Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 421148



### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY

AND POLLUT I ON PREVENTION



### MEMORANDUM

DATE: 07/17/2014

SUBJECT: Pyraclostrobin. Acute and Chronic Aggregate Dietary ( Food and Drinking Water) Exposure and Risk Assessments to Support New Uses on Dill Seed and

Herbs Subgroup 19A.

PC Code: 099100

Decision No.: 484923 DP Barcode: 421148 Registration No.: 7969-185; 7969-199;

7969-258

Petition No.: 3E82 16 Regulatory Action: Sect ion 3 Registration

Risk Assessment Type: Dietary Case No.: None

TXR No. : None CAS No.: 175013-18-0

MRJD Nos.: 47014801, 47014802,

47014803 40 CFR: 180.582

FROM:

THROUGH:

TO: Stephen Funk

, Senior Chemist 

# A J I

Risk Assessment Branch III 

# i**~** Health Effects Division (7509 P)

, . / 

# .4---

Thurston Morton,

# Senio~~st**/D~-7~/'6** Pete r Savoia

, Chemist

# c_/**~ ~~**  Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

and 

# tJl!;t:!

Christine Olinger, Br anch Chief

Risk Assessment Branch 

### II I

- - Health Effects Division (7509P) /

Andrew Ertman

Barbara Madden

Pagel of39Pyraclostrobin Dietary Exposure and Risk Assessment



### Fungicid e Branch Registration Division (7505P)

Barry 0 ' Keefe

, Ri sk Assessor

Risk Assessment Branch III

Health Effects Division (7509P)

Page 2 of39 DP Number: 42114 8Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 3 of 39 

### Executive Summary

Acute and chronic aggregate dietary exposure and risk ass essments were conducted using the Dietary Exposure Evaluation Model (DEEM

- FCIDTM), Version 3.16, which is based on

NHANES 2

- day food consumption data from 2003

- 2008. The analyses were conducted in support of a human

- health risk assessment for the proposed Section 3 uses of pyraclostrobin on dill seed and crop subgroup 19A herbs. This memorandum was reviewed by two peer reviewers of the DESAC per the DESAC SOP.

The last dietary risk assessment for pyraclostrobin was performed in 20 13 (DP Barcode

# 410739

, S . Funk ) to support a new use on sugarcane, persimmon, globe artichoke, and Belgium

endive . That assessment has been updated by new estimated per cent crop treated data from

BEAD ( 02/26/2014 ) , by confirmation of the existing drinking water concentration l evel

estimates from EFED

, and by the addition of new commodities ( dill seed, herbs)

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

A slightly refined acute dietary exposure assessment was perfo r med for pyraclostrobin. T he analysis used tolerance

- level residues or highest field trial residues

, 100% crop treated

, and empirical or default processing factors. Experimentally derived processing factors were used for fruit juices

, tomato

, sugar cane, and wheat commodities

. For all other processed commodities, DEEM default processing factors were assumed. Estimated drinking water concentrations (EDWCs) were also used

. The estimated acute drinking water concentration for pyraclostrobin ( 0.0356 ppm ) was calculated based on a tu rf scenario for surface water.

The results of the acute dietary analysis for food and drinking water indicate that acute dietary

risks do not exceed the Agency ’s level of concern ( < 100% of the aPAD) for the U.S. population and all subgroups. Combined dietary exposure from food and drinking water at the 95 th


### percentile of exposure for the U.S. population is equivalent to 1.5 % of the acute Population Adjusted Dose (aPAD). The population subgroup with the highest estimated acute dietary

exposure to pyrac lostrobin is females 13

- 49 years , with a n estimated exposure at the 95 th


### percentile of 8 7 % of the aPAD.

Chronic Dietary (Food and Drinking Water ) Exposure Results and Characterization

A refined chronic dietary analysis was conducted for this assessment i n order to compensate for exposure resulting from residential uses in the aggregate assessment. T he chronic dieta ry analysis included tolerance

- level or average field trial residues

, average percent crop treated

estimate s (20 14 ) when available

, and empiri cal processing factors. Screening level estimates of agricultural uses of pyraclostrobin w ere provided previously by the Biological & Economic Analysis Division (BEAD). E xperimentally derived processing fa ctor s were used for fruit juices,

tomato , sugar c ane, and wheat commodities

. For all other processed commodities, DEEM default processing factors were assumed

. The estimated drinking water concentration for pyraclostrobin ( 0.0023 ppm ) was calculated based on a turf scenario for surface water ( D403871,Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 4 of 39 

### D405066, F. Khan, 02/13/2013 ) and confirmed in consideration of the new uses on dill seed and herbs (D417303, D. Seifu, 06/2014)

.

The results of the refined chronic dietary (food and drinking water) analysis are below the Agency’s level of concer n for all population subgroups

. The dietary exposure for food and

drin k ing water for the general U.S. population is 8.1 % of the chronic Population Adjusted Dose (c PAD ) and 2 7 % of the cPAD for children 1

- 2 yrs , the population subgroup with the highest

estimated chronic dietary exposure to pyraclostrobin.

Cancer Dietary Exposure Results and Characterization

The Cancer Assessment Review Committee ( CARC ) concluded that the pyraclostrobin is “not likely to be carcinogenic to humans

. ” T herefore, a cancer dietary exp osure assessment was not
conducted.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the do se which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the point of d eparture ( PO D , NOAEL, LOAEL ) divided by the required uncertainty or s afety f actor s

.

For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk

exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA

- PEST/2000/July/Day

- 12/6061.pdf ; or se e SOP 99.6 (8/20/99).

II. Residue Information

Pyraclostrobin belongs to the strobilurin class of fungicides. Strobilurins are synthetic analogs of a natural antifungal substance which inhibits spore germination, mycelial growth, and sporulation of the f

ungus on the leaf surface. Pyraclostrobin tolerances have been established in 40 CFR §180.582. Tolerances for plant commodities are listed in 40 CFR §180.582 (a)(1) for residues of the fungicide pyraclostrobin , including its metabolites and degradates. Compli an ce with the tolerance levels is to be determined by measuring only the sum of pyraclostrobin (carbamic acid, [2

- [[[1

- (4

- chlorophenyl)

- 1 H

- pyrazol

- 3

- yl]oxy]methyl]phenyl]methoxy

- , methyl ester) and its desmethoxy metabolite

, methyl 2

- [[[1

- (4

- chloro phenyl)

- 1 H

- pyrazol

- 3

- yl]oxy]methyl]phenyl carbamate, calculated as the stoichiometric equivalent of pyraclostrobin.

The HED Metabolism Assessment Review Committee (MARC memo of 10/9/01, DP# 278044, L. Cheng) determined that for purposes of tolerance and dietary risk assessments, the residues of concern in plant and rotational crop commodities include pyraclostrobin and the desmethoxy

metabolite. The residues of concern in livestock commodities include pyraclostrobin and itsPyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

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Page 5 of 39 

### metabolites convertible to 1

- ( 4

- chlorophenyl)

- 1 H

- pyrazol

- 3

- ol and 1

- (4

- chloro

- 2

- hydroxyphenyl)

- 1 H

- pyrazol

- 3

- ol.

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009,

and 2010. Over t his 3

- year period, PDP analyzed 1479 samples of catfish for pyr aclostrobin residues. None of the samples contained detectable residues (lod about 0.0 15 ppm) . As a result,

residues in fish were not included in the assessment.

The potential for secondary transfer of pyraclostrobin residues of concern in meat, milk, poultry, and eggs exists because there are several livestock feedstuffs that are associated with the existing uses. The proposed uses do not add to the potential for transfer, as the new commodities do not include livestock feed items of regulatory intere st. A summary of the proposed and

recommended tolerances for the new uses are listed in Table 1.

Table 1. Tolerance Summary for Pyraclostrobin for New Uses Commodity Proposed Tolerance (ppm) Recommended Tolerance (ppm)
Herb subgroup 19A 85 40
Dill, seed 100 40



### Pyraclostrobin and the desmethoxy metabolite were determined separately in the field trial samples, and the combined residue was calculated as pyraclostrobin.

Residue Data used for Acute and Chronic Assessments:

For the acute dietary analy sis, tolerance or highest average field trial residues (HAFT) and one hundred percent crop treated was assumed for all commodities

.

For the refined chronic dietary analysis, average field trial residues were calculated for certain

crops ( coffee, sorghum grain, stone fruits crop group 12, apple, broccoli, celery, collard, grape, lettuce, citrus, pepper, mustard green

, and tomato )

, which are the major dietary con tributors

based on preliminary run s

. Average field trial values were also used for the commodit ies persimmon, Belgium endive, sugarcane, and globe artichoke. Field trial data were translated

from the representative commodities to the non

- representative commodities according to HED SOP 2000.1:”Guidance for Translation of Field Trial Data from Repres entative Commodities in the Crop Group Regulation to other Commodities in Each Crop Group/Subgroup.”

Residue values used for acute and chronic assessments for some of the existing uses are listed in

Table 2. For those not listed, including crop group 19 A and dill seed, tolerance level residues

were used.

Table 2. Residue Data used for Acute and Chronic Dietary Risk Assessments.

Commodity Acute (Tolerance, Highest Field Trial Residues, HR )

(ppm) Chronic (Average Residues,

AR ) (ppm)
Amaranth, leaf

y HR (23.38) AR (11.77)
Arugula HR (23.38) AR (11.77)Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

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Page 6 of 39 Table 2. Residue Data used for Acute and Chronic Dietary Risk Assessments.

Commodity Acute (Tolerance, Highest Field Trial Residues, HR )

(ppm) Chronic (Average Residues,

AR ) (ppm) Chrysanthemum HR (23.38) AR (11.77)
Cress, garden HR (23.38) AR (11.77)
Cress, upland HR (23.38) AR (11.77)

Dandelion, leaves / endive HR (23.38) AR (11.77)

Fennel HR (23.38) AR (5.02)
Parsley, le aves HR (23.38) AR (11.77)

Radicchio HR (23.38) AR (0.59)

Rhubarb HR (23.38) AR (5.02)
Spinach HR (23.38) AR (11.77)

Swiss chard HR (23.38) AR (5.02)
Apple Tol (1.5) AR (0.31)
Beans, dry HR (0.21) Tol (0.5)

Broccoli Tol (5.0) AR (1.10)
Celery HR (1 0.7) AR (5.02)
Chickpea, seed HR (0.34) HR (0.34)

Collards Tol (16.0) AR (5.74)
Grape Tol (2.0) AR (0.768)
Guar, seed HR (0.34) Tol (0.5)
Herbs (19A) Tol (40) Tol (40)
Lettuce, head HR (14.4) AR (0.59)
Lettuce, leaf HR (20.1) AR (7.68)
Mustard gree ns Tol (16.0) AR (5.74)
Orange Tol (2.0) AR (0.3)
Pea, dry HR (0.1) Tol (0.5)

Tomato Tol (1.4) AR (0.158)
Apricot Tol (2.5) AR (0.602)
Cherry (sweet & sour) Tol (2.5) AR (0.846)

Nectarine Tol (2.5) AR (0.602)

Peach Tol (2.5) AR (0.602)

Plum Tol ( 2.5) AR (0.198)

Coffee Tol (0.3) AR (0.064)
Sorghum, grain Tol (0.6) AR (0.09)
Artichoke, globe Tol (3.0) AR (0.84)
Endive, Belgium Tol (4.0) AR (0.82)

Persimmon Tol (3.0) AR (0.60)

Sugarcane, cane Tol (0.2) AR (0.076)



### Experimentally derived proce ssing factors for s everal commodities were applied. For all other processed commodities, DEEM (ver. 7.81) default processing factors were assumed. See Table

3.Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

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Page 7 of 39 Table 3. Processing Factors for Pyraclostrobin Dietary Risk

Assessment. Commodity PF Ap ple, juice 0.2

Apple, juice

- babyfood 0.2

Beet, sugar 0.4

Beet, sugar

- babyfood 0.4

Beet, sugar, molasses 0.4

Beet, sugar, molasses

- babyfood 0.4

Corn, field, syrup 1.5

Flaxseed, oil 1.2

Grape, juice 0.01

Grape, juice

- babyfood 0.01

Grapefrui t, juice 0.02

Grape

- raisins 1.0

Lemon, juice 0.02

Lemon, juice

- babyfood 0.02

Lime, juice 0.02

Lime, juice

- babyfood 0.02

Orange, juice 0.02

Orange, juice

- babyfood 0.02

Peach, dried 7.0

Plums

– prunes dried 1.3

Plums

- prunes dried

- babyfood 1.3

Potato, dry (granules/ flakes) 6.5 1

Potato, dry (granules/ flakes)

- babyfood 6.5 1

Potato, flour 6.5 1

Potato, flour

- babyfood 6.5 1

Sugarcane, sugar 0.15

Sugrcane, molasses 0.15

Tangerine, juice 0.02

Tomato, paste 2.1

Tomato, puree 0.55

Wheat (T riticale), flour 0.7

Wheat (Triticale), flour

- babyfood 0.7

Wheat , germ 0.85

1 Factor reduced to 1 based on use of tolerance for potato.



### BEAD has provided updated percent crop treated information for pyraclostrobin ( J. Alsadek

, 02/26/2014 ). For th e chronic analyses only , the weighted average %CT was incorporated , which

i s listed as Adjustment Factor 2 in the DEEM

- FCID R 0 8 file

. One hundred percent crop treated

was assumed for commodities with no % CT information

.Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

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Page 8 of 39 

### III Percent Crop Treated Infor mation

The following average percent crop treated estimates were used in the chronic dietary risk assessments for the crops that are currently registered for pyraclostrobin: almonds 40%; apples 15%; apricots 25%; barley 10%; green beans <2. 5%; blueberrie s 45%; broccoli 5%; cabbage

10 % ; c an e berries 50%; cantaloupes 15%; carrots 35%; cauliflower <2.5%; celery <2.5%; cherries 50%; corn 10%; cotton <2.5%; cotton (seed treatment) 10%; cucumber 10 %; dry beans/peas 10%; garlic 1 0 %; grapefruit 30 %; grapes 30%; ha zelnuts (filberts) 20 %; lemons <2.5%; lettu ce 5%; nectarines 10%; onions 25 % ; oranges 5%; peaches 20%; peanuts 25%; pears 15%; green peas 5 %; pecans <2.5%; peppers 10%; pi stachios 30 % ; plums/prunes 5%; potatoes

20 %; pumpkins 20%; rice <1%; soybeans 5% ; soy beans (seed treatment) 5%; spinach 5%; squash 15%; strawberries 65%; sugar beets 45%; sugarcane 10 %; sweet corn 5%; tangelos 15%; tangerines 10%; tomatoes 2 5%; walnuts <1%; watermelons 30% ; wheat 5% ; wheat (seed treatment) <1%

. Note that the sugarcane est imate is from a time limited Section 18 (exp 12/2014) and not the Section 3 registration (2013)

. Therefore, 100% crop treated was used for

sugarcane.

IV Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the

Environmental Fate and Effects Division ( EFED; D403871, D405066, F. Khan, 02/13/2013

, Addendum 04/ 04 / 2013 ) and incorporated directly into this dietary assessment. Water residues were incorporated in the DEEM

- FCID into the food categories “water, dir ect, all sources” and

“w ater, indirect, all sources.” The new uses on herbs and dill seed were considered by EFED, and no change from the 2013 values was con sidered necessary (EFED: D417303, E. Seifu, 06/2014).

For surface water, the estimated drinking w ater concentrations ( EDWCs ) were generated using EFED’s standard suite of models. Pesticide Root Zone Model (PRZM v3.12.2, May 12, 2005) and Exposure Analysis Modeling System (EXAMS v2.98.04.06, Apr. 25, 2005) are simulation models coupled with the input shell PRZM/EXAMS (PE v5.0, Nov. 15, 2006) to generate EDWCs of pyraclostrobin residues that may occur in surface water for drinking water. For ground water, Screening Concentration in Ground Water (SCI

- GROW v2.3, Jul. 29, 2003) is a regression model used as a screening tool to estimate pesticide concentrations found in ground water used as drinking water.

The use of pyraclostrobin in fruiting vegetables resulted in the highest surface water concentrations of at 16.6 μg/L for 1

- 10 year peak value from grou nd application and 1

- 10 annual year average of 1.1 μg/L from aerial application. The acute and chronic EDWCs resulting from the proposed application uses are lower than the EDWCs for surface water in the previously recommended drinking water assessments fo r pyraclostrobin for turf uses ( USEPA 2007

D389729 + )

. Since the EDWCs for surface water for proposed uses are lower than the previously recommended EDWCs for this chemical, the EDWCs for surface water will not supersede the

E DWCs previously recommended for turf use.

The turf use is the same evaluation provided previously by EFED and originally used in a 2007 assessment (D389729, 9/6/2007). All proposed new uses were considered.Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

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Page 9 of 39 

### Table 4 provides a summary of the estimated con centrations of pyraclostrobin in surface water. In the acute analysis, the 1

- in

- 10 year peak surface water value of 35.6 ppb was used and in the chronic analysis the surface water value of 2.3 ppb was used. Estimates of p yraclostrobin

concentration in dri nking water were less for groundwater sources

. The models and their descriptions are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/

.

Table 4. EDWCs of Pyraclo strobin

Crop Scenario PRZM/EXAMS Estimated Concentrations in Surface Water (  g/L)

Acute 1 (μg/L) Chronic (μg/L)

Surface Water

NJ Nursery (no irrigation)

Turf 35.6 2.3

Groundwater 2

N/A 0.02 0.02

1 These are the highest EDWCs for previously evaluated use scenarios and the estimated acute and annual average surface water

concen trations were 35.6 and 2.3 μg/L respectively. Previously estimated groundwater concentrations for acute was 0.02 μg/L
2007, D389729

. 2 EDWCs based on PRZM

- GW model



### . V

. DEEM

- FCIDTM Program and Consumption Information

Pyraclostrobin acute and chronic die tary exposure assessments were conducted using the DEEM

FCID, Version 3.16, which incorporates 2003

- 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000

individuals over two non

- consecutive su rvey days. Foods “as consumed” (e.g., apple pie) are

linked to EPA

- defined food commodities (e.g., apples, peeled fruit

- cooked; fresh or N/S; baked;

or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files develope d jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. However, for acute exposure assessment, consumption data are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. populatio n, all infants (<1 year old), children

1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., ora nge or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each popu lation subgroup.

For an acute exposure assessment, individual one

- day food consumption data are used on an

individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obta in a total daily pesticide exposure for aPyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

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Page 10 of 39 

### deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage o f the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita

expo sure and risk are reported for analyses performed at all levels of refinement. However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

V I

. Toxicological Information

The toxicity endpoints pertinent for human risk assessment are summarized in Table 5

.

Table 5. Summary of Toxicological Doses and Endpoints for Pyraclostrobin for Use in Dietary Human

Health Risk Assessments.

Exposure/

Scenar io Point of

Departure Uncertainty/

FQPA Safety

Factors RfD, PAD, Level

of Concern for

Risk Assessment Study and Toxicological Effects

Acute Dietary (General Population, including

Infants and Children) NOAEL =

300 mg/kg/day UF A = 10x

UF H = 10x FQPA SF= 1x Acute RfD = 3.0

mg/kg/day

aPAD = 3.0 mg/kg/day Rat Acute Oral Neurotoxicity

LOAEL = 1000 mg/kg/day based on decreased body weight gain in males.

Acute Dietary (Females 13

- 49 years of age) NOAEL= 5.0

mg/kg/day UF A = 10x

UF H = 10x FQP A SF= 1x Acute RfD = 0.05

mg/kg/day

aPAD = 0.05 mg/kg/day Rabbit Prenatal Developmental

Toxicity LOAEL = 10.0 mg/kg/day based on developmental toxicity findings of increased resorptions.

Chronic Dietary (All Populations) NOAEL= 3.4

mg/kg/day UF A = 10x

UF H = 10x FQPA SF= 1x Chronic RfD =

0.034 mg/kg/day

cPAD = 0.034 mg/kg/day Rat Oral Carcinogenicity

LOAEL = 9.2 mg/kg/day based on decreased body weight/body weight gain, kidney tubular casts and atrophy in both sexes; increased incide nce of

liver necrosis and erosion/ulceration of the glandular

- stomach and fore

stomach in males.

Cancer (oral) Classification: “Not likely to be Carcinogenic to Humans” based on the absence of significant

tumor increases in two adequate rodent carcino genicity studies.

. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty

factor. UF A = extrapolation from animal to human (int er species). UF H = potential variation in sensitivity among

members of t he human population (int ra species). UF L = use of a LOAEL to extrapolate a NOAEL. FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose.



### V I I. Results/DiscussionPyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

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Page 11 of 39 

### As stated above, for acute and chr onic assessments, HED is concerned when dietary risk exceeds

100% of the PAD. The DEEM

- FCIDTM analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 6 and 7 are for the general U.S. Po pulation, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth

13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years.

Results of Acute Dietary (Food and Drinking Water) Exposure Analysis

The results of the acute dietary ana lysis for food and drinking water indicate that acute dietary

risks do not exceed the Agency ’s level of concern at the 95 th 

### percentile ( < 100% of the aPAD) for the U.S. population and all subgroups. At the 95 th 

### percentile, the U.S. population has an

exposu re from food and drinking water that results in a risk estimate for the general U.S. population of 1.5 % of the aPAD. The most highly exposed subpopulation is “females 13

- 49 years” at 8 7 % of the aPAD.

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The results of the aggregate chronic dietary analysis for food and drinking water are below the Agency’s level of concern (<100% cPAD) for the general U.S. population ( 8. 1 % cPAD) and all population subgroups. The most highly exposed p opulation su bgroup is children 1

- 2 yrs at 2 7 %

of the cPAD. The results of the acute and chronic dietary exposure analys e s are reported in

Table 6 below.

Table 6. Summary of Dietary Exposure and Risk for Pyraclostrobin Food & Drinking Water.

Population Subgroup Acute Dietary (95 th Percentile) Chronic Dietary Cancer

Dietary Exposure (mg/kg/day) %

aPAD Dietary

Exposure (mg/kg/day) %

cPAD Dietary

Exposure (mg/kg/day) Risk

General U.S. Population 0.04687 1.5 0.002 742 8.1

A separate quantitative cancer

ri sk assessment is not required. All Infants (< 1 year old) 0.06 1725 2. 1 0.004082 12.

Children 1

- 2 years old 0. 083114 2. 8 0.009231 27.

Children 3

- 5 years old 0.07 4744 2.5 0.006258 18.

Children 6

- 12 years old 0.04 4276 1.5 0.003566 11.

Youth 13

- 19 y ears old 0.031 310 1.0 0.001869 5.5

Adults 20

- 49 years old 0.04 1809 1.4 0.002269 6.7

Adults 50

- 99 years old 0.04 1843 1.4 0.002282 6.7

Females 13

- 49 years old 0.0 43510 87 0.002049 6.0

*The subpopulations with the highest risk estimates are bolded.



### C ancer Dietary Exposure Results and CharacterizationPyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

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Page 12 of 39 

### As noted above, the HED CARC revisited the cancer classification for pyraclostrobin. HED has reclassified pyraclostrobin as “not likely to be carcinogenic to humans

. " Therefore, a cancer dietary expos ure analysis was not conducted.

IX

. Characterization of Inputs/Outputs

In the course of conducting a refined dietary exposure analysis, decisions are made regarding the following: the residue data used in the analysis (e.g., field trials, monitoring dat a, etc.), refinements incorporated in the analysis (such as percent crop treated and processing factors), and a variety of other issues which may be chemical

- or crop

- specific.

The acute and chronic dietary risk assessments are considered only minimally refined. For this assessment, tolerance

- level residues and field trial residue data were incorporated in the dietary analyses. The use of field trial data in the assessment is unlikely to underestimate actual

exposure because field trial data reflects co nservative pesticide residues at the minimum pre

harvest interval and the maximum application rate permitted on the proposed or existing labels.

Further refine ments could have been carried out with the use of field trial residue data in those

instances wh ere tolerance level residue values were utilized.

One hundred percent crop treated was assumed for the acute analysis

. The chronic assessment utilized average %CT estimates when available. Further refinements could have been carried out

if additional %C T estimates were used.

A limited number of experimentally derived processing factors were used to refine the acute and chronic analyse s

. Default DEEM processing factors were incorporated for all other processed

commodities. The inclusion of additio nal empirical processing factors could also refine the dietary assessment.

Estimated drinking water concentrations for surface water were also incorporated

. The

contribution of residues in drinking water to the dietary risk is minimal

.

IX. Conclusion s

Dietary risks for pyraclostrobin are below HED’s level of concern for dietary exposure and risk.

Females 13

- 49 years old are the most highly exposed popul ation subgroup for acute exposure,

with risks estimates at 87 % of the aPAD at the 95 th 

### percentile of exposure

. Children 1

- 2 years old are the most highly exposed popul ation subgroup for chronic exposure, with risks estimates

at 2 7 % of the cPAD. Risks were lower for all other population subgroups, including the general

U

. S

. population. The acute and c hronic dietary exposure assessments sup port the new uses and

amendments proposed for pyraclostrobin

.

X. List of Attachments

Attachment 1. Pyraclostrobin Acute Dietary Analysis Input File

- Food & Water

. Attachment 2

. Pyraclostrobin Acute Dietary Ana lysis Results

- Food & Water

. Attachment 3. Pyraclostrobin Acute Dietary Analysis Results

– FoodPyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 13 of 39 

### Attachment 4 . Pyraclostrobin Chronic Dietary Analysis Input File

- Food & Water

. Attachment 5

. Pyraclostrobin Chronic Dietary Analysis Results

- Food & Wat er

. Attachment 6. Pyraclostrobin Chronic Dietary Analysis Results

– Food.

Attachment 7 . Pyraclostrobin Screening Level Usage Analysis (SLUA)

.

Attachment 1 . Pyraclostrobin Acute Dietary Analysis Input File

– Food & Water

Filename: E: \ RAB3_2014 \ Boscalid Pyraclo \ DEEM \ PyracloAcuteR08_07_17_14.R08 Chemical: Pyraclostrobin RfD(Chronic): .034 mg/kg bw/day NOEL(Chronic): 3.4 mg/kg bw/day RfD(Acute): 3 mg/kg bw/day NOEL(Acute): 300 mg/kg bw/day
Date created/last modified: 07

- 17

- 2014/07:24:30 Program ver . 3.16,

03

- 08

- d Comment: Food and drinking water

--------------------------------------------------------------------------

--------- EPA Crop Def Res Adj.Factors

Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------

------- 0101050000 1AB Beet, garden, roots 0.400000 1.000 1.000 0101050001 1AB Beet, garden, roots

- babyfood 0.400000 1.000 1.000 0101052000 1A Beet, sugar 0.200000 0.400 1.000 0101052001 1A Beet, sugar

- babyfood 0.200000 0.400 1.000 0101053000 1A Beet, sugar, molasses 0.200000 0.400 1.000

0101053 001 1A Beet, sugar, molasses

- babyfood 0.200000 0.400 1.000

0101067000 1AB Burdock 0.400000 1.000 1.000

0101078000 1AB Carrot 0.400000 1.000 1.000

0101078001 1AB Carrot

- babyfood 0.400000 1.000 1.000 0101079000 1AB Carrot, juice 0.400000 1.000 1.000

0101084000 1AB Celeriac 0.400000 1.000 1.000 0101100000 1AB Chicory, roots 0.4000 00 1.000 1.000 0101168000 1AB Ginseng, dried 0.400000 1.000 1.000

0101190000 1AB Horseradish 0.400000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.400000 1.000 1.000

01012 51000 1AB Parsnip 0.400000 1.000 1.000 0101251001 1AB Parsnip

- babyfood 0.400000 1.000 1.000
0101314000 1AB Radish, roots 0.400000 1.000 1.000
0101316000 1AB Radish, Orient al, roots 0.400000 1.000 1.000 0101327000 1AB Rutabaga 0.400000 1.000 1.000 0101331000 1AB Salsify, roots 0.400000 1.000 1.000 0101388000 1AB Turnip, roots 0.40 0000 1.000 1.000
0103015000 1CD Arrowroot, flour 0.040000 1.000 1.000
0103015001 1CD Arrowroot, flour

- babyfood 0.040000 1.000 1.000
0103017000 1CD Artichoke, Jerusalem 0.040000 1.000 1.000

010 3082000 1CD Cassava 0.040000 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.040000 1.000 1.000
0103139000 1CD Dasheen, corm 0.040000 1.000 1.000 0103166000 1CD Ginger 0.040000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.040000 1.000 1.000 0103167000 1CD Ginger, dried 0.040000 1.000 1.000 0103296000 1C Potato, chips 0. 040000 1.000 1.000Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 14 of 39 0103297000 1C Potato, dry (granules/ flakes) 0.040000 1.000 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.040000 1.000 1.000
0103298000 1C Potato, flour 0.040000 1.000 1.000

0 103298001 1C Potato, flour

- babyfood 0.040000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.040000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.040000 1.000 1.000
0103300000 1C Potato, tu ber, w/o peel 0.040000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.040000 1.000 1.000 0103366000 1CD Sweet potato 0.040000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 0.040000 1.000 1.000
0103371000 1CD Tanier, corm 0.040000 1.000 1.000

0103387000 1CD Turmeric 0.040000 1.000 1.000
0103406000 1CD Yam, true 0.040000 1.000 1.000

0103407000 1CD Yam bean 0.040000 1.000 1.000 0200051000 2 Beet, garden, tops 16.000000 1.000 1.000 0200101000 2 Chicory, tops 16.000000 1.000 1.000
0200140000 2 Dasheen, leaves 16.000000 1.000 1.000
0301165000 3A Garlic, bulb 0.900000 1.000 1.000
0301165001 3A Garlic, bulb

- babyfood 0.900000 1.000 1.000
0301237000 3A Onion, bulb 0.900000 1.000 1.000
0301237001 3A Onion, bulb

- babyfood 0.900000 1.000 1.000
0301238000 3A Onion, bulb, dried 0.900000 9.000 1.000
0301238001 3A Onion, bulb, dried

- babyfood 0.900000 9.000 1.000
0301338000 3A Shallot, bulb 0.900000 1.000 1.000
0302103000 3B Chive, fresh leaves 25.000000 1.000 1.000

0302198000 3B Leek 0.900000 1.000 1.000
0302239000 3B Onion, green 0.900000 1.000 1.000
0302338500 3B Shallot, fresh leaves 0.900000 1.000 1.000 0401005000 4A Amaranth, leafy 23.380000 1.000 1.000 0401018000 4A Arugula 23.380000 1.000 1.000 0401104000 4A Chrysanthemum, garland 23.380000 1.000 1.000 0401133000 4A Cress, garden 23.380000 1.000 1.000 0401134000 4A Cress, upland 23.380000 1.000 1.0 00
0401138000 4A Dandelion, leaves 23.380000 1.000 1.000

0401150000 4A Endive 23.380000 1.000 1.000
0401204000 4A Lettuce, head 14.400000 1.000 1.000

0401205000 4A Lett uce, leaf 20.100000 1.000 1.000 0401248000 4A Parsley, leaves 23.380000 1.000 1.000

0401313000 4A Radicchio 23.380000 1.000 1.000 0401355000 4A Spinach 23.380000 1.000 1.000 0401355001 4A Spinach

- babyfood 23.380000 1.000 1.000

0402076000 4B Cardoon 23.380000 1.000 1.000 0402085000 4B Celery 10.700000 1.000 1 .000 0402085001 4B Celery

- babyfood 10.700000 1.000 1.000 0402086000 4B Celery, juice 10.700000 1.000 1.000

0402087000 4B Celtuce 10.700000 1.000 1.000

0402152000 4B Fe nnel, Florence 23.380000 1.000 1.000

0402322000 4B Rhubarb 23.380000 1.000 1.000

0402367000 4B Swiss chard 23.380000 1.000 1.000

0501061000 5A Broccoli 5.000000 1.000 1.000

0501061001 5A Broccoli

- babyfood 5.000000 1.000 1.000
0501062000 5A Broccoli, Chinese 5.000000 1.000 1.000 0501064000 5A Brussels sprouts 5.000000 1.000 1.000 0501069000 5A Cabbage 5.000000 1.000 1.000Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 15 of 39 0501071000 5A Cabbage, Chinese, napa 5.000000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 5.000000 1.000 1.000

0501083000 5A Cauliflower 5.000000 1.000 1.000

0501196000 5A Kohlrabi 5.000000 1.000 1.000

0502063000 5B Broccoli raab 16.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok cho y 16.000000 1.000 1.000

0502117000 5B Collards 16.000000 1.000 1.000

0502194000 5B Kale 16.000000 1.000 1.000 0502229000 5B Mustard greens 16.000000 1.00 0 1.000 0502318000 5B Rape greens 16.000000 1.000 1.000 0502389000 5B Turnip, greens 16.000000 1.000 1.000 0600347000 6 Soybean, seed 0.040000 1.000 1.000

0600349000 6 Soybean, soy milk 0.040000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 0.040000 1.000 1.000 0600350000 6 Soybean, oil 0.040000 0.800 1.000 0600350001 6 Soybean, oil

- babyfood 0.040000 0.800 1.000 0601043000 6A Bean, snap, succulent 0.500000 1.000 1.000 0601043001 6A Bean, snap, succulent

- babyfood 0.500000 1.000 1.000 0601257000 6A Pea, edible podded, succulent 0.500000 1. 000 1.000 0601349500 6AB Soybean, vegetable 0.500000 1.000 1.000
0602031000 6B Bean, broad, succulent 0.500000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.500000 1.000 1.000

0602037000 6 B Bean, lima, succulent 0.500000 1.000 1.000
0602255000 6B Pea, succulent 0.200000 1.000 1.000
0602255001 6B Pea, succulent

- babyfood 0.200000 1.000 1.000 0602259000 6B Pea, pigeon, succulen t 0.200000 1.000 1.000
0603030000 6C Bean, black, seed 0.210000 1.000 1.000
0603032000 6C Bean, broad, seed 0.210000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.210000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.210000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.210000 1.000 1.000
0603038000 6C Bean, lima, seed 0.210000 1.000 1.000

0603039000 6C Bean, mung, seed 0.210000 1.000 1.000 0603040000 6C Bean, navy, seed 0.210000 1.000 1.000 0603041000 6C Bean, pink, seed 0.210000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.210000 1.000 1.000 0603098000 6C Chickpea, seed 0.340000 1.000 1.000 0603098001 6C Chickpea, seed

- babyfood 0.340000 1.000 1.000 0603099000 6C Chickpea, flour 0.340000 1.000 1.000
0603182000 6C Guar, seed 0.340000 1.000 1.000
0603182001 6C Guar, seed

- babyfood 0.340000 1.000 1.000
0603203000 6C Lentil, seed 0.340000 1.000 1.000

06032560 00 6C Pea, dry 0.100000 1.000 1.000 0603256001 6C Pea, dry

- babyfood 0.100000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.100000 1.000 1.000 0603348000 6C Soybean, flour 0.040000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 0.040000 1.000 1.000

0801374000 8A Tomatillo 1.400000 1.000 1.000

0801375000 8A Tomato 1.40000 0 1.000 1.000

0801375001 8A Tomato

- babyfood 1.400000 1.000 1.000 0801376000 8A Tomato, paste 1.400000 2.100 1.000 0801376001 8A Tomato, paste

- babyfood 1.400000 2.100 1.000

080137 7000 8A Tomato, puree 1.400000 0.550 1.000 0801377001 8A Tomato, puree

- babyfood 1.400000 0.550 1.000Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 16 of 39 0801378000 8A Tomato, dried 1.400000 14.300 1.000
0801378001 8A Tomato, dried

- b abyfood 1.400000 14.300 1.000 0801379000 8A Tomato, juice 1.400000 1.500 1.000
0801380000 8A Tomato, Tree 1.400000 1.000 1.000 0802148000 8BC Eggplant 1.400 000 1.000 1.000

0802234000 8BC Okra 1.400000 1.000 1.000 0802270000 8B Pepper, bell 1.400000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 1.400000 1.000 1.000

0802 271000 8B Pepper, bell, dried 1.400000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 1.400000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.400000 1.000 1.000 0802272001 8BC Pepper, nonbe ll

- babyfood 1.400000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.400000 1.000 1.000 0901075000 9A Cantaloupe 0.500000 1.000 1.000 0901187000 9A Honeydew melon 0.5 00000 1.000 1.000

0901399000 9A Watermelon 0.500000 1.000 1.000 0901400000 9A Watermelon, juice 0.500000 1.000 1.000 0902021000 9B Balsam pear 0.500000 1.000 1.000

09 02088000 9B Chayote, fruit 0.500000 1.000 1.000 0902102000 9B Chinese waxgourd 0.500000 1.000 1.000

0902135000 9B Cucumber 0.500000 1.000 1.000 0902308000 9B Pumpkin 0.500000 1.000 1.000 0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 0902356000 9B Squash, summer 0.500000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0 .500000 1.000 1.000 0902357000 9B Squash, winter 0.500000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.500000 1.000 1.000

1001106000 10A Citron 2.000000 1.000 1.000 1001107000 10A Citrus hybrids 2.000000 1.000 1.000
1001108000 10A Citrus, oil 9.000000 1.000 1.000 1001240000 10A Orange 2.000000 1.000 1.000 1001241000 10A Orange, j uice 2.000000 0.020 1.000 1001241001 10A Orange, juice

- babyfood 2.000000 0.020 1.000 1001242000 10A Orange, peel 2.000000 1.000 1.000 1001369000 10A Tangerine 2.000000 1.000 1.000 1001370000 10A Tangerine, juice 2.000000 0.020 1.000 1002197000 10B Kumquat 2.000000 1.000 1.000

1002199000 10B Lemon 2.000000 1.000 1.000 1002200000 10B Lemon, juice 2.000000 0.020 1.000 1002200001 10B Lemon, juice

- babyfood 2.000000 0.020 1.000 1002201000 10B Lemon, peel 2.000000 1.000 1.000

1002206000 10B Lime 2.000000 1.000 1.000 1002207000 10B Lime, juice 2.000000 0.020 1.000 1002207001 10B Lime, juice

- babyfood 2.000000 0.020 1.000 1003180000 10C Grapefruit 2.000000 1.000 1.000 1003181000 10C Grapefruit, juice 2.000000 0.020 1.000

1003307000 10C Pummelo 2.000000 1.000 1.000 1100007000 11 Apple, fruit with peel 1.500000 1.000 1.00 0 1100008000 11 Apple, peeled fruit 1.500000 1.000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 1.500000 1.000 1.000 1100009000 11 Apple, dried 1.500000 8.000 1.000 1100009001 11 Apple , dried

- babyfood 1.500000 8.000 1.000 1100010000 11 Apple, juice 1.500000 0.200 1.000 1100010001 11 Apple, juice

- babyfood 1.500000 0.200 1.000Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 17 of 39 1100011000 11 Apple, sauce 1.500000 1.000 1.000 1100011001 11 Apple, sauce

- babyfood 1.500000 1.000 1.000 1100129000 11 Crabapple 1.500000 1.000 1.000 1100173500 11 Goji berry 1.500000 1.000 1. 000 1100210000 11 Loquat 1.500000 1.000 1.000

1100266000 11 Pear 1.500000 1.000 1.000

1100266001 11 Pear

- babyfood 1.500000 1.000 1.000

1100267000 11 Pea r, dried 1.500000 6.250 1.000 1100268000 11 Pear, juice 1.500000 1.000 1.000 1100268001 11 Pear, juice

- babyfood 1.500000 1.000 1.000
1100310000 11 Quince 1.500000 1.000 1.000 1201090000 12A Cherry 2.500000 1.000 1.000 1201090001 12A Cherry

- babyfood 2.500000 1.000 1.000 1201091000 12A Cherry, juice 2.500000 1.500 1.000 1201091001 12A Cherry, juice

- babyfood 2.500000 1.500 1.000 1202012000 12B Apricot 2.500000 1.000 1.000 1202012001 12B Apricot

- babyfood 2.500000 1.000 1.000

1202013000 12B A pricot, dried 2.500000 6.000 1.000 1202014000 12B Apricot, juice 2.500000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 2.500000 1.000 1.000

1202230000 12B Nectarine 2.500000 1.000 1.000

1202260000 12B Peach 2.500000 1.000 1.000

1202260001 12B Peach

- babyfood 2.500000 1.000 1.000
1202261000 12B Peach, dried 2.500000 7.000 1.000
1202261001 12B Peach, dried

- babyfood 2.500000 7.000 1.000 1202262000 12B Peach, juice 2.500000 1.000 1.000 1202262001 12B Peach, juice

- babyfood 2.500000 1.000 1.000

1203285000 12C Plum 2.500000 1.000 1.000

1203285001 12C Plum

- babyfood 2.500000 1.000 1.000 1203286000 12C Plum, prune, fresh 2.500000 1.000 1.000 1203286001 12C Plum, prune, fresh

- babyf ood 2.500000 1.000 1.000 1203287000 12C Plum, prune, dried 2.500000 1.300 1.000 1203287001 12C Plum, prune, dried

- babyfood 2.500000 1.300 1.000 1203288000 12C Plum, prune, juice 2.500000 1.4 00 1.000 1203288001 12C Plum, prune, juice

- babyfood 2.500000 1.400 1.000 1301055000 13A Blackberry 4.000000 1.000 1.000 1301056000 13A Blackberry, juice 4.000000 1.000 1.000

1301056001 13 A Blackberry, juice

- babyfood 4.000000 1.000 1.000 1301058000 13A Boysenberry 4.000000 1.000 1.000 1301208000 13A Loganberry 4.000000 1.000 1.000 1301320000 13A Raspberry 4.000000 1.000 1.000 1301320001 13A Raspberry

- babyfood 4.000000 1.000 1.000 1301321000 13A Raspberry, juice 4.000000 1.000 1.000 1301321001 13A Raspberry, juice

- babyfood 4.000000 1 .000 1.000 1302057000 13B Blueberry 4.000000 1.000 1.000 1302057001 13B Blueberry

- babyfood 4.000000 1.000 1.000

1302136000 13B Currant 4.000000 1.000 1.000

1302137000 13B Currant, dried 4.000000 1.000 1.000 1302149000 13B Elderberry 4.000000 1.000 1.000 1302174000 13B Gooseberry 4.000000 1.000 1.000 1302191000 13B Huckleberry 4.000000 1.000 1.000 1303227000 13C Mulberry 4.000000 1.000 1.000 1304175000 13D Grape 2.000000 1.000 1.000 1304176000 13D Grape, juice 2.000000 0.010 1.000Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 18 of 39 1304176001 13D Grape, juice

- babyfood 2.000000 0.010 1.000 1304179000 13D Grape, wine and sherry 2.000000 1.000 1.000 1307359000 13G Strawberry 4.000000 1.000 1.000

130735900 1 13G Strawberry

- babyfood 1.200000 1.000 1.000 1307360000 13G Strawberry, juice 1.200000 1.000 1.000 1307360001 13G Strawberry, juice

- babyfood 1.200000 1.000 1.000

1400003000 14 Almond 0.040000 1.000 1.000

1400003001 14 Almond

- babyfood 0.040000 1.000 1.000
1400004000 14 Almond, oil 0.040000 1.000 1.000
1400004001 14 Almond, oil

- babyfood 0.040000 1.000 1.000

1400059000 14 Brazil nut 0.040000 1.000 1.000

1400068000 14 Butternut 0.040000 1.000 1.000

1400081000 14 Cashew 0.040000 1.000 1.000

1400092 000 14 Chestnut 0.040000 1.000 1.000

1400155000 14 Hazelnut 0.040000 1.000 1.000
1400156000 14 Hazelnut, oil 0.040000 1.000 1.000 1400185000 14 Hickory nut 0.040000 1.000 1.000

1400213000 14 Macadamia nut 0.040000 1.000 1.000

1400269000 14 Pecan 0.040000 1.000 1.000

1400278000 14 Pine nut 0.0400 00 1.000 1.000

1400282000 14 Pistachio 0.700000 1.000 1.000

1400391000 14 Walnut 0.040000 1.000 1.000 1500025000 15 Barley, pearled barley 1.400000 1.000 1.000

15000 25001 15 Barley, pearled barley

- babyfood 1.400000 1.000 1.000 1500026000 15 Barley, flour 1.400000 1.000 1.000 1500026001 15 Barley, flour

- babyfood 1.400000 1.000 1.000 1500027000 15 Barley, bran 1.400000 1.000 1.000
1500120000 15 Corn, field, flour 0.100000 1.000 1.000
1500120001 15 Corn, field, flour

- babyfood 0.100000 1.000 1.000
1500121000 15 Corn, field, meal 0.10 0000 1.000 1.000
1500121001 15 Corn, field, meal

- babyfood 0.100000 1.000 1.000
1500122000 15 Corn, field, bran 0.100000 1.000 1.000
1500123000 15 Corn, field, starch 0.100000 1.000 1.000

150 0123001 15 Corn, field, starch

- babyfood 0.100000 1.000 1.000 1500124000 15 Corn, field, syrup 0.100000 1.500 1.000 1500124001 15 Corn, field, syrup

- babyfood 0.100000 1.500 1.000
1500125000 15 Corn, field, oil 0.200000 1.000 1.000
1500125001 15 Corn, field, oil

- babyfood 0.200000 1.000 1.000 1500126000 15 Corn, pop 0.100000 1.000 1.000
1500127000 15 Corn, sweet 0. 040000 1.000 1.000
1500127001 15 Corn, sweet

- babyfood 0.040000 1.000 1.000
1500231000 15 Oat, bran 1.200000 1.000 1.000
1500232000 15 Oat, flour 1.200000 1.000 1.000

1 500232001 15 Oat, flour

- babyfood 1.200000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 1.200000 1.000 1.000 1500233001 15 Oat, groats/rolled oats

- babyfood 1.200000 1.000 1.000 1500328000 15 Rye, grain 0.040000 1.000 1.000 1500344000 15 Sorghum, grain 0.600000 1.000 1.000 1500345000 15 Sorghum, syrup 0.600000 1.000 1.000
1500381000 15 Triticale, flour 0.020000 0.700 1.000
1500381001 15 Triticale, flour

- babyfood 0.020000 1.000 1.000 1500401000 15 Wheat, grain 0.020000 1.000 1.000 1500401001 15 Wheat, grain

- babyfood 0.020000 1.000 1.000
1500402000 15 Wheat, flour 0.020000 0.700 1.000Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 19 of 39 1500402001 15 Wheat, flour

- babyfood 0.020000 0.700 1.000 1500403000 15 Wheat, germ 0.020000 0.850 1.000
1500404000 15 Wheat, b ran 0.020000 1.000 1.000
1901028000 19A Basil, fresh leaves 40.000000 1.000 1.000
1901028001 19A Basil, fresh leaves

- babyfood 40.000000 1.000 1.000
1901029000 19A Basil, dried leaves 40.000000 1.000 1.000
1901029001 19A Basil, dried leaves

- babyfood 40.000000 1.000 1.000
1901102500 19A Chive, dried leaves 40.000000 1.000 1.000
1901118000 19A Cilantro, leaves 40.000000 1.000 1.000
1901118001 19A Cilantro, leaves

- babyfood 40.000000 1.000 1.000

1901144000 19A Dillweed 40.000000 1.000 1.000
1901184000 19A Herbs, other 40.000000 1.000 1.000
1901184001 19A Herbs, other

- babyfood 40.000000 1.000 1.000 1901202000 19A Lemongrass 40.000000 1.000 1.000 1901220000 19A Marjoram 40.000000 1.000 1.000 1901220001 19A Marjoram

- babyfood 40.000000 1.000 1.000 1901249000 19A Parsley, dried leaves 40.000000 1.000 1.000 1901249001 19A Parsley, dried leaves

- babyfood 40.000000 1.000 1.000 1901334000 19A Savory 40.000000 1.000 1.0 00
1902143000 19B Dill, seed 40.000000 1.000 1.000
2001163000 20A Flax seed, oil 0.450000 1.200 1.000 2001319000 20A Rapeseed, oil 0.450000 1.000 1.000 2001319001 20A Rape seed, oil

- babyfood 0.450000 1.000 1.000
2001336000 20A Sesame, seed 0.450000 1.000 1.000
2001336001 20A Sesame, seed

- babyfood 0.450000 1.000 1.000
2001337000 20A Sesame, oil 0.450000 1.000 1.000
2001337001 20A Sesame, oil

- babyfood 0.450000 1.000 1.000
2002330000 20B Safflower, oil 0.450000 1.000 1.000
2002330001 20B Safflower, oil

- babyfood 0.450000 1.000 1 .000
2002364000 20B Sunflower, seed 0.450000 1.000 1.000
2002365000 20B Sunflower, oil 0.450000 1.000 1.000
2002365001 20B Sunflower, oil

- babyfood 0.450000 1.000 1.000

2003114001 20C Co conut, oil

- babyfood 0.450000 1.000 1.000
2003128000 20C Cottonseed, oil 0.450000 1.000 1.000
2003128001 20C Cottonseed, oil

- babyfood 0.450000 1.000 1.000
3100044000 31 Beef, meat 0.100000 1.000 1.000
3100044001 31 Beef, meat

- babyfood 0.100000 1.000 1.000
3100045000 31 Beef, meat, dried 0.100000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 3100046001 31 Beef, meat byproducts

- babyfood 0.200000 1.000 1.000
3100047000 31 Beef, fat 0.100000 1.000 1.000
3100047001 31 Beef, fat

- babyfood 0.100000 1.000 1.000

3100048000 31 Beef, kidney 0.200000 1.000 1.000
3100049000 31 Beef, liver 1.500000 1.000 1.000
3100049001 31 Beef, liver

- babyfood 1.500000 1.000 1.000
3200169000 32 Goat, meat 0.100000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000
3200171000 32 Goat, fat 0.100000 1.000 1.000 3200172000 32 Goat, kidney 0.200000 1.00 0 1.000
3200173000 32 Goat, liver 1.500000 1.000 1.000
3300189000 33 Horse, meat 0.100000 1.000 1.000
3400290000 34 Pork, meat 0.100000 1.000 1.000

3400290001 34 Pork, meat

- babyfood 0.100000 1.000 1.000
3400291000 34 Pork, skin 0.100000 1.000 1.000Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 20 of 39 3400292000 34 Pork, meat byproducts 0.200000 1.000 1.000 3400292001 34 Pork, meat byproducts

- b abyfood 0.200000 1.000 1.000
3400293000 34 Pork, fat 0.100000 1.000 1.000
3400293001 34 Pork, fat

- babyfood 0.100000 1.000 1.000 3400294000 34 Pork, kidney 0.200000 1. 000 1.000
3400295000 34 Pork, liver 1.500000 1.000 1.000 3500339000 35 Sheep, meat 0.100000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.100000 1.000 1.000

3500340000 3 5 Sheep, meat byproducts 0.200000 1.000 1.000 3500341000 35 Sheep, fat 0.100000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.100000 1.000 1.000 3500342000 35 Sheep, kidney 0.200000 1.000 1.000 3500343000 35 Sheep, liver 1.500000 1.000 1.000
3600222000 36 Milk, fat 0.100000 1.000 1.000
3600222001 36 Milk, fat

- baby food/infant formu 0.100000 1.000 1.000
3600223000 36 Milk, nonfat solids 0.100000 1.000 1.000
3600223001 36 Milk, nonfat solids

- baby food/in 0.100000 1.000 1.000
3600224000 36 Milk, water 0.100000 1.000 1.000

3600224001 36 Milk, water

- babyfood/infant form 0.100000 1.000 1.000
3600225001 36 Milk, sugar (lactose)

- baby food/ 0.100000 1.000 1.000
3800221000 38 Meat, game 0.100000 1.000 1.000
3900312000 39 Rabbit, meat 0.100000 1.000 1.000
4000093000 40 Chicken, meat 0.100000 1.000 1.000
4000093001 40 Chicken, meat

- babyfood 0.100000 1.000 1.000
4000094000 40 Chicken, liver 0.100000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.100000 1.000 1.000 4000095001 40 Chicken, meat byproducts

- babyfoo 0.100000 1.000 1.000
4000096000 40 Chicken, fat 0.100000 1.000 1.000

40000960 01 40 Chicken, fat

- babyfood 0.100000 1.000 1.000
4000097000 40 Chicken, skin 0.100000 1.000 1.000
4000097001 40 Chicken, skin

- babyfood 0.100000 1.000 1.000 5000382000 50 Turkey, meat 0.100000 1.000 1.000 5000382001 50 Turkey, meat

- babyfood 0.100000 1.000 1.000 5000383000 50 Turkey, liver 0.100000 1.000 1.000 5000383001 50 Turkey, liver

- babyfood 0.10000 0 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.100000 1.000 1.000 5000384001 50 Turkey, meat byproducts

- babyfood 0.100000 1.000 1.000 5000385000 50 Turkey, fat 0.100000 1.000 1.000

500038 5001 50 Turkey, fat

- babyfood 0.100000 1.000 1.000 5000386000 50 Turkey, skin 0.100000 1.000 1.000 5000386001 50 Turkey, skin

- babyfood 0.100000 1.000 1.000 6000301000 60 Poultry, other, meat 0.100000 1.000 1.000 6000302000 60 Poultry, other, liver 0.100000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.100000 1.000 1.000 6000304000 60 Poultry, other, fat 0.100 000 1.000 1.000 6000305000 60 Poultry, other, skin 0.100000 1.000 1.000 7000145000 70 Egg, whole 0.100000 1.000 1.000 7000145001 70 Egg, whole

- babyfood 0.100000 1.000 1.000

7000 146000 70 Egg, white 0.100000 1.000 1.000 7000146001 70 Egg, white (solids)

- babyfood 0.100000 1.000 1.000 7000147000 70 Egg, yolk 0.100000 1.000 1.000 7000147001 70 Egg, yolk

- bab yfood 0.100000 1.000 1.000
8601000000 86A Water, direct, all sources 0.035600 1.000 1.000
8602000000 86B Water, indirect, all sources 0.035600 1.000 1.000Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 21 of 39 9500016000 O Artichoke, globe 3.0 00000 1.000 1.000

9500020000 O Avocado 0.600000 1.000 1.000

9500023000 O Banana 0.040000 1.000 1.000

9500023001 O Banana

- babyfood 0.040000 1.000 1.000

95 00024000 O Banana, dried 0.040000 3.900 1.000
9500024001 O Banana, dried

- babyfood 0.040000 3.900 1.000 9500054000 O Belgium endive 4.000000 1.000 1.000

9500074000 O Canistel 0.600000 1.000 1.000
9500115000 O Coffee, roasted bean 0.300000 1.000 1.000
9500116000 O Coffee, instant 0.300000 1.000 1.000 9500177000 O Grape, leaves 2 .000000 1.000 1.000 9500178000 O Grape, raisin 7.000000 1.000 1.000 9500188000 O Hop 23.000000 1.000 1.000 9500215000 O Mango 0.600000 1.000 1.000 9500215001 O Mango

- babyfood 0.600000 1.000 1.000 9500216000 O Mango, dried 0.600000 1.000 1.000 9500217000 O Mango, juice 0.600000 1.000 1.000 9500217001 O Mango, ju ice

- babyfood 0.600000 1.000 1.000 9500245000 O Papaya 0.600000 1.000 1.000 9500245001 O Papaya

- babyfood 0.600000 1.000 1.000 9500246000 O Papaya, dried 0.600000 1.800 1.000 9500247000 O Papaya, juice 0.600000 1.500 1.000

9500263000 O Peanut 0.050000 1.000 1.000
9500264000 O Peanut, butter 0.050000 1.890 1.000
9500265000 O Peanut, oil 0.100000 1.000 1.000 9500275000 O Peppermint 8.000000 1.000 1.000 9500276000 O Peppermint, oil 8.000000 1.000 1.000

9500277000 O Persimm on 3.000000 1.000 1.000

9500283000 O Plantain 0.040000 1.000 1.000
9500284000 O Plantain, dried 0.040000 3.900 1.000 9500333000 O Sapote, Mamey 0.600000 1.000 1.000 9500352000 O Spearmint 8.000000 1.000 1.000 9500353000 O Spearmint, oil 8.000000 1.000 1.000 9500362000 O Sugarcane, sugar 0.200000 0.150 1.00 0 9500362001 O Sugarcane, sugar

- babyfood 0.200000 0.150 1.000 9500363000 O Sugarcane, molasses 0.200000 0.150 1.000 9500363001 O Sugarcane, molasses

- babyfood 0.200000 0.150 1.000Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 22 of 39 

### Attachment 2

. Pyraclostrobin Acute Dietary Analysis Results

– Food & Water

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for PYRACLOSTROBIN NHANES 2003

- 2008

2

- Day Residue file: PyracloAcuteR08_07_ 17_14.R08 Adjustment factor #2 NOT

used. Analysis Date: 07

- 17

- 2014/07:29:18 Residue file dated: 07

- 17

- 2014/07:24:30 NOEL (Acute) = 300.000000 mg/kg body

- wt/day
RAC/FF intake summed over 24 hours
Run Comment: "Food and drinking water"

============ ==============================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population:

0.044687 1.49 6713 0.077361 2.58 3877 0.126956 4.23 2363

All Infants:

0.061725 2.06 4860 0.094159 3 .14 3186 0.255536 8.52 1174

Children 1

- 2:

0.083114 2.77 3609 0.126311 4.21 2375 0.200286 6.68 1497

Children 3

- 5:

0.074744 2.49 4013 0.125316 4.18 2393 0.201911 6.73 1485

Children 6

- 12:

0.044276 1.48 6775 0.074224 2.47 4041 0.110905 3.70 2705

Youth 13

- 19:

0.031310 1.04 9581 0.059010 1.97 5083 0.112940 3.76 2656

Adults 20

- 49:

0.041809 1.39 7175 0.072527 2.42 4136 0. 115935 3.86 2587

Adults 50

- 99:

0.041843 1.39 7169 0.069260 2.31 4331 0.118365 3.95 2534Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 23 of 39 US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for PYRACLO STROBIN NHANES 2003

- 2008

2

- Day Residue file: PyracloAcuteR08_07_17_14.R08 Adjustment factor #2 NOT

used. Analysis Date: 07

- 17

- 2014/07:45:32 Residue file dated: 07

- 17

- 2014/07:24:30 NOEL (Acute) = 5.000000 mg/kg body

- wt/day
RAC/FF in take summed over 24 hours Run Comment: "Food and drinking water"

==========================================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th

Percentile

-- -- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD

MOE

Female 13

- 49:

0.043510 87.02 114 0.074076 148.15 67 0.120771 241.54 41Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 24 of 39 

### Attachment 3 . Pyraclostrobin Acute Dietary Analysis Results

– Food

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for PYRACLOSTROBIN NHANES 2003

- 2008

2

- Day Residue file: PyracloAcuteR08_07_17_14_NOwater.R08 Adjustment factor #2 NOT used. Analysis Date: 07

- 17

- 2014/07:34:59 Residue file dated: 07

- 17

- 2014/07:32:46 NOEL (Acute) = 300.000000 mg/kg body

- wt/day
RAC/FF intake summed over 24 hours
Run Comment: "Food only"

==========================================================================

Summary calcu lations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population:

0.043752 1.46 6856 0.076602 2.55 3916 0.127241 4.24 2357

All Infants:

0.060383 2.01 4968 0.091551 3.05 3276 0.252060 8.40 1190

Children 1

- 2:

0.081491 2.72 3681 0.124695 4.16 2405 0.199860 6.66 1501

Children 3

- 5:

0.073717 2.46 4069 0.123514 4.12 2428 0.199006 6.63 1507

Children 6

- 12:

0.042964 1.43 6982 0.073286 2.44 4093 0.108336 3.61 2769

Youth 13

- 19:

0.030758 1.03 9753 0.058031 1.93 5169 0.110983 3.70 2703

Adults 20

- 49:

0.040433 1.35 7419 0.071372 2.38 4203 0.114645 3.82 2616

Adults 50

- 99:

0.040646 1.35 7380 0.068296 2.28 4392 0.115631 3.85 2594

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for PYRACLOSTROBIN NHANES 2003

- 2008

2

- Day Residue file: PyracloAcuteR08_07_17_14_NOwater.R08

Ad justment factor #2 NOT used. Analysis Date: 07

- 17

- 2014/09:50:23 Residue file dated: 07

- 17

- 2014/07:32:46 NOEL (Acute) = 5.000000 mg/kg body

- wt/day
RAC/FF intake summed over 24 hours

Run Comment: "Food only "

============================================= ============================= Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th

Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- ----- --- ---------- ------- -------- ---------- ------- -------- Female 13

- 49:

0.042504 85.01 117 0.072803 145.61 68 0.119816 239.63 41Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 25 of 39 

### Attachment 4 . Pyraclostrobin Chronic Dietary Analysis Input

File

– Food & Water

Filename: E: \ RAB3_2014 \ BoscalidPyraclo \ DEEM \ PyracloChronic07_17_14.R08 Chemical: Pyraclostrobin RfD(Chronic): .034 mg/kg bw/day NOEL(Chronic): 3.4 mg/kg bw/day RfD(Acute): 3 mg/kg bw/day NOEL(Acute): 300 mg/kg bw/day
Date created/last modified: 07

- 17

- 2014/08:07:45 Program ver. 3.16,

03

- 08

- d Comment: Food and drinking water

--------------------------------------------------------------------------

--------- EPA Crop Def Res Adj.Factors

Comment Code Grp Commo dity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------

------- 0101050000 1AB Beet, garden, roots 0.400000 1.000 1.000 0101050001 1AB Beet, garden, roots

- babyfo od 0.400000 1.000 1.000 0101052000 1A Beet, sugar 0.200000 0.400 0.450 0101052001 1A Beet, sugar

- babyfood 0.200000 0.400 0.450 0101053000 1A Beet, sugar, molasses 0.200000 0.400 0.450 0101053001 1A Beet, sugar, molasses

- babyfood 0.200000 0.400 0.450

0101067000 1AB Burdock 0.400000 1.000 1.000

0101078000 1AB Carrot 0.400000 1.000 0.350

0101078001 1AB Carrot

- babyfood 0.400000 1.000 0.350 0101079000 1AB Carrot, juice 0.400000 1.000 0.350

0101084000 1AB Celeriac 0.400000 1.000 1.000 0101100000 1AB Chicory, roots 0.400000 1.000 1.000 0101168000 1AB Ginseng, dried 0.400000 1.000 1.000

0101190000 1AB Horseradish 0.400000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.400000 1.0 00 1.000 0101251000 1AB Parsnip 0.400000 1.000 1.000 0101251001 1AB Parsnip

- babyfood 0.400000 1.000 1.000
0101314000 1AB Radish, roots 0.400000 1.000 1.000

0101316000 1A B Radish, Oriental, roots 0.400000 1.000 1.000 0101327000 1AB Rutabaga 0.400000 1.000 1.000 0101331000 1AB Salsify, roots 0.400000 1.000 1.000 0101388000 1AB Turnip, roots 0.400000 1.000 1.000
0103015000 1CD Arrowroot, flour 0.040000 1.000 1.000
0103015001 1CD Arrowroot, flour

- babyfood 0.040000 1.000 1.000
0103017000 1CD Artichoke, Jerusalem 0.040000 1 .000 1.000

0103082000 1CD Cassava 0.040000 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.040000 1.000 1.000
0103139000 1CD Dasheen, corm 0.040000 1.000 1.000

0103166000 1CD Ginger 0.040000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.040000 1.000 1.000 0103167000 1CD Ginger, dried 0.040000 1.000 1.000 0103296000 1C Potato, chips 0.040000 1.000 0.200 0103297000 1C Potato, dry (granules/ flakes) 0.040000 1.000 0.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.040000 1.000 0.200
0103298000 1C Potato, flour 0.040000 1.000 0.200Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 26 of 39 0103298001 1C Potato, flour

- babyfood 0.040000 1.000 0.200 0103299000 1C Potato, tuber, w/peel 0.040000 1.000 0.200 0103299001 1C Potato, tuber, w/peel

- babyfood 0.040000 1.000 0.200

010330000 0 1C Potato, tuber, w/o peel 0.040000 1.000 0.200 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.040000 1.000 0.200 0103366000 1CD Sweet potato 0.040000 1.000 1.000 0103366001 1CD Sweet potato

- babyf ood 0.040000 1.000 1.000
0103371000 1CD Tanier, corm 0.040000 1.000 1.000

0103387000 1CD Turmeric 0.040000 1.000 1.000
0103406000 1CD Yam, true 0.040000 1.000 1.000

0103407000 1CD Yam bean 0.040000 1.000 1.000 0200051000 2 Beet, garden, tops 16.000000 1.000 1.000 0200101000 2 Chicory, tops 16.000000 1.000 1.000

0200140 000 2 Dasheen, leaves 16.000000 1.000 1.000 0200315000 2 Radish, tops 16.000000 1.000 1.000 0200317000 2 Radish, Oriental, tops 16.000000 1.000 1.000 0200332000 2 Salsify, tops 16.000000 1.000 1.000
0301165000 3A Garlic, bulb 0.900000 1.000 0.100
0301165001 3A Garlic, bulb

- babyfood 0.900000 1.000 0.100
0301237000 3A Onion, bulb 0.9000 00 1.000 0.250
0301237001 3A Onion, bulb

- babyfood 0.900000 1.000 0.250
0301238000 3A Onion, bulb, dried 0.900000 9.000 0.250
0301238001 3A Onion, bulb, dried

- babyfood 0.900000 9.000 0.250

03013 38000 3A Shallot, bulb 0.900000 1.000 1.000
0302103000 3B Chive, fresh leaves 25.000000 1.000 1.000

0302198000 3B Leek 0.900000 1.000 1.000 0302239000 3B Onion, green 0.900000 1.000 0.250
0302338500 3B Shallot, fresh leaves 0.900000 1.000 1.000 0401005000 4A Amaranth, leafy 11.770000 1.000 0.150 0401018000 4A Arugula 11.77 0000 1.000 1.000 0401104000 4A Chrysanthemum, garland 11.770000 1.000 1.000 0401133000 4A Cress, garden 11.770000 1.000 1.000 0401134000 4A Cress, upland 11.770000 1.000 1.000

040 1138000 4A Dandelion, leaves 11.770000 1.000 1.000

0401150000 4A Endive 11.770000 1.000 1.000
0401204000 4A Lettuce, head 0.590000 1.000 0.050
0401205000 4A Lettuce, lea f 7.680000 1.000 0.050 0401248000 4A Parsley, leaves 11.770000 1.000 1.000

0401313000 4A Radicchio 0.590000 1.000 1.000 0401355000 4A Spinach 11. 770000 1.000 0.050 0401355001 4A Spinach

- babyfood 11.770000 1.000 0.050

0402076000 4B Cardoon 5.020000 1.000 1.000 0402085000 4B Celery 5.020000 1.000 0.025

0 402085001 4B Celery

- babyfood 5.020000 1.000 0.025 0402086000 4B Celery, juice 5.020000 1.000 0.025

0402087000 4B Celtuce 5.020000 1.000 1.000
0402152000 4B Fennel, Fl orence 5.020000 1.000 1.000

0402322000 4B Rhubarb 5.020000 1.000 1.000

0402367000 4B Swiss chard 5.020000 1.000 1.000

0501061000 5A Broccoli 1.100000 1.000 0.050

0501061001 5A Broccoli

- babyfood 1.100000 1.000 0.050
0501062000 5A Broccoli, Chinese 5.000000 1.000 1.000 0501064000 5A Brussels sprouts 5.000000 1.000 1.000 0501069000 5A Cabbage 5.000000 1.000 0.100Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 27 of 39 0501071000 5A Cabbage, Chinese, napa 5.000000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 5.000000 1.000 1.000

0501083000 5A Cauliflo wer 5.000000 1.000 0.025

0501196000 5A Kohlrabi 5.000000 1.000 1.000

0502063000 5B Broccoli raab 16.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 16.000000 1.000 1.000

0502117000 5B Collards 5.740000 1.000 1.000

0502194000 5B Kale 16.000000 1.000 1.000 0502229000 5B Mustard greens 5.740000 1.000 1.000 0502318000 5B Rape greens 16.000000 1.000 1.000 0502389000 5B Turnip, greens 16.000000 1.000 1.000 0600347000 6 Soybean, seed 0.040000 1.000 0.050 0600349000 6 Soybea n, soy milk 0.040000 1.000 0.050 0600349001 6 Soybean, soy milk

- babyfood or in 0.040000 1.000 0.050 0600350000 6 Soybean, oil 0.040000 1.000 0.050 0600350001 6 Soybean, oil

- babyfood 0.040000 1.000 0.050 0601043000 6A Bean, snap, succulent 0.500000 1.000 0.025 0601043001 6A Bean, snap, succulent

- babyfood 0.500000 1.000 0.025 0601257000 6A Pea, edible podded, succulent 0.500000 1.000 1.0 00 0601349500 6AB Soybean, vegetable 0.500000 1.000 1.000
0602031000 6B Bean, broad, succulent 0.500000 1.000 0.025 0602033000 6B Bean, cowpea, succulent 0.500000 1.000 0.025

0602037000 6B Bean , lima, succulent 0.500000 1.000 0.025
0602255000 6B Pea, succulent 0.200000 1.000 0.050
0602255001 6B Pea, succulent

- babyfood 0.200000 1.000 0.050 0602259000 6B Pea, pigeon, succulent 0.200000 1.000 0.050
0603030000 6C Bean, black, seed 0.500000 1.000 0.100
0603032000 6C Bean, broad, seed 0.500000 1.000 0.100 0603034000 6C Bean, cowpea, seed 0.500000 1.000 0 .100 0603035000 6C Bean, great northern, seed 0.500000 1.000 0.100 0603036000 6C Bean, kidney, seed 0.500000 1.000 0.100
0603038000 6C Bean, lima, seed 0.500000 1.000 0.100

0603039000 6C Be an, mung, seed 0.500000 1.000 0.100 0603040000 6C Bean, navy, seed 0.500000 1.000 0.100 0603041000 6C Bean, pink, seed 0.500000 1.000 0.100 0603042000 6C Bean, pinto, seed 0.050000 1.000 0.100 0603098000 6C Chickpea, seed 0.340000 1.000 0.100 0603098001 6C Chickpea, seed

- babyfood 0.340000 1.000 0.100 0603099000 6C Chickpea, flour 0.340000 1.000 0.100
0603182000 6C Guar, seed 0.500000 1.000 0.100
0603182001 6C Guar, seed

- babyfood 0.500000 1.000 0.100
0603203000 6C Lentil, seed 0.500000 1.000 0.100

0603256000 6C Pea, dry 0.500000 1.000 0.100 0603256001 6C Pea, dry

- babyfood 0.500000 1.000 0.100 0603258000 6C Pea, pigeon, seed 0.500000 1.000 0.100 0603348000 6C Soybean, flour 0.040000 1.000 0.050 0603348001 6C Soybean, flour

- babyfood 0.040000 1.000 0.050

0801374000 8A Tomatillo 0.158000 1.000 1.000

0801375000 8A Tomato 0.158000 1.00 0 0.250

0801375001 8A Tomato

- babyfood 0.158000 1.000 0.250 0801376000 8A Tomato, paste 0.158000 2.100 0.250 0801376001 8A Tomato, paste

- babyfood 0.158000 2.100 0.250

0801377000 8A Tomato, puree 0.158000 0.550 0.250 0801377001 8A Tomato, puree

- babyfood 0.158000 0.550 0.250Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 28 of 39 0801378000 8A Tomato, dried 0.158000 14.300 0.250
0801378001 8A Tomato, dried

- babyfood 0.158000 14.300 0.250 0801379000 8A Tomato, juice 0.158000 1.500 0.250
0801380000 8A Tomato, Tree 0.158000 1.000 0.250 0802148000 8BC Eggplant 1.400000 1. 000 1.000

0802234000 8BC Okra 1.400000 1.000 1.000 0802270000 8B Pepper, bell 1.400000 1.000 0.100 0802270001 8B Pepper, bell

- babyfood 1.400000 1.000 0.100

0802271000 8 B Pepper, bell, dried 1.400000 1.000 0.100 0802271001 8B Pepper, bell, dried

- babyfood 1.400000 1.000 0.100 0802272000 8BC Pepper, nonbell 1.400000 1.000 0.100 0802272001 8BC Pepper, nonbell

- babyf ood 1.400000 1.000 0.100 0802273000 8BC Pepper, nonbell, dried 1.400000 1.000 0.100 0901075000 9A Cantaloupe 0.500000 1.000 0.150 0901187000 9A Honeydew melon 0.500000 1.000 1.000

0901399000 9A Watermelon 0.500000 1.000 0.300 0901400000 9A Watermelon, juice 0.500000 1.000 0.300 0902021000 9B Balsam pear 0.500000 1.000 1.000

0902088000 9B Chayote, fruit 0.500000 1.000 1.000 0902102000 9B Chinese waxgourd 0.500000 1.000 1.000

0902135000 9B Cucumber 0.500000 1.000 0.100 0902308000 9B Pumpkin 0.500000 1.000 0.200 0902309000 9B Pumpkin, seed 0.500000 1.000 0.200 0902356000 9B Squash, summer 0.500000 1.000 0.150 0902356001 9B Squash, summer

- babyfood 0.500000 1.000 0.150 0902357000 9B Squash, winter 0.500000 1.000 0.150 0902357001 9B Squash, winter

- babyfood 0.500000 1.000 0.150

1001106000 10A Citron 2.000000 1.000 1.000

10011070 00 10A Citrus hybrids 2.000000 1.000 1.000
1001108000 10A Citrus, oil 9.000000 1.000 1.000 1001240000 10A Orange 0.300000 1.000 0.050 1001241000 10A Orange, juice 0.300000 0.020 0.050 1001241001 10A Orange, juice

- babyfood 0.300000 0.020 0.050 1001242000 10A Orange, peel 0.300000 1.000 0.050 1001369000 10A Tangerine 2.00000 0 1.000 0.100 1001370000 10A Tangerine, juice 2.000000 0.020 0.100 1002197000 10B Kumquat 2.000000 1.000 1.000

1002199000 10B Lemon 2.000000 1.000 0.025

100220 0000 10B Lemon, juice 2.000000 0.020 0.025 1002200001 10B Lemon, juice

- babyfood 2.000000 0.020 0.025 1002201000 10B Lemon, peel 2.000000 1.000 0.025

1002206000 10B Lime 2.000000 1.000 1.000 1002207000 10B Lime, juice 2.000000 0.020 1.000 1002207001 10B Lime, juice

- babyfood 2.000000 0.020 1.000 1003180000 10C Grapefruit 2.000 000 1.000 0.300 1003181000 10C Grapefruit, juice 2.000000 0.020 0.300

1003307000 10C Pummelo 2.000000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.310000 1.000 0.150

1100 008000 11 Apple, peeled fruit 0.310000 1.000 0.150 1100008001 11 Apple, peeled fruit

- babyfood 0.310000 1.000 0.150 1100009000 11 Apple, dried 0.310000 8.000 0.150 1100009001 11 Apple, dried

- babyfood 0.310000 8.000 0.150 1100010000 11 Apple, juice 0.310000 0.200 0.150 1100010001 11 Apple, juice

- babyfood 0.310000 0.200 0.150Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 29 of 39 1100011000 11 Apple, sauce 0.3 10000 1.000 0.150 1100011001 11 Apple, sauce

- babyfood 0.310000 1.000 0.150 1100129000 11 Crabapple 1.500000 1.000 1.000 1100173500 11 Goji berry 1.500000 1.000 1.000

11 00210000 11 Loquat 1.500000 1.000 1.000

1100266000 11 Pear 1.500000 1.000 0.150

1100266001 11 Pear

- babyfood 1.500000 1.000 0.150
1100267000 11 Pear, dried 1.500000 6.250 0.150 1100268000 11 Pear, juice 1.500000 1.000 0.150 1100268001 11 Pear, juice

- babyfood 1.500000 1.000 0.150
1100310000 11 Quince 1 .500000 1.000 1.000 1201090000 12A Cherry 0.846000 1.000 0.500 1201090001 12A Cherry

- babyfood 0.846000 1.000 0.500 1201091000 12A Cherry, juice 0.846000 1.500 0.500 1201091001 12A Cherry, juice

- babyfood 0.846000 1.500 0.500 1202012000 12B Apricot 0.602000 1.000 0.250 1202012001 12B Apricot

- babyfood 0.602000 1.000 0.250 1202013000 12B Apricot, dried 0.602000 6.000 0.250 1202014000 12B Apricot, juice 0.602000 1.000 0.250 1202014001 12B Apricot, juice

- babyfood 0.602000 1.000 0.250

1202230000 12B Nectarine 0.602000 1.000 0.100

1202260000 12B Peach 0.602000 1.000 0.200

1202260001 12B Peach

- babyfood 0.602000 1.000 0.200
1202261000 12B Peach, dried 0.602000 7.000 0.200
1202261001 12B Peach, dried

- babyfood 0.602000 7.000 0.200 1202262000 12B Peach, juice 0.602000 1.000 0.200 1202262001 12B Peach, juice

- babyfood 0.602000 1.000 0.200

1203285000 12C Plum 0.198000 1.000 0.050

1203285001 12C Plum

- babyfood 0.198000 1.000 0.050 1203286000 12C Plum, prune, fresh 0.198000 1.000 0.050 1203286001 12C Plum, prune, fresh

- babyfood 0.198000 1.000 0.050 1203287000 12C Plum, prune, dried 0.198000 1.300 0.050 1203287001 12C Plum, prune, dried

- babyfood 0.198000 1.300 0.050 1203288000 12C Plum, prune, juice 0.198000 1.400 0.05 0 1203288001 12C Plum, prune, juice

- babyfood 0.198000 1.400 0.050 1301055000 13A Blackberry 4.000000 1.000 0.500 1301056000 13A Blackberry, juice 4.000000 1.000 0.500

1301056001 13A Black berry, juice

- babyfood 4.000000 1.000 0.500 1301058000 13A Boysenberry 4.000000 1.000 0.500 1301208000 13A Loganberry 4.000000 1.000 0.500 1301320000 13A Raspberry 4.000000 1.000 0.500 1301320001 13A Raspberry

- babyfood 4.000000 1.000 0.500 1301321000 13A Raspberry, juice 4.000000 1.000 0.500 1301321001 13A Raspberry, juice

- babyfood 4.000000 1.000 0. 500 1302057000 13B Blueberry 4.000000 1.000 0.450 1302057001 13B Blueberry

- babyfood 4.000000 1.000 0.450

1302136000 13B Currant 4.000000 1.000 1.000

1302137000 13B Cur rant, dried 4.000000 1.000 1.000 1302149000 13B Elderberry 4.000000 1.000 1.000 1302174000 13B Gooseberry 4.000000 1.000 1.000 1302191000 13B Huckleberry 4.000000 1.000 1.000 1303227000 13C Mulberry 4.000000 1.000 1.000 1304175000 13D Grape 0.768000 1.000 0.300 1304176000 13D Grape, juice 0.768000 0.010 0.300Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 30 of 39 1304176001 13D Grape, juice

- babyfood 0.768000 0.010 0.300 1304179000 13D Grape, wine and sherry 0.768000 1.000 0.300 1307359000 13G Strawberry 1.200000 1.000 0.650

1307359001 13G S trawberry

- babyfood 1.200000 1.000 0.650 1307360000 13G Strawberry, juice 1.200000 1.000 0.650 1307360001 13G Strawberry, juice

- babyfood 1.200000 1.000 0.650

1400003000 14 Almond 0.040000 1.000 0.400

1400003001 14 Almond

- babyfood 0.040000 1.000 0.400
1400004000 14 Almond, oil 0.040000 1.000 0.400
1400004001 14 Almond, oil

- babyfood 0.040000 1.000 0.400

1400059000 14 Brazil nut 0.040000 1.000 1.000

1400068000 14 Butternut 0.040000 1.000 1.000

1400081000 14 Cashew 0.040000 1.000 1.000

1400092000 14 Chestnut 0.040000 1.000 1.000

1400155000 14 Hazelnut 0.040000 1.000 0.200
1400156000 14 Hazelnut, oil 0.040000 1.000 0.200 1400185000 14 Hickory nut 0.040000 1.000 1.000

1400213000 14 Macadamia nut 0.040000 1.000 1.000

1400269000 14 Pecan 0.040000 1.000 0.025

1400278000 14 Pine nut 0.040000 1.0 00 1.000

1400282000 14 Pistachio 0.700000 1.000 0.300

1400391000 14 Walnut 0.040000 1.000 0.010 1500025000 15 Barley, pearled barley 1.400000 1.000 0.100

1500025001 15 Barley, pearled barley

- babyfood 1.400000 1.000 0.100 1500026000 15 Barley, flour 1.400000 1.000 0.100 1500026001 15 Barley, flour

- babyfood 1.400000 1.000 0.100 1500027000 15 Barley, bran 1.400000 1.000 0.100
1500120000 15 Corn, field, flour 0.100000 1.000 0.100
1500120001 15 Corn, field, flour

- babyfood 0.100000 1.000 0.100
1500121000 15 Corn, field, meal 0.100000 1 .000 0.100
1500121001 15 Corn, field, meal

- babyfood 0.100000 1.000 0.100
1500122000 15 Corn, field, bran 0.100000 1.000 0.100
1500123000 15 Corn, field, starch 0.100000 1.000 0.100

1500123001 15 Corn, field, starch

- babyfood 0.100000 1.000 0.100 1500124000 15 Corn, field, syrup 0.100000 1.500 0.100 1500124001 15 Corn, field, syrup

- babyfood 0.100000 1.500 0.100
1500125000 15 Corn, field, oil 0.200000 1.000 0.100
1500125001 15 Corn, field, oil

- babyfood 0.200000 1.000 0.100 1500126000 15 Corn, pop 0.100000 1.000 0.100
1500127000 15 Corn, sweet 0.040000 1.000 0.050
1500127001 15 Corn, sweet

- babyfood 0.040000 1.000 0.050 1500226000 15 Millet, grain 0.040000 1.000 1.000
1500231000 15 Oat, bran 1.200000 1.000 1.000

150023200 0 15 Oat, flour 1.200000 1.000 1.000
1500232001 15 Oat, flour

- babyfood 1.200000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 1.200000 1.000 1.000 1500233001 15 Oat, groats/rolled oats

- babyfood 1.200000 1.000 1.000 1500328000 15 Rye, grain 0.040000 1.000 1.000 1500329000 15 Rye, flour 0.040000 1.000 1.000 1500344000 15 Sorghum, grain 0.090000 1.000 1.000 1500345000 15 Sorghum, syrup 0.090000 1.000 1.000
1500381000 15 Triticale, flour 0.020000 0.700 1.000
1500381001 15 Triticale, flour

- babyfood 0.020000 1.000 1.000

1500401 000 15 Wheat, grain 0.020000 1.000 0.050Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 31 of 39 1500401001 15 Wheat, grain

- babyfood 0.020000 1.000 0.050
1500402000 15 Wheat, flour 0.020000 0.700 0.050
1500402001 15 Wheat, flour

- bab yfood 0.020000 0.700 0.050 1500403000 15 Wheat, germ 0.020000 0.850 0.050
1500404000 15 Wheat, bran 0.020000 1.000 0.050
1901028000 19A Basil, fresh leaves 40.0000 00 1.000 1.000
1901028001 19A Basil, fresh leaves

- babyfood 40.000000 1.000 1.000
1901029000 19A Basil, dried leaves 40.000000 1.000 1.000
1901029001 19A Basil, dried leaves

- babyfood 40.000000 1.000 1.000

19011 02500 19A Chive, dried leaves 40.000000 1.000 1.000
1901118000 19A Cilantro, leaves 40.000000 1.000 1.000
1901118001 19A Cilantro, leaves

- babyfood 40.000000 1.000 1.000

1901144000 19A Dillweed 40.000000 1.000 1.000
1901184000 19A Herbs, other 40.000000 1.000 1.000
1901184001 19A Herbs, other

- babyfood 40.000000 1.000 1.000 1901202000 19A Lemongrass 40.00 0000 1.000 1.000 1901220000 19A Marjoram 40.000000 1.000 1.000 1901220001 19A Marjoram

- babyfood 40.000000 1.000 1.000 1901249000 19A Parsley, dried leaves 40.000000 1.000 1.000

190 1249001 19A Parsley, dried leaves

- babyfood 40.000000 1.000 1.000 1901334000 19A Savory 40.000000 1.000 1.000
1902143000 19B Dill, seed 40.000000 1.000 1.000
2001163000 20A Flax seed, o il 0.450000 1.200 1.000 2001319000 20A Rapeseed, oil 0.450000 1.000 1.000 2001319001 20A Rapeseed, oil

- babyfood 0.450000 1.000 1.000
2001336000 20A Sesame, seed 0. 450000 1.000 1.000
2001336001 20A Sesame, seed

- babyfood 0.450000 1.000 1.000
2001337000 20A Sesame, oil 0.450000 1.000 1.000
2001337001 20A Sesame, oil

- babyfood 0.450000 1.000 1.000

2 002330000 20B Safflower, oil 0.450000 1.000 1.000
2002330001 20B Safflower, oil

- babyfood 0.450000 1.000 1.000
2002364000 20B Sunflower, seed 0.450000 1.000 1.000
2002365000 20B Sunflower, oil 0.450000 1.000 1.000
2002365001 20B Sunflower, oil

- babyfood 0.450000 1.000 1.000
2003114001 20C Coconut, oil

- babyfood 0.450000 1.000 1.000
2003128000 20C Cottonseed, oil 0.300000 1.000 0.025
2003128001 20C Cottonseed, oil

- babyfood 0.300000 1.000 0.025
3100044000 31 Beef, meat 0.100000 1.000 1.000
3100044001 31 Beef, meat

- babyfood 0.100000 1.000 1.000
3100045000 31 Beef, meat, dried 0.100000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 3100046001 31 Beef, meat byproducts

- babyfood 0.200000 1.000 1.000
3100047000 31 Beef, fa t 0.100000 1.000 1.000
3100047001 31 Beef, fat

- babyfood 0.100000 1.000 1.000 3100048000 31 Beef, kidney 0.200000 1.000 1.000
3100049000 31 Beef, liver 1.500000 1.000 1.000
3100049001 31 Beef, liver

- babyfood 1.500000 1.000 1.000
3200169000 32 Goat, meat 0.100000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000
3200171000 32 Goat, fat 0.100000 1.000 1.000 3200172000 32 Goat, kidney 0.200000 1.000 1.000
3200173000 32 Goat, liver 1.500000 1.000 1.000
3300189000 33 Horse, meat 0.100000 1.000 1.000
3400290000 34 Pork, meat 0.100000 1.000 1.000Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 32 of 39 3400290001 34 Pork, meat

- babyfood 0.100000 1.000 1.000
3400291000 34 Pork, skin 0.100000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.200000 1.000 1.000 3400292001 34 Pork, meat byproducts

- babyfood 0.200000 1.000 1.000
3400293000 34 Pork, fat 0.100000 1.000 1.0 00
3400293001 34 Pork, fat

- babyfood 0.100000 1.000 1.000 3400294000 34 Pork, kidney 0.200000 1.000 1.000
3400295000 34 Pork, liver 1.500000 1.000 1.000

3500339000 35 Shee p, meat 0.100000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.100000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 3500341000 35 Sheep, fat 0.100000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.100000 1.000 1.000 3500342000 35 Sheep, kidney 0.200000 1.000 1.000 3500343000 35 Sheep, liver 1.500000 1.000 1 .000
3600222000 36 Milk, fat 0.100000 1.000 1.000
3600222001 36 Milk, fat

- baby food/infant formu 0.100000 1.000 1.000
3600223000 36 Milk, nonfat solids 0.100000 1.000 1.000

3600223001 36 Mi lk, nonfat solids

- baby food/in 0.100000 1.000 1.000
3600224000 36 Milk, water 0.100000 1.000 1.000
3600224001 36 Milk, water

- babyfood/infant form 0.100000 1.000 1.000
3600225001 36 Milk, sugar (lactose)

- baby food/ 0.100000 1.000 1.000
4000093000 40 Chicken, meat 0.100000 1.000 1.000
4000093001 40 Chicken, meat

- babyfood 0.100000 1.000 1.000
4000094000 40 Chicken, liver 0.100000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.100000 1.000 1.000 4000095001 40 Chicken, meat byproducts

- babyfoo 0.100000 1.000 1.000
4000096000 40 Chicken, fat 0.100000 1.000 1.000

4000096001 40 Chicken, fat

- babyfood 0.100000 1.000 1.000
4000097000 40 Chicken, skin 0.100000 1.000 1.000
4000097001 40 Chicken, skin

- babyfood 0.100000 1.000 1.000 5000382000 50 Turkey, meat 0.100000 1.000 1.000 5000382001 50 Turkey, meat

- babyfood 0.100000 1.000 1.000 5000383000 50 Turkey, liver 0.100000 1.000 1.000 5000383001 50 Turkey, liver

- babyfood 0.100000 1.00 0 1.000 5000384000 50 Turkey, meat byproducts 0.100000 1.000 1.000 5000384001 50 Turkey, meat byproducts

- babyfood 0.100000 1.000 1.000 5000385000 50 Turkey, fat 0.100000 1.000 1.000

5000385001 50 Turkey, fat

- babyfood 0.100000 1.000 1.000 5000386000 50 Turkey, skin 0.100000 1.000 1.000 5000386001 50 Turkey, skin

- babyfood 0.100000 1.000 1.000 6000301000 60 Poultry, other, meat 0.100000 1.000 1.000 6000302000 60 Poultry, other, liver 0.100000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.100000 1.000 1.000 6000304000 60 Poultry, other, fat 0.100000 1. 000 1.000 6000305000 60 Poultry, other, skin 0.100000 1.000 1.000 7000145000 70 Egg, whole 0.100000 1.000 1.000 7000145001 70 Egg, whole

- babyfood 0.100000 1.000 1.000

7000146000 7 0 Egg, white 0.100000 1.000 1.000 7000146001 70 Egg, white (solids)

- babyfood 0.100000 1.000 1.000 7000147000 70 Egg, yolk 0.100000 1.000 1.000 7000147001 70 Egg, yolk

- babyfood 0.100000 1.000 1.000
8601000000 86A Water, direct, all sources 0.002300 1.000 1.000
8602000000 86B Water, indirect, all sources 0.002300 1.000 1.000Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 33 of 39 9500016000 O Artichoke, globe 0.840000 1.000 1.000

9500020000 O Avocado 0.600000 1.000 1.000

9500023000 O Banana 0.040000 1.000 1.000

9500023001 O Banana

- babyfood 0.040000 1.000 1.000

9500024000 O Banana, dried 0.040000 3.900 1.000
9500024001 O Banana, dried

- babyfood 0.040000 3.900 1.000 9500054000 O Belgium endive 0.820000 1.000 1.000

9500074000 O Canistel 0.600000 1.000 1.000
9500115000 O Coffee, roasted bean 0.064000 1.000 1.000
9500116000 O Coffee, instant 0.064000 1.000 1.000 9500177000 O Grape, leaves 0.768000 1.000 0.300 9500178000 O Grape, raisin 0.768000 1.000 0.300 9500188000 O Hop 23.000000 1.000 1.000 9500215000 O Mango 0.600000 1.000 1.000

95002150 01 O Mango

- babyfood 0.600000 1.000 1.000 9500216000 O Mango, dried 0.600000 1.000 1.000 9500217000 O Mango, juice 0.600000 1.000 1.000 9500217001 O Mango, juice

- baby food 0.600000 1.000 1.000 9500245000 O Papaya 0.600000 1.000 1.000 9500245001 O Papaya

- babyfood 0.600000 1.000 1.000 9500246000 O Papaya, dried 0.60000 0 1.800 1.000 9500247000 O Papaya, juice 0.600000 1.500 1.000

9500263000 O Peanut 0.050000 1.000 0.250
9500264000 O Peanut, butter 0.050000 1.890 0.250

950026 5000 O Peanut, oil 0.100000 1.000 0.250 9500275000 O Peppermint 8.000000 1.000 1.000 9500276000 O Peppermint, oil 8.000000 1.000 1.000

9500277000 O Persimmon 0.600000 1.000 1.000

9500283000 O Plantain 0.040000 1.000 1.000
9500284000 O Plantain, dried 0.040000 3.900 1.000 9500333000 O Sapote, Mamey 0.600 000 1.000 1.000 9500352000 O Spearmint 8.000000 1.000 1.000 9500353000 O Spearmint, oil 8.000000 1.000 1.000 9500362000 O Sugarcane, sugar 0.076000 0.150 1.000

9500 362001 O Sugarcane, sugar

- babyfood 0.076000 0.150 1.000 9500363000 O Sugarcane, molasses 0.076000 0.150 1.000 9500363001 O Sugarcane, molasses

- babyfood 0.076000 0.150 1.000Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

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Page 34 of 39 

### Attachment 5 . Pyraclos trobin Chronic Dietary Analysis Results

– Food & Water

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for PYRACLOSTROBIN NHANES 2003

- 2008 2

- day

Residue file name:

E: \ RAB3_2014 \ BoscalidPyra clo \ DEEM \ PyracloChronic07_17_14.R0 Adjustment factor #2 used. Analysis Date 07

- 17

- 2014/08:11:22 Residue file dated: 07

- 17

- 2014/08:07:45 Reference dose (RfD, Chronic) = .034 mg/kg bw/day

COMMENT 1: Food and drinking water

========================================================================== Total exposure by population subgroup

--------------------------------------------------------------------------

Total Exposure

--------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ------------- Total US Population 0.002742 8.1% Hispanic 0.002744 8.1%

Non

- Hisp

- White 0.002702 7.9%

Non

- Hisp

- Black 0.002734 8.0%

Non

- Hisp

- Other 0.003300 9.7% Nursing Infants 0.002378 7.0%

Non

- Nursing Infants 0.004844 14.2%

Female 13+ PREG 0.002267 6.7%

Children 1

- 6 0.007124 21.0%

Children 7

- 12 0.003291 9.7%

Male 13

- 19 0.002025 6.0%

Female 13

- 19/NP 0.001719 5.1%

Male 20+ 0.00 2364 7.0%
Female 20+/NP 0.002191 6.4%

Seniors 55+ 0.002223 6.5%

All Infants 0.004082 12.0%

Female 1 3

- 50 0.002049 6.0%

Children 1

- 2 0.009231 27.1%

Children 3

- 5 0.006258 18.4%

Children 6

- 12 0.003566 10.5%

Youth 13

- 19 0.001869 5.5%

Adults 20

- 49 0.002269 6.7%

Adults 50

- 99 0.002282 6.7%

Fe male 13

- 49 0.002049 6.0%

--------------------------------------------------------------------------Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 35 of 39 

### Attachment 6 . Pyraclostrobin Chronic Dietary Analysis Results

– Food

US E PA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for PYRACLOSTROBIN NHANES 2003

- 2008 2

- day

Residue file name:

E: \ RAB3_2014 \ BoscalidPyraclo \ DEEM \ PyracloChronic07_17_14_NOwater.R08 Adjustment factor #2 used. Analysis Date 07

- 17

- 2014/08:13:12 Residue file dated: 07

- 17

- 2014/08:08:55 Reference dose (RfD, Chronic) = .034 mg/kg bw/day

COMMENT 1: Food

========================================================================== Total exposure by population subgroup

--------------------------------------------------------------------------

Total Exposure

------------------ --------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ------------- Total US Po pulation 0.002694 7.9% Hispanic 0.002698 7.9%

Non

- Hisp

- White 0.002652 7.8%

Non

- Hisp

- Black 0 .002694 7.9%

Non

- Hisp

- Other 0.003245 9.5% Nursing Infants 0.002334 6.9%

Non

- Nursing Infants 0.004684 13.8%

Femal e 13+ PREG 0.002222 6.5%

Children 1

- 6 0.007063 20.8%

Children 7

- 12 0.003251 9.6%

Male 13

- 19 0.001992 5.9%

Female 13

- 19/NP 0.001682 4.9%

Male 20+ 0.002319 6.8% Female 20+/NP 0.002141 6.3%

Seniors 55+ 0.002177 6.4%

All Infants 0.003958 11.6%

Female 13

- 50 0.002001 5.9%

Children 1

- 2 0.009161 26.9%

Children 3

- 5 0.006200 18.2%

Children 6

- 12 0.003523 10.4%

Youth 13

- 19 0.001833 5.4%

Adults 20

- 49 0.002221 6.5%

Adults 50

- 99 0.002234 6.6%

Female 13

- 49 0.002001 5.9%

------------------------------------------------------------------------Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 36 of 39Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 37 of 39 

### Attachment 7 . Pyraclostrobin Screening Level Usage Analysis (SLUA)Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 38 of 39Pyraclostrobin Dietary Exposure and Risk Assessment DP Number: 4 21148

_________ __________________________________________________________________________

Page 39 of 39