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                                                                   Exhibit 10.16

                        MASTER EQUIPMENT LEASE AGREEMENT

NO. 7667                                                     DATED June 10, 1999

   Lessor:                                    Lessee:
   OXFORD VENTURE FINANCE, LLC                GENAISSANCE PHARMACEUTICALS, INC.
   a Virginia limited liability corporation   a Delaware corporation

   Address:                                   Address:
         133 NORTH FAIRFAX STREET                   FIVE SCIENCE PARK
         ALEXANDRIA, VIRGINIA 22314                 NEW HAVEN, CT 06511

            Subject to the terms and conditions set forth herein and in any
Lease Schedule, Lessor agrees to lease to Lessee, and Lessee agrees to lease
from Lessor each item of Equipment specified on a Lease Schedule and Lessee
grants to Lessor the following rights:

            1. DEFINITIONS. To the extent not otherwise specifically defined in
this Agreement, unless the context otherwise requires, all other terms contained
in this Agreement shall have the meanings assigned or referred to them in the
UCC. The following terms shall have the following meanings:

            "Acceptance Certificate" with respect to each item of Equipment
shall mean a certificate in the form satisfactory to Lessor, executed by Lessee
to evidence acceptance by Lessee of the Equipment to which such certificate
relates.

            "Acceptance Date" with respect to each item of Equipment shall have
the meaning assigned to such term in Section 3 of this Agreement.

            "Affiliate" shall mean, with respect to any person, firm or entity,
any other person, firm or entity controlling, controlled by, or under common
control with such person, firm or entity; for the purposes hereof "control"
shall mean the possession, directly or indirectly, of the power to direct or
cause the direction of the management and policies of any such person, firm or
entity, whether through the legal or beneficial ownership of voting securities,
by contract or otherwise.

            "Agreement" shall mean this Master Equipment Lease Agreement, as
amended or modified from time to time.

            "Attorneys' Fees and Expenses" shall mean all reasonable attorneys'
fees and legal costs and expenses (including, without limitation, those fees,
costs and expenses incurred in connection with bankruptcy proceedings, including
Relief from Stay Motions, Cash Collateral Motions and disputes concerning any
proposed disclosure statement and/or bankruptcy plan).

            "Collateral" shall mean all Equipment and any licenses, trademarks
or other tangible or intangible property ancillary to the Equipment and all
products, proceeds, rents and profits therefrom or thereof, including proceeds
in the form of goods, accounts, chattel paper, documents, instruments and
insurance proceeds.

            "Default" shall have the meaning ascribed to such term in Section 10
of this Agreement.

            "Equipment" shall mean one or more items or units of personal
property, leased by Lessor to Lessee hereunder, as described in each Lease
Schedule wherever the same may be located, including all present and future
additions, attachments, accessions and accessories thereto and all replacements,
substitutions and a right to use license for any software related to any of the
foregoing and proceeds thereof, including all proceeds of insurance thereon.

            "Event of Default" shall have the meaning ascribed to such term in
Section 10 of this Agreement.

            "Lease" shall mean the applicable Lease Schedule incorporating the
terms and conditions of this Agreement, including all exhibits, addenda,
schedules, certificates, riders and all other documents and instruments executed
and delivered in connection with the applicable Lease Schedule or this Master
Equipment Lease Agreement.


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            "Lease Schedule" shall mean each Lease Schedule, which incorporates
by reference the terms and conditions of this Agreement and describes one or
more items of Equipment and specific terms and conditions with respect thereto.

            "Lease Term" with respect to each item of Equipment shall have the
meaning assigned to such term in the Lease Schedule applicable to such item of
Equipment.

            "Lease Term Commencement Date" with respect to each item of
Equipment shall have the meaning assigned to such term in the Lease Schedule
applicable to such item of Equipment.

            "Obligations" shall mean all liabilities, absolute or contingent,
joint, several or independent, of Lessee or any Affiliate of Lessee now or
hereafter existing, due or to become due to, or held or to be held by, Lessor
for its own account or as agent for another or others, whether created directly
or acquired by assignment or otherwise and howsoever evidenced, including,
without limitation, the Lease, and all rent, taxes, fees, charges, expenses and
Attorneys' Fees and Expenses chargeable to Lessee or incurred by Lessor under
the Lease, or any other document or instrument delivered in connection herewith.

            "Person" shall mean any individual, partnership, joint venture,
firm, corporation, association, trust, or other enterprise or any government or
political subdivision or any agency, department or instrumentality thereof.

            "Rental Payment" with respect to each item of Equipment shall have
the meaning assigned to such term in the Lease Schedule applicable to such item
of Equipment.

            "Rental Payment Date" with respect to each item of Equipment shall
have the meaning assigned to such term in the Lease Schedule applicable to such
item of Equipment.

            "Security Deposit" with respect to each item of Equipment shall have
the meaning assigned to such term in the Lease Schedule applicable to such item
of Equipment.

            "UCC" shall mean the Uniform Commercial Code as enacted in the State
of Connecticut.

            2. INDEPENDENT LEASE; CROSS-COLLATERALIZATION; SECURITY INTEREST.
Each Lease Schedule shall constitute a separate, distinct and independent Lease
of Equipment and contractual obligation of Lessee. As security for the due and
punctual payment of any and all of the present and future Obligations of Lessee
to Lessor, and without prejudice to Lessor's ownership interest in the
Collateral, Lessee hereby (i) grants to Lessor with respect to each Lease and
for the full amount of all Obligations, a security interest in all of the
Collateral and all collateral securing any other lease or security agreement
between Lessee and Lessor, whether now in existence or hereafter entered into
and (ii) assigns to Lessor all of its rights, title and interest in surplus
money to which Lessee may be entitled upon the sale of all such Collateral. The
extent to which Lessor shall have a purchase money security interest in any item
of Collateral under a Lease which is deemed to create a security interest under
the UCC shall be determined by reference to the Acquisition Cost of such item
financed by Lessor and the aggregate amount of all Obligations under the Lease.

            3. ACCEPTANCE OF EQUIPMENT. The Equipment is to be delivered and
installed at the location specified or referred to in the applicable Lease
Schedule. The Equipment shall be deemed to have been accepted by Lessee for all
purposes under this Lease upon Lessee's execution of an Acceptance Certificate
with respect to such Equipment (the "Acceptance Date"). Lessor shall not be
liable or responsible for any failure or delay in the delivery of the Equipment
to Lessee for whatever reason.

            4. TERM AND RENT; NON-CANCELABLE; LATE CHARGES. The Lease Term for
any Lease shall be as specified in the applicable Lease Schedule. Upon Lessee's
acceptance of Equipment under a Lease, the Lease shall be noncancelable. The
obligations of Lessee to pay rent and all other amounts when due and to perform
as required under the Lease are unconditional and irrevocable and are not
subject to cancellation, termination, prepayment, modification, repudiation,
revocation or excuse. The Lease is a net Lease. Lessee shall not be entitled to
any abatement, reduction, offset or counterclaim with respect to its obligations
under the Lease for any reason whatsoever, whether arising out of claims against
the Lessor, the manufacturer or supplier, defect in, lack of fitness for use,
loss of possession or use of or damage or destruction of the Equipment or
otherwise. Rental Payments shall be in the amounts and shall be due and payable
as set forth in the applicable


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Lease Schedule. Lessee shall, in addition, pay interim rent to Lessor on a
pro-rata, per-diem basis from the Acceptance Date to the Lease Term Commencement
Date set forth in the applicable Lease Schedule, payable on such Lease Term
Commencement Date. If any rent or other amount payable hereunder shall not be
paid within 5 days of the date when due, Lessee shall pay as an administrative
and late charge an amount equal to 5% of the amount of any such overdue payment.
In addition, Lessee shall pay overdue interest on any delinquent payment or
other amounts due under the Lease (by reason of acceleration or otherwise) from
the due date until paid at the rate of one and one-half percent (1.5%) per month
or the maximum amount permitted by applicable law, whichever is lower. All
payments to be made to Lessor shall be made to Lessor in immediately available
funds at the address shown above, or at such other place as Lessor shall specify
in writing.

            5. POSSESSION; PERSONAL PROPERTY. No right, title or interest in the
Equipment shall pass to Lessee other than the right to maintain possession and
use of the Equipment for the Lease Term (provided no Event of Default has
occurred) free from interference by any person claiming by, through, or under
Lessor. The Equipment shall always remain personal property even though the
Equipment may hereafter become attached or affixed to real property.

            6. REPRESENTATIONS, WARRANTIES AND COVENANTS. Lessee hereby
represents and warrants to and covenants with Lessor (provided that if Lessee is
an individual or sole proprietorship, the representations, warranties and
covenants relating to corporate status shall not apply) that, as of the date
hereof and for so long as any Obligations shall remain outstanding:

            (a) Lessee is duly organized and is existing in good standing under
the laws of its jurisdiction of organization and is duly qualified and in good
standing in those jurisdictions where the conduct of its business or the
ownership of its properties requires qualification;

            (b) Lessee has the power and authority to enter into and perform the
Lease and any other document or instrument delivered in connection herewith and
to incur the Obligations;

            (c) Lessee's chief executive office is located at the address set
forth above;

            (d) Lessee does not utilize, and has not in the last five years
utilized, any trade names in the conduct of its business except as set forth on
Schedule 1 hereto;

            (e) Lessee has not changed its name, been the surviving entity in a
merger, acquired any business; or changed the location of its chief executive
office within the previous five years, except as set forth on Schedule 2 hereto;

            (f) Neither the execution, delivery or performance by Lessee of the
Lease nor compliance by it with the terms and provisions hereof, nor the
consummation of the transactions contemplated herein, (i) will contravene any
applicable provision of any law, statute, rule or regulation, or any order,
writ, injunction or decree of any court or governmental instrumentality, (ii)
will conflict or be inconsistent with or result in any breach of any of the
terms, covenants, conditions or provisions of, or constitute a default under, or
result in any lien upon any property, pursuant to the terms of any indenture,
mortgage, deed of trust, loan agreement or any other material agreement or
instrument to which Lessee is a party or by which it or any of its property or
assets are bound or to which it may be subject or (iii) will violate any
provision of its Certificate of Incorporation or By-Laws, or other governance
documents.

            (g) The Lease and any document or instrument delivered in connection
herewith and the transactions contemplated hereby or thereby are duly
authorized, executed and delivered, and the Lease and such other documents and
instruments constitute valid and legally binding obligations of Lessee and are
enforceable against Lessee in accordance with their respective terms;

            (h) No order, consent, approval, license, authorization, or
validation of, or filing, recording or registration with, or exemption by any
governmental or public body or authority, or any subdivision thereof, is
required to authorize or required in connection with (i) the execution, delivery
and performance of the Lease or (ii) the legality, validity, binding effect or
enforceability of the Lease.

            (i) Lessee has filed all federal, state and local tax returns and
other reports it is required to file, has paid or made adequate provision for
payment of all such taxes, assessments and other governmental charges, shall pay
or deposit


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promptly when due all sales, use, excise, personal property, income,
withholding, corporate, franchise and other taxes, assessments and governmental
charges upon or relating to the manufacture, purchase, ownership, maintenance,
modification, delivery, installation, possession, condition, use, acceptance,
rejection, operation or return of the Equipment and, upon request by Lessor,
Lessee will submit to Lessor proof satisfactory to Lessor that such payments
and/or deposits have been made;

            (j) There are no pending or threatened actions or proceedings before
any court or administrative agency, an unfavorable resolution of which could
have a material adverse effect on Lessee's financial condition or operations;

            (k) No representation, warranty or statement by Lessee contained in
the Lease or in any certificate or other document furnished or to be furnished
by Lessee pursuant to the Lease contains or at the time of delivery shall
contain any untrue statement of material fact, or omits, or shall omit at the
time of delivery, to state a material fact necessary to make it not misleading;

            (l) All financial statements delivered and to be delivered by Lessee
to Lessor in connection with the execution and delivery of the Lease are true
and correct in all material respects and have been prepared in accordance with
generally accepted accounting principles, and at all times since the date of the
most recent financial statements, there has been no material change in Lessee's
financial affairs or business operations. Lessee shall furnish Lessor: (i)
within 120 days after the last day of each fiscal year of Lessee, a financial
statement including a balance sheet, income statement, statement of retained
earnings and statement of cash flows, each prepared in accordance with generally
accepted accounting principles consistently applied with a report signed by an
independent certified public accountant satisfactory to Lessor; (i) upon the
request of Lessor, within 45 days after the close of each quarter of each fiscal
year of Lessee, financial statements similar to those described in the
immediately preceding clause, prepared by Lessee and certified by the chief
financial officer of Lessee; (iii) promptly upon the request of Lessor, such tax
returns or financial statements regarding any guarantor of the Obligations or
any Affiliate of Lessee as Lessor may reasonably request from time to time; (iv)
promptly upon request of Lessor, in form satisfactory to Lessor, such other and
additional information as Lessor may reasonably request from time to time, and;
(v) promptly inform Lessor of any Defaults (defined below) or any events or
changes in the financial condition of Lessee occurring since the date of the
last financial statements of Lessee delivered to Lessor which, individually or
cumulatively, when viewed in light of prior financial statements, may result in
a material adverse change in the financial condition of Lessee;

            (m) Lessee shall permit Lessor, through its authorized attorneys,
accountants and representatives, to inspect and examine the Equipment and the
books, accounts, records, ledgers and assets of every kind and description of
Lessee with respect thereto at all reasonable times; provided, however, that the
failure of Lessor to inspect the Equipment or to inform Lessee of any
noncompliance shall not relieve Lessee of any of its Obligations hereunder; and;

            (n) The Equipment is personal property and not a fixture under the
law of the jurisdiction in which the Equipment is located even though the
Equipment may hereafter become attached or affixed to real property;

            (o) Each site where Equipment is located, if not owned by Lessee, is
leased by Lessee pursuant to a valid lease or rental agreement which permits the
possession, use and operation of the Equipment at such location;

            (p) Lessee shall provide Lessor with disclaimers and waivers from
landlords, mortgagees and other persons holding any interest or claim in and to
any premises where Equipment is located, acceptable in all respects to Lessor,
which may be necessary or advisable in the reasonable discretion of Lessor to
confirm that the rights of Lessor in the Equipment are and will remain valid and
superior against all other parties;

            (q) The Equipment is in the possession of Lessee at the location(s)
specified in the applicable Lease Schedule, and shall not be removed from such
location without the prior written consent of Lessor, which consent shall in any
event be conditioned upon Lessee having completed all notifications, filings,
recordings, and other actions in such new location as Lessor may require to
protect and perfect Lessor's interests in the Collateral;

            (r) Lessee shall not, without the prior written consent of Lessor,
sell, offer to sell, lease, rent, hire or in any other manner dispose, transfer
or surrender use and possession of any Equipment;


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            (s) Lessee will not, directly or indirectly, create, incur or permit
to exist any lien, encumbrance, mortgage, pledge, attachment or security
interest on or with respect to the Equipment other than in connection with the
execution and delivery of the Lease;

            (t) Lessee shall permit each item of Equipment to be used only
within the continental United States by qualified personnel solely for business
purposes and the purpose for which it was designed and, at its sole expense,
shall service, repair, overhaul and maintain each item of Equipment in the same
condition as when received, ordinary wear and tear excepted, in good operating
order, consistent with prudent industry practice (but, in no event less than the
same extent to which Lessee maintains other similar equipment in the prudent
management of its assets and properties) and in compliance with all applicable
laws, ordinances, regulations, and conditions of all insurance policies required
to be maintained by Lessee under the Lease and all manuals, orders,
recommendations, instructions and other written requirements as to the repair
and maintenance of such item of Equipment issued at any time by the vendor
and/or manufacturer thereof;

            (u) If any item of Equipment does not comply with the requirements
of the Lease, Lessee shall bring such Equipment into compliance with the
provisions hereof; and Lessee shall not use any Equipment, nor allow the same to
be used, for any unlawful purpose;

            (v) Lessee acknowledges that Lessor has not selected, manufactured
or supplied the Equipment to Lessee and has acquired any Equipment subject
hereto solely in connection with this Lease and Lessee has received and approved
the terms of any purchase order or agreement with respect to the Equipment; and

            (w) Lessee has all permits, licenses and other authorizations which
are required with respect to its business under Environmental Laws (as defined
below) and is in compliance with all terms and conditions of such permits,
licenses and other authorizations, including all limitations, restrictions,
standards, prohibitions, requirements, obligations, schedules and timetables.
The Lessee is not presently in violation of any Environmental Laws.
"Environmental Laws" shall mean any Federal, state or local law relating to
releases or threatened releases of Hazardous Substances; the manufacture,
handling, transport, use, treatment, storage or disposal of Hazardous Substances
or materials containing Hazardous Substances; or otherwise relating to pollution
of the environment or the protection of human health. "Hazardous Substances"
shall mean substances or materials which contain substances defined in or
regulated as toxic or hazardous materials, chemicals, substances, waste or
pollutants under any present or future Federal statutes and their state
counterparts, as well as any implementing regulations as amended from time to
time and as interpreted by administering agencies.

            7. DISCLAIMER OF WARRANTIES; LIMITATION OF REMEDY; LIMITATION OF
LIABILITY. Lessee has selected both the Equipment and the supplier (identified
in the Lease Schedule, herein ("Supplier") from whom at Lessee's request Lessor
agrees to purchase the Equipment. LESSEE ACKNOWLEDGES THAT LESSOR HAS NO SPECIAL
FAMILIARITY OR EXPERTISE WITH RESPECT TO THE EQUIPMENT. LESSEE AGREES THAT THE
EQUIPMENT LEASED UNDER THE LEASE IS LEASED "AS IS" AND IS OF A SIZE, DESIGN AND
CAPACITY SELECTED BY LESSEE AND THAT LESSEE IS SATISFIED THAT THE SAME IS
SUITABLE FOR LESSEE'S PURPOSES, AND THAT EXCEPT AS MAY OTHERWISE BE SPECIFICALLY
PROVIDED HEREIN OR IN THE LEASE SCHEDULE, LESSOR HAS MADE NO REPRESENTATION OR
WARRANTY AS TO ANY MATTER WHATSOEVER. LESSOR DISCLAIMS, AND LESSEE HEREBY
EXPRESSLY WAIVES AS TO LESSOR, ALL WARRANTIES WITH RESPECT TO THE EQUIPMENT
INCLUDING BUT NOT LIMITED TO ALL EXPRESS OR IMPLIED WARRANTIES OF
MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE, QUALITY, CAPACITY, OR
WORKMANSHIP, ALL EXPRESS OR IMPLIED WARRANTIES AGAINST PATENT INFRINGEMENTS OR
DEFECTS, WHETHER HIDDEN OR APPARENT, AND ALL EXPRESS OR IMPLIED WARRANTIES WITH
RESPECT TO COMPLIANCE OF THE EQUIPMENT WITH THE REQUIREMENTS OF ANY LAW,
REGULATION, SPECIFICATION OR CONTRACT RELATIVE THERETO. IN NO EVENT SHALL LESSOR
BE LIABLE (INCLUDING WITHOUT LIMITATION, UNDER ANY THEORY IN TORTS) FOR ANY LOSS
OF USE, REVENUE, ANTICIPATED PROFITS OR SPECIAL, INDIRECT, INCIDENTAL OR
CONSEQUENTIAL DAMAGES ARISING OUT OF OR IN CONNECTION WITH THE LEASE OR THE USE,
PERFORMANCE OR MAINTENANCE OF THE EQUIPMENT. If the Equipment is not properly
installed, does not operate as represented or warranted by the Supplier,
manufacturer and/or service company or is unsatisfactory for any reason, Lessee
shall make any claim on account thereof solely against the Supplier,
manufacturer and/or service company and shall, nevertheless, pay Lessor all
amounts payable under the Lease and any such claims shall not act as a defense,
counterclaim, deduction, setoff or otherwise limit Lessee's Obligations under
the Lease. For the Lease Term, for so long as no Default (as hereinafter
defined) has occurred and is continuing, Lessor assigns to Lessee (to the extent
permitted by law) any


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right Lessor may have against the Supplier (under a "Supply Contract", as
defined in the Lease Schedule), manufacturer and/or service company to enforce,
at Lessee's expense (if any), any product warranties with respect to the
Equipment, provided however, Lessee shall indemnify and defend Lessor from and
against all claims, expenses, damages, losses and liabilities incurred or
suffered by Lessor in connection with any such action taken. TO THE EXTENT
PERMITTED BY LAW, LESSEE HEREBY WAIVES ANY AND ALL RIGHTS AND REMEDIES LESSEE
MAY HAVE UNDER ARTICLE 2A OF THE UNIFORM COMMERCIAL CODE.

            8. RISK OF LOSS AND DAMAGE; INSURANCE. Lessee assumes all risk of
loss, damage or destruction to the Equipment from whatever cause and for
whatever reason. If all or a portion of an item of Equipment shall become lost
stolen, destroyed, damaged beyond repair or rendered permanently unfit for use
for any reason, or in the event of any condemnation, confiscation, theft or
seizure or requisition of title to or use of such item of Equipment, Lessee
shall immediately pay to Lessor, in addition to unpaid rent, late charges and
additional rent then past due, an amount equal to the remaining periodic
installments and all other sums due under the Lease, discounted to present value
at the rate of six percent (6%) per annum, less the net amount of the recovery,
if any, received by Lessor from insurance on the Equipment. During the Lease
Term and until the Equipment has been either (i) purchased by Lessee or
(ii) returned to, and accepted by, Lessor in the condition required by the Lease
Schedule, Lessee shall procure and maintain insurance in such amounts and with
such coverages, and upon such terms and with such companies, as Lessor may
approve, at Lessee's expense; provided, however, that in no event shall such
insurance be less than the following coverages and amounts: (a) Worker's
Compensation and Employer's Liability Insurance, in the full statutory amounts
provided by law; (b) Comprehensive General Liability Insurance including
product/completed operations and contractual liability coverage, with minimum
limits on a per occurrence basis, as reasonably required by Lessor, and Combined
Single Limit Bodily Injury and Property Damage on an aggregate basis as
reasonably required by Lessor, or, in either case, as otherwise specified in any
Lease Schedule hereto; and (c) All Risk Physical Damage Insurance, including
earthquake and flood, on each item of Equipment, in an amount equal to the
remaining periodic installments due under the Lease, discounted to present value
at the rate of six percent (6%) per annum; or its full replacement value. Lessor
will be included as an additional insured on each such Comprehensive General
Liability Insurance policy. On each such All Risk Physical Damage Insurance
policy Lessor shall be named as loss payee. Such policies shall be endorsed to
provide that the coverage afforded to Lessor shall not be rescinded, impaired or
invalidated by any act or neglect of Lessee. Lessee agrees to waive Lessee's
rights and its insurance carrier's rights of subrogation against Lessor for any
and all loss or damage. In addition to the foregoing minimum insurance coverage,
Lessee shall procure and maintain such other insurance coverage as Lessor may
reasonably require. All policies shall be endorsed or contain a clause requiring
the insurer to furnish Lessor with at least 30 days prior written notice of any
material change, cancellation or non-renewal of coverage. Upon execution of the
Lease, and thereafter, 30 days prior to the expiration of each insurance policy
required hereunder, Lessee shall furnish Lessor with a certificate of insurance
or other evidence satisfactory to Lessor that the insurance coverages required
under such policy are and will continue in effect, provided, however, that
Lessor shall be under no duty either to ascertain the existence of or to examine
such insurance coverage or to advise Lessee in the event such insurance coverage
should not comply with the requirements hereof. If Lessee shall at any time or
times hereafter fail to obtain and/or maintain any of the policies of insurance
required herein, or fail to pay any premium in whole or in part relating to any
such policies, Lessor may, but shall not be obligated to, obtain and/or cause to
be maintained insurance coverage with respect to the Equipment, including, at
Lessor's option, the coverage provided by all or any of the policies of Lessee
and pay all or any part of the premium therefor, without waiving any Event of
Default by Lessee, and any sums so disbursed by Lessor shall be additional
Obligations of Lessee to Lessor payable on demand. Lessor shall have the right
to settle and compromise any and all claims under any of the All Risk Physical
Damage policies required to be maintained by Lessee hereunder and Lessee hereby
appoints Lessor as its attorney-in--fact, with power to demand, receive and
receipt for all monies payable thereunder, to execute in the name of Lessee or
Lessor or both any proof of loss, notice, draft or other instruments in
connection with such policies or any loss thereunder and generally to do and
perform any and all acts as Lessee, but for this appointment, might or could
perform.

            9. TAXES AND OTHER CHARGES. Lessee agrees to comply with all laws,
regulations and governmental orders related to the Lease and to the manufacture,
purchase, ownership, maintenance, modification, delivery, installation,
possession, condition, use, acceptance, rejection, operation or return of the
Equipment and to pay when due, and to defend and indemnify and hold Lessor
harmless from and against any and all claims, losses, damages, penalties,
actions, suits and liabilities resulting from license fees, assessments, and
sales, use, property, excise, privilege and other taxes (including any related
interest or penalties) or other charges or fees now or hereafter imposed by any
governmental body or agency upon any Equipment, or with respect to the
manufacturing, ordering, shipment, purchase, ownership, delivery, installation,
leasing, operation, possession, use, return, or other disposition thereof or the
rentals hereunder (other than taxes on or measured solely by the net income of
Lessor). In no event shall Lessor have any obligation to advise, submit bills or
any advice or


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material to Lessee with respect to any tax on or relating to the Equipment or
its manufacturing, ordering, shipment, purchase, ownership, delivery,
installation, leasing, operation, possession, use, return, or other disposition
thereof or the rentals hereunder. If local law does not permit direct payment by
Lessee of any of the foregoing and/or if Lessor is required to file a report or
return, Lessee will timely advise Lessor as to its inability under local law to
make direct payment and the amount thereof and/or furnish Lessor with such
forms, data and information as will enable it to make and file such report or
return. Lessee shall promptly furnish to Lessor written evidence of Lessee's
payment of the foregoing when due, or, at Lessor's request, remit such payments
to Lessor. If any of the foregoing shall be paid by Lessor, Lessee shall
reimburse Lessor therefor promptly upon demand as additional rent hereunder.

            10. EVENTS OF DEFAULT. An "Event of Default" under the Lease shall
be deemed to have occurred upon the occurrence or existence of any one or more
of the following events or conditions (each a "Default") and after the giving of
any required notice or the passage of any required period of time (or both)
specified below with respect to such Default: (a) Lessee shall fail to make any
payment due in respect of any Lease within 5 days of its due date; or (b) Lessee
shall fail to obtain or maintain any of the insurance required under the Lease;
or (c) Lessee shall remove, sell, transfer, encumber, or part with possession of
any Equipment; or (d) Lessee shall fail to perform or observe any other
covenant, condition or agreement under the Lease, and such failure shall
continue for 20 days after notice thereof to Lessee; or (e) Lessee or any of its
Affiliates shall default in the payment or performance of any Obligation owing
to Lessor, and such default shall continue for 20 days after notice thereof to
Lessee; or (f) any representation or warranty made by Lessee herein or in any
certificate, agreement, statement or document heretofore or hereafter furnished
Lessor, including without limitation any financial information disclosed to
Lessor, shall prove to be false or incorrect in any material respect; or (g)
death or judicial declaration of incompetence of Lessee, if an individual; or
(h) the commencement of any bankruptcy, insolvency, arrangement, reorganization,
receivership, liquidation or other similar proceeding by or against Lessee or
any of its properties or businesses, or the appointment of a trustee, receiver,
liquidator or custodian for Lessee or any of its properties or businesses, or if
Lessee suffers the entry of an order for relief under Title 11 of the United
States Code; or (i) the making by Lessee of a general assignment or deed of
trust for the benefit of creditors; or (j) Lessee shall default in any payment
or other material obligation to any other lender and such lender has accelerated
the debt in accordance with its terms; or (k) Lessee shall merge with or
consolidate into any other entity or sell all or substantially all of its assets
or in any manner terminate its existence; or (l) if Lessee is a privately held
corporation, more than 50% of Lessee's voting capital stock, or effective
control of Lessee's voting capital stock, issued and outstanding from time to
time, is not retained by the holders of such stock on the date the Lease is
executed, unless, however, Lessor shall have given prior written consent with
respect thereto, which consent will not be unreasonably withheld; or (m) if
Lessee is a publicly held corporation, there shall be a change in the ownership
of Lessee's stock such that Lessee is no longer subject to the reporting
requirements of the Securities Exchange Act of 1934 or no longer has a class of
equity securities registered under Section 12 of the Securities Act of 1933; or
(n) Lessor shall determine that there has been a material adverse change in the
financial condition or business operations of Lessee since the date of execution
of the Lease, or that Lessee's ability to perform its Obligations is materially
impaired; or (o) if Lessee leases the premises where any Equipment is located, a
breach by Lessee of any such lease and the commencement of an action by the
landlord to evict Lessee or to repossess the premises; or (p) any event or
condition set forth in subsections (e) through (o) of this Section 10 shall
occur with respect to any guarantor or other person liable or responsible, in
whole or in part, for payment or performance of any Obligations; or (q) any
event or condition set forth in subsections (e) through (o) shall occur with
respect to any Affiliate of Lessee. Lessee shall promptly notify Lessor of the
occurrence of any Event of Default or the occurrence or existence of any event
or condition which, upon the giving of notice or lapse of time, or both, would
constitute an Event of Default.

            11. RIGHTS AND REMEDIES; ACCELERATION. Upon the occurrence of an
Event of Default, Lessor shall have all of the rights and remedies enumerated
herein (all of which are cumulative and not exclusive of any other right or
remedy available to Lessor) and Lessor may, at its sole option and discretion,
exercise one or more of the following remedies with respect to any or all of the
Collateral (i) by written notice to Lessee, terminate any or all Leases, as such
notice shall specify, and, with respect to such terminated Leases, declare
immediately due and payable and recover from Lessee, as liquidated damages for
loss of Lessor's bargain and not as a penalty, an amount equal to the aggregate
of all unpaid periodic installment payments and other sums due under the Leases
to the date of default plus the charges set forth in Section 4 hereof, if any,
plus the remaining periodic installments and other sums due under the Leases,
discounted to present value at the rate of six percent (6%) per annum; (ii)
Lessor may declare at its option, all or any part of the Obligations immediately
due and payable, without demand, notice of intention to accelerate, notice of
acceleration, notice of nonpayment, presentment, protest, notice of dishonor, or
any other notice whatsoever, all of which are hereby waived by Lessee and any
endorser, guarantor, surety or other party liable in any capacity for any of the
Obligations; (iii) cause Lessee to promptly ship, with insurance and freight
prepaid by Lessee, any or all Equipment to such location as Lessor may designate
in accordance with the terms of Lease Schedules, or


                                     Page 7                      Initial JP / KR
                                                                         -------
<PAGE>

Lessor, at its option, may enter upon the premises where the Equipment is
located and take immediate possession of and remove the same by summary
proceedings or otherwise, all without liability to Lessor for or by reason of
damage to property or such entry or taking possession except for Lessor's gross
negligence or willful misconduct; (iv) sell any or all Equipment at public or
private sale or otherwise dispose of, hold, use, operate, lease to others or
keep idle the Equipment, all as Lessor in its sole discretion may determine and
all free and clear of any rights of Lessee; (v) remedy such default, including
making repairs or modifications to the Equipment, for the account and expense of
Lessee, and Lessee agrees to reimburse Lessor for all of Lessor's costs and
expenses; (vi) apply any Security Deposit or other cash collateral or sale or
remarketing proceeds of the Equipment at any time to reduce any amounts due to
Lessor, (vii) exercise any other right or remedy which may be available to
Lessor under applicable law, or proceed by appropriate court action to enforce
the terms hereof or to recover damages for the breach hereof, including
Attorneys' Fees and Expenses. Any notice required to be given by Lessor of a
sale or other disposition or other intended action which is made in accordance
with the terms of the Lease at least seven (7) days prior to such proposed
action, shall constitute fair and reasonable notice to Lessee of any such
action. Lender shall be liable to Lessor only for its gross negligence or
willful misconduct in failing to comply with any applicable law imposing duties
upon Lessor; Lessor's liability for any such failure shall be limited to the
actual loss suffered by Lessee directly resulting from such failure; and in no
event shall Lessor have any liability to Lessee for incidental, consequential,
punitive or exemplary damages. No remedy referred to in this Section 11 shall be
exclusive, but each shall be cumulative and in addition to any other remedy
referred to above or otherwise available to Lessor at law or in equity.

            (b) The exercise or pursuit by Lessor of any one or more of such
remedies shall not preclude the simultaneous or later exercise or pursuit by
Lessor of any or all such other remedies, and all remedies hereunder shall
survive termination of the Lease. In the event Lessor takes possession and
disposes of the Collateral, the proceeds of any such disposition shall be
applied in the following order: (1) to all of Lessor's costs, charges and
expenses incurred in taking, removing, holding, repairing and selling or leasing
the Equipment; (2) to pay the Lessor the remaining amount of any Obligations
owed to Lessor and (3) the balance, if any, to Lessee. A termination shall occur
only upon written notice by Lessor and only with respect to such Equipment as
Lessor shall specify in such notice. Termination under this Section 11 shall not
affect Lessee's duty to perform Lessee's Obligations under the Lease in full.
Lessee agrees to reimburse Lessor on demand for any and all costs and expenses
incurred by Lessor in enforcing its rights and remedies hereunder following the
occurrence of an Event of Default, including, without limitation, Attorneys'
Fees and Expenses, and the costs of repossession, storage, insuring, reletting,
selling and disposing of any and all Equipment.

            12. RETURN OF EQUIPMENT; EXTENSION OF TERM. Upon demand of Lessor
pursuant to Section II hereof, or unless Lessee purchases the Equipment pursuant
to the Option to Purchase contained in the Lease Schedule, Lessee, at its own
risk and expense, shall immediately return the Equipment to Lessor in accordance
with the Lease Schedule. Should Lessee fail to provide timely notice of exercise
of the Option to Purchase as provided in the Lease Schedule or return the
Equipment to Lessor in the time and manner provided in the Lease Schedule, the
Lease Term shall be extended for successive 30 day periods until Lessee returns
the Equipment to Lessor in accordance with the Lease Schedule, or Lessor
terminates the Lease by 10 days written notice to Lessee. In the event any Lease
is extended pursuant to the preceding sentence, the Rental Payments in effect
prior to the expiration of the Lease Term, and all other provisions of the
Lease, shall continue to apply.

            13. INDEMNITY. (a) Lessee agrees to indemnify, reimburse and hold
Lessor and its successors, Affiliates, assigns, officers, directors, employees,
agents and servants (hereinafter in this Section 13 referred to individually as
"Indemnitee', and collectively as "Indemnitees") harmless from any and all
liabilities, obligations, damages, injuries, penalties, claims, demands,
actions, suits, judgments and any and all costs, expenses or disbursements,
including Attorneys' Fees and Expenses, of whatsoever kind and nature imposed
on, asserted against or incurred by any of the Indemnitees in any way relating
to or arising out of the Lease or any other document executed in connection
herewith or therewith or in any other way connected with the administration of
the transactions contemplated hereby or thereby or the enforcement of any of the
terms of, or the preservation of any rights under any thereof, or in any way
relating to or arising out of the manufacture, ownership, ordering, purchase,
delivery, control, acceptance, lease, financing, possession, operation,
condition, sale, return or other disposition, or use of the Equipment
(including, without limitation, latent or other defects, whether or not
discoverable), the violation of the laws of any country, state or other
governmental body or unit, any tort (including, without limitation, claims
arising or imposed under the doctrine of strict liability, or for or on account
of injury to or the death of any Person (including any Indemnitee), or property
damage), or contract claim, or any claim based on license, patent, trademark or
copyright infringement, or any obligation or liability to the manufacturer or
Supplier of the Equipment arising under any Supply Contracts, including purchase
orders issued by Lessee or Lessor or assigned to Lessor; provided, however that
no Indemnitee


                                     Page 8                      Initial JP / KR
                                                                         -------
<PAGE>

shall be indemnified pursuant to this Section 13 for losses, damages or
liabilities caused solely by the gross negligence or willful misconduct of such
Indemnitee. Lessee agrees that upon written notice by any Indemnitee of the
assertion of such a liability, obligation, damage, injury, penalty, claim,
demand, action, suit or judgment, Lessee shall assume full responsibility for
the defense thereof. Each Indemnitee agrees to use its best efforts to promptly
notify Lessee of any such assertion of which such Indemnitee has knowledge.

            (b) Without limiting the application of Section 13(a) hereof, Lessee
agrees to pay, or reimburse Lessor for any, and all reasonable fees, costs and
expenses (including Attorneys Fees and Expenses) of whatever kind or nature
incurred in connection with the creation, preservation or protection of Lessor's
liens on, and security interest in, the Collateral, including, without
limitation, all fees and taxes in connection with the recording or filing of
instruments and documents in public offices, payment or discharge of any taxes
or liens upon or in respect of the Collateral, premiums for insurance with
respect to the Collateral and all other fees, costs and expenses in connection
with protecting, maintaining or preserving the Collateral and Lessor's interest
therein, whether through judicial proceedings or otherwise, or in defending or
prosecuting any actions, suits or proceedings arising out of or relating to the
Collateral.

            (c) Lessee shall, at its sole cost and expense, protect, defend,
indemnify, release and hold harmless the Indemnitees from and against any and
all Losses imposed upon or incurred by or asserted against any Indemnitees, and
arising out of or in any way relating to any one or more of the following,
unless caused solely by the gross negligence or willful misconduct of any
Indemnitee: (i) any presence of any Hazardous Substances in, on, above or under
Lessee's leased or owned real property (the "Property"); (ii) any past, present
or threatened Release of Hazardous Substances in, on, above, under or from the
Property; (iii) any past or present violation of any Environmental Laws. The
term "Release" of any Hazardous Substance includes, but is not limited to, any
release, deposit, discharge, emission, leaking, spilling, seeping, migrating,
injecting, pumping, pouring, emptying, escaping, dumping, disposing or other
movement of Hazardous Substances. The term "Losses" includes any and all claims,
suits, liabilities (including, without limitation, strict liabilities), actions,
proceedings, obligations, debts, damages, losses, costs, expenses, diminution's
in value, fines, penalties, charges, fees, expenses, judgments, awards, amounts
paid in settlement, costs of remediating a Hazardous Substance (whether or not
performed voluntarily), engineers' fees, environmental consultants' fees, and
costs of investigation (including, but not limited to sampling, testing and
analysis of soil, water, air, building materials and other materials and
substances whether solid, liquid or gas) or punitive damages, of whatever kind
or nature (including, but not limited to Attorneys' Fees and Expenses).

            (d) Without limiting the application of Section 13(a), (b) or (c)
hereof, Lessee agrees to pay, indemnify and hold each Indemnitee harmless from
and against any loss, costs, damages and expenses (including Attorneys' Fees and
Expenses) which such Indemnitee may suffer, expend or incur in consequence of or
growing out of any misrepresentation or omission of a material fact by Lessee in
the Lease or in any writing contemplated by or made or delivered pursuant to or
in connection with the Lease.

            (e) If and to the extent that the obligations of Lessee under this
Section 13 are unenforceable for any reason, Lessee hereby agrees to make the
maximum contribution to the payment and satisfaction of such obligations which
is permissible under applicable law.

            14. MAINTENANCE; INSPECTION. During the Lease Term for each item of
Equipment, Lessee shall, unless Lessor shall otherwise consent in writing:(a)
maintain conspicuously on any Equipment such labels, plates, decals or other
markings as Lessor may reasonably require, stating that Lessor is owner of such
Equipment; (b) furnish to Lessor such information concerning the condition,
location, use and operation of the Equipment as Lessor may request; (c) permit
any person designated by Lessor to visit and inspect any Equipment and any
records maintained in connection therewith, provided, however, that the failure
of Lessor to inspect the Equipment or to inform Lessee of any noncompliance
shall not relieve Lessee of any of its obligations hereunder; and (d) make no
additions, alterations, modifications or improvements (collectively,
"Improvements") to any item of Equipment that are not readily removable without
causing material damage to such item of Equipment or which will cause the value,
utility or useful life of such item of Equipment to materially decline. If any
such Improvement is made and cannot be removed without causing material damage
or decline in value, utility or useful life (a "Non-Severable Improvement" ),
then Lessee warrants that such Non-Severable Improvement shall immediately
become Lessor's property upon being installed and shall be free and clear of all
liens and encumbrances and shall become Equipment subject to all of the terms
and conditions of the Lease. All such Improvements that are not Non-Severable
Improvements shall be removed by Lessee prior to the return of the item of
Equipment hereunder or such Improvements shall also become the sole and absolute
property of Lessor without any further payment by Lessor to Lessee and shall be
free and clear of all liens and


                                     Page 9                      Initial JP / KR
                                                                         -------
<PAGE>

encumbrances whatsoever. Lessee shall repair all damage to any item of Equipment
caused by the removal of any Improvement so as to restore such item of Equipment
to the same condition which existed prior to its installation and as required by
the Lease.

            15. FURTHER ASSURANCES. Lessee shall promptly execute and deliver to
Lessor such further documents and take such further action as Lessor may require
in order to more effectively carry out the intent and purpose of the Lease.
Lessee shall execute and deliver to Lessor upon Lessor's request any and all
schedules, forms and other reports and information as Lessor may deem necessary
or appropriate to respond to requirements or regulations imposed by any
governmental authorities or to comply with the provisions of the law of any
jurisdiction in which Lessee may then be conducting business or in which any of
the Equipment may be located. Lessee shall execute and deliver to Lessor upon
Lessor's request such further and additional documents, instruments and
assurances as Lessor deems necessary to acknowledge and confirm, for the benefit
of Lessor or any assignee or transferee of any of Lessor's rights, title and
interests hereunder in accordance with Section 16 hereof (an "Assignee"), all of
the terms and conditions of all or any part of the Lease and Lessor's or
Assignee's rights with respect thereto, and Lessee's compliance with all of the
terms and provisions thereof.

            16. ASSIGNMENT. The provisions of the Lease shall be binding upon
and shall inure to the benefit of the heirs, administrators, successors and
assigns of Lessor and Lessee, provided, however, Lessee may not assign any of
its rights, sublease Equipment or delegate any of its obligations under the
Lease without the prior written consent of Lessor in its sole discretion. Lessor
may, from time to time, absolutely or as security, without notice to Lessee,
sell, assign, transfer, participate, pledge or otherwise dispose of all or any
part of a Lease, the Obligations and/or the Collateral therefor, subject to the
rights of Lessee under the Lease for the use and possession of the Equipment. In
such event, each and every immediate and successive Assignee shall have the
right to enforce the Lease with respect to those Obligations and/or Collateral
transferred to the Assignee, by legal action or otherwise, for its own benefit
as fully as if such Assignee were herein by name specifically given such rights.
Lessee agrees that the rights of any such Assignee hereunder or with respect to
the related Obligations, shall not be subject to any defense, set off or
counterclaim that Lessee may assert or claim against Lessor, and that any such
Assignee shall have all of Lessor's rights hereunder but none of Lessor's
obligations. Lessor shall have an unimpaired right to enforce the Lease for its
benefit with respect to that portion of any Lease, Obligations and/or Collateral
that Lessor has not sold, assigned, pledged or otherwise transferred.

            17. GOVERNING LAW; MEDIATION OF THE LEASE. THE LEASE AND THE LEGAL
RELATIONS OF THE PARTIES HERETO SHALL IN ALL RESPECTS BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF CONNECTICUT, WITHOUT
REGARD TO PRINCIPLES REGARDING THE CHOICE OF LAW. LESSEE HEREBY CONSENTS AND
SUBMITS TO THE NON-EXCLUSIVE JURISDICTION OF THE COURTS OF THE STATE OF
CONNECTICUT AND THE FEDERAL DISTRICT COURT FOR THE DISTRICT OF CONNECTICUT FOR
THE PURPOSES OF ANY SUIT, ACTION OR OTHER PROCEEDING ARISING OUT OF ITS
OBLIGATIONS UNDER THE LEASE, AND EXPRESSLY WAIVES ANY OBJECTIONS THAT IT MAY
HAVE TO THE VENUE OF SUCH COURTS. LESSEE HEREBY EXPRESSLY WAVES ANY RIGHT TO
TRIAL BY JURY IN ANY ACTION BROUGHT ON OR WITH RESPECT TO THE LEASE. Any action
by Lessee against Lessor for any cause of action under the Lease shall be
brought within one year after any such cause of action first arises. If
requested by Lessor, Lessee agrees that prior to the commencement of any
litigation regarding the terms and conditions of the Lease, the parties hereto
shall subject themselves to non-binding mediation with a qualified mediator
mutually satisfactory to both parties.

            18. NOTICES. Any demand or notice required or permitted to be given
hereunder shall be deemed effective (a) when deposited in the United States
mail, and sent by certified mail, return receipt requested, postage prepaid,
addressed to Lessor or to Lessee at the addresses set forth herein, or to such
other address as may be hereafter provided by the party to be notified by
written notice complying with the provisions hereof or (b) when transmitted to
Lessor or Lessee by facsimile at the respective numbers provided for such
purpose; provided, that such facsimile notice is promptly followed by notice
given in accordance with the immediately preceding subsection (a).

            19. SECURITY DEPOSIT. Lessor may, at its option, apply the Security
Deposit, if any is indicated in a Lease Schedule, to cure any default of Lessee,
whereupon Lessee shall promptly restore such Security Deposit to its original
amount. Lessor shall return to Lessee any unapplied Security Deposit, without
interest, upon full payment and performance of Lessee's Obligations under the
Lease.


                                    Page 10                      Initial JP / KR
                                                                         -------
<PAGE>

            20. MISCELLANEOUS; GENERAL PROVISIONS. The Lease will not be binding
on Lessor until accepted and executed by Lessor at its executive office in South
Norwalk, Connecticut. All options, powers and rights granted to Lessor hereunder
or under any promissory note, guaranty, letter of credit agreement, depository
agreement, instrument, document or other writing delivered to Lessor shall be
cumulative and shall be in addition to any other options, powers or rights which
Lessor may now or hereafter have under any applicable law or otherwise. Time is
of the essence in the payment and performance of all of Lessee's obligations
under the Lease. The captions in the Lease are for convenience only and shall
not define or limit any of the terms thereof.

            Any provisions of this Lease which are unenforceable in any
jurisdiction shall, as to such jurisdiction, be ineffective to the extent of
such unenforceability without invalidating the remaining provisions hereof, and
any such unenforceability in any jurisdiction shall not render unenforceable
such provisions in any other jurisdiction. To the extent permitted by applicable
law, Lessee hereby waives any provisions of law which render any provision of
the Lease unenforceable in any respect.

            LESSEE ACKNOWLEDGES THAT THE TRANSACTION OF WHICH THIS AGREEMENT IS
A PART IS A COMMERCIAL TRANSACTION AND EXCEPT AS OTHERWISE PROVIDED IN THE
LEASE, LESSEE HEREBY WAIVES, TO THE EXTENT PERMITTED BY APPLICABLE LAW, NOTICE
AND JUDICIAL HEARING IN CONNECTION WITH LESSOR'S TAKING POSSESSION OR LESSOR'S
DISPOSITION OF ANY OF THE COLLATERAL, INCLUDING, WITHOUT LIMITATION, ANY AND ALL
PRIOR NOTICE AND HEARING FOR ANY PREJUDGMENT REMEDY OR REMEDIES AND ANY SUCH
RIGHT WHICH LESSEE WOULD OTHERWISE HAVE UNDER THE CONSTITUTION OR ANY STATUTE OF
THE UNITED STATES OR OF ANY STATE, INCLUDING, WITHOUT LIMITATION, ITS RIGHTS TO
NOTICE AND HEARING UNDER CHAPTER 903A OF THE CONNECTICUT GENERAL STATUTES.

            THE LEASE AND ANY OTHER WRITTEN AGREEMENT(S) BETWEEN THE PARTIES
EXECUTED SIMULTANEOUSLY HEREWITH, REPRESENT THE FINAL AGREEMENT BETWEEN THE
PARTIES CONCERNING THE SUBJECT MATTER HEREOF, AND SUPERSEDE AND MAY NOT BE
CONTRADICTED BY ANY PRIOR WRITTEN AGREEMENTS BETWEEN THE PARTIES, INCLUDING,
WITHOUT LIMITATION, PROPOSALS, LETTERS, COMMITMENT LETTERS OR BY ANY PRIOR,
CONTEMPORANEOUS OR SUBSEQUENT ORAL AGREEMENTS BETWEEN THE PARTIES. LESSEE
ACKNOWLEDGES AND CERTIFIES THAT NO SUCH ORAL AGREEMENTS EXIST. THE LEASE MAY NOT
BE AMENDED, NOR MAY ANY RIGHTS UNDER THE LEASE BE WAIVED, EXCEPT BY AN
INSTRUMENT IN WRITING SIGNED BY THE PARTY AGAINST WHOM SUCH AGREEMENT OR WAIVER
IS ASSERTED. The failure of Lessor at any time or times hereafter to require
strict performance by Lessee of any of the provisions, warranties, terms and
conditions contained in the Lease or in any other agreement, guaranty, note,
depository agreement, letter of credit instrument or document now or at any time
or times hereafter executed by Lessee or an Affiliate of Lessee and delivered to
Lessor shall not waive, affect or diminish any right of Lessor at any time or
times hereafter to demand strict performance thereof. The Lease may be executed
in any number of counterparts, each of which shall be deemed to be an original,
but all of which together shall constitute but one and the same instrument. The
section headings herein are included for convenience only and shall not be
deemed to be a part of the Lease. Each reference herein to "Lessor" shall be
deemed to include its successors and assigns, and each reference to "Lessee" and
any pronouns referring thereto as used herein shall be construed in the
masculine, feminine, neuter, singular or plural, as the context may require, and
shall be deemed to include the legal representatives, successors and assigns of
Lessee, all of whom shall be bound by the provisions hereof. EACH REFERENCE
HEREIN TO "LESSEE" SHALL MEAN AND INCLUDE ANY AND ALL LESSEES WHO SIGN BELOW,
EACH OF WHOM SHALL BE JOINTLY AND SEVERALLY LIABLE UNDER THE LEASE.

            The Lease, and all related documents, including (a) amendments,
addenda, consents, waivers and modifications which may be executed
contemporaneously or subsequently herewith, (b) documents received by Lessor
from the Lessee, and (c) financial statements, certificates and other
information previously or subsequently furnished to Lessor, may be reproduced by
Lessor by any photographic, photostatic, microfilm, micro-card, miniature
photographic, compact disk reproduction or other similar process and Lessor may
destroy any original document so reproduced. Lessee agrees, herein waives all
right to object to the admissibility of such reproduction and stipulates that
any such reproduction shall, to the extent permitted by law, be admissible in
evidence as the original itself in any judicial or administrative proceeding
(whether or not the original itself is in existence and whether or not the
reproduction was made by Lessor in the regular course of business) and that any
enlargement, facsimile or further reproduction of the reproduction shall
likewise be admissible in evidence.


                                    Page 11                      Initial JP / KR
                                                                         -------
<PAGE>

            21. SURVIVAL. Sections 7, 8, 9, 11, 12, 13, 14, 17, 18, 19 and 20
shall survive and continue in full force and effect without regard to the
payment in full of all Obligations under the Lease.

      Executed and delivered by duly authorized representatives of the parties
hereto as of the date set forth below.

LESSOR:                                     LESSEE:

OXFORD VENTURE FINANCE, LLC                 GENAISSANCE PHARMACEUTICALS, INC.

By:  /s/ J.A. Philbrick                     By:  /s/ Kevin Rakin
   ----------------------------                ----------------------------

Name:  J.A. PHILBRICK                       Name:  KEVIN RAKIN
     --------------------------                  --------------------------

Title:  PRESIDENT                           Title:  EVP & CFO
      -------------------------                   -------------------------

Date:  6-10-99                              Date:  6/14/99
     --------------------------                  --------------------------


                                    Page 12                      Initial JP / KR
                                                                         -------
<PAGE>

                                   SCHEDULE 1


Trade Names


                                    Page 13                      Initial JP / KR
                                                                         -------
<PAGE>

                                   SCHEDULE 2

Name Changes; Changes in Chief Executive Office


Lessee is formerly known as BIOS Laboratories, Inc.


                                    Page 14                      Initial JP / KR
                                                                         -------


                      Schedules to be filed by amendment

<PAGE>

                    RATE ADJUSTMENT RIDER AND ACKNOWLEDGMENT

      RATE ADJUSTMENT RIDER AND ACKNOWLEDGMENT (this "Rider") to the Equipment
Lease Schedule No. 01 (the "Lease Schedule") and the related Master Equipment
Lease Agreement No. 7667 dated June 10, 1999 (the "Master Lease" and together
with the Lease Schedule, the "Lease"), between GENAISSANCE PHARMACEUTICALS,
INC., as lessee (the "Lessee") and OXFORD VENTURE FINANCE, LLC, as Lessor
("Oxford"). This Rider is entered into pursuant to and incorporates by this
reference all of the terms and provisions of the Lease. By its execution and
delivery of this Rider, Lessee hereby reaffirms all of the representations,
warranties and covenants contained in the Lease as of the date hereof, and
further represents and warrants to Lessor that no Default has occurred and is
continuing as of the date hereof.

      1. Purpose. This Rider amends and restates the terms of the payments set
forth in Acceptance Certificate.

      2. Definitions. The following terms shall have the following meanings
herein:

      (a) "Adjustment Date" shall mean [the date Oxford disburses any portion of
the proceeds of the Lease][the date Oxford receives Lessee's executed Acceptance
Certificate in Oxford's standard form (following delivery) evidencing Lessee's
acceptance of the Equipment described in the Lease].

      (b) "Final T-Note Average" shall mean the average of the yields on U.S.
Treasury Notes maturing in 3 years, as published by the Dow Jones Telerate
Access Service, Page 19901, for the close of business on each business day of
the two full calendar weeks immediately preceding the week containing the
Adjustment Date.

      (c) "Preliminary Payments" shall mean the payments set forth in the Lease
Schedule, consisting of $15,548.99 due upon execution (the "Advance Payment")
followed by 47 consecutive monthly payments.

      (d) "Preliminary T-Note Average" shall mean 5.01%.

      3. Adjustment of Payments. The Preliminary Payments were calculated based
on a spread over the Preliminary T-Note Average. Should the Final T-Note Average
differ from the Preliminary T-Note Average, then the Preliminary Payments shall
be revised. For each increase or decrease of one (1) basis point (i.e., 1/100 of
1%) in the Final T-Note Average above or below the Preliminary T-Note Average,
the Preliminary Payments shall be revised as follows (complete below as
applicable):

      The Advance Payment, due upon execution of the Equipment Schedule, shall
remain unchanged.

      Each of the monthly payments initially scheduled, in the amount of
$15,548.99, shall increase or decrease by $2.87.

      THE CALCULATION OF THE CONTRACT PAYMENTS UNDER THIS RIDER WILL SUPERSEDE
ANY PRIOR PROPOSAL OR QUOTATION. LESSEE HEREBY ACKNOWLEDGES AND AGREES TO THE
CALCULATION OF THE PAYMENT SCHEDULE SET FORTH HEREIN.
<PAGE>

      4. Oxford's Requirements. The commencement of the Lease is subject to
satisfaction of all documentation and credit requirements of Oxford. If such
requirements are not satisfied by the Adjustment Date, then Oxford may, at its
sole option, declare that the Adjustment Date shall be the date when such
requirements are satisfied.

Dated as of: June 10, 1999

OXFORD VENTURE FINANCE, LLC               GENAISSANCE PHARMACEUTICALS, INC.


By: /s/ J.A. Philbrick                    By: /s/ Kevin Rakin
   ----------------------------              ----------------------------

Name: J.A. PHILBRICK                      Name: KEVIN RAKIN
     --------------------------                --------------------------

Title: PRESIDENT                          Title: EVP & CFO
      -------------------------                 -------------------------


<PAGE>


                              COLLATERAL MIX RIDER

                                       TO

                    MASTER EQUIPMENT LEASE AGREEMENT NO. 7667

                               DATED JUNE 10, 1999

                                     BETWEEN

                   OXFORD VENTURE FINANCE, LLC (the "LESSOR")

                                       AND

                GENAISSANCE PHARMACEUTICALS, INC. (the "LESSEE")

Lessee, GENAISSANCE PHARMACEUTICALS, INC., on or before December 31, 1999, shall
cause the composition and mix of Equipment to conform to and meet the following
concentration requirements (hereinafter "Concentration Requirement") for each
class of Equipment (hereinafter "Equipment Class") as identified and set forth
below. Lessee GENAISSANCE PHARMACEUTICALS. INC., herein represents and warrants
that it shall maintain each such Equipment Class and its respective
Concentration Requirement from and after such above referenced date and
continuing thereafter to the end of the term:

<TABLE>
<CAPTION>

         EQUIPMENT CLASS            CONCENTRATION REQUIREMENT
         ---------------            -------------------------
         <S>                            <C>
         Laboratory Equipment           Minimum of 100%

         Manufacturing Equipment        Minimum of 0%

         Computer Equipment             Minimum of 0%

         Furniture                      Minimum of 0%

         Other (telephone, etc.)        Minimum of 0%

         Leasehold Improvements         Maximum of 0%

</TABLE>


<PAGE>


Dated as of: JUNE 10, 1999

         OXFORD VENTURES VENTURE, LLC       GENAISSANCE PHARMACEUTICALS, INC.

         By:                                By:
            --------------------------         ------------------------------


         Name:                              Name:
              ------------------------           ----------------------------


         Title:                             Title:
               -----------------------            ---------------------------


         Date:                              Date:
              ------------------------           ----------------------------


<PAGE>


                             ACCEPTANCE CERTIFICATE


          MASTER EQUIPMENT LEASE AGREEMENT NO. 7667 DATED JUNE 10, 1999

                              LEASE SCHEDULE NO. 01


--------------------------------------------------------------------------------


TO:  OXFORD VENTURE FINANCE, LLC (Lessor)

         The undersigned certifies that all of the Equipment described below and
in the Lease Schedule to the Master Equipment Lease Agreement referred to above
(the "Lease") has been delivered to and inspected by the undersigned; that said
Equipment is in good condition and has been unconditionally accepted by the
undersigned.

         By its execution and delivery of this Acceptance Certificate, Lessee
hereby reaffirms all of the representations, warranties and covenants contained
in the Lease as of the date hereof, and further represents and warrants to
Lessor that no Event of Default, and no event or condition which with notice or
the passage of time or both would constitute an Event of Default, has occurred
and is continuing as of the date hereof. Lessee further certifies to Lessor that
Lessee has selected the Equipment and has received and approved the purchase
order, purchase agreement or supply contract under which the Equipment was
acquired for all purposes of the Lease.

EQUIPMENT DESCRIPTION:


SEE EQUIPMENT EXHIBIT A TO LEASE SCHEDULE NO. 01 AND MADE A PART HEREOF.


<PAGE>


                                  LESSEE NAME:

                                  GENAISSANCE PHARMACEUTICALS, INC.

                                  By:
                                     ------------------------------
                                               Signature


                                  ------------------------------------
                                                 Name


                                  ------------------------------------
                                                Title


                                  ------------------------------------
                                                 Date


<PAGE>


                     TAX ACKNOWLEDGMENT AND INDEMNIFICATION

Oxford Venture Finance, LLC

133 North Fairfax Street

Alexandria, Virginia 22314

         This Tax Acknowledgment and Indemnification ("Acknowledgment") is
attached to and made a part of that certain Lease Schedule No. 01, (the "Lease
Schedule"), to Master Equipment Lease Agreement No. 7667, dated as of June 10,
1999 (the "Lease Agreement"), by and between Oxford Venture Finance, LLC and the
undersigned.

         Notwithstanding any provision to the contrary in the Lease Agreement,
we hereby confirm our " understanding and acknowledgment of the following:

         1. While you normally bill us for taxes, if any, payable on the rentals
(sales/use taxes), you will not bill us for or furnish any advice with respect
to any taxes on the Equipment ("Taxes"), including personal property, ad valorem
or other taxes imposed by any state, federal, local or foreign government in
connection with the purchase, possession, ownership or operation of the
Equipment.

         2. It is our obligation to and we shall timely submit such reports,
declarations, inventories and other documentation, file such returns, and pay
the applicable Taxes when due in connection with the Equipment. If local law
prohibits us from making direct payment or filing the applicable report or
return it our responsibility to and we shall immediately advise you in writing
to such effect and furnish you with the forms, data and information as will
enable you to make and file the return or report, along with our payment for the
Tax due. Any accrual of interest and penalties resulting from our failure to
comply with the foregoing, or otherwise, is and shall be our responsibility.

         3. Upon your request, we shall provide you with copies of satisfactory
documentation and proof of payment of such Taxes. We shall indemnify you and
hold you harmless from and against any such Taxes, and any penalties and
interest thereon, and any other liabilities and damages that you may incur
arising out of our failure to pay when due such Taxes. The indemnity and
covenants set forth herein shall continue in full force and effect and shall
survive the expiration or earlier termination of the Lease Agreement or the
Lease Schedule.

         All capitalized terms used herein and not defined herein shall have the
meanings set forth or referred to in the Lease Schedule. Except as specifically
set forth herein, all of the terms and conditions of the Lease Agreement and the
Lease Schedule shall remain in full force and effect and are hereby ratified and
affirmed. To


<PAGE>


the extent that the provisions of this Acknowledgment conflict with any
provisions contained in the Lease Agreement or the Lease Schedule, the
provisions of this Acknowledgment shall control.


                                  Very truly yours,

                                  LESSEE:

                                  GENAISSANCE PHARMACEUTICALS, INC.

                                  By:
                                     ------------------------------

                                  Title:
                                        ---------------------------

                                  Date:
                                       ----------------------------


<PAGE>


                             SECRETARY'S CERTIFICATE

         I am the duly elected Secretary of GENAISSANCE PHARMACEUTICALS, INC.,
which is a Delaware corporation (the "Corporation"). I certify to OXFORD VENTURE
FINANCE, LLC that:

         4. The following officers of the Corporation have been duly elected (or
appointed), and they are qualified and acting officers of the Corporation. Their
genuine signatures appear below opposite their names:


          OFFICE                NAME                    SIGNATURE

          President          Gualberto Ruano
                                                  ------------------------

          Vice President     Kevin Rakin
                                                  ------------------------

          Secretary          Kevin Rakin
                                                  ------------------------

          Treasurer          Kevin Rakin
                                                  ------------------------


         5. The Corporation is duly organized, validly existing and in good
standing under the laws of the State of Delaware.

         6. Resolutions properly adopted by the Board of Directors of the
Corporation appear below. These resolutions have not been revoked, amended,
modified or supplemented, and they are still in effect as written.

         "WHEREAS, the Board of Directors of the Corporation believes it is in
         the best interests of the Corporation to enter into a Master Equipment
         Lease Agreement with Oxford Venture Finance, LLC ("Oxford");

         RESOLVED, that the Corporation is authorized to lease equipment from
         Oxford, pursuant to the terms of a Master Equipment Lease Agreement and
         all of its exhibits, riders, schedules and attachments (collectively,
         the "Lease"), the terms


<PAGE>


         of which have been reviewed by each of the directors, to be signed and
         delivered by the Corporation, and be it further

         RESOLVED, that the Corporation is authorized to execute and deliver a
         Warrant to Phoenixcor, Inc., which is Oxford's assignee in this
         equipment leasing transaction, entitling the holder to purchase 18,043
         shares of the Corporation's common stock (the "Warrant") upon the terms
         and conditions set forth in the Warrant, and that the Corporation is
         authorized to and does hereby reserve 18,043 shares of its common stock
         (the "Shares") for issuance in connection with the exercise of the
         Warrant.

         NOW, THEREFORE, be it:

         RESOLVED, that the officers of the Corporation are hereby authorized
         and directed to execute and deliver stock certificates to the holder of
         the Warrant or its designee upon the exercise of its rights to acquire
         the Shares under the Warrant.

         RESOLVED, that the President or any Vice President of the Corporation,
         acting alone or together with the Secretary of the Corporation are
         authorized and directed to sign and deliver and perform the Lease and
         the Warrant in the name and on behalf of the Corporation. Any of these
         officers are also authorized to sign and deliver all other documents,
         including, without limitation, filings, financing statements,
         instruments, and certificates, required by Oxford to effect this
         transaction. Any of these officers are also authorized to make any
         changes or add additional terms as may appear in the final Lease,
         Warrant and any such accompanying documents signed by any of these
         officers; and be it further

         RESOLVED, that each officer of the Corporation is authorized and
directed to sign and deliver all other documents and to take all further lawful
actions to implement the previous resolutions."

         7. The Corporation shall furnish written notice to Oxford of any
revocation, modification or amendment of any corporate action affecting any of
the foregoing certifications, and Oxford shall be entitled to rely on these
certifications until such notice is received by Oxford.


<PAGE>


         IN WITNESS WHEREOF, I have hereunto set my hand, this ___ day of June,
1999.



                                  ----------------------------------
                                         Kevin Rakin, Secretary


         The undersigned does hereby certify that he is President of the above
Corporation and does hereby certify that Kevin Rakin was, at the time he
executed the foregoing certificate, a duly elected, qualified and acting
Secretary of the Corporation, and he/she was duly authorized and empowered to do
so, and the is genuine.



                                  ---------------------------------
                                      Gualberto Ruano, President
<PAGE>

                                  LEASE SCHEDULE
                                       TO
                        MASTER EQUIPMENT LEASE AGREEMENT

MASTER EQUIPMENT LEASE AGREEMENT NO. 7667            DATED: JUNE 10, 1999
                                     ----                   -------------
LEASE SCHEDULE NO. 01
                   --


         LESSOR:                               LESSEE:

         OXFORD VENTURE FINANCE, LLC           GENAISSANCE PHARMACEUTICALS, INC.
         133 NORTH FAIRFAX STREET              FIVE SCIENCE PARK
         ALEXANDRIA, VIRGINIA 22314            NEW HAVEN, CT 06511

LESSOR AND LESSEE HAVE ENTERED INTO MASTER EQUIPMENT LEASE AGREEMENT NO. 7667
DATED JUNE 10, 1999 (THE "AGREEMENT") WHICH IS INCORPORATED HEREIN. THIS IS A
LEASE SCHEDULE TO THE AGREEMENT. ALL WORDS AND TERMS USED HEREIN AND NOT
SPECIFICALLY DEFINED HEREIN SHALL HAVE THE SAME MEANINGS AS SET FORTH IN THE

AGREEMENT.

         1. EQUIPMENT LOCATION (if other than above address of Lessee):

         2. EQUIPMENT: The Equipment described in the attached Exhibit A,
incorporated herein by this reference, is leased by Lessor to Lessee on the
terms specified herein and in any addendum or amendment hereto and in the
Agreement.

         3. ACQUISITION COST OF THE EQUIPMENT: $604,290.00

         4. SUPPLIER(S):

         5. LEASE TERM COMMENCEMENT DATE: September 30, 1999.

         6. RENTAL PAYMENTS: Lessee shall pay rent to Lessor for the Equipment,
plus applicable sales/use taxes, payable as follows:

            Advance Rent of $15,548.99 shall be due with the execution of this
Schedule.

The first Rental Payment (together with the interim rent computed as provided in
Section 4 of the Agreement) shall be due thirty (30) days following the Lease
Term Commencement Date.

The remaining Rental Payments shall be due on the same day of each consecutive
payment period thereafter for the duration of the Lease Term, in the amount of
$15,548.99, on each such Rental Payment Date.

         7. LEASE TERM: 48 MONTHS

         8. SECURITY DEPOSIT: none.

         9. DISBURSEMENT OF PROCEEDS. Lessee hereby authorizes Lessor to
disburse the $604,290.00 proceeds as follows:

         (a)      $604,290.00        to:    Perkin Elmer
                  -----------

                  $604,290.00       TOTAL PROCEEDS:
                  -----------
                  -----------

         Lessee may direct the Lessor in writing to withhold payments from
Supplier(s), either now or in the future. Lessor shall be entitled to rely on
such written direction of Lessee as being conclusive as to the intent of the
Lessee with regard to withheld payments.


<PAGE>


         Lessee hereby acknowledges and agrees that it shall constitute an
additional Event of Default under the Lease if, for any reason, the Acquisition
Cost of the Equipment has not been fully paid to the appropriate Supplier(s)
thereof within ten (10) days after demand therefor by Lessor. Lessee hereby
agrees to indemnify, and hold harmless Lessor from and against any liability,
claim, loss or damage, including Attorneys Fees and Expenses that may be
incurred by Lessor as a result of any amounts to be withheld hereunder,
including any claims of the Supplier(s) therefor.

         10. ADJUSTMENTS: Lessee acknowledges that the Rental Payments herein,
are based upon the Acquisition Cost of the Equipment set forth above, and as a
result of authorized changes to the Equipment, the final Acquisition Cost of the
Equipment may increase or decrease by up to 10%. In such event, the Rental
Payments shall be adjusted accordingly, and Lessee authorizes Lessor to correct
the Lease (and all related documentation) to reflect such changes and Lessee, if
requested by Lessor, shall confirm such changes to Lessor in writing.

         11. SUPPLY CONTRACT: Lessee acknowledges either that (a) Lessee has
reviewed and approved any written purchase agreement or purchase order covering
the Equipment ("Supply Contract") purchased from Supplier, or (b) Lessor has
informed or advised Lessee, in writing, either previously or by the Lease, of
the following: (i) the identity of the Supplier, (ii) that Lessee may have
rights under the Supply Contract and (iii) that Lessee may contact the Supplier
for a description of any such rights Lessee may have under the Supply Contract.
If Lessee has entered into a written Supply Contract, then Lessee hereby assigns
to Lessor all of Lessee's rights and interests in and to the Equipment and the
Supply Contract. If requested by Lessor, Lessee shall obtain any consent
required for such assignment. If Lessee has not entered into any such Supply
Contract, Lessee authorizes Lessor to (and Lessor may at its option ) act on
behalf of Lessee to obtain a Supply Contract from Supplier. Except for the
obligation to pay Supplier for the Equipment, if (and only if) the Equipment is
accepted by Lessee under the Lease, such assignment shall not include any of
Lessee's obligations under such Supply Contract and Lessee shall at all times
remain liable to perform all of its duties and obligations under the Supply
Contract to the same extent as if an assignment has not occurred. Lessee hereby
represents and warrants that: (i) Lessee has delivered herewith a true and
correct copy of the Supply Contract, neither Supplier nor Lessee is in default
under the Supply Contract and it shall not be amended without Lessor's prior
written consent and (ii) the Supply Contract is free from all claims, security
interests, liens and encumbrances, except for the interest being conveyed by the
Lease. Lessee indemnifies and holds Lessor harmless with respect to any and all
claims relating to the performance of Lessee's obligations under the Supply
Contract.

         12. PURCHASE OPTION; RETURN OPTION: Lessee shall have the following
options and obligations set forth at the end of the Lease Term:

                  (A) Option to Purchase Equipment. Provided no Event of Default
has occurred and is continuing under the Lease, Lessee shall have the option,
exercisable by written notice to Lessor received by Lessor at least thirty (30)
days before the expiration of the Lease Term to purchase on the day following
the last day of such Lease Term (herein "Purchase Date") all but not less than
all of the Equipment subject to the Lease for a Purchase Option Price of $1.00.
Provided Lessee has exercised its option to purchase, Lessee shall pay to Lessor
on the Purchase Date the aforementioned purchase price in cash, together with
all sales and other taxes or costs applicable to the transfer of the Equipment
and any other amounts as may be due and owing under the Lease, whereupon Lessor
shall transfer its interest in the Equipment to Lessee without recourse, on an
AS-IS, WHERE-IS basis and without any warranty, express or implied from Lessor,
other than the absence of any liens created by or through Lessor, except those
(if any) Lessee is obligated to discharge. In the event that Lessee fails to
exercise such purchase option, Lessee shall (upon termination of the Lease)
return the Equipment to Lessor upon demand, in accordance with the provisions of
the Lease.

                  (B) Option to Return Equipment. Provided no Event of Default
has occurred and is continuing under the Lease, Lessee shall have the option to
return the Equipment at the end of the Lease Term in accordance with the Lease.
Lessee shall give to Lessor written notice of its election to exercise the
return option provided for in this Paragraph at least thirty (30) days prior to
the expiration of the Lease Term. The following terms and conditions shall apply
to the return of the Equipment: (a) subject to the storage/show period described
in (g) below, at the option of Lessor, Lessee shall properly de-install,
dismantle, crate and deliver the Equipment to a location designated by Lessor in
writing within the continental United States by the later of fifteen (15) days
after the end of the Lease Term or thirty (30) days after Lessor gives notice
designating the location for delivery; (b) the Equipment return, including but
not limited to de-installation, dismantling and packing shall be performed or
supervised by the manufacturer's representative and in compliance with the
manufacturer's recommendations; (c) the cost of all items related to the return
of the Equipment, including but not limited to de-installation, dismantling by
manufacturer's representative, removal, assembling, packing, insuring and
transporting the Equipment will be


<PAGE>


at the expense of Lessee; (d) the Equipment shall be shipped by a reputable
carrier (with freight and insurance prepaid) to the location designated by
Lessor and prior to shipment Lessee shall deliver to Lessor a certificate
evidencing that transit insurance is in place from the place of shipment to the
place of destination and naming Lessor as loss payee for the replacement cost of
the Equipment; (e) the condition of the Equipment shall be such that (i) it
qualifies for the manufacturer's standard maintenance/service agreement without
additional expense to Lessor (other than the standard charge of the manufacturer
for such agreement), (ii) the Equipment, including all electrical, hydraulic,
mechanical, and pneumatic systems, shall be operational and in the same
condition as when new, normal wear and tear excepted, (iii) all units of the
Equipment shall be capable of passing performance tests according to the
manufacturer specifications and (iv) all peripherals and additional systems on
the pieces of Equipment shall be intact and operational; (f) if the condition of
the Equipment does not satisfy the provisions of this paragraph, then Lessor at
its option may repair/replace any damage and the costs thereof shall be paid by
Lessee upon receipt of Lessor's invoice for same; (g) at the option of Lessor,
Lessee shall provide 120 days storage for the Equipment at the equipment
location(s) specified in the Lease, under power and operation, and shall permit
Lessor to show and demonstrate the Equipment to potential purchasers and third
parties, free of charge; and (h) if Lessee fails to timely return the Equipment
in satisfactory condition in accordance with the provisions of this paragraph
(i), then until the Equipment is so returned and in satisfactory condition,
Lessee shall pay to Lessor a monthly rental equal to the regular periodic
monthly rent due under the Lease Schedule for the final month of the Lease Term,
such rental to be payable monthly in advance commencing on the date that the
Equipment was due to be returned to Lessor and continuing on the same day of
each month thereafter.

         13. SEE RATE ADJUSTMENT RIDER ATTACHED AND INCORPORATED BY REFERENCE.

         By execution hereof, the signer certifies that he/she is a duly
authorized officer, partner or proprietor of Lessee and that he/she has read,
accepted and duly executed this Lease Schedule to the Master Equipment Lease
Agreement on behalf of Lessee.

ACCEPTED AT LESSOR'S OFFICE AT ALEXANDRIA, VIRGINIA.

         OXFORD VENTURE FINANCE, LLC        GENAISSANCE PHARMACEUTICALS, INC.
         (LESSOR)                           (LESSEE)

         By: /S/ J.A. PHILBRICK                      By: /S/ KEVIN RAKIN
             ---------------------------                 -----------------------
         Name: J.A. PHILBRICK                        Name:  KEVIN RAKIN
             ---------------------------                 -----------------------
         Title:  PRESIDENT                           Title:  EVP & CFO
             ---------------------------                 -----------------------
         Date:  6-10-99                              Date:  6/14/00
             ---------------------------                 -----------------------

<PAGE>



                                    EXHIBIT A

                                LIST OF EQUIPMENT

                  The following list and description of Equipment supplements
and forms a part of Lease Schedule No. 01 to Master Equipment Lease Agreement
No. 7667 dated JUNE 10, 1999 between Lessor and Lessee and may be attached to
said Lease Schedule and any related UCC Financing Statements, Acceptance
Certificate or other document relating to the Master Equipment Lease Agreement,
the Lease Schedule or any other document describing the Equipment.

                             See Attached Exhibit A

All property listed above, together with any and all attachments, accessions,
additions, replacements, improvements, modifications and substitutions thereto
and therefor and a right to use license for any software related to any of the
foregoing now or hereafter acquired and all proceeds in the form of goods,
accounts, chattel paper, documents, instruments and insurance proceeds.

         OXFORD VENTURE FINANCE, LLC           GENAISSANCE PHARMACEUTICALS, INC.

         By: /S/ J.A. PHILBRICK                By: /S/ KEVIN RAKIN
         ---------------------------           ------------------------------
         Name: J.A. PHILBRICK                  Name:  KEVIN RAKIN
         ---------------------------           ------------------------------
         Title:  PRESIDENT                     Title:  EVP & CFO
         ---------------------------           ------------------------------

<PAGE>


                                 LEASE SCHEDULE
                                       TO
                        MASTER EQUIPMENT LEASE AGREEMENT

MASTER EQUIPMENT LEASE AGREEMENT NO. 7667            DATED: JUNE 10, 1999
                                     ----                   -------------
LEASE SCHEDULE NO. 02
                   --


     LESSOR:                              LESSEE:
     OXFORD VENTURE FINANCE, LLC          GENAISSANCE PHARMACEUTICALS, INC.
     133 NORTH FAIRFAX STREET             FIVE SCIENCE PARK
     ALEXANDRIA, VIRGINIA 22314           NEW HAVEN, CT 06511

LESSOR AND LESSEE HAVE ENTERED INTO MASTER EQUIPMENT LEASE AGREEMENT NO. 7667
DATED JUNE 10, 1999 (THE "AGREEMENT") WHICH IS INCORPORATED HEREIN. THIS IS A
LEASE SCHEDULE TO THE AGREEMENT. ALL WORDS AND TERMS USED HEREIN AND NOT
SPECIFICALLY DEFINED HEREIN SHALL HAVE THE SAME MEANINGS AS SET FORTH IN THE
AGREEMENT.

         1. EQUIPMENT LOCATION (if other than above address of Lessee):

         2. EQUIPMENT: The Equipment described in the attached Exhibit A,
incorporated herein by this reference, is leased by Lessor to Lessee on the
terms specified herein and in any addendum or amendment hereto and in the
Agreement.

         3. ACQUISITION COST OF THE EQUIPMENT: $1,200,000.00

         4. SUPPLIER(S):

         5. LEASE TERM COMMENCEMENT DATE: _______________________

         6. RENTAL PAYMENTS: Lessee shall pay rent to Lessor for the Equipment,
plus applicable sales/use taxes, payable as follows:

            Advance Rent of $30,877.20 shall be due with the execution of this
Schedule.

The first Rental Payment (together with the interim rent computed as provided in
Section 4 of the Agreement) shall be due thirty (30) days following the Lease
Term Commencement Date.

The remaining Rental Payments shall be due on the same day of each consecutive
payment period thereafter for the duration of the Lease Term in the amount of
$30,877.20 on each such Rental Payment Date.

         7. LEASE TERM: 48 MONTHS

         8. SECURITY DEPOSIT: NONE

         9. DISBURSEMENT OF PROCEEDS. Lessee hereby authorizes Lessor to
disburse the $1,200,000.00 proceeds as follows:

         (a) $1,200,000.00 to: Perkin Elmer

             $1,200,000.00 TOTAL PROCEEDS:

         Lessee may direct the Lessor in writing to withhold payments from
Supplier(s), either now or in the future. Lessor shall be entitled to rely on
such written direction of Lessee as being conclusive as to the intent of the
Lessee with regard to withheld payments.


<PAGE>


         Lessee hereby acknowledges and agrees that it shall constitute an
additional Event of Default under the Lease if, for any reason, the Acquisition
Cost of the Equipment has not been fully paid to the appropriate Supplier(s)
thereof within ten (10) days after demand therefor by Lessor. Lessee hereby
agrees to indemnify, and hold harmless Lessor from and against any liability,
claim, loss or damage, including Attorneys Fees and Expenses that may be
incurred by Lessor as a result of any amounts to be withheld hereunder,
including any claims of the Supplier(s) therefor.

         10. ADJUSTMENTS: Lessee acknowledges that the Rental Payments herein,
are based upon the Acquisition Cost of the Equipment set forth above, and as a
result of authorized changes to the Equipment, the final Acquisition Cost of the
Equipment may increase or decrease by up to 10%. In such event, the Rental
Payments shall be adjusted accordingly, and Lessee authorizes Lessor to correct
the Lease (and all related documentation) to reflect such changes and Lessee, if
requested by Lessor, shall confirm such changes to Lessor in writing.

         11. SUPPLY CONTRACT: Lessee acknowledges either that (a) Lessee has
reviewed and approved any written purchase agreement or purchase order covering
the Equipment ("Supply Contract") purchased from Supplier, or (b) Lessor has
informed or advised Lessee, in writing, either previously or by the Lease, of
the following: (i) the identity of the Supplier, (ii) that Lessee may have
rights under the Supply Contract and (iii) that Lessee may contact the Supplier
for a description of any such rights Lessee may have under the Supply Contract.
If Lessee has entered into a written Supply Contract, then Lessee hereby assigns
to Lessor all of Lessee's rights and interests in and to the Equipment and the
Supply Contract. If requested by Lessor, Lessee shall obtain any consent
required for such assignment. If Lessee has not entered into any such Supply
Contract, Lessee authorizes Lessor to (and Lessor may at its option ) act on
behalf of Lessee to obtain a Supply Contract from Supplier. Except for the
obligation to pay Supplier for the Equipment, if (and only if) the Equipment is
accepted by Lessee under the Lease, such assignment shall not include any of
Lessee's obligations under such Supply Contract and Lessee shall at all times
remain liable to perform all of its duties and obligations under the Supply
Contract to the same extent as if an assignment has not occurred. Lessee hereby
represents and warrants that: (i) Lessee has delivered herewith a true and
correct copy of the Supply Contract, neither Supplier nor Lessee is in default
under the Supply Contract and it shall not be amended without Lessor's prior
written consent and (ii) the Supply Contract is free from all claims, security
interests, liens and encumbrances, except for the interest being conveyed by the
Lease. Lessee indemnifies and holds Lessor harmless with respect to any and all
claims relating to the performance of Lessee's obligations under the Supply
Contract.

         12. PURCHASE OPTION; RETURN OPTION: Lessee shall have the following
options and obligations set forth at the end of the Lease Term:

            (A) Option to Purchase Equipment. Provided no Event of Default has
occurred and is continuing under the Lease, Lessee shall have the option,
exercisable by written notice to Lessor received by Lessor at least thirty (30)
days before the expiration of the Lease Term to purchase on the day following
the last day of such Lease Term (herein "Purchase Date") all but not less than
all of the Equipment subject to the Lease for a Purchase Option Price of $1.00.
Provided Lessee has exercised its option to purchase, Lessee shall pay to Lessor
on the Purchase Date the aforementioned purchase price in cash, together with
all sales and other taxes or costs applicable to the transfer of the Equipment
and any other amounts as may be due and owing under the Lease, whereupon Lessor
shall transfer its interest in the Equipment to Lessee without recourse, on an
AS-IS, WHERE-IS basis and without any warranty, express or implied from Lessor,
other than the absence of any liens created by or through Lessor, except those
(if any) Lessee is obligated to discharge. In the event that Lessee fails to
exercise such purchase option, Lessee shall (upon termination of the Lease)
return the Equipment to Lessor upon demand, in accordance with the provisions of
the Lease.

            (B) Option to Return Equipment. Provided no Event of Default has
occurred and is continuing under the Lease, Lessee shall have the option to
return the Equipment at the end of the Lease Term in accordance with the Lease.
Lessee shall give to Lessor written notice of its election to exercise the
return option provided for in this Paragraph at least thirty (30) days prior to
the expiration of the Lease Term. The following terms and conditions shall apply
to the return of the Equipment: (a) subject to the storage/show period described
in (g) below, at the option of Lessor, Lessee shall properly de-install,
dismantle, crate and deliver the Equipment to a location designated by Lessor in
writing within the continental United States by the later of fifteen (15) days
after the end of the Lease Term or thirty (30) days after Lessor gives notice
designating the location for delivery; (b) the Equipment return, including but
not limited to de-installation, dismantling and packing shall be performed or
supervised by the manufacturer's representative and in compliance with the
manufacturer's recommendations; (c) the cost of all items related to the return
of the Equipment, including but not limited to de-installation, dismantling by
manufacturer's representative, removal, assembling, packing, insuring and
transporting the Equipment will be


<PAGE>


at the expense of Lessee; (d) the Equipment shall be shipped by a reputable
carrier (with freight and insurance prepaid) to the location designated by
Lessor and prior to shipment Lessee shall deliver to Lessor a certificate
evidencing that transit insurance is in place from the place of shipment to the
place of destination and naming Lessor as loss payee for the replacement cost of
the Equipment; (e) the condition of the Equipment shall be such that (i) it
qualifies for the manufacturer's standard maintenance/service agreement without
additional expense to Lessor (other than the standard charge of the manufacturer
for such agreement), (ii) the Equipment, including all electrical, hydraulic,
mechanical, and pneumatic systems, shall be operational and in the same
condition as when new, normal wear and tear excepted, (iii) all units of the
Equipment shall be capable of passing performance tests according to the
manufacturer specifications and (iv) all peripherals and additional systems on
the pieces of Equipment shall be intact and operational; (f) if the condition of
the Equipment does not satisfy the provisions of this paragraph, then Lessor at
its option may repair/replace any damage and the costs thereof shall be paid by
Lessee upon receipt of Lessor's invoice for same; (g) at the option of Lessor,
Lessee shall provide 120 days storage for the Equipment at the equipment
location(s) specified in the Lease, under power and operation, and shall permit
Lessor to show and demonstrate the Equipment to potential purchasers and third
parties, free of charge; and (h) if Lessee fails to timely return the Equipment
in satisfactory condition in accordance with the provisions of this paragraph
(i), then until the Equipment is so returned and in satisfactory condition,
Lessee shall pay to Lessor a monthly rental equal to the regular periodic
monthly rent due under the Lease Schedule for the final month of the Lease Term,
such rental to be payable monthly in advance commencing on the date that the
Equipment was due to be returned to Lessor and continuing on the same day of
each month thereafter.

         13. SEE RATE ADJUSTMENT RIDER ATTACHED AND INCORPORATED BY REFERENCE.

         By execution hereof, the signer certifies that he/she is a duly
authorized officer, partner or proprietor of Lessee and that he/she has read,
accepted and duly executed this Lease Schedule to the Master Equipment Lease
Agreement on behalf of Lessee.

ACCEPTED AT LESSOR'S OFFICE AT ALEXANDRIA, VIRGINIA.

         OXFORD VENTURE FINANCE, LLC      GENAISSANCE PHARMACEUTICALS, INC.
         (LESSOR)                         (LESSEE)

         By: /S/ J.A. PHILBRICK                    By: /S/ KEVIN RAKIN
           ---------------------------                 ------------------------
         Name: J. ALDEN PHILBRICK, IV              Name:  KEVIN RAKIN
           ---------------------------                 ------------------------
         Title:  PRESIDENT                         Title:  EVP & CFO
           ---------------------------                 ------------------------
         Date:  10-27-99                           Date:  10-27-99
           ---------------------------                 ------------------------


<PAGE>


                                    EXHIBIT A

                                LIST OF EQUIPMENT

            The following list and description of Equipment supplements and
forms a part of Lease Schedule No. 02 to Master Equipment Lease Agreement No.
7667 dated JUNE 10, 1999 between Lessor and Lessee and may be attached to said
Lease Schedule and any related UCC Financing Statements, Acceptance Certificate
or other document relating to the Master Equipment Lease Agreement, the Lease
Schedule or any other document describing the Equipment.

                             See Attached Exhibit A

All property listed above, together with any and all attachments, accessions,
additions, replacements, improvements, modifications and substitutions thereto
and therefor and a right to use license for any software related to any of the
foregoing now or hereafter acquired and all proceeds in the form of goods,
accounts, chattel paper, documents, instruments and insurance proceeds.

         OXFORD VENTURE FINANCE, LLC       GENAISSANCE PHARMACEUTICALS, INC.

         By: /S/ J.A. PHILBRICK                     By: /S/ KEVIN RAKIN
             -------------------------                  ---------------------
         Name: J. ALDEN PHILBRICK, IV               Name:  KEVIN RAKIN
             -------------------------                  ---------------------
         Title:  PRESIDENT                          Title:  EVP & CFO
             -------------------------                  ---------------------

<PAGE>

                                 LEASE SCHEDULE
                                       TO
                        MASTER EQUIPMENT LEASE AGREEMENT

MASTER EQUIPMENT LEASE AGREEMENT NO. 7667            DATED: JUNE 10, 1999
                                     ----                   -------------
LEASE SCHEDULE NO. 03
                   --


         LESSOR:                             LESSEE:
         OXFORD VENTURE FINANCE, LLC         GENAISSANCE PHARMACEUTICALS, INC.
         133 NORTH FAIRFAX STREET            FIVE SCIENCE PARK
         ALEXANDRIA, VIRGINIA 22314          NEW HAVEN, CT 06511

LESSOR AND LESSEE HAVE ENTERED INTO MASTER EQUIPMENT LEASE AGREEMENT NO. 7667
DATED JUNE 10, 1999 (THE "AGREEMENT") WHICH IS INCORPORATED HEREIN. THIS IS A
LEASE SCHEDULE TO THE AGREEMENT. ALL WORDS AND TERMS USED HEREIN AND NOT
SPECIFICALLY DEFINED HEREIN SHALL HAVE THE SAME MEANINGS AS SET FORTH IN THE
AGREEMENT.

         1. EQUIPMENT LOCATION (if other than above address of Lessee):

         2. EQUIPMENT: The Equipment described in the attached Exhibit A,
incorporated herein by this reference, is leased by Lessor to Lessee on the
terms specified herein and in any addendum or amendment hereto and in the
Agreement.

         3. ACQUISITION COST OF THE EQUIPMENT: $824,633.14

         4. SUPPLIER(S):

         5. LEASE TERM COMMENCEMENT DATE: _______________________

         6. RENTAL PAYMENTS: Lessee shall pay rent to Lessor for the Equipment,
plus applicable sales/use taxes, payable as follows:

            Advance Rent of $21,519.63 shall be due with the execution of this
Schedule.

The first Rental Payment (together with the interim rent computed as provided in
Section 4 of the Agreement) shall be due thirty (30) days following the Lease
Term Commencement Date.

The remaining Rental Payments shall be due on the same day of each consecutive
payment period thereafter for the duration of the Lease Term in the amount of
$21,519.63 on each such Rental Payment Date.

         7. LEASE TERM: 48 MONTHS

         8. SECURITY DEPOSIT: NONE

         9. DISBURSEMENT OF PROCEEDS. Lessee hereby authorizes Lessor to
disburse the $824,633.14 proceeds as follows:

         (a) $7,547.41   to:  VWR Scientific
         (b) $302,450.00 to:  PE Biosystems
         (c) $399,000.00 to:  SEQUENOM Industrial Genomics
         (d) $13,843.45  to:  Precision Computer
         (e) $11,204.91  to:  CDW Computer Center
         (f) $14,638.50  to:  MJ Research
         (g) $2,853.87   to:  AIR, Inc.
         (h) $73,095.00  to   Gateway Computers, Inc. ---------
             ----------

<PAGE>


             $824,633.14      TOTAL PROCEEDS:
             -----------
             -----------

         Lessee may direct the Lessor in writing to withhold payments from
Supplier(s), either now or in the future. Lessor shall be entitled to rely on
such written direction of Lessee as being conclusive as to the intent of the
Lessee with regard to withheld payments.

         Lessee hereby acknowledges and agrees that it shall constitute an
additional Event of Default under the Lease if, for any reason, the Acquisition
Cost of the Equipment has not been fully paid to the appropriate Supplier(s)
thereof within ten (10) days after demand therefor by Lessor. Lessee hereby
agrees to indemnify, and hold harmless Lessor from and against any liability,
claim, loss or damage, including Attorneys Fees and Expenses that may be
incurred by Lessor as a result of any amounts to be withheld hereunder,
including any claims of the Supplier(s) therefor.

         10. ADJUSTMENTS: Lessee acknowledges that the Rental Payments herein,
are based upon the Acquisition Cost of the Equipment set forth above, and as a
result of authorized changes to the Equipment, the final Acquisition Cost of the
Equipment may increase or decrease by up to 10%. In such event, the Rental
Payments shall be adjusted accordingly, and Lessee authorizes Lessor to correct
the Lease (and all related documentation) to reflect such changes and Lessee, if
requested by Lessor, shall confirm such changes to Lessor in writing.

         11. SUPPLY CONTRACT: Lessee acknowledges either that (a) Lessee has
reviewed and approved any written purchase agreement or purchase order covering
the Equipment ("Supply Contract") purchased from Supplier, or (b) Lessor has
informed or advised Lessee, in writing, either previously or by the Lease, of
the following: (i) the identity of the Supplier, (ii) that Lessee may have
rights under the Supply Contract and (iii) that Lessee may contact the Supplier
for a description of any such rights Lessee may have under the Supply Contract.
If Lessee has entered into a written Supply Contract, then Lessee hereby assigns
to Lessor all of Lessee's rights and interests in and to the Equipment and the
Supply Contract. If requested by Lessor, Lessee shall obtain any consent
required for such assignment. If Lessee has not entered into any such Supply
Contract, Lessee authorizes Lessor to (and Lessor may at its option ) act on
behalf of Lessee to obtain a Supply Contract from Supplier. Except for the
obligation to pay Supplier for the Equipment, if (and only if) the Equipment is
accepted by Lessee under the Lease, such assignment shall not include any of
Lessee's obligations under such Supply Contract and Lessee shall at all times
remain liable to perform all of its duties and obligations under the Supply
Contract to the same extent as if an assignment has not occurred. Lessee hereby
represents and warrants that: (i) Lessee has delivered herewith a true and
correct copy of the Supply Contract, neither Supplier nor Lessee is in default
under the Supply Contract and it shall not be amended without Lessor's prior
written consent and (ii) the Supply Contract is free from all claims, security
interests, liens and encumbrances, except for the interest being conveyed by the
Lease. Lessee indemnifies and holds Lessor harmless with respect to any and all
claims relating to the performance of Lessee's obligations under the Supply
Contract.

         12. PURCHASE OPTION; RETURN OPTION: Lessee shall have the following
options and obligations set forth at the end of the Lease Term:

             (A) Option to Purchase Equipment. Provided no Event of Default has
occurred and is continuing under the Lease, Lessee shall have the option,
exercisable by written notice to Lessor received by Lessor at least thirty (30)
days before the expiration of the Lease Term to purchase on the day following
the last day of such Lease Term (herein "Purchase Date") all but not less than
all of the Equipment subject to the Lease for a Purchase Option Price of $1.00.
Provided Lessee has exercised its option to purchase, Lessee shall pay to Lessor
on the Purchase Date the aforementioned purchase price in cash, together with
all sales and other taxes or costs applicable to the transfer of the Equipment
and any other amounts as may be due and owing under the Lease, whereupon Lessor
shall transfer its interest in the Equipment to Lessee without recourse, on an
AS-IS, WHERE-IS basis and without any warranty, express or implied from Lessor,
other than the absence of any liens created by or through Lessor, except those
(if any) Lessee is obligated to discharge. In the event that Lessee fails to
exercise such purchase option, Lessee shall (upon termination of the Lease)
return the Equipment to Lessor upon demand, in accordance with the provisions of
the Lease.

             (B) Option to Return Equipment. Provided no Event of Default has
occurred and is continuing under the Lease, Lessee shall have the option to
return the Equipment at the end of the Lease Term in accordance with the Lease.
Lessee shall give to Lessor written notice of its election to exercise the
return option provided for in this Paragraph at least thirty (30) days prior to
the expiration of the Lease Term. The following terms and conditions shall apply
to the return of the


<PAGE>


Equipment: (a) subject to the storage/show period described in (g) below, at the
option of Lessor, Lessee shall properly de-install, dismantle, crate and deliver
the Equipment to a location designated by Lessor in writing within the
continental United States by the later of fifteen (15) days after the end of the
Lease Term or thirty (30) days after Lessor gives notice designating the
location for delivery; (b) the Equipment return, including but not limited to
de-installation, dismantling and packing shall be performed or supervised by the
manufacturer's representative and in compliance with the manufacturer's
recommendations; (c) the cost of all items related to the return of the
Equipment, including but not limited to de-installation, dismantling by
manufacturer's representative, removal, assembling, packing, insuring and
transporting the Equipment will be at the expense of Lessee; (d) the Equipment
shall be shipped by a reputable carrier (with freight and insurance prepaid) to
the location designated by Lessor and prior to shipment Lessee shall deliver to
Lessor a certificate evidencing that transit insurance is in place from the
place of shipment to the place of destination and naming Lessor as loss payee
for the replacement cost of the Equipment; (e) the condition of the Equipment
shall be such that (i) it qualifies for the manufacturer's standard
maintenance/service agreement without additional expense to Lessor (other than
the standard charge of the manufacturer for such agreement), (ii) the Equipment,
including all electrical, hydraulic, mechanical, and pneumatic systems, shall be
operational and in the same condition as when new, normal wear and tear
excepted, (iii) all units of the Equipment shall be capable of passing
performance tests according to the manufacturer specifications and (iv) all
peripherals and additional systems on the pieces of Equipment shall be intact
and operational; (f) if the condition of the Equipment does not satisfy the
provisions of this paragraph, then Lessor at its option may repair/replace any
damage and the costs thereof shall be paid by Lessee upon receipt of Lessor's
invoice for same; (g) at the option of Lessor, Lessee shall provide 120 days
storage for the Equipment at the equipment location(s) specified in the Lease,
under power and operation, and shall permit Lessor to show and demonstrate the
Equipment to potential purchasers and third parties, free of charge; and (h) if
Lessee fails to timely return the Equipment in satisfactory condition in
accordance with the provisions of this paragraph (i), then until the Equipment
is so returned and in satisfactory condition, Lessee shall pay to Lessor a
monthly rental equal to the regular periodic monthly rent due under the Lease
Schedule for the final month of the Lease Term, such rental to be payable
monthly in advance commencing on the date that the Equipment was due to be
returned to Lessor and continuing on the same day of each month thereafter.

      13. SEE RATE ADJUSTMENT RIDER ATTACHED AND INCORPORATED BY REFERENCE.

         By execution hereof, the signer certifies that he/she is a duly
authorized officer, partner or proprietor of Lessee and that he/she has read,
accepted and duly executed this Lease Schedule to the Master Equipment Lease
Agreement on behalf of Lessee.

ACCEPTED AT LESSOR'S OFFICE AT ALEXANDRIA, VIRGINIA.

         OXFORD VENTURE FINANCE, LLC        GENAISSANCE PHARMACEUTICALS, INC.
         (LESSOR)                           (LESSEE)

         By: /S/ J.A. PHILBRICK                      By: /S/ KEVIN RAKIN
             ------------------------                    --------------------
         Name: J. ALDEN PHILBRICK, IV                Name:  KEVIN RAKIN
             ------------------------                    --------------------
         Title:  PRESIDENT                           Title:  EVP & CFO
             ------------------------                    --------------------
         Date:  4-24-00                              Date:  4-24-00
             ------------------------                    --------------------

<PAGE>



                                    EXHIBIT A

                                LIST OF EQUIPMENT

             The following list and description of Equipment supplements and
forms a part of Lease Schedule No. 03 to Master Equipment Lease Agreement No.
7667 dated JUNE 10, 1999 between Lessor and Lessee and may be attached to said
Lease Schedule and any related UCC Financing Statements, Acceptance Certificate
or other document relating to the Master Equipment Lease Agreement, the Lease
Schedule or any other document describing the Equipment.

                             See Attached Exhibit A

All property listed above, together with any and all attachments, accessions,
additions, replacements, improvements, modifications and substitutions thereto
and therefor and a right to use license for any software related to any of the
foregoing now or hereafter acquired and all proceeds in the form of goods,
accounts, chattel paper, documents, instruments and insurance proceeds.

         OXFORD VENTURE FINANCE, LLC       GENAISSANCE PHARMACEUTICALS, INC.

         By: /S/ J.A. PHILBRICK                     By: /S/ KEVIN RAKIN
              -----------------------                   --------------------
         Name: J. ALDEN PHILBRICK, IV               Name:  KEVIN RAKIN
              -----------------------                   --------------------
         Title:  PRESIDENT                          Title:  EVP & CFO
              -----------------------                   --------------------

<PAGE>


                                 LEASE SCHEDULE
                                       TO
                        MASTER EQUIPMENT LEASE AGREEMENT

MASTER EQUIPMENT LEASE AGREEMENT NO. 7667            DATED: JUNE 10, 1999
                                     ----                   -------------
LEASE SCHEDULE NO. 04
                   --


         LESSOR:                           LESSEE:

         OXFORD VENTURE FINANCE, LLC       GENAISSANCE PHARMACEUTICALS, INC.
         133 NORTH FAIRFAX STREET          FIVE SCIENCE PARK
         ALEXANDRIA, VIRGINIA 22314        NEW HAVEN, CT 06511

LESSOR AND LESSEE HAVE ENTERED INTO MASTER EQUIPMENT LEASE AGREEMENT NO. 7667
DATED JUNE 10, 1999 (THE "AGREEMENT") WHICH IS INCORPORATED HEREIN. THIS IS A
LEASE SCHEDULE TO THE AGREEMENT. ALL WORDS AND TERMS USED HEREIN AND NOT
SPECIFICALLY DEFINED HEREIN SHALL HAVE THE SAME MEANINGS AS SET FORTH IN THE
AGREEMENT.

            1. EQUIPMENT LOCATION (if other than above address of Lessee):

            2. EQUIPMENT: The Equipment described in the attached Exhibit A,
incorporated herein by this reference, is leased by Lessor to Lessee on the
terms specified herein and in any addendum or amendment hereto and in the
Agreement.

            3. ACQUISITION COST OF THE EQUIPMENT: $659,864.45

            4. SUPPLIER(S):

            5. LEASE TERM COMMENCEMENT DATE: _______________________

            6. RENTAL PAYMENTS: Lessee shall pay rent to Lessor for the
Equipment, plus applicable sales/use taxes, payable as follows:

               Advance Rent of $17,219.82 shall be due with the execution of
this Schedule.

The first Rental Payment (together with the interim rent computed as provided in
Section 4 of the Agreement) shall be due thirty (30) days following the Lease
Term Commencement Date.

The remaining Rental Payments shall be due on the same day of each consecutive
payment period thereafter for the duration of the Lease Term in the amount of
$17,219.82 on each such Rental Payment Date.

            7. LEASE TERM: 48 MONTHS

            8. SECURITY DEPOSIT: NONE

            9. DISBURSEMENT OF PROCEEDS. Lessee hereby authorizes Lessor to
disburse the $659,864.45 proceeds as follows:

            (a) $619,020.00 to: PE Biosystems
            (b) $ 14,411.80 to  Franek Technologies
            (c) $  9,465.00 to: Dell
            (d) $ 14,603.61 to: Corporate Technologies
            (e) $  2,364.04 to: VWR Scientific
                -----------
                $659,864.45            TOTAL PROCEEDS
                -----------
                -----------
<PAGE>


         Lessee may direct the Lessor in writing to withhold payments from
Supplier(s), either now or in the future. Lessor shall be entitled to rely on
such written direction of Lessee as being conclusive as to the intent of the
Lessee with regard to withheld payments.

         Lessee hereby acknowledges and agrees that it shall constitute an
additional Event of Default under the Lease if, for any reason, the Acquisition
Cost of the Equipment has not been fully paid to the appropriate Supplier(s)
thereof within ten (10) days after demand therefor by Lessor. Lessee hereby
agrees to indemnify, and hold harmless Lessor from and against any liability,
claim, loss or damage, including Attorneys Fees and Expenses that may be
incurred by Lessor as a result of any amounts to be withheld hereunder,
including any claims of the Supplier(s) therefor.

         10. ADJUSTMENTS: Lessee acknowledges that the Rental Payments herein,
are based upon the Acquisition Cost of the Equipment set forth above, and as a
result of authorized changes to the Equipment, the final Acquisition Cost of the
Equipment may increase or decrease by up to 10%. In such event, the Rental
Payments shall be adjusted accordingly, and Lessee authorizes Lessor to correct
the Lease (and all related documentation) to reflect such changes and Lessee, if
requested by Lessor, shall confirm such changes to Lessor in writing.

         11. SUPPLY CONTRACT: Lessee acknowledges either that (a) Lessee has
reviewed and approved any written purchase agreement or purchase order covering
the Equipment ("Supply Contract") purchased from Supplier, or (b) Lessor has
informed or advised Lessee, in writing, either previously or by the Lease, of
the following: (i) the identity of the Supplier, (ii) that Lessee may have
rights under the Supply Contract and (iii) that Lessee may contact the Supplier
for a description of any such rights Lessee may have under the Supply Contract.
If Lessee has entered into a written Supply Contract, then Lessee hereby assigns
to Lessor all of Lessee's rights and interests in and to the Equipment and the
Supply Contract. If requested by Lessor, Lessee shall obtain any consent
required for such assignment. If Lessee has not entered into any such Supply
Contract, Lessee authorizes Lessor to (and Lessor may at its option ) act on
behalf of Lessee to obtain a Supply Contract from Supplier. Except for the
obligation to pay Supplier for the Equipment, if (and only if) the Equipment is
accepted by Lessee under the Lease, such assignment shall not include any of
Lessee's obligations under such Supply Contract and Lessee shall at all times
remain liable to perform all of its duties and obligations under the Supply
Contract to the same extent as if an assignment has not occurred. Lessee hereby
represents and warrants that: (i) Lessee has delivered herewith a true and
correct copy of the Supply Contract, neither Supplier nor Lessee is in default
under the Supply Contract and it shall not be amended without Lessor's prior
written consent and (ii) the Supply Contract is free from all claims, security
interests, liens and encumbrances, except for the interest being conveyed by the
Lease. Lessee indemnifies and holds Lessor harmless with respect to any and all
claims relating to the performance of Lessee's obligations under the Supply
Contract.

         12. PURCHASE OPTION; RETURN OPTION: Lessee shall have the following
options and obligations set forth at the end of the Lease Term:

             (A) Option to Purchase Equipment. Provided no Event of Default has
occurred and is continuing under the Lease, Lessee shall have the option,
exercisable by written notice to Lessor received by Lessor at least thirty (30)
days before the expiration of the Lease Term to purchase on the day following
the last day of such Lease Term (herein "Purchase Date") all but not less than
all of the Equipment subject to the Lease for a Purchase Option Price of $1.00.
Provided Lessee has exercised its option to purchase, Lessee shall pay to Lessor
on the Purchase Date the aforementioned purchase price in cash, together with
all sales and other taxes or costs applicable to the transfer of the Equipment
and any other amounts as may be due and owing under the Lease, whereupon Lessor
shall transfer its interest in the Equipment to Lessee without recourse, on an
AS-IS, WHERE-IS basis and without any warranty, express or implied from Lessor,
other than the absence of any liens created by or through Lessor, except those
(if any) Lessee is obligated to discharge. In the event that Lessee fails to
exercise such purchase option, Lessee shall (upon termination of the Lease)
return the Equipment to Lessor upon demand, in accordance with the provisions of
the Lease.

             (B) Option to Return Equipment. Provided no Event of Default has
occurred and is continuing under the Lease, Lessee shall have the option to
return the Equipment at the end of the Lease Term in accordance with the Lease.
Lessee shall give to Lessor written notice of its election to exercise the
return option provided for in this Paragraph at least thirty (30) days prior to
the expiration of the Lease Term. The following terms and conditions shall apply
to the return of the Equipment: (a) subject to the storage/show period described
in (g) below, at the option of Lessor, Lessee shall properly de-install,
dismantle, crate and deliver the Equipment to a location designated by Lessor in
writing within the continental


<PAGE>


United States by the later of fifteen (15) days after the end of the Lease
Term or thirty (30) days after Lessor gives notice designating the location
for delivery; (b) the Equipment return, including but not limited to
de-installation, dismantling and packing shall be performed or supervised by
the manufacturer's representative and in compliance with the manufacturer's
recommendations; (c) the cost of all items related to the return of the
Equipment, including but not limited to de-installation, dismantling by
manufacturer's representative, removal, assembling, packing, insuring and
transporting the Equipment will be at the expense of Lessee; (d) the
Equipment shall be shipped by a reputable carrier (with freight and insurance
prepaid) to the location designated by Lessor and prior to shipment Lessee
shall deliver to Lessor a certificate evidencing that transit insurance is in
place from the place of shipment to the place of destination and naming
Lessor as loss payee for the replacement cost of the Equipment; (e) the
condition of the Equipment shall be such that (i) it qualifies for the
manufacturer's standard maintenance/service agreement without additional
expense to Lessor (other than the standard charge of the manufacturer for
such agreement), (ii) the Equipment, including all electrical, hydraulic,
mechanical, and pneumatic systems, shall be operational and in the same
condition as when new, normal wear and tear excepted, (iii) all units of the
Equipment shall be capable of passing performance tests according to the
manufacturer specifications and (iv) all peripherals and additional systems
on the pieces of Equipment shall be intact and operational; (f) if the
condition of the Equipment does not satisfy the provisions of this paragraph,
then Lessor at its option may repair/replace any damage and the costs thereof
shall be paid by Lessee upon receipt of Lessor's invoice for same; (g) at the
option of Lessor, Lessee shall provide 120 days storage for the Equipment at
the equipment location(s) specified in the Lease, under power and operation,
and shall permit Lessor to show and demonstrate the Equipment to potential
purchasers and third parties, free of charge; and (h) if Lessee fails to
timely return the Equipment in satisfactory condition in accordance with the
provisions of this paragraph (i), then until the Equipment is so returned and
in satisfactory condition, Lessee shall pay to Lessor a monthly rental equal
to the regular periodic monthly rent due under the Lease Schedule for the
final month of the Lease Term, such rental to be payable monthly in advance
commencing on the date that the Equipment was due to be returned to Lessor
and continuing on the same day of each month thereafter.

         13. SEE RATE ADJUSTMENT RIDER ATTACHED AND INCORPORATED BY REFERENCE.

         By execution hereof, the signer certifies that he/she is a duly
authorized officer, partner or proprietor of Lessee and that he/she has read,
accepted and duly executed this Lease Schedule to the Master Equipment Lease
Agreement on behalf of Lessee.

ACCEPTED AT LESSOR'S OFFICE AT ALEXANDRIA, VIRGINIA.

         OXFORD VENTURE FINANCE, LLC      GENAISSANCE PHARMACEUTICALS, INC.
         (LESSOR)                         (LESSEE)

         By: /S/ J.A. PHILBRICK                    By: /S/ KEVIN RAKIN
             ------------------------                  --------------------
         Name: J. ALDEN PHILBRICK, IV              Name:  KEVIN RAKIN
             ------------------------                  --------------------
         Title:  PRESIDENT                         Title:  EVP & CFO
             ------------------------                  --------------------
         Date:                                     Date:
             ------------------------                  --------------------

<PAGE>



                                    EXHIBIT A

                                LIST OF EQUIPMENT

         The following list and description of Equipment supplements and forms a
part of Lease Schedule No. 04 to Master Equipment Lease Agreement No. 7667 dated
JUNE 10, 1999 between Lessor and Lessee and may be attached to said Lease
Schedule and any related UCC Financing Statements, Acceptance Certificate or
other document relating to the Master Equipment Lease Agreement, the Lease
Schedule or any other document describing the Equipment.

                             See Attached Exhibit A

All property listed above, together with any and all attachments, accessions,
additions, replacements, improvements, modifications and substitutions thereto
and therefor and a right to use license for any software related to any of the
foregoing now or hereafter acquired and all proceeds in the form of goods,
accounts, chattel paper, documents, instruments and insurance proceeds.

         OXFORD VENTURE FINANCE, LLC         GENAISSANCE PHARMACEUTICALS, INC.

         By: /S/ J.A. PHILBRICK                       By: /S/ KEVIN RAKIN
             ------------------------                     --------------------
         Name: J. ALDEN PHILBRICK, IV                 Name:  KEVIN RAKIN
             ------------------------                     --------------------
         Title:  PRESIDENT                            Title:  EVP & CFO
             ------------------------                     --------------------