Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

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430736

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND

 POLLUTION PREVENTION

MEMORANDUM

Date: December 23, 2015

 

SUBJECT: Emamectin Benzoate: Acute and Chronic Aggregate Dietary (Food and 

Drinking Water) Exposure and Risk Assessments using Updated Percent 

Crop Treated.

PC Code: 122806 DP Barcode: D430736

Decision No.: 495169 Registration No.: NA

Petition No.: NA Regulatory Action: Section 3 Registration 

Risk Assessment Type: Dietary Case No.: NA

TXR No.: NA CAS Nos.: 155569-91-8 (emamectin benzoate)

 119791-41-2 (emamectin)

MRID No.: NA 40 CFR: §180.505

FROM: Nancy Dodd, Chemist

Risk Assessment Branch III (RAB3)

Health Effects Division (HED; 7509P)

THROUGH: David Hrdy, Senior Scientist

Jennifer R. Tyler, Chemist

Dietary Exposure Science Advisory Council (DESAC)

HED (7509P)

and

Christine Olinger, Branch Chief

RAB3/HED (7509P)

TO: Meredith Laws, Branch Chief

Mark Suarez /Jessica Rogala, RM#7

Invertebrate and Vertebrate Branch 3

Registration Division (RD; 7505P)
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

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Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk 

assessments were conducted using the Dietary Exposure Evaluation Model software with 

the Food Commodity Intake Database (DEEM-FCID), Version 3.16. This software uses

2003-2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) 

National Health and Nutrition Examination Survey, What We Eat in America 

(NHANES/WWEIA). The analyses were conducted using updated percent crop treated 

data dated 7/15/15 in support of a screening assessment of combined residues of 

abamectin and emamectin to support a human health risk assessment on abamectin 

(D423301, L. Nollen, 04/18/16). No other changes were made to the prior emamectin

input files. This memorandum was reviewed by two peer reviewers of the DESAC, per 

the current DESAC Standard Operating Procedure (SOP).

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

A probabilistic acute dietary exposure assessment was conducted. The anticipated 

residue estimates, used for most crops, were based on field trial data. Tolerance-level 

residues were used for tree nuts, cottonseed oil, and wine. Pesticide Data Program (PDP)

monitoring data for years 2009 and 2010 were used for apples since apple juice had a 

significant impact on exposure. DEEM default processing factors were used except for 

commodities with chemical-specific processing studies. Percent crop treated (PCT or %

CT) data provided by the Biological and Economic Analysis Division (BEAD) in 2015

were used. The estimated drinking water concentrations (EDWCs) of emamectin 

benzoate were provided by the Environmental Fate and Effects Division (EFED). A

drinking water residue distribution based on the Pesticide Root Zone Model/Exposure 

Analysis Modeling System (PRZM/EXAMS) modeling of the use on ornamentals was 

used in the acute assessment.

The acute dietary exposure estimates for food and drinking water using the ornamentals

scenario for drinking water are below HED’s level of concern at the 99.9th percentile of 

exposure for all population subgroups (6.9% of the aPAD for the general U.S. population 

and 9.0% of the aPAD for females 13-49 years old, the most highly exposed population 

subgroup).

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

A somewhat refined chronic dietary exposure assessment was conducted. The 

anticipated residue estimates, used for most crops, were single point estimates (averages) 

based on field trial data. Tolerance-level residues were used for tree nuts (including 

pistachios), cottonseed oil, and wine. DEEM default processing factors were used except 

for commodities with chemical-specific processing studies. PCT data provided by BEAD 

in 2015 were used. The EDWC of 0.150 μg/L (ppb) for the chronic exposure was based 

on PRZM/EXAMS modeling of the use on ornamentals, which resulted in the highest 

chronic EDWC considering all proposed/registered uses. 
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The chronic dietary exposure estimates for food and drinking water using the ornamentals 

scenario for drinking water are below HED’s level of concern for all population 

subgroups (<1% of the cPAD for the general U.S. population and <1% of the cPAD for

all infants less than 1 year old and children 1-2 years old, which are tied for the most 

highly exposed population subgroup). 

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

Emamectin benzoate is classified as “not likely to be carcinogenic to humans” based on 

the rodent carcinogenicity studies.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population adjusted dose (PAD). 

The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by 

the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary 

risk exceeds 100% of the PAD. References which discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: “Available 

Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, 

web link: http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2007-0780-

0001; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for emamectin benzoate was conducted by 

Nancy Dodd (15-APR-2015, D426800). D426800 updated D402152 (N. Dodd, 20-FEB2013) with revised toxicology endpoints for both the acute and chronic assessments (i.e., 

aPAD = 0.0025 mg/kg bw/day; cPAD = 0.0025 mg/kg bw/day). The current memo 

D430736 updates D426800 with percent crop treated data provided in 2015. No new 

crops have been added since D402152.

II. Residue Information

Tolerances: Tolerances for plant commodities have been established under 40 CFR 

§180.505(a)(1) for emamectin, including its metabolites and degradates. Compliance 

with the tolerance levels specified is to be determined by measuring only the sum of 

emamectin (a mixture of a minimum of 90% 4'-epi-methylamino-4'-deoxyavermectin B1a

and maximum of 10% 4'-epi-methylamino-4'-deoxyavermectin B1b) and its metabolites 

8,9-isomer of the B1a and B1b component of the parent (8,9-ZMA), or 4'-deoxy-4'-epiamino-avermectin B1a and 4'-deoxy-4'-epi-amino-avermectin B1b; 4'-deoxy-4'-epi-aminoavermectin B1a (AB1a); 4'-deoxy-4'-epi-(N-formyl-N-methyl)amino-avermectin (MFB1a); 

and 4'-deoxy-4'-epi-(N-formyl)amino-avermectin B1a (FAB1a), calculated as the 

stoichiometric equivalent of emamectin, at levels ranging from 0.02 ppm to 0.20 ppm. 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

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Tolerances for livestock commodities have been established under 40 CFR 

§180.505(a)(2) for emamectin, including its metabolites and degradates. Compliance 

with the tolerance levels specified is to be determined by measuring only the sum of 

emamectin (MAB1a + MAB1b isomers) and the associated 8,9-Z isomers (8,9-ZB1a + 8,9-

ZB1b). The established tolerance levels are 0.010 ppm for the fat of cattle, goat, horse, 

and sheep; 0.050 ppm for the liver of cattle, goat, horse, and sheep; 0.003 ppm for the 

meat of cattle, goat, horse, and sheep; 0.020 ppm for the meat byproducts except liver of 

cattle, goat, horse, and sheep; 0.003 ppm for hog fat; 0.020 ppm for hog liver; 0.002 ppm 

for hog meat; 0.005 ppm for hog meat byproducts except liver; and 0.003 ppm for milk. 

No tolerances have been established for poultry commodities.

Residues of Concern: The residues of concern in plants for the tolerance expression and 

dietary risk assessment are emamectin (MAB1a + MAB1b), the associated 8,9-Z isomers 

(8,9-ZB1a + 8,9-ZB1b), and metabolites/degradates AB1a, MFB1a, and FAB1a. For 

ruminant commodities, emamectin (MAB1a + MAB1b) and its 8,9-Z isomers (8,9-ZB1a + 

8,9-ZB1b) are included in the tolerance expression and dietary risk assessment. 

Residues in Crops:

Acute assessment: A probabilistic acute dietary exposure assessment was conducted. 

The anticipated residue estimates, used for most crops, were based on field trial data. 

Tolerance-level residues were used for tree nuts (including pistachios), cottonseed oil, 

and wine. PDP monitoring data for years 2009 and 2010 were used for apples since 

apple juice had a significant impact on exposure. DEEM default processing factors were 

used except for commodities with chemical-specific processing studies. PCT data 

provided by the BEAD in 2015 were used.

 

Chronic assessment: A somewhat refined chronic dietary exposure assessment was 

conducted. The anticipated residue estimates, used for most crops, were single point 

estimates (averages) based on field trial data. Tolerance-level residues were used for tree 

nuts (including pistachios), cottonseed oil, and wine. DEEM default processing factors 

were used except for commodities with chemical-specific processing studies. PCT data 

provided by BEAD in 2015 were used. 

PDP monitoring data for apples were used in the acute assessment since apple juice has a 

significant impact on exposure. The total number of apple samples from years 2009 and 

2010 was 1278 with no detects at a limit of detection (LOD) of 0.001 ppm.

For both acute and chronic assessments, field trial residue data were translated from 

representative crops to other commodities in the crop group/subgroup according to the 

following guidance document: “Guidance for Translation of Field Trial Data from 

Representative Commodities in the Crop Group Regulation to Other Commodities in 

Each Crop Group/Subgroup, HED Standard Operating Procedure 2000.1 (9/12/2000).”
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Processed Commodities: Processing studies are available on apples (MRID 45899801), 

tomatoes (MRID 46587002), cottonseed (MRID 44883716), and wine (MRIDs 48758308 

and 48758316). The studies show that residues do not concentrate in apple juice, tomato 

paste, tomato puree, cottonseed oil, and wine. A processing factor of 1.0x is used for 

apple juice, tomato paste, tomato puree, and cottonseed oil; the processing factor of 0.29x 

is used for wine. The apple juice processing factor is translated to pear juice (1.0x). 

DEEM default processing factors are applied to other processed commodities: apples, 

dried (8.0x); pears, dried (6.25x); tomato juice (1.5x); tomato, dried (14.3x); and beef, 

meat, dried (1.92x). (Note: Although a separate tolerance was established for tomato 

paste in 40 CFR §180.505, a subsequent tomato processing study indicated that residues 

are not expected to concentrate in tomato paste; therefore, the processing factor of 1.0x is 

used for tomato paste.) 

Meat, Milk, Poultry, and Eggs: Residues in livestock commodities are based on the 

livestock dietary burdens from Table 1 and the feeding study results from Table 2. 

Table 1. Livestock Maximum Reasonable Dietary Burdens for Emamectin Benzoate.

1

% Diet Dietary Contributions (ppm)

Feedstuff Type Tolerance, 

ppm

% Dry 

Matter

Beef Dairy Poultry Swine Beef Dairy Poultry Swine

Almond hulls R 0.0553 90 NU2 10 NU NU 0 0.0061 0 0

Cotton gin 

byproducts

R 0.050 90 5 NU NU NU 0.0028 0 0 0

Cotton hulls R 0.025 90 10 NU NU NU 0.0028 0 0 0

Untreated R 0 --- 0 35 0 0 0 0 0 0

Apple

pomace, wet

CC 0.075 40 NU2 10 NU NU 0 0.019 0 0

Untreated CC 0 -- 80 35 75 85 0 0 0 0

Cotton meal PC 0.025 89 5 -- 20 15 0.0014 0 0.0056 0.0042

Cotton, 

undelinted 

seed

PC 0.025 88 NU 10 NU NU 0 0.0028 0 0

Untreated PC 0 --- 0 0 5 0 0 0 0 0

Totals 100 100 100 100 0.0070 0.028 0.0056 0.0042 1 All data are based on Table 1 Feedstuffs (June 2008). Residue levels for beef and dairy cattle are 

corrected for moisture content and are determined by the following formula: tolerance ÷ % dry matter x % 

in diet. Residue levels for poultry and swine are considered “as-is” and are determined by the following 

formula: tolerance x % in diet.

2 NU = Not Used.

3 Almond hulls are partially blended. The average residue value (0.055 ppm from MRID 47243301) is 

used for dairy cattle feed items. The HAFT of 0.0985 ppm would be used for beef cattle, poultry, or swine.

An adequate cattle feeding study was submitted in conjunction with a previous petition 

(PP#7F04845, D267346, M. Xue, 2/19/02). The maximum residues observed in cattle 

matrices at each of the dosing levels are presented in Table 2 below. The reported LODs 

and limits of quantitation (LOQs) for each analyte were 0.001 and 0.002 ppm, 
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respectively, in liver, kidney, muscle, and fat; 0.0001 and 0.0005 ppm, respectively, in 

milk (whole and skim); and 0.00025 and 0.0005 ppm, respectively, in cream. 

Since all dietary burdens in Table 1 above are <0.03 ppm, the residues from the low dose 

(0.03 ppm) cattle feeding study were used in the dietary assessments as the residue levels 

in livestock commodities. Component residues used in the dietary assessment for whole 

milk and cream are bolded in Table 2 below. Component residues used for fat, kidney, 

liver, and meat (muscle) are also bolded. For residues reported as <LOD or <LOQ, 1⁄2 the 

LOD or 1⁄2 the LOQ was used to sum the component residues. The total residues used in 

the assessment were 0.003 ppm for fat, 0.0045 ppm for kidney, 0.01 ppm for liver, 0.002 

ppm for meat, and 0.01 ppm for meat byproducts of cattle, goat, hog, horse, and sheep; 

0.0003 ppm for milk, and 0.002 ppm for cream. No poultry commodity tolerances have 

been established.

Table 2. Maximum Residues Observed in Cattle Matrices in the Cattle Feeding Study.

2

Matrix

Low Dose (0.030 ppm) Mid Dose (0.090 ppm) High Dose (0.300 ppm)

MAB1a + 

8,9-Z B1a

MAB1b + 

8,9-Z B1b

MAB1a + 

8,9-Z B1a

MAB1b + 

8,9-Z B1b

MAB1a + 

8,9-Z B1a

MAB1b + 

8,9-Z B1b

Whole milk <0.0005 <0.0001 0.0010 <0.0005 0.0053 0.0006 1

Skim milk <0.0005 <0.0001 0.0007 <0.0001 0.0030 <0.0005

Cream 0.0021 <0.0001 0.0046 <0.0005 0.021 0.0017 1

Fat 0.0022 <0.001 0.0066 <0.002 0.015 <0.002 

Kidney 0.0040 <0.001 0.013 <0.001 0.042 0.0036 1

Liver 0.010 <0.001 0.029 0.0022 0.115 0.0090 1

Muscle <0.002 <0.001 0.0020 <0.001 0.0064 <0.001

1 This value represents the result for MAB1b + 8,9-Z B1b in the sample containing the maximum residues of 

MAB1a + 8,9-Z B1a. 2 Component residues used in the dietary assessment are bolded. For residues reported as <LOD or <LOQ, 

1⁄2 the LOD or 1⁄2 the LOQ was used to sum the component residues. 

Catfish/Fish: The USDA Pesticide Data Program (PDP) monitored pesticide residues in 

catfish/fish in 2008, 2009, and 2010; however, the samples were not analyzed for 

emamectin benzoate. As a result, residues in catfish/fish were not included in the 

assessment.

Residue Data used for the Acute Dietary (Food + Drinking Water) Assessment:

A probabilistic acute dietary exposure assessment was conducted. The anticipated 

residue estimates, used for most crops, were based on field trial data. Tolerance-level 

residues were used for tree nuts (including pistachios), cottonseed oil, and wine. PDP

monitoring data for years 2009 and 2010 were used for apples since apple juice had a 

significant impact on exposure. DEEM default processing factors were used except for 

commodities with available chemical-specific processing studies. PCT data provided by 

BEAD in 2015 were used. The EDWCs of emamectin benzoate were provided by EFED. 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

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A drinking water residue distribution based on the PRZM/EXAMS modeling of the use 

on ornamentals was used in the acute assessment.

Residue Data used for the Chronic Dietary (Food + Drinking Water) Assessment:

A somewhat refined chronic dietary exposure assessment was conducted. The 

anticipated residue estimates, used for most crops, were single point estimates (averages) 

based on field trial data. Tolerance-level residues were used for tree nuts (including 

pistachios), cottonseed oil, and wine. DEEM default processing factors were used except 

for commodities with chemical-specific processing studies. PCT data provided by BEAD 

in 2015 were used. The EDWC of 0.150 μg/L (ppb) for the chronic exposure was based 

on PRZM/EXAMS modeling of the use on ornamentals, which resulted in the highest 

chronic EDWC considering all proposed/registered uses.

III. Percent Crop Treated Information

A screening level usage analysis (SLUA) dated 7/15/15 was provided by BEAD based on 

data years 2004-2013. (Refer to Attachment 2). The estimated maximum PCT for each 

of seventeen crops was used for the acute dietary risk assessment and the estimated 

weighted average PCT was used for the chronic dietary risk assessment.

The following maximum PCT estimates (SLUA, 7/15/15) were used in the acute dietary 

risk assessment for the following crops that are currently registered for emamectin 

benzoate: almonds: 10%; apples: 20%; broccoli: 20%; Brussels sprouts: 40%; cabbage: 

25%; cauliflower: 20%; celery: 40%; cotton: 2.5%; cucumber: 2.5%; endive (grown from 

chicory): 10%; lettuce: 20%; pears: 20%; peppers: 15%; pistachios: 2.5%; spinach: 10%; 

tomatoes: 20%; and walnuts: 2.5%.

The following average PCT estimates (SLUA, 7/15/15) were used in the chronic dietary 

risk assessment for the following crops that are currently registered for emamectin 

benzoate: almonds: 5%; apples: 10%; broccoli: 5%; Brussels sprouts: 20%; cabbage: 

10%; cauliflower: 5%; celery: 20%; cotton: 1%; cucumber: 2.5%; endive (grown from 

chicory): 2.5%; lettuce: 10%; pears: 5%; peppers: 5%; pistachios: 2.5%; spinach: 5%; 

tomatoes: 10%; and walnuts: 2.5%.

For livestock commodities, the PCT for apples was used in the residue distribution files 

(RDFs) for beef and dairy cattle; the PCT for cotton (the only poultry/swine feed item) 

was used in the RDFs for swine.
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IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by EFED 

in the following memorandum: “Amended Drinking Water Assessment for the Proposed 

Use of Emamectin Benzoate on Outdoor Ornamentals and Group 9 Cucurbit Vegetables”

(DP#402307, Tiffany Dowen, 5/30/12) and incorporated directly into this dietary 

assessment. Water residues were incorporated in the DEEM-FCID into the food 

categories “water, direct, all sources” and “water, indirect, all sources.” 

EDWCs from use on outdoor-grown ornamentals are the highest. Emamectin benzoate 

residues (parent + degradation products), based on applications made to ornamentals and 

group 9 cucurbits, are not expected to exceed 0.465 μg/L for the 1 in 10 year daily peak, 

0.150 μg/L for the 1 in 10 year annual average, and 0.112 μg/L for the 30 year annual 

average (Table 3). A distribution of drinking water numbers using the ornamentals 

scenario was used in the acute assessment. The EDWC of 0.150 μg/L was used in the 

chronic assessment.

The Agency identified four degradates of concern based on structural similarity to 

emamectin benzoate that are formed via photolysis (MARC memo references: D238206, 

Sept 2, 1997; D255357, Aug 20, 2001; D277085, Aug 20, 2001): 

• (8,9-Z)-4"-epimethylamino-4"-deoxy avermectin B1 (8,9 ZMA isomer); 

• 4"-epiamino-4"-deoxyavermectin B1 (AB);

• avermectin B1 monosaccharide (MAB); and 

• 4"-epi-(N-formyl)-4"-deoxyavermectin B1 (FAB).

These degradates were included in the drinking water assessment for emamectin benzoate 

and are assumed to be of equal or lesser toxicity to that of the parent compound. The 

total toxic residues approach is used for determining the environmental fate data 

parameters for modeling using the Guidance for Selecting Input Parameters in Modeling 

the Environmental Fate and Transport of Pesticides, Version 2.1, October 22, 2009, and 

the draft Guidance for Modeling Pesticides Total Toxic Residues (TTR), dated May 20, 

2009.

Table 3. EDWCs for Emamectin Benzoate Residues from Use on Outdoor Ornamentals and 

Group 9 Cucurbit Vegetables.

1

Use Model

1 in 10 year 30 year Annual 

Peak Annual Mean Average

μg/L

Surface Water

Ornamentals PRZM/EXAMS2 0.465 0.150 0.112

Ground Water

Ornamentals/Group 9 

Cucurbit Vegetables SCI-GROW 0.54 x 10-3 0.54 x 10-3 0.54 x 10-3
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1 Degradates of concern included in the calculation of EDWCs: (8,9-Z)-4"-epimethylamino-4"-deoxy 

avermectin B1, 4"-epiamino-4"-deoxyavermectin B1, avermectin B1 monosaccharide, and 4"-epi-(Nformyl)-4"-deoxyavermectin B1 (the 8,9 ZMA isomer, AB, MAB, and FAB, respectively). 2 Typically, the values generated by the models for drinking water are multiplied by a percent crop area 

factor (PCA). The PCA accounts for the fact that is it unlikely for any basin to be completely planted to 

agricultural crops. The PCA adjustment factor is assumed to be 0.87 for the group 9 cucurbit vegetables 

and 1.0 for the outdoor ornamentals crops as per the PCA guidance. 

The model and its description are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 

V. DEEM-FCID Program and Consumption Information

Emamectin benzoate acute and chronic dietary exposure assessments were conducted 

using DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption data from 

USDA’s NHANES/WWEIA. The data are based on the reported consumption of more 

than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” 

(e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit -

cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly 

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire U.S. population and 

within population subgroups. However, for acute exposure assessment, consumption 

data are retained as individual consumption events. Based on analysis of the 2003-2008 

WWEIA consumption data, which took into account dietary patterns and survey 

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99

years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cPAD. This procedure is performed for each 

population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on 

an individual-by-individual basis. The reported consumption amounts of each food item 

can be multiplied by a residue point estimate and summed to obtain a total daily pesticide 

exposure for a deterministic exposure assessment, or “matched” in multiple random 

pairings with residue values and then summed in a probabilistic assessment. The 

resulting distribution of exposures is expressed as a percentage of the aPAD on both a 

user (i.e., only those who reported eating relevant commodities/food forms) and a percapita (i.e., those who reported eating the relevant commodities as well as those who did 
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not) basis. In accordance with HED policy, per capita exposure and risk are reported for 

analyses performed at all levels of refinement. However, for deterministic assessments, 

any significant differences in user vs. per capita exposure and risk are specifically 

identified and noted in the risk assessment.

VI. Toxicological Information

The Agency has re-evaluated the entire emamectin toxicological database (D426599, N. 

Dodd, 4/15/15). The toxicity endpoint and point of departure for all exposure scenarios 

are now selected from the subchronic and chronic oral toxicity studies in dogs. A waiver 

has been granted for the subchronic inhalation toxicity study (HASPOC Report: TXR No. 

0051377, 3/12/15). No additional toxicology studies are required at this time.

The points of departure selected from the dog studies are based on clear NOAELs and are 

protective of all adverse effects seen in human-relevant studies conducted in rats, CD-1 

mice, and rabbits. Therefore, the FQPA safety factor has been reduced to 1x.

The doses and toxicological endpoints selected for use in dietary exposure assessments 

are summarized in Table 4.

Table 4. Summary of Toxicological Doses and Endpoints for Emamectin benzoate for Use in Dietary 

Exposure Assessments.

1

Exposure/

Scenario

POD Uncertainty/

FQPA Safety 

Factors

RfD, PAD, Level 

of Concern for 

Risk Assessment

Study and Toxicological 

Effects

Acute Dietary 

(All 

Populations)

NOAEL = 0.25 

mg/kg/day

UFA = 10x

UFH = 10x

FQPA SF = 

1x

Acute RfD = 

0.0025 

mg/kg/day

Subchronic and chronic oral 

toxicity studies in dogs

Subchronic LOAEL = 0.5 

mg/kg/day based skeletal 

muscle atrophy and white 

matter multifocal degeneration 

in the brains of both sexes and 

white matter multifocal 

degeneration in the spinal 

cords of males.

Chronic LOAEL=0.5 

mg/kg/day based on axonal 

degeneration in the pons, 

medulla, and peripheral nerves 

(sciatic, sural, and tibial); 

whole body tremors; stiffness 

of the hind legs, spinal cord 

axonal degeneration, and 

muscle fiber degeneration.

Chronic Dietary 

(All

Populations)

NOAEL = 0.25 

mg/kg/day

UFA = 10x

UFH = 10x

FQPA SF = 

1x

Chronic RfD = 

0.0025 

mg/kg/day

Same as above.

Cancer (oral, 

dermal, 

inhalation)

Classification: “Not likely to be Carcinogenic to Humans” based on the absence of 

significant tumor increases in two adequate rodent carcinogenicity studies.
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1 Point of Departure (POD) = A data point or an estimated point that is derived from observed doseresponse data and used to mark the beginning of extrapolation to determine risk associated with lower

environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest 

observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from animal to human 

(interspecies). UFH = potential variation in sensitivity among members of the human population 

(intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). 

RfD = reference dose.

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure of 

the U.S. population and various population subgroups. The results reported in Tables 5

and 6 are for the general U.S. Population, all infants (<1 year old), children 1-2, children 

3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years.

 

Results of Acute Dietary (Food and Drinking Water) Exposure Analysis

The results of the acute dietary (food + drinking water) exposure analysis at the 95th, 99th, 

and 99.9th percentiles of exposure are reported in Table 5. The emamectin benzoate acute 

dietary risk estimates for food and drinking water using the ornamental scenario for 

drinking water are below HED’s level of concern (<100% aPAD) at the 99.9th percentile 

of exposure for the general U.S. population and all population subgroups (6.9% of the 

aPAD for the general U.S. population and 9.0% of the aPAD for females 13-49 years old, 

the most highly exposed subgroup).

Table 5. Results of Acute Dietary (Food and Drinking Water) Exposure Analysis Using DEEM FCID.

1

Population Subgroup aPAD 

(mg/kg/day)

95th Percentile 99th Percentile 99.9th Percentile

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

General U.S. Population 0.0025 0.000034 1.4 0.000085 3.4 0.000172 6.9

All Infants (< 1 year old) 0.000048 1.9 0.000084 3.4 0.000160 6.4

Children 1-2 years old 0.000048 1.9 0.000107 4.3 0.000187 7.5

Children 3-5 years old 0.000033 1.3 0.000076 3.0 0.000205 8.2

Children 6-12 years old 0.000022 0.88 0.000059 2.4 0.000101 4.0

Youth 13-19 years old 0.000014 0.56 0.000036 1.4 0.000132 5.3

Adults 20-49 years old 0.000034 1.4 0.000095 3.8 0.000186 7.5

Adults 50-99 years old 0.000040 1.6 0.000088 3.5 0.000176 7.0

Females 13-49 years old 0.000034 1.4 0.000097 3.9 0.000226 9.0

1

The population with the highest exposure is bolded.
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 12 of 29

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The results of the chronic dietary (food and drinking water) exposure analysis are 

reported in the summary table below. For the chronic dietary assessment, all population 

subgroups have risk estimates which are below HED’s level of concern. The emamectin

benzoate chronic dietary risk estimates for food and drinking water using the ornamental

scenario for drinking water are below HED’s level of concern for the general U.S. 

population and all population subgroups (<1% of the cPAD for the general U.S. 

population and <1% of the cPAD for all infants less than 1 year old and children 1-2 

years old, which are tied for the most highly exposed subgroup).

Table 6. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Emamectin 

Benzoate.

Population Subgroup

Acute Dietary

(99.9 Percentile) Chronic Dietary

Dietary Exposure 

(mg/kg/day) % aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

General U.S. Population 0.000172 6.9 0.000008 <1

All Infants (<1 year old)* 0.000160 6.4 0.000014 <1

Children 1-2 years old* 0.000187 7.5 0.000014 <1

Children 3-5 years old 0.000205 8.2 0.000010 <1

Children 6-12 years old 0.000101 4.0 0.000007 <1

Youth 13-19 years old 0.000132 5.3 0.000005 <1

Adults 20-49 years old 0.000186 7.5 0.000008 <1

Adults 50-99 years old 0.000176 7.0 0.000009 <1

Females 13-49 years old* 0.000226 9.0 0.000008 <1

*The subpopulations with the highest risk estimates are bolded.

VIII.Characterization of Inputs/Outputs

The acute and chronic assessments for food incorporate somewhat refined anticipated 

residue estimates for most commodities that were derived from field trial data and PCT

data. Monitoring data were used for apples in the acute assessment since apple juice had 

a significant impact on exposure. The use of more monitoring data and food preparationreduction factors for washing, cooking, etc. may have resulted in more refined estimates

of dietary exposure. More highly refined analyses are not needed at this time since the 

risk estimates are below HED’s level of concern.
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 13 of 29

IX. Conclusions

The acute dietary exposure assessment is a probabilistic assessment conducted for all 

proposed/registered food uses of emamectin benzoate and drinking water. The 

anticipated residue estimates used for most crops were based on field trial data, 

incorporated PCT estimates provided by BEAD, and processing factors where 

appropriate. PDP monitoring data were used for apples. A drinking water residue 

distribution based on the use on ornamentals was used in the acute assessment. The acute 

dietary exposure estimates for food and drinking water are below HED’s level of concern 

at the 99.9th percentile of exposure for all population subgroups (6.9% of the aPAD for 

the general U.S. population and 9.0% of the aPAD for females 13-49 years old).

The chronic dietary exposure assessment is a somewhat refined assessment conducted for 

all proposed/registered food uses of emamectin benzoate and drinking water. The 

anticipated residue estimates used for most crops were single point estimates (averages) 

based on field trial data, incorporated PCT estimates provided by BEAD, and processing 

factors where appropriate. An EDWC based on the use on ornamentals was used in the 

chronic assessment. The chronic dietary exposure estimates for food and drinking water 

are below HED’s level of concern for all population subgroups (<1% of the cPAD for the 

general U.S. population and <1% of the cPAD for all infants less than 1 year old and 

children 1-2 years old).

X. List of Attachments

Attachment 1: Acute Residue Distribution Files and Chronic Point Estimates.

Attachment 2: Percent Crop Treated Memos from BEAD.

Attachment 3: Acute Food plus Water Residue Input File.

Attachment 4: Acute Results File.

Attachment 5: Chronic Food plus Water Residue Input File.

Attachment 6: Chronic Results File.
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 14 of 29

Attachment 1: Acute Residue Distribution Files and Chronic Point Estimates

RDF 1

'Apple, PDP Data, 20%CT 

TOTALZ=1022

TOTALLOD=256

LODRES=0.0005

RDF 2

'Bell Pepper 

Field trial data 15%CT

TOTALZ=17

TOTALNZ=3

0.010

0.010

0.010

RDF 3

'Broccoli 

Field trial data 20%CT

TOTALZ=48

TOTALNZ=12

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.004

0.004

0.0064

0.0045

RDF 4

'Cabbage 

Field trial data 25%CT

TOTALZ=54

TOTALNZ=18

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.004

0.004

Chronic Apple Field Trial 

data; n = 30

Chronic= 0.010 x 0.05 

= 0.0005

Chronic= 0.003 x 0.05= 

0.00015

Chronic= 0.002 x 0.10= 

0.0002

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.009055

0.007055

Chronic= 0.0020 x 0.10= 

0.00020
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 15 of 29

RDF 5

‘Cauliflower 

Field trial data 20%CT

TOTALZ=48

TOTALNZ=12

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.004

RDF 6

'Celery 

Field trial data 40%CT

TOTALZ=32

TOTALNZ=21

0.008

0.008

0.006

0.006

0.006

0.006

0.004

0.004

0.002

0.0082

0.0069

0.0121

0.0104

0.0055

0.0062

0.0066

0.0048

0.0054

0.0083

0.0075

0.0044

RDF 7

'Lettuce-head

Field trial data 20%CT

TOTALZ=68

TOTALNZ=17

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.006

0.006

0.006

0.0065

0.004

0.0067

0.0063

RDF 8

'Lettuce-leaf 

Field trial data 20%CT

TOTALZ=80

TOTALNZ=20

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.012

0.012

0.014

0.014

0.0114

0.028

0.025

0.033

0.047

0.011

0.016

0.017

0.039

Chronic= 0.002 x 0.05= 

0.0001

Chronic= 0.0065 x 

0.20= 0.0013

Chronic= 0.0036 x 

0.10= 0.0004

Chronic= 0.017 x 0.10= 

0.0017
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 16 of 29

RDF 9

'Mustard greens 

Field trial data 100%CT

TOTALZ=0

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.013

0.013

0.013

0.013

0.014

0.016

0.1212

RDF 10

'Non-bell peppers 

Field trial data 15%CT

TOTALZ=68

TOTALNZ=12

0.010

0.010

0.010

0.010

0.010

0.010

0.010

0.010

0.010

0.010

0.010

0.010

RDF 11

'Pear 

Field trial data 20%CT

TOTALZ=64

TOTALNZ=16

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.008055

0.007055

0.007055

0.007055

RDF 12

'Spinach 

Field trial data 10%CT

TOTALZ=54

TOTALNZ=6

0.010

0.010

0.011

0.011

0.011

0.012

Chronic= 0.017 x 1= 0.02 Chronic= 0.010 x 

0.05= 0.0005

Chronic= 0.0030 x 

0.05= 0.00015

Chronic= 0.011 x 0.05= 

0.00055
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 17 of 29

RDF 13

‘Tomato Field trial data 

20%CT

TOTALZ=124

TOTALNZ=31

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.001556

0.003556

0.003556

0.003556

0.003556

0.003556

0.003556

0.005

0.005

RDF 14

‘Milk [apple 20%CT]

TOTALZ=80

20,0.0003

RDF 15

'Cattle fat [apple 

20%CT]

TOTALZ=80

20,0.003

RDF 16

'Cattle liver [apple 

20%CT]

TOTALZ=80

20,0.01

Chronic= 0.0022 x 0.10= 

0.0002

Chronic= 0.0003 x 

0.10 = 0.00003

Chronic= 0.003 x 0.10= 

0.0003

Chronic= 0.01 x 0.10= 

0.001
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 18 of 29

RDF 17

'Cattle meat [apple 

20%CT]

TOTALZ=80

20,0.002

RDF 18

'Cattle meat byproduct 

[apple 20%CT]

TOTALZ=80

20,0.01

RDF 19

'Hog fat [cotton 

2.5%CT]

TOTALZ=97

3,0.003

RDF 20

'Hog liver [cotton

2.5%CT]

TOTALZ=97

3,0.01

Chronic= 0.002 x 0.10= 

0.0002

Chronic= 0.01 x 0.10= 

0.001

Chronic = 0.003 x 0.01

= 0.00003

Chronic = 0.01 x 0.01 = 

0.0001

RDF 21

'Hog meat [cotton

2.5%CT]

TOTALZ=97

3,0.002

RDF 22

‘Hog meat bypd [cotton

2.5%CT]

TOTALZ=97

3,0.01

RDF 23

'Cream 

[apple 20%CT]

TOTALZ=80

20,0.002

RDF 24 

‘Cantaloupe

Field trial data 

100%CT

TOTALZ=0

0.0030

0.0030

0.0030

0.0030

0.0036

0.0040

0.0037

0.0032

0.0051

0.0037

Chronic = 0.002 x 0.01 

= 0.00002

Chronic = 0.01 x 0.01 = 

0.0001

Chronic = 0.002 x 0.10

= 0.0002

Chronic = 0.0035 x 0.40

= 0.0014

RDF 25

‘Cucumber

Field trial data 2.5%CT

TOTALZ=312

TOTALNZ=8

0.004

0.004

0.004

0.004

0.004

0.004

0.004

0.004

RDF 26

‘Summer Squash

Field trial data 100%CT

TOTALZ=0

0.0061

0.0061

0.0061

0.0061

0.0061

0.0061

0.0061

0.0061

RDF 27

‘Winter Squash Field 

Trial data 100%CT

TOTALZ=0

0.0061

0.0061

0.0061

0.0061

0.0061

0.0061

0.0061

0.0061

RDF 28

‘Watermelon

Cantaloupe field trial 

data 100%CT

TOTALZ=0

0.0030

0.0030

0.0030

0.0030

0.0036

0.0040

0.0037

0.0032

0.0051

0.0037

Chronic = 0.004 x 

0.025 = 0.0001

Chronic = 0.0061 x 

0.29 = 0.0018

Chronic = 0.0061 x 

0.29 = 0.0018

Chronic = 0.0035 x 0.19 

= 0.00066
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 19 of 29

RDF 29 

Almond

10%CT

TOTALZ=9454

6, 0.006

RDF 30

'Cattle kidney [apple 

20%CT]

TOTALZ=80

20, 0.0045

RDF 31

'Subgroup 9A Other

Cantaloupe Field Trial 

data 100%CT

TOTALZ=0

0.0030

0.0030

0.0030

0.0030

0.0036

0.0040

0.0037

0.0032

0.0051

0.0037

RDF 32

Ormamentals Drinking 

Water

Chronic = 0.006 x 0.05

= 0.0003

Chronic = 0.0045 x 

0.10 = 0.00045

Chronic = 0.0035 x 1 = 

0.0035

Chronic = 0.000150

RDF 33

Hog kidney [cotton 

2.5%CT]

TOTALZ=97

3, 0.0045

RDF 34

‘Brussels sprouts

40%CT

TOTALZ=6

TOTALNZ=4

0.004

0.004

0.004

0.004

RDF 35

Endive

Spinach FT 10%CT

TOTALZ=27

TOTALNZ=3

0.030

0.032

0.050

RDF 36 

Pistachio

Almond FT 2.5%CT

TOTALZ=234

TOTALNZ=6

0.006

0.006

0.006

0.006

0.006

0.006

Chronic = 0.0045 x 

0.01 = 0.000045

Chronic=0.004 x 

0.20=0.0008

Chronic0.037 x 

0.025=0.00092

Chronic = 0.006 x 0.025 

=0.00015

RDF 37 

Walnut

Pecan FT 2.5%CT

TOTALZ=234

TOTALNZ=6

0.006

0.006

0.006

0.006

0.006

0.006

Chronic = 0.006 x 

0.025 = 0.00015
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 20 of 29

Attachment 2: Percent Crop Treated Memos from BEAD

A screening level usage analysis (SLUA) dated 7/15/15 was provided by BEAD based on 

data years 2004-2013. The following data were excerpted from the 7/15/15 SLUA.

Screening Level Estimates of Agricultural Uses of Emamectin Benzoate (7/15/15) 

Crop Percent Crop Treated

Average Maximum

Almonds 5 10

Apples 10 20

Broccoli 5 20

Brussels sprouts 20 40

Cabbage 10 25

Cauliflower 5 20

Celery 20 40

Cotton <1 <2.5

Cucumbers <2.5 <2.5

Endive* <2.5 10

Lettuce 10 20

Pears 5 20

Peppers 5 15

Pistachios <2.5 <2.5

Spinach 5 10

Tomatoes 10 20

Walnuts <2.5 <2.5

* Chicory %CT was reported. Endive (Crop Group 4) can be grown from chicory. 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 21 of 29

Attachment 3: Acute Food plus Water Residue Input File

Filename: C:\Documents and Settings\NDODD\My Documents\DEEM Version 3.16\Emamectin 

benzoate 121515\EMAMECTINACUTEWine121515.R08

Chemical: Emamectin Benzoate

RfD(Chronic): .0025 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .0025 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 12-15-2015/13:01:17 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

 # Code 

----- ---- ------------ -------- -------- -------

 1 6 apple.rdf

 2 6 bellpepper.rdf

 3 6 broccoli.rdf

 4 6 cabbage.rdf

 5 6 cauliflower.rdf

 6 6 celery.rdf

 7 6 lettucehead.rdf

 8 6 lettuceleaf.rdf

 9 6 mustardgreen.rdf

 10 6 nonbellpepper.rdf

 11 6 pear.rdf

 12 6 spinach.rdf

 13 6 tomato.rdf

 14 6 milk.rdf

 15 6 cattlefat.rdf

 16 6 cattleliver.rdf

 17 6 cattlemeat.rdf

 18 6 cattlembypd.rdf

 19 6 hogfat.rdf

 20 6 hogliver.rdf

 21 6 hogmeat.rdf

 22 6 hogmeatbypd.rdf

 23 6 cream.RDF

 24 6 cantaloupe.rdf

 25 6 cucumber.rdf

 26 6 Summer squash.rdf

 27 6 Winter squash.rdf

 28 6 watermelon.rdf

 29 6 almond.rdf

 30 6 cattlekidney.rdf

 31 6 Subgroup 9A Other.rdf

 32 6 ornamentals DW.rdf

 33 6 hog kidney.rdf

 34 6 Brussels sprouts.rdf

 35 6 Endive.rdf

 36 6 Pistachio.rdf

 37 6 Walnut.rdf

 EPA Crop Commodity Name Def Res Adj.Factors RDLComment

 Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- -------

0401005000 4A Amaranth, leafy 0.012000 1.000 1.000 

0401018000 4A Arugula 0.012000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 0.012000 1.000 1.000 

0401133000 4A Cress, garden 0.012000 1.000 1.000 

0401134000 4A Cress, upland 0.012000 1.000 1.000 

0401138000 4A Dandelion, leaves 0.012000 1.000 1.000 

0401150000 4A Endive 0.012000 1.000 1.000 35 D32814

 Full comment: D328149, MRID 46587001

0401204000 4A Lettuce, head 0.006700 1.000 1.000 7 

0401205000 4A Lettuce, leaf 0.047000 1.000 1.000 8 

0401248000 4A Parsley, leaves 0.012000 1.000 1.000 

0401313000 4A Radicchio 0.006700 1.000 1.000 

0401355000 4A Spinach 0.012000 1.000 1.000 12 

0401355001 4A Spinach-babyfood 0.012000 1.000 1.000 12 

0402076000 4B Cardoon 0.012100 1.000 1.000 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 22 of 29

0402085000 4B Celery 0.012100 1.000 1.000 6 

0402085001 4B Celery-babyfood 0.012100 1.000 1.000 6 

0402086000 4B Celery, juice 0.012100 1.000 1.000 6 

0402087000 4B Celtuce 0.012100 1.000 1.000 

0402152000 4B Fennel, Florence 0.012100 1.000 1.000 

0402322000 4B Rhubarb 0.012100 1.000 1.000 

0402367000 4B Swiss chard 0.012100 1.000 1.000 

0501061000 5A Broccoli 0.006400 1.000 1.000 3 

0501061001 5A Broccoli-babyfood 0.006400 1.000 1.000 3 

0501062000 5A Broccoli, Chinese 0.006400 1.000 1.000 

0501064000 5A Brussels sprouts 0.004000 1.000 1.000 34 D39251

 Full comment: D392510, MRID 48539701

0501069000 5A Cabbage 0.004000 1.000 1.000 4 

0501071000 5A Cabbage, Chinese, napa 0.004000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 0.006400 1.000 1.000 

0501083000 5A Cauliflower 0.004000 1.000 1.000 5 

0501196000 5A Kohlrabi 0.004000 1.000 1.000 

0502063000 5B Broccoli raab 0.121200 1.000 1.000 9 

0502070000 5B Cabbage, Chinese, bok choy 0.121200 1.000 1.000 9 

0502117000 5B Collards 0.121200 1.000 1.000 9 

0502194000 5B Kale 0.121200 1.000 1.000 9 

0502229000 5B Mustard greens 0.121200 1.000 1.000 9 

0502318000 5B Rape greens 0.121200 1.000 1.000 9 

0502389000 5B Turnip, greens 0.121200 1.000 1.000 9 

0801374000 8A Tomatillo 0.005000 1.000 1.000 

0801375000 8A Tomato 0.005000 1.000 1.000 13 

0801375001 8A Tomato-babyfood 0.005000 1.000 1.000 13 

0801376000 8A Tomato, paste 0.002200 1.000 0.200 B; no 

 Full comment: B; no concentration (D328149)

0801376001 8A Tomato, paste-babyfood 0.002200 1.000 0.200 B

0801377000 8A Tomato, puree 0.002200 1.000 0.200 B; no 

 Full comment: B; no concentration (D328149)

0801377001 8A Tomato, puree-babyfood 0.002200 1.000 0.200 B

0801378000 8A Tomato, dried 0.002200 14.300 0.200 B

0801378001 8A Tomato, dried-babyfood 0.002200 14.300 0.200 B

0801379000 8A Tomato, juice 0.005000 1.500 1.000 13 

0801380000 8A Tomato, Tree 0.005000 1.000 1.000 

0802148000 8BC Eggplant 0.010000 1.000 1.000 

0802234000 8BC Okra 0.010000 1.000 1.000 

0802270000 8B Pepper, bell 0.010000 1.000 1.000 2 

0802270001 8B Pepper, bell-babyfood 0.010000 1.000 1.000 2 

0802271000 8B Pepper, bell, dried 0.010000 1.000 0.150 Blende

 Full comment: Blended (B)

0802271001 8B Pepper, bell, dried-babyfood 0.010000 1.000 0.150 B

0802272000 8BC Pepper, nonbell 0.010000 1.000 1.000 10 

0802272001 8BC Pepper, nonbell-babyfood 0.010000 1.000 1.000 10 

0802273000 8BC Pepper, nonbell, dried 0.010000 1.000 0.150 B

0901075000 9A Cantaloupe 0.005100 1.000 1.000 24 LOQ = 

 Full comment: LOQ = 0.001 x 6; used 1/2 LOQ for ND

0901187000 9A Honeydew melon 0.005100 1.000 1.000 31 

0901399000 9A Watermelon 0.005100 1.000 1.000 28 

0901400000 9A Watermelon, juice 0.005100 1.000 1.000 28 

0902021000 9B Balsam pear 0.004000 1.000 1.000 

0902088000 9B Chayote, fruit 0.006100 1.000 1.000 

0902102000 9B Chinese waxgourd 0.004000 1.000 1.000 

0902135000 9B Cucumber 0.004000 1.000 1.000 25 LOD = 

 Full comment: LOD = 0.004

0902308000 9B Pumpkin 0.006100 1.000 1.000 

0902309000 9B Pumpkin, seed 0.006100 1.000 1.000 B

0902356000 9B Squash, summer 0.006100 1.000 1.000 26 LOD = 

 Full comment: LOD = 0.0061

0902356001 9B Squash, summer-babyfood 0.006100 1.000 1.000 26 

0902357000 9B Squash, winter 0.006100 1.000 1.000 27 

0902357001 9B Squash, winter-babyfood 0.006100 1.000 1.000 27 

1100007000 11 Apple, fruit with peel 0.009055 1.000 1.000 1 

1100008000 11 Apple, peeled fruit 0.009055 1.000 1.000 1 

1100008001 11 Apple, peeled fruit-babyfood 0.009055 1.000 1.000 1 

1100009000 11 Apple, dried 0.002000 8.000 0.200 B

1100009001 11 Apple, dried-babyfood 0.002000 8.000 0.200 B

1100010000 11 Apple, juice 0.009055 1.000 1.000 1 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 23 of 29

1100010001 11 Apple, juice-babyfood 0.009055 1.000 1.000 1 

1100011000 11 Apple, sauce 0.009055 1.000 1.000 1 

1100011001 11 Apple, sauce-babyfood 0.009055 1.000 1.000 1 

1100129000 11 Crabapple 0.009055 1.000 1.000 

1100173500 11 Goji berry 0.005000 1.000 1.000 

1100210000 11 Loquat 0.008055 1.000 1.000 

1100266000 11 Pear 0.008055 1.000 1.000 11 

1100266001 11 Pear-babyfood 0.008055 1.000 1.000 11 

1100267000 11 Pear, dried 0.003000 6.250 0.200 B

1100268000 11 Pear, juice 0.008055 1.000 1.000 11 

1100268001 11 Pear, juice-babyfood 0.008055 1.000 1.000 11 

1100310000 11 Quince 0.008055 1.000 1.000 

1304179000 13D Grape, wine and sherry 0.050000 0.290 1.000 MRID 4

 Full comment: MRID 48758308

1400003000 14 Almond 0.020000 1.000 1.000 29 

1400003001 14 Almond-babyfood 0.020000 1.000 1.000 29 

1400004000 14 Almond, oil 0.020000 1.000 0.100 B

1400004001 14 Almond, oil-babyfood 0.020000 1.000 0.100 B

1400059000 14 Brazil nut 0.020000 1.000 1.000 

1400068000 14 Butternut 0.020000 1.000 1.000 

1400081000 14 Cashew 0.020000 1.000 1.000 

1400092000 14 Chestnut 0.020000 1.000 1.000 

1400155000 14 Hazelnut 0.020000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.020000 1.000 1.000 B

1400185000 14 Hickory nut 0.020000 1.000 1.000 

1400213000 14 Macadamia nut 0.020000 1.000 1.000 

1400269000 14 Pecan 0.020000 1.000 1.000 

1400278000 14 Pine nut 0.020000 1.000 1.000 

1400282000 14 Pistachio 0.020000 1.000 1.000 36 D32814

 Full comment: D328149, MRID 47243301

1400391000 14 Walnut 0.020000 1.000 1.000 37 D32814

 Full comment: D328149, MRID 47243301

2003128000 20C Cottonseed, oil 0.025000 1.000 0.025 B 

2003128001 20C Cottonseed, oil-babyfood 0.025000 1.000 0.025 B

3100044000 31 Beef, meat 0.002000 1.000 1.000 17 

3100044001 31 Beef, meat-babyfood 0.002000 1.000 1.000 17 

3100045000 31 Beef, meat, dried 0.002000 1.920 1.000 17 

3100046000 31 Beef, meat byproducts 0.010000 1.000 1.000 18 

3100046001 31 Beef, meat byproducts-babyfood 0.010000 1.000 1.000 18 

3100047000 31 Beef, fat 0.003000 1.000 1.000 15 

3100047001 31 Beef, fat-babyfood 0.003000 1.000 1.000 15 

3100048000 31 Beef, kidney 0.004500 1.000 1.000 30 

3100049000 31 Beef, liver 0.010000 1.000 1.000 16 

3100049001 31 Beef, liver-babyfood 0.010000 1.000 1.000 16 

3200169000 32 Goat, meat 0.002000 1.000 1.000 17 

3200170000 32 Goat, meat byproducts 0.010000 1.000 1.000 18 

3200171000 32 Goat, fat 0.003000 1.000 1.000 15 

3200172000 32 Goat, kidney 0.004500 1.000 1.000 30 

3200173000 32 Goat, liver 0.010000 1.000 1.000 16 

3300189000 33 Horse, meat 0.002000 1.000 1.000 17 

3400290000 34 Pork, meat 0.002000 1.000 1.000 21 

3400290001 34 Pork, meat-babyfood 0.002000 1.000 1.000 21 

3400291000 34 Pork, skin 0.010000 1.000 1.000 22 

3400292000 34 Pork, meat byproducts 0.010000 1.000 1.000 22 

3400292001 34 Pork, meat byproducts-babyfood 0.010000 1.000 1.000 22 

3400293000 34 Pork, fat 0.003000 1.000 1.000 19 

3400293001 34 Pork, fat-babyfood 0.003000 1.000 1.000 19 

3400294000 34 Pork, kidney 0.004500 1.000 1.000 33 

3400295000 34 Pork, liver 0.010000 1.000 1.000 20 

3500339000 35 Sheep, meat 0.002000 1.000 1.000 17 

3500339001 35 Sheep, meat-babyfood 0.002000 1.000 1.000 17 

3500340000 35 Sheep, meat byproducts 0.010000 1.000 1.000 18 

3500341000 35 Sheep, fat 0.003000 1.000 1.000 15 

3500341001 35 Sheep, fat-babyfood 0.003000 1.000 1.000 15 

3500342000 35 Sheep, kidney 0.004500 1.000 1.000 30 

3500343000 35 Sheep, liver 0.010000 1.000 1.000 16 

3600222000 36 Milk, fat 0.002000 1.000 1.000 23 

3600222001 36 Milk, fat-baby food/infant formu 0.002000 1.000 1.000 23 

3600223000 36 Milk, nonfat solids 0.000300 1.000 1.000 14 

3600223001 36 Milk, nonfat solids-baby food/in 0.000300 1.000 1.000 14 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 24 of 29

3600224000 36 Milk, water 0.000300 1.000 1.000 14 

3600224001 36 Milk, water-babyfood/infant form 0.000300 1.000 1.000 14 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.000300 1.000 1.000 14 

8601000000 86A Water, direct, all sources 0.000465 1.000 1.000 32 

8602000000 86B Water, indirect, all sources 0.000465 1.000 1.000 32 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 25 of 29

Attachment 4: Acute Results File

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for EMAMECTIN BENZOATE NHANES 2003-2008 2-Day

Residue file: EMAMECTINACUTEWine121515.R08 Adjustment factor #2 used.

Analysis Date: 12-15-2015/15:46:20 Residue file dated: 12-15-2015/13:01:17

RAC/FF intake summed over 24 hours

MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000034 1.35 0.000085 3.39 0.000172 6.89 

All Infants:

 0.000048 1.90 0.000084 3.36 0.000160 6.41 

Children 1-2:

 0.000048 1.92 0.000107 4.28 0.000187 7.49 

Children 3-5:

 0.000033 1.32 0.000076 3.05 0.000205 8.22 

Children 6-12:

 0.000022 0.88 0.000059 2.37 0.000101 4.04 

Youth 13-19:

 0.000014 0.56 0.000036 1.43 0.000132 5.29 

Adults 20-49:

 0.000034 1.35 0.000095 3.81 0.000186 7.46 

Adults 50-99:

 0.000040 1.60 0.000088 3.50 0.000176 7.02 

Female 13-49:

 0.000034 1.37 0.000097 3.87 0.000226 9.04 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for EMAMECTIN BENZOATE NHANES 2003-2008 2-Day

Residue file: EMAMECTINACUTEWine121515.R08 Adjustment factor #2 used.

Analysis Date: 12-15-2015/15:46:20 Residue file dated: 12-15-2015/13:01:17

RAC/FF intake summed over 24 hours

MC iterations = 1000; MC list in residue file; MC seed = 10; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--users:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.000034 1.35 0.000085 3.39 0.000172 6.89 

All Infants:

 0.000050 2.01 0.000087 3.46 0.000164 6.56 

Children 1-2:

 0.000048 1.92 0.000107 4.28 0.000187 7.50 

Children 3-5:

 0.000033 1.32 0.000076 3.05 0.000205 8.22 

Children 6-12:

 0.000022 0.88 0.000059 2.37 0.000101 4.05 

Youth 13-19:

 0.000014 0.56 0.000036 1.43 0.000132 5.29 

Adults 20-49:

 0.000034 1.35 0.000095 3.81 0.000186 7.46 

Adults 50-99:

 0.000040 1.60 0.000088 3.50 0.000176 7.02 

Female 13-49:

 0.000034 1.37 0.000097 3.87 0.000226 9.05 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 26 of 29

Attachment 5: Chronic Residue Input File

Filename: C:\Documents and Settings\NDODD\My Documents\DEEM Version 3.16\Emamectin 

benzoate 121515\EMAMECTINCHRONICWine121515.R08

Chemical: Emamectin Benzoate

RfD(Chronic): .0025 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .0025 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 12-16-2015/10:10:12 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0401005000 4A Amaranth, leafy 0.011000 1.000 1.000 

0401018000 4A Arugula 0.011000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 0.011000 1.000 1.000 

0401133000 4A Cress, garden 0.011000 1.000 1.000 

0401134000 4A Cress, upland 0.011000 1.000 1.000 

0401138000 4A Dandelion, leaves 0.011000 1.000 1.000 

0401150000 4A Endive 0.011000 1.000 0.025 

0401204000 4A Lettuce, head 0.003600 1.000 0.100 

0401205000 4A Lettuce, leaf 0.017000 1.000 0.100 

0401248000 4A Parsley, leaves 0.011000 1.000 1.000 

0401313000 4A Radicchio 0.003600 1.000 1.000 

0401355000 4A Spinach 0.011000 1.000 0.050 

0401355001 4A Spinach-babyfood 0.011000 1.000 0.050 

0402076000 4B Cardoon 0.006500 1.000 1.000 

0402085000 4B Celery 0.006500 1.000 0.200 

0402085001 4B Celery-babyfood 0.006500 1.000 0.200 

0402086000 4B Celery, juice 0.006500 1.000 0.200 

0402087000 4B Celtuce 0.006500 1.000 1.000 

0402152000 4B Fennel, Florence 0.006500 1.000 1.000 

0402322000 4B Rhubarb 0.006500 1.000 1.000 

0402367000 4B Swiss chard 0.006500 1.000 1.000 

0501061000 5A Broccoli 0.003000 1.000 0.050 

0501061001 5A Broccoli-babyfood 0.003000 1.000 0.050 

0501062000 5A Broccoli, Chinese 0.003000 1.000 1.000 

0501064000 5A Brussels sprouts 0.002000 1.000 0.200 

0501069000 5A Cabbage 0.002000 1.000 0.100 

0501071000 5A Cabbage, Chinese, napa 0.002000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 0.003000 1.000 1.000 

0501083000 5A Cauliflower 0.002000 1.000 0.050 

0501196000 5A Kohlrabi 0.002000 1.000 1.000 

0502063000 5B Broccoli raab 0.017000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 0.017000 1.000 1.000 

0502117000 5B Collards 0.017000 1.000 1.000 

0502194000 5B Kale 0.017000 1.000 1.000 

0502229000 5B Mustard greens 0.017000 1.000 1.000 

0502318000 5B Rape greens 0.017000 1.000 1.000 

0502389000 5B Turnip, greens 0.017000 1.000 1.000 

0801374000 8A Tomatillo 0.002200 1.000 1.000 

0801375000 8A Tomato 0.002200 1.000 0.100 

0801375001 8A Tomato-babyfood 0.002200 1.000 0.100 

0801376000 8A Tomato, paste 0.002200 1.000 0.100 

0801376001 8A Tomato, paste-babyfood 0.002200 1.000 0.100 

0801377000 8A Tomato, puree 0.002200 1.000 0.100 

0801377001 8A Tomato, puree-babyfood 0.002200 1.000 0.100 

0801378000 8A Tomato, dried 0.002200 14.300 0.100 

0801378001 8A Tomato, dried-babyfood 0.002200 14.300 0.100 

0801379000 8A Tomato, juice 0.002200 1.500 0.100 

0801380000 8A Tomato, Tree 0.002200 1.000 1.000 

0802148000 8BC Eggplant 0.010000 1.000 1.000 

0802234000 8BC Okra 0.010000 1.000 1.000 

0802270000 8B Pepper, bell 0.010000 1.000 0.050 

0802270001 8B Pepper, bell-babyfood 0.010000 1.000 0.050 

0802271000 8B Pepper, bell, dried 0.010000 1.000 0.050 

0802271001 8B Pepper, bell, dried-babyfood 0.010000 1.000 0.050 

0802272000 8BC Pepper, nonbell 0.010000 1.000 0.050 

0802272001 8BC Pepper, nonbell-babyfood 0.010000 1.000 0.050 

0802273000 8BC Pepper, nonbell, dried 0.010000 1.000 0.050 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 27 of 29

0901075000 9A Cantaloupe 0.003500 1.000 1.000 

0901187000 9A Honeydew melon 0.003500 1.000 1.000 

0901399000 9A Watermelon 0.003500 1.000 1.000 

0901400000 9A Watermelon, juice 0.003500 1.000 1.000 

0902021000 9B Balsam pear 0.004000 1.000 1.000 

0902088000 9B Chayote, fruit 0.006100 1.000 1.000 

0902102000 9B Chinese waxgourd 0.004000 1.000 1.000 

0902135000 9B Cucumber 0.004000 1.000 0.025 LOQ = 

 Full comment: LOQ = 0.02

0902308000 9B Pumpkin 0.006100 1.000 1.000 

0902309000 9B Pumpkin, seed 0.006100 1.000 1.000 

0902356000 9B Squash, summer 0.006100 1.000 1.000 LOQ = 

 Full comment: LOQ = 0.02

0902356001 9B Squash, summer-babyfood 0.006100 1.000 1.000 

0902357000 9B Squash, winter 0.006100 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.006100 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.002000 1.000 0.100 

1100008000 11 Apple, peeled fruit 0.002000 1.000 0.100 

1100008001 11 Apple, peeled fruit-babyfood 0.002000 1.000 0.100 

1100009000 11 Apple, dried 0.002000 8.000 0.100 

1100009001 11 Apple, dried-babyfood 0.002000 8.000 0.100 

1100010000 11 Apple, juice 0.002000 1.000 0.100 

1100010001 11 Apple, juice-babyfood 0.002000 1.000 0.100 

1100011000 11 Apple, sauce 0.002000 1.000 0.100 

1100011001 11 Apple, sauce-babyfood 0.002000 1.000 0.100 

1100129000 11 Crabapple 0.002000 1.000 1.000 

1100173500 11 Goji berry 0.002200 1.000 1.000 

1100210000 11 Loquat 0.003000 1.000 1.000 

1100266000 11 Pear 0.003000 1.000 0.050 

1100266001 11 Pear-babyfood 0.003000 1.000 0.050 

1100267000 11 Pear, dried 0.003000 6.250 0.050 

1100268000 11 Pear, juice 0.003000 1.000 0.050 

1100268001 11 Pear, juice-babyfood 0.003000 1.000 0.050 

1100310000 11 Quince 0.003000 1.000 1.000 

1304179000 13D Grape, wine and sherry 0.050000 0.290 1.000 MRID 4

 Full comment: MRID 48758308

1400003000 14 Almond 0.020000 1.000 0.050 

1400003001 14 Almond-babyfood 0.020000 1.000 0.050 

1400004000 14 Almond, oil 0.020000 1.000 0.050 

1400004001 14 Almond, oil-babyfood 0.020000 1.000 0.050 

1400059000 14 Brazil nut 0.020000 1.000 1.000 

1400068000 14 Butternut 0.020000 1.000 1.000 

1400081000 14 Cashew 0.020000 1.000 1.000 

1400092000 14 Chestnut 0.020000 1.000 1.000 

1400155000 14 Hazelnut 0.020000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.020000 1.000 1.000 

1400185000 14 Hickory nut 0.020000 1.000 1.000 

1400213000 14 Macadamia nut 0.020000 1.000 1.000 

1400269000 14 Pecan 0.020000 1.000 1.000 

1400278000 14 Pine nut 0.020000 1.000 1.000 

1400282000 14 Pistachio 0.020000 1.000 0.025 

1400391000 14 Walnut 0.020000 1.000 0.025 

2003128000 20C Cottonseed, oil 0.025000 1.000 0.010 

2003128001 20C Cottonseed, oil-babyfood 0.025000 1.000 0.010 

3100044000 31 Beef, meat 0.002000 1.000 0.100 

3100044001 31 Beef, meat-babyfood 0.002000 1.000 0.100 

3100045000 31 Beef, meat, dried 0.002000 1.920 0.100 

3100046000 31 Beef, meat byproducts 0.010000 1.000 0.100 

3100046001 31 Beef, meat byproducts-babyfood 0.010000 1.000 0.100 

3100047000 31 Beef, fat 0.003000 1.000 0.100 

3100047001 31 Beef, fat-babyfood 0.003000 1.000 0.100 

3100048000 31 Beef, kidney 0.004500 1.000 0.100 

3100049000 31 Beef, liver 0.010000 1.000 0.100 

3100049001 31 Beef, liver-babyfood 0.010000 1.000 0.100 

3200169000 32 Goat, meat 0.002000 1.000 0.100 

3200170000 32 Goat, meat byproducts 0.010000 1.000 0.100 

3200171000 32 Goat, fat 0.003000 1.000 0.100 

3200172000 32 Goat, kidney 0.004500 1.000 0.100 

3200173000 32 Goat, liver 0.010000 1.000 0.100 

3300189000 33 Horse, meat 0.002000 1.000 0.100 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 28 of 29

3400290000 34 Pork, meat 0.002000 1.000 0.010 

3400290001 34 Pork, meat-babyfood 0.002000 1.000 0.010 

3400291000 34 Pork, skin 0.010000 1.000 0.010 

3400292000 34 Pork, meat byproducts 0.010000 1.000 0.010 

3400292001 34 Pork, meat byproducts-babyfood 0.010000 1.000 0.010 

3400293000 34 Pork, fat 0.003000 1.000 0.010 

3400293001 34 Pork, fat-babyfood 0.003000 1.000 0.010 

3400294000 34 Pork, kidney 0.004500 1.000 0.010 

3400295000 34 Pork, liver 0.010000 1.000 0.010 

3500339000 35 Sheep, meat 0.002000 1.000 0.100 

3500339001 35 Sheep, meat-babyfood 0.002000 1.000 0.100 

3500340000 35 Sheep, meat byproducts 0.010000 1.000 0.100 

3500341000 35 Sheep, fat 0.003000 1.000 0.100 

3500341001 35 Sheep, fat-babyfood 0.003000 1.000 0.100 

3500342000 35 Sheep, kidney 0.004500 1.000 0.100 

3500343000 35 Sheep, liver 0.010000 1.000 0.100 

3600222000 36 Milk, fat 0.002000 1.000 0.100 

3600222001 36 Milk, fat-baby food/infant formu 0.002000 1.000 0.100 

3600223000 36 Milk, nonfat solids 0.000300 1.000 0.100 

3600223001 36 Milk, nonfat solids-baby food/in 0.000300 1.000 0.100 

3600224000 36 Milk, water 0.000300 1.000 0.100 

3600224001 36 Milk, water-babyfood/infant form 0.000300 1.000 0.100 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.000300 1.000 0.100 

8601000000 86A Water, direct, all sources 0.000150 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.000150 1.000 1.000 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D430736

PC Code: 122806

______________________________________________________________________________________

Page 29 of 29

Attachment 6: Chronic Results File

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for EMAMECTIN BENZOATE NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\NDODD\My Documents\DEEM Version 

3.16\Emamectin benzoate 121515\EMAMECTINCHRONICWine121515.R08

 Adjustment factor #2 used.

Analysis Date 12-16-2015/10:25:49 Residue file dated: 12-16-2015/10:10:12

Reference dose (RfD, Chronic) = .0025 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.000008 0.3%

Hispanic 0.000007 0.3%

Non-Hisp-White 0.000009 0.4%

Non-Hisp-Black 0.000007 0.3%

Non-Hisp-Other 0.000009 0.4%

Nursing Infants 0.000008 0.3%

Non-Nursing Infants 0.000017 0.7%

Female 13+ PREG 0.000006 0.2%

Children 1-6 0.000011 0.4%

Children 7-12 0.000006 0.3%

Male 13-19 0.000005 0.2%

Female 13-19/NP 0.000004 0.2%

Male 20+ 0.000008 0.3%

Female 20+/NP 0.000010 0.4%

Seniors 55+ 0.000010 0.4%

All Infants 0.000014 0.6%

Female 13-50 0.000008 0.3%

Children 1-2 0.000014 0.5%

Children 3-5 0.000010 0.4%

Children 6-12 0.000007 0.3%

Youth 13-19 0.000005 0.2%

Adults 20-49 0.000008 0.3%

Adults 50-99 0.000009 0.4%

Female 13-49 0.000008 0.3%

-------------------------------------------------------------------------------