Exhibit 4.1


	NUMBER	UNITS




U-

SEE REVERSE FOR CERTAIN DEFINITIONS


 


CUSIP                 


 


ARTEMIS STRATEGIC INVESTMENT CORPORATION




UNITS CONSISTING OF ONE SHARE OF COMMON STOCK AND ONE-THIRD OF ONE 

REDEEMABLE WARRANT, EACH WHOLE WARRANT ENTITLING THE HOLDER TO 

PURCHASE ONE SHARE OF COMMON STOCK


 


THIS CERTIFIES THAT            
is the owner of             Units.


 


Each Unit (“Unit”)
consists of one (1) share of Class A common stock, par value $0.0001 per share (“Common Stock”), of Artemis
Strategic Investment Corporation, a Delaware corporation (the “Company”), and one-third of one redeemable
warrant (the “Warrant”). Each whole Warrant entitles the holder to purchase one share of Common Stock
for $11.50 per share (subject to adjustment). Each Warrant will become exercisable thirty (30) days after the Company’s completion
of a merger, capital stock exchange, asset acquisition, stock purchase, reorganization or other similar business combination with
one or more businesses (each a “Business Combination”) and will expire unless exercised before 5:00 p.m.,
New York City Time, on the date that is five (5) years after the date on which the Company completes its initial Business Combination,
or earlier upon redemption or liquidation (the “Expiration Date”). The Common Stock and Warrants comprising
the Units represented by this certificate are not transferable separately prior to               , 2021, unless Barclays Capital Inc. and
BMO Capital Markets Corp. elect to allow separate trading earlier, subject to the Company’s filing of a Current Report on
Form 8-K with the Securities and Exchange Commission containing an audited balance sheet reflecting the Company’s receipt
of the gross proceeds of the Company’s initial public offering and issuing a press release announcing when separate trading
will begin. No fractional Warrants will be issued upon separation of the Units. The terms of the Warrants are governed by a Warrant
Agreement, dated as of              , 2021, between the Company and Continental Stock Transfer & Trust Company, as Warrant Agent, and
are subject to the terms and provisions contained therein, all of which terms and provisions the holder of this certificate consents
to by acceptance hereof. Copies of the Warrant Agreement are on file at the office of the Warrant Agent at 1 State Street, 30th
Floor, New York, New York 10004, and are available to any Warrant holder on written request and without cost.


 


This certificate is
not valid unless countersigned by the Transfer Agent and registered by the Registrar of the Company. This certificate shall be
governed by and construed in accordance with the internal laws of the State of New York. Witness the facsimile signature of a duly
authorized signatory of the Company.


 


	 	 	 
	 	 	 
	 	 	 
	Authorized Signatory	 	Transfer Agent






 






     


     


    

 


ARTEMIS STRATEGIC INVESTMENT CORPORATION


 


The Company will furnish
without charge to each unitholder who so requests, a statement of the powers, designations, preferences and relative, participating,
optional or other special rights of each class of equity or series thereof of the Company and the qualifications, limitations,
or restrictions of such preferences and/or rights.


 


The following abbreviations,
when used in the inscription on the face of this certificate, shall be construed as though they were written out in full according
to applicable laws or regulations:


 


			 
	TEN
    COM — as tenants in common	UNIF
    GIFT MIN ACT	 	Custodian	 



 


	 	 	(Cust)	(Minor)
	TEN ENT — as tenants by the entireties	 	under Uniform Gifts to Minors Act
	JT
    TEN — as joint tenants with right of survivorship and not as tenants in common	 	 
	 	 	
        (State)



 


Additional abbreviations may also
be used though not in the above list.


 


For value received,          hereby sell,
assign and transfer unto


 


(PLEASE INSERT SOCIAL SECURITY OR OTHER
IDENTIFYING NUMBER OF ASSIGNEE)

(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)


 


Units represented
by the within Certificate, and do hereby irrevocably constitute and appoint


 


Attorney to transfer
the said Units on the books of the within named Company with full power of substitution in the premises.


 


	Dated	 
	 	Notice: The signature(s) to this assignment must correspond with the name as written upon the face of the certificate in every particular, without alteration or enlargement or any change whatever. 






 






     


     


    

 


	


        Signature(s)
        Guaranteed:

         

	 
	THE SIGNATURE(S) MUST BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM, PURSUANT TO S.E.C. RULE 17Ad-15 UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED (OR ANY SUCCESSOR RULE)).	 


 


As more fully described in, and subject
to the terms and conditions described in, the Company’s final prospectus for its initial public offering dated                 , 2021,
the holder(s) of this certificate shall be entitled to receive a pro-rata portion of certain funds held in the trust account established
in connection with the Company’s initial public offering only in the event that (i) the Company redeems the shares of Class
A common stock sold in the Company’s initial public offering and liquidates because it does not consummate an initial business
combination by the date set forth (the “Last Date”) in the Company’s Second Amended and Restated Certificate
of Incorporation, as the same may be amended from time to time (the “Charter”), (ii) the Company redeems the shares
of Class A common stock sold in its initial public offering properly submitted in connection with a stockholder vote to amend the
Charter to modify the substance or timing of the Company’s obligation to redeem 100% of the Class A common stock if it does
not consummate an initial business combination by the Last Date or to provide for redemption in connection with a business combination,
or (iii) if the holder(s) seek(s) to redeem for cash his, her or its respective shares of Class A common stock in connection with
a tender offer (or proxy solicitation, solely in the event the Company seeks stockholder approval of the proposed initial business
combination) setting forth the details of a proposed initial business combination. In no other circumstances shall the holder(s)
have any right or interest of any kind in or to the trust account.