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# OAR Box 1846

Prepped by Ollie Stewart

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Number: 

# 6 ) ll-B-3

Docket Number: 

# A-90-0 7

Printed 11/18/2008 7:30:14

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A » " ' ' ' SUBJECT : Transmitta l o f Fue l Toxicit y Reference s

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Standard s Developmen t an dSuppor t Branc h TO : Nanc y

Ketcham-Colwill , Attorne y Adviso r Offic e o f Genera l Counse l (L E 132A ) 

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Pe r you r request , attache di s a lis t o f selecte d reference s o nth e toxicit y o f gasolin e anddiese l fue l and thei r combustio nproducts . Pleas e not e tha t thi s i s no t mean t t o b e a complet e lis t o f al l publishe dpaper s an dreports / althoug hi t i s wort hnotin g tha t Referenc e 3 3 i s a bibliography tha t contain s 25 7 abstract s relate dt o the carcinogeni c ris ko f petroleu m - fuele dengin e exhaus t andevaporativ e emissions . Whil e thes e reference s appea r t o b e numerous , they d o no t reall y addres s th e ke y

Issue s tha t wil l fac e u s l nth e rulemaking . . specifically / non e o f th e studie s i s devote dt o a principl e topi c o f th e rulemaking : wha t testin g procedure s and protocol s ar e bes t suite dt o determinin g the healt handwelfar e effect s o f fuel s andfue l additives . Man y o f th e studie s addres s the healt heffect s o f exposur e t o th e primar y

component s o f exhaus t emissions . (The Agency' s extensiv e regulatio no f tailpip e emission s i nlarg e par t explain s th e availabilit y o f thes e studies. ) However , thes e studie s d o no t conside r the differences I nfue l formulation s o r fue l additives . Othe r studie s addres s th e healt heffect s o f exposur e t o fuel s themselves * bu t thei r scop e i s limite dt o on e typ e o f fuel , on e healt heffec t endpoint , and/o r on e typ e o f teat , indeed , th e studie s ar e prett y muc hlimite dt o gasolin e an ddiese l fuel ; non e consider s fue l additive s o r many o f th e alternativ e fuel s no

w bein g considered , I nshort , thes e reference s ar e valuabl e backgroundfo r developmen t o f a testin g rule , bu t the y d o no t contai na templat e fo r th e rul e itself . A substantia l amoun t o f wor k remain s t o be don e t o specif y procedure s an

d protocol s generall y

applicabl e t o the thousand s o f currentl y registere d fuel s an

dfue l additives , an dth e potentiall y

grea t numbe r t o b e registere di nth e futur e a s alternativ e fuel s ar e developed , » Pleas e le t u s kno

w i f yo unee dan

y additiona l information . Attachmen t

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Selecte dReference s onthe Toxicit y o f Gasolin e an

d Diese l Fue l andThei r Combustio nProduct ? * ~

1 . Rober t A , Scala , Exxo nBiomedica l Science s Incorporated , "Moto r Gasolin e Toxicity, " Fundamenta l an d Applie d Toxicology , 10 , 553-56 2 (1988) . 2 . Davi dJ . Lour y

an dByro nE . Butterworth , Chemica l Industr y Institut e o f Toxicology , "Kidney-Specifi c DN A Repai r Assay : A

nEvaluatio no f Unleade dGasoline, " CU T Activities , Vol , 6 , No , 4 , Apri l 1986 . 3 . Healt hEffect s Institute , "Gasolin e Vapo r Exposur e and Huma nCancer : Evaluatio no f Existin g Scientifi c informatio nan

dRecommendation s fo r Futur e Research, " Septembe r 1985 . 4 . Healt hEffect s institute , "A nUpdat e o

nGasolin e Vapo r Exposur e andHuma nCancer : AnEvaluatio no f Scientifi c Informatio nPublishe dBetwee n198 5 and 1987, " Januar y 6 , 1988 . 5 . U.S . EPA , Offic e o f Researc han dDevelopment , "Evaluatio n o f th e carcinogenicit y o f unleade dGasoline, " EPA/60Q/6-87/001 , Apri l 1987 , 6 . K.A . Richardson , e t al. , Chemica l Industr y institut e o f Toxicology , "Assessmen t o f the Genotoxi c Potentia l o f Unleade dGasolin e an d2,2,4-Trimethylpentan e i nHuma n Lymphoblast s i nVitro, " Toxicolog y an d Aoplie d Pharmacology , 82 , 316-32 2 (1986) . 7 . H.N . MacFarland , e t al, , " A Chroni c inhalatio nstud y wit h Unleade dGasolin e Vapor, " Journa l o f the America nColleg e o f Toxicology , Volum e 3 , Numbe r 4 , 1984 , 8 . "Feasibilit y

o f Assessmen t o f Healt hRisk s Fro m Vapor-Phas e Organi c Chemical s i nGasolin e an d Diese l Exhaust, " prepare db y th e Committe e onVapor-Phas e Organics , Nationa l Researc hCouncil , Nationa l Academ y Press , Washington , D.C , 1983 . 9 . "Materia l Safet y Dat a Sheet : Gasoline/Automotive, " Occupationa l Healt hServices , Inc. , Septembe r 1985 . 10 . J.F . Hansbrough , e t al, , "Hydrocarbo nContac t Injuries, " Th e Journa l o f Trauma , Vol . 25 , No . 3 , Marc h1985 . 11 . W . Machl« , "Oa*olin « Intoxication, " J . Amer . M*d . Assoc ,