EX-4.1





 Exhibit 4.1 
  





 
 ZQ|CERT#|COY|CLS|RGSTRY|ACCT#|TRANSTYPE|RUN#|TRANS# ADD 3 ADD 2 ADD 1 ADD 4 ANY) (IFDE SIGNATION SAMPLE MR Louisville, 505006, BOX PO
5006-40233KY COMMON STOCK PAR VALUE $0.0001 
Certificate Number ZQ00000000 THIS CERTIFIES THAT PROMETHEUS BIOSCIENCES, INC. INCORPORATED UNDER THE LAWS OF THE STATE
OF DELAWARE ** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample ****
Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David 
Sample ****
Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr MR. Alexander.David SAMPLE Sample****Mr. Alexander David
& Sample MRS****Mr. Alexander. SAMPLE David Sample****Mr. Alexander & David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr Alexander David Sample ****
Mr. Alexander David Sample **** 
Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample ****
Mr. Alexander David Sample **** Mr. Alexander David Sample 
**** Mr. Alexander David MR Sample****.Mr. SAMPLE Alexander David
Sample****Mr. & Alexander MRS David Sample.**** SAMPLE Mr. Alexander David Sample**** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample ****
Mr. Alexander David Sample **** Mr. Alexander 
David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample ****
Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David
Sample **** 
Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample ****
Mr. Sample **** Mr. Sample 
COMMON STOCK 
Shares 
* * 0 0 0 0 0 0 * * * * * * * * * * * * * * * * * * 
* * * 0 0 0 0 0 0 * * * * * * * * * * * *
* * * * * 
* * * * 0 0 0 0 0 0 * * * * * * * * * * * * * * * * 
* * * * * 0 0 0
0 0 0 * * * * * * * * * * * * * * * 
* * * * * * 0 0 0 0 0 0 * * * * * * * * * * * * * * 
SEE REVERSE FOR CERTAIN DEFINITIONS 
CUSIP 74349U 10 8 
Transaction Total 1234567890/1234567890 1234567890/1234567890 1234567890/1234567890 1234567890/1234567890 1234567890/1234567890 1234567890/1234567890 Numbers Certificate DTC Shares
of Number Value Insurance ID Holder CUSIP/IDENTIFIER is the owner of **000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares 
****000000**Shares****000000**Shares***

*000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares 
****000000**Shares****000000**Shares**** 
000000**Shares
000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares 
****000000**Shares****0 THIS CERTIFICATE IS TRANSFERABLE
IN 
00000**Shares 000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000** hares****000000**Shares****00 
CITIES DESIGNATED BY THE TRANSFER

0000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares 
****000000**Shares****000000**Shares****000***ZERO HUNDRED THOUSAND

000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares 
****000000**Shares****000000**Shares****0000 AGENT, AVAILABLE ONLINE AT

00**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares 
****000000**Shares****000000 Shares****00000

0**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares 
****000000**Shares****000000 Shares****000000 www.computershare.com

**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares 
****000000**Shares****000000**Shares****000000*ZERO HUNDRED AND ZERO***

*Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares 
****000000**Shares****000000**Shares****000000**

Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares 
****000000**Shares****000000**Shares****000000**S 
FULLY-PAID AND NON-ASSESSABLE SHARES OF COMMON STOCK OF Prometheus Biosciences, Inc. (hereinafter called the “Company”), transferable on the books of the Company in person or by duly authorized attorney, upon surrender
of this Certificate properly endorsed. This Certificate and the shares represented hereby, are issued and shall be held subject to all of the provisions of the Certificate of Incorporation, as amended, and the
By-Laws, as amended, of the Company (copies of which are on file with the Company and with the Transfer Agent), to all of which each holder, by acceptance hereof, assents. This Certificate is not valid unless
countersigned and registered by the Transfer Agent and Registrar. Witness the facsimile seal of the Company and the facsimile signatures of its duly authorized officers. 
7666555444333222111 Total. Denom. Num/No 1234567890123451234567812345600.1,000,000 XXXXXXXXXXXXXXXXXXX Chief Financial Officer General Counsel & Secretary S IO S C B U I
RPORA E H E T N O C T C E E E S M , I O N R C P 10/26/2016 . D E E R LAWA DATED DD-MMM-YYYY COUNTERSIGNED AND REGISTERED: COMPUTER SHARE TRUST COMPANY, N.A. TRANSFER
AGENT AND REGISTRAR, By AUTHORIZED SIGNATURE 












 



 
 PROMETHEUS BIOSCIENCES, INC. 
THE COMPANY WILL
FURNISH WITHOUT CHARGE TO EACH SHAREHOLDER WHO SO REQUESTS, A SUMMARY OF THE POWERS, DESIGNATIONS, PREFERENCES AND RELATIVE, PARTICIPATING, OPTIONAL OR OTHER SPECIAL RIGHTS OF EACH CLASS OF STOCK OF THE COMPANY AND THE QUALIFICATIONS, LIMITATIONS OR
RESTRICTIONS OF SUCH PREFERENCES AND RIGHTS, AND THE VARIATIONS IN RIGHTS, PREFERENCES AND LIMITATIONS DETERMINED FOR EACH SERIES, WHICH ARE FIXED BY THE CERTIFICATE OF INCORPORATION OF THE COMPANY, AS AMENDED, AND THE RESOLUTIONS OF THE BOARD OF
DIRECTORS OF THE COMPANY, AND THE AUTHORITY OF THE BOARD OF DIRECTORS TO DETERMINE VARIATIONS FOR FUTURE SERIES. SUCH REQUEST MAY BE MADE TO THE OFFICE OF THE SECRETARY OF THE COMPANY OR TO THE TRANSFER AGENT. THE BOARD OF DIRECTORS MAY REQUIRE THE
OWNER OF A LOST OR DESTROYED STOCK CERTIFICATE, OR HIS LEGAL REPRESENTATIVES, TO GIVE THE COMPANY A BOND TO INDEMNIFY IT AND ITS TRANSFER AGENTS AND REGISTRARS AGAINST ANY CLAIM THAT MAY BE MADE AGAINST THEM ON ACCOUNT OF THE ALLEGED LOSS OR
DESTRUCTION OF ANY SUCH CERTIFICATE. 
The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they
were written out in full according to applicable laws or regulations: 
TEN COM—as tenants in common UNIF GIFT MIN ACT Custodian (Cust) (Minor) TEN ENT - as
tenants by the entireties under Uniform Gifts to Minors Act (State) 
JT TEN - as joint tenants with right of survivorship UNIF TRF MIN ACT -. Custodian (until age )

and not as tenants in common (Cust) under Uniform Transfers to Minors Act (Minor) (State) 
Additional abbreviations may also be used though not in the above list. 
PLEASE INSERT SOCIAL
SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE 
For value received, hereby sell, assign and transfer unto 
(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING POSTAL ZIP CODE, OF ASSIGNEE) of the common stock represented by the within Certificate, and do hereby irrevocably constitute
and appoint 
to transfer the said stock on the books of the within-named Company with full power of substitution in the premises. 
Dated: 20 
Signature: 
Signature: 
Notice: The signature to this assignment must correspond with the name as written
upon the face of the certificate, in every particular, without alteration or enlargement, or any change whatever. 
Signature(s) Guaranteed: Medallion Guarantee
Stamp 
THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (Banks, Stockbrokers, Savings and Loan Associations and Credit Unions) WITH
MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM, PURSUANT TO S.E.C. RULE 17Ad-15. 
The IRS requires that the
named transfer agent (“we”) report the cost basis of certain shares or units acquired after January 1, 2011. If your shares or units are covered by the legislation, and you requested to sell or transfer the shares or units using a
specific cost basis calculation method, then we have processed as you requested. If you did not specify a cost basis calculation method, then we have defaulted to the first in, first out (FIFO) method. Please consult your tax advisor if you need
additional information about cost basis. 
If you do not keep in contact with the issuer or do not have any activity in your account for the time period specified by
state law, your property may become subject to state unclaimed property laws and transferred to the appropriate state.