Exhibit 10.80



AGREEMENT REGARDING CONVERSION OF PROMISSORY NOTE



THIS AGREEMENT dated as of July 29, 2005, by and between Biovest International, Inc. a Delaware corporation (Biovest) and
John Lignos and Maria Lignos who are the Holders of Certain Convertible Promissory Note(s) convertible into Biovest Common Stock (hereinafter Holder), is as follows:



WHEREAS Biovest and Holder understand and acknowledge that Biovest Common Stock is in the process of being listed for sale on the NASD Over
the Counter-Bulletin Board for public trading; and



WHEREAS it is in the
interest of both Biovest and Holder that the number of shares of Common Stock of Biovest that are subject to contingent issuance under Warrants and Convertible Notes (Overhang) be consistent with comparable public companies in order to
be able to sustain a good market value accurately reflecting the companys actual value and the potential of its future growth and success; and



WHEREAS both Biovest and Holder acknowledge and agree that the existence of large outstanding Overhang creates uncertainty and a potentially destabilizing influence on
the market value of Biovest Common Stock, which tends to prevent the maintenance of a trading price accurately reflecting the value of Biovest;



NOW THEREFORE, for good and valuable consideration, receipt of which is hereby mutually acknowledged, the parties hereby agree as follows:



1. Subject to the terms contained herein, Holder hereby irrevocably covenants and agrees to
convert the entire outstanding balance (Principal and all accrued interest) due on Holders Promissory Notes as particularly identified on the attached Exhibit A into Common Stock of Biovest at $0.75 per share. The foregoing provision replaces
and supersedes all provisions regarding conversion rights into Biovest Common Stock contained in Holders Convertible Promissory Note(s).



2. Holder hereby covenants and agrees to convert the entire balance, including accrued interest on each of the Convertible Promissory Notes set forth on Exhibit A within
30 days of the date of this Agreement contingent upon and subject only to the following:

A. Biovests commencement of trading on the Over the
Counter-Bulletin Board ;

B. Holders previously having converted this Note(s) into Accentia Common Stock in accordance with the terms of the
Convertible Note(s).



3. Biovest agrees to issue to Holder and Holder
agrees to accept from Biovest in full and complete satisfaction of all rights and obligations pursuant to the Convertible Promissory Note(s) identified in Exhibit A hereto the number of shares of Biovest Common Stock set forth on Schedule B hereto,
which shares shall be fully-paid and non-assessable.



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4. Biovest and Holder acknowledge and agree that either the Biovest Common Stock (or, in the event that Holder elects to
convert into Accentia Common Stock as set forth in paragraph 2(b),the Accentia Common Stock) issued pursuant to this Agreement may bear a restrictive legend stating that the shares are not registered securities under the Securities Act of 1933, as
amended, or any state securities laws, unless Holder qualifies for an exemption from said restrictions.



5. Representations:



A. Holder acknowledges and represents that Holder has had access to all reports filed with the SEC by Biovest;



B. Holder is an Accredited Investor as defined in Regulation D promulgated under
the Securities Act of 1933, as amended, (ii) Holder has the financial ability to bear the economic risk of Holders investment as contemplated by this Agreement, and (iii) Holder was given the opportunity to ask questions to (and
received satisfactory answers from) Biovest regarding the terms and conditions of this Agreement;



C. Other than as specifically set forth herein, there have been no representations or warranties made by either party to the other.



6. Holder and Biovest hereby agree to submit any dispute that may arise pursuant to this agreement to arbitration under the auspices of the
American Arbitration Association Rules of Commercial Arbitration, to be venued in Tampa, FL. This agreement is subject to final approval by the Board of Directors of Biovest.



|                            |  |                   |  |           |  |                 
|--------------------------- |  | ----------------- |  | --------- |  | ----------------
|Biovest International, Inc. |  | Holder           
|                            |  |                   | 
|                            |  |                   |  | Signature |  | /s/ John Lignos 
|                            |  |                   |  |           |  | John Lignos     
|                            |  |                   | 
|By:                         |  | /s/ James McNulty |  | Signature |  | /s/ Maria Lignos
|                            |  |                   |  |           |  | Maria Lignos    
|Name:                       |  | James McNulty     |  |           |  |                 
|Title:                      |  | CFO               |  | Date:     |  | 8/23/05         
|Date:                       |  | 9/30/05           |  |           |  |                 







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EXHIBIT A



1. Promissory Note dated November 6, 2001 in the Principal Amount of $25,000.

2. Promissory Note dated December 3, 2002 in the Principal Amount of $25,000.



Schedule B



Biovest shall issue a total
of 81,432 shares of Common Stock, fully-paid and non-assessable, in full conversion and satisfaction of all sums due and obligations owed pursuant to the Note set forth above.