49878 Federal Register / Vol. 74, No. 187 / Tuesday, September 29, 2009 / Notices 

October 1, 1995, unless it displays a 

currently valid OMB control number. 

5 CFR 1320.5: Reporting and 

Recordkeeping Requirements: Final 

Rule: Respondents to this collection of 

information are not required to respond 

unless the data collection instruments 

display a currently valid OMB control 

number. 

Proposed Collection: Title: The Sister 

Study PHASE 2: Environmental and 

Genetic Risk Factors for Breast Cancer. 

Type of Information Collection Request: 

Revision of OMB No. 0925–0522 and 

expiration date 30 September 2009. 

Need and Use of Information Collection: 

The purpose of the Sister Study is to 

study genetic and environmental risk 

factors for the development of breast 

cancer in a high-risk cohort of sisters of 

women who have had breast cancer. In 

the United States, approximately 

192,370 new cases of invasive breast 

cancer are anticipated in 2009. The 

etiology of breast cancer is complex, 

with both genetic and environmental 

factors likely playing a role. 

Environmental risk factors, however, 

have been difficult to identify. By 

focusing on genetically susceptible 

subgroups, more precise estimates of the 

contribution of environmental and other 

non-genetic factors to disease risk may 

be possible. Sisters of women with 

breast cancer are one group at increased 

risk for breast cancer; we would expect 

at least 2 times as many breast cancers 

to accrue in a cohort of sisters as would 

accrue in a cohort identified through 

random sampling or other means. In 

addition, a cohort of sisters should be 

enriched with regard to the prevalence 

of relevant genes and/or exposures, 

further enhancing the ability to detect 

gene-environment interactions. Sisters 

of women with breast cancer will also 

be at increased risk for ovarian cancer 

and possibly for other hormonallymediated diseases. We have enrolled a 

cohort of 50,000 women who have not 

had breast cancer. Recruitment took 

place from August 2003 through July 

2009. We estimate that in the cohort of 

50,000 sisters, aged 35–74 at enrollment, 

approximately 300 new cases of breast 

cancer will be diagnosed during each 

year of follow-up. Frequency of 

Response: For the remainder of the 

study, women will be contacted once 

each year to update contact information 

and health status (5–10 minutes per 

response); and asked to complete short 

(60–75 minutes, total) updates every 

two-to-three years. Women diagnosed 

with breast cancer or other health 

outcomes of interest are asked to 

provide additional information about 

their diagnosis (20 minutes per 

response) and their doctors will be 

contacted to provide medical records 

related to diagnosis and treatments (15 

minutes per response). Affected Public: 

Study participants; medical office staff. 

Type of Respondents: Participants 

enrolled in high-risk cohort study of risk 

factors for breast cancer. The annual 

reporting burden is as follows: 

Estimated Number of Respondents: 

50,000 study participants and 2100 

medical office staff. Estimated Number 

of Responses per Respondent: See table 

below: 

Activity (3-yrs) 

Estimated 

number of 

respondents 

Estimated 

responses per 

respondent 

Average 

burden hours 

per response 

Estimated total 

burden hours 

requested 

Annual Updates ............................................................................................... 50,000 2 0.085 8,500 

Bi/Trienniel Follow-Up ...................................................................................... 50,000 1 1.25 62,500 

Incident BC Case Follow-Up ........................................................................... 1800 1 0.33 594 

Incident Other Case Follow-Up ....................................................................... 300 1 0.33 99 

Incident Case Medical Office Contact ............................................................. 2100 1 0.25 525 

Total .......................................................................................................... ........................ ........................ ........................ 72,218 

Average Burden Hours Per Response: 

0.7 hour; and Estimated Total Burden 

Hours Requested: 72,218 (over 3 years). 

The average annual burden hours 

requested is 24,073. The annualized cost 

to respondents is estimated at $14 

(assuming $20 hourly wage × 0.7 hour). 

There are no Capital Costs to report. 

There are no Operating or Maintenance 

Costs to report. 

Request for Comments: Written 

comments and/or suggestions from the 

public and affected agencies should 

address one or more of the following 

points: (1) Evaluate whether the 

proposed collection of information is 

necessary for the proper performance of 

the function of the agency, including 

whether the information will have 

practical utility; (2) Evaluate the 

accuracy of the agency’s estimate of the 

burden of the proposed collection of 

information, including the validity of 

the methodology and assumptions used; 

(3) Enhance the quality, utility, and 

clarity of the information to be 

collected; and (4) Minimize the burden 

of the collection of information on those 

who are to respond, including the use 

of appropriate automated, electronic, 

mechanical, or other technological 

collection techniques or other forms of 

information technology. 

Direct Comments to OMB: Written 

comments and/or suggestions regarding 

the item(s) contained in this notice, 

especially regarding the estimated 

public burden and associated response 

time, should be directed to the: Office 

of Management and Budget, Office of 

Regulatory Affairs, 

OIRA_submission@omb.eop.gov or by 

fax to 202–395–6974, Attention: Desk 

Officer for NIH. To request more 

information on the proposed project or 

to obtain a copy of the data collection 

plans and instruments, contact: Dr. Dale 

P. Sandler, Chief, Epidemiology Branch, 

NIEHS, Rall Building A3–05, PO Box 

12233, Research Triangle Park, NC 

27709 or call non-toll-free number (919) 

541–4668 or E-mail your request, 

including your address to: 

‘‘sandler@niehs.nih.gov.’’ 

Comments Due Date: Comments 

regarding this information collection are 

best assured of having their full effect if 

received within 30-days of the date of 

this publication. 

Dated: September 22, 2009. 

Marc Hollander, 

NIEHS, Associate Director for Management. 

[FR Doc. E9–23510 Filed 9–28–09; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Center for Scientific Review; Notice of 

Closed Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meetings. 

The meetings will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 


jlentini on DSKJ8SOYB1PROD with NOTICES
Federal Register / Vol. 74, No. 187 / Tuesday, September 29, 2009 / Notices 49879 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: Immunology 

Integrated Review Group, Innate Immunity 

and Inflammation Study Section. 

Date: October 15–16, 2009. 

Time: 8 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Key Bridge Marriott, 1401 Lee 

Highway, Arlington, VA 22209. 

Contact Person: Tina McIntyre, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 4202, 

MSC 7812, Bethesda, MD 20892, 301–594– 

6375, mcintyrt@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel, Member 

Conflict. 

Date: October 15, 2009. 

Time: 1 p.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892. 

(Virtual Meeting) 

Contact Person: Jose Fernando Arena, PhD, 

MD, Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 3135, 

MSC 7770, Bethesda, MD 20892, 301–435– 

1735, arenaj@mail.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel, 

Microcirculation, Hypertension and 

Atherosclerosis. 

Date: October 20–21, 2009. 

Time: 11 a.m. to 9 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892. 

(Virtual Meeting) 

Contact Person: Anshumali Chaudhari, 

PhD, Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 4124, 

MSC 7802, Bethesda, MD 20892, (301) 435– 

1210, chaudhaa@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel, 

Investigations on Primary Immunodeficiency 

Diseases. 

Date: October 20, 2009. 

Time: 11 a.m. to 3 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892. 

(Virtual Meeting) 

Contact Person: Jin Huang, PhD, Scientific 

Review Officer, Center for Scientific Review, 

National Institutes of Health, 6701 Rockledge 

Drive, Room 4095G, MSC 7812, Bethesda, 

MD 20892, 301–435–1230, jh377p@nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel, Eukaryotic 

Pathogens and Their Vectors. 

Date: October 20, 2009. 

Time: 3:30 p.m. to 5:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892. 

(Telephone Conference Call) 

Contact Person: Richard G. Kostriken, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 3192, 

MSC, 7808 Bethesda, MD 20892, 301–402– 

4454, kostrikr@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel, PARO8– 

224: System Dynamics Methodologies. 

Date: October 26, 2009. 

Time: 11 a.m. to 12:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892. 

(Virtual Meeting) 

Contact Person: Fungai Chanetsa, MPH, 

PhD, Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 3135, 

MSC 7770, Bethesda, MD 20892, 301–435– 

1262, fungai.chanetsa@nih.hhs.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel, Member 

Conflict: Cell Death and Neurodegeneration. 

Date: October 26, 2009. 

Time: 12 p.m. to 3 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892. 

(Telephone Conference Call) 

Contact Person: Alexander Yakovlev, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 5206, 

MSC 7846, Bethesda, MD 20892, 301–435– 

1254, yakovleva@csr.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.306, Comparative Medicine; 

93.333, Clinical Research, 93.306, 93.333, 

93.337, 93.393–93.396, 93.837–93.844, 

93.846–93.878, 93.892, 93.893, National 

Institutes of Health, HHS) 

Dated: September 22, 2009. 

Jennifer Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. E9–23336 Filed 9–28–09; 8:45 am] 

BILLING CODE 4140–01–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Center for Scientific Review; Notice of 

Closed Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meetings. 

The meetings will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel, 

Reproductive Sciences and Development. 

Date: October 14–15, 2009. 

Time: 10 a.m. to 1 p.m. 

Agenda: To review and evaluate grant 

Applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892. 

(Virtual Meeting) 

Contact Person: Krish Krishnan, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 6164, 

MSC 7892, Bethesda, MD 20892, (301) 435– 

1041, krishnak@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel, Mental 

Health and Neurodegenerative Disorders 

Members. Conflict. 

Date: October 26–27, 2009. 

Time: 8 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892. 

(Virtual Meeting) 

Contact Person: Suzan Nadi, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 521 7B, 

MSC 7846, Bethesda, MD 20892, 301–435– 

1259, nadis@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel, Member 

Conflicts: Hepatobiliary Pathophysiology, 

Toxicology and Pharmacology. 

Date: October 26–27, 2009. 

Time: 8 a.m. to 6 p.m. 

Agenda: To review and evaluate grant 

Applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892. 

(Virtual Meeting) 

Contact Person: Bonnie L. Burgess-Beusse, 

PhD, Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 2182, 

MSC 7818, Bethesda, MD 20892, 301–435– 

1783, beusseb@mail.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel Ethical, 

Legal and Societal Implications of Genetics. 

Date: October 29, 2009. 

Time: 2 p.m. to 4:30 p.m. 

Agenda: To review and evaluate grant 

Applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892. 

(Telephone Conference Call) 

Contact Person: Diane L. Stassi, PhD, 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 2200, 


jlentini on DSKJ8SOYB1PROD with NOTICES