### Page 1 of 25 

## UNITED STA **TES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460**  **OFFICE OF CHEMICAL SAFETY AND**  **POLLUTION PREVENTION** 

## MEMORANDUM **DATE** : 26 - MAR - 201 3 **SUBJECT** : **Spirotetramat:** Acute and Chronic Dietary (Food and Drinking Water) Exposure and Risk Assessment to Support the Section 3 Registration Request For Use of Spirotetramat on Taro, Leaves; Watercress; Pomegranate; Banana; Vegetable, Bulb, Group 3 - 07; Low growing Berry Subgroup 13 - 07H, Except Strawberry and Lowbush Blueberry ; Bushberry Subgroup 13 - 07B; Artichoke, Globe; Vegetable, Fruiting, Group 8 - 10; Fruit, Pome, Group 11 - 10; Fruit, Citrus, Group 10 - 10; Pineapple; and Coffee; and Tolerances without U.S. Registration in/on Corn, Sweet, Kernel Plus Cob with Husks Removed as Part of the U.S. - Canada Regulatory

Cooperation Council (RCC) Pilot Project .

**FROM:** Julie L . Van Alstine, MPH, Environmental Health Scientist

Risk Assessment Branch 1 (RAB1)/Health Effects Division (HED; 7509P) **THROUGH:** Douglas A. Dotson, Ph.D., Chemist

Kristin Rury , Biologist Dietary Exposure Science Advisory Council (DESAC) HED (7509P) and George F. Kramer, Ph.D., Branch Senior Chemist RAB1/HED (7509P) **TO:** Barbara Madden/Laura Nollen, RM 05

Registration Division (RD; 7505P) **Executive Summary** Acute and chronic dietary- exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM - FCID) **PC Code:** 392201 **DP No.:** D398858 **Decision No.:** 459092 **Registration No. :**  264 - 1050 **Petition No.:** 1E7958 **Regulatory Action:** Section 3 **Risk Assessment Type:** Dietary **Case No.:** 7452 **T XR No.:**  NA **CAS No.:** 203313 - 25 - 1 **MRID No.:** NA **40 CFR:** §180.641

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## Version 3.16, which uses food consumption data from the U.S. Department of Agriculture’s National Health and Nutrition Examination Survey , What We Eat in America, (NHANES/WWEIA) from 2003 through 2008. The anal ys es were performed to support a proposed Sec tion 3 registration request by Interregional Research Project Number 4 (IR - 4) for the application of the active ingredient spirotetramat ( cis - 3 - (2,5 - dimethylphenyl) - 8 - methoxy- 2 - oxo - 1 - azaspiro[4.5]dec - 3 - en - 4 - ylethylcarbonate ) to taro, watercress, pomegran ates, bananas, bulb vegetables, low - growing berries (except strawberries), bushberries, globe artichokes, fruiting vegetables, pome fruit, citrus fruit, pineapples, and coffee and, as part of the U.S. - Canada Regulatory

Cooperation Council (RCC) pilot proje ct 1 

## , the establishment of a tolerance without U.S. registration for residues of spirotetramat in/on corn, sweet, kernel plus cob with husks removed . These analy ses have been reviewed by two peer reviewers of the DESAC , per the DESAC Standard Operating Pro cedure ( SOP ) 2012.1 . Acute Dietary (Food and Drinking W ater) Exposure Results and Characterization The acute anal ys is assumed 100% crop treated (CT), tolerance - level residues for all foods, and DEEM 7.81 default processing factors (where provided). Dietary risk estimates were determined considering exposures from food plus drinking water using estimate d drinking water concentrations (EDWCs) for surface water sources provided by the Environmental Fate and Effects Division (EFED). EDWC values were generated using the watercress use pattern and the Tier 1 Rice Model v.1.0 since the proposed Section 3 use on watercress yi elded the highest acute EDWC values. The acute dietary risk assessment shows that for all included commodities, the acute dietary

risk estimates at the 95 th 

## percentile are not of concern to HED [i.e., <100% acute population - adjusted dose ( aPAD)]. The resulting acute dietary (food + water) risk estimates utilized 7 % of the aPAD for the general U.S. population and 16 % of the aPAD for children 1 - 2 ye ars old, the most highly exposed population subgroup. Chronic Dietary (Food and Drinking W ater) Exposure Results and Characterization The chronic dietary

assessment assumed 100% CT, average field trial residues for some commodities, and tolerance - level residues for the remaining commodities. Some empirical processing factors were used along with DEEM 7.81 default processing factors (where provided). EDWC values were generated using the watercress use pattern and the Tier 1 Rice Model v.1.0 since the proposed Section 3 use on watercress yi elded the highest chronic EDWC values. The chronic diet ary risk assessment shows that for all included commodities, the chronic dietary risk estimates are not of concern to HED [i.e., <100% chronic population - adjusted dose (cPAD)]. The resulting chronic dietary (food + water) risk estimates utilized 36 % of th e cPAD for the general U.S. population and 76 % of the cPAD for children 1 - 2 years old, the most highly exposed population subgroup. Cancer Spirotetramat was classified as “n ot l ikely to be c arcinogenic to humans”; therefore, a cancer dietary assessment was not performed.

1 

### For more information about the RCC pilot project, please refer to http://www.epa.gov/oppfead1/international/naftatwg/us - canada - rcc.html .

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## I. **Introduction** Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population - adjusted dose (PAD). The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g .) divided by the required uncertainty or safety factors. For acute and non - cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21 - JUN - 2000, web link: http://www.epa.gov/fedrgstr/EPA - PEST/2000/July /Day- 12/6061.pdf; or see SOP 99.6 (20 - AUG 1999). The most recent dietary

risk assessment for spirotetramat was conducted on 01 - AUG - 2012 (Memo, J. Van Alstine; D404051). **II. Residue Information**  Residues of Concern: The nature of the residue in plants, rotational crops, and livestock is adequatel y understood based on acceptable metabolism studies conducted on apple, lettuce, cotton, potato, rotational crops, lactating goats, and laying hens. The residues of concern for the tolerance expression and risk assessment for plant commodities are spirotetramat and its metabol ites BYI 08330 - enol, BYI 08330 - ketohydroxy, BYI08330 - enol - Glc, and BYI 08330 - mono - hydrox y. Based on the currently proposed uses, the residues of concern for the tolerance expression for livestock commodities are spirotetramat and its metabolite BYI 08330 - enol , and the residues of concern for the risk assessment for livestock commodities are spirotetramat and its metabolites BYI 08330 - enol and BYI 08330 - enol - GA (Memo, J. Tyler et al. , 4/16/08; D333437). Established Tolerances: Permanent tolerances for the combined residues of spirotetramat and its metabolites BYI 08330 - enol, BYI 08330 - ketohydroxy, BYI08330 - enol - Glc, and BYI 08330 - mono - hydrox y, calculated as spirotetramat equivalents, are currentl y established in/on a wide vari ety of crops (40 CFR §180.641). Recommended Tolerances: Based on the residue chemistry data submitted with the current petition, HED recommended for establishment of the tolerances outlined in Table 1 for the combined residues of spirotetramat and its metabolites BYI 08330 - enol, BYI 08330 - ketohydroxy , BY I08330 - enol - Glc, and BYI 08330 - mono - hydroxy , calculated as the stoichiometric equivalent of spirotetramat.

**Table 1. Tolerance Summary for Spirotetram at.**  **Comm odity**  **Recommended Tolerance (ppm)** Taro, leaves 9.0 Watercress 2.0 Pomegranate 0.50 Banana 1 

### 4.0

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 4 of 25 **Table 1. Tolerance Summary for Spirotetram at.**  **Comm odity**  **Recommended Tolerance (ppm)** Vegetable, bulb, group 3 - 07 0.80 Lo w growing berry subgroup 13 - 07H, except straw

berry and low bush blueberry 0.30 Bushberry subgroup 13 - 07B 3.0 Artichoke, globe 1.5 Vegetable, fruiting, group 8 - 10 2.5 Fruit, pome, group 11 - 10 0.70 Fruit, citrus, group 10 - 10 0.60 Pineapple 0.30 Coffee, green bean 0.20 Coffee, instant 0.50 Corn, sweet, kernel plus cob with husks removed2 

### 1.5 1 

### This tolerance should be established under 40 CFR §180.641(c) Tolerances with regional registrations. 2 

### There are no U.S. registrations as of [date] for use on corn, sweet. 

## Residue Data Used for Acute and Chronic Assessments: The acute assessment assumed tolerance - level residues. The chronic assessment incorporated average field trial residues for some commodities (see Attachment 3 ) and tolerance - level residues for the remaining commodities. Additionally , the potato average f ield trial residue was translated to sweet potatoes using HED SOP 2000.1. The residue levels for livestock commodities were not adjusted for the additional metabolite of concern for the risk assessment (BYI 08330 - enol - GA) as the tolerance level values are sufficient to cover the total residues of spirotetramat, BYI 08330 - enol, and BYI 08330 - enol - GA (G. Kramer, 09 - APR - 2010; D362952 ). The tolerances in 40 CFR §180.641 for residues in/on feijoa, papaya, and Spanish lime do not match the recommended tolerance s from the previous assessment ( Memo, J. Van Alstine et al. , 22 - DEC - 2010; D368785) . For feijoa and Spanish lime, the HED - recommended tolerances were higher than the tolerance in the 40 CFR; therefore, the recommended tolerances of 2.5 ppm and 13 ppm, resp ectively , were used in this assessment . For papaya, the HED - recommended tolerance of 0.35 ppm is lower than the tolerance in the 40 CFR; therefore, the higher tolerance of 2.5 ppm from the 40 CFR was used in this assessment as a conservative assumption. Additionally, HED recommended a tolerance of 2.5 ppm for residues in/on persimmon, which was excluded from the 40 CFR. This tolerance has been included in the assessment. Finally , the recommended tolerance of 0.80 ppm for the bulb vegetable subgroup 3 - 07 was used for the entire crop group because this tolerance will replace the currently

established tolerance of 0.30 ppm for bulb onion subgroup 3A - 07. The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010; however, the samples were not anal yz ed for spirotetramat. As a result, residues in fish were not included in the assessment. Processing Factors: For the acute assessment, DEEM 7.81 default processing factors were used (where provided). For the chronic assessment, empirical processing factors were used for the following processed commodities: apple, orange, grape, tomato, and pineapple juice; applesauce; and dried apple and tomato. The processing factors have been set to 1 for dried plums and tomato p aste and puree because separate tolerances were not required for these commodities based on the available processing data and since tolerance - level residues were used

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## in the assessment. DEEM 7.81 default processing factors were used for the remaining proc essed commodities (where provided). (See Attachment 3 . ) **III. Percent Crop Treated**  Both the acute and chronic assessments assumed 100% CT for all commodities. **IV. Drinking Water Data**  The drinking water residues used in the dietary risk assessment were provided by EFED (Memo, J. Meléndez , 19 - JUL - 2012; D398507 ). The drinking water models and their descriptions are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/ . Exposure to spirotetramat in surface water is possible through surface water runoff, soil erosion, and/or off - target spray

drift. The mobility

of spirotetramat is relativel y high [Kd 

## range 3.58 - 5.52 mL/g , KOC 

## range 184 - 437 mL/g OC 

## (moderately mobile)] and it is labile under many conditions, especiall y under aerobic soil metabolism conditions. Nonetheless, its total residues are relatively persistent. The Tier I EDWCs for spirotetramat and for its major transformation products, spirotetramat - enol and spiro tetramat - ketohydrox y, were calculated using SCI - GROW v.2.3 (groundwater, applications to bananas and plantains) and the Tier 1 Rice Model v.1.0 (surface water, as a surrogate for applications to watercress). The Tier 1 Rice Model v.1.0 resulted in the highest EDWC for use in the acute and chronic assessments. Therefore, the surface water EDWC value of 0.395 ppm was incorporated in DEEM - FCID into the food categories “water, direct, all sources” and “water, indirect, all sources” for both the acute and chro nic assessments. Watercress is typicall y grown in clean, flowing water, 2 to 3 inches deep. 2 

## Based on the previous review and information provided by the r egistrant and IR- 4, it appears that watercress is grown in a bed of water that drains to a ditch and is constantly recirculated. The circulation of water is stopped 24 hours before chemical application and is turned back on 24 hours after application. The Agency does not currently have a methodology

for exposure assessment for crops cultivated in fl owing water, such as watercress. The EFED Tier 1 Rice model v.1.0 has, therefore, been used as the basis of the assessment , and the results have been characterized to reflect differences between the capabilities of this model and the watercress cultivatio n practices. EFED is concerned primarily about the total toxic residues (TTR), as opposed to individual metabolites (spirotetramat, spirotetramat - enol , and spirotetramat - ketohydrox y) , from discharge towards adjacent bodies of water at the end of the sea son. Individual metabolites were not modeled because this would double count the mass of pesticide and the transformation products in this particular model. Rice cultivation differs from watercress cultivation in that for the latter, the water is constantl y flowing, while for rice, the field is flooded. The Tier 1 Rice Model v.1.0 provides a conservative, screening - level estimate. Crop interception, pesticide degradation, stream flow, and runoff dilution from the areas in the watershed which are not treated all have the potential to reduce the conservative EDWCs generated b y the Tier 1 Rice Model.

2 

### http://www.naturesherbal.com/Watercress.htm , and see also http://www.bwqualitygrowers.com/ourfarms.aspx accessed 03/27/2012.

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 6 of 25 **Table 2. Maximum Tier I EDWCs for D**  **rinking W**  **ater R** **isk A**  **ssessment B**  **ased on G**  **round or A**  **erial A** **pplication of S**  **pir otetram**  **at on P**  **lantains and B**  **ananas (for G**  **roundwater) at 1.25 lb a.i./A/ S**  **eason, and**  **G round,**  **A erial**  **, or**  **C hemigation**  **A pplications on**  **W atercress (for**  **S urface**  **W ater) at 0.4 lb**  **a.i./A/ S**  **eason. Drinking**  **Water Source (M**  **ODEL) EDWC** 

**Chemical: Parent** 

**Spirotetram at**  **Spirotetram at**  ****

**enol Spirotetram**  **at**  

** ketohydroxy** **Total Toxic**

**Residues (TTR) 1**  

### Risk **\ Units**  **(ppb) (ppb)**  **(ppb) (ppb)**  Ground - water (SCI - GROW) Ac ute &

Chronic 2 

### 7.06 x 10 - 5 

### 5.15 x 10 - 5 

### 1.12 x 10 - 3 

### 1.24 x 10 - 3 

### Surface Water (Tier 1 Rice Model v.1.0) Ac ute &

Chronic 2 

### N/A N/A N/A 395 1 

### TTR = Total Toxic Residues (sum of spirotetramat + spirotetramat - enol + spirotetramat - ketohydroxy) . 2 

### Surface - water concentrations calculated by the Tier I Rice Model v1.0 and ground water concentrations calculated by SCI - GROW do not distinguish between peak and chronic concentrations. 

## V. **DEEM -**  **FCID Program and Consumption Information** Spirotetramat acute and chronic dietary exposure assessments were conducted using DEEM FCID, Version 3.16, which incorporates consumption data from USDA’s NHANES/WWEIA from 2003 through 2008. The data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly

by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. However, for acute exposure assessment, consumption data are retained as individual consumption events. Based on anal ys is of the 2003 - 2008 WWEIA consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, adults 20 - 49, females 13 - 49, and adults 50 - 99 ye ars old. For a chronic dietary

exposure assessment, an estimate of the residue level in each food or food form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food f orm is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. For an acute exposure assessment, individual one - day food consumption data are used on an individual - by- individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who reported eating relevant commodities/food forms) and a per- capita (i.e., those who reported eating the relevant

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## commodities as well as those who did not) basis. In accordance with HED policy , per capita exposure and risk are reported for anal ys es performed at all levels of refinement. However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specificall y identified and noted in the risk assessment. **VI. Toxicological Information**  Table 3 summarizes the toxicological doses and endpoints for spirotetramat concerning dietary exposure assessment. The endpoints have been reviewed by the risk assessment team and are considered appropriate for the current risk assessment. **Table 3. Summary of Toxicological Doses and Endpoints for Spirotetram at**  **for Use in Dietary Hum an**  **- Health**  **Risk Assessments. Exposure Scenario**  **Point of Departure**  **Uncertainty/FQPA**

**Safety Factors RfD, PAD, LOC for** 

**Risk Assessment**  **Study and Relevant Toxicological Effects**  Acute Dietary (General Population, including Infants and Children) NOAEL = 100 mg/kg/day UF A = 10X

UF H = 10X UF FQPA = 1X aRfD = aPAD = 1.0

mg/kg/day **Acute neurotoxicity (rat; oral gavage)**  LOAEL = 200 mg/kg based on clinical signs (M&F) and decreased motor activity (M). Chronic Dietary (All Populations) NOAEL = 5 mg/kg/day UF A = 10X

UF H = 10X UF FQPA = 1X cRfD = cPAD = 0.05

mg/kg/day 1 **Chronic toxicity (dog; dietary)** LOAEL = 20 mg/kg/day (M) based on thy

mus involution. Cancer (Oral, Dermal, Inhalation) Classification: “not l ikely to be c arcinogenic to humans” based on lack of evidence of carcinogenicity in two oral rodent carcinogenicity studies. Abbreviations: UF = uncertainty factor, UFA = extrapolation from animal to human (interspecies), UF H = potential variation in sensitivity among members of the human population (intraspecies), UF FQPA = FQPA Safety Factor, NOAEL = no - observed adverse - effect level, LOAEL = lowest observed adverse - effe ct level, RfD = reference dose (a = acute, c = chronic), PAD = population - adjusted dose, LOC = level of concern. 1 The cRfD has been harmonized across American (USEPA), Canadian (PMRA), and Austrian (AGES) regulatory agencies. However, it is noted that US EPA considered a NOAEL = 6 mg/kg/day in males and a NOAEL = 19 mg/kg/day in females to more accurately reflect the toxicologi cal data. The difference between 5 mg/kg/day (NOAEL in females for PMRA and AGES) and 6 mg/kg/day was considered negligible for ri sk assessment. 

## VII. **Results/Discussion** For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM - FCID anal ys es estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 4 are for the general U.S. population, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, females 13 - 49, adults 20 - 49, and adults 50 - 99 years. Results of Acute and Chronic Dietary Exposure Analy ses The acute dietary

exposure for food and drinking water utilized 7% of the aPAD for the U.S. population. The acute dietary exposure estimate for the highest reported exposed population subgroup, children 1 - 2 years old, utilized 16% of the aPAD. The chroni c dietary exposure estimate for food and drinking water utilized 36% of the cPAD for the U.S. population. The chronic dietary

exposure for the highest reported exposed population subgroup, children 1 - 2 ye ars old, utilized 76% of the cPAD. Spirotetramat w as classified as “n ot likely to be carcinogenic to humans”; therefore, a cancer dietary assessment was not performed. The results of the acute and chronic dietary exposure anal ys es are reported in Table 4.

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 8 of 25 **Table 4. Summary of Dietary (Food and Drinki ng Water) Exposure Risk for Spirotetram**  **at 1**  

### . **Population Subgroup Acute Dietary (95**  **th** 

### Percentile) **Chronic Dietary Dietary Exposure**  **(m g/kg/day)**  **% aPAD Dietary Exposure**  **(m g/kg/day)**  **% cPAD** General U.S. Population 0.066115 7 0.017785 36 All Infants (<1 year old) 0.137642 14 0.036886 74 **Children 1 -**  **2 years old 0.155241**  **16 0.038038**  **76** Children 3 - 5 years old 0.125606 13 0.030925 62 Children 6 - 12 years old 0.075624 8 0.019418 39 Youth 13 - 19 years old 0.046354 5 0.013149 26 Adults 20 - 49 years old 0.053000 5 0.016159 32 Adults 50 - 99 years old 0.050326 5 0.016494 33 Females 13 - 49 years old 0.052999 5 0.015902 32 1 

### The values for the highest exposed population for each type of risk assessment are bolded. 

## Further refinement to the anal ys es could be made through the use of additional average field trial values and translation of average field trial residues to other commodities using HED SOP 2000.1, additional empirical processing factors, incorporation of percentages of crops treated with spirotetramat, o r monitoring data. Since risk estimates are below HED’s level of concern, a more highl y refined analysis is not required at this time. **VIII. Conclusions**  Acute and chronic dietary exposure and risk assessments were conducted for the proposed food uses and permanent tolerances of spirotetramat, including potential exposure from drinking water. The acute and chronic dietary (food + drinking water) exposure and risk estimates for spirotetramat are below HED’s level of concern for the general U.S. population and all population subgroups. The most highly exposed population subgroup for both the acute and chronic assessments was children 1 - 2 years old. This population subgroup utilized 16% of the aPAD and 76% of the cPAD. **IX. List of Attachments**  Attachment 1: Acute Food plus Water Residue Input File Attachment 2: Acute Results File Attachment 3: Average Field Trial Residues and Processing Factors Used in the Chronic

Assessment Attachment 4: Chronic Food plus Water Residue Input File Attachment 5: Chronic Results File RDI: DE SAC Reviewers: 11 - 26 - 2012 ; G. Kramer: 11 - 26 - 2012 DP No.: D398858 Petition No.: 1E7958 PC Code: 392201 J. L.Van Alstine:S - 10951:PY - S:(703)603 - 8866:7509P:RAB1

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## Attachment 1: Acute and Chronic Food plus Water Residue Input File Filename: C: \ Documents and Settings \ jlangsda \ My Documents \ Chemicals \ Spirotetramat \ 2012 RCC \ Dietary \ S ent to Reviewers \ updated to include Kiwi \ updated SPIROTETRAMAT__ACUTE__21 Dec 2012.R08 Chemical: Spirotetramat RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified : 12 - 21 - 2012/11:35:33 Program ver. 3.16, 03 - 08 - d Comment: + emp proc fact

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0103015000 1CD Arrowroot, flour 0.600000 1.000 1.000 0103015001 1CD Arro wroot, flour - babyfood 0.600000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.600000 1.000 1.000 0103082000 1CD Cassava 0.600000 1.000 1.000 0103082001 1CD Cassava - babyfood 0.600000 1.000 1.000 0103139000 1CD Dasheen, corm 0.600000 1.000 1.000 0103166000 1CD Ginger 0.600000 1.000 1.000 0103166001 1CD Ginger - babyfood 0.600000 1.000 1 .000 0103167000 1CD Ginger, dried 0.600000 1.000 1.000 0103296000 1C Potato, chips 0.600000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 1.600000 1.000 1.000 0103297001 1C Po tato, dry (granules/ flakes) - b 1.600000 1.000 1.000 0103298000 1C Potato, flour 1.600000 1.000 1.000 0103298001 1C Potato, flour - babyfood 1.600000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.600000 1.000 1.000 0103299001 1C Potato, tuber, w/peel - babyfood 0.600000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.600000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel - babyfood 0.600000 1.000 1.000 0103366000 1CD Sweet potato 0.600000 1.000 1.000 0103366001 1CD Sweet potato - babyfood 0.600000 1.000 1.000 0103371000 1CD Tanier, corm 0.600000 1.000 1.000 0103387000 1CD Turmeric 0.600000 1.000 1.000 0103406000 1CD Yam, true 0.600000 1.000 1.000 0103407000 1CD Yam bean 0.600000 1.000 1.000 0301165000 3A Garlic, bulb 0.800000 1.000 1.000 0301165001 3A Garlic, bulb - babyfood 0.800000 1.000 1.000 0301237000 3A Onion, bulb 0.800000 1.000 1.000 0301237001 3A Onion, bulb - babyfood 0.800000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.800000 9.000 1.000 0301238001 3A Onion, bulb, dried - babyfood 0.800000 9.000 1.000 0301338000 3A Shallot, bulb 0.800000 1.000 1.000 0302103000 3B Chive, fresh leaves 0.800000 1.000 1.000 0302198000 3B Leek 0.800000 1.000 1.000 0302239000 3B Onion, green 0.800000 1.000 1.000 0302338500 3B Shallot, fresh leav es 0.800000 1.000 1.000 0401005000 4A Amaranth, leafy 9.000000 1.000 1.000 0401018000 4A Arugula 9.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 9.000000 1.000 1.000 0401133000 4A Cress, garden 9.000000 1.000 1.000 0401134000 4A Cress, upland 9.000000 1.000 1.000 0401138000 4A Dandelion, leaves 9.000000 1.000 1.000 04011500 00 4A Endive 9.000000 1.000 1.000 0401204000 4A Lettuce, head 9.000000 1.000 1.000 0401205000 4A Lettuce, leaf 9.000000 1.000 1.000 0401248000 4A Parsley, leaves 9.000000 1.000 1.000 0401313000 4A Radicchio 9.000000 1.000 1.000 0401355000 4A Spinach 9.000000 1.000 1.000 0401355001 4A Spinach - babyfood 9.00000 0 1.000 1.000 0402076000 4B Cardoon 9.000000 1.000 1.000 0402085000 4B Celery 9.000000 1.000 1.000 0402085001 4B Celery - babyfood 9.000000 1.000 1.000 040208 6000 4B Celery, juice 9.000000 1.000 1.000

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 10 of 25 0402087000 4B Celtuce 9.000000 1.000 1.000 0402152000 4B Fennel, Florence 9.000000 1.000 1.000 0402322000 4B Rhubarb 9.000000 1.000 1.000 0402367000 4B Swiss chard 9.000000 1.000 1.000 0501061000 5A Broccoli 2.500000 1.000 1.000 0501061001 5A Broccoli - babyfood 2.500000 1.000 1.000 0501062000 5A Broccoli, Chinese 2.500000 1.000 1.000 0501064000 5A Brussels sprouts 2.500000 1.000 1.000 0501069000 5A Cabbage 2.500000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 2.500000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 2.500000 1.000 1.000 0501083000 5A Cauliflower 2.500000 1.000 1.000 0501196000 5A Kohlrabi 2.500000 1.000 1.000 0502063000 5B Broccoli raab 8.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 8.000000 1.000 1.000 0502117000 5B Collard s 8.000000 1.000 1.000 0502194000 5B Kale 8.000000 1.000 1.000 0502229000 5B Mustard greens 8.000000 1.000 1.000 0502318000 5B Rape greens 8.000000 1.000 1.000 0502389000 5B Turnip, greens 8.000000 1.000 1.000 0600347000 6 Soybean, seed 5.000000 1.000 1.000 0600349000 6 Soybean, soy milk 5.000000 1.000 1.00 0 0600349001 6 Soybean, soy milk - babyfood or in 5.000000 1.000 1.000 0600350000 6 Soybean, oil 5.000000 1.000 1.000 0600350001 6 Soybean, oil - babyfood 5.000000 1.000 1.000 0601043000 6A Bean, snap, succulent 2.500000 1.000 1.000 0601043001 6A Bean, snap, succulent - babyfood 2.500000 1.000 1.000 0601257000 6A Pea, edible podded, succulent 2.500000 1.000 1.000 0601349500 6AB Soybean, vegetable 5.000000 1.000 1.000 0602031000 6B Bean, broad, succulent 2.500000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 2.500000 1.000 1.000 0602037000 6B Bean, lima, succulent 2.500000 1.000 1.000 0602255000 6B Pea, succulent 2.500000 1.000 1.000 0602255001 6B Pea, succulent - babyfood 2.500000 1.000 1.000 0602259000 6B Pea, pigeon, succulent 2.500000 1.000 1.000 0603030000 6C B ean, black, seed 2.500000 1.000 1.000 0603032000 6C Bean, broad, seed 2.500000 1.000 1.000 0603034000 6C Bean, cowpea, seed 2.500000 1.000 1.000 0603035000 6C Bean, great northern, see d 2.500000 1.000 1.000 0603036000 6C Bean, kidney, seed 2.500000 1.000 1.000 0603038000 6C Bean, lima, seed 2.500000 1.000 1.000 0603039000 6C Bean, mung, seed 2.500000 1.000 1.000 0603040000 6C Bean, navy, seed 2.500000 1.000 1.000 0603041000 6C Bean, pink, seed 2.500000 1.000 1.000 0603042000 6C Bean, pinto, seed 2.500000 1.000 1.000 0603098000 6C Chickpea, seed 2.500000 1.000 1.000 0603098001 6C Chickpea, seed - babyfood 2.500000 1.000 1.000 0603099000 6C Chickpea, flour 2.500000 1.000 1.000 0603182000 6C Guar, seed 2.500000 1.000 1.000 0603182001 6C Guar, seed - babyfood 2.500000 1.000 1.000 0603203000 6C Lentil, seed 2.500000 1.000 1.000 0603256000 6C Pea, dry 2.500000 1.0 00 1.000 0603256001 6C Pea, dry - babyfood 2.500000 1.000 1.000 0603258000 6C Pea, pigeon, seed 2.500000 1.000 1.000 0603348000 6C Soybean, flour 5.000000 1.000 1.000 0603348001 6C Soybean, flour - babyfood 5.000000 1.000 1.000 0801374000 8A Tomatillo 2.500000 1.000 1.000 0801375000 8A Tomato 2.500000 1.000 1.000 0801375001 8A Tomato - babyfood 2.500000 1.000 1.000 0801376000 8A Tomato, paste 2.500000 5.400 1.000 0801376001 8A Tomato, paste - babyfood 2.500000 5.400 1.000 0801377000 8A Tomato, puree 2.500000 3.300 1.000 0801377001 8A Tomato, puree - babyfood 2.500000 3.300 1.000 0801378000 8A Tomato, dried 2.500000 14.300 1.000 0801378001 8A Tomato, dried - babyfood 2.500000 14.300 1.000 0801379000 8A Tomato, juice 2.500000 1.500 1.000 0801380000 8A Tomato, Tree 2.500000 1.000 1.000

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 11 of 2 5 0802148000 8BC Eggplant 2.500000 1.000 1.000 0802234000 8BC Okra 2.500000 1.000 1.000 0802270000 8B Pepper, bell 2.500000 1.000 1.000 0802270001 8B Pepper, bell - babyfood 2.500000 1.000 1.000 0802271000 8B Pepper, bell, dried 2.500000 1.000 1.000 0802271001 8B Pepper, bell, dried - babyfood 2.500000 1.000 1.000 0802272000 8BC Pepper, nonbell 2.500000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 2.500000 1.000 1.000 08022730 00 8BC Pepper, nonbell, dried 2.500000 1.000 1.000 0901075000 9A Cantaloupe 0.300000 1.000 1.000 0901187000 9A Honeydew melon 0.300000 1.000 1.000 0901399000 9A Watermelon 0.300000 1.000 1.000 0901400000 9A Watermelon, juice 0.300000 1.000 1.000 0902021000 9B Balsam pear 0.300000 1.000 1.000 0902088000 9B Chayote, fruit 0.30000 0 1.000 1.000 0902102000 9B Chinese waxgourd 0.300000 1.000 1.000 0902135000 9B Cucumber 0.300000 1.000 1.000 0902308000 9B Pumpkin 0.300000 1.000 1.000 090230 9000 9B Pumpkin, seed 0.300000 1.000 1.000 0902356000 9B Squash, summer 0.300000 1.000 1.000 0902356001 9B Squash, summer - babyfood 0.300000 1.000 1.000 0902357000 9B Squash, winter 0.300000 1.000 1.000 0902357001 9B Squash, winter - babyfood 0.300000 1.000 1.000 1001106000 10A Citron 0.600000 1.000 1.000 1001107000 10A Citrus hybrids 0.600000 1.000 1.000 1001108000 10A Citrus, oil 6.000000 1.000 1.000 1001240000 10A Orange 0.600000 1.000 1.000 1001241000 10A Orange, juice 0.600000 1.800 1.000 1001241001 10A Orange, juice - babyfood 0.600000 1.800 1.000 1001242000 10A Orange, peel 0.600000 1.000 1.000 1001369000 10A Tangerine 0.600000 1.000 1.0 00 1001370000 10A Tangerine, juice 0.600000 2.300 1.000 1002197000 10B Kumquat 0.600000 1.000 1.000 1002199000 10B Lemon 0.600000 1.000 1.000 1002200000 10B Lemo n, juice 0.600000 2.000 1.000 1002200001 10B Lemon, juice - babyfood 0.600000 2.000 1.000 1002201000 10B Lemon, peel 0.600000 1.000 1.000 1002206000 10B Lime 0.600000 1.000 1.000 1002207000 10B Lime, juice 0.600000 2.000 1.000 1002207001 10B Lime, juice - babyfood 0.600000 2.000 1.000 1003180000 10C Grapefruit 0.600000 1.000 1 .000 1003181000 10C Grapefruit, juice 0.600000 2.100 1.000 1003307000 10C Pummelo 0.600000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.700000 1.000 1.000 1100008000 11 Ap ple, peeled fruit 0.700000 1.000 1.000 1100008001 11 Apple, peeled fruit - babyfood 0.700000 1.000 1.000 1100009000 11 Apple, dried 0.700000 8.000 1.000 1100009001 11 Apple, dried - babyfood 0.700000 8.000 1.000 1100010000 11 Apple, juice 0.700000 1.300 1.000 1100010001 11 Apple, juice - babyfood 0.700000 1.300 1.000 1100011000 11 Apple, sauce 0.700000 1.000 1.000 1100011001 11 Apple, sauce - babyfood 0.700000 1.000 1.000 1100129000 11 Crabapple 0.700000 1.000 1.000 1100173500 11 Goji berry 2.500000 1.000 1.000 1100210000 11 Loquat 0.700000 1.000 1.000 1100266000 11 Pear 0.700000 1.000 1.000 1100266001 11 Pear - babyfood 0.700000 1.000 1.000 1100267000 11 Pear, dri ed 0.700000 6.250 1.000 1100268000 11 Pear, juice 0.700000 1.000 1.000 1100268001 11 Pear, juice - babyfood 0.700000 1.000 1.000 1100310000 11 Quince 0.700000 1.000 1.000 1201090000 12A Cherry 4.500000 1.000 1.000 1201090001 12A Cherry - babyfood 4.500000 1.000 1.000 1201091000 12A Cherry, juice 4.500000 1.500 1.000 1201091001 12A Cherry, juice - babyfood 4.500000 1.500 1.000 1202012000 12B Apricot 4.500000 1.000 1.000 1202012001 12B Apricot - babyfood 4.500000 1.000 1.000

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 12 of 25 1202013000 12B Apricot , dried 4.500000 6.000 1.000 1202014000 12B Apricot, juice 4.500000 1.000 1.000 1202014001 12B Apricot, juice - babyfood 4.500000 1.000 1.000 1202230000 12B Nectarine 4.500000 1.000 1.000 1202260000 12B Peach 4.500000 1.000 1.000 1202260001 12B Peach - babyfood 4.500000 1.000 1.000 1202261000 12B Peach, dried 4.500000 7.000 1.00 0 1202261001 12B Peach, dried - babyfood 4.500000 7.000 1.000 1202262000 12B Peach, juice 4.500000 1.000 1.000 1202262001 12B Peach, juice - babyfood 4.500000 1.000 1.000 1203285000 12C Plum 4.500000 1.000 1.000 1203285001 12C Plum - babyfood 4.500000 1.000 1.000 1203286000 12C Plum, prune, fresh 4.500000 1.000 1.000 1203286001 12C Plum, prune, fresh - babyfood 4.500000 1.000 1.000 1203287000 12C Plum, prune, dried 4.500000 5.000 1.000 1203287001 12C Plum, prune, dried - babyfood 4.500000 5.000 1.000 1203288000 12C Plum, prune, juice 4.500000 1.400 1.000 1203288001 12C Plum, prune, juice - babyfood 4.500000 1.400 1.000 1302057000 13B Blueberry 3.000000 1.000 1.000 1302057001 13B Blueberry - babyfood 3.000000 1.000 1.000 1302136000 13B Currant 3.000000 1.000 1.000 1302137000 13B Currant, dried 3.000000 1.000 1.000 1302149000 13B Elderberry 3.000000 1.000 1.000 1302174000 13B Gooseberry 3.000000 1.000 1.000 1302191000 13B Huckleberry 3.000000 1.000 1.000 1304175000 13D Grape 1.300000 1.000 1.000 1304176000 13D Grape, juice 1.300000 1.20 0 1.000 1304176001 13D Grape, juice - babyfood 1.300000 1.200 1.000 1304179000 13D Grape, wine and sherry 1.300000 1.000 1.000 1304195000 13D Kiwifruit, fuzzy 1.300000 1.000 1.000 1307130000 13G Cranberry 0.300000 1.000 1.000 1307130001 13G Cranberry - babyfood 0.300000 1.000 1.000 1307131000 13G Cranberry, dried 0.300000 1.000 1.000 1307132000 13G Cranberry, juice 0.300000 1.100 1.000 1307132001 13G Cranberry, juice - babyfood 0.300000 1.100 1.000 1307359000 13G Strawberry 0.400000 1.000 1.000 1307359001 13G Strawberry - babyfood 0.400000 1. 000 1.000 1307360000 13G Strawberry, juice 0.400000 1.000 1.000 1307360001 13G Strawberry, juice - babyfood 0.400000 1.000 1.000 1400003000 14 Almond 0.250000 1.000 1.000 1400003001 1 4 Almond - babyfood 0.250000 1.000 1.000 1400004000 14 Almond, oil 0.250000 1.000 1.000 1400004001 14 Almond, oil - babyfood 0.250000 1.000 1.000 1400059000 14 Brazil nut 0.250000 1.000 1.000 1400068000 14 Butternut 0.250000 1.000 1.000 1400081000 14 Cashew 0.250000 1.000 1.000 1400092000 14 Chestnut 0.250000 1.000 1.000 1400155000 14 Hazelnut 0.250000 1.000 1.000 1400156000 14 Hazelnut, oil 0.250000 1.000 1.000 1400185000 14 Hickory nut 0.250000 1.000 1.000 1400213000 14 Macadamia nut 0.250000 1.000 1.000 1400269000 14 Pecan 0.250000 1.000 1.000 1400282000 14 Pistachio 0.250000 1.000 1.000 1400391000 14 Walnut 0.250000 1.000 1.000 1500127000 15 Corn, sweet 1.500000 1.000 1.000 1500127001 15 Corn, sweet - babyfood 1.500000 1.000 1.000 2003128000 20C Cottons eed, oil 0.300000 1.000 1.000 2003128001 20C Cottonseed, oil - babyfood 0.300000 1.000 1.000 3100044000 31 Beef, meat 0.020000 1.000 1.000 3100044001 31 Beef, meat - babyfood 0.020000 1.000 1.000 3100045000 31 Beef, meat, dried 0.020000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 3100046001 31 Beef, meat byproducts - babyfood 0.200000 1.000 1.00 0 3100047000 31 Beef, fat 0.020000 1.000 1.000 3100047001 31 Beef, fat - babyfood 0.020000 1.000 1.000 3100048000 31 Beef, kidney 0.200000 1.000 1.000 3100049000 31 Beef, liver 0.200000 1.000 1.000

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 13 of 25 3100049001 31 Beef, liver - babyfood 0.200000 1.000 1.000 3200169000 32 Goat, meat 0.020000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 3200171000 32 Goat, fat 0.020000 1.000 1.000 3200172000 32 Goat, kidney 0.200000 1.000 1.000 3200173000 32 Goat, liver 0.200000 1.000 1.000 3300189000 33 Horse, meat 0.020000 1.000 1.000 3400291000 34 Pork, skin 0.020000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.020000 1.000 1.000 3400292001 34 P ork, meat byproducts - babyfood 0.020000 1.000 1.000 3400294000 34 Pork, kidney 0.020000 1.000 1.000 3400295000 34 Pork, liver 0.020000 1.000 1.000 3500339000 35 Sheep, meat 0.020000 1.000 1.000 3500339001 35 Sheep, meat - babyfood 0.020000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 3500341000 35 Sheep, fat 0.020000 1.000 1.000 3500341001 35 Sheep, fat - babyfood 0.020000 1.000 1.000 3500342000 35 Sheep, kidney 0.200000 1.000 1.000 3500343000 35 Sheep, liver 0.200000 1.000 1.000 3600222000 36 Milk, fat 0.010000 1.000 1.000 3600222001 36 Milk, fat - baby food/infant formu 0.010000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.010000 1.000 1.000 3600223001 36 Milk, nonfat solids - baby food/in 0.010000 1.000 1.000 3600224000 36 Milk, water 0.010000 1.000 1.000 3600224001 36 Milk, water - babyfood/infant form 0.010000 1.000 1.000 3600225001 36 Milk, sugar (lactose) - baby food/ 0.010000 1.0 00 1.000 3800221000 38 Meat, game 0.020000 1.000 1.000 4000094000 40 Chicken, liver 0.020000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.020000 1.000 1.000 4000095001 40 Chicken, meat byproducts - babyfoo 0.020000 1.000 1.000 4000097000 40 Chicken, skin 0.020000 1.000 1.000 4000097001 40 Chicken, skin - babyfood 0.020000 1.000 1.000 5000383000 50 Turkey, liver 0.020000 1.000 1.000 5000383001 50 Turkey, liver - babyfood 0.020000 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.020000 1.000 1.000 5000384001 50 Turkey, meat byproducts - babyfood 0.020000 1.000 1.000 5000386000 50 Turkey, skin 0.020000 1.000 1.000 5000386001 50 Turkey, skin - babyfood 0.020000 1.000 1.000 6000302000 60 Poultry, other, liver 0.020000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.020000 1.000 1.000 6000305000 60 Poultry, other, skin 0.020000 1.000 1.000 7000145000 70 Egg, whole 0.020000 1.000 1.000 7000145001 70 Egg, whole - babyfood 0.020000 1.000 1.000 7000146000 70 Egg, white 0.020000 1.000 1.000 7000146001 70 Egg, white (solids) - babyfood 0.020000 1.000 1.000 7000147000 70 Egg, yolk 0.020000 1.000 1.000 7000147001 70 Egg, yolk - babyfood 0.020000 1.000 1.000 8601000000 86A Water, direct, all sources 0.395000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.395000 1.000 1.000 95000010 00 O Acerola 2.500000 1.000 1.000 9500016000 O Artichoke, globe 1.500000 1.000 1.000 9500020000 O Avocado 0.600000 1.000 1.000 9500023000 O Banana 4.000000 1.000 1.000 9500023001 O Banana - babyfood 4.000000 1.000 1.000 9500024000 O Banana, dried 4.000000 3.900 1.000 9500024001 O Banana, dried - babyfood 4.00000 0 3.900 1.000 9500074000 O Canistel 0.600000 1.000 1.000 9500115000 O Coffee, roasted bean 0.200000 1.000 1.000 9500116000 O Coffee, instant 0.500000 1.000 1.000 950015 1000 O Feijoa 2.500000 1.000 1.000 9500177000 O Grape, leaves 1.300000 1.000 1.000 9500178000 O Grape, raisin 3.000000 1.000 1.000 9500183000 O Guava 2.500000 1.000 1.000 9500183001 O Guava - babyfood 2.500000 1.000 1.000 9500188000 O Hop 10.000000 1.000 1.000 9500209000 O Longan 13.000000 1.000 1.000 9500211000 O Lychee 13.000000 1.000 1.000

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 14 of 25 9500212000 O Lychee, dried 13.000000 1.850 1.000 9500215000 O Mango 0.600000 1.000 1.000 9500215001 O Mango - babyfood 0.600000 1.000 1.000 9500216000 O Mango, dried 0.600000 1.000 1.000 9500217000 O Mango, juice 0.600000 1.000 1.000 9500217001 O Mango, juice - babyfood 0.600000 1.000 1.000 9500245000 O Papaya 2.500000 1.000 1.000 9500245001 O Papaya - babyfood 2.500000 1.000 1.000 9500246000 O Papaya, dried 2.500000 1.800 1.000 9500247000 O Papaya, juice 2.500000 1.500 1.000 9500252000 O Passionfruit 2.500000 1.000 1.000 9500252001 O Passionfruit - babyfood 2.500000 1.000 1.000 9500253000 O Passionfruit, juice 2.500000 1.000 1.000 9500253001 O Passionfruit, juice - babyfood 2.500000 1.000 1.000 9500277000 O Persimmon 2.500000 1.000 1.00 0 9500279000 O Pineapple 0.300000 1.000 1.000 9500279001 O Pineapple - babyfood 0.300000 1.000 1.000 9500280000 O Pineapple, dried 0.300000 5.000 1.000 9500281000 O Pinea pple, juice 0.300000 1.700 1.000 9500281001 O Pineapple, juice - babyfood 0.300000 1.700 1.000 9500283000 O Plantain 4.000000 1.000 1.000 9500284000 O Plantain, dried 4.000000 3.900 1.000 9500289000 O Pomegranate 0.500000 1.000 1.000 9500333000 O Sapote, Mamey 0.600000 1.000 1.000 9500351000 O Spanish lime 13.000000 1.000 1.000 9500358000 O Starfruit 2.500000 1.000 1.000 9500398000 O Watercress 2.000000 1.000 1.000

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 15 of 25 

## Attachment 2: Acute Results File U.S. EPA Ver. 3.16, 03 - 08 - d DEEM - FCID ACUTE Analysis for SPIROTETRAMAT NHANES 2003 - 2008 2 - Day Residue file: updated SPIROTETRAMAT__ACUTE__21 Dec 2012.R08 Adjustment factor #2 used. Analysis Date: 12 - 21 - 2012/13:26:05 Residue file dated : 12 - 21 - 2012/11:35:33 RAC/FF intake summed over 24 hours Run Comment: "+ emp proc fact"

=============================================================================== Summary calculations -- per capita: 95th Percentile 99th Percent ile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Population: 0.066115 6.61 0.114460 11.45 0.209645 20.96 All Infants: 0.137642 13.76 0.220433 22.04 0.419080 41.91 Children 1 - 2: 0.155241 15.52 0.282877 28.29 0.447 437 44.74 Children 3 - 5: 0.125606 12.56 0.181399 18.14 0.276584 27.66 Children 6 - 12: 0.075624 7.56 0.115439 11.54 0.186328 18.63 Youth 13 - 19: 0.046354 4.64 0.071801 7.18 0.117196 11.72 Adults 20 - 49: 0.053000 5.30 0.075334 7.53 0.118274 11.83 Adults 50 - 99: 0.050326 5.03 0.074209 7.42 0.107443 10.74 Female 13 - 49: 0.052999 5.30 0.078727 7.87 0.118210 11.82

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 16 of 25 

## Attachment 3: Average Field Trial Residues and Processing Factors Used in the Chronic Assessment **Table A. 3**  **. Summary of Residues and Processing Factors used in the Chronic Assessment 1**  **.**

**Crop Commodity**  **Residue (ppm)**  **Processing**

**Factor %CT**  **Comments**

Potato and Sweet Potato RAC 0.171 1 100 Potato residues translated to sweet potato using HED SOP 2000.1. Other members of crop group 1C used tolerance - level residues. Future assessments could incorporate average field - trial (FT) residues for these commodities. Average FT residue. Used 150 OD formulation because had highest average residue. Memo, G. Kramer, 17 - AP R- 2008; D339694. Dried 1.6 1 100 Tolerance - level residue. Processing factor set to 1 because separate tolerance established in 40 CFR §180.641. Onion RAC 0.80 1 100 HED - recommended tolerance - level residue. Dried 0.80 9.0 100 HED - recommended tolerance - level residue. DEEM 7.81 default processing factor. Head Lettuce RAC 0.605 1 100 Average FT residue. Used 100 OD formulation because had highest average residue. Memo, G. Kramer, 17 - AP R- 2008; D339694. Leaf Lettuce RAC 0.882 1 100 Average FT residue. Used 100 OD formulation because had highest average residue. Memo, G. Kramer, 17 - AP R- 2008; D339694. Spinach RAC 2.496 1 100 Average FT residue. Used 240 SC formulation because had highest average residue. Memo, G. Kramer, 17 - AP R- 2008; D339694. Edible -podded beans (6A) RAC 0.444 1 100 Average snap bean FT residue. Used OD formulation because had highest average residue. Memo, G. Kramer, 23 - DEC - 2010; D362952. Edible -podded peas (6A) RAC 1.28 1 100 Average snow pea FT residue. Used SC formulation because had highest average residue. Memo, G. Kramer, 23 - DEC - 2010; D362952. Succulent shelled beans (6B) RAC 0.243 1 100 Average lima bean FT residue. Used OD formulation because had highest average residue. Memo, G. Kramer, 23 - DEC - 2010; D362952. Succulent shelled peas (6B) RAC 0.583 1 100 Average garden pea FT residue. Used OD formulation because had highest average residue. Memo, G. Kramer, 23 - DEC - 2010; D362952.

To mato RAC 2.5 1 100 Tolerance - level residue. Dried 2.5 12 100 Tolerance - level residue. Empirical processing factor from Memo, G. Kramer, 17 - AP R- 2008; D339694. Juice 2.5 0.9 100 Tolerance - level residue. Empirical processing factor from Memo, G. Kramer, 17 - AP R- 2008; D339694. Paste 2.5 1 100 Tolerance - level residue. Processing factor set to 1 because a separate tolerance was not required based on the available processing data and the tolerance - level values were used in the assessment (Memo, G. Kramer, 17 - AP R- 2008; D339694). Puree 2.5 1 100 Tolerance - level residue. Processing factor set to 1 because a separate tolerance was not required based on the available processing data and the tolerance - level values were used in the assessment (Memo, G. Kramer, 17 - AP R- 2008; D339694). Grapefruit RAC 0.60 1 100 Tolerance - level residue. Juice 0.60 2.1 100 Tolerance - level residue. DEEM 7.81 default processing factor.

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 17 of 25 **Table A. 3**  **. Summary of Residues and Processing Factors used in the Chronic Assessment 1**  **.**

**Crop Commodity**  **Residue (ppm)**  **Processing**

**Factor %CT**  **Comments** Lemon RAC 0.60 1 100 Tolerance - level residue. Juice 0.60 2.0 100 Tolerance - level residue. DEEM 7.81 default processing factor. Lime RAC 0.60 1 100 Tolerance - level residue. Juice 0.60 2.0 100 Tolerance - level residue. DEEM 7.81 default processing factor. Orange RAC 0.60 1 100 Tolerance - level residue. Juice 0.60 0.4 100 Tolerance - level residue. Empirical processing factor from Memo, G. Kramer, 17 - AP R- 2008; D339694. Tangerine RAC 0.60 1 100 Tolerance - level residue. Juice 0.60 2.3 100 Tolerance - level residue. DEEM 7.81 default processing factor. Apple RAC 0.152 1 100 Average FT residue. Used concentrated 150 OD formulation because had highest average residue. Memo, G. Kramer, 17 - AP R- 2008; D339694. Dried 0.152 1 100 Average FT residue. Empirical processing factor from Memo, G. Kramer, 17 - AP R- 2008; D339694. Juice 0.152 0.4 100 Average FT residue. Empirical processing factor from Memo, G. Kramer, 17 - AP R- 2008; D339694. Sauce 0.152 0.1 100 Average FT residue. Empirical processing factor from Memo, G. Kramer, 17 - AP R- 2008; D339694. Pear RAC 0.205 1 100 Average FT residue. Used concentrated 150 OD formulation because had highest average residue. Memo, G. Kramer, 17 - AP R- 2008; D339694. Dried 0.205 6.25 100 Average FT residue. DEEM 7.81 default processing factor. Juice 0.205 1 100 Average FT residue. Apricot RAC 4.50 1 100 Tolerance - level residue. Dried 4.50 6.0 100 Tolerance - level residue. DEEM 7.81 default processing factor. Juice 4.50 1 100 Tolerance - level residue. Cherry RAC 1.480 1 100 Average FT residue. Used dilute 150 OD formulation because had highest average residue. Memo, G. Kramer, 17 - AP R- 2008; D339694. Juice 1.480 1.5 100 Average FT residue. DEEM 7.81 default processing factor. Peach RAC 0.692 1 100 Average FT residue. Used dilute 150 OD formulation because had highest average residue. Memo, G. Kramer, 17 - AP R- 2008; D339694. Dried 0.692 7.0 100 Average FT residue. DEEM 7.81 default processing factor. Juice 0.692 1 100 Average FT residue. RAC 4.5 1 100 Tolerance - level residue. Plum, prune Dried 4.5 1 100 Tolerance - level residue. Processing factor set to 1 because a separate tolerance was not required based on the available processing data and the tolerance - level values were used in the assessment (Memo, G. Kramer, 17 - AP R- 2008; D339694). Juice 4.5 1.4 100 Tolerance - level residue. DEEM 7.81 default processing factor.

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 18 of 25 **Table A. 3**  **. Summary of Residues and Processing Factors used in the Chronic Assessment 1**  **.**

**Crop Commodity**  **Residue (ppm)**  **Processing**

**Factor %CT**  **Comments** Cranberry RAC 0.30 1 100 HED - recommended tolerance - level residue. Juice 0.30 1.1 100 HED - recommended tolerance - level residue. DEEM 7.81 default processing factor. Grape RAC 0.412 1 100 Average FT residue. Used OD formulation because had highest average residue. Memo, G. Kramer, 17 - AP R- 2008; D339694. Juice 0.412 0.66 100 Average FT residue. Empirical processing factor from Memo, G. Kramer, 17 - AP R- 2008; D339694. Raisin 3.0 1 100 Tolerance - level residue. Processing factor set to 1 because separate tolerance established in 40 CFR §180.641. Beef, meat Dried 0.02 1.92 100 Tolerance - level residue. DEEM 7.81 default processing factor. Banana and plantain RAC 1.3 1 100 Average FT residue from Memo, G. Kramer, 26 - MAR- 2013 ; D398856. Dried 1.3 3.9 100 Average FT residue. DEEM 7.81 default processing factor. Feijoa RAC 2.5 1 100 This tolerance is incorrect in the 40CFR. Since the HED - recommended tolerance of 2.5 ppm (Memo, J. Van Alstine et al. , 22 - DEC - 2010; D368785) is greater than the tolerance in the 40 CFR, the higher HED - recommended tolerance has been used. Lychee, dried RAC 13.0 1 100 Tolerance - level residue. Dried 13.0 1.85 100 Tolerance - level residue. DEEM 7.81 default processing factor. Papaya RAC 2.5 1 100 Tolerance - level residue, as included 40CFR. Although the HED - recommended tolerance is 0.35 ppm, 2.5 ppm was used to be conservative. HED has notified RD that the tolerance should be updated to reflect the HED - recommended tolerance of 0.35 ppm. DEEM 7.81 default processing factor. Dried 2.5 1.8 100 Tolerance - level residue, as included 40CFR. DEEM 7.81 default processing factor. Juice 2.5 1.5 100 Tolerance - level residue, as included 40CFR. DEEM 7.81 default processing factor. Persimmon RAC 2.5 1 100 This tolerance was recommended in Memo, J. Van Alstine et al ., 22 - DEC - 2010 (D368785), however it was excluded from the 40CFR. It has been included in the assessment since a tolerance was recommended. Pineapple RAC 0.30 1 100 HED - recommended tolerance - level residue. Dried 0.30 5.0 100 HED - recommended tolerance - level residue. DEEM 7.81 default processing factor. Juice 0.30 0.72 100 HED - recommended tolerance - level residue. Empirical processing factor from Memo, G. Kramer, 26 - MAR- 2013 ; D398856. Spanish lime RAC 13.0 1 100 This tolerance is incorrect in the 40CFR. Since the HED - recommended tolerance of 13.0 ppm (Memo, J. Van Alstine et al. , 22 - DEC - 2010; D368785) is greater than the tolerance in the 40 CFR, the higher HED - recommended tolerance has been used. 1 Tolerance - level residues were assumed for the remaining commodities with tolerances that are not included in this table.

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 19 of 25 

## Attachment **4 : Chronic Food plus Water Residue Input File**  Filename: C: \ Documents and Settings \ jlangsda \ My Documents \ Chemicals \ Spiro tetramat \ 2012 RCC \ Dietary \ Sent to Reviewers \ updated to include Kiwi \ updated SPIROTETRAMAT__CHRONIC__21 Dec 2012.R08 Chemical: Spirotetramat RfD(Chronic): .05 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 0 mg/kg bw /day Date created/last modified: 12 - 21 - 2012/11:38:57 Program ver. 3.16, 03 - 08 - d

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0103015000 1CD Arrowroot, flour 0.600000 1.000 1.000 0103015001 1CD Arrowr oot, flour - babyfood 0.600000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.600000 1.000 1.000 0103082000 1CD Cassava 0.600000 1.000 1.000 0103082001 1CD Cassava - babyfood 0.600000 1.000 1.000 0103139000 1CD Dasheen, corm 0.600000 1.000 1.000 0103166000 1CD Ginger 0.600000 1.000 1.000 0103166001 1CD Ginger - babyfood 0.600000 1.000 1.0 00 0103167000 1CD Ginger, dried 0.600000 1.000 1.000 0103296000 1C Potato, chips 0.171000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 1.600000 1.000 1.000 0103297001 1C Pota to, dry (granules/ flakes) - b 1.600000 1.000 1.000 0103298000 1C Potato, flour 1.600000 1.000 1.000 0103298001 1C Potato, flour - babyfood 1.600000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.171000 1.000 1.000 0103299001 1C Potato, tuber, w/peel - babyfood 0.171000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.171000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel - babyfood 0.171000 1.000 1 .000 0103366000 1CD Sweet potato 0.171000 1.000 1.000 0103366001 1CD Sweet potato - babyfood 0.171000 1.000 1.000 0103371000 1CD Tanier, corm 0.600000 1.000 1.000 0103387000 1CD Turmeric 0.600000 1.000 1.000 0103406000 1CD Yam, true 0.600000 1.000 1.000 0103407000 1CD Yam bean 0.600000 1.000 1.000 0301165000 3A Garlic, bulb 0.800000 1.000 1.000 0301165001 3A Garlic, bulb - babyfood 0.800000 1.000 1.000 0301237000 3A Onion, bulb 0.800000 1.000 1.000 0301237001 3A Onion, bulb - babyfood 0.800000 1.00 0 1.000 0301238000 3A Onion, bulb, dried 0.800000 9.000 1.000 0301238001 3A Onion, bulb, dried - babyfood 0.800000 9.000 1.000 0301338000 3A Shallot, bulb 0.800000 1.000 1.000 0302103000 3B Chive, fresh leaves 0.800000 1.000 1.000 0302198000 3B Leek 0.800000 1.000 1.000 0302239000 3B Onion, green 0.800000 1.000 1.000 0302338500 3B Shallot, fresh leaves 0.800000 1.000 1.000 0401005000 4A Amaranth, leafy 9.000000 1.000 1.000 0401018000 4A Arugula 9.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 9.000000 1. 000 1.000 0401133000 4A Cress, garden 9.000000 1.000 1.000 0401134000 4A Cress, upland 9.000000 1.000 1.000 0401138000 4A Dandelion, leaves 9.000000 1.000 1.000 0401150000 4 A Endive 9.000000 1.000 1.000 0401204000 4A Lettuce, head 0.605000 1.000 1.000 0401205000 4A Lettuce, leaf 0.882000 1.000 1.000 0401248000 4A Parsley, leaves 9.000000 1.000 1.000 0401313000 4A Radicchio 9.000000 1.000 1.000 0401355000 4A Spinach 2.496000 1.000 1.000 0401355001 4A Spinach - babyfood 2.496000 1.000 1.000 0402076000 4B Cardoon 9.000000 1.000 1.000 0402085000 4B Celery 9.000000 1.000 1.000 0402085001 4B Celery - babyfood 9.000000 1.000 1.000 0402086000 4B Celery, juice 9.000000 1.000 1.000 0402087000 4B Celtuce 9.000000 1.000 1.000

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 20 of 25 0402152000 4B Fennel, Florence 9.000000 1.000 1.000 0402322000 4B Rhubarb 9.000000 1.000 1.000 0402367000 4B Swiss chard 9.000000 1.000 1.000 0501061000 5A Broccoli 2.500000 1.000 1.000 0501061001 5A Broccoli - babyfood 2.500000 1.000 1.000 0501062000 5A Broccoli, Chinese 2.500000 1.000 1.000 0501064000 5A Brussels sprouts 2.500000 1.000 1.000 0501069000 5A Cabbage 2.500000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 2.500000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 2.500000 1.000 1.000 0501083000 5A Cauliflower 2.500000 1.000 1.000 0501196000 5A Kohlrab i 2.500000 1.000 1.000 0502063000 5B Broccoli raab 8.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 8.000000 1.000 1.000 0502117000 5B Collards 8.000000 1.000 1.000 0502194000 5B Kale 8.000000 1.000 1.000 0502229000 5B Mustard greens 8.000000 1.000 1.000 0502318000 5B Rape greens 8.000000 1.000 1.00 0 0502389000 5B Turnip, greens 8.000000 1.000 1.000 0600347000 6 Soybean, seed 5.000000 1.000 1.000 0600349000 6 Soybean, soy milk 5.000000 1.000 1.000 0600349001 6 Soybe an, soy milk - babyfood or in 5.000000 1.000 1.000 0600350000 6 Soybean, oil 5.000000 1.000 1.000 0600350001 6 Soybean, oil - babyfood 5.000000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.444000 1.000 1.000 0601043001 6A Bean, snap, succulent - babyfood 0.444000 1.000 1.000 0601257000 6A Pea, edible podded, succulent 1.280000 1.000 1.000 0601349500 6AB Soybean, vegetable 5.000000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.243000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.243000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.243000 1.000 1.000 0602255000 6B P ea, succulent 0.583000 1.000 1.000 0602255001 6B Pea, succulent - babyfood 0.583000 1.000 1.000 0602259000 6B Pea, pigeon, succulent 0.583000 1.000 1.000 0603030000 6C Bean, black, seed 2.500000 1.000 1.000 0603032000 6C Bean, broad, seed 2.500000 1.000 1.000 0603034000 6C Bean, cowpea, seed 2.500000 1.000 1.000 0603035000 6C Bean, great northern, seed 2.500000 1.000 1.000 0603036000 6C Bean, kidney, seed 2.500000 1.000 1.000 0603038000 6C Bean, lima, seed 2.500000 1.000 1.000 0603039000 6C Bean, mung, seed 2.500000 1.000 1.000 0603040000 6C Bean, navy, seed 2.500000 1.000 1.000 0603041000 6C Bean, pink, seed 2.500000 1.000 1.000 0603042000 6C Bean, pinto, seed 2.500000 1.000 1.000 0603098000 6C Chickpea, seed 2.500000 1.000 1.000 0603098001 6C Chickpea, seed - babyfood 2.500000 1.000 1.000 0603099000 6C Chickpea, flour 2.500000 1.000 1.000 0603182000 6C Guar, seed 2.500000 1.0 00 1.000 0603182001 6C Guar, seed - babyfood 2.500000 1.000 1.000 0603203000 6C Lentil, seed 2.500000 1.000 1.000 0603256000 6C Pea, dry 2.500000 1.000 1.000 0603256001 6C Pea, dry - babyfood 2.500000 1.000 1.000 0603258000 6C Pea, pigeon, seed 2.500000 1.000 1.000 0603348000 6C Soybean, flour 5.000000 1.000 1.000 0603348001 6C Soybean, flour - babyfoo d 5.000000 1.000 1.000 0801374000 8A Tomatillo 2.500000 1.000 1.000 0801375000 8A Tomato 2.500000 1.000 1.000 0801375001 8A Tomato - babyfood 2.500000 1.000 1.000 0801376000 8A Tomato, paste 2.500000 1.000 1.000 0801376001 8A Tomato, paste - babyfood 2.500000 1.000 1.000 0801377000 8A Tomato, puree 2.500000 1.000 1.000 0801377001 8A Tomato, puree - babyfood 2.500000 1.000 1.000 0801378000 8A Tomato, dried 2.500000 12.000 1.000 0801378001 8A Tomato, dried - babyfood 2.500000 12.000 1.000 0801379000 8A Tomato, juice 2.500000 0.900 1.000 0801380000 8A Tomato, Tree 2.500000 1.000 1.000 0802148000 8BC Eggplant 2.500000 1.000 1.000

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 21 of 25 0802234000 8BC Okra 2.500000 1.000 1.000 0802270000 8B Pepper, bell 2.500000 1.000 1.000 0802270001 8B Pepper, bell - babyfood 2.500000 1.000 1.000 0802271000 8B Pepper, bell, dried 2.500000 1.000 1.000 08022710 01 8B Pepper, bell, dried - babyfood 2.500000 1.000 1.000 0802272000 8BC Pepper, nonbell 2.500000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 2.500000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 2.500000 1.000 1.000 0901075000 9A Cantaloupe 0.300000 1.000 1.000 0901187000 9A Honeydew melon 0.300000 1.000 1.000 0901399000 9A Watermelon 0.30000 0 1.000 1.000 0901400000 9A Watermelon, juice 0.300000 1.000 1.000 0902021000 9B Balsam pear 0.300000 1.000 1.000 0902088000 9B Chayote, fruit 0.300000 1.000 1.000 090210 2000 9B Chinese waxgourd 0.300000 1.000 1.000 0902135000 9B Cucumber 0.300000 1.000 1.000 0902308000 9B Pumpkin 0.300000 1.000 1.000 0902309000 9B Pumpkin, seed 0.300000 1.000 1.000 0902356000 9B Squash, summer 0.300000 1.000 1.000 0902356001 9B Squash, summer - babyfood 0.300000 1.000 1.000 0902357000 9B Squash, w inter 0.300000 1.000 1.000 0902357001 9B Squash, winter - babyfood 0.300000 1.000 1.000 1001106000 10A Citron 0.600000 1.000 1.000 1001107000 10A Citrus hybrids 0.600000 1.000 1.000 1001108000 10A Citrus, oil 6.000000 1.000 1.000 1001240000 10A Orange 0.600000 1.000 1.000 1001241000 10A Orange, juice 0.600000 0.400 1.000 1001241001 10A Orange, juice - babyfood 0.600000 0.400 1.000 1001242000 10A Orange, peel 0.600000 1.000 1.000 1001369000 10A Tangerine 0.600000 1.000 1.000 1001370000 10A Tangeri ne, juice 0.600000 2.300 1.000 1002197000 10B Kumquat 0.600000 1.000 1.000 1002199000 10B Lemon 0.600000 1.000 1.000 1002200000 10B Lemon, juice 0.600000 2.000 1.000 1002200001 10B Lemon, juice - babyfood 0.600000 2.000 1.000 1002201000 10B Lemon, peel 0.600000 1.000 1.000 1002206000 10B Lime 0.600000 1.000 1.00 0 1002207000 10B Lime, juice 0.600000 2.000 1.000 1002207001 10B Lime, juice - babyfood 0.600000 2.000 1.000 1003180000 10C Grapefruit 0.600000 1.000 1.000 1003181000 10C Grape fruit, juice 0.600000 2.100 1.000 1003307000 10C Pummelo 0.600000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.152000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.152000 1.000 1.000 1100008001 11 Apple, peeled fruit - babyfood 0.152000 1.000 1.000 1100009000 11 Apple, dried 0.152000 1.000 1.000 1100009001 11 Apple, dried - babyfood 0.152000 1.000 1.000 1100010000 11 Apple, juice 0.152000 0.400 1.000 1100010001 11 Apple, juice - babyfood 0.152000 0.400 1.000 1100011000 11 Apple, sauce 0.152000 0.100 1.000 1100011001 11 Apple, sauce - babyfood 0.152000 0.100 1.000 1100129000 11 Crabapple 0.700000 1.000 1.000 1100173500 11 Goji berry 2.500000 1.000 1.000 1100210000 11 Loquat 0.700000 1.000 1.000 1100266000 11 Pear 0.205000 1.000 1.000 1100266001 11 Pear - babyfood 0.205000 1.000 1.000 1100267000 11 Pear, dried 0.205000 6.250 1.000 1100268000 11 Pear, juice 0.205000 1.000 1.000 1100268001 11 Pear, juice - babyfood 0.205000 1.000 1.000 1100310000 11 Quince 0.700000 1.000 1.000 1201090000 12A Cherry 1.480000 1.000 1.000 1201090001 12A Cherry - babyfood 1.480000 1.000 1.000 1201091000 12A Cherry, juice 1.480000 1.500 1.000 1201091001 12A Cherry, juice - babyfood 1.480000 1.500 1.000 1202012000 12B Apricot 4.500000 1.000 1.000 1202012001 12B Apricot - babyfood 4.500000 1.000 1.000 1202013000 12B Apricot, dried 4.500000 6.0 00 1.000

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 22 of 25 1202014000 12B Apricot, juice 4.500000 1.000 1.000 1202014001 12B Apricot, juice - babyfood 4.500000 1.000 1.000 1202230000 12B Nectarine 4.500000 1.000 1.000 1202260000 12 B Peach 0.692000 1.000 1.000 1202260001 12B Peach - babyfood 0.692000 1.000 1.000 1202261000 12B Peach, dried 0.692000 7.000 1.000 1202261001 12B Peach, dried - babyfood 0.692000 7.000 1.000 1202262000 12B Peach, juice 0.692000 1.000 1.000 1202262001 12B Peach, juice - babyfood 0.692000 1.000 1.000 1203285000 12C Plum 4.500000 1.000 1.000 1203285001 12C Plum - babyfood 4.500000 1.000 1.000 1203286000 12C Plum, prune, fresh 4.500000 1.000 1.000 1203286001 12C Plum, prune, fresh - babyfood 4.500000 1.000 1.000 1203287000 12C Plum, prune, dried 4.500000 1.000 1.000 1203287001 12C Plum, prune, dried - babyfood 4.500000 1.000 1.000 1203288000 12C Plum, prune, juice 4.500000 1.400 1 .000 1203288001 12C Plum, prune, juice - babyfood 4.500000 1.400 1.000 1302057000 13B Blueberry 3.000000 1.000 1.000 1302057001 13B Blueberry - babyfood 3.000000 1.000 1.000 1302136000 13B Cu rrant 3.000000 1.000 1.000 1302137000 13B Currant, dried 3.000000 1.000 1.000 1302149000 13B Elderberry 3.000000 1.000 1.000 1302174000 13B Gooseberry 3.000000 1.000 1.000 1302191000 13B Huckleberry 3.000000 1.000 1.000 1304175000 13D Grape 0.412000 1.000 1.000 1304176000 13D Grape, juice 0.412000 0.660 1.000 1304176001 13D Grape, juice - babyfood 0.412000 0.660 1.000 1304179000 13D Grape, wine and sherry 0.412000 1.000 1.000 1304195000 13D Kiwifruit, fuzzy 1.300000 1.000 1.000 1307130000 13G Cranberry 0.300000 1.000 1.000 1307130001 13G Cranberry - babyfood 0.300000 1.000 1.000 1307131000 13G Cranberry, dried 0.300000 1.000 1.000 1307132000 13G Cranberry, juice 0.300000 1.100 1.000 1307132001 13G Cranberry, juice - babyfood 0.300000 1.100 1.000 1307359000 13G Strawberry 0.400000 1.000 1.000 1307359001 13G Strawberry - babyfood 0.400000 1.00 0 1.000 1307360000 13G Strawberry, juice 0.400000 1.000 1.000 1307360001 13G Strawberry, juice - babyfood 0.400000 1.000 1.000 1400003000 14 Almond 0.250000 1.000 1.000 1400003001 14 Almond - babyfood 0.250000 1.000 1.000 1400004000 14 Almond, oil 0.250000 1.000 1.000 1400004001 14 Almond, oil - babyfood 0.250000 1.000 1.000 1400059000 14 Brazil nut 0.250000 1.000 1.000 1400068000 14 Butternut 0.250000 1.000 1.000 1400081000 14 Cashew 0.250000 1.000 1.000 1400092000 14 Chestnut 0.250000 1. 000 1.000 1400155000 14 Hazelnut 0.250000 1.000 1.000 1400156000 14 Hazelnut, oil 0.250000 1.000 1.000 1400185000 14 Hickory nut 0.250000 1.000 1.000 1400213000 1 4 Macadamia nut 0.250000 1.000 1.000 1400269000 14 Pecan 0.250000 1.000 1.000 1400282000 14 Pistachio 0.250000 1.000 1.000 1400391000 14 Walnut 0.250000 1.000 1.000 1500127000 15 Corn, sweet 1.500000 1.000 1.000 1500127001 15 Corn, sweet - babyfood 1.500000 1.000 1.000 2003128000 20C Cottonseed, oil 0.300000 1.000 1.000 2003128001 20C Cottonseed, oil - babyfood 0.300000 1.000 1.000 3100044000 31 Beef, meat 0.020000 1.000 1.000 3100044001 31 Beef, meat - babyfood 0.020000 1.000 1.000 3100045000 31 Beef, meat, dried 0.020000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 3100046001 31 Beef, meat byproducts - babyfood 0.200000 1.000 1.000 3100047000 31 Beef, fat 0.020000 1.000 1.000 3100047001 31 Beef, fat - babyfood 0.020000 1.000 1.000 3100048000 31 Beef, kidney 0.200000 1.000 1.000 3100049000 31 Beef, liver 0.200000 1.000 1.000 3100049001 31 Beef, liver - babyfood 0.200000 1.000 1.000

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 23 of 25 3200169000 32 Goat, meat 0.020000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 3200171000 32 Goat, fat 0.020000 1.000 1.000 3200172000 32 Goat, kidney 0.200000 1.000 1.000 3200173000 32 Goat, liver 0.200000 1.000 1.000 3300189000 33 Horse, me at 0.020000 1.000 1.000 3400291000 34 Pork, skin 0.020000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.020000 1.000 1.000 3400292001 34 Pork, meat byproducts - babyfood 0.020000 1.000 1.000 3400294000 34 Pork, kidney 0.020000 1.000 1.000 3400295000 34 Pork, liver 0.020000 1.000 1.000 3500339000 35 Sheep, meat 0.020000 1.000 1.000 3500339001 35 Sheep, meat - babyfood 0.020000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 3500341000 35 Sheep, fat 0.020000 1.000 1.000 3500341001 35 Sheep, fat - babyfood 0.020000 1.000 1.000 3500342000 35 Sheep, kidney 0.200000 1.000 1.000 3500343000 35 Sheep, liver 0.200000 1.000 1.000 3600222000 36 Milk, fat 0.010000 1.000 1.000 3600222001 36 Milk, fat - baby food/infant formu 0.010000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.010000 1.000 1.000 3600223001 36 Milk, nonfat solids - baby food/in 0.010000 1.000 1.00 0 3600224000 36 Milk, water 0.010000 1.000 1.000 3600224001 36 Milk, water - babyfood/infant form 0.010000 1.000 1.000 3600225001 36 Milk, sugar (lactose) - baby food/ 0.010000 1.000 1.000 3800221000 38 Meat, game 0.020000 1.000 1.000 4000094000 40 Chicken, liver 0.020000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.020000 1.000 1.000 4000095001 40 Chicken, meat byproducts - babyfoo 0.020000 1.000 1.000 4000097000 40 Chicken, skin 0.020000 1.000 1.000 4000097001 40 Chicken, skin - babyfood 0.020000 1.000 1.000 5000383000 50 Turkey, liver 0.020000 1.00 0 1.000 5000383001 50 Turkey, liver - babyfood 0.020000 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.020000 1.000 1.000 5000384001 50 Turkey, meat byproducts - babyfood 0.020000 1.000 1.000 5000386000 50 Turkey, skin 0.020000 1.000 1.000 5000386001 50 Turkey, skin - babyfood 0.020000 1.000 1.000 6000302000 60 Poultry, other, liver 0.020000 1.000 1.000 6000303000 60 Poultry, other, meat by products 0.020000 1.000 1.000 6000305000 60 Poultry, other, skin 0.020000 1.000 1.000 7000145000 70 Egg, whole 0.020000 1.000 1.000 7000145001 70 Egg, whole - babyfood 0.020000 1. 000 1.000 7000146000 70 Egg, white 0.020000 1.000 1.000 7000146001 70 Egg, white (solids) - babyfood 0.020000 1.000 1.000 7000147000 70 Egg, yolk 0.020000 1.000 1.000 7000147001 7 0 Egg, yolk - babyfood 0.020000 1.000 1.000 8601000000 86A Water, direct, all sources 0.395000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.395000 1.000 1.000 9500001000 O Acerola 2.500000 1.000 1.000 9500016000 O Artichoke, globe 1.500000 1.000 1.000 9500020000 O Avocado 0.600000 1.000 1.000 9500023000 O Banana 1.300000 1.000 1.000 9500023001 O Banana - babyfood 1.300000 1.000 1.000 9500024000 O Banana, dried 1.300000 3.900 1.000 9500024001 O Banana, dried - babyfood 1.300000 3.900 1.000 9500074000 O Canistel 0.600000 1.000 1.000 9500115000 O Coffee, roasted bean 0.200000 1.000 1.000 9500116000 O Coffee, instant 0.500000 1.000 1.000 9500151000 O Feijoa 2.500000 1.000 1.000 9500177000 O Grape, leaves 0.412000 1.000 1.000 9500178000 O Grape, raisin 3.000000 1.000 1.000 9500183000 O Guava 2.500000 1.000 1.000 9500183001 O Guava - babyfood 2.500000 1.000 1.000 9500188000 O Hop 10.000000 1.000 1.000 9500209000 O Longan 13.000000 1.000 1.0 00 9500211000 O Lychee 13.000000 1.000 1.000 9500212000 O Lychee, dried 13.000000 1.850 1.000

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 24 of 25 9500215000 O Mango 0.600000 1.000 1.000 9500215001 O Mang o - babyfood 0.600000 1.000 1.000 9500216000 O Mango, dried 0.600000 1.000 1.000 9500217000 O Mango, juice 0.600000 1.000 1.000 9500217001 O Mango, juice - babyfood 0.600000 1.000 1.000 9500245000 O Papaya 2.500000 1.000 1.000 9500245001 O Papaya - babyfood 2.500000 1.000 1.000 9500246000 O Papaya, dried 2.500000 1.800 1 .000 9500247000 O Papaya, juice 2.500000 1.500 1.000 9500252000 O Passionfruit 2.500000 1.000 1.000 9500252001 O Passionfruit - babyfood 2.500000 1.000 1.000 9500253000 O Pa ssionfruit, juice 2.500000 1.000 1.000 9500253001 O Passionfruit, juice - babyfood 2.500000 1.000 1.000 9500277000 O Persimmon 2.500000 1.000 1.000 9500279000 O Pineapple 0.300000 1.000 1.000 9500279001 O Pineapple - babyfood 0.300000 1.000 1.000 9500280000 O Pineapple, dried 0.300000 5.000 1.000 9500281000 O Pineapple, juice 0.300000 0.720 1.000 9500281001 O Pineapple, juice - babyfood 0.300000 0.720 1.000 9500283000 O Plantain 1.300000 1.000 1.000 9500284000 O Plantain, dried 1.300000 3.900 1.000 9500289000 O Pomegranate 0.500000 1.000 1.000 9500333000 O Sapote, Mamey 0.600000 1.000 1.000 9500351000 O Spanish lime 13.000000 1.000 1.000 9500358000 O Starfruit 2.500000 1.000 1.000 9500398000 O Watercress 2.000000 1.000 1.000

### Spirotetramat Dietary Exposure and Risk Assessment DP N o. 398858

Page 25 of 25 

## Attachment **5 : Chronic Results File**  U.S. EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for SPIROTETRAMAT NHANES 2003 - 2008 2 - day Residue file name: C: \ Documents and Settings \ jlangsda \ My Documents \ Chemicals \ Spirotetramat \ 2012 RCC \ Dietary \ Sent to Reviewers \ updated to include Kiwi \ updated SPIROTET RAMAT__CHRONIC__21 Dec 2012.R08 Adjustment factor #2 used. Analysis Date 12 - 21 - 2012/13:21:54 Residue file dated: 12 - 21 - 2012/11:38:57 Reference dose (RfD, Chronic) = .05 mg/kg bw/day

================= ============================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- To tal Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

------------ -------------------------- ------------- ---------------- **Total US Population 0.017785 35.6%** Hispanic 0.018737 37.5% Non - Hisp - White 0.017748 35.5% Non - Hisp - Black 0.015575 31.1% Non - Hisp - Other 0.021071 42.1% Nursing Infants 0.016243 32.5% No n - Nursing Infants 0.046105 92.2% Female 13+ PREG 0.016541 33.1% Children 1 - 6 0.032850 65.7% Children 7 - 12 0.018046 36.1% Male 13 - 19 0.012837 25.7% Female 13 - 19/NP 0.013480 27.0% Male 20+ 0.015660 31 .3% Female 20+/NP 0.016866 33.7% Seniors 55+ 0.016343 32.7% **All Infants 0.036886 73.8%** Female 13 - 50 0.015912 31.8% **Children 1 -**  **2 0.038038 76.1% Children 3**  **- 5 0.030925 61.9%**  **Children 6 -**  **12 0.019418 38.8%**  **Youth 13 -**  **19 0.013149 26.3% Adults 20**  **- 49 0.016159 32.3%**  **Adults 50 -**  **99 0.016494 33.0% Female 13**  **- 49**  **0.015902 31.8%**

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