UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

March 4, 2015 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

Office of Pesticide Programs 

Registration Division (7505P) 

MEMORANDUM DER for acute toxicity studies for 100-RUAA 

Subject: Name ofthe Product SYN-A 19707 

EPA File Symbol: 100-RUAA 

DP Barcode 411844 

Decision No 4 70872 

Action Code: RO 10 

PC Code: 018986 

From: Princess Campbell, DVM, MS, DACVPM -v..\.__ ~ __ .\ ~ 

CITAB 

John Redden, M.S. _) (. rL. 

CITAB 

Through: 

Registration Division (7505P) 

To: Grant Rowland/Kathryn Montague RM 23 

Herbicide Branch 

Registration Division (7505P) 

Applicant: Syngenta Crop Protection, LLC. 

Greensboro, NC 27419 

FORMULATION FROM LABEL: 

Active Ingredient(s): 

S-Metolachlor 

Atrazine 

Mesotrione 

Bicyclopyrone 

Other lngredient(s): 

Total: 

%by wt. 

23.40 

10.93 

2.60 

0.65 

62.42 

100.0 
Bicyclopyrone (A19707) 

Reviewer: Princess Campbell, DVM 

BACKGROUND: 

Syngenta Crop Protection, LLC has submitted a set of six acute toxicity studies to support the 

registration of Bicyclopyrone, an herbicide. The toxicity studies were performed by RCC Ltd, 

Wolferstrasse 4, Switzerland, and Safepharm between 2007 and 2008 (MRlDs 4 7841966-71 ). 

Deficiencies: All studies are in compliance with EPA guidelines; any deficiency is not 

significant and does not affect the outcome of the study. 

FINDINGS: 

All six studies have been classified as acceptable. 

The toxicology profile is as follows: 

Acute oral toxicity IV acceptable 

Acute dermal toxicity IV acceptable 

Acute inhalation IV acceptable 

Primary eye irritation IV acceptable 

Primary dermal irritation IV acceptable 

Dermal sensitization -ve acceptable 

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MRID 4 7841966 

MRID 47841967 

MRID 47841968 

MRJD 47841970 

MRID 4 7841969 

MRID 47841971 
Bicyclopyrone (A19707) 

Reviewer: Princess Campbell, DVM 

LABEL: 

PRODUCT ID #: 000100-01466 

PRODUCT NAME: SYN-A19707 

PRECAUTIONARY STATEMENTS 

SIGNAL WORD: CAUTION 

Hazards to Humans and Domestic Animals: 

Wear: Long-sleeved shirt and long pants, Socks, Shoes, and chemical-resistant gloves (such as Natural 

Rubber, Selection Category A). 

User Safety Recommendations: 

Users should remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on 

clean clothing. 

Users should remove PPE immediately after handling this product. Wash the outside of gloves before 

removing. As soon as possible, wash thoroughly and change into clean clothing. 

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Bicyclopyrone (Al9707) 

Reviewer: Princess Campbell, DVM 

**DER ~ or F"l 1 e S ;ym b o I 100 -RUA A 

l. DP BARCODE: 411844 

2. PC CODE: 0 18986 

3. CURRENT DATE: February 4, 2015 

4. TEST ARTICLE: NOA449280; Batch #: SEZ3AP006/MILLED; Solid beige powder; 

Study/Species/Lab MRID Results Tox Core 

Study #/Date Cat Grade 

Acute oral toxicity I rat 47841966 LDso females is > 5000 mgfkg mg/ kg rv A 

RCC Ltd /835493/07-05-2007 

OCSPP 870.11 00; OECD 425 

Acute dermal toxicity /rat 47841967 Dermal LDso Males/females > 5000 IV A 

I RCC Ltd /835504/07-17-2007 mgfkgbw 

OCSPP 870.1200; OECD 402 

Acute inhalation toxicity I rat 47841968 LCso Males and females > 5.2 10 mg/L IV A 

RCC Ltd /845145/05-08-2008 MMAD= 3.10 1-1m 

OCSPP 870.1300; OECD 403 GSD = 3.22 

All survived exposure (nose only). 

Primary Skin irritation I rabbit 47841969 Non irritating IV A 

RCC Ltd/835515/05- 11 -2007 

OCSPP 870.2400; OECD 404 

Primary eye irritation I rabbit 47841970 Non irritating IV A 

RCC Ltd 1835526107-03-2007 

OCSPP 870.2500; OECD 405 

Dermal sensitization I mouse LLNA- 4784197 1 Negative. -- A 

Safepharm Laboratories Ltd Positive control (15% HCA): 

/2364/0053/01-08-2008 

OCSPP 870.2600 

Core Grade Key: A =Acceptable, S = Supplementary, U = Unacceptable, D =Data Gap 

**Detailed DER completed for acute toxicity studies (6 pack) in Global Joint Review format. 

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