Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 1 of 44 **UNITED STA**

**TES ENVIRONMENTA L PROTECTION A** **GENCY** WA SHINGTON, D.C. 20460 **OFFICE OF CHEMICAL SAFETY AND**

**POLLUTION PREVENTION MEMORANDUM**  Date: November 12, 2013 Subject: **Chlorantraniliprole** . Petition for the Establishment of Permanent Tolerances and

Registration for Use on Peanuts and on Green Onion, Addition of Use on Greenhouse Tomato and Greenhouse Pepper and Greenhouse Cucumber, Crop Group Conversions for Stone Fruit and Tree Nuts, and La bel Amendment to Shorten the PHI for Passionfruit, Papaya, and May haw . Condition of Registration Data for Rice, Crayfish, Coffee, Strawberry, and Livetock Anal ytical Methods. Summary of Analy tical Chemistry

and Residue Data. PC Code: 090100 DP Barcode: D 407350; D 416 101 Decision No.: 476038; 477960; 477964; 477967; 477972; 477962 ; 477952; 477 965; 477970; 477963; 477954; 477966; 477971; 417413 Registration No. : 352 - 728; 352 - 729; 352 - 730; 352 - 820; 352 - 841; 352 - 838; 352 - 844 Petition No s .: 3 E8170 ; 3F8158 Regulatory Action: Section 3 Registration Risk Assessment T ype: NA Case No.: N/A T XR No.: NA CAS No.: 500008 - 45 - 7 MRID No.: See Below 40 CFR §180.628 From: Steve Funk, Senior Chemist

Risk Assessment Branch III ( RAB III ) Health Effects Division ( HED; 7509P) Through: Christine Olinger, Branch Chief

Risk Assessment Branch III ( RAB III ) Health Effect Division ( HED ; 7509P ) To: Venus Eagle/Jennifer Urbanski, RM 01

Registration Division ( RD; Mail Stop 7505P ) And Barbara Madden/Laura Nollen, MR 05 Registration Division (RD; Mail Stop 7505P)Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 2 of 44 O C S PP 860 Series Guideline MRID Number Title 860.1340 48930702 Vogl, E.; Stry, J. (2012) Analytical Method for the Determination of Chlorantraniliprole and IN - ECD73 in Crayfish Using LC/MS/MS. Project Number: DUPONT/31473/OCR, ABC/66393/M. Unpublished study prepared by ABC Laboratories, Inc . 860.1340 48930705 Henze, R.; Wadsley, M.; Stry, J. (2011) Analytical Method for the Determination of Chlorantraniliprole and Met abolites in Poultry Tissues and Eggs Using LC/MS/MS. Project Number: DUPONT/31085/OCR. Unpublished study prepared by DuPont Crop Protection. 860.1500 48930701 Rice, F. (2012) Magnitude of Chlorantraniliprole Residues in Rice and Crayfish Following Seed Treatment with Chlorantraniliprole (DPX - E2Y45) FS [50% (w/w)] - U.S., 2011 - 2012. Project Number: DUPONT/30021/OCR, ABC/66393. Unpublished study prepared by ABC Laboratories, Inc. 860.1500 48930707 Rice, F. (2012) Magnitude of Chlorantraniliprole Resi dues in Coffee Following Foliar Applications with Chlorantraniliprole (DPX - E2Y45) 35WG - U.S., 2011. Project Number: DUPONT/30023/OCR, ABC/66392. Unpublished study prepared by ABC Laboratories, Inc. 860.1500 48930708 Rice, F. (2012) Magnitude of Chlorantraniliprole Residues in Strawberries Following Foliar Applications with Chlorantraniliprole (DPX - E2Y45) 20SC [200 g/L (w/v);18.4% (w/w] - U.S. and Canada, 2011. Project Number: DUPONT/30024/OCR, ABC/66391. Unpublished study prepared by ABC Laboratorie s, Inc . 860.1500 49076103 Dorschner, K. (2012) Chlorantraniliprole: Magnitude of the Residue on Cherry, Papaya and Lychee. Project Number: B10204/OCR, B10204/09/FLR18, B10204/09/FL69. Unpublished study prepared by University of Hawaii. 860.1500 49076101 Dorschner, K. (2010) Chlorantraniliprole: Magnitude of the Residue on Greenhouse Cucumbers. Project Number: 10004/OCR, 10004/08/FLR07, 08/MD21. Unpublished study prepared by University of Maryland/LESREC, Colorado State University and Interregio nal Research Project No. 4. 860.1500 49076102 Dorschner, K. (2009) Chlorantraniliprol: Magnitude of the Residue on Greenhouse Tomato. Project Number: 09477/OCR, 09477/07/FLR09, 09477/07/CO06. Unpublished study prepared by Colorado State University. 860.1500 49076104 Dorschner, K. (2012) Chlorantraniliprole: Magnitude of the Residue on Green Onion (Fresh and Dried) and Dill Seed. Project Number: A10204/OCR, A10204/09/FLR17, A10204/09/CA/99. Unpublished study prepared by University of California . 8 60.1500 49071201 Rice, F. (2012) Magnitude of Chlorantraniliprole Residues in Peanuts Following Foliar Applications with Chlorantraniliprole (DPX - E2Y45) 20SC [200 g/L (w/v); 18.4% (w/w)] - U.S., 2011. Project Identification Numbers: DuPont - 31666, ABC 6666 4. Unpublished study prepared by ABC Laboratories and E.I. du Pont de Nemours and CompanyChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 3 of 44 **Table of Contents** 1.0 Executive Summary ................................ ................................ ................................ ............ 5 2.0 Regulatory

Recommendations ................................ ................................ ............................ 5 2.1 Data Deficiencies/Data Needs ................................ ................................ .......................... 5 2.2 Tolerance Considerations ................................ ................................ ................................ . 5 2.2.1 Enforcement Anal ytical Method ................................ ................................ ............... 6 2.2.2 Recommended Tolerances ................................ ................................ ........................ 6 2.2.3 Revisions to Petitioned - For Tolerances ................................ ................................ .... 7 2.2.4 International Harmonization ................................ ................................ ..................... 7 3.0 Introduction ................................ ................................ ................................ ......................... 8 3.1 Chemical Identity ................................ ................................ ................................ ................ 8 3.2 Phy sical/Chemical Characteristics ................................ ................................ ................... 9 3.3 Pesticide Use Pattern/Directions for Use (860.1200) ................................ ..................... 10 4.0 Metabolite/Degradate Residue Profile ................................ ................................ .............. 12 4.1 Nature of the Residue ................................ ................................ ................................ ..... 12 4.1.1 Summary

of Plant Metabolism (860.1300) ................................ ............................. 13 4.1.3 Summary

of Confined Rotational Crops (860.l850) ................................ ............... 14 5.1 Residue Anal ytical Methods (860.1340) ................................ ................................ ........ 14 5.1.1 Data Collection Methods ................................ ................................ ........................ 14 5.1.2 Multi - Residue Methods (860.1360) ................................ ................................ ........ 17 5.1.3 Tolerance Enforcement Methods ................................ ................................ ............ 17 5.1.4 Submittal of Analy tical Reference Standards (860.1650) ................................ ...... 18 5.2 Storage Stability

(860.1380) ................................ ................................ .......................... 18 5.3.1 Crop Field Trials (860.1500) ................................ ................................ .................. 19 49071201.der ................................ ................................ ................................ ........................ 20 5.3.2 Field Rotational Crops (860.1900) ................................ ................................ ......... 29 5.3.3 Processed Food and Feed (860.1520) ................................ ................................ ..... 30 5.3.4 Meat, Milk, Poultry and Eggs (860.1480) ................................ .............................. 31 5.3.4.1 Dietary

Burden ................................ ................................ ................................ 31 5.3.4.2 Estimated Secondary Residues in Livestock ................................ ................... 31 5.3.5. Food Handling (860.1460) ................................ ................................ ...................... 31 5.3.6 Water, Fish, and Irrigated Crops (860.1400) ................................ .......................... 31 6.0 Tolerance Derivation ................................ ................................ ................................ ........ 32Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 4 of 44 Appendix A. International Residue Limits Table ................................ ................................ ........ 34 Appendix B. OECD MRL Calculation Procedure Inputs/Outputs ................................ .............. 35Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 5 of 44 **1.0 Executive Summary**  Adequate field trial data were submitted to support use on greenhouse tomato, greenhouse pepper, and greenhouse cucumber. The existing tolerances from field u se cover the expanded use pattern. Condition of registration data submitted for field trials for rice, coffee, and strawberry confirm the existing tolerances. A study submitted as confirmatory data for crayfish supports a lowering of the crayfish tolerance. A condition of registration requirement for an analy tical method for data collection for poultry commodities has been fulfilled. Condition of registration data on field trial residue decline for cherry , papaya, and leechee support existing tolerances for certain tropical fruits and allow for lowering of the PHIs from 10 day s to 1 day , with an increase in tolerance from 2 ppm to 4 ppm, for papaya and passionfruit. Adequate field trial data were submitted to support new uses on peanuts and the green onion subgroup 3 - 07B. Additional field trial data support an increase in the spice subgroup 19B tolerance. Crop group conversions for the tree nut group, pome fruit group, and stone fruit group are acceptable. The tolerances for may haw and pistachio will be removed with their addition to the pomefruit and tree nut groups, respectivel y. **2.0 R** **egulatory R ecommendations**  There are no residue chemistry considerations that would preclude granting the requested registration and establishing the recommended tolerances for chlorantraniliprole on peanuts and the green onion subgroup 3 - 07B. A modified Section F must be submitte d to request a change in the crayfish tolerance to 0.01 ppm and a change in the spice subgroup 19B tolerance to 90 ppm. Likewise, the requested crop group conversions are acceptable. Condition of registration requirements for field trials on strawberry , coffee, and rice have been fulfilled. A condition for registration requirement for crayfish trials has been fulfilled. A condition of registration requirement for an anal yt ical method for data collection for poultry commodities has been fulfilled. The s pecific tolerance recommendations are discussed in 2.2, and label modifications are discussed in section 2.3 **2.1 Data Deficiencies/Data Needs**  There are no data deficiencies related to the present submission. **2.2 Tolerance Considerations** Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 6 of 44 **2.2.1 Enforcem**  **ent Analytical Method**  An adequate enforcement method ( liquid chromatography/tandem mass spectrometry ( LC /MS/MS ) , DuPont - 11374) is available for the determination of chlorantraniliprole residues in/on plant commodities . The purified extract is analyzed b y LC/MS/MS operating in the positive ionization mode. For the determination of chlorantraniliprole, the following ion transitions are monitored (m/z 484  453, 484  286, 284  112, 284  177). The limit of quantitation ( LO Q ) is reported at 0.01 ppm for parent chlorantraniliprole. The L C/MS/MS method was adequatel y validated on a variety of matrices: corn fodder, raisins, grapes, soybean seed, cotton gin trash, white rice, brown rice, tomato, bell pepper, lettuce, and tea leaves and an acceptable Independent Laboratory Validation ( ILV ) study

was conducted on apples, wheat grain, and almond nutmeat. The method for the determination of chlorantraniliprole and its metabolites in processed commodities is a LC /MS/MS method, DuPont - 14314, which is a slightly modified version of DuPont - 11374. These methods have been accepted by the Analy tical Chemistry

Branch (ACB)/Biological and Economical Anal ys is Division (BEAD; DP#340358 , C . Stafford, 02 / 0 6/20 0 8). An adequate enforcement method (L C/MS/MS) is available for the determination of residues of chlorantraniliprole and its metabolites in/on animal commodities. Atmospheric p ressure c hemical i onization (APCI) MS/MS detection operated in the positive ion mode is used . The LOQ is reported at 0.010 pp m for the parent and each of the metabolites. The method has been accepted b y ACB/BEAD (DP# 340 358 , C. Stafford, 02 / 0 6/20 0 8). **2.2.2 Recommended Tolerances**  The current tolerance definition is found at 40CFR§180.628. Compliance with the tolerance is based on measuring o nl y chlorantraniliprole for both plant and animal commodities. **Table 2.2.2**  **. Tolerance Summary for Chlorantraniliprole**  **Comm odity**  **Established/Proposed Tolerance (ppm)**  **HED -**  **Recommended Tolerance (ppm)**  **Comments**

**( correct commodity definition**  **)** Papaya 2.0 4.0 Passionfruit 2.0 4.0 Peanut, nutmeat 0.06 0.06 Peanut, hay 0.20 (exp 04/10/14) 90 proposed 90 Translation from alfalfa hay Onion, green, subgroup 3 - 07B 3 .0 3.0 Spice subgroup 19B 14 1 established/40 proposed 90 Nut, tree, group 14 - 12 0.04 0.02 Crop group conversion . International harmonization. Nut, tree, group 14 0.04 Remove Replaced by crop group 14 - 12 Pistachio 0.04 Remove Replaced by crop group 14 - 12 Fruit, pome, group 11 - 10 1.2 1.2 Crop group conversion Fruit, pome, group 11, except mayha w 1.2 Remove Replaced by crop group 11 - 10Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 7 of 44 May ha w 0.6 Remove Replaced by crop group 11 - 10 Fruit, stone group 12 - 12, except cherry, Chickasa w plum, and damson plum 4.0 4.0 Crop group conversion Fruit, stone group 12, except cherry, Chickasa w plum, and damson plum 4.0 Remove Replaced by crop group 12 - 12 Crayfish 8.0 0.01 Onion, green 0.20 (exp 04/10/14) Remove Replaced by Onion, green, subgroup 3 - 07B Onion, welsh 0.20 (exp 04/10/14) Remove Replaced by Onion, green, subgroup 3 - 07B Shallots, fresh leaves 0.20 (exp 04/10/14) Remove Replaced by Onion, green, subgroup 3 - 07B Leek 0.20 (exp 04/10/14) Remove Replaced by Onion, green, subgroup 3 - 07B 1 A tolerance of 14 ppm was recommended (D361791, D. Rate, 01/08/2010), but is not listed in 40CFR§180.628 . This was based on the translation of alfalfa seed data, with adjustments for adjuvant use (2x) and application rate (2x). **2.2.3 Revisions to Petiti**  **oned -**  **For Tolerances** The petitioned tolerances are the same as the recommended tolerances, except for spice subgroup 19B and crayfish. Residue data on dill seed was presented in support of a spice subgroup 19B tolerance. HED had previously recommended fo r a spice subgroup 19B tolerance of 14 ppm. The petitioner requested 40 ppm, but evaluation of the dill seed data indicates that 90 ppm is appropriate. See Appendix B. A crayfish tolerance of 8 ppm was previousl y established based on a fish bioconcentration study and the estimated residues in water, s ediment, and rice straw . The present crayfish study showed no residues (<0.01 ppm) at various sampling intervals from the use of chlorantraniliprole as a seed treatment on rice. This reflects the actual us e pattern. A tolerance of 0.01 ppm is appropriate. A modified Section F is required. A crop group conversion for tree nut group 14 to tree nut group 14 - 2 was requested. This is acceptable, but the tolerance will be changed from 0.4 ppm to 0.2 ppm to harmonize with Canada and Codex. The registrant must submit a revised Section F requesting tolerances of 90 ppm and 0.01 ppm for the spice subgroup 19B and crayfish , respectively . **2.2.4 International Harmonization**  Residue definitions are harmonized among the US, Canada, and Codex, with the common definition chlorantraniliprole. Relevant maximum residue limits ( MRL s ) are summarized in the International Residue Limits (IRL ) table in Appendix A .Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 8 of 44 The existing US tolerance for the tree nut group is 0.04 ppm, whereas the tolerance in both Canada and Codex is 0.02 mg/kg. The US tolerance is based upon the evaluation of field trial data for pecans and almonds with the use of the North American Free Trade Agreement (NAFTA) st atistical spreadsheet (N. Tsaur , D357727, 03/03/2009). The data were reevaluated using the current procedure, the OECD spreadsheet , as shown in Appendix B. The new tolerance estimate is 0.02 ppm. Therefore, the tolerance for tree nuts, including pistachio, is lowered to 0.02 ppm, and harmonization with Canada and Codex is achieved. The existing US tolerance for the pome fruit group is 1.2 ppm. The Codex MRLfor pome fruit is 0.4 ppm, and the Canada MRLfor various pome fruits (apple, pear, mayhaw , quince ) is 0.4 ppm. The original US tolerance for pome fruits was 0.3 ppm, but it was adjusted upwards to 1.2 ppm to accommodate the use of adjuvants and a shortened PHI (D361791, D. Rate, 01/08/2010) . Therefore, the 1.2 ppm value cannot be lowered to har monize with Codex and/or Canada. The existing US tolerance for the stone fruit group (except cherry , chickasaw plum, and damson plum) is 4.0 ppm. The Codex MRL for stone fruits is 1 mg/kg and the Canada MRL for various stone fruits (apricot, nectarine, p each, plum , plumcots, cherries ) is 2.5 mg/kg. The original US tolerance for stone fruits was 1.0 ppm, but it was adjusted upwards to 4.0 ppm to accommodate the use of adjuvants and a shortened PHI (D361791, D. Rate, 01/08/2010). Therefore, the 4.0 ppm value cannot be lowered to harmonize with Codex and/or Canada. Codex has not established MRL s for passionfruit, papaya, peanuts, green onions, herbs, or spices. Therefore, there is no harmonization issue with Codex. Canada does not have MRL s for these sam e commodities, with the exception of green onions and peanuts . Canada and the US are conducting a joint review for green onions and peanuts and have agreed upon harmonize d MRLvalues. **2.3 Label Recommendations**  The proposed labels are acceptable. **3.0 Introduction**  Chlorantraniliprole (DPX - E2Y45) is an anthranilic acid (or 2 - aminobenzoic acid) diamide insecticide belonging to a class of compounds that acts on the ryanodine receptor. Section 3 registrations of chlorantraniliprole for use in the United S tates have been approved for the numerous crop groups or crop subgroups and individual commodities. Chlorantraniliprole is registered to E.I. du Pont de Nemours and Company (DuPont). **3.1 Chemical Identity** Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 9 of 44 **Table 3.1. Chlorantraniliprole Nom**  **enclature.** Chemical structure

Common name Chlorantraniliprole Company experimental name DPX - E2Y45 IUPAC name 3 - bromo - 4 ′- chloro - 1 - (3 - chloro - 2 -pyridyl) - 2 ′ - methyl - 6 ′ - (methylcarbamoyl)pyrazole - 5 - carboxanilide CAS name 3 - bromo -N - [4 - chloro - 2 - methyl - 6 - [(methylamino)carbonyl]phenyl] - 1 - (3 - chloro - 2 - pyridinyl) - 1 H

- py razole - 5 - carboxamide CAS registry number 500008 - 45 - 7 End -use product (EP) DuPontTM Altacor® WG (35%; EPA Reg. No. 352 - 730) DuPontTM Coragen® SC Insect Control ( 1.67 lb ai/gal; EPA Reg. No. 352 - 729) DuPontTM Dermacor® X - 100 Seed Treatment ( FS, 5.21 lb ai/gal; EPA Reg No. 352 - 820) **3.2 Physical/Chemical Characteristics**  The log octanol/water partition coefficient is <3 over a range of pHs , suggesting that chlorantraniliprole is not highl y soluble in fat - ty pe matrices and hydrocarbon solvents. This is confirmed b y the solubility data in water and various organic solvents. The low vapor pressure means low volatility . **Table 3.2**  **. Physico**  **chemical Properties of Tec hnical Grade of Chlorantraniliprole**  **.** Parameter Value Reference Melting point/range (°C) 200 - 202 (95.9%)/208

– 210 (99.2%) 46889033 pH 5.77 ± 0.087 at 20 ° C 46889031 Relative Density 1.5189 (95.9%)/1.507 (99.2%) at 20 ° C 46889033 Water solubility (20°C) Deionized Water 1.023 mg/L pH 4 0.972 mg/L pH 7 0.880 mg/L pH 9 0.971 mg/L 46889026 Solvent solubility (20°C) Acetone 3.446 ± 0.172 g/L Acetonitrile 0.711 ± 0.072 g/L Ethyl Acetate 1.144 ± 0.046 g/L Dichloromethane 2.476 ± 0.058 g/L Dimethylformamide 124 ± 4 g/L n - Octanol 0.386 ± 0.01 g/L Methanol 1.714 ± 0.057 g/L n - Hexane < 0.0001 g/L o - Xylene 0.162 ± 0.01 g/L 46889030 **N N**  **N N**  **H O**  **Cl Br**  **N H**  **O Cl** Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 10 of 44 **Table 3.2**  **. Physico**  **chemical Properties of Tec hnical Grade of Chlorantraniliprole**  **.** Parameter Value Reference Vapor pressure 6.3 x 10 - 12 Pa @ 20 ° C, 2.1 x 10 - 11 Pa @ 25 ° C 46889130 Dissociation constant, pKa 10.88 ± 0.71 46889034 Octanol/water partition coefficient, KOW (20°C) Deionized Water 589 pH 4 588 pH 7 721 (log 2.8) pH 9 654 46889032 UV/visible absorption (max) pH <2 no absorption max >200 nm, at 290 ε = 3941 pH 7 no absorption max >200 nm, at 290 ε = 4185 pH >10 absorption max at ~320 nm which may be due to decomposition of DPX - E2Y45, at 290 ε = 6082 46889027

**3.3 Pesticide Use Pattern/** **Directions for Use (860.1200)**  Table 3.3 . Summary of Proposed Directions for Use of Chlorantraniliprole Applic. Timing, T ype, and Equip. Form

ulation [EPA Reg. No.] Applic. Rate

(lb ai/A) Max.

No. Applic. per Season Max. Seasonal

Applic. Rate (lb ai/A) PHI

(days) Use Directions and

Limitations Peanut Foliar (ground; aerial ) 18.4% SC

1.67 lb ai/gal Coragen (352 - 729) 0.045

–

0.065 4 0.2 (from all chlorantranili prole sources) 1 Minimum interval between treatments is 3 days. Foliar (ground; aerial ) 5% SC

0.43 lb ai/gal Prevathon (352 - 844) 0.047 - 0.067 4 0.2 (from all chlorantranili prole sources) 1 Minimum interval between treatments is 3 days. Bulb Vegetables (including green onion subgroup) Foliar (ground; aerial ) 18.4% SC

1.67 lb ai/gal Coragen (352 - 729) 0.045

–

0.065 4 0.2 per crop 0.6 per year (from all chloroantranili

-prole sources) 1 Minimum interval between treatments is 4 days. Greenhouse Cucumbers, Greenhouse Peppers, Greenhouse Tomatoes

Foliar 18.4% SC

1.67 lb ai/gal Coragen (352 - 729) 0.031

tomato 0.045 pepper, cucumber 3 (per

crop cycle) 0.134 per crop

cycle 1 Minimum interval between treatments is 7 days. Mix 1.6 fl oz per 100 gal spray volume (0.0 209 lb ai/100 gal) Maximum application is 150 gal spray solution per acre for tomato and 214 gal spray solution per acre for cucumber and pepper. Tropical Fruits Foliar 35.0% 0.066 - 0.099 3 0.2 (from all 1 1 Minimum intervalChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 11 of 44 Table 3.3 . Summary of Proposed Directions for Use of Chlorantraniliprole Applic. Timing, T ype, and Equip. Form

ulation [EPA Reg. No.] Applic. Rate

(lb ai/A) Max.

No. Applic. per Season Max. Seasonal

Applic. Rate (lb ai/A) PHI

(days) Use Directions and

Limitations WDG Altacor (352 - 730) chloroantranili

-prole sources) 10

(acerol a, jabotic aba, and lychee ) between treatments is 7

days. Do not apply dilute solutions of more than 200 gal water per acre. Do not apply less than 30 gal wate r per acre Lo w growing berry (subgroup 13 - 07G)

Foliar 35.0%

WDG Altacor (352 - 730) 0.066 - 0.099 3 0.2 (from all chloroantranili

-prole sources) 1 Minimum interval between treatments is 7 days. Do not apply dilute solutions of more than 200 gal water per acre. Do not apply less than 30 gal water per acre. Do not apply to straw berry or cranberry.

Foliar 18.4% SC

1.67 lb ai/gal Coragen (352 - 729) 0.045 - 0.065 4 0.2 per crop (from all chloroantranili

-prole sources) 0.4 per year (from all chloroantranili

-prole sources) 1 Minimum interval between treatments is 7 days. Rice

Seed treatment 50% FS

5.21 lb ai/gal Dermacor X - 100 0.084 1 N/S N/S Do not use DERMACOR® X - 100 treated rice field for the aquaculture of edible fish or Crustacea (including crawfish) during the rice production cycle (planting through harvest). Coffee Foliar 35.0%

WDG Altacor (352 - 730) 0.066 - 0.099 3 0.2 (from all chloroantranili

-prole sources) 7 Minimum interval between treatments is 14days. Do not apply dilute solutions of more than 200 gal water per acre. Do not apply less thanChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 12 of 44 Table 3.3 . Summary of Proposed Directions for Use of Chlorantraniliprole Applic. Timing, T ype, and Equip. Form

ulation [EPA Reg. No.] Applic. Rate

(lb ai/A) Max.

No. Applic. per Season Max. Seasonal

Applic. Rate (lb ai/A) PHI

(days) Use Directions and

Limitations 30 gal water per acre. Herb Subgroup 19A

Foliar 18.4% SC

1.67 lb ai/gal Coragen (352 - 729) 0.045

–

0.065 4 0.2 per crop (from all chloroantranili

-prole sources) 0.8 per year (from all chloroantranili

-prole sources) 1 Minimum interval between treatments is 3 days. Spices Subgroup 19B

Foliar 18.4% SC

1.67 lb ai/gal Coragen (352 - 729) 0.045

–

0.065 4 0.2 per crop (from all chloroantranili

-prole sources) 0.8 per year (from all chloroantranili

-prole sources) 1 Minimum interval between treatments is 3 days.

1 The PHI for papaya and passionfruit has been reduced from 10 days to 1 day. Conclusions . The label information is adequate to allow evaluation of the residue data relative to the proposed uses. No label changes are needed for the uses presented in Table 3.3. **4.0 Metabolite/Degradate**  **Residue Profile 4.1**  **Nature of the Residue** The nature of the residue in plants is adequatel y understood. HED has determined that parent chlorantraniliprole is the residue of concern in plant commodities for tolerance expression and risk assessment (DP#3 43519 , C. Olinger, 02/29/2008 ). The HED’s ROCKS ( DP#343519 , C. Olinger, 02/29/2008 ) previously determined that the residue of concern in ruminants is chlorantraniliprole for the purposes of the tolerance expression . ROCKS also determined that the residue of concern in ruminants is chlorantraniliprole for the purposes of risk assessment, unless the level of the dietary burden significantl y increased. With an increase of dietary burden of ruminants, for risk assessm ent purposes, the following metabolites are now included: IN - HXH44 and IN - K9T00 . Upon consultation with members of ROCKS, the chlorantraniliprole risk assessment team previousl y determined that the residue of concern for the tolerance expression in poultry is chlorantraniliprole and that metabolites (IN - H2H20, IN - K7H29 and IN - GAZ70) would beChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 13 of 44 included with chlorantraniliprole in the risk assessment for eggs. However, the poultry feeding study revealed concentrations of metabolites IN - H2H20, IN - F9N04, IN - K7H 29, and IN - GAZ70 often equal to the concentration of chlorantraniliprole in liver, eggs, meat, and fat (with skin). These metabolites are structurally similar to the parent (Appendix I). Therefore, the residue definition for dietary risk assessment in po ultry commodities was altered to be the sum of chlorantraniliprole and metabolites IN - H2H20, IN - F9N04, IN - K7H29, and IN - GAZ70, calculated as chlorantraniliprole (D404708, S. Funk, 09/10 /2013 ) . **4.1.1 Summary of Plant Metabolism (860.1300)**  Studies have been conducted depicting the metabolism of chlorantraniliprole in apple, cotton , lettuce , rice, and tomato (DP#336941, L . Cheng, 02/25/2008) . In the apple, cotton, lettuce and tomato studies, the plants were treated at 3 x 100 g ai/ha by foliar application (~ 0.5x proposed maximum application rate), and rice was treated at 1 x 150 g ai/ha by soil drench (0.68x, based on the proposed Section 18 use). Total radioactive residues were measured in apples (0.092 and 0.138 ppm at 15 - and 30 - day PHI s, respectivel y), lettuce (0.301 and 0.372 ppm at 7 - and 15 - day PHI s, respectivel y) , cottonseed (<0.01 ppm at 126 - day PHI), tomato (0.056 and 0.013 ppm at 7 - and 15 - day

PHIs, respectively), and rice (0.155 ppm at 132 - day PHI). For apple, lettuce and tomato, the majority

of the residues were surface residues. In all these crops, unchanged chlorantraniliprole was the major residue (57 - 92% of the total radioactive residue ( TRR) ) . Very little degradation of chlorantraniliprole was observed in apple, cotton, lettuce and tomato. Many metabolites were found in rice commodities and the metabolism in rice generall y involves: (i) hydroxylation of the N - methyl group (to IN - H2H20) or h ydrox yl ation of the tolyl methyl group (to IN - HXH44) ; (ii) cyclization with loss of w ater to a quinazolinone derivative (IN EQW78); and similar condensation of IN - H2H20 with an additional loss of CH 2 O (to I N GAZ70) ; and (iii) N - demethylation via IN - H2H20 to IN - F9N04. **4.1.2 Summary of Livestock Metabolism (860.1300)**  DP#343519, C. Olinger , 2/29/2008 (Residues of Concern Knowledgebase Subcommittee) DP#336941, L. Cheng, 2/25/2008 (PP#7F7181) DP#361791, D. Rate, 01/08/2010 (PP#9F7513) Adequate metabolism studies with chlorantraniliprole in hens and goats have been reviewed (DP#336941, L . Cheng, 02/25/2008) . The metabolic fate of chlorantraniliprole in livestock was investigated b y the conduct of radiolabeled studies in laying hens and lactating goats. Following oral administration to laying hens, chlorantraniliprole and its metabolites were eliminated in the excreta (>98% of the dose). Eggs and edible tissues contained approximately 3% of the total administered dose. The major components of the radioactivity in eggs were parent chlorantraniliprole (12 - 23% TRR in egg yolk; 26 - 32% TRR in egg white) and IN - GAZ70 (4 - 7% TRR in egg yolk; 33 - 40% TRR in egg white); and parent chlorantraniliprole was the major component in skin with fat (18% TRR). Chlorantraniliprole was also detected in liver (4% TRR) and muscle (4% TRR). The poultry feeding s tudy , reviewed below, revealed significant concentrations of several metabolites in poultry commodities. When 14 C - chlorantraniliprole was orally administered to a lactating goat at 10 ppm in the feed, aChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 14 of 44 large proportion of the dose was eliminated in the excreta (93.57% of the dose). Milk, liver, and kidney combined contained approximately 1% of the administered total dose. Parent chlorantraniliprole was the major component of the extracted radioactivity identified in kidney , muscle, and fat samples and was also identified in liver. The radioactivity in fat was higher than in muscle, indicating that chlorantraniliprole and its residues are likely to be designated as “fat soluble.” The entire radioactivity in milk was extracted. Three metabolites were i dentified in addition to chlorantraniliprole in the extracts. Unchanged parent compound accounted for 23.58% TRR (0.016 ppm, 0.19% dose). The three metabolites were IN - K9T00 at 26.1% TRR (0.017 ppm, 0.21% dose), IN - HXH44 at 26.92% TRR (0.018 ppm, 0.21% d ose), and IN - HXH40 at 5.87% TRR (0.004 ppm; 0.05% dose). **4.1.3 Summary of Confined Rotational Crops (860.l850)**  DP#336941, L. Cheng, 2/25/2008 (PP#7F7181) Acceptable c onfined rotational crop studies have been reviewed and deemed adequate to satisfy data requirements . Unchanged parent was the major identified residue in all rotational crop commodities including lettuce (64 - 85% TRR), wheat grain (48% TRR from an exaggerated rate at 120 DAT), wheat forage (54 - 84% TRR), wheat hay (51 - 73% TRR), and wheat straw (37 - 69% TRR); TRR were <0.01 ppm in wheat grain, beet root, and beet foliage. HED (DP#343519, C. Olinger, 2/29/2008) has determined that the parent compound is the residue of concern in rotational crops for the purposes of tolerance expression and risk assessment. **5.1 Residue Analytical Methods (860.1340)**  **5.1 .1**  **Data Collection Methods** 48930702.der 48930705.der LC/MS/MS method DuPont - 13294, a modification of the enforcement method, was utilized for the anal ys is o f chloranatranilirprole in plant commodities. Briefl y, samples were hydrated and then extracted twice with acetonitrile (ACN) and filtered. An aliquot of the extract was evaporated to dry

ness under a stream of nitrogen, reconstituted in ACN:water (40:60, v:v), and filtered for anal ys is by

LC/MS/MS. The L OQ (determined as the LLMV) was 0.01 ppm for chlorantraniliprole in/on cucumbers, tomato, green onion, strawberry , peanut, lychee, cherry , papaya, and rice grain . In this submission , E.I . du Pont de Nemours and Company (DuPo nt) has provided validation data for anal ytical method 31085 for the determination of residues of chlorantraniliprole and metabolites IN - H2H20, IN - F9N04, IN - K7H29, IN - GAZ70, and IN - EQW78 in poultry tissues and eggs. This is a data collection method. Bri efl y, homogenized samples are extracted once with water, acetonitrile (ACN), and hexane and once with ACN and hexane using a Genogrinder. After centrifugation, the ACN layers are combined and diluted to volume with ACN. For egg commodities (whole egg, eg g white, andChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 15 of 44 egg yolk), an aliquot is evaporated to dry ness and redissolved in ACN, methanol, and water for anal ys is by

liquid chromatography

/tandem mass spectrometry (L C/MS/MS). For poultry tissues, an aliquot is cleaned up on an Oasis Hydrophobic - Lipoph ilic Balance (HLB) solid - phase extraction (SPE) cartridge using ACN followed by 0.5% formic acid in ethyl acetate to elute residues; the eluate is diluted to volume with ACN, and an aliquot is evaporated to dry ness and redissolved in ACN, methanol, and wat er for analy sis by L C/MS/MS. L C/MS/MS analysis is conducted in the positive ion mode monitoring at least two ion transitions for each anal yt e; one ion transition is used for quantitation and the relative ratio of the fragment ions is used for confirmation of analy

te presence. The method included an alternate extraction procedure for egg commodities. Homogenized egg samples are mixed with water and extracted with ACN and hexane using a homogenizing probe. After centrifugation, the ACN layer is removed an d the remaining hexane and solids are extracted with ACN using the homogenizing probe. The mixture is centrifuged and the ACN layers are combined and diluted to volume with ACN. An aliquot is mixed with concentrated formic acid and then evaporated to dry ness and redissolved in ACN, methanol, and water for LC/MS/MS analy sis. The method using the Genogrinder extraction was validated with samples of whole eggs, poultry muscle, poultry

liver, and poultry

fat fortified with chlorantraniliprole and metabolites IN H2H20, IN - F9N04, IN - K7H29, IN - GAZ70, and IN - EQW78 at 0.010 and 0.10 ppm each. Reasonabl y acceptable method validation recoveries were obtained for all analy tes in every matrix using this method. Recoveries [and coefficients of variation (CVs)] of chlorantraniliprole, IN - H2H20, IN - F9N04, IN - K7H29, IN - GAZ70, and IN - EQW78 ranged from 80 - 120% (2.0 - 8.3%) in whole eggs; from 89 - 123% (1.6 - 13.9%) in muscle; from 85 - 116% (2.7 - 9.6%) in liver; and from 83 - 157% (1.2 - 9.2%) in fat. With few exceptions, individual recoveries were within the acceptable range of 70 - 120%. High recoveries were obtained for chlorantraniliprole from fat (all samples; 122 - 157%), for IN - H2H20 from muscle (121%), and for IN - F9N04 from muscle (123%). The method using the homogenizing probe was validated with samples of whole eggs, egg whites, and egg yolks fortified with chlorantraniliprole an d metabolites IN - H2H20, IN - F9N04, IN - K7H29, IN - GAZ70, and IN - EQW78 at 0.010 and 0.10 ppm each. Reasonably acceptable method validation recoveries were obtained for all anal yt es using this method. Recoveries (and CVs) of chlorantraniliprole, IN - H2H20, IN - F9N04, IN - K7H29, IN - GAZ70, and IN - EQW78 ranged from 81 - 128% (4.3 - 14.8%) in whole eggs; from 74 - 122% (2.2 - 17.2%) in egg whites; from 87 - 127% (1.9 - 10.7%) in egg yolks. High recoveries were obtained for chlorantraniliprole from egg yolks (127%), for IN - GAZ70 from whole eggs (122, 128, and 128%), and for IN F9N04 from egg whites (122%). The limit of quantitation (LOQ), based on the lowest level of method validation (LLMV), is 0.010 ppm for each anal yte in each matrix.Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 16 of 44 In this submission , DuPont provided a data collection method (DuPont 31473) for the determination of chloranatraniliprole and metabolite I N - ECD73 in crayfish. The method is similar to the livestock commodity enforcement method. Briefl y, s amples are extracted once with purified water, acetonitrile (ACN), and hexane b y shaking. After centrifugation, the lower ACN/water layer is extracted again using ACN, and any remaining hexane is removed from the combined ACN/water layers by nitrogen evaporation. The extract is diluted to volume with ACN, and an aliquot is mixed with ACN:0.01 M aqueous formic acid (75:25, v:v). The extract is filtered through a 0.45 - μm poly tetrafluoroethylene sy ringe filter for anal ys is by liquid chromatography

/tandem mass spectrometry (LC/MS/MS). LC/MS/MS analy sis is conduc ted in the positive ion mode, monitoring ion transitions amu 484.0 to 286.0 for chlorantraniliprole and 279.2 to 244.0 for IN - ECD73. The method was validated with samples of crayfish fortified at 0.010 and 0.100 ppm for both chlorantraniliprole and IN - ECD 73. Acceptable method validation recoveries were obtained. Recoveries of chlorantraniliprole and IN - ECD73 ranged from 83 - 103% (average of 95% and standard deviation of 6%) and from 82 - 105% (average of 92% and standard deviation of 6%), respectivel y. Indi vidual recoveries at each fortification level were within the acceptable range of 70 - 120%, and coefficients of variation (CVs) ranged from 1.2 - 10%. The limit of quantitation (LOQ), based on the lowest level of method validation (LLMV), is 0.010 ppm for ea ch anal yte. The solvents used for the extraction of samples in this method are the same as those used in the crayfish toxicity

study (DuPont Report No. 24137). Therefore, radiovalidation data for this method are not required. Conclusions. For data coll ection, LC/MS/MS method DuPont - 13294 was used for the analy sis of chlorantraniliprole residues in samples from the field trial studies submitted in conjunction with the subject petitions. The adequacy of data - collection methods was verified with method recoveries in the acceptable 70 - 120% range. DuPont - 31085 was utilized for the anal ys is of samples from a poultry feeding study . The adequacy of data - collection methods was verified with method recoveries in the acceptable 70 - 120% range , except as note d above. Method DuPont 31473 is acceptable as a data collection method for residues of chlorantraniliprole and IN - ECD73 in crayfish. The limits of quantitation (LOQs), based on the lowest levels of method validation (LLMVs), were 0.010 ppm for chlorantraniliprole in crayfish and 0.010 ppm for IN - ECD73 in crayfish. The method was adequate for data collection based on acceptable concurrent recoveries, as well as method validation for both analy tes in crayfish. The method may

be used for enforcement of toler ance purposes, based on its similarity to the livestock enforcement method (DuPont 11376). An ILV study is not required.Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 17 of 44 **5.1.2 Multi**  **- Residue Methods (860.1360)**  DP#336941, L. Cheng, 2/25/08 (PP#7 F 7181) Multiresidue data for chlorantraniliprole are available. The study evaluated chlorantraniliprole using the appropriate FDA multiresidue methods as outlined in the FDA Pesticide Analytical Manual , Volume I, Third Edition (January 1994). Testing of Protocol A was not conducted since chlorantraniliprole does not naturall y fluoresce. Protocol B was not tested since c hlorantraniliprole does not contain a carboxylic acid or phenolic group. When subjected to Protocol C testing, chlorantraniliprole yi elded multiple peaks on different columns and detectors. The recovery

of chlorantraniliprole through Protocol D could not be quantified because of matrix interference. No or low recoveries of chlorantraniliprole were observed through Protocol E and F. Protocol G was not tested since c hlorantraniliprole does not contain a substituted urea function. Conclusions . The requirements for multiresidue methods data are fulfilled. Chlorantraniliprole is not recovered b y the US FDA’s multiresidue methods . **5.1 .3**  **Tolerance Enforcement Methods** DP#345790, L. Cheng, 11/6/2007 (PP#7 F 7181; PMV Request) DP#340358, C. Stafford, 2/6/2008 (ACB/BEAD) DP#336941, L. Cheng, 2/25/2008 (PP#7F7181) 48930705 .der An adequate enforcement method (L C/MS/MS, DuPont - 11374) is available for the determination of chlor antraniliprole residues in/on plant commodities. Briefly , samples are soaked in water before extraction with acetonitrile (ACN). An aliquot of the extract is diluted with water, filtered through a strong anion exchange (SAX) solid phase extraction (SPE) cartridge connected in series with an Oasis hydrophilic - lipophilic balanced (HLB) cartridge. After washing the cartridges with water/acetonitrile, the cartridges are air dried, and the Oasis cartridge is separated from the SAX cartridge. Chlorantraniliprole is eluted from the Oasis cartridge with acetone. The eluant is evaporated to dry ness and the residue is reconstituted in ACN and diluted with water. The extract is anal yzed by L C/MS/MS operating in the positive ionization mode. For the determination of chlorantraniliprole, the following ion transitions are monitored (m/z 484  453, 484  286, 284  112, 284  177). The LOQ is reported at 0.01 ppm for parent chlorantraniliprole. The LC/MS/MS method was adequately validated on a variety of matrices: corn fodder, raisins, grapes, soy bean seed, cotton gin trash, white rice, brown rice, tomato, bell pepper, lettuce, and tea leaves and an acceptable ILV study was conducted on apples, wheat grain, and almond nutmeat. The method for the determination of c hlorantraniliprole and its metabolites in processed commodities is an L C/MS/MS method, DuPont - 14314, which is a slightly modified version of DuPont - 11374. These methods have been accepted b y the Analytical Chemistry Branch (ACB)/Biological and Economical Anal ys is Division (BEAD; DP#340358 , C . Stafford, 02 / 0 6/20 0 8). An adequate enforcement method (L C/MS/MS , Du[pont 11376) ) is available for the determination of residues of chlorantraniliprole and its metabolites in/on animal commodities. Atmospheric p ressure c hemical i onization (APCI) MS/MS detection operated in the positive ionChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 18 of 44 mode is used . The LOQ is reported at 0.010 pp m for the parent and each of the metabolites. The method has been accepted by ACB/BEAD (DP# 340 358 , C. Stafford, 02 / 0 6/20 0 8). Conclusions. A d equate method s are available for the enforcement of tolerances for chlorantraniliprole residues in/on crops ( LC /MS/MS Method DuPont - 11374) and livestock (LC/MS/MS; MRID 46889003) . The LOQs are 0.01 ppm for chlorantraniliprole in crop and l ivestock matrices . **5.1.4 Submittal of**  **Analytical Reference Standards (860. 1650)**  The anal ytical reference standard is available from the EPA National Pesticide Standards Repository . It expires 04/24/2014. **5.2 Storage Stability (860.1380)**  Adequate storage plant commodity stability studies were previously

submitted in conjunction with PP#7F7181 (DP#336941, L . Cheng, 2/25/2008). The study results demonstrate that residues of chlorantraniliprole are reasonabl y stable at approximately - 20  C for at leas t 24 months in diverse crops (apple, grape, tomato, leaf lettuce, cauliflower, potato, wheat grain, wheat straw, alfalfa hay , and cotton seed), including water - , oil - , protein - , and starch - containing commodities as represented by fruits, a fruiting vegetab le, a root crop, a non - oily grain, and an oilseed. Additional study results demonstrate that residues of chlorantraniliprole and its metabolites (IN - ECD73, IN - EQW78, and IN - F6L99) are stable for at least 12 months in processed crop fractions including pre dominantl y water- , oil - , protein - containing, and dry fractions (raisins, ketchup, apple juice, cottonseed meal, and cottonseed oil) stored at approximately - 20oC. Samples of plant commodities from the crop field trial s tudies associated with this petiti on were stored frozen from harvest to analy sis . The storage durations and conditions are presented under the respective field trials. Adequate livestock commodity stability studies were previousl y submitted in conjunction with PP#7F7181 (DP#336941, L . Ch eng, 2/25/2008 ; Monograph B.7 ) . Residues of chlorantraniliprole and its metabolites I

N - HXH44, IN - K9T00, IN - GAZ70 and IN - EQW78 in fortified (each at 0.10 ppm) control samples of bovine liver, kidney , muscle, fat , and milk were shown to be stable during free zer storage for 12 months . A concurrent storage stability study was conducted with the crayfish study

(see 5.3.6). Conclusions The storage stability data are adequate to support the crop field trials considered herein. All commodities were anal yz ed within the interval of demonstrated storage stability . 5.3 Residue DataChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 19 of 44 **5.3.1 Crop Field Trials (860.1500)**  Green (Spring) Onion 49076104.der The Interregional Research Project Number 4 (IR - 4) has submitted field trial data for chlorantraniliprole on green onion (fresh and dried). Five green onion trials were conducted in the NAFTA Growing Zones 1 (QC; 1 trial), 2 (MD; 1 trial), 5A (ON; 1 trial), and 10 (CA; 2 trials. Each trial consisted of one untreated plot a nd one treated plot. At each trial location, the treated plot received two foliar broadcast applications of a 1.67 lb ai/gal suspension concentrate (SC) formulation of chlorantraniliprole ( Coragen® 20SC ) at 0.098 - 0.105 lb ai/A/application for a total seas onal rate of 0.199 - 0.203 lb ai/A. Applications were made at a 3 - to 4 - day retreatment interval (RTI) using ground equipment in spray volumes of 22 - 45 gal/A with a nonionic surfactant (NIS) included in each spray mix. Samples of mature green onion (fresh) were harvested at a preharvest interval (PHI) of 1 day . Additional green onion samples from each site were dried for up to 10 day s prior to collection. S amples were anal yz ed for residues of chlorantraniliprole using a high performance liquid chromato graphy m ethod with L C/MS/MS based on DuPont - 13294. The limit of quantitation (LOQ; determined as the lowest level of method validation, LLMV) was 0.01 ppm in/on green onion. The method was adequate for data collection based on acceptable method validation and concurrent recovery

data. The fortification levels used in method validation and concurrent method recovery

were adequate to bracket expected residue levels. Recoveries and residues in treated samples were not corrected for residues in controls. Samples were stored frozen ( - 38 to - 0.6 °C) from collection to anal ys is for 504 - 734 day s (16.6 - 24.1 months) for green onion. Samples were analyzed within 0 - 5 day s of extraction. To support the sample storage intervals, a concurrent storage stability study was conducted with the field trial study . The data demonstrate that residues of chlorantraniliprole were stable in/on green onion stored frozen for up to 746 day s (24.5 months). No 0 - day data were provided. HED has concluded (see minutes of 6/19/13 Chemistry Science Advisory

Council (ChemSAC) meeting) that recovery

data from 0 - day

fortified samples are desirable for storage stability studies but are not mandatory Following tw o foliar broadcast applications of the 1.67 lb ai/gal SC formulation of chlorantraniliprole at a total rate of 0.19 9 - 0.20 3 lb ai/A, residues of chlorantraniliprole (and per trial averages) in/on fresh green onion and dried green onion respectivel y , harvest ed at a 1 - day PHI , were 0. 371 - 1.50 (0.406 - 1.49) ppm and 0.900 - 11.1 (1.00 - 10.8) ppm. The processing data indicate that residues of chlorantraniliprole concentrate in dried onions (processing factors of 2.1 - 9.6x; median 3.4 ). Dill Seed 49076104.der IR - 4 has submitted field trial data for chlorantraniliprole on dill seed . Two dill seed trials wereChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 20 of 44 conducted in Zones 2 (NC; 1 trial) and 11 (ID; 1 trial). Each trial consisted of one untreated plot and one treated plot. At each trial location, the treate d plot received two foliar broadcast applications of a 1.67 lb ai/gal suspension concentrate (SC) formulation of chlorantraniliprole ( Coragen® 20SC ) at 0.098 - 0.105 lb ai/A/application for a total seasonal rate of 0.199 - 0.203 lb ai/A. Applications were made at a 3 - to 4 - day retreatment interval (RTI) using ground equipment in spray volumes of 22 - 45 gal/A with a nonionic surfactant (NIS) included in each spray mix. Samples of dill seed were harvested at a preharvest interval (PHI) of 1 day . S amples were anal yz ed for residues of chlorantraniliprole using L C/MS/MS based on DuPont 13294. The limit of quantitation (L OQ; determined as the lowest level of method validation, LLMV) was 0.01 ppm in/on green onion and dill seed. The meth od was adequate for data collection based on acceptable method validation and concurrent recovery data. The fortification levels used in method validation and concurrent method recovery were adequate to bracket expected residue levels. Recoveries and res idues in treated samples were not corrected for residues in controls. Samples were stored frozen ( - 38 to - 0.6 °C) from collection to anal ys is for 665 - 737 day s (21.9 - 24.2 months) for dill seed. Samples were anal yz ed within 0 - 5 day s of extraction. To supp ort the sample storage intervals, a concurrent storage stability study was conducted with the field trial study . The data demonstrate that residues of chlorantraniliprole were stable in/on dill seed, stored frozen for up to 797 day s (26.2 months); no 0 - day data were provided. HED has concluded (see minutes of 6/19/13 Chemistry Science Advisory

Council (ChemSAC) meeting) that data for 0 - day

fortified samples are desirable for storage stability studies but are not mandatory Following two foliar broadcast applications of the 1.67 lb ai/gal SC formulation of chlorantraniliprole at a total rate of 0.19 9 - 0.20 3 lb ai/A, residues of chlorantraniliprole (and per trial averages) in/on dill seed, respectivel y, harvested at a 1 - day PHI , were 15.4 - 24.3 ( 17.0 - 19.8 ) pp m . Peanut 49071201.der DuPont has submitted field trial data for chlorantraniliprole on peanuts. Six peanut trials were conducted in the United States in NAFTA Growing Zones 2 (GA, 3 trials), 3 (FL, 1 trial), 6 (TX, 1 trial), and 8 (TX, 1 trial) during the 2011 growing season. The number and distribution of trials are adequate, per the recommendati ons of D381810 (S. Funk, 01/30/2011). E ach field trial included one control plot and one treated plot. At each site, the treated plot received two foliar broadcast application s of a 1.67 lb ai/gal (200 g ai/L) suspension concentrate (SC) formulation of chlorantraniliprole ( DPX - E2Y45 20SC) at 0.099 - 0.102 lb ai/A/application (111 - 115 g ai/ha/application) for a total rate of 0.200 - 0.203 lb ai/A (224 - 228 g ai/ha) . Applications were made with a 5 - or 6 - day retreatment interval (RTI) , starting 6 - 7 days prior to harvest . Applications were made using ground equipment in a spray volume of 13 - 25 gal/A (117 - 234 L/ha) ; an adjuvant was added to the spray mixture. Samples of peanuts were harvestedChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 21 of 44 1 day after the last application of chlorantranilipro le. Peanut forage/hay was not collected, but alfalfa may

be translated to cover peanut hay (S. Funk, D381810, 01/30.2011). Samples of peanut nutmeats were anal yz ed for residues of chlorantraniliprole using LC/MS/MS method. The limit of quantitation (L OQ) , based on the lowest level of method validation (LLMV) was 0.01 ppm for chlorantraniliprole in/on peanut nutmeats . The method was adequate for data collection based on acceptable method validation an d concurrent recoveries. The fortification levels used for concurrent recoveries were adequate to bracket expected residue levels. Peanut samples were stored frozen at approximately

 2 0 °C from collection to extraction for up to 3. 3 months ; samples were anal yz ed 0 - 1 day s after extraction. Adequate storage s tability studies are available which demonstrate that residues of chlorantraniliprole are stable at approximately

 20  C for at least 24 months in diverse crops , including water- , oil - , protein - , and starch - containing commodities as represented by fruits, a fruiting vegetable, a root crop, a non oily grain, and an oilseed (DP# 336941, L . Cheng, 2/25/2008). These data are adequate to support the storage intervals and conditions of samples from the submitted field trial study . Following two foliar broadcast application s of a 1.67 lb ai/gal SC formulation of chlorantraniliprole at a total rate of 0.20 lb ai/A , residues (and per trial averages) of chlorantraniliprole were <0.01 (<LOQ) - 0.046 (<0.01 - 0.034) ppm in/on nutmeats harvested at a 1 - day PHI. Peanut hay was not collected or analyzed. Itwas previously decided that the results for alfalfa hay may be translated to peanut hay (D361791, D. Rate, 01/08/2010). Peanut and alfalfa have similar proposed use patterns except for the PHI ; a 0 - day PHI exists for alfalfa and a 1 - day PHI is proposed for peanuts. Residues on alfalfa hay ranged from 8.0 to 47 ppm from the foliar application of an SC formulation at a total application rate of 0.2 lb ai/acre (0.1 lb ai/acre X 2) and a 0 - day

PHI . Rice 48930701. der DuPont has submitted field trial data for chlorantraniliprole on rice and crayfish. A total of 3 crop field trials were conducted during the 2011 growing season in NAFTA Growing Zone 4 (LA, 2 trials; MO, 1 trial). The number and distribution of trial s meet the conditions set in D361791 (D. Rate, 01/08/2010). The trials were requested to confirm the tolerance of 0.15 ppm set for rice based on exaggerated (4X) field trials with chlorantraniliprole. Each field trial included one control plot and one treated plot. Seeds for each treated plot received one seed treatment of an undiluted 5.21 lb ai/gal flowable concentrate (FS) formulation of chlorantraniliprole (DPX - E2Y45 - 456) at a rate of 0.204 lb ai/100 lb seed. Based on seeding rates, the field appli cation rate was 0.08 lb ai/A (90 g ai/ha). Seeds were planted 103 - 113 day s after they had been treated. Mature rice was harvested 231 - 238 day s after treatment, which was 118 - 135 day s after planting.Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 22 of 44 Samples of rice grain were anal yz ed for residues of chlorantraniliprole using LC/MS/MS methods, which was modified from Method DuPont - 13294 (for rice grain). The limit of quantitation (L OQs), based on the lowest levels of method validation (LLMVs), was 0.010 ppm for chlorantraniliprole in/on rice grain . Th e method is adequate for data collection based on acceptable concurrent recoveries. The fortification levels used for concurrent recoveries were adequate to bracket expected residue levels. Rice grain samples were stored frozen at approximately - 20 °C fro m harvest to extraction for up to 3.2 months ; samples were anal yz ed 1 - 8 day s after extraction. Adequate storage stability studies are available which demonstrate that residues of chlorantraniliprole are stable at approximately - 20  C for at least 24 months in diverse crops, including water - , oil - , protein - , and starch - containing commodities as represented by fruits, a fruiting vegetable, a root crop, a non oily grain, and an oilseed (DP# 336941, L . Cheng, 2/25/2008). These data are adequate to support the storage intervals and conditions of samples from the submitted field trial study . Following a single treatment of rice seed with a 5.21 lb ai/gal FS formulation of chlorantraniliprole at a rate of 0.204 lb ai/100 lb seed (equivalent to 0.08 lb ai/A), res idues (and per trial averages) of chlorantraniliprole were <0.010 - 0.016 (<0.010 - 0.015) ppm in/on rice grain harvested 118 - 135 day s after planting. Strawberry 48930708.der DuPont has submitted field trial data for chlorantraniliprole on strawberries. A total of 8 crop field trials were conducted during the 2011 growing season in NAFTA Growing Zones 1 (NY), 2 (GA), 3 (FL), 5 (IA and MN, 1 trial each), 10 (CA, 2 trials), and 12 (BC). The number and distribution of trials meets the requirements of OCSPP 860 .1500 and also fulfills the requests for confirmatory

trials for strawberry

(D361791, D. Rate, 01/08/2010). There is an existing tolerance of 1.0 pm for berry , low growing, subgroup 13 - 07G. Each field trial included one control plot and one treated plot. The treated plot received two foliar broadcast applications of a 1.67 lb ai/gal (200 g ai/L) suspension concentrate (SC) formulation of chlorantraniliprole (Chlorantraniliprole 20SC) at 0.09 7 - 0.106 lb ai/A/application (109 - 119 g ai/ha/application) for a total rate of 0.19 - 0.21 lb ai/A (217 - 235 g ai/ha). Applications were made with a 6 - to 7 - day retreatment interval (RTI), beginning 7 or 8 day s prior to harvest. Applications were made using ground equipment in a spray volume of 14 - 50 gal/A (131 - 466 L/ha); an adjuvant was added to the spray mixture. Mature fruit was harvested 1 day after the last application of chlorantraniliprole. Samples were anal yz ed for residues of chlorantraniliprole us ing a liquid chromatography/tandem mass spectrometry

(LC/MS/MS) method, modified Method DuPont - 13294. The limit of quantitation (L OQ), based on the lowest level of method validation (LLMV), was 0.010 ppm for chlorantraniliprole in/on strawberries. The method was adequate for data collection based on acceptable method validation and concurrent recoveries. The fortification levels used for concurrent recoveries were adequate to b racket expected residue levels. Strawberries were stored frozen at approximat ely - 20 °C from harvest to extraction for up to 6.8Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 23 of 44 months; samples were analyzed 1 - 4 day s after extraction. Adequate storage stability studies are available which demonstrate that residues of chlorantraniliprole are stable at approximately - 20  C for at least 24 months in diverse crops, including water- , oil - , protein - , and starch - containing commodities as represented by fruits, a fruiting vegetable, a root crop, a non - oily grain, and an oilseed (DP# 336941, L. Cheng, 2/25/2008). These data are adequate to support the storage intervals and conditions of samples from the submitted field trial study . Following two foliar broadcast applications of a 1.67 lb ai/gal SC formulation of chlorantraniliprole at a total rate of 0.2 lb ai/A, residues (and per trial averages) of chlorantraniliprole were 0.18 - 0.69 (0.18 - 0.68) ppm in/on strawberries harvested at a 1 - day PHI. Coffee 4930707.der DuPont has submitted field trial data for chlorantraniliprole on coffee. One coffee trial was conducted in the United States in Growing Zone 13 (HI) during the 2011 growing season. The trial fulfills the requests for confirmatory data for coffee (D361791, D. Rate, 01/08/2010). A trial in region 13 was requested to meet the requirement of five trials. Also, the use of adjuvant was requested. There is an existing tolerance of 0.4 ppm for coffee green beans. The field trial included one control plot and one treated plot. The treated plot received two foliar broadcast applications of a 35% (w/w) water- dispersible granule (WG) f ormulation of chlorantraniliprole (DPX - E2Y45 - 436) at 0.01 lb ai/A/application (111 - 112 g ai/ha/application) for a total rate of 0.2 lb ai/A (223 g ai/ha). Applications were made with a 14 - day retreatment interval (RTI), starting 21 day s prior to harvest. Applications were made using ground equipment in a spray

volume of 57.1 - 57.4 gal/A (534 - 537 L/ha); an adjuvant was added to the spray mixture. Samples of mature coffee cherries were harvested 7 day s after the last application of chlorantraniliprole, and coffee beans were collected 7 day s later following the standard procedure for producing beans from cherries. Samples were anal yz ed for residues of chlorantraniliprole using a LC/MS/MS method, modified Method DuPont - 13294. The limit of quantitation (LOQ), based on the lowest level of method validation (LLMV), was 0.010 ppm for chlorantraniliprole in/on coffee beans. The method was adequate for data collection based on acceptable concurrent recoveries. The fortification levels used for concurrent recoveri es were adequate to bracket expected residue levels. Coffee green bean samples were stored frozen at approximately - 20 °C from collection to extraction for 0.7 month; samples were anal yz ed 0 - 1 day s after extraction. Adequate storage stability studies are available which demonstrate that residues of chlorantraniliprole are stable at approximately - 20  C for at least 24 months in diverse crops, including water- , oil - , protein - , and starch - containing commodities as represented by fruits, a fruiting vegetable , a root crop, a non oily grain, and an oilseed (DP# 336941, L . Cheng, 2/25/2008). These data are adequate to support the storage intervals and conditions of samples from the submitted field trial study . Following two foliar broadcast applications of a 3 5% WG formulation of chlorantraniliprole at a total rate of 0.2 lb ai/A, residues of chlorantraniliprole were <0.010 ppm in/on coffee green beansChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 24 of 44 produced from coffee cherries harvested at a 7 - day PHI . Cucumber 49076101 .der IR - 4 has submitted greenhouse trial data for chlorantraniliprole on cucumber . Three greenhouse trials were conducted in the United States during the 2008 growing season in the NAFTA Growing Zones 2 (MD; 1 trial), 3 (FL; 1 trial), and 9 (CO; 1 trial). The number of trials is in accordance with recommendations of ChemSAC for greenhouse use where a field use exists with the same use rate and PHI (ChemSAC Minutes, 09/24/2008). Each trial consisted of one untreated plot and one treated plot. The cucumbers were grown in pots or in rockwo ol cubes. At each trial location, the treated plot received two foliar directed applications of a 1.67 lb ai/gal suspension concentrate (SC) formulation of chlorantraniliprole ( Coragen® 20SC ) at 0.098 - 0.122 lb ai/A/application for a total seasonal rate of 0.197 - 0.229 lb ai/A. Applications were made at a 3 - day retreatment interval (RTI) using ground equipment in spray volumes of 35.7 - 50.2 gal/A with a nonionic surfactant (NIS) or a nonionic surfactant/ organosilicone surfactant (NI S/OSS) included in each s pray mix. Samples of mature cucumbers were harvested at a preharvest interval (PHI) of 1 day . S amples were anal yz ed for residues of chlorantraniliprole using a LC/MS/MS method based on DuPont - 13294. The limit of quantitation (L OQ; determined as the lo west level of method validation, LLMV) was 0.01 ppm in/on cucumbers. The method was adequate for data collection based on acceptable method validation and concurrent recovery data. The fortification levels used in method validation and concurrent method recovery were adequate to bracket expected residue levels. Recoveries and residues in treated samples were not corrected for residues in controls. Samples were stored frozen ( - 37 to - 0.2 °C) from collection to anal ys is for 525 - 562 day s (17.3 - 18.5 months) . Samples were anal yz ed on the day of extraction. To support the sample storage intervals, a concurrent storage stability study was conducted with the greenhouse study . The data demonstrate that residues of chlorantraniliprole were stable in/on cucumbers stored frozen for up to 572 day s (18.8 months); no 0 - day data were provided. HED has concluded (see minutes of 6/19/13 Chemistry Science Advisory

Council (ChemSAC) meeting) that 0 - day fortified samples are desirable for storage stability study but are n ot mandatory . Following two foliar directed applications of the 1.67 lb ai/gal SC formulation of chlorantraniliprole at a total rate of 0.19 7 - 0.2 29 lb ai/A, residues of chlorantraniliprole (and per trial averages) in/on cucumbers harvested at a 1 - day PH I were 0.0210 - 0.0738 ( 0.0257 - 0.0697 ) ppm . Tomato 49076102.der IR - 4 has submitted greenhouse trial data for chlorantraniliprole on tomato . Four greenhouse trials were conducted in the United States during the 2007 growing season in the NAFTA Growing Zones 2 (NJ and TN; 2 trials), 6 (TX; 1 trial), and 9 (CO; 1 trial). The number of trialsChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 25 of 44 is in accordance with recommendations of ChemSAC for greenhouse use where a field use exists with the same use rate and PHI(ChemSAC Minutes, 09/24/2008). Each trial consisted of one untreated plot and one treated plot. At each trial location, the treated plot received two foliar directed applications of a 1.67 lb ai/gal suspension concentrate (SC) formulation of chlorantraniliprole ( Coragen® 20SC ) at 0.099 - 0.106 lb ai/A/application for a total seasonal rate of 0.199 - 0.209 lb ai/A. Applications were made at a 4 - to 6 - day retreatment interval (RTI) using ground equipment in spray volumes of 50 - 94 gal/A. Adjuvants were not added to the spray

mix. Samples of mature tomatoes were harvested at a preharvest interval (PHI) of 1 day . S amples were anal yz ed for residues of chlorantraniliprole using a LC/MS/MS method based on DuPont - 13294. The limit of quantitation (L OQ; determined as the lowest level of method v alidation, LLMV) was 0.01 ppm in/on tomatoes. The method was adequate for data collection based on acceptable method validation and concurrent recovery data. The fortification levels used in method validation and concurrent method recovery were adequate to bracket expected residue levels. Recoveries and residues in treated samples were not corrected for residues in controls. Samples were stored frozen ( - 37 to - 2 °C) from collection to analy sis for 77 - 229 day s (2.5 - 7.5 months). Samples were anal yz ed within 0 - 2 day s of extraction. To support the sample storage intervals, a concurrent storage stability study was conducted with the greenhouse study . The data demonstrate that residues of chlorantraniliprole were stable in/on tomatoes stored frozen for up t o 235 day s (7.7 months); no 0 - day data were provided. HED has concluded (see minutes of 6/19/13 Chemistry

Science Advisory

Council (ChemSAC) meeting) that 0 - day fortified samples are desirable for storage stability study but are not mandatory . Following two foliar directed applications of the 1.67 lb ai/gal SC formulation of chlorantraniliprole at a total rate of 0.19 9 - 0.2 09 lb ai/A, residues of chlorantraniliprole (and per trial averages) in/on tomatoes harvested at a 1 - day PHIwere 0.0101 - 0.102 ( 0.0126 - 0.0963 ) ppm . Cherry , Papaya , Lychee 49076103.der Conditional registrations for the use of chlorantraniliprole on tropical fruit crops were established. A tolerance of 4.0 ppm for larger, slow - growing tropical fruits and a tolerance of 2.0 ppm for smaller, fast - growing tropical fruits were established. The tolerances for tropical fruit are based on the translation of stone fruit data (D361791, D. Rate, 01/08/2010 ; ChemSAC Minutes 10/01/2008 and 11/17/2008 ). Residue decline studies were requested for cherry , lychee, and papaya. IR - 4 has submitted residue decline field trial data for chlorantraniliprole on cherries, lychee, and papaya . Three field trials were conducted in the United States during the 2009 growing season. One cherry

trial was conducted in NAFTA Growing Zone 11 (WA; 1 trial); one lychee trial was conducted in Zone 13 (FL; 1 trial); and one papaya trial was conducted in Zone 13 (HI; 1 trial). Each trial consisted of one untreated plot and one treated plot. At each trial location, the treatedChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 26 of 44 plot received two foliar directed applications of a 35% water dispersible granule (WG) formulation of chlorantraniliprole (Altacor® ) at 0.099 - 0.105 lb ai/A/application for a total seasonal rate of 0.199 - 0.207 lb ai/A. Applications were made at a 9 - to 10 - day retreatment interval (RTI) using ground equipment in spray volumes of 76 - 198 gal/A with an nonionic surfactant (NIS) included in each spray mix. Samples of mature fruit were harvested at preharvest intervals (PHIs) of 1, 3, 6/7, 9/10, and 13/14/15 day s. S amples were anal yz ed for residues of chlorantraniliprole using a L C/MS/MS method based on DuPont - 13294. The limit of quantitation (L OQ; determined as the lowest level of method validation, LLMV) was 0.01 ppm in/on cherries, lychee, and papaya. The method was adequate for data collection based on acceptable method validation and concurrent recovery data. The fortification levels used in method validation and concurrent method recovery were adequate to bracket expected residue levels. Recoveries and residues in treated samples were not corrected for residues in controls. Samples were stored frozen ( - 37 to - 0.6 °C) from collection to anal ys is for 712 - 726 day s (23.4 - 23.9 months) for cherries, 713 - 725 day s (23.5 - 23.8 months) for lychee, and 710 - 723 day s (23.4 - 23.8 months) for papaya. Samples were anal yz ed within 1 - 9 day s of extraction. To support the sample storage intervals, a concurrent storage stability study was conducted with the field trial study . The data demonstrate that residues of chlorantraniliprole were stable in/on cherries stored frozen for up to 802 day s (26. 4 months); no 0 - day data were provided. HED has concluded (see minutes of 6/19/13 Chemistry Science Advisory

Council (ChemSAC) meeting) that 0 - day recovery data for fortified samples are desirable for storage stability studies but are not mandatory . Fo llowing two foliar directed applications of the 35% WG formulation of chlorantraniliprole at a total rate of 0.199 lb ai/A, residues of chlorantraniliprole (and per trial averages) in/on cherries harvested at 1 - , 3 - , 6 - , 10 - , and 15 - day PHI s, respectively , were: 0.151 - 0.192 (0.171), 0.135 - 0.162 (0.148), 0.105 - 0.120 (0.112), 0.132 - 0.151 (0.141), and 0.0994 - 0.129 (0.114) ppm. Following two foliar directed applications of the 35% WG formulation of chlorantraniliprole at a total rate of 0.200 lb ai/A, residu es of chlorantraniliprole (and per trial averages) in/on lychee harvested at 1 - , 3 - , 6 - , 9 - , and 13 - day PHIs, respectively , were: 0.402 - 0.500 (0.451), 0.306 - 0.442 (0.374), 0.363 - 0.386 (0.374), 0.239 - 0.313 (0.276), and 0.308 - 0.337 (0.322) ppm. Following two foliar directed applications of the 35% WG formulation of chlorantraniliprole at a total rate of 0.207 lb ai/A, residues of chlorantraniliprole (and per trial averages) in/on papaya harvested at 1 - , 3 - , 7 - , 10 - , and 14 - day PHI s, respectively , were: 0.28 4 - 0.292 (0.288), 0.204 - 0.224 (0.214), 0.196 - 0.211 (0.203), 0.164 - 0.196 (0.180), and 0.137 - 0.142 (0.139) ppm. The half - lives were calculated based on the assumption of first order kinetics and a slope m determined b y least squares straight line fit of ln average concentration versus time (day s); t 1/2 = ln 2/m for all sampling intervals. The half - lives ranged from 14 to 32 day s. These results confirm that very

small fruit (cherry) and tropical fruits have approximately the same half

- lives as stone fruits (median 33, minimum 19 days) and pome fruits (median 23, minimum 11 days) (D361791, D. Rate, 01/08/2010; ChemSAC Minutes 10/01/2008 and 11/17/2008) . ThisChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 27 of 44 validates the previous decision to translate the stone fruit tolerance to tropical fruits and to red uce the PHI for some tropical fruits from 10 day s to 1 day with a 2x correction applied to the stone fruit tolerance. The half - lives show that residues will not exceed a doubling (2x) with a reduction from 10 day s to 1 day in the PHI. Therefore, the proposal to reduce the PHI for papaya and passionfruit from 10 day s to 1 day with an increase in the tolerances from 2 ppm to 4 ppm is acceptable. **T able**  **5.3.1.1 Residue Data from** **Cherry, Lychee, and Papaya Field Trials with Chlorantraniliprole**  **.**

Trial ID (City, State, Province; Year) Zone Crop; Variety Commodity Total Rate (lb ai/A) PHI

(days) Residues Chlorantraniliprole

(ppm) [Average] 1 **Cherry Trials** Prosser, WA; 2009 (WA03) 11 Cherry; Sweetheart Fruit 0.199 1 0.151, 0.192 [0.171] 3 0.135, 0.162 [0.148] 6 0.105, 0.120 [0.112] 10 0.151, 0.132 [0.141] 15 0.129, 0.0994 [0.114] Half life 1 31 days

**Lychee Trials** Homestead, FL ; 2009 (FL69 ) 13 Lychee; Brewster Fruit 0.200 1 0.402, 0.500 [0.451] 3 0.306, 0.442 [0.374] 6 0.386, 0.363 [0.374] 9 0.313, 0.239 [0.276] 13 0.337, 0.308 [0.322] Half life 1 32 days

**Papaya Trials** Hilo, HI ; 2009 ( HI01 ) 13 Papaya; Rainbow Fruit 0.207 1 0.292, 0.284 [0.288] 3 0.204, 0.224 [0.214] 7 0.211, 0.196 [0.203] 10 0.196, 0.164 [0.180] 14 0.137, 0.142 [0.139] Half life 1 14 days 1 Assumes first order kinetics and a slope m determined by least squares straight line fit of ln average concentration versus time (days); t 1/2 = ln 2/m. **Table 5.3.1.2**  **. Summ ary of Residues from** **Field Trials with Chlorantraniliprole**  Crop Matrix Analyte Applic.

Rate (lb ai/acre) PHI

(days) n * Residues (ppm)

Min. † Max. † LAFT * HAFT ***** Median ***** Mean ***** SD ***** Peanut Proposed Use = 0.2 0 lb ai/acre total application rate . 1 day PHI Nutmeat Chlor antra niliprole 0.20 1 6 <0.01 0046 <0.01 0.034 0.01 0.014 0.010 Rice Proposed Use = 0.08 lb ai/acre total application rate, at -plant applicationChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 28 of 44 Grain Chlor antra niliprole 0.08 125 -

135 3 < 0.010 0.016 <0.010 0.015 0.012 0.012 0.02 Berry , low

growing, subgroup 13 - 07G . Proposed Use = 0.20 lb ai/acre total application rate . 1 day PHI Straw berry fruit Chlor antra niliprole 0.2 1 8 0.18 0.69 0.18 0.68 0.23 0.30 0.17 Coffee. Proposed Use = 0.20 lb ai/acre total application rate. 7 day PHI Coffee green bean Chlor antra niliprole 0.2 7 1 <0.01 0 <0.01 0 < 0.01 0 < 0.01 0 0.01 0.01 NA Cucumber. Proposed Use = =0.20 lb ai/acre total application rate in greenhouse. 1 day PHI Cucumber fruit Chlor antra niliprole 0.20 - 0.23 1 3 0.0210 0.0738 0.0257 0.0697 0.0296 0.0417 0.0244 Tomato. Proposed Use =0.20 lb ai/acre total application rate in greenhouse. 1 day PHI Tomato fruit Chlor antra niliprole 0.20 - 0.21 1 4 0.0101 0.102 0.0126 0.0963 0.0314 0.0429 0.0378 Onion, green, subgroup 3 - 07B. Proposed use = 0.20 lb ai/acre total application rate per crop. 1 day PHI Green onion Chlor antra niliprole 0.20 1 5 0.371 1.50 0.406 1.49 0.717 0.811 0.406 Green onion, dry Chlor antra niliprole 0.20 1 5 0.900 11.1 1.00 10.8 2.66 4.44 4.11 Dill seed. Proposed Use = Dill seed Chlor antra niliprole 0.20 1 2 15.4 24.3 17.0 19.8 18.4 18.4 N/A † Values based on total number of samples. * Values based on per - trial averages. LAFT = Lowest Average Field Trial, HAFT = Highest Average Field Trial, SD = Standard Deviation. For computation of the LAFT, HAFT, median, mean, and standard deviation, values < LOQ are assumed to be at the LOQ. Conclusions . The greenhouse tomato trials are adequate to cover the use on fruiting vegetables in greenhouses, per the decision of ChemSAC (Minutes of the ChemSAC Meeting, 09/29/2010). The greenhouse cucumber trials are adequate to cover the use on cucumber grown in greenhouses. In both instances, the existing tolerances will encompass the expanded use (See 6.0). The strawberry

field trials were conducted according to the label for crop subgroup 13 - 07G. The existing tolerance for this subgroup will enc ompass the use on strawberry (See 6.0). The data fulfill the condition or registration requirement for strawberry ( D361791, D. Rate, 01/08/2010). The peanut field trials provide adequate data to support a tolerance on peanut nutmeat. The number and distribution of trials are adequate, per the recommendations of D381810 (S. Funk, 01/30/2011). Alfalfa hay results may be translate d to peanut nutmeat. The rice seed treatment trials are adequate to confirm the existing tolerance and fulfill a condition of registration requirement (D316791, D. Rate, 01/08/2010). See 6.0.Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 29 of 44 The single residue decline studies on cherry , papaya, and l ychee completes the condition of registration data requirement for decline data on (tropical) fruits of small and large size (D316791, D. Rate, 01/08/2010). The request to decrease the PHI for papaya and passionfruit from 10 day s to 1 day with increases in the tolerances from 2 ppm to 4 ppm is acceptable. **5.3.2 Field**  **Rotational Crops (860.1900 )**  DP#404708, S. Funk, 09/10/2013 ( PP#2E8064) DP#382293, S. Funk, 02/28/2011 (PP#0F7763) DP#353542, L. Cheng, 6/18/2008 (PP#7F7181) DP#336941, L. Cheng, 2/25/2008 (PP#7F7181) Minutes of the April 9, 2008 Meeting of the HED Chemistry SAC ( ChemSAC min_388.4 - 9 - 08) DP#361791, D. Rate, 01/08/201 0 (PP#9F7513) DP#384485, D. Rate, 12/01/2010 Chlorantraniliprole is the major residue in all rotational crop commodities studied. No new field rotational crop data were presented Acceptable studies pertaining to limited field accumulation in rotational crops were reviewed in PP# 7F7181 (DP#353542, L . Cheng, 6/18/2008) . HED concluded that these data are adequate for estimation of the magnitude of residues of chlorantraniliprole in root, leafy , and cereal grain crops when grown rotationally in fields previously

treated with chlorantraniliprole at total seasonal rates of 0.9 - 2.7x. Generally , residues at or above the LOQ (0.010 ppm) may occur on rotated leafy

crops and on the tops of root vegetables at plantback intervals of 30 - 130 day s, ranging between 0.01 and 0.2 ppm, whereas residues on grain and root vegetables are anticipated to be below the LOQ. Chlorantraniliprole residues ( > 0.01 ppm) are also possible in livestock feedstuffs o f rotated grain crops (forage, straw, hay), ranging from 0.02 to 0.2 ppm for plantback intervals (PBIs) ranging from 30 - 240 day s. These data suggested that rotational crop tolerances are required , and that the petitioner needs to conduct extensive field rotational crop trials. HED previously

concluded that until the requested data are submitted, a restriction should be imposed on the proposed labels to prohibit the rotation to any crop not on the label (DP#336941, L . Cheng, 2/25/2008). The petitioner sub sequently submitted proposals and justification requesting no rotational crop restrictions for chlorantraniliprole and for the establishment of tolerances for inadvertent residues for a number of crops. The submission was brought to HED’s ChemSAC for disc ussion on April 9, 2008. Based on the available data, the ChemSAC determined that a 30 - day plant - back interval is appropriate for all crops requested (bulb vegetables, peanuts, sugar cane, asparagus, okra, strawberry , crop groups 6, 15, 16, 17, 18) excep t Crop Groups 1 and 2, for which a 0 - day PBI is allowable. Time - limited tolerances, with expiration date of 4/10/14, were previou sl y established for indirect or inadvertent residues of chlorantraniliprole in/on: cereal grain forage, fodder and straw ( Crop Group 16) at 0.20 ppm; leek at 0.20 ppm; green onion at 0.20 ppm; Welsh onion at 0.20 ppm; peanut hay

at 0.20 ppm; and shallot fresh leaves at 0.20 ppm . These have been recommended for removal upon relevant primary crop (crop group) tolerances.Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 30 of 44 Subs equently

the addition of the following oilseed rotational crops with a reduction of the PBI from 12 mo nths to 30 day s was made (D3844 85, D. Rate, 12/01/2010): borage, calendula, castor oil plant, Chinese tallowtree, cuphea, echium euphorbia, evening primro se, flax, gold of pleasure, meadowfoam, niger seed, safflower, stokes aster, sunflower, sweet rocket, and veronica. The 30 - day

PBI was subsequentl y extrapolated to all rotated oilseeds, based on rotated cereal grain and soy

bean seed data (D397571, S.Funk, 05/01/2012). Conclusions . Adequate field rotational crop studies have been conducted previousl y to support appropriate plant - back intervals for those crops with no primary uses. Additi onal data are not required. **5.3.3 Processed Food and Feed (860.1**  **520)** No new processing studies were provided. Peanuts in the only commodity addressed herein for which the required processing study has not been conducted/reviewed . DuPont previously requested a waiver from the peanut processing study based on a trans lation of the results of the cottonseed processing study (D382293, S. Funk, 02/30/2011). Inthe cottonseed processing study (MRID 46979734) , delinted cottonseed was mechanically cracked and the hulls separated from the kernels. The kernels were dried to 12% moisture content , heated, flaked, and expanded/extruded under steam to collets. The collets are extracted with solvent (hexane). The miscella (c rude oil and hexane) is separated, the crude oil is heated to remove residual hexane, and the oil is refined b y alkali treatment. A very similar commercial process is used with peanuts, although as a first step peanuts may be subjected to mechanical press ure to remove some oil. The resulting press cake is extracted with hexane, and the oil fractions are combined and purified with alkali treatment. Inthe cotton processing study , average residues of chlorantraniliprole were 0.016 ppm in cotton seed har vested 21 day s after treatment with the 35WG at a total rate of 0.40 lb ai/A. Average residues after processing were 0.004, 0.012 and 0.033 ppm in refined oil, meal and hulls, respectivel y . The results of the cotton processing study show that chlorantrani liprole upon processing does not concentrate in refined oil (0.25x) or meal (0.75x) but concentrates in hulls (2.1x) (D3369 41, LCheng, 02/25/2008). The oil content of peanuts is 45

– 52% (Agricultural Marketing Resource Center, Iowa State University). The oil content of cottonseed is 18

– 26% (Table 4, OECD Guidance Document on Magnitude of the Pesticide Residues in Processed Commodities , ENV/JM/MONO(2008)23, 07/29 /2008). As the commercial processing procedures for cottonseed and peanut are similar and peanut yi elds more oil than cottonseed for a given weight of commodity, the cottonseed processing results may

be translated to peanut. Concentration of chlorantraniliprole will not occur in peanut oil (0.25x) or peanut meal (0.75x). Conclusions: The cottonseed processing study may be translated to peanuts. Concentration of chlorantraniliprole from peanut to oil is not anticipated. The concentration/reduction factors areChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 31 of 44 0.25x for peanut oil and 0.75x for peanut meal. **5.3.4 Meat, Milk, Poultry a**  **nd Eggs (860.1480)**  An acceptable ruminant feeding study (MRID 46895504) was previously submitted in connection with PP#7F7181 (DP#336941, L . Cheng , 2/25/20 08) . An acceptable poultry feeding study was previously

submitted (D404708, S. Funk, 09/10/2013) No new feeding study data were submitted. **5.3. 4.1**  **Dietary Burden** Peanut meal and peanut hay are the only

new feed item associated with the current submissions. Peanut meal is a protein concentrate fed to dairy cattle (10%), poultry

(25%), and swine (15%). Peanut hay

is a roughage fed only

to dairy cattle (15%). The dietary burdens (D404708, S.Funk, 09/10/2013) will not change as a result of these new feeds. O ther feed items already considered contribute more to the total dietary burden. **5 .3.**  **4.2 Estimated Secondary Residues in Livestock**  The estimated secondary

residue in livestock remain unchanged from the latest calculation (D404708, S.Funk, 09/10/2013). Conclusions: The dietary

burdens of poultry , swine, and ruminants remain unchanged. The existing tolerances for meat, milk, poultry , and eggs are adequate. **5.3. 5**  **. Food Handling (860.1460)**  There are no food handling uses related to the current submissi ons. **5.3. 6**  **Water, Fish, and Irrigated Crops (860.1400)** 48930701.der Crayfish DuPont has submitted field trial data for chlorantraniliprole on rice and crayfish. A total of 3 crop field trials were conducted during the 2011 growing season in North Atlantic Free Trade Agreement (NAFTA) Growing Zone 4 (LA, 2 trials; MO, 1 trial). A previous request to waive the study was denied (D361791, D. Rate, 01/08/20100. Each field trial included one control plot and one treated plot. Seeds for each treated pl ot received one seed treatment of an undiluted 5.21 lb ai/gal flowable concentrate (FS) formulation of chlorantraniliprole (DPX - E2Y45 - 456) at a rate of 0.204 lb ai/100 lb seed. Based on seeding rates, the field application rate was 0.08 lb ai/A (90 g ai/h a). Seeds were planted 103 - 113 day s after they had been treated. Mature rice was harvested 231 - 238 day s after treatment, which was 118 - 135 day s after planting. Crayfish were collected from the plots, when possible, at theChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 32 of 44 following intervals after planting rice: 51 - 52 day s (earl y first season), 76 - 77 day s (mid first season), 103 day s (late first season), and 279 or 318 day s (normal harvest). Samples of crayfish were anal yz ed for residues of chlorantraniliprole and its metabolite IN ECD73 (in crayfish o nl y) a using a LC /MS/MS method, which was modified from Method DuPont - 24137 (for crayfish). The limits of quantitation (LOQs), based on the lowest levels of method validation (LLMVs), were 0.010 ppm for chlorantraniliprole in crayfish and 0.010 ppm for IN - ECD73 in crayfish. The fortification levels used for concurrent recoveries were adequate to bracket expected residue levels. Crayfish samples were stored frozen at approximately - 20 °C from harvest to extraction for up to 9.9 months; samples were anal yz ed 1 - 8 day s after extraction. Storage stability data generated concurrently

with the field trial study

demonstrate that residues of chlorantraniliprole and IN ECD73 were stable in/on crayfish for up to 10 months of frozen storage. These data are adequate to support the storage intervals and conditions of samples from the submitted trial study . Following a single treatment of rice seed with a 5.21 lb ai/gal FS formulation of chlorantraniliprole at a rate of 0.204 lb ai/100 lb seed (equivalent to 0.08 lb ai/A), residues (and per trial averages) of chlorantraniliprole and IN - ECD73 were all below the L OQ (<0.010 ppm each) in/on all samples of crayfish collected 51 - 52, 76 - 87, 103 - 122, and 279 - 318 day s after rice was planted. Conclusions The rice seed treatment reflects the proposed maximum application rate. Adequate concurrent storage stability

data were presented to support the residue data, and an adequate data collection anal ytical method was utilized. The lack of residues (<0.01 ppm chlorantraniliprole) in crayfish at sampling intervals of 51 to 318 day s after rice planting shows no bioaccumulation of chorantraniliprole . The existing tolerance of 8.0 ppm may be reduced to 0.01 ppm. **6.0 Tolerance**  **Derivation** Tolerance estimates for rice grain (3 trials), peanut (6 trials), strawberry (8 trials), coffee green beans (5 trials), greenhouse cucumber (5 trials), greenhouse tomato (4 trials), and green onions (5 trials) were made b y use of the OECD tolerance calculation procedures. The st atistical goal of the tolerance calculation procedures is to produce an MRLproposal in the region of the 95 th percentile of the underl yi ng residues distribution. The existing tolerance s for rice grain, strawberry

(berry low growing subgroup 13 - 07H), coff ee green beans, cucurbit vegetables group 9, and fruiting veget ables group 8 - 10 were confirmed , that is, the tolerance estimates obtained from the new field trial data sets were the same as or lower than the existing tolerances. The tolerance estimate for peanut nutmeats was 0.06 ppm. No anal ys es were conducted for peanut hay , but it was previously decided ( D361791, D. Rate, 01/08/2010). that alfalfa hay may be translated to peanut hay . The animal feed nongrass group 18 (including alfalfa) hay tolerance is 90 ppm.Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 33 of 44 The green onion tolerance estimate of 3.0 ppm may be used for the onion, green, subgroup 3 - 07B. The conversion of green onions to dried onions has an median processing factor of 3.4 . That factor applied to the green onion highest field trial residue , 1.49 ppm , yields a tolerance estimate of 5 ppm for dried onions. The dried onion may be used as a surrogate for dried chive, a representative commodity of crop subgroup 19A. The existing tolerance for the herb subgroup 19A is 90 ppm, and is based on the extrapolation of alfalfa hay to dried basil. The 90 ppm will be retained, as it represents possible residue levels in dried basil, the other representative commodity

for subgroup 19A. Two dill seed trials were conducted. Where onl y two trials are conducted, the OECD calculation spreadsheet is not applicable. The residue estimate is taken as 5 X mean, or 5 X 19.4. The tolerance estimate for the spices subgroup 19B is 90 ppm. This rep laces the existing estimate of 14.0 ppm (D361791, D. Rate, 01/08/2010). Note that the registrant petitioned for 40 ppm. The crayfish study

(n = 3 trials) included samples taken from 50

– 318 day s after planting of treated rice seeds. All samples of crayfish contained no residues at the LOQ of 0.01 ppm . The existing tolerance of 8 ppm was based on the use of a fish bioconcentration study and the estimated residues in water, s ediment, and rice straw . Therefore, the tolerance may be lowered to 0.01 ppm. The tolerances for papaya and passion fruit will be increased from 2 ppm to 4 ppm. This reflects a requested decrease in the PHI from 10 day s to 1 day . The residue decline study with cher

ry , leechee, and papaya shows that the half - life is in excess of 10 day s and that, therefore, a doubling of the tolerance will be adequate (D361791, D. Rate, 01/08/2010).Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 34 of 44 **Appendix A**  **. International Residue Limits Table Table**  **A 1.**  **Summary of US and International Tolerances and Maxim um** **Residue Limits of**  **Chlorantrani liprole**  Residue Definition

US Canada Mexico b Codex 40CFR§180.628. For plant and animal commodities: chlorantraniliprole, 3 -bromo -N - [4 - chloro - 2 - methyl - 6 - [(methylamino)carbonyl]phenyl] - 1 - (3 - chloro - 2 - pyridinyl) - 1H -py

razole - 5 - carboxamide 3 -bromo - N - [ 4 - chloro - 2 - methyl - 6 - [(methylamino)carbo nyl]phenyl] - 1 - (3 - chloro - 2 -py

ridinyl) - 1H -py razole - 5 - carboxamide. Chlorantraniliprole (fat soluble) Commodity a Tolerance (ppm) /Maximum Residue Limit (mg/kg) US Canada Mexico b Codex Crayfish 0.01 None Fruit, pome, group 11 - 10 1.2 0.4 (listed as individual commodities: apple, etc) 0.4 Fruit, stone, group 12 - 12, except cherry, Chickasaw plum, and damson plum 4.0 2.5 (listed as individual commodities: peach, etc) 1

Nut, tree, group 14 - 12 0.02 0.02 (listed as individual commodities: almond, chestnut, etc ) 0.02 Papaya 4.0 None None Passionfruit 4.0 None None Peanut, nutmeat 0.06 0.06 (pending) None Peanut, hay 90 None None Onion, green, subgroup 3 - 07B 3.0 3.0 (pending) (listed as individual commodities: green onion, etc) None Spice subgroup 19B 90 None None Com pleted: 10/30/2013 a I ncludes only commodities of interest for this action. Tolerance values should be the HED recommendations and not those proposed by the applicant. b M exico adopts US tolerances and/or Codex MRLs for its export purposes.Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 35 of 44 **A ppendix**  **B .**  **OECD MRL Calculation Procedure Inputs/Outputs**  **Tree Nuts** Almond **Almond Chlorantraniliprole** 

**US GAP**  **Total number of data (n)** 6 **Percentage of censored data** 100% **Number of non -**  **censored data** 0 **Lowest residue** 0.010 **Highest residue** 0.010 **Median residue** 0.010 **Mean** 0.010 **Standard deviation (SD)** 0.000 **Correction factor for censoring (CF)** 0.333 **Proposed MRL estimate**

**- Highest residue**  0.010

**- Mean + 4**  **SD** 0.010

**- CF x 3 Mean**  0.010 **Unrounded MRL** 0.010 **Rounded MRL 0.01**  High uncertainty of MRL estimate. [Small dataset and high level of censoring] ‘ **Residues (mg/kg) n** 

< 0.01 6 Pecan **Chlorantraniliprole pecan**  **US GAP**  **Total number of data (n)**  6 **Percentage of censored data** 67% **Number of non -**  **censored data** 2 **Lowest residue** 0.010 **Highest residue** 0.015Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 36 of 44 **Median residue** 0.010 **Mean** 0.012 **Standard deviation (SD)** 0.002 **Correction factor for censoring (CF)** 0.556 **Proposed MRL estimate** 

**- Highest residue**  0.015

**- Mean + 4 SD**  0.021

**- CF x 3 Mean**  0.019 **Unrounded MRL** 0.021 **Rounded MRL 0.02**  High uncertainty of MRL estimate. [Small dataset and high level of censoring] **Residues (mg/kg) n**  < 0.01 4 0.014 1 0.015 1 **Rice** Three trials were conducted to confirm a 0.15 ppm tolerance on grain set from exaggerated (4X) trials. The existing tolerance for rice grain is 0.15 ppm. The estimate from the present three trials is 0.04 ppm. The tolerance is confirmed as adequate. **chlorantraniliprole**

**rice USA**  **seed treatment Total number of data (n)**  3 **Percentage of censored data** 0% **Number of non -**  **censored data** 3 **Lowest residue** 0.010 **Highest residue** 0.015 **Median residue** 0.012 **Mean** 0.012 **Standard deviation (SD)**  0.003 **Correction factor for censoring (CF)** 1.000 **Proposed MRL estimate**Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 37 of 44 **- Highest residue**  0.015

**- Mean + 4 SD**  0.022

**- CF x 3 Mean**  0.037 **Unrounded MRL** 0.037 **Rounded MRL 0.04**  High uncertainty of MRL estimate. [Small dataset] **Residues (mg/kg) n**  0.01 1 0.012 1 0.015 1Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 38 of 44 **Peanut Chlorantraniliprole**  **Peanut USA**  **2X0.1 lb ai/A, 1 d PHI Total number of data (n)**  6 **Percentage of censored data** 67% **Number of non -**  **censored data** 2 **Lowest residue** 0.010 **Highest residue** 0.034 **Median residue** 0.010 **Mean** 0.014 **Standard deviation (SD)** 0.010 **Correction factor for censoring (CF)** 0.556 **Proposed MRL estimate**

**- Highest residue**  0.034

**- Mean + 4 SD**  0.053

**- CF x 3 Mean**  0.024 **Unrounded MRL** 0.053 **Rounded MRL 0.06**  High uncertainty of MRL estimate. [Small dataset and high level of censoring] **Residues (mg/kg) n**  < 0.01 4 0.012 1 0.034 1Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 39 of 44 **Strawberry (Berry, low growing, subgroup 13**  **- 07G)**  **Chlorantraniliprole Strawberry**  **USA 2X**  **- 0.1 lb ai/A, 1 d PHI**  **Total number of data (n)** 8 **Percentage of censored data** 0% **Number of non -**  **censored data** 8 **Lowest residue** 0.180 **Highest residue** 0.680 **Median residue** 0.235 **Mean** 0.298 **Standard deviation (SD)** 0.169 **Correction factor for censoring (CF)**  1.000 **Proposed MRL estimate**

**- Highest residue**  0.680

**- Mean + 4 SD**  0.972

**- CF x 3 Mean**  0.893 **Unrounded MRL** 0.972 **Rounded MRL 1**  **Residues (mg/kg) n**  0.18 1 0.2 1 0.21 1 0.23 1 0.24 2 0.4 1 0.68 1Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 40 of 44 **Coffee Green Bean** The existing tolerance for coffee green beans is 0.4 ppm. An addition trial was conducted to assess the effect of adjuvant and to fulfill the requirement for five trials. The combined data yi elds a tolerance estimate of 0.4 ppm. This confirms the existing tolerance. The initial 4 trials were conducted at 0.7x the label rate (MRID 47588222). The residues were corrected to 1x by

the use of proportionality.

**Chlorantraniliprole Coffee**  **US 0.2 lb ai/acre, 7 d PHI**  **Total number of data (n)**  5 **Percentage of censored data** 20% **Number of non -**  **censored data** 4 **Lowest residue** 0.010 **Highest residue** 0.160 **Median residue** 0.140 **Mean** 0.122 **Standard deviation (SD)** 0.063 **Correction factor for censoring (CF)** 0.867 **Proposed MRL estimate** 

**- Highest residue**  0.160

**- Mean + 4 SD**  0.376

**- CF x 3 Mean**  0.317 **Unrounded MRL** 0.376 **Rounded MRL 0.4**  High uncertainty of MRL estimate. [Small dataset] **Residues (mg/kg) n**  < 0.01 1 0.14 1 2 0.16 1 2 1 Adjusted to 1x application rate.Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 41 of 44 **Cucumber (Gree n**  **house)** The tolerance estimate for cucumbers from greenhouse use is 0.15 ppm. The existing tolerance for vegetable, cucurbit, group 9 is 0.5 ppm, which i s within 5X of the estimate for greenhouse use on cucumber. **Chlorantraniliprole Cucumber (greenhouse)** 

**USA 0.2 lb ai/A, 1 d PHI**  **Total number of data (n)** 3 **Percentage of censored data** 0% **Number of non -**  **censored data** 3 **Lowest residue** 0.026 **Highest residue** 0.070 **Median residue** 0.030 **Mean** 0.042 **Standard deviation (SD)** 0.024 **Correction factor for censoring (CF)** 1.000 **Proposed MRL estimate**

**- Highest residue**  0.070

**- Mean + 4 SD**  0.139

**- CF x 3 Mean**  0.125 **Unrounded MRL** 0.139 **Rounded MRL 0.15**  High uncertainty of MRL estimate. [Small dataset] **Residues (mg/kg) n**  0.0257 1 0.0296 1 0.0697 1Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 42 of 44 **Tomato (Greenhouse)**  The tolerance estimate for tomato from greenhouse use is 0.20 ppm. The existing tolerance for vegetable, fruiting, group 8 - 10 is 1.4 ppm. The existing tolerance for the crop group is adequate for tomatoes from greenhouse use. While the existing tolerance is >5X from the new estimate, the existing tolerance also reflects the use of adjuvants. **Chlorantraniliprole Tomato (G**  **reenhouse)**

**USA 0.2 lb ai/A, 1 day PHI**  **Total number of data (n)** 4 **Percentage of censored data** 0% **Number of non -**  **censored data** 4 **Lowest residue** 0.013 **Highest residue** 0.096 **Median residue** 0.031 **Mean** 0.043 **Standard deviation (SD)** 0.038 **Correction factor for censoring (CF)** 1.000 **Proposed MRL estimate**

**- Highest residue**  0.096

**- Mean + 4 SD**  0.194

**- CF x 3 Mean**  0.129 **Unrounded MRL** 0.194 **Rounded MRL 0.2**  High uncertainty of MRL estimate. [Small dataset] **Residues (mg/kg)**  **n** 0.0126 1 0.0203 1 0.0424 1 0.0963 1Chlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 43 of 44 **Green Onion Chlorantraniliprole**  **Green Onion USA**  **2X0.1 la ai/A, 1 d PHI Total number of data (n)**  5 **Percentage of censored data** 0% **Number of non -**  **censored data** 5 **Lowest residue** 0.406 **Highest residue** 1.490 **Median residue** 0.717 **Mean** 0.811 **Standard deviation (SD)** 0.406 **Correction factor for censoring (CF)** 1.000 **Proposed MRL estimate**

**- Highest residue**  1.490

**- Mean + 4 SD**  2.435

**- CF x 3 Mean**  2.432 **Unrounded MRL** 2.435 **Rounded MRL 3**  High uncertainty of MRL estimate. [Small dataset] **Residues (mg/kg) n**  0.406 1 0.653 1 0.717 1 0.787 1 1.49 1 **Dried Green Onion** Dried green onion will be used as a representative of chives (D361791, D. Rate, 01/08/2010), which in turn is a representative commodity for herb subgroup 19A. Five trials were conducted with residues of 6.25, 1.00, 2.66, 10.8, and 1.48 ppm, which provided processing factors of 9.6x, 2.5x, 3.4x, 7.2x, and 2.1x. The median processing factor, 3.4x , applied to the green onion highest average field trial (HAFT) , 1.49 ppm, yields a tolerance estimate of 5 ppm. This contrasts to the existing tolerance of 90 ppm for dried herbs subgroup 19A. The existingChlorantraniliprole Summary of Analytical Chemistry and Residue Data Barcode D 407350

Page 44 of 44 tolerance will be retained, based on the previous translations and the lack of field trial data for the other representative commodity, basil (fresh and dried). Note that the registrant has not requested a change to this tolerance. **Dill Seed** Dill seed is one of the two representative commodities for the spices subgroup 19B. The other is black pepper. Two trials were conducted, and therefore the OECD MRL calculation spreadsheet cannot be used. In such situations, the tolerance estimate is t aken as 5 X Mean, or 5 X 19.4 = 92 ppm. The tolerance estimate for the spices subgroup 19B is 90 ppm. This replaces the existing estimate of 14 .0 ppm (D361791, D. Rate, 01/08/2010).