### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 2 of 18 

## Executive Summary

At the request of Registration Division, an acute and chro nic dietary risk assessment for flumioxazin was conducted using the Dietary Exposure Evaluation Model (DEEM

- FCID, Version 2.03) which uses food consumption data from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by Individuals (CS FII) from 1994

- 1996 and 1998

. This analysis was performed to estimate the acute and chronic dietary (food and drinking water) risk resulting from current and new uses of flumioxazin on field pea, flax, lentil, sunflower, safflower, and w heat commodities

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

An unrefined, acute dietary exposure assessment using tolerance levels , processing factors, and assuming 100% crop treated (CT) for the proposed commodities was

conducted for th e general U.S. population and various population subgroups . The estimated drinking water concentration of flumioxazin was provided by the Environmental Fate and Effects Division (EFED) and incorporated directly into the acute

assessment. An estimated env ironmental concentrations (EECs) for flumioxazin and its major degradates (482

- HA and APF) under the use as an aquatic herbicide of 400 ppb

was estimated for acute exposure.

There were no appropriate toxicological effects attributable to a single exposure (dose) for the general population or any other population subgroups except females 13

- 49 years

old ; therefore

, these population subgroups were not included in this assessment. For food and drinking water, the acute dietary risk estimate is below HED’s le vel of concern (<100% of the acute population adjusted dose (aPAD)) at the 95 th 

## percentile of exposure. The acute dietary exposure estimate for females 13

- 49 years old is 0.0 203 49 mg/kg/day ( 68 % of the aPAD)

.

Chronic Dietary (Food and Drinking Water) Exp osure Results and Characterization

The chronic dietary exposure and risk estimates are conservative since they assume that 100% of crops are treated , processing factors, and that the residues are present at the

t olerance levels. The EECs for flumioxazin a nd its major degradates (482

- HA and APF) under the use as an aquatic herbicide is 142 ppb. C ombined chronic dietary exposure estimates for food and drinking water are well below HED’s level of concern. Using the

DEEM

- FCID software, dietary exposure is e stimated at 0.0 039 76 mg/kg/day for the general U.S. population, which is equivalent to 20 % of the chronic Population Adjusted Dose (cPAD), and 0.01 08 63 mg/kg/day, equivalent to 54 % of the cPAD for all infants ( < 1year old ) , the population subgroup with the highest estimated chronic dietary exposure

to flumioxazin

.

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

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Page 3 of 18 

## Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

F lumioxazin is classified as a “ N ot likely to be carcinogenic to humans.” Therefore, a cancer dietary exposure analysis is not required

.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose. This is the populat ion adjusted dose (PAD), which HED has

concluded will result in no unreasonable adverse health effects. The PAD is the Reference Dose (RfD) divided by the FQPA Safety Factor. Dietary risk is expressed as a percentage of the PAD. For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References which

discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exp osure from Pesticides, A User’s Guide”, 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA

- PEST/2000/July/Day

- 12/6061.pdf ; or see SOP 99.6 (8/20/99).

The most recent dietary risk assessment for flumioxazin was conducted by W. Cutchin

, DP# 379036

, 6/16/1 0

.

II. Residue Information

Flumioxazin belongs to the N

- phenylphthalimide class of herbicides (Group 14) and is currently registered for pre

- and post

- emergence applications on a variety of fruit, vegetable, and field crops for the control of susceptible weeds. Tolerances are currently established for residues of the herbicide flumioxazin in/on various plant commodities, at levels ranging from 0.02 to 8. 0 ppm (as listed in e

- CFR 40 §180.568 [a] , u pdated April

, 20 12 ).

The residue of concern for both the tolerance expression and risk assessment in plants is

flumioxazin. No livestock tolerances have been established. A tolerance for combined

residues of flumioxazin and its metabolites APF (3

- oxo

- 4

- prop

- 2ynyl

- 6

- amino

- 7

- fluoro

3,4

- dihydro

- 1,4

- benzoxazin) and 482

- HA (N

- (7

- fluoro

- 3,4

- dihdyro

- 3

- oxo

- 4

- prop

- 2

- ynyl

2H

- 1,4

- benzoxazin

- 6

- yl)cyclohex

- 1

- ene

- 1

- carboxamide

- 2

- carboxylic acid) in freshwater

fish.

The proposed use and the submitted data support the following tolerances for residues of

flumioxazin in/on the following commodities:

Pea and bean, dried shelled, except soybean, subgroup 6C

....................... 0.07 ppm Rapeseed subgroup 20A

................................ ................................ ............ 0.40 ppm Sunflower subgroup 20B

................................ ................................ ........... 0.50 ppm

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

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Page 4 of 18 

## Wheat, grain

................................ ................................ ............................... 0.40 ppm

DEEM 7.81 processing factors were used for all processed commodities, with th e exception of tomato which used the empirical processing factor of one. A tomato processing factor of 1 is based on an exaggerated (~5x) crop field trial study in which no

residues were recovered; therefore, a processing study is not required (47005106.d er.com, D. Rate, 6/19/ 07). 100 %CT was assumed for all commodities in this

assessment.

III. Drinking Water Data

References: Drinking Water Assessment for a Section 3 New Use for Flumioxazin End

Use Products Chateau WDG and Valor WDG Applications to Wh eat, Sunflower, Safflower, Flax, Lentils, and Field Peas

, D392618, Larry Liu, 3/21/2012.

A Tier I screening level drinking water assessment was conducted to support the human

health risk asses sment for the proposed new use for f ield pea, flax, lentil, sun flower, safflower, and w heat . The previous drinking water assessment (D379036, W.Cutchin, 6/16/10) for use of flumioxazin on cotton, almonds, grapes, Christmas trees, deciduous trees and container and field grown ornamentals can be used for the currently proposed uses of Chateau WDG and Valor Herbicides. Since the maximum single application rate for the proposed uses (0.1 lb ai/A) is lower than the maximum single application rate (0.38 lb ai/A) used in the previous drinking water assessment. Also, the max imum yearly/seasonal application rate for the proposed uses (0.1 lb/A/year) is lower than the maximum yearly/seasonal application rate (0.76 lb/A/year) used in the previous drinking

water assessment. Water residues were incorporated in the DEEM

- FCID into the food categories “water, direct, all sources” and “water, indirect, all sources .”

T he EECs for flumioxazin and the metabolites 482

- HA and APF are the residues of concern in drinking water. In order to be conservative, EECs for flumioxazin and its maj or degradates (482

- HA and APF) as a result of the use as an aquatic herbicide of 0.400 ppm ( peak day

- 0) for acute exposure and of 0.142 ppm (30

- days) for chronic

exposure w ere used in the dietary analyses . Table 1 lists degradates identified and their

rela tive concentrations. The model and its description are available at the EPA internet

site: http://www.epa.gov/oppefed1/models/water/

.

Table 1. EECs (ppb) From the Subsurface Application of Flumi oxazin as an Aquatic Herbicide Compound Peak EEC (Day 0) EEC at Days 30 and

after 1



## Flumioxazin 400 10.4

482

- HA

- 21.6

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 5 of 18 

## APF

- 110.1

THPA

- 88.9

1 

### Total E E C = Sum of Flumioxazin + 482

- HA + APF



## IV

. DEEM

- FCIDTM Program and Consumption Information

Flumio xazin acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM

- FCIDTM, Version 2.03), which incorporates consumption data from USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII), 1994

- 1996 and 1998. The

1994

- 96, 98 data are based on the reported consumption of more than 20,000 individuals

over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked

to EPA

- defined f

ood commodities (e.g. apples, peeled fruit

- cooked; fresh or N/S; baked;

or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption d ata are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on analysis of the 1994

- 96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or

food

- form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption e stimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue

list to arrive at the to tal average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one

- day food consumption data are used on

a n individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple rand om pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis. However, for tiers 1 and 2, any significant differe nces in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 6 of 18 

## V. Toxicological Information

The findings of the flumioxazin risk assessment team, relative to dietary exposure, are

summarized in Table 2 (below) . In accordance with the EPA Draft Guidelines for Carcinogen Risk Assessment (July, 1999), flumioxazin was classified as “not likely to be carcinogenic to humans.”

Table 2

. Summary of Toxicological Doses and Endpoints for Use in Human Health Dietary

R isk Assessment for Flumioxazin.

Exposure/

Scenario Point of

Departure Uncertainty/

FQPA Safety

Factors RfD, PAD,

Level of

Concern Study and Toxicological

Effects

Acute Dietary (General Population, including Infants and Children) No endpoint attributab le to a single dose (exposure) was identified in the available

studies, including the developmental toxicity studies in rats and rabbits.

Acute Dietary

(Females 13

- 49 years of age) NOAEL = 3

mg/kg/day UF A 

### = 10x

UF H 

### = 10x

FQPA SF = 1X

Total UF = 100X Ac ute RfD =

NOAEL UF =

0.03 mg/kg/day

aPAD = 0.03 mg/kg/day Oral developmental and

supplemental prenatal studies

in the rat.

LOAEL = 10 mg/kg/day

based on cardiovascular effects (especially ventricular septal defects in fetuses).

Chronic Dietary (All Populations) NOAEL = 2

mg/kg/day UF A 

### = 10x

UF H 

### = 10x

FQPA SF = 1X

Total UF = 100X Chronic RfD

FQPA SF = 0.02 mg/kg/day

cPAD = 0.02 mg/kg/day 2

- year chronic/carcinogenicity

study in the rat.

LOAEL = 18 mg/kg/day

based on increased chronic nephropath y in males, and decreased hematological parameters in females (Hgb, MCV, MCH, and MCHC).

Cancer (oral, dermal, inhalation) Classification: “Not likely to be Carcinogenic to Humans” based on

the lack of carcinogenicity in a 2

- year rat study, an 18

- mon th mouse study, and a battery of mutagenic studies.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower e nvironmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A 

### = extrapolation from animal to human (intraspecies). UF H 

### = potential variation in sensitivity among members of the human population (interspecies). UF L 

### = use of a LOAEL to extrapolate a NOAEL. UF S = 

### use of a short

- term study for long

- term risk assessment. UF DB 

### = to account for the absence of key data (i.e., lack of a critical study). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = ch ronic). RfD =

reference dose

.

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 7 of 18 

## V I

. Results/Discussion

As stated above, for acute or chronic dietary assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The D EEM

- FCID analyses estimate the dietary exposure of the US population and various population subgroups. The results reported in

Table 3 (below) are for the general US population (total), all infants <1, children 1

- 2,

children 3

- 5, children 6

- 12, youths 13

- 19, females 13

- 49, adults 20

- 49, and adults 50+ for chronic exposure and females 13

- 49 for acute exposure.

Results of Acute Dietary Exposure Analysis

Flumioxazin acute dietary (food + water ) exposure estimates using the DEEM

- FCIDTM

software are below H ED ’s level of concern for females 13

- 49 . The acute dietary exposure for the females, 13

- 49 years old, utilized 6 8 % of the aPAD at the 95 th


## percentile

.

Results of Chronic Dietary Exposure Analysis

Flumioxazin chronic dietary (food + water) exposure estim ates using the DEEM

- FCIDTM

software are below HED ’s level of concern for the U.S. population and each of the population subgroups

. Chronic dietary exposure utilized 20 % of the cPAD for the U.S. population. T he chronic dietary exposure for the highest repo rted exposed population subg roup, all infants (<1 year old) , was 54 % of the cPAD

.

Table 3 . Summary of Dietary Exposure and Risk for Flumioxazin.

Population Subgroup 1 

## DEEM Acute Dietary Analysis,

95 th 

## Percentile DEEM Chronic Dietary Analysis

aPAD (m g/kg /day ) Exposure

(mg/kg/day) %

aPAD cPAD (mg/kg/day) Exposure

(mg/kg/day) %

cPAD

General U.S. Population

NA 2 

## 0.02 0.0039 76 20

All Infants (< 1 year old) 0.02 0.010 8 63 5 4

Children 1

- 2 years old 0.02 0.00 68 44 34

Children 3

- 5 years old 0.02 0.00 65 16 33

Children 6

- 12 years old 0.02 0.00 4 49 0 2 3

Youth 13

- 19 years old 0.02 0.00 3 101 16

Adults 20

- 49 years old 0.02 0.003 5 65 1 8

Adults 50+ years old 0.02 0.003 6 27 1 8

Females 13

- 49 years old 0.03 0.0 203 49 6 8 0.02 0.003 5 36 1 8

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 8 of 18 1 

### Values for the population with the highest risk for each type of risk assessment are bolded

. 2 

### NA = Not Applicable; no acute dietary endpoi nt was identified for these population subgroups



## VII. Characterization of Inputs/Outputs

The assumptions made in this assessment are conservative, and are very likely to result in exposure and risk values that considerably overestimate actual dietary e xposure to
flumioxazin. Although not needed at this time, t he analy se s could be further refined through the use of average residues based on field trial data, percent crop treated data and/or preparation/cooking factors. Since risk estimates are below HE D ’s level of concern, a more highly refined analysis is not needed at this time

.

VI I I

. Conclusions

This highly conservative, unrefined analysis demonstrates that the requested uses for flumioxazin will not result in acute and chronic dietary risk estima tes that exceed HED’s level of concern for any of the regulated populated subgroups, including those comprised

of infants and children.

I X

. List of Attachments

Attachment 1: Acute Food plus Water Residue Input File

Attachment 2: Acute Results File

At tachment 3: Chronic Food plus Water Residue Input File

Attachment 4 : Chronic Results File

Attachment 5 : Chemical Structure of Flumioxazin and metabolites (482

- HA and APF)

.

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 9 of 18 

## Attachment 1: Acute Food plus Water Residue Input File

Filen ame: C: \ Deemfcid \ Flumioxazin_acute.R98 Chemical: Flumioxazin RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .03 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day
Date created/last modified: 05

- 10

- 2012/14:34:11/8 P rogram ver. 2.03 Comment: Food + Drinking Water

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 01030150 1CD Arrowroot, flour 0.020000 1.000 1.000
01030151 1CD Arrowroot, flour

- babyfood 0.020000 1.000 1.00 0
01030170 1CD Artichoke, Jerusalem 0.020000 1.000 1.000

01030820 1CD Cassava 0.020000 1.000 1.000

01030821 1CD Cassava

- babyfood 0.020000 1.000 1.000
01031390 1CD Dasheen, corm 0.020000 1.000 1.000 01031660 1CD Ginger 0.020000 1.000 1.000 01031661 1CD Ginger

- babyfood 0.020000 1.000 1.000 01031670 1CD Ginger, dried 0.020000 1.000 1.000 01032960 1C Potato, chips 0.020000 1.000 1.000 01032970 1C Potato, dry (granules/ flakes) 0.020000 6.500 1.000 01032971 1C Potato, dry (granules/ flakes)

- b 0.020000 6.500 1.000

01032980 1C Potato, flour 0.020000 1.000 1.000
01032981 1C Potato, flour

- babyfood 0.020000 1.000 1.000 01032990 1C Potato, tuber, w/peel 0.020000 1.000 1.000 01032991 1C Potato, tuber, w/peel

- babyfood 0.020000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 01033001 1C Potato, tuber, w/o peel

- babyfood 0.020000 1.000 1.000 01033660 1CD Sweet potato 0.020000 1.000 1.000

0 1033661 1CD Sweet potato

- babyfood 0.020000 1.000 1.000
01033710 1CD Tanier, corm 0.020000 1.000 1.000

01033870 1CD Turmeric 0.020000 1.000 1.000
01034060 1CD Yam, true 0.020000 1.000 1.000

01034070 1CD Yam bean 0.020000 1.000 1.000

03001640 3 Garlic 0.020000 1.000 1.000
03001650 3 Garlic, dried 0.020000 9.0 00 1.000
03001651 3 Garlic, dried

- babyfood 0.020000 1.000 1.000 03002370 3 Onion, dry bulb 0.020000 1.000 1.000 03002371 3 Onion, dry bulb

- babyfood 0.020000 1.000 1.000

03002380 3 Onion , dry bulb, dried 0.020000 9.000 1.000 03002381 3 Onion, dry bulb, dried

- babyfood 0.020000 9.000 1.000

04020760 4B Cardoon 0.020000 1.000 1.000 04020850 4B Celery 0 .020000 1.000 1.000 04020851 4B Celery

- babyfood 0.020000 1.000 1.000 04020860 4B Celery, juice 0.020000 1.000 1.000

04020870 4B Celtuce 0.020000 1.000 1.000

040215 20 4B Fennel, Florence 0.020000 1.000 1.000

04023220 4B Rhubarb 0.020000 1.000 1.000

04023670 4B Swiss chard 0.020000 1.000 1.000 06003470 6 Soybean, seed 0.020000 1.000 1.000 06003480 6 Soybean, flour 0.020000 1.000 1.000 06003481 6 Soybean, flour

- babyfood 0.020000 1.000 1.000 06003490 6 Soybean, soy milk 0.020000 1.000 1 .000 06003491 6 Soybean, soy milk

- babyfood or in 0.020000 1.000 1.000 06003500 6 Soybean, oil 0.020000 1.000 1.000 06003501 6 Soybean, oil

- babyfood 0.020000 1.000 1.000
06030300 6C Bean, blac k, seed 0.070000 1.000 1.000 new us

Full comment: new use
06030320 6C Bean, broad, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030340 6C Bean, cowpea, seed 0.070 000 1.000 1.000 new us

Full comment: new use 06030350 6C Bean, great northern, seed 0.070000 1.000 1.000 new us

Full comment: new use

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

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Page 10 of 18 06030360 6C Bean, kidney, seed 0.070000 1.000 1.000 new us

Full comment: new use
06030380 6C Bean, lima, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030390 6C Bean, mung, seed 0.070000 1.000 1.000 new us

Full comment: new use

0 6030400 6C Bean, navy, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030410 6C Bean, pink, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030420 6C Bean, pinto, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030980 6C Chickpea, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030981 6C Chickpea, seed

- babyfood 0.070000 1 .000 1.000 new us

Full comment: new use 06030990 6C Chickpea, flour 0.070000 1.000 1.000 new us

Full comment: new use
06031820 6C Guar, seed 0.070000 1.000 1.000 new us

Full comment: new use
06031821 6C Guar, seed

- babyfood 0.070000 1.000 1.000 new us

Full comment: new use
06032030 6C Lentil, seed 0.070000 1.000 1.000 new us

Full comment: new use

06032560 6C Pea, dry 0.070000 1.000 1.000 new us

Full comment: new use 06032561 6C Pea, dry

- babyfood 0.070000 1.000 1.000 new us

Full comment: new use 06032580 6C Pea, pigeon, seed 0.070000 1.000 1.000 new us

Full comment: new use 08001480 8 Eggplant 0.020000 1.000 1.000

08002340 8 Okra 0.020000 1.000 1.000 08002700 8 Pepper, bell 0.020000 1.000 1.000 08002701 8 Pepper, bell

- babyfood 0.020000 1.000 1.000 08002710 8 Pepper, bell, dried 0.020000 1.000 1.000 08002711 8 Pepper, bell, dried

- babyfood 0.020000 1. 000 1.000 08002720 8 Pepper, nonbell 0.020000 1.000 1.000 08002721 8 Pepper, nonbell

- babyfood 0.020000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.020000 1.000 1.000

08003740 8 Toma tillo 0.020000 1.000 1.000

08003750 8 Tomato 0.020000 1.000 1.000

08003751 8 Tomato

- babyfood 0.020000 1.000 1.000 08003760 8 Tomato, paste 0.020000 1.000 1.000 08003761 8 Tomato, paste

- babyfood 0.020000 1.000 1.000 08003770 8 Tomato, puree 0.020000 1.000 1.000 08003771 8 Tomato, puree

- babyfood 0.020000 1.000 1.000

08003 780 8 Tomato, dried 0.020000 1.000 1.000
08003781 8 Tomato, dried

- babyfood 0.020000 1.000 1.000 08003790 8 Tomato, juice 0.020000 1.000 1.000 09010750 9A Cantaloupe 0.030000 1.000 1.000

09010800 9A Casaba 0.030000 1.000 1.000 09011870 9A Honeydew melon 0.030000 1.000 1.000

09013990 9A Watermelon 0.030000 1.000 1.000 09014000 9A Watermelon, juice 0.030000 1.000 1.000 09020210 9B Balsam pear 0.030000 1.000 1.000 09020880 9B Chayote, fruit 0.030000 1.000 1.000

09021020 9B Chinese w axgourd 0.030000 1.000 1.000

09021350 9B Cucumber 0.030000 1.000 1.000 09023080 9B Pumpkin 0.030000 1.000 1.000 09023090 9B Pumpkin, seed 0.030 000 1.000 1.000 09023560 9B Squash, summer 0.030000 1.000 1.000 09023561 9B Squash, summer

- babyfood 0.030000 1.000 1.000 09023570 9B Squash, winter 0.030000 1.000 1.000

09023571 9 B Squash, winter

- babyfood 0.030000 1.000 1.000 11000070 11 Apple, fruit with peel 0.020000 1.000 1.000 11000080 11 Apple, peeled fruit 0.020000 1.000 1.000

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

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Page 11 of 18 11000081 11 Apple, peeled fruit

- babyfoo d 0.020000 1.000 1.000 11000090 11 Apple, dried 0.020000 8.000 1.000 11000091 11 Apple, dried

- babyfood 0.020000 8.000 1.000 11000100 11 Apple, juice 0.020000 1.300 1.000 11000101 11 Apple, juice

- babyfood 0.020000 1.300 1.000 11000110 11 Apple, sauce 0.020000 1.000 1.000 11000111 11 Apple, sauce

- babyfood 0.020000 1.000 1.000 11001290 11 Crabapple 0.020000 1.000 1.000 11002100 11 Loquat 0.020000 1.000 1.000

11002660 11 Pear 0.020000 1.000 1.000

11002661 11 Pear

- babyfood 0.020000 1.000 1.000
11002670 11 Pear, dried 0.020000 6.250 1.000 11002680 11 Pear, juice 0.020000 1.000 1.000 11002681 11 Pear, juice

- babyfood 0.020000 1.000 1.000
11003100 11 Q uince 0.020000 1.000 1.000 12000120 12 Apricot 0.020000 1.000 1.000 12000121 12 Apricot

- babyfood 0.020000 1.000 1.000 12000130 12 Apricot, dried 0.020000 6.000 1.000 12000140 12 Apricot, juice 0.020000 1.000 1.000 12000141 12 Apricot, juice

- babyfood 0.020000 1.000 1.000 12000900 12 Cherry 0.020000 1.000 1.000

12 000901 12 Cherry

- babyfood 0.020000 1.000 1.000 12000910 12 Cherry, juice 0.020000 1.500 1.000 12000911 12 Cherry, juice

- babyfood 0.020000 1.500 1.000

12002300 12 Nectarine 0.020000 1.000 1.000

12002600 12 Peach 0.020000 1.000 1.000

12002601 12 Peach

- babyfood 0.020000 1.000 1.000
12002610 12 Peach, dried 0.020000 7.00 0 1.000
12002611 12 Peach, dried

- babyfood 0.020000 7.000 1.000 12002620 12 Peach, juice 0.020000 1.000 1.000 12002621 12 Peach, juice

- babyfood 0.020000 1.000 1.000

12002850 12 Plum 0.020000 1.000 1.000

12002851 12 Plum

- babyfood 0.020000 1.000 1.000 12002860 12 Plum, prune, fresh 0.020000 1.000 1.000 12002861 12 Plum, prune, fresh

- babyfood 0. 020000 1.000 1.000 12002870 12 Plum, prune, dried 0.020000 5.000 1.000 12002871 12 Plum, prune, dried

- babyfood 0.020000 5.000 1.000 12002880 12 Plum, prune, juice 0.020000 1.400 1.000

1200288 1 12 Plum, prune, juice

- babyfood 0.020000 1.400 1.000 13020570 13B Blueberry 0.020000 1.000 1.000 13020571 13B Blueberry

- babyfood 0.020000 1.000 1.000

13021360 13B Currant 0.020000 1.000 1.000
13021370 13B Currant, dried 0.020000 1.000 1.000 13021490 13B Elderberry 0.020000 1.000 1.000 13021740 13B Gooseberry 0.020000 1.000 1. 000 13021910 13B Huckleberry 0.020000 1.000 1.000

14000030 14 Almond 0.020000 1.000 1.000

14000031 14 Almond

- babyfood 0.020000 1.000 1.000
14000040 14 Almond, oil 0.020000 1.000 1.000
14000041 14 Almond, oil

- babyfood 0.020000 1.000 1.000

14000590 14 Brazil nut 0.020000 1.000 1.000

14000680 14 Butternut 0.02000 0 1.000 1.000

14000810 14 Cashew 0.020000 1.000 1.000

14000920 14 Chestnut 0.020000 1.000 1.000

14001550 14 Filbert 0.020000 1.000 1.000

14001560 14 Filbert, oil 0.020000 1.000 1.000 14001850 14 Hickory nut 0.020000 1.000 1.000

14002130 14 Macadamia nut 0.020000 1.000 1.000

14002690 14 Pecan 0.020000 1.000 1.000

14002820 14 Pistachio 0.020000 1.000 1.000

14003910 14 Walnut 0.020000 1.000 1.000
15001200 15 Corn, field, flour 0.020000 1.000 1.000
15001201 15 Corn, field, flour

- babyfood 0.020000 1.000 1.000
15001210 15 Corn, field, meal 0.020000 1.000 1.000
15001211 15 Corn, field, meal

- babyfood 0.020000 1.000 1.000
15001220 15 Corn, field, bra n 0.020000 1.000 1.000

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 12 of 18 15001230 15 Corn, field, starch 0.020000 1.000 1.000
15001231 15 Corn, field, starch

- babyfood 0.020000 1.000 1.000 15001240 15 Corn, field, syrup 0.020000 1 .000 1.000 15001241 15 Corn, field, syrup

- babyfood 0.020000 1.000 1.000
15001250 15 Corn, field, oil 0.020000 1.000 1.000
15001251 15 Corn, field, oil

- babyfood 0.020000 1.000 1.000

15004010 15 Whe at, grain 0.400000 1.000 1.000 new us

Full comment: new use 15004011 15 Wheat, grain

- babyfood 0.400000 1.000 1.000 new us

Full comment: new use
15004020 15 Wheat, flour 0.400000 1.000 1.000 new us

Full comment: new use
15004021 15 Wheat, flour

- babyfood 0.400000 1.000 1.000 new us

Full comment: new use 15004030 15 Wheat, germ 0.400000 1.000 1.000 new us

Full comment: new use
15004040 15 Wheat, bran 0.400000 1.000 1.000 new us

Full comment: new use
20001630 20 Flaxseed, oil 0.400000 1.000 1.000 new us

Full comme nt: new use 20003190 20 Rapeseed, oil 0.400000 1.000 1.000 new us

Full comment: new use 20003191 20 Rapeseed, oil

- babyfood 0.400000 1.000 1.000 new us

Full comment: new use

20003300 20 Saff lower, oil 0.500000 1.000 1.000 new us

Full comment: new use
20003301 20 Safflower, oil

- babyfood 0.500000 1.000 1.000 new us

Full comment: new use
20003640 20 Sunflower, seed 0.500000 1.000 1.000 new us

Full comment: new use
20003650 20 Sunflower, oil 0.500000 1.000 1.000 new us

Full comment: new use
20003651 20 Sunflower, oil

- babyfood 0.500000 1.000 1.000 new us

Full comment: new use

80001570 F Fish

- freshwater finfish 1.500000 1.000 1.000

80001580 F Fish

- freshwater finfish, farm ra 1.500000 1.000 1.000
86010000 O Water, direct, all sources 0.400000 1.000 1.00 0 aquati

Full comment: aquatic herbicide 86020000 O Water, indirect, all sources 0.400000 1.000 1.000 aquati

Full comment: aquatic herbicide 95000190 O Asparagus 0.020000 1.000 1.000

9500 1280 O Cottonseed, oil 0.020000 1.000 1.000
95001281 O Cottonseed, oil

- babyfood 0.020000 1.000 1.000 95001750 O Grape 0.020000 1.000 1.000 95001760 O Grape, juice 0.020000 1.200 1.000 95001761 O Grape, juice

- babyfood 0.020000 1.200 1.000 95001770 O Grape, leaves 0.020000 1.000 1.000 95001780 O Grape, raisin 0.020000 4.300 1.000 95001790 O Grape, wine and sherry 0.020000 1.000 1.000 95001880 O Hop 0.050000 1.000 1.000

95002630 O Peanut 0.020000 1.000 1.000
95002640 O Peanut, butter 0.020000 1.890 1.000
95002650 O Peanut, oil 0.020000 1.000 1.000 95002750 O Peppermint 0.040000 1.000 1.000 95002760 O Peppermint, oil 0.04 0000 1.000 1.000 95003520 O Spearmint 0.040000 1.000 1.000 95003530 O Spearmint, oil 0.040000 1.000 1.000 95003590 O Strawberry 0.070000 1.000 1.000

95003591 O Strawberry

- babyfood 0.070000 1.000 1.000 95003600 O Strawberry, juice 0.070000 1.000 1.000 95003601 O Strawberry, juice

- babyfood 0.070000 1.000 1.000 95003620 O Sugarcane, sugar 0.200000 1.000 1.000 95003621 O Sugarcane, sugar

- babyfood 0.200000 1.000 1.000 95003630 O Sugarcane, molasses 0.200000 1.000 1.000 95003631 O Sugarcane, molasses

- babyfood 0.200000 1.000 1.00 0

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 13 of 18 

## A ttachment 2: Acute Results File

U.S. Environmental Protection Agency Ver. 2.02

DEEM

- FCID ACUTE Analysis for FLUMIOXAZIN (1994

- 98 data) Residue file: Flumioxazin_acute.R98 Adju stment factor #2 NOT used. Analysis Date: 05

- 10

- 2012/14:34:36 Residue file dated: 05

- 10

- 2012/14:34:11/8
Daily totals for food and foodform consumption used. Run Comment: "Food + Drinking Water"

=========================================================== ====================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile
Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Females 13

- 49 yrs:

0.020349 67.83 0.032318 107.73 0.056892 189.64



## Attachment 3 : Chronic Food plus Water Residue Input File

Filename: C: \ Deemfcid \ Flumioxazin_chronic.R98 Chemical: Flumioxazin RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .03 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day
Date created/last modified: 05

- 10

- 2012/14:31:00/8 Program ver. 2.03
Comment: Food + Drinking Water

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------ ------------------------- ---------- ------ ------ ------- 01030150 1CD Arrowroot, flour 0.020000 1.000 1.000
01030151 1CD Arrowroot, flour

- babyfood 0.020000 1.000 1.000
01030170 1CD Artichoke, Jerusalem 0.020000 1.000 1.000

01030820 1CD Cassava 0.020000 1.000 1.000

01030821 1CD Cassava

- babyfood 0.020000 1.000 1.000
01031390 1CD Dasheen, corm 0.020000 1.000 1.000 01031660 1CD Ginger 0.020000 1.000 1.000 01031661 1CD Ginger

- babyfood 0.020000 1.000 1.000 01031670 1CD Ginger, dried 0.020000 1.000 1.000 01032960 1C Potato, chips 0.020000 1.000 1.000 01032970 1C Potato, dry (granules/ flakes) 0.020000 6.500 1.000 01032971 1C Potato, dry (granules/ flakes)

- b 0.020000 6.500 1.000
01032980 1C Potato, flour 0.020000 1. 000 1.000
01032981 1C Potato, flour

- babyfood 0.020000 1.000 1.000 01032990 1C Potato, tuber, w/peel 0.020000 1.000 1.000 01032991 1C Potato, tuber, w/peel

- babyfood 0.020000 1.000 1.000

01033000 1C Pota to, tuber, w/o peel 0.020000 1.000 1.000 01033001 1C Potato, tuber, w/o peel

- babyfood 0.020000 1.000 1.000 01033660 1CD Sweet potato 0.020000 1.000 1.000 01033661 1CD Sweet potato

- babyfood 0.020000 1.000 1.000
01033710 1CD Tanier, corm 0.020000 1.000 1.000

01033870 1CD Turmeric 0.020000 1.000 1.000
01034060 1CD Yam, true 0.020000 1.000 1.000

01034 070 1CD Yam bean 0.020000 1.000 1.000

03001640 3 Garlic 0.020000 1.000 1.000
03001650 3 Garlic, dried 0.020000 9.000 1.000
03001651 3 Garlic, dried

- babyfood 0.020000 1.000 1.000 03002370 3 Onion, dry bulb 0.020000 1.000 1.000 03002371 3 Onion, dry bulb

- babyfood 0.020000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.020000 9.000 1.000 03002381 3 Onion, dry bulb, dried

- babyfood 0.020000 9.000 1.000

04020760 4B Cardoon 0.020000 1.000 1.000

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 14 of 18 04020850 4B Celery 0.020000 1.000 1.000 04020851 4B Celery

- ba byfood 0.020000 1.000 1.000 04020860 4B Celery, juice 0.020000 1.000 1.000

04020870 4B Celtuce 0.020000 1.000 1.000
04021520 4B Fennel, Florence 0.020 000 1.000 1.000

04023220 4B Rhubarb 0.020000 1.000 1.000

04023670 4B Swiss chard 0.020000 1.000 1.000 06003470 6 Soybean, seed 0.020000 1.000 1.000

06003480 6 Soybean, flour 0.020000 1.000 1.000 06003481 6 Soybean, flour

- babyfood 0.020000 1.000 1.000 06003490 6 Soybean, soy milk 0.020000 1.000 1.000 06003491 6 Soybean, soy milk

- babyfood or in 0.020000 1.000 1.000 06003500 6 Soybean, oil 0.020000 1.000 1.000 06003501 6 Soybean, oil

- babyfood 0.020000 1.000 1.000
06030300 6C Bean, black, seed 0.070000 1.000 1.000 new us

Full comment: new use
06030320 6C Bean, broad, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030340 6C Bean, cowpea, seed 0.070000 1.000 1.000 new us

Full commen t: new use 06030350 6C Bean, great northern, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030360 6C Bean, kidney, seed 0.070000 1.000 1.000 new us

Full comment: new use
06030380 6C Bean, lima, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030390 6C Bean, mung, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030400 6C Bean, navy, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030410 6C Bean, pink, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030420 6C Bean, pinto, seed 0.070000 1.000 1.000 new u s

Full comment: new use 06030980 6C Chickpea, seed 0.070000 1.000 1.000 new us

Full comment: new use 06030981 6C Chickpea, seed

- babyfood 0.070000 1.000 1.000 new us

Full comment: new use 06030990 6C Chickpea, flour 0.070000 1.000 1.000 new us

Full comment: new use
06031820 6C Guar, seed 0.070000 1.000 1.000 new us

Full comment: new use
06031821 6C Guar, seed

- b abyfood 0.070000 1.000 1.000 new us

Full comment: new use
06032030 6C Lentil, seed 0.070000 1.000 1.000 new us

Full comment: new use 06032560 6C Pea, dry 0.07000 0 1.000 1.000 new us

Full comment: new use 06032561 6C Pea, dry

- babyfood 0.070000 1.000 1.000 new us

Full comment: new use 06032580 6C Pea, pigeon, seed 0.070000 1.000 1.000 new us

Full comment: new use 08001480 8 Eggplant 0.020000 1.000 1.000

08002340 8 Okra 0.020000 1.000 1.000 08002700 8 Pepper, bell 0.020000 1.000 1.000

0800 2701 8 Pepper, bell

- babyfood 0.020000 1.000 1.000 08002710 8 Pepper, bell, dried 0.020000 1.000 1.000 08002711 8 Pepper, bell, dried

- babyfood 0.020000 1.000 1.000 08002720 8 Pepper, nonbell 0.020000 1.000 1.000 08002721 8 Pepper, nonbell

- babyfood 0.020000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.020000 1.000 1.000

08003740 8 Tomatillo 0.020000 1.000 1.000

08003750 8 Tomato 0.020000 1.000 1.000

08003751 8 Tomato

- babyfood 0.020000 1.000 1.000 08003760 8 Tomato, paste 0.020000 1.000 1.000
08003761 8 Tomato, paste

- babyfood 0.020000 1.000 1.000

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 15 of 18 08003770 8 Tomato, puree 0.020000 1.000 1.000 08003771 8 Tomato, puree

- babyfood 0.020000 1.000 1.000
08003780 8 Tomato, dried 0.02 0000 1.000 1.000
08003781 8 Tomato, dried

- babyfood 0.020000 1.000 1.000 08003790 8 Tomato, juice 0.020000 1.000 1.000 09010750 9A Cantaloupe 0.030000 1.000 1.000

09010800 9A Casaba 0.030000 1.000 1.000 09011870 9A Honeydew melon 0.030000 1.000 1.000

09013990 9A Watermelon 0.030000 1.000 1.000 09014000 9A Watermelon, juice 0.030000 1.000 1.000 09020210 9B Balsam pear 0.030000 1.000 1.000 09020880 9B Chayote, fruit 0.030000 1.000 1.000 09021020 9B Chinese waxgourd 0.030000 1.000 1.00 0

09021350 9B Cucumber 0.030000 1.000 1.000 09023080 9B Pumpkin 0.030000 1.000 1.000 09023090 9B Pumpkin, seed 0.030000 1.000 1.000 09023560 9B Squash, summe r 0.030000 1.000 1.000 09023561 9B Squash, summer

- babyfood 0.030000 1.000 1.000 09023570 9B Squash, winter 0.030000 1.000 1.000 09023571 9B Squash, winter

- babyfood 0.030000 1.000 1.000 11000070 11 Apple, fruit with peel 0.020000 1.000 1.000 11000080 11 Apple, peeled fruit 0.020000 1.000 1.000 11000081 11 Apple, peeled fruit

- babyfood 0.020000 1.000 1.000

11000090 11 Apple, dried 0.020000 8.000 1.000 11000091 11 Apple, dried

- babyfood 0.020000 8.000 1.000 11000100 11 Apple, juice 0.020000 1.300 1.000 11000101 11 Apple, juice

- babyfood 0.020000 1.300 1.000 11000110 11 Apple, sauce 0.020000 1.000 1.000 11000111 11 Apple, sauce

- babyfood 0.020000 1.000 1.000 11001290 11 Crabapple 0.020000 1.000 1.000

1 1002100 11 Loquat 0.020000 1.000 1.000

11002660 11 Pear 0.020000 1.000 1.000

11002661 11 Pear

- babyfood 0.020000 1.000 1.000
11002670 11 Pear, dried 0.020000 6.250 1.000 11002680 11 Pear, juice 0.020000 1.000 1.000 11002681 11 Pear, juice

- babyfood 0.020000 1.000 1.000
11003100 11 Quince 0.020000 1.0 00 1.000 12000120 12 Apricot 0.020000 1.000 1.000 12000121 12 Apricot

- babyfood 0.020000 1.000 1.000 12000130 12 Apricot, dried 0.020000 6.000 1.000 12000140 12 Apric ot, juice 0.020000 1.000 1.000 12000141 12 Apricot, juice

- babyfood 0.020000 1.000 1.000 12000900 12 Cherry 0.020000 1.000 1.000 12000901 12 Cherry

- babyfood 0 .020000 1.000 1.000 12000910 12 Cherry, juice 0.020000 1.500 1.000 12000911 12 Cherry, juice

- babyfood 0.020000 1.500 1.000

12002300 12 Nectarine 0.020000 1.000 1.000

120026 00 12 Peach 0.020000 1.000 1.000

12002601 12 Peach

- babyfood 0.020000 1.000 1.000
12002610 12 Peach, dried 0.020000 7.000 1.000
12002611 12 Peach, dried

- babyfood 0.020000 7.000 1.000 12002620 12 Peach, juice 0.020000 1.000 1.000 12002621 12 Peach, juice

- babyfood 0.020000 1.000 1.000

12002850 12 Plum 0.020000 1.000 1 .000

12002851 12 Plum

- babyfood 0.020000 1.000 1.000 12002860 12 Plum, prune, fresh 0.020000 1.000 1.000 12002861 12 Plum, prune, fresh

- babyfood 0.020000 1.000 1.000 12002870 12 Plum, prun e, dried 0.020000 5.000 1.000 12002871 12 Plum, prune, dried

- babyfood 0.020000 5.000 1.000 12002880 12 Plum, prune, juice 0.020000 1.400 1.000 12002881 12 Plum, prune, juice

- babyfood 0.0200 00 1.400 1.000 13020570 13B Blueberry 0.020000 1.000 1.000 13020571 13B Blueberry

- babyfood 0.020000 1.000 1.000

13021360 13B Currant 0.020000 1.000 1.000

13021370 13 B Currant, dried 0.020000 1.000 1.000 13021490 13B Elderberry 0.020000 1.000 1.000

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 16 of 18 13021740 13B Gooseberry 0.020000 1.000 1.000 13021910 13B Huckleberry 0.020000 1.000 1.000

14000030 14 Almond 0.020000 1.000 1.000

14000031 14 Almond

- babyfood 0.020000 1.000 1.000
14000040 14 Almond, oil 0.020000 1.000 1.000
14000041 14 Almond, oil

- babyfood 0.020000 1.000 1.000

14000590 14 Brazil nut 0.020000 1.000 1.000

14000680 14 Butternut 0.020000 1.000 1.000

14000810 14 Cashew 0.020000 1.000 1.000

14000920 14 Chestnut 0.020000 1.000 1.000

14001550 14 Filbert 0.020000 1.000 1.000
14001560 14 Filbert, oil 0.020000 1.000 1.000 14001850 14 Hickory nut 0.020000 1.000 1.000

14002130 14 Macadamia nut 0.020000 1.000 1.000

14002690 14 Pecan 0.020000 1.000 1.000

14002820 14 Pi stachio 0.020000 1.000 1.000

14003910 14 Walnut 0.020000 1.000 1.000
15001200 15 Corn, field, flour 0.020000 1.000 1.000
15001201 15 Corn, field, flour

- babyfood 0.020000 1.000 1.000
15001210 15 Corn, field, meal 0.020000 1.000 1.000
15001211 15 Corn, field, meal

- babyfood 0.020000 1.000 1.000
15001220 15 Corn, field, bran 0.020000 1.000 1.000

150 01230 15 Corn, field, starch 0.020000 1.000 1.000
15001231 15 Corn, field, starch

- babyfood 0.020000 1.000 1.000 15001240 15 Corn, field, syrup 0.020000 1.000 1.000 15001241 15 Corn, field, syrup

- b abyfood 0.020000 1.000 1.000
15001250 15 Corn, field, oil 0.020000 1.000 1.000
15001251 15 Corn, field, oil

- babyfood 0.020000 1.000 1.000 15004010 15 Wheat, grain 0.400000 1.000 1.000 new us

Full comment: new use 15004011 15 Wheat, grain

- babyfood 0.400000 1.000 1.000 new us

Full comment: new use
15004020 15 Wheat, flour 0.400000 1.000 1.000 new us

Fu ll comment: new use
15004021 15 Wheat, flour

- babyfood 0.400000 1.000 1.000 new us

Full comment: new use 15004030 15 Wheat, germ 0.400000 1.000 1.000 new us

Full comment: new use

1500404 0 15 Wheat, bran 0.400000 1.000 1.000 new us

Full comment: new use
20001630 20 Flaxseed, oil 0.400000 1.000 1.000 new us

Full comment: new use 20003190 20 Rapeseed, oil 0.400000 1.000 1.000 new us

Full comment: new use 20003191 20 Rapeseed, oil

- babyfood 0.400000 1.000 1.000 new us

Full comment: new use
20003300 20 Safflower, oil 0.500000 1.000 1.000 new us

Full comment: new use
20003301 20 Safflower, oil

- babyfood 0.500000 1.000 1.000 new us

Full comment: new use
20003640 20 Sunflower, seed 0.500000 1.000 1.000 new us

Full comment: new use 20003650 20 Sunflower, oil 0.500000 1.000 1.000 new us

Full comment: new use
20003651 20 Sunflower, oil

- babyfood 0.500000 1.000 1.000 new us

Full comment: new use

80001570 F Fish

- freshwater finfish 1.500000 1.000 1.000

80001580 F Fish

- freshwater finfish, farm ra 1.500000 1.000 1.000 86010000 O Water, direct, all sources 0.142000 1.000 1.000 aquati

Full comment: aquatic herbic ide 86020000 O Water, indirect, all sources 0.142000 1.000 1.000 aquati

Full comment: aquatic herbicide 95000190 O Asparagus 0.020000 1.000 1.000
95001280 O Cottonseed, oil 0.0 20000 1.000 1.000
95001281 O Cottonseed, oil

- babyfood 0.020000 1.000 1.000 95001750 O Grape 0.020000 1.000 1.000

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 17 of 18 95001760 O Grape, juice 0.020000 1.200 1.000

95001761 O Grape, juice

- babyfood 0.020000 1.200 1.000 95001770 O Grape, leaves 0.020000 1.000 1.000 95001780 O Grape, raisin 0.020000 4.300 1.000 95001790 O Grape, wine and sherry 0.020000 1.000 1.000 95001880 O Hop 0.050000 1.000 1.000

95002630 O Peanut 0.020000 1.000 1.000
95002640 O Peanut, butter 0.020000 1.890 1.0 00
95002650 O Peanut, oil 0.020000 1.000 1.000 95002750 O Peppermint 0.040000 1.000 1.000 95002760 O Peppermint, oil 0.040000 1.000 1.000 95003520 O Spearmint 0.040000 1.000 1.000 95003530 O Spearmint, oil 0.040000 1.000 1.000 95003590 O Strawberry 0.070000 1.000 1.000 95003591 O Strawberry

- babyfood 0.070000 1.000 1.000 95003600 O Strawberry, juice 0.070000 1.000 1.000 95003601 O Strawberry, juice

- babyfood 0.070000 1.000 1.000 95003620 O Sugarcane, sugar 0.200000 1.000 1.000

95003621 O Sugarcane, sugar

- babyfood 0.200000 1.000 1.000 95003630 O Sugarcane, molasses 0.200000 1.000 1.000 95003631 O Sugarcane, molasses

- babyfood 0.200000 1.000 1.000



## A ttachment 4 : Chronic Results File

U .S. Environmental Protection Agency Ver. 2.00

DEEM

- FCID Chronic analysis for FLUMIOXAZIN (1994

- 98 data)

Residue file name: C: \ Deemfcid \ Flumioxazin_chronic.R98 Adjustment factor #2 NOT used. Analysis Date 05

- 10

- 2012/14:31:19 Residue file dated: 05

- 10

- 2012/14:31:00/8 Reference dose (RfD, Chronic) = .02 mg/kg bw/day
COMMENT 1: Food + Drinking Water

========================================================== ===================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------ - --------------- U.S. Population (total) 0.003976 19.9%

U.S. Population (spring season) 0.003966 19.8% U.S. Population (summer season) 0.004185 20.9%
U.S. Popu lation (autumn season) 0.003879 19.4% U.S. Population (winter season) 0.003872 19.4%

Northeast region 0.003734 18.7% Midwest region 0.004055 20.3% Southern region 0.003777 18.9% Western region 0.004427 22.1%

Hispanics 0.004329 21.6%

N on

- hispanic whites 0.003910 19.6%

Non

- hispanic blacks 0.003806 19.0%

Non

- hisp/non

- white/non

- black 0.004721 23.6%

All infants (< 1 year) 0.010863 54.3% Nursing infants 0.004109 20.5%

### Flumioxazin Dietary Exposu re and Risk Assessment DP Number: 401806

PC Code: 129034

______________________________________________________________________________________

Page 18 of 18 Non

- nursing infants 0.013427 67.1%

Children 1

- 6 yrs 0.006502 32.5%

Children 7

- 12 yrs 0.004260 21.3%

Females 13

- 19 (not preg or nursing) 0.002949 14.7% Females 20+ (not preg or nursing) 0.003687 18.4%

Females 13

- 50 yrs 0.003682 18.4% Females 13+ (preg/not nursing) 0.003716 18.6%
Females 13+ (nursing) 0.005116 25.6%

Males 13

- 19 yrs 0.003228 16.1% Males 20+ yrs 0.003462 17.3%

Seniors 55+ 0.003627 18.1%

Children 1

- 2 yrs 0.006844 34.2%

Children 3

- 5 yrs 0.006516 32.6%

Children 6

- 12 yrs 0.004490 22.5%

Youth 13

- 19 yrs 0.003101 15.5%

Adults 20

- 49 yrs 0.003565 17.8% Adults 50+ yrs 0.003627 18.1%

Females 13

- 49 yrs 0.003536 17.7%

--------------------------------- ----------------------------------------------



## Attachment 5: Chemical Structure of Flumioxazin and metabolites (482

- HA and APF).

Chemical Name Structure

Flumioxazin

2

- [7

- fluoro

- 3,4

- dihydro

- 3

- oxo

- 4

- (2

- propynyl)

- 2 H

- 1,4

- benzoxazin

- 6

- yl]

- 4,5,6,7

- tetrah ydro

- 1H

- isoindole

1,3(2H)

- dione

482

- HA

N

- [7

- fluoro

- 3

- oxo

- 4

- (2

- propynyl)

- 2H

- 1,4

- benzoxazin

- 6

- yl]

- 3,4,5,6

- tetrahydrophthalamic acid

APF

6

- amino

- 7

- fluoro

- 4

- (2

- propenyl)

- 2H

- 1,4

- benzoxazin

- 3(4H)

- one