### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460



### MEMORANDUM

Date: 03/02/2016 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION



### SUBJECT: Bensulide. Acute and Steady State Probabilistic Aggregate Dietary (Food Only

, Water Only

, and Food and Drinking Water) Exposure and Risk Assessments for Registration Review Risk Assessment.



### PC Code: 009801 

### Decision No.: 507866 

### Petition No.: NA 

### Risk Assessment Type: Dietary 

### TXRNo.: NA 

### MRIDNo.: NA 

### DP Barcode: D428878 

### Registration No.: 10163-200 

### Regulatory Action: Registration Review 

### CaseNo.: NA 

### CAS No.: 741-58-2 40 

### CFR: § 180.241



### FROM: ldeliz Negron-Encarnacion, Ph.D.

, Chemist

# ~----- Risk Assessment Branch V ' 

# '7

Health Effects Division (HED; 7509P)



### THROUGH: DanetteDrew

, Chemist(RABV;HED)

# ~
Nancy 

### Dodd,

# ~!mist .

# / /L 17 

# fl}.,

# ~ William Cutchin

, Chemist

# %~**~** Dietary Exposure Science Advisory Council (DESAC)



### TO: Margaret Hathaway 

### I Kevin Costello Pesticide Re-evaluation Division (7508P)



### Executive Summary

Acute and steady state aggregate dietary (food only

, water only, and food and drinking water)

exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16. This software

uses 2003-2008 food consumption data from the U.S. Department of Agriculture ' s (USDA's) National Health and Nutrition Examination Survey, What We Eat in America

, (NHANES/WWEIA). The analyses were conducted in support of the registration review risk

Page 1 of 47Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 2 of 47 

### assessment. This memorandum was reviewed by two peer reviewers of the DESAC (and the entire DESAC on 10-08-2015), per DESAC Sta ndard Operating Procedure (SOP) 2012.1.

Acute and steady state dietary exposure assessmen ts incorporated USDA Pe sticide Data Program (PDP) monitoring data for bensulide and its oxon (w hen available), anticipat ed residues, default DEEM processing factors, and pe rcent crop treated (CT). Based on the absence of a comparative cholinesterase assay (CCA) with bensulide and its oxon, a toxicity adjustment factor (TAF) of 50x was applied, assuming that the oxon analog is mo re toxic than bensulide. This toxicity adjustment factor was applied to residues of the oxon analog in food commodities and drinking water. The Environmental Fate and Effects Division (EFED) pr ovided daily time series outputs for the scenario that provide the highest and lowest estimated drinking water concentrations (EDWCs). The highest EDWC was for groundwater in North Carolina East ern Coastal Plain (NC Cotton). The drinking water distributions for ground water assume that 13.8% of bensulide applied is converted to its oxon. This assumpti on is based on the aerobic soil metabolism study, the study that provided the maximum conversion to the oxon. The scenario that provided the lowest EDWC was surface water in California (CA A vocado). It is assumed that all bensulide in surface water is transformed to the oxon during chlorination.

Acute Dietary Exposure Assessment

Acute assessments were conducted for food only, a nd food and drinking water. The acute dietary exposure estimates from food alone are below HE D’s level of concern (<100 % of the acute population adjusted dose (aPAD)) at the 99.9 th 

### percentile of exposure. Bensulide food only dietary exposure estimate is 46% of the aP AD for children 3-5 years old, the most highly exposed population subgroup, and 31% of the aPAD for the gene ral population. Exposures are above the level of concern (L OC) for drinking water only. For food and drinking water, the dietary exposure is above HED’ s LOC using drinking water scenar ios that provided the highest and lowest EDWC, i.e. dietary exposure estim ates were >10,000% and >1,600% of the aPAD at the 99.9 th 

### percentile of exposure for the general population and most popul ation subgroups using the NC Cotton and CA Avocado scenarios, resp ectively. Although for Adults 50-99 years old the FQPA SF is 1x, exposures were above the LO C for food and drinking water as well.

Steady State Dietary Exposure Assessment

Organophosphates (OPs) may exhibit a phenomenon know n as steady state acetylcholinesterase (AChE) inhibition which is the most sensitive en dpoint for all lifestages. After repeated dosing at the same dose, the amount of AChE inhibiti on in a given dose remains consistent across duration. For this reason, a steady-state point of departure (PoD) was selected for oral exposure to bensulide.

Steady state assessments were conducted for f ood only, and food and drinking water. The steady state dietary exposure estimates from food al one are below HED’s LOC (<100 % of the steady state population adjusted dose (ssPAD) at the 99.9 th 

### percentile of exposure for the general population and all population subgro ups. Bensulide food only dietary risk is 80% of the ssPAD for children 3-5 years old, the most highly e xposed population subgroup, and 58% of the ssPAD for the general population. Exposures are above the level of concern for drinking water only.Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 3 of 47 

### For food and drinking water, the dietary exposur e is above HED’s LOC using drinking water scenarios that provided the highest and lowest EDWC, i.e. dietary exposure estimates were >10,000% and >2,900% of the ssPAD at the 99.9 th 

### percentile of exposure for the general population and most population s ubgroups using the NC Cotton and CA Avocado scenarios, respectively. Although for Adults 50-99 years ol d the FQPA SF is 1x, exposures were above the LOC for food and drinking water as well.

Overall, the dietary assessments could be refined if a CCA study were available to establish a TAF for the oxon. Additional fate data would be needed to further refine the drinking water assessment; refer to EFED memo.

I. Introduction

Dietary risk assessment incorporat es both exposure and toxicity of a given pesticide. For acute and steady state assessments, the risk is expresse d as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population-adjust ed dose (PAD). The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and steady state exposures, HED is c oncerned when estimated dietary risk exceeds 100% of the PAD. References that discuss th e acute risk assessments in more detail are available on the EPA/pesticides web site: “A vailable Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.regulations.gov/#!docum entDetail;D=EPA-HQ-OPP-2007-0780-0001 ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for bensulide was conducted by C. Swartz (05/28/1999, D256307).

II. Residue Information

Residues of Concern

The nature of the residues in plants is adequate ly established based on ca rrot, lettuce and tomato metabolism studies. The residues of concern for risk assessment in plants and drinking water and tolerance enforcement in plants consists of bensulide and its oxon (C. Eiden, D238417, 10/06/1997).

Table 1. Summary of Metabolites and Degradates to be included in the Risk Assessment and Tolerance Expression

Matrix Residues included in Risk Assessment Residues included in Tolerance Expression

Plants Primary Crop Bensulide and its oxon Bensulide and its oxon Rotational Crop NS 1 

### NS 1



### Livestock Ruminant NR 1 

### NR 1 

### PoultryBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 4 of 47 

### Table 1. Summary of Metabolites and Degradates to be included in the Risk Assessment and Tolerance Expression

Matrix Residues included in Risk Assessment Residues included in Tolerance Expression Drinking Water Bensulide and its oxon Not Applicable

1 NS = Not specified. It was indicated that the nature of th e residue seems to be similar to that on primary crops (C. Eiden, D218575, 04/02/1997). Following the 120-day plant-back interval (PBI), residues in rotational crops do not need to be considered for risk asse ssment and tolerance enforcement.

2 NR = Not required to support the established uses of bensulide. Livestock metabolism studies may be required if new uses are sought.



### Tolerances

Tolerances are established in the 40 CFR § 180. 241 for the use of bensulide on bulb onion, leafy brassica vegetables (crop group (C G) 5), cucurbit vegetables (C G 9), fruiting vegetable (CG 8), leafy vegetable except brassica (CG 4), and carrots . These tolerances are based on measurement of bensulide and its oxon and range from 0.10 to 0.15 ppm. The 0.10 ppm tolerances are based on combined levels of bensulide and its oxon at the limit of quantitation (LOQ) of 0.05 ppm. However, in order to account fo r potential residue losse s during storage prior to analysis, the tolerance for bensulide residues on brassica vegeta bles (CG 5), cucurbit vegetables (CG 9) and leafy vegetables (CG 4) is 0.15 ppm (based on twice the limit of quantitation for bensulide per se (0.10 ppm) plus the limit of quantifica tion for bensulide oxon (0.05 ppm)).

Relative Toxicity of the Oxon

In order to account for the relativ e toxicity of bensulide oxon with respect to parent bensulide, a CCA study is needed. EPA plans to move forwar d with bensulide human health risk assessment without toxicity data for bens ulide’s oxon degradate. In lieu of bensulide-specific oxon CCA data, EPA will use an oxon toxicity adjustment factor of 50x in its calculations. This value considers the data derived toxicity adjustment factor EPA has identified among oxon metabolites for other organophosphates, with an additional margin of safety included due to the uncertainty in extrapolating oxon potency data across chemicals.

Anticipated Residues

In general, USDA Pesticide Data Program (PDP ) monitoring data were incorporated in the dietary assessment. When the commodity was no t analyzed by the USDA PDP or translations were not possible, tolerance-leve l residues were used. Anticipated residues using tolerances are based on the LOQ or 2 times the LOQ (due to storag e stability issues with parent bensulide) of the data acquisition method. The TAF of 50x was applied to th e LOQ of the oxon.

The PDP was specifically designed for risk asse ssment; analysts prepare samples in a manner similar to typical consumer practices, such as washing, coring, and peeling. Previous dietary assessments for bensulide have used Food and Drug Administration (FDA) surveillance data; however, these data are considerably older than th e available PDP data, and were not used in this assessment. If monitoring data were not availa ble for a particular commodity (i.e. cabbage), but were available for a similar commodity (head lettuce), the available data were translated to the similar crop (HED SOP 99.3) with si milar use patterns. When data were translated, the residueBensulide Dietary Exposure and Risk Assessment DP Number: D428878

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### distribution file (RDF) was adjusted to account fo r differences in percent crop treated. All RDFs were adjusted to account for the oxon analog TA F of 50x (See Table 2 below). Attachment A.1.2 summarizes the residue inputs (anticipated residues, processi ng factors, PCT, etc.) for the acute and steady state assessments. Attachment A.1.3 summarizes all of the RDF files used for the acute and steady state assessments.

In years 2010 to 2013, USDA PDP analyzed severa l commodities for residues of bensulide and its oxon separately. PDP monitoring data is av ailable for residues of bensulide and its oxon in carrots, carrots baby food, summer squash, cherry to matoes, and lettuce. PDP monitoring data is only available for parent bensulide for celery, winter squash, hot peppers, onion, canned spinach and frozen spinach. When both residues of concer n were analyzed, the re sidues of bensulide and oxon were combined using a Statistical Analysis System (SAS) program that matches residues from the same samples using the PDP sample IDs. The SAS program adjusted the residues of the oxon analog using the TAF of 50x, and then added the adjusted oxon residue with the bensulide residue from the same sample. The SA S program directly created the RDFs for use in the acute and two-day average analyses. When only parent bensulide was analyzed, the RDFs were modified to account for the oxon analog.

In some cases, residues of either bensulide or it s oxon may have not been detected or the samples may not have been analyzed for both residues. Th e set of rules outlined in Table 2 were used to combine the residues for each sample. When th e oxon analog was not measured, concentration adjustment factors of 1x or 9x were used, depe nding on the likelihood of having similar or higher residues to parent bensulide in a given commodit y. A 9x factor was used for spinach and celery; refer to Attachment 1 for a detailed discussion.

Table 2. Method for Combining Residues of Bensulide and its Oxon from the Same PDP Sample. Bensulide Oxon Analog Data Treatment 1,2

detect detect Bensulide detect + (50x) Oxon detect

detect non-detect Bensulide detect + (50x) 1⁄2 LOD for Oxon for that sample

non-detect detect 1⁄2 LOD for Bensulide for that sample + (50x) Oxon detect

non-detect non-detect Highest 1⁄2 LOD for Bensulide + (50x) highest 1⁄2 LOD for Oxon

detect not-analyzed detect for Bensulide + (50x) (9x) 3 Highest 1⁄2 LOD for Bensulide

non-detect not-analyzed Highest 1⁄2 LOD for Bensulide + (50x) (9x) 3 Highest 1⁄2 LOD for Bensulide

1 The acute and steady state assessments use the acute TAF of 50x.

2 The highest limit of detection (LOD) for bensulide or its oxon was used to estimate the LOD to be included in the RDF file or used in point estimate calculations. When be nsulide or its oxon was not detected, the LOD of that sample was used and added to the concentration of the anal yte that was detected. When the oxon was not analyzed, the LOD of bensulide was used because generally the LOD of the oxon is similar than that of bensulide.

3 When the oxon was not measured, a relative concentration factor of 1x or 9x was applied to convert bensulide concentration to its oxon. The 9x factor was only applied to leafy vegetables (i.e. spinach and celery) since in these commodities the oxon is likely to have a higher concentration than parent bensulide.Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

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### Processing Factors

DEEM default processing factors were used for all processed commodities as available.

Residues in Fish

The USDA Pesticide Data Program (PDP) monito red pesticide residues in catfish in 2008, 2009, and 2010. In general, pesticide residues would not be expected to be found in fish unless the pesticide bio accumulates or has an aquatic use. To determine whether or not residues are present in fish, HED now routinely checks PDP monitoring data regardle ss of the pesticide’s uses and physicochemical properties. Howeve r, PDP did not analyze catfish samples for bensulide. The PDP did monitor pesticide residu es in salmon in 2013. Over this 1-year period, PDP analyzed 235 samples of salmon for residue s of bensulide and it s oxon. None of the samples contained detectable residues. As a re sult, residues in fish were not included in the

assessment.

III. Percent Crop Treated Information

The following maximum percent crop treated estimates (Updated Screening Level Usage Analysis Report for Bensulide, PC Code 009801; 07/10/2015) were used in the acute and steady state dietary risk assessment for the following crops that are currently registered for bensulide: broccoli: 25%; brussel sprouts: 5%; cabbage: 20 %; cantaloupes: 40%; cauliflower: 20%; celery: 5%; cucumbers: 5%; honeydews: 30%; lettu ce: 40%; onions: 20%; peppers: 10%; pumpkins: 10%; spinach: 10%; squash: 15%; and watermelons : 10%. Percent of cr op treated estimates were not provided for carrot, tomato, eggplant, okra and several non-representative crops under the cucurbit, leafy and brassica vegetables. 100 % of crop treated were assumed for these crops.

IV. Drinking Water Data

The drinking water residues used in the di etary risk assessment were provided by the Environmental Fate and Effect s Division (EFED) in the following memorandum: “Bensulide: Drinking Water Exposure Assessment fo r Registration Review” (D428601, He Zhong, 09/14/2015) and incorporated directly into this dietary assessment. Water residues were incorporated in the DEEM-FCID into the food cat egories “water, direct, all sources” and “water, indirect, all sources.”

Drinking water from surface water sources ma y be subjected to water treatment through chlorination. Kamel et al. (2009) demonstrated that the parent bensulide residues may be totally converted into bensulide oxon during chlorination processes. Therefore, a total toxic residue (TTR) approach based on the oxon equivalent wa s used for drinking water from surface water sources. The recommended estimated drinking water concentrations (EDWCs) of the TTRs from surface water sources were generated with the Surface Water Concentration Calculator (SWCC) model from the use scenario of the ma ximum exposure, California lettuce, with three ground spray applications at 6 lb ai/A each a nd a minimum 4-month interval (Table 3).Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 7 of 47 

### Drinking water from groundwater sources is seldom subjected to chlorination; thus, conversion of bensulide to its oxon was only based on aerobic soil metabolism processes (13.8%). Therefore, recommended oxon EDWCs from groundw ater sources were modeled with PRZMGW based on the oxon soil conversion rate at 2.12 lbs ai /A following the use scenario on loamy sand soil in NC eastern coastal plain with two bensulide maximum granular applications at 16 lbs ai/A each at a 4-month interval (Table 3). Note that the EDWCs for groundwater were also obtained by modeling bensulide at the maximum applicati on rate; however, the EDWCs recommended by EFED are based on the oxon since these were higher th an those for parent bensulide.

Table 3. Recommended Surface Water and Groundwater EDWCs ( μ g/L) for Bensulide Oxon Surface Water Model: Tier II SWCC (v 1.106) 1 in 10 yr Peak 1 in 10 yr Annual Average 30 yr Annual Average Ground Spray - CA Lettuce scenario (W23273.dvf) (6 lbs ai/acre for 3 app lications (2/1, 6/1, 10/1) 979 494 305

Groundwater Model: Tier 1 PRZM-GW 1
Peak Values Post Breakthrough Average Breakthrough Time (Days) NC Eastern Coastal Plain - (w13722Extended.dvf) 2.12 lbs ai/acre for 2 applications (3/1 and 7/1) 1,250 1,200 7,106

1 The peak for parent bensulide is 48.8 μg/L. Since this concentration is significantly lower than the peak concentration modeled for the oxon (even more after considering the 50x). The concentration of parent bensulide was not added to that for the oxon.



### Based on modeling, the highest residues were obtained for groundwater. In addition, the scenario that provided the lowest EDWC (California Avocado; 3 a pplications at 6 lbs ai/A) was modeled to provide the lowest es timate of the exposure and risk for food and drinking water; see Table 4.

Table 4. Surface Water EDWCs for Bensulide TTRs
Scenario Application Method Single Application Rate (lbs ai/acre) No. and Date(mm/dd) of Applications Concentration (μg/L) 1 in 10

yr Peak 1 in 10 yr Annual Average 30 year annual

average

CA Avocado (W23188.dvf) Ground Spray 6 3 and (2/1, 6/1, 10/1) 179 100 73



### For the acute and steady state assessments, the entire 30-year distributio n of estimated daily concentrations in groundwater was incorporated into DEEM-FCID and used in the probabilistic analyses. For steady state the daily time seri es were recalculated using the 21-day rolling averages. In the 21-day rolling aver age distributions, the first data point is the average of days 1- 21, the second data point is the average of days 2- 22, the third data point is the average of days 3-23, etc. Both the acute and steady state dietary asse ssments, the water residues distribution were incorporated in the DEEM-FCID into the food cat egories “water, direct, all sources” and “water, indirect, all sources.” The model and its descri ption are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/

.Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 8 of 47 

### V. DEEM-FCID Program and Consumption Information

Bensulide’s acute and steady stat e (acute 2-day average) dietary exposure assessments were conducted using the DEEM-FCID, Version 3.1 6, which incorporates 2003-2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non-consecu tive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fres h or N/S, baked) using publicly available recipe translation files developed jo intly by USDA/ARS and EPA. For acute exposure assessment, consumption data are retained as individual cons umption events. Based on analysis of the 2003- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to re port risk for the following population subgroups: the general U.S. population, all infants (< 1 year old), children 1-2, children 3-5, children 6-12, yout h 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For an acute exposure assessment, individual one -day food consumption data are used on an individual-by-individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reporte d eating the relevant commodities as well as those who did not) basi s. In accordance with HED policy, per capita exposure and risk are reported for analyses performe d at all levels of refinement. However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and not ed in the risk assessment.

For a two-day average exposure assessment, two- day average food consumptions are calculated on an individual-by-individual basis. The re ported consumption amounts of each food item for each day are added together and then divided by two days. For example, if an individual reports eating 100 grams of apple on the first day and 0 grams of apple on the second day, the two-day average consumption amount would be 50 grams/da y of apple [(100 grams + 0 grams)/2 days = 50 grams/day]. The resulting two-day average consumption amount can then be multiplied by a residue point estimate and summed to obtain a to tal daily pesticide expos ure for a deterministic exposure assessment, or “matched” in multiple ra ndom pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the ssPAD on both a user (i.e ., only those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who re ported eating the relevant commodities as well as those who did not) basi s. In accordance with HED policy, per capita exposure and risk are reported for analyses performe d at all levels of refinement. However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and not ed in the risk assessment.

The steady state (two-day average) assessmen ts were conducted in the DEEM acute module using the steady state endpoint and 21-day forward -rolling water averages to provide an estimateBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 9 of 47 

### of 21-day (“steady state”) aver age daily exposures. These steady state assessments were completed for drinking water alone, food alone, a nd food and drinking water. For drinking water alone, the two-day average assessments, using a 21-day forward-rolling average water file, provide an accurate overall estimat e of the 21-day (“steady state”) average daily exposures at the per capita 95 th 

### or 99.9 th 

### percentile for drinking water, to the extent that predicted drinking water concentrations for any 21-day duration is known for any given year. For food alone, the steady state assessments reflect an average daily exposu re for a two-day exposure duration rather than a 21-day exposure duration. Since the DEEM stea dy state (two-day average assessment) does not capture day to day variation in food residues, it will generally result in higher food-only exposure estimates than a model that calculates 21-day rolling aver ages for food.

VI. Toxicological Information

Bensulide is a member of the organophosphate (OP) class of pesticides. Like other OPs, the initiating event in the adverse outcome pathwa y (AOP)/ mode of action (MOA) for bensulide involves inhibition of the enzyme acetylcholineste rase (AChE) via phosphorylation of the serine residue at the active site of th e enzyme. This inhibition leads to accumulation of acetylcholine and ultimately to neurotoxicity in the central an d/or peripheral nervous system. For bensulide, AChE inhibition is the most sens itive endpoint in the toxicology database in multiple species, durations, lifestages, and rout es. OPs also exhibit a phenomen on known as steady-state AChE inhibition. After repeated dosing at the same dos e level, the degree of inhibition comes into equilibrium with the production of new, uninhibited enzyme.

EPA plans to move forward with bensulide human health risk assessment without toxicity data for bensulide’s oxon degradate. In lieu of bens ulide-specific oxon CCA data, EPA will use an oxon toxicity adjustment factor of 50x in its calculations. This value considers the data derived toxicity adjustment factor EPA has identified among oxon metabolites for other organophosphates, with an additional margin of safety included due to the uncertainty in extrapolating oxon potency data across chemicals.

There is uncertainty in the hum an dose-response relationship for neurodevelopmental effects and this warrants retention of the FQPA Safety F actor for the population subgroups that include infants, children, youths, and women of childbearing age for all exposure sc enarios. Therefore, the dietary exposure results for the general U. S. Population and all population subgroups will include a 10x FQPA SF. Refer to the risk assessment for a discussion of the additional 10x SF due to the uncertainty in the epidemiology data.

Bensulide is not likely to be carcinogenic in humans via relevant routes of exposure.Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 10 of 47 Table 5. Summary of Toxicological Doses and Endpoints and Points of Departure for Bensulide in Dietary and Non-Occupational Human Health Risk Assessments a

Exposure Scenario Point of Departure (mg/kg/day) Uncertainty/FQPA Factors RFD, PAD, & LOC for Risk Assessment Study and Toxicological Effects
Acute Dietary

(All Populations Except Adults 50-99 Years) BMDL 10 = 11 mg/kg UF A = 10x UF H = 10x FQPA SF = 10x Acute RfD = aPAD = 0.011 mg/kg/day Acute CCA Study (MRID 49433502) in the rat BMD 10 = 16 mg/kg

Inhibition of RBC ChE in female pups (PND 11)

Acute Dietary

(Adults 50-99 Years) BMDL 10 = 11 mg/kg UF A = 10x UF H = 10x FQPA SF = 1x Acute RfD = aPAD = 0.11 mg/kg/day Acute CCA Study (MRID 49433502) in the rat BMD 10 = 16 mg/kg

Inhibition of RBC ChE in female pups (PND 11)

Steady-State Dietary

(All Populations Except Adults 50-99 Years) BMDL 10 = 6 mg/kg/day UF A = 10x UF H = 10x FQPA SF = 10x ssRfD = ssPAD = 0.006 mg/kg/day Repeated-Dose CCA Study (MRID 49466201) in the rat BMD 10 = 8 mg/kg/day

Inhibition of RBC ChE in male pups (PND 11 initially)

Steady-State Dietary

(Adults 50-99 Years) BMDL 10 = 6 mg/kg/day UF A = 10x UF H = 10x FQPA SF = 1x ssRfD = ssPAD = 0.06 mg/kg/day Repeated-Dose CCA Study (MRID 49466201) in the rat BMD 10 = 8 mg/kg/day

Inhibition of RBC ChE in male pups (PND 11 initially)

Cancer (oral, dermal, inhalation) Classification: Group E chemi cal – the chemical is not likely to be carcinogenic in humans

a Point of Departure (PoD) = A data point or an estimated poin t that is derived from observed dose-response data and used to mark the beginning of extrapolation to determine risk associated with lower en vironmentally relevant human exposures. BMDL = lower limit of the bench mark dose. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among member s of the human population (intraspecies). SF = Safety Factor. PAD = population adjusted dose (a = acute , c = chronic). RfD = refere nce dose. MOE = margin of exposure. LOC = level of concern. FQPA = Food Quality Protection Act

b This uncertainty factor incorporates uncertainty in the human dose-response relationship for neurodevelopmental effects (see Section 4.4) and because there is an unfulfilled inha lation study requirem ent for bensulide Toxicity adjustment factor to convert bensulide oxon to bensulide equivalents is 50 (oral).



### VII. Results/Discussion

As stated above, for acute and steady state a ssessment, HED is concer ned when dietary risk exceeds 100% of the PAD. The DEEM-FCID analys es estimate the dietary exposure and risk of the U.S. population and various pop ulation subgroups. The results reported in Tables 5-8 are forBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 11 of 47 

### the general U.S. Population, all infants (<1 year old), children 1-2, chil dren 3-5, children 6-12, youth 13-19, females 13-49, adults 20 -49, and adults 50-99 years.

Results of Acute Dietary (Food Only, and F ood and Drinking Water) Exposure and Risk Analysis

The results of the acute dietary exposure and risk analysis for food only at the 95 th 

### , 99 th 

### , and 99.9 th 

### percentiles of exposure are reporte d in Table 6 and those at the 99.9 th 

### percentile of exposure for food only and food and dri nking water are reported in Table 7.

Table 6. Results of Acute Dietary (Food Only) Exposure and Risk Analysis.

Population Subgroup aPAD (mg/kg/day) 95 th Percentile 99 th Percentile 99.9 th Percentile Exposure (mg/kg/day) % aPAD Exposure (mg/kg/day) % aPAD Exposure (mg/kg/day) % aPAD General U.S. Population

0.011 for All Except Adults 50-99

years old which used 0.11 0.000696 6.3 0.001359 12 0.003459 31 All Infants (<1 year old) 0.000877 8.0 0.002354 21 0.003299 30 Children 1-2 years old 0.001592 14 0.002775 25 0.004436 40 Children 3-5 years old * 0.001544 14 0.003278 30 0.005016 46 Children 6-12 years old 0.000991 9.0 0.001544 14 0.003835 35 Youth 13-19 years old 0.000570 5.2 0.001001 9.1 0.002713 25 Adults 20-49 years old 0.000585 5.3 0.001041 9.5 0.002241 20 Adults 50-99 years old 0.000545 < 1 0.001090 1.0 0.002124 1.9 Females 13-49 years old 0.000588 5.4 0.001031 9.4 0.002685 24 * The subpopulation (with exception of Adults 50-99 years old) with the highest risk estimate is bolded.



### Table 7. Summary of Acute Dietary (Food On ly, and Food and Drinking Water) Exposure and Risk for Bensulide at the 99.9 th 

### Percentile of Exposure.

Population Subgroup Food Only Food and Water (NC Cotton) Food and Water (CA Avocado) Dietary Exposure (mg/kg/day) % aPAD Dietary Exposure (mg/kg/day) % aPAD Dietary Exposure (mg/kg/day) % aPAD

General U.S. Population 0.003459 31 7.200738 >10000 0.259261 2400 All Infants (<1 year old)* 0.003299 30 15.584203 >10000 0.617566 5600 Children 1-2 years old 0.004436 40 10.366006 >10000 0.381599 3500 Children 3-5 years old* 0.005016 46 6.774460 >10000 0.274069 2500 Children 6-12 years old 0.003835 35 6.321278 >10000 0.214996 2300 Youth 13-19 years old 0.002713 25 4.816789 >10000 0.180075 2000 Adults 20-49 years old 0.002241 20 5.199845 >10000 0.205208 1600 Adults 50-99 years old 0.002124 1.9 4.856943 4400 0.187992 170 Females 13-49 years old 0.002685 24 5.059084 >10000 0.202361 1800

* The subpopulation (with exception of Adults 50-99 years old) with the highest risk estimate is bolded.



### The acute dietary exposure estimates from food alone are below HED’s LOC at the 99.9 th 

### percentile of exposure for the general populat ion and all population subgroups. The highest exposed population subgroup was children 3-5 years old with an exposure of 0.005016 mg/kg/day occupying 46% of the aPAD. Exposur es are above the LOC for drinking water only, refer to Attachment 2. For food and drinking wa ter, using the drinking water scenario that provided the highest EDWC (NC Cotton), the dietary exposure es timates were >10,000 of the aPAD at the 95 th 

### , 99 th 

### and 99.9 th 

### percentile of exposure for mo st population subgroups with AllBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 12 of 47 

### Infants (< 1 year old) having the highest expos ure (Table 7 and Attachment 2). In addition, using the drinking water scenario (California Avocado) that provided the lowest EDWC, the dietary exposure estimates were >1600% of the aPAD at the 99.9 th 

### percentile of exposure for the general population and most population subgroups. Although fo r Adults 50-99 years old the FQPA SF is 1x, exposures were above the LOC for food and drinking water (NC Cotton and CA Avocado) as well. In summary, acute aggreg ate (food and drinking wate r) dietary exposure estimates are above HED’s level of concern.

Results of Steady State Dietary (Food Only, and Food and Drinking Water) Exposure and Risk Analysis

The results of the steady state dietary exposur e and risk analysis for food only at the 95 th 

### , 99 th



### , and 99.9 th 

### percentiles of exposure are reporte d in Table 8 and those at the 99.9 th 

### percentile of exposure for food only and food and dri nking water are reported in Table 9.

Table 8. Results of Steady State Dietary (Food Only) Exposure and Risk Analysis.

Population Subgroup ssPAD (mg/kg/day) 95 th Percentile 99 th Percentile 99.9 th Percentile Exposure (mg/kg/day) % ssPAD Exposure (mg/kg/day) % ssPAD Exposure (mg/kg/day) % ssPAD General U.S. Population

0.006 for All Except Adults 50-99

years old which used 0.06 0.000696 12 0.001360 23 0.003454 58 All Infants (<1 year old) 0.000875 15 0.002355 39 0.003322 55 Children 1-2 years old 0.001593 27 0.002774 46 0.004436 74 Children 3-5 years old * 0.001541 26 0.003277 55 0.004779 80 Children 6-12 years old 0.000990 17 0.001544 26 0.003836 64 Youth 13-19 years old 0.000571 9.5 0.001001 17 0.002710 45 Adults 20-49 years old 0.000586 9.8 0.001041 17 0.002240 37 Adults 50-99 years old 0.000545 <1 0.001093 1.8 0.002121 3.6 Females 13-49 years old 0.000589 10 0.001031 17 0.002687 45 * The subpopulation (with exception of Adults 50-99 years old) with the highest risk estimate is bolded.



### Table 9. Summary of Steady State Dietary (Food Only, and Food and Drinking Water) Exposure and Risk for Bensulide at the 99.9 th 

### Percentile of Exposure.

Population Subgroup Food Only Food and Water (NC Cotton) Food and Water (CA Avocado) Dietary Exposure (mg/kg/day) % ssPAD Dietary Exposure (mg/kg/day) % ssPAD Dietary Exposure (mg/kg/day) % ssPAD

General U.S. Population 0.003454 58 7.197920 >10000 0.256468 4300 All Infants (<1 year old) 0.003322 55 15.581721 >10000 0.603403 >10000 Children 1-2 years old 0.004436 74 10.393019 >10000 0.378531 6300 Children 3-5 years old* 0.004779 80 6.795017 >10000 0.267948 4500 Children 6-12 years old 0.003836 64 6.315285 >10000 0.212895 3500 Youth 13-19 years old 0.002710 45 4.781498 >10000 0.176266 2900 Adults 20-49 years old 0.002240 37 5.194808 >10000 0.200449 3300 Adults 50-99 years old 0.002121 3.6 4.851935 8100 0.182459 300 Females 13-49 years old 0.002687 45 5.053817 >10000 0.196688 3300

* The subpopulation (with exception of Adults 50-99 years old) with the highest risk estimate is bolded.Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

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### The steady state dietary exposur e estimates from food alone are below HED’s LOC at the 99.9 th 

### percentile of exposure for the general populat ion and all population subgroups. The highest exposed population subgroup was children 3-5 years old with an exposure of 0.004779 mg/kg/day occupying 80% of the ssPAD. Exposures are above the LOC for drinking water only; refer to Attachment 2. For food and drinking wate r, using the scenario th at provided the highest EDWC, dietary exposure estimates were >10,000 of the ssPAD at the 95 th 

### , 99 th 

### and 99.9 th 

### percentile of exposure for popula tion subgroups with All Infants (< 1 year old) having the highest exposure (Table 9 and Attachment 2). In addition, using the drinking water scenario (California Avocado) th at provided the lowest EDWC, th e dietary exposure estimates were >2900% of the ssPAD at the 99.9 th 

### percentile of exposure for the general population and all population subgroups. Although for Adults 50-99 y ears old the FQPA SF is 1x, exposures were above the LOC for food and drinking water (NC Cotton and CA Avocado) as well. In summary, steady state aggregate (food and drinking water) dietary exposu re estimates are above HED’s level of concern.

VIII. Characterization of Inputs/Outputs

HED has conducted a refined acute and steady stat e dietary exposure and risk assessments for bensulide and its oxon. The assumptions with respect to food made in this acute and steady state dietary assessment include the la test PDP monitoring data for be nsulide and the oxon, anticipated residues, default DEEM processing factors, and percent crop treated when available. The FQPA 10x Safety Factor was retained for all exposure scenarios; and in lieu of the absence of bensulide’s oxon CCA data, an oxon TAF of 50x was used. Drinking water was a main driver in the acute and steady state food a nd drinking water assessments for the general U.S. population and all population subgroups. These factors resulted in the acute and stea dy state aggregate (food and drinking water) dietary exposure estimates to be above HED’s level of concern.

Overall, the dietary assessments could be refined if a CCA study were available to establish a TAF for the oxon. Additional fate data would be needed to further refine the drinking water assessment. In general, the main uncertainti es with the bensulide oxon exposure estimate are lack of aerobic soil metabolism (testing more than one soil) and aerobi c aquatic studies for bensulide and bensulide oxon, and lack of a bensulide oxon hydrol ysis study; refer to EFED memo for details. Although food is not the main contributor to the di etary risk, the critical exposure contribution analysis (Att achment 3) shows that tomato is the highest contributor to the food risk estimate; therefore, the dietary a ssessment for food only could be refined if %CT information or cooking factors were available for tomato.

IX. Conclusions

These partially refined analyses demonstrate that the registered uses for bensulide result in risk of concern for the general U.S. population a nd all population subgroups. Risks are below the level of concern for food only. HED is confident that the assessment does not underestimate risk to the general U.S. populati on or any population subgroup.

X. List of AttachmentsBensulide Dietary Exposure and Risk Assessment DP Number: D428878

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### Attachment 1. Data and Residue Estimates Used in the Dietary Exposure Analyses Attachment 2. Input and Result Files Attachment 3. Critical Exposure Cont ribution Analysis for Food Only Attachment 4. Screening Level Estimates for Bensulide Attachment 5. EDWC at the LOC Consider ing Exposure through Drinking Water OnlyBensulide Dietary Exposure and Risk Assessment DP Number: D428878

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### Attachment 1. Data and Residue Estimate s Used in the Dietary Exposure Analyses.

Residue Data

Table A.1.1 summarizes residue data for commodities that do not have PDP data available for both parent bensulide and its oxon. The purpose is to provide info rmation to address the dietary exposure and risk assessment. In addition, PDP data for lettuce (in which bensulide and its oxon were measured) were included.

Table A.1.1. Summary of Residue Levels for Bensulide and its Oxon Matrix (Reference) Use Pattern / PDP Sample ID Bensulide Bensulide Oxon Factor (Oxon/Parent) Tomato Metabolism (D179576, 04/21/1993) 8.6 lbs ai/A pre-plant 112-153 day PHI ND (86% TRR iden/char) ND (86% TRR iden/char) NA

Lettuce Metabolism (D1855889, 03/29/1993) 8.6 lbs ai/A soil preplant 67 day PHI ND (86% TRR extracted) 2% TRR (86% TRR extracted) NA

Carrot Metabolism (D177460, 06/02/1992) 8.6 lbs ai/A soil preplant 126 day PHI 30% TRR (94% TRR extracted) 2.8% TRR (94% TRR extracted) 0.09x

Squash Field Data (D218256, 01/24/1996) 9 lbs ai/A pre-plant ND 1 ND 1 NA

Cucumber Field Data (D218256, 01/24/1996) 9 lbs ai/A pre-plant ND 1 ND 1 NA

Bulb Onion (D206633, 11/29/1994) 9 lbs a.i./A pre-plant or

pre-emergence Harvest at Maturity ND 1 ND 1 NA

Bell Peppers (D238521, 10/07/1997) 5-9 lbs ai/A pre-plant or

pre-emergence 109-129 day PHIs ND 1 ND 1 NA

Lettuce PDP Results (years 2010-2011) 2010-6721 0.005 0.01 2.0 2010-6845 0.004 0.005 1.3 2010-7044 0.014 0.12 8.6 2010-7052 0.005 0.008 1.6 2010-7265 0.014 0.023 1.6 2011-6295 0.012 0.003 0.3

1 The LOQ is reported to be 0.05 ppm.



### Carrot

The carrot metabolism study shows that the oxon was detected at lower amounts than parent bensulide. PDP monitoring data (2012 to 2013) was generated fo r about 712 samples of carrots and 792 samples of carrot baby food. Be nsulide (limit of detection (LOD) ≤ 0.02 ppm) or its oxon (LOD ≤ 0.002 ppm) were not detected above the L OD in samples of carrot. Similarly, no detects were reported for samples of baby f ood (LOD of 0.004 ppm for bensulide and 0.002 ppm for oxon). Therefore, a residue estimat e of 0.12 ppm (0.002 ppm * 50 + 0.02 ppm) is recommended for carrot and 0.104 ppm (0.002 pp m * 50 + 0.004 ppm) is obtained for carrotBensulide Dietary Exposure and Risk Assessment DP Number: D428878

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### baby food. Following ChemSAC decision (09/19 /1998) on the use of the 1⁄2 LOD, the recommended anticipated residues are 0.060 ppm for carrot and 0.052 fo r carrot baby food.

Onion

Crop field trial data for bulb onion do not show presence of bensulide or its oxon above the LOD of 0.05 ppm. In 744 samples of onion measured between 2010 and 2011, there were no detects of bensulide above the LOD ( ≤ 0.005 ppm). This data suggests th at neither parent bensulide nor its oxon are likely to be present above the LOD of 0.005 ppm in bulb onion. Therefore, a residue estimate of 0.255 ppm (0.005 ppm * 50 + 0.005 ppm) is obtained for bulb onion. Following ChemSAC decision on the use of the 1⁄2 LOD, the recommended anticipated residue is 0.1275

ppm.

Garlic and Shallot

The tolerance for bulb onion applies to garlic and shallot. Both commodities have uses in the label of Prefar 4E. Therefore, the PDP monitori ng data for bulb onion will be used for garlic and shallot assuming 100% of crop treated.

Leafy Vegetables, Except Brassica, Crop Group 4

Lettuce: The metabolism study with lettuce showed detection of the oxon but not of the parent bensulide which suggest that the oxon may pre dominate. PDP data for lettuce (years 2010 and 2011) shows that bensulide (LOD ≤ 0.004 ppm) was detected in 6 of 1487 samples whereas bensulide oxon (LOD ≤ 0.002 ppm) was detected in 49 of those 1487 samples. The samples in which both were detected were included in the ta ble above in order to estimate the ratio of the concentration of the oxon with respect to parent bensulide. These factors range from 0.3 to 8.6. This data suggest a factor of 9x for oxon residues w ith respect to bensulide. Lettuce PDP data is divided between head lettuce and leaf lettuce. The number of detects for leaf lettuce is higher than that for head lettuce; however, the maximum LOD for both commodities is similar. A residue estimate of 0.104 ppm (0.002 ppm * 50 + 0.004 ppm) is obtained for lettuce. Following ChemSAC decision on the use of the 1⁄2 LOD, the recommended residue is 0.052 ppm.

Celery: PDP results for bensulide are available bu t not for its oxon. In 346 samples measured in 2013, there were no detects of bensulide above the LOD ( ≤ 0.003 ppm). Celery is a member of the leafy vegetables (crop gr oup 4) along with lettuce and sp inach. The metabolism and PDP data for lettuce suggest a factor of 9x for oxon residues with respect to bensulide. This factor can be applied to the bensulide oxon. As a conserva tive measure this factor will be applied to all the samples of celery. In addition, a 50x relative potency factor recommended for conversion of bensulide to its oxon is applied. This results in a residue estimate of 1.353 ppm (0.003 ppm * 9 * 50 + 0.003 ppm) for celery. Following ChemSAC decision on the use of the 1⁄2 LOD, the recommended anticipate d residue is 0.6765 ppm.

Spinach (Frozen and Canned): PDP results for bensulide are available but not for its oxon. In 379 samples of canned spinach measured be tween 2010 and 2011, there were no detects of bensulide above the LOD ( ≤ 0.003 ppm). In 389 samples of frozen spinach measured betweenBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 17 of 47 

### 2010 and 2011, there were 2 detects of bensulide above the LOD ( ≤ 0.003 ppm). Spinach is a member of the leafy vegetables (crop group 4) al ong with lettuce. The metabolism and PDP data for lettuce suggest a factor of 9x fo r oxon residues with respect to be nsulide. This factor can be applied to the bensulide oxon. As a conservative measure this factor will be applied to all the samples of spinach. This results in a resi due estimate of 1.353 pp m (0.003 ppm * 9 * 50 + 0.003 ppm) for spinach. Following ChemSAC decisi on on the use of the 1⁄2 LOD, the recommended residue is 0.6765 ppm.

Spinach Fresh: No PDP monitoring data for fresh spinach is available. Leaf lettuce PDP data were translated to fresh spinach.

Other Commodities in Crop Group 4 except Radicchio: The SOP for translation of pesticide monitoring data (HED SOP 99.3; 03/26/1999) su ggests use of spinach to cover other commodities under this crop group. Ho wever, since the data for leaf lettuce is more robust and showed the highest number of detects (i.e., 48 detect s in 782 samples for leaf lettuce, 1 detect in 669 samples for head lettuce, 0 detects in 379 sa mples of canned spinach, and 2 detects in 389 samples of frozen spinach), this data will be translated to ot her commodities under crop group 4. This determination was made after consu ltation with Bernie Schneider on 09/22/2015.

Brassica Leafy Vegetables, Crop Group 5

No PDP data are available for commod ities under crop group 5. The following recommendations are based on the SOP for tr anslation of monitoring data (SOP 99.3; 03/26/1999) and additional disc ussions on crop translations.

Cabbage, brussel sprouts, radicchio and broccoli: PDP data from head lettuce was used for cabbage, Brussel sprouts and radi cchio since all have a head morphology. The data for head lettuce was translated to brocco li as well. Head lettuce and cabbage have a head morphology; cabbage is a member of crop subgr oup 5A along with broccoli. This was considered an adequate approach in the absence of data for broccoli (after consultation w ith Bernie Schneider on 09/25/2015). This translation was made as a refinement of the dietary assessment.

Mustard greens and commodities under crop subgroup 5B: PDP data from spinach could be used; however, it is only available for ca nned and frozen commodities and the oxon was not measured. Leaf lettuce will be used based on its robust data set, high frequency of detects, and leaf morphology. Indeed, leaf lettuce and spin ach are members of crop subgroup 4A; therefore, the use of leaf lettuce data instead of spinach can be considered appropr iate. After consultation with Bernie Schneider (09/22/2015), this was determined to be an acceptable translation.

Cauliflower, and other commodities under crop subgroup 5A: PDP data is not available for these or similar commodities. Based on this, crop field trial data will be used. The concentrations are 0.10 ppm for bensulide (twice the LOQ due to storage stability issues, see residue chemistry chapter), and 0.05 ppm for be nsulide oxon (LOQ level). The residue value estimated is 2.6 ppm (0.05 ppm * 50 + 0.10 ppm). Following ChemSAC decision on the use of the 1⁄2 LOD, the recommended anticipated residue is 1.3 ppm.Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

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### Fruiting Vegetables, Crop Group 8

Tomato: PDP data for cherry tomato was generated in 2011 and 2012; of 1482 samples measured, parent bensulide was de tected in only two samples (LOD ≤ 0.003 ppm) while the bensulide oxon was not detected (LOD ≤ 0.004 ppm). Therefore, for tomato, an RDF file can be constructed using a residue estimate of 0.203 ppm (0.004 ppm * 50 + 0.003 ppm), including samples with detects. Following ChemSA C decision on the use of the 1⁄2 LOD, the recommended residue is 0.1015 ppm.

Peppers: Crop field trial data for bell peppers do not show presence of bensulide or its oxon above the LOD of 0.05 ppm. The metabolism study with tomato, another representative commodity of the fruiting vegetable crop group 8- 10, does not show presence of bensulide or its oxon above the LOD of 0.001 ppm. Moreover, PDP da ta for cherry tomato show that parent bensulide was detected in only two samples while the bensulide oxon was not detected. All this data suggest that low levels of bensulide or its oxon may be present in peppers. PDP data was obtained for hot peppers (non- bell pepper) between 2010 and 2011; 367 samples do not show residues of bensulide above the LOD of 0.002 ppm. The oxon analog was not measured. Because the metabolism of bensulide in peppers is likely to be similar to tomato and the crop field trial data and PDP data in both matrices suggest low levels of bensulide and its oxon, it is recommended that the oxon analog is assumed to have similar levels to bensulide. Therefore, a residue estimate of 0.102 pp m (0.002 ppm * 50 + 0.002 ppm) is recommended for peppers. Following ChemSAC decision on the use of the 1⁄2 LOD, the recommended residue is 0.051 ppm.

Other commodities under crop group 8: Based on the SOP for tran slation of monitoring data, the data for tomato or peppers can be transl ated to other members of crop group 8. As a conservative measure, the data from tomato will be translated to all commodities of crop group 8 other than peppers.

Cucurbit Vegetables, Crop Group 9

Summer Squash: Crop field trial data for squash do not s how presence of bensulide or its oxon. Moreover, crop field trial for cucumber, anot her representative commodity for cucurbit vegetables (crop group 9), do not shows presence of bensulide or its oxon. PDP data for summer squash measured between 2012 and 2013 showed no detects of bensulide (895 samples) or its oxon (438 samples) above the LOD ( ≤ 0.005 ppm). Therefore, a residue of 0.255 ppm (0.005 ppm * 50 + 0.005 ppm) is estimated for squash. Following ChemSAC decision on the use of the 1⁄2 LOD, the recommended anti cipated residue is 0.1275 ppm.

Winter Squash: Crop field trial data for squash do not s hows presence of bensulide or its oxon. Moreover, crop field trial data for cucumber, a nother representative commodity for cucurbit vegetables crop group 9, do not show presence of bensulide or its oxon. PDP monitoring data for winter squash is available for bensulide but not for its oxon. In 1115 samples of winter squash measured between 2011 and 2013, there were no detects of bensulide above the LOD ( ≤ 0.002 ppm). The absence of detects in the field trial data for squash and cucumber and the PDP data for summer squash suggests that neither pa rent bensulide nor its oxon are likely to be present above the LOD of 0.005 ppm in squash. Therefore, a residue of 0.102 ppm (0.002 ppm *Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 19 of 47 

### 50 + 0.002 ppm) is estimated for winter squash. Following ChemSAC decision on the use of the 1⁄2 LOD, the recommended anti cipated residue is 0.051 ppm.

Muskmelon, watermelon, pumpkin, chayote and other commodities under crop subgroup 9A: Based on the SOP for translation of monitoring data, data from winter squash can be translated to muskmelon, watermelon and commodities under cr op subgroup 9A. Because the data set for summer squash is more robust (the oxon is measur ed) and has more conservative LODs than that of winter squash, this data set will be translated to these commodities. In addition, this data will be translated to Chayote fruit (after consultati on with Bernie Schneider on 09/25/2015). Indeed, the current crop group for cucurbits have summer squash as the representative commodity of crop group 9 and subgroup 9B (which includes chayote).

Cucumber and other commodities under crop subgroup 9B: Based on the absence of PDP data, crop field trial data will be used for these co mmodities. The concentrations are 0.10 ppm for bensulide (twice the LOQ due to storage stability issues, see residue chemistry chapter), and 0.05 ppm for bensulide oxon (LOQ level). The reco mmended residue value is 2.6 ppm (0.05 ppm * 50 + 0.10 ppm). Following ChemSAC decision on the use of the 1⁄2 LOD, the recommended anticipated residue is 1.3 ppm.

Note on Translation of PDP Monitoring Data

Application rates (5-6 quartz/A) and timing of application (preplan t/preemergence) of Prefar 4E (bensulide’s end-use product) are similar for a ll crops under cucurbit, bra ssica, fruiting and leafy vegetables crop groups. Theref ore, translation of PDP data following SOP 99.3 and other considerations is considered acc eptable with respect to the us e pattern of the pesticide.Bensulide Dietary Exposure and Risk Assessment DP Number: D428878Page 20 of 47Table A.1.2. Data and Residue Estimates Usedin the Bensulide Dietary Exposure Analyses.RACCropSubgroupFoodFormsBlendingClassifi-cation1DataSourceNo. ofSamplesNo. ofDetectableResiduesLOD (ppm)1⁄2 LOD(ppm)2Max%CTProcessingFactorsAnticipatedResidue EstimatesBensOxon4Acute (Tol., AR,RDF)Carrot 1AB All NB/PB Carrot PDP 2013 712 0 0.02 0.002 0.060 100 RDF 1Carrot-babyfood 1AB AllNB/PBCarrot babyfoodPDP 2012792 0 0.004 0.002 0.052 100 RDF 2Carrot, juice 1AB AllNB/PB Carrot PDP 2013712 0 0.02 0.002 0.060 100 RDF 1Onion, bulb 3A AllNB/PBOnion PDP 2011and 2012744 0 0.0050.0050.13 20 RDF 3Onion, bulbbabyfood3A AllNB/PBOnion PDP 2011and 2012744 0 0.0050.0050.13 20 RDF 3Onion, bulb, dried 3A AllBOnion PDP 2011and 2012744 0 0.0050.0050.13 20 9.0Point Estimate0.026 ppmOnion, bulb,dried-babyfood3A AllBOnion PDP 2011and 2012744 0 0.0050.0050.13 20 9.0Point Estimate0.026 ppmGarlic, bulb 3A All NB/PBOnion PDP 2011and 2012744 0 0.0050.0050.13 100 RDF 25Garlic, bulb, dried 3A All BOnion PDP 2011and 2012744 0 0.0050.0050.13 100Point Estimate0.13 ppmGarlic, bulbbabyfood3A All NB/PBOnion PDP 2011and 2012744 0 0.0050.0050.13 100 RDF 25Shallot, bulb 3A All NBOnion PDP 2011and 2012744 0 0.0050.0050.13 100 RDF 25Leafy Vegetable, except brassica, crop group 4Amaranth, leafy 4A AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052 100 RDF 4Arugula 4A AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Chrysanthemum,garland4A AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Cress, garden 4A AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Cress, upland 4A AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Dandelion, leaves 4A AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Bensulide Dietary Exposure and Risk Assessment DP Number: D428878Page 21 of 47Endive 4A AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Lettuce, head 4A AllNB/PBHead Lettuce PDP2010 and 2011669 1 0.004 0.002 0.05240 RDF 5Lettuce, leaf 4A AllNB/PBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.05240 RDF 6Parsley, leaves 4A AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Radicchio 4A AllNBHead Lettuce PDP2010 and 2011669 1 0.004 0.002 0.052100 RDF 7Spinach 4A Fresh PBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.05210 RDF 8Canned PBSpinach CannedPDP 2010 and 2011379 0 0.0030.0030.68 10 RDF 9Frozen PBSpinach FrozenPDP 2010 and 2011389 2 0.0030.0030.68 10 RDF 10Spinach-babyfood 4A Canned PBSpinach CannedPDP 2010 and 2011379 0 0.0030.0030.6810 RDF 9Cardoon 4B AllNBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Celery 4B AllNB/PB Celery PDP 2013346 0 0.0030.0030.685 RDF 11Celery-babyfood 4B AllNB/PB Celery PDP 2013346 0 0.0030.0030.685 RDF 11Celery, juice 4B AllPB Celery PDP 2013346 0 0.0030.0030.685 RDF 11Celtuce 4B AllNBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Fennel, Florence 4B AllNBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Rhubarb 4B AllNB/PBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Swiss chard 4B All NBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Brassica Leafy Vegetables, Crop Group 5Broccoli 5A AllNB/PBHead Lettuce PDP2010 and 2011669 1 0.004 0.002 0.05225 RDF 12Broccolibabyfood5A AllNB/PBHead Lettuce PDP2010 and 2011669 1 0.004 0.002 0.05225 RDF 12Broccoli, Chinese 5A AllNB Tolerance0.10 0.05 1.3 100Point Estimate1.3 ppmBensulide Dietary Exposure and Risk Assessment DP Number: D428878Page 22 of 47Brussels sprouts 5A AllNB/PBHead Lettuce PDP2010 and 2011669 1 0.004 0.002 0.0525 RDF 13Cabbage 5A AllNB/PBHead Lettuce PDP2010 and 2011669 1 0.004 0.002 0.05220 RDF 14Cabbage, Chinese,napa5A AllNB/PB Tolerance0.10 0.05 1.3 100Point Estimate1.3 ppmCabbage, Chinese,mustard5A AllNB/PB Tolerance0.10 0.05 1.3 100Point Estimate1.3 ppmCauliflower 5A AllNB/PB Tolerance0.10 0.05 1.3 20 RDF 15Kohlrabi 5A AllNB Tolerance0.10 0.05 1.3 100Point Estimate1.3 ppmBroccoli raab 5B AllNBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Cabbage, Chinese,bok choy5B AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Collards 5B AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Kale 5B AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Mustard greens 5B AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Rape greens 5B AllPBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Turnip, greens 5B AllNB/PBLeaf Lettuce PDP2010 and 2011782 48 0.004 0.002 0.052100 RDF 4Fruiting Vegetables, Crop Group 8Tomatillo 8A AllNB/PBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 RDF 16Tomato 8A AllNB/PBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 RDF 16Tomato-babyfood 8A AllNB/PBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 RDF 16Tomato, paste 8A AllBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 5.4Point Estimate0.10 ppmTomato, pastebabyfood8A AllBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 5.4Point Estimate0.10 ppmTomato, puree 8A AllBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 3.3Point Estimate0.10 ppmBensulide Dietary Exposure and Risk Assessment DP Number: D428878Page 23 of 47Tomato, pureebabyfood8A AllBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 3.3Point Estimate0.10 ppmTomato, dried 8A AllBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 14.3Point Estimate0.10 ppmTomato, driedbabyfood8A AllBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 14.3Point Estimate0.10 ppmTomato, juice 8A AllNB/PBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 1.5 RDF 16Tomato, Tree 8A AllNBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 RDF 16Eggplant 8BC AllNB/PBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 RDF 16Okra 8BC AllNB/PBCherry Tomato PDP2011 and 20121482 2 0.003 0.004 0.10 100 RDF 16Pepper, bell 8B AllNB/PBHot Peppers PDP2010 and 2011367 0 0.002 0.002 0.051 10 RDF 17Pepper, bellbabyfood8B AllNB/PBHot Peppers PDP2010 and 2011367 0 0.002 0.002 0.051 10 RDF 17Pepper, bell, dried 8B AllBHot Peppers PDP2010 and 2011367 0 0.002 0.002 0.051 10Point Estimate0.0051 ppmPepper, bell,dried-babyfood8B AllBHot Peppers PDP2010 and 2011367 0 0.002 0.002 0.051 10Point Estimate0.0051 ppmPepper, nonbell 8BC AllNB/PBHot Peppers PDP2010 and 2011367 0 0.002 0.002 0.051 10 RDF 17Pepper, nonbellbabyfood8BC AllNB/PBHot Peppers PDP2010 and 2011367 0 0.002 0.002 0.051 10 RDF 17Pepper, nonbell,dried8BC AllBHot Peppers PDP2010 and 2011367 0 0.002 0.002 0.051 10Point Estimate0.051 ppmCucurbit Vegetables, Crop Group 9Cantaloupe 9A AllNB/PBSummer SquashPDP 2012 and 2013895/43830 0.005 0.005 0.13 40 RDF 18Honeydew melon 9A AllNB/PBSummer SquashPDP 2012 and 2013895/43830 0.005 0.005 0.1330 RDF 19Watermelon 9A AllNBSummer SquashPDP 2012 and 2013895/43830 0.005 0.005 0.1310 RDF 20Watermelon, juice 9A AllPBSummer SquashPDP 2012 and 2013895/43830 0.005 0.005 0.1310 RDF 20Balsam pear 9B AllNB Tolerance0.10 0.05 1.3 100Point Estimate1.3 ppmBensulide Dietary Exposure and Risk Assessment DP Number: D428878Page 24 of 47Chayote, fruit 9B AllNBSummer SquashPDP 2012 and 2013895/43830 0.005 0.005 0.13100 RDF 24Chinese waxgourd 9B AllNB Tolerance0.10 0.05 1.3 100Point Estimate1.3 ppmCucumber 9B AllNB/PB Tolerance 0.10 0.05 1.3 5 RDF 21Pumpkin 9B AllNB/PBSummer SquashPDP 2012 and 2013895/43830 0.005 0.005 0.1310 RDF 20Pumpkin, seed 9B AllBSummer SquashPDP 2012 and 2013895/43830 0.005 0.005 0.1310Point Estimate0.13 ppmSquash, summer 9B AllNB/PBSummer SquashPDP 2012 and 2013895/43830 0.005 0.005 0.13 15 RDF 22Squash, summerbabyfood9B AllNB/PBSummer SquashPDP 2012 and 2013895/43830 0.005 0.005 0.13 15 RDF 23Squash, winter 9B AllNB/PBWinter Squash PDP2012 and 20131115 0 0.0020.0020.051 15 RDF 23Squash, winterbabyfood9B AllNB/PBWinter Squash PDP2012 and 20131115 0 0.0020.0020.051 15 RDF 231Classification: blended (B), partially blended (PB), not blended (NB).2The 1⁄2 LOD is calculated as(LOD of bensulide + 50 x LOD of Oxon) / 2for all commodities except spinach where it was calculated as(LOD of bensulide + 9 x 50 x LOD of Oxon) / 2.3Parent bensulide was analyzed in 895 samples;the oxon was analyzed in 438 of those samples.4LOD values in italics for the oxon were assumedto be at a similar level of parent bensulide.Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 25 of 47 Table A.1.3. Summary of PDP Data for Bensulide and its Oxon

2013 2012 2011 2010
Commodity # of Samples # of Detects Max LOD # of Samples # of Detects Max LOD # of Samples # of Detects Max LOD # of Samples # of Detects Max LOD BENSULIDE

Carrots 712 0 0.02

CarrotsBaby Food 792 0 0.004

Celery 346 0 0.003

Summer Squash 709 0 0.005 186 0 0.005

Winter Squash 187 0 0.002 742 0 0.002 186 0 0.002

Cherry Tomatoes 744 0 0.003 738 2 0.003

Hot Peppers 274 0 0.002 93 0 0.002

Onions 558 0 0.005 186 0 0.005

Lettuce 744 1 0.004 743 5 0.004

SpinachCanned 198 0 0.003 181 0 0.003

SpinachFrozen 198 0 0.003 191 2 0.003

BENSULIDE OXON

Carrots 712 0 0.002

CarrotsBaby Food 792 0 0.002

Celery

Summer Squash 346 0 0.005 92 0 0.005

Winter Squash Cherry Tomatoes 744 0 0.004 738 0 0.004

Hot Peppers Onions

Lettuce 744 9 0.002 743 40 0.002

SpinachCannedSpinachFrozenBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 26 of 47 Table A.1.4. RDF Files and Point Estimate Calculations RDF 1: Carrot_1.rdf PDP Data: CRFR (2013), Total Samples=712, Total Detects=0, Total LODs=712, Total Zeros=0 MaxPCT=1.000, Avg HLOD (NonDetects)=0.060 TOTALZ=0 TOTALLOD=712 LODRES=0.060 RDF 2: Carrot_BF_2.rdf PDP Data: ICPU (2012), Total Samples=792, Total Detects=0, Total LODs=792, Total Zeros=0 MaxPCT=1.000, Avg HLOD (NonDetects)=0.0520 TOTALZ=0 TOTALLOD=792 LODRES=0.0520 RDF 3: Onion_Bulb_3.rdf PDP Data: ONFR (2011,2012), Total Samples=744, Total Detects=0, Total LODs=149, Total Zeros=595, MaxPCT=0.200, Avg HLOD (NonDetects)=0.13 TOTALZ=595 TOTALLOD=149 LODRES=0.13 Point Estimate: Onion, bulb, dried Total Samples=744, Total Detects=0, Total LODs=149, Total Zeros=595, MaxPCT=0.200, Avg HLOD (NonDetects)=0.13

PE=[149 samples * 0.13 ppm + 595 samples * 0 ppm] /744 = 0.026 ppm RDF 4: Lettuce_Fresh_Leaf_ 100CT_4.rdf PDP Data: LTLF (2010,2011), Total Samples=782, Total Detects=48, Total LODs=734, Total Zeros=0, MaxPCT=1.000, Avg Residue (Detects)=0.432042, Avg Residue = 0.075327, Avg HLOD (NonDetects)=0.0520 TOTALZ=0 TOTALLOD=734 LODRES=0.0520 RDF 5: Lettuce_Fresh_Head_5.rdf PDP Data: LTHD (2010,2011), Total Samples=669, Total Detects=1, Total LODs=267, Total Zeros=401, MaxPCT=0.400, Avg Residue (Detects)=1.352000, Avg Residue (TOTALS)=0.0228, Avg HLOD (NonDetects)=0.0520 TOTALZ=401 TOTALLOD=267 LODRES=0.0520 1.352

6.014 1.602 1.402 1.164 0.802 0.752 0.505 0.502 0.452 0.405 0.402 0.352 0.302 0.302 0.302 0.254 0.252 0.252 0.252 0.202 0.202 0.202 0.202 0.202 0.202 0.202 0.202 0.202 0.202 0.202 0.162 0.152 0.152 0.152 0.152 0.152 0.152 0.152 0.102 0.102 0.102 0.102 0.102 0.102 0.102 0.102 0.102 0.102 RDF 6: Lettuce_Fresh_Leaf_6.rdf PDP Data: LTLF (2010,2011), Total Samples=782, Total Detects=48, Total LODs=265, Total Zeros=469, MaxPCT=0.400, Avg Residue (Detects)=0.432042, Avg Residue (TOTALS)=0.0441, Avg HLOD (NonDetects)=0.0520 TOTALZ=469 TOTALLOD=265 LODRES=0.0520 RDF 7: Lettuce_Fresh_Head_ 100CT_7.rdf PDP Data: LTHD (2010,2011), Total Samples=669, Total Detects=1, Total LODs=668, Total Zeros=0, MaxPCT=1.000, Avg Residue (Detects)=1.352000, Avg Residue=0.053943, Avg HLOD (NonDetects)=0.0520 TOTALZ=0 TOTALLOD=668 LODRES=0.0520 1.352 RDF 8: Lettuce_Fresh_Leaf_ 10CT_8.rdf PDP Data: LTLF (2010,2011), Total Samples=782, Total Detects=48, Total LODs=30, Total Zeros=704, MaxPCT=0.100, Avg Residue (Detects)=0.432042, Avg HLOD (NonDetects)=0.0520 TOTALZ=704 TOTALLOD=30 LODRES=0.0520 6.014 1.602 1.402 1.164 0.802 0.752 0.505 0.502 0.452 0.302 0.302 0.302 0.254 0.252 0.252 0.252 0.202 0.202 0.202 0.202 0.202 0.202 0.202 0.202 0.162 0.152 0.152 0.152 0.152 0.102 0.102 0.102 0.102 0.102 0.102 0.102 6.014 1.602 1.402 1.164 0.802 0.752 0.505 0.502 0.452 0.302 0.302 0.302 0.254 0.252 0.252 0.252 0.202 0.202 0.202 0.202 0.202 0.202 0.202 0.202 0.162 0.152 0.152 0.152 0.152 0.102 0.102 0.102 0.102 0.102 0.102 0.102Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 27 of 47 0.405 0.402 0.352 0.202 0.202 0.202 0.152 0.152 0.152 0.102 0.102 0.102 0.405 0.402 0.352 0.202 0.202 0.202 0.152 0.152 0.152 0.102 0.102 0.102 RDF 9: Spinach_Canned_9.rdf PDP Data: SCCA (2010,2011), Total Samples=379, Total Detects=0, Total LODs=38, Total Zeros=341, MaxPCT=0.100, Avg HLOD (NonDetects)=0.68 TOTALZ=341 TOTALLOD=38 LODRES=0.68 RDF 10: Spinach_Frozen_10.rdf PDP Data: SFFZ (2010,2011), Total Samples=389, Total Detects=2, Total LODs=37, Total Zeros=350, MaxPCT=0.100, Avg Residue (Detects)=1.75, Avg HLOD (NonDetects)=0.68 TOTALZ=350 TOTALLOD=37 LODRES=0.68 2.0 1.5 RDF 11: Celery_11.rdf PDP Data: CEFR (2013), Total Samples=346, Total Detects=0, Total LODs=17, Total Zeros=329 MaxPCT=0.050, Avg HLOD (NonDetects)=0.68 TOTALZ=329 TOTALLOD=17 LODRES=0.68

RDF 12: Lettuce_Fresh_Head_ 25CT_12.rdf PDP Data: LTHD (2010,2011), Total Samples=669, Total Detects=1, Total LODs=166, Total Zeros=502, MaxPCT=0.250, Avg Residue (Detects)=1.352000, Avg HLOD (NonDetects)=0.0520 TOTALZ=502 TOTALLOD=166 LODRES=0.0520 1.352 RDF 13: Lettuce_Fresh_Head_ 5CT_13.rdf PDP Data: LTHD (2010,2011), Total Samples=669, Total Detects=1, Total LODs=32, Total Zeros=636, MaxPCT=0.050, Avg Residue (Detects)=1.352000, Avg HLOD (NonDetects)=0.0520 TOTALZ=636 TOTALLOD=32 LODRES=0.0520 1.352 RDF 14: Lettuce_Fresh_Head_ 20CT_14.rdf PDP Data: LTHD (2010,2011), Total Samples=669, Total Detects=1, Total LODs=133, Total Zeros=535, MaxPCT=0.200, Avg Residue (Detects)=1.352000, Avg HLOD (NonDetects)=0.0520 TOTALZ=535 TOTALLOD=133 LODRES=0.0520 1.352 RDF 15: Cauliflower_Tolerance_ 20CT_15.rdf Tolerannce Level Residue MaxPCT=0.200, Avg HLOD (NonDetects)=1.3

TOTALZ=4 TOTALLOD=1 LODRES=1.3 RDF 16: Tomato_Cherry_16.rdf PDP Data: CTFR (2011,2012), Total Samples=1482, Total Detects=2, Total LODs=1480, Total Zeros=0, MaxPCT=1.000, Avg Residue (Detects)=0.105000, Avg HLOD (NonDetects)=0.1015 TOTALZ=0 TOTALLOD=1480 LODRES=0.1015 0.105 0.105 Point Estimate: Tomato Processed Commodities (Paste, Puree, Dried) Total Samples=1482, Total Detects=2, Total LODs=1480, Total Zeros=0, MaxPCT=1.000, Avg Residue (Detects)=0.105000, Avg HLOD (NonDetects)=0.1015

PE=[1480 samples * 0.10 ppm + 2 samples * 0.105 ppm] /1482 = 0.10

ppm

RDF 17: Pepper_Nonbell.rdf PDP Data: HPFR (2010,2011), Total Samples=367, Total Detects=0, Total LODs=37, Total Zeros=330, MaxPCT=0.100, Avg HLOD (NonDetects)=0.51 TOTALZ=330 TOTALLOD=37 LODRES=0.051 Point Estimate: Pepper, dried Total Samples=367, Total Detects=0, Total LODs=37, Total Zeros=330, MaxPCT=0.100, Avg HLOD (NonDetects)=0.51

PE=[37 samples * 0.051 ppm + 330 samples * 0 ppm] /367 = 0.0051

ppm RDF 18: Squash_Summer_40CT_ 18.rdf PDP Data: SSFR (2012,2013), Total Samples=895, Total Detects=0, Total LODs=358, Total Zeros=537, MaxPCT=0.400, Avg HLOD (NonDetects)=0.1275 TOTALZ=537 TOTALLOD=358 LODRES=0.1275 RDF 19: Squash_Summer_30CT_ 19.rdf PDP Data: SSFR (2012,2013), Total Samples=895, Total Detects=0, Total LODs=269, Total Zeros=626, MaxPCT=0.300, Avg HLOD (NonDetects)=0.1275 RDF 20: Squash_Summer_10CT_ 20.rdf PDP Data: SSFR (2012,2013), Total Samples=895, Total Detects=0, Total LODs=90, Total Zeros=805, MaxPCT=0.100, Avg HLOD (NonDetects)=0.1275 RDF 21: Cucumber_Tolerance_ 5CT_21.rdf Tolerannce Level Residue MaxPCT=0.050, Avg HLOD (NonDetects)=1.3

TOTALZ=95Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 28 of 47 TOTALZ=626 TOTALLOD=269 LODRES=0.1275 TOTALZ=805 TOTALLOD=90 LODRES=0.1275 TOTALLOD=5 LODRES=1.3

RDF 22: Squash_Summer.rdf PDP Data: SSFR (2012,2013), Total Samples=895, Total Detects=0, Total LODs=134, Total Zeros=761, MaxPCT=0.150, Avg HLOD (NonDetects)=0.1275 TOTALZ=761 TOTALLOD=134 LODRES=0.1275 RDF 23: Squash_Winter_Fresh.rdf PDP Data: WSFR (2011,2012,2013), Total Samples=1115, Total Detects=0, Total LODs=167, Total Zeros=948 MaxPCT=0.150, Avg HLOD (NonDetects)=0.051 TOTALZ=948 TOTALLOD=167 LODRES=0.051 RDF 24: Squash_Summer.rdf PDP Data: SSFR (2012,2013), Total Samples=895, Total Detects=0, Total LODs=895, Total Zeros=0, MaxPCT=1.000, Avg HLOD (NonDetects)=0.1275 TOTALZ=0 TOTALLOD=895 LODRES=0.1275

RDF 25: Onion_Bulb_25.rdf PDP Data: ONFR (2011,2012), Total Samples=744, Total Detects=0, Total LODs=744, Total Zeros=0, MaxPCT=1.000, Avg HLOD (NonDetects)=0.13 TOTALZ=0 TOTALLOD=744 LODRES=0.13Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 29 of 47 

### Attachment 2. Input and Result Files

A.2.1. Acute Dietary Assessment

Acute Input File

Filename: C:\Users\IEncarna\Dietary Assessments\Bensulide\BensulideDietary_FoodWater_Acute_Refined PDP CT.r08 Chemical: Bensulide Acute Food Water RfD(Chronic): 0 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .011 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 11-23-2015/17:17:21 Program ver. 3.16, 03-08-d

----------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis: Index Dist Parameter #1 Param #2 Param #3 Comment # Code

----- ---- ------------ -------- -------- ------- 1 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Carrot_1.rdf 2 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Carrot_BabyFood_2.rdf 3 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Onion_Bulb_3.rdf 4 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Leaf_100CT_4.rdf 5 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Head_5.rdf 6 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Leaf _6.rdf 7 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Head_100CT_7.rdf 8 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Leaf_10CT_8.rdf 9 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Spinach_Canned_9.rdf 10 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Spinach_Frozen_10.rdf 11 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Celery_11.rdf 12 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Head_25CT_12.rdf 13 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Head_5CT_13.rdf 14 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Head_20CT_14.rdf 15 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Cauliflower_Tolerance_20CT_15.rdf 16 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Tomato_Cherry_16.rdf 17 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Pepper_Nonbell_17.rdf 18 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Squash_Summer_40CT_18.rdf 19 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Squash_Summer_30CT_19.rdf 20 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Squash_Summer_10CT_20.rdf 21 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Cucumber_Tolerance_5CT_21.rdf 22 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Squash_Summer_22.rdf 23 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Squash_Winter_Fresh_23.rdfBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 30 of 47 24 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Squash_Summer_100CT_24.rdf 25 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Onion_Bulb_25.rdf 26 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Bensulide_Acute_NC Eastern Costal Plain.rdf

EPA Crop Commodity Name Def Res Adj.Factors RDLComment Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- ------- 0101078000 1AB Carrot 1.000000 1.000 1.000 1 Carrot Full comment: Carrot, 100%CT 0101078001 1AB Carrot-babyfood 1.000000 1.000 1.000 2 Carrot Full comment: Carrot BabyFood, 100%CT 0101079000 1AB Carrot, juice 1.000000 1.000 1.000 1 Carrot Full comment: Carrot, 100%CT 0301165000 3A Garlic, bulb 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 130-Uncooked; Dried; Cook Meth N/S 0.130000 1.000 1.000 Point Full comment: Point Est, Blend Onion, 100%CT 140-Uncooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 150-Uncooked; Cured etc; Cook Meth N/S 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 214-Cooked; Fresh or N/S; Fried/baked 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 215-Cooked; Fresh or N/S; Boiled/baked 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 220-Cooked; Frozen; Cook Meth N/S 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 222-Cooked; Frozen; Boiled 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 230-Cooked; Dried; Cook Meth N/S 0.130000 1.000 1.000 Point Full comment: Point Est, Blend Onion, 100%CT 232-Cooked; Dried; Boiled 0.130000 1.000 1.000 Point Full comment: Point Est, Blend Onion, 100%CT 233-Cooked; Dried; Fried 0.130000 1.000 1.000 Point Full comment: Point Est, Blend Onion, 100%CT 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 242-Cooked; Canned; Boiled 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 250-Cooked; Cured etc; Cook Meth N/SBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 31 of 47 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 252-Cooked; Cured etc; Boiled 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 0301165001 3A Garlic, bulb-babyfood 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 0301237000 3A Onion, bulb 1.000000 1.000 1.000 3 Onion, Full comment: Onion, 20%CT 0301237001 3A Onion, bulb-babyfood 1.000000 1.000 1.000 3 Onion, Full comment: Onion, 20%CT 0301238000 3A Onion, bulb, dried 0.026000 9.000 1.000 Point Full comment: Point Est, Blend Onion 0301238001 3A Onion, bulb, dried-babyfood 0.026000 9.000 1.000 Point Full comment: Point Est, Blend Onion 0301338000 3A Shallot, bulb 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100%CT 0401005000 4A Amaranth, leafy 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401018000 4A Arugula 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401104000 4A Chrysanthemum, garland 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401133000 4A Cress, garden 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401134000 4A Cress, upland 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401138000 4A Dandelion, leaves 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401150000 4A Endive 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401204000 4A Lettuce, head 1.000000 1.000 1.000 5 Head L Full comment: Head Lettuce, 40%CT 0401205000 4A Lettuce, leaf 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 40%CT 0401248000 4A Parsley, leaves 1.000000 1.000 1.000 6 Leaf L Full comment: Leaf Lettuce, 100%CT 0401313000 4A Radicchio 1.000000 1.000 1.000 7 Head L Full comment: Head Lettuce, 100%CT 0401355000 4A Spinach 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 212-Cooked; Fresh or N/S; Boiled
1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 215-Cooked; Fresh or N/S; Boiled/baked 1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 220-Cooked; Frozen; Cook Meth N/S 1.000000 1.000 1.000 10 Spinac Full comment: Spinach Frozen, 10%CT 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 10 Spinac Full comment: Spinach Frozen, 10%CT 222-Cooked; Frozen; Boiled 1.000000 1.000 1.000 10 Spinac Full comment: Spinach Frozen, 10%CT 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 240-Cooked; Canned; Cook Meth N/SBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 32 of 47 1.000000 1.000 1.000 9 Spinac Full comment: Spinach Canned, 10%CT 242-Cooked; Canned; Boiled 1.000000 1.000 1.000 9 Spinac Full comment: Spinach Canned, 10%CT 0401355001 4A Spinach-babyfood 1.000000 1.000 1.000 9 Spinac Full comment: Spinach Canned, 10%CT
0402076000 4B Cardoon 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0402085000 4B Celery 1.000000 1.000 1.000 11 Celery Full comment: Celery, 5%CT 0402085001 4B Celery-babyfood 1.000000 1.000 1.000 11 Celery Full comment: Celery, 5%CT 0402086000 4B Celery, juice 1.000000 1.000 1.000 11 Celery Full comment: Celery, 5%CT 0402087000 4B Celtuce 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0402152000 4B Fennel, Florence 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0402322000 4B Rhubarb 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0402367000 4B Swiss chard 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0501061000 5A Broccoli 1.000000 1.000 1.000 12 Head L Full comment: Head Lettuce, 25%CT 0501061001 5A Broccoli-babyfood 1.000000 1.000 1.000 12 Head L Full comment: Head Lettuce, 25%CT 0501062000 5A Broccoli, Chinese 1.300000 1.000 1.000 Tolera Full comment: Tolerance, 100%CT 0501064000 5A Brussels sprouts 1.000000 1.000 1.000 13 Head L Full comment: Head Lettuce, 5%CT 0501069000 5A Cabbage 1.000000 1.000 1.000 14 Head L Full comment: Head Lettuce, 20%CT 0501071000 5A Cabbage, Chinese, napa 1.300000 1.000 1.000 Tolera Full comment: Tolerance, 100%CT 0501072000 5A Cabbage, Chinese, mustard 1.300000 1.000 1.000 Tolera Full comment: Tolerance, 100%CT 0501083000 5A Cauliflower 1.000000 1.000 1.000 15 Tolera Full comment: Tolerance, 20%CT 0501196000 5A Kohlrabi 1.300000 1.000 1.000 Tolera Full comment: Tolerance, 100%CT 0502063000 5B Broccoli raab 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0502070000 5B Cabbage, Chinese, bok choy 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0502117000 5B Collards 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0502194000 5B Kale 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0502229000 5B Mustard greens 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0502318000 5B Rape greens 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0502389000 5B Turnip, greens 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0801374000 8A Tomatillo 1.000000 1.000 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0801375000 8A Tomato 1.000000 1.000 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0801375001 8A Tomato-babyfood 1.000000 1.000 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0801376000 8A Tomato, paste 0.100000 5.400 1.000 Point Full comment: Point Est, Blend, Tomato 0801376001 8A Tomato, paste-babyfood 0.100000 5.400 1.000 Point Full comment: Point Est, Blend, Tomato 0801377000 8A Tomato, puree 0.100000 3.300 1.000 Point Full comment: Point Est, Blend, Tomato 0801377001 8A Tomato, puree-babyfood 0.100000 3.300 1.000 PointBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 33 of 47 Full comment: Point Est, Blend, Tomato 0801378000 8A Tomato, dried 0.100000 14.300 1.000 Point Full comment: Point Est, Blend, Tomato 0801378001 8A Tomato, dried-babyfood 0.100000 14.300 1.000 Point Full comment: Point Est, Blend, Tomato 0801379000 8A Tomato, juice 0.100000 1.500 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0801380000 8A Tomato, Tree 1.000000 1.000 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0802148000 8BC Eggplant 1.000000 1.000 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0802234000 8BC Okra 1.000000 1.000 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0802270000 8B Pepper, bell 1.000000 1.000 1.000 17 Hot Pe Full comment: Hot Pepper, 10%CT 0802270001 8B Pepper, bell-babyfood 1.000000 1.000 1.000 17 Hot Pe Full comment: Hot Pepper, 10%CT 0802271000 8B Pepper, bell, dried 0.005100 1.000 1.000 Point Full comment: Point Est, Blend, Pepper 0802271001 8B Pepper, bell, dried-babyfood 0.005100 1.000 1.000 Point Full comment: Point Est, Blend, Pepper 0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 17 Hot Pe Full comment: Hot Pepper, 10%CT 0802272001 8BC Pepper, nonbell-babyfood 1.000000 1.000 1.000 17 Hot Pe Full comment: Hot Pepper, 10%CT 0802273000 8BC Pepper, nonbell, dried 0.005100 1.000 1.000 Point Full comment: Point Est, Blend, Pepper 0901075000 9A Cantaloupe 1.000000 1.000 1.000 18 Summer Full comment: Summer Squash, 40%CT 0901187000 9A Honeydew melon 1.000000 1.000 1.000 19 Summer Full comment: Summer Squash, 30%CT 0901399000 9A Watermelon 1.000000 1.000 1.000 20 Summer Full comment: Summer Squash, 10%CT 0901400000 9A Watermelon, juice 1.000000 1.000 1.000 20 Summer Full comment: Summer Squash, 10%CT 0902021000 9B Balsam pear 1.300000 1.000 1.000 Tolera Full comment: Tolerance, 100%CT 0902088000 9B Chayote, fruit 1.000000 1.000 1.000 24 Summer Full comment: Summer Squash, 100%CT 0902102000 9B Chinese waxgourd 1.300000 1.000 1.000 Tolera Full comment: Tolerance, 100%CT 0902135000 9B Cucumber 1.000000 1.000 1.000 21 Tolera Full comment: Tolerance, 5%CT 0902308000 9B Pumpkin 1.000000 1.000 1.000 20 Summer Full comment: Summer Squash, 10%CT 0902309000 9B Pumpkin, seed 0.130000 1.000 1.000 Summer Full comment: Summer Squash, Blend 0902356000 9B Squash, summer 1.000000 1.000 1.000 22 Summer Full comment: Summer Squash, 15%CT 0902356001 9B Squash, summer-babyfood 1.000000 1.000 1.000 23 Summer Full comment: Summer Squash, 15%CT 0902357000 9B Squash, winter 1.000000 1.000 1.000 23 Winter Full comment: Winter Squash, 15%CT 0902357001 9B Squash, winter-babyfood 1.000000 1.000 1.000 23 Winter Full comment: Winter Squash, 15%CT 8601000000 86A Water, direct, all sources 1.000000 1.000 1.000 26 GW - N Full comment: GW - NC Plain; 3 x 6 lbs ai/A 8602000000 86B Water, indirect, all sources 1.000000 1.000 1.000 26 GW - N Full comment: GW - NC Plain; 3 x 6 lbs ai/A



### Acute Result File (Food Only)

US EPA Ver. 3.18, 03-08-dBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 34 of 47 DEEM-FCID ACUTE Analysis for BENSULIDE ACUTE FOOD ONLY NHANES 2003-2008 2-Day Residue file: BensulideDietary_FoodOnly_Acute_Refined PDP CT.r08 Adjustment factor #2 NOT used. Analysis Date: 11-24-2015/22:05:01 Residue file dated: 11-23-2015/17:14:30 Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports Two-Day Average Results Reported RAC/FF intake summed over 24 hours MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

95th Percentile 99th Percentile 99.9th Percentile Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:
0.000696 6.33 0.001359 12.35 0.003459 31.45 All Infants: 0.000877 7.97 0.002354 21.40 0.003299 29.99 Children 1-2:
0.001592 14.47 0.002775 25.22 0.004436 40.33 Children 3-5:
0.001544 14.04 0.003278 29.80 0.005016 45.60 Children 6-12:
0.000991 9.01 0.001544 14.04 0.003835 34.86 Youth 13-19: 0.000570 5.19 0.001001 9.10 0.002713 24.66 Adults 20-49: 0.000585 5.32 0.001041 9.46 0.002241 20.37 Adults 50-99: 0.000545 0.50 0.001090 0.99 0.002124 1.93 Female 13-49: 0.000588 5.35 0.001031 9.37 0.002685 24.41



### Acute Result File (Water Only)

US EPA Ver. 3.18, 03-08-d DEEM-FCID ACUTE Analysis for BENSULIDE: WATER ONLY NHANES 2003-2008 2-Day Residue file: Bensulide_Acute_WaterOnly.r08 Adjustment factor #2 used. Analysis Date: 10-08-2015/16:24:53 Residue file dated: 10-08-2015/16:11:37 Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports RAC/FF intake summed over 24 hours MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

95th Percentile 99th Percentile 99.9th Percentile Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:
2.275922 >10000 4.046847 >10000 7.678216 >10000 All Infants: 7.520635 >10000 11.499234 >10000 18.020687 >10000 Children 1-2:
3.520924 >10000 6.124869 >10000 11.541166 >10000 Children 3-5:
2.912255 >10000 4.816625 >10000 8.169168 >10000 Children 6-12:
2.059751 >10000 3.860208 >10000 6.741665 >10000 Youth 13-19: 1.814217 >10000 3.420254 >10000 6.203782 >10000 Adults 20-49:Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 35 of 47 2.308230 >10000 3.812519 >10000 5.926093 >10000 Adults 50-99: 2.124412 1931.28 3.368625 3062.39 5.466176 4969.25 Female 13-49: 2.351742 >10000 3.884979 >10000 5.809774 >10000



### Acute Result File (Food and Drinking Water NC Cotton)

US EPA Ver. 3.18, 03-08-d DEEM-FCID ACUTE Analysis for BENSULIDE ACUTE FOOD WATER NHANES 2003-2008 2-Day Residue file: BensulideDietary_FoodWater_Acute_Refined PDP CT.r08 Adjustment factor #2 NOT used. Analysis Date: 11-24-2015/21:54:15 Residue file dated: 11-23-2015/17:17:21 Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports Two-Day Average Results Reported RAC/FF intake summed over 24 hours MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

95th Percentile 99th Percentile 99.9th Percentile Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:
2.201028 >10000 3.639543 >10000 7.200738 >10000 All Infants: 7.243097 >10000 10.929485 >10000 15.584203 >10000 Children 1-2:
3.394754 >10000 5.353360 >10000 10.366006 >10000 Children 3-5:
2.651409 >10000 4.279348 >10000 6.774460 >10000 Children 6-12:
1.931826 >10000 3.301167 >10000 6.321278 >10000 Youth 13-19: 1.769030 >10000 2.879901 >10000 4.816789 >10000 Adults 20-49: 2.220606 >10000 3.384570 >10000 5.199845 >10000 Adults 50-99: 2.047669 1861.52 3.184493 2894.99 4.856943 4415.40 Female 13-49: 2.293809 >10000 3.465148 >10000 5.059084 >10000



### Acute Result File (Food and Dr inking Water CA Avocado)

US EPA Ver. 3.18, 03-08-d DEEM-FCID ACUTE Analysis for BENSULIDE ACUTE FOOD WATER NHANES 2003-2008 2-Day Residue file: BensulideDietary_FoodWater_Acute_Refined PDP CT_Lowest EDWC.r08 Adjustment factor #2 NOT used. Analysis Date: 11-24-2015/19:22:36 Residue file dated: 11-23-2015/17:18:16 Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports Two-Day Average Results Reported RAC/FF intake summed over 24 hours MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

95th Percentile 99th Percentile 99.9th Percentile Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- --------Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 36 of 47 Total US Population:
0.078179 710.72 0.133920 1217.46 0.259261 2356.91 All Infants: 0.246114 2237.40 0.392544 3568.58 0.617566 5614.24 Children 1-2:
0.118029 1072.99 0.200324 1821.13 0.381599 3469.08 Children 3-5:
0.094340 857.64 0.155515 1413.77 0.274069 2491.53 Children 6-12:
0.070203 638.21 0.119789 1088.99 0.214996 1954.51 Youth 13-19: 0.061743 561.30 0.104553 950.48 0.180075 1637.05 Adults 20-49: 0.077111 701.01 0.123741 1124.92 0.205208 1865.53 Adults 50-99: 0.072139 65.58 0.114941 104.49 0.187992 170.90 Female 13-49: 0.078766 716.05 0.125405 1140.05 0.202361 1839.65



### A.2.2. Steady State (Acute 2-d ay Average) Dietary Assessment

Steady State Input File

Filename: C:\Users\IEncarna\Dietary Assessments\Bensulide\BensulideDietary_FoodWater_SteadyState_Refined PDP CT.r08 Chemical: Bensulide Steady State (2-day Average) Food Water RfD(Chronic): 0 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .006 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 11-23-2015/17:19:05 Program ver. 3.16, 03-08-d

----------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis: Index Dist Parameter #1 Param #2 Param #3 Comment # Code

----- ---- ------------ -------- -------- ------- 1 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Carrot_1.rdf 2 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Carrot_BabyFood_2.rdf 3 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Onion_Bulb_3.rdf 4 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Leaf_100CT_4.rdf 5 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Head_5.rdf 6 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Leaf _6.rdf 7 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Head_100CT_7.rdf 8 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Leaf_10CT_8.rdf 9 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Spinach_Canned_9.rdf 10 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Spinach_Frozen_10.rdf 11 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Celery_11.rdf 12 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Head_25CT_12.rdf 13 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Head_5CT_13.rdf 14 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Lettuce_Fresh_Head_20CT_14.rdfBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 37 of 47 15 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Cauliflower_Tolerance_20CT_15.rdf 16 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Tomato_Cherry_16.rdf 17 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Pepper_Nonbell_17.rdf 18 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Squash_Summer_40CT_18.rdf 19 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Squash_Summer_30CT_19.rdf 20 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Squash_Summer_10CT_20.rdf 21 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Cucumber_Tolerance_5CT_21.rdf 22 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Squash_Summer_22.rdf 23 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Squash_Winter_Fresh_23.rdf 24 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Squash_Summer_100CT_24.rdf 25 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Onion_Bulb_25.rdf 26 6 C:\Users\IEncarna\Documents\IENCARNA\Dietary Assessments\Bensulide\rdf Files\Bensulide_SteadyState_NC Eastern Costal Plain.rdf

EPA Crop Commodity Name Def Res Adj.Factors RDLComment Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- ------- 0101078000 1AB Carrot 1.000000 1.000 1.000 1 Carrot Full comment: Carrot, 100%CT 0101078001 1AB Carrot-babyfood 1.000000 1.000 1.000 2 Carrot Full comment: Carrot BabyFood, 100%CT 0101079000 1AB Carrot, juice 1.000000 1.000 1.000 1 Carrot Full comment: Carrot, 100%CT 0301165000 3A Garlic, bulb 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 130-Uncooked; Dried; Cook Meth N/S 0.130000 1.000 1.000 Point Full comment: Point Est, Blend Onion, 100%CT 140-Uncooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 150-Uncooked; Cured etc; Cook Meth N/S 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 214-Cooked; Fresh or N/S; Fried/baked 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 215-Cooked; Fresh or N/S; Boiled/baked 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 220-Cooked; Frozen; Cook Meth N/S 1.000000 1.000 1.000 25 Onion,Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 38 of 47 Full comment: Onion, 100% CT 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 222-Cooked; Frozen; Boiled 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 230-Cooked; Dried; Cook Meth N/S 0.130000 1.000 1.000 Point Full comment: Point Est, Blend Onion, 100% CT 232-Cooked; Dried; Boiled 0.130000 1.000 1.000 Point Full comment: Point Est, Blend Onion, 100% CT 233-Cooked; Dried; Fried 0.130000 1.000 1.000 Point Full comment: Point Est, Blend Onion, 100% CT 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 242-Cooked; Canned; Boiled 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 250-Cooked; Cured etc; Cook Meth N/S 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 252-Cooked; Cured etc; Boiled 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 0301165001 3A Garlic, bulb-babyfood 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 0301237000 3A Onion, bulb 1.000000 1.000 1.000 3 Onion, Full comment: Onion, 20%CT 0301237001 3A Onion, bulb-babyfood 1.000000 1.000 1.000 3 Onion, Full comment: Onion, 20%CT 0301238000 3A Onion, bulb, dried 0.026000 9.000 1.000 Point Full comment: Point Est, Blend Onion 0301238001 3A Onion, bulb, dried-babyfood 0.026000 9.000 1.000 Point Full comment: Point Est, Blend Onion 0301338000 3A Shallot, bulb 1.000000 1.000 1.000 25 Onion, Full comment: Onion, 100% CT 0401005000 4A Amaranth, leafy 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401018000 4A Arugula 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401104000 4A Chrysanthemum, garland 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401133000 4A Cress, garden 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401134000 4A Cress, upland 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401138000 4A Dandelion, leaves 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401150000 4A Endive 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0401204000 4A Lettuce, head 1.000000 1.000 1.000 5 Head L Full comment: Head Lettuce, 40%CT 0401205000 4A Lettuce, leaf 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 40%CT 0401248000 4A Parsley, leaves 1.000000 1.000 1.000 6 Leaf L Full comment: Leaf Lettuce, 100%CT 0401313000 4A Radicchio 1.000000 1.000 1.000 7 Head L Full comment: Head Lettuce, 100%CT 0401355000 4A Spinach 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 212-Cooked; Fresh or N/S; BoiledBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 39 of 47 1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 215-Cooked; Fresh or N/S; Boiled/baked
1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 220-Cooked; Frozen; Cook Meth N/S 1.000000 1.000 1.000 10 Spinac Full comment: Spinach Frozen, 10%CT 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 10 Spinac Full comment: Spinach Frozen, 10%CT 222-Cooked; Frozen; Boiled 1.000000 1.000 1.000 10 Spinac Full comment: Spinach Frozen, 10%CT 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 8 Leaf L Full comment: Leaf Lettuce, 10%CT 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 9 Spinac Full comment: Spinach Canned, 10%CT 242-Cooked; Canned; Boiled 1.000000 1.000 1.000 9 Spinac Full comment: Spinach Canned, 10%CT 0401355001 4A Spinach-babyfood 1.000000 1.000 1.000 9 Spinac Full comment: Spinach Canned, 10%CT
0402076000 4B Cardoon 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0402085000 4B Celery 1.000000 1.000 1.000 11 Celery Full comment: Celery, 5%CT 0402085001 4B Celery-babyfood 1.000000 1.000 1.000 11 Celery Full comment: Celery, 5%CT 0402086000 4B Celery, juice 1.000000 1.000 1.000 11 Celery Full comment: Celery, 5%CT 0402087000 4B Celtuce 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0402152000 4B Fennel, Florence 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0402322000 4B Rhubarb 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0402367000 4B Swiss chard 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0501061000 5A Broccoli 1.000000 1.000 1.000 12 Head L Full comment: Head Lettuce, 25%CT 0501061001 5A Broccoli-babyfood 1.000000 1.000 1.000 12 Head L Full comment: Head Lettuce, 25%CT 0501062000 5A Broccoli, Chinese 1.300000 1.000 1.000 Tolera Full comment: Tolerance, 100%CT 0501064000 5A Brussels sprouts 1.000000 1.000 1.000 13 Head L Full comment: Head Lettuce, 5%CT 0501069000 5A Cabbage 1.000000 1.000 1.000 14 Head L Full comment: Head Lettuce, 20%CT 0501071000 5A Cabbage, Chinese, napa 1.300000 1.000 1.000 Tolera Full comment: Tolerance, 100%CT 0501072000 5A Cabbage, Chinese, mustard 1.300000 1.000 1.000 Tolera Full comment: Tolerance, 100%CT 0501083000 5A Cauliflower 1.000000 1.000 1.000 15 Tolera Full comment: Tolerance, 20%CT 0501196000 5A Kohlrabi 1.300000 1.000 1.000 Tolera Full comment: Tolerance, 100%CT 0502063000 5B Broccoli raab 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0502070000 5B Cabbage, Chinese, bok choy 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0502117000 5B Collards 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0502194000 5B Kale 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0502229000 5B Mustard greens 1.000000 1.000 1.000 4 Leaf LBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 40 of 47 Full comment: Leaf Lettuce, 100%CT 0502318000 5B Rape greens 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0502389000 5B Turnip, greens 1.000000 1.000 1.000 4 Leaf L Full comment: Leaf Lettuce, 100%CT 0801374000 8A Tomatillo 1.000000 1.000 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0801375000 8A Tomato 1.000000 1.000 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0801375001 8A Tomato-babyfood 1.000000 1.000 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0801376000 8A Tomato, paste 0.100000 5.400 1.000 Point Full comment: Point Est, Blend, Tomato 0801376001 8A Tomato, paste-babyfood 0.100000 5.400 1.000 Point Full comment: Point Est, Blend, Tomato 0801377000 8A Tomato, puree 0.100000 3.300 1.000 Point Full comment: Point Est, Blend, Tomato 0801377001 8A Tomato, puree-babyfood 0.100000 3.300 1.000 Point Full comment: Point Est, Blend, Tomato 0801378000 8A Tomato, dried 0.100000 14.300 1.000 Point Full comment: Point Est, Blend, Tomato 0801378001 8A Tomato, dried-babyfood 0.100000 14.300 1.000 Point Full comment: Point Est, Blend, Tomato 0801379000 8A Tomato, juice 0.100000 1.500 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0801380000 8A Tomato, Tree 1.000000 1.000 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0802148000 8BC Eggplant 1.000000 1.000 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0802234000 8BC Okra 1.000000 1.000 1.000 16 Cherry Full comment: Cherry Tomato, 100%CT 0802270000 8B Pepper, bell 1.000000 1.000 1.000 17 Hot Pe Full comment: Hot Pepper, 10%CT 0802270001 8B Pepper, bell-babyfood 1.000000 1.000 1.000 17 Hot Pe Full comment: Hot Pepper, 10%CT 0802271000 8B Pepper, bell, dried 0.005100 1.000 1.000 Point Full comment: Point Est, Blend, Pepper 0802271001 8B Pepper, bell, dried-babyfood 0.005100 1.000 1.000 Point Full comment: Point Est, Blend, Pepper 0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 17 Hot Pe Full comment: Hot Pepper, 10%CT 0802272001 8BC Pepper, nonbell-babyfood 1.000000 1.000 1.000 17 Hot Pe Full comment: Hot Pepper, 10%CT 0802273000 8BC Pepper, nonbell, dried 0.005100 1.000 1.000 Point Full comment: Point Est, Blend, Pepper 0901075000 9A Cantaloupe 1.000000 1.000 1.000 18 Summer Full comment: Summer Squash, 40%CT 0901187000 9A Honeydew melon 1.000000 1.000 1.000 19 Summer Full comment: Summer Squash, 30%CT 0901399000 9A Watermelon 1.000000 1.000 1.000 20 Summer Full comment: Summer Squash, 10%CT 0901400000 9A Watermelon, juice 1.000000 1.000 1.000 20 Summer Full comment: Summer Squash, 10%CT 0902021000 9B Balsam pear 1.300000 1.000 1.000 Tolera Full comment: Tolerance, 100%CT 0902088000 9B Chayote, fruit 1.000000 1.000 1.000 24 Summer Full comment: Summer Squash, 100%CT 0902102000 9B Chinese waxgourd 1.300000 1.000 1.000 Tolera Full comment: Tolerance, 100%CT 0902135000 9B Cucumber 1.000000 1.000 1.000 21 Tolera Full comment: Tolerance, 5%CT 0902308000 9B Pumpkin 1.000000 1.000 1.000 20 Summer Full comment: Summer Squash, 10%CT 0902309000 9B Pumpkin, seed 0.130000 1.000 1.000 Summer Full comment: Summer Squash, Blend 0902356000 9B Squash, summer 1.000000 1.000 1.000 22 Summer Full comment: Summer Squash, 15%CTBensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 41 of 47 0902356001 9B Squash, summer-babyfood 1.000000 1.000 1.000 23 Summer Full comment: Summer Squash, 15%CT 0902357000 9B Squash, winter 1.000000 1.000 1.000 23 Winter Full comment: Winter Squash, 15%CT 0902357001 9B Squash, winter-babyfood 1.000000 1.000 1.000 23 Winter Full comment: Winter Squash, 15%CT 8601000000 86A Water, direct, all sources 1.000000 1.000 1.000 26 GW - 2 Full comment: GW - 21-day rolling av; NC Plain; 3 x 6 lbsai/A 8602000000 86B Water, indirect, all sources 1.000000 1.000 1.000 26 GW - 2 Full comment: GW - 21-day rolling av; NC Plain; 3 x 6 lbsai/A



### Steady State Result File (Food Only)

US EPA Ver. 3.18, 03-08-d DEEM-FCID ACUTE Analysis for BENSULIDE STEADY STATE (2-DAY AVERAGE) FOOD ONLY NHANES 2003-2008 2-Day Residue file: BensulideDietary_FoodOnly_SteadyState_Refined PDP CT.r08 Adjustment factor #2 NOT used. Analysis Date: 11-24-2015/19:10:44 Residue file dated: 11-23-2015/17:16:03 Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports Two-Day Average Results Reported RAC/FF intake summed over 24 hours MC iterations = 2000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

95th Percentile 99th Percentile 99.9th Percentile Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:
0.000696 11.61 0.001360 22.67 0.003454 57.57 All Infants: 0.000875 14.58 0.002355 39.24 0.003322 55.37 Children 1-2:
0.001593 26.55 0.002774 46.23 0.004436 73.93 Children 3-5:
0.001541 25.69 0.003277 54.61 0.004779 79.65 Children 6-12:
0.000990 16.50 0.001544 25.73 0.003836 63.93 Youth 13-19: 0.000571 9.51 0.001001 16.69 0.002710 45.17 Adults 20-49: 0.000586 9.76 0.001041 17.35 0.002240 37.33 Adults 50-99: 0.000545 0.91 0.001093 1.82 0.002128 3.55 Female 13-49: 0.000589 9.81 0.001031 17.18 0.002687 44.79



### Steady State Result File (Water Only)

US EPA Ver. 3.18, 03-08-d DEEM-FCID ACUTE Analysis for BENSULIDE: WATER ONLY NHANES 2003-2008 2-Day Residue file: Bensulide_SteadyState_WaterOnly.r08 Adjustment factor #2 used. Analysis Date: 10-08-2015/16:34:30 Residue file dated: 10-08-2015/16:12:33 Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports Two-Day Average Results Reported RAC/FF intake summed over 24 hours MC iterations = 2000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: ""

===============================================================================Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 42 of 47 Summary calculations--per capita:

95th Percentile 99th Percentile 99.9th Percentile Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:
2.198112 >10000 3.638341 >10000 7.201506 >10000 All Infants: 7.242605 >10000 10.919091 >10000 15.562427 >10000 Children 1-2:
3.393080 >10000 5.337693 >10000 10.362899 >10000 Children 3-5:
2.647587 >10000 4.276408 >10000 6.791597 >10000 Children 6-12:
1.937966 >10000 3.296448 >10000 6.319859 >10000 Youth 13-19: 1.770270 >10000 2.877123 >10000 4.794140 >10000 Adults 20-49: 2.217461 >10000 3.378742 >10000 5.198223 >10000 Adults 50-99: 2.043202 3405.34 3.180071 5300.12 4.856147 8093.58 Female 13-49: 2.292162 >10000 3.461474 >10000 5.057977 >10000



### Steady State Result File (Food a nd Drinking Water NC Cotton)

US EPA Ver. 3.18, 03-08-d DEEM-FCID ACUTE Analysis for BENSULIDE STEADY STATE (2-DAY AVERAGE) FOOD WATER NHANES 2003-2008 2-Day Residue file: BensulideDietary_FoodWater_SteadyState_Refined PDP CT.r08 Adjustment factor #2 NOT used. Analysis Date: 11-24-2015/18:53:00 Residue file dated: 11-23-2015/17:19:05 Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports Two-Day Average Results Reported RAC/FF intake summed over 24 hours MC iterations = 2000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

95th Percentile 99th Percentile 99.9th Percentile Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:
2.198048 >10000 3.636428 >10000 7.197920 >10000 All Infants: 7.244892 >10000 10.954358 >10000 15.581721 >10000 Children 1-2:
3.389774 >10000 5.327526 >10000 10.393019 >10000 Children 3-5:
2.649702 >10000 4.285735 >10000 6.795017 >10000 Children 6-12:
1.934804 >10000 3.289967 >10000 6.315285 >10000 Youth 13-19: 1.769910 >10000 2.880795 >10000 4.781498 >10000 Adults 20-49: 2.217875 >10000 3.375879 >10000 5.194808 >10000 Adults 50-99: 2.041901 3403.17 3.178268 5297.11 4.851935 8086.56 Female 13-49: 2.288939 >10000 3.459970 >10000 5.053817 >10000Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 43 of 47 

### Steady State Result File (Food a nd Drinking Water CA Avocado)

US EPA Ver. 3.18, 03-08-d DEEM-FCID ACUTE Analysis for BENSULIDE STEADY STATE (2-DAY AVERAGE) FOOD WATER NHANES 2003-2008 2-Day Residue file: BensulideDietary_FoodWater_SteadyState_Refined PDP CT_Lowest EDWC.r08 Adjustment factor #2 NOT used. Analysis Date: 11-24-2015/18:38:00 Residue file dated: 11-23-2015/17:19:50 Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports Two-Day Average Results Reported RAC/FF intake summed over 24 hours MC iterations = 2000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

95th Percentile 99th Percentile 99.9th Percentile Exposure % aPAD Exposure % aPAD Exposure % aPAD

---------- -------- ---------- -------- ---------- -------- Total US Population:
0.077789 1296.48 0.132508 2208.47 0.256468 4274.47 All Infants: 0.245876 4097.93 0.387208 6453.46 0.603403 >10000 Children 1-2:
0.117663 1961.04 0.199239 3320.65 0.378531 6308.86 Children 3-5:
0.094079 1567.98 0.153828 2563.80 0.267948 4465.79 Children 6-12:
0.069838 1163.97 0.118744 1979.07 0.212895 3548.26 Youth 13-19: 0.061559 1025.98 0.103514 1725.23 0.176266 2937.77 Adults 20-49: 0.076713 1278.55 0.122406 2040.11 0.200449 3340.83 Adults 50-99: 0.071774 119.62 0.113156 188.59 0.182459 304.10 Female 13-49: 0.078247 1304.12 0.123796 2063.27 0.196688 3278.14Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 44 of 47 

### Attachment 3. Critical Exposure Cont ribution Analysis for Food Only

Acute CEC Result File (Children 3-5 years)

US EPA DEEM-FCID Acute Critical Exposure Contribution Analysis (Ver. 3.18, 03-08-d) NHANES 2003-2008 2-Day Residue file = C:\Users\IEncarna\Dietary Assessments\Bensulide\BensulideDietary_FoodOnly_Acute_Refined PDP CT.r08 Date and time of analysis: 11-24-2015 21:58:36 Daily totals for food and foodform consumption used. Adjustment factor #2 not used. Minimum exposure contribution = 5% MC Iterations = 1000 Seed = 10 RNG = MS VB Exposures divided by body weight Children 3-5 Low percentile for CEC records: 99.9 Exposure (mg/day) = 0.005016 High percentile for CEC records: 100 Exposure (mg/day) = 0.027683 Number of actual records in this interval: 1007

Critical foods (without foodforms) for this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent of total exposure for all records (including duplicates)

Food N Percent Food Name

---------- ----- ------- ------------- 0902135000 809 60.05% Cucumber 0901399000 115 9.27% Watermelon 0801377000 485 5.84% Tomato, puree 0501061000 24 2.76% Broccoli 0801379000 195 2.59% Tomato, juice 0502117000 18 2.49% Collards 0401355000 26 2.16% Spinach 0502229000 15 2.13% Mustard greens 0801376000 133 1.54% Tomato, paste 0502389000 6 1.30% Turnip, greens 0501069000 8 0.84% Cabbage 0401204000 12 0.81% Lettuce, head 0801375000 114 0.71% Tomato 0401205000 9 0.49% Lettuce, leaf 0901075000 20 0.24% Cantaloupe 0501083000 3 0.09% Cauliflower 0401150000 3 0.07% Endive 0402085000 3 0.02% Celery 0101078000 3 0.01% Carrot 0901187000 2 0.01% Honeydew melon



### Steady State (Acute 2-day Average) Result File (Children 3-5 years)

US EPA DEEM-FCID Acute Critical Exposure Contribution Analysis (Ver. 3.18, 03-08-d) NHANES 2003-2008 2-Day Residue file = C:\Users\IEncarna\Dietary Assessments\Bensulide\BensulideDietary_FoodOnly_SteadyState_Refined PDP CT.r08 Date and time of analysis: 11-24-2015 18:58:41 Daily totals for food and foodform consumption used. Adjustment factor #2 not used. Minimum exposure contribution = 5% MC Iterations = 2000 Seed = 10 RNG = MS VB CEC records generated for first 1624 iterations. Exposures divided by body weight

Children 3-5 Low percentile for CEC records: 99.9 Exposure (mg/day) = 0.004779Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 45 of 47 High percentile for CEC records: 100 Exposure (mg/day) = 0.022028 Number of actual records in this interval: 1773

Critical foods (without foodforms) for this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent of total exposure for all records (including duplicates)

Food N Percent Food Name

---------- ----- ------- ------------- 0902135000 1414 59.88% Cucumber 0901399000 206 9.43% Watermelon 0801377000 809 5.56% Tomato, puree 0401355000 61 3.25% Spinach 0501061000 49 3.06% Broccoli 0801379000 336 2.55% Tomato, juice 0801376000 316 2.18% Tomato, paste 0502229000 17 1.67% Mustard greens 0502117000 20 1.15% Collards 0801375000 246 1.06% Tomato 0401205000 30 0.96% Lettuce, leaf 0502389000 8 0.74% Turnip, greens 0501069000 16 0.73% Cabbage 0401204000 13 0.42% Lettuce, head 0901075000 33 0.23% Cantaloupe 0502194000 4 0.21% Kale 0401150000 15 0.17% Endive 0402085000 22 0.07% Celery 0501064000 1 0.03% Brussels sprouts 0501083000 1 0.02% Cauliflower
0101078000 4 0.01% Carrot 0902356000 1 0.01% Squash, summerBensulide Dietary Exposure and Ri sk Assessment DP Number: D428878

Page 46 of 47 

### Attachment 4. Screening Leve l Estimates for Bensulide.

Biological and Economic Analysis Division; J. Al sadek; Updated Screening Level Usage Analysis (SLUA) Report for Bensulide, PC Code (009801); 07/10/2015.Bensulide Dietary Exposure and Risk Assessment DP Number: D428878

Page 47 of 47 

### Attachment 5. EDWC at the LOC Considering Exposure through Drinking Water Only

A screening tool was used to provi de a quick estimate of the cont ribution of pesticide residues in drinking water to the dietary risk of the pesticide. Rough esti mates of the estimated drinking water concentration (EDWC) at the level of concern (LOC) are provide d without considering contribution from food and residential exposures. Therefore, even if estimated drinking water risks are relatively low, aggregate risk may be of concern. The water consumption values were obtained using the dietary exposure and risk model, DEEM-FCID Version 4.02, which uses food consumption data from the USDA National Health and Nutrition Examina tion Survey, What We Eat in America, conducted from 2005 to 2010; refe r to Table A.6.2. In general, the population subgroup with higher exposure to re sidues in drinking water is infa nts (<1 yr old). The equation used to estimate the dietary risk and the results of the screening are presented below.

The lowest EDWC at the level of concern is 20 ppb. Considering bensulide’s oxon toxicity adjustment factor of 50x, the target EDWC at the LOC considering exposure through drinking water only is about 0.4 ppb. Is important to not e that a distribution of water residues may be used for dietary assessment purposes; therefore, the distribution from mo deling a scenario that results in a peak concentration of 0.4 ppb may result in lower diet ary risk than that obtained using a point estimate.

Table A.6.1. Results of the screening of the Dietary Risk Contribution from Drinking Water

Assessment Population aPAD and ssPAD (mg/kg/day) EDWC at LOC (ppb)
95 th 

### 99.9 th



### Acute General 0.011 206.7669 61.11111

All Infants 0.011 60.10929 32.35294

Females 0.011 209.1255 95.65217

Steady State General 0.006 122.1996 34.28571
All Infants 0.006 32.78689 20.20202 Females 0.006 123.9669 63.55932 Equation to estimate the dietary risk:

Table A.6.2. Water consumption (L / kg-bw*day) for Acute and Steady State

Population Subgroup Acute Steady State 1



### 95 th 

### 99.9 th 

### 95 th 

### 99.9 th 

### General Population 0.0532 0.180 0.0491 0.175
All Infants (< 1yr old) 0.183 0.340 0.183 0.297
Females (13-49 yrs) 0.0526 0.115 0.0484 0.0944

1 The water consumption for steady state was obtained using the two-day average consumption from individuals participating in the WWEIA survey.

ܦܣ%ܿܲ	ݎ݋	ܦܣܲݏݏ% ,ܦܣ%ܽܲ ሺ ݎ݁ݐܹܽ ሻ ൌ ሺ ݕ/݀ܽݓ/ܾ݇݃ܮ ݊,݋݅ݐ݌݉ݑݏ݊݋ܥ ݎ݁ݐܹܽ ሻሺ ܾ݌݌ ,ܥܹܦܧ ሻ ൬1000 μg mg ሺ ൰ ݕ݉݃/݇݃/݀ܽ ,ܦܣܿܲ ݎ݋ ܦܣܲݏݏ ,ܦܣܽܲ ሻ 100ݔ