UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

'JUL 1 5 2011 

MEMORANDUM 

OFFICE OF CHEMICAL SAFETY 

AND POLLUTION PREVENTION 

SUBJECT: BEAD Chemical Profile for Registration Review: Acetaminophen (109509) 

FROM: 

THRU: 

TO: 

Colwell Cook, Entomologist d~ Biological Analysis Branch 

Sepehr Haddad, Environmental Protection Specialist 

Science Information and Analysis Branch 

Michelle Ranville, Economist Lf}LCAC) Economic Analysis Branch 

Biological and Economic Analysis Division (7503P) 

ArnetJones, Chief /) ""J~ Biological Analysis Branc~ ""U 

Diann Sims, Chief ~~ pM,[) 

Science Information and Analysis Branch 

Timothy 

Economic 

Kiely, 

Analysis 

Chief 

Branch ~ VV\. ~ 

Biological and Economic Analysi ivision (7 ) 

Bonnie Adler, Chemical Review Manager 

Risk Management and Implementation Branch 5 

Pesticide Reevaluation Division (7508P) 

Product Review Panel date: July 13, 2011 

INTRODUCTION 

The purpose of this document is to convey usage information and a broad overview of the pest 

management roles of pesticides that are beginning to undergo registration review. The 

anticipated audience consists of the team of EPA staff currently evaluating the registration status 

of acetaminophen, and eventually the general pUblic. This document builds upon the data already 

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provided in the "Usage and Label Use Data Packages" that are also provided to Registration 

Review teams by BEAD. The document is based on information and data available to BEAD as 

of June 2011. 

Acetaminophen (the same ingredient found in Tylenol®) is an analgesic and antipyretic drug for 

humans, and sometimes considered to be a non-steroidal anti-inflammatory drug. It was found to 

be toxic to the brown tree snake, Boiga irregular is, an invasive species currently in Guam. The 

exact mode of action is unknown. Acetaminophen was registered for brown tree snake control in 

February 2004 in an application by the USDA APHIS. 

The brown tree snake is an introduced, invasive species in Guam. It is mildly venomous, fairly 

aggressive, and a dietary generalist that have decimated many native bird species on Guam. This 

pesticide is one part of an IPM program developed by the United States Department of 

Agriculture Wildlife Services to reduce the populations of brown snakes. (Johnson, et al., 2002) 

USE SITES 

NOD- Agricultural Usage 

Acetaminophen for brown tree snake control is labeled for use in non-crop areas in and around 

military bases, airports, shipping ports, and other areas where brown tree snakes may be present. 

This registration is for use only by employees of the U.S. State and Federal governments, 

Government of Guam or the Commonwealth of Northern Mariana Islands trained in brown 

tree snake control. 

COMMON FORMULATIONS AND APPLICATION METHODS 

Acetaminophen is formulated as a pelletted solid only. Bait preparation is by manually inserting 

one 80 mg or two 40 mg acetaminophen tablets into the throat of a dead mOuse pup (approximate 

age: 10-15 days). Baits may be broadcast or dropped from helicopters and fixed wing aircraft:. 

BIOLOGICAL ASPECTS RELEVANT TO ACETAMINOPHEN 

There are no other uses of acetaminophen as a pesticide, and the dose used is equivalent to the 

children's dose. Therefore, BEAD does not foresee are any issues concerning resistance, plant 

health claims, or public health issues. 

HISTORY OF BEAD ASSESSMENTS FOR ACETAMINOPHEN 

No other BEAD assessments were found in the official records. 

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REFERENCES 

J. J. Johnston, P. J. Savarie, T. M. Primus, J. D. Eisemann, J. C l-Iurley, and D. J. Kohler 

Environ. Sci. Technol., 2002, 36 (17), pp 3827-3833 

Risk Assessment of an Acetaminophen Baiting Program for Chemical Control of Brown Tree 

Snakes on Guam: Evaluation of Baits, Snake Residues, and Potential Primary and 

Secondary Hazards 

http://pubs.acs.org/doi/fullli 0.1 021/esO 15873n 

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