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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF 

CHEMICAL SAFETY AND

POLLUTION PREVENTION

MEMORANDUM

DATE: 26-MAR-2013

SUBJECT: Spirotetramat: Acute and Chronic Dietary (Food and Drinking Water) Exposure 

and Risk Assessment to Support the Section 3 Registration Request For Use of 

Spirotetramat on Taro, Leaves; Watercress; Pomegranate; Banana; Vegetable, 

Bulb, Group 3-07; Low growing Berry Subgroup 13-07H, Except Strawberry and 

Lowbush Blueberry; Bushberry Subgroup 13-07B; Artichoke, Globe; Vegetable, 

Fruiting, Group 8-10; Fruit, Pome, Group 11-10; Fruit, Citrus, Group 10-10; 

Pineapple; and Coffee; and Tolerances without U.S. Registration in/on Corn, 

Sweet, Kernel Plus Cob with Husks Removed as Part of the U.S.-Canada 

Regulatory Cooperation Council (RCC) Pilot Project.

FROM: Julie L. Van Alstine, MPH, Environmental Health Scientist

Risk Assessment Branch 1 (RAB1)/Health Effects Division (HED; 7509P)

THROUGH: Douglas A. Dotson, Ph.D., Chemist

Kristin Rury, Biologist 

Dietary Exposure Science Advisory Council (DESAC)

HED (7509P)

and

George F. Kramer, Ph.D., Branch Senior Chemist

RAB1/HED (7509P)

TO: Barbara Madden/Laura Nollen, RM 05

Registration Division (RD; 7505P)

Executive Summary

Acute and chronic dietary-exposure and risk assessments were conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) 

PC Code: 392201 DP No.: D398858

Decision No.: 459092 Registration No.: 264-1050

Petition No.: 1E7958 Regulatory Action: Section 3

Risk Assessment Type: Dietary Case No.: 7452

TXR No.: NA CAS No.: 203313-25-1

MRID No.: NA 40 CFR: §180.641
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

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Version 3.16, which uses food consumption data from the U.S. Department of Agriculture’s 

National Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES/WWEIA) from 2003 through 2008. The analyses were performed to support a 

proposed Section 3 registration request by Interregional Research Project Number 4 (IR-4) for

the application of the active ingredient spirotetramat (cis-3-(2,5-dimethylphenyl)-8-methoxy-2-

oxo-1-azaspiro[4.5]dec-3-en-4-yl ethyl carbonate) to taro, watercress, pomegranates, bananas, 

bulb vegetables, low-growing berries (except strawberries), bushberries, globe artichokes, 

fruiting vegetables, pome fruit, citrus fruit, pineapples, and coffee and, as part of the U.S.-

Canada Regulatory Cooperation Council (RCC) pilot project1, the establishment of a tolerance 

without U.S. registration for residues of spirotetramat in/on corn, sweet, kernel plus cob with 

husks removed. These analyses have been reviewed by two peer reviewers of the DESAC, per 

the DESAC Standard Operating Procedure (SOP) 2012.1. 

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization 

The acute analysis assumed 100% crop treated (CT), tolerance-level residues for all foods, and 

DEEM 7.81 default processing factors (where provided). Dietary risk estimates were determined 

considering exposures from food plus drinking water using estimated drinking water 

concentrations (EDWCs) for surface water sources provided by the Environmental Fate and 

Effects Division (EFED). EDWC values were generated using the watercress use pattern and the 

Tier 1 Rice Model v.1.0 since the proposed Section 3 use on watercress yielded the highest acute 

EDWC values. The acute dietary risk assessment shows that for all included commodities, the 

acute dietary risk estimates at the 95th percentile are not of concern to HED [i.e., <100% acute 

population-adjusted dose (aPAD)]. The resulting acute dietary (food + water) risk estimates 

utilized 7% of the aPAD for the general U.S. population and 16% of the aPAD for children 1-2 

years old, the most highly exposed population subgroup. 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

The chronic dietary assessment assumed 100% CT, average field trial residues for some 

commodities, and tolerance-level residues for the remaining commodities. Some empirical 

processing factors were used along with DEEM 7.81 default processing factors (where 

provided). EDWC values were generated using the watercress use pattern and the Tier 1 Rice 

Model v.1.0 since the proposed Section 3 use on watercress yielded the highest chronic EDWC 

values. The chronic dietary risk assessment shows that for all included commodities, the chronic 

dietary risk estimates are not of concern to HED [i.e., <100% chronic population-adjusted dose 

(cPAD)]. The resulting chronic dietary (food + water) risk estimates utilized 36% of the cPAD 

for the general U.S. population and 76% of the cPAD for children 1-2 years old, the most highly

exposed population subgroup. 

Cancer 

Spirotetramat was classified as “not likely to be carcinogenic to humans”; therefore, a cancer 

dietary assessment was not performed. 

 

1

For more information about the RCC pilot project, please refer to 

http://www.epa.gov/oppfead1/international/naftatwg/us-canada-rcc.html. 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

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I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG1999).

The most recent dietary risk assessment for spirotetramat was conducted on 01-AUG-2012 

(Memo, J. Van Alstine; D404051).

II. Residue Information

Residues of Concern: The nature of the residue in plants, rotational crops, and livestock is 

adequately understood based on acceptable metabolism studies conducted on apple, lettuce, 

cotton, potato, rotational crops, lactating goats, and laying hens. The residues of concern for the 

tolerance expression and risk assessment for plant commodities are spirotetramat and its 

metabolites BYI 08330-enol, BYI 08330-ketohydroxy, BYI08330-enol-Glc, and BYI 08330-

mono-hydroxy. Based on the currently proposed uses, the residues of concern for the tolerance 

expression for livestock commodities are spirotetramat and its metabolite BYI 08330-enol, and 

the residues of concern for the risk assessment for livestock commodities are spirotetramat and 

its metabolites BYI 08330-enol and BYI 08330-enol-GA (Memo, J. Tyler et al., 4/16/08; 

D333437). 

Established Tolerances: Permanent tolerances for the combined residues of spirotetramat and its 

metabolites BYI 08330-enol, BYI 08330-ketohydroxy, BYI08330-enol-Glc, and BYI 08330-

mono-hydroxy, calculated as spirotetramat equivalents, are currently established in/on a wide 

variety of crops (40 CFR §180.641). 

Recommended Tolerances: Based on the residue chemistry data submitted with the current 

petition, HED recommended for establishment of the tolerances outlined in Table 1 for the 

combined residues of spirotetramat and its metabolites BYI 08330-enol, BYI 08330-

ketohydroxy, BYI08330-enol-Glc, and BYI 08330-mono-hydroxy, calculated as the 

stoichiometric equivalent of spirotetramat.

Table 1. Tolerance Summary for Spirotetramat.

Commodity Recommended Tolerance (ppm)

Taro, leaves 9.0

Watercress 2.0

Pomegranate 0.50

Banana14.0
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

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Table 1. Tolerance Summary for Spirotetramat.

Commodity Recommended Tolerance (ppm)

Vegetable, bulb, group 3-07 0.80

Low growing berry subgroup 13-07H, 

except strawberry and lowbush blueberry 0.30

Bushberry subgroup 13-07B 3.0

Artichoke, globe 1.5

Vegetable, fruiting, group 8-10 2.5

Fruit, pome, group 11-10 0.70

Fruit, citrus, group 10-10 0.60

Pineapple 0.30

Coffee, green bean 0.20

Coffee, instant 0.50

Corn, sweet, kernel plus cob with husks 

removed2 1.5

1

 This tolerance should be established under 40 CFR §180.641(c) Tolerances with regional registrations.

2

 There are no U.S. registrations as of [date] for use on corn, sweet.

 

Residue Data Used for Acute and Chronic Assessments: The acute assessment assumed 

tolerance-level residues. The chronic assessment incorporated average field trial residues for 

some commodities (see Attachment 3) and tolerance-level residues for the remaining 

commodities. Additionally, the potato average field trial residue was translated to sweet potatoes 

using HED SOP 2000.1. The residue levels for livestock commodities were not adjusted for the 

additional metabolite of concern for the risk assessment (BYI 08330-enol-GA) as the tolerancelevel values are sufficient to cover the total residues of spirotetramat, BYI 08330-enol, and BYI 

08330-enol-GA (G. Kramer, 09-APR-2010; D362952). The tolerances in 40 CFR §180.641 for 

residues in/on feijoa, papaya, and Spanish lime do not match the recommended tolerances from 

the previous assessment (Memo, J. Van Alstine et al., 22-DEC-2010; D368785). For feijoa and 

Spanish lime, the HED-recommended tolerances were higher than the tolerance in the 40 CFR; 

therefore, the recommended tolerances of 2.5 ppm and 13 ppm, respectively, were used in this 

assessment. For papaya, the HED-recommended tolerance of 0.35 ppm is lower than the 

tolerance in the 40 CFR; therefore, the higher tolerance of 2.5 ppm from the 40 CFR was used in 

this assessment as a conservative assumption. Additionally, HED recommended a tolerance of 

2.5 ppm for residues in/on persimmon, which was excluded from the 40 CFR. This tolerance has 

been included in the assessment. Finally, the recommended tolerance of 0.80 ppm for the bulb 

vegetable subgroup 3-07 was used for the entire crop group because this tolerance will replace 

the currently established tolerance of 0.30 ppm for bulb onion subgroup 3A-07. 

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, 

and 2010; however, the samples were not analyzed for spirotetramat. As a result, residues in fish 

were not included in the assessment.

Processing Factors: For the acute assessment, DEEM 7.81 default processing factors were used 

(where provided). For the chronic assessment, empirical processing factors were used for the 

following processed commodities: apple, orange, grape, tomato, and pineapple juice; 

applesauce; and dried apple and tomato. The processing factors have been set to 1 for dried 

plums and tomato paste and puree because separate tolerances were not required for these 

commodities based on the available processing data and since tolerance-level residues were used 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

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in the assessment. DEEM 7.81 default processing factors were used for the remaining processed 

commodities (where provided). (See Attachment 3.)

III. Percent Crop Treated

Both the acute and chronic assessments assumed 100% CT for all commodities. 

IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by EFED (Memo, 

J. Meléndez, 19-JUL-2012; D398507). The drinking water models and their descriptions are 

available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/.

Exposure to spirotetramat in surface water is possible through surface water runoff, soil erosion, 

and/or off-target spray drift. The mobility of spirotetramat is relatively high [Kd range 3.58-5.52 

mL/g, KOC range 184-437 mL/gOC (moderately mobile)] and it is labile under many conditions, 

especially under aerobic soil metabolism conditions. Nonetheless, its total residues are relatively 

persistent. The Tier I EDWCs for spirotetramat and for its major transformation products, 

spirotetramat-enol and spirotetramat-ketohydroxy, were calculated using SCI-GROW v.2.3 

(groundwater, applications to bananas and plantains) and the Tier 1 Rice Model v.1.0 (surface 

water, as a surrogate for applications to watercress). The Tier 1 Rice Model v.1.0 resulted in the 

highest EDWC for use in the acute and chronic assessments. Therefore, the surface water 

EDWC value of 0.395 ppm was incorporated in DEEM-FCID into the food categories “water, 

direct, all sources” and “water, indirect, all sources” for both the acute and chronic assessments. 

Watercress is typically grown in clean, flowing water, 2 to 3 inches deep.2 Based on the 

previous review and information provided by the registrant and IR-4, it appears that watercress is 

grown in a bed of water that drains to a ditch and is constantly recirculated. The circulation of 

water is stopped 24 hours before chemical application and is turned back on 24 hours after 

application. The Agency does not currently have a methodology for exposure assessment for 

crops cultivated in flowing water, such as watercress. The EFED Tier 1 Rice model v.1.0 has, 

therefore, been used as the basis of the assessment, and the results have been characterized to 

reflect differences between the capabilities of this model and the watercress cultivation practices. 

EFED is concerned primarily about the total toxic residues (TTR), as opposed to individual 

metabolites (spirotetramat, spirotetramat-enol, and spirotetramat-ketohydroxy), from discharge 

towards adjacent bodies of water at the end of the season. Individual metabolites were not 

modeled because this would double count the mass of pesticide and the transformation products 

in this particular model. Rice cultivation differs from watercress cultivation in that for the latter, 

the water is constantly flowing, while for rice, the field is flooded. The Tier 1 Rice Model v.1.0 

provides a conservative, screening-level estimate. Crop interception, pesticide degradation, 

stream flow, and runoff dilution from the areas in the watershed which are not treated all have 

the potential to reduce the conservative EDWCs generated by the Tier 1 Rice Model. 

 

2

http://www.naturesherbal.com/Watercress.htm, and see also http://www.bwqualitygrowers.com/ourfarms.aspx

accessed 03/27/2012.
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

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Table 2. Maximum Tier I EDWCs for Drinking Water Risk Assessment Based on Ground or Aerial 

Application of Spirotetramat on Plantains and Bananas (for Groundwater) at 1.25 lb a.i./A/Season, 

and Ground, Aerial, or Chemigation Applications on Watercress (for Surface Water) at 0.4 lb 

a.i./A/Season.

Drinking 

Water Source 

(MODEL)

EDWC

Chemical: Parent

Spirotetramat

SpirotetramatenolSpirotetramatketohydroxyTotal Toxic 

Residues (TTR)1

Risk \ Units (ppb) (ppb) (ppb) (ppb)

Ground-water 

(SCI-GROW)

Acute & 

Chronic2 7.06 x 10-5

5.15 x 10-51.12 x 10-31.24 x 10-3

Surface Water 

(Tier 1 Rice 

Model v.1.0)

Acute & 

Chronic2 N/A N/A N/A 395

1 TTR = Total Toxic Residues (sum of spirotetramat + spirotetramat-enol + spirotetramat-ketohydroxy).

2

Surface-water concentrations calculated by the Tier I Rice Model v1.0 and ground water concentrations calculated 

by SCI-GROW do not distinguish between peak and chronic concentrations.

V. DEEM-FCID Program and Consumption Information

Spirotetramat acute and chronic dietary exposure assessments were conducted using DEEMFCID, Version 3.16, which incorporates consumption data from USDA’s NHANES/WWEIA 

from 2003 through 2008. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

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commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.

VI. Toxicological Information

Table 3 summarizes the toxicological doses and endpoints for spirotetramat concerning dietary

exposure assessment. The endpoints have been reviewed by the risk assessment team and are 

considered appropriate for the current risk assessment. 

Table 3. Summary of Toxicological Doses and Endpoints for Spirotetramat for Use in Dietary Human-Health 

Risk Assessments. 

Exposure Scenario Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, LOC for 

Risk Assessment

Study and Relevant 

Toxicological Effects

Acute Dietary (General 

Population, including 

Infants and Children)

NOAEL = 

100

mg/kg/day

UFA = 10X

UFH = 10X

UFFQPA = 1X 

aRfD = aPAD = 1.0 

mg/kg/day

Acute neurotoxicity (rat; oral 

gavage)

LOAEL = 200 mg/kg based on 

clinical signs (M&F) and 

decreased motor activity (M).

Chronic Dietary (All 

Populations)

NOAEL = 5

mg/kg/day

UFA = 10X

UFH = 10X

UFFQPA = 1X

cRfD = cPAD = 0.05 

mg/kg/day1

Chronic toxicity (dog; dietary)

LOAEL = 20 mg/kg/day (M) 

based on thymus involution.

Cancer (Oral, Dermal, 

Inhalation)

Classification: “not likely to be carcinogenic to humans” based on lack of evidence of 

carcinogenicity in two oral rodent carcinogenicity studies.

Abbreviations: UF = uncertainty factor, UFA = extrapolation from animal to human (interspecies), UFH = potential variation in sensitivity among 

members of the human population (intraspecies), UFFQPA = FQPA Safety Factor, NOAEL = no-observed adverse-effect level, LOAEL = lowestobserved adverse-effect level, RfD = reference dose (a = acute, c = chronic), PAD = population-adjusted dose, LOC = level of concern.

1 The cRfD has been harmonized across American (USEPA), Canadian (PMRA), and Austrian (AGES) regulatory agencies. However, it is noted 

that USEPA considered a NOAEL = 6 mg/kg/day in males and a NOAEL = 19 mg/kg/day in females to more accurately reflect the toxicological 

data. The difference between 5 mg/kg/day (NOAEL in females for PMRA and AGES) and 6 mg/kg/day was considered negligible for risk 

assessment.

VII. Results/Discussion 

For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the 

PAD. The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and 

various population subgroups. The results reported in Table 4 are for the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50-99 years. 

Results of Acute and Chronic Dietary Exposure Analyses

The acute dietary exposure for food and drinking water utilized 7% of the aPAD for the U.S. 

population. The acute dietary exposure estimate for the highest reported exposed population 

subgroup, children 1-2 years old, utilized 16% of the aPAD. The chronic dietary exposure 

estimate for food and drinking water utilized 36% of the cPAD for the U.S. population. The 

chronic dietary exposure for the highest reported exposed population subgroup, children 1-2 

years old, utilized 76% of the cPAD. Spirotetramat was classified as “not likely to be 

carcinogenic to humans”; therefore, a cancer dietary assessment was not performed. The results 

of the acute and chronic dietary exposure analyses are reported in Table 4. 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

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Table 4. Summary of Dietary (Food and Drinking Water) Exposure Risk for Spirotetramat1.

Population Subgroup

Acute Dietary (95th Percentile) Chronic Dietary

Dietary Exposure 

(mg/kg/day) % aPAD Dietary Exposure(mg/kg/day) % cPAD

General U.S. Population 0.066115 7 0.017785 36

All Infants (<1 year old) 0.137642 14 0.036886 74

Children 1-2 years old 0.155241 16 0.038038 76

Children 3-5 years old 0.125606 13 0.030925 62

Children 6-12 years old 0.075624 8 0.019418 39

Youth 13-19 years old 0.046354 5 0.013149 26

Adults 20-49 years old 0.053000 5 0.016159 32

Adults 50-99 years old 0.050326 5 0.016494 33

Females 13-49 years old 0.052999 5 0.015902 32

1 The values for the highest exposed population for each type of risk assessment are bolded.

Further refinement to the analyses could be made through the use of additional average field trial 

values and translation of average field trial residues to other commodities using HED SOP 

2000.1, additional empirical processing factors, incorporation of percentages of crops treated 

with spirotetramat, or monitoring data. Since risk estimates are below HED’s level of concern, a 

more highly refined analysis is not required at this time.

VIII. Conclusions

Acute and chronic dietary exposure and risk assessments were conducted for the proposed food 

uses and permanent tolerances of spirotetramat, including potential exposure from drinking 

water. The acute and chronic dietary (food + drinking water) exposure and risk estimates for 

spirotetramat are below HED’s level of concern for the general U.S. population and all 

population subgroups. The most highly exposed population subgroup for both the acute and 

chronic assessments was children 1-2 years old. This population subgroup utilized 16% of the 

aPAD and 76% of the cPAD.

IX. List of Attachments

Attachment 1: Acute Food plus Water Residue Input File

Attachment 2: Acute Results File

Attachment 3: Average Field Trial Residues and Processing Factors Used in the Chronic 

Assessment

Attachment 4: Chronic Food plus Water Residue Input File

Attachment 5: Chronic Results File

RDI: DE SAC Reviewers: 11-26-2012; G. Kramer: 11-26-2012

DP No.: D398858

Petition No.: 1E7958

PC Code: 392201

J. L.Van Alstine:S-10951:PY-S:(703)603-8866:7509P:RAB1
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 9 of 25

Attachment 1: Acute and Chronic Food plus Water Residue Input File

Filename: C:\Documents and Settings\jlangsda\My Documents\Chemicals\Spirotetramat\2012 

RCC\Dietary\Sent to Reviewers\updated to include Kiwi\updated SPIROTETRAMAT__ACUTE__21 Dec 

2012.R08

Chemical: Spirotetramat

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 12-21-2012/11:35:33 Program ver. 3.16, 03-08-d

Comment: + emp proc fact

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0103015000 1CD Arrowroot, flour 0.600000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.600000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.600000 1.000 1.000 

0103082000 1CD Cassava 0.600000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.600000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.600000 1.000 1.000 

0103166000 1CD Ginger 0.600000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.600000 1.000 1.000 

0103167000 1CD Ginger, dried 0.600000 1.000 1.000 

0103296000 1C Potato, chips 0.600000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 1.600000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 1.600000 1.000 1.000 

0103298000 1C Potato, flour 1.600000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 1.600000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.600000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.600000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.600000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.600000 1.000 1.000 

0103366000 1CD Sweet potato 0.600000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.600000 1.000 1.000 

0103371000 1CD Tanier, corm 0.600000 1.000 1.000 

0103387000 1CD Turmeric 0.600000 1.000 1.000 

0103406000 1CD Yam, true 0.600000 1.000 1.000 

0103407000 1CD Yam bean 0.600000 1.000 1.000 

0301165000 3A Garlic, bulb 0.800000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.800000 1.000 1.000 

0301237000 3A Onion, bulb 0.800000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.800000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.800000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.800000 9.000 1.000 

0301338000 3A Shallot, bulb 0.800000 1.000 1.000 

0302103000 3B Chive, fresh leaves 0.800000 1.000 1.000 

0302198000 3B Leek 0.800000 1.000 1.000 

0302239000 3B Onion, green 0.800000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 0.800000 1.000 1.000 

0401005000 4A Amaranth, leafy 9.000000 1.000 1.000 

0401018000 4A Arugula 9.000000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 9.000000 1.000 1.000 

0401133000 4A Cress, garden 9.000000 1.000 1.000 

0401134000 4A Cress, upland 9.000000 1.000 1.000 

0401138000 4A Dandelion, leaves 9.000000 1.000 1.000 

0401150000 4A Endive 9.000000 1.000 1.000 

0401204000 4A Lettuce, head 9.000000 1.000 1.000 

0401205000 4A Lettuce, leaf 9.000000 1.000 1.000 

0401248000 4A Parsley, leaves 9.000000 1.000 1.000 

0401313000 4A Radicchio 9.000000 1.000 1.000 

0401355000 4A Spinach 9.000000 1.000 1.000 

0401355001 4A Spinach-babyfood 9.000000 1.000 1.000 

0402076000 4B Cardoon 9.000000 1.000 1.000 

0402085000 4B Celery 9.000000 1.000 1.000 

0402085001 4B Celery-babyfood 9.000000 1.000 1.000 

0402086000 4B Celery, juice 9.000000 1.000 1.000 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 10 of 25

0402087000 4B Celtuce 9.000000 1.000 1.000 

0402152000 4B Fennel, Florence 9.000000 1.000 1.000 

0402322000 4B Rhubarb 9.000000 1.000 1.000 

0402367000 4B Swiss chard 9.000000 1.000 1.000 

0501061000 5A Broccoli 2.500000 1.000 1.000 

0501061001 5A Broccoli-babyfood 2.500000 1.000 1.000 

0501062000 5A Broccoli, Chinese 2.500000 1.000 1.000 

0501064000 5A Brussels sprouts 2.500000 1.000 1.000 

0501069000 5A Cabbage 2.500000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 2.500000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 2.500000 1.000 1.000 

0501083000 5A Cauliflower 2.500000 1.000 1.000 

0501196000 5A Kohlrabi 2.500000 1.000 1.000 

0502063000 5B Broccoli raab 8.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 8.000000 1.000 1.000 

0502117000 5B Collards 8.000000 1.000 1.000 

0502194000 5B Kale 8.000000 1.000 1.000 

0502229000 5B Mustard greens 8.000000 1.000 1.000 

0502318000 5B Rape greens 8.000000 1.000 1.000 

0502389000 5B Turnip, greens 8.000000 1.000 1.000 

0600347000 6 Soybean, seed 5.000000 1.000 1.000 

0600349000 6 Soybean, soy milk 5.000000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 5.000000 1.000 1.000 

0600350000 6 Soybean, oil 5.000000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 5.000000 1.000 1.000 

0601043000 6A Bean, snap, succulent 2.500000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 2.500000 1.000 1.000 

0601257000 6A Pea, edible podded, succulent 2.500000 1.000 1.000 

0601349500 6AB Soybean, vegetable 5.000000 1.000 1.000 

0602031000 6B Bean, broad, succulent 2.500000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 2.500000 1.000 1.000 

0602037000 6B Bean, lima, succulent 2.500000 1.000 1.000 

0602255000 6B Pea, succulent 2.500000 1.000 1.000 

0602255001 6B Pea, succulent-babyfood 2.500000 1.000 1.000 

0602259000 6B Pea, pigeon, succulent 2.500000 1.000 1.000 

0603030000 6C Bean, black, seed 2.500000 1.000 1.000 

0603032000 6C Bean, broad, seed 2.500000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 2.500000 1.000 1.000 

0603035000 6C Bean, great northern, seed 2.500000 1.000 1.000 

0603036000 6C Bean, kidney, seed 2.500000 1.000 1.000 

0603038000 6C Bean, lima, seed 2.500000 1.000 1.000 

0603039000 6C Bean, mung, seed 2.500000 1.000 1.000 

0603040000 6C Bean, navy, seed 2.500000 1.000 1.000 

0603041000 6C Bean, pink, seed 2.500000 1.000 1.000 

0603042000 6C Bean, pinto, seed 2.500000 1.000 1.000 

0603098000 6C Chickpea, seed 2.500000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 2.500000 1.000 1.000 

0603099000 6C Chickpea, flour 2.500000 1.000 1.000 

0603182000 6C Guar, seed 2.500000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 2.500000 1.000 1.000 

0603203000 6C Lentil, seed 2.500000 1.000 1.000 

0603256000 6C Pea, dry 2.500000 1.000 1.000 

0603256001 6C Pea, dry-babyfood 2.500000 1.000 1.000 

0603258000 6C Pea, pigeon, seed 2.500000 1.000 1.000 

0603348000 6C Soybean, flour 5.000000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 5.000000 1.000 1.000 

0801374000 8A Tomatillo 2.500000 1.000 1.000 

0801375000 8A Tomato 2.500000 1.000 1.000 

0801375001 8A Tomato-babyfood 2.500000 1.000 1.000 

0801376000 8A Tomato, paste 2.500000 5.400 1.000 

0801376001 8A Tomato, paste-babyfood 2.500000 5.400 1.000 

0801377000 8A Tomato, puree 2.500000 3.300 1.000 

0801377001 8A Tomato, puree-babyfood 2.500000 3.300 1.000 

0801378000 8A Tomato, dried 2.500000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 2.500000 14.300 1.000 

0801379000 8A Tomato, juice 2.500000 1.500 1.000 

0801380000 8A Tomato, Tree 2.500000 1.000 1.000 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 11 of 25

0802148000 8BC Eggplant 2.500000 1.000 1.000 

0802234000 8BC Okra 2.500000 1.000 1.000 

0802270000 8B Pepper, bell 2.500000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 2.500000 1.000 1.000 

0802271000 8B Pepper, bell, dried 2.500000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 2.500000 1.000 1.000 

0802272000 8BC Pepper, nonbell 2.500000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 2.500000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 2.500000 1.000 1.000 

0901075000 9A Cantaloupe 0.300000 1.000 1.000 

0901187000 9A Honeydew melon 0.300000 1.000 1.000 

0901399000 9A Watermelon 0.300000 1.000 1.000 

0901400000 9A Watermelon, juice 0.300000 1.000 1.000 

0902021000 9B Balsam pear 0.300000 1.000 1.000 

0902088000 9B Chayote, fruit 0.300000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.300000 1.000 1.000 

0902135000 9B Cucumber 0.300000 1.000 1.000 

0902308000 9B Pumpkin 0.300000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.300000 1.000 1.000 

0902356000 9B Squash, summer 0.300000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.300000 1.000 1.000 

0902357000 9B Squash, winter 0.300000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.300000 1.000 1.000 

1001106000 10A Citron 0.600000 1.000 1.000 

1001107000 10A Citrus hybrids 0.600000 1.000 1.000 

1001108000 10A Citrus, oil 6.000000 1.000 1.000 

1001240000 10A Orange 0.600000 1.000 1.000 

1001241000 10A Orange, juice 0.600000 1.800 1.000 

1001241001 10A Orange, juice-babyfood 0.600000 1.800 1.000 

1001242000 10A Orange, peel 0.600000 1.000 1.000 

1001369000 10A Tangerine 0.600000 1.000 1.000 

1001370000 10A Tangerine, juice 0.600000 2.300 1.000 

1002197000 10B Kumquat 0.600000 1.000 1.000 

1002199000 10B Lemon 0.600000 1.000 1.000 

1002200000 10B Lemon, juice 0.600000 2.000 1.000 

1002200001 10B Lemon, juice-babyfood 0.600000 2.000 1.000 

1002201000 10B Lemon, peel 0.600000 1.000 1.000 

1002206000 10B Lime 0.600000 1.000 1.000 

1002207000 10B Lime, juice 0.600000 2.000 1.000 

1002207001 10B Lime, juice-babyfood 0.600000 2.000 1.000 

1003180000 10C Grapefruit 0.600000 1.000 1.000 

1003181000 10C Grapefruit, juice 0.600000 2.100 1.000 

1003307000 10C Pummelo 0.600000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.700000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.700000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.700000 1.000 1.000 

1100009000 11 Apple, dried 0.700000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.700000 8.000 1.000 

1100010000 11 Apple, juice 0.700000 1.300 1.000 

1100010001 11 Apple, juice-babyfood 0.700000 1.300 1.000 

1100011000 11 Apple, sauce 0.700000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.700000 1.000 1.000 

1100129000 11 Crabapple 0.700000 1.000 1.000 

1100173500 11 Goji berry 2.500000 1.000 1.000 

1100210000 11 Loquat 0.700000 1.000 1.000 

1100266000 11 Pear 0.700000 1.000 1.000 

1100266001 11 Pear-babyfood 0.700000 1.000 1.000 

1100267000 11 Pear, dried 0.700000 6.250 1.000 

1100268000 11 Pear, juice 0.700000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.700000 1.000 1.000 

1100310000 11 Quince 0.700000 1.000 1.000 

1201090000 12A Cherry 4.500000 1.000 1.000 

1201090001 12A Cherry-babyfood 4.500000 1.000 1.000 

1201091000 12A Cherry, juice 4.500000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 4.500000 1.500 1.000 

1202012000 12B Apricot 4.500000 1.000 1.000 

1202012001 12B Apricot-babyfood 4.500000 1.000 1.000 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 12 of 25

1202013000 12B Apricot, dried 4.500000 6.000 1.000 

1202014000 12B Apricot, juice 4.500000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 4.500000 1.000 1.000 

1202230000 12B Nectarine 4.500000 1.000 1.000 

1202260000 12B Peach 4.500000 1.000 1.000 

1202260001 12B Peach-babyfood 4.500000 1.000 1.000 

1202261000 12B Peach, dried 4.500000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 4.500000 7.000 1.000 

1202262000 12B Peach, juice 4.500000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 4.500000 1.000 1.000 

1203285000 12C Plum 4.500000 1.000 1.000 

1203285001 12C Plum-babyfood 4.500000 1.000 1.000 

1203286000 12C Plum, prune, fresh 4.500000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 4.500000 1.000 1.000 

1203287000 12C Plum, prune, dried 4.500000 5.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 4.500000 5.000 1.000 

1203288000 12C Plum, prune, juice 4.500000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 4.500000 1.400 1.000 

1302057000 13B Blueberry 3.000000 1.000 1.000 

1302057001 13B Blueberry-babyfood 3.000000 1.000 1.000 

1302136000 13B Currant 3.000000 1.000 1.000 

1302137000 13B Currant, dried 3.000000 1.000 1.000 

1302149000 13B Elderberry 3.000000 1.000 1.000 

1302174000 13B Gooseberry 3.000000 1.000 1.000 

1302191000 13B Huckleberry 3.000000 1.000 1.000 

1304175000 13D Grape 1.300000 1.000 1.000 

1304176000 13D Grape, juice 1.300000 1.200 1.000 

1304176001 13D Grape, juice-babyfood 1.300000 1.200 1.000 

1304179000 13D Grape, wine and sherry 1.300000 1.000 1.000 

1304195000 13D Kiwifruit, fuzzy 1.300000 1.000 1.000 

1307130000 13G Cranberry 0.300000 1.000 1.000 

1307130001 13G Cranberry-babyfood 0.300000 1.000 1.000 

1307131000 13G Cranberry, dried 0.300000 1.000 1.000 

1307132000 13G Cranberry, juice 0.300000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 0.300000 1.100 1.000 

1307359000 13G Strawberry 0.400000 1.000 1.000 

1307359001 13G Strawberry-babyfood 0.400000 1.000 1.000 

1307360000 13G Strawberry, juice 0.400000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 0.400000 1.000 1.000 

1400003000 14 Almond 0.250000 1.000 1.000 

1400003001 14 Almond-babyfood 0.250000 1.000 1.000 

1400004000 14 Almond, oil 0.250000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.250000 1.000 1.000 

1400059000 14 Brazil nut 0.250000 1.000 1.000 

1400068000 14 Butternut 0.250000 1.000 1.000 

1400081000 14 Cashew 0.250000 1.000 1.000 

1400092000 14 Chestnut 0.250000 1.000 1.000 

1400155000 14 Hazelnut 0.250000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.250000 1.000 1.000 

1400185000 14 Hickory nut 0.250000 1.000 1.000 

1400213000 14 Macadamia nut 0.250000 1.000 1.000 

1400269000 14 Pecan 0.250000 1.000 1.000 

1400282000 14 Pistachio 0.250000 1.000 1.000 

1400391000 14 Walnut 0.250000 1.000 1.000 

1500127000 15 Corn, sweet 1.500000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 1.500000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.300000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.300000 1.000 1.000 

3100044000 31 Beef, meat 0.020000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.020000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.020000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.200000 1.000 1.000 

3100047000 31 Beef, fat 0.020000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.020000 1.000 1.000 

3100048000 31 Beef, kidney 0.200000 1.000 1.000 

3100049000 31 Beef, liver 0.200000 1.000 1.000 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 13 of 25

3100049001 31 Beef, liver-babyfood 0.200000 1.000 1.000 

3200169000 32 Goat, meat 0.020000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 

3200171000 32 Goat, fat 0.020000 1.000 1.000 

3200172000 32 Goat, kidney 0.200000 1.000 1.000 

3200173000 32 Goat, liver 0.200000 1.000 1.000 

3300189000 33 Horse, meat 0.020000 1.000 1.000 

3400291000 34 Pork, skin 0.020000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.020000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.020000 1.000 1.000 

3400294000 34 Pork, kidney 0.020000 1.000 1.000 

3400295000 34 Pork, liver 0.020000 1.000 1.000 

3500339000 35 Sheep, meat 0.020000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.020000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 

3500341000 35 Sheep, fat 0.020000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.020000 1.000 1.000 

3500342000 35 Sheep, kidney 0.200000 1.000 1.000 

3500343000 35 Sheep, liver 0.200000 1.000 1.000 

3600222000 36 Milk, fat 0.010000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.010000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.010000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 

3600224000 36 Milk, water 0.010000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.010000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 

3800221000 38 Meat, game 0.020000 1.000 1.000 

4000094000 40 Chicken, liver 0.020000 1.000 1.000 

4000095000 40 Chicken, meat byproducts 0.020000 1.000 1.000 

4000095001 40 Chicken, meat byproducts-babyfoo 0.020000 1.000 1.000 

4000097000 40 Chicken, skin 0.020000 1.000 1.000 

4000097001 40 Chicken, skin-babyfood 0.020000 1.000 1.000 

5000383000 50 Turkey, liver 0.020000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.020000 1.000 1.000 

5000384000 50 Turkey, meat byproducts 0.020000 1.000 1.000 

5000384001 50 Turkey, meat byproducts-babyfood 0.020000 1.000 1.000 

5000386000 50 Turkey, skin 0.020000 1.000 1.000 

5000386001 50 Turkey, skin-babyfood 0.020000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.020000 1.000 1.000 

6000303000 60 Poultry, other, meat byproducts 0.020000 1.000 1.000 

6000305000 60 Poultry, other, skin 0.020000 1.000 1.000 

7000145000 70 Egg, whole 0.020000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.020000 1.000 1.000 

7000146000 70 Egg, white 0.020000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.020000 1.000 1.000 

7000147000 70 Egg, yolk 0.020000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.020000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.395000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.395000 1.000 1.000 

9500001000 O Acerola 2.500000 1.000 1.000 

9500016000 O Artichoke, globe 1.500000 1.000 1.000 

9500020000 O Avocado 0.600000 1.000 1.000 

9500023000 O Banana 4.000000 1.000 1.000 

9500023001 O Banana-babyfood 4.000000 1.000 1.000 

9500024000 O Banana, dried 4.000000 3.900 1.000 

9500024001 O Banana, dried-babyfood 4.000000 3.900 1.000 

9500074000 O Canistel 0.600000 1.000 1.000 

9500115000 O Coffee, roasted bean 0.200000 1.000 1.000 

9500116000 O Coffee, instant 0.500000 1.000 1.000 

9500151000 O Feijoa 2.500000 1.000 1.000 

9500177000 O Grape, leaves 1.300000 1.000 1.000 

9500178000 O Grape, raisin 3.000000 1.000 1.000 

9500183000 O Guava 2.500000 1.000 1.000 

9500183001 O Guava-babyfood 2.500000 1.000 1.000 

9500188000 O Hop 10.000000 1.000 1.000 

9500209000 O Longan 13.000000 1.000 1.000 

9500211000 O Lychee 13.000000 1.000 1.000 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 14 of 25

9500212000 O Lychee, dried 13.000000 1.850 1.000 

9500215000 O Mango 0.600000 1.000 1.000 

9500215001 O Mango-babyfood 0.600000 1.000 1.000 

9500216000 O Mango, dried 0.600000 1.000 1.000 

9500217000 O Mango, juice 0.600000 1.000 1.000 

9500217001 O Mango, juice-babyfood 0.600000 1.000 1.000 

9500245000 O Papaya 2.500000 1.000 1.000 

9500245001 O Papaya-babyfood 2.500000 1.000 1.000 

9500246000 O Papaya, dried 2.500000 1.800 1.000 

9500247000 O Papaya, juice 2.500000 1.500 1.000 

9500252000 O Passionfruit 2.500000 1.000 1.000 

9500252001 O Passionfruit-babyfood 2.500000 1.000 1.000 

9500253000 O Passionfruit, juice 2.500000 1.000 1.000 

9500253001 O Passionfruit, juice-babyfood 2.500000 1.000 1.000 

9500277000 O Persimmon 2.500000 1.000 1.000 

9500279000 O Pineapple 0.300000 1.000 1.000 

9500279001 O Pineapple-babyfood 0.300000 1.000 1.000 

9500280000 O Pineapple, dried 0.300000 5.000 1.000 

9500281000 O Pineapple, juice 0.300000 1.700 1.000 

9500281001 O Pineapple, juice-babyfood 0.300000 1.700 1.000 

9500283000 O Plantain 4.000000 1.000 1.000 

9500284000 O Plantain, dried 4.000000 3.900 1.000 

9500289000 O Pomegranate 0.500000 1.000 1.000 

9500333000 O Sapote, Mamey 0.600000 1.000 1.000 

9500351000 O Spanish lime 13.000000 1.000 1.000 

9500358000 O Starfruit 2.500000 1.000 1.000 

9500398000 O Watercress 2.000000 1.000 1.000 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 15 of 25

Attachment 2: Acute Results File 

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for SPIROTETRAMAT NHANES 2003-2008 2-Day

Residue file: updated SPIROTETRAMAT__ACUTE__21 Dec 2012.R08

 Adjustment factor #2 used.

Analysis Date: 12-21-2012/13:26:05 Residue file dated: 12-21-2012/11:35:33

RAC/FF intake summed over 24 hours

Run Comment: "+ emp proc fact"

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Total US Population:

 0.066115 6.61 0.114460 11.45 0.209645 20.96 

All Infants:

 0.137642 13.76 0.220433 22.04 0.419080 41.91 

Children 1-2:

 0.155241 15.52 0.282877 28.29 0.447437 44.74 

Children 3-5:

 0.125606 12.56 0.181399 18.14 0.276584 27.66 

Children 6-12:

 0.075624 7.56 0.115439 11.54 0.186328 18.63 

Youth 13-19:

 0.046354 4.64 0.071801 7.18 0.117196 11.72 

Adults 20-49:

 0.053000 5.30 0.075334 7.53 0.118274 11.83 

Adults 50-99:

 0.050326 5.03 0.074209 7.42 0.107443 10.74 

Female 13-49:

 0.052999 5.30 0.078727 7.87 0.118210 11.82 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 16 of 25

Attachment 3: Average Field Trial Residues and Processing Factors Used in the Chronic Assessment

Table A.3. Summary of Residues and Processing Factors used in the Chronic Assessment1. 

Crop Commodity Residue 

(ppm)

Processing 

Factor %CT Comments

Potato and Sweet Potato

RAC 0.171 1 100

Potato residues translated to sweet potato using HED SOP 2000.1. Other members of crop group 

1C used tolerance-level residues. Future assessments could incorporate average field-trial (FT) 

residues for these commodities. Average FT residue. Used 150 OD formulation because had 

highest average residue. Memo, G. Kramer, 17-APR-2008; D339694.

Dried 1.6 1 100 Tolerance-level residue. Processing factor set to 1 because separate tolerance established in 40 CFR 

§180.641.

Onion

RAC 0.80 1 100 HED-recommended tolerance-level residue. 

Dried 0.80 9.0 100 HED-recommended tolerance-level residue. DEEM 7.81 default processing factor.

Head Lettuce RAC 0.605 1 100 Average FT residue. Used 100 OD formulation because had highest average residue. Memo, G. 

Kramer, 17-APR-2008; D339694.

Leaf Lettuce RAC 0.882 1 100 Average FT residue. Used 100 OD formulation because had highest average residue. Memo, G. 

Kramer, 17-APR-2008; D339694.

Spinach RAC 2.496 1 100 Average FT residue. Used 240 SC formulation because had highest average residue. Memo, G. 

Kramer, 17-APR-2008; D339694.

Edible-podded beans (6A) RAC 0.444 1 100 Average snap bean FT residue. Used OD formulation because had highest average residue. Memo, 

G. Kramer, 23-DEC-2010; D362952.

Edible-podded peas (6A) RAC 1.28 1 100 Average snow pea FT residue. Used SC formulation because had highest average residue. Memo, 

G. Kramer, 23-DEC-2010; D362952.

Succulent shelled beans (6B) RAC 0.243 1 100 Average lima bean FT residue. Used OD formulation because had highest average residue. Memo, 

G. Kramer, 23-DEC-2010; D362952.

Succulent shelled peas (6B) RAC 0.583 1 100 Average garden pea FT residue. Used OD formulation because had highest average residue. 

Memo, G. Kramer, 23-DEC-2010; D362952.

Tomato

RAC 2.5 1 100 Tolerance-level residue. 

Dried 2.5 12 100 Tolerance-level residue. Empirical processing factor from Memo, G. Kramer, 17-APR-2008; 

D339694.

Juice 2.5 0.9 100 Tolerance-level residue. Empirical processing factor from Memo, G. Kramer, 17-APR-2008; 

D339694.

Paste 2.5 1 100

Tolerance-level residue. Processing factor set to 1 because a separate tolerance was not required

based on the available processing data and the tolerance-level values were used in the assessment 

(Memo, G. Kramer, 17-APR-2008; D339694).

Puree 2.5 1 100

Tolerance-level residue. Processing factor set to 1 because a separate tolerance was not required

based on the available processing data and the tolerance-level values were used in the assessment 

(Memo, G. Kramer, 17-APR-2008; D339694).

Grapefruit

RAC 0.60 1 100 Tolerance-level residue. 

Juice 0.60 2.1 100 Tolerance-level residue. DEEM 7.81 default processing factor.
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 17 of 25

Table A.3. Summary of Residues and Processing Factors used in the Chronic Assessment1. 

Crop Commodity Residue 

(ppm)

Processing 

Factor %CT Comments

Lemon

RAC 0.60 1 100 Tolerance-level residue. 

Juice 0.60 2.0 100 Tolerance-level residue. DEEM 7.81 default processing factor.

Lime

RAC 0.60 1 100 Tolerance-level residue. 

Juice 0.60 2.0 100 Tolerance-level residue. DEEM 7.81 default processing factor.

Orange

RAC 0.60 1 100 Tolerance-level residue. 

Juice 0.60 0.4 100 Tolerance-level residue. Empirical processing factor from Memo, G. Kramer, 17-APR-2008; 

D339694.

Tangerine

RAC 0.60 1 100 Tolerance-level residue. 

Juice 0.60 2.3 100 Tolerance-level residue. DEEM 7.81 default processing factor.

Apple

RAC 0.152 1 100 Average FT residue. Used concentrated 150 OD formulation because had highest average residue. 

Memo, G. Kramer, 17-APR-2008; D339694.

Dried 0.152 1 100 Average FT residue. Empirical processing factor from Memo, G. Kramer, 17-APR-2008; D339694.

Juice 0.152 0.4 100 Average FT residue. Empirical processing factor from Memo, G. Kramer, 17-APR-2008; D339694.

Sauce 0.152 0.1 100 Average FT residue. Empirical processing factor from Memo, G. Kramer, 17-APR-2008; D339694.

Pear

RAC 0.205 1 100 Average FT residue. Used concentrated 150 OD formulation because had highest average residue. 

Memo, G. Kramer, 17-APR-2008; D339694.

Dried 0.205 6.25 100 Average FT residue. DEEM 7.81 default processing factor.

Juice 0.205 1 100 Average FT residue.

Apricot

RAC 4.50 1 100 Tolerance-level residue. 

Dried 4.50 6.0 100 Tolerance-level residue. DEEM 7.81 default processing factor.

Juice 4.50 1 100 Tolerance-level residue. 

Cherry

RAC 1.480 1 100 Average FT residue. Used dilute 150 OD formulation because had highest average residue. Memo, 

G. Kramer, 17-APR-2008; D339694.

Juice 1.480 1.5 100 Average FT residue. DEEM 7.81 default processing factor.

Peach

RAC 0.692 1 100 Average FT residue. Used dilute 150 OD formulation because had highest average residue. Memo, 

G. Kramer, 17-APR-2008; D339694. 

Dried 0.692 7.0 100 Average FT residue. DEEM 7.81 default processing factor.

Juice 0.692 1 100 Average FT residue. 

RAC 4.5 1 100 Tolerance-level residue. 

Plum, prune

Dried 4.5 1 100

Tolerance-level residue. Processing factor set to 1 because a separate tolerance was not required 

based on the available processing data and the tolerance-level values were used in the assessment 

(Memo, G. Kramer, 17-APR-2008; D339694).

Juice 4.5 1.4 100 Tolerance-level residue. DEEM 7.81 default processing factor.
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 18 of 25

Table A.3. Summary of Residues and Processing Factors used in the Chronic Assessment1. 

Crop Commodity Residue 

(ppm)

Processing 

Factor %CT Comments

Cranberry

RAC 0.30 1 100 HED-recommended tolerance-level residue. 

Juice 0.30 1.1 100 HED-recommended tolerance-level residue. DEEM 7.81 default processing factor.

Grape

RAC 0.412 1 100 Average FT residue. Used OD formulation because had highest average residue. Memo, G. 

Kramer, 17-APR-2008; D339694.

Juice 0.412 0.66 100 Average FT residue. Empirical processing factor from Memo, G. Kramer, 17-APR-2008; D339694.

Raisin 3.0 1 100 Tolerance-level residue. Processing factor set to 1 because separate tolerance established in 40 CFR 

§180.641.

Beef, meat Dried 0.02 1.92 100 Tolerance-level residue. DEEM 7.81 default processing factor.

Banana and plantain

RAC 1.3 1 100 Average FT residue from Memo, G. Kramer, 26-MAR-2013; D398856.

Dried 1.3 3.9 100 Average FT residue. DEEM 7.81 default processing factor.

Feijoa RAC 2.5 1 100

This tolerance is incorrect in the 40CFR. Since the HED-recommended tolerance of 2.5 ppm 

(Memo, J. Van Alstine et al., 22-DEC-2010; D368785) is greater than the tolerance in the 40 CFR, 

the higher HED-recommended tolerance has been used.

Lychee, dried

RAC 13.0 1 100 Tolerance-level residue.

Dried 13.0 1.85 100 Tolerance-level residue. DEEM 7.81 default processing factor.

Papaya

RAC 2.5 1 100

Tolerance-level residue, as included 40CFR. Although the HED-recommended tolerance is 0.35 

ppm, 2.5 ppm was used to be conservative. HED has notified RD that the tolerance should be 

updated to reflect the HED-recommended tolerance of 0.35 ppm. DEEM 7.81 default processing 

factor.

Dried 2.5 1.8 100 Tolerance-level residue, as included 40CFR. DEEM 7.81 default processing factor.

Juice 2.5 1.5 100 Tolerance-level residue, as included 40CFR. DEEM 7.81 default processing factor.

Persimmon RAC 2.5 1 100

This tolerance was recommended in Memo, J. Van Alstine et al., 22-DEC-2010 (D368785), 

however it was excluded from the 40CFR. It has been included in the assessment since a tolerance 

was recommended. 

Pineapple

RAC 0.30 1 100 HED-recommended tolerance-level residue. 

Dried 0.30 5.0 100 HED-recommended tolerance-level residue. DEEM 7.81 default processing factor.

Juice 0.30 0.72 100 HED-recommended tolerance-level residue. Empirical processing factor from Memo, G. Kramer, 

26-MAR-2013; D398856.

Spanish lime RAC 13.0 1 100

This tolerance is incorrect in the 40CFR. Since the HED-recommended tolerance of 13.0 ppm 

(Memo, J. Van Alstine et al., 22-DEC-2010; D368785) is greater than the tolerance in the 40 CFR, 

the higher HED-recommended tolerance has been used.

1 Tolerance-level residues were assumed for the remaining commodities with tolerances that are not included in this table. 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 19 of 25

Attachment 4: Chronic Food plus Water Residue Input File

Filename: C:\Documents and Settings\jlangsda\My Documents\Chemicals\Spirotetramat\2012 

RCC\Dietary\Sent to Reviewers\updated to include Kiwi\updated SPIROTETRAMAT__CHRONIC__21 

Dec 2012.R08

Chemical: Spirotetramat

RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 12-21-2012/11:38:57 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0103015000 1CD Arrowroot, flour 0.600000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.600000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.600000 1.000 1.000 

0103082000 1CD Cassava 0.600000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.600000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.600000 1.000 1.000 

0103166000 1CD Ginger 0.600000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.600000 1.000 1.000 

0103167000 1CD Ginger, dried 0.600000 1.000 1.000 

0103296000 1C Potato, chips 0.171000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 1.600000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 1.600000 1.000 1.000 

0103298000 1C Potato, flour 1.600000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 1.600000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.171000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.171000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.171000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.171000 1.000 1.000 

0103366000 1CD Sweet potato 0.171000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.171000 1.000 1.000 

0103371000 1CD Tanier, corm 0.600000 1.000 1.000 

0103387000 1CD Turmeric 0.600000 1.000 1.000 

0103406000 1CD Yam, true 0.600000 1.000 1.000 

0103407000 1CD Yam bean 0.600000 1.000 1.000 

0301165000 3A Garlic, bulb 0.800000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.800000 1.000 1.000 

0301237000 3A Onion, bulb 0.800000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.800000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.800000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.800000 9.000 1.000 

0301338000 3A Shallot, bulb 0.800000 1.000 1.000 

0302103000 3B Chive, fresh leaves 0.800000 1.000 1.000 

0302198000 3B Leek 0.800000 1.000 1.000 

0302239000 3B Onion, green 0.800000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 0.800000 1.000 1.000 

0401005000 4A Amaranth, leafy 9.000000 1.000 1.000 

0401018000 4A Arugula 9.000000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 9.000000 1.000 1.000 

0401133000 4A Cress, garden 9.000000 1.000 1.000 

0401134000 4A Cress, upland 9.000000 1.000 1.000 

0401138000 4A Dandelion, leaves 9.000000 1.000 1.000 

0401150000 4A Endive 9.000000 1.000 1.000 

0401204000 4A Lettuce, head 0.605000 1.000 1.000 

0401205000 4A Lettuce, leaf 0.882000 1.000 1.000 

0401248000 4A Parsley, leaves 9.000000 1.000 1.000 

0401313000 4A Radicchio 9.000000 1.000 1.000 

0401355000 4A Spinach 2.496000 1.000 1.000 

0401355001 4A Spinach-babyfood 2.496000 1.000 1.000 

0402076000 4B Cardoon 9.000000 1.000 1.000 

0402085000 4B Celery 9.000000 1.000 1.000 

0402085001 4B Celery-babyfood 9.000000 1.000 1.000 

0402086000 4B Celery, juice 9.000000 1.000 1.000 

0402087000 4B Celtuce 9.000000 1.000 1.000 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 20 of 25

0402152000 4B Fennel, Florence 9.000000 1.000 1.000 

0402322000 4B Rhubarb 9.000000 1.000 1.000 

0402367000 4B Swiss chard 9.000000 1.000 1.000 

0501061000 5A Broccoli 2.500000 1.000 1.000 

0501061001 5A Broccoli-babyfood 2.500000 1.000 1.000 

0501062000 5A Broccoli, Chinese 2.500000 1.000 1.000 

0501064000 5A Brussels sprouts 2.500000 1.000 1.000 

0501069000 5A Cabbage 2.500000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 2.500000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 2.500000 1.000 1.000 

0501083000 5A Cauliflower 2.500000 1.000 1.000 

0501196000 5A Kohlrabi 2.500000 1.000 1.000 

0502063000 5B Broccoli raab 8.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 8.000000 1.000 1.000 

0502117000 5B Collards 8.000000 1.000 1.000 

0502194000 5B Kale 8.000000 1.000 1.000 

0502229000 5B Mustard greens 8.000000 1.000 1.000 

0502318000 5B Rape greens 8.000000 1.000 1.000 

0502389000 5B Turnip, greens 8.000000 1.000 1.000 

0600347000 6 Soybean, seed 5.000000 1.000 1.000 

0600349000 6 Soybean, soy milk 5.000000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 5.000000 1.000 1.000 

0600350000 6 Soybean, oil 5.000000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 5.000000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.444000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.444000 1.000 1.000 

0601257000 6A Pea, edible podded, succulent 1.280000 1.000 1.000 

0601349500 6AB Soybean, vegetable 5.000000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.243000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.243000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.243000 1.000 1.000 

0602255000 6B Pea, succulent 0.583000 1.000 1.000 

0602255001 6B Pea, succulent-babyfood 0.583000 1.000 1.000 

0602259000 6B Pea, pigeon, succulent 0.583000 1.000 1.000 

0603030000 6C Bean, black, seed 2.500000 1.000 1.000 

0603032000 6C Bean, broad, seed 2.500000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 2.500000 1.000 1.000 

0603035000 6C Bean, great northern, seed 2.500000 1.000 1.000 

0603036000 6C Bean, kidney, seed 2.500000 1.000 1.000 

0603038000 6C Bean, lima, seed 2.500000 1.000 1.000 

0603039000 6C Bean, mung, seed 2.500000 1.000 1.000 

0603040000 6C Bean, navy, seed 2.500000 1.000 1.000 

0603041000 6C Bean, pink, seed 2.500000 1.000 1.000 

0603042000 6C Bean, pinto, seed 2.500000 1.000 1.000 

0603098000 6C Chickpea, seed 2.500000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 2.500000 1.000 1.000 

0603099000 6C Chickpea, flour 2.500000 1.000 1.000 

0603182000 6C Guar, seed 2.500000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 2.500000 1.000 1.000 

0603203000 6C Lentil, seed 2.500000 1.000 1.000 

0603256000 6C Pea, dry 2.500000 1.000 1.000 

0603256001 6C Pea, dry-babyfood 2.500000 1.000 1.000 

0603258000 6C Pea, pigeon, seed 2.500000 1.000 1.000 

0603348000 6C Soybean, flour 5.000000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 5.000000 1.000 1.000 

0801374000 8A Tomatillo 2.500000 1.000 1.000 

0801375000 8A Tomato 2.500000 1.000 1.000 

0801375001 8A Tomato-babyfood 2.500000 1.000 1.000 

0801376000 8A Tomato, paste 2.500000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 2.500000 1.000 1.000 

0801377000 8A Tomato, puree 2.500000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 2.500000 1.000 1.000 

0801378000 8A Tomato, dried 2.500000 12.000 1.000 

0801378001 8A Tomato, dried-babyfood 2.500000 12.000 1.000 

0801379000 8A Tomato, juice 2.500000 0.900 1.000 

0801380000 8A Tomato, Tree 2.500000 1.000 1.000 

0802148000 8BC Eggplant 2.500000 1.000 1.000 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 21 of 25

0802234000 8BC Okra 2.500000 1.000 1.000 

0802270000 8B Pepper, bell 2.500000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 2.500000 1.000 1.000 

0802271000 8B Pepper, bell, dried 2.500000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 2.500000 1.000 1.000 

0802272000 8BC Pepper, nonbell 2.500000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 2.500000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 2.500000 1.000 1.000 

0901075000 9A Cantaloupe 0.300000 1.000 1.000 

0901187000 9A Honeydew melon 0.300000 1.000 1.000 

0901399000 9A Watermelon 0.300000 1.000 1.000 

0901400000 9A Watermelon, juice 0.300000 1.000 1.000 

0902021000 9B Balsam pear 0.300000 1.000 1.000 

0902088000 9B Chayote, fruit 0.300000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.300000 1.000 1.000 

0902135000 9B Cucumber 0.300000 1.000 1.000 

0902308000 9B Pumpkin 0.300000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.300000 1.000 1.000 

0902356000 9B Squash, summer 0.300000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.300000 1.000 1.000 

0902357000 9B Squash, winter 0.300000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.300000 1.000 1.000 

1001106000 10A Citron 0.600000 1.000 1.000 

1001107000 10A Citrus hybrids 0.600000 1.000 1.000 

1001108000 10A Citrus, oil 6.000000 1.000 1.000 

1001240000 10A Orange 0.600000 1.000 1.000 

1001241000 10A Orange, juice 0.600000 0.400 1.000 

1001241001 10A Orange, juice-babyfood 0.600000 0.400 1.000 

1001242000 10A Orange, peel 0.600000 1.000 1.000 

1001369000 10A Tangerine 0.600000 1.000 1.000 

1001370000 10A Tangerine, juice 0.600000 2.300 1.000 

1002197000 10B Kumquat 0.600000 1.000 1.000 

1002199000 10B Lemon 0.600000 1.000 1.000 

1002200000 10B Lemon, juice 0.600000 2.000 1.000 

1002200001 10B Lemon, juice-babyfood 0.600000 2.000 1.000 

1002201000 10B Lemon, peel 0.600000 1.000 1.000 

1002206000 10B Lime 0.600000 1.000 1.000 

1002207000 10B Lime, juice 0.600000 2.000 1.000 

1002207001 10B Lime, juice-babyfood 0.600000 2.000 1.000 

1003180000 10C Grapefruit 0.600000 1.000 1.000 

1003181000 10C Grapefruit, juice 0.600000 2.100 1.000 

1003307000 10C Pummelo 0.600000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.152000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.152000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.152000 1.000 1.000 

1100009000 11 Apple, dried 0.152000 1.000 1.000 

1100009001 11 Apple, dried-babyfood 0.152000 1.000 1.000 

1100010000 11 Apple, juice 0.152000 0.400 1.000 

1100010001 11 Apple, juice-babyfood 0.152000 0.400 1.000 

1100011000 11 Apple, sauce 0.152000 0.100 1.000 

1100011001 11 Apple, sauce-babyfood 0.152000 0.100 1.000 

1100129000 11 Crabapple 0.700000 1.000 1.000 

1100173500 11 Goji berry 2.500000 1.000 1.000 

1100210000 11 Loquat 0.700000 1.000 1.000 

1100266000 11 Pear 0.205000 1.000 1.000 

1100266001 11 Pear-babyfood 0.205000 1.000 1.000 

1100267000 11 Pear, dried 0.205000 6.250 1.000 

1100268000 11 Pear, juice 0.205000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.205000 1.000 1.000 

1100310000 11 Quince 0.700000 1.000 1.000 

1201090000 12A Cherry 1.480000 1.000 1.000 

1201090001 12A Cherry-babyfood 1.480000 1.000 1.000 

1201091000 12A Cherry, juice 1.480000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 1.480000 1.500 1.000 

1202012000 12B Apricot 4.500000 1.000 1.000 

1202012001 12B Apricot-babyfood 4.500000 1.000 1.000 

1202013000 12B Apricot, dried 4.500000 6.000 1.000 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 22 of 25

1202014000 12B Apricot, juice 4.500000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 4.500000 1.000 1.000 

1202230000 12B Nectarine 4.500000 1.000 1.000 

1202260000 12B Peach 0.692000 1.000 1.000 

1202260001 12B Peach-babyfood 0.692000 1.000 1.000 

1202261000 12B Peach, dried 0.692000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 0.692000 7.000 1.000 

1202262000 12B Peach, juice 0.692000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.692000 1.000 1.000 

1203285000 12C Plum 4.500000 1.000 1.000 

1203285001 12C Plum-babyfood 4.500000 1.000 1.000 

1203286000 12C Plum, prune, fresh 4.500000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 4.500000 1.000 1.000 

1203287000 12C Plum, prune, dried 4.500000 1.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 4.500000 1.000 1.000 

1203288000 12C Plum, prune, juice 4.500000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 4.500000 1.400 1.000 

1302057000 13B Blueberry 3.000000 1.000 1.000 

1302057001 13B Blueberry-babyfood 3.000000 1.000 1.000 

1302136000 13B Currant 3.000000 1.000 1.000 

1302137000 13B Currant, dried 3.000000 1.000 1.000 

1302149000 13B Elderberry 3.000000 1.000 1.000 

1302174000 13B Gooseberry 3.000000 1.000 1.000 

1302191000 13B Huckleberry 3.000000 1.000 1.000 

1304175000 13D Grape 0.412000 1.000 1.000 

1304176000 13D Grape, juice 0.412000 0.660 1.000 

1304176001 13D Grape, juice-babyfood 0.412000 0.660 1.000 

1304179000 13D Grape, wine and sherry 0.412000 1.000 1.000 

1304195000 13D Kiwifruit, fuzzy 1.300000 1.000 1.000 

1307130000 13G Cranberry 0.300000 1.000 1.000 

1307130001 13G Cranberry-babyfood 0.300000 1.000 1.000 

1307131000 13G Cranberry, dried 0.300000 1.000 1.000 

1307132000 13G Cranberry, juice 0.300000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 0.300000 1.100 1.000 

1307359000 13G Strawberry 0.400000 1.000 1.000 

1307359001 13G Strawberry-babyfood 0.400000 1.000 1.000 

1307360000 13G Strawberry, juice 0.400000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 0.400000 1.000 1.000 

1400003000 14 Almond 0.250000 1.000 1.000 

1400003001 14 Almond-babyfood 0.250000 1.000 1.000 

1400004000 14 Almond, oil 0.250000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.250000 1.000 1.000 

1400059000 14 Brazil nut 0.250000 1.000 1.000 

1400068000 14 Butternut 0.250000 1.000 1.000 

1400081000 14 Cashew 0.250000 1.000 1.000 

1400092000 14 Chestnut 0.250000 1.000 1.000 

1400155000 14 Hazelnut 0.250000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.250000 1.000 1.000 

1400185000 14 Hickory nut 0.250000 1.000 1.000 

1400213000 14 Macadamia nut 0.250000 1.000 1.000 

1400269000 14 Pecan 0.250000 1.000 1.000 

1400282000 14 Pistachio 0.250000 1.000 1.000 

1400391000 14 Walnut 0.250000 1.000 1.000 

1500127000 15 Corn, sweet 1.500000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 1.500000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.300000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.300000 1.000 1.000 

3100044000 31 Beef, meat 0.020000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.020000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.020000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.200000 1.000 1.000 

3100047000 31 Beef, fat 0.020000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.020000 1.000 1.000 

3100048000 31 Beef, kidney 0.200000 1.000 1.000 

3100049000 31 Beef, liver 0.200000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.200000 1.000 1.000 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 23 of 25

3200169000 32 Goat, meat 0.020000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 

3200171000 32 Goat, fat 0.020000 1.000 1.000 

3200172000 32 Goat, kidney 0.200000 1.000 1.000 

3200173000 32 Goat, liver 0.200000 1.000 1.000 

3300189000 33 Horse, meat 0.020000 1.000 1.000 

3400291000 34 Pork, skin 0.020000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.020000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.020000 1.000 1.000 

3400294000 34 Pork, kidney 0.020000 1.000 1.000 

3400295000 34 Pork, liver 0.020000 1.000 1.000 

3500339000 35 Sheep, meat 0.020000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.020000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 

3500341000 35 Sheep, fat 0.020000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.020000 1.000 1.000 

3500342000 35 Sheep, kidney 0.200000 1.000 1.000 

3500343000 35 Sheep, liver 0.200000 1.000 1.000 

3600222000 36 Milk, fat 0.010000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.010000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.010000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 

3600224000 36 Milk, water 0.010000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.010000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 

3800221000 38 Meat, game 0.020000 1.000 1.000 

4000094000 40 Chicken, liver 0.020000 1.000 1.000 

4000095000 40 Chicken, meat byproducts 0.020000 1.000 1.000 

4000095001 40 Chicken, meat byproducts-babyfoo 0.020000 1.000 1.000 

4000097000 40 Chicken, skin 0.020000 1.000 1.000 

4000097001 40 Chicken, skin-babyfood 0.020000 1.000 1.000 

5000383000 50 Turkey, liver 0.020000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.020000 1.000 1.000 

5000384000 50 Turkey, meat byproducts 0.020000 1.000 1.000 

5000384001 50 Turkey, meat byproducts-babyfood 0.020000 1.000 1.000 

5000386000 50 Turkey, skin 0.020000 1.000 1.000 

5000386001 50 Turkey, skin-babyfood 0.020000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.020000 1.000 1.000 

6000303000 60 Poultry, other, meat byproducts 0.020000 1.000 1.000 

6000305000 60 Poultry, other, skin 0.020000 1.000 1.000 

7000145000 70 Egg, whole 0.020000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.020000 1.000 1.000 

7000146000 70 Egg, white 0.020000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.020000 1.000 1.000 

7000147000 70 Egg, yolk 0.020000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.020000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.395000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.395000 1.000 1.000 

9500001000 O Acerola 2.500000 1.000 1.000 

9500016000 O Artichoke, globe 1.500000 1.000 1.000 

9500020000 O Avocado 0.600000 1.000 1.000 

9500023000 O Banana 1.300000 1.000 1.000 

9500023001 O Banana-babyfood 1.300000 1.000 1.000 

9500024000 O Banana, dried 1.300000 3.900 1.000 

9500024001 O Banana, dried-babyfood 1.300000 3.900 1.000 

9500074000 O Canistel 0.600000 1.000 1.000 

9500115000 O Coffee, roasted bean 0.200000 1.000 1.000 

9500116000 O Coffee, instant 0.500000 1.000 1.000 

9500151000 O Feijoa 2.500000 1.000 1.000 

9500177000 O Grape, leaves 0.412000 1.000 1.000 

9500178000 O Grape, raisin 3.000000 1.000 1.000 

9500183000 O Guava 2.500000 1.000 1.000 

9500183001 O Guava-babyfood 2.500000 1.000 1.000 

9500188000 O Hop 10.000000 1.000 1.000 

9500209000 O Longan 13.000000 1.000 1.000 

9500211000 O Lychee 13.000000 1.000 1.000 

9500212000 O Lychee, dried 13.000000 1.850 1.000 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 24 of 25

9500215000 O Mango 0.600000 1.000 1.000 

9500215001 O Mango-babyfood 0.600000 1.000 1.000 

9500216000 O Mango, dried 0.600000 1.000 1.000 

9500217000 O Mango, juice 0.600000 1.000 1.000 

9500217001 O Mango, juice-babyfood 0.600000 1.000 1.000 

9500245000 O Papaya 2.500000 1.000 1.000 

9500245001 O Papaya-babyfood 2.500000 1.000 1.000 

9500246000 O Papaya, dried 2.500000 1.800 1.000 

9500247000 O Papaya, juice 2.500000 1.500 1.000 

9500252000 O Passionfruit 2.500000 1.000 1.000 

9500252001 O Passionfruit-babyfood 2.500000 1.000 1.000 

9500253000 O Passionfruit, juice 2.500000 1.000 1.000 

9500253001 O Passionfruit, juice-babyfood 2.500000 1.000 1.000 

9500277000 O Persimmon 2.500000 1.000 1.000 

9500279000 O Pineapple 0.300000 1.000 1.000 

9500279001 O Pineapple-babyfood 0.300000 1.000 1.000 

9500280000 O Pineapple, dried 0.300000 5.000 1.000 

9500281000 O Pineapple, juice 0.300000 0.720 1.000 

9500281001 O Pineapple, juice-babyfood 0.300000 0.720 1.000 

9500283000 O Plantain 1.300000 1.000 1.000 

9500284000 O Plantain, dried 1.300000 3.900 1.000 

9500289000 O Pomegranate 0.500000 1.000 1.000 

9500333000 O Sapote, Mamey 0.600000 1.000 1.000 

9500351000 O Spanish lime 13.000000 1.000 1.000 

9500358000 O Starfruit 2.500000 1.000 1.000 

9500398000 O Watercress 2.000000 1.000 1.000 
Spirotetramat Dietary Exposure and Risk Assessment DP No. 398858

Page 25 of 25

Attachment 5: Chronic Results File

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for SPIROTETRAMAT NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\jlangsda\My 

Documents\Chemicals\Spirotetramat\2012 RCC\Dietary\Sent to Reviewers\updated to include 

Kiwi\updated SPIROTETRAMAT__CHRONIC__21 Dec 2012.R08

 Adjustment factor #2 used.

Analysis Date 12-21-2012/13:21:54 Residue file dated: 12-21-2012/11:38:57

Reference dose (RfD, Chronic) = .05 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.017785 35.6%

Hispanic 0.018737 37.5%

Non-Hisp-White 0.017748 35.5%

Non-Hisp-Black 0.015575 31.1%

Non-Hisp-Other 0.021071 42.1%

Nursing Infants 0.016243 32.5%

Non-Nursing Infants 0.046105 92.2%

Female 13+ PREG 0.016541 33.1%

Children 1-6 0.032850 65.7%

Children 7-12 0.018046 36.1%

Male 13-19 0.012837 25.7%

Female 13-19/NP 0.013480 27.0%

Male 20+ 0.015660 31.3%

Female 20+/NP 0.016866 33.7%

Seniors 55+ 0.016343 32.7%

All Infants 0.036886 73.8%

Female 13-50 0.015912 31.8%

Children 1-2 0.038038 76.1%

Children 3-5 0.030925 61.9%

Children 6-12 0.019418 38.8%

Youth 13-19 0.013149 26.3%

Adults 20-49 0.016159 32.3%

Adults 50-99 0.016494 33.0%

Female 13-49 0.015902 31.8%

-------------------------------------------------------------------------------