Exhibit 4.5


 


ADS WARRANT AGENT
AGREEMENT


 


ADS WARRANT AGENT AGREEMENT (this “Warrant
Agreement”) dated as of _________, 2015 (the “Issuance Date”) between BiondVax Pharmaceuticals Ltd.,
a company incorporated under the laws of the State of Israel (the “Company”), and The Bank of New York Mellon
(the “Warrant Agent”).


 


WHEREAS, the Company is engaged in a public
offering (the “Offering”) of an aggregate of _________ American Depositary Shares (“ADSs”), each
representing forty (40) ordinary shares, par value NIS 0.0000001 per share, of the Company (“Ordinary Shares”),
and __________ Warrants (the “Warrants”), with each such Warrant representing the right of the holder thereof
to purchase one ADS (each, a “Warrant ADS”) for $___, subject to adjustment as described herein, plus applicable
fees, charges and taxes;


 


WHEREAS, the ADSs are issuable under the
Deposit Agreement dated as of ______, 2015 (the “Deposit Agreement”) among the Company, The Bank of New York
Mellon, as depositary (the “Depositary”) and all Owners and Holders (each as defined in the Deposit Agreement) from
to time of the ADSs issued thereunder;


 


WHEREAS, the Company has filed with the
Securities and Exchange Commission a Registration Statement, No. 333-201283 on Form F-1 (as the same may be amended from time to
time, the “Registration Statement”) for the registration, under the Securities Act of 1933, as amended (the “Act”)
of, among other securities, the Warrants and the Ordinary Shares represented by the Warrant ADSs (the “Warrant Shares”),
and such Registration Statement was declared effective on ________, 2015;


 


WHEREAS, the Company desires the Warrant
Agent to act on behalf of the Company, and the Warrant Agent is willing to so act, in connection with the issuance, registration,
transfer, exchange and exercise of the Warrants;


 


WHEREAS, the Company desires to provide
for the provisions of the Warrants, the terms upon which they shall be issued and exercised, and the respective rights, limitation
of rights, and immunities of the Company, the Warrant Agent, and the holders of the Warrants; and


 


WHEREAS, all acts and things have been
done and performed which are necessary to make the Warrants the valid, binding and legal obligations of the Company, and to authorize
the execution and delivery of this Agreement.


 


NOW, THEREFORE, in consideration of the
mutual agreements herein contained, the parties hereto agree as follows:


 


1. Appointment of Warrant Agent.
The Company hereby appoints the Warrant Agent to act as agent for the Company with respect to the Warrants, and the Warrant Agent
hereby accepts such appointment and agrees to perform the same in accordance with the express terms and conditions set forth in
this Warrant Agreement (and no implied terms or conditions).


 


2. Warrants.


 


2.1 Form of Warrant. The Warrants
shall be registered securities and shall be evidenced by certificates “Warrant Certificates” in the form of Annex
A to this Warrant Agreement.


 


2.2. Issuance and Registration of Warrants.


 


2.2.1. Warrant Register. The Warrant
Agent shall maintain books (“Warrant Register”), for the registration of original issuance and the registration of
transfer of the Warrants.


 



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2.2.2. Issuance of Warrants. Upon
the initial issuance of the Warrants, the Warrant Agent shall issue and register the Warrants in the names of the respective holders
thereof (“Holders”) in such denominations and otherwise in accordance with written instructions delivered to
the Warrant Agent by the Company. Initially, all of the Warrants shall be represented by one or more global Warrant Certificates
registered in the name of Cede & Co., a nominee of The Depository Trust Company (“DTC”). Ownership of security
entitlements in the Warrants held at DTC shall be shown on, and the transfer of such ownership shall be effected through, records
maintained (i) by DTC and (ii) by institutions that have accounts with DTC (each, a “Participant”). Prior to due presentment
for registration of transfer of any Warrant, the Company and the Warrant Agent may deem and treat the Holder as the absolute owner
of such Warrant, for the purpose of any exercise thereof, and for all other purposes, and neither the Company nor the Warrant Agent
shall be affected by any notice to the contrary. The Warrant Certificates shall be executed on behalf of the Company by any authorized
officer of the Company (an “Authorized Officer”), which need not be the same authorized signatory for all of
the Warrant Certificates, either manually or by facsimile signature. The Warrant Certificates shall be countersigned by an authorized
signatory of the Warrant Agent, which need not be the same signatory for all of the Warrant Certificates, and no Warrant Certificate
shall be valid for any purpose unless so countersigned. In case any Authorized Officer of the Company that signed any of the Warrant
Certificates ceases to be an Authorized Officer of the Company before countersignature by the Warrant Agent and issuance and delivery
by the Company, such Warrant Certificates, nevertheless, may be countersigned by the Warrant Agent, issued and delivered with the
same force and effect as though the person who signed such Warrant Certificates had not ceased to be such officer of the Company;
and any Warrant Certificate may be signed on behalf of the Company by any person who, at the actual date of the execution of such
Warrant Certificate, shall be an Authorized Officer of the Company authorized to sign such Warrant Certificate, although at the
date of the execution of this Warrant Agreement any such person was not such an Authorized Officer.


 


2.2.3. Registration of Transfer.
At any time at or prior to the Expiration Date (as defined below), a transfer of any Warrants may be registered and any Warrant
Certificate or Warrant Certificates may be split up, combined or exchanged for another Warrant Certificate or Warrant Certificates
evidencing the same number of Warrants as the Warrant Certificate or Warrant Certificates surrendered. Any Holder desiring to register
the transfer of Warrants or to split up, combine or exchange any Warrant Certificate shall make such request in writing delivered
to the Warrant Agent, and shall surrender to the Warrant Agent the Warrant Certificate or Warrant Certificates evidencing the Warrants
the transfer of which is to be registered or that is or are to be split up, combined or exchanged and, in the case of registration
of transfer, shall provide a signature guarantee. Thereupon, the Warrant Agent shall countersign and deliver to the person entitled
thereto a Warrant Certificate or Warrant Certificates, as the case may be, as so requested. The Company and the Warrant Agent may
require payment, by the holder of Warrant requesting a registration of transfer of Warrants or a split-up, combination or exchange
of a Warrant Certificate, of a sum sufficient to cover any tax or governmental charge that may be imposed in connection with such
registration of transfer, split-up, combination or exchange, together with reimbursement to the Company and the Warrant Agent of
all reasonable expenses incidental thereto.


 


2.2.4. Loss, Theft and Mutilation of
Warrant Certificates. Upon receipt by the Company and the Warrant Agent of evidence reasonably satisfactory to them of the
loss, theft, destruction or mutilation of an Warrant Certificate, and, in case of loss, theft or destruction, of indemnity or security
in customary form and amount, and reimbursement to the Company and the Warrant Agent of all reasonable expenses incidental thereto,
and upon surrender to the Warrant Agent and cancellation of the Warrant Certificate if mutilated, the Agent shall, on behalf of
the Company, countersign and deliver a new Warrant Certificate of like tenor to the Holder in lieu of the Warrant Certificate so
lost, stolen, destroyed or mutilated. The Warrant Agent may charge the Holder an administrative fee for processing the replacement
of lost Warrant Certificates, which shall be charged only once in instances where a single surety bond obtained covers multiple
certificates. The Warrant Agent may receive compensation from the surety companies or surety agents for administrative services
provided to them.


 


3. Terms and Exercise of Warrants.


 


3.1. Exercise Price. Each Warrant
shall entitle the registered holder thereof, subject to the provisions of the Warrant Certificate and of this Warrant Agreement,
to purchase from the Company the number of ADSs stated therein, at the price of $_____ per whole ADS, subject to the subsequent
adjustments provided in Section 4 hereof. The term “Exercise Price” as used in this Warrant Agreement refers
to the price per ADS at which ADSs may be purchased at the time a Warrant is exercised. In addition to the Exercise Price, an exercising
Holder must pay to the Warrant Agent at the time of exercise the Depositary’s fee of $.05 per ADS for issuance of ADSs (the
“Issuance Fee”). The Exercise Price per ADS plus the Issuance Fee per ADS is referred to as the “Deposit
Amount”.


 



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3.2. Duration of Warrants. A Warrant
may be exercised only during the period (“Exercise Period”) commencing on the Issuance Date and terminating
at 5:00 P.M., New York City time (the “close of business”) on ________, 2019 (“Expiration Date”).
Each Warrant not exercised on or before the Expiration Date shall become void, and all rights thereunder and all rights in respect
thereof under this Warrant Agreement shall cease at the close of business on the Expiration Date.


 


3.3. Exercise of Warrants.


 


3.3.1. Exercise and Payment. Subject
to the provisions of this Warrant Agreement, a Holder (or a Participant acting on behalf of a Holder in accordance with DTC procedures)
may exercise a Warrant by delivering, not later than 5:00 P.M., New York time, on any business day during the Exercise Period (the
“Exercise Date”) to the Warrant Agent at its office designated for such purpose, (i) the Warrants to be exercised by
(A) surrender of the Warrant Certificate evidencing the Warrant or (B) delivery of the Warrant to an account of the Warrant Agent
at DTC designated for such purpose in writing by the Warrant Agent to DTC from time to time, (ii) an election to purchase the Warrant
ADSs underlying the Warrants to be exercised in form of Annex B to this Warrant Agreement (“Election to Purchase”)
and (iii) the Deposit Amount for each Warrant to be exercised, and all applicable taxes and charges due in connection with the
exercise of such Warrants, in lawful money of the United States of America by (A) certified or official bank check payable to The
Bank of New York Mellon, (B) by bank wire transfer in immediately available funds to The Bank of New York Mellon , 500 Ross Street,
Pittsburgh, PA 15262-00001, ABA #: 043-000-261, Account Number: 1361721, Account Name: Computershare Inc. AAF Client Corporate
Actions, Ref: Biondvax Warrants, Swift Code MELNUS3P or (C) payment to the Warrant Agent through the DTC system.


 


If any of (A) the Warrants, (B) the Election
to Purchase, or (C) the Deposit Amount therefor, and all applicable taxes and charges due in connection therewith, is received
by the Warrant Agent after 5:00 P.M., New York time, on any date, or on a date that is not a business day, the Warrants with respect
thereto will be deemed to have been received and exercised on the business day next succeeding such date. The “Exercise
Date” will be the date the materials in the foregoing sentence are received by the Warrant Agent (if by 5:00 P.M., New
York time), or the following business day (if after 5:00 P.M., New York time), regardless of any earlier date written on the materials.
If the Warrants are received or deemed to be received after the Expiration Date, the exercise thereof will be null and void and
any funds delivered to the Warrant Agent will be returned to the registered holder or Participant, as the case may be, as soon
as practicable. In no event will interest accrue on any funds deposited with the Warrant Agent in respect of an exercise or attempted
exercise of Warrants. The validity of any exercise of Warrants will be determined by the Company in its sole discretion and such
determination will be final and binding upon the Holder or Participant and the Warrant Agent. Neither the Company nor the Warrant
Agent shall have any obligation to inform a Holder or the Participant, as applicable, of the invalidity of any exercise of Warrants.


 


The Warrant Agent shall deposit all funds
received by it in payment of the Exercise Price in the account of the Company maintained with the Warrant Agent for such purpose
and shall advise the Company via telephone at the end of each day on which funds for the exercise of the Warrants are received
of the amount so deposited to its account. The Warrant Agent shall promptly confirm such telephonic advice to the Company in writing.


 


If less than all the Warrants evidenced
by a surrendered Warrant Certificate are exercised, the Warrant Agent shall split up the surrendered Warrant Certificate and return
to the Holder a Warrant Certificate evidencing the Warrants that were not exercised.


 


3.3.2. Issuance of Warrant Shares.
The Warrant Agent shall, by 11:00 A.M. New York Time on the business day following the Exercise Date of any Warrant, advise the
Company, the transfer agent and registrar for Ordinary Shares and the Depositary, in respect of (a) the number of Warrant Shares
indicated on the Election to Purchase as issuable upon such exercise with respect to such exercised Warrants, (b) the instructions
of the Holder or Participant, as the case may be, provided to the Warrant Agent with respect to the delivery of the Warrant ADSs
notation that shall be made to the records maintained by the Depository, its nominee for each Warrant, or a Participant, as appropriate,
evidencing the balance, if any, of the Warrants remaining after such exercise and (c) such other information as the Company or
the Depositary shall reasonably request. The Warrant Agent shall pay the Depositary the Issuance Fee for the number of Warrant
ADSs to be issued out of the Deposit Amount it received.


 



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The Company shall, by 5:00 P.M., New York
time, on the third business day next succeeding the Exercise Date of any Warrant and the clearance of the funds in payment of the
Exercise Price, use its reasonable best efforts to cause its transfer agent to electronically transmit the Warrant Shares issuable
upon exercise to the Depositary’s Israeli custodian for deposit under the Deposit Agreement and instruct the Depositary to
deliver the Warrant ADSs issuable upon that deposit as requested in the Election to Purchase. The time periods for delivery described
in the immediately preceding paragraph shall apply to the electronic transmittals described herein.


 


3.3.3. Valid Issuance. All Warrant
Shares issuable by the Company upon the proper exercise of a Warrant in conformity with this Warrant Agreement shall be validly
issued, fully paid and non-assessable.


 


3.3.4. No Fractional Exercise.
No fractional Warrant ADSs will be issued upon the exercise of the Warrant, but rather the Company shall adjust the number of Warrant
Shares issued up or down to the nearest integral multiple of the number of Ordinary Shares at the time represented by one ADS.


 


3.3.5 No Transfer Taxes. The Company
shall not be required to pay any stamp or other tax or charge required to be paid in connection with any transfer involved in the
issue of the Warrant Shares upon the exercise of Warrants; and in the event that any such transfer is involved, the Company shall
not be required to issue or deliver any Warrant Shares until such tax or other charge shall have been paid or it has been established
to the Company’s and the Warrant Agent’s satisfaction that no such tax or other charge is due.


 


3.3.6 Date of Issuance. The Company
will, to the extent practical, treat an exercising Holder as a beneficial owner of the Warrant Shares as of the Exercise Date,
except that, if the Exercise Date is a date when the stock transfer books of the Company are closed, such person shall be deemed
to have become the holder of such shares at the close of business on the next succeeding date on which the stock transfer books
are open. However, it is understood and agreed that Warrant ADSs will not be registered or issued until the Depositary receives
notice from its custodian that the Warrant Shares have been deposited under the Deposit Agreement.


 


3.3.7 Cashless Exercise Under Certain
Circumstances.


 


(i) The Company shall provide to the Warrant
Agent and each Holder prompt written notice of any time that the Company is unable to deliver the Warrant ADSs via DTC transfer
or otherwise (without restrictive legend), because (A) the Commission has issued a stop order with respect to the Registration
Statement, (B) the Commission otherwise has suspended or withdrawn the effectiveness of the Registration Statement, either temporarily
or permanently, (C) the Company has suspended or withdrawn the effectiveness of the Registration Statement, either temporarily
or permanently, or (D) otherwise (each a “Restrictive Legend Event”). To the extent that a Restrictive Legend
Event occurs after the Holder has exercised a Warrant in accordance with the terms of the Warrants but prior to the delivery of
the Warrant ADSs, the Company shall, at the election of the Holder, which shall be given within five (5) days of receipt of such
notice of the Restrictive Legend Event, either (A) rescind the previously submitted Election to Purchase and the Company shall
return all consideration paid by registered holder for such shares upon such rescission or (B) treat the attempted exercise as
a cashless exercise as described in the next paragraph and refund the cash portion of the exercise price to the Holder.


 



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(ii) If a Restrictive Legend Event has
occurred and no exemption from the registration requirements is available, the Warrant shall only be exercisable on a cashless
basis. Notwithstanding anything herein to the contrary, the Company shall not be required to make any cash payments or net cash
settlement to the Holder in lieu of delivery of the Warrant ADSs. Upon a “cashless exercise”, the Holder shall be entitled
to receive the number of Warrant ADSs equal to the quotient obtained by dividing (A-B) (X) by (A), where:


 


	 	(A)	= the VWAP on the Business Day immediately preceding the Exercise Date;


 


	 	(B)	= the Exercise Price of the Warrant, as adjusted as set forth herein; and


 


	 	(X)	= the number of Warrant ADSs that would be issuable upon exercise of the Warrant in accordance with the terms of the Warrant if such exercise were by means of a cash exercise rather than a cashless exercise.


 


Upon receipt of an Election to Purchase
for a cashless exercise, the Warrant Agent will promptly deliver a copy of the Election to Purchase to the Company to confirm the
number of Warrant ADSs issuable in connection with the cashless exercise. The Company shall calculate and transmit to the Warrant
Agent in a written notice, and the Warrant Agent shall have no duty, responsibility or obligation under this section to calculate,
the number of Warrant ADSs issuable in connection with any cashless exercise. The Warrant Agent shall be entitled to rely conclusively
on any such written notice provided by the Company, and the Warrant Agent shall not be liable for any action taken, suffered or
omitted to be taken by it in accordance with such written instructions or pursuant to this Warrant Agreement.




A Holder that exercises Warrants in a cashless exercise will still be required to pay the applicable Issuance Fee as a condition
of making that exercise.


 


3.3.8 Disputes. In the case of
a dispute as to the determination of the Exercise Price or the arithmetic calculation of the Warrant ADSs, the Company shall promptly
deliver to the Holder the number of Warrant ADSs that are not disputed.


 


4. Adjustments.


 


4.1 Adjustment upon Subdivisions or
Combinations. If the Company at any time after the Issuance Date subdivides (by any stock split, stock dividend, recapitalization,
reorganization, scheme, arrangement or otherwise) its outstanding Ordinary Shares into a greater number of or Ordinary Shares or
the ratio of Shares per ADS is reduced, the Exercise Price in effect immediately prior to such subdivision will be proportionately
reduced and the number of Warrant ADSs will be proportionately increased. If the Company at any time after the Issuance Date combines
(by any stock split, stock dividend, recapitalization, reorganization, scheme, arrangement or otherwise) its outstanding Ordinary
Shares into a smaller number of Ordinary Shares or the ratio of Shares per ADS is increased, the Exercise Price in effect immediately
prior to such combination will be proportionately increased and the number of Warrant ADSs will be proportionately decreased. Any
adjustment under this Section 4.1 shall become effective at the close of business on the date the subdivision or combination or
ratio change becomes effective. The Company shall promptly notify the Warrant Agent in writing of any adjustment to the Warrants
and give specific instructions to the Warrant Agent with respect to any adjustments to the warrant register.


 


4.2 Adjustment for Other Distributions.
In the event the Company shall fix a record date for the making of a dividend or distribution to all holders of Ordinary Shares
of any evidences of indebtedness or assets or subscription rights or warrants (excluding those referred to in Section 4.1 or other
dividends paid out of retained earnings), then in each such case the Holder will, upon the exercise of Warrants, be entitled to
receive, in addition to the number of Warrant ADSs issuable thereupon, and without payment of any additional consideration therefor,
the amount of such dividend or distribution, as applicable, which such Holder would hold on the date of such exercise had such
Holder been the holder of record of such Warrant ADSs as of the date on which holders of ADSs became entitled to receive such dividend
or distribution. Such adjustment shall be made whenever any such distribution is made and shall become effective immediately after
the record date mentioned above.


 



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4.3. Reclassification, Consolidation,
Purchase, Combination, Sale or Conveyance. If, at any time while the Warrants are outstanding, (i) the Company, directly or
indirectly, in one or more related transactions effects any merger or consolidation of the Company with or into another person,
(ii) the Company, directly or indirectly, effects any sale, lease, license, assignment, transfer, conveyance or other disposition
of all or substantially all of its assets in one or a series of related transactions, (iii) any, direct or indirect, purchase offer,
tender offer or exchange offer (whether by the Company or another person) is completed pursuant to which holders of Ordinary Shares
(including those represented by ADSs) are permitted to sell, tender or exchange their shares for other securities, cash or property
and has been accepted by the holders of 50% or more of the outstanding Ordinary Shares (including those represented by ADSs), (iv)
the Company, directly or indirectly, in one or more related transactions effects any reclassification, reorganization or recapitalization
of ADSs or Ordinary Shares or any compulsory share exchange pursuant to which the ADSs or Ordinary Shares are effectively converted
into or exchanged for other securities, cash or property, (v) the Company, directly or indirectly, in one or more related transactions
consummates a stock or share purchase agreement or other business combination (including, without limitation, a reorganization,
recapitalization, spin-off or scheme of arrangement) with another person whereby such other person acquires more than 50% of the
outstanding Ordinary Shares (including those represented by ADSs) (not including any Ordinary Shares (including those represented
by ADSs) held by the other person or other persons making or party to, or associated or affiliated with the other persons making
or party to, such stock or share purchase agreement or other business combination) (each a “Fundamental Transaction”),
then, upon any subsequent exercise of a Warrant, the registered holder shall have the right to receive, for each Warrant Share
that would have been issuable upon such exercise immediately prior to the occurrence of such Fundamental Transaction, the number
of shares, if any, of the successor or acquiring corporation or of the Company, if it is the surviving corporation, or depositary
shares representing those shares, and any additional consideration (the “Alternate Consideration”) receivable
as a result of such Fundamental Transaction by a holder of the number of ADSs for which this Warrant is exercisable immediately
prior to such Fundamental Transaction. For purposes of any such exercise, the determination of the Exercise Price shall be appropriately
adjusted to apply to such Alternate Consideration based on the amount of Alternate Consideration issuable in respect of one ADS
in such Fundamental Transaction, and the Company shall apportion the Exercise Price among the Alternate Consideration in a reasonable
manner reflecting the relative value of any different components of the Alternate Consideration. If holders of ADSs are given any
choice as to the securities, cash or property to be received in a Fundamental Transaction, then the Holder shall be given the same
choice as to the Alternate Consideration it receives upon any exercise of this Warrant following such Fundamental Transaction.
The Company shall cause any successor entity in a Fundamental Transaction in which the Company is not the survivor (the “Successor
Entity”) and for which shareholders received any equity securities of the Successor Entity, to assume in writing all of the
obligations of the Company under this Warrant Agreement in accordance with the provisions of this Section 4.3 pursuant to written
agreements and shall, upon the written request of the registered holder of a Warrant, deliver to the registered holder in exchange
for this Warrant created by this Warrant Agreement a security of the Successor Entity evidenced by a written instrument substantially
similar in form and substance to the Warrant which is exercisable for a corresponding number of shares of capital stock of such
Successor Entity (or its parent entity), if any, plus any Alternate Consideration, receivable as a result of such Fundamental Transaction
by a holder of the number of Warrant Shares for which the Warrant is exercisable immediately prior to such Fundamental Transaction,
and with an exercise price which applies the exercise price hereunder to such shares of capital stock, if any, plus any Alternate
Consideration (but taking into account the relative value of the ADSs or Ordinary Shares pursuant to such Fundamental Transaction
and the value of such shares of capital stock, such number of shares of capital stock and such exercise price being for the purpose
of protecting the economic value of such Warrant immediately prior to the consummation of such Fundamental Transaction). Upon the
occurrence of any such Fundamental Transaction the Successor Entity shall succeed to, and be substituted for (so that from and
after the date of such Fundamental Transaction, the provisions of this Warrant Agreement and the Warrant referring to the “Company”
shall refer instead to the Successor Entity), and may exercise every right and power of the Company and shall assume all of the
obligations of the Company under this Warrant Agreement and the Warrant with the same effect as if such Successor Entity had been
named as the Company herein.


 


The Company shall instruct the Warrant
Agent in writing to mail by first class mail, postage prepaid, to each Holder, written notice of the execution of any such amendment,
supplement or agreement. Any supplemented or amended agreement entered into by the successor corporation or transferee shall provide
for adjustments, which shall be as nearly equivalent as may be practicable to the adjustments provided for in this Section 4.3.
The Warrant Agent shall have no duty, responsibility or obligation to determine the correctness of any provisions contained in
such agreement or such notice, including but not limited to any provisions relating either to the kind or amount of securities
or other property receivable upon exercise of warrants or with respect to the method employed and provided therein for any adjustments,
and shall be entitled to rely conclusively for all purposes upon the provisions contained in any such agreement. The provisions
of this Section 4.3 shall similarly apply to successive reclassifications, changes, consolidations, mergers, sales and conveyances
of the kind described above.


 



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4.4. Adjustment Upon Issuance of ADSs.
If and whenever on or after the Issuance Date and prior to [          ], 2016 [Insert
one year following closing] (the “Applicable Period”), the Company issues, sells or delivers, or in accordance
with this Section 4 is deemed to have issued, sold or delivered , any ADSs or Ordinary Shares (including the issuance, sale or
delivery of ADSs or Ordinary Shares owned or held by or for the account of the Company, but excluding any Excluded Securities issued
or sold or deemed to have been issued, sold or delivered) for a consideration per share less than a price equal to the Exercise
Price, in the case of an ADS, or less than a price equal to the Ordinary Share Equivalent Price, in the case of an Ordinary Share,
in each case in effect immediately prior to such issuance, sale or delivery or deemed issuance, sale or delivery (such Exercise
Price or Ordinary Share Equivalent Price, as the case may be, then in effect is referred to as the “Applicable Price”)
(the foregoing a “Dilutive Issuance”), then immediately after such Dilutive Issuance, the Exercise Price then
in effect shall be reduced to the New Issuance Price. For all purposes of the foregoing (including, without limitation, determining
the adjusted Exercise Price and consideration per share under this Section 4.4), the following shall be applicable:


 


(i) Issuance
of Options. If the Company grants or sells any Options (other than Options that qualify as Excluded Securities) during the
Applicable Period and the lowest price per share for which one ADS or Ordinary Share is issuable upon the exercise of any such
Option or upon conversion, exercise or exchange of any Convertible Securities issuable upon exercise of any such Option is less
than the Applicable Price, then such ADS or Ordinary Share shall be deemed to be outstanding and to have been issued and sold or
delivered by the Company at the time of the granting or sale of such Option for the New Issuance Price. For purposes of this Section
4.4(i), the “lowest price per share for which one ADS or Ordinary Share is issuable upon the exercise of any such Options
or upon conversion, exercise or exchange of any Convertible Securities issuable upon exercise of any such Option” shall be
equal to (1) the lower of (x) the sum of the lowest amounts of consideration (if any) received or receivable by the Company with
respect to any one ADS or Ordinary Share upon the granting or sale of such Option, upon exercise of such Option and upon conversion,
exercise or exchange of any Convertible Security issuable upon exercise of such Option and (y) the lowest exercise price set forth
in such Option for which one ADS or Ordinary Shares is issuable upon the exercise of any such Options or upon conversion, exercise
or exchange of any Convertible Securities issuable upon exercise of any such Option minus (2) the sum of all amounts paid or payable
to the holder of such Option (or any other person or entity) upon the granting or sale of such Option, upon exercise of such Option
and upon conversion, exercise or exchange of any Convertible Security issuable upon exercise of such Option plus the value of any
other consideration received or receivable by, or benefit conferred on, the holder of such Option (or any other person or entity).
Except as contemplated below, no further adjustment of the Exercise Price shall be made upon the actual issuance of such ADSs or
Ordinary Shares or of such Convertible Securities upon the exercise of such Options or upon the actual issuance of such ADSs or
Ordinary Shares upon conversion, exercise or exchange of such Convertible Securities.


 


(ii) Issuance
of Convertible Securities. If the Company issues or sells any Convertible Securities (other than Convertible Securities that
qualify as Excluded Securities) during the Applicable Period and the lowest price per share for which one ADS or Ordinary Share
is issuable upon the conversion, exercise or exchange thereof is less than the Applicable Price, then such ADS or Ordinary Share
shall be deemed to be outstanding and to have been issued and sold or delivered by the Company at the time of the issuance or sale
of such Convertible Securities for the New Issuance Price. For the purposes of this Section 4.4(ii), the “lowest price per
share for which one ADS or Ordinary Share is issuable upon the conversion, exercise or exchange thereof” shall be equal to
(1) the lower of (x) the sum of the lowest amounts of consideration (if any) received or receivable by the Company with respect
to one ADS or Ordinary Share upon the issuance or sale of the Convertible Security and upon conversion, exercise or exchange of
such Convertible Security and (y) the lowest conversion price set forth in such Convertible Security for which one Common Share
is issuable upon conversion, exercise or exchange thereof minus (2) the sum of all amounts paid or payable to the holder of such
Convertible Security (or any other person or entity) upon the issuance or sale of such Convertible Security plus the value of any
other consideration received or receivable by, or benefit conferred on, the holder of such Convertible Security (or any other person
or entity). Except as contemplated below, no further adjustment of the Exercise Price shall be made upon the actual issuance of
such ADSs or Ordinary Shares upon conversion, exercise or exchange of such Convertible Securities, and if any such issue or sale
of such Convertible Securities is made upon exercise of any Options for which adjustment of Warrants has been or is to be made
pursuant to other provisions of this Section 4.4, except as contemplated below, no further adjustment of the Exercise Price shall
be made by reason of such issue, sale or delivery.


 



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(iii) Change in Option Price.
If during the Applicable Period the purchase or exercise price provided for in any Options, the additional consideration, if any,
payable upon the issue, conversion, exercise or exchange of any Convertible Securities or the rate at which any Convertible Securities
are convertible into or exercisable or exchangeable for ADSs or Ordinary Shares increases or decreases at any time, the Exercise
Price in effect at the time of such increase or decrease shall be adjusted to the Exercise Price which would have been in effect
at such time had such Options or Convertible Securities provided for such increased or decreased purchase price, additional consideration
or increased or decreased conversion rate, as the case may be, at the time initially granted, issued or sold. For purposes of
this Section 4.4(iii), if the terms of any Option or Convertible Security that was outstanding as of the original issuance of
the Warrants are increased or decreased in the manner described in the immediately preceding sentence, then such Option or Convertible
Security and the ADSs or Ordinary Shares deemed issuable upon exercise, conversion or exchange thereof shall be deemed to have
been issued as of the date of such increase or decrease. No adjustment pursuant to this Section 4.4 shall be made if such adjustment
would result in an increase of the Exercise Price then in effect.


 


(iv) Calculation of Consideration
Received. If during the Applicable Period any Option and/or Convertible Security and/or Adjustment Right is issued in connection
with the issuance or sale or deemed issuance or sale of any other securities of the Company or ADSs (as determined by the Holder,
the “Primary Security”, and such Option and/or Convertible Security and/or Adjustment Right, the “Secondary
Securities”), together comprising one integrated transaction, (other than Options or Convertible Security that qualify
as Excluded Securities) the consideration per ADS or Ordinary Share with respect to such Primary Security shall be deemed to be
equal to the difference of (x) the lowest price per share for which one ADS or Ordinary Share was issued in such integrated transaction
(or was deemed to be issued pursuant to Section 4.4(i) or 4.4(ii) above, as applicable) solely with respect to such Primary Security,
minus (y) with respect to such Secondary Securities, the sum of (I) the Black Scholes Consideration Value of each such Option,
if any, (II) the fair market value (as determined by the Holder) or the Black Scholes Consideration Value, as applicable, of such
Adjustment Right, if any, and (III) the fair market value (as determined by the Holder) of such Convertible Security, if any, in
each case, as determined on a per share basis in accordance with this Section 4.4(iv). If any ADSs, Ordinary Shares, Options or
Convertible Securities are issued or sold or deemed to have been issued or sold for cash, the consideration received therefor (for
the purpose of determining the consideration paid for such ADSs, Ordinary Shares, Option or Convertible Security, but not for the
purpose of the calculation of the Black Scholes Consideration Value) will be deemed to be the net amount of consideration received
by the Company therefor. If any ADSs, Ordinary Shares, Options or Convertible Securities are issued or sold for a consideration
other than cash (for the purpose of determining the consideration paid for such ADSs, Ordinary Shares, Option or Convertible Security,
but not for the purpose of the calculation of the Black Scholes Consideration Value), the amount of such consideration received
by the Company will be the fair value of such consideration, except where such consideration consists of publicly traded securities,
in which case the amount of consideration received by the Company for such securities will be the arithmetic average of the VWAPs
of such security for each of the five (5) Trading Days immediately preceding the date of receipt. If any ADSs, Ordinary Shares,
Options or Convertible Securities are issued to the owners of the non-surviving entity in connection with any merger in which the
Company is the surviving entity (for the purpose of determining the consideration paid for such ADSs, Ordinary Shares, Option or
Convertible Security, but not for the purpose of the calculation of the Black Scholes Consideration Value), the amount of consideration
therefor will be deemed to be the fair value of such portion of the net assets and business of the non-surviving entity as is attributable
to such ADSs, Ordinary Shares, Options or Convertible Securities, as the case may be. The fair value of any consideration other
than cash or publicly traded securities (for the purpose of determining the consideration paid for such ADSs, Ordinary Shares,
Option or Convertible Security, but not for the purpose of the calculation of the Black Scholes Consideration Value) will be determined
jointly by the Company and the Holder. If such parties are unable to reach agreement within ten (10) days after the occurrence
of an event requiring valuation (the “Valuation Event”), the fair value of such consideration will be determined
within five (5) Trading Days after the tenth (10th) day following such Valuation Event by an independent, reputable
appraiser jointly selected by the Company and the Holder. The determination of such appraiser shall be final and binding upon all
parties absent manifest error and the fees and expenses of such appraiser shall be borne by the Company.


 



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4.5 Other Events. If any event
occurs of the type contemplated by the provisions of Section 4.1, 4.2 or 4.4 but not expressly provided for by such provisions
(including, without limitation, the granting of stock appreciation rights, phantom stock rights or other rights with equity features
to all holders of ADSs for no consideration), then the Company's Board of Directors will, at its discretion and in good faith,
make an adjustment in the Exercise Price and the number of Warrant ADSs or designate such additional consideration to be deemed
issuable upon exercise of a Warrant, so as to protect the rights of the registered holder.


 


4.6. Notices of Changes in Warrant.
Upon every adjustment of the Exercise Price or the number of Warrant ADSs issuable upon exercise of a Warrant, the Company shall
give written notice thereof to the Warrant Agent, which notice shall state the Exercise Price resulting from such adjustment and
the increase or decrease, if any, in the number of Warrant ADSs purchasable at such price upon the exercise of a Warrant, setting
forth in reasonable detail the method of calculation and the facts upon which such calculation is based. Upon the occurrence of
any event specified in Sections 4.1 or 4.2, then, in any such event, the Company shall give written notice to each Holder, at the
last address set forth for such holder in the warrant register, of the record date or the effective date of the event. Failure
to give such notice, or any defect therein, shall not affect the legality or validity of such event. The Warrant Agent shall be
entitled to rely conclusively on, and shall be fully protected in relying on, any certificate, notice or instructions provided
by the Company with respect to any adjustment of the Exercise Price or the number of shares issued able upon exercise of a Warrant,
or any related matter, and the Warrant Agent shall not be liable for any action taken, suffered or omitted to be taken by it in
accordance with any such certificate, notice or instructions or pursuant to this Warrant Agreement. The Warrant Agent shall not
be deemed to have knowledge of any such adjustment unless and until it shall have received written notice thereof from the Company.


 


5. Restrictive Legends; Fractional
Warrants.


 


In the event that a Warrant Certificate
surrendered for transfer bears a restrictive legend, the Warrant Agent shall not cancel such Warrant Certificate and deliver new
Warrant Certificates in exchange therefor until the Warrant Agent has received an opinion of counsel for the Company stating that
such transfer may be made and indicating whether the Warrants must also bear a restrictive legend upon that transfer. The Warrant
Agent shall not be required to effect any registration of transfer or exchange which will result in the transfer of or delivery
of a Warrant Certificate for a fraction of a Warrant.


  


6. Limitations on Exercise. The
Company shall not, and shall not instruct the Warrant Agent to, effect any exercise of any Warrant, and a Holder shall not have
the right to exercise any Warrants, to the extent that after giving effect to the issuance of Warrant ADSs after exercise as set
forth on the applicable Election to Purchase, that Holder or a person holding through that Holder (together with such Holder’s
or person’s Affiliates (as defined in Rule 405 under the Securities Act of 1933), and any other persons acting as a group
together with that Holder or person or any of that Holder’s or person’s Affiliates), would beneficially own in excess
of 4.99% of the Company’s Ordinary Shares. For purposes of the foregoing sentence, the number of Ordinary Shares beneficially
owned by a person shall include the number of Ordinary Shares underlying the Warrant ADSs that would be owned by that person issuable
upon exercise of the Warrants with respect to which such determination is being made, but shall exclude the number of Ordinary
Shares underlying the Warrant ADSs which would be issuable upon exercise of the remaining, non-exercised Warrants beneficially
owned by that person or any of its Affiliates. Except as set forth in the preceding sentence, for purposes of this Section 6, beneficial
ownership shall be calculated in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder,
it being acknowledged by the Holder that neither the Warrant Agent nor the Company is representing to the Holder that such calculation
is in compliance with Section 13(d) of the Exchange Act and the Holder or beneficial owner is solely responsible for any schedules
required to be filed in accordance therewith. To the extent that the limitation contained in this Section 6 applies, the determination
of whether a Warrant is exercisable (in relation to other securities owned by a Holder or persons holding through a Holder together
with any Affiliates) and of the number of Warrants that are exercisable shall be in the sole discretion of the Holder, and the
submission of an Election to Purchase shall be deemed to be the Holder’s determination of whether such Warrant is exercisable
(in relation to other securities owned by the Holder, persons holding through the Holder together with any Affiliates) and of the
number of Warrants that are exercisable, and neither the Warrant Agent nor the Company shall have any obligation to verify or confirm
the accuracy of such determination and neither of them shall have any liability for any error made by the Holder or any other person.
In addition, a determination as to any group status as contemplated above shall be determined in accordance with Section 13(d)
of the Exchange Act and the rules and regulations promulgated thereunder. For purposes of this Section 6, in determining the number
of outstanding Ordinary Shares, a Holder or other person may rely on the number of outstanding Ordinary Shares as reflected in
(A) the Company’s most recent periodic or annual report filed with the Securities and Exchange Commission, as the case may
be, (B) a more recent public announcement by the Company or (C) a more recent written notice by the Company or the Company’s
transfer agent setting forth the number of Ordinary Shares outstanding. The provisions of this Section 6 shall be construed and
implemented in a manner otherwise than in strict conformity with the terms of this Section 6 to correct this subsection (or any
portion hereof) which may be defective or inconsistent with the intended beneficial ownership limitation herein contained or to
make changes or supplements necessary or desirable to properly give effect to such limitation. The limitations contained in this
paragraph shall apply to a Holder of Warrants.


 



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7. Other Provisions Relating to Rights
of Holders of Warrants.


 


7.1. No Rights as Stockholder.
Except as otherwise specifically provided herein, a Holder, solely in its capacity as a holder of Warrants, shall not be entitled
to vote or receive dividends or be deemed the holder of share capital of the Company for any purpose, nor shall anything contained
in this Warrant Agreement be construed to confer upon a Holder, solely in its capacity as the registered holder of Warrants, any
of the rights of a stockholder of the Company or any right to vote, give or withhold consent to any corporate action (whether any
reorganization, issue of stock, reclassification of stock, consolidation, merger, conveyance or otherwise), receive notice of meetings,
receive dividends or subscription rights, or otherwise, prior to the issuance to the Holder of the Warrant ADSs which it is then
entitled to receive upon the due exercise of Warrants.


 


7.2. Reservation of Ordinary Shares.
The Company shall at all times reserve and keep available a number of its authorized but unissued Ordinary Shares that will be
sufficient to permit the exercise in full of all outstanding Warrants issued pursuant to this Warrant Agreement.


 


8. Concerning the Warrant Agent and
Other Matters.


 


8.1. Any instructions given to the Warrant
Agent orally, as permitted by any provision of this Warrant Agreement, shall be confirmed in writing by the Company as soon as
practicable. The Agent shall not be liable or responsible and shall be fully authorized and protected for acting, or failing to
act, in accordance with any oral instructions which do not conform with the written confirmation received in accordance with this
Section 8.1.


 


8.2. (a) Whether or not any Warrants are
exercised, for the Warrant Agent’s services as Agent hereunder, the Company shall pay to the Warrant Agent it’s out
of pocket expenses in connection with this Warrant Agreement, including, without limitation, the charges of Computershare for providing
services to the Warrant Agent with respect to the Warrants and the expenses for which the Warrant Agent is obliged to reimburse
Computershare, and the fees and expenses of the Warrant Agent’s counsel. While the Warrant Agent endeavors to maintain out-of-pocket
charges (both internal and external) at competitive rates, these charges may not reflect actual out-of-pocket costs, and may include
handling charges to cover internal processing and use of the Warrant Agent’s billing systems.


 


(b) All amounts owed to the Warrant Agent
under this Warrant Agreement are due within 30 days of the invoice date. Delinquent payments are subject to a late payment charge
of one and one-half percent (1.5%) per month commencing 45 days from the invoice date. The Company agrees to reimburse the Warrant
Agent for any attorney’s fees and any other costs associated with collecting delinquent payments.


 


(c) No provision of this Warrant Agreement
shall require Warrant Agent to expend or risk its own funds or otherwise incur any financial liability in the performance of any
of its duties under this Warrant Agreement or in the exercise of its rights.


 



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8.3 As Warrant Agent for the Company hereunder
the Warrant Agent:


 


(a) shall have no duties
or obligations other than those specifically set forth herein or as may subsequently be agreed to in writing by the Warrant Agent
and the Company;


 


(b) shall have no obligation
to effect any delivery of Warrant ADSs other than to instruct the Depositary with respect to that delivery;


 


(c) shall be regarded
as making no representations and having no responsibilities as to the validity, sufficiency, value, or genuineness of the Warrants
or any Warrant Shares or Warrant ADSs;


 


(d) shall not be obligated
to take any legal action hereunder; if, however, the Warrant Agent determines to take any legal action hereunder, and where the
taking of such action might, in its judgment, subject or expose it to any expense or liability it shall not be required to act
unless it has been furnished with an indemnity satisfactory to it;


 


(e) may rely on and
shall be fully authorized and protected in acting or failing to act upon any certificate, instrument, opinion, notice, letter,
telegram, telex, facsimile transmission or other document or security delivered to the Warrant Agent and believed by it to be genuine
and to have been signed by the proper party or parties;


 


(f) shall not be liable
or responsible for any recital or statement contained in the Registration Statement or any other documents relating thereto;


 


(g) shall not be liable
or responsible for any failure on the part of the Company to comply with any of its covenants and obligations relating to the Warrants,
including without limitation obligations under applicable securities laws;


 


(h) may rely on and
shall be fully authorized and protected in acting or failing to act upon the written, telephonic or oral instructions with respect
to any matter relating to its duties as Warrant Agent covered by this Warrant Agreement (or supplementing or qualifying any such
actions) of officers of the Company, and is hereby authorized and directed to accept instructions with respect to the performance
of its duties hereunder from the Company or counsel to the Company, and may apply to the Company, for advice or instructions in
connection with the Warrant Agent’s duties hereunder, and the Warrant Agent shall not be liable for any delay in acting while
waiting for those instructions; any applications by the Warrant Agent for written instructions from the Company may, at the option
of the Agent, set forth in writing any action proposed to be taken or omitted by the Warrant Agent under this Warrant Agreement
and the date on or after which such action shall be taken or such omission shall be effective; the Warrant Agent shall not be liable
for any action taken by, or omission of, the Warrant Agent in accordance with a proposal included in such application on or after
the date specified in such application (which date shall not be less than two business days after the date such application is
sent to the Company, unless the Company shall have consented in writing to any earlier date) unless prior to taking any such action,
the Warrant Agent shall have received written instructions in response to such application specifying the action to be taken or
omitted;


 


(i) may consult with
counsel satisfactory to the Warrant Agent, including its in-house counsel, and the advice of such counsel shall be full and complete
authorization and protection in respect of any action taken, suffered, or omitted by it hereunder in good faith and in accordance
with the advice of such counsel;


 


(j) may perform any
of its duties hereunder either directly or by or through nominees, correspondents, designees, subagents or subcustodians, and it
shall not be liable or responsible for any misconduct or negligence on the part of any nominee, correspondent, designee, subagent
or subcustodian appointed with reasonable care by it in connection with this Warrant Agreement;


 


(k) is not authorized,
and shall have no obligation, to pay any brokers, dealers, or soliciting fees to any person and


 


(l) shall not be required
hereunder to comply with the laws or regulations of any country other than the United States of America or any political subdivision
thereof; and Warrant Agent may consult with foreign counsel, at the Company’s expense, to resolve any foreign law issues
that may arise as a result of the Company or any other party being subject to the laws or regulations of any foreign jurisdiction.


 



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8.4. (a) In the absence of gross negligence
or willful misconduct on its part, the Warrant Agent shall not be liable for any action taken, suffered, or omitted by it or for
any error of judgment made by it in the performance of its duties under this Warrant Agreement. Anything in this Warrant Agreement
to the contrary notwithstanding, in no event shall Warrant Agent be liable for special, indirect, incidental, consequential or
punitive losses or damages of any kind whatsoever (including but not limited to lost profits), even if the Warrant Agent has been
advised of the possibility of such losses or damages and regardless of the form of action. Any liability of the Warrant Agent will
be limited in the aggregate to the amount of fees paid by the Company hereunder. The Warrant Agent shall not be liable for any
failures, delays or losses, arising directly or indirectly out of conditions beyond its reasonable control including, but not limited
to, acts of government, exchange or market ruling, suspension of trading, work stoppages or labor disputes, fires, civil disobedience,
riots, rebellions, storms, electrical or mechanical failure, computer hardware or software failure, communications facilities failures
including telephone failure, war, terrorism, insurrection, earthquakes, floods, acts of God or similar occurrences.


 


(b) In the event any question or dispute
arises with respect to the proper interpretation of the Warrants or the Warrant Agent’s duties under this Warrant Agreement
or the rights of the Company or of any Holder, the Warrant Agent shall not be required to act and shall not be held liable or responsible
for its refusal to act until the question or dispute has been judicially settled (and, if appropriate, it may file a suit in interpleader
or for a declaratory judgment for such purpose) by final judgment rendered by a court of competent jurisdiction, binding on all
persons interested in the matter which is no longer subject to review or appeal, or settled by a written document in form and substance
satisfactory to you and executed by the Company and each such holder. In addition, the Warrant Agent may require for such purpose,
but shall not be obligated to require, the execution of such written settlement by all the Holders and all other persons that may
have an interest in the settlement.


 


8.5. The Company covenants to indemnify
the Warrant Agent and hold it harmless from and against any loss, liability, claim or expense (“Loss”) arising out
of or in connection with the Warrant Agent’s duties under this Warrant Agreement, including the costs and expenses of defending
itself against any Loss, unless such Loss shall have been determined by a court of competent jurisdiction to be a result of the
Warrant Agent’s gross negligence or willful misconduct.


 


8.6. Unless terminated earlier by the
parties hereto, this Agreement shall terminate 90 days after the earlier of the Expiration Date and the date on which no Warrants
remain outstanding (the “Termination Date”). On the business day following the Termination Date, the Agent shall
deliver to the Company any entitlements, if any, held by the Warrant Agent under this Warrant Agreement. The Agent’s right
to be reimbursed for fees, charges and out-of-pocket expenses as provided in this Section 8 shall survive the termination of this
Warrant Agreement.


 


8.7. If any provision of this Warrant
Agreement shall be held illegal, invalid, or unenforceable by any court, this Warrant Agreement shall be construed and enforced
as if such provision had not been contained herein and shall be deemed an Agreement among the parties to it to the full extent
permitted by applicable law.


 


8.8. The Company represents and warrants
that (a) it is duly incorporated, validly existing and in good standing under the laws of its jurisdiction of incorporation, (b)
the offer and sale of the Warrants and the execution, delivery and performance of all transactions contemplated thereby (including
this Warrant Agreement) have been duly authorized by all necessary corporate action and will not result in a breach of or constitute
a default under the articles of association, bylaws or any similar document of the Company or any indenture, agreement or instrument
to which it is a party or is bound, (c) this Warrant Agreement has been duly executed and delivered by the Company and constitutes
the legal, valid, binding and enforceable obligation of the Company, (d) the Warrants will comply in all material respects with
all applicable requirements of law and (e) to the best of its knowledge, there is no litigation pending or threatened as of the
date hereof in connection with the offering of the Warrants.


 



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8.9. In the event that any claim of inconsistency
between this Warrant Agreement and the descriptions in the Registration Statement, as they may from time to time be amended, the
terms of this Warrant Agreement shall control.


 


8.10. Set forth in Annex C hereto is a
list of the names and specimen signatures of the persons authorized to act for the Company under this Warrant Agreement (the “Authorized
Representatives”). The Company shall, from time to time, certify to you the names and signatures of any other persons
authorized to act for the Company under this Warrant Agreement.


 


8.11. Except as expressly set forth elsewhere
in this Warrant Agreement, all notices, instructions and communications under this Agreement shall be in writing, shall be effective
upon receipt and shall be addressed, if to the Company, to its address set forth beneath its signature to this Agreement, or, if
to the Agent, to The Bank of New York Mellon, 101 Barclay Street, 22 West, New York, New York 10286, Attention: Arlene Villareal,
Relationship Manager, BionVax, Telephone: 212-815-8162, Facsimile: 212-571-3050, with a copy to Shareowner Services, 480 Washington
Boulevard, Jersey City, New Jersey 07310, Attention: _________, Telephone: _______, Facsimile: ________, or to such other address
of which a party hereto has notified the other party.


 


8.12. (a) This Warrant Agreement shall
be governed by and construed in accordance with the laws of the State of New York. All actions and proceedings brought by the Warrant
Agent relating to or arising from, directly or indirectly, this Warrant Agreement may be litigated in courts located within the
State of New York. The Company hereby submits to the personal jurisdiction of such courts and consents that any service of process
may be made by certified or registered mail, return receipt requested, directed to the Company at its address last specified for
notices hereunder. Each of the parties hereto hereby waives the right to a trial by jury in any action or proceeding arising out
of or relating to this Warrant Agreement.


 


(b) This Warrant Agreement shall inure
to the benefit of and be binding upon the successors and assigns of the parties hereto. This Warrant Agreement may not be assigned,
or otherwise transferred, in whole or in part, by either party without the prior written consent of the other party, which the
other party will not unreasonably withhold, condition or delay; except that (i) consent is not required for an assignment
or delegation of duties by Warrant Agent to any affiliate of Warrant Agent and (ii) any reorganization, merger, consolidation,
sale of assets or other form of business combination by Warrant Agent shall not be deemed to constitute an assignment of this Warrant
Agreement.


 


(c) No provision of this Warrant Agreement
may be amended, modified or waived, except in a written document signed by both parties.


 


8.13 Payment of Taxes. The Company
will from time to time promptly pay all taxes and charges that may be imposed upon the Company or the Warrant Agent in respect
of the issuance or delivery of Warrant Shares or Warrant ADSs upon the exercise of Warrants, but the Company may require the Holders
to pay any transfer taxes in respect of the Warrants or such shares. The Warrant Agent may refrain from registering any transfer
of Warrants or any delivery of any Warrant ADSs unless or until the persons requesting the registration or issuance shall have
paid to the Warrant Agent for the account of the Company the amount of such tax or charge, if any, or shall have established to
the reasonable satisfaction of the Company and the Warrant Agent that such tax or charge, if any, has been paid.


 



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8.14 Resignation of Warrant Agent.


 


8.14.1. Appointment of Successor Warrant
Agent. The Warrant Agent, or any successor to it hereafter appointed, may resign its duties and be discharged from all further
duties and liabilities hereunder after giving thirty (30) days’ notice in writing to the Company, or such shorter period
of time agreed to by the Company. If the office of the Warrant Agent becomes vacant by resignation or incapacity to act or otherwise,
the Company shall appoint in writing a successor Warrant Agent in place of the Warrant Agent. If the Company shall fail to make
such appointment within a period of 30 days after it has been notified in writing of such resignation or incapacity by the Warrant
Agent or by a Holder of Warrants (who shall, with such notice, submit his Warrant Certificate for inspection by the Company), then
the Warrant Agent or any Holder may apply to the any court of competent jurisdiction for the appointment of a successor Warrant
Agent at the Company’s cost. Pending appointment of a successor to such Warrant Agent, either by the Company or by such a
court, the duties of the Warrant Agent shall be carried out by the Company. Any successor Warrant Agent (but not including the
initial Warrant Agent), whether appointed by the Company or by such court, shall be a person organized and existing under the laws
of any state or of the United States of America, in good standing, and authorized under such laws to exercise shareowner services
powers and subject to supervision or examination by federal or state authority. After appointment, any successor Warrant Agent
shall be vested with all the authority, powers, rights, immunities, duties, and obligations of its predecessor Warrant Agent with
like effect as if originally named as Warrant Agent hereunder, without any further act or deed, and except for executing and delivering
documents as provided in the sentence that follows, the predecessor Warrant Agent shall have no further duties, obligations, responsibilities
or liabilities hereunder, but shall be entitled to all rights that survive the termination of this Warrant Agreement and the resignation
or removal of the Warrant Agent, including but not limited to its right to indemnity hereunder. If for any reason it becomes necessary
or appropriate, the predecessor Warrant Agent shall execute and deliver, at the expense of the Company, an instrument transferring
to such successor Warrant Agent all the authority, powers, and rights of such predecessor Warrant Agent hereunder; and upon request
of any successor Warrant Agent the Company shall make, execute, acknowledge, and deliver any and all instruments in writing for
more fully and effectually vesting in and confirming to such successor Warrant Agent all such authority, powers, rights, immunities,
duties, and obligations.


 


8.14.2. Notice of Successor Warrant
Agent. In the event a successor Warrant Agent shall be appointed, the Company shall give notice thereof to the predecessor
Warrant Agent and the transfer agent for the ADSs not later than the effective date of any such appointment.


 


8.14.3. Merger or Consolidation of
Warrant Agent. Any person into which the Warrant Agent may be merged or converted or with which it may be consolidated or any
person resulting from any merger, conversion or consolidation to which the Warrant Agent shall be a party or any person succeeding
to the shareowner services business of the Warrant Agent or any successor Warrant Agent shall be the successor Warrant Agent under
this Warrant Agreement, without any further act or deed. For purposes of this Warrant Agreement, “person” shall mean
any individual, firm, corporation, partnership, limited liability company, joint venture, association, trust or other entity, and
shall include any successor (by merger or otherwise) thereof or thereto.


 


9. Miscellaneous Provisions.


 


9.1. Persons Having Rights under this
Warrant Agreement. Nothing in this Warrant Agreement expressed and nothing that may be implied from any of the provisions hereof
is intended, or shall be construed, to confer upon, or give to, any person or corporation other than the parties hereto and the
Holders any right, remedy, or claim under or by reason of this Warrant Agreement or of any covenant, condition, stipulation, promise,
or agreement hereof.


 


9.2. Examination of the Warrant Agreement.
A copy of this Warrant Agreement shall be available at all reasonable times at the office of the Warrant Agent designated for such
purpose for inspection by any Holder. Prior to such inspection, the Warrant Agent may require any such holder to submit his Warrant
Certificate for inspection by it.


 


9.3. Counterparts. This Warrant
Agreement may be executed in any number of original, facsimile or electronic counterparts and each of such counterparts shall for
all purposes be deemed to be an original, and all such counterparts shall together constitute but one and the same instrument.


 


9.4. Effect of Headings. The Section
headings herein are for convenience only and are not part of this Warrant Agreement and shall not affect the interpretation thereof.


 


10. Certain Definitions.


 


As used herein, the following terms shall
have the following meanings:


 





(i) “Adjustment Right” means
any right granted with respect to any securities issued in connection with, or with respect to, any issuance, sale or delivery
(or deemed issuance, sale or delivery in accordance with Section 4) of ADSs or Ordinary Shares (other than rights of the type
described in Section 4.2 and 4.3 hereof) that could result in a decrease in the net consideration received by the Company in connection
with, or with respect to, such securities (including, without limitation, any cash settlement rights, cash adjustment or other
similar rights) but excluding anti-dilution and other similar rights (including pursuant to Section 4.4 of this Agreement).


 



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(ii) “Approved Stock Plan”
means any employee benefit plan which has been approved by the board of directors of the Company prior to or subsequent to the
date hereof pursuant to which Ordinary Shares and standard options to purchase Ordinary Shares may be issued to any employee,
consultant, officer or director or other service provider for services provided to the Company in their capacity as such.


 


(iii) “Convertible Securities”
means any notes, rights, warrants or other securitits (other than Options) that are at any time and under any circumstances, directly
or indirectly, convertible into, exercisable or exchangeable for, or which otherwise entitles the holder thereof to acquire, any
ADSs or Ordinary Shares. 





(iv) “Excluded Securities”
means (1) Ordinary Shares or options or other rights to purchase Ordinary Shares or other awards issued to directors, officers
or employees of the Company in their capacity as such pursuant to an Approved Stock Plan, provided that (A) all such issuances
(taking into account the Ordinary Shares issuable upon exercise of such options) after the date hereof pursuant to this clause
(i) do not, in the aggregate, exceed more than 10% of the Ordinary Shares issued and outstanding immediately prior to the date
hereof and (B) the exercise price of any such options is not lowered, none of such options are amended to increase the number
of shares issuable thereunder in each case other than pursuant to the terms hereof (including any anti-dilution provisions contained
therein) and none of the terms or conditions of any such options are otherwise materially changed in any manner that adversely
affects any of the holders of Warrants; (2) Ordinary Shares issued upon the conversion or exercise of Convertible Securities (other
than options or other rights to purchase Ordinary Shares issued pursuant to an Approved Stock Plan that are covered by clause
(i) above) issued prior to the date hereof, provided that the conversion price of any such Convertible Securities (other than
options or other rights to purchase Ordinary Shares issued pursuant to an Approved Stock Plan that are covered by clause (1) above)
is not lowered through the amendment or waiver of such Convertible Security, none of such Convertible Securities (other than options
or other rights to purchase Ordinary Shares issued pursuant to an Approved Stock Plan that are covered by clause (1) above) are
amended to increase the number of shares issuable thereunder and none of the terms or conditions of any such Convertible Securities
(other than options or other rights to purchase Ordinary Shares issued pursuant to an Approved Stock Plan that are covered by
clause (1) above) are otherwise materially changed in any manner that adversely affects any of the holders of Warrants; (3) ADSs
and Ordinary Shares issuable upon exercise of the Warrants; and (4) securities issuable in connection with strategic license agreements
and other partnering arrangements where the purchaser or acquirer of the securities in such issuance solely consists of (A) either
(x) the actual participants in such strategic license, strategic alliance, strategic partnership or other partnering arrangements,
(y) the actual owners of such assets or securities acquired in such acquisition or merger or (z) the stockholders, partners or
members of the foregoing persons or entities and (B) number or amount of securities issued to such person or entity by the Company
shall not be disproportionate (as determined in good faith by the Board of Directors of the Company) to either (x) the fair market
value of such person’s or entity’s actual contribution to such strategic alliance or strategic partnership or (y)
the proportional ownership of such assets or securities to be acquired by the Company, as applicable; provided, that, notwithstanding
the foregoing, such purchaser or acquirer of the securities in such issuance shall not include any person regularly engaged in
the business of buying or selling securities.


 


(v) “New Issuance Price” means
either (i) in the case of an issuance or sale or deemed issuance or sale of ADSs, the price per ADS at which an ADS is sold in
such Dilutive Issuance, or (ii) in the case of an issuance or sale or deemed issuance or sale of Ordinary Shares, the product of
(x) the price per Ordinary Share at which an Ordinary Share is issued or sold or deemed issued or sold in such Dilutive Issuance,
multiplied by (ii) the rate of conversion of ADSs into Ordinary Shares in effect immediately prior to such issuance or sale or
deemed issuance or sale, and which shall initially be 40.


 


(vii) “Options” means any
rights, warrants or options to subscribe for or purchase ADSs, Ordinary Shares or Convertible Securities.


 


(viii) “Ordinary Share Equivalent
Price” means the quotient obtained by dividing (i) the Exercise Price in effect immediately prior to such issuance or sale
or deemed issuance or sale, divided by (ii) the rate of conversion of ADSs into Ordinary Shares in effect immediately prior to
such issuance or sale or deemed issuance or sale, and which shall initially be 40.


 



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(ix) “Trading Day” means any
day on which the ADSs are traded on the Trading Market, or, if the Trading Market is not the principal trading market for the ADSs,
then on the principal securities exchange or securities market on which the ADSs are then traded, provided that “Trading
Day” shall not include any day on which the ADSs are scheduled to trade on such exchange or market for less than 4.5 hours
or any day that the ADSs are suspended from trading during the final hour of trading on such exchange or market (or if such exchange
or market does not designate in advance the closing time of trading on such exchange or market, then during the hour ending at
4:00:00 p.m., New York time) unless such day is otherwise designated as a Trading Day in writing by the Holder.


 


(x) “Trading Market” means
NYSE MKT, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market or the New York Stock Exchange.


 


(xi) “VWAP” means, for any
date, the price determined by the first of the following clauses that applies: (a) if the ADSs are then listed or quoted a Trading
Market, the daily volume weighted average price of the ADSs for such date (or the nearest preceding date) on the Trading Market
on which the ADSs are then listed or quoted as reported by Bloomberg L.P. (based on a Trading Day from 9:30 a.m. (New York City
time) to 4:02 p.m. (New York City time)), (b) the volume weighted average price of the ADSs for such date (or the nearest preceding
date) on the OTC Bulletin Board, (c) if the ADSs are not then listed or quoted for trading on the OTC Bulletin Board and if prices
for the ADSs are then reported in the OTCQB maintained by OTC Markets Group, Inc. (or a similar organization or agency succeeding
to its functions of reporting prices), the the most recent bid price per ADS so reported , or (d) in all other cases, the fair
market value of an ADS as determined by an independent appraiser selected in good faith by the holders of a majority in interest
of the Warrants then outstanding and reasonably acceptable to the Company, the fees and expenses of which shall be paid by the
Company.


 



    	16



    	 



    






 


IN WITNESS WHEREOF, this Warrant Agreement
has been duly executed by the parties hereto as of the day and year first above written.


 





	 	 	BIONDVAX
PHARMACEUTICALS LTD.
	 	 	 
	 	 	By: 
	 	 	Name:
	 	 	Title:
	 	 	 
	 	 	Address
for notices:
	 	 	14 Einstein
Street
	 	 	Nes Ziona,
Israel 74036
	 	 	Attention:
	 	 	Telephone:
	 	 	Facsimile:
	 	 	E-mail:
	 	 	 
	 	 	 
	 	 	THE BANK
OF NEW YORK MELLON,
	 	 	As Warrant
Agent
	 	 	 
	 	 	By:
	 	 	Name:
	 	 	Title:



 





 


 


Annex A Form of Warrant Certificates


Annex B Election to Purchase


Annex C Authorized Representatives









    	17



    	 



    




ANNEX A


BIONDVAX PHARMACEUTICALS LTD.

WARRANT CERTIFICATE

NOT EXERCISABLE AFTER __________, 2019


This certifies that the person whose
name and address appears below, or registered assigns, is the registered owner of the number of Warrants set forth below. Each
Warrant entitles its registered holder to purchase from BiondVax Pharmaceuticals Ltd. (the “Company”) at any
time prior to 5:00 P.M. (New York City time) on _________, 2019, at the designated office of The Bank of New York Mellon, as warrant
agent (the “Warrant Agent”) set forth below, one American depositary share (each, an “ADS”),
each ADS representing 40 ordinary shares, nominal value NIS.000001 each, of the Company (each, a “Share” and
collectively, the “Shares”), at price of US$________. Exercising warrantholders will also be required to deposit
with the Warrant Agent $0.05 for each new ADS (the “Issuance Fee”) to pay the issuance fees of the Depositary.


This Warrant Certificate, with or without
other Warrant Certificates, upon surrender at the designated office of the Rights Agent, may be exchanged for another Warrant Certificate
or Warrant Certificates evidencing the same number of Warrants as the Warrant Certificate or Warrant Certificates surrendered.
A transfer of the Warrants evidenced hereby may be registered upon surrender of this Warrant Certificate at the designated office
of the Warrant Agent by the registered holder in person or by a duly authorized attorney, properly endorsed or accompanied by proper
instruments of transfer, a signature guarantee, and such other and further documentation as the Warrant Agent may reasonably request
and duly stamped as may be required by the laws of the State of New York and of the United States of America.


The terms and conditions of the Warrants
and the rights and obligations of the holder of this Warrant Certificate are set forth in an ADS Warrant Agreement dated as of
______, 2015 (the “Warrant Agreement”) between the Company and the Warrant Agent. A copy of the Warrant Agreement
is available for inspection during business hours at the office of the Warrant Agent.


This Warrant Certificate shall not be
valid or obligatory for any purpose until it shall have been countersigned by an authorized signatory of the Warrant Agent.


WITNESS the facsimile signature of a
proper officer of the Company.





		 	BIONDVAX
PHARMACEUTICALS LTD.
	 	 	 
	 	 	By: 
	 	 	Name:
	 	 	Title:
	 	 	 
	 	 	
	Dated:	 	
	Countersigned:		
	 		
	THE BANK OF NEW YORK MELLON,	 	
	as Warrant Agent		
	 	 	
	By:	 	
	Name:	 	 
	Title:	 	
	 	 	
	 	 	 
	 	 	
	 		
	 	 	



 



PLEASE DETACH HERE


 







    	18



    	 



    




Certificate No.:_________ Number of Warrants:__________


WARRANT CUSIP NO.: ________


BIONDVAX PHARMACEUTICALS LTD.


 


	[Name & Address of Holder]	THE BANK OF NEW YORK MELLON, Warrant Agent
	 	
        By mail:

        The Bank of New York Mellon

        c/o Voluntary Corporate Actions

        PO Box 43011

        Providence, RI  02940-3011

         

        By hand or overnight courier: 

        The Bank of New York Mellon

        c/o Voluntary Corporate Actions

        250 Royall St, Suite V

        Canton, MA  02021

         

         



 









    	19



    	 



    

 





[Form of Election to Purchase]


(To Be Executed Upon Exercise Of Warrants)


The undersigned hereby irrevocably elects
to exercise the right, represented by Warrants evidenced by this Warrant Certificate, to receive                 
ADSs and herewith tenders payment for such ADSs to the order of The Bank of New York Mellon, in the amount of $             
in accordance with the terms hereof.


OR


The undersigned hereby irrevocably elects
to exercise the right, represented by Warrants evidenced by this Warrant Certificate, to receive               
ADSs (before giving effect to the cashless exercise provisions) and herewith agrees to make payment therefor pursuant to the cashless
exercise provisions of the Warrant Agreement, all on the terms and the conditions specified in the Warrant Agent Agreement.


The undersigned requests that a certificate
for such ADSs be registered in the name of                     ,
whose address is                     
and that such certificate be delivered to                     ,
whose address is                                         .
If the number of Warrants being exercised hereby is less than all the Warrants evidenced by this Warrant Certificate, the undersigned
requests that a new Warrant Certificate representing the remaining unexercised Warrants be registered in the name of                                         ,
whose address is                                         ,
and that such Warrant Certificate be delivered to whose address is                                         .


 


	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	Signature
	 	 	 
	Date:	 	 	 	 
	 	 	 
	 	 	 	 	 
	 	 	 	 	Signature Guaranteed





Signatures must be guaranteed by an “eligible guarantor
institution” meeting the requirements of the Warrant Agent, which requirements include membership or participation in the
Security Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program” as may
be determined by the Warrant Agent in addition to, or in substitution for, STAMP, all in accordance with the Securities Exchange
Act of 1934, as amended.


 


 


2020