UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM 

Date: April 9, 2014 

SUBJECT: Dipropyl Isocinchomeronate (MGK-326): Tier I Review of Human Incidents 

PC Code: 047201 OP Barcode: 0419225 

Decision No.: 489507 

Petition No.: NA 

Risk Assessment Type: NA 

TXR No.: NA 

MRID No.: NA 

Registration No.: NA 

Regulatory Action: NA 

Case No.: NA 

CAS No.: 136-45-8, 3737-22-2 

40CFR: NA 

FROM: Shanna Recore, Industrial Hygienist 

Toxicology and Epidemiology Branch 

Health Effect Division (7509P) 

Ver.Apr.08 

Toxicology 

Elizabeth and Evans, 

and Epidemiology 

Environmental 

Bran

Protection 

ch 

Specialist ~ 

v-Cf" _ .~ ~ 

Health Effects Division (7509P) /J :j} 

THROUGH: David Miller, Acting Branch Chief 1\__p,) f}tp~~ ~ Toxicology and Epidemiology Branch {)';..1o 1 

Health Effects Division (7509P) 

TO: Thurston Morton, Risk Assessor 

Risk Assessment Branch IV 

Health Effects Division (7509P) 

and 

Mo!Jy Clayton, Chemical Review Manager 

Risk Management & Implementation Branch 3 

Pesticide Re-evaluation Division (7508P) 

Summary and Conclusions 

Based on the low severity of incident cases reported for dipropyl isocinchomeronate in both IDS 

and SENSOR-Pesticides, there does not appear to be a concern at this time that would warrant 

further investigation. The Agency will continue to monitor the incident information and if a 

concern is triggered, additional analysis will be included in the risk assessment. 

Page 1 of 10 
Detailed Review 

I. ACTION REQUESTED 

This review is intended to fulfill our requirement to docket summaries of incident data that were 

reported to the Agency, as well as to ensure human incident data and the Agricultural Health 

Study (AHS) are part of the problem formulation phase of registration review. Reports of 

adverse health effects allegedly due to a specific pesticide exposure (i.e. , an "incident") are 

largely self-reported and therefore, generally speaking, neither exposure to a pesticide or 

reported symptom (or the connection between the two) is validated or otherwise confirmed. 

Typically, causation cannot be determined based on incident data. However, incident 

information can be an important source of feedback to the Agency: incidents of severe outcome, 

or a suggested pattern or trend among less severe incidents, can signal the Agency to further 

investigate a particular chemical or product. Observational epidemiology studies relate the risk 

of disease, e.g., cancer, and exposure to an agent such as a pesticide product in the general 

population or specific sub-groups like pesticide applicators. 

II. BACKGROUND 

Dipropyl isocinchomeronate is an insect repellent. It is never used as the sole active ingredient 

(a.i). Rather, it is used to expand the spectrum of repellency of other formulation components. 

Dipropyl isocinchomeronate can be applied to cats (adults/kittens), dogs/canines 

(adults/puppies), human body/clothing, horses (not intended for food), pet living/sleeping 

quarters. 1 

For this evaluation, both the OPP Incident Data System (IDS) and the Centers for Disease 

Control and Prevention/National Institute for Occupational Safety and Health (CDC/NIOSH) 

Sentinel Event Notification System for Occupational Risk-Pesticides (SENSOR) databases were 

consulted for pesticide incident data on the active ingredient dipropyl isocinchomeronate (pc 

code: 047201). The purpose of the database search is to identify potential patterns in the 

frequency and severity of the health effects attributed to dipropyl isocinchomeronate exposure. 

Dipropyl isocinchomeronate is not included in the AHS, and therefore this study does not 

provide information for this report. 

III. RESULTS/DISCUSSION 

a. IDS (Incident Data System) 

OPP's IDS includes reports of alleged human health incidents from various sources, including 

mandatory Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) Section 6(a)(2) reports 

from registrants, other federal and state health and environmental agencies, and individual 

consumers. Since 1992, OPP has compiled these reports in IDS. IDS contains reports from 

across the U.S. and most incidents have alJ relevant product information recorded. Reports 

1 http://www.epa.gov/oppOOOO I /chem_search/reg_actions/reregistrationlred _PC-04 720 1_23-Sep-03.pdf 

Page 2 of 10 
submitted to the IDS represent anecdotal reports or allegations only, unJess otherwise stated in 

the report. 

IDS records incidents in one oftwo modules: Main IDS and Aggregate IDS: 

o Main IDS contains incidents resulting in higher severity outcomes and provides 

more detail with regard to case specifics. This system stores incident data for 

death, major and moderate incidents, and it includes information about the 

location, date and nature of the incident. Main IDS incidents involving only one 

active ingredient (as opposed to pesticide products with multiple active 

ingredients) are considered to provide more certain information about the 

potential effects of exposure from the pesticide. 

o Aggregate IDS contains incidents resulting in less severe human incidents (minor, 

unknown, or no effects outcomes). These are reported by registrants only as 

counts in what are aggregate summaries. 

As previously stated, dipropyl isocinchomeronate is never used as the sole active ingredient and 

is always co-formulated in pesticide products. As expected, for the Main IDS, from January 1, 

2009 to March 5, 2014, there were no incidents reported for single chemical only in the database. 

There were 26 incidents reported involving more than one chemical. Twenty five incidents were 

classified as moderate severity. Of these, two incidents were suicide attempts and one incident 

was a duplication. One incident was classified as major severity. A 54 year old female got less 

than 1 tsp. of the product on her hand while transferring the product from a refill bottle into a 

spray bottle. She experienced an allergic reaction. The remaining narratives are summarized in 

Appendix 1. 

In Aggregate IDS, from January 1, 2009 to March 5, 2014, there were 449 incidents reported 

involving dipropyl isocinchomeronate. One hundred seventy nine incidents were classified as 

unknown or no effects and 270 incidents were classified as minor severity. 

Most (95%) of the incidents reported to IDS involving dipropyl isocinchomeronate were either 

minor severity (n=270) or no or unknown effects (n=179). For the minor incidents, this means 

that a person alleged or exhibited some symptoms, but they were minimally traumatic, the 

symptoms resolved rapidly and usually involved skin, eye or respiratory irritation. For the 

no/unknown effects, this mean that symptoms are unknown, unspecified or are alleged to be of 

delayed or chronic nature that may appear in the future. 

The most often implicated product in both Main and Aggregate IDS is Reg. No. 270-343 (Adams 

Flea and Tick Mist). In addition to containing 0.5 % dipropyl isocinchomeronate, this product 

also contains pyrethrins (0.15%), piperonyl butoxide (1.50%) and n-octyJ bicycloheptene 

dicarboximide (0.5%). It was implicated in 73% of the dipropyl isocinchomeronate incidents 

reported to IDS. This may be potentially attributable to high use of this product by consumers. 

Obtaining additional information on current usage data for dipropyl isocinchomeronate would 

improve future assessments. Adams Flea and Tick Mist is used by homeowners on horses, dogs, 

puppies, cats, and kittens to kill fleas, ticks, and lice and to repel flies, gnat, and mosquitoes. 

Page 3 of 10 
This product label instructs users to rub the product in to pets' fur with their hands leading to 

dermal exposure. 

b. SENSOR-Pesticides 

The SENSOR-Pesticides database covers 11 states from 1998-2010, although reporting varies 

from state to state. Cases of pesticide-related illnesses are ascertained from a variety of sources, 

including: reports from local Poison Control Centers, state Department of Labor workers' 

compensation claims when reported by physicians, reports from State Departments of 

Agriculture, and physician reports to state Departments of Health. Although both occupational 

and non-occupational incidents are included in the database, SENSOR-Pesticides focuses on 

occupational pesticide incidents, and is of particular value in providing that information. The 

state coordinator at each of the 11 respective state Departments of Health conducts case followup activities such as obtaining medical records to verify symptoms and severity. Using 

standardized protocol and case definitions derived from poison center reporting, the state 

SENSOR-Pesticide coordinator enters the incident information into the state-based system which 

is sent to NIOSH annually to be aggregated. 

A query of SENSOR-Pesticides from 1998-2010 identifies 73 cases involving dipropyl 

isocinchomeronate (pc code 047201). All cases involve multiple active ingredients. Only 8 

cases were work-related, 40 cases were not work-related and 25 cases were unknown with 

regards to whether or not it was work-related. Cases involved either insect repellents or flea/tick 

pet products. Thirty two cases involved children under age 12. Twenty of these cases involved 

the child getting the product sprayed in their face/eye. 

Two cases were high in severity, three cases were moderate in severity, and 68 cases were low in 

severity. One high severity case involved intentional ingestion of the product and the second 

high severity incident involved application to open wounds. The high and moderate severity 

cases are summarized in Tablel . 

Table 1. SENSOR-Pesticides 1998-2010 

High & Moderate Dipropyl Isoincbomeronate Case Descriotions 

m I Severity I Year I Case Description 

NY00695 

FL00261 

TXOI609 

OROI1 15 

NM00022 

High 

High 

Moderate 

Moderate 

Moderate 

2003 

1998 

1999 

2004 

2005 

According to chart, mother reports patient ingested unknown. amount of Wellbutrin 

and Wipe On for horses insecticide. 

Complainant had fire ant bites on his legs when he applied product. Open wounds 

provided direct route of entry to bloodstream 

Case licked arms that had insect spray on them. Later mother noticed case had 

twitching of eye and neck muscles. 

Closed container over pressurized in aircraft resulting in exposure to pilot 

Case reported that he was sprayed with fly-foil spray when fly-foil spray was being 

applied to a truck full of onions. 

Route of Exposure and Symptoms 

The most common route of exposure reported was ocular (n=41); followed by dermal (n=26). 

The symptoms reported reflects this as well with ocular symptoms (such as redness and 

irritation) being the most common (n=44) followed by dermal symptoms (n=22). A summary of 

symptoms reported is provided in Table 2. 

Page 4 of 10 
Table 2. SENSOR-Pesticides 1998-2010: Reported 

Health Effects for Dipropyl lsoinchomeronate 

N=73 

Health Effect # of Times Reported 

Dermal 22 

Ocular 44 

Respiratory 13 

Gastrointestinal 10 

Renal 0 

Nervous System 13 

Cardiovascular I 

* Case-S may repon multiple health effects 

c. Agricultural Health Study (AHS) 

The AHS is a high quality, prospective epidemiology study evaluating the link between pesticide 

use and various health outcomes including cancer. The AHS includes private and commercial 

pesticide applicators and their spouses. Ifthere are AHS findings relevant to a particular 

pesticide going through registration review, the Agency will ensure they are considered in the 

problem formulation/scoping phase of the process and, if appropriate, fully reviewed in the risk 

assessment phase of the process. The AHS includes information on use of 50 different pesticide 

active ingredients commonly used in agriculture. Dipropyl isocinchomeronate is not included in 

the AHS, and therefore this study does not provide information for this report. 

IV. CONCLUSION 

Based on the low severity of incident cases reported for dipropyl isocinchomeronate in both IDS 

and SENSOR-Pesticides, there does not appear to be a concern at this time that would warrant 

further investigation. The Agency will continue to monitor the incident information and if a 

concern is triggered, additional analysis will be included in the risk assessment. 

Page 5 of 10 
A ppen d. I M . IDS M . S tx am a1or even t I .d ry net ent D escnp110n or 1propy1 I I socmc h omeronate. 

Human Incident I Chemical: Dipropyl isocinchomeronate I PC Codes: 116001, 116002, 116004 

Incident 

Package Incident Reg 

Report Date Location Number Product Name Incident Description 

A 50 year old male has been using product on his bed for about three 

weeks and is now feeling sick. About three days ago, he began having 

some shakiness, nausea, bronchitis and lhe bottom half of his body is 

020736- 000270- ADAMS FLEA numb. He does not have any skin irritation. He was in a very bad car 

00004 1/ 14/2009 TAMPA, FL 00343 AND TICK MIST accident a few years ago and is onprescription morphine for the pain. 

A 54 year old female caller got less than I tsp. of product on her hand 

while transferring a refill bottle of product into a spray bottle. She rinsed 

her hand off with a hose and sprayed three horses with the product. 

While preparing to take a shower, she felt like she had "thousands of 

bugs under her skin" and started to swell rapidly. She scrubbed hands 

and feet with soap. She called 911 and told them she was having an 

allergic reaction. While waiting for the ambulance she passed out. When 

FLYSECT she woke she was vomiting and continued to vomit in the ambulance. 

SUPER-7 She was given an Epi-Pen in the ambulance. She also experienced 

021149- 000270- REPELLENT hypotension. She was given IV steroids. She was instructed to take 

0000 1 7/ 16/2009 VA 00300 SPRAY Zantac twice daily and Benadryl three times per day. 

A 42 year old male laid on a couch that had been sprayed with product 

before it was dry. He was admitted to the hospital with sudden memory 

loss, shaking, and arms and legs drawn up. He was on breathing tube due 

to seizure-like symptoms. He recognized family but didn't know address 

for two days. He was rambling and incoherent. He had been on 

antidepressants and Fentanyl prior to hospitalization. All testing, 

toxicology, MRl's came back normal. Meds were reduced. He gradually 

improved and was released from the hospital, after 4 days. His memory 

was back to normal, but it was hard for him to control his hand and 

021215 - 000270- ADAMS FLEA& write. He came home and rested on couch per instructions. He still talks 

0000 1 7/27/2009 IL 00343 TICK MIST incoherently, experiences has double vision and headaches. 

An adult female used the product, along with another flea & tick spray, 

in tbe house. Three days later, she feels "out of it" and experienced 

headache, chest pain, shortness of breath, and nausea. She works at a 

021312- 000270- ADAMS FLEA clinic where they took her BP and said it low and she was not a llowed to 

00001 9/9/2009 wv 00343 AND TICK MIST drive home. She feels like she can taste the product. 

Page 6 of 10 
Human Incident I Chemical: Dipropyl isocinchomeronate I PC Codes: 116001, 116002, 116004 

incident 

Package Incident Reg 

Report Date Location Number Product Name Jncident Description 

Caller applied product to dog and allowed it to dry. An hour later, her 

ADAMS FLEA child (2 year old female) played with dog. About 4 hours later, the caller 

021429- BONNE TERRE, 037425- AND TICK MIST noted welts on the child's arms, legs and flanks. The child was given a 

00004 10/26/2009 MO 00012 320Z bath; welts resolved but skin still has redness. 

A 34 year old male used the product 48 hours ago spraying the product 

onto his hands and rubbing his hands on his face (per label). The product 

001021- COLEMAN was also applied to his arms and legs. The caller states yesterday evening 

021934- 01600- INSECT he developed raised fluid filled blisters on his face and neck. His arms 

00002 4/5/2010 ASHEVILLE, NC 079533 REPELLENT am/legs appear normal. 

FLYSECT An adult female had water-diluted product on her bare hands, wiping 

SUPER-C down the cows' faces two days ago. She was in today for a recheck om a 

022013- BROOKSVILLE, 000270- REPELLENT chronic viral illness (for which she's taking ABX) and the HCP found 

00001 5/Jl/2010 FL 00301 CONCENTRATE that she had elevated liver enzymes. No irritation or paraesthesia 

Caller states that the product has been used frequently on five. dogs. She 

holds the dogs while her husband sprays them. She has had skin contact 

with product two times. Since she started using the product she 

experienced chest pain and difficulty breathing. The symptoms have 

ADAMS FLEA& been intermittent and she thinks they started the same day she used the 

022013- 000270- TICK MIST 16 product. She was seen in ER since symptoms started. She has restarted 

00002 5/14/2010 TX 00343 oz medication for high blood pressure (Norvasc 5 mg), 

PREVENT! An adult fema le noticed that the product leaked out of the can and mixed 

MOSQUITO with several soaps and cleaning products under her sink. While cleaning 

001021- REPELLENT the spill she suspects the mixture may have contacted her hands. 

022233 - BIRMINGHAM, 01600- CONTAINS Approximately 3 days later she developed slurred speech, confusion and 

00004 7/5/2010 AL 059144 DEET25% it felt like her 'heart was racing.' 

A 6 year old male child broke out in red raised bumps that cover his 

arms and legs. The child's mother sprayed her home with two products 

022306- BLOOMINGTON, 000270- ADAMS FLEA and the child broke out a few hours later. Unsure if the child was in the 

00009 811112010 IL 00343 AND TICK MIST home during the application. The red bumps are not itchy. 

A parent sprayed the product on his 2 year old son. Four hours later, his 

son developed a temp of 102 and has a red rash on his neck and arms. 

011715- CRCDOUBLE They ended up taking child to ER. The symptoms were not from the 

022306- 00085- INSECT product but most likely from a virus. He also developed diarrhea. He 

0001 3 8/ 19/2010 TX 055809 REPELLENT was put on an antibiotic. 

Page 7 of 10 
Human lncident I Chemical: Dipropyl isocinchomeronate I PC Codes: 116001 , 116002, 116004 

Incident 

Package lncident Reg 

Repo1·t Date Location Number Product Name fncident Description 

An adult female used product on her dogs about ten hours ago. She 

ADAMS FLEA& rubbed it in with her hands but washed them with soap and water after. 

022308- 000270- TICK MIST 16 FL She has developed symptoms of nausea, chills, headache and anorexia 

00004 8/22/2010 OK 00343 oz and they are getting worse. 

Caller used product and later on that day her grandson (4 years old) was 

playing on the carpet and broke out in hives and a rash all over his body. 

ADAMS FLEA & They took the child to the doctor and were given some Benadryl and HC 

022308- 037425- TICK MIST 16 FL cream to use. Symptoms are slowly getting better and the carpet was 

00005 8/19/2010 IL 00012 oz shampooed yesterday. 

A 62 year old male experienced puffy eyes and nausea. He reports that 

when he was trying to spray his dog yesterday, it resisted and some of 

the spray got on his hands and on his face. He washed with soap and 

water. He not flush his eyes as he did not get any of the product in them. 

ADAMS FLEA He experienced muscle tightness in his neck and shoulders after the 

022308- 000270- AND TICK MIST exposure occurred. He took an ibuprofen after and slept for 45 minutes, 

00006 8/24/2010 MI 00343 32 FLOZ but woke up and did oot feel better. 

A 24 year old female handled the product on and offfor years without a 

problem. She applied the product daily to the dog until she bad two 

seizures at work. She went to ER, where she had fo ur more seizures. 

They gave her a valium prescription and she saw a neurologist the next 

day, who gave her Tegretol. The neurologist said the description of the 

seizures made him sure they were partial seizures. Patient had a 

nosebleed and three more seizures. The doctor changed her prescription 

FL YS-OFF FLY to Kepra. She had been applying the product quite heavily. The dog 

022308- 000270- REPELLENT started having seizures too. Patient is under the care of a physician and 

00007 8/6/2010 ST. JOSEPH, MO 00103 OINTMENT 5 OZ diagnosed with partial seizure disorder. 

An adult female sprayed product on her dogs. That night she broke out 

in itchy hives. She says she started to take Benadryl but her symptoms 

have gotten worse. She has used this product before with no reaction. 

Three days later, she was covered in hives. Her lips, tongue and mouth 

ADAMS FLEA & started to fee l numb. She went to the ER and was treated with steroids 

022308 - 000270- TICK MIST 16 FL and some other medications. Symptoms are improving now: No specific 

00008 8/27/20 10 MI 00343 oz cause found for symptoms but she relates it to product use. 

022385- 91!4/2010 FORT WORTH, 000270- ADAMS FLEA & Caller's husband used product in the house last night and while he was 

Page 8 of 10 
Human Incident I Chemical: Dipropyl isocinchomeronate I PC Codes: 116001,116002, 116004 

Incident 

Package Incident Reg 

Report Date Location Number Product Name Incident Description 

00001 TX 00343 TICK MIST 16 FL spraying the odor became very strong and she developed a sore throat 

oz and hard coughing and asked him to stop spraying. In the morning she 

vomited, felt cold, had increased urination and abdominal pain below her 

ribs. She has severe allergies, especially to some antibiotics, and she is 

asthmatic. She can still smell the product in the home and she is 

extremely sensitive to odors. She went to a HCP who gave her an 

antiemetic and other meds. She mentioned she developed a high fever 

followed by being ice cold after her exposure to the product. For the 2nd 

and 3rd day she mainly had nausea and a little diarrhea. 

A 59 year old male used the product and within 24 hours he developed 

001021- BENGAL lower back pain. He was evaluated by the MD and was told he had a 

022492 - WEST MONROE, 01600- MOSQUITO pinched sciatic nerve. He was prescribed an anti-inflammatory 

00003 9/14/2010 LA 068543 REPELLENT medication and an antibiotic and given an injection. 

A 33 year old female used both products on her dogs in the morning and 

late afternoon she developed an itchy rash on both arms from her wrist to 

elbow. Both arms were exposed to the product. She washed her arms off. 

022677- 000270- ADAMS FLEA& She applied HC cream and took Benadryl and it temporarily helped her 

00004 1/4/2011 GA 00343 TICK MIST symptoms. 

Product was sprayed on caller's 7 year old daughter's arms and legs. She 

001021- PREVENT! developed a small rash that spread to her arms and legs. One leg feels 

023098- 01600- MOSQUITO warm and is swollen. She went to the doctor and was prescribed l% 

00005 6/l8/2011 CUMMING,GA 059144 REPELLENT hydrocortisone. She was not improving at the time of the call. 

An adult female states that about haifa bottle was used on floor for a 

black ant invasion. Doors and windows were open for ventilation when 

ADAMS FLEA& used. Two hours later, she experienced voice hoarseness and sore throat. 

023241 - 000270- TICK MIST 16 A 24-year-old male in the home is spitting up bright red . He was 

00003 7/4/2011 NM 00343 oz sleeping when the product was used. 

A 53 year old male used the product several times over the last week or 

001021- ZEPSTA-A-WAY so, and he developed a red rash on his legs and forearms. His physician 

023329- 01600- INSECT recommended that he take Prednisone to treat his symptoms, but he 

00004 817/2011 BUFFALO, NY 001270 REPELLENT reports that his symptoms have not dissipated. 

ADAMS PLUS A 29 year old female dipped her dog with diluted product. Unknown if 

023534 - 000270- PYRETHRIN DIP she was wearing gloves or not. The next day, she developed breathing 

00002 10/1/2011 NICEVILLE, FL 00349 40Z problems. Three days later, she developed symptoms of pneumonia. She 

Page 9 of 10 
Human Incident 

I 

Chemical: Dipropyl isociochomeronate I PC Codes: 116001, JJ6002, 116004 

Incident 

Package Incident Reg 

Report Date Location Number Product Name Incident Description 

was admitted to the hospital from the ER as the pneumonia became 

worse. She was put on antibiotics and IV fluids and unknown other 

meds. She developed hypercalcemia and the levels were dropping. Dog 

became sick as well and has been to the vet for treatment. NAPCC rep 

told caller that dog's symptoms were not typical for the product. 

Daughter is also being treated for thyroid cancer. 

Page 10 of 10