## IUR Petiti on Review Repor t Dec ember

22, 2004
CASRNs and TS CA Inventory Chem ical Nam es: 56-81-5 1,2,3-propa netriol
Alter nate Chem ical Nam es Used in P etitions: g ly cer ol g ly cer in
P etitioner s and DocketNum bers: P&G Company OPPT-2003-0059 Dow Chemica l Company OPPT-2003-0059 Keller & H eckma

n OPPT-2004-0071 Note: Other c hemicals wereincluded in the Keller &Hec kman pe tition, and these othe r chem icals are addressed in other pe tition r evie w reports. Summ ary of Decision: The pe tition review g roup dete rmined that, at this time, EPA has a low curr ent intere st in the processingand use infor mation collected unde r the I nventory Update Rule (IUR, 40 CFR Part 710) for 1,2,3-propa

netriol (CASRN 56-81-5) a nd there fore is recommending a grant for

this petiti on. This rec ommendation is based primar ily on Considerations B a

nd C. EPA will ini tiate rulemaking to a dd 1,2,3-propa netriol (CASRN 56-81-5) to the pa rtial exemption l ist at 40 CFR 710.46(b)(2) (iv). The final listing dec ision is pending, base d on response s to the FR notice. EPA may ree valuate the IUR repor ting status of 1,2,3- propane triol (CASRN 56-81-5) if the Ag ency obtains new infor

mation indicating a

need f or proc essingand use information. Please note that IUR submitt ers c an still report proc essingand use infor mation even if a

chemica l is partially

exempt, so t hat their c hemicals c an be c onsidered f or saf er substitute ana ly ses. Background : EPA rec eived a petition requestingthat 1,2,3-propa netriol (CASRN 56-81-5) be exempted from re portingproce ssing a nd use information under the Inventory Update Reporting rule (I UR) ( See40 CFR 710.46(b)( 2)(iv)) . The c hemical substanc es included on this “pa rtial exemption” lis t are substances f or which EPA ha s previously deter mined that there is a low curr ent intere st in the IUR proce ssing a nd use information. However , as stated in the pr eamble to the amendment to the I UR promulgated on J anuar y 7, 2003 (68 F R 854), “...the ne ed for proce ssing a

nd use information ... chang es over time. The inclusion of a c hemical substanc e under this par

tial exempti on is not based on the potential risks of a chemica l. This partial exemption i s solely

intended to provide a

tool to assistthe Ag ency in better mana g ing the collection of pr ocessingand use infor mation...” and is also “ba sed on the Ag ency ’s cur rent ne ed for c ollectingIURA proce ssing a nd use information.” (68 F R 855) Additionally , the pre amble states “In deter

mining whe ther ther e is low curr ent intere st in IURA proce ssing a nd use
Pag e 1 of 6

## information re lated to a spe cific c hemical substanc e, EPA will look to the specific c ircumstance s

surroundingthe che mical in question, and may use one or

more of the considerations identified below, and/or

considerations not i dentified be low, to make an inf ormed de cision.” The considerations used by

EPA in reviewingthis petiti on and an a naly sis of how those considerations relate to the c hemicals identified in this petition are se t forth below.
Discussion : The pe tition review g roup consider ed information submi tted with the petition, as well as other

information including(but not limi ted to): whethe r the pe tition s ubstance s are included in TRI , I RI S, or IARC; OECD SI DS prog ram status; and HPV Challeng e Program status and other r egulatory programs administere d by EPA. 1 

## The pe tition from Proctor and Ga mble (docke t number OPPT-2003-0059) linked infor mation provided in the pe tition t o specific considerations cited in 40 CFR 710.46(b)(2) (ii), providinga citation to a SIAR and other inf ormation. Whil e ther e we re two othe r petitions submit ted, EPA relied upon the information submitted by Proctor and G amble for

this review. Consideration A: Production volume

. The pe tition review g roup found that ther e wa s at least one site r eportingin 2002 with a production volume for

1,2,3-propa

netriol (CASRN 56-81-5) of 300,000 pounds or g reater. Consideration B: The substance’s che mical and physical properties or potential for persistence, bioaccumulation, health effec ts, or environmental effec ts. The pe tition i ncluded the SIAR (dated 01/02/2002) f or 1,2,3-pr opanetr iol (CASR N 56-81-5) , and provided a

summary of spec ific, per

tinent details. The SIAR conclude d that there is a low hazard potential for 1,2,3- propane triol (CASRN 56-81-5) (Ref 1). Ac cording

to the SI AP, dated Mar ch 2002, the “we ight of

evidenc e indicate s that 1,2,3-propa netriol (CASRN 56-81-5) is of low tox icity when ing ested, inhale d, or in contac t with the skin” (Ref 2) . The pe tition s ummary of the SI AR stated that 1,2,3-propa netriol (CASRN 56-81-5) ha s low hazard to the aquatic environment. Additionally , the petition noted that “the SIAR conclude d that based on the available data, g ly cer ol: 1. I s considere d to be re adily biodeg rada

ble in the aquatic environment. (Sec tion 2.1.5, p.5) 2. I s not ex pecte d to bioaccumulate . (Section 2.1.6, p.5) 3. I s approve d for use as a dire ct food a dditive, indirect food a dditive and is rec ognized as g ener ally safe for use in food. (Section 2.2, p.6) 4. I s of ver

y low acute tox icity

to mammals. (Section 3.1.2.2, p. 8) 5. Has no in vitro or in vivo data indicating a g enotoxi c potential. (Sec tion 3.1.4, p. 12)

S e e t h e a t t a c h e d l i s t o f a c r o n y m s a t t h e e n d o f t h i s r e p o r t

. 1 

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## 6. Does not ra ise conc ern f or ca rcinog enic potential. ( Section 3.1.5, p.12) 7. Does not have any

adver se ef

fec ts on reproduc tive para meters. ( Section 3.1.6 p.13) 8. I s not irritating when in contac t with the skin. (Section 3.1.7.1, p.13) 9. I s not irritating to the e y es. (se ction 3.1.7.2, p.14) 10. Has no human or

animal data indicating it is a skin sensitiz er. ( Section 3.1.7.3, p. 14) 11. I s of low ac ute tox icity to fish and aquatic invertebr ates. (Sec tion 4.1.l, p. 15) 12. I s of low ac ute or c hronic toxi city to alg ae. ( Section 4.1.2, p. 16) 13. I s of low tox icity

to bacter ia. (Sec tion 4.1.3, p.17) 14. I s of low hazard to the a quatic envir onment. (Section 4.1.5, p. 17)” EPA has re viewed this information and conclude s at this tim e that ther e is no evidenc e of conce rns about per sistence, bioac cumulation, human hea lth effe cts or envir onmental ef fec ts. Consideration C : The information needs of EPA, other fede ral agencies, tribes, states, and local governm ents, as well as members of the public. 1,2,3-Propane triol (CASRN 56-81-5) wa s orig inally excluded by

EPA from the Ag ency ’s HPV Challeng e program ba sed on a pr eliminary EPA review

indicatingthat testing usingthe SI DS base se t would not further our understandingof the c hemical' s proper ties, but was voluntarily sponsored by

the I CCA APAG Gly cer ol Group and the ref ore is par t of the HPV Challeng e prog ram. B eca

use it was sponsore d, EPA did not li st this chemical on the initial listof par tially exempt subst ance s at 40 CFR 710.46(b)( 2)(iv) ( see Methodology U sed for the Initial Selection of Chemicals for the Inve ntory Update Rule A mendme nts ( IURA) ‘Low Curr ent Intere st’ Partial Reporting Exe mption for a dditional information). Howe ver, EPA c ontinues to believe that more information on 1,2,3-propa netriol (CASRN 56-81-5) w ould not further our understandingof this chemica l. As demonstrated in c onsideration B , there is no evidence of conc erns a bout persistenc e, bioac cumulation, human hea lth effe cts, or envir onmental ef fec ts, and there fore the IUR proce ssing a

nd use informa

tion is of low curre nt interest. As of the wr iting of this re port, other c urre nt needs for IUR proce ssing a

nd use information for 1,2,3-propa

netriol (CASRN 56-81-5) w ere not identified. This petition was circ ulated amongthe Intera g ency

TestingCommi ttee member s; no one identified a c urre nt interest in the IUR proce ssing a

nd use information for this chemica l. The proc ess for a dding this che mical to the partial e x emption listinvolves publishing a F eder al Reg ister notice a sking f or comment, including a sking if the re is intere st in the IUR proce ssing a nd use information for this chemica l. Consideration D: The availabilit y of other com

plementary

risk scree ning informati on. The pe tition not ed that the c ompleted SI AR contains risk scre eninginformation, which se rves a s a sourc e of c omplementary risk scre eninginformation. The pe tition also l isted other sourc es of additional risk scre eninginformation, and that the c onclusions of those other sour ces a g ree d with the conc lusion in t he SIAR. As noted in consideration B, EPA believe s that, due to the

Pag e 3 of 6

## extremely

low hazard of this che mical, additional risk scre eninginformation is not neede d at this time. Consideration E: The availabili ty of comparable proc essing and use information. The pe tition not ed that ther e we re se vera l sources of proce ssing a

nd use data

and stated that data from those sourc es ar e compa rable to the IUR proce ssing a nd use data . EPA has re viewed those source s and disagree s that the data a re c ompara

ble. In light of the extremely low hazard of this chemica l, however , the petition review g roup believe s the IUR proce ssing a nd use information for 1,2,3- propane triol (CASRN 56-81-5) is of low cur rent intere st at this ti me. EPA may ree valuate the IUR repor

ting status of this che mical in the future if the Ag ency obtains new information indicatinga nee d for pr ocessingand use infor mation. Consideration F: W

hether the pote ntial risks for the che mical substance areadequately m anaged by EPA or another age ncy or authority. The pe tition s tates that 1,2,3-pr opanetr iol (CASR N 56-81-5) use and ma

nufac turingwould primarily fall under

the authority

of EPA, FD A, OSHA, and CPSC. The petition did notprovide specific information on this point, and theref ore EPA c ould not evaluate this consider ation. Howeve r, in light of the considerations discussed above, the w orkgroup believe s the IUR proce ssing a

nd use information is of low curre nt interest. Other Considerations: Additionally , the petitioner notes that 1,2,3- propane triol (CASRN 56-81-5) is a compone nt part of all natura l triglycer ides and re lated mono/diglycer ides, such as the animal fats and veg etable oils that are a lso curre ntly listed on the partial exemption. This rationale is not compelling - a “natur al” c hemical is not nec essar ily a saf e che mical and ther efor e any “natur al” a spect is not g erma ne to the dete rmination of intere st.

CitedRefere nc es: 1. Screening In f

orma tion Data Set (SIDS) Initi al A ssess m ent Repo rt (SIAR) f or S IA M 1 4, January

2, 20 02 , EP A

Docket # OP P T-2003 -00 59 -00 03

. 2. Screening In f

orma tion Data Set (SIDS) Initi al A ssess m ent P rofile (SIAP ), M arch 20 02 , available at http ://cs3-h q.o ecd.org/scripts/h pv/Statu s/DownloadFi le.A SP ?CA SNUM=56 81 5&Statu sCode=SIARC& DataNo=1
Sou rce s Searc he d: ( Note: T hese sources are typi cally searched or reviewed to ga ther in format ion presented in the p etition review re po rt).
Am erican Con f

erence of G overnm ental In du strial Hy gienists (A CG IH) ThresholdLimit V alues (TLV -TW A ). 2 00 3. A CG IH, Cincin nati OH. pp . 1 2-6 1.
A gency for Toxic Su bstances andDisease Registry (A TSDR) T oxFA Qs (Frequ ently aske d q uestion s abou t con tam inan ts found T M at hazardou s w aste sites). Available at http ://ww w .atsdr.cd c.gov/toxf

aq.h tm l


## Pag e 4 of 6Calif orn ia A ir Resou rces Board List of T oxic A ir Co ntam inan t Fact Sh eets, av ailable at http ://arbis. arb.ca.gov/toxics/tac/toctbl. htm Calif orn ia EP A , Safe Drinking W ater and Toxic Enforcem ent Ac t o f 19 86 : List of chemicals known t o t he St ate to cause cancer or rep rod uctive toxicity . Listing as of Nov. 1 4, 20 03 . Av ailable at http ://ww w .oeh ha.ca.gov/prop 65 /CRNR_n otices/list_ changes/111 40 3lsta.h tm l
Intern ation al A gency

of Resea rch o n Can cer (IARC) Overa ll Evaluatio ns o f Carcinogenicity

to Huma ns. A vailable at http ://m on ographs.i arc.f

r/m on oeval/crthall.ht ml Interagency

Te sting Co m

m ittee (ITC) P riori ty

Te sting List. Av ailable at h ttp: //tsca-itc.sy rres.com /Chem icals/ Nation al A dvisory

Committee A cute Expo sure Guid eline Lev els (A EG Ls ). Av ailable at h ttp: //ww w .epa.gov/op pt/aegl/ind ex.htm Orga nisatio n for Eco no m ic Coo peration andDeve lop m ent (OECD) In tegra ted HP V Database, http ://cs3-h q.o ecd.org/scripts/h pv/ind ex.a sp UnitedNation s Enviro nm ent P rogram m e (UNEP ) persistent organic po llut ants (P OP s), available at http ://ww w .chem .un ep.ch/p op s/defa ult. html

UnitedNation s Enviro nm ent P rogram m e (UNEP ) Ozone S ecre tariat, Su m m ary Con trol Measures, ava ilable at http ://ww w .un ep.o rg/ozon e/T reaties_and_ Ratif ication/2B_ m on treal_pro toco l.asp
U.S. EP A Clean Air A ct (CAA ) Hazardous Air P ollu tants (HAPs). Available in t he Clean Air A ct, section 11 2(b ), available at http ://ww w .epa.gov/air/caa/c aa112 .txt U.S. EP A . E m erge ncy

P lann ing andComm

un ity Right-to -Kno w

A ct Section 31 3, Lis t o f

Toxic Chemicals. 20 01 . Off ice of Enviro nm ental In f

orma tion , EP A 26 0-B-0 1-0 01 , available at http:// w w w .epa.gov/tri/chem ical/chem list20 01 .pd f
U.S. EP A HP V (High P rod uctio n V olu m e) Challenge P rogram andV olu ntary

Chi ldren 's Chem ical Evaluation P rogram (V CCEP ) Web sites und er the EP A Chem ical Right-to -Kno w Ini tiative, h ttp: //ww

w .epa.gov/chem

rtk
U.S. EP A Int egra ted Risk Inform ation Sy stem (IRIS) Sub stance L ist. Available at http ://ww w .epa.gov/iris/sub st/ind ex.htm l
U.S. EP A . Natio nal Recomm endedWater Quality Criteria: 2 00 2. Of

f ice of W ater. EP A -82 2-R-0 2-0 47 . Av ailable at http ://ww w .epa.gov/w atersc ience/pc/revcom .pd f
U.S. EP A . 2 00 4 E diti on of the Drin king W ater Stand ards andHealth Advisories. Off ice of W ater. EP A -82 2-R-0 4-0 05

. Available at http ://ww

w .epa.gov/w atersc ience/drin king/standards/d w standard s.pd f
U.S. EP A Su bstance Registry

Sy stem (SRS ). Av ailable at h ttp: //ww w .epa.gov/srs/
U.S. Occupation al Saf

ety andHealth Adm inistratio n (OS HA ) P erm issible Expo sure Limits (P ELs), av ailable at http ://ww w .osh a.gov/SL TC /pel/in dex.html



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## List of A crony ms ACGIH Am eric an Conf erence of Governm ental Indus trial Hygienis ts A EG L Ac ute Exposure G uideline Level A RB Ai r Res ources B oard A TSDR Agenc y for Tox ic S ubst ances and Dis ease Regis try CA A Clean A ir A ct CA SRN Chem ic al A bst ract S ervice Regis try Num ber CICA D Conci se Int ernational Chem ic al A ss ess m ent Docum ent CPS C Consum er P roduct S afet y Com m is si on EHC Environm ental Health Criteria EP A Environm ental Prot ect ion A gency EU European Union FDA Food and Drug Adm inis trat ion FFDCA Federal Food, Drug, and Cosm etic A ct FI FRA Federal Ins ect ic ide, Fungic ide, and Rodent ic ide A ct GRA S Generally Recogn ized as S afe HA P Hazardous Ai r P ollut ant HPV High P roduct ion V olum e HSDB Hazardous Subs tanc es Databank IA RC Int ernational A gency of Researc h on Cancer ICCA Int ernational Counc il of Chem ic al A ss oci ations IF CS Int ernational F orum on Chem ic al S afet y IP CS Int ernational P rogram m e on Chem ic al S afet y IRI S Int egrated Ris k Inform ation Sys tem IRP TC Int ernational Regis ter of Pot ential ly T ox ic Chem ic als ITC Int eragency Tes ting Com m itt ee IUCL ID Int ernational Unif orm Chem ic al I nform ation Databas e IUR Invent ory Update Reporting Rule IURA Invent ory Update Reporting Rule A m endm ent NA ICS North Am eric an I ndust ry Clas si fic ation Sys tem NIOS H Nationa l I nst itut e f or Oc cupat ional Saf ety an d Healt h OE CD Organis ation for Ec onom ic Cooperat ion an d Developm ent OE CD HP V SI DS or OE CD HP V SI DS pro gram OE CD/S IDS HP V Chem ic als P rogram m e
OP P Off ic e of P est ic ide P rogram s OP PT Off ic e of P ollut ion P revention and T ox ic s OS HA Oc cupat ional Saf ety an d Healt h A dm inis trat ion PE L Perm is si ble E x posure Lim it PO P Pers is tent Organi c Pol lutant SI A M SI DS Init ial As ses sm ent Meeting SI A P SI DS Init ial As ses sm ent Prof ile SI A R SI DS Init ial As ses sm ent Report SI DS Sc reening I nform ation Data Set SRS Subs tanc e Regis try S yst em TLV-TW A Thres hold L im it Val ue T im e-W eighte d A verage TRI Tox ic s Releas e I nventory TSCA Tox ic S ubst ances Cont rol A ct UNEP United Nations E nvironm ent Program m e VCCE P Vol untary Chi ldren’s Chem ic al E valuatio n P rogram



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