### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON , D.C. 20460

March 4 , 2015 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREV ENTION 

### Office of Pesticide Programs Registration Division (7505P)

MEMORANDUM DER for acute toxicity studies for 100-RUAA Subject: N ame ofthe Product SYN-A 19707 EPA File Symbol: 100-RUAA DP Barcode 411844 Decision No 470872 Action Code: RO 10 PC Code: 018986 From: 

# -v **~ ~**  Princess Campbell , DVM, MS, DACVPM ..\.__

__ . \ C ITAB John Redden , M.S. _) (
. 

# rL. CITAB Through: Registration Division (7505P) T o: Grant Rowland/Kathryn Montague RM 2 3 Herbicide Branch Registration Division (7505P) Applicant: Syngenta Crop Protection , LLC. Greensboro , NC 27419 FORMULATION FROM LABEL: Active Ingredient( s): S-Metolachlor Atrazine Meso tr ione Bicyclopyrone Other lngredient(s): Total: %by wt. 

### 23.40 10.93

2.60 0.65 62.42 

## 100.0Bicyclopyrone (A19707) Reviewer: Princess Campbell, DVM



### BACKGRO UN D : Syngenta Cro p Protection , LLC has submitted a set of six acute toxicity studies to support the reg i stration of Bicyclopyrone , an herbicide. T he toxicity studies were performed by RCC Ltd , Wolferstrasse 4, Switzerland , and Safeph arm between 2007 and 2008 (MRlDs 47841966 -71 ). Deficienci es : A ll studies are in compl iance with EPA guidelines; any deficienc y is not signifi cant and does not affect the outcome of the study . 

## FINDINGS: All six studies have b een classified as acceptab le. The toxicology profile is as fo ll ows: Acute ora l toxicity IV accep table Acute d ermal toxicity IV acceptable Acute inhalation IV acceptable Primary eye irritation IV acceptable Primary dermal irritation IV acceptable Dermal sensi ti zation

- ve acceptable

2 

### MRID 47841966 MRID 47841967 MRID 47841968 MRJD 47841970 MRID 4 7841969 MRID 4784197 1Bicyclopyrone (A19707) Reviewer: Princess Campbell, DVM


### LAB E L: PRODUCT 

### ID #: 000100-01466 PRODUCT NAME: SYN-A19707 PRECAUTIONARY STATEMENTS SIGNAL WORD: CAUTION Hazards to Humans and Domestic Animals: Wear: Long-sleeved shirt and long pants, 

### Socks, Shoes, and chemical-resistant gloves (such as Natural Rubber, Selection Category A).
User Safety Recommendations: Users sho uld remove clothing/PPE immediately if pesticide gets inside

. Then wash thoroughly and put on clean clothing. Users s hould remove PPE immediately after handling this product. Wash the outside of gloves before remov i ng. 

### As soon as possible, wash thoroughly and change into clean clothing

.

3Bicyclop yrone (Al9707) Reviewer: P rincess Campbell, DVM

**DER

**~** F"l S b I 100 RUA or 1 e ;ym o 

# - A l. DP BARCODE: 411844 2. PC CODE: 0 1 8986 3
. CURRENT DATE: February 4 , 2015 4. TEST ARTICLE : NOA449280; Batch # : SEZ3AP006/MILLED; Solid beige powder; Study /S pecies/Lab MRID Res u lts Tox Core Study #/Date Cat Grade Acute oral toxicity 

### I rat 4784 1966 LDso females is > 5000 mgfkg mg/ kg 

### rv A RCC Ltd /835493 / 07-05-2007 OCSPP 870.11 00; OECD 425

Acute dermal toxicity /rat 47841967 Dermal LD so Males/ females > 5000 I V A I RCC Ltd /835504/ 07-17-2007 mgfkgbw OCSPP 870.1200; OECD 402 Acute inha l ation toxicity I rat 47841968 LCso Males and females 

### > 5.2 10 mg/L IV A RCC Ltd /845145/ 05-08-2008 MMAD= 3.10 1-1m OCSPP 870.1300 ; OECD 403 GSD = 3
.22 All survived exposure (nose only). Primary Skin irritation I rabbit 47841969 Non irritating IV A RCC Ltd/835515 / 05- 11 -2007 OCSPP 870.2400; OECD 404 Primary eye irritation I rabbit 47841970 Non irritating IV A RCC Ltd 1 835526 107- 03-2007 OCSPP 870.2500; OECD 405 Dermal sensitization I mo u se LLNA- 4784197 1 Negative

. 

# -- A Safepharm Laboratories Ltd Positive control (15% HCA): /2364/ 0053 /01-08-2008 OCSPP 870.2600 Core Grade Key: A = Acceptab le, S = Supplemen tary , U = Unacceptable, D =Data Gap **Detailed DER completed for acute toxicity studies (6 pack) 

### in Global J oint Revi ew format.

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