
548
7699959
A
G12
0.26
0.0066450


FSTL5
548
7699959
A
N3
0.25
0.0038910


FSTL5
548
7699959
A
G7
0.21
0.0079750


FSTL5
549
10031537
T
N3
0.25
0.0022850


FSTL5
549
10031537
T
G7
0.20
0.0084240


FSTL5
550
1994770
G
N3
−0.24
0.0037350


FSTL5
551
13101933
T
G3
−0.36
0.0099150


LDB2
552
157631
G
G8
0.29
0.0070260


LDB2
554
1990280
G
N3
−0.22
0.0062200


LDB2
554
1990280
G
G13
−0.20
0.0070020


LDB2
555
992704
T
N3
−0.26
0.0038550


LDB2
556
13110882
G
P5
0.23
0.0062780


LDB2
556
13110882
G
N3
−0.22
0.0062690


LDB2
556
13110882
G
N6
−0.33
0.0003358


PALLD
558
10009393
G
G10
−0.19
0.0031440


PALLD
559
17054309
A
G16
−0.34
0.0063510


PALLD
560
10009813
G
G10
−0.17
0.0073640


PALLD
561
2319901
G
N1
−0.27
0.0080660


PALLD
562
2712118
C
G10
0.17
0.0063330


PALLD
563
2319900
T
G10
0.16
0.0079250


PALLD
566
4425335
G
N4
−0.30
0.0059900


PALLD
569
10033898
C
G8
0.16
0.0065860


ODZ3
571
2675534
T
P7
0.25
0.0007318


ODZ3
571
2675534
T
P2
0.29
0.0065920


ODZ3
571
2675534
T
N1
0.40
0.0007424


ODZ3
572
2675532
C
P7
0.17
0.0086620


ODZ3
572
2675532
C
N1
0.28
0.0082390


ODZ3
572
2675532
C
G12
0.29
0.0030980


ODZ3
572
2675532
C
N4
0.29
0.0030560


ODZ3
573
9312304
A
G4
−0.24
0.0062270


ENPP6
574
6830766
G
G7
−0.22
0.0058610


ENPP6
579
17584049
C
G9
−0.26
0.0040030


CASP3
580
9685847
G
G9
−0.28
0.0017520


CASP3
581
2720376
C
G9
−0.27
0.0019420


SLIT2
582
1323068
A
G16
−0.25
0.0092420


SLIT2
583
621806
C
G4
−0.28
0.0008018


SLIT2
584
10516357
A
G2
0.28
0.0044990


SLIT2
585
609535
A
G4
−0.27
0.0008318


SLIT2
586
2168802
T
G2
0.36
0.0006412


SLIT2
587
9992591
C
G4
−0.28
0.0008484


PCDH7
588
12331633
C
N6
0.23
0.0099580


KIAA1239
589
4585313
C
G9
0.48
0.0068600


KIAA1239
591
2928297
A
P1
−0.28
0.0082720


TBC1D1
594
13110318
A
G5
−0.31
0.0076540


UBE2K
596
192779
A
P3
0.48
0.0010760


UBE2K
597
1003212
T
P7
0.25
0.0062240


LIMCH1
598
4343753
T
P7
0.22
0.0029980


LIMCH1
598
4343753
T
G8
0.18
0.0076530


LIMCH1
599
6447080
G
G1
0.30
0.0012160


LIMCH1
600
6447081
G
G1
0.28
0.0020740


LIMCH1
601
7671360
T
G1
0.27
0.0034520


LIMCH1
602
4610372
G
G1
0.26
0.0045040


LIMCH1
603
7683275
G
G3
0.38
0.0007506


LIMCH1
604
4861118
A
G1
0.24
0.0077590


LIMCH1
605
10026359
T
N2
−0.31
0.0053650


LIMCH1
606
6811377
A
G14
−0.17
0.0075290


LIMCH1
607
6821712
C
N7
−0.25
0.0038440


LIMCH1
608
17444879
T
P6
0.43
0.0081320


LOC389207
609
1597565
A
G7
0.24
0.0099900


NPFFR2
610
6856651
T
G8
0.19
0.0022320


NPFFR2
611
7654531
T
G8
0.19
0.0025550


NPFFR2
612
6824703
C
G8
0.18
0.0038090


NPFFR2
613
4694116
A
N2
−0.89
0.0027320


NPFFR2
614
17775309
G
P1
−0.33
0.0038050


NPFFR2
615
2365797
T
N7
−0.28
0.0011530


NPFFR2
615
2365797
T
G1
0.28
0.0036590


NPFFR2
615
2365797
T
P3
0.34
0.0041650


SCARB2
616
17001533
C
G12
−0.37
0.0078630


SHROOM3
617
10013334
T
G2
−0.34
0.0057150


SHROOM3
618
344141
C
G15
−0.24
0.0050660


SCD5
619
10014168
G
P5
−0.28
0.0087720


SCD5
620
7679857
A
N7
−0.34
0.0015940


SCD5
622
17006038
C
N7
−0.34
0.0018380


HERC3
624
3796660
A
P4
0.34
0.0090780


FAM13A1
625
12507401
C
N4
0.35
0.0025900


SLC2A9
628
1401438
T
P3
−0.39
0.0058430


PDLIM5
629
13435066
A
G15
0.25
0.0023570


PDLIM5
629
13435066
A
G10
0.15
0.0077160


SLC2A9
630
4481233
T
N5
−0.39
0.0029370


PDLIM5
631
2433325
A
G1
−0.32
0.0015350


PDLIM5
632
6812098
C
G16
0.46
0.0001203


PDLIM5
632
6812098
C
N4
0.36
0.0035100


PDLIM5
632
6812098
C
N2
0.34
0.0021210


PDLIM5
633
3805274
A
N2
0.26
0.0086370


PDLIM5
634
2452593
G
G16
0.37
0.0003595


PDLIM5
635
11735212
A
G16
0.31
0.0009057


PDLIM5
635
11735212
A
P6
0.29
0.0036940


PDLIM5
636
7689746
A
G1
−0.35
0.0044080


SLC2A9
637
13111638
T
N5
−0.36
0.0035700


SLC2A9
638
3733588
C
G10
−0.18
0.0069930


SLC2A9
638
3733588
C
G6
−0.29
0.0099750


SLC2A9
639
7669607
T
N5
−0.34
0.0046140


SLC2A9
640
9291642
C
N5
−0.38
0.0056060


SLC2A9
642
6820230
T
G5
0.20
0.0090260


SLC2A9
643
7671266
T
N5
−0.33
0.0072290


FBXL17
644
6871109
T
G16
−0.26
0.0084320


FBXL17
645
286769
T
P3
−0.36
0.0098200


FBXL17
646
11242664
G
P3
0.38
0.0089410


FBXL17
647
4957551
T
G3
−0.28
0.0095000


FBXL17
648
2416188
G
P3
0.30
0.0067080


FBXL17
649
4957554
C
P3
−0.32
0.0062560


FBXL17
650
2024528
A
P1
0.29
0.0081400


FBXL17
651
1421972
G
G3
0.35
0.0009893


PJA2
652
2963034
A
G4
−0.22
0.0063020


PJA2
653
11957188
T
P5
−0.64
0.0042340


PJA2
653
11957188
T
G9
−0.65
0.0036440


KCNN2
655
337689
G
G15
0.21
0.0084230


KCNN2
656
1072922
A
N1
0.27
0.0096620


KCNN2
657
13163662
A
N1
0.29
0.0070520


KCNN2
658
338625
T
N1
0.26
0.0093140


KCNN2
659
4435855
A
G5
−0.33
0.0009679


SEMA6A
660
254231
G
G11
0.23
0.0033470


HSD17B4
661
6897978
G
N3
−0.28
0.0075120


HSD17B4
662
246968
A
G4
−0.25
0.0016710


SNCAIP
663
10052918
A
G15
0.33
0.0012040


SNCAIP
664
7444144
G
G15
0.32
0.0018020


SNCAIP
665
17149128
G
G15
0.41
0.0009740


SNCAIP
666
17149141
A
G15
0.40
0.0015110


SNCAIP
667
304379
C
N2
−0.23
0.0056100


SNX2
668
4343835
C
P6
0.26
0.0091950


SNX2
669
12109789
G
P3
0.32
0.0041350


SNX2
671
2407403
G
G12
−0.26
0.0098520


SNX24
673
246286
T
P6
−0.32
0.0023260


SNX24
674
246266
C
P6
−0.32
0.0023640


SNX24
675
6866400
A
P7
0.18
0.0085110


ADAMTS19
676
17163231
G
G8
0.20
0.0066970


VDAC1
677
4958172
A
G8
−0.23
0.0065340


TRPC7
678
7701815
C
N1
0.27
0.0049180


TRPC7
678
7701815
C
G8
0.16
0.0031180


TRPC7
679
6596300
T
N1
−0.30
0.0019470


TRPC7
680
3777150
A
N2
0.24
0.0049440


TRPC7
680
3777150
A
N1
0.28
0.0055900


TRPC7
681
953096
C
N1
−0.30
0.0036380


DNAH5
683
6554811
G
G8
−0.16
0.0071830


DNAH5
684
7715811
T
G15
−0.31
0.0015590


DNAH5
685
1502050
G
G15
−0.31
0.0019200


DNAH5
686
10513155
A
G12
0.26
0.0082530


DNAH5
686
10513155
A
N3
0.24
0.0061840


DNAH5
686
10513155
A
G11
0.23
0.0075800


DNAH5
686
10513155
A
G15
0.28
0.0011570


DNAH5
687
7709692
C
G15
−0.33
0.0022890


DNAH5
689
1445823
C
P3
0.30
0.0060050


DNAH5
689
1445823
C
G1
0.27
0.0031900


DNAH5
690
1530498
G
G1
0.25
0.0054000


DNAH5
690
1530498
G
G14
0.16
0.0094470


DNAH5
691
13154455
G
G1
0.25
0.0072620


DNAH5
691
13154455
G
G2
0.26
0.0043680


DNAH5
692
339424
T
G1
0.28
0.0077300


GRIA1
693
1463748
A
N1
−0.31
0.0016600


GRIA1
694
7735696
C
N1
0.26
0.0083580


GRIA1
695
17518831
C
N1
0.31
0.0018810


GRIA1
696
778822
C
G4
−0.26
0.0048090


GRIA1
697
778825
A
P4
−0.24
0.0019700


GRIA1
697
778825
A
P5
−0.28
0.0025320


GRIA1
698
11953799
T
G13
−0.23
0.0077120


GRIA1
699
4424038
G
G15
−0.31
0.0019480


GRIA1
699
4424038
G
G13
−0.36
0.0001153


GRIA1
700
11167640
C
G15
−0.30
0.0025210


GRIA1
700
11167640
C
G13
−0.36
0.0001515


GRIA1
701
7708391
A
G15
−0.23
0.0085600


GRIA1
701
7708391
A
G13
−0.27
0.0010290


GRIA1
702
4958351
A
P2
0.26
0.0069350


GRIA1
703
10070447
T
G9
−0.25
0.0077290


ODZ2
704
2337017
C
P6
−0.37
0.0077140


ODZ2
704
2337017
C
G13
−0.34
0.0019890


ODZ2
704
2337017
C
G11
−0.32
0.0046270


ODZ2
704
2337017
C
G14
−0.24
0.0073700


MYO10
705
428263
A
P3
0.35
0.0019020


MYO10
706
388887
T
P3
0.33
0.0032930


ODZ2
708
1421989
G
G11
−0.28
0.0080900


ODZ2
708
1421989
G
P2
−0.31
0.0091460


ODZ2
709
13158058
T
P4
0.20
0.0081150


ODZ2
710
17069979
G
P3
−0.52
0.0078660


ODZ2
711
6868169
G
G9
0.24
0.0097920


ODZ2
711
6868169
G
G15
0.23
0.0072560


MYO10
714
11133860
G
P2
−0.31
0.0050130


BASP1
715
2956564
C
G11
−0.22
0.0086320


PLEKHG4B
716
9312845
T
N5
0.51
0.0004538


PLEKHG4B
718
6888246
T
N5
0.48
0.0010580


PLEKHG4B
719
3853521
A
N5
0.48
0.0012290


CDH10
721
7731953
T
N1
−0.43
0.0041710


CDH10
722
3822429
T
P7
−0.19
0.0027610


CDH10
722
3822429
T
N2
−0.24
0.0054650


CDH10
722
3822429
T
P6
−0.30
0.0025310


SLC45A2
723
35388
T
N2
−0.22
0.0086070


C1QTNF3
725
17583316
C
G13
−0.25
0.0031540


C1QTNF3
725
17583316
C
N5
−0.31
0.0041570


C1QTNF3
726
301506
G
P5
−0.23
0.0094750


C1QTNF3
727
6898170
G
G5
−0.19
0.0051580


C1QTNF3
727
6898170
G
G13
−0.22
0.0049640


C1QTNF3
728
9292523
C
N1
−0.32
0.0017980


C1QTNF3
728
9292523
C
G5
−0.18
0.0083330


SLC1A3
729
2113099
C
P3
0.32
0.0072760


EGFLAM
730
4869580
T
N6
0.41
0.0032350


EGFLAM
730
4869580
T
N3
0.35
0.0045490


EGFLAM
730
4869580
T
N5
0.40
0.0080270


EGFLAM
731
2589787
A
N5
0.48
0.0094900


EGFLAM
732
2886890
C
N5
0.31
0.0021350


AHRR
733
2721012
G
N2
0.31
0.0013310


AHRR
735
2672734
C
N1
−0.27
0.0092760


EXOC3
736
2561667
T
N1
−0.27
0.0099230


ITGA1
737
1820167
A
N5
−0.29
0.0044460


ITGA1
738
12520591
G
P3
0.57
0.0094040


ITGA2
740
3212576
G
N4
0.32
0.0093410


ITGA2
741
7719848
A
N4
0.26
0.0095610


PDE4D
742
2910641
A
N7
−0.29
0.0064530


PDE4D
743
258125
T
G6
0.25
0.0072690


ELOVL7
744
4541610
T
N7
0.42
0.0082400


ELOVL7
745
4482855
C
G10
−0.16
0.0060400


ELOVL7
746
6449505
C
P3
−0.42
0.0015620


ELOVL7
747
4700397
A
G10
0.17
0.0040410


ELOVL7
748
17332824
C
G10
0.19
0.0013010


TNPO1
749
153320
T
G8
0.22
0.0024000


TNPO1
749
153320
T
P3
−0.43
0.0021820


TNPO1
750
34653
T
P3
−0.41
0.0031040


TNPO1
751
266444
C
P3
−0.40
0.0047670


TNPO1
751
266444
C
G8
0.20
0.0066290


FCHO2
752
185435
G
P3
−0.42
0.0033610


CMYA5
754
6880680
C
N1
0.44
0.0078380


CMYA5
755
3828611
G
G4
0.51
0.0004989


THBS4
756
256447
C
N1
−0.33
0.0088410


THBS4
757
256444
C
N1
−0.32
0.0097460


THBS4
758
1866389
C
P4
−0.26
0.0037190


VCAN
759
11749904
C
G1
−0.24
0.0069440


VCAN
760
188703
T
G2
−0.25
0.0095740


MEF2C
761
304151
C
G16
0.27
0.0051420


MEF2C
762
17560451
C
G8
0.19
0.0096180


GPR98
763
16868901
C
G9
0.35
0.0056920


GPR98
764
16869032
A
G9
0.38
0.0094120


GPR98
765
12519770
A
P7
−0.20
0.0011720


GPR98
766
2247870
C
P7
−0.19
0.0028700


GPR98
767
3098356
C
P7
−0.18
0.0080740


SEMA5A
768
985723
A
N4
0.36
0.0078940


SEMA5A
770
11134354
A
G4
−0.28
0.0051780


SEMA5A
770
11134354
A
P6
−0.31
0.0097070


SEMA5A
771
4702625
G
G3
−0.39
0.0015410


SEMA5A
772
268481
C
G10
−0.26
0.0039070


CAST
774
11135479
C
G4
0.24
0.0053220


SLC22A16
776
2428175
A
G11
0.27
0.0070460


HS3ST5
777
12211751
A
G9
0.37
0.0049540


TRDN
781
1431284
G
P2
0.30
0.0017680


TRDN
782
17686735
G
P2
0.29
0.0024370


TRDN
783
873460
T
P2
0.26
0.0054160


TRDN
784
17085362
T
G15
0.23
0.0092100


TRDN
785
7452290
C
P6
−0.39
0.0024190


TRDN
786
9490794
T
P6
−0.36
0.0076160


TRDN
787
10499125
T
G2
−0.33
0.0002309


TRDN
788
2317707
T
G2
−0.30
0.0013080


TRDN
789
7453704
C
G11
−0.23
0.0094070


TRDN
790
2169092
T
G2
−0.22
0.0097970


NKAIN2
791
12195023
T
G16
−0.27
0.0090830


NKAIN2
792
6939050
A
G14
−0.20
0.0021930


NKAIN2
793
6910988
T
N3
−0.22
0.0066830


NKAIN2
794
1832252
G
N4
0.25
0.0075970


NKAIN2
795
1871329
C
G4
−0.30
0.0011400


NKAIN2
796
1031881
C
G15
−0.31
0.0041450


NKAIN2
796
1031881
C
P2
−0.34
0.0046210


NKAIN2
800
781487
C
P5
0.53
0.0003526


NKAIN2
800
781487
C
P3
0.52
0.0051620


NKAIN2
800
781487
C
G8
0.28
0.0031870


PHACTR1
801
6458439
C
N7
0.23
0.0046730


PHACTR1
802
9395497
G
G16
−0.34
0.0007332


PHACTR1
803
12527257
C
G16
−0.33
0.0011440


PHACTR1
804
9367368
C
G16
−0.31
0.0018350


EYA4
805
2327321
G
N5
−0.53
0.0000173


EYA4
806
9321396
G
N5
−0.49
0.0000361


EYA4
807
9375953
A
N5
−0.40
0.0014550


EYA4
808
2027210
A
N3
−0.24
0.0049670


PDE7B
809
6906788
T
N5
−0.54
0.0057170


PDE7B
810
6570049
T
G9
−0.67
0.0019710


PDE7B
811
6931583
C
G10
0.38
0.0055780


PLAGL1
812
9321951
T
P5
−0.30
0.0023360


PLAGL1
813
6916498
A
P5
−0.38
0.0003815


PLAGL1
814
9484836
A
P5
−0.38
0.0003871


UTRN
815
601873
A
N4
−0.26
0.0066050


UTRN
816
656471
C
G10
0.19
0.0032640


SYNE1
819
718527
A
G3
0.34
0.0005636


SYNE1
819
718527
A
N7
0.21
0.0091670


JARID2
820
13192234
A
P4
0.24
0.0055470


SLC22A3
821
376563
T
P2
−0.26
0.0033320


PARK2
822
2003713
A
G10
0.15
0.0090390


PARK2
823
6455738
A
G10
0.16
0.0052030


PARK2
824
9365311
C
G15
−0.23
0.0048690


PARK2
825
9355924
A
N6
−0.26
0.0075820


PARK2
825
9355924
A
G7
−0.22
0.0060100


PARK2
826
7750426
G
N5
−0.28
0.0044080


PARK2
827
9295173
G
N5
0.29
0.0036830


PARK2
828
10945823
A
G5
0.20
0.0093000


PARK2
828
10945823
A
N2
0.28
0.0049730


PARK2
830
7750033
T
N2
−0.26
0.0029560


PARK2
831
4636000
C
N2
0.23
0.0073420


PARK2
832
2155510
G
N2
0.22
0.0091110


PARK2
833
2846528
G
N4
0.27
0.0042590


PACRG
834
7740626
G
G13
0.23
0.0042910


PACRG
835
761625
A
G9
−0.30
0.0007418


PDE10A
836
525643
A
G5
0.25
0.0086370


PDE10A
837
566759
G
G11
−0.31
0.0078720


PDE10A
837
566759
G
N6
−0.35
0.0077690


PDE10A
838
484594
C
P1
0.38
0.0089850


ATXN1
839
235147
A
N4
−0.25
0.0076850


ATXN1
840
2237165
A
N1
−0.26
0.0091670


ATXN1
842
11754887
C
G10
−0.16
0.0096370


SLC17A4
843
1937131
A
G1
0.26
0.0091520


SLC17A4
844
9358890
G
P7
0.69
0.0000048


SLC17A4
844
9358890
G
G14
0.48
0.0016380


SLC17A4
844
9358890
G
G9
0.70
0.0009106


SLC17A4
846
1575535
T
G1
0.28
0.0085140


SLC17A1
847
4712976
T
P5
0.28
0.0088790


SLC17A2
849
442601
C
G5
−0.19
0.0070930


BTN3A1
850
12208788
T
P4
−0.31
0.0037000


BTN3A1
852
10946826
G
P4
−0.28
0.0045120


BTN3A1
853
10447390
G
P4
−0.27
0.0062400


BTN2A3
854
10946829
A
P4
−0.27
0.0062400


BTN3A3
855
3846847
T
P4
−0.28
0.0051800


BTNL2
856
4424066
G
P2
0.27
0.0020450


BTNL2
857
2076533
A
P2
0.27
0.0024150


BTNL2
858
2076530
G
P2
0.23
0.0074490


SLC22A23
859
17136575
G
G7
0.31
0.0025780


LRFN2
860
4714349
C
G3
−0.27
0.0089060


LRFN2
860
4714349
C
N3
0.24
0.0050500


LRFN2
861
9369205
A
N3
0.24
0.0072610


LRFN2
861
9369205
A
G12
0.28
0.0044510


LRFN2
862
1036288
A
G8
−0.17
0.0038250


LRFN2
862
1036288
A
G5
−0.20
0.0046120


LRFN2
863
403319
A
G8
−0.16
0.0052610


PPP2R5D
864
3823423
A
P1
0.56
0.0054740


KLC4
865
4714658
A
P2
0.61
0.0064770


ELOVL5
866
9370196
C
N5
0.34
0.0019440


ELOVL5
868
1429143
G
N5
0.30
0.0087170


RIMS1
870
511211
C
P3
−0.32
0.0032160


RIMS1
871
9446563
G
N5
−0.27
0.0087340


RIMS1
871
9446563
G
G3
0.28
0.0058150


RIMS1
871
9446563
G
P3
0.30
0.0077580


RIMS1
872
9293862
G
P3
−0.29
0.0092360


RIMS1
872
9293862
G
G1
−0.27
0.0024820


RIMS1
873
2496495
G
P5
−0.24
0.0100000


RIMS1
874
2496517
C
P5
−0.25
0.0086970


RIMS1
875
2463749
C
G2
−0.24
0.0082510


RIMS1
875
2463749
C
P3
−0.30
0.0075470


RIMS1
876
2254147
G
G1
−0.27
0.0031340


RIMS1
877
1015945
G
G6
−0.32
0.0020480


RIMS1
877
1015945
G
P3
−0.36
0.0019480


RIMS1
878
11754022
T
N5
−0.29
0.0093480


HTR1B
879
6296
C
G7
−0.26
0.0027960


KLHL32
880
1206084
A
G8
−0.18
0.0074420


KLHL32
881
1629523
T
G8
−0.28
0.0024920


KLHL32
882
1737646
A
G8
−0.26
0.0040920


KLHL32
883
1206149
A
G13
−0.25
0.0009723


CUX1
886
2694158
T
G14
0.22
0.0011170


CADPS2
887
2471212
G
P7
0.27
0.0004120


CADPS2
890
2251761
G
P7
0.24
0.0007916


CADPS2
891
2159827
A
P7
0.23
0.0010370


CADPS2
892
2428769
G
G9
−0.25
0.0074430


CADPS2
892
2428769
G
N7
−0.26
0.0016860


GRM8
893
1989850
C
G15
−0.24
0.0037200


GRM8
894
954661
T
G15
−0.24
0.0050950


GRM8
895
2283079
G
G15
−0.23
0.0065480


GRM8
896
2283062
G
P2
0.34
0.0004788


GRM8
897
2283064
C
G15
0.23
0.0056490


GRM8
898
6950264
G
G15
0.24
0.0061690


GRM8
898
6950264
G
G4
−0.25
0.0034660


GRM8
898
6950264
G
G7
0.24
0.0045350


GRM8
899
13240418
G
G15
−0.24
0.0037280


GRM8
900
4731330
C
G15
−0.24
0.0039610


GRM8
901
6975541
T
G15
−0.21
0.0097330


GRM8
902
1419442
T
G2
0.23
0.0089740


GRM8
903
2106183
T
G7
0.28
0.0010190


GRM8
904
916597
C
G4
0.25
0.0074300


EXOC4
905
7786489
A
G6
0.40
0.0008424


EXOC4
905
7786489
A
N4
0.33
0.0047400


EXOC4
906
7778778
G
G6
0.41
0.0006110


EXOC4
906
7778778
G
N4
0.35
0.0032260


EXOC4
907
1946303
T
N4
0.31
0.0085270


EXOC4
907
1946303
T
G6
0.40
0.0009938


EXOC4
908
11980047
A
N4
0.31
0.0091850


EXOC4
908
11980047
A
G6
0.37
0.0017280


EXOC4
909
6975109
T
G6
0.36
0.0021400


EXOC4
910
6954842
A
G11
0.24
0.0072040


EXOC4
910
6954842
A
N4
0.39
0.0002372


EXOC4
910
6954842
A
N2
0.26
0.0055730


EXOC4
911
12707127
A
G13
−0.22
0.0050630


EXOC4
912
6970436
A
G13
−0.20
0.0084370


EXOC4
913
4731992
A
G6
0.30
0.0076580


EXOC4
914
6950383
C
N4
−0.23
0.0099900


DGKI
915
16874961
C
G12
−0.28
0.0063030


DGKI
915
16874961
C
G9
−0.32
0.0009730


DGKI
916
980796
A
G9
−0.29
0.0029290


CREB3L2
917
273981
C
P6
0.27
0.0055160


CREB3L2
918
273988
A
P6
0.27
0.0058800


TBXAS1
920
2270163
G
G16
−0.28
0.0013640


TBXAS1
921
4590360
G
N4
−0.27
0.0033670


TBXAS1
922
12534299
G
N4
−0.26
0.0042550


TBXAS1
923
41723
G
N2
0.34
0.0044530


TBXAS1
923
41723
G
G7
0.29
0.0087490


TBXAS1
923
41723
G
N6
0.39
0.0025320


CNTNAP2
925
1639480
T
G12
0.26
0.0060870


CNTNAP2
925
1639480
T
P2
0.27
0.0041550


CNTNAP2
926
1639481
G
P2
0.31
0.0006389


CNTNAP2
927
986264
A
P2
0.30
0.0009067


CNTNAP2
928
6963627
T
P2
0.32
0.0005588


CNTNAP2
929
1639484
T
P2
0.29
0.0012660


CNTNAP2
930
12535047
T
G8
−0.17
0.0056230


CNTNAP2
931
11972784
C
P1
0.32
0.0098660


CNTNAP2
933
2022226
C
G16
0.25
0.0078870


CNTNAP2
934
10952682
G
P1
0.35
0.0051770


CNTNAP2
935
6953679
A
G5
0.20
0.0099500


CNTNAP2
936
700320
A
G13
0.25
0.0046060


CNTNAP2
938
6958824
A
N7
0.33
0.0026150


CNTNAP2
939
1637840
T
G3
−0.49
0.0003246


PTPRN2
940
1049325
T
N4
−0.54
0.0015840


PTPRN2
940
1049325
T
G16
−0.44
0.0085630


PTPRN2
941
4909289
A
G7
−0.25
0.0042670


PTPRN2
942
2335836
C
G6
−0.29
0.0042990


PTPRN2
943
10265417
T
P2
−0.24
0.0084970


STK31
944
12532929
T
N7
0.38
0.0002619


STK31
945
7791283
C
P2
0.28
0.0084170


SKAP2
946
3801846
A
G1
−0.32
0.0022280


SKAP2
947
13438513
C
G1
−0.29
0.0049670


SKAP2
948
13438514
A
G1
−0.29
0.0055540


SKAP2
949
17315929
T
G1
−0.27
0.0089990


SKAP2
950
10486483
A
G1
−0.27
0.0095690


CREB5
951
177486
A
G6
0.26
0.0062190


CREB5
952
2237361
C
G2
−0.28
0.0018250


CREB5
953
1544469
G
P7
−0.20
0.0048410


CREB5
954
17669844
C
G7
0.21
0.0091950


CREB5
954
17669844
C
G2
−0.30
0.0011890


CREB5
955
4722864
A
P5
0.35
0.0034100


CREB5
956
886750
A
P7
−0.19
0.0086880


CREB5
956
886750
A
P1
0.33
0.0077470


CARD11
957
3735131
C
G14
0.53
0.0047800


CHN2
958
7781003
T
G6
−0.35
0.0006594


CHN2
959
3750103
C
G5
0.43
0.0017980


SCRN1
961
13834
T
N1
−0.29
0.0056070


SCRN1
962
6976789
T
N1
−0.28
0.0070480


SCRN1
963
1465327
T
N1
−0.33
0.0038670


CRHR2
965
2190242
C
N3
0.34
0.0008023


CRHR2
965
2190242
C
G15
0.32
0.0013330


CRHR2
966
4723003
T
G1
0.46
0.0025620


FLJ22374
967
6956143
G
P4
−0.26
0.0009240


FLJ22374
967
6956143
G
P7
−0.18
0.0067100


FLJ22374
969
12690795
C
G10
0.17
0.0035590


FLJ22374
970
10243139
C
G4
0.40
0.0081700


FLJ22374
972
10229281
A
G4
0.43
0.0051690


PDE1C
973
12701142
G
G14
0.19
0.0067130


PDE1C
974
30589
G
P4
−0.33
0.0032030


PDE1C
975
30586
A
P4
−0.38
0.0017520


BMPER
976
6975236
T
N2
0.27
0.0023920


BMPER
977
7802225
G
P2
0.24
0.0071620


BMPER
978
12539069
G
N7
−0.24
0.0034980


BMPER
979
7806522
C
G8
−0.18
0.0027810


BMPER
979
7806522
C
P2
−0.26
0.0077620


BMPER
979
7806522
C
N2
−0.25
0.0060680


BMPER
979
7806522
C
P7
−0.18
0.0068380


BMPER
980
4140982
A
G8
−0.21
0.0007372


BMPER
980
4140982
A
G10
−0.17
0.0070920


BMPER
980
4140982
A
N2
−0.26
0.0051770


BMPER
981
12672492
A
G8
−0.18
0.0051760


BMPER
982
969363
C
N6
−0.27
0.0059830


VPS41
984
3801127
T
G14
−0.19
0.0031280


VPS41
985
10951578
G
G14
0.18
0.0053030


VPS41
986
859522
G
N6
0.41
0.0065930


CDC2L5
987
10272641
G
P6
0.28
0.0041930


CDC2L5
987
10272641
G
N4
0.29
0.0024270


CDC2L5
988
10277422
C
N4
0.33
0.0028310


CDC2L5
989
9639817
T
G2
0.23
0.0095010


CDC2L5
989
9639817
T
N4
0.34
0.0003946


CDC2L5
990
17171658
T
P6
0.27
0.0076810


CDC2L5
990
17171658
T
N4
0.31
0.0012590


SDK1
992
4723505
T
P6
−0.25
0.0097690


SDK1
993
1044701
A
G14
−0.17
0.0090940


IGFBP3
994
10282088
A
P5
0.38
0.0022290


IGFBP3
995
13223993
A
P5
0.33
0.0033910


IGFBP3
996
10499637
A
G7
0.28
0.0050940


ABCA13
997
6943725
A
G15
0.25
0.0019980


ABCA13
998
17132289
T
P2
−0.47
0.0086710


ABCA13
999
17729627
A
P2
−0.28
0.0093140


ABCA13
1000
17662118
A
P2
−0.31
0.0088530


ABCA13
1002
9642323
T
G8
−0.22
0.0090370


WBSCR17
1005
10950221
A
G9
0.28
0.0017610


WBSCR17
1007
10950251
A
G1
0.29
0.0012950


WBSCR17
1009
12666361
A
G1
0.24
0.0055900


WBSCR17
1010
1012127
T
G11
−0.27
0.0053600


LIMK1
1011
2855726
A
N6
0.30
0.0031480


GTF2IRD1
1014
2267834
G
P4
0.23
0.0069550


HIP1
1015
2260429
A
G6
−0.26
0.0064490


HIP1
1016
2696213
T
G6
−0.28
0.0051910


HIP1
1017
2253020
G
G6
−0.26
0.0081350


HIP1
1018
2285875
G
G7
−0.31
0.0006662


MAGI2
1019
3807797
T
G4
−0.28
0.0090180


MAGI2
1020
10238177
A
P4
−0.21
0.0097590


MAGI2
1021
38103
A
P5
0.26
0.0065150


MAGI2
1022
38111
G
G3
0.28
0.0078920


MAGI2
1023
12531031
T
G14
0.22
0.0082170


MAGI2
1024
848913
C
G13
0.31
0.0045930


MAGI2
1025
6971099
T
G13
0.28
0.0026290


MAGI2
1026
6954793
C
N2
0.34
0.0073860


MAGI2
1029
10953851
T
G4
−0.32
0.0067460


MAGI2
1030
9969364
C
G4
−0.23
0.0041770


CACNA2D1
1032
12535840
G
N6
−0.27
0.0047260


CACNA2D1
1033
258728
A
G7
−0.27
0.0025660


CACNA2D1
1033
258728
A
N6
−0.29
0.0069820


CACNA2D1
1034
2059037
C
G2
0.35
0.0049850


CACNA2D1
1034
2059037
C
G7
−0.41
0.0002072


CACNA2D1
1034
2059037
C
N3
−0.34
0.0044630


CACNA2D1
1034
2059037
C
N6
−0.40
0.0028950


CACNA2D1
1034
2059037
C
G10
−0.22
0.0082140


PCLO
1035
10954689
T
G7
0.22
0.0039160


PCLO
1041
9656532
A
N5
−0.29
0.0072800


PCLO
1042
2715148
A
G13
0.21
0.0059090


PCLO
1042
2715148
A
G7
0.21
0.0067400


PCLO
1043
2522833
C
G13
0.22
0.0050570


PCLO
1043
2522833
C
G7
0.22
0.0041040


PCLO
1044
2371214
C
G13
0.23
0.0029330


PCLO
1045
2522843
A
G13
0.22
0.0054520


PCLO
1045
2522843
A
G7
0.21
0.0059480


PCLO
1047
1986742
G
G13
−0.20
0.0072170


PCLO
1048
17282763
C
N5
−0.27
0.0079140


PCLO
1049
12539066
T
P3
−0.32
0.0097250


PCLO
1050
12531615
C
G6
−0.29
0.0016810


PCLO
1051
17157155
T
G6
−0.28
0.0027380


PCLO
1053
16887406
G
G6
−0.28
0.0028090


PCLO
1054
4129230
T
P1
0.36
0.0018800


PCLO
1054
4129230
T
N7
0.28
0.0009215


PCLO
1054
4129230
T
P6
0.32
0.0026010


PCLO
1054
4129230
T
G5
0.20
0.0077110


PCLO
1054
4129230
T
G9
0.30
0.0018250


SEMA3A
1058
11978893
G
N5
−0.35
0.0029920


SEMA3E
1059
169992
C
N4
−0.27
0.0063570


SEMA3E
1060
3801562
C
G1
0.24
0.0080620


SEMA3E
1061
1972459
C
G13
−0.23
0.0066110


SEMA3A
1063
6965990
A
P3
0.30
0.0071050


SEMA3A
1063
6965990
A
N4
0.27
0.0045080


SEMA3A
1063
6965990
A
N2
0.23
0.0062760


SEMA3A
1064
11976072
T
P3
0.29
0.0099500


SEMA3A
1064
11976072
T
N4
0.26
0.0054950


SEMA3A
1065
13228082
G
N2
0.22
0.0090980


SEMA3A
1065
13228082
G
N4
0.25
0.0076380


NXPH1
1071
970526
G
G11
0.24
0.0085230


ABCB4
1072
2097937
G
N3
−0.29
0.0079540


ABCB4
1073
31662
A
G4
−0.39
0.0022740


ADAM22
1075
17255978
A
G1
0.69
0.0015120


ADAM22
1076
1688886
G
G16
0.25
0.0094840


ADAM22
1076
1688886
G
P6
0.46
0.0000073


ADAM22
1078
2282949
C
P6
0.42
0.0000409


ADAM22
1078
2282949
C
P1
0.41
0.0002684


ADAM22
1079
6951172
T
P5
0.30
0.0013760


ADAM22
1079
6951172
T
G9
0.27
0.0041660


ADAM22
1079
6951172
T
P1
0.33
0.0039290


ADAM22
1080
9632709
C
P5
0.28
0.0021550


ADAM22
1080
9632709
C
G9
0.26
0.0048850


ADAM22
1080
9632709
C
P1
0.33
0.0042990


ADAM22
1081
2299199
G
P1
0.32
0.0045500


ADAM22
1081
2299199
G
G9
0.24
0.0091970


ADAM22
1081
2299199
G
P5
0.26
0.0045860


ADAM22
1082
10268574
T
G10
0.20
0.0099450


ADAM22
1083
4140919
G
N7
0.32
0.0035660


ADAM22
1085
17150307
C
G4
0.38
0.0024420


NXPH1
1086
6962955
A
G1
−0.24
0.0085140


NXPH1
1086
6962955
A
G13
−0.25
0.0018330


PPP1R9A
1087
854535
C
G5
0.23
0.0009944


PPP1R9A
1088
3917551
T
G8
−0.31
0.0075500


PON1
1089
2158155
A
G8
−0.30
0.0093400


PON1
1091
705378
T
G1
0.24
0.0083890


DYNC1I1
1092
319329
G
N5
0.30
0.0022040


GRHL2
1094
536022
G
G11
0.40
0.0044060


GRHL2
1095
608337
C
G11
0.39
0.0086210


GRHL2
1096
13275653
C
G11
−0.24
0.0048940


GRHL2
1096
13275653
C
N3
−0.27
0.0026210


GRHL2
1097
4734037
C
G11
−0.27
0.0090110


NCALD
1098
1131862
G
G12
−0.32
0.0048430


NCALD
1098
1131862
G
N3
−0.30
0.0032540


NCALD
1098
1131862
G
G11
−0.33
0.0006944


NCALD
1099
16868201
A
G11
−0.30
0.0053330


NCALD
1100
2387620
G
G5
−0.20
0.0075570


NCALD
1101
2226401
C
G13
−0.27
0.0038330


NCALD
1101
2226401
C
G5
−0.23
0.0049780


ZFPM2
1102
16873003
C
G16
0.29
0.0070860


ZFPM2
1104
1481026
T
G16
0.29
0.0074670


ZFPM2
1106
13280496
C
P5
0.29
0.0024180


ZFPM2
1107
7003141
C
P6
0.36
0.0010060


ZFPM2
1107
7003141
C
P1
0.36
0.0028050


ZFPM2
1107
7003141
C
G9
0.28
0.0040850


ZFPM2
1109
12546300
G
G10
0.16
0.0073250


CSMD3
1115
7012235
C
G8
0.53
0.0004453


CSMD3
1116
1382469
C
P7
0.19
0.0095280


CSMD3
1117
720406
C
P7
0.19
0.0098290


SAMD12
1120
7825963
A
P5
0.30
0.0010170


SAMD12
1120
7825963
A
P1
0.35
0.0025560


SAMD12
1121
4876840
A
P5
0.29
0.0017730


SAMD12
1121
4876840
A
P1
0.33
0.0039540


SAMD12
1122
7830423
C
P5
0.23
0.0084430


FBXO32
1124
12548263
T
P5
−0.32
0.0020230


FER1L6
1127
7838453
A
G15
−0.24
0.0024640


FER1L6
1127
7838453
A
N2
−0.22
0.0081370


FER1L6
1127
7838453
A
G16
−0.29
0.0011000


FER1L6
1127
7838453
A
G9
−0.22
0.0096400


FER1L6
1128
4537289
T
G14
−0.26
0.0016260


FER1L6
1129
4478556
T
G14
−0.24
0.0023000


FER1L6
1130
13279726
G
G14
−0.21
0.0046370


FER1L6
1131
4242352
C
G14
−0.19
0.0089120


FER1L6
1132
6981430
G
G12
0.30
0.0023030


FER1L6
1133
7819868
G
P1
0.31
0.0043000


FER1L6
1133
7819868
G
P6
0.27
0.0052110


MTSS1
1137
6470252
C
P6
−0.31
0.0027990


MTSS1
1137
6470252
C
G1
−0.24
0.0097950


MTSS1
1138
4871503
C
P6
0.38
0.0054270


DLC1
1139
2203838
C
N3
−0.31
0.0056340


DLC1
1139
2203838
C
N4
−0.36
0.0038230


DDEF1
1140
2670882
G
N5
−0.40
0.0084760


ADCY8
1141
7016933
A
G5
0.22
0.0014840


ADCY8
1142
7464362
G
G1
0.24
0.0073450


ADCY8
1143
11781997
A
G5
0.23
0.0004697


ADCY8
1143
11781997
A
G2
0.24
0.0043980


ADCY8
1143
11781997
A
N7
0.22
0.0043180


KCNQ3
1145
977939
A
P3
0.31
0.0041890


ST3GAL1
1147
2978015
T
G7
−0.24
0.0026210


ST3GAL1
1148
2945779
A
G7
−0.21
0.0070080


ST3GAL1
1149
17722401
A
G1
−0.25
0.0097290


COL22A1
1150
4475485
T
G2
−0.40
0.0061060


COL22A1
1152
13279213
A
P2
0.28
0.0068430


SGCZ
1153
1382147
A
G2
−0.41
0.0013960


SGCZ
1154
11990657
T
G5
0.22
0.0048200


SGCZ
1154
11990657
T
G4
0.27
0.0029710


SGCZ
1155
13261120
C
P3
0.38
0.0009172


SGCZ
1156
4427170
T
P3
0.29
0.0093140


SGCZ
1156
4427170
T
G6
0.29
0.0029130


SLC7A2
1157
2588222
A
N4
0.27
0.0034900


SLC7A2
1158
2588223
T
P6
0.29
0.0050040


PSD3
1160
1386688
G
G4
−0.31
0.0038880


PSD3
1161
7837572
T
G4
−0.32
0.0043610


PSD3
1162
13272436
G
G14
−0.19
0.0070860


PSD3
1163
11782622
C
G4
0.26
0.0038310


PSD3
1164
7007413
T
G4
0.26
0.0012340


PSD3
1165
1492289
C
G14
−0.17
0.0057410


PSD3
1166
4921968
A
P7
−0.17
0.0077580


PSD3
1166
4921968
A
G14
−0.20
0.0019750


PSD3
1167
6998537
G
G9
0.42
0.0061480


PSD3
1168
11778310
G
P7
−0.22
0.0019470


PSD3
1169
1506894
C
G6
−0.47
0.0071880


ATP6V1B2
1170
952148
T
G15
−0.40
0.0023880


GFRA2
1171
4077793
C
P3
−0.38
0.0018170


PEBP4
1172
4872539
C
G9
0.25
0.0090260


SLC25A37
1174
10503726
C
G12
−0.36
0.0014890


SLC25A37
1175
11778179
T
G12
−0.46
0.0004472


CSMD1
1176
622765
A
G4
0.29
0.0064730


CSMD1
1177
7845140
G
P7
0.37
0.0081810


CSMD1
1178
4875250
G
G1
−0.32
0.0061320


CSMD1
1179
4487803
G
G3
0.30
0.0036250


CSMD1
1181
17065959
C
N3
−0.30
0.0088110


CSMD1
1183
12543159
T
G3
0.27
0.0075310


CSMD1
1184
2938236
T
P6
0.58
0.0047560


CSMD1
1184
2938236
T
G16
0.53
0.0053610


UNC5D
1186
2589344
T
N1
−0.34
0.0073910


UNC5D
1186
2589344
T
N2
−0.29
0.0080970


UNC5D
1186
2589344
T
N4
−0.35
0.0030110


UNC5D
1187
7826624
T
N3
−0.26
0.0049960


SFRP1
1188
4736959
C
P2
0.25
0.0089270


SNTG1
1193
318851
T
G7
−0.49
0.0038520


SNTG1
1194
10504093
G
G7
−0.47
0.0052210


SNTG1
1195
10957739
G
G7
−0.27
0.0052140


SNTG1
1196
2106156
A
G11
−0.27
0.0043320


MCPH1
1197
1530408
C
G15
0.43
0.0000761


MCPH1
1197
1530408
C
P4
0.33
0.0007420


MCPH1
1198
2916750
C
P4
0.30
0.0023730


MCPH1
1199
1054073
T
G15
0.32
0.0021200


MCPH1
1200
1868551
T
P4
0.29
0.0036450


MCPH1
1201
2922818
T
P4
0.29
0.0040630


MCPH1
1202
2920660
A
G15
0.34
0.0024740


MCPH1
1203
2916741
G
P4
0.29
0.0044610


MCPH1
1203
2916741
G
G15
0.33
0.0029680


MCPH1
1204
2440399
C
P4
0.26
0.0056170


MCPH1
1205
2442492
T
G15
0.28
0.0070860


MCPH1
1205
2442492
T
P4
0.26
0.0057890


NKAIN3
1206
4257998
A
G8
0.22
0.0082730


MCPH1
1208
3020213
T
G15
0.26
0.0026600


MCPH1
1208
3020213
T
P2
0.29
0.0028620


MCPH1
1209
2515435
G
G15
0.25
0.0042120


MCPH1
1209
2515435
G
P2
0.27
0.0041080


NKAIN3
1210
1480194
C
G12
0.36
0.0034440


NKAIN3
1211
1383154
A
G7
−0.26
0.0084630


NKAIN3
1212
16929903
G
N1
−0.32
0.0036450


NKAIN3
1213
11989852
A
N3
0.46
0.0043540


NKAIN3
1214
17279355
G
N3
0.39
0.0086890


NKAIN3
1214
17279355
G
P7
0.31
0.0058880


MCPH1
1215
11998083
T
G3
−0.26
0.0082850


DEPDC2
1217
6988386
C
P3
0.47
0.0090370


DEPDC2
1218
2053140
A
G8
−0.16
0.0065190


DEPDC2
1219
6990381
T
P3
0.29
0.0092950


DEPDC2
1219
6990381
T
N5
0.31
0.0020080


DEPDC2
1219
6990381
T
N1
0.27
0.0055850


DEPDC2
1220
2380437
T
N5
0.31
0.0025060


DEPDC2
1221
16934215
A
G6
0.44
0.0024850


DEPDC2
1222
3793381
A
G6
0.41
0.0041560


DEPDC2
1223
7821308
A
P7
−0.19
0.0057980


DEPDC2
1224
10808759
C
P7
−0.18
0.0057040


KCNB2
1225
349358
G
N5
−0.37
0.0061060


KCNB2
1226
349355
T
N5
−0.37
0.0066520


KCNB2
1228
2256431
A
G7
−0.23
0.0049940


KCNB2
1229
1972888
C
G7
−0.25
0.0022710


KCNB2
1230
2196904
C
G7
−0.22
0.0073420


MMP16
1233
278887
C
P7
−0.19
0.0068410


MMP16
1234
2664370
C
P7
−0.18
0.0071640


MMP16
1235
2616493
C
G5
0.23
0.0038820


MMP16
1235
2616493
C
N1
0.31
0.0063300


MMP16
1236
6994019
T
N7
−0.24
0.0089210


MMP16
1239
4961087
C
N3
−0.29
0.0015200


MMP16
1240
10504845
T
N3
−0.28
0.0062940


MMP16
1241
4548227
A
N3
−0.28
0.0019820


GABBR2
1244
2778913
T
G4
−0.36
0.0043020


GABBR2
1244
2778913
T
G15
−0.37
0.0040610


GABBR2
1245
1930139
G
G12
−0.29
0.0092010


RP11-35N6.1
1246
10989207
T
G15
0.22
0.0085370


GRIN3A
1247
7023041
A
G12
0.41
0.0004123


GRIN3A
1248
10989589
A
N5
−0.28
0.0069490


GRIN3A
1249
4615635
T
N5
−0.32
0.0018750


FKTN
1250
2768294
C
P5
−0.28
0.0025840


FKTN
1251
885954
C
G14
−0.18
0.0064680


FKTN
1252
635712
C
G2
0.30
0.0009908


SVEP1
1253
963143
A
G13
−0.21
0.0069400


SVEP1
1254
10759422
C
P4
−0.27
0.0026430


SVEP1
1255
7875389
C
P4
−0.23
0.0019450


CDK5RAP2
1256
2282168
C
G11
−0.27
0.0083170


CDK5RAP2
1257
12238807
C
P5
−0.42
0.0089250


CDK5RAP2
1258
10818467
C
P5
−0.50
0.0082280


CDK5RAP2
1259
4837782
T
P5
−0.51
0.0083630


DAB2IP
1261
10985431
T
G14
0.27
0.0045700


RALGPS1
1262
561041
C
G14
−0.20
0.0016520


RALGPS1
1263
665249
G
G14
−0.19
0.0022890


RALGPS1
1264
1123684
T
G14
0.22
0.0013510


RALGPS1
1265
10760473
G
G14
−0.19
0.0024290


RALGPS1
1266
13298677
G
G14
−0.21
0.0046150


SLC25A25
1267
4837235
A
G12
0.37
0.0082150


SLC25A25
1267
4837235
A
G2
−0.36
0.0060960


SLC25A25
1268
9695803
C
N3
0.34
0.0042130


SLC25A25
1268
9695803
C
G12
0.35
0.0087230


FREQ
1269
12003792
A
G6
0.28
0.0086910


EXOSC2
1270
10901275
C
P2
0.27
0.0074950


ABL1
1271
6597642
A
P2
−0.42
0.0018260


ABL1
1272
1800609
C
P2
−0.38
0.0044690


ABL1
1274
3824400
A
P2
−0.37
0.0056390


VAV2
1277
2519102
G
G2
−0.27
0.0079990


OLFM1
1279
542172
A
G15
0.39
0.0096740


OLFM1
1279
542172
A
G11
0.61
0.0000435


OLFM1
1279
542172
A
G13
0.39
0.0062000


INPP5E
1280
3812591
C
N6
0.32
0.0021870


NOTCH1
1281
3013304
C
G2
−0.26
0.0052680


CACNA1B
1282
2278975
C
G10
1.19
0.0023780


CACNA1B
1283
7860423
A
G10
0.20
0.0097920


ASAH3L
1284
12335928
A
G10
−0.17
0.0082630


KIAA1797
1285
12338810
T
G6
−0.34
0.0076580


KIAA1797
1285
12338810
T
G3
−0.37
0.0047610


KIAA1797
1286
12336110
A
G3
−0.37
0.0060610


KIAA1797
1286
12336110
A
G6
−0.34
0.0085570


KIAA1797
1287
7021708
G
G1
0.26
0.0049190


KIAA1797
1288
16938162
C
G7
0.23
0.0041240


KIAA1797
1288
16938162
C
N1
0.37
0.0003204


KIAA1797
1289
10511687
G
N1
0.35
0.0005773


KIAA1797
1289
10511687
G
G13
0.26
0.0013150


KIAA1797
1289
10511687
G
N3
0.28
0.0010380


KIAA1797
1289
10511687
G
G11
0.22
0.0082980


KIAA1797
1289
10511687
G
N6
0.31
0.0013040


KIAA1797
1289
10511687
G
G7
0.23
0.0044350


KIAA1797
1290
10964719
T
G2
−0.29
0.0014030


KIAA1797
1293
6475491
G
G2
−0.29
0.0020350


KIAA1797
1294
10511693
G
N5
0.30
0.0088380


KIAA1797
1294
10511693
G
G15
0.29
0.0020850


KIAA1797
1295
4579612
C
G2
0.29
0.0023610


KIAA1797
1297
7025851
G
G2
−0.25
0.0060460


KIAA1797
1298
7030990
G
P4
0.24
0.0062690


KIAA1797
1299
4977881
A
G15
0.28
0.0021590


KIAA1797
1300
4468020
T
G15
0.26
0.0051060


SMARCA2
1301
6475520
G
G6
0.41
0.0067800


SMARCA2
1302
6475522
A
G6
0.41
0.0089820


SMARCA2
1303
3793499
G
G6
0.55
0.0001478


SMARCA2
1304
10116703
A
N5
0.27
0.0066610


IFT74
1305
17694549
C
G13
0.44
0.0068240


IFT74
1305
17694549
C
G14
0.42
0.0018630


TEK
1309
12339867
C
G11
−0.31
0.0058700


SLC1A1
1310
9886720
T
N5
0.33
0.0043410


SLC1A1
1311
4742008
A
N5
0.30
0.0065550


PIP5K1B
1314
2152647
T
N3
0.23
0.0075090


PIP5K1B
1314
2152647
T
N6
0.28
0.0026870


PIP5K1B
1315
1414949
T
N3
−0.22
0.0082530


PIP5K1B
1315
1414949
T
N6
−0.27
0.0046400


PIP5K1B
1316
11144133
T
N6
0.27
0.0048250


APBA1
1318
10481751
T
G13
0.23
0.0094210


TRPM3
1319
1932701
C
N1
−0.42
0.0045100


TRPM3
1320
2275242
G
P1
0.29
0.0085320


TRPM3
1320
2275242
G
P5
0.25
0.0067130


TRPM3
1321
6560161
G
N5
−0.30
0.0046320


TRPM3
1323
2993010
A
N5
−0.34
0.0011450


TRPM3
1323
2993010
A
N2
−0.23
0.0090390


TMC1
1324
6560297
T
N5
−0.29
0.0061080


TMC1
1325
12347235
A
N5
−0.36
0.0028060


TMC1
1326
2501914
T
N5
0.30
0.0031990


PCSK5
1328
1029035
C
N6
−0.28
0.0014380


PCSK5
1328
1029035
C
N3
−0.21
0.0068430


PCSK5
1329
914367
T
N7
−0.24
0.0049840


GNAQ
1330
1030828
A
G13
−0.23
0.0056920


GNAQ
1331
2378100
G
G7
−0.24
0.0016740


GNAQ
1332
10870048
T
N3
−0.27
0.0093900


PTPRD
1333
1500326
T
P5
−0.25
0.0072700


PTPRD
1334
7036240
A
P5
−0.26
0.0044690


PTPRD
1334
7036240
A
N3
0.24
0.0057980


NTRK2
1335
1187321
A
N5
0.38
0.0065870


NTRK2
1335
1187321
A
G8
0.24
0.0023610


DAPK1
1338
1927976
G
G8
−0.19
0.0010070


DAPK1
1339
1927975
G
G8
0.14
0.0098350


DAPK1
1340
1056719
G
G13
0.22
0.0055050


SORCS3
1341
10884026
G
P5
−0.31
0.0061140


SORCS3
1342
10884052
C
P6
0.31
0.0020190


SOPCS3
1343
2491377
T
P6
−0.30
0.0098710


SORCS3
1344
2451498
C
P6
−0.29
0.0098930


SORCS3
1346
1961640
C
P6
0.27
0.0056240


SORCS3
1347
790663
T
G12
−0.26
0.0060990


SORCS3
1348
2696864
A
G12
−0.34
0.0008217


SORCS3
1349
10160134
A
G12
0.30
0.0020400


SORCS3
1350
697189
C
G12
0.29
0.0022860


SORCS3
1351
697190
C
G12
0.27
0.0069240


SORCS3
1352
7072425
T
G11
0.38
0.0061330


SORCS3
1352
7072425
T
G13
0.37
0.0055370


CUGBP2
1353
3243
C
G7
0.23
0.0084640


VTI1A
1354
10509963
A
P3
−0.31
0.0093380


VTI1A
1355
10885352
T
P3
−0.31
0.0099750


VTI1A
1355
10885352
T
G16
−0.26
0.0098450


VTI1A
1356
11196051
G
G3
0.29
0.0097550


VTI1A
1357
7907012
G
N5
0.33
0.0023160


VTI1A
1358
7907540
A
N5
0.30
0.0052170


VTI1A
1359
7068695
C
N1
0.26
0.0082790


VTI1A
1360
4145776
G
N1
0.29
0.0067390


HSPA12A
1361
3010460
C
G8
0.17
0.0038730


HSPA12A
1362
735412
G
G8
0.25
0.0097560


ATE1
1363
7086628
C
P6
−0.31
0.0010380


ATE1
1363
7086628
C
N3
−0.21
0.0087970


ATE1
1364
1219505
T
P1
−0.28
0.0060540


ATE1
1364
1219505
T
N3
−0.21
0.0080360


ATE1
1365
1693682
A
P6
−0.32
0.0015320


ATE1
1365
1693682
A
N3
−0.25
0.0029740


ATE1
1366
10732824
A
G13
−0.38
0.0047450


ATE1
1366
10732824
A
N7
−0.40
0.0036090


ATE1
1367
2420970
T
P1
0.37
0.0004130


CTBP2
1370
4962718
C
N5
0.29
0.0089980


ARMC3
1371
17440393
A
G1
0.33
0.0020190


ARMC3
1371
17440393
A
P1
0.47
0.0004260


ARMC3
1372
11013210
T
G1
0.29
0.0074760


ARMC3
1373
7084413
C
G6
0.30
0.0044130


ARMC3
1374
10828389
T
G1
0.28
0.0055940


ARMC3
1374
10828389
T
G6
0.30
0.0053160


ARMC3
1375
10828395
A
G1
0.35
0.0015950


ARMC3
1376
7898656
A
G1
0.34
0.0039890


ARMC3
1377
1382579
G
P2
0.67
0.0014970


ARHGAP21
1378
7897303
A
G1
−0.30
0.0055920


MYO3A
1379
7084614
T
G4
−0.23
0.0096120


PITRM1
1381
2306310
C
P7
−0.23
0.0089410


PITRM1
1382
9129
C
P7
−0.23
0.0089410


PITRM1
1383
3740607
A
G13
0.23
0.0027190


PITRM1
1385
7092621
A
G13
0.26
0.0029930


SLC16A9
1386
6481469
A
G4
0.56
0.0003589


SLC16A9
1387
3763747
C
N6
−0.30
0.0062020


SLC16A9
1387
3763747
C
N1
−0.31
0.0078040


PRKCQ
1391
661891
T
N6
0.35
0.0001849


PRKCQ
1392
9423765
A
N6
0.27
0.0051980


CDH23
1393
17635709
T
G3
0.33
0.0067420


CDH23
1394
10999947
A
G10
−0.20
0.0042540


CDH23
1395
7094357
A
N3
0.24
0.0096950


KCNMA1
1396
2288840
G
P7
0.19
0.0041030


KCNMA1
1397
10740460
A
G6
−0.28
0.0095040


KCNMA1
1398
4639876
T
G6
−0.27
0.0061470


KCNMA1
1399
7067873
C
P4
0.22
0.0052870


KCNMA1
1399
7067873
C
P7
0.18
0.0096960


KCNMA1
1400
1907729
T
G6
−0.40
0.0046610


KCNMA1
1401
7897566
C
N4
0.39
0.0000659


KCNMA1
1401
7897566
C
N6
0.29
0.0025480


KCNMA1
1401
7897566
C
N7
0.21
0.0083090


KCNMA1
1401
7897566
C
G14
0.18
0.0049070


KCNMA1
1401
7897566
C
G15
0.23
0.0059900


KCNMA1
1401
7897566
C
G7
0.24
0.0024660


KCNMA1
1401
7897566
C
G13
0.24
0.0024780


KCNMA1
1401
7897566
C
G16
0.25
0.0068400


KCNMA1
1401
7897566
C
G11
0.30
0.0003752


KCNMA1
1401
7897566
C
P2
0.34
0.0002477


KCNMA1
1402
10824520
T
G12
−0.29
0.0019630


KCNMA1
1403
11002121
A
G12
−0.29
0.0025370


KCNMA1
1404
11002139
A
G12
−0.30
0.0025480


KCNMA1
1405
1371457
A
G12
−0.28
0.0033410


KCNMA1
1406
10824547
T
G12
0.53
0.0005635


KCNMA1
1406
10824547
T
N3
0.43
0.0015520


KCNMA1
1407
2719986
T
P6
−0.30
0.0020550


NRG3
1409
10884538
T
G5
−0.22
0.0071700


NRG3
1412
495978
A
G15
0.26
0.0036690


SORBS1
1413
3814150
G
N3
−0.27
0.0021460


SORBS1
1414
11188298
C
G13
0.25
0.0020830


SORBS1
1415
11188299
C
G6
−0.64
0.0065380


SORBS1
1416
4918921
G
N3
−0.24
0.0053900


SORBS1
1416
4918921
G
G13
−0.23
0.0051310


SORBS1
1417
1536556
A
G13
−0.23
0.0034250


SORBS1
1418
540746
T
G16
−0.25
0.0045690


ELMOD1
1419
683266
A
P3
0.32
0.0073560


GALNTL4
1420
10831565
A
G10
0.18
0.0018020


GALNTL4
1420
10831565
A
G16
−0.23
0.0098840


GALNTL4
1421
7122801
T
G16
−0.27
0.0065250


MICAL2
1422
10765929
T
P1
−0.51
0.0000098


MICAL2
1423
2010463
A
P1
−0.43
0.0000911


MICAL2
1424
11822285
T
P1
−0.39
0.0002196


MICAL2
1425
7117024
G
P1
−0.44
0.0002173


MICAL2
1426
17477949
T
G13
−0.23
0.0034800


MICAL2
1427
2270511
G
P1
0.41
0.0082260


OPCML
1429
3016384
A
G8
0.15
0.0076470


ARNTL
1430
7107711
C
N7
−0.26
0.0094590


OPCML
1433
7936263
G
G15
0.27
0.0051090


OPCML
1433
7936263
G
P2
0.28
0.0070530


OPCML
1434
7108751
T
P2
0.29
0.0080810


SPON1
1435
1507527
C
G6
0.29
0.0061720


SPON1
1436
2049723
C
G6
0.34
0.0017820


SPON1
1437
1528668
C
N3
0.25
0.0048540


SPON1
1438
7112850
A
N3
0.24
0.0060470


SPON1
1439
10766134
G
N3
0.23
0.0061030


SPON1
1440
10832170
T
N3
0.22
0.0087010


SPON1
1440
10832170
T
N2
0.25
0.0033110


SPON1
1440
10832170
T
N4
0.25
0.0081060


SPON1
1441
1406356
A
N2
0.27
0.0018150


SPON1
1441
1406356
A
N4
0.26
0.0065680


SPON1
1442
7116296
T
N2
−0.25
0.0045770


SPON1
1443
11023088
T
N2
−0.24
0.0054460


SPON1
1444
4757244
A
N5
−0.35
0.0021520


INSC
1445
1792571
A
N1
0.33
0.0041810


INSC
1445
1792571
A
N4
0.30
0.0058370


INSC
1445
1792571
A
G7
0.24
0.0063900


INSC
1445
1792571
A
N2
0.37
0.0001496


KCNA4
1446
11030913
C
G9
0.36
0.0020210


KCNA4
1447
10835607
A
G9
0.34
0.0027960


STIM1
1449
10835249
G
P3
−0.36
0.0009898


STIM1
1450
2923944
G
G15
0.22
0.0098320


81.99 mb
1454
2186693
T
G5
−0.20
0.0074750


DLG2
1455
11233564
A
P4
−0.49
0.0044530


DLG2
1456
11233565
C
P2
−0.67
0.0013580


DLG2
1456
11233565
C
N7
−0.52
0.0047130


DLG2
1456
11233565
C
P4
−0.44
0.0097570


DLG2
1457
6592113
A
N7
−0.26
0.0013040


DLG2
1457
6592113
A
G11
−0.23
0.0046300


DLG2
1460
558211
G
G6
0.26
0.0080380


DLG2
1461
635823
G
G2
0.26
0.0048390


DLG2
1462
2514147
G
G16
0.41
0.0067680


DLG2
1462
2514147
G
G7
0.36
0.0051240


DLG2
1463
10898192
G
N3
0.38
0.0049450


DLG2
1463
10898192
G
G7
0.33
0.0076490


DLG2
1464
7928752
C
N3
0.38
0.0089480


DLG2
1465
1945832
T
P4
−0.37
0.0057640


DLG2
1466
6592202
C
G9
−0.25
0.0055200


DLG2
1466
6592202
C
N7
−0.21
0.0085500


DLG2
1467
4451754
A
G9
−0.24
0.0093620


DLG2
1470
11234221
A
G9
−0.23
0.0095600


DLG2
1470
11234221
A
G11
−0.21
0.0093050


DLG2
1470
11234221
A
N7
−0.22
0.0065310


DLG2
1470
11234221
A
P6
−0.29
0.0034420


DLG2
1471
11234222
A
N7
−0.21
0.0081670


DLG2
1471
11234222
A
P6
−0.29
0.0038850


DLG2
1471
11234222
A
N2
−0.25
0.0036900


DLG2
1473
11234225
T
P3
−0.43
0.0001278


DLG2
1473
11234225
T
G11
−0.21
0.0090030


DLG2
1474
6592211
A
P3
−0.44
0.0000786


DLG2
1475
7101454
C
P3
−0.41
0.0002288


DLG2
1476
582652
A
N2
−0.34
0.0074060


CHST11
1477
1795849
G
P4
−0.25
0.0037010


CHST11
1478
2055861
C
P6
−0.25
0.0091200


CHST11
1479
1097245
G
G9
0.24
0.0099240


PLA2G1B
1481
2701632
G
P6
−0.38
0.0001323


LOC729025
1482
1913253
T
G1
0.24
0.0054970


LOC729025
1483
1799491
T
G1
−0.24
0.0067540


PIK3C2G
1484
10770343
C
P6
0.28
0.0072800


PIK3C2G
1485
9300118
G
P6
0.28
0.0034110


PIK3C2G
1486
11044057
A
G6
0.45
0.0059650


PIK3C2G
1487
11044165
C
G4
0.30
0.0003435


PIK3C2G
1487
11044165
C
G7
−0.21
0.0090200


PIK3C2G
1488
10841059
A
G10
−0.17
0.0058320


ITPR2
1489
10842708
G
G2
−0.27
0.0093630


TMEM16B
1491
9645764
C
N1
−0.31
0.0077220


LRP1
1492
1799986
T
N5
−0.40
0.0047260


TMEM16B
1493
10774369
T
G12
0.28
0.0036530


TMEM16B
1494
2277401
C
G8
0.15
0.0088880


TMEM16B
1494
2277401
C
G10
0.17
0.0041830


TMEM16B
1495
2159952
A
G6
0.34
0.0005129


TMEM16B
1496
10849338
G
G6
0.36
0.0012240


TMEM16B
1497
3782659
T
G6
0.25
0.0093090


TMEM16B
1498
11063875
T
G1
0.26
0.0063660


CNOT2
1500
1595410
C
G1
0.26
0.0040450


CNOT2
1501
3817487
A
N2
0.23
0.0070250


KCNC2
1502
10879888
G
N1
0.35
0.0019800


KCNC2
1503
10735985
G
N5
0.35
0.0008785


KCNC2
1503
10735985
G
N6
0.28
0.0047040


KCNC2
1504
2471664
C
N5
0.34
0.0063280


KCNC2
1504
2471664
C
N7
0.26
0.0068700


KCNC2
1504
2471664
C
G15
0.32
0.0017050


KCNC2
1504
2471664
C
N3
0.29
0.0045910


KCNC2
1504
2471664
C
G11
0.28
0.0042050


KCNC2
1504
2471664
C
N6
0.37
0.0012390


KCNC2
1504
2471664
C
N1
0.36
0.0028950


KCNC2
1505
4290307
T
G11
0.29
0.0067140


NAV3
1506
11106732
G
N4
0.29
0.0042190


NAV3
1507
939458
G
N4
0.27
0.0059560


NAV3
1508
1677923
G
N3
0.46
0.0015940


NAV3
1509
1677914
G
N3
0.40
0.0057700


NAV3
1510
10859620
G
G5
−0.19
0.0062940


NAV3
1511
1479027
G
N3
0.36
0.0090810


NAV3
1511
1479027
G
G4
0.34
0.0087190


NAV3
1512
11107419
T
G2
−0.28
0.0040500


NAV3
1513
1012088
G
N2
0.27
0.0039940


NAV3
1513
1012088
G
G4
0.25
0.0060590


NAV3
1515
7295890
C
G4
0.23
0.0087880


NAV3
1517
7139116
C
N3
0.38
0.0017840


NAV3
1518
10777655
A
N3
0.36
0.0027780


NAV3
1519
438209
A
G13
−0.26
0.0054940


NALCN
1520
12863308
T
G4
0.25
0.0033430


NALCN
1521
9300653
C
G4
0.28
0.0015320


NALCN
1522
9582457
A
G4
0.25
0.0033390


NALCN
1523
896560
T
G2
0.27
0.0031740


NALCN
1525
479648
G
G7
−0.20
0.0065120


NALCN
1526
9513866
G
G2
0.26
0.0030020


NALCN
1526
9513866
G
G4
0.25
0.0016280


NALCN
1527
9513873
C
G4
0.21
0.0070890


NALCN
1528
9513875
G
G4
0.20
0.0093640


NALCN
1529
9557622
G
G3
−0.29
0.0022740


NALCN
1529
9557622
G
G2
−0.22
0.0097580


ITGBL1
1531
1140605
T
G14
−0.39
0.0023940


ITGBL1
1532
4772403
T
G10
−0.17
0.0061000


ITGBL1
1534
9300686
G
P1
−0.66
0.0075520


ITGBL1
1534
9300686
G
G14
−0.38
0.0083450


FGF14
1537
7319796
A
N4
−0.27
0.0063930


FGF14
1541
3916921
T
G14
−0.17
0.0079030


MTIF3
1542
7334690
A
N2
0.30
0.0019510


N4BP2L2
1543
206337
A
G6
0.37
0.0019540


N4BP2L2
1544
1081796
A
G4
0.29
0.0066550


N4BP2L2
1544
1081796
A
P4
0.26
0.0078880


N4BP2L2
1545
169600
A
G6
0.31
0.0056210


N4BP2L2
1546
208431
G
G6
0.30
0.0075390


NBEA
1547
2247674
T
G6
0.59
0.0028400


NBEA
1548
1197852
A
G13
0.30
0.0056870


NBEA
1549
3794388
C
G2
−0.34
0.0076090


NBEA
1549
3794388
C
G12
0.40
0.0030910


NBEA
1550
275960
T
N7
−0.27
0.0089030


NBEA
1551
9545075
C
N7
−0.27
0.0093760


TRPC4
1552
9566247
C
G7
0.23
0.0047640


TRPC4
1552
9566247
C
G14
0.20
0.0028790


TRPC4
1553
9576332
G
G15
0.23
0.0095400


TRPC4
1553
9576332
G
G5
0.24
0.0010710


TRPC4
1553
9576332
G
G14
0.20
0.0025250


TRPC4
1554
7336008
A
N7
0.27
0.0012410


TRPC4
1554
7336008
A
G7
0.22
0.0053720


TRPC4
1555
7338239
G
G5
0.22
0.0017960


TRPC4
1555
7338239
G
N7
0.24
0.0037660


TRPC4
1555
7338239
G
G14
0.19
0.0039390


TRPC4
1555
7338239
G
G7
0.21
0.0095930


TRPC4
1556
2181747
G
G14
−0.23
0.0002923


TRPC4
1557
4943529
C
G14
0.18
0.0045480


TRPC4
1557
4943529
C
G5
0.18
0.0079780


TRPC4
1557
4943529
C
N7
0.21
0.0094170


TRPC4
1559
1556541
C
G14
−0.22
0.0010430


TRPC4
1559
1556541
C
P7
−0.24
0.0003256


TRPC4
1560
1924378
A
G5
−0.19
0.0069170


TRPC4
1561
9548076
A
P4
0.26
0.0073400


TRPC4
1563
1538146
T
P5
0.26
0.0060540


TRPC4
1563
1538146
T
P2
0.45
0.0000059


TRPC4
1564
9594238
C
P2
−0.37
0.0028640


TRPC4
1564
9594238
C
G11
−0.31
0.0046340


TRPC4
1564
9594238
C
P4
−0.27
0.0073630


FNDC3A
1565
4942796
T
G11
0.22
0.0098170


FNDC3A
1565
4942796
T
G15
0.23
0.0084670


FNDC3A
1566
2994379
G
G12
0.37
0.0002755


FNDC3A
1567
2181539
G
G15
0.23
0.0087220


FNDC3A
1568
1983805
G
G12
0.36
0.0004063


KPNA3
1569
3903768
A
G15
−0.22
0.0070320


PCDH17
1570
9527676
G
N7
−0.24
0.0026590


PCDH17
1570
9527676
G
N5
0.29
0.0032020


PCDH17
1571
9591821
A
N5
−0.29
0.0042650


SLAIN1
1572
9530678
A
G2
−0.31
0.0060950


GPC5
1580
9560813
T
G7
0.21
0.0093730


GPC5
1581
634099
C
G3
−0.29
0.0069480


GPC5
1581
634099
C
G2
−0.27
0.0039700


GPC5
1582
10507992
T
P4
0.27
0.0013220


GPC5
1583
17188557
G
P4
0.24
0.0035120


GPC5
1584
913005
T
G13
−0.23
0.0029440


GPC5
1584
913005
T
N1
−0.26
0.0080970


GPC5
1585
9556229
G
N6
0.44
0.0031230


GPC5
1586
6492630
A
N3
−0.22
0.0092900


GPC5
1587
2148226
G
G7
0.20
0.0088650


GPC5
1587
2148226
G
N1
0.31
0.0020230


GPC5
1587
2148226
G
N6
0.25
0.0085330


GPC6
1588
9516222
G
G16
0.32
0.0060390


GPC6
1588
9516222
G
G9
0.40
0.0004041


GPC6
1589
1323974
C
G9
0.36
0.0013320


GPC6
1589
1323974
C
G2
−0.32
0.0046990


GPC6
1590
4394948
C
G6
−0.33
0.0010280


GPC6
1591
7987964
T
G6
−0.31
0.0021180


GPC6
1592
7993501
C
G6
−0.29
0.0041020


GPC6
1595
9561551
C
P3
−0.41
0.0013940


GPC6
1595
9561551
C
G12
−0.34
0.0017870


GPC6
1595
9561551
C
G9
−0.29
0.0054850


GPC6
1596
9561558
G
G14
0.29
0.0061680


NPAS3
1598
1290203
T
G16
−0.27
0.0028010


NPAS3
1598
1290203
T
G6
−0.25
0.0085470


NPAS3
1599
243291
G
P2
−0.25
0.0051370


NPAS3
1600
243284
G
P2
−0.25
0.0060460


NPAS3
1601
10133530
A
G8
0.25
0.0005158


NPAS3
1601
10133530
A
P7
0.22
0.0071150


NPAS3
1601
10133530
A
G1
0.31
0.0066340


NPAS3
1602
6571604
C
G4
−0.34
0.0019570


NPAS3
1602
6571604
C
G2
−0.32
0.0080670


NPAS3
1602
6571604
C
P3
−0.42
0.0046270


NPAS3
1603
6571605
A
G4
−0.29
0.0061820


NPAS3
1604
7144144
C
G11
−0.22
0.0050680


NPAS3
1605
2383521
C
G5
0.18
0.0069980


NPAS3
1605
2383521
C
G11
0.21
0.0096830


NPAS3
1606
11156807
T
G15
0.22
0.0054810


NPAS3
1607
7152838
A
G15
0.23
0.0099530


SLC25A21
1608
12185044
G
G3
−0.51
0.0076230


SLC25A21
1609
1367029
A
G10
−0.16
0.0056360


LRFN5
1610
8020273
G
G4
0.23
0.0055820


LRFN5
1611
12884688
T
G3
−0.33
0.0015010


GNG2
1612
4901168
A
G12
−0.28
0.0086310


GNG2
1613
10138800
A
G14
−0.18
0.0049000


GNG2
1614
12882906
G
G13
0.22
0.0066200


GNG2
1615
10873056
G
G16
−0.79
0.0008798


GNG2
1615
10873056
G
G14
0.52
0.0015880


SAMD4A
1616
1307289
G
G1
0.31
0.0092750


SAMD4A
1617
8006657
A
G15
0.25
0.0040450


SAMD4A
1617
8006657
A
P6
0.33
0.0010530


SAMD4A
1618
709939
C
G4
0.28
0.0004590


SAMD4A
1618
709939
C
P6
0.28
0.0039730


SAMD4A
1619
8021151
G
G4
0.31
0.0001717


PPP2R5E
1620
10137202
C
G7
0.32
0.0046730


PPP2R5E
1620
10137202
C
G3
0.43
0.0027250


PPP2R5E
1621
972984
C
P5
0.28
0.0092860


PPP2R5E
1621
972984
C
N6
−0.43
0.0001646


PPP2R5E
1622
1255741
A
N1
−0.28
0.0071480


PPP2R5E
1622
1255741
A
N4
−0.29
0.0040290


PPP2R5E
1623
7154718
G
P6
0.93
0.0045130


RGS6
1624
36318
G
P6
0.28
0.0050200


RGS6
1624
36318
G
G6
0.26
0.0074530


RGS6
1625
11158926
T
P6
0.29
0.0028720


RGS6
1625
11158926
T
G6
0.29
0.0018240


RGS6
1626
11623588
C
G6
−0.26
0.0063130


RGS6
1627
12586968
G
G8
0.19
0.0045030


RGS6
1628
10151019
A
P5
0.32
0.0054910


RGS6
1629
847241
A
N7
−0.22
0.0057730


RGS6
1630
765221
A
G4
0.26
0.0030130


RGS6
1631
2283380
T
G5
0.20
0.0057700


KCNK10
1632
12587003
C
G6
0.29
0.0049450


KCNK10
1633
12185033
T
P5
−0.24
0.0074730


RPS6KA5
1634
1152423
C
N1
0.27
0.0093070


RPS6KA5
1636
1286148
C
N1
0.33
0.0051490


RPS6KA5
1636
1286148
C
N6
0.35
0.0017090


RPS6KA5
1636
1286148
C
N3
0.27
0.0068710


RPS6KA5
1637
7156252
T
P6
0.41
0.0000700


RPS6KA5
1638
1285989
G
P6
0.31
0.0020140


RPS6KA5
1639
1075014
C
P6
0.38
0.0003627


RPS6KA5
1640
11159988
C
P6
0.36
0.0005594


RPS6KA5
1641
7492628
G
P6
0.32
0.0022000


CCDC88C
1642
4904770
T
P1
−0.41
0.0031170


CCDC88C
1642
4904770
T
P3
−0.40
0.0040540


CCDC88C
1642
4904770
T
G3
−0.36
0.0042010


CCDC88C
1643
8015982
C
P1
−0.34
0.0055030


CCDC88C
1644
10131741
G
P5
−0.27
0.0077650


CCDC88C
1644
10131741
G
P1
−0.34
0.0060010


CCDC88C
1645
8008996
T
P5
−0.26
0.0084630


CCDC88C
1646
8007791
A
P1
−0.34
0.0061070


CCDC88C
1646
8007791
A
P5
−0.26
0.0084630


CCDC88C
1647
11160004
C
G6
0.33
0.0059360


BCL11B
1649
807567
C
P4
0.28
0.0051440


BCL11B
1650
2614463
T
P1
0.28
0.0097100


ATP10A
1652
10873606
A
G3
0.26
0.0085920


RYR3
1653
2572189
T
P4
−0.20
0.0080530


RYR3
1654
2572175
A
G8
−0.16
0.0038570


RYR3
1654
2572175
A
P4
−0.19
0.0088300


RYR3
1655
10519839
G
G5
0.23
0.0007472


RYR3
1656
1390159
T
G10
0.48
0.0009035


RYR3
1657
1495284
C
G10
0.45
0.0010110


RYR3
1658
11638307
A
G7
−0.27
0.0059210


RYR3
1659
8036377
A
G7
−0.23
0.0069290


RYR3
1660
2043054
G
N1
−0.39
0.0002070


C15ORF41
1662
11073189
G
N7
−0.26
0.0058370


C15ORF41
1663
8024344
C
G4
−0.33
0.0077180


C15ORF41
1665
2381888
T
N7
−0.28
0.0023710


C15ORF41
1666
9302317
T
N7
−0.25
0.0059890


C15ORF41
1667
1990659
A
N7
−0.22
0.0076630


RASGRP1
1668
11855910
G
G12
0.26
0.0097590


PLA2G4D
1669
776699
A
N4
0.52
0.0035160


GLDN
1671
17648128
A
P5
0.25
0.0069100


GLDN
1672
17648140
G
P4
0.20
0.0090160


CGNL1
1673
12595188
G
G8
0.21
0.0036450


CGNL1
1674
7182648
T
N4
−0.37
0.0013360


CGNL1
1675
8034215
G
N4
−0.30
0.0034690


CGNL1
1676
16977561
A
N5
−0.42
0.0058780


CGNL1
1677
1620402
G
G10
−0.20
0.0053030


CGNL1
1678
1623697
G
G10
−0.19
0.0078490


RORA
1679
12914584
G
G4
−0.24
0.0075730


RORA
1680
4774370
C
N1
0.33
0.0092280


CLK3
1681
12441932
G
N1
0.40
0.0069560


TBC1D2B
1683
8030999
G
P3
0.52
0.0012850


TBC1D2B
1683
8030999
G
G10
0.25
0.0041290


TBC1D2B
1683
8030999
G
G14
0.27
0.0036100


TBC1D2B
1684
11634607
T
N4
0.30
0.0024460


TBC1D2B
1684
11634607
T
G11
0.29
0.0008413


ARNT2
1686
8041887
A
G6
0.24
0.0090900


ARNT2
1687
4778835
G
N4
−0.28
0.0088630


ARNT2
1688
4628923
C
P1
−0.41
0.0007190


ARNT2
1688
4628923
C
N4
−0.27
0.0099790


ARNT2
1689
11072931
T
P1
−0.43
0.0034780


ARNT2
1690
7180510
G
P1
−0.36
0.0040010


ARNT2
1691
4778615
T
P3
−0.39
0.0086420


ARNT2
1691
4778615
T
P1
−0.38
0.0098670


SH3GL3
1692
10520577
T
P2
0.32
0.0021760


PCSK6
1693
11247300
A
G15
0.32
0.0051620


GDE1
1695
12447418
G
P5
0.30
0.0064830


A2BP1
1699
1476979
T
G1
0.24
0.0059520


A2BP1
1700
11077043
G
G1
0.24
0.0062720


A2BP1
1702
4289011
C
G7
−0.27
0.0007420


HYDIN
1703
1424137
G
N4
−0.31
0.0015820


A2BP1
1704
8055711
T
G7
−0.26
0.0026420


HYDIN
1705
9939194
T
N4
−0.30
0.0019340


A2BP1
1706
11860241
G
G12
0.27
0.0049040


A2BP1
1707
1507031
A
G10
0.16
0.0071550


WWOX
1708
8061908
C
N7
−0.25
0.0027750


WWOX
1709
1922620
C
N7
−0.23
0.0043490


WWOX
1710
2344926
G
N7
−0.22
0.0088960


WWOX
1711
11641213
G
P6
0.27
0.0060550


WWOX
1712
7184271
C
P6
0.26
0.0079320


WWOX
1713
7201683
G
G3
−1.14
0.0068500


MPHOSPH6
1714
7405231
C
P5
0.24
0.0033010


MPHOSPH6
1715
8052512
T
G6
−0.40
0.0021070


MPHOSPH6
1716
8047857
C
G6
−0.37
0.0060150


MPHOSPH6
1717
4530129
C
G6
−0.38
0.0088290


CDH13
1718
4598906
T
G8
−0.17
0.0037190


CDH13
1719
11150496
T
N7
0.24
0.0026140


CDH13
1720
4782734
T
N7
0.22
0.0072300


CDH13
1721
9933935
T
G3
0.27
0.0087900


CDH13
1723
4783293
C
G3
0.27
0.0093560


CDH13
1724
7201829
T
N7
0.27
0.0041410


CDH13
1725
11150517
T
N1
0.36
0.0031150


CDH13
1726
1035569
G
G14
−0.20
0.0040860


CDH13
1727
10514579
C
G14
−0.20
0.0045860


CDH13
1728
11864731
A
G14
−0.19
0.0026430


CDH13
1729
1833965
A
N5
0.27
0.0098150


USP10
1731
744839
T
N1
−0.30
0.0024100


USP10
1732
8060725
A
N2
0.27
0.0031360


CRISPLD2
1733
2641697
C
P7
0.19
0.0042800


CRISPLD2
1735
16974822
G
G9
−0.31
0.0030320


CRISPLD2
1735
16974822
G
P2
−0.28
0.0079670


CRISPLD2
1736
774205
G
P4
0.22
0.0040940


CRISPLD2
1737
11149692
C
P3
−0.34
0.0076950


CRISPLD2
1737
11149692
C
P5
−0.34
0.0007284


CRISPLD2
1738
982994
T
P4
0.21
0.0083490


CRISPLD2
1738
982994
T
P5
0.24
0.0092360


CRISPLD2
1739
2646107
C
P5
−0.27
0.0071640


DNAH9
1740
3744581
G
P4
−0.23
0.0046180


DNAH9
1741
16945383
G
G9
0.28
0.0012220


RAB11FIP4
1743
315431
T
G1
−0.33
0.0007109


CA10
1744
11869209
C
P4
0.22
0.0054890


CA10
1745
4794315
G
P4
−0.23
0.0012360


CA10
1746
1393735
G
P4
−0.22
0.0019830


CA10
1747
1875675
T
P4
0.25
0.0006519


CA10
1748
9893317
A
P4
0.26
0.0005388


CA10
1749
11652641
G
G4
−0.29
0.0041050


CA10
1749
11652641
G
G12
−0.33
0.0048860


CA10
1749
11652641
G
P4
−0.31
0.0008907


CA10
1750
12942636
T
P6
−0.32
0.0022370


MSI2
1751
8066677
G
G6
−0.28
0.0059210


MSI2
1751
8066677
G
G7
−0.23
0.0054900


MSI2
1753
8077599
A
N1
−0.30
0.0030850


SDK2
1754
1846334
A
P3
−0.32
0.0055460


HRNBP3
1755
907898
C
P6
0.44
0.0064750


HRNBP3
1756
4313839
C
G3
0.29
0.0035960


OSBPL1A
1757
6508259
A
G6
−0.35
0.0016990


OSBPL1A
1758
275857
C
G16
0.61
0.0059070


OSBPL1A
1758
275857
C
P4
0.48
0.0092890


OSBPL1A
1758
275857
C
N4
0.71
0.0021820


OSBPL1A
1758
275857
C
N7
0.56
0.0042880


CHST9
1760
17703962
G
G3
0.37
0.0091660


CHST9
1761
9949654
C
G9
0.40
0.0003672


DLGAP1
1763
9635857
G
P1
0.40
0.0014780


DLGAP1
1763
9635857
G
P3
0.45
0.0004842


DLGAP1
1764
7245298
G
P3
0.43
0.0016550


ZFP161
1765
9965501
T
G4
−0.76
0.0026240


NEDD4L
1773
11152073
A
P3
0.36
0.0047540


CCBE1
1774
12969965
A
P2
0.28
0.0099730


CCBE1
1775
4488565
C
P5
−0.25
0.0064570


CDH7
1776
2658046
C
G14
0.17
0.0052290


CDH7
1777
7241038
T
G14
0.17
0.0060130


CDH7
1778
4455070
T
G14
0.16
0.0081910


CDH7
1779
976882
A
G14
0.16
0.0090970


CDH7
1780
7237421
T
N3
0.27
0.0016680


CDH7
1780
7237421
T
N5
0.27
0.0098740


CDH7
1781
8092259
G
N3
0.27
0.0024310


CDH7
1783
1942832
A
N3
0.26
0.0033240


CDH7
1784
1942831
G
N3
0.26
0.0035760


CDH7
1785
8093720
A
N3
0.25
0.0046980


CDH7
1786
1484725
T
N3
0.25
0.0050040


CDH7
1786
1484725
T
N2
0.28
0.0017760


CDH7
1787
1994230
T
P6
0.53
0.0075190


CDH7
1788
8089669
A
G4
0.23
0.0052220


CDH7
1789
12606480
C
G4
0.21
0.0082640


CDH7
1790
1564815
C
N3
0.54
0.0067680


DOK6
1791
12961718
C
G7
0.23
0.0063950


DOK6
1793
4426448
G
G9
0.30
0.0008687


DOK6
1793
4426448
G
P2
0.29
0.0016190


DOK6
1793
4426448
G
P5
0.23
0.0097090


DOK6
1794
12605879
G
P1
0.30
0.0057610


DOK6
1794
12605879
G
G9
0.28
0.0013060


DOK6
1794
12605879
G
P2
0.27
0.0025790


MBP
1795
470181
G
G12
0.30
0.0026850


MBP
1796
11660442
A
G13
0.22
0.0072860


PTPRM
1798
8089695
C
N1
0.62
0.0008150


PTPRM
1799
6506570
A
G1
−0.27
0.0031230


PTPRM
1800
6506572
T
G2
−0.25
0.0091560


PTPRM
1801
9949149
C
G2
−0.24
0.0094030


KIAA0802
1802
4798677
A
G1
0.25
0.0042410


KIAA0802
1803
12386117
A
G6
−0.35
0.0094890


KIAA0802
1803
12386117
A
G5
−0.25
0.0099120


KIAA0802
1804
7235093
A
N3
0.54
0.0001818


KIAA0802
1804
7235093
A
N1
0.64
0.0001433


LDLR
1806
2116897
T
P6
0.31
0.0091270


LDLR
1807
1433099
A
G14
−0.19
0.0080220


ZNF667
1808
7251105
G
G14
−0.19
0.0042940


MACROD2
1809
6079395
G
N5
0.27
0.0075940


MACROD2
1811
11697488
T
P1
0.35
0.0027420


MACROD2
1812
809587
G
N7
0.25
0.0079290


KIF16B
1813
6043875
C
P6
−0.28
0.0061930


KIF16B
1813
6043875
C
G2
−0.24
0.0076280


KIF16B
1813
6043875
C
G1
−0.24
0.0066360


KIF16B
1813
6043875
C
G16
−0.27
0.0041690


KIF16B
1813
6043875
C
G3
−0.26
0.0086990


KIF16B
1813
6043875
C
G6
−0.32
0.0009477


KIF16B
1814
6111022
T
G16
0.28
0.0049120


KIF16B
1815
4814474
A
G1
0.25
0.0064230


KIF16B
1815
4814474
A
G16
0.24
0.0080570


KIF16B
1816
6034462
T
P6
−0.29
0.0040210


KIF16B
1817
2328019
C
G6
−0.25
0.0089580


KIF16B
1817
2328019
C
P6
−0.26
0.0094690


KIF16B
1818
6135739
G
P6
−0.29
0.0042470


KIF16B
1819
6111075
T
G6
−0.26
0.0081000


KIF16B
1820
6111076
C
P6
−0.27
0.0063350


KIF16B
1821
6034464
A
G1
−0.24
0.0073690


KIF16B
1822
2876428
C
G6
−0.25
0.0086240


KIF16B
1823
12624938
A
G7
0.30
0.0046690


KIF16B
1824
2143988
A
G7
0.23
0.0026840


KIF16B
1825
7352372
G
G1
0.28
0.0090750


KIF16B
1826
6075069
T
G1
0.42
0.0003007


KIF16B
1826
6075069
T
G2
0.30
0.0079190


KIF16B
1826
6075069
T
P2
−0.32
0.0072410


KIF16B
1826
6075069
T
G3
0.41
0.0012840


KIF16B
1827
6080359
C
N1
−0.36
0.0018350


MAPRE1
1828
410488
A
G16
0.27
0.0029080


MAPRE1
1829
2070090
T
G8
0.24
0.0020120


MAPRE1
1829
2070090
T
G14
0.29
0.0007217


PTPRT
1830
4810349
T
P5
0.24
0.0055900


PTPRT
1831
2013923
G
P5
0.25
0.0060750


PTPRT
1833
746413
C
P1
0.35
0.0013050


PTPRT
1833
746413
C
N6
−0.28
0.0029880


PTPRT
1834
6065434
T
N6
−0.27
0.0068540


PTPRT
1836
6065487
A
P2
−0.27
0.0048940


PTPRT
1837
4810366
C
G10
0.19
0.0043630


PTPRT
1838
2017914
G
G7
0.22
0.0080940


PTPRT
1838
2017914
G
G10
0.19
0.0041790


PTPRT
1839
6072869
G
N5
0.33
0.0050000


PRNT
1840
6052824
A
G1
0.27
0.0075650


KCNB1
1842
9636516
A
P3
0.36
0.0025780


KCNB1
1843
496511
C
G6
−0.28
0.0040330


KCNB1
1844
6095546
A
G2
−0.29
0.0039110


KCNB1
1845
4647
T
G2
−0.28
0.0058190


KCNB1
1845
4647
T
P3
−0.33
0.0096390


CDH4
1848
6089265
T
G2
−0.32
0.0021190


CDH4
1849
1891572
T
N5
−0.28
0.0055020


CDH4
1850
17811544
G
N5
−0.27
0.0059340


CDH4
1850
17811544
G
P4
−0.19
0.0083060


CDH4
1851
6142884
A
G15
−0.22
0.0061750


FERMT1
1852
6117072
C
G12
−0.29
0.0021930


FERMT1
1853
6085406
A
G4
−0.25
0.0019890


FERMT1
1854
10373
T
G4
−0.24
0.0033280


PLCB1
1857
2235212
A
P1
0.35
0.0057060


PLCB1
1858
6055678
T
G16
0.33
0.0040720


C21ORF37
1861
12483129
C
N2
0.26
0.0025100


C21ORF37
1861
12483129
C
N6
0.27
0.0033900


NCAM2
1862
2826830
G
G11
0.27
0.0059510


NCAM2
1862
2826830
G
G4
0.28
0.0041390


NCAM2
1863
3787603
G
G11
0.26
0.0079430


NCAM2
1864
1599228
C
N3
0.30
0.0015950


ERG
1865
461592
C
G9
−0.30
0.0030480


ERG
1865
461592
C
N7
−0.27
0.0033130


ERG
1866
461488
G
N7
−0.26
0.0036820


ERG
1867
2070527
A
G9
−0.27
0.0062580


PCP4
1868
2837257
C
G3
0.30
0.0064480


PCP4
1868
2837257
C
G6
0.34
0.0016930


PCP4
1869
398802
G
G15
0.24
0.0076060


SLC37A1
1870
412212
C
N5
−0.34
0.0048170


SLC37A1
1872
381899
A
N5
−0.32
0.0049270


SLC37A1
1872
381899
A
N4
−0.28
0.0093920


ARVCF
1873
2239395
G
P5
0.66
0.0098270


HPS4
1875
739289
C
G9
0.40
0.0049610


ARFGAP3
1876
6002963
G
G10
−0.18
0.0037870


ARFGAP3
1877
738536
A
G6
0.33
0.0005261


ARFGAP3
1878
4822208
T
G6
0.31
0.0007756


PACSIN2
1879
1076118
T
G10
−0.18
0.0020710


PACSIN2
1880
738383
C
G6
0.31
0.0010780


PACSIN2
1881
1071960
C
N6
0.26
0.0072050


PACSIN2
1882
4140554
C
G10
−0.17
0.0033560


PACSIN2
1883
7291153
C
G10
−0.17
0.0052570


PACSIN2
1883
7291153
C
G6
−0.28
0.0033790


PACSIN2
1884
1569507
G
G10
−0.17
0.0056840


PACSIN2
1885
5751410
A
G10
−0.16
0.0083500


PACSIN2
1886
713717
T
G6
0.28
0.0033910


PACSIN2
1887
737782
G
G6
0.27
0.0048780


PACSIN2
1889
738379
A
G10
−0.16
0.0084240


TTLL1
1890
2076156
G
G8
0.33
0.0041600


TTLL1
1891
135001
C
P7
0.17
0.0063380


TTLL1
1892
135002
C
P7
0.17
0.0072570


EFCAB6
1894
12628583
C
G2
−0.37
0.0082480
















TABLE A







Summary of SNPs (NCBI Human Genome Reference Assembly Build 36.3)














Seq ID
Gene
Chr
Position (BP)
Seq ID
Gene
Chr
Position (BP)

















1
KIF1B
1
10,279,993
2
KIF1B
1
10,320,154


3
KIF1B
1
10,323,189
4
KIF1B
1
10,343,505


5
SYT6
1
114,452,599
6
NGF
1
115,631,509


7
NGF
1
115,664,140
8
SLC22A15
1
116,328,295


9
SLC22A15
1
116,329,613
10
SLC22A15
1
116,353,502


11
SLC22A15
1
116,381,302
12
PTGFRN
1
117,269,213


13
PTGFRN
1
117,273,572
14
PTGFRN
1
117,284,884


15
PTGFRN
1
117,333,336
16
CGN
1
149,743,817


17
RP1-21O18.1
1
15,214,000
18
RP1-21O18.1
1
15,265,882


19
RP1-21O18.1
1
15,278,076
20
RP1-21O18.1
1
15,281,743


21
RP1-21O18.1
1
15,285,942
22
RP1-21O18.1
1
15,316,063


23
ATF6
1
160,062,520
24
ATF6
1
160,107,168


25
OLFML2B
1
160,230,414
26
OLFML2B
1
160,234,305


27
OLFML2B
1
160,247,126
28
FAM78B
1
164,309,282


29
FAM78B
1
164,314,302
30
SEC16B
1
176,215,337


31
RALGPS2
1
176,976,589
32
RALGPS2
1
177,051,615


33
KCNK2
1
213,266,926
34
KCNK2
1
213,387,083


35
KCNK2
1
213,405,370
36
KCNK2
1
213,405,685


37
KCNK2
1
213,412,561
38
KCNK2
1
213,426,881


39
KCNK2
1
213,474,680
40
USH2A
1
213,526,280


41
USH2A
1
213,537,370
42
USH2A
1
213,911,770


43
USH2A
1
213,954,742
44
USH2A
1
213,955,280


45
USH2A
1
214,404,070
46
USH2A
1
214,404,156


47
USH2A
1
214,498,585
48
USH2A
1
214,506,786


49
USH2A
1
214,572,091
50
ESRRG
1
214,788,713


51
ESRRG
1
214,789,473
52
ESRRG
1
214,827,730


53
ESRRG
1
214,836,783
54
ESRRG
1
214,855,550


55
ESRRG
1
214,861,049
56
ESRRG
1
214,950,266


57
EPHB2
1
22,984,956
58
EPHB2
1
23,091,301


59
SLC35F3
1
232,525,097
60
RYR2
1
235,413,480


61
RYR2
1
235,435,907
62
RYR2
1
235,500,248


63
RYR2
1
235,513,475
64
RYR2
1
235,569,612


65
RYR2
1
235,661,657
66
RYR2
1
235,795,490


67
RYR2
1
235,805,642
68
RYR2
1
236,056,960


69
CHRM3
1
237,894,973
70
CHRM3
1
237,911,900


71
CHRM3
1
237,937,398
72
CHRM3
1
237,944,344


73
CHRIVI3
1
237,958,134
74
CHRM3
1
237,969,464


75
CHRM3
1
237,996,528
76
FMN2
1
238,349,704


77
FMN2
1
238,353,478
78
FMN2
1
238,416,539


79
FMN2
1
238,426,833
80
FMN2
1
238,455,099


81
FMN2
1
238,486,712
82
FMN2
1
238,494,888


83
FMN2
1
238,512,719
84
FMN2
1
238,525,003


85
FMN2
1
238,669,725
86
FMN2
1
238,670,023


87
RGS7
1
239,588,948
88
PLD5
1
240,632,975


89
CLIC4
1
24,963,033
90
CLIC4
1
24,970,832


91
AGBL4-C1ORF165
1
48,833,568
92
AGBL4-C1ORF165
1
49,006,963


93
AGBL4-C1ORF165
1
49,124,764
94
AGBL4-C1ORF165
1
49,125,312


95
AGBL4-C1ORF165
1
49,133,207
96
AGBL4-C1ORF165
1
49,239,649


97
AGBL4-C1ORF165
1
49,243,353
98
SCP2
1
53,287,104


99
LRP8
1
53,561,462
100
ELTD1
1
79,259,313


101
ELTD1
1
79,260,672
102
PRKACB
1
84,299,506


103
PRKACB
1
84,301,022
104
PRKACB
1
84,450,848


105
HPCAL1
2
10,301,740
106
KCNF1
2
10,981,799


107
KCNF1
2
10,999,213
108
NTSR2
2
11,726,315


109
NAPS
2
133,607,512
110
NAPS
2
133,642,409


111
RAB3GAP1
2
135,514,217
112
RAB3GAP1
2
135,541,544


113
RAB3GAP1
2
135,649,190
114
ZRANB3
2
135,868,244


115
ZRANB3
2
135,981,101
116
NXPH2
2
139,154,184


117
LRP1B
2
140,708,533
118
LRP1B
2
140,730,389


119
LRP1B
2
140,740,113
120
LRP1B
2
140,749,675


121
LRP1B
2
140,986,740
122
LRP1B
2
141,715,030


123
LRP1B
2
141,896,198
124
LRP1B
2
142,066,600


125
LRP1B
2
142,278,834
126
LRP1B
2
142,283,237


127
LRP1B
2
142,284,380
128
LRP1B
2
142,293,931


129
KYNU
2
143,368,826
130
KYNU
2
143,405,309


131
KYNU
2
143,430,832
132
KYNU
2
143,455,211


133
KYNU
2
143,598,044
134
ARHGAP15
2
143,651,019


135
ARHGAP15
2
143,685,981
136
ARHGAP15
2
143,769,771


137
ARHGAP15
2
143,884,507
138
ARHGAP15
2
143,903,015


139
ARHGAP15
2
143,961,757
140
ARHGAP15
2
144,294,622


141
ARHGAP15
2
144,295,364
142
KIF5C
2
149,333,649


143
KIF5C
2
149,600,091
144
FMNL2
2
152,981,465


145
FMNL2
2
153,122,655
146
FMNL2
2
153,166,996


147
FMNL2
2
153,201,156
148
FMNL2
2
153,207,856


149
KCNJ3
2
155,324,938
150
KCNJ3
2
155,326,572


151
KCNJ3
2
155,411,014
152
PKP4
2
159,148,211


153
PKP4
2
159,155,564
154
PKP4
2
159,163,035


155
PKP4
2
159,168,396
156
PKP4
2
159,172,437


157
PKP4
2
159,204,636
158
PKP4
2
159,219,409


159
PKP4
2
159,232,049
160
PLA2R1
2
160,519,430


161
PLA2R1
2
160,543,237
162
PLA2R1
2
160,575,799


163
PLA2R1
2
160,616,115
164
KCNH7
2
163,221,260


165
SCN3A
2
165,732,374
166
SCN1A
2
166,606,495


167
SCN1A
2
166,629,033
168
SCN1A
2
166,650,019


169
SCN9A
2
166,781,097
170
SCN9A
2
166,784,624


171
SCN9A
2
166,807,404
172
SCN9A
2
166,817,960


173
SCN9A
2
166,871,909
174
SCN9A
2
166,874,107


175
SCN7A
2
166,989,998
176
CERKL
2
182,239,099


177
PDE1A
2
182,752,922
178
PDE1A
2
182,763,240


179
PDE1A
2
182,767,445
180
PDE1A
2
182,804,991


181
PDE1A
2
182,821,396
182
PDE1A
2
182,833,270


183
PDE1A
2
182,871,393
184
PDE1A
2
182,886,451


185
PDE1A
2
182,910,657
186
PDE1A
2
182,918,516


187
PDE1A
2
182,932,372
188
PDE1A
2
182,971,998


189
PDE1A
2
183,029,113
190
PDE1A
2
183,067,065


191
ALS2
2
202,315,109
192
ALS2
2
202,354,735


193
PARD3B
2
205,291,115
194
PARD3B
2
205,326,956


195
PARD3B
2
205,347,353
196
PARD3B
2
205,858,397


197
PARD3B
2
205,866,562
198
PARD3B
2
205,906,564


199
PARD3B
2
205,932,117
200
PARD3B
2
205,955,695


201
PARD3B
2
205,967,382
202
PARD3B
2
206,172,710


203
NRP2
2
206,426,955
204
NRP2
2
206,441,948


205
NRP2
2
206,443,765
206
PIP5K3
2
208,948,035


207
PIP5K3
2
208,956,492
208
ERBB4
2
211,933,765


209
ERBB4
2
211,975,964
210
ERBB4
2
212,022,377


211
CUL3
2
225,109,321
212
IRS1
2
227,388,355


213
COL4A4
2
227,619,969
214
COL4A4
2
227,630,259


215
COL4A3
2
227,795,722
216
DNER
2
229,972,935


217
DNER
2
230,024,102
218
ECEL1
2
233,048,959


219
CHRNG
2
233,127,640
220
SAG
2
233,900,559


221
SAG
2
233,902,504
222
KLHL29
2
23,504,556


223
KLHL29
2
23,504,709
224
KLHL29
2
23,504,805


225
KLHL29
2
23,507,416
226
KLHL29
2
23,519,201


227
KLHL29
2
23,782,141
228
KCNK3
2
26,798,797


229
KCNK3
2
26,807,044
230
DPYSL5
2
26,957,635


231
DPYSL5
2
26,986,326
232
DPYSL5
2
27,023,044


233
BRE
2
28,212,255
234
BRE
2
28,243,350


235
BRE
2
28,373,587
236
BRE
2
28,396,438


237
CRIM1
2
36,443,527
238
CRIM1
2
36,471,032


239
CRIM1
2
36,477,691
240
CRIM1
2
36,510,809


241
CRIM1
2
36,523,515
242
CRIM1
2
36,535,123


243
CRIM1
2
36,549,124
244
CRIM1
2
36,581,523


245
CRIM1
2
36,581,946
246
SLC8A1
2
40,230,588


247
SLC8A1
2
40,241,861
248
SLC8A1
2
40,253,816


249
SLC8A1
2
40,267,644
250
SLC8A1
2
40,524,155


251
SLC8A1
2
40,524,198
252
HAAO
2
42,918,059


253
PLEKHH2
2
43,822,986
254
PLEKHH2
2
43,823,791


255
PLEKHH2
2
43,839,444
256
PLEKHH2
2
43,846,952


257
C2ORF34
2
44,446,479
258
C2ORF34
2
44,457,570


259
C2ORF34
2
44,474,546
260
C2ORF34
2
44,500,542


261
C2ORF34
2
44,501,551
262
C2ORF34
2
44,508,409


263
C2ORF34
2
44,514,120
264
C2ORF34
2
44,529,730


265
C2ORF34
2
44,536,723
266
C2ORF34
2
44,574,451


267
C2ORF34
2
44,584,000
268
C2ORF34
2
44,621,606


269
C2ORF34
2
44,631,967
270
C2ORF34
2
44,641,482


271
C2ORF34
2
44,645,163
272
C2ORF34
2
44,686,360


273
C2ORF34
2
44,715,296
274
C2ORF34
2
44,834,212


275
C2ORF34
2
44,834,623
276
PRKCE
2
45,737,717


277
PRKCE
2
46,130,026
278
PRKCE
2
46,226,779


279
EPAS1
2
46,401,568
280
FBXO11
2
47,952,212


281
FBXO11
2
47,978,008
282
PSME4
2
53,957,822


283
PSME4
2
54,001,835
284
PSME4
2
54,018,352


285
PSME4
2
54,055,952
286
PSME4
2
54,064,285


287
ACYP2
2
54,189,467
288
ACYP2
2
54,329,389


289
ACYP2
2
54,329,418
290
ACYP2
2
54,350,261


291
CCDC85A
2
56,266,849
292
CCDC85A
2
56,312,732


293
CCDC85A
2
56,344,184
294
CCDC85A
2
56,416,774


295
CCDC85A
2
56,493,023
296
OTX1
2
63,151,654


297
AAK1
2
69,639,692
298
AAK1
2
69,768,980


299
AAK1
2
69,834,530
300
CTNNA2
2
79,631,620


301
CTNNA2
2
79,635,253
302
CTNNA2
2
79,644,485


303
CTNNA2
2
79,648,869
304
CTNNA2
2
79,728,810


305
CTNNA2
2
80,246,403
306
CTNNA2
2
80,346,411


307
CTNNA2
2
80,348,223
308
CTNNA2
2
80,493,928


309
CTNNA2
2
80,498,999
310
CTNNA2
2
80,652,425


311
CTNNA2
2
80,657,667
312
CTNNA2
2
80,663,934


313
C2ORF46
2
8,262,682
314
C2ORF46
2
8,361,310


315
C2ORF46
2
8,384,366
316
DDEF2
2
9,458,300


317
INPP4A
2
98,437,334
318
INPP4A
2
98,502,170


319
ATP2B2
3
10,358,996
320
PLCXD2
3
112,883,336


321
PLCXD2
3
112,941,527
322
PLCXD2
3
112,944,650


323
PLCXD2
3
112,961,319
324
PLCXD2
3
112,964,847


325
CDGAP
3
120,527,813
326
STXBP5L
3
122,476,483


327
KALRN
3
125,928,594
328
CNTN6
3
1,268,504


329
CNTN6
3
1,292,727
330
CPNE4
3
132,865,247


331
CPNE4
3
132,865,495
332
CPNE4
3
132,885,425


333
CPNE4
3
132,886,287
334
CPNE4
3
132,889,696


335
CPNE4
3
132,890,801
336
CPNE4
3
132,907,690


337
CPNE4
3
133,142,633
338
CPNE4
3
133,145,979


339
CNTN6
3
1,336,323
340
RAB6B
3
135,041,388


341
CNTN6
3
1,350,581
342
CNTN6
3
1,357,151


343
CNTN6
3
1,357,358
344
EPHBI
3
136,133,973


345
EPHB1
3
136,152,557
346
EPHB1
3
136,153,214


347
EPHB1
3
136,154,213
348
EPHB1
3
136,154,975


349
EPHB1
3
136,156,084
350
EPHB1
3
136,158,491


351
EPHB1
3
136,165,323
352
EPHB1
3
136,172,644


353
CNTN6
3
1,375,419
354
CNTN6
3
1,399,850


355
CLSTN2
3
141,648,210
356
CLSTN2
3
141,660,969


357
CLSTN2
3
141,661,175
358
CLSTN2
3
141,662,920


359
CLSTN2
3
141,663,200
360
CLSTN2
3
141,764,774


361
CLSTN2
3
141,774,103
362
CLSTN2
3
141,775,226


363
SPSB4
3
142,258,988
364
SPSB4
3
142,287,637


365
SLC6A6
3
14,421,894
366
DAZL
3
16,611,406


367
DAZL
3
16,611,469
368
DAZL
3
16,627,901


369
SERPINI1
3
169,041,318
370
SERPINI1
3
169,077,645


371
SLC7A14
3
171,678,031
372
SLC7A14
3
171,682,206


373
PLD1
3
172,791,538
374
PLD1
3
172,887,172


375
PLD1
3
172,897,589
376
PLD1
3
172,954,990


377
PLD1
3
172,963,579
378
PLD1
3
172,989,645


379
PLD1
3
172,991,671
380
NLGN1
3
175,384,416


381
NLGN1
3
175,458,980
382
NLGN1
3
175,493,649


383
NLGN1
3
175,515,979
384
NLGN1
3
175,541,245


385
HTR3D
3
185,232,425
386
HTR3D
3
185,236,739


387
HTR3E
3
185,313,087
388
LEPREL1
3
191,236,401


389
LEPREL1
3
191,237,107
390
LEPREL1
3
191,261,577


391
LEPREL1
3
191,280,803
392
LEPREL1
3
191,356,831


393
IL1RAP
3
191,892,719
394
IL1RAP
3
191,914,687


395
LRRC15
3
195,586,726
396
CENTB2
3
196,483,019


397
CENTB2
3
196,647,738
398
UBXD7
3
197,608,675


399
CNTN4
3
2,375,967
400
RARB
3
25,544,885


401
RARB
3
25,589,536
402
RARB
3
25,592,407


403
RARB
3
25,593,163
404
CNTN4
3
2,734,283


405
CNTN4
3
3,035,913
406
CNTN4
3
3,073,041


407
CLASP2
3
33,516,308
408
CLASP2
3
33,516,362


409
CLASP2
3
33,537,118
410
CLASP2
3
33,668,798


411
CLASP2
3
33,726,022
412
ARPP-21
3
35,760,612


413
STAC
3
36,407,617
414
ULK4
3
41,482,456


415
ULK4
3
41,507,554
416
ULK4
3
41,563,607


417
ULK4
3
41,564,968
418
ULK4
3
41,574,775


419
ULK4
3
41,575,331
420
ULK4
3
41,971,140


421
ITPR1
3
4,729,125
422
ITPR1
3
4,846,598


423
SEMA3F
3
50,180,966
424
SEMA3F
3
50,182,079


425
SEMA3F
3
50,199,229
426
CACNA2D2
3
50,451,382


427
CACNA2D3
3
54,127,859
428
CACNA2D3
3
54,331,793


429
ERC2
3
55,743,028
430
ERC2
3
55,757,809


431
ERC2
3
55,760,546
432
ERC2
3
55,828,309


433
ERC2
3
55,877,492
434
ERC2
3
55,902,605


435
ERC2
3
56,116,883
436
ERC2
3
56,119,301


437
ERC2
3
56,164,173
438
ERC2
3
56,298,486


439
ERC2
3
56,318,391
440
ERC2
3
56,347,766


441
ERC2
3
56,348,984
442
ERC2
3
56,360,378


443
ERC2
3
56,368,109
444
ERC2
3
56,393,831


445
ERC2
3
56,410,435
446
ERC2
3
56,414,093


447
ERC2
3
56,422,909
448
ERC2
3
56,433,200


449
ERC2
3
56,462,620
450
ERC2
3
56,464,816


451
ERC2
3
56,491,685
452
ERC2
3
56,496,204


453
BRC2
3
56,496,259
454
FHIT
3
59,814,275


455
FHIT
3
59,824,587
456
FHIT
3
60,462,353


457
FHIT
3
61,135,266
458
FHIT
3
61,137,444


459
PTPRG
3
61,709,002
460
PTPRG
3
61,709,579


461
PTPRG
3
61,723,402
462
PTPRG
3
61,753,808


463
PTPRG
3
62,036,852
464
PTPRG
3
62,219,484


465
PTPRC
3
62,219,610
466
PTPRG
3
62,256,476


467
CADPS
3
62,480,839
468
CADPS
3
62,487,886


469
CADPS
3
62,498,262
470
CADPS
3
62,503,301


471
CADPS
3
62,716,081
472
CADPS
3
62,748,900


473
CADPS
3
62,748,989
474
CADPS
3
62,777,879


475
CADI'S
3
62,786,626
476
CADPS
3
62,789,812


477
CADPS
3
62,801,974
478
SVKPR
3
63,493,103


479
PRICKLE2
3
64,091,416
480
PRICKLE2
3
64,176,516


481
MAGI1
3
65,330,646
482
MAGI1
3
65,337,837


483
MAGI1
3
65,476,046
484
MAGI1
3
65,576,717


485
FAM19A1
3
68,409,920
486
FAM19A1
3
68,470,682


487
FOXP1
3
70,972,978
488
FOXP1
3
71,021,299


489
FOXP1
3
71,295,488
490
GBE1
3
81,633,005


491
GBE1
3
81,643,783
492
GBE1
3
81,669,129


493
GBE1
3
81,687,469
494
GBE1
3
81,687,869


495
GBE1
3
81,694,225
496
GBE1
3
81,816,787


497
GBE1
3
81,859,450
498
GBE1
3
81,888,207


499
GBE1
3
81,894,474
500
HTR1F
3
88,105,976


501
EPHA6
3
97,967,793
502
EPHA6
3
98,268,377


503
EPHA6
3
98,270,901
504
DKJC2
4
108,073,445


SOS
DKK2
4
108,257,617
506
PAPSS1
4
108,875,283


507
COL25A1
4
109,954,162
508
COL25A1
4
110,179,691


509
COL25A1
4
110,189,985
510
COL2SA1
4
110,198,274


511
COL25A1
4
110,198,580
512
ANK2
4
114,298,380


513
ANK2
4
114,298,464
514
ANK2
4
114,298,576


515
ANK2
4
114,399,491
516
ANK2
4
114,424,380


517
ANK2
4
114,436,352
518
ANK2
4
114,445,280


519
CAMK2D
4
114,723,041
520
CAMK2D
4
114,723,767


521
NDST3
4
119,197,389
522
NDST3
4
119,312,058


523
PRSS12
4
119,462,492
524
GPR103
4
122,518,528


525
MAML3
4
140,868,325
526
MAML3
4
140,870,180


527
ILI5
4
142,929,173
528
INPP4B
4
143,195,583


529
INPP4B
4
143,201,848
530
INPP4B
4
143,221,023


531
INPP4B
4
143,222,465
532
INPP4B
4
143,223,756


533
INPP4B
4
143,262,085
534
INPP4B
4
143,264,932


535
INPP4B
4
143,269,935
536
INPP4B
4
143,405,941


537
INPP4B
4
143,476,047
538
POU4F2
4
147,768,753


539
LDB2
4
16,200,696
540
LDB2
4
16,208,501


541
FSTL5
4
162,696,532
542
FSTL5
4
162,744,370


543
FSTL5
4
162,828,621
544
FSTL5
4
162,852,707


545
FSTL5
4
163,022,990
546
FSTL5
4
163,038,911


547
FSTL5
4
163,171,406
548
FSTL5
4
163,275,058


549
FSTL5
4
163,281,294
550
FSTL5
4
163,316,581


551
FSTL5
4
163,369,235
552
LDB2
4
16,363,986


553
LDB2
4
16,365,914
554
LDB2
4
16,513,031


555
LDB2
4
16,515,486
556
LDB2
4
16,525,999


557
TLL1
4
167,073,589
558
PALLD
4
169,684,483


559
PALLD
4
169,690,892
560
PALLD
4
169,693,682


561
PALLD
4
169,702,565
562
PALLD
4
169,713,776


563
PALLD
4
169,721,943
564
PALLD
4
169,831,259


565
PALLD
4
169,831,979
566
PALLD
4
169,854,703


567
PALLD
4
169,855,143
568
PALLD
4
169,866,028


569
PALLD
4
169,971,032
570
ODZ3
4
183,473,721


571
ODZ3
4
183,476,755
572
ODZ3
4
183,478,510


573
ODZ3
4
183,917,862
574
ENPP6
4
185,269,255


575
ENPP6
4
185,283,835
576
ENPP6
4
185,287,394


577
ENPP6
4
185,287,415
578
ENPP6
4
185,300,448


579
ENPP6
4
185,314,095
580
CASP3
4
185,783,023


581
CASP3
4
185,791,294
582
SLIT2
4
19,872,156


583
SLIT2
4
20,162,402
584
SLIT2
4
20,172,206


585
SLIT2
4
20,177,664
586
SLIT2
4
20,194,981


587
SLIT2
4
20,202,844
588
PCDH7
4
30,441,417


589
KIAA1239
4
36,916,631
590
KIAA1239
4
37,005,415


591
KIAA1239
4
37,133,996
592
KIAA1239
4
37,134,494


593
KIAA1239
4
37,157,082
594
TBC1D1
4
37,815,251


595
UBE2K
4
39,386,342
596
UBE2K
4
39,464,805


597
UBE2K
4
39,494,511
598
LIMCH1
4
41,194,791


599
LIMCHI
4
41,213,350
600
LIMCHI
4
41,213,408


601
LIMCH1
4
41,215,951
602
LIMCHI
4
41,221,506


603
LIMCH1
4
41,221,779
604
LIMCH1
4
41,223,320


605
LIMCHI
4
41,308,688
606
LIMCHI
4
41,351,387


607
LIMCH1
4
41,354,243
608
LIMCH1
4
41,429,386


609
LOC389207
4
42,634,794
610
NPFFR2
4
73,115,321


611
NPFFR2
4
73,119,485
612
NPFFR2
4
73,122,182


613
NPFFR2
4
73,163,818
614
NPFFR2
4
73,236,822


615
NPFFR2
4
73,291,379
616
SCARB2
4
77,296,499


617
SHROOM3
4
77,855,667
618
SHROOM3
4
77,879,755


619
SCD5
4
83,785,141
620
SCD5
4
83,788,761


621
SCD5
4
83,794,856
622
SCD5
4
83,794,931


623
SCD5
4
83,845,049
624
HERC3
4
89,741,644


625
FAM13A1
4
89,915,913
626
FAM13A1
4
89,950,302


627
FAM13A1
4
89,950,932
628
SLC2A9
4
9,423,554


629
PDLIM5
4
95,558,356
630
SLC2A9
4
9,565,177


631
PDLIM5
4
95,660,615
632
PDLIM5
4
95,701,398


633
PDLIM5
4
95,701,843
634
PDLIM5
4
95,706,737


635
PDLIM5
4
95,747,196
636
PDLIM5
4
95,793,146


637
SLC2A9
4
9,605,988
638
SLC2A9
4
9,606,401


639
SLC2A9
4
9,606,899
640
SLC2A9
4
9,616,373


641
SLC2A9
4
9,633,401
642
SLC2A9
4
9,636,640


643
SLC2A9
4
9,665,474
644
FBXL17
5
107,441,485


645
FBXL17
5
107,546,460
646
FBXL17
5
107,612,678


647
FBXL17
5
107,624,474
648
FBXL17
5
107,704,154


649
FBXL17
5
107,773,275
650
FBXL17
5
107,810,930


651
FBXL17
5
107,812,906
652
PJA2
5
108,787,364


653
PJA2
5
108,817,419
654
KCNN2
5
113,739,288


655
KCNN2
5
113,751,518
656
KCNN2
5
113,763,996


657
KCNN2
5
113,784,704
658
KCNN2
5
113,790,709


659
KCNN2
5
113,858,701
660
SEMA6A
5
115,914,844


661
HSD17B4
5
118,817,237
662
HSD17B4
5
118,927,674


663
SNCAIP
5
121,678,639
664
SNCAIP
5
121,699,768


665
SNCAIP
5
121,757,816
666
SNCAIP
5
121,768,808


667
SNCAIP
5
121,796,570
668
SNX2
5
122,116,630


669
SNX2
5
122,174,518
670
SNX2
5
122,194,062


671
SNX2
5
122,201,930
672
SNX24
5
122,255,495


673
SNX24
5
122,273,273
674
SNX24
5
122,283,900


675
SNX24
5
122,363,934
676
ADAMTS19
5
129,005,631


677
VDAC1
5
133,405,061
678
TRPC7
5
135,649,997


679
TRPC7
5
135,695,682
680
TRPC7
5
135,705,746


681
TRPC7
5
135,712,132
682
TRPC7
5
135,724,949


683
DNAH5
5
13,795,858
684
DNAH5
5
13,822,974


685
DNAH5
5
13,832,743
686
DNAH5
5
13,841,886


687
DNAH5
5
13,842,420
688
DNAH5
5
13,947,894


689
DNAH5
5
13,953,345
690
DNAH5
5
13,955,220


691
DNAH5
5
13,957,400
692
DNAH5
5
14,034,968


693
GRIA1
5
152,893,595
694
GRIA1
5
152,916,373


695
GRIA1
5
152,931,785
696
GRIAI
5
152,952,893


697
GRIA1
5
152,956,518
698
GRIAI
5
153,075,197


699
GRIA1
5
153,100,457
700
GRIA1
5
153,112,499


701
GRIA1
5
153,127,393
702
GRIAI
5
153,150,567


703
GRIA1
5
153,159,007
704
ODZ2
5
167,085,900


705
MYO10
5
16,711,495
706
MYO10
5
16,711,524


707
ODZ2
5
167,162,881
708
ODZ2
5
167,191,250


709
ODZ2
5
167,391,524
710
ODZ2
5
167,556,686


711
ODZ2
5
167,610,277
712
ODZ2
5
167,634,619


713
MYO10
5
16,822,273
714
MYO10
5
16,838,077


715
BASP1
5
17,266,319
716
PLEKHG4B
5
208,367


717
PLEKHG4B
5
208,629
718
PLEKHG4B
5
208,831


719
PLEKHG4B
5
210,750
720
PLEKHG4B
5
226,200


721
CDH10
5
24,500,153
722
CDH10
5
24,533,855


723
SLC45A2
5
34,019,127
724
SLC45A2
5
34,025,275


725
C1QTNF3
5
34,071,366
726
C1QTNF3
5
34,074,611


727
C1QTNF3
5
34,083,721
728
C1QTNF3
5
34,087,314


729
SLC1A3
5
36,738,812
730
EGFLAM
5
38,269,319


731
EGFLAM
5
38,296,060
732
EGFLAM
5
38,320,906


733
AHRR
5
431,413
734
AHRR
5
465,694


735
AHRR
5
508,696
736
EXOC3
5
517,153


737
ITGA1
5
52,155,113
738
ITGA1
5
52,265,502


739
ITGA1
5
52,285,233
740
ITGA2
5
52,402,662


741
ITGA2
5
52,425,212
742
PDE4D
5
58,432,005


743
PDE4D
5
58,744,184
744
ELOVL7
5
60,101,698


745
ELOVL7
5
60,132,254
746
ELOVL7
5
60,152,637


747
ELOVL7
5
60,171,719
748
ELOVL7
5
60,201,944


749
TNPOI
5
72,174,208
750
TNPOI
5
72,182,236


751
TNPO1
5
72,217,160
752
FCHO2
5
72,384,028


753
CMYA5
5
79,029,508
754
CMYA5
5
79,058,467


755
CMYA5
5
79,070,418
756
THBS4
5
79,375,707


757
THBS4
5
79,376,918
758
THBS4
5
79,397,021


759
VCAN
5
82,818,286
760
VCAN
5
82,870,055


761
MEF2C
5
88,161,609
762
MEF2C
5
88,219,759


763
GPR98
5
89,976,245
764
GPR98
5
90,052,627


765
GPR98
5
90,109,033
766
GPR98
5
90,187,345


767
GPR98
5
90,203,767
768
SEMA5A
5
9,066,544


769
SEMA5A
5
9,107,741
770
SEMA5A
5
9,474,794


771
SEMA5A
5
9,477,130
772
SEMA5A
5
9,487,606


773
SEMA5A
5
9,495,994
774
CAST
5
96,088,713


775
SLC22A16
6
110,857,358
776
SLC22A16
6
110,914,475


777
HS3ST5
6
114,509,285
778
TRDN
6
123,728,987


779
TRDN
6
123,738,465
780
TRDN
6
123,743,637


781
TRDN
6
123,749,431
782
TRDN
6
123,753,816


783
TRDN
6
123,766,181
784
TRDN
6
123,791,627


785
TRDN
6
123,871,263
786
TRDN
6
123,877,575


787
TRDN
6
123,903,977
788
TRDN
6
123,931,045


789
TRDN
6
124,006,657
790
TRDN
6
124,017,012


791
NKAIN2
6
124,481,807
792
NKAIN2
6
124,747,202


793
NKAIN2
6
124,828,559
794
NKAIN2
6
124,867,074


795
NKAIN2
6
124,953,233
796
NKAIN2
6
124,962,839


797
NKAIN2
6
124,982,795
798
NKAIN2
6
124,986,819


799
NKAIN2
6
124,987,301
800
NKAIN2
6
125,020,491


801
PHACTR1
6
12,858,919
802
PHACTR1
6
13,276,521


803
PHACTR1
6
13,286,048
804
PHACTR1
6
13,297,254


805
EYA4
6
133,636,045
806
EYA4
6
133,643,088


807
EYA4
6
133,651,991
808
EYA4
6
133,668,941


809
PDE7B
6
136,218,421
810
PDE7B
6
136,244,527


811
PDE7B
6
136,375,641
812
PLAGL1
6
144,319,261


813
PLAGL1
6
144,354,821
814
PLAGL1
6
144,355,380


815
UTRN
6
144,651,202
816
UTRN
6
144,657,997


817
UTRN
6
145,021,020
818
SYNE1
6
152,505,595


819
SYNE1
6
152,511,829
820
JARID2
6
15,608,978


821
SLC22A3
6
160,771,756
822
PARK2
6
161,938,126


823
PARK2
6
161,960,395
824
PARK2
6
162,001,753


825
PARK2
6
162,026,087
826
PARK2
6
162,201,362


827
PARK2
6
162,204,134
828
PARK2
6
162,725,125


829
PARK2
6
162,877,565
830
PARK2
6
162,891,538


831
PARK2
6
162,899,137
832
PARK2
6
162,914,629


833
PARK2
6
162,959,624
834
PACRG
6
163,515,155


835
PACRG
6
163,523,252
836
PDE10A
6
165,674,966


837
PDE10A
6
165,835,911
838
PDE10A
6
165,868,541


839
ATXN1
6
16,595,385
840
ATXN1
6
16,762,002


841
ATXN1
6
16,767,074
842
ATXN1
6
16,799,821


843
SLC17A4
6
25,852,810
844
SLC17A4
6
25,887,371


845
SLC17A1
6
25,909,950
846
SLC17A4
6
25,917,888


847
SLC17A1
6
25,950,182
848
SLC17A3
6
25,972,877


849
SLC17A2
6
26,042,503
850
BTN3A1
6
26,506,534


851
BTN3A1
6
26,513,969
852
BTN3A1
6
26,525,105


853
BTN3A1
6
26,528,031
854
BTN2A3
6
26,534,466


855
BTN3A3
6
26,553,839
856
BTNL2
6
32,462,406


857
BTNL2
6
32,463,841
858
BTNL2
6
32,471,794


859
SLC22A23
6
3,395,265
860
LRFN2
6
40,526,934


861
LRFN2
6
40,535,717
862
LRFN2
6
40,585,166


863
LRFN2
6
40,598,884
864
PPP2R5D
6
43,095,976


865
KLC4
6
43,139,233
866
ELOVL5
6
53,298,209


867
ELOVL5
6
53,350,763
868
ELOVL5
6
53,372,444


869
RIMS1
6
72,772,376
870
RIMS1
6
72,784,876


871
RIMS1
6
72,860,627
872
RIMS1
6
72,866,707


873
RIMS1
6
72,939,135
874
RIMS1
6
72,963,198


875
RIMS1
6
72,974,869
876
RIMS1
6
72,977,664


877
RIMS1
6
72,982,413
878
RIMS1
6
73,031,069


879
HTR1B
6
78,228,979
880
KLHL32
6
97,480,306


881
KLHL32
6
97,589,639
882
KLHL32
6
97,595,870


883
KLHL32
6
97,673,659
884
CUX1
7
100,785,884


885
CUX1
7
101,306,594
886
CUX1
7
101,694,544


887
CADPS2
7
122,055,480
888
CADPS2
7
122,066,038


889
CADPS2
7
122,074,175
890
CADPS2
7
122,090,557


891
CADPS2
7
122,093,518
892
CADPS2
7
122,329,881


893
GRM8
7
125,808,541
894
GRM8
7
125,837,771


895
GRM8
7
125,879,584
896
GRM8
7
125,888,427


897
GAMS
7
125,912,289
898
GRM8
7
126,156,034


899
GRM8
7
126,225,935
900
GRM8
7
126,234,800


901
GRM8
7
126,299,256
902
GRM8
7
126,521,407


903
GRM8
7
126,552,824
904
GRM8
7
126,699,931


905
EXOC4
7
132,456,559
906
EXOC4
7
132,754,129


907
EXOC4
7
132,789,020
908
EXOC4
7
132,895,544


909
EXOC4
7
132,917,865
910
EXOC4
7
132,938,673


911
EXOC4
7
133,236,629
912
EXOC4
7
133,265,250


913
EXOC4
7
133,352,637
914
EXOC4
7
133,378,037


915
DGKI
7
136,730,489
916
DGKI
7
136,735,790


917
CREB3L2
7
137,269,815
918
CREB3L2
7
137,275,099


919
CREB3L2
7
137,278,186
920
TBXAS1
7
139,135,304


921
TBXAS1
7
139,175,131
922
TBXAS1
7
139,184,991


923
TBXAS1
7
139,311,144
924
ETV1
7
13,945,334


925
CNTNAP2
7
145,430,948
926
CNTNAP2
7
145,431,076


927
CNTNAP2
7
145,688,576
928
CNTNAP2
7
145,710,838


929
CNTNAP2
7
145,724,542
930
CNTNAP2
7
145,906,353


931
CNTNAP2
7
146,782,515
932
CNTNAP2
7
146,786,412


933
CNTNAP2
7
146,788,354
934
CNTNAP2
7
146,800,067


935
CNTNAP2
7
147,069,599
936
CNTNAP2
7
147,102,055


937
CNTNAP2
7
147,136,686
938
CNTNAP2
7
147,669,284


939
CNTNAP2
7
147,712,266
940
PTPRN2
7
157,024,663


941
PTPRN2
7
157,175,770
942
PTPRN2
7
157,662,662


943
PTPRN2
7
157,973,350
944
STK31
7
23,760,407


945
STK31
7
23,799,768
946
SKAP2
7
26,795,178


947
SKAP2
7
26,827,158
948
SKAP2
7
26,827,213


949
SKAP2
7
26,830,698
950
SKAP2
7
26,858,965


951
CREB5
7
28,286,559
952
CREB5
7
28,798,822


953
CREB5
7
28,812,569
954
CREB5
7
28,818,987


955
CREB5
7
28,870,041
956
CREB5
7
28,906,935


957
CARD11
7
2,928,819
958
CHN2
7
29,483,175


959
CHN2
7
29,486,454
960
CHN2
7
29,560,895


961
SCRN1
7
29,926,987
962
SCRNI
7
29,929,459


963
SCRN1
7
30,052,432
964
ZNRF2
7
30,379,551


965
CRI R2
7
30,676,000
966
CRHR2
7
30,775,386


967
FLJ22374
7
30,787,631
968
FLJ22374
7
30,803,801


969
FLJ22374
7
30,813,272
970
FLJ22374
7
30,832,290


971
FLJ22374
7
30,842,957
972
FLJ22374
7
30,843,167


973
PDE1C
7
31,841,400
974
PDE1C
7
32,064,508


975
PDE1C
7
32,141,959
976
BMPER
7
33,942,093


977
BMPER
7
33,994,557
978
BMPER
7
34,050,872


979
BMPER
7
34,056,348
980
BMPER
7
34,077,080


981
BMPER
7
34,077,746
982
BMPER
7
34,107,862


983
VPS41
7
38,759,185
984
VPS41
7
38,859,847


985
VPS41
7
38,882,602
986
VPS41
7
38,936,691


987
CDC2L5
7
40,056,457
988
CDC2L5
7
40,083,623


989
CDC2L5
7
40,124,213
990
CDC2L5
7
40,125,052


991
SDK1
7
4,140,139
992
SDK1
7
4,230,185


993
SDKI
7
4,272,360
994
IGFBP3
7
45,916,971


995
IGFBP3
7
45,990,559
996
IGFBP3
7
46,061,993


997
ABCA13
7
48,380,796
998
ABCA13
7
48,399,261


999
ABCA13
7
48,425,013
1000
ABCA13
7
48,425,630


1001
ABCA13
7
48,656,578
1002
ABCA13
7
48,681,043


1003
GRB10
7
50,707,082
1004
GRB10
7
50,727,714


1005
WBSCR17
7
69,982,663
1006
WBSCR17
7
70,020,032


1007
WBSCRI7
7
70,024,662
1008
WBSCR17
7
70,327,601


1009
WBSCRI7
7
70,328,803
1010
WBSCR17
7
70,508,901


1011
LIMK1
7
73,155,050
1012
LIMK1
7
73,189,576


1013
LIMK1
7
73,201,992
1014
GTF2IRD1
7
73,552,324


1015
HIP1
7
74,641,558
1016
HIP1
7
75,137,795


1017
HIP1
7
75,149,973
1018
HIP1
7
75,189,895


1019
MAGI2
7
77,497,177
1020
MAGI2
7
77,707,944


1021
MA012
7
78,081,016
1022
MAGI2
7
78,087,129


1023
MAGI2
7
78,091,049
1024
MAGI2
7
78,331,358


1025
MAGI2
7
78,639,527
1026
MAGI2
7
78,753,565


1027
MAGI2
7
78,779,395
1028
MAGI2
7
78,817,962


1029
MAGI2
7
78,865,894
1030
MAGI2
7
78,873,419


1031
MAGI2
7
78,902,124
1032
CACNA2D1
7
81,000,419


1033
CACNA2D1
7
81,501,211
1034
CACNA2D1
7
81,551,628


1035
PCLO
7
81,734,489
1036
CACNA2D1
7
81,827,271


1037
CACNA2D1
7
81,829,947
1038
CACNA2D1
7
81,841,829


1039
CACNA2D1
7
81,844,366
1040
CACNA2D1
7
81,846,503


1041
PCLO
7
82,252,869
1042
PCLO
7
82,287,971


1043
PCLO
7
82,291,644
1044
PCLO
7
82,292,608


1045
PCLO
7
82,317,658
1046
PCLO
7
82,341,345


1047
PCLO
7
82,341,378
1048
PCLO
7
82,358,102


1049
PCLO
7
82,391,885
1050
PCLO
7
82,562,475


1051
PCLO
7
82,567,345
1052
PCLO
7
82,573,554


1053
PCLO
7
82,573,594
1054
PCLO
7
82,636,908


1055
PCLO
7
82,659,120
1056
SEMA3E
7
82,895,964


1057
SEMA3E
7
82,901,024
1058
SEMA3A
7
82,965,762


1059
SEMA3E
7
83,047,248
1060
SEMA3E
7
83,061,152


1061
SEMA3E
7
83,125,543
1062
SEMA3A
7
83,451,819


1063
SEMA3A
7
83,559,228
1064
SEMA3A
7
83,559,858


1065
SEMA3A
7
83,564,904
1066
SEMA3A
7
83,565,919


1067
SEMA3A
7
83,568,098
1068
SEMA3A
7
83,571,382


1069
SEMA3A
7
83,572,529
1070
SEMA3A
7
83,573,829


1071
NXPH1
7
8,662,332
1072
ABCB4
7
86,868,839


1073
ABCB4
7
86,883,520
1074
ABCB4
7
86,897,339


1075
ADAM22
7
87,086,253
1076
ADAM22
7
87,441,679


1077
ADAM22
7
87,471,187
1078
ADAM22
7
87,471,440


1079
ADAM22
7
87,554,236
1080
ADAM22
7
87,557,024


1081
ADAM22
7
87,579,450
1082
ADAM22
7
87,606,110


1083
ADAM22
7
87,613,210
1084
ADAM22
7
87,632,643


1085
ADAM22
7
87,634,202
1086
NXPH1
7
8,780,133


1087
PPP1R9A
7
94,747,598
1088
PPP1R9A
7
94,772,391


1089
PON1
7
94,776,112
1090
PON1
7
94,776,193


1091
PON1
7
94,784,507
1092
DYNC1I1
7
95,385,967


1093
DYNC1I1
7
95,451,958
1094
GRHL2
8
102,577,101


1095
GRHL2
8
102,580,894
1096
GRHL2
8
102,718,857


1097
GRHL2
8
102,740,588
1098
NCALD
8
102,769,504


1099
NCALD
8
102,769,812
1100
NCALD
8
102,777,547


1101
NCALD
8
102,812,988
1102
ZFPM2
8
106,505,157


1103
ZFPM2
8
106,521,287
1104
ZFPM2
8
106,530,047


1105
ZFPM2
8
106,567,598
1106
ZFPM2
8
106,614,970


1107
ZFPM2
8
106,794,185
1108
ZFPM2
8
106,803,045


1109
ZFPM2
8
106,828,892
1110
ZFPM2
8
106,841,629


1111
CSMD3
8
113,479,682
1112
CSMD3
8
113,554,821


1113
CSMD3
8
113,568,517
1114
CSMD3
8
113,570,484


1115
CSMD3
8
114,319,937
1116
CSMD3
8
114,432,523


1117
CSMD3
8
114,441,419
1118
CSMD3
8
114,475,512


1119
SAMD12
8
119,514,024
1120
SAMD12
8
119,530,374


1121
SAMD12
8
119,532,252
1122
SAMD12
8
119,536,976


1123
SAMD12
8
119,671,788
1124
FBXO32
8
124,567,915


1125
FBXO32
8
124,583,159
1126
FER1L6
8
124,996,892


1127
FER1L6
8
125,011,048
1128
FER1L6
8
125,014,271


1129
FER1L6
8
125,014,506
1130
FER1L6
8
125,020,334


1131
FER1L6
8
125,032,627
1132
FER1L6
8
125,053,616


1133
FER1L6
8
125,102,576
1134
FER1L6
8
125,104,714


1135
FER1L6
8
125,108,933
1136
FER1L6
8
125,218,759


1137
MTSS1
8
125,649,171
1138
MTSS1
8
125,651,280


1139
DLC1
8
13,014,125
1140
DDEF1
8
131,407,018


1141
ADCY8
8
131,972,316
1142
ADCY8
8
131,983,404


1143
ADCY8
8
131,985,500
1144
ADCY8
8
131,997,583


1145
KCNQ3
8
133,208,937
1146
KCNQ3
8
133,473,613


1147
ST3GAL1
8
134,609,061
1148
ST3GAL1
8
134,610,724


1149
ST3GAL1
8
134,664,388
1150
COL22A1
8
139,668,834


1151
COL22A1
8
139,892,385
1152
COL22A1
8
139,901,545


1153
SGCZ
8
14,059,709
1154
SGCZ
8
14,594,583


1155
SGCZ
8
14,876,643
1156
SGCZ
8
14,898,152


1157
SLC7A2
8
17,431,231
1158
SLC7A2
8
17,431,383


1159
SLC7A2
8
17,480,455
1160
PSD3
8
18,708,574


1161
PSD3
8
18,709,420
1162
PSD3
8
18,732,409


1163
PSD3
8
18,737,733
1164
PSD3
8
18,749,712


1165
PSD3
8
18,757,428
1166
PSD3
8
18,765,584


1167
PSD3
8
18,773,018
1168
PSD3
8
18,819,182


1169
PSD3
8
18,953,685
1170
ATP6V1B2
8
20,135,799


1171
GFRA2
8
21,616,512
1172
PEBP4
8
22,632,507


1173
ENTPD4
8
23,353,499
1174
SLC25A37
8
23,453,211


1175
SLC25A37
8
23,471,600
1176
CSMD1
8
2,849,233


1177
CSMD1
8
2,864,416
1178
CSMD1
8
2,958,438


1179
CSMD1
8
3,206,762
1180
CSMD1
8
3,209,023


1181
CSMD1
8
3,211,642
1182
CSMD1
8
3,216,613


1183
CSMD1
8
3,245,103
1184
CSMD1
8
3,275,090


1185
CSMD1
8
3,292,328
1186
UNC5D
8
35,516,694


1187
UNC5D
8
35,586,829
1188
SFRP1
8
41,244,318


1189
SFRP1
8
41,247,567
1190
SFRP1
8
41,247,867


1191
SFRP1
8
41,262,183
1192
SFRP1
8
41,284,951


1193
SNTG1
8
50,981,354
1194
SNTG1
8
51,028,383


1195
SNTG1
8
51,082,766
1196
SNTG1
8
51,127,991


1197
MCPH1
8
6,266,787
1198
MCPH1
8
6,290,817


1199
MCPH1
8
6,290,919
1200
MCPH1
8
6,297,826


1201
MCPH1
8
6,306,930
1202
MCPH1
8
6,307,055


1203
MCPH1
8
6,307,171
1204
MCPH1
8
6,313,383


1205
MCPH1
8
6,316,969
1206
NKAIN3
8
63,450,524


1207
NKAIN3
8
63,573,341
1208
MCPH1
8
6,357,338


1209
MCPH1
8
6,362,452
1210
NKAIN3
8
63,670,367


1211
NKAIN3
8
63,897,057
1212
NKAIN3
8
64,008,938


1213
NKAIN3
8
64,056,708
1214
NKAIN3
8
64,084,956


1215
MCPH1
8
6,460,526
1216
DEPDC2
8
69,098,456


1217
DEPDC2
8
69,098,725
1218
DEPDC2
8
69,121,712


1219
DEPDC2
8
69,144,533
1220
DEPDC2
8
69,156,370


1221
DEPDC2
8
69,207,400
1222
DEPDC2
8
69,209,296


1223
DEPDC2
8
69,301,731
1224
DEPDC2
8
69,314,054


1225
KCNB2
8
73,614,029
1226
KCNB2
8
73,618,324


1227
KCNB2
8
73,754,111
1228
KCNB2
8
73,756,664


1229
KCNB2
8
73,762,984
1230
KCNB2
8
73,776,211


1231
KCNB2
8
73,783,806
1232
KCNB2
8
73,813,319


1233
MMP16
8
89,061,627
1234
MMP16
8
89,120,413


1235
MMP16
8
89,148,139
1236
MMP16
8
89,337,659


1237
MMP16
8
89,367,315
1238
MMP16
8
89,392,120


1239
MMP16
8
89,413,738
1240
MMP16
8
89,414,303


1241
MMP16
8
89,421,430
1242
GABBR2
9
100,094,975


1243
GABBR2
9
100,095,943
1244
GABBR2
9
100,419,601


1245
GABBR2
9
100,469,409
1246
RP11-35N6.1
9
102,472,272


1247
FER1L6
9
103,382,443
1248
GRIN3A
9
103,473,056


1249
GRIN3A
9
103,521,201
1250
FKTN
9
107,409,195


1251
FKTN
9
107,449,221
1252
FKTN
9
107,455,377


1253
SVEP1
9
112,152,393
1254
SVEP1
9
112,166,117


1255
SVEP1
9
112,167,878
1256
CDK5RAP2
9
122,209,539


1257
CDK5RAP2
9
122,337,266
1258
CDK5RAP2
9
122,362,134


1259
CDK5RAP2
9
122,370,634
1260
STOM
9
123,165,341


1261
DAB2IP
9
123,691,611
1262
RALGPS1
9
128,698,499


1263
RALGPS1
9
128,769,224
1264
RALGPS1
9
128,789,061


1265
RALGPS1
9
128,809,594
1266
RALGPS1
9
128,902,817


1267
SLC25A25
9
129,886,889
1268
SLC25A25
9
129,899,153


1269
FREQ
9
131,997,035
1270
EXOSC2
9
132,588,852


1271
ABL1
9
132,715,588
1272
ABL1
9
132,721,005


1273
ABL1
9
132,722,573
1274
ABL1
9
132,723,896


1275
TSC1
9
134,811,193
1276
TSC1
9
134,812,111


1277
VAV2
9
135,795,115
1278
OLFM1
9
137,113,249


1279
OLFM1
9
137,127,054
1280
INPP5E
9
138,461,433


1281
NOTCH1
9
138,555,218
1282
CACNA1B
9
140,072,737


1283
CACNA1B
9
140,075,368
1284
ASAH3L
9
19,460,804


1285
KIAA1797
9
20,673,404
1286
KIAA1797
9
20,678,117


1287
KIAA1797
9
20,732,210
1288
KIAA1797
9
20,753,840


1289
KIAA1797
9
20,754,870
1290
KIAA1797
9
20,804,142


1291
KIAA1797
9
20,898,513
1292
KIAA1797
9
20,921,349


1293
KIAA1797
9
20,935,372
1294
KIAA1797
9
20,943,233


1295
KIAA1797
9
20,943,335
1296
KIAA1797
9
20,943,750


1297
KIAA1797
9
20,951,906
1298
KIAA1797
9
20,977,703


1299
KIAA1797
9
20,978,426
1300
KIAA1797
9
20,986,709


1301
SMARCA2
9
2,120,828
1302
SMARCA2
9
2,120,917


1303
SMARCA2
9
2,121,990
1304
SMARCA2
9
2,178,383


1305
IFT74
9
26,999,100
1306
TEK
9
27,129,817


1307
TEK
9
27,175,101
1308
TEK
9
27,210,066


1309
TEK
9
27,224,049
1310
SLC1A1
9
4,550,348


1311
SLC1A1
9
4,552,472
1312
PIP5K1B
9
70,507,948


1313
PIP5K1B
9
70,552,216
1314
PIP5K1B
9
70,672,108


1315
PIP5K1B
9
70,687,329
1316
PIP5K1B
9
70,691,508


1317
PIP5K1B
9
70,703,782
1318
APBA1
9
71,324,196


1319
TRPM3
9
72,346,211
1320
TRPM3
9
72,637,875


1321
TRPM3
9
72,648,924
1322
TRPM3
9
72,649,911


1323
TRPM3
9
72,673,741
1324
TMC1
9
74,397,486


1325
TMC1
9
74,443,712
1326
TMC1
9
74,579,921


1327
PCSK5
9
77,687,086
1328
PCSK5
9
77,896,771


1329
PCSK5
9
77,912,756
1330
GNAQ
9
79,595,252


1331
GNAQ
9
79,703,143
1332
GNAQ
9
79,908,612


1333
PTPRD
9
8,372,966
1334
PTPRD
9
8,390,681


1335
NTRK2
9
86,472,851
1336
NTRK2
9
86,479,077


1337
NTRK2
9
86,599,187
1338
DAPK1
9
89,448,453


1339
DAPK1
9
89,452,483
1340
DAPK1
9
89,511,843


1341
SORCS3
10
106,371,034
1342
SORCS3
10
106,592,352


1343
SORCS3
10
106,614,338
1344
SORCS3
10
106,622,111


1345
SORCS3
10
106,622,468
1346
SORCS3
10
106,625,786


1347
SORCS3
10
106,777,753
1348
SORCS3
10
106,782,237


1349
SORCS3
10
106,897,228
1350
SORCS3
10
106,906,037


1351
SORCS3
10
106,906,641
1352
SORCS3
10
107,025,958


1353
CUGBP2
10
11,277,934
1354
VTI1A
10
114,226,855


1355
VTI1A
10
114,228,361
1356
VTI1A
10
114,424,611


1357
VTI1A
10
114,458,106
1358
VTI1A
10
114,458,428


1359
VTI1A
10
114,506,363
1360
VTI1A
10
114,508,308


1361
HSPA12A
10
118,432,901
1362
HSPA12A
10
118,469,221


1363
ATE1
10
123,432,831
1364
ATE1
10
123,450,896


1365
ATEI
10
123,453,723
1366
ATE1
10
123,644,015


1367
ATE1
10
123,651,712
1368
ATEI
10
123,663,196


1369
ATE1
10
123,669,674
1370
CTBP2
10
126,677,518


1371
ARMC3
10
23,277,574
1372
ARMC3
10
23,289,115


1373
ARMC3
10
23,314,154
1374
ARMC3
10
23,318,053


1375
ARMC3
10
23,337,258
1376
ARMC3
10
23,364,367


1377
ARMC3
10
23,372,952
1378
ARHGAP21
10
25,046,553


1379
MYO3A
10
26,398,660
1380
MYO3A
10
26,552,050


1381
PITRM1
10
3,166,363
1382
PITRM1
10
3,169,968


1383
PITRM1
10
3,179,380
1384
PITRM1
10
3,192,065


1385
PITRM1
10
3,213,179
1386
SLC16A9
10
61,024,452


1387
SLC16A9
10
61,082,341
1388
SLC16A9
10
61,084,017


1389
SLC16A9
10
61,120,938
1390
SLC16A9
10
61,122,758


1391
PRKCQ
10
6,567,350
1392
PRKCQ
10
7,152,082


1393
CDH23
10
72,997,429
1394
CDH23
10
73,104,912


1395
CDH23
10
73,126,384
1396
KCNMA1
10
78,319,405


1397
KCNMA1
10
78,319,936
1398
KCNMA1
10
78,320,267


1399
KCNMA1
10
78,324,802
1400
KCNMA1
10
78,348,173


1401
KCNMA1
10
78,626,486
1402
KCNMA1
10
78,738,970


1403
KCNMA1
10
78,757,625
1404
KCNMAI
10
78,799,763


1405
KCNMA1
10
78,817,839
1406
KCNMA1
10
78,872,456


1407
KCNMA1
10
79,094,637
1408
NRG3
10
84,068,972


1409
NRG3
10
84,070,208
1410
NRG3
10
84,604,364


1411
NRG3
10
84,613,706
1412
NRG3
10
84,616,939


1413
SORBS1
10
97,061,507
1414
SORBS1
10
97,122,546


1415
SORBS1
10
97,122,783
1416
SORBS1
10
97,126,192


1417
SORBS1
10
97,127,095
1418
SORBS1
10
97,216,419


1419
ELMOD1
11
107,077,060
1420
GALNTL4
11
11,246,740


1421
GALNTL4
11
11,497,136
1422
MICAL2
11
12,139,036


1423
MICAL2
11
12,142,872
1424
MICAL2
11
12,149,199


1425
MICAL2
11
12,155,884
1426
MICAL2
11
12,175,779


1427
MICAL2
11
12,222,118
1428
OPCML
11
131,718,194


1429
OPCML
11
132,078,600
1430
ARNTL
11
13,212,114


1431
ARNTL
11
13,212,547
1432
OPCML
11
132,803,817


1433
OPCML
11
132,884,694
1434
OPCML
11
132,895,944


1435
SPON1
11
13,882,655
1436
SPON1
11
13,922,920


1437
SPON1
11
13,994,054
1438
SPON1
11
14,008,775


1439
SPON1
11
14,014,762
1440
SPON1
11
14,023,125


1441
SPON1
11
14,034,087
1442
SPON1
11
14,070,335


1443
SPON1
11
14,075,677
1444
SPON1
11
14,215,231


1445
INSC
11
15,138,272
1446
KCNA4
11
29,964,590


1447
KCNA4
11
29,984,859
1448
STIM1
11
3,847,536


1449
STIM1
11
3,867,621
1450
STIM1
11
3,927,655


1451
STIM1
11
4,033,624
1452
TRIM21
11
4,371,449


1453
C11ORF49
11
47,089,300
1454
81.99 mb
11
81,921,684


1455
DLG2
11
82,719,582
1456
DLG2
11
82,720,706


1457
DLG2
11
82,743,548
1458
DLG2
11
82,843,293


1459
DLG2
11
82,856,041
1460
DLG2
11
82,974,099


1461
DLG2
11
82,982,760
1462
DLG2
11
83,366,230


1463
DLG2
11
83,418,483
1464
DLG2
11
83,444,686


1465
DLG2
11
83,457,074
1466
DLG2
11
84,138,503


1467
DLG2
11
84,147,518
1468
DLG2
11
84,153,124


1469
DLG2
11
84,214,566
1470
DLG2
11
84,251,688


1471
DLG2
11
84,251,805
1472
DLG2
11
84,261,681


1473
DLG2
11
84,273,766
1474
DLG2
11
84,283,321


1475
DLG2
11
84,283,477
1476
DLG2
11
84,425,370


1477
CHST11
12
103,435,376
1478
CHST11
12
103,448,913


1479
CHST11
12
103,599,400
1480
ATXN2
12
110,547,258


1481
PLA2GIB
12
119,254,040
1482
LOC729025
12
16,298,403


1483
LOC729025
12
16,302,981
1484
PIK3C2G
12
18,305,520


1485
PIK3C2G
12
18,356,504
1486
PIK3C2G
12
18,426,133


1487
PIK3C2G
12
18,576,788
1488
PIK3C2G
12
18,701,315


1489
ITPR2
12
26,366,134
1490
ITPR2
12
26,382,742


1491
TMEM16B
12
5,505,585
1492
LRP1
12
55,821,533


1493
TMEM16B
12
5,690,939
1494
TMEM16B
12
5,712,102


1495
TMEM16B
12
5,755,581
1496
TMEM16B
12
5,760,697


1497
TMEM16B
12
5,786,169
1498
TMEM16B
12
5,794,409


1499
TMEM16B
12
5,901,003
1500
CNOT2
12
68,831,198


1501
CNOT2
12
69,026,461
1502
KCNC2
12
73,877,027


1503
KCNC2
12
73,886,479
1504
KCNC2
12
73,898,155


1505
KCNC2
12
73,944,836
1506
NAV3
12
76,718,256


1507
NAV3
12
76,748,290
1508
NAV3
12
76,793,282


1509
NAV3
12
76,798,556
1510
NAV3
12
76,824,819


1511
NAV3
12
76,839,838
1512
NAV3
12
76,845,308


1513
NAV3
12
76,854,382
1514
NAV3
12
76,862,517


1515
NAV3
12
76,862,929
1516
NAV3
12
76,893,657


1517
NAV3
12
76,913,545
1518
NAV3
12
76,922,312


1519
NAV3
12
77,013,958
1520
NALCN
13
100,607,424


1521
NALCN
13
100,611,279
1522
NALCN
13
100,618,459


1523
NALCN
13
100,631,451
1524
NALCN
13
100,633,744


1525
NALCN
13
100,638,349
1526
NALCN
13
100,645,729


1527
NALCN
13
100,686,017
1528
NALCN
13
100,689,460


1529
NALCN
13
100,803,215
1530
ITGBL1
13
100,951,158


1531
ITGBL1
13
101,018,194
1532
ITGBL1
13
101,066,640


1533
ITGBL1
13
101,070,551
1534
ITGBL1
13
101,071,354


1535
ITGBL1
13
101,088,453
1536
ITGBL1
13
101,144,171


1537
FGF14
13
101,180,363
1538
FGF14
13
101,217,477


1539
FGF14
13
101,224,288
1540
FGF14
13
101,237,184


1541
FGF14
13
101,904,537
1542
MTIF3
13
26,979,535


1543
N4BP2L2
13
31,899,297
1544
N4BP2L2
13
31,934,759


1545
N4BP2L2
13
31,953,620
1546
N4BP2L2
13
32,021,516


1547
NBEA
13
34,773,125
1548
NBEA
13
34,848,999


1549
NBEA
13
35,142,667
1550
NBEA
13
35,170,524


1551
NBEA
13
35,171,922
1552
TRPC4
13
37,131,370


1553
TRPC4
13
37,131,795
1554
TRPC4
13
37,134,885


1555
TRPC4
13
37,134,956
1556
TRPC4
13
37,135,147


1557
TRPC4
13
37,148,211
1558
TRPC4
13
37,201,686


1559
TRPC4
13
37,203,414
1560
TRPC4
13
37,259,744


1561
TRPC4
13
37,316,370
1562
TRPC4
13
37,343,196


1563
TRPC4
13
37,343,288
1564
TRPC4
13
37,354,793


1565
FNDC3A
13
48,484,019
1566
FNDC3A
13
48,526,907


1567
FNDC3A
13
48,569,216
1568
FNDC3A
13
48,609,971


1569
KPNA3
13
49,294,756
1570
PCDH17
13
57,113,277


1571
PCDH17
13
57,133,204
1572
SLAIN1
13
77,130,842


1573
SLAIN1
13
77,151,328
1574
SLAIN1
13
77,192,452


1575
SLAIN1
13
77,211,551
1576
SLAIN1
13
77,232,218


1577
SLAIN1
13
77,273,814
1578
SLAIN1
13
77,290,759


1579
GPC5
13
90,547,957
1580
GPC5
13
90,931,610


1581
GPC5
13
91,966,983
1582
GPC5
13
92,117,714


1583
GPC5
13
92,121,270
1584
GPC5
13
92,275,844


1585
GPC5
13
92,302,532
1586
GPC5
13
92,332,949


1587
GPC5
13
92,347,342
1588
GPC6
13
92,775,697


1589
GPC6
13
92,807,479
1590
GPC6
13
93,185,878


1591
GPC6
13
93,196,895
1592
GPC6
13
93,196,981


1593
GPC6
13
93,204,846
1594
GPC6
13
93,497,436


1595
GPC6
13
93,851,561
1596
GPC6
13
93,863,575


1597
NPAS3
14
32,590,670
1598
NPAS3
14
32,661,665


1599
NPAS3
14
32,777,738
1600
NPAS3
14
32,782,805


1601
NPAS3
14
32,983,731
1602
NPAS3
14
33,099,951


1603
NPAS3
14
33,099,995
1604
NPAS3
14
33,192,848


1605
NPAS3
14
33,194,275
1606
NPAS3
14
33,206,451


1607
NPAS3
14
33,207,004
1608
SLC25A21
14
36,242,267


1609
SLC25A21
14
36,419,536
1610
LRFN5
14
41,384,489


1611
LRFN5
14
41,391,684
1612
GNG2
14
51,400,583


1613
GNG2
14
51,409,101
1614
GNG2
14
51,428,644


1615
GNG2
14
51,520,930
1616
SAMD4A
14
54,112,365


1617
SAMD4A
14
54,314,899
1618
SAMD4A
14
54,319,095


1619
SAMD4A
14
54,335,321
1620
PPP2R5E
14
62,858,991


1621
PPP2R5E
14
63,091,961
1622
PPP2R5E
14
63,099,534


1623
PPP2R5E
14
63,213,578
1624
RGS6
14
71,479,105


1625
RGS6
14
71,524,688
1626
RGS6
14
71,532,447


1627
RGS6
14
71,538,158
1628
RGS6
14
71,730,259


1629
RGS6
14
71,789,160
1630
RGS6
14
71,870,813


1631
RGS6
14
71,979,491
1632
KCNK10
14
87,843,799


1633
KCNK10
14
87,887,777
1634
RPS6KA5
14
90,431,677


1635
RPS6KA5
14
90,501,524
1636
RPS6KA5
14
90,536,260


1637
RPS6KA5
14
90,572,871
1638
RPS6KA5
14
90,592,117


1639
RPS6KA5
14
90,600,783
1640
RPS6KA5
14
90,600,927


1641
RPS6KA5
14
90,616,889
1642
CCDC88C
14
90,910,934


1643
CCDC88C
14
90,916,433
1644
CCDC88C
14
90,918,598


1645
CCDC88C
14
90,919,949
1646
CCDC88C
14
90,920,049


1647
CCDC88C
14
90,926,910
1648
BCL11B
14
98,713,688


1649
BCL11B
14
98,742,719
1650
BCL11B
14
98,816,027


1651
ATP10A
15
23,478,440
1652
ATP10A
15
23,496,935


1653
RYR3
15
31,550,764
1654
RYR3
15
31,564,997


1655
RYR3
15
31,695,608
1656
RYR3
15
31,744,674


1657
RYR3
15
31,745,083
1658
RYR3
15
31,814,492


1659
RYR3
15
31,815,285
1660
RYR3
15
31,899,901


1661
C15ORF41
15
34,691,218
1662
C15ORF41
15
34,707,884


1663
C15ORF41
15
34,751,160
1664
C15ORF41
15
34,755,325


1665
C15ORF41
15
34,780,489
1666
C15ORF41
15
34,793,623


1667
C15ORF41
15
34,833,829
1668
RASGRPI
15
36,607,181


1669
PLA2G4D
15
40,137,329
1670
GLDN
15
49,440,552


1671
GLDN
15
49,477,064
1672
GLDN
15
49,481,784


1673
CGNL1
15
55,403,598
1674
CGNL1
15
55,518,865


1675
CGNL1
15
55,521,306
1676
CGNL1
15
55,595,257


1677
CGNL1
15
55,623,195
1678
CGNL1
15
55,623,569


1679
RORA
15
58,605,378
1680
RORA
15
58,680,723


1681
CLK3
15
72,697,052
1682
TBC1D2B
15
76,096,608


1683
TBCID2B
15
76,098,398
1684
TBC1D2B
15
76,121,710


1685
TBCID2B
15
76,150,830
1686
ARNT2
15
78,539,124


1687
ARNT2
15
78,700,178
1688
ARNT2
15
78,703,747


1689
ARNT2
15
78,704,322
1690
ARNT2
15
78,718,605


1691
ARNT2
15
78,719,745
1692
SH3GL3
15
81,818,542


1693
PCSK6
15
99,842,741
1694
TMC5
16
19,254,444


1695
GDE1
16
19,447,359
1696
EEF2K
16
22,114,775


1697
KIFC3
16
56,376,436
1698
KIFC3
16
56,379,768


1699
A2BP1
16
6,527,248
1700
A2BP1
16
6,528,853


1701
A2BP1
16
6,691,358
1702
A2BP1
16
6,974,269


1703
HYDIN
16
69,783,066
1704
A2BP1
16
6,980,934


1705
HYDIN
16
69,818,152
1706
A2BP1
16
7,234,640


1707
A2BP1
16
7,551,379
1708
WWOX
16
76,643,771


1709
WWOX
16
76,655,506
1710
WWOX
16
76,669,786


1711
WWOX
16
76,672,696
1712
WWOX
16
76,674,781


1713
WWOX
16
77,016,308
1714
MPHOSPH6
16
80,705,905


1715
MPHOSPH6
16
80,722,907
1716
MPHOSPH6
16
80,723,078


1717
MPHOSPH6
16
80,728,084
1718
CDH13
16
81,390,450


1719
CMH3
16
81,426,803
1720
CDH13
16
81,436,845


1721
CDH13
16
81,470,072
1722
CDH13
16
81,474,183


1723
CDH13
16
81,477,191
1724
CDH13
16
81,481,182


1725
CDH13
16
81,487,112
1726
CDH13
16
81,906,325


1727
CDH13
16
81,917,154
1728
CDH13
16
81,919,816


1729
CDH13
16
82,194,302
1730
CDH13
16
82,357,323


1731
USP10
16
83,331,937
1732
USP10
16
83,371,654


1733
CRISPLD2
16
83,443,278
1734
CRISPLD2
16
83,443,531


1735
CRISPLD2
16
83,475,493
1736
CRISPLD2
16
83,476,363


1737
CRISPLD2
16
83,484,480
1738
CRISPLD2
16
83,484,845


1739
CRISPLD2
16
83,497,517
1740
DNAH9
17
11,591,782


1741
DNAH9
17
11,672,736
1742
DNAH9
17
11,862,669


1743
RAB11FIP4
17
27,005,299
1744
CA10
17
47,163,241


1745
CA10
17
47,434,848
1746
CA10
17
47,528,183


1747
CA10
17
47,534,336
1748
CA10
17
47,547,164


1749
CA10
17
47,599,744
1750
CA10
17
48,292,853


1751
MSI2
17
52,817,244
1752
MS12
17
52,993,137


1753
MSI2
17
53,122,443
1754
SDK2
17
68,829,410


1755
HRNBP3
17
74,857,410
1756
HRNBP3
17
75,313,214


1757
OSBPL1A
18
20,042,294
1758
OSBPL1A
18
20,093,929


1759
OSBPL1A
18
20,243,361
1760
CHST9
18
22,886,548


1761
CHST9
18
22,965,754
1762
CH5T9
18
23,000,286


1763
DLGAP1
18
3,829,680
1764
DLGAP1
18
3,840,002


1765
ZFP161
18
5,398,814
1766
NEDD4L
18
54,010,852


1767
NEDD4L
18
54,013,845
1768
NEDD4L
18
54,014,157


1769
NEDD4L
18
54,016,611
1770
NEDD4L
18
54,028,916


1771
NEDD4L
18
54,100,941
1772
NEDD4L
18
54,258,677


1773
NEDD4L
18
54,259,246
1774
CCBE1
18
55,241,702


1775
CCBE1
18
55,487,763
1776
CDH7
18
61,273,210


1777
CDH7
18
61,289,294
1778
CDH7
18
61,305,341


1779
CDH7
18
61,305,944
1780
CDH7
18
61,586,240


1781
CDH7
18
61,590,121
1782
CDH7
18
61,594,009


1783
CDH7
18
61,594,926
1784
CDH7
18
61,594,980


1785
CDH7
18
61,595,280
1786
CDH7
18
61,595,696


1787
CDH7
18
61,627,079
1788
CDH7
18
61,668,497


1789
CDH7
18
61,688,917
1790
CDH7
18
61,715,545


1791
DOK6
18
65,238,984
1792
DOK6
18
65,437,835


1793
DOK6
18
65,516,648
1794
DOK6
18
65,516,906


1795
MBP
18
72,823,708
1796
MBP
18
73,018,369


1797
PTPRM
18
7,522,635
1798
PTPRM
18
7,585,927


1799
PTPRM
18
8,277,805
1800
PTPRM
18
8,288,088


1801
PTPRM
18
8,288,633
1802
KIAA0802
18
8,689,988


1803
KIAA0802
18
8,788,185
1804
KIAA0802
18
8,820,180


1805
LDLR
19
11,067,530
1806
LDLR
19
11,102,877


1807
LDLR
19
11,103,658
1808
ZNF667
19
61,678,984


1809
MACROD2
20
14,275,899
1810
MACROD2
20
15,551,153


1811
MACROD2
20
15,890,876
1812
MACROD2
20
15,992,978


1813
KIF16B
20
16,221,665
1814
KIF16B
20
16,221,933


1815
KIF16B
20
16,270,199
1816
KIF16B
20
16,275,325


1817
KIFI6B
20
16,275,825
1818
KIF16B
20
16,284,694


1819
KIF16B
20
16,294,439
1820
KIF16B
20
16,294,523


1821
KIF16B
20
16,307,567
1822
KIF16B
20
16,314,615


1823
KIF16B
20
16,371,330
1824
KIF16B
20
16,420,825


1825
KIF16B
20
16,459,991
1826
KIF16B
20
16,476,914


1827
KIF16B
20
16,591,934
1828
MAPRE1
20
30,888,730


1829
MAPRE1
20
30,891,296
1830
PTPRT
20
40,079,104


1831
PTPRT
20
40,112,645
1832
PTPRT
20
40,141,648


1833
PTPRT
20
40,143,404
1834
PTPRT
20
40,153,367


1835
PTPRT
20
40,176,580
1836
PTPRT
20
40,534,688


1837
PTPRT
20
40,759,651
1838
PTPRT
20
40,766,955


1839
PTPRT
20
40,832,585
1840
PRNT
20
4,676,075


1841
KCNB1
20
47,439,714
1842
KCNB1
20
47,440,607


1843
KCNB1
20
47,543,084
1844
KCNB1
20
47,550,362


1845
KCNB1
20
47,554,184
1846
CDH4
20
59,349,681


1847
CDH4
20
59,359,672
1848
CDH4
20
59,708,754


1849
CDH4
20
59,852,651
1850
CDH4
20
59,854,564


1851
CDH4
20
59,936,745
1852
FERMT1
20
6,011,187


1853
FERMT1
20
6,037,797
1854
FERMT1
20
6,048,088


1855
FERMT1
20
6,162,234
1856
PLCB1
20
8,082,140


1857
PLCB1
20
8,092,135
1858
PLCB1
20
8,159,200


1859
PLCB4
20
9,133,981
1860
PLCB4
20
9,173,164


1861
C210RF37
21
17,711,037
1862
NCAM2
21
21,717,043


1863
NCAM2
21
21,722,038
1864
NCAM2
21
21,849,510


1865
ERG
21
38,941,206
1866
ERG
21
38,947,119


1867
ERG
21
38,989,365
1868
PCP4
21
40,145,066


1869
PCP4
21
40,147,412
1870
SLC37A1
21
42,866,712


1871
SLC37A1
21
42,871,651
1872
SLC37A1
21
42,877,191


1873
ARVCF
22
18,342,203
1874
SGSM1
22
23,675,537


1875
HPS4
22
25,192,153
1876
ARFGAP3
22
41,576,090


1877
ARFGAP3
22
41,590,371
1878
ARFGAP3
22
41,591,167


1879
PACSIN2
22
41,629,654
1880
PACSIN2
22
41,645,337


1881
PACSIN2
22
41,679,576
1882
PACSIN2
22
41,685,200


1883
PACSIN2
22
41,686,443
1884
PACSIN2
22
41,686,643


1885
PACSIN2
22
41,723,929
1886
PACSIN2
22
41,726,053


1887
PACSIN2
22
41,727,507
1888
PACSIN2
22
41,729,950


1889
PACSIN2
22
41,730,708
1890
TTLL1
22
41,796,161


1891
TTLL1
22
41,822,583
1892
TTLL1
22
41,822,906


1893
EFCAB6
22
42,278,436
1894
EFCAB6
22
42,320,777

## Claims

1. A method of determining likelihood of having a schizophrenia (SZ) endophenotype in a human subject, the method comprising:
obtaining a sample comprising genomic DNA of the subject;
determining the presence of an A allele at rs2779400 in the sample;
wherein the presence of an A allele at rs2779400 indicates that the subject is more likely to have a schizophrenia endophenotype of a lower PANSS Total composite score, a lower PANSS General Psychopathology composite score, a lower G3 score, and a lower G13 score, as compared to a subject who does not have an A allele at rs2779400.

2. The method of claim 1, wherein determining the identity of the nucleotide comprises contacting the sample with a probe specific for a selected allele of the polymorphism, and detecting the formation of complexes between the probe and the selected allele of the polymorphism, wherein the formation of complexes between the probe and the test marker indicates the presence of the selected allele in the sample.

3. The method of the claim 1, wherein determining the identity of an allele comprises determining the identity of the nucleotide at position 31 of SEQ ID NO:66.

4. The method of claim 1, wherein the subject is a patient having or suspected of having SZ.

5. The method of claim 1, wherein the subject has one or more risk factors associated with SZ.

6. The method of claim 5, wherein the risk factors associated with SZ include one or more of: a relative afflicted with a schizophrenia spectrum disorder (SSD); and a genetically based phenotypic trait associated with risk for a SSD.

7. The method of claim 1, further comprising selecting or excluding a subject for enrollment in a clinical trial based on the identity of the allele.

8. The method of claim 1 further comprising stratifying a subject population for analysis of a clinical trial based on the identity of the allele in the subjects.

9. The method of claim 1, further comprising confirming a severity of a SZ endophenotype using psychometric instruments.

10. The method of claim 1, further comprising recording the identity of the allele in a tangible medium.

11. The method of claim 10, wherein the tangible medium comprises a computer-readable disk, a solid state memory device, or an optical storage device.