# Patent

## Title
Method and device for wavelength shifted imaging

## Abstract

A micro-camera catheter device is disclosed having at least one light source disposed on a distal end of a catheter. The light source is capable of propagating a predetermined wavelength of light with a wavelength greater than approximately 700 nanometers onto a target. The device further includes a lens system disposed on the distal end of the catheter, said lens system configured to receive light reflected from the target. The device further includes a non-linear optical media disposed about the lens system configured to reduce the wavelength of light reflected from the target. The device also includes a silicon-based solid state imaging device disposed behind the non-linear optical media configured to receive light from the non-linear optical media.

## Background
CLAIM OF PRIORITY
This application claims priority to U.S. patent application Ser. No. 12/611,776 which was filed on Nov. 3, 2009 and issued as U.S. Pat. No. 9,060,704, and U.S. Patent Application No. 61/111,162 which was filed on Nov. 4, 2008, and which are incorporated herein by reference in their entirety.


FIELD OF THE INVENTION
The present invention relates to the field of miniaturized imaging devices. More specifically, the present invention relates to a device having a light source capable of propagating a predetermined wavelength of light onto a target, a lens system configured to receive light reflected from the target, and a non-linear optical media disposed about the lens system.
RELATED CASES
The present invention is related to U.S. patent application Ser. Nos. 10/391,489 and 11/292,902; and U.S. Pat. Nos. 7,166,537; 7,787,939; 7,835,074; 7,591,780; and 7,629,659, all of which are incorporated herein by reference in their entireties.
BACKGROUND
Minimally invasive diagnostic medical procedures are used to assess the interior surfaces of an organ by inserting a tube into the body. The instruments utilized may have a rigid or flexible tube and provide an image for visual inspection and photography, but also enable taking biopsies and retrieval of foreign objects. Analysis of image data collected during the inspection and imaging of the interior of the body cavity is a critical component of proper diagnosis of disease and other related conditions.
Examples of imaging devices presently used to view portions of the body convert an optical image to an electric signal. Well known types of silicon-based imaging devices capable of converting an optical image into an electrical signal include, for example, a set of charge-coupled devices (CCD) or complementary metal-oxide-semiconductor (CMOS) sensors. Two important characteristics of silicon-based imaging devices, such as the CMOS devices, are high noise immunity and low static power consumption. Significant power is only drawn when the transistors in the device are switching between on and off states. Consequently, the devices do not produce as much waste heat as other forms of logic, for example transistor-transistor logic (TTL). Importantly, silicon-based solid state imaging devices, such as the CMOS device, can only effectively duplicate optical images resulting from incident or direct wavelengths of light ranging from approximately 400 nanometers to approximately 1000 nanometers.
Non silicon-based solid state imaging devices (e.g., solid state imaging devices based on Indium Gallium Arsenide (InGaAs), Indium antimonide (InSb), Mercury Cadmium Telluride (HgCdTe)) are capable of detecting wavelengths of light greater than 1000 nanometers. However, these types of imaging devices require external readout devices as additional circuit components that cannot be fabricated on the same substrate as the detectors. Some also require a cooling component for proper operation. For example, InSb devices can only effectively operate under cryogenic conditions (about 80 degrees K). Additionally, the pixel size of the Indium Gallium Arsenide (InGaAs) device is an order of magnitude greater than CMOS devices. Accordingly, certain optical components used in the imaging system must be larger to compensate, thereby increasing the cost, size, and weight of the overall optical system.
SUMMARY OF THE INVENTION
It has been recognized that it would be advantageous to develop an improved micro-camera catheter device capable of capturing images using non-visible wavelengths of light while still maintaining the benefits of using silicon-based image sensors.
According to one embodiment of the present invention, a micro-camera catheter device is disclosed comprising at least one light source disposed on a distal end of a catheter. The light source is capable of propagating a predetermined wavelength of light with a wavelength between approximately 1000 nanometers and approximately 2000 nanometers onto a target. The device further comprises a lens system disposed on the distal end of the catheter. The lens system is configured to receive light reflected from the target. The device further comprises a non-linear optical media disposed behind the lens system wherein the non-linear optical media is configured to modify the light reflected from the target. The device also comprises a silicon-based solid state imaging device (SSID) disposed behind the non-linear optical media. The silicon-based SSID is configured to receive light from the non-linear optical media. In one aspect of the invention, the silicon-based SSID is essentially free of Gallium Arsenide.
In one embodiment of the invention, the lens system comprises a GRIN lens and the non-linear optical media comprises a non-linear optical crystal. In one aspect, the non-linear optical crystal consists of lithium niobate, potassium titanyl phosphate, or lithium triborate. In one aspect, the non-linear optical media comprises a film formed on the silicon-based solid state imaging device. In yet another aspect, the non-linear optical media comprises a film disposed on a proximal end of the lens system. In yet another aspect, the non-linear optical media comprises a film disposed on the SSID sensor.
In one embodiment of the present invention, the micro-camera catheter device further comprises a plurality of light sources configured to simultaneously propagate a predetermined wavelength of light. In this aspect, the respective wavelengths of light from the different light sources are different. In an additional embodiment, the device further comprising a filter media configured to selectively pass predetermined wavelengths of light and reflect predetermined wavelengths of light.
In yet another embodiment of the present invention, a micro-camera catheter device is disclosed comprising a plurality of light sources disposed on a distal end of a catheter. The plurality of light sources are capable of simultaneously propagating a predetermined wavelength of light with a wavelength between approximately 1000 nanometers and approximately 2000 nanometers onto a target. The device further comprises a GRIN lens disposed on the distal end of the catheter, said lens system configured to receive light reflected from the target. The device further comprises a non-linear optical crystal optically coupled to the lens system and a filter media optically coupled to the non-linear optical crystal. The filter media is configured to selectively pass predetermined wavelengths of light and reflect predetermined wavelengths of light. The device further comprises a silicon-based SSID optically coupled to the filter media.
In one aspect, each of the plurality of light sources are configured to propagate different wavelengths of light. In yet another aspect of the invention, the device comprises a plurality of GRIN lenses optically coupled to a plurality of silicon-based SSIDs.
According to an additional embodiment of the present invention, a method of imaging tissues using non-linear optical media is disclosed. The method comprises the step of propagating a predetermined wavelength of light onto a target tissue, said predetermined wavelength of light being greater than 1000 nanometers. The method further comprises receiving the predetermined wavelength of light reflected from the target tissue into and through a lens system and receiving the predetermined wavelength of light from the lens system into and through a non-linear optical media. The method further comprises modifying the predetermined wavelength of light and receiving at least a portion of the modified wavelength of light onto a silicon-based SSID.
In one aspect of the invention, the method further comprises simultaneously propagating a wavelength of light from a plurality of light sources, wherein the wavelength of light from each of the plurality of light sources is different. In yet another aspect, the method further comprises the step of selectively passing certain portions of the modified wavelength of light through a filter media and selectively reflecting certain portions of the modified wavelength of light off of a filter media.
In an additional aspect of the invention, the method further comprises the step of propagating a wavelength of light through a target media and onto the target tissue. In one aspect, the target media is blood. In yet another aspect of the invention, the method further comprises the step of propagating a wavelength of light through a first target tissue and onto a second target tissue.
In an additional embodiment, the method further comprises the step of simultaneously propagating an additional wavelength of light onto the target tissue, wherein said wavelength of light is less than approximately 1000 nanometers.



BRIEF DESCRIPTION OF THE DRAWINGS
Additional features and advantages of the invention will be apparent from the detailed description which follows, taken in conjunction with the accompanying drawings, which together illustrate, by way of example, features of the invention; and, wherein:
FIG. 1 is an exemplary view of a medical imaging system in accordance with an embodiment of the present invention;
FIG. 2 is a side view of a micro-catheter in accordance with one embodiment of the present invention;
FIG. 3 is a perspective view of an imaging structure according to one embodiment of the present invention; and
FIG. 4 is a perspective view of an imaging structure according to one embodiment of the present invention.



DETAILED DESCRIPTION OF EXAMPLE EMBODIMENT(S)
Reference will now be made to, among other things, the exemplary embodiments illustrated in the drawings, and specific language will be used herein to describe the same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended. Alterations and further modifications of the inventive features illustrated herein, and additional applications of the principles of the inventions as illustrated herein, which would occur to one skilled in the relevant art and having possession of this disclosure, are to be considered within the scope of the invention.
It must be noted that, as used in this specification and the appended claims, singular forms of “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise.
A “SSID,” “solid state imaging device,” “SSID chip,” or “solid state imaging chip” in the exemplary embodiments generally comprise an imaging array or pixel array for gathering image data. In one embodiment, the SSID can comprise a silicon or silicon-like substrate or amorphous silicon thin film transistors (TFT) having features typically manufactured therein. Features can include the imaging array, conductive pads, metal traces, circuitry, etc. Other integrated circuit components can also be present for desired applications. However, it is not required that all of these components be present, as long as there is a means of gathering visual or photon data, and a means of sending that data to provide a visual image or image reconstruction.
The terms “silicon-based solid state imaging device” or “silicon-based SSID” includes an SSID as described above which is substantially made from silicon or a silicon derivative. The silicon-based SSIDs do not produce as much waste heat as other SSIDs (such as InSb) and are configured to effectively duplicate optical images resulting from incident or direct wavelengths of light ranging from approximately 400 nanometers to approximately 1000 nanometers. In one aspect of the present invention, the silicon-based SSID is substantially free from any InGaAs materials.
The term “umbilical” can include the collection of utilities that operate the SSID or the micro-camera as a whole. Typically, an umbilical includes a conductive line, such as electrical wire(s) or other conductors, for providing power, ground, clock signal, and output signal with respect to the SSID, though not all of these are strictly required. For example, ground can be provided by another means than through an electrical wire, e.g., to a camera housing such as micromachined tubing, etc. The umbilical can also include other utilities such as a light source, temperature sensors, force sensors, fluid irrigation or aspiration members, pressure sensors, fiber optics, microforceps, material retrieval tools, drug delivery devices, radiation emitting devices, laser diodes, electric cauterizers, and electric stimulators, for example. Other utilities will also be apparent to those skilled in the art and are thus comprehended by this disclosure.
A “GRIN lens” or “graduated refractive index lens” refers to a specialized lens that has a refractive index that is varied radially from a center optical axis to the outer diameter of the lens. In one embodiment, such a lens can be configured in a cylindrical shape, with the optical axis extending from a first flat end to a second flat end. Thus, because of the differing refractive index in a radial direction from the optical axis, a lens of this shape can simulate the effects of a more traditionally shaped lens.
With these definitions in mind, reference will now be made to, among other things, the accompanying drawings, which illustrate, by way of example, embodiments of the invention.
Turning to the drawings, in which like reference numerals represent like or corresponding elements in the drawings, in one embodiment of the present invention, FIG. 1 illustrates a medical imaging system 10 comprising a micro-catheter 12 having an imaging device disposed at a distal tip 15 of the micro-catheter 12. A processor 22, such as an appropriately programmed computer, is provided to control the imaging system 10 and create an image of anatomy adjacent the distal tip portion 15, within a patient (not shown), displayable on a monitor 24, and storable in a data storage device 26. An interface 28 is provided which supplies power to the imaging device and feeds a digital image signal to the processor 22 based on a signal received from the imaging device via an electrical umbilical, including conductive wires through the micro-catheter 12. A light source (discussed in more detail further below) may also be provided at the distal end of the micro-catheter 12. In one aspect, the system 10 further includes a fitting 16 enabling an imaging fluid, such as a clear saline solution, to be dispensed to the distal tip portion of the micro-catheter 12 from a reservoir 18 through an elongated tubular member removably attached to the micro-catheter 12 or through a lumen of the micro-catheter 12 to displace body fluids as needed to provide a clearer image. Fluids may be pumped to the distal end of the micro-catheter for other reasons described herein. A pump 20 is provided, and is manually actuated by a medical practitioner performing a medical imaging procedure, or can be automated and electronically controlled so as to dispense fluid on demand according to control signals from the practitioner, sensors, or according to software commands.
With reference now to FIGS. 2 and 3, according to one embodiment of the present invention, an imaging device 30 is disposed on a distal end of a micro-catheter 12. Micro-machined cuts 13 are disposed non parallel to a longitudinal direction of the micro-catheter 12 to enable a user, such as a medical practitioner, to guide and steer the distal end of the micro-catheter 12 within a cavity of a patient. In one aspect of the present invention, the micro-catheter may incorporate structure and principles of operation from a catheter disclosed in U.S. Pat. No. 6,014,919 to Jacobsen et al., which is incorporated herein by reference.
In one aspect of the invention, imaging device 30 comprises at least two conductive wires 35a, 35b for conducting electronic image data to the data processor 22 and for securing an imaging structure between the at least two conductive wires 35a, 35b. As illustrated in FIG. 3 however, a plurality of conductive wires 35a, 35b, 35c, and 35d may be utilized. The at least two conductive wires 35a, 35b are oriented along a longitudinal axis of the imaging structure and are disposed within alignment apertures 40 of a planar support member 45. The planar support member 45 comprises at least two alignment apertures 40 disposed on opposing sides of the planar support member 45. The alignment apertures 40 are configured to receive and align the at least two conductive wires 35a, 35b along the longitudinal axis of the imaging structure. The imaging structure is at least partially secured between the at least two conductive wires 35a, 35b and is disposed adjacent a top surface of the planar support member 45. In one aspect of the invention, the imaging structure comprises a GRIN lens 50 optically coupled to a SSID 55 and disposed adjacent the SSID 55. The imaging structure further comprises an imaging array 60 disposed on a top surface of the SSID 55. In one embodiment, the GRIN lens 50 is positioned directly on top of the imaging array 60 of the SSID 55.
The at least two conductive wires 35a, 35b are operatively coupled to the imaging structure and are configured to align the imaging structure there between. In one aspect, the conductive wires 35a, 35b are bonded to the imaging structure at contact points 56 disposed on the periphery of a top surface of the SSID 55. In yet another embodiment, the conductive wires 35a, 35b are bonded to a side surface of the SSID 55.
In one embodiment, the alignment apertures 40 are oriented perpendicular to the top surface of the planar support member 45. However, the alignment apertures 40 may also be disposed in any orientation which is not non-parallel to the planar support member 45 as required to optimally align the imaging structure as desired. In one embodiment, the imaging structure is mounted and aligned such that the image plane of the imaging structure is non-parallel to a longitudinal axis of the micro-catheter 12. In one aspect of the invention, a light source (e.g., a fiber optic member, LED, etc.) 62 is disposed within an aperture of the planar support member 45 to provide light for imaging. In yet another aspect of the present invention, the imaging structure may incorporate structure and principles of operation from an imaging device disclosed in U.S. Pat. No. 7,166,537 to Jacobsen et al., which is incorporated herein by reference.
Referring now to FIGS. 3 and 4, the imaging device 30 further comprises a lens support member/light shield 65. In one aspect, the lens light shield 65 is bonded to a top surface of the SSID 55. In another aspect, the lens light shield 65 is bonded to a side surface of the SSID 55. In yet another aspect, the lens light shield 65 is bonded to a top surface of the planar support member 45. In any event, the lens support member 65 is oriented adjacent a side surface of the GRIN lens 50 to minimize stray light from entering the GRIN lens 50 during operation and to aid in proper alignment of the GRIN lens 50 on the imaging array 60 during operation and/or construction of the device 30. In one aspect of the invention, a first sleeve member 70 is disposed about the imaging structure. An adhesive is disposed within the first sleeve member 70 securing the components of the imaging structure in place as well as securing the first sleeve member 70 to the imaging structure. In an additional embodiment, a second sleeve member 75 is disposed about the first sleeve member 70 and secured with an adhesive. In one aspect of the invention, the second sleeve member 75 comprises an opaque material to eliminate secondary light from impacting image quality.
In accordance with one embodiment of the present invention, the imaging device 30 incorporates and utilizes principles of nonlinear polarization as noted in more detail below.
In general, nonlinear polarization for a material can be expressed as P=χ1E1+χ2E2+χ3E3 . . . where P is the induced polarization, χn is the nth order nonlinear susceptibility, and E is the electric field vector. The first term describes the normal absorption and reflection of light; the second term describes the second harmonic generation (SHG) and sum and difference frequency generation; and the third term describes light scattering, stimulated Raman processes, third harmonic generation (THG), and both two- and three-photon absorption. SHG does not arise from an absorptive process. Instead, an intense laser field induces a nonlinear polarization in a molecule or assembly of molecules, resulting in the production of a coherent wave at exactly twice the incident frequency (half the wavelength). The magnitude of the SHG wave can be resonance enhanced when the energy of the second harmonic wave overlaps with an electronic absorption band. Principles of SHG, sum frequency generation (SFG), and difference frequency generation (DFG) may all be employed herein to optimize image quality resulting from use of infrared wavelengths of light reflected from a target and directed towards the silicon-based SSID 55.
An optical frequency multiplier is a nonlinear optical device, which creates the above referenced frequency output. Examples of non-linear optical media utilized to achieve frequency multiplication includes, but is not limited to, non-linear optical crystals or non-linear polymers. Examples of non-linear optical crystals contemplated for use with exemplary embodiments of the present invention include, but are not limited to, potassium titanyl phosphate (KTiOPO4), Beta-Barium Borate (βBaB2O4), Potassium Dihydrogen Phosphate (KDP), Lithium triborate (LiB3O5), and Potassium Dideuterium Phosphate (KD*P). Other possibilities include but are not limited to Lithium Niobate (LiNbO3), Magnesium Oxide Doped Lithium Niobate Crystals (MgO:LiNbO3), Potassium Titanyl Phosphate (KTP), and KN (KNbO3) which is a peoskite-type crystal.
In one aspect of the invention, the non-linear optical media comprises a film of silicon nanoparticle microcrystals such as those described in U.S. Pat. No. 6,585,947 to Nayfeh et al. which is incorporated herein by reference in its entirety. In one aspect of the invention, the film is deposited on a top surface of the silicon-based SSID 55. In yet another aspect, the film is deposited on a proximal (i.e., rear) end of the lens system 50. Advantageously, when the film (or other non-linear optical media discussed herein) is disposed on a proximal end of the lens system 50, material need not be deposited directly on the SSID 55. In this manner, there are no concerns regarding material interference with operation of the SSID 55 and its electrical components.
According to one embodiment of the present invention, an imaging device 30 is disclosed comprising at least one light source 62 disposed on a distal end 15 of a catheter 12 capable of propagating a predetermined wavelength of light onto a target. The wavelength of light propagated from the light source 62 ranges between approximately 1000 nanometers and approximately 2000 nanometers. The micro-camera catheter device 30 further comprises a lens system 50 disposed on the distal end 15 of the catheter 12 as discussed above. The lens system 50 is configured to receive light reflected from the target. While specific reference to GRIN lenses are made herein, it is understood that any lens system may be used herein which has an optical output similar to that of a GRIN lens. In one aspect of the invention, a collimator (not shown) is disposed on a distal end of the lens system 50 to collect light reflected from the target and directed to the imaging system 10. The imaging device 30 further comprises a non-linear optical media 80 (such as the non-linear crystals discussed above) disposed behind the lens system 50 and configured to modify the light reflected from the target and a silicon-based SSID 55 disposed behind the non-linear optical media 80. The silicon-based SSID 55 is configured to receive the modified light from the non-linear optical media 80. In one aspect, the non-linear optical media 80 may be disposed on the lens system 50 by an adhesive, such as an isobutyl/butyl acrylic copolymer, or other suitable means.
Advantageously, the non-linear optical media 80 acts as an optical frequency multiplier effectively shifting the wavelength of light propagated onto the target to a wavelength of light which the silicon-based SSID 55 is capable of detecting and converting into an electrical signal for imaging purposes. As noted above, current silicon-based SSID technology cannot effectively detect wavelengths of light greater than 1000 nanometers. Devices which are capable of detecting and imaging wavelengths of light greater than 1000 nanometers suffer from one or more disadvantages. However, one embodiment of the present invention allows for tissue and/or other target media, which may be more effectively imaged using wavelengths of light ranging from approximately 1000 nanometers to approximately 2000 nanometers, to be imaged using well-developed silicon-based imaging technology. In sum, the end result of one embodiment of the present invention is a single wavelength of light which is capable of being detected by the silicon-based SSID 55 without the need for cooling devices or additional optical components to compensate for large pixel sizes. It is believed that longer wavelengths of light can feasibly be used with the camera disclosed herein, however the frequencies would have to be tripled rather than doubled. In one aspect of the invention, two non-linear optical devices may be placed in series to achieve a desired frequency multiplication effect.
In one aspect of the present invention, the light source 62 disposed on the distal end 15 of the catheter 12 comprises a laser configured to emit a high-power short wave infrared laser beam, including, but without limitation, an InGaAsP MQW, DFB (Multiple Quantum Well Distributed Feed Back) laser diode. However, any light source capable of propagating wavelengths of light greater than 1000 nanometers is contemplated for use herein.
In another embodiment of the present invention, the light source 62 disposed on the distal end 15 of the catheter 12 comprises an optical fiber and a light source coupled to the afore-mentioned fiber at a location remote to the distal end 15 of the catheter 12.
In another embodiment of the present invention, the imaging device 30 further comprises a plurality of light sources (not shown) configured to propagate a predetermined wavelength of light onto a target surface. In this aspect, the respective wavelengths of light from the different light sources are different. The different wavelengths of light can be combined in the non-linear optical media 80 in a SFG and/or DFG process to produce a single wavelength of light which is capable of being detected by the silicon-based SSID 55 without the need for cooling devices or additional optical components to compensate for large pixel sizes.
In yet another embodiment, the imaging device 30 further comprises a filter media 81 configured to selectively pass predetermined wavelengths of light and reflect predetermined wavelengths of light. The filter media 81 is disposed on a proximal (i.e., rear) portion of the non-linear optical media 80 or on the face of the silicon-based SSID 55. In some instances, a wavelength of light reflected from a target may by slightly modified as it is reflected from the target. Advantageously, the filter media 81 minimizes interference from undesired wavelengths of light which might otherwise be detected by the silicon-based SSID 55.
According to one embodiment of the present invention, the filter media 81 comprises a dichroic media, such as a dichroic filter or a dichroic mirror. A dichroic filter is a color filter used to selectively pass light of a small range of wavelengths while reflecting others. By comparison, dichroic mirrors and dichroic reflectors tend to be characterized by the wavelengths of light that they reflect, rather than the wavelengths of light they pass.
In another embodiment of the present invention, the filter media 81 comprises an anti-reflective coating. The anti-reflective coating is applied to either a proximal (i.e., rear) and/or distal (i.e., front) of lens system 50. In another aspect, the anti-reflective coating is disposed on the face of the silicon-based SSID 55. In one aspect, the anti-reflective coating comprises a transparent thin film structure with alternating layers of contrasting refractive index. Layer thicknesses are chosen to produce destructive interference in the wavelengths of light reflected from the interfaces, and constructive interference in the corresponding transmitted wavelengths of light. This makes the structure's performance change with wavelength and incident angle, so that color effects often appear at oblique angles. In one aspect, a second quarter-wave thick higher-index layer is added between a low-index layer and a substrate. The reflection from all three interfaces produces destructive interference and antireflection. Additionally, varying thicknesses of the coatings may be used as desired.
In an additional aspect of the invention, an absorbing anti-reflection coating may be used. These coatings are useful in situations where high transmission through a surface is unimportant or undesirable, but low reflectivity is required. This type of coating can produce very low reflectance with few layers, and can often be produced more cheaply, or at greater scale, than standard non-absorbing anti-reflective coatings. Examples of materials used in absorbing anti-reflective coatings include titanium nitride and niobium nitride.
In yet another embodiment of the present invention, a phosphor coating may be applied directly to the SSID 55. In one aspect, the phosphor coating comprises Y2O2S:ErYb, YF3:ErYb, NaYF4:ErYb, or other related wavelength conversion matrix as suits a particular application.
While reference has been made specifically herein to a single GRIN lens 50 used in connection with a single silicon-based SSID 55, it is understood and contemplated herein that a plurality of GRIN lenses (not shown) could be used with a plurality of silicon-based SSIDs (not shown). In one aspect, each of the single GRIN lens/silicon-based SSID pairs is provided with a filter media 81 designed to pass and reflect different wavelengths of light and/or non-linear optical media 80. The filter media 81 associated with each of the GRIN lens/silicon-based SSID pairs could be designed to pass/reflect wavelengths of light which are different from a corresponding GRIN lens/silicon-based SSID pair. Advantageously, each GRIN lens/silicon-based SSID pair could receive light reflected from the same target but receive different wavelengths of light reflected from the target. In this manner, a composite image (or multiple images) could be created from the plurality of imaging devices receiving different wavelengths of light reflected from the same target. In one aspect, it is believed that a resulting composite image would have enhanced clarity. In another aspect, an optimal image may be selected from each of the GRIN lens/silicon-based SSID pairs and utilized for display of the target area. Similar modifications (i.e., multiple GRIN lens/silicon-based SSID pairs with different light polarization characteristics) could be made to the non-linear optical media 80 to suit a particular application. In one aspect of the invention, light source 62 is configured to selectively propagate different wavelengths of light at different intervals to accommodate the above contemplated invention.
Referring now generally to FIGS. 1 through 4, according to an additional embodiment of the present invention, a method of imaging tissues using a non-linear optical system is disclosed. The method comprises propagating a predetermined wavelength of light onto a target tissue wherein said predetermined wavelength of light being greater than 700 nanometers. The method further comprises receiving the predetermined wavelength of light reflected from the target tissue into and through a lens system 50. In one aspect of the invention, the lens system 50 is a GRIN lens. The method further comprises receiving the predetermined wavelength of light from the lens system 50 into and through a non-linear optical media 80. As noted above, the non-linear optical media may comprise a non-linear crystal such as potassium titanyl phosphate (KTiOPO4), Beta-Barium Borate (βBaB2O4), Potassium Dihydrogen Phosphate (KDP), Lithium triborate (LiB3O5), and Potassium Dideuterium Phosphate (KD*P). The method further comprises modifying the predetermined wavelength of light and receiving at least a portion of the modified wavelength of light onto a silicon-based SSID 55.
In yet another embodiment, the method further comprises simultaneously propagating a wavelength of light from a plurality of light sources (not shown), wherein the wavelength of light from each of the plurality of light sources is different. Alternatively, different wavelengths of light are propagated from a single light source at different time intervals.
In an additional aspect, the method further comprises the step of selectively passing certain portions of the modified wavelength of light through a filter media 81 and/or selectively reflecting certain portions of the modified wavelength of light off of a filter media 81. Advantageously, by propagating separate and distinct wavelengths of light onto an object, an optimal image may be obtained by selectively determining which wavelength of light results in an optimal image. Exemplary techniques for determining image optimization include passive auto-focus techniques such as phase detection and/or contrast measurement.
In one embodiment of the invention, the method further comprises the step of propagating a wavelength of light through a target media, such as blood, and onto the target tissue. Because blood becomes transparent to wavelengths of light near 1550 nanometers, the light propagated at this wavelength would effectively “see through” the blood and reflect off of a target behind the blood. In like manner, other tissues exist which certain wavelengths of light may pass through. As such, the method further comprises the step of propagating a wavelength of light through a first target tissue and onto a second target tissue.
In an additional aspect of the invention, the method further comprises the step of simultaneously propagating an additional wavelength of light onto the target tissue, wherein said wavelength of light is less than approximately 700 nanometers (i.e., in the visible light spectrum). In this manner, an additional GRIN lens/silicon-based SSID may verify proper positioning and/or placement of the catheter 12 within portions of a subject.
While the forgoing examples are illustrative of the principles of the present invention in one or more particular applications, it will be apparent to those of ordinary skill in the art that numerous modifications in form, usage, material selection and details of implementation can be made without the exercise of inventive faculty, and without departing from the principles and concepts of the invention. Accordingly, it is not intended that the invention be limited, except as by the claims set forth below.

## Claims

1. A method of imaging tissues using non-linear optical media, comprising:
placing a medical device within a body of a patient;
propagating a predetermined wavelength of light onto a target tissue located within the body of the patient from a distal end of the medical device, said predetermined wavelength of light being greater than 700 nanometers;
receiving a portion of the predetermined wavelength of light propagated from the device and reflected from the target tissue into and through a lens system;
passing the predetermined wavelength of light from the lens system into and through a non-linear optical media, the non-linear optical media being disposed in series with and behind the lens system;
reducing the predetermined wavelength of light passed through the non-linear optical media at least by half; and
receiving at least a portion of the at least halved wavelength of light onto a silicon-based solid state imaging device.

2. The method of claim 1, further comprising the step of propagating a second predetermined wavelength of light onto the target tissue located within the body of the patient from the distal end the elongate device disposed within the body of the patient, said second predetermined wavelength of light being less than 700 nanometers.

3. The method of claim 2, further comprising the step of receiving at least a portion of the second predetermined wavelength of light reflected from the target tissue into and through a second lens system and onto a second silicon-based solid state imaging device.

4. The method of claim 3, further comprising the step of generating an image of the target tissue using the portion of the at least halved wavelength of light received by the silicon-based solid state imaging device and the second predetermined wavelength of light received by the second silicon-based solid state imaging device.

5. The method of claim 1, further comprising the step of generating an image of the target tissue using the portion of the at least halved wavelength of light received by the silicon-based solid state imaging device.

6. The method of claim 1, further comprising simultaneously propagating a wavelength of light from a plurality of light sources, wherein the wavelength of light from each of the plurality of light sources is different.

7. The method of claim 1, further comprising the step of selectively passing certain portions of the at least halved wavelength of light through a filter media.

8. The method of claim 1, further comprising the step of selectively reflecting certain portions of the at least halved wavelength of light off of a filter media.

9. The method of claim 1, further comprising the step of propagating the wavelength of light through a target media and onto the target tissue, the target tissue being disposed behind the target media.

10. The method of claim 9, wherein the target media is blood.

11. The method of claim 1, further comprising the step of propagating a wavelength of light through a first target tissue and onto a second target tissue, the second target tissue being disposed behind and covered by the first target tissue.

12. The method of claim 1, further comprising the step of simultaneously propagating a second wavelength of light onto the target tissue, wherein said second wavelength of light is less than approximately 1000 nanometers.

13. The method of claim 12, further comprising the step of receiving the second wavelength of light through a second lens system and onto a second solid state imaging device.

14. A method of imaging tissue within a body that is covered by an opaque material, comprising:
placing a medical device within a cavity of a patient,
propagating a predetermined wavelength of light through a first substantially opaque material covering a target tissue located within the body of the patient from a distal end of the medical device, said predetermined wavelength of light being greater than 1500 nanometers;
receiving a portion of the predetermined wavelength of light propagated from the device reflected from the target tissue into and through a lens system;
passing the predetermined wavelength of light from the lens system into and through a non-linear optical media, the non-linear optical media being disposed in series with and behind the lens system;
reducing the predetermined wavelength of light passed through the non-linear optical media to below 1000 nanometers;
receiving at least a portion of the reduced wavelength of light onto a silicon-based solid state imaging device; and
generating an image of the target tissue covered by the substantially opaque material.

15. The method of claim 14, wherein the opaque material comprises blood.

16. The method of claim 15, wherein the opaque material comprises tissues within the body other than the target tissue.

17. A micro-camera catheter device, comprising:
at least one light source disposed on a distal end of a catheter, said light source capable of propagating a predetermined wavelength of light onto a target, the wavelength being between approximately 1000 nanometers and approximately 2000 nanometers;
a lens system disposed on the distal end of the catheter, said lens system configured to receive light propagated from the light source and reflected from the target;
a non-linear optical device disposed behind the lens system, the non-linear optical device configured to reduce the wavelength of the light reflected from the target at least by half; and
a silicon-based SSID disposed behind the non-linear optical device, said silicon-based SSID configured to receive the at least halved wavelength of light thereon.

18. The micro-camera catheter device of claim 17, further comprising a second non-linear optical device placed in series with the first non-linear optical device.

19. The micro-camera catheter device of claim 17, further comprising a processor and an image display configured to generate and display an image based on at least the light received by the silicon-based SSID.

20. The micro-camera catheter device of claim 17, wherein the device is configured to simultaneously propagate a plurality of different wavelengths of light from a light source disposed on the device.