Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D407350

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND

 POLLUTION PREVENTION

MEMORANDUM

Date: November 12, 2013

Subject: Chlorantraniliprole. Petition for the Establishment of Permanent Tolerances and 

Registration for Use on Peanuts and on Green Onion, Addition of Use on Greenhouse 

Tomato and Greenhouse Pepper and Greenhouse Cucumber, Crop Group 

Conversions for Stone Fruit and Tree Nuts, and Label Amendment to Shorten the PHI 

for Passionfruit, Papaya, and Mayhaw. Condition of Registration Data for Rice, 

Crayfish, Coffee, Strawberry, and Livetock Analytical Methods. Summary of 

Analytical Chemistry and Residue Data.

PC Code: 090100 DP Barcode: D407350; D416101

Decision No.: 476038; 477960; 477964; 477967; 

477972; 477962 ; 477952; 477965; 477970; 

477963; 477954; 477966; 477971; 417413

Registration No.: 352-728; 352-729; 352-730; 

352-820; 352-841; 352-838; 352-

844

Petition Nos.: 3E8170; 3F8158

Regulatory Action: Section 3 Registration 

Risk Assessment Type: NA Case No.: N/A

TXR No.: NA CAS No.: 500008-45-7

MRID No.: See Below 40 CFR§180.628

From: Steve Funk, Senior Chemist

Risk Assessment Branch III (RAB III)

Health Effects Division (HED; 7509P)

Through: Christine Olinger, Branch Chief

Risk Assessment Branch III (RAB III)

Health Effect Division (HED; 7509P)

To: Venus Eagle/Jennifer Urbanski, RM 01

Registration Division (RD; Mail Stop 7505P)

And

Barbara Madden/Laura Nollen, MR 05

Registration Division (RD; Mail Stop 7505P)
Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D407350

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OCSPP 860 

Series Guideline

MRID Number Title

860.1340 48930702 Vogl, E.; Stry, J. (2012) Analytical Method for the Determination of 

Chlorantraniliprole and IN-ECD73 in Crayfish Using LC/MS/MS. Project 

Number: DUPONT/31473/OCR, ABC/66393/M. Unpublished study 

prepared by ABC Laboratories, Inc.

860.1340 48930705 Henze, R.; Wadsley, M.; Stry, J. (2011) Analytical Method for the 

Determination of Chlorantraniliprole and Metabolites in Poultry Tissues and 

Eggs Using LC/MS/MS. Project Number: DUPONT/31085/OCR. 

Unpublished study prepared by DuPont Crop Protection. 

860.1500 48930701 Rice, F. (2012) Magnitude of Chlorantraniliprole Residues in Rice and 

Crayfish Following Seed Treatment with Chlorantraniliprole (DPX-E2Y45) 

FS [50% (w/w)] - U.S., 2011 - 2012. Project Number: 

DUPONT/30021/OCR, ABC/66393. Unpublished study prepared by ABC 

Laboratories, Inc.

860.1500 48930707 Rice, F. (2012) Magnitude of Chlorantraniliprole Residues in Coffee 

Following Foliar Applications with Chlorantraniliprole (DPX-E2Y45) 

35WG - U.S., 2011. Project Number: DUPONT/30023/OCR, ABC/66392. 

Unpublished study prepared by ABC Laboratories, Inc. 

860.1500 48930708 Rice, F. (2012) Magnitude of Chlorantraniliprole Residues in Strawberries 

Following Foliar Applications with Chlorantraniliprole (DPX-E2Y45) 20SC 

[200 g/L (w/v);18.4% (w/w] - U.S. and Canada, 2011. Project Number: 

DUPONT/30024/OCR, ABC/66391. Unpublished study prepared by ABC 

Laboratories, Inc. 

860.1500 49076103 Dorschner, K. (2012) Chlorantraniliprole: Magnitude of the Residue on 

Cherry, Papaya and Lychee. Project Number: B10204/OCR, 

B10204/09/FLR18, B10204/09/FL69. Unpublished study prepared by 

University of Hawaii. 

860.1500 49076101 Dorschner, K. (2010) Chlorantraniliprole: Magnitude of the Residue on 

Greenhouse Cucumbers. Project Number: 10004/OCR, 10004/08/FLR07, 

08/MD21. Unpublished study prepared by University of 

Maryland/LESREC, Colorado State University and Interregional Research 

Project No. 4. 

860.1500 49076102 Dorschner, K. (2009) Chlorantraniliprol: Magnitude of the Residue on 

Greenhouse Tomato. Project Number: 09477/OCR, 09477/07/FLR09, 

09477/07/CO06. Unpublished study prepared by Colorado State University. 

860.1500 49076104 Dorschner, K. (2012) Chlorantraniliprole: Magnitude of the Residue on 

Green Onion (Fresh and Dried) and Dill Seed. Project Number: 

A10204/OCR, A10204/09/FLR17, A10204/09/CA/99. Unpublished study 

prepared by University of California.

860.1500 49071201 Rice, F. (2012) Magnitude of Chlorantraniliprole Residues in Peanuts 

Following Foliar Applications with Chlorantraniliprole (DPX-E2Y45) 20SC 

[200 g/L (w/v); 18.4% (w/w)] - U.S., 2011. Project Identification Numbers: 

DuPont-31666, ABC 66664. Unpublished study prepared by ABC 

Laboratories and E.I. du Pont de Nemours and Company
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Table of Contents

1.0 Executive Summary............................................................................................................ 5

2.0 Regulatory Recommendations............................................................................................ 5

2.1 Data Deficiencies/Data Needs.......................................................................................... 5

2.2 Tolerance Considerations................................................................................................. 5

2.2.1 Enforcement Analytical Method............................................................................... 6

2.2.2 Recommended Tolerances........................................................................................ 6

2.2.3 Revisions to Petitioned-For Tolerances.................................................................... 7

2.2.4 International Harmonization ..................................................................................... 7

3.0 Introduction......................................................................................................................... 8

3.1 Chemical Identity................................................................................................................ 8

3.2 Physical/Chemical Characteristics................................................................................... 9

3.3 Pesticide Use Pattern/Directions for Use (860.1200)..................................................... 10

4.0 Metabolite/Degradate Residue Profile.............................................................................. 12

4.1 Nature of the Residue..................................................................................................... 12

4.1.1 Summary of Plant Metabolism (860.1300)............................................................. 13

4.1.3 Summary of Confined Rotational Crops (860.l850)............................................... 14

5.1 Residue Analytical Methods (860.1340)........................................................................ 14

5.1.1 Data Collection Methods ........................................................................................ 14

5.1.2 Multi-Residue Methods (860.1360)........................................................................ 17

5.1.3 Tolerance Enforcement Methods............................................................................ 17

5.1.4 Submittal of Analytical Reference Standards (860.1650) ...................................... 18

5.2 Storage Stability (860.1380) .......................................................................................... 18

5.3.1 Crop Field Trials (860.1500) .................................................................................. 19

49071201.der ........................................................................................................................ 20

5.3.2 Field Rotational Crops (860.1900) ......................................................................... 29

5.3.3 Processed Food and Feed (860.1520)..................................................................... 30

5.3.4 Meat, Milk, Poultry and Eggs (860.1480) .............................................................. 31

5.3.4.1 Dietary Burden ................................................................................................ 31

5.3.4.2 Estimated Secondary Residues in Livestock ................................................... 31

5.3.5. Food Handling (860.1460)...................................................................................... 31

5.3.6 Water, Fish, and Irrigated Crops (860.1400).......................................................... 31

6.0 Tolerance Derivation ........................................................................................................ 32
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Appendix A. International Residue Limits Table ........................................................................ 34

Appendix B. OECD MRL Calculation Procedure Inputs/Outputs.............................................. 35

 
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1.0 Executive Summary

Adequate field trial data were submitted to support use on greenhouse tomato, greenhouse 

pepper, and greenhouse cucumber. The existing tolerances from field use cover the expanded use 

pattern. 

Condition of registration data submitted for field trials for rice, coffee, and strawberry confirm 

the existing tolerances. A study submitted as confirmatory data for crayfish supports a lowering 

of the crayfish tolerance.

A condition of registration requirement for an analytical method for data collection for poultry

commodities has been fulfilled. 

Condition of registration data on field trial residue decline for cherry, papaya, and leechee 

support existing tolerances for certain tropical fruits and allow for lowering of the PHIs from 10 

days to 1 day, with an increase in tolerance from 2 ppm to 4 ppm, for papaya and passionfruit.

Adequate field trial data were submitted to support new uses on peanuts and the green onion 

subgroup 3-07B.

Additional field trial data support an increase in the spice subgroup 19B tolerance.

Crop group conversions for the tree nut group, pome fruit group, and stone fruit group are 

acceptable. The tolerances for mayhaw and pistachio will be removed with their addition to the 

pomefruit and tree nut groups, respectively. 

2.0 Regulatory Recommendations

There are no residue chemistry considerations that would preclude granting the requested 

registration and establishing the recommended tolerances for chlorantraniliprole on peanuts and 

the green onion subgroup 3-07B. A modified Section F must be submitted to request a change 

in the crayfish tolerance to 0.01 ppm and a change in the spice subgroup 19B tolerance to 90 

ppm. Likewise, the requested crop group conversions are acceptable. Condition of registration 

requirements for field trials on strawberry, coffee, and rice have been fulfilled. A condition for 

registration requirement for crayfish trials has been fulfilled. A condition of registration 

requirement for an analytical method for data collection for poultry commodities has been 

fulfilled. The specific tolerance recommendations are discussed in 2.2, and label modifications 

are discussed in section 2.3

2.1 Data Deficiencies/Data Needs

There are no data deficiencies related to the present submission.

2.2 Tolerance Considerations
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2.2.1 Enforcement Analytical Method

An adequate enforcement method (liquid chromatography/tandem mass spectrometry

(LC/MS/MS), DuPont-11374) is available for the determination of chlorantraniliprole residues 

in/on plant commodities. The purified extract is analyzed by LC/MS/MS operating in the 

positive ionization mode. For the determination of chlorantraniliprole, the following ion 

transitions are monitored (m/z 484  453, 484  286, 284  112, 284  177). The limit of 

quantitation (LOQ) is reported at 0.01 ppm for parent chlorantraniliprole. The LC/MS/MS 

method was adequately validated on a variety of matrices: corn fodder, raisins, grapes, soybean 

seed, cotton gin trash, white rice, brown rice, tomato, bell pepper, lettuce, and tea leaves and an 

acceptable Independent Laboratory Validation (ILV) study was conducted on apples, wheat 

grain, and almond nutmeat. The method for the determination of chlorantraniliprole and its 

metabolites in processed commodities is a LC/MS/MS method, DuPont-14314, which is a 

slightly modified version of DuPont-11374. These methods have been accepted by the 

Analytical Chemistry Branch (ACB)/Biological and Economical Analysis Division (BEAD; 

DP#340358, C. Stafford, 02/06/2008).

An adequate enforcement method (LC/MS/MS) is available for the determination of residues of 

chlorantraniliprole and its metabolites in/on animal commodities. Atmospheric pressure 

chemical ionization (APCI) MS/MS detection operated in the positive ion mode is used. The 

LOQ is reported at 0.010 ppm for the parent and each of the metabolites. The method has been 

accepted by ACB/BEAD (DP#340358, C. Stafford, 02/06/2008).

2.2.2 Recommended Tolerances

The current tolerance definition is found at 40CFR§180.628. Compliance with the tolerance is 

based on measuring only chlorantraniliprole for both plant and animal commodities.

Table 2.2.2. Tolerance Summary for Chlorantraniliprole

Commodity Established/Proposed 

Tolerance (ppm)

HED-Recommended 

Tolerance (ppm)

Comments 

(correct commodity definition)

Papaya 2.0 4.0

Passionfruit 2.0 4.0

Peanut, nutmeat 0.06 0.06

Peanut, hay 0.20 (exp 04/10/14)

90 proposed

90 Translation from alfalfa hay

Onion, green, subgroup 

3-07B

3.0 3.0

Spice subgroup 19B 141established/40 

proposed

90

Nut, tree, group 14-12 0.04 0.02 Crop group conversion.

International harmonization.

Nut, tree, group 14 0.04 Remove Replaced by crop group 14-12

Pistachio 0.04 Remove Replaced by crop group 14-12

Fruit, pome, group 11-

10

1.2 1.2 Crop group conversion

Fruit, pome, group 11, 

except mayhaw

1.2 Remove Replaced by crop group 11-10
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Mayhaw 0.6 Remove Replaced by crop group 11-10

Fruit, stone group 12-

12, except cherry, 

Chickasaw plum, and 

damson plum

4.0 4.0 Crop group conversion

Fruit, stone group 12, 

except cherry, 

Chickasaw plum, and 

damson plum

4.0 Remove Replaced by crop group 12-12

Crayfish 8.0 0.01

Onion, green 0.20 (exp 04/10/14) Remove Replaced by Onion, green, 

subgroup 3-07B

Onion, welsh 0.20 (exp 04/10/14) Remove Replaced by Onion, green, 

subgroup 3-07B

Shallots, fresh leaves 0.20 (exp 04/10/14) Remove Replaced by Onion, green, 

subgroup 3-07B

Leek 0.20 (exp 04/10/14) Remove Replaced by Onion, green, 

subgroup 3-07B

1 A tolerance of 14 ppm was recommended (D361791, D. Rate, 01/08/2010), but is not listed in 40CFR§180.628. 

This was based on the translation of alfalfa seed data, with adjustments for adjuvant use (2x) and application rate 

(2x).

2.2.3 Revisions to Petitioned-For Tolerances

The petitioned tolerances are the same as the recommended tolerances, except for spice subgroup 

19B and crayfish. Residue data on dill seed was presented in support of a spice subgroup 19B 

tolerance. HED had previously recommended for a spice subgroup 19B tolerance of 14 ppm. 

The petitioner requested 40 ppm, but evaluation of the dill seed data indicates that 90 ppm is 

appropriate. See Appendix B.

A crayfish tolerance of 8 ppm was previously established based on a fish bioconcentration study

and the estimated residues in water, sediment, and rice straw. The present crayfish study showed 

no residues (<0.01 ppm) at various sampling intervals from the use of chlorantraniliprole as a 

seed treatment on rice. This reflects the actual use pattern. A tolerance of 0.01 ppm is 

appropriate. A modified Section F is required.

A crop group conversion for tree nut group 14 to tree nut group 14-2 was requested. This is 

acceptable, but the tolerance will be changed from 0.4 ppm to 0.2 ppm to harmonize with 

Canada and Codex.

The registrant must submit a revised Section F requesting tolerances of 90 ppm and 0.01 ppm 

for the spice subgroup 19B and crayfish, respectively.

2.2.4 International Harmonization

Residue definitions are harmonized among the US, Canada, and Codex, with the common 

definition chlorantraniliprole. Relevant maximum residue limits (MRLs) are summarized in the 

International Residue Limits (IRL) table in Appendix A.
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The existing US tolerance for the tree nut group is 0.04 ppm, whereas the tolerance in both 

Canada and Codex is 0.02 mg/kg. The US tolerance is based upon the evaluation of field trial 

data for pecans and almonds with the use of the North American Free Trade Agreement 

(NAFTA) statistical spreadsheet (N. Tsaur, D357727, 03/03/2009). The data were reevaluated 

using the current procedure, the OECD spreadsheet, as shown in Appendix B. The new tolerance 

estimate is 0.02 ppm. Therefore, the tolerance for tree nuts, including pistachio, is lowered to 

0.02 ppm, and harmonization with Canada and Codex is achieved.

The existing US tolerance for the pome fruit group is 1.2 ppm. The Codex MRL for pome fruit 

is 0.4 ppm, and the Canada MRL for various pome fruits (apple, pear, mayhaw, quince) is 0.4

ppm. The original US tolerance for pome fruits was 0.3 ppm, but it was adjusted upwards to 1.2 

ppm to accommodate the use of adjuvants and a shortened PHI (D361791, D. Rate, 01/08/2010). 

Therefore, the 1.2 ppm value cannot be lowered to harmonize with Codex and/or Canada.

The existing US tolerance for the stone fruit group (except cherry, chickasaw plum, and damson 

plum) is 4.0 ppm. The Codex MRL for stone fruits is 1 mg/kg and the Canada MRL for various 

stone fruits (apricot, nectarine, peach, plum, plumcots, cherries) is 2.5 mg/kg. The original US 

tolerance for stone fruits was 1.0 ppm, but it was adjusted upwards to 4.0 ppm to accommodate 

the use of adjuvants and a shortened PHI (D361791, D. Rate, 01/08/2010). Therefore, the 4.0 

ppm value cannot be lowered to harmonize with Codex and/or Canada.

Codex has not established MRLs for passionfruit, papaya, peanuts, green onions, herbs, or 

spices. Therefore, there is no harmonization issue with Codex. Canada does not have MRLs for 

these same commodities, with the exception of green onions and peanuts. Canada and the US 

are conducting a joint review for green onions and peanuts and have agreed upon harmonized

MRL values.

2.3 Label Recommendations

The proposed labels are acceptable.

3.0 Introduction

Chlorantraniliprole (DPX-E2Y45) is an anthranilic acid (or 2-aminobenzoic acid) diamide 

insecticide belonging to a class of compounds that acts on the ryanodine receptor. Section 3 

registrations of chlorantraniliprole for use in the United States have been approved for the 

numerous crop groups or crop subgroups and individual commodities. Chlorantraniliprole is 

registered to E.I. du Pont de Nemours and Company (DuPont). 

3.1 Chemical Identity
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Table 3.1. Chlorantraniliprole Nomenclature.

Chemical structure

Common name Chlorantraniliprole

Company experimental name DPX-E2Y45

IUPAC name 3-bromo-4′-chloro-1-(3-chloro-2-pyridyl)-2′-methyl-6′-(methylcarbamoyl)pyrazole-5-

carboxanilide

CAS name 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-

pyridinyl)-1H-pyrazole-5-carboxamide

CAS registry number 500008-45-7

End-use product (EP) DuPontTM Altacor® WG (35%; EPA Reg. No. 352-730)

DuPontTM Coragen® SC Insect Control (1.67 lb ai/gal; EPA Reg. No. 352-729)

DuPontTM Dermacor® X-100 Seed Treatment (FS, 5.21 lb ai/gal; EPA Reg No. 352-820)

3.2 Physical/Chemical Characteristics

The log octanol/water partition coefficient is <3 over a range of pHs, suggesting that 

chlorantraniliprole is not highly soluble in fat-type matrices and hydrocarbon solvents. This is 

confirmed by the solubility data in water and various organic solvents. The low vapor pressure 

means low volatility.

Table 3.2. Physicochemical Properties of Technical Grade of Chlorantraniliprole.

Parameter Value Reference

Melting point/range (°C) 200-202 (95.9%)/208 – 210 (99.2%) 46889033

pH 5.77 ± 0.087 at 20°C 46889031

Relative Density 1.5189 (95.9%)/1.507 (99.2%) at 20°C 46889033

Water solubility (20°C) Deionized Water 1.023 mg/L

pH 4 0.972 mg/L

pH 7 0.880 mg/L

pH 9 0.971 mg/L

46889026

Solvent solubility (20°C) Acetone 3.446 ± 0.172 g/L

Acetonitrile 0.711 ± 0.072 g/L

Ethyl Acetate 1.144 ± 0.046 g/L

Dichloromethane 2.476 ± 0.058 g/L

Dimethylformamide 124 ± 4 g/L

n-Octanol 0.386 ± 0.01 g/L

Methanol 1.714 ± 0.057 g/L

n-Hexane <0.0001 g/L

o-Xylene 0.162 ± 0.01 g/L

46889030

N

N N

NH

O

Cl

Br

HN

O

Cl
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Table 3.2. Physicochemical Properties of Technical Grade of Chlorantraniliprole.

Parameter Value Reference

Vapor pressure 6.3 x 10-12 Pa @ 20°C, 2.1 x 10-11 Pa @ 25°C 46889130

Dissociation constant, pKa 10.88 ± 0.71 46889034

Octanol/water partition 

coefficient, KOW (20°C)

Deionized Water 589 

pH 4 588

pH 7 721 (log 2.8)

pH 9 654

46889032

UV/visible absorption (max) pH <2 no absorption max >200 nm, at 290 ε = 3941

pH 7 no absorption max >200 nm, at 290 ε = 4185

pH >10 absorption max at ~320 nm which may be

due to decomposition of DPX-E2Y45, at 290 ε = 6082

46889027

3.3 Pesticide Use Pattern/Directions for Use (860.1200)

Table 3.3. Summary of Proposed Directions for Use of Chlorantraniliprole

Applic. 

Timing, Type, 

and Equip.

Formulation

[EPA Reg. 

No.]

Applic. Rate 

(lb ai/A)

Max. 

No. 

Applic. 

per 

Season

Max. Seasonal 

Applic. Rate

(lb ai/A)

PHI

(days)

Use Directions and 

Limitations

Peanut

Foliar

(ground; 

aerial)

18.4% SC

1.67 lb 

ai/gal

Coragen

(352-729)

0.045 –

0.065 4

0.2 (from all 

chlorantraniliprole sources)1

Minimum interval 

between treatments is 3 

days.

Foliar

(ground; 

aerial)

5% SC

0.43 lb 

ai/gal

Prevathon

(352-844)

0.047-0.067 4

0.2 (from all 

chlorantraniliprole sources)1

Minimum interval 

between treatments is 3 

days.

Bulb Vegetables (including green onion subgroup)

Foliar

(ground; 

aerial)

18.4% SC

1.67 lb 

ai/gal

Coragen

(352-729)

0.045 –

0.065 4

0.2 per crop

0.6 per year

(from all 

chloroantranili

-prole sources)

1

Minimum interval 

between treatments is 4 

days.

Greenhouse Cucumbers, Greenhouse Peppers, Greenhouse Tomatoes

Foliar

18.4% SC

1.67 lb 

ai/gal

Coragen

(352-729)

0.031 

tomato

0.045 

pepper, 

cucumber

3 (per 

crop 

cycle)

0.134 per crop 

cycle 1

Minimum interval 

between treatments is 7 

days.

Mix 1.6 fl oz per 100 gal 

spray volume (0.0209 lb 

ai/100 gal)

Maximum application is 

150 gal spray solution 

per acre for tomato and 

214 gal spray solution 

per acre for cucumber 

and pepper.

Tropical Fruits

Foliar 35.0% 0.066- 0.099 3 0.2 (from all 1

1 Minimum interval 
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Table 3.3. Summary of Proposed Directions for Use of Chlorantraniliprole

Applic. 

Timing, Type, 

and Equip.

Formulation

[EPA Reg. 

No.]

Applic. Rate 

(lb ai/A)

Max. 

No. 

Applic. 

per 

Season

Max. Seasonal 

Applic. Rate

(lb ai/A)

PHI

(days)

Use Directions and 

Limitations

WDG

Altacor

(352-730)

chloroantranili

-prole sources) 10 

(acerol

a, 

jabotic

aba, 

and 

lychee

)

between treatments is 7 

days.

Do not apply dilute 

solutions of more than 

200 gal water per acre.

Do not apply less than 

30 gal water per acre

Low growing berry (subgroup 13-07G)

Foliar

35.0% 

WDG

Altacor

(352-730)

0.066-0.099 3

0.2 (from all 

chloroantranili

-prole sources)

1

Minimum interval 

between treatments is 7 

days.

Do not apply dilute 

solutions of more than 

200 gal water per acre.

Do not apply less than 

30 gal water per acre.

Do not apply to 

strawberry or cranberry.

Foliar

18.4% SC

1.67 lb 

ai/gal

Coragen

(352-729)

0.045-0.065 4

0.2 per crop 

(from all 

chloroantranili

-prole sources)

0.4 per year 

(from all 

chloroantranili

-prole sources)

1

Minimum interval 

between treatments is 7 

days.

Rice

Seed treatment

50% FS

5.21 lb 

ai/gal

Dermacor 

X-100

0.084 1 N/S N/S

Do not use 

DERMACOR® X-100 

treated rice field

for the aquaculture of 

edible fish or Crustacea

(including crawfish) 

during the rice 

production cycle

(planting through 

harvest).

Coffee

Foliar

35.0% 

WDG

Altacor

(352-730)

0.066-0.099 3

0.2 (from all 

chloroantranili

-prole sources)

7

Minimum interval 

between treatments is 

14days.

Do not apply dilute 

solutions of more than 

200 gal water per acre.

Do not apply less than 
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Table 3.3. Summary of Proposed Directions for Use of Chlorantraniliprole

Applic. 

Timing, Type, 

and Equip.

Formulation

[EPA Reg. 

No.]

Applic. Rate 

(lb ai/A)

Max. 

No. 

Applic. 

per 

Season

Max. Seasonal 

Applic. Rate

(lb ai/A)

PHI

(days)

Use Directions and 

Limitations

30 gal water per acre.

Herb Subgroup 19A

Foliar

18.4% SC

1.67 lb 

ai/gal

Coragen

(352-729)

0.045 –

0.065 4

0.2 per crop 

(from all 

chloroantranili

-prole sources)

0.8 per year 

(from all 

chloroantranili

-prole sources)

1

Minimum interval 

between treatments is 3 

days.

Spices Subgroup 19B

Foliar 

18.4% SC

1.67 lb 

ai/gal

Coragen

(352-729)

0.045 –

0.065 4

0.2 per crop 

(from all 

chloroantranili

-prole sources)

0.8 per year 

(from all 

chloroantranili

-prole sources)

1

Minimum interval 

between treatments is 3 

days.

1The PHI for papaya and passionfruit has been reduced from 10 days to 1 day.

Conclusions. 

The label information is adequate to allow evaluation of the residue data relative to the proposed 

uses. No label changes are needed for the uses presented in Table 3.3.

4.0 Metabolite/Degradate Residue Profile

4.1 Nature of the Residue

The nature of the residue in plants is adequately understood. HED has determined that parent 

chlorantraniliprole is the residue of concern in plant commodities for tolerance expression and 

risk assessment (DP#343519, C. Olinger, 02/29/2008).

The HED’s ROCKS (DP#343519, C. Olinger, 02/29/2008) previously determined that the 

residue of concern in ruminants is chlorantraniliprole for the purposes of the tolerance 

expression. ROCKS also determined that the residue of concern in ruminants is 

chlorantraniliprole for the purposes of risk assessment, unless the level of the dietary burden 

significantly increased. With an increase of dietary burden of ruminants, for risk assessment 

purposes, the following metabolites are now included: IN-HXH44 and IN-K9T00. Upon 

consultation with members of ROCKS, the chlorantraniliprole risk assessment team previously 

determined that the residue of concern for the tolerance expression in poultry is 

chlorantraniliprole and that metabolites (IN-H2H20, IN-K7H29 and IN-GAZ70) would be 
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included with chlorantraniliprole in the risk assessment for eggs. However, the poultry feeding 

study revealed concentrations of metabolites IN-H2H20, IN-F9N04, IN-K7H29, and IN-GAZ70 

often equal to the concentration of chlorantraniliprole in liver, eggs, meat, and fat (with skin). 

These metabolites are structurally similar to the parent (Appendix I). Therefore, the residue 

definition for dietary risk assessment in poultry commodities was altered to be the sum of 

chlorantraniliprole and metabolites IN-H2H20, IN-F9N04, IN-K7H29, and IN-GAZ70, 

calculated as chlorantraniliprole (D404708, S. Funk, 09/10/2013). 

4.1.1 Summary of Plant Metabolism (860.1300)

Studies have been conducted depicting the metabolism of chlorantraniliprole in apple, cotton, 

lettuce, rice, and tomato (DP#336941, L. Cheng, 02/25/2008). In the apple, cotton, lettuce and 

tomato studies, the plants were treated at 3 x 100 g ai/ha by foliar application (~ 0.5x proposed 

maximum application rate), and rice was treated at 1 x 150 g ai/ha by soil drench (0.68x, based 

on the proposed Section 18 use). Total radioactive residues were measured in apples (0.092 and 

0.138 ppm at 15- and 30-day PHIs, respectively), lettuce (0.301 and 0.372 ppm at 7- and 15-day

PHIs, respectively), cottonseed (<0.01 ppm at 126-day PHI), tomato (0.056 and 0.013 ppm at 7-

and 15-day PHIs, respectively), and rice (0.155 ppm at 132-day PHI). For apple, lettuce and 

tomato, the majority of the residues were surface residues. In all these crops, unchanged 

chlorantraniliprole was the major residue (57-92% of the total radioactive residue (TRR)).

Very little degradation of chlorantraniliprole was observed in apple, cotton, lettuce and tomato. 

Many metabolites were found in rice commodities and the metabolism in rice generally involves: 

(i) hydroxylation of the N-methyl group (to IN-H2H20) or hydroxylation of the tolyl methyl 

group (to IN-HXH44); (ii) cyclization with loss of water to a quinazolinone derivative (INEQW78); and similar condensation of IN-H2H20 with an additional loss of CH2O (to INGAZ70); and (iii) N-demethylation via IN-H2H20 to IN-F9N04. 

4.1.2 Summary of Livestock Metabolism (860.1300)

DP#343519, C. Olinger, 2/29/2008 (Residues of Concern Knowledgebase Subcommittee)

DP#336941, L. Cheng, 2/25/2008 (PP#7F7181)

DP#361791, D. Rate, 01/08/2010 (PP#9F7513)

Adequate metabolism studies with chlorantraniliprole in hens and goats have been reviewed 

(DP#336941, L. Cheng, 02/25/2008). The metabolic fate of chlorantraniliprole in livestock was 

investigated by the conduct of radiolabeled studies in laying hens and lactating goats. 

Following oral administration to laying hens, chlorantraniliprole and its metabolites were 

eliminated in the excreta (>98% of the dose). Eggs and edible tissues contained approximately

3% of the total administered dose. The major components of the radioactivity in eggs were 

parent chlorantraniliprole (12-23% TRR in egg yolk; 26-32% TRR in egg white) and IN-GAZ70 

(4-7% TRR in egg yolk; 33-40% TRR in egg white); and parent chlorantraniliprole was the 

major component in skin with fat (18% TRR). Chlorantraniliprole was also detected in liver (4% 

TRR) and muscle (4% TRR). The poultry feeding study, reviewed below, revealed significant 

concentrations of several metabolites in poultry commodities.

When 14C-chlorantraniliprole was orally administered to a lactating goat at 10 ppm in the feed, a 
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large proportion of the dose was eliminated in the excreta (93.57% of the dose). Milk, liver, and 

kidney combined contained approximately 1% of the administered total dose. Parent 

chlorantraniliprole was the major component of the extracted radioactivity identified in kidney, 

muscle, and fat samples and was also identified in liver. The radioactivity in fat was higher than 

in muscle, indicating that chlorantraniliprole and its residues are likely to be designated as “fatsoluble.”

The entire radioactivity in milk was extracted. Three metabolites were identified in addition to 

chlorantraniliprole in the extracts. Unchanged parent compound accounted for 23.58% TRR 

(0.016 ppm, 0.19% dose). The three metabolites were IN-K9T00 at 26.1% TRR (0.017 ppm, 

0.21% dose), IN-HXH44 at 26.92% TRR (0.018 ppm, 0.21% dose), and IN-HXH40 at 5.87% 

TRR (0.004 ppm; 0.05% dose).

4.1.3 Summary of Confined Rotational Crops (860.l850)

DP#336941, L. Cheng, 2/25/2008 (PP#7F7181)

Acceptable confined rotational crop studies have been reviewed and deemed adequate to satisfy

data requirements. Unchanged parent was the major identified residue in all rotational crop 

commodities including lettuce (64-85% TRR), wheat grain (48% TRR from an exaggerated rate 

at 120 DAT), wheat forage (54-84% TRR), wheat hay (51-73% TRR), and wheat straw (37-69% 

TRR); TRR were <0.01 ppm in wheat grain, beet root, and beet foliage. HED (DP#343519, C. 

Olinger, 2/29/2008) has determined that the parent compound is the residue of concern in 

rotational crops for the purposes of tolerance expression and risk assessment. 

5.1 Residue Analytical Methods (860.1340)

5.1.1 Data Collection Methods

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LC/MS/MS method DuPont-13294, a modification of the enforcement method, was utilized for 

the analysis of chloranatranilirprole in plant commodities. Briefly, samples were hydrated and 

then extracted twice with acetonitrile (ACN) and filtered. An aliquot of the extract was 

evaporated to dryness under a stream of nitrogen, reconstituted in ACN:water (40:60, v:v), and 

filtered for analysis by LC/MS/MS. The LOQ (determined as the LLMV) was 0.01 ppm for 

chlorantraniliprole in/on cucumbers, tomato, green onion, strawberry, peanut, lychee, cherry, 

papaya, and rice grain . 

In this submission, E.I. du Pont de Nemours and Company (DuPont) has provided validation data 

for analytical method 31085 for the determination of residues of chlorantraniliprole and 

metabolites IN-H2H20, IN-F9N04, IN-K7H29, IN-GAZ70, and IN-EQW78 in poultry tissues 

and eggs. This is a data collection method.

Briefly, homogenized samples are extracted once with water, acetonitrile (ACN), and hexane and 

once with ACN and hexane using a Genogrinder. After centrifugation, the ACN layers are 

combined and diluted to volume with ACN. For egg commodities (whole egg, egg white, and 
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egg yolk), an aliquot is evaporated to dryness and redissolved in ACN, methanol, and water for 

analysis by liquid chromatography/tandem mass spectrometry (LC/MS/MS). For poultry tissues, 

an aliquot is cleaned up on an Oasis Hydrophobic-Lipophilic Balance (HLB) solid-phase 

extraction (SPE) cartridge using ACN followed by 0.5% formic acid in ethyl acetate to elute 

residues; the eluate is diluted to volume with ACN, and an aliquot is evaporated to dryness and 

redissolved in ACN, methanol, and water for analysis by LC/MS/MS. LC/MS/MS analysis is 

conducted in the positive ion mode monitoring at least two ion transitions for each analyte; one 

ion transition is used for quantitation and the relative ratio of the fragment ions is used for 

confirmation of analyte presence.

The method included an alternate extraction procedure for egg commodities. Homogenized egg 

samples are mixed with water and extracted with ACN and hexane using a homogenizing probe. 

After centrifugation, the ACN layer is removed and the remaining hexane and solids are 

extracted with ACN using the homogenizing probe. The mixture is centrifuged and the ACN 

layers are combined and diluted to volume with ACN. An aliquot is mixed with concentrated 

formic acid and then evaporated to dryness and redissolved in ACN, methanol, and water for 

LC/MS/MS analysis.

The method using the Genogrinder extraction was validated with samples of whole eggs, poultry

muscle, poultry liver, and poultry fat fortified with chlorantraniliprole and metabolites INH2H20, IN-F9N04, IN-K7H29, IN-GAZ70, and IN-EQW78 at 0.010 and 0.10 ppm each. 

Reasonably acceptable method validation recoveries were obtained for all analytes in every

matrix using this method. Recoveries [and coefficients of variation (CVs)] of 

chlorantraniliprole, IN-H2H20, IN-F9N04, IN-K7H29, IN-GAZ70, and IN-EQW78 ranged from 

80-120% (2.0-8.3%) in whole eggs; from 89-123% (1.6-13.9%) in muscle; from 85-116% (2.7-

9.6%) in liver; and from 83-157% (1.2-9.2%) in fat. With few exceptions, individual recoveries 

were within the acceptable range of 70-120%. High recoveries were obtained for 

chlorantraniliprole from fat (all samples; 122-157%), for IN-H2H20 from muscle (121%), and 

for IN-F9N04 from muscle (123%).

The method using the homogenizing probe was validated with samples of whole eggs, egg 

whites, and egg yolks fortified with chlorantraniliprole and metabolites IN-H2H20, IN-F9N04, 

IN-K7H29, IN-GAZ70, and IN-EQW78 at 0.010 and 0.10 ppm each. Reasonably acceptable 

method validation recoveries were obtained for all analytes using this method. Recoveries (and 

CVs) of chlorantraniliprole, IN-H2H20, IN-F9N04, IN-K7H29, IN-GAZ70, and IN-EQW78 

ranged from 81-128% (4.3-14.8%) in whole eggs; from 74-122% (2.2-17.2%) in egg whites; 

from 87-127% (1.9-10.7%) in egg yolks. High recoveries were obtained for chlorantraniliprole 

from egg yolks (127%), for IN-GAZ70 from whole eggs (122, 128, and 128%), and for INF9N04 from egg whites (122%).

The limit of quantitation (LOQ), based on the lowest level of method validation (LLMV), is 

0.010 ppm for each analyte in each matrix.
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In this submission, DuPont provided a data collection method (DuPont 31473) for the 

determination of chloranatraniliprole and metabolite IN-ECD73 in crayfish. The method is 

similar to the livestock commodity enforcement method.

Briefly, samples are extracted once with purified water, acetonitrile (ACN), and hexane by 

shaking. After centrifugation, the lower ACN/water layer is extracted again using ACN, and any

remaining hexane is removed from the combined ACN/water layers by nitrogen evaporation. 

The extract is diluted to volume with ACN, and an aliquot is mixed with ACN:0.01 M aqueous 

formic acid (75:25, v:v). The extract is filtered through a 0.45-μm polytetrafluoroethylene 

syringe filter for analysis by liquid chromatography/tandem mass spectrometry (LC/MS/MS). 

LC/MS/MS analysis is conducted in the positive ion mode, monitoring ion transitions amu 484.0 

to 286.0 for chlorantraniliprole and 279.2 to 244.0 for IN-ECD73.

The method was validated with samples of crayfish fortified at 0.010 and 0.100 ppm for both 

chlorantraniliprole and IN-ECD73. Acceptable method validation recoveries were obtained. 

Recoveries of chlorantraniliprole and IN-ECD73 ranged from 83-103% (average of 95% and 

standard deviation of 6%) and from 82-105% (average of 92% and standard deviation of 6%), 

respectively. Individual recoveries at each fortification level were within the acceptable range of 

70-120%, and coefficients of variation (CVs) ranged from 1.2-10%.

The limit of quantitation (LOQ), based on the lowest level of method validation (LLMV), is 

0.010 ppm for each analyte.

The solvents used for the extraction of samples in this method are the same as those used in the 

crayfish toxicity study (DuPont Report No. 24137). Therefore, radiovalidation data for this 

method are not required.

Conclusions.

For data collection, LC/MS/MS method DuPont-13294 was used for the analysis of 

chlorantraniliprole residues in samples from the field trial studies submitted in conjunction with 

the subject petitions. The adequacy of data-collection methods was verified with method 

recoveries in the acceptable 70-120% range.

DuPont-31085 was utilized for the analysis of samples from a poultry feeding study. The 

adequacy of data-collection methods was verified with method recoveries in the acceptable 70-

120% range, except as noted above.

Method DuPont 31473 is acceptable as a data collection method for residues of 

chlorantraniliprole and IN-ECD73 in crayfish. The limits of quantitation (LOQs), based on the 

lowest levels of method validation (LLMVs), were 0.010 ppm for chlorantraniliprole in crayfish 

and 0.010 ppm for IN-ECD73 in crayfish. The method was adequate for data collection based on 

acceptable concurrent recoveries, as well as method validation for both analytes in crayfish. The 

method may be used for enforcement of tolerance purposes, based on its similarity to the 

livestock enforcement method (DuPont 11376). An ILV study is not required.
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5.1.2 Multi-Residue Methods (860.1360)

DP#336941, L. Cheng, 2/25/08 (PP#7F7181)

Multiresidue data for chlorantraniliprole are available. The study evaluated chlorantraniliprole 

using the appropriate FDA multiresidue methods as outlined in the FDA Pesticide Analytical 

Manual, Volume I, Third Edition (January 1994). Testing of Protocol A was not conducted 

since chlorantraniliprole does not naturally fluoresce. Protocol B was not tested since 

chlorantraniliprole does not contain a carboxylic acid or phenolic group. When subjected to 

Protocol C testing, chlorantraniliprole yielded multiple peaks on different columns and detectors. 

The recovery of chlorantraniliprole through Protocol D could not be quantified because of matrix 

interference. No or low recoveries of chlorantraniliprole were observed through Protocol E and 

F. Protocol G was not tested since chlorantraniliprole does not contain a substituted urea 

function.

Conclusions. The requirements for multiresidue methods data are fulfilled. Chlorantraniliprole 

is not recovered by the US FDA’s multiresidue methods.

5.1.3 Tolerance Enforcement Methods

DP#345790, L. Cheng, 11/6/2007 (PP#7F7181; PMV Request)

DP#340358, C. Stafford, 2/6/2008 (ACB/BEAD)

DP#336941, L. Cheng, 2/25/2008 (PP#7F7181)

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An adequate enforcement method (LC/MS/MS, DuPont-11374) is available for the 

determination of chlorantraniliprole residues in/on plant commodities. Briefly, samples are 

soaked in water before extraction with acetonitrile (ACN). An aliquot of the extract is diluted 

with water, filtered through a strong anion exchange (SAX) solid phase extraction (SPE) 

cartridge connected in series with an Oasis hydrophilic-lipophilic balanced (HLB) cartridge. 

After washing the cartridges with water/acetonitrile, the cartridges are air dried, and the Oasis 

cartridge is separated from the SAX cartridge. Chlorantraniliprole is eluted from the Oasis 

cartridge with acetone. The eluant is evaporated to dryness and the residue is reconstituted in 

ACN and diluted with water. The extract is analyzed by LC/MS/MS operating in the positive 

ionization mode. For the determination of chlorantraniliprole, the following ion transitions are 

monitored (m/z 484  453, 484  286, 284  112, 284  177). The LOQ is reported at 0.01 

ppm for parent chlorantraniliprole. The LC/MS/MS method was adequately validated on a 

variety of matrices: corn fodder, raisins, grapes, soybean seed, cotton gin trash, white rice, 

brown rice, tomato, bell pepper, lettuce, and tea leaves and an acceptable ILV study was 

conducted on apples, wheat grain, and almond nutmeat. The method for the determination of 

chlorantraniliprole and its metabolites in processed commodities is an LC/MS/MS method, 

DuPont-14314, which is a slightly modified version of DuPont-11374. These methods have 

been accepted by the Analytical Chemistry Branch (ACB)/Biological and Economical Analysis 

Division (BEAD; DP#340358, C. Stafford, 02/06/2008).

An adequate enforcement method (LC/MS/MS, Du[pont 11376)) is available for the 

determination of residues of chlorantraniliprole and its metabolites in/on animal commodities. 

Atmospheric pressure chemical ionization (APCI) MS/MS detection operated in the positive ion 
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mode is used. The LOQ is reported at 0.010 ppm for the parent and each of the metabolites. The 

method has been accepted by ACB/BEAD (DP#340358, C. Stafford, 02/06/2008).

Conclusions.

Adequate methods are available for the enforcement of tolerances for chlorantraniliprole residues 

in/on crops (LC/MS/MS Method DuPont-11374) and livestock (LC/MS/MS; MRID 46889003). 

The LOQs are 0.01 ppm for chlorantraniliprole in crop and livestock matrices. 

5.1.4 Submittal of Analytical Reference Standards (860.1650)

The analytical reference standard is available from the EPA National Pesticide Standards 

Repository. It expires 04/24/2014.

5.2 Storage Stability (860.1380)

Adequate storage plant commodity stability studies were previously submitted in conjunction 

with PP#7F7181 (DP#336941, L. Cheng, 2/25/2008). The study results demonstrate that 

residues of chlorantraniliprole are reasonably stable at approximately -20C for at least 24 

months in diverse crops (apple, grape, tomato, leaf lettuce, cauliflower, potato, wheat grain, 

wheat straw, alfalfa hay, and cotton seed), including water-, oil-, protein-, and starch-containing 

commodities as represented by fruits, a fruiting vegetable, a root crop, a non-oily grain, and an 

oilseed. Additional study results demonstrate that residues of chlorantraniliprole and its 

metabolites (IN-ECD73, IN-EQW78, and IN-F6L99) are stable for at least 12 months in 

processed crop fractions including predominantly water-, oil-, protein-containing, and dry

fractions (raisins, ketchup, apple juice, cottonseed meal, and cottonseed oil) stored at 

approximately -20oC. 

Samples of plant commodities from the crop field trial studies associated with this petition were 

stored frozen from harvest to analysis. The storage durations and conditions are presented under 

the respective field trials.

Adequate livestock commodity stability studies were previously submitted in conjunction with 

PP#7F7181 (DP#336941, L. Cheng, 2/25/2008; Monograph B.7) .Residues of chlorantraniliprole

and its metabolites IN-HXH44, IN-K9T00, IN-GAZ70 and IN-EQW78 in fortified (each at 0.10 

ppm) control samples of bovine liver, kidney, muscle, fat, and milk were shown to be stable 

during freezer storage for 12 months. A concurrent storage stability study was conducted with 

the crayfish study (see 5.3.6).

Conclusions

The storage stability data are adequate to support the crop field trials considered herein. All 

commodities were analyzed within the interval of demonstrated storage stability.

5.3 Residue Data
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5.3.1 Crop Field Trials (860.1500)

Green (Spring) Onion

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The Interregional Research Project Number 4 (IR-4) has submitted field trial data for 

chlorantraniliprole on green onion (fresh and dried). Five green onion trials were conducted in 

the NAFTA Growing Zones 1 (QC; 1 trial), 2 (MD; 1 trial), 5A (ON; 1 trial), and 10 (CA; 2 

trials.

Each trial consisted of one untreated plot and one treated plot. At each trial location, the treated 

plot received two foliar broadcast applications of a 1.67 lb ai/gal suspension concentrate (SC) 

formulation of chlorantraniliprole (Coragen® 20SC) at 0.098-0.105 lb ai/A/application for a total 

seasonal rate of 0.199-0.203 lb ai/A. Applications were made at a 3- to 4-day retreatment 

interval (RTI) using ground equipment in spray volumes of 22-45 gal/A with a nonionic 

surfactant (NIS) included in each spray mix. Samples of mature green onion (fresh) were 

harvested at a preharvest interval (PHI) of 1 day. Additional green onion samples from each site 

were dried for up to 10 days prior to collection. 

Samples were analyzed for residues of chlorantraniliprole using a high performance liquid 

chromatography method with LC/MS/MS based on DuPont-13294. The limit of quantitation 

(LOQ; determined as the lowest level of method validation, LLMV) was 0.01 ppm in/on green 

onion. The method was adequate for data collection based on acceptable method validation and 

concurrent recovery data. The fortification levels used in method validation and concurrent 

method recovery were adequate to bracket expected residue levels. Recoveries and residues in 

treated samples were not corrected for residues in controls.

Samples were stored frozen (-38 to -0.6 °C) from collection to analysis for 504-734 days (16.6-

24.1 months) for green onion. Samples were analyzed within 0-5 days of extraction. To support 

the sample storage intervals, a concurrent storage stability study was conducted with the field 

trial study. The data demonstrate that residues of chlorantraniliprole were stable in/on green 

onion stored frozen for up to 746 days (24.5 months). No 0-day data were provided. HED has 

concluded (see minutes of 6/19/13 Chemistry Science Advisory Council (ChemSAC) meeting) 

that recovery data from 0-day fortified samples are desirable for storage stability studies but are 

not mandatory

Following two foliar broadcast applications of the 1.67 lb ai/gal SC formulation of 

chlorantraniliprole at a total rate of 0.199-0.203 lb ai/A, residues of chlorantraniliprole (and per 

trial averages) in/on fresh green onion and dried green onion respectively, harvested at a 1-day

PHI, were 0.371-1.50 (0.406-1.49) ppm and 0.900-11.1 (1.00-10.8) ppm. The processing data 

indicate that residues of chlorantraniliprole concentrate in dried onions (processing factors of 

2.1-9.6x; median 3.4).

Dill Seed

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IR-4 has submitted field trial data for chlorantraniliprole on dill seed. Two dill seed trials were 
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conducted in Zones 2 (NC; 1 trial) and 11 (ID; 1 trial). 

Each trial consisted of one untreated plot and one treated plot. At each trial location, the treated 

plot received two foliar broadcast applications of a 1.67 lb ai/gal suspension concentrate (SC) 

formulation of chlorantraniliprole (Coragen® 20SC) at 0.098-0.105 lb ai/A/application for a total 

seasonal rate of 0.199-0.203 lb ai/A. Applications were made at a 3- to 4-day retreatment 

interval (RTI) using ground equipment in spray volumes of 22-45 gal/A with a nonionic 

surfactant (NIS) included in each spray mix. Samples of dill seed were harvested at a preharvest 

interval (PHI) of 1 day. 

Samples were analyzed for residues of chlorantraniliprole using LC/MS/MS based on DuPont13294. The limit of quantitation (LOQ; determined as the lowest level of method validation, 

LLMV) was 0.01 ppm in/on green onion and dill seed. The method was adequate for data 

collection based on acceptable method validation and concurrent recovery data. The fortification 

levels used in method validation and concurrent method recovery were adequate to bracket 

expected residue levels. Recoveries and residues in treated samples were not corrected for 

residues in controls.

Samples were stored frozen (-38 to -0.6 °C) from collection to analysis for 665-737 days (21.9-

24.2 months) for dill seed. Samples were analyzed within 0-5 days of extraction. To support the 

sample storage intervals, a concurrent storage stability study was conducted with the field trial 

study. The data demonstrate that residues of chlorantraniliprole were stable in/on dill seed, 

stored frozen for up to 797 days (26.2 months); no 0-day data were provided. HED has 

concluded (see minutes of 6/19/13 Chemistry Science Advisory Council (ChemSAC) meeting) 

that data for 0-day fortified samples are desirable for storage stability studies but are not 

mandatory

Following two foliar broadcast applications of the 1.67 lb ai/gal SC formulation of 

chlorantraniliprole at a total rate of 0.199-0.203 lb ai/A, residues of chlorantraniliprole (and per 

trial averages) in/on dill seed, respectively, harvested at a 1-day PHI, were 15.4-24.3 (17.0-19.8)

ppm. 

Peanut

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DuPont has submitted field trial data for chlorantraniliprole on peanuts. Six peanut trials were 

conducted in the United States in NAFTA Growing Zones 2 (GA, 3 trials), 3 (FL, 1 trial), 6 (TX, 

1 trial), and 8 (TX, 1 trial) during the 2011 growing season. The number and distribution of 

trials are adequate, per the recommendations of D381810 (S. Funk, 01/30/2011).

Each field trial included one control plot and one treated plot. At each site, the treated plot 

received two foliar broadcast applications of a 1.67 lb ai/gal (200 g ai/L) suspension concentrate 

(SC) formulation of chlorantraniliprole (DPX-E2Y45 20SC) at 0.099-0.102 lb ai/A/application 

(111-115 g ai/ha/application) for a total rate of 0.200-0.203 lb ai/A (224-228 g ai/ha). 

Applications were made with a 5- or 6-day retreatment interval (RTI), starting 6-7 days prior to 

harvest. Applications were made using ground equipment in a spray volume of 13-25 gal/A

(117-234 L/ha); an adjuvant was added to the spray mixture. Samples of peanuts were harvested 
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1 day after the last application of chlorantraniliprole. Peanut forage/hay was not collected, but 

alfalfa may be translated to cover peanut hay (S. Funk, D381810, 01/30.2011).

Samples of peanut nutmeats were analyzed for residues of chlorantraniliprole using LC/MS/MS

method. The limit of quantitation (LOQ), based on the lowest level of method validation 

(LLMV) was 0.01 ppm for chlorantraniliprole in/on peanut nutmeats. The method was adequate 

for data collection based on acceptable method validation and concurrent recoveries. The 

fortification levels used for concurrent recoveries were adequate to bracket expected residue 

levels.

Peanut samples were stored frozen at approximately 20 °C from collection to extraction for up 

to 3.3 months; samples were analyzed 0-1 days after extraction. Adequate storage stability

studies are available which demonstrate that residues of chlorantraniliprole are stable at 

approximately 20 C for at least 24 months in diverse crops, including water-, oil-, protein-, and 

starch-containing commodities as represented by fruits, a fruiting vegetable, a root crop, a nonoily grain, and an oilseed (DP# 336941, L. Cheng, 2/25/2008). These data are adequate to 

support the storage intervals and conditions of samples from the submitted field trial study.

Following two foliar broadcast applications of a 1.67 lb ai/gal SC formulation of 

chlorantraniliprole at a total rate of 0.20 lb ai/A, residues (and per trial averages) of 

chlorantraniliprole were <0.01 (<LOQ)-0.046 (<0.01-0.034) ppm in/on nutmeats harvested at a 

1-day PHI. 

Peanut hay was not collected or analyzed. It was previously decided that the results for alfalfa 

hay may be translated to peanut hay (D361791, D. Rate, 01/08/2010). Peanut and alfalfa have 

similar proposed use patterns except for the PHI; a 0-day PHI exists for alfalfa and a 1-day PHI

is proposed for peanuts. Residues on alfalfa hay ranged from 8.0 to 47 ppm from the foliar 

application of an SC formulation at a total application rate of 0.2 lb ai/acre (0.1 lb ai/acre X 2)

and a 0-day PHI. 

Rice

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DuPont has submitted field trial data for chlorantraniliprole on rice and crayfish. A total of 3 

crop field trials were conducted during the 2011 growing season in NAFTA Growing Zone 4 

(LA, 2 trials; MO, 1 trial). The number and distribution of trials meet the conditions set in 

D361791 (D. Rate, 01/08/2010). The trials were requested to confirm the tolerance of 0.15 ppm 

set for rice based on exaggerated (4X) field trials with chlorantraniliprole. 

Each field trial included one control plot and one treated plot. Seeds for each treated plot 

received one seed treatment of an undiluted 5.21 lb ai/gal flowable concentrate (FS) formulation 

of chlorantraniliprole (DPX-E2Y45-456) at a rate of 0.204 lb ai/100 lb seed. Based on seeding 

rates, the field application rate was 0.08 lb ai/A (90 g ai/ha). Seeds were planted 103-113 days 

after they had been treated. Mature rice was harvested 231-238 days after treatment, which was 

118-135 days after planting. 
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Samples of rice grain were analyzed for residues of chlorantraniliprole using LC/MS/MS 

methods, which was modified from Method DuPont-13294 (for rice grain). The limit of 

quantitation (LOQs), based on the lowest levels of method validation (LLMVs), was 0.010 ppm 

for chlorantraniliprole in/on rice grain. The method is adequate for data collection based on 

acceptable concurrent recoveries. The fortification levels used for concurrent recoveries were 

adequate to bracket expected residue levels.

Rice grain samples were stored frozen at approximately -20 °C from harvest to extraction for up 

to 3.2 months ; samples were analyzed 1-8 days after extraction. Adequate storage stability

studies are available which demonstrate that residues of chlorantraniliprole are stable at 

approximately -20 C for at least 24 months in diverse crops, including water-, oil-, protein-, and 

starch-containing commodities as represented by fruits, a fruiting vegetable, a root crop, a nonoily grain, and an oilseed (DP# 336941, L. Cheng, 2/25/2008). These data are adequate to 

support the storage intervals and conditions of samples from the submitted field trial study.

Following a single treatment of rice seed with a 5.21 lb ai/gal FS formulation of 

chlorantraniliprole at a rate of 0.204 lb ai/100 lb seed (equivalent to 0.08 lb ai/A), residues (and 

per trial averages) of chlorantraniliprole were <0.010-0.016 (<0.010-0.015) ppm in/on rice grain 

harvested 118-135 days after planting.

Strawberry

48930708.der

DuPont has submitted field trial data for chlorantraniliprole on strawberries. A total of 8 crop 

field trials were conducted during the 2011 growing season in NAFTA Growing Zones 1 (NY), 2 

(GA), 3 (FL), 5 (IA and MN, 1 trial each), 10 (CA, 2 trials), and 12 (BC). The number and 

distribution of trials meets the requirements of OCSPP 860.1500 and also fulfills the requests for 

confirmatory trials for strawberry (D361791, D. Rate, 01/08/2010). There is an existing 

tolerance of 1.0 pm for berry, low growing, subgroup 13-07G.

Each field trial included one control plot and one treated plot. The treated plot received two 

foliar broadcast applications of a 1.67 lb ai/gal (200 g ai/L) suspension concentrate (SC) 

formulation of chlorantraniliprole (Chlorantraniliprole 20SC) at 0.097-0.106 lb ai/A/application 

(109-119 g ai/ha/application) for a total rate of 0.19-0.21 lb ai/A (217-235 g ai/ha). Applications 

were made with a 6- to 7-day retreatment interval (RTI), beginning 7 or 8 days prior to harvest. 

Applications were made using ground equipment in a spray volume of 14-50 gal/A (131-466 

L/ha); an adjuvant was added to the spray mixture. Mature fruit was harvested 1 day after the 

last application of chlorantraniliprole.

Samples were analyzed for residues of chlorantraniliprole using a liquid chromatography/tandem 

mass spectrometry (LC/MS/MS) method, modified Method DuPont-13294. The limit of 

quantitation (LOQ), based on the lowest level of method validation (LLMV), was 0.010 ppm for 

chlorantraniliprole in/on strawberries. The method was adequate for data collection based on 

acceptable method validation and concurrent recoveries. The fortification levels used for 

concurrent recoveries were adequate to bracket expected residue levels.

Strawberries were stored frozen at approximately -20 °C from harvest to extraction for up to 6.8 
Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D407350

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months; samples were analyzed 1-4 days after extraction. Adequate storage stability studies are 

available which demonstrate that residues of chlorantraniliprole are stable at approximately -20 

C for at least 24 months in diverse crops, including water-, oil-, protein-, and starch-containing 

commodities as represented by fruits, a fruiting vegetable, a root crop, a non-oily grain, and an 

oilseed (DP# 336941, L. Cheng, 2/25/2008). These data are adequate to support the storage 

intervals and conditions of samples from the submitted field trial study.

Following two foliar broadcast applications of a 1.67 lb ai/gal SC formulation of 

chlorantraniliprole at a total rate of 0.2 lb ai/A, residues (and per trial averages) of 

chlorantraniliprole were 0.18-0.69 (0.18-0.68) ppm in/on strawberries harvested at a 1-day PHI.

Coffee

4930707.der

DuPont has submitted field trial data for chlorantraniliprole on coffee. One coffee trial was 

conducted in the United States in Growing Zone 13 (HI) during the 2011 growing season. The 

trial fulfills the requests for confirmatory data for coffee (D361791, D. Rate, 01/08/2010). A trial 

in region 13 was requested to meet the requirement of five trials. Also, the use of adjuvant was 

requested. There is an existing tolerance of 0.4 ppm for coffee green beans.

The field trial included one control plot and one treated plot. The treated plot received two foliar 

broadcast applications of a 35% (w/w) water-dispersible granule (WG) formulation of 

chlorantraniliprole (DPX-E2Y45-436) at 0.01 lb ai/A/application (111-112 g ai/ha/application) 

for a total rate of 0.2 lb ai/A (223 g ai/ha). Applications were made with a 14-day retreatment 

interval (RTI), starting 21 days prior to harvest. Applications were made using ground 

equipment in a spray volume of 57.1-57.4 gal/A (534-537 L/ha); an adjuvant was added to the 

spray mixture. Samples of mature coffee cherries were harvested 7 days after the last application 

of chlorantraniliprole, and coffee beans were collected 7 days later following the standard 

procedure for producing beans from cherries.

Samples were analyzed for residues of chlorantraniliprole using a LC/MS/MS method, modified 

Method DuPont-13294. The limit of quantitation (LOQ), based on the lowest level of method 

validation (LLMV), was 0.010 ppm for chlorantraniliprole in/on coffee beans. The method was 

adequate for data collection based on acceptable concurrent recoveries. The fortification levels 

used for concurrent recoveries were adequate to bracket expected residue levels.

Coffee green bean samples were stored frozen at approximately -20 °C from collection to 

extraction for 0.7 month; samples were analyzed 0-1 days after extraction. Adequate storage 

stability studies are available which demonstrate that residues of chlorantraniliprole are stable at 

approximately -20 C for at least 24 months in diverse crops, including water-, oil-, protein-, and 

starch-containing commodities as represented by fruits, a fruiting vegetable, a root crop, a nonoily grain, and an oilseed (DP# 336941, L. Cheng, 2/25/2008). These data are adequate to 

support the storage intervals and conditions of samples from the submitted field trial study.

Following two foliar broadcast applications of a 35% WG formulation of chlorantraniliprole at a 

total rate of 0.2 lb ai/A, residues of chlorantraniliprole were <0.010 ppm in/on coffee green beans 
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produced from coffee cherries harvested at a 7-day PHI. 

Cucumber

49076101.der

IR-4 has submitted greenhouse trial data for chlorantraniliprole on cucumber. Three greenhouse

trials were conducted in the United States during the 2008 growing season in the NAFTA 

Growing Zones 2 (MD; 1 trial), 3 (FL; 1 trial), and 9 (CO; 1 trial). The number of trials is in 

accordance with recommendations of ChemSAC for greenhouse use where a field use exists with 

the same use rate and PHI (ChemSAC Minutes, 09/24/2008).

Each trial consisted of one untreated plot and one treated plot. The cucumbers were grown in 

pots or in rockwool cubes. At each trial location, the treated plot received two foliar directed 

applications of a 1.67 lb ai/gal suspension concentrate (SC) formulation of chlorantraniliprole 

(Coragen® 20SC) at 0.098-0.122 lb ai/A/application for a total seasonal rate of 0.197-0.229 lb 

ai/A. Applications were made at a 3-day retreatment interval (RTI) using ground equipment in 

spray volumes of 35.7-50.2 gal/A with a nonionic surfactant (NIS) or a nonionic surfactant/ 

organosilicone surfactant (NIS/OSS) included in each spray mix. Samples of mature cucumbers 

were harvested at a preharvest interval (PHI) of 1 day. 

Samples were analyzed for residues of chlorantraniliprole using a LC/MS/MS method based on 

DuPont-13294. The limit of quantitation (LOQ; determined as the lowest level of method 

validation, LLMV) was 0.01 ppm in/on cucumbers. The method was adequate for data 

collection based on acceptable method validation and concurrent recovery data. The fortification 

levels used in method validation and concurrent method recovery were adequate to bracket 

expected residue levels. Recoveries and residues in treated samples were not corrected for 

residues in controls.

Samples were stored frozen (-37 to -0.2 °C) from collection to analysis for 525-562 days (17.3-

18.5 months). Samples were analyzed on the day of extraction. To support the sample storage 

intervals, a concurrent storage stability study was conducted with the greenhouse study. The 

data demonstrate that residues of chlorantraniliprole were stable in/on cucumbers stored frozen 

for up to 572 days (18.8 months); no 0-day data were provided. HED has concluded (see 

minutes of 6/19/13 Chemistry Science Advisory Council (ChemSAC) meeting) that 0-day

fortified samples are desirable for storage stability study but are not mandatory.

Following two foliar directed applications of the 1.67 lb ai/gal SC formulation of 

chlorantraniliprole at a total rate of 0.197-0.229 lb ai/A, residues of chlorantraniliprole (and per 

trial averages) in/on cucumbers harvested at a 1-day PHI were 0.0210-0.0738 (0.0257-0.0697)

ppm.

Tomato

49076102.der

IR-4 has submitted greenhouse trial data for chlorantraniliprole on tomato. Four greenhouse

trials were conducted in the United States during the 2007 growing season in the NAFTA

Growing Zones 2 (NJ and TN; 2 trials), 6 (TX; 1 trial), and 9 (CO; 1 trial). The number of trials 
Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D407350

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is in accordance with recommendations of ChemSAC for greenhouse use where a field use exists 

with the same use rate and PHI (ChemSAC Minutes, 09/24/2008).

Each trial consisted of one untreated plot and one treated plot. At each trial location, the treated 

plot received two foliar directed applications of a 1.67 lb ai/gal suspension concentrate (SC) 

formulation of chlorantraniliprole (Coragen® 20SC) at 0.099-0.106 lb ai/A/application for a total 

seasonal rate of 0.199-0.209 lb ai/A. Applications were made at a 4- to 6-day retreatment 

interval (RTI) using ground equipment in spray volumes of 50-94 gal/A. Adjuvants were not 

added to the spray mix. Samples of mature tomatoes were harvested at a preharvest interval 

(PHI) of 1 day. 

Samples were analyzed for residues of chlorantraniliprole using a LC/MS/MS method based on 

DuPont-13294. The limit of quantitation (LOQ; determined as the lowest level of method 

validation, LLMV) was 0.01 ppm in/on tomatoes. The method was adequate for data collection 

based on acceptable method validation and concurrent recovery data. The fortification levels 

used in method validation and concurrent method recovery were adequate to bracket expected 

residue levels. Recoveries and residues in treated samples were not corrected for residues in 

controls.

Samples were stored frozen (-37 to -2 °C) from collection to analysis for 77-229 days (2.5-7.5 

months). Samples were analyzed within 0-2 days of extraction. To support the sample storage 

intervals, a concurrent storage stability study was conducted with the greenhouse study. The 

data demonstrate that residues of chlorantraniliprole were stable in/on tomatoes stored frozen for 

up to 235 days (7.7 months); no 0-day data were provided. HED has concluded (see minutes of 

6/19/13 Chemistry Science Advisory Council (ChemSAC) meeting) that 0-day fortified samples 

are desirable for storage stability study but are not mandatory.

Following two foliar directed applications of the 1.67 lb ai/gal SC formulation of 

chlorantraniliprole at a total rate of 0.199-0.209 lb ai/A, residues of chlorantraniliprole (and per 

trial averages) in/on tomatoes harvested at a 1-day PHI were 0.0101-0.102 (0.0126-0.0963) ppm.

Cherry, Papaya, Lychee

49076103.der

Conditional registrations for the use of chlorantraniliprole on tropical fruit crops were 

established. A tolerance of 4.0 ppm for larger, slow-growing tropical fruits and a tolerance of 

2.0 ppm for smaller, fast-growing tropical fruits were established. The tolerances for tropical 

fruit are based on the translation of stone fruit data (D361791, D. Rate, 01/08/2010; ChemSAC 

Minutes 10/01/2008 and 11/17/2008). Residue decline studies were requested for cherry, 

lychee, and papaya. 

IR-4 has submitted residue decline field trial data for chlorantraniliprole on cherries, lychee, and 

papaya. Three field trials were conducted in the United States during the 2009 growing season. 

One cherry trial was conducted in NAFTA Growing Zone 11 (WA; 1 trial); one lychee trial was 

conducted in Zone 13 (FL; 1 trial); and one papaya trial was conducted in Zone 13 (HI; 1 trial).

Each trial consisted of one untreated plot and one treated plot. At each trial location, the treated 
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plot received two foliar directed applications of a 35% water dispersible granule (WG) 

formulation of chlorantraniliprole (Altacor®) at 0.099-0.105 lb ai/A/application for a total 

seasonal rate of 0.199-0.207 lb ai/A. Applications were made at a 9- to 10-day retreatment 

interval (RTI) using ground equipment in spray volumes of 76-198 gal/A with an nonionic 

surfactant (NIS) included in each spray mix. Samples of mature fruit were harvested at 

preharvest intervals (PHIs) of 1, 3, 6/7, 9/10, and 13/14/15 days. 

Samples were analyzed for residues of chlorantraniliprole using a LC/MS/MS method based on 

DuPont-13294. The limit of quantitation (LOQ; determined as the lowest level of method 

validation, LLMV) was 0.01 ppm in/on cherries, lychee, and papaya. The method was adequate 

for data collection based on acceptable method validation and concurrent recovery data. The 

fortification levels used in method validation and concurrent method recovery were adequate to 

bracket expected residue levels. Recoveries and residues in treated samples were not corrected 

for residues in controls.

Samples were stored frozen (-37 to -0.6 °C) from collection to analysis for 712-726 days (23.4-

23.9 months) for cherries, 713-725 days (23.5-23.8 months) for lychee, and 710-723 days (23.4-

23.8 months) for papaya. Samples were analyzed within 1-9 days of extraction. To support the 

sample storage intervals, a concurrent storage stability study was conducted with the field trial 

study. The data demonstrate that residues of chlorantraniliprole were stable in/on cherries stored 

frozen for up to 802 days (26.4 months); no 0-day data were provided. HED has concluded (see 

minutes of 6/19/13 Chemistry Science Advisory Council (ChemSAC) meeting) that 0-day

recovery data for fortified samples are desirable for storage stability studies but are not 

mandatory.

Following two foliar directed applications of the 35% WG formulation of chlorantraniliprole at a 

total rate of 0.199 lb ai/A, residues of chlorantraniliprole (and per trial averages) in/on cherries 

harvested at 1-, 3-, 6-, 10-, and 15-day PHIs, respectively, were: 0.151-0.192 (0.171), 0.135-

0.162 (0.148), 0.105-0.120 (0.112), 0.132-0.151 (0.141), and 0.0994-0.129 (0.114) ppm. 

Following two foliar directed applications of the 35% WG formulation of chlorantraniliprole at a 

total rate of 0.200 lb ai/A, residues of chlorantraniliprole (and per trial averages) in/on lychee 

harvested at 1-, 3-, 6-, 9-, and 13-day PHIs, respectively, were: 0.402-0.500 (0.451), 0.306-0.442 

(0.374), 0.363-0.386 (0.374), 0.239-0.313 (0.276), and 0.308-0.337 (0.322) ppm.

Following two foliar directed applications of the 35% WG formulation of chlorantraniliprole at a 

total rate of 0.207 lb ai/A, residues of chlorantraniliprole (and per trial averages) in/on papaya 

harvested at 1-, 3-, 7-, 10-, and 14-day PHIs, respectively, were: 0.284-0.292 (0.288), 0.204-

0.224 (0.214), 0.196-0.211 (0.203), 0.164-0.196 (0.180), and 0.137-0.142 (0.139) ppm.

The half-lives were calculated based on the assumption of first order kinetics and a slope m 

determined by least squares straight line fit of ln average concentration versus time (days); t 1/2 = 

ln 2/m for all sampling intervals. The half-lives ranged from 14 to 32 days. These results 

confirm that very small fruit (cherry) and tropical fruits have approximately the same half-lives 

as stone fruits (median 33, minimum 19 days) and pome fruits (median 23, minimum 11 days)

(D361791, D. Rate, 01/08/2010; ChemSAC Minutes 10/01/2008 and 11/17/2008) . This 
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validates the previous decision to translate the stone fruit tolerance to tropical fruits and to 

reduce the PHI for some tropical fruits from 10 days to 1 day with a 2x correction applied to the 

stone fruit tolerance. The half-lives show that residues will not exceed a doubling (2x) with a 

reduction from 10 days to 1 day in the PHI. 

Therefore, the proposal to reduce the PHI for papaya and passionfruit from 10 days to 1 day with 

an increase in the tolerances from 2 ppm to 4 ppm is acceptable. 

Table 5.3.1.1 Residue Data from Cherry, Lychee, and Papaya Field Trials with Chlorantraniliprole.

Trial ID

(City, State, Province; Year)

Zone Crop; 

Variety

Commodity Total Rate

(lb ai/A)

PHI

(days)

Residues Chlorantraniliprole 

(ppm) [Average]1

Cherry Trials

Prosser, WA; 2009 (WA03) 11 Cherry; Sweetheart Fruit 0.199 1 0.151, 0.192 [0.171]

3 0.135, 0.162 [0.148]

6 0.105, 0.120 [0.112]

10 0.151, 0.132 [0.141]

15 0.129, 0.0994 [0.114]

Half life131 days

Lychee Trials

Homestead, FL; 2009 (FL69) 13 Lychee; Brewster Fruit 0.200 1 0.402, 0.500 [0.451]

3 0.306, 0.442 [0.374]

6 0.386, 0.363 [0.374]

9 0.313, 0.239 [0.276]

13 0.337, 0.308 [0.322]

Half life132 days

Papaya Trials

Hilo, HI; 2009 (HI01) 13 Papaya; Rainbow Fruit 0.207 1 0.292, 0.284 [0.288]

3 0.204, 0.224 [0.214]

7 0.211, 0.196 [0.203]

10 0.196, 0.164 [0.180]

14 0.137, 0.142 [0.139]

Half life114 days

1 Assumes first order kinetics and a slope m determined by least squares straight line fit of ln average concentration 

versus time (days); t 1/2 = ln 2/m.

Table 5.3.1.2. Summary of Residues from Field Trials with Chlorantraniliprole

Crop 

Matrix Analyte

Applic. 

Rate

(lb ai/acre)

PHI 

(days) n

*

Residues (ppm)

Min.† Max.† LAFT* HAFT* Median* Mean*SD*

Peanut Proposed Use = 0.20 lb ai/acre total application rate. 1 day PHI

Nutmeat

Chlorantraniliprole

0.20 1 6 <0.01 0046 <0.01 0.034 0.01 0.014 0.010

Rice Proposed Use = 0.08 lb ai/acre total application rate, at-plant application
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Grain

Chlorantraniliprole

0.08 125-

135 3 <0.010 0.016 <0.010 0.015 0.012 0.012 0.02

Berry, low growing, subgroup 13-07G. Proposed Use = 0.20 lb ai/acre total application rate. 1 day PHI

Strawberry

fruit

Chlorantraniliprole

0.2 1 8 0.18 0.69 0.18 0.68 0.23 0.30 0.17

Coffee. Proposed Use = 0.20 lb ai/acre total application rate. 7 day PHI

Coffee 

green bean

Chlorantraniliprole

0.2 7 1 <0.010 <0.010 <0.010 <0.010 0.01 0.01 NA

Cucumber. Proposed Use = =0.20 lb ai/acre total application rate in greenhouse. 1 day PHI

Cucumber

fruit

Chlorantraniliprole

0.20- 0.23 1 3 0.0210 0.0738 0.0257 0.0697 0.0296 0.0417 0.0244

Tomato. Proposed Use =0.20 lb ai/acre total application rate in greenhouse. 1 day PHI

Tomato 

fruit

Chlorantraniliprole

0.20-0.21 1 4 0.0101 0.102 0.0126 0.0963 0.0314 0.0429 0.0378

Onion, green, subgroup 3-07B. Proposed use = 0.20 lb ai/acre total application rate per crop. 1 day PHI

Green 

onion

Chlorantraniliprole

0.20 1 5 0.371 1.50 0.406 1.49 0.717 0.811 0.406

Green 

onion, dry

Chlorantraniliprole

0.20 1 5

0.900 11.1 1.00 10.8 2.66 4.44 4.11

Dill seed. Proposed Use = 

Dill seed

Chlorantraniliprole

0.20 1 2 15.4 24.3 17.0 19.8 18.4 18.4 N/A

† Values based on total number of samples.

* Values based on per-trial averages. LAFT = Lowest Average Field Trial, HAFT = Highest Average Field Trial, SD = Standard 

Deviation. For computation of the LAFT, HAFT, median, mean, and standard deviation, values < LOQ are assumed to be at the 

LOQ.

Conclusions.

The greenhouse tomato trials are adequate to cover the use on fruiting vegetables in greenhouses, 

per the decision of ChemSAC (Minutes of the ChemSAC Meeting, 09/29/2010). The 

greenhouse cucumber trials are adequate to cover the use on cucumber grown in greenhouses. In 

both instances, the existing tolerances will encompass the expanded use (See 6.0).

The strawberry field trials were conducted according to the label for crop subgroup 13-07G. The 

existing tolerance for this subgroup will encompass the use on strawberry (See 6.0). The data 

fulfill the condition or registration requirement for strawberry (D361791, D. Rate, 01/08/2010).

The peanut field trials provide adequate data to support a tolerance on peanut nutmeat. The 

number and distribution of trials are adequate, per the recommendations of D381810 (S. Funk, 

01/30/2011). Alfalfa hay results may be translated to peanut nutmeat.

The rice seed treatment trials are adequate to confirm the existing tolerance and fulfill a 

condition of registration requirement (D316791, D. Rate, 01/08/2010). See 6.0.
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The single residue decline studies on cherry, papaya, and lychee completes the condition of 

registration data requirement for decline data on (tropical) fruits of small and large size 

(D316791, D. Rate, 01/08/2010). The request to decrease the PHI for papaya and passionfruit 

from 10 days to 1 day with increases in the tolerances from 2 ppm to 4 ppm is acceptable.

5.3.2 Field Rotational Crops (860.1900)

DP#404708, S. Funk, 09/10/2013 (PP#2E8064)

DP#382293, S. Funk, 02/28/2011 (PP#0F7763)

DP#353542, L. Cheng, 6/18/2008 (PP#7F7181)

DP#336941, L. Cheng, 2/25/2008 (PP#7F7181)

Minutes of the April 9, 2008 Meeting of the HED Chemistry SAC (ChemSAC min_388.4-9-08)

DP#361791, D. Rate, 01/08/2010 (PP#9F7513)

DP#384485, D. Rate, 12/01/2010 

Chlorantraniliprole is the major residue in all rotational crop commodities studied. No new field 

rotational crop data were presented

Acceptable studies pertaining to limited field accumulation in rotational crops were reviewed in 

PP#7F7181 (DP#353542, L. Cheng, 6/18/2008). HED concluded that these data are adequate for 

estimation of the magnitude of residues of chlorantraniliprole in root, leafy, and cereal grain 

crops when grown rotationally in fields previously treated with chlorantraniliprole at total 

seasonal rates of 0.9-2.7x. Generally, residues at or above the LOQ (0.010 ppm) may occur on 

rotated leafy crops and on the tops of root vegetables at plantback intervals of 30-130 days, 

ranging between 0.01 and 0.2 ppm, whereas residues on grain and root vegetables are anticipated 

to be below the LOQ. Chlorantraniliprole residues (>0.01 ppm) are also possible in livestock 

feedstuffs of rotated grain crops (forage, straw, hay), ranging from 0.02 to 0.2 ppm for plantback 

intervals (PBIs) ranging from 30-240 days. These data suggested that rotational crop tolerances 

are required, and that the petitioner needs to conduct extensive field rotational crop trials. HED 

previously concluded that until the requested data are submitted, a restriction should be imposed 

on the proposed labels to prohibit the rotation to any crop not on the label (DP#336941, L. 

Cheng, 2/25/2008).

The petitioner subsequently submitted proposals and justification requesting no rotational crop 

restrictions for chlorantraniliprole and for the establishment of tolerances for inadvertent residues 

for a number of crops. The submission was brought to HED’s ChemSAC for discussion on April 

9, 2008. Based on the available data, the ChemSAC determined that a 30-day plant-back interval 

is appropriate for all crops requested (bulb vegetables, peanuts, sugar cane, asparagus, okra, 

strawberry, crop groups 6, 15, 16, 17, 18) except Crop Groups 1 and 2, for which a 0-day PBI is 

allowable. 

Time-limited tolerances, with expiration date of 4/10/14, were previously established for indirect 

or inadvertent residues of chlorantraniliprole in/on: cereal grain forage, fodder and straw (Crop 

Group 16) at 0.20 ppm; leek at 0.20 ppm; green onion at 0.20 ppm; Welsh onion at 0.20 ppm; 

peanut hay at 0.20 ppm; and shallot fresh leaves at 0.20 ppm. These have been recommended for 

removal upon relevant primary crop (crop group) tolerances.
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Subsequently the addition of the following oilseed rotational crops with a reduction of the PBI 

from 12 months to 30 days was made (D384485, D. Rate, 12/01/2010): borage, calendula, castor 

oil plant, Chinese tallowtree, cuphea, echium euphorbia, evening primrose, flax, gold of 

pleasure, meadowfoam, niger seed, safflower, stokes aster, sunflower, sweet rocket, and 

veronica. The 30-day PBI was subsequently extrapolated to all rotated oilseeds, based on rotated 

cereal grain and soybean seed data (D397571, S.Funk, 05/01/2012). 

Conclusions. 

Adequate field rotational crop studies have been conducted previously to support appropriate 

plant-back intervals for those crops with no primary uses. Additional data are not required.

5.3.3 Processed Food and Feed (860.1520)

No new processing studies were provided. Peanuts in the only commodity addressed herein for 

which the required processing study has not been conducted/reviewed . DuPont previously

requested a waiver from the peanut processing study based on a translation of the results of the 

cottonseed processing study (D382293, S. Funk, 02/30/2011). In the cottonseed processing 

study (MRID 46979734), delinted cottonseed was mechanically cracked and the hulls separated 

from the kernels. The kernels were dried to 12% moisture content, heated, flaked, and 

expanded/extruded under steam to collets. The collets are extracted with solvent (hexane). The 

miscella (crude oil and hexane) is separated, the crude oil is heated to remove residual hexane, 

and the oil is refined by alkali treatment.

A very similar commercial process is used with peanuts, although as a first step peanuts may be 

subjected to mechanical pressure to remove some oil. The resulting press cake is extracted with 

hexane, and the oil fractions are combined and purified with alkali treatment.

In the cotton processing study, average residues of chlorantraniliprole were 0.016 ppm in cotton 

seed harvested 21 days after treatment with the 35WG at a total rate of 0.40 lb ai/A. Average 

residues after processing were 0.004, 0.012 and 0.033 ppm in refined oil, meal and hulls, 

respectively. The results of the cotton processing study show that chlorantraniliprole upon 

processing does not concentrate in refined oil (0.25x) or meal (0.75x) but concentrates in hulls 

(2.1x) (D336941, L Cheng, 02/25/2008).

The oil content of peanuts is 45 – 52% (Agricultural Marketing Resource Center, Iowa State 

University). The oil content of cottonseed is 18 – 26% (Table 4, OECD Guidance Document on 

Magnitude of the Pesticide Residues in Processed Commodities, ENV/JM/MONO(2008)23, 

07/29/2008). As the commercial processing procedures for cottonseed and peanut are similar 

and peanut yields more oil than cottonseed for a given weight of commodity, the cottonseed 

processing results may be translated to peanut. Concentration of chlorantraniliprole will not 

occur in peanut oil (0.25x) or peanut meal (0.75x). 

Conclusions:

The cottonseed processing study may be translated to peanuts. Concentration of 

chlorantraniliprole from peanut to oil is not anticipated. The concentration/reduction factors are 
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0.25x for peanut oil and 0.75x for peanut meal.

5.3.4 Meat, Milk, Poultry and Eggs (860.1480)

An acceptable ruminant feeding study (MRID 46895504) was previously submitted in 

connection with PP#7F7181 (DP#336941, L. Cheng, 2/25/2008). An acceptable poultry feeding 

study was previously submitted (D404708, S. Funk, 09/10/2013) No new feeding study data 

were submitted.

5.3.4.1 Dietary Burden

Peanut meal and peanut hay are the only new feed item associated with the current submissions. 

Peanut meal is a protein concentrate fed to dairy cattle (10%), poultry (25%), and swine (15%). 

Peanut hay is a roughage fed only to dairy cattle (15%). The dietary burdens (D404708, S.Funk, 

09/10/2013) will not change as a result of these new feeds. Other feed items already considered 

contribute more to the total dietary burden.

 

5.3.4.2 Estimated Secondary Residues in Livestock 

The estimated secondary residue in livestock remain unchanged from the latest calculation 

(D404708, S.Funk, 09/10/2013).

Conclusions:

The dietary burdens of poultry, swine, and ruminants remain unchanged. The existing tolerances 

for meat, milk, poultry, and eggs are adequate.

5.3.5. Food Handling (860.1460)

There are no food handling uses related to the current submissions.

5.3.6 Water, Fish, and Irrigated Crops (860.1400)

48930701.der

Crayfish

DuPont has submitted field trial data for chlorantraniliprole on rice and crayfish. A total of 3 

crop field trials were conducted during the 2011 growing season in North Atlantic Free Trade 

Agreement (NAFTA) Growing Zone 4 (LA, 2 trials; MO, 1 trial). A previous request to waive 

the study was denied (D361791, D. Rate, 01/08/20100.

Each field trial included one control plot and one treated plot. Seeds for each treated plot 

received one seed treatment of an undiluted 5.21 lb ai/gal flowable concentrate (FS) formulation 

of chlorantraniliprole (DPX-E2Y45-456) at a rate of 0.204 lb ai/100 lb seed. Based on seeding 

rates, the field application rate was 0.08 lb ai/A (90 g ai/ha). Seeds were planted 103-113 days 

after they had been treated. Mature rice was harvested 231-238 days after treatment, which was 

118-135 days after planting. Crayfish were collected from the plots, when possible, at the 
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following intervals after planting rice: 51-52 days (early first season), 76-77 days (mid first 

season), 103 days (late first season), and 279 or 318 days (normal harvest).

Samples of crayfish were analyzed for residues of chlorantraniliprole and its metabolite INECD73 (in crayfish only) a using a LC/MS/MS method, which was modified from Method 

DuPont-24137 (for crayfish). The limits of quantitation (LOQs), based on the lowest levels of 

method validation (LLMVs), were 0.010 ppm for chlorantraniliprole in crayfish and 0.010 ppm 

for IN-ECD73 in crayfish. The fortification levels used for concurrent recoveries were adequate 

to bracket expected residue levels.

Crayfish samples were stored frozen at approximately -20 °C from harvest to extraction for up to 

9.9 months; samples were analyzed 1-8 days after extraction. Storage stability data generated 

concurrently with the field trial study demonstrate that residues of chlorantraniliprole and INECD73 were stable in/on crayfish for up to 10 months of frozen storage. These data are 

adequate to support the storage intervals and conditions of samples from the submitted trial 

study.

Following a single treatment of rice seed with a 5.21 lb ai/gal FS formulation of 

chlorantraniliprole at a rate of 0.204 lb ai/100 lb seed (equivalent to 0.08 lb ai/A), residues (and 

per trial averages) of chlorantraniliprole and IN-ECD73 were all below the LOQ (<0.010 ppm 

each) in/on all samples of crayfish collected 51-52, 76-87, 103-122, and 279-318 days after rice 

was planted. 

Conclusions

The rice seed treatment reflects the proposed maximum application rate. Adequate concurrent 

storage stability data were presented to support the residue data, and an adequate data collection 

analytical method was utilized. The lack of residues (<0.01 ppm chlorantraniliprole) in crayfish 

at sampling intervals of 51 to 318 days after rice planting shows no bioaccumulation of 

chorantraniliprole. The existing tolerance of 8.0 ppm may be reduced to 0.01 ppm.

6.0 Tolerance Derivation

Tolerance estimates for rice grain (3 trials), peanut (6 trials), strawberry (8 trials), coffee green 

beans (5 trials), greenhouse cucumber (5 trials), greenhouse tomato (4 trials), and green onions 

(5 trials) were made by use of the OECD tolerance calculation procedures. The statistical goal of 

the tolerance calculation procedures is to produce an MRL proposal in the region of the 95th

percentile of the underlying residues distribution. The existing tolerances for rice grain, 

strawberry (berry low growing subgroup 13-07H), coffee green beans, cucurbit vegetables group 

9, and fruiting vegetables group 8-10 were confirmed, that is, the tolerance estimates obtained 

from the new field trial data sets were the same as or lower than the existing tolerances.

The tolerance estimate for peanut nutmeats was 0.06 ppm. No analyses were conducted for 

peanut hay, but it was previously decided (D361791, D. Rate, 01/08/2010). that alfalfa hay may

be translated to peanut hay. The animal feed nongrass group 18 (including alfalfa) hay tolerance 

is 90 ppm.
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The green onion tolerance estimate of 3.0 ppm may be used for the onion, green, subgroup 3-

07B.

The conversion of green onions to dried onions has an median processing factor of 3.4. That 

factor applied to the green onion highest field trial residue, 1.49 ppm, yields a tolerance estimate 

of 5 ppm for dried onions. The dried onion may be used as a surrogate for dried chive, a 

representative commodity of crop subgroup 19A. The existing tolerance for the herb subgroup 

19A is 90 ppm, and is based on the extrapolation of alfalfa hay to dried basil. The 90 ppm will 

be retained, as it represents possible residue levels in dried basil, the other representative 

commodity for subgroup 19A.

Two dill seed trials were conducted. Where only two trials are conducted, the OECD calculation 

spreadsheet is not applicable. The residue estimate is taken as 5 X mean, or 5 X 19.4. The 

tolerance estimate for the spices subgroup 19B is 90 ppm. This replaces the existing estimate of 

14.0 ppm (D361791, D. Rate, 01/08/2010). Note that the registrant petitioned for 40 ppm.

The crayfish study (n = 3 trials) included samples taken from 50 – 318 days after planting of 

treated rice seeds. All samples of crayfish contained no residues at the LOQ of 0.01 ppm. The

existing tolerance of 8 ppm was based on the use of a fish bioconcentration study and the 

estimated residues in water, sediment, and rice straw. Therefore, the tolerance may be lowered 

to 0.01 ppm.

The tolerances for papaya and passion fruit will be increased from 2 ppm to 4 ppm. This reflects 

a requested decrease in the PHI from 10 days to 1 day. The residue decline study with cherry, 

leechee, and papaya shows that the half-life is in excess of 10 days and that, therefore, a doubling 

of the tolerance will be adequate (D361791, D. Rate, 01/08/2010). 
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Appendix A. International Residue Limits Table

Table A1. Summary of US and International Tolerances and Maximum Residue Limits of 

Chlorantraniliprole

Residue Definition

US Canada Mexicob Codex

40CFR§180.628. For plant and animal 

commodities: chlorantraniliprole, 3-bromo-N-[4-

chloro-2-methyl-6-

[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-

pyridinyl)-1H-pyrazole-5-carboxamide

3-bromo- N -[4-

chloro-2-methyl-6-

[(methylamino)carbo

nyl]phenyl]-1-(3-

chloro-2-pyridinyl)-

1H-pyrazole-5-

carboxamide.

Chlorantraniliprole

(fat soluble)

Commoditya Tolerance (ppm) /Maximum Residue Limit (mg/kg)

US Canada Mexicob Codex

Crayfish 0.01 None

Fruit, pome, group 11-10 1.2

0.4 (listed as 

individual 

commodities: apple, 

etc)

0.4 

Fruit, stone, group 12-12, except 

cherry, Chickasaw plum, and 

damson plum

4.0

2.5 (listed as 

individual 

commodities: peach, 

etc)

1

Nut, tree, group 14-12 0.02

0.02

(listed as individual 

commodities: 

almond, chestnut, 

etc)

0.02

Papaya 4.0 None None

Passionfruit 4.0 None None

Peanut, nutmeat 0.06 0.06 (pending) None

Peanut, hay 90 None None

Onion, green, subgroup 3-07B 3.0

3.0 (pending)(listed 

as individual 

commodities: green 

onion, etc)

None

Spice subgroup 19B 90 None None

Completed: 10/30/2013

a Includes only commodities of interest for this action. Tolerance values should be the HED recommendations and 

not those proposed by the applicant.

b Mexico adopts US tolerances and/or Codex MRLs for its export purposes.
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Appendix B. OECD MRL Calculation Procedure Inputs/Outputs

Tree Nuts

Almond

Almond

Chlorantraniliprole

US

GAP

Total number of data (n) 6

Percentage of censored data 100%

Number of non-censored data 0

Lowest residue 0.010

Highest residue 0.010

Median residue 0.010

Mean 0.010

Standard deviation (SD) 0.000

Correction factor for censoring (CF) 0.333

Proposed MRL estimate

- Highest residue 0.010

- Mean + 4 SD 0.010

- CF x 3 Mean 0.010

Unrounded MRL 0.010

Rounded MRL 0.01

High uncertainty of MRL estimate.

[Small dataset and high level of censoring]

‘

Residues (mg/kg) n

< 0.01 6

Pecan

Chlorantraniliprole

pecan

US

GAP

Total number of data (n) 6

Percentage of censored data 67%

Number of non-censored data 2

Lowest residue 0.010

Highest residue 0.015
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Median residue 0.010

Mean 0.012

Standard deviation (SD) 0.002

Correction factor for censoring (CF) 0.556

Proposed MRL estimate

- Highest residue 0.015

- Mean + 4 SD 0.021

- CF x 3 Mean 0.019

Unrounded MRL 0.021

Rounded MRL 0.02

High uncertainty of MRL estimate.

[Small dataset and high level of censoring]

Residues (mg/kg) n

< 0.01 4

0.014 1

0.015 1

Rice

Three trials were conducted to confirm a 0.15 ppm tolerance on grain set from exaggerated (4X) 

trials. The existing tolerance for rice grain is 0.15 ppm. The estimate from the present three 

trials is 0.04 ppm. The tolerance is confirmed as adequate.

chlorantraniliprole

rice

USA

seed treatment

Total number of data (n) 3

Percentage of censored data 0%

Number of non-censored data 3

Lowest residue 0.010

Highest residue 0.015

Median residue 0.012

Mean 0.012

Standard deviation (SD) 0.003

Correction factor for censoring (CF) 1.000

Proposed MRL estimate
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- Highest residue 0.015

- Mean + 4 SD 0.022

- CF x 3 Mean 0.037

Unrounded MRL 0.037

Rounded MRL 0.04

High uncertainty of MRL estimate.

[Small dataset]

Residues (mg/kg) n

0.01 1

0.012 1

0.015 1
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Peanut

Chlorantraniliprole

Peanut

USA

2X0.1 lb ai/A, 1 d PHI

Total number of data (n) 6

Percentage of censored data 67%

Number of non-censored data 2

Lowest residue 0.010

Highest residue 0.034

Median residue 0.010

Mean 0.014

Standard deviation (SD) 0.010

Correction factor for censoring (CF) 0.556

Proposed MRL estimate

- Highest residue 0.034

- Mean + 4 SD 0.053

- CF x 3 Mean 0.024

Unrounded MRL 0.053

Rounded MRL 0.06

High uncertainty of MRL estimate.

[Small dataset and high level of censoring]

Residues (mg/kg) n

< 0.01 4

0.012 1

0.034 1
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Strawberry (Berry, low growing, subgroup 13-07G)

Chlorantraniliprole

Strawberry

USA

2X-0.1 lb ai/A, 1 d PHI

Total number of data (n) 8

Percentage of censored data 0%

Number of non-censored data 8

Lowest residue 0.180

Highest residue 0.680

Median residue 0.235

Mean 0.298

Standard deviation (SD) 0.169

Correction factor for censoring (CF) 1.000

Proposed MRL estimate

- Highest residue 0.680

- Mean + 4 SD 0.972

- CF x 3 Mean 0.893

Unrounded MRL 0.972

Rounded MRL 1

Residues (mg/kg) n

0.18 1

0.2 1

0.21 1

0.23 1

0.24 2

0.4 1

0.68 1
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Coffee Green Bean

The existing tolerance for coffee green beans is 0.4 ppm. An addition trial was conducted to 

assess the effect of adjuvant and to fulfill the requirement for five trials. The combined data 

yields a tolerance estimate of 0.4 ppm. This confirms the existing tolerance.

The initial 4 trials were conducted at 0.7x the label rate (MRID 47588222). The residues were 

corrected to 1x by the use of proportionality.

Chlorantraniliprole

Coffee

US

0.2 lb ai/acre, 7 d PHI

Total number of data (n) 5

Percentage of censored data 20%

Number of non-censored data 4

Lowest residue 0.010

Highest residue 0.160

Median residue 0.140

Mean 0.122

Standard deviation (SD) 0.063

Correction factor for censoring (CF) 0.867

Proposed MRL estimate

- Highest residue 0.160

- Mean + 4 SD 0.376

- CF x 3 Mean 0.317

Unrounded MRL 0.376

Rounded MRL 0.4

High uncertainty of MRL estimate.

[Small dataset]

Residues (mg/kg) n

< 0.01 1

0.141 2

0.161 2

1 Adjusted to 1x application rate.
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Cucumber (Greenhouse)

The tolerance estimate for cucumbers from greenhouse use is 0.15 ppm. The existing tolerance 

for vegetable, cucurbit, group 9 is 0.5 ppm, which is within 5X of the estimate for greenhouse 

use on cucumber.

Chlorantraniliprole

Cucumber (greenhouse)

USA

0.2 lb ai/A, 1 d PHI

Total number of data (n) 3

Percentage of censored data 0%

Number of non-censored data 3

Lowest residue 0.026

Highest residue 0.070

Median residue 0.030

Mean 0.042

Standard deviation (SD) 0.024

Correction factor for censoring (CF) 1.000

Proposed MRL estimate

- Highest residue 0.070

- Mean + 4 SD 0.139

- CF x 3 Mean 0.125

Unrounded MRL 0.139

Rounded MRL 0.15

High uncertainty of MRL estimate.

[Small dataset]

Residues (mg/kg) n

0.0257 1

0.0296 1

0.0697 1
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Tomato (Greenhouse)

The tolerance estimate for tomato from greenhouse use is 0.20 ppm. The existing tolerance for 

vegetable, fruiting, group 8-10 is 1.4 ppm. The existing tolerance for the crop group is adequate 

for tomatoes from greenhouse use. While the existing tolerance is >5X from the new estimate, 

the existing tolerance also reflects the use of adjuvants. 

Chlorantraniliprole

Tomato (Greenhouse)

USA

0.2 lb ai/A, 1 day PHI

Total number of data (n) 4

Percentage of censored data 0%

Number of non-censored data 4

Lowest residue 0.013

Highest residue 0.096

Median residue 0.031

Mean 0.043

Standard deviation (SD) 0.038

Correction factor for censoring (CF) 1.000

Proposed MRL estimate

- Highest residue 0.096

- Mean + 4 SD 0.194

- CF x 3 Mean 0.129

Unrounded MRL 0.194

Rounded MRL 0.2

High uncertainty of MRL estimate.

[Small dataset]

Residues (mg/kg) n

0.0126 1

0.0203 1

0.0424 1

0.0963 1
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Green Onion

Chlorantraniliprole

Green Onion

USA

2X0.1 la ai/A, 1 d PHI

Total number of data (n) 5

Percentage of censored data 0%

Number of non-censored data 5

Lowest residue 0.406

Highest residue 1.490

Median residue 0.717

Mean 0.811

Standard deviation (SD) 0.406

Correction factor for censoring (CF) 1.000

Proposed MRL estimate

- Highest residue 1.490

- Mean + 4 SD 2.435

- CF x 3 Mean 2.432

Unrounded MRL 2.435

Rounded MRL 3

High uncertainty of MRL estimate.

[Small dataset]

Residues (mg/kg) n

0.406 1

0.653 1

0.717 1

0.787 1

1.49 1

Dried Green Onion

Dried green onion will be used as a representative of chives (D361791, D. Rate, 01/08/2010), 

which in turn is a representative commodity for herb subgroup 19A. Five trials were conducted 

with residues of 6.25, 1.00, 2.66, 10.8, and 1.48 ppm, which provided processing factors of 9.6x, 

2.5x, 3.4x, 7.2x, and 2.1x. The median processing factor, 3.4x, applied to the green onion 

highest average field trial (HAFT), 1.49 ppm, yields a tolerance estimate of 5 ppm. This 

contrasts to the existing tolerance of 90 ppm for dried herbs subgroup 19A. The existing 
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tolerance will be retained, based on the previous translations and the lack of field trial data for 

the other representative commodity, basil (fresh and dried). Note that the registrant has not 

requested a change to this tolerance.

Dill Seed

Dill seed is one of the two representative commodities for the spices subgroup 19B. The other is 

black pepper. Two trials were conducted, and therefore the OECD MRL calculation spreadsheet 

cannot be used. In such situations, the tolerance estimate is taken as 5 X Mean, or 5 X 19.4 = 92 

ppm. The tolerance estimate for the spices subgroup 19B is 90 ppm. This replaces the existing 

estimate of 14.0 ppm (D361791, D. Rate, 01/08/2010).