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BLOO D LEA D AN D BLOO D PRESSUR E

T . Moreau , G . Orssaud , B . Juguet , and C . Susque t

Rev . Epidemiol . Sant e Publique , vol . 30 , ?age s 39 5 397 , 1982 .

Translate d fo r EP Aby : S C I T RA N 148 2 Eas tValle y Roa d Sant aBarbara , Californi a9310 8 (805 ) 969-241 3 f lP. 3

Lette r t o th

e Edi to

r Bloo d lea dan d bloo d pressure . Preliminar y

result s o f a cross-sectiona l stud y o f 43 1 mal e subjects. * Gentlemen t A narticl e dealin g wit hth e factor s o f variatio no f bloo d lead i

nthe genera l populatio n(Awad e t al . Cll ) wa s publishe d i

na recen t issue o f the review ; amon g othe r things , i

t di d no t establis ha relationshi pbetweenbloo d lea d andbloo dpressure . U e presen t her e th e preliminar y

result s o f a stud y i n whic hthi s relationshi p i s shown . Th e stud

y populatio ni s mad e u po f 43 1 mal e subjects , age d 2 4 t o S S year s (averag e 41.4) , untreate d for hypertension , belongin g t o th e Pari s polic e department . Fo r eac hsubject , examine d durin g a routin e medica l visit , bloo d pressur e wa s measure d wit ha mercur y apparatus ; a blood sampl e wa s collected ; th e leve l o f lea

dwa s measure do

ntota l bloo d b

y atomi c absorptio nspectrometr y <Jare11-As h83 8 apparatus) ; an

d th e dail y

Consumption s o f win e an dtobacc o wer e obtaine d b

y questionnaire . Dat a wer e collecte dfro m May 198 8 t o Februar y

1981 . Statistica l test s wer e carrie dout usin g th

e logarithm s o f th e bloo d leadvalues , whic happeare d t o be normall y

distributed .
Uor k carrie d ou t unde r INSER M CR L contrac t no . 79-5-438-8 . By i T . Moreau .P. 4

Th e averag e bloo d leadvalue s a s a functio no f systoli c bloo d pressur e ar e show ni nTabl e lt the

y diffe r vry significantl y

( p< 18-* ) wit hanincreas e o f abou t 2S X betwee nth

e lowes t bloo d pressur e clas s (les s tha n12 8 m

m Hg ) and th a highes t bloo d pressur e clas s (ove r 16 8 m m Hg) , the correlatio ncoefficien t valu e i s 8.2 3 ( p< 18-*> . Also , th e bloo dlead , a s i nAwa d e t al . til , appear s vry significantl y

correlate dwit hag e ( r « 8.28 , p< 18-*) , consumptio no f win e an d tobacc o ( r • 8.31 , p< 18-* ; r • 8.21 i p < 18-* , respectively) . However , th e blood lead-systoli c pressur e relationshi ppersist s afte r taking int o accoun t simultaneousl y th e .thre e variable s (partia l correlatio ncoefficien t 8.16 , p< 18-3) . i t wa s als o corroborate db

y th e existenc e o f a significan t correlatio n betwee nbloo dlead andcardia c rate , itsel f vry muchlinke d t o systoli c pressure ; th e correlatio ndisappear s afte r takin g th e linkag e int o account . Takin g int o accoun t corpulenc e (define da s th

e rati o Ueight/Height*) , no t correlate d wit hbloo dlead ( r » 8.85) , doe s no t alte r thes e results . Finall y

i t ha s be,*

nverifie d tha t th e bloo dlead-systoli c pressur e relationshi pexist s for eac ho f th e mor e homogeneou s group s o f subject s examine d durin g a give nmonth . A s fa r a s diastoli c pressur e i s concerned , it i s als o linkedi na significan t manne r t o bloo dleadlevels , bu t mor e loosel y <r
• 8.18 , p < 8.85) ; th e weaknes s o f thi s correlatio ni s probabl y

explaine d b

y th e poore r qualit y

o f th e diastoli cP. 5

prttsur t measurement , a s suggeste db y it s wta k relationshi p t o ag * an

dcorpulenc e <

r - 8.18 , r - 8.21 , respectively) , compare d t o tha t observe d-fo r systoli c pressur e ( r - 8.28 , r
• 8.34 , respectively) . Th e existenc e o f a positiv e connectio nbetwee nbloo d lea d an dbloo d pressur e i s controversia l i nth e recen t literature s i

t wa s show

nb y Beever s e

t al . C2 , 3 3 an

dKher a t t a l . C4 ] who , wit ha grou pidentica l t o our s wit hrespec t t o se xan d profession , compare d averag e bloo dlea dleve l o f subject s wit helevate d bloo d pressur e wit htha t o f othe r subjects . Th e statistica l analysi s chose nhere , a s wel l a s i nAwa d e t a

l . , i s different , sinc e i t consist s o* calculatin g th

e correlatio nbetwee nbloo dleve l an dbloo d pressur e i

nth e genera l population . Lookin g a

t thes e result s together , i t appear s necessar y t o conduc t othe r stqdie s tha t wil l permit , i nparticular , approachin g th

e physiologica l mechanism s of th e blood lead-bloo d pressur e relationship . * T . Morea u<1) , 6 . Orssaud(2) , B . Jugue t <3) , 6 . Busque t (4) .
(1 ) INSERM , U . 16 ? (J . Lellouch) , 16 , av . Paul-Vai1 1 ant Couterier , 9788 7 Vi11ejui f Cedex . (2 ) Laborator y

for Researc hi

nCardiovascula r Disease s o f th e DASS , 27 , ru e Lacordair e F 7381 3 Pari s <Pr . J.-R . Claude) . <3 > Healt hLaborator y o f th e Cit y o f Paris , 1(2) , rue de s Hos p i tal i ers-Sa i nt-Gerva i s , F 7381 3 Pari s (.Pr . B . Festy ) . (4 ) Departmen t o f Nuclea r Medicine , CHRG , F 3878 8 L a Tronche .P. 6

TABL E 1 . Mean s o f bloo d lea d value s (ug/£ ) accordin g t o blood-pressur e (m m Hg )
1 ^ 

## Z~ I-

• tl * 12 0 - U » 13 0 • 13 9 I' M • I« t ISO - I M l« 0 • 1* 1 « » I M • 4 7 lf l a 0 7 l. l a S T a na S T X M a 01 n 10 1 11 9 7 1

, < i0- <

l Systoli c pressure . 'Bloo d lea d ± standar d error . ^Numbe r o f subjects . 4 Significanc eP. 7



# ist e
BIBLIOGRAPH Y
1 . Awa d L * | Hu* l G. , Laza r P. , Bouden e C i Factor s o f inte r individua l variatio n i n bloo d lead . Rev . Epidemiol , e t Sant e Publ. , 1981 , 2Z. 113-124 .

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