**Exhibit        10.5**

**AMENDMENT        NO. 1 TO**

**PRODUCT        LICENSE AND ASSIGNMENT AGREEMENT**

| A. | Cytogen                  and Inpharma entered into a Product License and Assignment Agreement                  dated                  as of October 11, 2006 (the “License                  Agreement”). |
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| B. | Cytogen                  and Inpharma wish to amend the terms of the License Agreement as                  set forth                  below in accordance with Section 9.05 of the License                  Agreement. |
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|   | 1. | Any                  defined terms utilized herein and not otherwise defined herein                  shall have                  the meaning ascribed thereto in the License                  Agreement. |
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|   | 2. | The                  first sentence of Section 2.04(a) is hereby amended to provide                  in its                  entirety as follows: “Inpharma hereby grants to Cytogen the exclusive                  options to acquire the exclusive licenses to market, distribute,                  sell and                  otherwise commercialize and Exploit the Product in each of Europe                  and Asia                  (the “Options”).” |
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|   | 3. | Section                  3.04 of the License Agreement is hereby amended to provide in its                  entirety                  as follows: |
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|   | 4. | The                  Parties understand and agree that the execution of this Amendment                  does not                  extend the term of the Options set forth in Section 2.04 of the                  License                  Agreement beyond [**]. |
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|   | 5. | Except                  as expressly provided in this Amendment, all other terms, conditions                  and                  provisions of the License Agreement shall continue in full force                  and                  effect as provided therein. Any reference to the License Agreement                  in any                  instrument or agreement shall mean and include the License Agreement                  as                  amended by this Amendment.  In the event of any conflict between                  the terms of the License Agreement and the terms of this Amendment,                  the                  terms of this Amendment shall govern and                  control. |
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|   | 6. | The                  License Agreement and this Amendment constitute the entire understanding                  between the parties, except as expressly set forth herein, and                  supersede                  any contracts, agreements or understanding (oral or written) of                  the                  parties with respect to the subject matter hereof.  No term of                  this Amendment may be amended except upon written agreement of                  both                  parties. |
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|   | 7. | This                  Amendment may be executed in one or more counterparts, each of                  which will                  be deemed an original but all of which together will constitute                  one and                  the same instrument. |
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**CYTOGEN        CORPORATION**

**INPHARMA        AS**

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