Cy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

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### UNITED STA**TES ENVIRONMENTA L PROTECTION A**  **GENCY**

**WA SHINGTON, D.C. 20460**  **OFFICE OF CHEMICAL SAFETY AND**

**POLLUTION PREVENTION**



### MEM **ORANDUM Date:**  30
- APR
- 20 12 **SUBJECT: Cyazofamid**  Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessments for the Section 3 Registration Action on Basil, Succulent Beans, the Fruiting Vegetable Group 8
- 10, the Leafy G reens Subgroup 4A, and the Tuberous and Corm Vegetable Subgroup 1C. **PC Code:** 085651 **DP Barcode:** D 397214 **Decision No.:** 456373 **Registration No. :**  71512
- 3 **Petition No.:** 1E7929 **Regulatory Action:** Section 3 Registration **Risk Assessment Type:** NA **Case No .:**  None T **XR No.:** NA **CAS No.:** 120116
- 88
- 3 **MRID No.:** None **40 CFR:** 180.601 **FROM :**  Nancy

Dodd, Chemist Registration Action Branch III (RAB3) Health Effects Division (HED ; 7509P) **THROUGH:** Thomas Bloem, Chemist

William Cutchin, Chemist Dietary Exposure Scien ce Advisory Council (DESAC) H ED (7509P) and Paula Deschamp, Branch Chief RAB3/HED (7509P) **TO:** Nancy

Tsaur, Chemist RAB3/HED (7509P) and Barbara Madden/Laura Nollen, RM #5 Risk Integration, Minor Use and Emergency Response Branch Registration Division ( 7505P)Cy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

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### Executive Summary Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments were conducted using the Dietary E xposure Evaluation Model DEEM
FCIDTM, Version 2.03 which use s food consumption data from the U.S. Department of Agriculture’s Continuing Survey s of Food Intakes by Individuals (CSFII) from 1994
- 1996 and 1998
. The analys es were performed to support Section 3 requests for uses on ba sil, succulent beans, the fruiting vegetable group 8
- 10, the leafy greens subgroup 4A, and the tuberous and corm vegetable subgroup 1C. Acute Dietary ( Food and Drinking Water) Exposure Results and Characterization T he conservative acute dietary (food + drinking water) exposure assessment was performed for females 13
- 49 y ears old onl y, since an acute endpoint of concern was not identified for the general population. The acute dietary (food and drinking water) exposure assessment is conservative, i.e., ba sed on the assumption that residues in all crops are at the tolerance levels and that 100% of the crops are treated (100% CT). All processing factors were set to 1x, based on the results of processing studies demonstrating that residues of cy azofamid in p rocessed commodities would not exceed the level in the raw agricultural commodity (RAC) tolerances , except that default processing factors were used for dried tomatoes and tomato juice since those commodities are not required to be anal yz ed in processing s tudies. The acute estimated drinking water concentration ( EDWC ) of 136.2 ppb was modeled using Tier 2 PRZM/EXAMS ( Pesticide Root Zone Model/Exposure Anal ys is Modeling Sy stem ) for residues in surface water from use on turf and ornamentals , which yielded th e highest acute EDWC considering all registered/proposed uses. The acute dietary risk assessment shows that the acute dietary risk estimates are below HED’s level of concern (i.e. , <100% of the acute population adjusted dose (aPAD ) ). The acute dietary ri sk estimate for females 13
- 49 ye ars old at the 95 th 

### percentile of exposure was 2. 5 % of the aPAD
. C hronic Dietary (Food and Drinking Water) Exposure Results and Characterization The chronic dietary (food and drinking water) exposure assessment is conser vative, i.e., based on the assumption that residues in all crops are at the tolerance levels and that 100% of the crops are treated (100% CT). All processing factors were set to 1x, based on the results of processing studies demonstrating that residues of cyazofamid in processed commodities would not exceed the level in the raw agricultural commodity (RAC) tolerances , except that default processing factors were used for dried tomatoes and tomato juice since those commodities are not required to be anal yz ed in processing studies. The chronic EDWC of 133.5 ppb was modeled using Tier 2 PRZM/EXAMS ( Pesticide Root Zone Model/Exposure Analy sis Modeling S ys tem ) for residues in surface water from use on turf and ornamentals , which yi elded the highest chronic EDWC considering all registered/proposed uses. The chronic dietary risk assessment shows that the chronic dietary

risk estimates are below HED’s level of concern (i.e. , <100% of the chronic population adjusted dose (cPAD ) ). For the general U.S. population , th e exposure for food and drinking water utilized <1% of the cPAD. The chronic dietary risk estimateCy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

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### for the highest reported exposed population subgroup , children (1
- 2 y ears old), utilized 1.5 % of the cPAD. C ancer Dietary (Food and Drinking Water) Expos ure Results and Characterization A cancer dietary

risk assessment was not conducted since cy azofamid is classified as “not likely to be carcinogenic to humans.” **I. Introduction**  Dietary risk assessment incorporates both exposure and toxicity of a given p esticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adj usted dose (PAD). The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty

or safet y factors. For acute and non
- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PA D. HED is generally concerned when estimated cancer risk exceeds one in one m illion
. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available In formation on Assessing Exposur e from Pesticides, A User’s Guide,” 21
- JUN
- 2000, web link: http://www.epa.gov/fedrgstr/EPA
- PEST/2000/July /Day
- 12/6061.pdf ; or see SOP 99.6 ( 20
- AUG
- 1999 ). The most recent d ietary

risk assessment for cyazofamid was conducted b y Roger Chesser ( 25
- MAY
- 2010, DP # D376585 ). **II. Residue Information**  Tolerances: Permanent tolerances are established in 40 CFR §180.601 on various raw agricultural commodities (RACs) at levels ranging from 0.02 ppm on potato to 12.0 ppm on turnip greens and the Brassica leafy greens subgroup 5 B. A tolerance with regional registration is established on grape at 1.5 ppm. Time
- limited tolerances under Section 18 have been established on dried basil at 1 44 ppm and fresh basil at 12 ppm; these tolerances will expire on 12/31/14. No tolerances have been established on livestock commodities. Compliance with all tolerances specified in 40 CFR §180.601 is to be determined b y measuring only the sum of cyazofamid and its metabolite CCIM, calculated as the stoichiometric equivalent of cyazofamid. Residues of Concern: The HED Metabolism Assessment Review Committee (MARC) determined in a meeting on 2/18/04 that the residues of concern for risk assessment are parent and CCIM in plants, parent only in rotational crops, and parent, CCIM, CCIM
AM, and CTCA in water. For livestock commodities, the proposed and established uses fall under 40 CFR §180.6(a)(3), i.e., there is no reasonable expectation of finite residue s in livestock commodities.Cy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

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### Residue Data U sed for Acute and Chronic Assessments The conservative acute and chronic analy ses assumed that cy azofamid residues are present in/on all proposed/registered food commodities at tolerance levels and that 100% of a ll commodities are treated. Adequate processing data are available for grapes (MRID 45409028), tomatoes (MRID 45409031), and potatoes (MRID 45409033 and MRID 46537730 ). The results of these studies indicate that combined residues of cy azofamid and CCIM i n processed commodities are not expected to exceed the tolerances on the raw agricultural commodities. Therefore, processing factors were set to 1x, except that default processing factors were used for dried tomatoes and tomato juice since those commoditi es are not required to be anal yz ed in processing studies
. The food residue data used in the acute and chronic anal ys es are summarized i n Table 1 below
. **Table 1. Residue Data Used in the Acute and Chronic Dietary Analyses for Cyazofamid. 1**  Commodity Reco mmended Tolerance (ppm) Percent Crop

Treated Processing Factors Bean, succulent 0.5 100 NA2 Bean, succulent, shelled 0.08 Leafy greens subgroup 4A 10 Basil, fresh leaves 30 Basil, dried leaves 144 3 Vegetable, tuberous and corm, subgroup 1C 0.02 Vegetable, fruiting, group 8
- 10 0.9 Dried tomato 14.3 Tomato juice 1.5 1 Ta ble 1 includes proposed crops/crop groups only. 2 NA = not applicable. 3 The time
- limited tolerance of 144 ppm, which is established under the Section 18, was used fo r dried basil leaves instead of the recommended Section 3 tolerance of 90 ppm. 

### III. **Drinking Water Data** The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) in the following memor andum: “ Estimated Drinking Water Concentrations of Cy azofamid and its Degradates of Concern CCIM, CCIM
- AM and CTCA, for Use in Human Health Risk Assessment: IR
- 4 Petition for the Use on Succulent Beans, Shelled Beans, Leafy Greens Subgroup 4A, Ba s il (Fres h and Dried Leaves), Tuberous and Corm Vegetables Subgroup 1C, and Fruiting Vegetables Group 8
- 10 ” ( J. Meléndez, 10
- FEB
- 2012, D P# D 396052 ) and incorporated directly into this dietary

assessment. Water residues were incorporated in the DEEM
FCID into the f

ood categories “water, direct, all sources” and “water, indirect, all sources.” As shown in Table 2 below, the acute value of 136.2 ppb and the non - cancer chronic value of 133.5 ppb were the EDWCs which were directly entered into the exposure model to assess the contributions from drinking water. These EDWCs were modeled using Tier 2 PRZM/EXAMS ( Pesticide Root Zone Model/Exposure Analy sis ModelingCy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

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### Sy stem ) for residues in surface water from use on turf and ornamentals, which had the highest seasonal rat es among the proposed and registered uses. Acute and chronic EDWCs in ground water as modeled by Tier 1 SCI
- GROW ( Screening Concentration in Ground Water) were lower (2.18 ppb)
. **Table 2. Surface/Ground Water EDWCs for Cyazofam id and its Major Degradat**  **es.**
**Scenario Chemical**  **Surface water EDWCs (ppb) Ground water**  **EDWC (ppb) Acute**  **(1 -**  **in -**  **10 yr. peak) Chronic**  **(1 -**  **in -**  **10 yr. m ean)**  1 st Scenario Parent 14.362 0.377 0.01180 2 nd Scenario CCIM 17.106 12.094 0.00061

CCIM
- AM 6.699 6.312 0.00270 3 rd Scen ario CTCA **136.242 133.458**  2.18000 

### The model and its description are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/
. **IV. DEEM**  **- FCIDTM Program and Consumption Information**  Cy azofamid acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM
- FCIDTM, Version 2.03 which incorpo rates consumption data from USDA’s Continuing Survey s of Food Intakes by Individuals (CSFII), 1994
- 1996 and 1998. The 1994
- 96, 98 data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as c onsumed” (e.g., apple pie) are linked to EPA
- defined food commodities (e.g. apples, peeled fruit
- cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly

by USDA/ARS an d EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on analy sis of the 1994
- 96, 98 CS FII consumption data, which took into account dietary

patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 y ear old), children 1
- 2, ch ildren 3
- 5, children 6
- 12, youth 13
- 19, adults 20
- 49, females 13
- 49, and adults 50+ ye ars old. For chronic dietary

exposure assessment, an estimate of the residue level in each food or food
- form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food f orms on the commodity

residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day

and as a percent of the cPAD. This procedure is performed for each population subgroup.Cy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

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### For acute exposure assessments, individual one
- day food consumption data are used on an individual
- by
- individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total daily pesticide exposure for a determinis tic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who repo rted eating relevant commodities/food forms) and a per
capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy , per capita exposure and risk are reported for all tiers of anal ys is . However, for tiers 1 and 2, any significant differences in user vs. per capita exposure and risk are specificall y identified and noted in the risk assessment. **V. Toxicological Information**  T he risk assessment team selected endpoints that were selected previousl y ( Ghazi Dannan, 15
- APR
- 2004 , TXR# 0052428, Cyazofamid [IKF
- 916]

– Report of the Hazard Identification Assessment Review Committee ). The HED cy azofamid risk assessment team has recommended that the FQPA Safet y Factor be reduced to 1X (D P# D 356837 , N. Tsaur, 20
- MAY
- 2009 ; D P# D 370671, N. Tsaur, 7
- APR
- 2010 ). In brief, th e toxicology database is adequate for the purpose of characterization of potential pre
- and postnatal risks to infants and children . The concern is low for the quantitative suscepti bility seen in the rat developmental toxicity study and there are no residual uncertainties. There were no indications of pre
- and / or postnatal toxicity and no residual uncertainties from the rabbit developmental study or the rat two
generation reproductio n study
. Although a subchronic neurotoxicity study is not available, the acute neurotoxicity study showed no neurotoxic effects. Neurotoxicity and immun otoxicity

were not demonstrated in the available studies. The dietary (food and water) and residentia l exposure assessments are conservative and are not likely to underestimate the potential exposures.Cy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

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Page 7 of 15 **T able**  **3 .**  **Summary of Toxicological Doses and Endpoints for Cyazofam id for Use in Dietary** 

**Exposure Risk Assessments. Exposure/**  **Scenario Point of** 

**Departure (PoD)**  **Uncertainty/**

**FQPA Safety Factors**  **RfD, PAD,**

**Level of Concern**  **Study and Toxicological Effects** Ac ute Dietary (General Population, including Infants and Children) No adverse effects were observed which could be attributed to a single
- dose exposure

for the general population
. Ac ute Dietary (Fem ales 13
- 49 years of age) NOAEL =

100 mg/kg/day UF A = 10X

UF H = 10X FQPA SF = 1X Ac ute RfD =

1.0 mg/kg/day aPAD = 1.0 mg/kg/day Rat Prenatal Developmental Toxicity

(MRID 45408933) LOAEL = 1,000 mg/kg/day based on developmental toxicity findings of increased incidence of bent ribs. Chronic Dietary (All Populations) NOAEL=

94.8 mg/kg/day UF A = 10X

UF H = 10X FQPA SF = 1X Chronic RfD =

0.9 5 mg/kg/day cPAD = 0.95 mg/kg/day 18
- Month Mouse Oral

Carcinogenicity (MRID 45 408932) LOAEL = 985 mg/kg/day based on increased skin lesions. Cancer (oral, dermal, inhalation) Classification: “Not likely to be Carcinogenic to Humans” based on the absence of

significant tumor increases in two adequate rodent carcinogenicity studies. Point of Departure (POD) = A data point or an estimated point that is derived from observed dose
- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human ( inter species). UF H = potential variation in sensitivity among member s of the human population (intra spe cies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. N/A = not applicable. 

### VI. **Results/Discussion** As stated above, for acute and chronic assessments, HED is concerned when dietary risk e x ceeds 100% of the PAD. The DEEM
- FCIDTM anal ys es estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 4 are for the general U.S. Population, all infants (<1 y ear old), children 1
- 2, children 3
- 5, children 6
- 12, youth 13
- 19, females 13
- 49, adults 20
- 49, and adults 50+ ye ars old
. Cancer risk is determined for the general U.S. population only
. Results of Acute Dietary ( Food and Drinking Water) Exposure Anal y s is An acute dietary

(food + drinking water) exposure assessment was performed for females 13
- 49 y ears old onl y, since an acute endpoint of concern was not identified for the general population. The acute dietary (food and drinking water) exposure assessment is conservative , i.e., based on the assumption that residues in all crops are at the tolerance levels and that 100% of the crops are treated (100% CT). The acute dietary risk assessment shows thatCy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

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### the acute dietary

risk estimates are below HED’s level of concern (i.e. , <100% of the acute population adjusted dose (cPAD ) ). The acute dietary risk estimate for females 13
- 49 ye ars old at the 95 th 

### percentile of exposure was 2. 5 % of the aPAD
. The results of the acute dietary

exposure analy sis are reported in T able 4 below
. Results of Chro nic Dietary ( Food and Drinking Water) Exposure Analy s is The chronic dietary (food and drinking water) exposure assessment is conservative, i.e., based on the assumption that residues in all crops are at the tolerance levels and that 100% of the crops are treated (100% CT). The chronic dietary risk assessment shows that the chronic dietary

risk estimates are below HED’s level of concern (i.e. , <100% of the chronic population adjusted dose (cPAD ) ). For the general U.S. population , the exposure for food and drinking water utilized <1% of the cPAD. The chronic dietary risk estimate for the highest reported exposed population subgroup , children (1
- 2 y ears old), was 1 .5 % of the cPAD. The results of the chronic dietary exposure anal ys is are reported in Table 4 below. **Tab le 4**  **. Summary of Dietary**  **(Food and Drinking Water) Exposure and Risk for**  **Cyazofam id**  **.** Population Subgroup Ac ute Dietary (95 th Percentile) Chronic Dietary Cancer Dietary Exposure (mg/kg/day) % aPAD* Dietary Exposure (mg/kg/day) % cPAD* Di etary Exposure (mg/kg/day) Risk General U.S. Population

NA 1 NA 0.008 157 <1% All Infants (< 1 year old) 0.012989 1.4

N/A N/A **Children 1 -**  **2 years old 0.014334**  **1.5** Children 3
- 5 y ears old 0.012 279 1.3 Children 6
- 12 y ears old 0.008139 <1% Youth 13
- 19 y ears old 0.0062 74 <1% Adults 20
- 49 y ears old 0.007 733 <1% Adults 50+ years old 0.007855 <1% Fem ales 13
- 49 y ears old 0.02 4799 2. 5 0.007 725 <1% 1 NA = Not Applicable 

### VII. **Characterization of Inp uts/Outputs**  The acute and chronic dietary exposure and risk estimates are conservative since they assume that 100% of the crops are treated with cyazofamid and that residues are present at tolerance levels. In addition, EDWCs w ere based on screening leve l estimates generated b y the PRZM
- EXAMS model. Dietary exposure estimates could be refinedCy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

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### through the use of anticipated residues and percent crop treated data, as well as refined estimated drinking water concentrations. However, since estimated exposur es and risks using conservative assumptions are well below the Agency ’s level of concern, such refinement is not warranted. **VIII. Conclusions**  These conservative dietary exposure anal ys es using DEEM
- FCIDTM indicate that acute and chronic dietary

exposures to cy azofamid from food and drinking water are well below the Agency ’s level of concern. Both assessments were conservative, i.e., the assessments assumed that residues in all crops were at tolerance levels and that 100% of the crops were treated. An acute endpoint was not identified for the general U.S. population. The estimated acute exposure of females 13
- 49 y ears old, the only population subgroup of concern for acute exposure, represents 2. 5 % of the aPAD at the 95 th 

### percentile of exposure. Estimated chronic dietary exposures are <1% of the cPAD for the general U.S. population and 1.5% of the cPAD for the highest reported exposed population subgroup , children (1
- 2 y ears old)
. **IX. List of Attachments** 

• Acute Food plus Water Residue Inp ut F ile.
• Acute R esults F ile.
• Chronic Food Residue Input F ile.
• Chronic Results F ile.

cc: N. Dodd (RAB3/HED); N. Tsaur (RAB3/HED)Cy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

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### Attachment 1. Acute Food plus Water Residue Input File Filename: C: \ Documents and Settings \ NDODD \ My Documents \ Deemfcidndodd \ Cyazofamd \ acute cyazofamid food+water 043012.R98 Chemical: cyazofamid RfD(Chronic): .95 mg/kg bw/day NOEL(Chronic): 94.8 mg/kg bw/day RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day Date created/last modified: 04
- 30 - 2012/13:35:46/8 Program ver. 2.03 Comment: Drinking water using turf & ornamentals inc. parent, CCIM, CCIM - AM

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Co mmodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 01010780 1AB Carrot 0.090000 1.000 1.000 01010781 1AB Carrot - babyfood 0.090000 1.000 1.000 01010790 1AB Carrot, juice 0.090000 1.000 1.000 01030150 1CD Arrowroot, flour 0.020000 1.000 1.000 01030151 1CD Arrowroot, flour - babyfood 0.020000 1.000 1.000 01030170 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 01030820 1CD Cassava 0.020000 1.000 1.000 01030821 1CD Cassava - babyfood 0.020000 1.000 1.000 01031390 1CD Dasheen, corm 0.020000 1.000 1.000 01031660 1CD Ginger 0.020000 1.000 1.000 01031661 1CD Ginger - babyfood 0.020000 1.000 1.000 01031670 1CD Ginger, dried 0.020000 1 .000 1.000 01032960 1C Potato, chips 0.020000 1.000 1.000 01032970 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000 01032971 1C Potato, dry (granules/ flakes)
- b 0.020000 1.000 1.000 01032980 1C Pot ato, flour 0.020000 1.000 1.000 01032981 1C Potato, flour - babyfood 0.020000 1.000 1.000 01032990 1C Potato, tuber, w/peel 0.020000 1.000 1.000 01032991 1C Potato, tuber, w/peel
- babyfood 0.020000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 01033001 1C Potato, tuber, w/o peel
- babyfood 0.020000 1.000 1.000 01033660 1CD Sweet potato 0.020000 1.000 1.000 0103 3661 1CD Sweet potato - babyfood 0.020000 1.000 1.000 01033710 1CD Tanier, corm 0.020000 1.000 1.000 01033870 1CD Turmeric 0.020000 1.000 1.000 01034060 1CD Yam, true 0.020000 1.000 1.000 01034070 1CD Yam bean 0.020000 1.000 1.000 04010050 4A Amaranth, leafy 10.000000 1.000 1.000 04010180 4A Arugula 10.000000 1.000 1.000 04011040 4A Chrysanthemum, garland 10.000000 1.000 1.000 04011330 4A Cress, garden 10.000000 1.000 1.000 04011340 4A Cress, upland 10.000000 1.000 1.000 04011380 4A Dandelio n, leaves 10.000000 1.000 1.000 04011500 4A Endive 10.000000 1.000 1.000 04012040 4A Lettuce, head 10.000000 1.000 1.000 04012050 4A Lettuce, leaf 10.00 0000 1.000 1.000 04012480 4A Parsley, leaves 10.000000 1.000 1.000 04013130 4A Radicchio 10.000000 1.000 1.000 04013550 4A Spinach 10.000000 1.000 1.000 04013551 4A Spinach - babyfood 10.000000 1.000 1.000 05010610 5A Broccoli 1.200000 1.000 1.000 05010611 5A Broccoli - babyfood 1.200000 1.000 1.000 05010620 5A Broccoli, Chinese 1.200000 1.000 1.000 05010640 5A Brussels sprouts 1.200000 1.000 1.000 05010690 5A Cabbage 1.200000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 1.200000 1.000 1.00 0 05010720 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 05010830 5A Cauliflower 1.200000 1.000 1.000 05011960 5A Kohlrabi 1.200000 1.000 1.000 05020630 5B Broccoli raab 12.000000 1.000 1.000 05020700 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 05021170 5B Collards 12.000000 1.000 1.000 05021940 5B Kale 12.000000 1.000 1.000 05022290 5B Mustard greens 12.000000 1.000 1.000 05023180 5B Rape greens 12.000000 1.000 1.000 05023890 5B Turnip, greens 12.000000 1.000 1.000Cy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

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Page 11 of 15 06010430 6A Bean, snap, succulent 0.500000 1.000 1.000 06010431 6A Bean, snap, succulent - babyfood 0.500000 1.000 1.000 06020310 6B Bean, broad, succulent 0.080000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.080000 1.000 1.000 06020370 6B Bean, lima, succulent 0.080000 1.000 1.000 08001480 8 Eggplant 0.900000 1.000 1.000 08002340 8 Okra 0.900000 1.000 1.000 0 8002700 8 Pepper, bell 0.900000 1.000 1.000 08002701 8 Pepper, bell - babyfood 0.900000 1.000 1.000 08002710 8 Pepper, bell, dried 0.900000 1.000 1.000 08002711 8 Pepper, bell, drie d - babyfood 0.900000 1.000 1.000 08002720 8 Pepper, nonbell 0.900000 1.000 1.000 08002721 8 Pepper, nonbell - babyfood 0.900000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.900000 1.0 00 1.000 08003740 8 Tomatillo 0.900000 1.000 1.000 08003750 8 Tomato 0.900000 1.000 1.000 08003751 8 Tomato - babyfood 0.900000 1.000 1.000 08003760 8 Tomat o, paste 0.900000 1.000 1.000 08003761 8 Tomato, paste - babyfood 0.900000 1.000 1.000 08003770 8 Tomato, puree 0.900000 1.000 1.000 08003771 8 Tomato, puree - babyfood 0 .900000 1.000 1.000 08003780 8 Tomato, dried 0.900000 14.300 1.000 08003781 8 Tomato, dried - babyfood 0.900000 14.300 1.000 08003790 8 Tomato, juice 0.900000 1.500 1.000 090107 50 9A Cantaloupe 0.100000 1.000 1.000 09010800 9A Casaba 0.100000 1.000 1.000 09011870 9A Honeydew melon 0.100000 1.000 1.000 09013990 9A Watermelon 0.100000 1.000 1.000 09014000 9A Watermelon, juice 0.100000 1.000 1.000 09020210 9B Balsam pear 0.100000 1.000 1.000 09020880 9B Chayote, fruit 0.100000 1.000 1 .000 09021020 9B Chinese waxgourd 0.100000 1.000 1.000 09021350 9B Cucumber 0.100000 1.000 1.000 09023080 9B Pumpkin 0.100000 1.000 1.000 09023090 9B Pumpkin, s eed 0.100000 1.000 1.000 09023560 9B Squash, summer 0.100000 1.000 1.000 09023561 9B Squash, summer - babyfood 0.100000 1.000 1.000 09023570 9B Squash, winter 0.1000 00 1.000 1.000 09023571 9B Squash, winter - babyfood 0.100000 1.000 1.000 19010280 19A Basil, fresh leaves 30.000000 1.000 1.000 19010281 19A Basil, fresh leaves - babyfood 30.000000 1.000 1.000 19010290 19 A Basil, dried leaves 144.000000 1.000 1.000 19010291 19A Basil, dried leaves - babyfood 144.000000 1.000 1.000 86010000 O Water, direct, all sources 0.136200 1.000 1.000 86020000 O Water, indirect, all sources 0.136200 1.000 1.000 95001750 O Grape 1.500000 1.000 1.000 95001760 O Grape, juice 1.500000 1.000 1.000 95001761 O Grape, juice - babyfood 1.500000 1.000 1.000 95001770 O Grape, leaves 1.500000 1.000 1.000 95001780 O Grape, raisin 1.500000 1.000 1.000 95001790 O Grape, wine and sherry 1.500000 1.000 1.000 95001880 O Hop 10.000000 1.000 1.000 95003800 O Tomato, Tree 0.900000 1.000 1.000Cy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 12 of 15 

### Attachment 2. Acute Results File. U.S. Environmental Protection Agency Ver. 2.02 DEEM - FCID ACUTE Ana lysis for CYAZOFAMID (1994 - 98 data) Residue file: acute cyazofamid food+water 043012.R98 Adjustment factor #2 used. Analysis Date: 04 - 30 - 2012/13:37:42 Residue file dated: 04
- 30 - 2012/13:35:46/8 NOEL (Acute) = 100.000000 mg/kg body - wt/day Daily totals for food and foodform consumption used. Run Comment: "Drinking water using turf & ornamentals inc. parent, CCIM, CCIM AM"

=============================================================================== Summary calculations (per capita): 95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- ------- - Females 13 - 49 yrs: 0.024799 2.48 4032 0.041882 4.19 2387 0.068117 6.81 1468Cy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 13 of 15 

### Attachment 3. Chronic Food Residue Input File. Filename: C: \ Documents and Settings \ NDODD \ My Documents \ Deemfcidndodd \ Cyazofamd \ chronic cyazofamid fo od+water 041912.R98 Chemical: cyazofamid RfD(Chronic): .95 mg/kg bw/day NOEL(Chronic): 94.8 mg/kg bw/day RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day Date created/last modified: 04
- 19 - 2012/14:21:55/8 Program ver. 2.03 Comment: Drink ing water using turf and ornamentals inc. only CTCA

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 01010780 1AB Carrot 0.090000 1.000 1.000 01010781 1AB Carrot - babyfood 0.090000 1.000 1.000 01010790 1AB Carrot, juice 0.090000 1.000 1.000 01030150 1CD Arrowroot, flour 0.020000 1.000 1.000 01030151 1CD Arrowroot, flour - babyfood 0.020000 1.000 1.000 01030170 1CD Artichok e, Jerusalem 0.020000 1.000 1.000 01030820 1CD Cassava 0.020000 1.000 1.000 01030821 1CD Cassava - babyfood 0.020000 1.000 1.000 01031390 1CD Dasheen, corm 0.02 0000 1.000 1.000 01031660 1CD Ginger 0.020000 1.000 1.000 01031661 1CD Ginger - babyfood 0.020000 1.000 1.000 01031670 1CD Ginger, dried 0.020000 1.000 1.000 01032960 1C Potato, chips 0.020000 1.000 1.000 01032970 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000 01032971 1C Potato, dry (granules/ flakes)
- b 0.020000 1.000 1.000 01032980 1C Potato, flour 0.020000 1.000 1.000 01032981 1C Potato, flour - babyfood 0.020000 1.000 1.000 01032990 1C Potato, tuber, w/peel 0.020000 1.000 1.000 01032991 1C Potato, tuber, w/peel
- babyfood 0.020000 1.000 1.00 0 01033000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 01033001 1C Potato, tuber, w/o peel
- babyfood 0.020000 1.000 1.000 01033660 1CD Sweet potato 0.020000 1.000 1.000 01033661 1CD Sweet potato - babyfood 0.020000 1.000 1.000 01033710 1CD Tanier, corm 0.020000 1.000 1.000 01033870 1CD Turmeric 0.020000 1.000 1.000 01034060 1CD Yam, true 0.020000 1.000 1.000 01034070 1CD Yam bean 0.020000 1.000 1.000 04010050 4A Amaranth, leafy 10.000000 1.000 1.000 04010180 4A Arugula 10.000000 1.000 1.000 04011040 4A Chrysanthemum, garland 10.000000 1.000 1.000 04011330 4A Cress, garden 10.000000 1.000 1.000 04011340 4A Cress, upland 10.000000 1.000 1.000 04011380 4A Dandelion, leaves 10.000000 1.000 1.000 04011500 4A Endive 10.000000 1.000 1.000 04012040 4A Lettuce, head 10.000000 1.000 1.000 04012050 4A Lettuce, leaf 10.000000 1.000 1.000 0 4012480 4A Parsley, leaves 10.000000 1.000 1.000 04013130 4A Radicchio 10.000000 1.000 1.000 04013550 4A Spinach 10.000000 1.000 1.000 04013551 4A Spinach - babyfood 10.000000 1.000 1.000 05010610 5A Broccoli 1.200000 1.000 1.000 05010611 5A Broccoli - babyfood 1.200000 1.000 1.000 05010620 5A Broccoli, Chinese 1.200000 1.0 00 1.000 05010640 5A Brussels sprouts 1.200000 1.000 1.000 05010690 5A Cabbage 1.200000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 05010720 5A Cabba ge, Chinese, mustard 1.200000 1.000 1.000 05010830 5A Cauliflower 1.200000 1.000 1.000 05011960 5A Kohlrabi 1.200000 1.000 1.000 05020630 5B Broccoli raab 12 .000000 1.000 1.000 05020700 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 05021170 5B Collards 12.000000 1.000 1.000 05021940 5B Kale 12.000000 1.000 1.000 050222 90 5B Mustard greens 12.000000 1.000 1.000 05023180 5B Rape greens 12.000000 1.000 1.000 05023890 5B Turnip, greens 12.000000 1.000 1.000Cy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 14 of 15 06010430 6A Bean, snap, succulent 0.500000 1.000 1.000 06010431 6A Bean, snap, succulent - babyfood 0.500000 1.000 1.000 06020310 6B Bean, broad, succulent 0.080000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.080000 1.000 1 .000 06020370 6B Bean, lima, succulent 0.080000 1.000 1.000 08001480 8 Eggplant 0.900000 1.000 1.000 08002340 8 Okra 0.900000 1.000 1.000 08002700 8 Pepper, be ll 0.900000 1.000 1.000 08002701 8 Pepper, bell - babyfood 0.900000 1.000 1.000 08002710 8 Pepper, bell, dried 0.900000 1.000 1.000 08002711 8 Pepper, bell, dried - babyfood 0.9000 00 1.000 1.000 08002720 8 Pepper, nonbell 0.900000 1.000 1.000 08002721 8 Pepper, nonbell - babyfood 0.900000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.900000 1.000 1.000 08003740 8 Tomatillo 0.900000 1.000 1.000 08003750 8 Tomato 0.900000 1.000 1.000 08003751 8 Tomato - babyfood 0.900000 1.000 1.000 08003760 8 Tomato, paste 0.900000 1.000 1.000 08003761 8 Tomato, paste - babyfood 0.900000 1.000 1.000 08003770 8 Tomato, puree 0.900000 1.000 1.000 08003771 8 Tomato, puree - babyfood 0.900000 1.000 1.000 08003780 8 Tomato, dried 0.900000 14.300 1.000 08003781 8 Tomato, dried - babyfood 0.900000 14.300 1.000 08003790 8 Tomato, juice 0.900000 1.500 1.000 09010750 9A Cantaloupe 0.100000 1.000 1.000 09010800 9A Casaba 0.100000 1.000 1.000 09011870 9A Honeydew melon 0.100000 1.000 1.000 09013990 9A Watermelon 0.100000 1.000 1.000 09014000 9A Watermelon, juice 0.100000 1.000 1.000 09020210 9B Balsam pear 0.100000 1.000 1.000 09020880 9B Chayote, fruit 0.100000 1.000 1.000 09021020 9B Ch inese waxgourd 0.100000 1.000 1.000 09021350 9B Cucumber 0.100000 1.000 1.000 09023080 9B Pumpkin 0.100000 1.000 1.000 09023090 9B Pumpkin, seed 0.100000 1.000 1.000 09023560 9B Squash, summer 0.100000 1.000 1.000 09023561 9B Squash, summer - babyfood 0.100000 1.000 1.000 09023570 9B Squash, winter 0.100000 1.000 1.000 090 23571 9B Squash, winter - babyfood 0.100000 1.000 1.000 19010280 19A Basil, fresh leaves 30.000000 1.000 1.000 19010281 19A Basil, fresh leaves - babyfood 30.000000 1.000 1.000 19010290 19A Basil, dried leaves 144.000000 1.000 1.000 19010291 19A Basil, dried leaves - babyfood 144.000000 1.000 1.000 86010000 O Water, direct, all sources 0.133500 1.000 1.000 86020000 O Water, indirect, all sources 0.133500 1.000 1.000 95001750 O Grape 1.500000 1.000 1.000 95001760 O Grape, juice 1.500000 1.000 1.000 95001761 O Grape, juice - babyfood 1.500000 1.000 1.000 95001770 O Grape, leaves 1.500000 1.000 1.000 95001780 O Grape, raisin 1.500000 1.000 1.000 95001790 O Grape, wine and sherry 1.500000 1.000 1.000 95001880 O Hop 10.0 00000 1.000 1.000 95003800 O Tomato, Tree 0.900000 1.000 1.000Cy azofamid Dietary Exposure and Risk Assessment DP Number: D397214

PC Code: 085651

______________________________________________________________________________________

Page 15 of 15 

### Attachment 4. Chronic Results File. U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for CYAZOFAMID (1994 - 98 data) Residue file name: C: \ Documents and Settings \ NDODD \ My Documents \ Deemfcidndodd \ Cyazofamd \ chronic cyazofamid food+water 041912.R98 Adjustment factor #2 NOT used. Analysis Date 04 - 26 - 2012/16:09:22 Residue file dated: 04
- 19 - 2012/14:21:55/8 Reference dose (RfD, Chronic) = .95 mg/kg bw/day COMMENT 1: Drinking water using turf and ornamentals inc. only CTCA

==================================================================== =========== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- -- ------------- U.S. Population (total) 0.008157 0.9% U.S. Population (spring season) 0.008177 0.9% U.S. Population (summer season) 0.008382 0.9% U.S. Population (au tumn season) 0.008035 0.8% U.S. Population (winter season) 0.008032 0.8% Northeast region 0.008203 0.9% Midwest region 0.008064 0.8% Southern region 0.007651 0.8% Western region 0.009020 0.9% Hispanics 0.008152 0.9% Non - hispani c whites 0.007995 0.8% Non - hispanic blacks 0.008239 0.9% Non - hisp/non
- white/non
- black 0.010614 1.1% All infants (< 1 year) 0.012989 1.4% Nursing infants 0.005056 0.5% Non - nursing infants 0.016000 1.7% Children 1 - 6 yrs 0.012576 1.3% Chil dren 7 - 12 yrs 0.007814 0.8% Females 13 - 19 (not preg or nursing) 0.006145 0.6% Females 20+ (not preg or nursing) 0.008154 0.9% Females 13 - 50 yrs 0.007838 0.8% Females 13+ (preg/not nursing) 0.006836 0.7% Females 13+ (nursing) 0.009165 1.0% Males 13 - 19 yrs 0.006349 0.7% Males 20+ yrs 0.007385 0.8% Seniors 55+ 0.007790 0.8% Children 1 - 2 yrs 0.014334 1.5% Children 3 - 5 yrs 0.012279 1.3% Children 6 - 12 yrs 0.008139 0.9% Youth 13 - 19 yrs 0.006274 0.7% Adults 20 - 49 yrs 0.007733 0.8% Adults 50+ yrs 0.007855 0.8% Females 13 - 49 yrs 0.007725 0.8%

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