**Exhibit21**

 

**As of 12/31/05**

**LIST OFSUBSIDIARIES OF CHIRON CORPORATION**

 
| **SUBSIDIARY**                                                    | ** ** | **JURISDICTION  OF INCORPORATION  OR ORGANIZATION** |
|-------------------------------------------------------------------|------------|-----------------------------------------------------|
|                                                              |       |                                                |
| Cetus Generic  Corporation                                        |       | Delaware, USA                                       |
| Chiron Partners, Inc.                                             |       | California, USA                                     |
| Chiron Alpha  Corporation                                         |       | California, USA                                     |
| Chiron Properties, Inc.                                           |       | California, USA                                     |
| Chiron Delta  Corporation                                         |       | Delaware, USA                                       |
| Chiron Investment  Corporation                                    |       | Nevada, USA                                         |
| Chiron Mimotopes U.S.                                             |       | California, USA                                     |
| Chiron Redevelopment  Corporation                                 |       | Missouri, USA                                       |
| Chiron Foreign Sales  Corporation                                 |       | U.S. Virgin Islands                                 |
| Biocent Insurance  Company, Inc.                                  |       | Hawaii, USA                                         |
| Chiron AB                                                         |       | Sweden                                              |
| Chiron Behring Vaccines  Private Limited (51%)                    |       | India                                               |
| Chiron Technologies  Pty. Ltd.                                    |       | Australia                                           |
| Chiron B-1 Limited(1)                                             |       | Bermuda                                             |
| Chiron Overseas Holding  Co.                                      |       | Nevada, USA                                         |
| Sagres Discovery, Inc.                                            |       | Delaware, USA                                       |
| MemRex  Corporation                                               |       | Delaware, USA                                       |
| Prion Solutions, Inc.                                             |       | California, USA                                     |
| Chiron  B-2 Limited (1)                                           |       | Bermuda                                             |
| Chiron  Blood Testing (Bermuda) Ltd.                              |       | Bermuda                                             |
| Chiron  Vaccines LLC                                              |       | Delaware, USA                                       |
| Chiron  B.V.                                                      |       | The Netherlands                                     |
| Chiron  Blood Testing B.V.                                        |       | The Netherlands                                     |
| AlgoRx  Pharmaceuticals Inc. (~4.3%)                              |       | Delaware, USA                                       |
| Bavarian  Nordic AS (~3.46%)                                      |       | Denmark                                             |
| Chiron  Canada ULC/Chiron Canada SRI                              |       | Canada                                              |
| Chiron  Healthcare SAS                                            |       | France                                              |
| Chiron  Limited                                                   |       | Hong Kong                                           |
| Chiron  Vaccines Holdings Limited                                 |       | United Kingdom                                      |
| Chiron  Pharmaceuticals Limited                                   |       | United Kingdom                                      |
| Chiron  Vaccines Limited                                          |       | United Kingdom                                      |
| Chiron  Vaccines Australia Pty Ltd                                |       | Australia                                           |
| EPS  Vaccines Limited                                             |       | United Kingdom                                      |
| Chiron  Technologies Limited                                      |       | United Kingdom                                      |
| PowderChek  Diagnostics, Inc. (19.9%)(2)                          |       | Delaware, USA                                       |
| Chiron  Healthcare Ireland Limited dba “Chiron Ireland” |       | Ireland                                             |
| Chiron  Blood Testing Pty Ltd                                     |       | Australia                                           |

 

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(1) Chiron B-1 Limited and Chiron B-2 Limited entered into apartnership called Chiron Blood Testing (Bermuda) Ltd. on 12/18/2002; as of12/31/04, Chiron B-1 holds an 82% partnership interest, and Chiron B-2 holds an18% partnership interest. Together, the 2 entities jointly own Chiron BloodTesting (Bermuda) Ltd. and the subsidiaries listed thereunder.

 

(2) Chiron Corporation acquired a minority interest in thisprivately-held corporation when PowderJect Technologies BV was liquidated as of12/15/04; shareholding confers no special rights and warrants have no votingpower; remaining outstanding shares of PDI are held by PowderJect Technologies,Inc. (PTI) management and outside counsel to PTI.

 

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| **SUBSIDIARY**                                                                                                                                                                                                                       | ** ** | **JURISDICTION  OF INCORPORATION  OR ORGANIZATION** |
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|------------|-----------------------------------------------------|
|                                                                                                                                                                                                                                 |       |                                                |
| PathoGenesis  Portugal –Produtos Farmaceuticos, Sociedade Unipessoal Lda.                                                                                                                                                       |       | Portugal                                            |
| Chiron Iberia S.L.                                                                                                                                                                                                                   |       | Spain                                               |
| Appold Consultadoria E  Serviços,Sociedade Unipessoal, Lda                                                                                                                                                                      |       | Portugal                                            |
| Chiron Blood  Testing, S.De R.L. de C. V. [Appold-Consultadoria E Servicos (Sociedade  Unipessoal), LDA- 75%;Chiron B.V. – 25%]                                                                                                 |       | Mexico                                              |
| Chiron  Holding LLC                                                                                                                                                                                                                  |       | Delaware, USA                                       |
| Chiron  Hungary Üzleti Szolgáltató Korlátolt Felelősségű Társaság (aka  Chiron Hungary Kft.) or Chiron Hungary Business Services Limited Liability  Company (aka Chiron Hungary Ltd)(3) |       | Hungary                                             |
| Chiron  Vaccines Holding Srl(4)                                                                                                                                                                                                      |       | Italy                                               |
| Chiron  Srl                                                                                                                                                                                                                          |       | Italy                                               |
| Istituto  Vaccinogeno Pozzi Srl                                                                                                                                                                                                      |       | Italy                                               |
| Chiron  Funding LLC (0.01%)                                                                                                                                                                                                          |       | Delaware, USA                                       |
| Chiron  Panacea Vaccines Private Limited (50%)                                                                                                                                                                                       |       | India                                               |
| Chiron  Corp. s.r.o. [ Chiron Vaccines Holding Srl, 75%; Chiron Behring GmbH & Co  KG, 25%]                                                                                                                                      |       | Czech Republic                                      |
| Chiron  Behring Verwaltungsgesellschaft mbH                                                                                                                                                                                          |       | Germany                                             |
| Chiron  Behring GmbH & Co KG(5)                                                                                                                                                                                                  |       | Germany                                             |
| Chiron  GmbH                                                                                                                                                                                                                         |       | Germany                                             |
| Chiron  Biotecnologia Limitada Brazil                                                                                                                                                                                                |       | Brazil                                              |
| Rocamadour  – Consultadoria e Servicos, Sociedade Unipessoal, Lda                                                                                                                                                               |       | Portugal                                            |
| Chiron Investment  Company Spain, Srl (ETVE)                                                                                                                                                                                         |       | Spain                                               |
| Chiron  Corporation Limited                                                                                                                                                                                                          |       | United Kingdom                                      |
| Chiron  Italia S.r.l                                                                                                                                                                                                                 |       | Italy                                               |
| Chiron  France S.A.S. (formerly S.a.r.l.)                                                                                                                                                                                            |       | France                                              |

 

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(3) Appold holds a 99.4% interest and Chiron Holding LLC holds a 0.6%interest.

(4) Appold holds a 93% interest and Chiron Holding LLC holds a 7%interest.

(5) Effective 08/29/05, 31 Corsa Verwaltungsgesellschaft mbH, Germanymerged into Chiron Vacccines International Srl & Co KG, Germany; which inturn, merged into Chiron Berhing GmbH & Co KG.  Post-merger, Chiron Srl holds an 18% partnershipinterest, and Chiron Vaccines Holding Srl holds an 18.2% interest.

 

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