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                                                                    EXHIBIT 10.5

                  FORM OF NON-QUALIFIED STOCK OPTION AGREEMENT

                                    DIRECTOR/EMPLOYEE NON-QUALIFIED STOCK OPTION
                                                            (AS AMENDED 4/22/04)

                            OSI PHARMACEUTICALS, INC.

                           NON-QUALIFIED STOCK OPTION
                    AMENDED AND RESTATED STOCK INCENTIVE PLAN

      THIS NON-QUALIFIED STOCK OPTION is granted as of _______________by OSI
PHARMACEUTICALS, INC., a Delaware corporation (the "Company"), to
_______________________ (the "Optionee"), an employee of the Company.

      Pursuant to the OSI Pharmaceuticals, Inc. Amended and Restated Stock
Incentive Plan (the "Plan"), a copy of which has been provided to Optionee as of
the date hereof, the Optionee was granted a non-qualified stock option to
purchase shares of the Company's common stock, par value $.01 per share (the
"Common Stock"), as hereinafter set forth. The option granted herein is not
intended to qualify as an "incentive stock option" as defined in Section 422 of
the Internal Revenue Code of 1986, as amended.

                              W I T N E S S E T H:

      1. Grant. Effective as of __________________ (the "Date of Grant"), the
Company granted to the Optionee an option (the "Option") to purchase on the
terms and conditions set forth herein and in the Plan all or any part of an
aggregate of _____ shares of Common Stock (the "Option Shares"), at the purchase
price of $_____ per share (the "Option Price").

      2. Vesting. The Optionee shall have the cumulative right to exercise the
Option, and the Option is only exercisable, as follows:

            (a) The Option shall not be exercisable prior to the first annual
anniversary of the Date of Grant (the "First Anniversary");

            (b) Beginning on the First Anniversary, one third of the Option
Shares shall become exercisable, with any fractional number of Option Shares
that would otherwise become exercisable as of that date rounded to a whole
integer as determined in the discretion of the Committee.

            (c) The remaining two-thirds of the Option Shares shall become
exercisable ratably as of each monthly anniversary of the Date of Grant
beginning with the 12th monthly anniversary of the Date of Grant and ending on
the 36th monthly anniversary of the Date of Grant, with any fractional number of
Option Shares that would otherwise become exercisable as

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of any such monthly anniversary rounded to a whole integer as determined in the
discretion of the Committee.

      3. Term. The Option shall terminate in all events at 5:00 p.m. (local New
York, New York time) on [INSERT DATE IMMEDIATELY PRIOR TO TENTH ANNIVERSARY OF
DATE OF GRANT] (the "Termination Date"), unless sooner terminated as provided in
Subparagraphs (a) or (b) below.

            (a) Termination of Employment or Service. The Option shall terminate
and shall no longer be exercisable ninety (90) days after the Optionee's
employment (or service as an officer or consultant) with the Company and any
parent or subsidiary of the Company terminates, unless such termination of
employment or service was caused by the Optionee's death or Retirement (as
defined in the Plan). The death or Retirement of the Optionee shall not affect
the remaining term of the Option. Following a termination of employment or
service, the Optionee (or the Optionee's heirs or personal representatives if
Optionee is deceased) may, during the remaining term of the Option, purchase any
remaining Option Shares which could have been purchased on the date Optionee's
employment or service was terminated, but may not purchase any Option Shares
which would otherwise have first become purchasable following such termination
of employment or service.

            (b) Sale or Reorganization. As provided in Section 6(i) of the Plan,
if the Company is merged or consolidated with another corporation, or if the
property or stock of the Company is acquired by another corporation, or if there
is a separation, reorganization or liquidation of the Company, the Board of
Directors of the Company may, in its discretion, give Optionee a written notice
that the Option will terminate thirty (30) days after the date of such written
notice. In any such case, the Option will become immediately exercisable in
full, notwithstanding Paragraph 2 above.

      4. Method of Exercise and Payment.

            (a) Method of Exercise. The Option may be exercised by delivering to
the Company at its principal office, directed to the attention of the Secretary,
(i) a written notice of exercise in the form attached hereto as Exhibit "A",
signed by the person entitled to exercise the Option, stating the number of
Option Shares such person then elects to purchase hereunder; (ii) payment of the
aggregate Option Price of the Option Shares being purchased; and (iii) if the
Option is being exercised by a person other than the Optionee, evidence
satisfactory to the Company that such person has a right to exercise the Option.
Upon due exercise of the Option and payment of the Option Price, the Company
shall deliver to the Optionee or other person entitled to exercise the Option a
certificate for the Option Shares being purchased. The Company shall be
responsible for any stock transfer tax due upon the purchase or issuance of the
Option Shares.

            (b) Medium of Payment. Optionee may pay for Option Shares (i) in
cash, (ii) by certified check payable to the order of the Company, or (iii) by a
combination of the foregoing. Furthermore, subject to the restrictions described
below, payment may be made all or in part in shares of the Common Stock of the
Company held by the Optionee. If payment is

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made in whole or in part in shares of Common Stock, then the Optionee shall
deliver to the Company certificates registered in the name of such Optionee
representing shares of Common Stock legally and beneficially owned by such
Optionee, free of all liens, claims and encumbrances of every kind and having a
Fair Market Value on the date of delivery of such Common Stock that is not less
than the product of the Option Price and the number of Option Shares to be
purchased with Common Stock, accompanied by stock powers duly endorsed in blank
by the record holder of the shares represented by such certificates. If payment
is made with Common Stock, the Fair Market Value of such Common Stock shall be
determined as provided in Section 6(k) of the Plan, without regard to the last
sentence of such section. Notwithstanding the foregoing, the Board of Directors,
in its sole discretion, may refuse to accept shares of Common Stock in payment
of the Option Price. In that event, any certificates representing shares of
Common Stock which were delivered to the Company shall be returned to the
Optionee with notice of the refusal of the Board of Directors to accept such
shares in payment of the Option Price.

            (c) Taxes. It shall be a condition to the performance of the
Company's obligation to issue or transfer Option Shares upon the exercise of the
Option that the Optionee remit to the Company an amount sufficient to satisfy
any federal, state and/or local tax withholding requirements arising in
connection with the exercise of the Option or the issuance of Option Shares,
other than stock transfer taxes. If the Company for any reason does not require
the Optionee to make a payment sufficient to satisfy such withholding
requirements, any tax withholding payments made by the Company to any federal,
state or local tax authority with respect to the exercise of the Option shall
constitute a personal obligation of the Optionee to the Company, payable upon
demand or, at the option of the Company, by deduction from future compensation
payable to the Optionee.

            (d) Partial Exercise. To the extent otherwise exercisable, the
Option may be exercised in whole or in part, except that the Option may in no
event be exercised with respect to fractional shares.

      5. Transfers. The Option is not transferable by the Optionee otherwise
than by will or pursuant to the laws of descent and distribution in the event of
the Optionee's death, in which event the Option may be exercised by the heirs or
legal representatives of the Optionee. The Option may be exercised during the
lifetime of the Optionee only by the Optionee. Any attempt at assignment,
transfer, pledge or disposition of the Option contrary to the provisions hereof
or the levy of any execution, attachment or similar process upon the Option
shall be null and void and without effect. Any exercise of the Option by a
person other than the Optionee shall be accompanied by appropriate proofs of the
right of such person to exercise the Option.

      6. Adjustments on Changes in Common Stock. In the event that dividends
payable in Common Stock during any fiscal year of the Company exceed in the
aggregate five percent (5%) of the Common Stock issued and outstanding at the
beginning of the year, or in the event there is during any fiscal year of the
Company one or more splits, subdivisions or combinations of shares of Common
Stock resulting in an increase or decrease by more than five percent (5%) of the
shares of Common Stock outstanding at the beginning of the year, the number of
Option Shares deliverable upon the exercise thereafter of the Option shall be
increased or decreased

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proportionately, as the case may be, without change in the aggregate purchase
price payable upon exercise of the Option. Common Stock dividends, splits,
subdivisions or combinations during any fiscal year which do not exceed in the
aggregate five percent (5%) of the Common Stock issued and outstanding at the
beginning of such year shall not result in any adjustment under the Option. All
adjustments shall be made as of the day such action necessitating such
adjustment becomes effective.

      7. Legal Requirements.

            (a) Listing Requirements. If at any time the Board of Directors
shall determine, in its discretion, that the listing, registration, or
qualification of any of the Option Shares upon any securities exchange or under
any state or federal law, or the consent or approval of any governmental
regulatory body, is necessary or desirable as a condition of, or in connection
with, the granting of the Option or the issue, transfer or purchase of Option
Shares hereunder, the Option may not be exercised in whole or in part unless
such listing, registration, qualification, consent, or approval shall have been
effected or obtained free of any conditions not acceptable to the Board of
Directors.

            (b) Securities Laws. The Company shall not be obligated to sell or
issue any Option Shares in any manner in contravention of the Securities Act of
1933, as amended, or any state securities law. The Board of Directors or the
Committee may, at any time, require, as a condition to the exercise of the
Option, the representation or agreement of the Optionee to the effect that the
Option Shares issuable upon exercise of the Option are acquired by the Optionee
for investment purposes and not with a view to the resale or distribution
thereof, and may require such other representations and documents as may be
required to comply with applicable securities laws.

      8. Administration. The Option has been granted pursuant to, and is subject
to the terms and provisions of, the Plan. All terms used herein which are
defined in the Plan and not otherwise defined herein shall have the same
meanings as in the Plan. To the extent that the provisions hereof conflict with
those of the Plan, the provisions of the Plan shall control. All decisions or
interpretations made by the Committee (as designated under the Plan) regarding
any issue or question arising under the Option or the Plan shall be final,
binding and conclusive on the Company and the Optionee.

      9. Rights as Stockholder. The Optionee shall have none of the rights of a
stockholder with respect to the Option Shares unless and until such Option
Shares shall be issued to the Optionee upon the exercise of the Option. Except
as provided in Paragraph 6 above, no adjustments shall be made for dividends or
other rights for which the record date is prior to the date the stock
certificate is issued.

      10. Continued Employment or Service. Nothing contained herein or in the
Plan shall confer any right to continue in the employ or service of the Company
or any parent or subsidiary of the Company or interfere in any way with the
right of the Company or any parent or subsidiary of the Company to terminate the
employment, services, responsibilities or duties of the Optionee at any time for
any reason whatsoever.

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      11. Sale of Option Shares. Unless otherwise provided by the Committee, no
Option Shares acquired upon exercise of the Option may be sold or otherwise
disposed of by the Optionee within six months from the Date of Grant.

      12. Notices. Any notice to be given to the Company hereunder shall be
delivered personally to the Secretary of the Company or mailed or delivered to
the Company at its principal executive office, addressed to the attention of the
Secretary, and any notice to be given to the Optionee hereunder shall be
delivered personally or mailed or delivered to the Optionee at the address then
appearing on the records of the Company. Such addresses may be changed at any
time by notice from one party to the other. Notices given hereunder shall be in
writing, and shall be deemed to have been duly given upon delivery thereof, if
personally delivered, or three days after being deposited in the United States
mail, registered or certified mail, properly addressed, with proper postage and
fees prepaid, or one day after being deposited with a delivery service
guaranteeing overnight delivery, properly addressed, with fees paid by the
sender.

      13. Binding Effect. This agreement shall be binding upon and inure to the
benefit of the parties hereto, including the successors and assigns of the
Company and the heirs and personal representatives of the Optionee.

      IN WITNESS WHEREOF, the Company has granted this Option as of the day and
year first above written.

                                OSI PHARMACEUTICALS, INC.

                                ________________________________
                                Name: Robert L. Van Nostrand
                                Title: Vice President and
                                       Chief Financial Officer

                                ACCEPTED BY (OPTIONEE):

                                ________________________________
                                Name:

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