Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

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Page 2 of 18

Executive Summary

At the request of Registration Division, an acute and chronic dietary risk assessment for 

flumioxazin was conducted using the Dietary Exposure Evaluation Model (DEEM-FCID, 

Version 2.03) which uses food consumption data from the U.S. Department of 

Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-

1996 and 1998. This analysis was performed to estimate the acute and chronic dietary 

(food and drinking water) risk resulting from current and new uses of flumioxazin on 

field pea, flax, lentil, sunflower, safflower, and wheat commodities

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

An unrefined, acute dietary exposure assessment using tolerance levels, processing 

factors, and assuming 100% crop treated (CT) for the proposed commodities was 

conducted for the general U.S. population and various population subgroups. The 

estimated drinking water concentration of flumioxazin was provided by the 

Environmental Fate and Effects Division (EFED) and incorporated directly into the acute 

assessment. An estimated environmental concentrations (EECs) for flumioxazin and its 

major degradates (482-HA and APF) under the use as an aquatic herbicide of 400 ppb 

was estimated for acute exposure.

There were no appropriate toxicological effects attributable to a single exposure (dose) 

for the general population or any other population subgroups except females 13-49 years 

old; therefore, these population subgroups were not included in this assessment. For food 

and drinking water, the acute dietary risk estimate is below HED’s level of concern 

(<100% of the acute population adjusted dose (aPAD)) at the 95th percentile of exposure. 

The acute dietary exposure estimate for females 13-49 years old is 0.020349 mg/kg/day 

(68% of the aPAD).

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

The chronic dietary exposure and risk estimates are conservative since they assume that 

100% of crops are treated, processing factors, and that the residues are present at the 

tolerance levels. The EECs for flumioxazin and its major degradates (482-HA and APF) 

under the use as an aquatic herbicide is 142 ppb. Combined chronic dietary exposure 

estimates for food and drinking water are well below HED’s level of concern. Using the 

DEEM-FCID software, dietary exposure is estimated at 0.003976 mg/kg/day for the 

general U.S. population, which is equivalent to 20% of the chronic Population Adjusted 

Dose (cPAD), and 0.010863 mg/kg/day, equivalent to 54% of the cPAD for all infants (< 

1year old), the population subgroup with the highest estimated chronic dietary exposure 

to flumioxazin.
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

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Page 3 of 18

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

Flumioxazin is classified as a “Not likely to be carcinogenic to humans.” Therefore, a 

cancer dietary exposure analysis is not required. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. 

For acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose. This is the population adjusted dose (PAD), which HED has 

concluded will result in no unreasonable adverse health effects. The PAD is the 

Reference Dose (RfD) divided by the FQPA Safety Factor. Dietary risk is expressed as 

a percentage of the PAD. For acute and non-cancer chronic exposures, HED is 

concerned when estimated dietary risk exceeds 100% of the PAD. References which 

discuss the acute and chronic risk assessments in more detail are available on the 

EPA/pesticides web site: “Available Information on Assessing Exposure from 

Pesticides, A User’s Guide”, 6/21/2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 

(8/20/99).

The most recent dietary risk assessment for flumioxazin was conducted by W. Cutchin, 

DP#379036, 6/16/10.

II. Residue Information

Flumioxazin belongs to the N-phenylphthalimide class of herbicides (Group 14) and is 

currently registered for pre- and post-emergence applications on a variety of fruit, 

vegetable, and field crops for the control of susceptible weeds. Tolerances are currently 

established for residues of the herbicide flumioxazin in/on various plant commodities, at 

levels ranging from 0.02 to 8.0 ppm (as listed in e-CFR 40 §180.568[a], updated April, 

2012).

The residue of concern for both the tolerance expression and risk assessment in plants is 

flumioxazin. No livestock tolerances have been established. A tolerance for combined 

residues of flumioxazin and its metabolites APF (3-oxo-4-prop-2ynyl-6-amino-7-fluoro3,4-dihydro-1,4-benzoxazin) and 482-HA (N-(7-fluoro-3,4-dihdyro-3-oxo-4-prop-2-ynyl2H-1,4-benzoxazin-6-yl)cyclohex-1-ene-1-carboxamide-2-carboxylic acid) in freshwater 

fish.

The proposed use and the submitted data support the following tolerances for residues of 

flumioxazin in/on the following commodities:

Pea and bean, dried shelled, except soybean, subgroup 6C....................... 0.07 ppm

Rapeseed subgroup 20A ............................................................................ 0.40 ppm

Sunflower subgroup 20B ........................................................................... 0.50 ppm
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

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Page 4 of 18

Wheat, grain............................................................................................... 0.40 ppm

DEEM 7.81 processing factors were used for all processed commodities, with the 

exception of tomato which used the empirical processing factor of one. A tomato 

processing factor of 1 is based on an exaggerated (~5x) crop field trial study in which no 

residues were recovered; therefore, a processing study is not required 

(47005106.der.com, D. Rate, 6/19/07). 100%CT was assumed for all commodities in this 

assessment. 

III. Drinking Water Data

References: Drinking Water Assessment for a Section 3 New Use for Flumioxazin EndUse Products Chateau WDG and Valor WDG Applications to Wheat, Sunflower, 

Safflower, Flax, Lentils, and Field Peas, D392618, Larry Liu, 3/21/2012.

A Tier I screening level drinking water assessment was conducted to support the human 

health risk assessment for the proposed new use for field pea, flax, lentil, sunflower, 

safflower, and wheat. The previous drinking water assessment (D379036, W.Cutchin, 

6/16/10) for use of flumioxazin on cotton, almonds, grapes, Christmas trees, deciduous 

trees and container and field grown ornamentals can be used for the currently proposed 

uses of Chateau WDG and Valor Herbicides. Since the maximum single application rate 

for the proposed uses (0.1 lb ai/A) is lower than the maximum single application rate 

(0.38 lb ai/A) used in the previous drinking water assessment. Also, the maximum 

yearly/seasonal application rate for the proposed uses (0.1 lb/A/year) is lower than the 

maximum yearly/seasonal application rate (0.76 lb/A/year) used in the previous drinking 

water assessment. Water residues were incorporated in the DEEM-FCID into the food 

categories “water, direct, all sources” and “water, indirect, all sources.” 

The EECs for flumioxazin and the metabolites 482-HA and APF are the residues of 

concern in drinking water. In order to be conservative, EECs for flumioxazin and its 

major degradates (482-HA and APF) as a result of the use as an aquatic herbicide of 

0.400 ppm (peak day-0) for acute exposure and of 0.142 ppm (30-days) for chronic 

exposure were used in the dietary analyses. Table 1 lists degradates identified and their 

relative concentrations. The model and its description are available at the EPA internet 

site: http://www.epa.gov/oppefed1/models/water/.

Table 1. EECs (ppb) From the Subsurface Application of Flumioxazin as an 

Aquatic Herbicide

Compound Peak EEC (Day 0) EEC at Days 30 and 

after1

Flumioxazin 400 10.4

482-HA - 21.6
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

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Page 5 of 18

APF - 110.1

THPA - 88.9

1 Total EEC = Sum of Flumioxazin + 482-HA + APF

IV. DEEM-FCIDTM Program and Consumption Information

Flumioxazin acute and chronic dietary exposure assessments were conducted using the 

Dietary Exposure Evaluation Model software with the Food Commodity Intake Database 

(DEEM-FCIDTM, Version 2.03), which incorporates consumption data from USDA’s 

Continuing Surveys of Food Intakes by Individuals (CSFII), 1994-1996 and 1998. The 

1994-96, 98 data are based on the reported consumption of more than 20,000 individuals 

over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked 

to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population 

subgroups, but for acute exposure assessment are retained as individual consumption 

events. Based on analysis of the 1994-96, 98 CSFII consumption data, which took into 

account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-

19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cPAD. This procedure is performed for each 

population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on 

an individual-by-individual basis. The reported consumption amounts of each food item 

can be multiplied by a residue point estimate and summed to obtain a total daily pesticide 

exposure for a deterministic exposure assessment, or “matched” in multiple random 

pairings with residue values and then summed in a probabilistic assessment. The 

resulting distribution of exposures is expressed as a percentage of the aPAD on both a 

user (i.e., only those who reported eating relevant commodities/food forms) and a percapita (i.e., those who reported eating the relevant commodities as well as those who did 

not) basis. In accordance with HED policy, per capita exposure and risk are reported for 

all tiers of analysis. However, for tiers 1 and 2, any significant differences in user vs. per 

capita exposure and risk are specifically identified and noted in the risk assessment.
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

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Page 6 of 18

V. Toxicological Information

The findings of the flumioxazin risk assessment team, relative to dietary exposure, are 

summarized in Table 2 (below). In accordance with the EPA Draft Guidelines for 

Carcinogen Risk Assessment (July, 1999), flumioxazin was classified as “not likely to be 

carcinogenic to humans.” 

Table 2. Summary of Toxicological Doses and Endpoints for Use in Human Health Dietary

Risk Assessment for Flumioxazin. 

Exposure/

Scenario

Point of 

Departure

Uncertainty/

FQPA Safety 

Factors

RfD, PAD, 

Level of 

Concern 

Study and Toxicological 

Effects

Acute Dietary 

(General 

Population, 

including Infants 

and Children)

No endpoint attributable to a single dose (exposure) was identified in the available 

studies, including the developmental toxicity studies in rats and rabbits. 

Acute Dietary

(Females 13-49 

years of age)

NOAEL = 3 

mg/kg/day

UFA= 10x

UFH= 10x

FQPA SF = 1X

Total UF = 100X

Acute RfD =

NOAEL UF = 

0.03 mg/kg/day

aPAD = 0.03 

mg/kg/day

Oral developmental and 

supplemental prenatal studies 

in the rat. 

LOAEL = 10 mg/kg/day 

based on cardiovascular 

effects (especially ventricular 

septal defects in fetuses).

Chronic Dietary 

(All Populations)

NOAEL = 2 

mg/kg/day

UFA= 10x

UFH= 10x

FQPA SF = 1X

Total UF = 100X

Chronic RfD 

FQPA SF = 

0.02 mg/kg/day

cPAD = 0.02 

mg/kg/day

2-year chronic/carcinogenicity 

study in the rat. 

LOAEL = 18 mg/kg/day 

based on increased chronic 

nephropathy in males, and 

decreased hematological 

parameters in females (Hgb, 

MCV, MCH, and MCHC). 

Cancer (oral, dermal, inhalation) Classification: “Not likely to be Carcinogenic to Humans” based on 

the lack of carcinogenicity in a 2-year rat study, an 18-month mouse 

study, and a battery of mutagenic studies. 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (intraspecies). UFH = potential variation in sensitivity

among members of the human population (interspecies). UFL = use of a LOAEL to extrapolate a NOAEL. UFS = use 

of a short-term study for long-term risk assessment. UFDB = to account for the absence of key data (i.e., lack of a 

critical study). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = 

reference dose.
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

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Page 7 of 18

VI. Results/Discussion 

As stated above, for acute or chronic dietary assessments, HED is concerned when 

dietary risk exceeds 100% of the PAD. The DEEM-FCID analyses estimate the dietary 

exposure of the US population and various population subgroups. The results reported in 

Table 3 (below) are for the general US population (total), all infants <1, children 1-2, 

children 3-5, children 6-12, youths 13-19, females 13-49, adults 20-49, and adults 50+ for 

chronic exposure and females 13-49 for acute exposure. 

Results of Acute Dietary Exposure Analysis

Flumioxazin acute dietary (food + water) exposure estimates using the DEEM-FCIDTM 

software are below HED’s level of concern for females 13-49. The acute dietary 

exposure for the females, 13-49 years old, utilized 68% of the aPAD at the 95th

percentile.

Results of Chronic Dietary Exposure Analysis

Flumioxazin chronic dietary (food + water) exposure estimates using the DEEM-FCIDTM 

software are below HED’s level of concern for the U.S. population and each of the 

population subgroups. Chronic dietary exposure utilized 20% of the cPAD for the U.S. 

population. The chronic dietary exposure for the highest reported exposed population 

subgroup, all infants (<1 year old), was 54% of the cPAD.

Table 3. Summary of Dietary Exposure and Risk for Flumioxazin. 

Population Subgroup1

DEEM Acute Dietary Analysis,

95th Percentile

DEEM Chronic Dietary Analysis

aPAD 

(mg/kg/day)

Exposure 

(mg/kg/day)

% 

aPAD

cPAD 

(mg/kg/day)

Exposure 

(mg/kg/day)

% 

cPAD

General U.S. Population

NA 2

0.02 0.003976 20

All Infants (< 1 year 

old)

0.02 0.010863 54

Children 1-2 years old 0.02 0.006844 34 

Children 3-5 years old 0.02 0.006516 33

Children 6-12 years old 0.02 0.004490 23

Youth 13-19 years old 0.02 0.003101 16

Adults 20-49 years old 0.02 0.003565 18

Adults 50+ years old 0.02 0.003627 18

Females 13-49 years old 0.03 0.020349 68 0.02 0.003536 18
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

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Page 8 of 18

1 Values for the population with the highest risk for each type of risk assessment are bolded. 

2 NA = Not Applicable; no acute dietary endpoint was identified for these population subgroups

VII. Characterization of Inputs/Outputs

The assumptions made in this assessment are conservative, and are very likely to result in 

exposure and risk values that considerably overestimate actual dietary exposure to 

flumioxazin. Although not needed at this time, the analyses could be further refined 

through the use of average residues based on field trial data, percent crop treated data 

and/or preparation/cooking factors. Since risk estimates are below HED’s level of 

concern, a more highly refined analysis is not needed at this time.

VIII.Conclusions

This highly conservative, unrefined analysis demonstrates that the requested uses for 

flumioxazin will not result in acute and chronic dietary risk estimates that exceed HED’s 

level of concern for any of the regulated populated subgroups, including those comprised 

of infants and children. 

IX. List of Attachments

Attachment 1: Acute Food plus Water Residue Input File

Attachment 2: Acute Results File

Attachment 3: Chronic Food plus Water Residue Input File

Attachment 4: Chronic Results File

Attachment 5: Chemical Structure of Flumioxazin and metabolites (482-HA and APF) 

.
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

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Page 9 of 18

Attachment 1: Acute Food plus Water Residue Input File

Filename: C:\Deemfcid\Flumioxazin_acute.R98 Chemical: Flumioxazin

RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .03 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 05-10-2012/14:34:11/8 Program ver. 2.03

Comment: Food + Drinking Water

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

01030150 1CD Arrowroot, flour 0.020000 1.000 1.000 

01030151 1CD Arrowroot, flour-babyfood 0.020000 1.000 1.000 

01030170 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 

01030820 1CD Cassava 0.020000 1.000 1.000 

01030821 1CD Cassava-babyfood 0.020000 1.000 1.000 

01031390 1CD Dasheen, corm 0.020000 1.000 1.000 

01031660 1CD Ginger 0.020000 1.000 1.000 

01031661 1CD Ginger-babyfood 0.020000 1.000 1.000 

01031670 1CD Ginger, dried 0.020000 1.000 1.000 

01032960 1C Potato, chips 0.020000 1.000 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.020000 6.500 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.020000 6.500 1.000 

01032980 1C Potato, flour 0.020000 1.000 1.000 

01032981 1C Potato, flour-babyfood 0.020000 1.000 1.000 

01032990 1C Potato, tuber, w/peel 0.020000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 

01033660 1CD Sweet potato 0.020000 1.000 1.000 

01033661 1CD Sweet potato-babyfood 0.020000 1.000 1.000 

01033710 1CD Tanier, corm 0.020000 1.000 1.000 

01033870 1CD Turmeric 0.020000 1.000 1.000 

01034060 1CD Yam, true 0.020000 1.000 1.000 

01034070 1CD Yam bean 0.020000 1.000 1.000 

03001640 3 Garlic 0.020000 1.000 1.000 

03001650 3 Garlic, dried 0.020000 9.000 1.000 

03001651 3 Garlic, dried-babyfood 0.020000 1.000 1.000 

03002370 3 Onion, dry bulb 0.020000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.020000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.020000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.020000 9.000 1.000 

04020760 4B Cardoon 0.020000 1.000 1.000 

04020850 4B Celery 0.020000 1.000 1.000 

04020851 4B Celery-babyfood 0.020000 1.000 1.000 

04020860 4B Celery, juice 0.020000 1.000 1.000 

04020870 4B Celtuce 0.020000 1.000 1.000 

04021520 4B Fennel, Florence 0.020000 1.000 1.000 

04023220 4B Rhubarb 0.020000 1.000 1.000 

04023670 4B Swiss chard 0.020000 1.000 1.000 

06003470 6 Soybean, seed 0.020000 1.000 1.000 

06003480 6 Soybean, flour 0.020000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.020000 1.000 1.000 

06003490 6 Soybean, soy milk 0.020000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.020000 1.000 1.000 

06003500 6 Soybean, oil 0.020000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.020000 1.000 1.000 

06030300 6C Bean, black, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030320 6C Bean, broad, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030340 6C Bean, cowpea, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030350 6C Bean, great northern, seed 0.070000 1.000 1.000 new us

 Full comment: new use
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

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06030360 6C Bean, kidney, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030380 6C Bean, lima, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030390 6C Bean, mung, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030400 6C Bean, navy, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030410 6C Bean, pink, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030420 6C Bean, pinto, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030980 6C Chickpea, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030981 6C Chickpea, seed-babyfood 0.070000 1.000 1.000 new us

 Full comment: new use

06030990 6C Chickpea, flour 0.070000 1.000 1.000 new us

 Full comment: new use

06031820 6C Guar, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06031821 6C Guar, seed-babyfood 0.070000 1.000 1.000 new us

 Full comment: new use

06032030 6C Lentil, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06032560 6C Pea, dry 0.070000 1.000 1.000 new us

 Full comment: new use

06032561 6C Pea, dry-babyfood 0.070000 1.000 1.000 new us

 Full comment: new use

06032580 6C Pea, pigeon, seed 0.070000 1.000 1.000 new us

 Full comment: new use

08001480 8 Eggplant 0.020000 1.000 1.000 

08002340 8 Okra 0.020000 1.000 1.000 

08002700 8 Pepper, bell 0.020000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.020000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.020000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.020000 1.000 1.000 

08002720 8 Pepper, nonbell 0.020000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.020000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.020000 1.000 1.000 

08003740 8 Tomatillo 0.020000 1.000 1.000 

08003750 8 Tomato 0.020000 1.000 1.000 

08003751 8 Tomato-babyfood 0.020000 1.000 1.000 

08003760 8 Tomato, paste 0.020000 1.000 1.000 

08003761 8 Tomato, paste-babyfood 0.020000 1.000 1.000 

08003770 8 Tomato, puree 0.020000 1.000 1.000 

08003771 8 Tomato, puree-babyfood 0.020000 1.000 1.000 

08003780 8 Tomato, dried 0.020000 1.000 1.000 

08003781 8 Tomato, dried-babyfood 0.020000 1.000 1.000 

08003790 8 Tomato, juice 0.020000 1.000 1.000 

09010750 9A Cantaloupe 0.030000 1.000 1.000 

09010800 9A Casaba 0.030000 1.000 1.000 

09011870 9A Honeydew melon 0.030000 1.000 1.000 

09013990 9A Watermelon 0.030000 1.000 1.000 

09014000 9A Watermelon, juice 0.030000 1.000 1.000 

09020210 9B Balsam pear 0.030000 1.000 1.000 

09020880 9B Chayote, fruit 0.030000 1.000 1.000 

09021020 9B Chinese waxgourd 0.030000 1.000 1.000 

09021350 9B Cucumber 0.030000 1.000 1.000 

09023080 9B Pumpkin 0.030000 1.000 1.000 

09023090 9B Pumpkin, seed 0.030000 1.000 1.000 

09023560 9B Squash, summer 0.030000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.030000 1.000 1.000 

09023570 9B Squash, winter 0.030000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.030000 1.000 1.000 

11000070 11 Apple, fruit with peel 0.020000 1.000 1.000 

11000080 11 Apple, peeled fruit 0.020000 1.000 1.000 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

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11000081 11 Apple, peeled fruit-babyfood 0.020000 1.000 1.000 

11000090 11 Apple, dried 0.020000 8.000 1.000 

11000091 11 Apple, dried-babyfood 0.020000 8.000 1.000 

11000100 11 Apple, juice 0.020000 1.300 1.000 

11000101 11 Apple, juice-babyfood 0.020000 1.300 1.000 

11000110 11 Apple, sauce 0.020000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 0.020000 1.000 1.000 

11001290 11 Crabapple 0.020000 1.000 1.000 

11002100 11 Loquat 0.020000 1.000 1.000 

11002660 11 Pear 0.020000 1.000 1.000 

11002661 11 Pear-babyfood 0.020000 1.000 1.000 

11002670 11 Pear, dried 0.020000 6.250 1.000 

11002680 11 Pear, juice 0.020000 1.000 1.000 

11002681 11 Pear, juice-babyfood 0.020000 1.000 1.000 

11003100 11 Quince 0.020000 1.000 1.000 

12000120 12 Apricot 0.020000 1.000 1.000 

12000121 12 Apricot-babyfood 0.020000 1.000 1.000 

12000130 12 Apricot, dried 0.020000 6.000 1.000 

12000140 12 Apricot, juice 0.020000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 0.020000 1.000 1.000 

12000900 12 Cherry 0.020000 1.000 1.000 

12000901 12 Cherry-babyfood 0.020000 1.000 1.000 

12000910 12 Cherry, juice 0.020000 1.500 1.000 

12000911 12 Cherry, juice-babyfood 0.020000 1.500 1.000 

12002300 12 Nectarine 0.020000 1.000 1.000 

12002600 12 Peach 0.020000 1.000 1.000 

12002601 12 Peach-babyfood 0.020000 1.000 1.000 

12002610 12 Peach, dried 0.020000 7.000 1.000 

12002611 12 Peach, dried-babyfood 0.020000 7.000 1.000 

12002620 12 Peach, juice 0.020000 1.000 1.000 

12002621 12 Peach, juice-babyfood 0.020000 1.000 1.000 

12002850 12 Plum 0.020000 1.000 1.000 

12002851 12 Plum-babyfood 0.020000 1.000 1.000 

12002860 12 Plum, prune, fresh 0.020000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 0.020000 1.000 1.000 

12002870 12 Plum, prune, dried 0.020000 5.000 1.000 

12002871 12 Plum, prune, dried-babyfood 0.020000 5.000 1.000 

12002880 12 Plum, prune, juice 0.020000 1.400 1.000 

12002881 12 Plum, prune, juice-babyfood 0.020000 1.400 1.000 

13020570 13B Blueberry 0.020000 1.000 1.000 

13020571 13B Blueberry-babyfood 0.020000 1.000 1.000 

13021360 13B Currant 0.020000 1.000 1.000 

13021370 13B Currant, dried 0.020000 1.000 1.000 

13021490 13B Elderberry 0.020000 1.000 1.000 

13021740 13B Gooseberry 0.020000 1.000 1.000 

13021910 13B Huckleberry 0.020000 1.000 1.000 

14000030 14 Almond 0.020000 1.000 1.000 

14000031 14 Almond-babyfood 0.020000 1.000 1.000 

14000040 14 Almond, oil 0.020000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.020000 1.000 1.000 

14000590 14 Brazil nut 0.020000 1.000 1.000 

14000680 14 Butternut 0.020000 1.000 1.000 

14000810 14 Cashew 0.020000 1.000 1.000 

14000920 14 Chestnut 0.020000 1.000 1.000 

14001550 14 Filbert 0.020000 1.000 1.000 

14001560 14 Filbert, oil 0.020000 1.000 1.000 

14001850 14 Hickory nut 0.020000 1.000 1.000 

14002130 14 Macadamia nut 0.020000 1.000 1.000 

14002690 14 Pecan 0.020000 1.000 1.000 

14002820 14 Pistachio 0.020000 1.000 1.000 

14003910 14 Walnut 0.020000 1.000 1.000 

15001200 15 Corn, field, flour 0.020000 1.000 1.000 

15001201 15 Corn, field, flour-babyfood 0.020000 1.000 1.000 

15001210 15 Corn, field, meal 0.020000 1.000 1.000 

15001211 15 Corn, field, meal-babyfood 0.020000 1.000 1.000 

15001220 15 Corn, field, bran 0.020000 1.000 1.000 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 12 of 18

15001230 15 Corn, field, starch 0.020000 1.000 1.000 

15001231 15 Corn, field, starch-babyfood 0.020000 1.000 1.000 

15001240 15 Corn, field, syrup 0.020000 1.000 1.000 

15001241 15 Corn, field, syrup-babyfood 0.020000 1.000 1.000 

15001250 15 Corn, field, oil 0.020000 1.000 1.000 

15001251 15 Corn, field, oil-babyfood 0.020000 1.000 1.000 

15004010 15 Wheat, grain 0.400000 1.000 1.000 new us

 Full comment: new use 

15004011 15 Wheat, grain-babyfood 0.400000 1.000 1.000 new us

 Full comment: new use 

15004020 15 Wheat, flour 0.400000 1.000 1.000 new us

 Full comment: new use 

15004021 15 Wheat, flour-babyfood 0.400000 1.000 1.000 new us

 Full comment: new use 

15004030 15 Wheat, germ 0.400000 1.000 1.000 new us

 Full comment: new use 

15004040 15 Wheat, bran 0.400000 1.000 1.000 new us

 Full comment: new use 

20001630 20 Flaxseed, oil 0.400000 1.000 1.000 new us

 Full comment: new use

20003190 20 Rapeseed, oil 0.400000 1.000 1.000 new us

 Full comment: new use

20003191 20 Rapeseed, oil-babyfood 0.400000 1.000 1.000 new us

 Full comment: new use

20003300 20 Safflower, oil 0.500000 1.000 1.000 new us

 Full comment: new use

20003301 20 Safflower, oil-babyfood 0.500000 1.000 1.000 new us

 Full comment: new use

20003640 20 Sunflower, seed 0.500000 1.000 1.000 new us

 Full comment: new use

20003650 20 Sunflower, oil 0.500000 1.000 1.000 new us

 Full comment: new use

20003651 20 Sunflower, oil-babyfood 0.500000 1.000 1.000 new us

 Full comment: new use

80001570 F Fish-freshwater finfish 1.500000 1.000 1.000 

80001580 F Fish-freshwater finfish, farm ra 1.500000 1.000 1.000 

86010000 O Water, direct, all sources 0.400000 1.000 1.000 aquati

 Full comment: aquatic herbicide 

86020000 O Water, indirect, all sources 0.400000 1.000 1.000 aquati

 Full comment: aquatic herbicide 

95000190 O Asparagus 0.020000 1.000 1.000 

95001280 O Cottonseed, oil 0.020000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.020000 1.000 1.000 

95001750 O Grape 0.020000 1.000 1.000 

95001760 O Grape, juice 0.020000 1.200 1.000 

95001761 O Grape, juice-babyfood 0.020000 1.200 1.000 

95001770 O Grape, leaves 0.020000 1.000 1.000 

95001780 O Grape, raisin 0.020000 4.300 1.000 

95001790 O Grape, wine and sherry 0.020000 1.000 1.000 

95001880 O Hop 0.050000 1.000 1.000 

95002630 O Peanut 0.020000 1.000 1.000 

95002640 O Peanut, butter 0.020000 1.890 1.000 

95002650 O Peanut, oil 0.020000 1.000 1.000 

95002750 O Peppermint 0.040000 1.000 1.000 

95002760 O Peppermint, oil 0.040000 1.000 1.000 

95003520 O Spearmint 0.040000 1.000 1.000 

95003530 O Spearmint, oil 0.040000 1.000 1.000 

95003590 O Strawberry 0.070000 1.000 1.000 

95003591 O Strawberry-babyfood 0.070000 1.000 1.000 

95003600 O Strawberry, juice 0.070000 1.000 1.000 

95003601 O Strawberry, juice-babyfood 0.070000 1.000 1.000 

95003620 O Sugarcane, sugar 0.200000 1.000 1.000 

95003621 O Sugarcane, sugar-babyfood 0.200000 1.000 1.000 

95003630 O Sugarcane, molasses 0.200000 1.000 1.000 

95003631 O Sugarcane, molasses-babyfood 0.200000 1.000 1.000 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 13 of 18

Attachment 2: Acute Results File

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for FLUMIOXAZIN (1994-98 data)

Residue file: Flumioxazin_acute.R98 Adjustment factor #2 NOT used.

Analysis Date: 05-10-2012/14:34:36 Residue file dated: 05-10-2012/14:34:11/8

Daily totals for food and foodform consumption used.

Run Comment: "Food + Drinking Water"

===============================================================================

Summary calculations (per capita):

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Females 13-49 yrs:

 0.020349 67.83 0.032318 107.73 0.056892 189.64

Attachment 3: Chronic Food plus Water Residue Input File

Filename: C:\Deemfcid\Flumioxazin_chronic.R98 Chemical: Flumioxazin

RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .03 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 05-10-2012/14:31:00/8 Program ver. 2.03

Comment: Food + Drinking Water

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

01030150 1CD Arrowroot, flour 0.020000 1.000 1.000 

01030151 1CD Arrowroot, flour-babyfood 0.020000 1.000 1.000 

01030170 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 

01030820 1CD Cassava 0.020000 1.000 1.000 

01030821 1CD Cassava-babyfood 0.020000 1.000 1.000 

01031390 1CD Dasheen, corm 0.020000 1.000 1.000 

01031660 1CD Ginger 0.020000 1.000 1.000 

01031661 1CD Ginger-babyfood 0.020000 1.000 1.000 

01031670 1CD Ginger, dried 0.020000 1.000 1.000 

01032960 1C Potato, chips 0.020000 1.000 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.020000 6.500 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.020000 6.500 1.000 

01032980 1C Potato, flour 0.020000 1.000 1.000 

01032981 1C Potato, flour-babyfood 0.020000 1.000 1.000 

01032990 1C Potato, tuber, w/peel 0.020000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 

01033660 1CD Sweet potato 0.020000 1.000 1.000 

01033661 1CD Sweet potato-babyfood 0.020000 1.000 1.000 

01033710 1CD Tanier, corm 0.020000 1.000 1.000 

01033870 1CD Turmeric 0.020000 1.000 1.000 

01034060 1CD Yam, true 0.020000 1.000 1.000 

01034070 1CD Yam bean 0.020000 1.000 1.000 

03001640 3 Garlic 0.020000 1.000 1.000 

03001650 3 Garlic, dried 0.020000 9.000 1.000 

03001651 3 Garlic, dried-babyfood 0.020000 1.000 1.000 

03002370 3 Onion, dry bulb 0.020000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.020000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.020000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.020000 9.000 1.000 

04020760 4B Cardoon 0.020000 1.000 1.000 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 14 of 18

04020850 4B Celery 0.020000 1.000 1.000 

04020851 4B Celery-babyfood 0.020000 1.000 1.000 

04020860 4B Celery, juice 0.020000 1.000 1.000 

04020870 4B Celtuce 0.020000 1.000 1.000 

04021520 4B Fennel, Florence 0.020000 1.000 1.000 

04023220 4B Rhubarb 0.020000 1.000 1.000 

04023670 4B Swiss chard 0.020000 1.000 1.000 

06003470 6 Soybean, seed 0.020000 1.000 1.000 

06003480 6 Soybean, flour 0.020000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.020000 1.000 1.000 

06003490 6 Soybean, soy milk 0.020000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.020000 1.000 1.000 

06003500 6 Soybean, oil 0.020000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.020000 1.000 1.000 

06030300 6C Bean, black, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030320 6C Bean, broad, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030340 6C Bean, cowpea, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030350 6C Bean, great northern, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030360 6C Bean, kidney, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030380 6C Bean, lima, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030390 6C Bean, mung, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030400 6C Bean, navy, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030410 6C Bean, pink, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030420 6C Bean, pinto, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030980 6C Chickpea, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06030981 6C Chickpea, seed-babyfood 0.070000 1.000 1.000 new us

 Full comment: new use

06030990 6C Chickpea, flour 0.070000 1.000 1.000 new us

 Full comment: new use

06031820 6C Guar, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06031821 6C Guar, seed-babyfood 0.070000 1.000 1.000 new us

 Full comment: new use

06032030 6C Lentil, seed 0.070000 1.000 1.000 new us

 Full comment: new use

06032560 6C Pea, dry 0.070000 1.000 1.000 new us

 Full comment: new use

06032561 6C Pea, dry-babyfood 0.070000 1.000 1.000 new us

 Full comment: new use

06032580 6C Pea, pigeon, seed 0.070000 1.000 1.000 new us

 Full comment: new use

08001480 8 Eggplant 0.020000 1.000 1.000 

08002340 8 Okra 0.020000 1.000 1.000 

08002700 8 Pepper, bell 0.020000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.020000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.020000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.020000 1.000 1.000 

08002720 8 Pepper, nonbell 0.020000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.020000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.020000 1.000 1.000 

08003740 8 Tomatillo 0.020000 1.000 1.000 

08003750 8 Tomato 0.020000 1.000 1.000 

08003751 8 Tomato-babyfood 0.020000 1.000 1.000 

08003760 8 Tomato, paste 0.020000 1.000 1.000 

08003761 8 Tomato, paste-babyfood 0.020000 1.000 1.000 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 15 of 18

08003770 8 Tomato, puree 0.020000 1.000 1.000 

08003771 8 Tomato, puree-babyfood 0.020000 1.000 1.000 

08003780 8 Tomato, dried 0.020000 1.000 1.000 

08003781 8 Tomato, dried-babyfood 0.020000 1.000 1.000 

08003790 8 Tomato, juice 0.020000 1.000 1.000 

09010750 9A Cantaloupe 0.030000 1.000 1.000 

09010800 9A Casaba 0.030000 1.000 1.000 

09011870 9A Honeydew melon 0.030000 1.000 1.000 

09013990 9A Watermelon 0.030000 1.000 1.000 

09014000 9A Watermelon, juice 0.030000 1.000 1.000 

09020210 9B Balsam pear 0.030000 1.000 1.000 

09020880 9B Chayote, fruit 0.030000 1.000 1.000 

09021020 9B Chinese waxgourd 0.030000 1.000 1.000 

09021350 9B Cucumber 0.030000 1.000 1.000 

09023080 9B Pumpkin 0.030000 1.000 1.000 

09023090 9B Pumpkin, seed 0.030000 1.000 1.000 

09023560 9B Squash, summer 0.030000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.030000 1.000 1.000 

09023570 9B Squash, winter 0.030000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.030000 1.000 1.000 

11000070 11 Apple, fruit with peel 0.020000 1.000 1.000 

11000080 11 Apple, peeled fruit 0.020000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 0.020000 1.000 1.000 

11000090 11 Apple, dried 0.020000 8.000 1.000 

11000091 11 Apple, dried-babyfood 0.020000 8.000 1.000 

11000100 11 Apple, juice 0.020000 1.300 1.000 

11000101 11 Apple, juice-babyfood 0.020000 1.300 1.000 

11000110 11 Apple, sauce 0.020000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 0.020000 1.000 1.000 

11001290 11 Crabapple 0.020000 1.000 1.000 

11002100 11 Loquat 0.020000 1.000 1.000 

11002660 11 Pear 0.020000 1.000 1.000 

11002661 11 Pear-babyfood 0.020000 1.000 1.000 

11002670 11 Pear, dried 0.020000 6.250 1.000 

11002680 11 Pear, juice 0.020000 1.000 1.000 

11002681 11 Pear, juice-babyfood 0.020000 1.000 1.000 

11003100 11 Quince 0.020000 1.000 1.000 

12000120 12 Apricot 0.020000 1.000 1.000 

12000121 12 Apricot-babyfood 0.020000 1.000 1.000 

12000130 12 Apricot, dried 0.020000 6.000 1.000 

12000140 12 Apricot, juice 0.020000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 0.020000 1.000 1.000 

12000900 12 Cherry 0.020000 1.000 1.000 

12000901 12 Cherry-babyfood 0.020000 1.000 1.000 

12000910 12 Cherry, juice 0.020000 1.500 1.000 

12000911 12 Cherry, juice-babyfood 0.020000 1.500 1.000 

12002300 12 Nectarine 0.020000 1.000 1.000 

12002600 12 Peach 0.020000 1.000 1.000 

12002601 12 Peach-babyfood 0.020000 1.000 1.000 

12002610 12 Peach, dried 0.020000 7.000 1.000 

12002611 12 Peach, dried-babyfood 0.020000 7.000 1.000 

12002620 12 Peach, juice 0.020000 1.000 1.000 

12002621 12 Peach, juice-babyfood 0.020000 1.000 1.000 

12002850 12 Plum 0.020000 1.000 1.000 

12002851 12 Plum-babyfood 0.020000 1.000 1.000 

12002860 12 Plum, prune, fresh 0.020000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 0.020000 1.000 1.000 

12002870 12 Plum, prune, dried 0.020000 5.000 1.000 

12002871 12 Plum, prune, dried-babyfood 0.020000 5.000 1.000 

12002880 12 Plum, prune, juice 0.020000 1.400 1.000 

12002881 12 Plum, prune, juice-babyfood 0.020000 1.400 1.000 

13020570 13B Blueberry 0.020000 1.000 1.000 

13020571 13B Blueberry-babyfood 0.020000 1.000 1.000 

13021360 13B Currant 0.020000 1.000 1.000 

13021370 13B Currant, dried 0.020000 1.000 1.000 

13021490 13B Elderberry 0.020000 1.000 1.000 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 16 of 18

13021740 13B Gooseberry 0.020000 1.000 1.000 

13021910 13B Huckleberry 0.020000 1.000 1.000 

14000030 14 Almond 0.020000 1.000 1.000 

14000031 14 Almond-babyfood 0.020000 1.000 1.000 

14000040 14 Almond, oil 0.020000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.020000 1.000 1.000 

14000590 14 Brazil nut 0.020000 1.000 1.000 

14000680 14 Butternut 0.020000 1.000 1.000 

14000810 14 Cashew 0.020000 1.000 1.000 

14000920 14 Chestnut 0.020000 1.000 1.000 

14001550 14 Filbert 0.020000 1.000 1.000 

14001560 14 Filbert, oil 0.020000 1.000 1.000 

14001850 14 Hickory nut 0.020000 1.000 1.000 

14002130 14 Macadamia nut 0.020000 1.000 1.000 

14002690 14 Pecan 0.020000 1.000 1.000 

14002820 14 Pistachio 0.020000 1.000 1.000 

14003910 14 Walnut 0.020000 1.000 1.000 

15001200 15 Corn, field, flour 0.020000 1.000 1.000 

15001201 15 Corn, field, flour-babyfood 0.020000 1.000 1.000 

15001210 15 Corn, field, meal 0.020000 1.000 1.000 

15001211 15 Corn, field, meal-babyfood 0.020000 1.000 1.000 

15001220 15 Corn, field, bran 0.020000 1.000 1.000 

15001230 15 Corn, field, starch 0.020000 1.000 1.000 

15001231 15 Corn, field, starch-babyfood 0.020000 1.000 1.000 

15001240 15 Corn, field, syrup 0.020000 1.000 1.000 

15001241 15 Corn, field, syrup-babyfood 0.020000 1.000 1.000 

15001250 15 Corn, field, oil 0.020000 1.000 1.000 

15001251 15 Corn, field, oil-babyfood 0.020000 1.000 1.000 

15004010 15 Wheat, grain 0.400000 1.000 1.000 new us

 Full comment: new use 

15004011 15 Wheat, grain-babyfood 0.400000 1.000 1.000 new us

 Full comment: new use 

15004020 15 Wheat, flour 0.400000 1.000 1.000 new us

 Full comment: new use 

15004021 15 Wheat, flour-babyfood 0.400000 1.000 1.000 new us

 Full comment: new use 

15004030 15 Wheat, germ 0.400000 1.000 1.000 new us

 Full comment: new use 

15004040 15 Wheat, bran 0.400000 1.000 1.000 new us

 Full comment: new use 

20001630 20 Flaxseed, oil 0.400000 1.000 1.000 new us

 Full comment: new use

20003190 20 Rapeseed, oil 0.400000 1.000 1.000 new us

 Full comment: new use

20003191 20 Rapeseed, oil-babyfood 0.400000 1.000 1.000 new us

 Full comment: new use

20003300 20 Safflower, oil 0.500000 1.000 1.000 new us

 Full comment: new use

20003301 20 Safflower, oil-babyfood 0.500000 1.000 1.000 new us

 Full comment: new use

20003640 20 Sunflower, seed 0.500000 1.000 1.000 new us

 Full comment: new use

20003650 20 Sunflower, oil 0.500000 1.000 1.000 new us

 Full comment: new use

20003651 20 Sunflower, oil-babyfood 0.500000 1.000 1.000 new us

 Full comment: new use

80001570 F Fish-freshwater finfish 1.500000 1.000 1.000 

80001580 F Fish-freshwater finfish, farm ra 1.500000 1.000 1.000 

86010000 O Water, direct, all sources 0.142000 1.000 1.000 aquati

 Full comment: aquatic herbicide 

86020000 O Water, indirect, all sources 0.142000 1.000 1.000 aquati

 Full comment: aquatic herbicide 

95000190 O Asparagus 0.020000 1.000 1.000 

95001280 O Cottonseed, oil 0.020000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.020000 1.000 1.000 

95001750 O Grape 0.020000 1.000 1.000 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 17 of 18

95001760 O Grape, juice 0.020000 1.200 1.000 

95001761 O Grape, juice-babyfood 0.020000 1.200 1.000 

95001770 O Grape, leaves 0.020000 1.000 1.000 

95001780 O Grape, raisin 0.020000 4.300 1.000 

95001790 O Grape, wine and sherry 0.020000 1.000 1.000 

95001880 O Hop 0.050000 1.000 1.000 

95002630 O Peanut 0.020000 1.000 1.000 

95002640 O Peanut, butter 0.020000 1.890 1.000 

95002650 O Peanut, oil 0.020000 1.000 1.000 

95002750 O Peppermint 0.040000 1.000 1.000 

95002760 O Peppermint, oil 0.040000 1.000 1.000 

95003520 O Spearmint 0.040000 1.000 1.000 

95003530 O Spearmint, oil 0.040000 1.000 1.000 

95003590 O Strawberry 0.070000 1.000 1.000 

95003591 O Strawberry-babyfood 0.070000 1.000 1.000 

95003600 O Strawberry, juice 0.070000 1.000 1.000 

95003601 O Strawberry, juice-babyfood 0.070000 1.000 1.000 

95003620 O Sugarcane, sugar 0.200000 1.000 1.000 

95003621 O Sugarcane, sugar-babyfood 0.200000 1.000 1.000 

95003630 O Sugarcane, molasses 0.200000 1.000 1.000 

95003631 O Sugarcane, molasses-babyfood 0.200000 1.000 1.000 

Attachment 4: Chronic Results File

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for FLUMIOXAZIN (1994-98 data)

Residue file name: C:\Deemfcid\Flumioxazin_chronic.R98

 Adjustment factor #2 NOT used.

Analysis Date 05-10-2012/14:31:19 Residue file dated: 05-10-2012/14:31:00/8

Reference dose (RfD, Chronic) = .02 mg/kg bw/day

COMMENT 1: Food + Drinking Water

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.003976 19.9%

U.S. Population (spring season) 0.003966 19.8%

U.S. Population (summer season) 0.004185 20.9%

U.S. Population (autumn season) 0.003879 19.4%

U.S. Population (winter season) 0.003872 19.4%

Northeast region 0.003734 18.7%

Midwest region 0.004055 20.3%

Southern region 0.003777 18.9%

Western region 0.004427 22.1%

Hispanics 0.004329 21.6%

Non-hispanic whites 0.003910 19.6%

Non-hispanic blacks 0.003806 19.0%

Non-hisp/non-white/non-black 0.004721 23.6%

All infants (< 1 year) 0.010863 54.3%

Nursing infants 0.004109 20.5%
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 18 of 18

Non-nursing infants 0.013427 67.1%

Children 1-6 yrs 0.006502 32.5%

Children 7-12 yrs 0.004260 21.3%

Females 13-19 (not preg or nursing) 0.002949 14.7%

Females 20+ (not preg or nursing) 0.003687 18.4%

Females 13-50 yrs 0.003682 18.4%

Females 13+ (preg/not nursing) 0.003716 18.6%

Females 13+ (nursing) 0.005116 25.6%

Males 13-19 yrs 0.003228 16.1%

Males 20+ yrs 0.003462 17.3%

Seniors 55+ 0.003627 18.1%

Children 1-2 yrs 0.006844 34.2%

Children 3-5 yrs 0.006516 32.6%

Children 6-12 yrs 0.004490 22.5%

Youth 13-19 yrs 0.003101 15.5%

Adults 20-49 yrs 0.003565 17.8%

Adults 50+ yrs 0.003627 18.1%

Females 13-49 yrs 0.003536 17.7%

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Attachment 5: Chemical Structure of Flumioxazin and metabolites (482-HA and 

APF).

Chemical Name Structure

Flumioxazin

2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-

propynyl)-2H-1,4-benzoxazin-6-yl]-

4,5,6,7-tetrahydro-1H-isoindole1,3(2H)-dione

O N

N O

O

O

F

C CH

482-HA

N-[7-fluoro-3-oxo-4-(2-propynyl)-

2H-1,4-benzoxazin-6-yl]-3,4,5,6-

tetrahydrophthalamic acid

HO

O

O

N

H

O

N

O

F

C CH

APF

6-amino-7-fluoro-4-(2-propenyl)-

2H-1,4-benzoxazin-3(4H)-one O

N O

F NH2 C CH