Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 1 of 15

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND

 POLLUTION PREVENTION

MEMORANDUM

Date: 30-APR-2012 

SUBJECT: Cyazofamid Acute and Chronic Aggregate Dietary (Food and Drinking 

Water) Exposure and Risk Assessments for the Section 3 Registration 

Action on Basil, Succulent Beans, the Fruiting Vegetable Group 8-10, the 

Leafy Greens Subgroup 4A, and the Tuberous and Corm Vegetable 

Subgroup 1C. 

PC Code: 085651 DP Barcode: D397214

Decision No.: 456373 Registration No.: 71512-3

Petition No.: 1E7929 Regulatory Action: Section 3 Registration

Risk Assessment Type: NA Case No.: None

TXR No.: NA CAS No.: 120116-88-3

MRID No.: None 40 CFR: 180.601

FROM: Nancy Dodd, Chemist

Registration Action Branch III (RAB3)

Health Effects Division (HED; 7509P)

THROUGH: Thomas Bloem, Chemist

William Cutchin, Chemist

Dietary Exposure Science Advisory Council (DESAC)

HED (7509P)

and

Paula Deschamp, Branch Chief

RAB3/HED (7509P)

TO: Nancy Tsaur, Chemist

RAB3/HED (7509P)

and

Barbara Madden/Laura Nollen, RM #5

Risk Integration, Minor Use and Emergency Response Branch

Registration Division (7505P)
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 2 of 15

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk 

assessments were conducted using the Dietary Exposure Evaluation Model DEEMFCIDTM, Version 2.03 which uses food consumption data from the U.S. Department of 

Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-

1996 and 1998. The analyses were performed to support Section 3 requests for uses on

basil, succulent beans, the fruiting vegetable group 8-10, the leafy greens subgroup 4A, 

and the tuberous and corm vegetable subgroup 1C.

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

The conservative acute dietary (food + drinking water) exposure assessment was 

performed for females 13-49 years old only, since an acute endpoint of concern was not 

identified for the general population. The acute dietary (food and drinking water) 

exposure assessment is conservative, i.e., based on the assumption that residues in all 

crops are at the tolerance levels and that 100% of the crops are treated (100% CT). All 

processing factors were set to 1x, based on the results of processing studies 

demonstrating that residues of cyazofamid in processed commodities would not exceed 

the level in the raw agricultural commodity (RAC) tolerances, except that default 

processing factors were used for dried tomatoes and tomato juice since those 

commodities are not required to be analyzed in processing studies. The acute estimated 

drinking water concentration (EDWC) of 136.2 ppb was modeled using Tier 2 

PRZM/EXAMS (Pesticide Root Zone Model/Exposure Analysis Modeling System) for 

residues in surface water from use on turf and ornamentals, which yielded the highest 

acute EDWC considering all registered/proposed uses. The acute dietary risk assessment 

shows that the acute dietary risk estimates are below HED’s level of concern (i.e., <100% 

of the acute population adjusted dose (aPAD)). The acute dietary risk estimate for 

females 13-49 years old at the 95th percentile of exposure was 2.5% of the aPAD. 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

The chronic dietary (food and drinking water) exposure assessment is conservative, i.e., 

based on the assumption that residues in all crops are at the tolerance levels and that 

100% of the crops are treated (100% CT). All processing factors were set to 1x, based on 

the results of processing studies demonstrating that residues of cyazofamid in processed 

commodities would not exceed the level in the raw agricultural commodity (RAC) 

tolerances, except that default processing factors were used for dried tomatoes and 

tomato juice since those commodities are not required to be analyzed in processing 

studies. The chronic EDWC of 133.5 ppb was modeled using Tier 2 PRZM/EXAMS 

(Pesticide Root Zone Model/Exposure Analysis Modeling System) for residues in surface 

water from use on turf and ornamentals, which yielded the highest chronic EDWC 

considering all registered/proposed uses. The chronic dietary risk assessment shows that 

the chronic dietary risk estimates are below HED’s level of concern (i.e., <100% of the 

chronic population adjusted dose (cPAD)). For the general U.S. population, the exposure 

for food and drinking water utilized <1% of the cPAD. The chronic dietary risk estimate 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 3 of 15

for the highest reported exposed population subgroup, children (1-2 years old), utilized

1.5% of the cPAD. 

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

A cancer dietary risk assessment was not conducted since cyazofamid is classified as “not 

likely to be carcinogenic to humans.”

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population adjusted dose (PAD). 

The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by

the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary

risk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk 

exceeds one in one million. References which discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: “Available 

Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, 

web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see 

SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for cyazofamid was conducted by Roger Chesser 

(25-MAY-2010, DP# D376585).

II. Residue Information

Tolerances: Permanent tolerances are established in 40 CFR §180.601 on various raw 

agricultural commodities (RACs) at levels ranging from 0.02 ppm on potato to 12.0 ppm 

on turnip greens and the Brassica leafy greens subgroup 5B. A tolerance with regional 

registration is established on grape at 1.5 ppm. Time-limited tolerances under Section 18 

have been established on dried basil at 144 ppm and fresh basil at 12 ppm; these 

tolerances will expire on 12/31/14. No tolerances have been established on livestock 

commodities. Compliance with all tolerances specified in 40 CFR §180.601 is to be 

determined by measuring only the sum of cyazofamid and its metabolite CCIM, 

calculated as the stoichiometric equivalent of cyazofamid. 

Residues of Concern: The HED Metabolism Assessment Review Committee (MARC) 

determined in a meeting on 2/18/04 that the residues of concern for risk assessment are 

parent and CCIM in plants, parent only in rotational crops, and parent, CCIM, CCIMAM, and CTCA in water. For livestock commodities, the proposed and established uses 

fall under 40 CFR §180.6(a)(3), i.e., there is no reasonable expectation of finite residues 

in livestock commodities.
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 4 of 15

Residue Data Used for Acute and Chronic Assessments

The conservative acute and chronic analyses assumed that cyazofamid residues are 

present in/on all proposed/registered food commodities at tolerance levels and that 100% 

of all commodities are treated. Adequate processing data are available for grapes (MRID 

45409028), tomatoes (MRID 45409031), and potatoes (MRID 45409033 and MRID 

46537730). The results of these studies indicate that combined residues of cyazofamid 

and CCIM in processed commodities are not expected to exceed the tolerances on the raw 

agricultural commodities. Therefore, processing factors were set to 1x, except that 

default processing factors were used for dried tomatoes and tomato juice since those 

commodities are not required to be analyzed in processing studies. The food residue data 

used in the acute and chronic analyses are summarized in Table 1 below.

Table 1. Residue Data Used in the Acute and Chronic Dietary Analyses for Cyazofamid.1

Commodity Recommended 

Tolerance (ppm)

Percent Crop 

Treated

Processing Factors

Bean, succulent 0.5

100 NA2

Bean, succulent, shelled 0.08

Leafy greens subgroup 4A 10

Basil, fresh leaves 30

Basil, dried leaves 1443

Vegetable, tuberous and corm, 

subgroup 1C

0.02

Vegetable, fruiting, group 8-10 0.9 Dried tomato 14.3

Tomato juice 1.5

1 Table 1 includes proposed crops/crop groups only.

2 NA = not applicable.

3 The time-limited tolerance of 144 ppm, which is established under the Section 18, was used for dried basil 

leaves instead of the recommended Section 3 tolerance of 90 ppm.

III. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: 

“Estimated Drinking Water Concentrations of Cyazofamid and its Degradates of Concern 

CCIM, CCIM-AM and CTCA, for Use in Human Health Risk Assessment: IR-4 Petition 

for the Use on Succulent Beans, Shelled Beans, Leafy Greens Subgroup 4A, Basil (Fresh 

and Dried Leaves), Tuberous and Corm Vegetables Subgroup 1C, and Fruiting 

Vegetables Group 8-10” (J. Meléndez, 10-FEB-2012, DP# D396052) and incorporated 

directly into this dietary assessment. Water residues were incorporated in the DEEMFCID into the food categories “water, direct, all sources” and “water, indirect, all 

sources.” 

As shown in Table 2 below, the acute value of 136.2 ppb and the non-cancer chronic 

value of 133.5 ppb were the EDWCs which were directly entered into the exposure 

model to assess the contributions from drinking water. These EDWCs were modeled 

using Tier 2 PRZM/EXAMS (Pesticide Root Zone Model/Exposure Analysis Modeling 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 5 of 15

System) for residues in surface water from use on turf and ornamentals, which had the 

highest seasonal rates among the proposed and registered uses. Acute and chronic 

EDWCs in ground water as modeled by Tier 1 SCI-GROW (Screening Concentration in 

Ground Water) were lower (2.18 ppb).

 

Table 2. Surface/Ground Water EDWCs for Cyazofamid and its Major Degradates.

Scenario Chemical

Surface water EDWCs (ppb)

Ground water 

EDWC (ppb)

Acute

(1-in-10 yr. peak)

Chronic

(1-in-10 yr. mean)

1

st

 Scenario Parent 14.362 0.377 0.01180

2

nd

 Scenario 

CCIM 17.106 12.094 0.00061

CCIM-AM 6.699 6.312 0.00270

3

rd

 Scenario CTCA 136.242 133.458 2.18000

The model and its description are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 

IV. DEEM-FCIDTM Program and Consumption Information

Cyazofamid acute and chronic dietary exposure assessments were conducted using the 

Dietary Exposure Evaluation Model software with the Food Commodity Intake Database 

DEEM-FCIDTM, Version 2.03 which incorporates consumption data from USDA’s 

Continuing Surveys of Food Intakes by Individuals (CSFII), 1994-1996 and 1998. The 

1994-96, 98 data are based on the reported consumption of more than 20,000 individuals 

over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked 

to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population 

subgroups, but for acute exposure assessment are retained as individual consumption 

events. Based on analysis of the 1994-96, 98 CSFII consumption data, which took into 

account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-

19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cPAD. This procedure is performed for each 

population subgroup.
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 6 of 15

For acute exposure assessments, individual one-day food consumption data are used on 

an individual-by-individual basis. The reported consumption amounts of each food item 

can be multiplied by a residue point estimate and summed to obtain a total daily pesticide 

exposure for a deterministic exposure assessment, or “matched” in multiple random 

pairings with residue values and then summed in a probabilistic assessment. The 

resulting distribution of exposures is expressed as a percentage of the aPAD on both a 

user (i.e., only those who reported eating relevant commodities/food forms) and a percapita (i.e., those who reported eating the relevant commodities as well as those who did 

not) basis. In accordance with HED policy, per capita exposure and risk are reported for 

all tiers of analysis. However, for tiers 1 and 2, any significant differences in user vs. per 

capita exposure and risk are specifically identified and noted in the risk assessment.

V. Toxicological Information

The risk assessment team selected endpoints that were selected previously (Ghazi 

Dannan, 15-APR-2004, TXR# 0052428, Cyazofamid [IKF-916] – Report of the Hazard 

Identification Assessment Review Committee).

The HED cyazofamid risk assessment team has recommended that the FQPA Safety 

Factor be reduced to 1X (DP# D356837, N. Tsaur, 20-MAY-2009; DP# D370671, N. 

Tsaur, 7-APR-2010). In brief, the toxicology database is adequate for the purpose of 

characterization of potential pre- and postnatal risks to infants and children. The concern 

is low for the quantitative susceptibility seen in the rat developmental toxicity study and 

there are no residual uncertainties. There were no indications of pre-and/or postnatal 

toxicity and no residual uncertainties from the rabbit developmental study or the rat twogeneration reproduction study. Although a subchronic neurotoxicity study is not 

available, the acute neurotoxicity study showed no neurotoxic effects. Neurotoxicity and 

immunotoxicity were not demonstrated in the available studies. The dietary (food and 

water) and residential exposure assessments are conservative and are not likely to 

underestimate the potential exposures.
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 7 of 15

Table 3. Summary of Toxicological Doses and Endpoints for Cyazofamid for Use in Dietary 

Exposure Risk Assessments.

Exposure/

Scenario

Point of 

Departure

(PoD)

Uncertainty/

FQPA Safety 

Factors

RfD, PAD, 

Level of 

Concern 

Study and Toxicological Effects

Acute Dietary 

(General 

Population, 

including 

Infants and 

Children)

No adverse effects were observed which could be attributed to a single-dose exposure 

for the general population.

Acute Dietary

(Females 13-

49 years of 

age)

NOAEL = 

100 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 

1X

Acute RfD = 

1.0 mg/kg/day

aPAD = 1.0 

mg/kg/day

Rat Prenatal Developmental Toxicity 

(MRID 45408933)

LOAEL = 1,000 mg/kg/day based on

developmental toxicity findings of 

increased incidence of bent ribs.

Chronic 

Dietary (All 

Populations)

NOAEL= 

94.8 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 

1X

Chronic RfD = 

0.95 mg/kg/day

cPAD = 0.95 

mg/kg/day

18-Month Mouse Oral 

Carcinogenicity (MRID 45408932)

LOAEL = 985 mg/kg/day based on 

increased skin lesions.

Cancer (oral, 

dermal, 

inhalation)

Classification: “Not likely to be Carcinogenic to Humans” based on the absence of 

significant tumor increases in two adequate rodent carcinogenicity studies.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response 

data and used to mark the beginning of extrapolation to determine risk associated with lower 

environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest 

observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from animal to human 

(interspecies). UFH = potential variation in sensitivity among members of the human population 

(intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). 

RfD = reference dose. N/A = not applicable.

VI. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure 

of the U.S. population and various population subgroups. The results reported in Table 4

are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, 

children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years old. 

Cancer risk is determined for the general U.S. population only.

Results of Acute Dietary (Food and Drinking Water) Exposure Analysis

An acute dietary (food + drinking water) exposure assessment was performed for females 

13-49 years old only, since an acute endpoint of concern was not identified for the 

general population. 

The acute dietary (food and drinking water) exposure assessment is conservative, i.e., 

based on the assumption that residues in all crops are at the tolerance levels and that 

100% of the crops are treated (100% CT). The acute dietary risk assessment shows that 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 8 of 15

the acute dietary risk estimates are below HED’s level of concern (i.e., <100% of the 

acute population adjusted dose (cPAD)). The acute dietary risk estimate for females 13-

49 years old at the 95th percentile of exposure was 2.5% of the aPAD. The results of the 

acute dietary exposure analysis are reported in Table 4 below. 

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The chronic dietary (food and drinking water) exposure assessment is conservative, i.e., 

based on the assumption that residues in all crops are at the tolerance levels and that 

100% of the crops are treated (100% CT). The chronic dietary risk assessment shows 

that the chronic dietary risk estimates are below HED’s level of concern (i.e., <100% of 

the chronic population adjusted dose (cPAD)). For the general U.S. population, the 

exposure for food and drinking water utilized <1% of the cPAD. The chronic dietary risk 

estimate for the highest reported exposed population subgroup, children (1-2 years old), 

was 1.5% of the cPAD. The results of the chronic dietary exposure analysis are reported 

in Table 4 below. 

Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Cyazofamid.

Population Subgroup

Acute Dietary

(95th Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population

NA1 NA

0.008157 <1%

All Infants (< 1 year old) 0.012989 1.4

N/A N/A

Children 1-2 years old 0.014334 1.5

Children 3-5 years old 0.012279 1.3

Children 6-12 years old 0.008139 <1%

Youth 13-19 years old 0.006274 <1%

Adults 20-49 years old 0.007733 <1%

Adults 50+ years old 0.007855 <1%

Females 13-49 years old 0.024799 2.5 0.007725 <1%

1 NA = Not Applicable

VII. Characterization of Inputs/Outputs

The acute and chronic dietary exposure and risk estimates are conservative since they

assume that 100% of the crops are treated with cyazofamid and that residues are present 

at tolerance levels. In addition, EDWCs were based on screening level estimates 

generated by the PRZM-EXAMS model. Dietary exposure estimates could be refined 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 9 of 15

through the use of anticipated residues and percent crop treated data, as well as refined 

estimated drinking water concentrations. However, since estimated exposures and risks 

using conservative assumptions are well below the Agency’s level of concern, such 

refinement is not warranted.

VIII. Conclusions

These conservative dietary exposure analyses using DEEM-FCIDTM indicate that acute 

and chronic dietary exposures to cyazofamid from food and drinking water are well 

below the Agency’s level of concern. Both assessments were conservative, i.e., the 

assessments assumed that residues in all crops were at tolerance levels and that 100% of 

the crops were treated. An acute endpoint was not identified for the general U.S. 

population. The estimated acute exposure of females 13-49 years old, the only

population subgroup of concern for acute exposure, represents 2.5% of the aPAD at the 

95th percentile of exposure. Estimated chronic dietary exposures are <1% of the cPAD 

for the general U.S. population and 1.5% of the cPAD for the highest reported exposed 

population subgroup, children (1-2 years old).

IX. List of Attachments

• Acute Food plus Water Residue Input File.

• Acute Results File.

• Chronic Food Residue Input File.

• Chronic Results File.

cc: N. Dodd (RAB3/HED); N. Tsaur (RAB3/HED)
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 10 of 15

Attachment 1. Acute Food plus Water Residue Input File

Filename: C:\Documents and Settings\NDODD\My Documents\Deemfcidndodd\Cyazofamd\acute

cyazofamid food+water 043012.R98

Chemical: cyazofamid

RfD(Chronic): .95 mg/kg bw/day NOEL(Chronic): 94.8 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day

Date created/last modified: 04-30-2012/13:35:46/8 Program ver. 2.03

Comment: Drinking water using turf & ornamentals inc. parent, CCIM, CCIM-AM

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

01010780 1AB Carrot 0.090000 1.000 1.000 

01010781 1AB Carrot-babyfood 0.090000 1.000 1.000 

01010790 1AB Carrot, juice 0.090000 1.000 1.000 

01030150 1CD Arrowroot, flour 0.020000 1.000 1.000 

01030151 1CD Arrowroot, flour-babyfood 0.020000 1.000 1.000 

01030170 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 

01030820 1CD Cassava 0.020000 1.000 1.000 

01030821 1CD Cassava-babyfood 0.020000 1.000 1.000 

01031390 1CD Dasheen, corm 0.020000 1.000 1.000 

01031660 1CD Ginger 0.020000 1.000 1.000 

01031661 1CD Ginger-babyfood 0.020000 1.000 1.000 

01031670 1CD Ginger, dried 0.020000 1.000 1.000 

01032960 1C Potato, chips 0.020000 1.000 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.020000 1.000 1.000 

01032980 1C Potato, flour 0.020000 1.000 1.000 

01032981 1C Potato, flour-babyfood 0.020000 1.000 1.000 

01032990 1C Potato, tuber, w/peel 0.020000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 

01033660 1CD Sweet potato 0.020000 1.000 1.000 

01033661 1CD Sweet potato-babyfood 0.020000 1.000 1.000 

01033710 1CD Tanier, corm 0.020000 1.000 1.000 

01033870 1CD Turmeric 0.020000 1.000 1.000 

01034060 1CD Yam, true 0.020000 1.000 1.000 

01034070 1CD Yam bean 0.020000 1.000 1.000 

04010050 4A Amaranth, leafy 10.000000 1.000 1.000 

04010180 4A Arugula 10.000000 1.000 1.000 

04011040 4A Chrysanthemum, garland 10.000000 1.000 1.000 

04011330 4A Cress, garden 10.000000 1.000 1.000 

04011340 4A Cress, upland 10.000000 1.000 1.000 

04011380 4A Dandelion, leaves 10.000000 1.000 1.000 

04011500 4A Endive 10.000000 1.000 1.000 

04012040 4A Lettuce, head 10.000000 1.000 1.000 

04012050 4A Lettuce, leaf 10.000000 1.000 1.000 

04012480 4A Parsley, leaves 10.000000 1.000 1.000 

04013130 4A Radicchio 10.000000 1.000 1.000 

04013550 4A Spinach 10.000000 1.000 1.000 

04013551 4A Spinach-babyfood 10.000000 1.000 1.000 

05010610 5A Broccoli 1.200000 1.000 1.000 

05010611 5A Broccoli-babyfood 1.200000 1.000 1.000 

05010620 5A Broccoli, Chinese 1.200000 1.000 1.000 

05010640 5A Brussels sprouts 1.200000 1.000 1.000 

05010690 5A Cabbage 1.200000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 

05010830 5A Cauliflower 1.200000 1.000 1.000 

05011960 5A Kohlrabi 1.200000 1.000 1.000 

05020630 5B Broccoli raab 12.000000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 

05021170 5B Collards 12.000000 1.000 1.000 

05021940 5B Kale 12.000000 1.000 1.000 

05022290 5B Mustard greens 12.000000 1.000 1.000 

05023180 5B Rape greens 12.000000 1.000 1.000 

05023890 5B Turnip, greens 12.000000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 11 of 15

06010430 6A Bean, snap, succulent 0.500000 1.000 1.000 

06010431 6A Bean, snap, succulent-babyfood 0.500000 1.000 1.000 

06020310 6B Bean, broad, succulent 0.080000 1.000 1.000 

06020330 6B Bean, cowpea, succulent 0.080000 1.000 1.000 

06020370 6B Bean, lima, succulent 0.080000 1.000 1.000 

08001480 8 Eggplant 0.900000 1.000 1.000 

08002340 8 Okra 0.900000 1.000 1.000 

08002700 8 Pepper, bell 0.900000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.900000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.900000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.900000 1.000 1.000 

08002720 8 Pepper, nonbell 0.900000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.900000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.900000 1.000 1.000 

08003740 8 Tomatillo 0.900000 1.000 1.000 

08003750 8 Tomato 0.900000 1.000 1.000 

08003751 8 Tomato-babyfood 0.900000 1.000 1.000 

08003760 8 Tomato, paste 0.900000 1.000 1.000 

08003761 8 Tomato, paste-babyfood 0.900000 1.000 1.000 

08003770 8 Tomato, puree 0.900000 1.000 1.000 

08003771 8 Tomato, puree-babyfood 0.900000 1.000 1.000 

08003780 8 Tomato, dried 0.900000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.900000 14.300 1.000 

08003790 8 Tomato, juice 0.900000 1.500 1.000 

09010750 9A Cantaloupe 0.100000 1.000 1.000 

09010800 9A Casaba 0.100000 1.000 1.000 

09011870 9A Honeydew melon 0.100000 1.000 1.000 

09013990 9A Watermelon 0.100000 1.000 1.000 

09014000 9A Watermelon, juice 0.100000 1.000 1.000 

09020210 9B Balsam pear 0.100000 1.000 1.000 

09020880 9B Chayote, fruit 0.100000 1.000 1.000 

09021020 9B Chinese waxgourd 0.100000 1.000 1.000 

09021350 9B Cucumber 0.100000 1.000 1.000 

09023080 9B Pumpkin 0.100000 1.000 1.000 

09023090 9B Pumpkin, seed 0.100000 1.000 1.000 

09023560 9B Squash, summer 0.100000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.100000 1.000 1.000 

09023570 9B Squash, winter 0.100000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.100000 1.000 1.000 

19010280 19A Basil, fresh leaves 30.000000 1.000 1.000 

19010281 19A Basil, fresh leaves-babyfood 30.000000 1.000 1.000 

19010290 19A Basil, dried leaves 144.000000 1.000 1.000 

19010291 19A Basil, dried leaves-babyfood 144.000000 1.000 1.000 

86010000 O Water, direct, all sources 0.136200 1.000 1.000 

86020000 O Water, indirect, all sources 0.136200 1.000 1.000 

95001750 O Grape 1.500000 1.000 1.000 

95001760 O Grape, juice 1.500000 1.000 1.000 

95001761 O Grape, juice-babyfood 1.500000 1.000 1.000 

95001770 O Grape, leaves 1.500000 1.000 1.000 

95001780 O Grape, raisin 1.500000 1.000 1.000 

95001790 O Grape, wine and sherry 1.500000 1.000 1.000 

95001880 O Hop 10.000000 1.000 1.000 

95003800 O Tomato, Tree 0.900000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 12 of 15

Attachment 2. Acute Results File.

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for CYAZOFAMID (1994-98 data)

Residue file: acute cyazofamid food+water 043012.R98

 Adjustment factor #2 used.

Analysis Date: 04-30-2012/13:37:42 Residue file dated: 04-30-2012/13:35:46/8

NOEL (Acute) = 100.000000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

Run Comment: "Drinking water using turf & ornamentals inc. parent, CCIM, CCIMAM"

===============================================================================

Summary calculations (per capita):

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Females 13-49 yrs:

 0.024799 2.48 4032 0.041882 4.19 2387 0.068117 6.81 1468 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 13 of 15

Attachment 3. Chronic Food Residue Input File.

Filename: C:\Documents and Settings\NDODD\My Documents\Deemfcidndodd\Cyazofamd\chronic 

cyazofamid food+water 041912.R98

Chemical: cyazofamid

RfD(Chronic): .95 mg/kg bw/day NOEL(Chronic): 94.8 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day

Date created/last modified: 04-19-2012/14:21:55/8 Program ver. 2.03

Comment: Drinking water using turf and ornamentals inc. only CTCA 

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

01010780 1AB Carrot 0.090000 1.000 1.000 

01010781 1AB Carrot-babyfood 0.090000 1.000 1.000 

01010790 1AB Carrot, juice 0.090000 1.000 1.000 

01030150 1CD Arrowroot, flour 0.020000 1.000 1.000 

01030151 1CD Arrowroot, flour-babyfood 0.020000 1.000 1.000 

01030170 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 

01030820 1CD Cassava 0.020000 1.000 1.000 

01030821 1CD Cassava-babyfood 0.020000 1.000 1.000 

01031390 1CD Dasheen, corm 0.020000 1.000 1.000 

01031660 1CD Ginger 0.020000 1.000 1.000 

01031661 1CD Ginger-babyfood 0.020000 1.000 1.000 

01031670 1CD Ginger, dried 0.020000 1.000 1.000 

01032960 1C Potato, chips 0.020000 1.000 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.020000 1.000 1.000 

01032980 1C Potato, flour 0.020000 1.000 1.000 

01032981 1C Potato, flour-babyfood 0.020000 1.000 1.000 

01032990 1C Potato, tuber, w/peel 0.020000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 

01033660 1CD Sweet potato 0.020000 1.000 1.000 

01033661 1CD Sweet potato-babyfood 0.020000 1.000 1.000 

01033710 1CD Tanier, corm 0.020000 1.000 1.000 

01033870 1CD Turmeric 0.020000 1.000 1.000 

01034060 1CD Yam, true 0.020000 1.000 1.000 

01034070 1CD Yam bean 0.020000 1.000 1.000 

04010050 4A Amaranth, leafy 10.000000 1.000 1.000 

04010180 4A Arugula 10.000000 1.000 1.000 

04011040 4A Chrysanthemum, garland 10.000000 1.000 1.000 

04011330 4A Cress, garden 10.000000 1.000 1.000 

04011340 4A Cress, upland 10.000000 1.000 1.000 

04011380 4A Dandelion, leaves 10.000000 1.000 1.000 

04011500 4A Endive 10.000000 1.000 1.000 

04012040 4A Lettuce, head 10.000000 1.000 1.000 

04012050 4A Lettuce, leaf 10.000000 1.000 1.000 

04012480 4A Parsley, leaves 10.000000 1.000 1.000 

04013130 4A Radicchio 10.000000 1.000 1.000 

04013550 4A Spinach 10.000000 1.000 1.000 

04013551 4A Spinach-babyfood 10.000000 1.000 1.000 

05010610 5A Broccoli 1.200000 1.000 1.000 

05010611 5A Broccoli-babyfood 1.200000 1.000 1.000 

05010620 5A Broccoli, Chinese 1.200000 1.000 1.000 

05010640 5A Brussels sprouts 1.200000 1.000 1.000 

05010690 5A Cabbage 1.200000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 

05010830 5A Cauliflower 1.200000 1.000 1.000 

05011960 5A Kohlrabi 1.200000 1.000 1.000 

05020630 5B Broccoli raab 12.000000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 

05021170 5B Collards 12.000000 1.000 1.000 

05021940 5B Kale 12.000000 1.000 1.000 

05022290 5B Mustard greens 12.000000 1.000 1.000 

05023180 5B Rape greens 12.000000 1.000 1.000 

05023890 5B Turnip, greens 12.000000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 14 of 15

06010430 6A Bean, snap, succulent 0.500000 1.000 1.000 

06010431 6A Bean, snap, succulent-babyfood 0.500000 1.000 1.000 

06020310 6B Bean, broad, succulent 0.080000 1.000 1.000 

06020330 6B Bean, cowpea, succulent 0.080000 1.000 1.000 

06020370 6B Bean, lima, succulent 0.080000 1.000 1.000 

08001480 8 Eggplant 0.900000 1.000 1.000 

08002340 8 Okra 0.900000 1.000 1.000 

08002700 8 Pepper, bell 0.900000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.900000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.900000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.900000 1.000 1.000 

08002720 8 Pepper, nonbell 0.900000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.900000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.900000 1.000 1.000 

08003740 8 Tomatillo 0.900000 1.000 1.000 

08003750 8 Tomato 0.900000 1.000 1.000 

08003751 8 Tomato-babyfood 0.900000 1.000 1.000 

08003760 8 Tomato, paste 0.900000 1.000 1.000 

08003761 8 Tomato, paste-babyfood 0.900000 1.000 1.000 

08003770 8 Tomato, puree 0.900000 1.000 1.000 

08003771 8 Tomato, puree-babyfood 0.900000 1.000 1.000 

08003780 8 Tomato, dried 0.900000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.900000 14.300 1.000 

08003790 8 Tomato, juice 0.900000 1.500 1.000 

09010750 9A Cantaloupe 0.100000 1.000 1.000 

09010800 9A Casaba 0.100000 1.000 1.000 

09011870 9A Honeydew melon 0.100000 1.000 1.000 

09013990 9A Watermelon 0.100000 1.000 1.000 

09014000 9A Watermelon, juice 0.100000 1.000 1.000 

09020210 9B Balsam pear 0.100000 1.000 1.000 

09020880 9B Chayote, fruit 0.100000 1.000 1.000 

09021020 9B Chinese waxgourd 0.100000 1.000 1.000 

09021350 9B Cucumber 0.100000 1.000 1.000 

09023080 9B Pumpkin 0.100000 1.000 1.000 

09023090 9B Pumpkin, seed 0.100000 1.000 1.000 

09023560 9B Squash, summer 0.100000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.100000 1.000 1.000 

09023570 9B Squash, winter 0.100000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.100000 1.000 1.000 

19010280 19A Basil, fresh leaves 30.000000 1.000 1.000 

19010281 19A Basil, fresh leaves-babyfood 30.000000 1.000 1.000 

19010290 19A Basil, dried leaves 144.000000 1.000 1.000 

19010291 19A Basil, dried leaves-babyfood 144.000000 1.000 1.000 

86010000 O Water, direct, all sources 0.133500 1.000 1.000 

86020000 O Water, indirect, all sources 0.133500 1.000 1.000 

95001750 O Grape 1.500000 1.000 1.000 

95001760 O Grape, juice 1.500000 1.000 1.000 

95001761 O Grape, juice-babyfood 1.500000 1.000 1.000 

95001770 O Grape, leaves 1.500000 1.000 1.000 

95001780 O Grape, raisin 1.500000 1.000 1.000 

95001790 O Grape, wine and sherry 1.500000 1.000 1.000 

95001880 O Hop 10.000000 1.000 1.000 

95003800 O Tomato, Tree 0.900000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 15 of 15

Attachment 4. Chronic Results File.

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for CYAZOFAMID (1994-98 data)

Residue file name: C:\Documents and Settings\NDODD\My 

Documents\Deemfcidndodd\Cyazofamd\chronic cyazofamid food+water 041912.R98

 Adjustment factor #2 NOT used.

Analysis Date 04-26-2012/16:09:22 Residue file dated: 04-19-2012/14:21:55/8

Reference dose (RfD, Chronic) = .95 mg/kg bw/day

COMMENT 1: Drinking water using turf and ornamentals inc. only CTCA

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.008157 0.9%

U.S. Population (spring season) 0.008177 0.9%

U.S. Population (summer season) 0.008382 0.9%

U.S. Population (autumn season) 0.008035 0.8%

U.S. Population (winter season) 0.008032 0.8%

Northeast region 0.008203 0.9%

Midwest region 0.008064 0.8%

Southern region 0.007651 0.8%

Western region 0.009020 0.9%

Hispanics 0.008152 0.9%

Non-hispanic whites 0.007995 0.8%

Non-hispanic blacks 0.008239 0.9%

Non-hisp/non-white/non-black 0.010614 1.1%

All infants (< 1 year) 0.012989 1.4%

Nursing infants 0.005056 0.5%

Non-nursing infants 0.016000 1.7%

Children 1-6 yrs 0.012576 1.3%

Children 7-12 yrs 0.007814 0.8%

Females 13-19 (not preg or nursing) 0.006145 0.6%

Females 20+ (not preg or nursing) 0.008154 0.9%

Females 13-50 yrs 0.007838 0.8%

Females 13+ (preg/not nursing) 0.006836 0.7%

Females 13+ (nursing) 0.009165 1.0%

Males 13-19 yrs 0.006349 0.7%

Males 20+ yrs 0.007385 0.8%

Seniors 55+ 0.007790 0.8%

Children 1-2 yrs 0.014334 1.5%

Children 3-5 yrs 0.012279 1.3%

Children 6-12 yrs 0.008139 0.9%

Youth 13-19 yrs 0.006274 0.7%

Adults 20-49 yrs 0.007733 0.8%

Adults 50+ yrs 0.007855 0.8%

Females 13-49 yrs 0.007725 0.8%

-------------------------------------------------------------------------------