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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C.  20549


                                ------------------
                                    FORM 10-Q
                                ------------------


(Mark  One)
[ x ]    Quarterly  report  pursuant to section 13 of 15(d) of the Securities
         Exchange Act of 1934 for the quarterly period ended March 31, 2001

[   ]    Transition  report  pursuant  to section  13 of 15(d) of the Securities
         Exchange Act of 1934 for the transition period from         to
                                                             --------   --------


                           Commission File No. 0-21038


                                NETWORK SIX, INC.
             (Exact name of registrant as specified in its charter)



        Rhode  Island                                                 05-0366090
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
 incorporation or organization)


                475 Kilvert Street, Warwick, Rhode Island  02886
          (Address of principal executive offices, including zip code)

                                 (401) 732-9000
              (Registrant's telephone number, including area code)


Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 of 15(d) of the Securities Exchange Act of 1934 during
the  preceding  12  months  (or  for such shorter period that the registrant was
required  to  file  such  reports),  and  (2)  has  been  subject to such filing
requirements  for  the  past  90  days.   Yes  X .   No    .
                                              ---       ---

As of March 31, 2001 there were 816,991 shares of the registrant's Common Stock,
$.10  par  value,  outstanding.

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                                        1
<PAGE>
<TABLE>
<CAPTION>
                         PART I - FINANCIAL INFORMATION

ITEM  1.  FINANCIAL  STATEMENTS


                                      NETWORK SIX, INC.
                                    CONDENSED BALANCE SHEETS

                                                                    Mar. 31, 2001     Dec. 31, 2000
ASSETS                                                               (unaudited)
                                                                   ----------------  ---------------
<S>                                                                <C>               <C>
Current assets
 Cash                                                              $     2,215,173   $    1,650,959
 Short term investments                                                  1,237,387        1,803,387
 Contract receivables, less allowance for
   doubtful accounts of $49,000 at March 31,
   2001 and December 31, 2000                                            1,408,075        1,094,142
 Costs and estimated earnings in excess of
   billings on contracts                                                   791,721          843,021
 Deferred taxes                                                            128,014          268,177
 Other current assets                                                      126,619           46,127
                                                                   ----------------  ---------------
     Total current assets                                                5,906,989        5,705,813
                                                                   ----------------  ---------------


Property and equipment
  Computers and equipment                                                  636,474          639,258
  Furniture and fixtures                                                   162,606          162,606
  Leasehold improvements                                                    20,191           20,190
                                                                   ----------------  ---------------
                                                                           819,271          822,054
Less: accum. depreciation and amortization                                 673,624          659,097
                                                                   ----------------  ---------------
       Net property and equipment                                          145,647          162,957

Deferred taxes                                                              59,555           79,701
Other assets                                                                35,161           47,007
                                                                   ----------------  ---------------
   Total Assets                                                    $     6,147,352   $    5,995,478
                                                                   ================  ===============


                                        2
<PAGE>
                                                                    Mar. 31, 2001     Dec. 31, 2000
                                                                     (unaudited)
                                                                   ----------------  ---------------
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
  Current portion of long-term debt:
    Vendors                                                        $       100,000   $      100,000
    Others                                                                 355,311          354,018
  Accounts payable                                                          85,407           31,023
  Accrued salaries and benefits                                            267,831          389,158
  Other accrued expenses                                                   134,047           93,021
  Billings in excess of costs and
     estimated earnings on contracts                                             -           19,048
  Preferred stock dividends payable                                      1,562,996        1,473,612
                                                                   ----------------  ---------------
    Total current liabilities                                            2,505,592        2,459,880
                                                                   ----------------  ---------------

Long-term debt, less current portion:
    Vendors                                                                442,239          442,239
    Others                                                                 389,795          416,618
                                                                   ----------------  ---------------
     Total Liabilities                                                   3,337,626        3,318,737
Stockholders' equity:
  Series A convertible preferred stock,
    $3.50 par value. Authorized 857,142.85
    shares; issued and outstanding 714,285.71
    shares at March 31, 2001 and December 31,
    2000; liquidation of $3.50 per share
    plus unpaid and accumulated dividends                                2,235,674        2,235,674
  Common stock, $.10 par value. Authorized
    4,000,000 shares; issued 825,684 shares
    at March 31, 2001 and 825,684 at
    December 31, 2000                                                       82,568           82,568
Additional paid-in capital                                               1,941,318        1,947,767
Treasury stock recorded at cost 8,693 shares
    at March 31, 2001 and 11,843 shares at
    December 31, 2000                                                      (32,511)         (44,360)
Retained earnings (accumulated deficit)                                 (1,417,323)      (1,544,908)
                                                                   ----------------  ---------------
     Total stockholders' equity                                          2,809,726        2,676,741
                                                                   ----------------  ---------------
     Total Liabilities & Stockholders' Equity                      $     6,147,352   $    5,995,478
                                                                   ================  ===============


                                        3
<PAGE>
                                          NETWORK SIX, INC.
                                     CONDENSED STATEMENTS OF INCOME
                                             (UNAUDITED)

                                                                     THREE MONTHS     THREE MONTHS
                                                                    ENDED 3/31/01     ENDED 3/31/00
                                                                   ----------------  ---------------


Contract revenue earned                                            $     2,946,953   $    2,856,038
Cost of revenue earned                                                   1,892,908        1,783,529
                                                                   ----------------  ---------------
     Gross profit                                                        1,054,045        1,072,509

Selling, general & administrative expenses                                 708,566          730,822
                                                                   ----------------  ---------------
     Income from operations                                                345,479          341,687
                                                                   ----------------  ---------------

Other deductions (income)
     Interest expense                                                       26,231           37,386
     Interest earned                                                       (48,546)         (35,334)
                                                                   ----------------  ---------------
          Income before income taxes                                       367,794          339,635

Income taxes                                                               150,825          139,251
                                                                   ----------------  ---------------
Net income                                                         $       216,969   $      200,384
                                                                   ================  ===============
Net income per share:
Basic                                                              $          0.16   $         0.15
                                                                   ================  ===============
Diluted                                                            $          0.16   $         0.15
                                                                   ================  ===============
Shares used in computing net income per share:
Basic                                                                      814,891          795,725
                                                                   ================  ===============
Diluted                                                                    814,891          795,725
                                                                   ================  ===============
Preferred dividends                                                $        89,384   $       84,144
                                                                   ================  ===============


                                        4
<PAGE>
                                              NETWORK SIX, INC.
                                       CONDENSED STATEMENTS OF CASH FLOW
                                                 (UNAUDITED)



                                                                      Three months    Three months
                                                                          ended         ended
                                                                        3/31/01        3/31/00
                                                                   ----------------  ---------------

  Net Income                                                       $       216,969   $      200,384
  Adjustments to reconcile net income to net cash
         provided by operating activities:
            Depreciation and amortization                                   23,117           22,445
            Changes in operating assets and liabilities:
            Contract receivables                                          (313,933)         460,442
            Cost and estimated earnings
                 in  excess of billings on contracts                        51,300         (429,737)
            Income taxes receivable                                              -           (4,080)
            Other current assets                                           (80,492)           4,033
            Deferred tax assets                                            160,309          139,250
            Other assets                                                    11,846           21,817
            Accounts payable                                                54,384          (91,473)
            Accrued salaries and benefits                                 (121,327)        (165,454)
            Other accrued expenses                                          41,026           39,827
            Billings in excess of costs
              and estimated earnings on contracts                          (19,048)         (31,051)
                                                                   ----------------  ---------------
                Net cash provided by operating activities                   24,151          166,403
                                                                   ----------------  ---------------


                                        5
<PAGE>
                                                                      Three months    Three months
                                                                          ended          ended
                                                                        3/31/01         3/31/00
                                                                   ----------------  ---------------

  Cash flows from investing activities:
    Purchases of property and equipment                                     (5,807)         (30,677)
   Proceeds from maturities of short-term investments                      566,000                -
                                                                   ----------------  ---------------
          Net cash provided (used in) investing activities                 560,193          (30,677)
                                                                   ----------------  ---------------

Cash flows from financing activities:
     Principal payments on capital lease obligations                             -           (8,132)
     Payments on long term debt                                            (25,530)         (24,353)
     Proceeds from issuance of common stock                                      -            6,151
     Sales (purchases) of treasury stock                                     5,400          (14,255)
                                                                   ----------------  ---------------
          Net cash (used in) financing activities                          (20,130)         (40,589)
                                                                   ----------------  ---------------
    Net increase in cash                                                   564,214           95,137
    Cash at beginning of period                                          1,650,959        2,453,935
                                                                   ----------------  ---------------
    Cash at end of period                                          $     2,215,173   $    2,549,072
                                                                   ================  ===============

Supplemental cash flow information:
         Cash paid during the period for:
                Income taxes                                       $        10,912   $            -
                Interest                                                    14,385           21,073
                                                                   ================  ===============
</TABLE>


                                        6
<PAGE>
                                NETWORK SIX, INC.
                          Notes to Financial Statements
                                 March 31, 2001
                                  (Unaudited)


(1)  Basis  of  Presentation

     The interim financial statements have been prepared without audit, pursuant
     to  the  rules  and  regulations  of the Securities and Exchange Commission
     (SEC).  Certain  information and footnote disclosures, normally included in
     financial  statements  prepared  in  accordance  with  generally  accepted
     accounting principles, have been condensed or omitted pursuant to SEC rules
     and  regulations;  nevertheless,  management  believes that the disclosures
     herein are adequate to make the information presented not misleading. These
     financial  statements  should  be  read  in  conjunction with the financial
     statements  and notes thereto included in the Form 10K and Proxy Statement.
     In  the  opinion  of management, all adjustments, consisting only of normal
     recurring  adjustments,  necessary to present fairly the financial position
     of  the Company as of March 31, 2001, and the statements of income and cash
     flows  for the three month periods ended March 31, 2001 and 2000, have been
     included  herein. The results of operations for the interim periods are not
     necessarily  indicative  of  the  results  for  the  full  years.

(2)  Under  the  requirements  in  Statement  of  Financial Accounting Standards
     (SFAS)  No.  128  for  calculating  basic  earnings per share, the dilutive
     effect  of  stock  options  and  warrants  are  excluded.

ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF  OPERATIONS

CAUTIONARY  STATEMENT  REGARDING  FORWARD-LOOKING  STATEMENTS

     This  report  contains  forward-looking statements reflecting the Company's
expectations  or  beliefs  concerning future events that could materially affect
Company performance in the future. All forward-looking statements are subject to
the  risks  and  uncertainties inherent with predictions and forecasts. They are
necessarily  speculative statements, and unforeseen factors, such as competitive
pressures,  litigation,  and  regulatory  and  state funding changes could cause
results  to  differ materially from any that may be expected. Actual results and
events  may  therefore  differ  significantly  from  those  discussed  in
forward-looking statements. Moreover, forward-looking statements are made in the
context  of  information  available  as  of  the  date  stated,  and the Company
undertakes  no  obligation  to  update  or revise such statements to reflect new
circumstances  or  unanticipated  events  as  they  occur.

GENERAL

     None

RESULTS  OF  OPERATIONS - THREE MONTHS ENDED MARCH 31, 2001 COMPARED TO 2001

     Contract  revenue  increased  $90,915  or  3%  from $2,856,038 in the three
months  ended  March  31, 2000 to $2,946,953 in the three months ended March 31,
2001,  primarily  due  to  increased  billings  on  the  State  of  Rhode Island
Department  of Human Services maintenance and support contract known as InRHODES
("InRHODES").  This revenue was partially offset by lower contract revenues from
certain  private  sector  accounts.


                                        7
<PAGE>
     Cost  of  revenue  earned,  consisting  of  direct  employee  labor, direct
contract  expense  and  subcontracting  expense,  increased  $109,379 or 6% from
$1,783,529  in  the three months ended March 31, 2000 to $1,892,908 in the three
months ended March 31, 2001. This was primarily related to higher revenues and a
higher  reliance  on subcontract labor, which is generally at a higher cost than
the  Company's  internal  staff.

     Gross  profit decreased $18,464 or 2%, from $1,072,509 for the three months
ended  March  31,  2000 to $1,054,045 for the three months ended March 31, 2001.
Gross  profit as a percentage of revenue earned decreased from 38% for the three
months  ended  March  31, 2000 to 36% for the three months ended March 31, 2001.
The  decrease  in  gross  profit  percentage  is due to higher costs relating to
increased use of subcontract labor, which is generally at a higher cost than the
Company's  internal  staff.

     Selling, general and administrative ("SG&A") expenses decreased $22,256, or
3%,  from  $730,822  in the three months ended March 31, 2000 to $708,566 in the
three  months  ended March 31, 2001, due to a decrease in marketing and business
development  staff  and  activities  as  a  result  of the Company's strategy to
re-focus  primarily  on  the  state government health and human services market.
This  was  offset  by  expenses  incurred in exploring strategic options for the
Company. On a percentage of revenues basis, SG&A expenses decreased from 26% for
the  three  months  ended March 31, 2000 to 24% for the three months ended March
31,  2001.

      Interest  expense  decreased  $11,155,  or 30%, from $37,386 for the three
months ended March 31, 2000 to $26,231 for the three months ended March 31, 2001
primarily  due  to  a  reduction  in  long-term  debt.

     Interest  income  increased  $13,212,  or 37%,  from $35,334, for the three
months ended March 31, 2000 to $48,546 for the three months ended March 31, 2001
due  to  increased  cash  and  short  term  investments.

     Income  before income taxes increased $28,159, or 8%, from $339,635 for the
three  months  ended March 31, 2000 to $367,794 for the three months ended March
31,  2001  primarily  due  to  the  lower  SG&A  expenses  described  above.

     Net  income  increased  $16,585,  or 8%, from $200,384 for the three months
ended  March  31,  2000  to  $216,969 for the three months ended March 31, 2001.

LIQUIDITY  AND  CAPITAL  RESOURCES

     In  order  to  finance  bid  preparation  costs  and  to  obtain sufficient
collateral  to support performance bonds required by some customers, the Company
has,  in  the  past,  entered  into joint ventures with other firms with greater
financial resources when bidding for contracts.  The Company continues to expand
this  practice  prospectively as well as pursue more time and material contracts
than it had historically pursued.  Time and materials contracts generally do not
require  performance  bonds and almost always involve less risk to meet customer
requirements.

     The  Company  has  historically  not  received  its first contract progress
payments  until  approximately  three  to six months after contract award, which
itself  was  as  much  as  12  months after proposal preparation commences.  The
Company was therefore required to fund substantial costs well before the receipt
of  related  income,  including  marketing  and proposal costs and the cost of a
performance  bond.

     The  Company  has funded its operations through cash flows from operations,
bank  borrowings,  borrowings  from  venture partners, and private placements of
equity  securities.  Net  cash  provided by operating activities was $24,151 and
$166,403  for  the  three  months  ended  March 31, 2001 and 2000, respectively.

     Fluctuations in net cash provided by operating activities are primarily the
result  of changes in net income, accounts receivable, accounts payable, accrued
salaries and benefits, and costs and estimated earnings in excess of billings on
contracts  due  to  differences  in  contract  milestones  and  payment  dates.


                                        8
<PAGE>
     On  September  21,  1998 the Company entered into two five-year term loans,
each  for  $250,000.  One  lender  was the Small Business Loan Fund Corporation,
("SBLFC"),  a  subsidiary  of the Rhode Island Economic Development Corporation.
The  other  lender  was  the  Business  Development  Corporation of Rhode Island
("BDC").  The  SBLFC  loan  carries  an annual interest rate of 9.5% and must be
repaid over five years.  The BDC loan carries an annual interest rate of 10.25%,
and  an  annual  deferred  fee of $5,000, and must be paid back over five years.
Both  term  loans  are  secured  by substantially all the assets of the Company,
subordinated  to the revolving line of credit with the commercial bank.  The BDC
was also issued five-year warrants to purchase 11,500 unregistered shares of the
Company's  Common  Stock  at a price of $4.50 per share.  The warrants expire on
September 20, 2003.  The fair value of the warrants was estimated by the Company
to  be $36,806 using the Black-Scholes model and is being amortized ratably over
the exercise period.  Such amount is included in other non-current assets on the
accompanying  balance  sheet.

     On  November  15, 1999, the Company entered into a revolving line of credit
with  a  commercial bank. This $1 million revolving line of credit is secured by
all  of  the  assets of the Company. The Company can borrow up to 80% of certain
qualified  accounts  receivable at an interest rate of prime plus 1/4%. On March
31,  2001,  the  revolving  line  of  credit had an outstanding balance of zero.

     The  Company  believes  that  cash  flow  generated  by  operations will be
sufficient  to  fund  continuing operations through the end of 2001. The Company
believes  that  inflation  has  not  had  a  material  impact  on its results of
operations  to  date.

RECENTLY  ISSUED  FINANCIAL  ACCOUNTING  STANDARDS

     There are no recently issued financial accounting standards that impact the
Company's  financial  statements.


                          PART II - OTHER INFORMATION

ITEM  1.  LEGAL  PROCEEDINGS

          None.

ITEM  2.  CHANGE  IN  SECURITIES

          None

ITEM  3.  DEFAULTS  UPON  SENIOR  SECURITIES

          None

ITEM  4.  SUBMISSION  OF  MATTERS  TO  A  VOTE  OF  SECURITY  HOLDERS

          None

ITEM  5.  OTHER  MATERIALLY  IMPORTANT  EVENTS

          None

ITEM  6.  EXHIBITS  AND  REPORTS


                                        9
<PAGE>
(a)  None

(b)  The  following  reports  on Form 8-K have been filed during the quarter for
which  this  report  is  filed.

     A  current  report  on  Form  8-K,  dated February 9, 2001 was filed by the
Company  and  included  the  press release dated February 8, 2001 announcing the
Company's  results  for  the  year  ended  December  31,  2000.  A  Statement of
Operations  (without  notes)  for the three month and twelve month periods ended
December  31, 2000 and 1999 and a Balance Sheet as of December 31, 2000 and 1999
was  also  included  with  the  filing.


                                       10
<PAGE>
                                   SIGNATURES


     Pursuant  to  the  requirements of the Securities Exchange Act of 1934, the
registrant  has  duly  caused  this  report  to  be  signed on its behalf by the
undersigned  thereunto  duly  authorized.


                                Network  Six,  Inc.

Date:  May  3,  2001            By:  /s/  Kenneth  C.  Kirsch
                                   ---------------------------------------------
                                   Kenneth  C.  Kirsch
                                   Chairman,  President  and
                                   Chief  Executive  Officer

                                By:  /s/  James  J.  Ferry
                                   ---------------------------------------------
                                   James  J.  Ferry
                                   Vice President of Finance and Administration,
                                      Chief  Financial  Officer  and  Treasurer
                                   (Principal Financial and Accounting Officer)


                                       11
<PAGE>