Form of Warrant



 THIS WARRANT AND THE SECURITIES ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED, OR ANY APPLICABLE STATE LAWS, AND NO INTEREST THEREIN MAY BE SOLD, DISTRIBUTED, ASSIGNED, OFFERED, PLEDGED OR OTHERWISE TRANSFERRED UNLESS THERE IS AN EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT AND APPLICABLE STATE SECURITIES LAWS
COVERING ANY SUCH TRANSACTION, OR SUCH TRANSACTION IS EXEMPT FROM THE REGISTRATION REQUIREMENTS OF SUCH ACT AND LAWS, SUCH COMPLIANCE, AT THE OPTION OF THE CORPORATION, TO BE EVIDENCED BY AN OPINION OF THE WARRANT HOLDER’S COUNSEL, IN FORM
ACCEPTABLE TO THE CORPORATION, THAT NO VIOLATION OF SUCH REGISTRATION PROVISIONS WOULD RESULT FROM ANY PROPOSED TRANSFER OR ASSIGNMENT. 
  
 COMMON STOCK PURCHASE WARRANT 
  
 ARBIOS TECHNOLOGIES, INC. 
  
 THIS CERTIFIES that for good and valuable consideration received,
                     or a registered assignee (the “Holder”) is entitled, upon the terms and subject to the conditions
hereinafter set forth, to acquire from Arbios Technologies, Inc., a Delaware corporation (the “Corporation”), up to
                     fully paid and nonassessable shares of common stock, par value $0.00001, of the Corporation (“Warrant
Stock”) at a purchase price per share (the “Exercise Price”) of $2.50 (the “Warrant”). 
  
 1. Term of Warrant. 
  
 Subject to the terms and conditions set forth herein, this Warrant shall be exercisable, in whole or in part, at any time on or after the date hereof and
at or prior to 11:59 p.m., Pacific Standard Time, on October 29, 2006 (the “Expiration Time”). Notwithstanding the foregoing, the Corporation shall have the right (the “Call Right”), except as may be limited by law,
other agreements or herein, to repurchase this Warrant if the average closing price for the Corporation’s common stock, as quoted on the principal trading system on which the common stock is listed (such as the OTC Bulletin Board, The Nasdaq
Stock Market, any stock exchange, or other established over-the-counter quotation service), is equal to or greater than $4.00 per share, as adjusted pursuant to Section 11 hereof, during the period of the twenty (20) consecutive trading days prior
to the date on which the Corporation elects to exercise the Call Right. The price at which the Corporation is entitled to exercise the Call Right (the “Repurchase Price”) shall be equal to the multiple of (i) $0.01 times (ii) the
number of Warrant Stock that this Warrant is then entitled to purchase. In the event that the 







 Corporation exercises its Call Right, the Corporation shall send the Holder written notice of the exercise of the Call
Right 20 calendar days before the repurchase becomes effective. The Holder shall have the right to exercise this Warrant until the close of business on the twentieth (20th) day after the mailing of the Call Right notice. If this Warrant is not exercised during the foregoing 20-day period, this Warrant shall expire and cease to
be exercisable on the twenty-first (21st) day after the date of mailing of the notice. Within three business days
after the expiration of this Warrant as a result of the exercise of the Call Right, the Corporation shall mail to the Holder a check in the amount of the Repurchase Price. 
  
 2. Exercise of Warrant. 
  
 The purchase rights represented by this Warrant are exercisable by the registered Holder hereof, in whole or in part, at any time and from time to time at
or prior to the Expiration Time by the surrender of this Warrant and the Notice of Exercise form attached hereto duly executed to the office of the Corporation at Cedars-Sinai Medical Center Research Building, Suite D-4018, 110 George Burns Road,
Los Angeles, California 90048 (or such other office or agency of the Corporation as it may designate by notice in writing to the registered Holder hereof at the address of such Holder appearing on the books of the Corporation), and upon payment of
the Exercise Price for the shares thereby purchased (by cash or by check or bank draft payable to the order of the Corporation or by cancellation of indebtedness of the Corporation to the Holder hereof, if any, at the time of exercise in an amount
equal to the purchase price of the shares thereby purchased); whereupon the Holder of this Warrant shall be entitled to receive from the Corporation a stock certificate in proper form representing the number of shares of Warrant Stock so purchased.

  
 3. Issuance of Shares; No Fractional Shares of Scrip.

  
 Certificates for shares purchased hereunder shall be
delivered to the Holder hereof by the Corporation’s transfer agent at the Corporation’s expense within a reasonable time after the date on which this Warrant shall have been exercised in accordance with the terms hereof. Each certificate
so delivered shall be in such denominations as may be requested by the Holder hereof and shall be registered in the name of such Holder or, subject to applicable laws, such other name as shall be requested by the Holder. If, upon exercise of this
Warrant, fewer than all of the shares of Warrant Stock evidenced by this Warrant are purchased prior to the Expiration Time, one or more new warrants substantially in the form of, and on the terms in, this Warrant will be issued for the remaining
number of shares of Warrant Stock not purchased upon exercise of this Warrant. The Corporation hereby represents and warrants that all shares of Warrant Stock which may be issued upon the exercise of this Warrant will, upon such exercise, be duly
and validly authorized and issued, fully paid and nonassessable and free from all taxes, liens and charges in respect of the issuance thereof (other than liens or charges created by or imposed upon the Holder of the Warrant Stock). The Corporation
agrees that the shares so issued shall be and will be deemed to be issued to such Holder as the record owner of such shares as of the close of business on the date on which this Warrant shall have been surrendered for exercise in accordance with the
terms hereof. No fractional shares or scrip representing fractional shares shall be issued upon the exercise of this 
  

 2 








 Warrant. With respect to any fraction of a share called for upon the exercise of this Warrant, an amount equal to such
fraction multiplied by the then current price at which each share may be purchased hereunder shall be paid in cash to the Holder of this Warrant. 
  
 4. Registration Rights. 
  
 Pursuant to the terms of the Subscription Agreement and Exhibit A thereto signed in conjunction with this Warrant, certain registration rights apply to
the Warrant Stock if (i) the last reported sales price of the common stock of the Corporation, as published by the principal trading market on which such common stock is then quoted, has exceeded two dollars and fifty cents ($2.50) for twenty (20)
consecutive trading days or (ii) if the Corporation is eligible to file a registration statement on Form S-3 with the Securities and Exchange Commission. See the Subscription Agreement and Exhibit A thereto for a full description of the registration
rights applicable to the Warrant Stock and the limitations on such rights. 
  
 5. Charges, Taxes and Expenses. 
  
 Issuance of certificates for shares of Warrant Stock upon the exercise of this Warrant shall be made without charge to the Holder hereof for any issue or transfer tax or other incidental expense in respect of the issuance of such
certificate, all of which taxes and expenses shall be paid by the Corporation, and such certificates shall be issued in the name of the Holder of this Warrant or in such name or names as may be directed by the Holder of this Warrant; provided,
however, that in the event certificates for shares of Warrant Stock are to be issued in a name other than the name of the Holder of this Warrant, this Warrant when surrendered for exercise shall be accompanied by an Assignment Form to be provided by
the Corporation duly executed by the Holder hereof. 
  
 6. No
Rights as Stockholders. 
  
 This Warrant does not entitle the
Holder hereof to any voting rights or other rights as a stockholder of the Corporation prior to the exercise hereof. 
  
 7. Exchange and Registry of Warrant. 
  
 This Warrant is exchangeable, upon the surrender hereof by the registered Holder at the above mentioned office or agency of the Corporation, for a new
Warrant of like tenor and dated as of such exchange. The Corporation shall maintain at the above-mentioned office or agency a registry showing the name and address of the registered Holder of this Warrant. This Warrant may be surrendered for
exchange, transfer or exercise, in accordance with its terms, at such office or agency of the Corporation, and the Corporation shall be entitled to rely in all respects, prior to written notice to the contrary, upon such registry. 
  

 3 








 8. Loss, Theft, Destruction or Mutilation of Warrant. 
  
 Upon receipt by the Corporation of evidence reasonably satisfactory to it of
the loss, theft, destruction or mutilation of this Warrant and in case of loss, theft or destruction of indemnity or security reasonably satisfactory to it, and upon reimbursement to the Corporation of all reasonable expenses incidental thereto, and
upon surrender and cancellation of this Warrant, if mutilated, the Corporation will make and deliver a new Warrant of like tenor and dated as of such cancellation, in lieu of this Warrant. 
  
 9. Saturdays, Sundays and Holidays. 
  
 If the last or appointed day for the taking of any action or the expiration
of any right required or granted herein shall be a Saturday or a Sunday or that is a legal holiday, then such action may be taken or such right may be exercised on the next succeeding day not a Saturday, Sunday or legal holiday. 
  
 10. Merger, Sale of Assets, Etc. 
  
 If at any time the Corporation proposes to merge or consolidate with or into
any other corporation, effect any reorganization, or sell or convey all or substantially all of its assets to any other entity, then, as a condition of such reorganization, consolidation, merger, sale or conveyance, the Corporation or its successor,
as the case may be, shall enter into a supplemental agreement to make lawful and adequate provision whereby the Holder shall have the right to receive, upon exercise of the Warrant, the kind and amount of equity securities which would have been
received upon such reorganization, consolidation, merger, sale or conveyance by a Holder of a number of shares of common stock equal to the number of shares issuable upon exercise of the Warrant immediately prior to such reorganization,
consolidation, merger, sale or conveyance. If the property to be received upon such reorganization, consolidation, merger, sale or conveyance is not equity securities, the Corporation shall give the Holder of this Warrant ten (10) business days
prior written notice of the proposed effective date of such transaction, and if this Warrant has not been exercised by or on the effective date of such transaction, it shall terminate. 
  
 11. Subdivision, Combination, Reclassification, Conversion, Etc. 
  
 If the Corporation at any time shall by subdivision, combination,
reclassification of securities or otherwise, change the Warrant Stock into the same or a different number of securities of any class or classes, this Warrant shall thereafter entitle the Holder to acquire such number and kind of securities as would
have been issuable in respect of the Warrant Stock (or other securities which were subject to the purchase rights under this Warrant immediately prior to such subdivision, combination, reclassification or other change) as the result of such change
if this Warrant had been exercised in full for cash immediately prior to such change. The Exercise Price hereunder shall be adjusted if and to the extent necessary to reflect such change. If the Warrant Stock or other securities issuable upon
exercise hereof are subdivided or combined into a greater or smaller number of shares of such security, the number of shares issuable hereunder shall be proportionately increased or decreased, as the 
  

 4 








 case may be, and the Exercise Price shall be proportionately reduced or increased, as the case may be, in both cases
according to the ratio which the total number of shares of such security to be outstanding immediately after such event bears to the total number of shares of such security outstanding immediately prior to such event. The Corporation shall give the
Holder prompt written notice of any change in the type of securities issuable hereunder, any adjustment of the Exercise Price for the securities issuable hereunder, and any increase or decrease in the number of shares issuable hereunder. 

 
 12. Transferability; Compliance with Securities Laws. 

 
 (a) This Warrant may not be transferred or assigned in whole or in part
without compliance with all applicable federal and state securities laws by the transferor and transferee (including the delivery of investment representation letters and legal opinions reasonably satisfactory to the Corporation, if requested by the
Corporation). Subject to such restrictions, prior to the Expiration Time, this Warrant and all rights hereunder are transferable by the Holder hereof, in whole or in part, at the office or agency of the Corporation referred to in Section 2 hereof.
Any such transfer shall be made in person or by the Holder’s duly authorized attorney, upon surrender of this Warrant together with the Assignment Form attached hereto properly endorsed. 
  
 (b) The Holder of this Warrant, by acceptance hereof, acknowledges that this
Warrant and the Warrant Stock issuable upon exercise hereof are being acquired solely for the Holder’s own account and not as a nominee for any other party, and for investment, and that the Holder will not offer, sell or otherwise dispose of
this Warrant or any shares of Warrant Stock to be issued upon exercise hereof except under circumstances that will not result in a violation of the Securities Act of 1933, as amended, or any state securities laws. Upon exercise of this Warrant, the
Holder shall, if requested by the Corporation, confirm in writing, in a form satisfactory to the Corporation, that the shares of Warrant Stock so purchased are being acquired solely for Holder’s own account and not as a nominee for any other
party, for investment, and not with a view toward distribution or resale. 
  
 (c) The Warrant Stock has not been and will not be registered under the Securities Act of 1933, as amended, and this Warrant may not be exercised except by (i) the original purchaser of this Warrant from the
Corporation or (ii) an “accredited investor” as defined in Rule 501(a) under the Securities Act of 1933, as amended. Each certificate representing the Warrant Stock or other securities issued in respect of the Warrant Stock upon any stock
split, stock dividend, recapitalization, merger, consolidation or similar event, shall be stamped or otherwise imprinted with a legend substantially in the following form (in addition to any legend required under applicable securities laws):

  
 THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE BEEN ACQUIRED FOR INVESTMENT
AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF, AND HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. SUCH SHARES MAY NOT BE SOLD OR TRANSFERRED IN THE ABSENCE OF SUCH REGISTRATION OR 

 

 5 








 UNLESS THE SALE OR TRANSFER IS EXEMPT FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS OF SAID ACT. 

 
 13. Representations and Warranties. 
  
 The Corporation hereby represents and warrants to the Holder hereof that:

  
 (a) during the period that this Warrant is outstanding, the
Corporation will reserve from its authorized and unissued common stock a sufficient number of shares to provide for the issuance of Warrant Stock upon the exercise of this Warrant; 
  
 (b) the issuance of this Warrant shall constitute full authority to the Corporation’s officers who are charged with the
duty of executing stock certificates to execute and issue the necessary certificates for the shares of Warrant Stock issuable upon exercise of this Warrant; 
  
 (c) the Corporation has all requisite legal and corporate power to execute and deliver this Warrant, to sell and issue the Warrant Stock hereunder, and to
carry out and perform its obligations under the terms of this Warrant; 
  
 (d) all corporate action on the part of the Corporation, its directors and stockholders necessary for the authorization, execution, delivery and performance of this Warrant by the Corporation, the authorization, sale, issuance and delivery
of the Warrant Stock, the grant of registration rights as provided herein and the performance of the Corporation’s obligations hereunder has been taken; 
  

(e) the Warrant Stock, when issued in compliance with the provisions of this Warrant and the Corporation’s Certificate of Incorporation (as they
may be amended from time to time), will be validly issued, fully paid and nonassessable, and free of all taxes, liens or encumbrances with respect to the issue thereof, and will be issued in compliance with all applicable federal and state
securities laws; 
  
 (f) and the issuance of the Warrant Stock
will not be subject to any preemptive rights, rights of first refusal or similar rights. 
  
 14. Governing Law. 
  
 This Warrant shall be governed by and construed in accordance with the laws of the State of California. 
  

 6 








 IN WITNESS WHEREOF, the Corporation has caused this Warrant to be executed by its duly authorized
officers. 
  
 Dated: October 29, 2003 
  
 ARBIOS TECHNOLOGIES, INC. 

		
	 By:
	 	

	 	 	 Jacek Rozga, M.D. President & Chief
 Scientific Officer


  

 7 








 NOTICE OF EXERCISE 
  
 To: Arbios Technologies, Inc. 
  
 (1) The undersigned hereby elects to purchase shares of common stock of Arbios Technologies, Inc. pursuant to the terms of the attached Warrant and
tenders herewith payment of the purchase price in full, together with all applicable transfer taxes, if any. 
  
 (2) In exercising this Warrant, the undersigned hereby confirms and acknowledges that the shares of common stock to be issued upon exercise hereof are
being acquired solely for the account of the undersigned and not as a nominee for any other party, and for investment and that the undersigned will not offer, sell or otherwise dispose of any such shares of common stock except under circumstances
that will not result in a violation of the Securities Act of 1933, as amended, or any state securities laws. 
  
 (3) Please issue a certificate or certificates representing said shares of common stock in the name of the undersigned or in such other name as is
specified below: 
  

	
	
 (Name)
  

 (Address)


  
 (3) The undersigned
represents that (a) he, she or it is the original purchaser from the Corporation of the attached Warrant or an ‘accredited investor’ within the meaning of Rule 501(a) under the Securities Act of 1933, as amended and (b) the aforesaid
shares of common stock are being acquired for the account of the undersigned for investment and not with a view to, or for resale in connection with, the distribution thereof and that the undersigned has no present intention of distributing or
reselling such shares. 
  

		
	 Date:
	 	  


	  

 (Signature)


  

 8