<PAGE>

                                                          Confidential Treatment
                                                          EXHIBIT 10.24

THE REGISTRANT HAS REQUESTED CONFIDENTIAL TREATMENT FOR CERTAIN PORTIONS OF THIS
AGREEMENT. THOSE PORTIONS HAVE BEEN OMITTED FROM THIS COPY OF THE AGREEMENT AT 
THE PLACES INDICATED BY "XXXXXXXXXX"; AND HAVE BEEN FILED SEPARATELY WITH THE 
SECURITIES AND EXCHANGE COMMISSION.


                 AMENDMENT TO SALES AND DISTRIBUTION AGREEMENT
                 ---------------------------------------------

     AMENDMENT TO SALES AND DISTRIBUTION AGREEMENT ("Amendment") made as of June
26, 1996, by and among CENTOCOR, INC. a Pennsylvania corporation ("CNTO"),
CENTOCOR B.V., a Netherlands corporation ("CBV"); and together with CNTO,
collectively, ("Centocor"), and ELI LILLY AND COMPANY, an Indiana corporation
("Lilly").

                                   BACKGROUND
                                   ----------

     A.   Centocor and Lilly are parties to a certain Sales and Distribution
Agreement dated July 15, 1992, as amended (the "Agreement").

     B.   Centocor and Lilly now desire to amend certain provisions of the
Agreement as set forth herein.

     C.   Capitalized terms used but not defined herein shall have the meanings
given to them in the Agreement.

     NOW, THEREFORE, Centocor and Lilly, each intending to be legally bound
hereby, agree as follows:

     1.   Amendments. The Agreement shall be amended as follows:
          ----------                                            

          1.1  ReoPro.  All references in the Agreement to "CentoRx" shall be 
               ------   
deemed to refer to "ReoPro", and Section 1.6 of the Agreement shall be amended
and restated in its entirety to read as follows:

               "l.6   "ReoPro" means the 7E3(TM) monoclonal antibody
                      pharmaceutical product known as ReoPro(R) in the
                      Territory."

          1.2  Territory.  Notwithstanding any provision of the Agreement to
               ---------                                                    
the contrary, including, without limitation, Section 13.4 of the Agreement, the
term "Territory" as it applies to ReoPro shall mean "the entire world, except
for Japan".

     2.   Continuing Research, Development and Commercialization of ReoPro.
          ---------------------------------------------------------------- 
Notwithstanding anything in the Agreement, or any correspondence or discussions
entered into in connection therewith, Centocor and Lilly hereby agree that all
costs and expenses as described in Article VII and Exhibit A of the Agreement
incurred after the date of this Amendment in connection with the continued
research, development and commercialization of ReoPro in the Territory,
including, but not limited to, costs and expenses of clinical studies for
xxxxxxxxxx shall be shared xxxxxxxxxxx by Centocor and Lilly in accordance with
the xxxxxxxxxx sharing system described 
<PAGE>
 
in Article VII and Exhibit A of the Agreement. Notwithstanding the foregoing,
all cost sharing as described in this Amendment and the Agreement shall be
limited to those costs related to plans approved by the Product Committee.

     3.   Clinical Development of ReoPro.  Centocor and Lilly each hereby agree
          ------------------------------                                       
to proceed with the clinical development of ReoPro for xxxxxxxxxxx.

     4.   Closing Date; Settlement Date.  The closing of the transactions
          -----------------------------                                  
contemplated by this Amendment is to be held on June 26, 1996 (the "Closing
Date").  The transactions contemplated by this Amendment including, but not
limited to, the amendments set forth in Section 1 hereof shall only become
effective on the Closing Date provided that all the conditions set forth in
Section 10 hereof are fully satisfied or waived as described in Section 10 of
this Amendment.  On July 9, 1996 (the "Settlement Date") CNTO shall deliver to
Lilly a certificate or certificates representing the Shares to be issued to
Lilly pursuant to the provisions of Section 5 of this Amendment.

     5.   Consideration.
          ------------- 

          5.1  Consideration for Amendment.  In consideration of Lilly's 
               ---------------------------   
agreement to amend the Agreement to exclude Japan from the Territory as provided
in Section 1.2 hereof and Lilly's agreement as set forth in Section 13 hereof,
on the Settlement Date, CNTO shall issue to Lilly such number of shares
("Amendment Shares") of CNTO's common stock, par value $ .01 per share ("Common
Stock"), as determined by dividing xxxxxxxxxxx by the average of the last
reported sale price per share of CNTO Common Stock on the NASDAQ National Market
for the five (5) Trading Days (hereinafter defined as in Section 5.3 hereof)
immediately preceding the Settlement Date (the "Average Price").

          5.2  Other Consideration.  In consideration of xxxxxxxxxx
               -------------------                      
which the parties acknowledge will strengthen scientific and marketing support
for ReoPro, and in consideration of Lilly's agreements with respect to the
development xxxxxxxxxxx as described in Section 2 and 3 above, on the
Settlement Date, CNTO shall issue to Lilly such number of shares ("Other
Shares"; and together with the Amendment Shares, the "Shares") of CNTO's Common
Stock, as determined by dividing xxxxxxxxxxx by the Average Price.

          5.3  Post-Closing Adjustment.
               ----------------------- 

               (a)  If the Registration Statement (as defined in Section 7.1
hereof) is declared effective by the Securities and Exchange Commission ("SEC")
within the five (5) Trading Days (as hereinafter defined) immediately following
the Settlement Date, no post-closing adjustment shall be made to the
consideration set forth in Section 5.1 and 5.2 hereof. For the purposes of this
Amendment, a "Trading Day" shall mean a day on which the NASDAQ National Market
is open

                                      -2-
<PAGE>
 
for business. The date on which the Registration Statement is declared effective
is referred to herein as the "Registration Date".

               (b)  If the Registration Statement is not declared effective by
the SEC within the five (5) Trading Days immediately following the Settlement
Date, a post-closing adjustment shall be calculated as follows:

                    (i)    if the product of X, the average of the last reported
sale price per share of CNTO Common Stock on the NASDAQ National Market for the
five Trading Days immediately preceding the Registration Date (the "Registration
Date Closing Price"), multiplied by Y, the total number of Shares or Shortfall
Shares, whichever may be the case, issued to Lilly under this Amendment, is less
than xxxxxxxxxx then CNTO shall pay the difference (the "Shortfall Amount") to
Lilly within five (5) business days following the Registration Date. CNTO shall
have the option of paying the Shortfall Amount in cash or in shares of CNTO
Common Stock; or

                    (ii)   if the product of X, the Registration Date Closing
Price, multiplied by Y, the total number of Shares issued to Lilly under this
Agreement, is greater than xxxxxxxxxx then Lilly shall pay the difference (the
"Excess Amount"). Lilly shall pay the Excess Amount to CNTO within five (5)
business days following the Registration Date. Lilly shall have the option of
paying the Excess Amount in cash or in shares of CNTO Common Stock.

               (c)  If CNTO is obligated to pay the Shortfall Amount and elects
to make such payment in shares of CNTO Common Stock: (i) the number of shares
(the "Shortfall Shares") of CNTO Common Stock to be delivered to Lilly shall be
determined by dividing the Shortfall Amount by the Registration Date Closing
Price; and (ii) the provisions of this Section 5.3 and Sections 5.4, 6, 7 and
11 of this Amendment shall apply to the Shortfall Shares as if they were
"Shares" as such term is used in those Sections; provided, however, that with
respect to the Shortfall Shares, references to the Settlement Date shall mean
the date the Shortfall Shares are delivered by CNTO to Lilly and references to
the xxxxxxxxxx shall mean the Shortfall Amount.

               (d)  If Lilly is obligated to pay the Excess Amount and elects to
make such payment in shares of CNTO Common Stock the number of shares of CNTO
Common Stock to be delivered to CNTO shall be determined by dividing the Excess
Amount by the Registration Date Closing Price.

          5.4  Late Fee Penalty.  In the event that the Registration Date does 
               ----------------   
not occur within five (5) Trading Days immediately following the Settlement
Date, a daily late fee penalty shall be imposed on CNTO for each day after the
Settlement Date through the day immediately prior to the Registration Date (the
"Late Fee"). The daily Late Fee imposed shall be equal to the United States
three-month Treasury Bill interest rate, divided by 365 days, as quoted in the
Wall Street Journal as of the Settlement Date, multiplied by xxxxxxxxxx The Late
Fees shall be due and payable to Lilly thirty (30) days after the Settlement
Date and to the extent applicable every thirty (30) days thereafter.

                                      -3-
<PAGE>
 
     6.   Restriction of Transferability
          ------------------------------

          6.1  Transfers Generally.  The Shares shall be transferable only upon
               -------------------   
the conditions specified in this Section 6, which conditions are intended to
insure compliance with the provisions of the Securities Act of 1933, as amended,
and the Regulations promulgated thereunder or with respect thereto, or any
successor or substitute laws (the "1933 Act").

          6.2  Transfers of Shares Pursuant to Registration Statements and Rule
               ----------------------------------------------------------------
144.  The Shares may be offered or sold by Lilly pursuant to (a) an effective
---
registration statement under the 1933 Act, or (b) to the extent applicable, Rule
144 ("Rule 144") as promulgated by the Securities and Exchange Commission
("SEC") under the 1933 Act.

          6.3  Other Transfers.  Lilly may transfer any or all of the Shares, 
               ---------------   
without registration or without compliance with the provisions of Rule 144, so
long as it so notifies CNTO and such notification is accompanied by an opinion
of counsel reasonably acceptable to CNTO to the effect that such transfer may be
made without registration under the 1933 Act of the Shares sought to be
transferred.

          6.4  Restrictive Legends.  Until otherwise permitted by Section 6.5
               -------------------                                           
hereof, each certificate representing any of the Shares shall bear a legend in
substantially the following form:

          THE SALE, DISPOSITION OR OTHER TRANSFER OF THE SECURITIES REPRESENTED
     BY THIS CERTIFICATE IS SUBJECT TO CERTAIN RESTRICTIONS ON TRANSFERS
     SPECIFIED IN THAT CERTAIN AMENDMENT TO SALES AND DISTRIBUTION AGREEMENT
     DATED AS OF JUNE 26, 1996, BETWEEN CENTOCOR, INC., CENTOCOR B.V. AND ELI
     LILLY AND COMPANY, AS THE SAME MAY BE AMENDED OR SUPPLEMENTED FROM TIME TO
     TIME, AND NO TRANSFER OF THE SECURITIES REPRESENTED BY THIS CERTIFICATE
     SHALL BE VALID OR EFFECTIVE UNTIL THE CONDITIONS TO ANY TRANSFER WHICH ARE
     SET FORTH IN SUCH AGREEMENT HAVE BEEN SATISFIED. A COPY OF THE FORM OF SUCH
     AGREEMENT IS ON FILE AT THE OFFICE OF THE SECRETARY OF CENTOCOR, INC. AND
     MAY BE INSPECTED DURING NORMAL BUSINESS HOURS.

          THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
     REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, NOR HAVE ANY OF
     THEM BEEN REGISTERED OR QUALIFIED UNDER THE SECURITIES OR BLUE SKY LAWS OF
     ANY STATE. THE SECURITIES REPRESENTED BY THIS CERTIFICATE MAY NOT BE SOLD,
     ASSIGNED, PLEDGED, HYPOTHECATED, ENCUMBERED OR IN ANY OTHER MANNER
     TRANSFERRED OR DISPOSED OF, EXCEPT IN COMPLIANCE WITH THE SECURITIES ACT OF
     1933, AS AMENDED, THE RULES AND REGULATIONS

                                      -4-
<PAGE>
 
     PROMULGATED THEREUNDER, AND APPLICABLE STATE SECURITIES OR BLUE SKY LAWS
     AND REGULATIONS.

          6.5  Termination of Restrictions.  All restrictions imposed on the 
               ---------------------------   
Shares pursuant to this Section 6 shall cease and terminate automatically as to
any particular Shares when such Shares (a) shall have been effectively
registered under the 1933 Act (whether pursuant to the provisions of Section 7
hereof, or otherwise) and applicable state securities or blue sky laws, (b)
shall have been sold under and pursuant to Rule 144, or (c) shall be eligible to
be sold under and pursuant to subsection (k) of Rule 144.

     7.   S-3 Registration Rights.
          ----------------------- 

          7.1  Registration Rights.  CNTO will, at its sole expense, within 
               -------------------   
five (5) days following the Settlement Date, file a registration statement (the
"Registration Statement") with respect to the Shares on Form S-3 under the 1933
Act in a manner that will, upon being declared effective, constitute a "shelf"
registration for purposes of Rule 415 under the 1933 Act, pursuant to which
Lilly may sell the Shares, from time to time and in such amounts as Lilly may
hereafter determine in its discretion, all in a manner consistent with the
applicable provisions of the 1933 Act, and the Exchange Act of 1934, as amended,
and the Regulations promulgated thereunder or with respect thereto, or any
successor or substitute laws (the "1934 Act"). CNTO will, at its sole expense,
promptly register or qualify the Shares under such other securities or blue sky
laws of such jurisdictions within the United States as Lilly may reasonably
request and do any and all other acts and things which may be necessary or
desirable to enable Lilly to consummate the public sale or other disposition in
such jurisdictions of the Shares.

          7.2  Other Filings.  With respect to registration under Section 7.1, 
               -------------   
until the second anniversary of the Settlement Date, CNTO shall prepare and file
such amendments, post effective amendments and periodic reports under the 1934
Act as may be necessary (a) to keep the Registration Statement continuously
effective, and (b) to ensure that the Registration Statement, including all
documents incorporated into the Registration Statement, does not contain any
untrue statement of a material fact or omission of a material fact necessary to
make the statements made therein not misleading. Notwithstanding the foregoing,
CNTO shall not be required to update, pursuant to this Section 7.2, any document
during a period when CNTO shall, in good faith and using reasonable business
judgment, believe that the premature disclosure of any event or information
would have a material adverse effect on, or not to be in the best interests of
CNTO and that such disclosure is not then required under the 1934 Act. In such
case, CNTO shall notify Lilly immediately that it has reached such a judgment,
without disclosing to Lilly the underlying event or information. Lilly hereby
agrees, that upon receipt of such notice from CNTO, Lilly shall forthwith
discontinue any disposition of the Shares until Lilly's receipt of the copies of
the supplemented or amended prospectus, and, if so directed by CNTO, Lilly shall
deliver to CNTO all copies in its possession, other than permanent file copies
then in Lilly's possession, of the prospectus covering such Shares current at
the time of receipt

                                      -5-
<PAGE>
 
of such notice. Notwithstanding anything to the contrary in this Amendment, CNTO
shall use its commercially reasonable efforts to provide Lilly with copies of
the supplemented or amended prospectus or any other related updated document
pertaining to such event or information described in this Section 7.2 as soon as
reasonably practicable and in any event not later than thirty (30) days after
Lilly receives notice from CNTO as described in this Section 7.2.

          7.3  Further Actions by Lilly.  Lilly agrees to furnish to CNTO, in
               ------------------------                                      
writing, such information with respect to itself and the proposed distribution
by it, and to execute such documents regarding the Shares received by it
hereunder, and the intended method of disposition thereof as CNTO shall
reasonably request and as shall be required in connection with the actions to be
taken by CNTO under the provisions of this Section 7.

     8.  Representations and Warranties of Centocor.  CNTO and CBV each
         ------------------------------------------                    
represent and warrant as follows:

          8.1  Organization and Good Standing.  Each of CNTO and CBV is a 
               ------------------------------   
corporation duly organized, validly existing and in good standing under the laws
of its jurisdiction of incorporation, is duly qualified to do business as a
foreign corporation and is in good standing in each jurisdiction in which the
nature of its business or the ownership of its property makes such qualification
necessary, except where the failure to so qualify or be in good standing would
not have a Material Adverse Effect (as defined in Section 8.8), and is
authorized to own or lease its properties and to carry on its business as it is
now being conducted. The copies of CNTO's Articles of Incorporation, as amended
and restated, and Bylaws, in the forms attached hereto as Exhibit A, are
complete and correct.

          8.2  Corporate Power and Authority; Enforceability.  CNTO and CBV each
               ---------------------------------------------                    
have the requisite power and authority (corporate and otherwise) to execute,
deliver and perform this Amendment and to consummate the transactions
contemplated hereby.  The execution, delivery and performance by CNTO and CBV of
this Amendment and the consummation by CNTO and CBV of the transactions
contemplated hereby, have been duly authorized by all necessary action
(corporate or otherwise) on its part.  This Amendment constitutes a legal, valid
and binding obligation of CNTO and CBV, enforceable in accordance with its
terms.

          8.3  Validity of Contemplated Transactions.  The execution, delivery 
               -------------------------------------   
and performance by CNTO and CBV of this Amendment, and the consummation by them
of the transactions contemplated hereby, do not, and will not (a) violate or
contravene any provision of CNTO's or CBV's charter or bylaws; (b) violate,
breach, conflict with, constitute under, cause the acceleration of any payments
pursuant to, or otherwise impair the good standing, validity, or effectiveness
of, any agreement, contracts, indenture, lease, license, or mortgage to which
CNTO or CBV is a party, or by which CNTO or CBV or any of CNTO's or CBV's
properties or assets are bound; or (c) violate any provision of any law, permit
or court order applicable to CNTO or CBV.

                                      -6-
<PAGE>
 
          8.4  Litigation, Judgments, Orders, Etc.  Except as otherwise 
               -----------------------------------  
disclosed herein, in any Schedule or Exhibit hereto, or set forth in Schedule
8.4 hereto, no suit, action, proceeding or investigation is pending or, to the
knowledge of CNTO or CBV, threatened against CNTO or CBV or any of its
subsidiaries or affiliates, which, if determined adversely to such parties,
would (i) prohibit the execution or delivery of this Amendment or the ability of
CNTO or CBV to consummate the transactions contemplated hereby, (ii) prohibit
the issuance and sale of the Shares pursuant to this Amendment, or (iii) have a
Material Adverse Effect. Except as set forth in Schedule 8.4 hereto, CNTO or CBV
is not the subject of or bound by or otherwise affected by any outstanding
judgments or decrees of any court or governmental agency that would have a
Material Adverse Effect.

          8.5  Capitalization; Ownership of CBV.  CNTO's total authorized 
               --------------------------------   
capital stock consists of 100,000,000 shares of Common Stock, of which
67,692,301 shares were issued and outstanding on May 31, 1996, all of which have
been validly issued, and are fully paid and non-assessable, and 10,000,000
shares of Preferred Stock, none of which shares are presently issued. Since May
31, 1996, CNTO has not issued any shares of Common Stock other than shares of
Common Stock issued pursuant to existing Derivative Securities (as defined
below), as set forth on Schedule 8.5 hereto. Except for such existing Derivative
Securities, CNTO does not have outstanding any Derivative Securities or any
commitments to issue any Derivative Securities. For the purposes of this
Amendment, the term "Derivative Securities" shall have the meaning ascribed to
in under Rule 16a-1(c) as promulgated by the SEC under the 1934 Act. CBV is a
direct, wholly-owned subsidiary of CNTO.

          8.6  Issuance of the Shares.  The Shares, when issued and delivered to
               ----------------------                                           
Lilly pursuant to and in accordance with the terms of this Amendment, (a) will
have been validly issued, fully paid and non-assessable, (b) will be free and
clear of any liens, (c) will have been issued without violation of any
preemptive or other right to purchase Common Stock, and (d) based in part on
representations of Lilly in this Amendment, will have been issued in compliance
with all applicable federal and state securities laws.

          8.7  Other Securities and Financial Statement Matters.  CNTO has duly
               ------------------------------------------------                
filed in a timely manner (without any permitted extension) all reports required
to be filed by CNTO with the SEC under the 1934 Act (the "SEC Reports").  The
SEC Reports (including, in each case, without limiting the generality thereof,
the audited and unaudited financial statements of CNTO included therein) when
filed contained all statements required to be stated therein in accordance with
the 1934 Act and did not contain any untrue statement of material fact or omit
to state a material fact necessary to make any of the statements contained
therein not misleading in light of the circumstances under which they were made
and otherwise complied in all material respects with the applicable requirements
of the 1934 Act.  The consolidated financial statements included in the SEC
Reports comply as to form with the requirements of Regulation S-X, as
promulgated by the SEC under the 1933 Act and are derived from the applicable
books and records of CNTO, have been prepared in conformity with generally
accepted accounting principles (as required by Regulation S-X) and present
fairly the financial

                                      -7-
<PAGE>
 
condition, results of operations, changes in security holders' equity and cash
flows of CNTO on a consolidated basis, as at the close of business, or for the
period ended, on the date of each of such financial statements.

          8.8  Absence of Certain Changes or Events.  Except as disclosed in
               ------------------------------------                         
the financial statements referred to in Section 8.7 and CNTO's Annual Report on
Form 10-K for the year ended December 31, 1995 and CNTO's Quarterly Report on
Form 10-Q for the quarter ended March 31, 1996, or as otherwise disclosed
herein, in any Schedule or Exhibit hereto or listed on Schedule 8.8 hereto,
since March 31, 1996, neither CNTO nor any of its subsidiaries or affiliates has
incurred any liabilities or obligations, direct or contingent, or entered into
any transactions, not in the ordinary course of business, that are material to
CNTO and its subsidiaries and affiliates, taken as a whole, and there has not
been (i) any material change in the capital stock or indebtedness of CNTO or its
subsidiaries or affiliates that would have a Material Adverse Effect (as defined
below), or (ii) any event, change or occurrence which individually or in the
aggregate might (x) have a material adverse effect on the condition (financial
or other), assets, business, or results of operations of CNTO and its
subsidiaries and affiliates, taken as a whole, (y) materially adversely affect
CNTO's ability to consummate any of the transactions contemplated hereby or to
perform its obligations under this Amendment or the Agreement or (z) materially
adversely affect CNTO's or any of its subsidiaries' or affiliates' rights in or
to the HA-lA(TM) human monoclonal antibody pharmaceutical product known as
"Centoxin(R)" or the 7E3(TM) monoclonal antibody pharmaceutical product known as
"ReoPro(R)" (each of (x), (y) and (z) being referred to herein, individually or
in the aggregate as a "Material Adverse Effect").  Except for Derivative
Securities defined in Section 8.5 above, CNTO has not issued, or agreed to
issue, any securities or other instruments convertible into, exchangeable for or
exercisable into CNTO securities that would have a Material Adverse Effect.  No
event has occurred since March 31, 1996, with respect to which CNTO would be
required to file a Current Report on Form 8-K under the 1934 Act.

          8.9  Governmental Consents.  Except for the filing of the Registration
               ---------------------                                            
Statement, no consent, approval, order or authorization of, or registration,
qualification, designation, declaration or filing with, any federal, state or
local governmental authority in the United States on the part of CNTO and CBV is
required in connection with the consummation of the transactions contemplated by
this Amendment.

          8.10  Absence of Undisclosed Liabilities.  Except as disclosed in the
                ----------------------------------                             
financial statements referred to in Section 8.7, CNTO's Annual Report on Form
10-K for the year ended December 31, 1995 and CNTO's Quarterly Report on Form
10-Q for the quarter ended March 31, 1996 and as set forth in Schedule 8.10
hereto, there are no debts, liabilities or obligations, contingent or otherwise,
of CNTO or its subsidiaries or affiliates that would have a Material Adverse
Effect.

          8.11  Completeness of Disclosure.  Neither this Amendment, any 
                --------------------------
statements made by officers of CNTO or CBV nor any instruments or certificates
made or delivered by CNTO or CBV in connection herewith contains any untrue

                                      -8-
<PAGE>
 
statement of a material fact or omits to state a material fact necessary to make
the statements made herein or therein, in light of the circumstances under which
they were made, not misleading and the other documents delivered in connection
herewith, taken as a whole, together with such statements, instruments or
certificates do not contain any untrue statement of a material fact or omit to
state a material fact necessary to make the statements made herein or therein,
in light of the circumstances under which they were made, not misleading.

          8.12  Use of Form S-3.  CNTO currently meets the conditions necessary 
                ---------------   
for use of a registration statement on Form S-3 under the 1933 Act.

          8.13  Brokers and Finders.  CNTO has not employed any broker, finder,
                -------------------                                            
consultant or intermediary in connection with the transactions contemplated by
this Amendment who would be entitled to a broker's, finder's or similar fee or
commission in connection therewith or upon the consummation thereof.

     9.   Representations and Warranties of Lilly.
          --------------------------------------- 

          9.1   Organization and Good Standing.  Lilly is a corporation duly 
                ------------------------------   
organized and validly existing under the laws of the State of Indiana.

          9.2   Corporate Power and Authority; Enforceability.  Lilly has the
                ---------------------------------------------                
requisite power and authority (corporate and otherwise) to execute, deliver and
perform this Amendment and to consummate the transactions contemplated hereby.
The execution, delivery and performance by Lilly of this Amendment and the
consummation by Lilly of the transactions contemplated hereby have been duly
authorized by all necessary action (corporate or otherwise) on its part.  This
Amendment constitutes a legal, valid and binding obligation of Lilly,
enforceable in accordance with its terms.

          9.3   Validity of Contemplated Transactions.  The execution, delivery 
                -------------------------------------   
and performance by Lilly of this Amendment and the consummation by it of the
transactions contemplated hereby do not, and will not (a) violate or contravene
any provision of Lilly's charter or bylaws; (b) violate, breach, conflict with,
constitute a default under, cause the acceleration of any payments pursuant to,
or otherwise impair the good standing, validity, or effectiveness of, any
agreement, contract, indenture, lease, license, or mortgage to which Lilly is a
party or by which Lilly is bound; (c) violate any provision of any law, permit
or court order applicable to Lilly; or (d) require any permit or consent of any
governmental authority to be obtained by Lilly which has not been obtained.

          9.4   Litigation Compliance with Laws.  There is no litigation pending
                -------------------------------   
or, to Lilly's knowledge, threatened against or related to Lilly nor any failure
to comply with, violation of or any default under, any law, permit or court
the order applicable to Lilly, in each case which would have a material adverse
effect on the ability of Lilly to execute, deliver and perform this Amendment or
on the ability of Lilly to consummate the transactions contemplated hereby.


                                      -9-
<PAGE>

          9.5  1933 Act Representations.  Lilly is an "accredited investor" 
               ------------------------   
within the meaning of Regulation D as promulgated by the SEC under the 1933 Act.
Lilly has such experience in financial and business matters such that it is
capable of evaluating the merits and risks of purchasing the Shares. Lilly is
acquiring the Shares for its own account, with no present intention of
transferring, distributing or reselling the Shares, or any part thereof, all
without prejudice, however, to the rights of Lilly at any time, in accordance
with this Amendment, lawfully to sell or otherwise dispose of all or any part of
the Shares.

          9.6  Governmental Consents.  No consent, approval, order or 
               ---------------------   
authorization of, or registration, qualification, designation, declaration or
filing with, any federal, state or local governmental authority in the United
States on the part of Lilly is required in connection with the consummation of
the transactions contemplated by this Amendment.

          9.7  Completeness of Disclosure.  Neither this Amendment, any 
               --------------------------   
statements made by officers of Lilly nor any instruments or certificates made or
delivered by Lilly in connection herewith contains any untrue statement of a
material fact or omits to state a material fact necessary to make the statements
made herein or therein, in light of the circumstances under which they were
made, not misleading and the other documents delivered in connection herewith,
taken as a whole, together with such statements, instruments or certificates do
not contain any untrue statement of a material fact or omit to state a material
fact necessary to make the statements made herein or therein, in light of the
circumstances under which they were made, not misleading.

          9.8  Brokers and Finders.  Lilly has not employed any broker, finder,
               -------------------                                             
consultant or intermediary in connection with the transactions contemplated by
this Amendment who would be entitled to a broker's, finder's or similar fee or
commission in connection therewith or upon the consummation thereof.

     10.  Conditions to Closing.
          --------------------- 

          10.1 Conditions to Obligations of Centocor.  The obligations of 
               -------------------------------------   
Centocor to consummate the transactions contemplated by this Amendment at the
Closing shall be subject to the satisfaction or waiver by Centocor on or prior
to the Closing Date of the following conditions:

                 (a)   Accuracy of Representations and Warranties; Performance 
                       -------------------------------------------------------
of Covenants. Each of the representations and warranties of Lilly contained in
-------------
this Amendment shall be true and correct in all material respects when made and
as of the Closing Date, with the same effect as though such representations and
warranties had been made on and as of the Closing Date (except representations
and warranties that are made as of a specific date need be true in all material
respects only as of such date); each of the covenants and agreements of Lilly to
be performed on or prior to the Closing Date shall have been duly performed in
all material respects. 


                                      -10-
<PAGE>

                 (b)   No Order.  There shall not have been issued and be in 
                       --------       
effect any injunction (temporary or permanent), order, decree, judgment of or in
any court or tribunal of competent jurisdiction (an "Order") which prohibits the
consummation of the purchase and sale of the Shares or which materially
restricts Centocor's ability to achieve the benefits of the transactions set
forth in the Amendment.

          10.2 Conditions to Obligations of Centocor.  The obligations of Lilly
               -------------------------------------   
to consummate the transactions contemplated by this Amendment at the closing
shall be subject to the satisfaction or waiver by Lilly on or prior to the
Closing Date of the following conditions:

                 (a)   Accuracy of Representations and Warranties; Performance 
                       -------------------------------------------------------  
of Covenants. Each of the representations and warranties of Centocor contained 
------------
in this Amendment shall be true and correct in all material respects when made
and as of the Closing Date, with the same effect as though such representations
and warranties had been made on and as of the Closing Date (except
representations and warranties that are made as of a specific date need be true
in all material respects only as of such date); each of the covenants and
agreements of Centocor to be performed on or prior to the Closing Date shall
have been duly performed in all material respects.


                 (b)   No Order.  There shall not have been issued and be in 
                       --------      
effect any Order which prohibits the consummation of the purchase and sale of
the Shares or which materially restricts Lilly's ability to achieve the benefits
of the transactions set forth in the Amendment.

                 (c)   Consents.  Centocor shall have obtained all consents or 
                       --------      
approvals of any third party, if any, which are necessary for or in connection
with the execution and delivery of this Amendment or the performance of Centocor
under this Amendment.

                 (d)   Opinion of Counsel.  Lilly shall have received from Duane
                       ------------------
Morris & Heckscher, counsel for Centocor, an opinion dated as of the Closing
Date, in form and substance reasonably satisfactory to Lilly as described below
(an opinion of counsel from CNTO's in-house counsel, George D. Hobbs, with
respect to subsections (iii) and (iv) below is satisfactory to Lilly provided
the form and substance of such opinion remains the same as described below):

                    (i)    CNTO is a corporation duly organized, validly
existing and in good standing under the laws of its jurisdiction of
incorporation;

                    (ii)   CNTO has the requisite power and authority (corporate
and otherwise) to execute, deliver and perform this Amendment and to consummate
the transactions contemplated hereby. The execution, delivery and performance by
CNTO of this Amendment and the consummation by CNTO of the transactions
contemplated hereby, have been duly authorized by all necessary action
(corporate or otherwise) on its part. This Amendment constitutes a legal, valid
and binding obligation of CNTO, enforceable in accordance with its terms, 

 
                                      -11-
<PAGE>

subject, as to enforcement of remedies, to applicable bankruptcy, insolvency,
reorganization, moratorium or other similar laws affecting creditors' rights
generally and the availability of equitable remedies which are subject to the
discretion of the court before which any proceeding is brought;

                    (iii)  The execution, delivery and performance by CNTO and
CBV of this Amendment, and the consummation by them of the transactions
contemplated hereby, do not, and will not violate or contravene any provision of
CNTO's or CBV's Articles of Incorporation, Charter or bylaws;

                    (iv)   Except as otherwise disclosed herein, in any Schedule
or Exhibit hereto, or set forth in Schedule 8.4 hereto, such counsel is not
aware of any suit, action, proceeding or investigation pending or threatened
against CNTO or CBV or any of its subsidiaries or affiliates, which, if
determined adversely to such parties, would (i) prohibit the execution or
delivery of this Amendment, (ii) prohibit the issuance and sale of the Shares
pursuant to this Amendment, or (iii) have a Material Adverse Effect. To the best
of such counsel's knowledge, except as set forth in Schedule 8.4 hereto, CNTO or
CBV is not the subject of or bound by or otherwise affected by any outstanding
judgments or decrees of any court or governmental agency that would have a
Material Adverse Effect;

                    (v)    The Shares, when issued and delivered to Lilly
pursuant to and in accordance with the terms of this Amendment, (a) will have
been validly issued and will be fully paid and non-assessable, (b) will be free
and clear of any liens, (c) to such counsel's knowledge, will have been issued
without violation of any preemptive or other right to purchase Common Stock, and
(d) based in part on representations of Lilly in this Amendment, be issued in
compliance with all applicable federal and state securities laws; and

                    (vi)   CNTO currently meets the conditions necessary for
use of a registration statement on Form S-3 under the 1933 Act.

     11.  Indemnification.
          --------------- 

          (a)  In the event of any registration of any of the Shares under the 
1933 Act pursuant to this Amendment, Centocor (notwithstanding anything to the 
contrary in this Amendment, for purposes of this Section 11, Centocor shall 
mean CNTO and CBV each jointly and separately) shall indemnify and hold harmless
Lilly with respect to the sale of such Shares against and losses, claims, 
damages or liabilities, joint or several, to which Lilly may become subject 
under the 1933 Act or any other statute or at common law, insofar as such 
losses, claims, damages or liabilities (or actions in respect thereof) arise out
of or are based upon (i) any alleged untrue statement of any material fact
contained, in any registration statement under which such Shares were registered
under the 1933 Act pursuant to the provisions of Section 7 of this Amendment,
any preliminary prospectus or final prospectus contained therein, or any
summary prospectus issued in connection with any Shares being registered, or any
amendment or supplement thereto, or (ii) any alleged omission to state in any
such document a material fact required to be stated therein or necessary to make
the statements
                                      -12-
<PAGE>

therein not misleading, and shall reimburse Lilly for any legal or other 
expenses reasonably incurred by Lilly in connection with investigating or
defending any such loss, claims, damage, liability or action; provided, 
however, that Centocor shall not be liable to Lilly in any such case to the 
extent that any such loss, claim damage or liability arises out of or is based 
upon (i) any alleged untrue statements or alleged omissions made in such 
registration statement, prospectus, summary prospectus, prospectus or amendment
or supplement thereto that is made in reliance upon and in conformity with
written information furnished to Centocor by Lilly, as the case may be,
specifically for use therein, or (ii) any alleged untrue statement or alleged
omission in a preliminary prospectus if the final prospectus (or the final
prospectus as amended or supplemented before confirmation of sale) corrects such
alleged untrue statement or omission and a copy of the final prospectus (as so
amended or supplemented) was not sent or given to the person or persons alleging
such untrue statement or omission at or before the confirmation of any sale
thereto in any case where such delivery is required by the 1933 Act, unless the
failure to deliver the final prospectus (as so amended or supplemented) was the
result of non-compliance by Centocor with the requirements of the 1933 Act
pertaining to furnishing to each seller such numbers of copies of prospectus,
including a preliminary prospectus, and such other documents, as seller may
reasonably request in order to facilitate the public sale or other disposition
of the Shares owned by such seller. Such indemnity shall remain in full force
and effect regardless of any investigation made by or on behalf of Lilly, and
shall survive transfer or such Shares by Lilly.

          (b) Lilly shall indemnify and hold harmless, Centocor, its directors
and officers, and each other person, if any, who controls Centocor, against any
losses, claims, damages or liabilities, joint or several, to which Centocor or
any such director or officer, or any controlling person of Centocor may become
subject under the 1933 Act or any other statute or at common law, insofar as
such losses, claims, damages or liabilities (or actions in respect thereof)
arise out of or are based upon (i) any alleged untrue statement or any material
fact contained in any registration statement under which Shares belonging to
Lilly were registered under the 1933 Act, pursuant to Section 7 of this
Amendment, any preliminary prospectus or final prospectus contained therein, or
any summary prospectus issued in connection with any such Shares being
registered, or any amendment or supplement thereto, or (ii) any alleged omission
to state in any such document a material fact required to be stated therein or
necessary to make the statements therein not misleading, in the case of (i) or
(ii) to the extent, but only to the extent, that such alleged untrue statement
or alleged omission was made in such registration statement, preliminary
prospectus, summary prospectus, prospectus, amendment or supplement in reliance
upon and in conformity with written information furnished to Centocor by Lilly
specifically for the use therein, and then only to the extent that such alleged
untrue statements of alleged omissions by Lilly were not based on the authority
of an expert as to which Lilly had no reasonable ground to believe, and did not
believe, that the statements made on the authority of such expert were untrue or
that there was an omission to state a material fact, and shall reimburse
Centocor or such director, officer, or controlling person of Centocor for any
legal or other expenses reasonably incurred in connection with investigating or
defending any such loss, claim

                                      -13-
<PAGE>

damage, liability or action. Notwithstanding the provisions of this Section
11(b), the aggregate liability of Lilly pursuant to the foregoing indemnity
provisions shall not exceed the net proceeds (before deducting expenses)
received by Lilly and its affiliates from the Shares sold by it pursuant to such
registration.

          (c)  Indemnification similar to that specified in subparagraphs (a)
and (b) of this Section 11 shall be given by Centocor and Lilly (with such
modifications as shall be appropriate) covered by any registration or other
qualification of Shares under any federal or state securities law or regulation
other than the 1933 Act with respect to any such registration or other
qualification effected pursuant to the provisions of this Amendment.

          (d)  If the Indemnification provided for in this Section 11 is held by
a court of competent jurisdiction to be unavailable to an Indemnified Party
(hereinafter defined as in Section 11(e) hereof) with respect to any loss,
liability, claim, damage, or expense referred to therein, then the Indemnifying
Party (hereinafter defined as in Section 11(e) hereof) in lieu of indemnifying
such Indemnified Party hereunder, shall contribute to the amount paid or payable
by such Indemnified Party as a result of such loss, liability, claim, damage, or
expense in such proportion as is appropriate to reflect the relative fault of
the Indemnifying Party on the one hand and of the Indemnified Party on the other
in connection with the statements or omissions that resulted in such losses, 
liability, claim, damage, or expense as well as any other relevant equitable 
consideration. The relative fault of the Indemnifying Party and of the 
Indemnified Party shall be determined by reference to, among other things, 
whether the untrue or alleged untrue statement of a material fact or the 
omission to state a material fact relates to information supplied by the
Indemnifying Party or by the Indemnified Party and the parties' relative intent,
knowledge, access to information, and opportunity to correct or prevent such 
statement or omission.

          (e)  In the event Centocor or any holder of Shares receives a
complaint, claim or other notice of any loss, claim or damage, liability or act,
giving rise to a claim for indemnification or contribution under subparagraphs
(a), (b), (c) or (d) of this Section 11, the person claiming indemnification
(the "Indemnified Party") under any such subparagraph shall promptly notify the
person against whom indemnification is sought (the "Indemnifying Party") or such
complaint, notice, claim or action, and the Indemnifying Party shall have the
right to investigate and defend any such loss, claim, damage, liability or
action. The Indemnified Party shall have the right to employ separate counsel in
any such action and to participate in the defense thereof but the fees and
expenses of such counsel shall not be at the expense of the Indemnifying Party.
In no event shall the Indemnifying Party be obligated to indemnify any person
for any settlement of any claim or action effected without the Indemnifying
Party's written consent.

     12.  Regulatory Compliance.  Centocor shall comply with all applicable
          ---------------------                                            
regulatory requirements, including, without limitation, those provisions of
Article VIII of the Agreement relating to reporting Adverse Drug Events and
communications with regulatory agencies with respect to ReoPro in Japan, and if

                                     -14- 
<PAGE>

Centocor enters into any agreement with a third party relating to ReoPro in
Japan, Centocor shall use its best efforts to cause such third party to comply
with such requirements, including, if applicable, reporting of Adverse Drug
Events to Lilly.

     13.  Trademark Assignment.  Lilly hereby agrees to use its best efforts to
          --------------------                                                 
take any and all actions necessary to promptly transfer to Centocor, Lilly's
rights to the Japanese trademark application No. 89722/94 pertaining to "ReoPro"
in Japan, together with all goodwill associated therewith for use only in Japan.

     14.  Miscellaneous.
          ------------- 

          (a)  All references to the "Agreement" in any documents and
instruments executed by the parties in connection with the Agreement, shall be
deemed to refer to the Agreement as the same has been amended through the date
hereof, and as the same may be amended in the future.

          (b)  The parties hereto agree to do such further acts and to execute
and deliver to each other such additional agreements, instruments and documents
as may be reasonably required to carry out the purpose of this Amendment.

          (c)  This Amendment may be executed in any number of counterparts and
each such counterpart shall be deemed an original, but all such counterparts
shall constitute but one and the same agreement.

          (d)  The Agreement and this Amendment may be modified or amended by
the parties hereto only by a written agreement executed by the party against
whom a change is to be enforced.

          (e)  This Amendment shall be governed by and construed in accordance
with the internal laws of the Commonwealth of Pennsylvania, without regard to
conflicts of laws principles.

     15.  Ratification and Confirmation.  Except as amended hereby, all of the
          -----------------------------                                       
terms and provisions of the Agreement and documents executed in accordance
therewith shall remain in full force and effect and, except as expressly amended
hereby, are hereby ratified and confirmed. 
 

                                      -15-
<PAGE>

 
     IN WITNESS WHEREOF, the undersigned have caused this Amendment to be
executed by their duly authorized officers on the date first above written.


CENTOCOR, INC.



         /s/ Dominic J. Caruso
------------------------------------------------
By:     Dominic J. Caruso
Title:  Vice President of Finance and
        Chief Financial Officer

CENTOCOR B. V

         /s/ David P. Holveck
------------------------------------------------
By:      David P. Holveck
Title:   President and Chief Executive Officer of Centocor Inc,
         and Managing Director, Centocor, B.V.

ELI LILLY AND COMPANY

         /s/ Sidney Taurel
------------------------------------------------
By:      Sidney Taurel
Title:   President and Chief Operating Officer


                                     -16-