Exhibit 10.1
 Sublease Agreement
 between
 Avanir Pharmaceuticals, Inc.  as Sublandlord
 and
 Halozyme,
Inc.  as Subtenant
 Building Address:
    
    11408 Sorrento Valley RoadSan Diego, California 92121




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Sublease Agreement
 This Sublease Agreement Sublease Effective Date Avanir Pharmaceuticals, Inc. Sublandlord Halozyme, Inc. Subtenant Halozyme Therapeutics, Inc. Parent Parties Party
 Witnesseth:
 Whereas Master Landlord Master Lease Exhibit A
 Whereas Master
Lease Premises Center
 Whereas Campus
  Whereas Sublease Premises
 Now, Therefore
 1. Summary and Definitions
 Base Rent
 1




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Period
        During Sublease Term
      
      Monthly
        Base Rent
      
      Annual
        Base RentSublease Commencement
          Date (estimated to be January 15, 2010), through and including
          January 14, 2011
      
      $2.25 per sq. foot per month or $20,670.75
      
      $248,049.00January 15, 2011
          through and including January 14, 2012
      
      $2.32 per sq. foot per month or $21,313.84
      
      $255,766.08January 15, 2012
          through and including January 14, 2013
      
      $2.39 per sq. foot per month or $21,956.93
      
      $263,483.16
 Improvement Allowance Allowance
 Sublease Premises Building
 Term Sublease Term Landlord Consent Sublease Commencement Date Sublease
Expiration Date
 Early Access/Sirion Premises
 Sirion Premises Sirion Sirion Sublease Sirion Sublease
Expiration Date Storage Space
 2




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Sub-Sublease Premises
  2. Sublease
 3. Condition of Sublease Premises
  3




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Paragraph 3
    4. Base Rent Paragraph 1
 5. Additional Rent Paragraph 4 Additional Rent Subtenants Rent
 4




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6. Rent Payments
 Paragraph 15 Paragraph 18
   7. Use
 5




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8. Operating Costs, Real Estate Taxes and Utilities
 Subtenants Pro Rata Share
 Exhibit F Additional Operating Costs
 Exhibit D Utilities Paragraph 8(a)
 6




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9. Status of Master Lease
     7




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10. Incorporation of Master Lease Terms
 Paragraph 10
 Paragraph 10
  Specific Section ExcludedSection
    
    Subject Matter
    
    (if not entire Section)Section 1
    
    Basic Lease Terms
    
    1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 1.10Section 2
    
    The PremisesSection 3
    
    Lease TermSection 4
    
    Rent
    
    Section 4.1 (Minimum Monthly Rent)Section 5
    
    Security DepositSection 6
    
    Operating Expenses
    
    6.1, 6.2, 6.5Section 8
    
    Real Property Taxes
    
    8.1, 8.2Section 16
    
    Damage and DestructionSection 17
    
    CondemnationSection 18
    
    Assignment and Subletting
    
    18.2(c)Section 20
    
    Surrender
    
    20.4Section 21
    
    Default by Tenant
    
    Section 21(d)(v)Section 23
    
    Default by Landlord
    
    23.3(a)Section 24
    
    General Provisions
    
    24.6
 8




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Rules and Regulations Sign Criteria
      9




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Paragraph 8(b)
 11. Insurance
 10




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12. Surrender of Sublease Premises; Holding Over
    11




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Paragraph
12(c)
  13. Waiver and Indemnification Paragraph 10
 14. Hazardous Materials
 Paragraph 10
  12




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15. Notices
 If to Sublandlord:
    
    Avanir Pharmaceuticals
101 Enterprise, Suite 300
Aliso Viejo, California 92656
Attention: Chief Financial OfficerWith a copy to:
    
    Goodwin Procterllp
4370 La Jolla Village Drive, Suite 400
San Diego, California 92122
Fax: (858) 232-0349
Attention: Ryan Murr, Esq.If to Subtenant:
    
    Halozyme, Inc.
11388 Sorrento Valley Road
San Diego, California 92121
Fax: (858) 704-8311
Attention: General CounselWith a copy to:
    
    Morrison & Foersterllp
425 Market Street
San Francisco, California 94105-2482
Fax: (415) 268-7522
Attention: Derek Boswell, Esq.
 Paragraph 15
 16. Tenant Improvement Allowance
 13




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Tenant Improvements
 17. Assignment and Subletting Permitted Transfer bona fide
 18. Interest on Subtenants Obligations
 19. Authority
 14




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20. Signage and Access
 21. Commissions
 22. Captions
 23. Successors and Assigns
 24. Parking
 25. Master Landlord Consent Exhibit C Exhibit C
 15




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26. Financial Statements
 27. Furniture, Fixtures and Equipment Exhibit B FF&E
 28. Parent Guaranty Exhibit E
 29. Cross Default
 30. Miscellaneous
   16




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[Remainder of page intentionally blank]
 17




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In Witness Whereof
 Sublandlord:
    Avanir Pharmaceuticals, INC.,
a Delaware corporationBy:Name:Title:Subtenant:
    Halozyme, Inc.,
a California corporationBy:Name:Title: Paragraph 28
 Parent:
    Halozyme Therapeutics, Inc.,
a Delaware corporationBy:Name:Title: 18




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Exhibit A
 Master Lease




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Exhibit B
 Furniture, Fixtures and Equipment




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Exhibit C
 Consent to Sublease Agreement  (11408 Sorrento Valley Road)




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Exhibit D
 Utilities
 Schedule of Utility Obligations: 11404 & 11408
 Vendor
    
    Service/Utility
    
    Status1.
    
    SDG&E
    
    Gas meter #0945199
(serves both buildings)
    
    Sublandlord to
provide for
Subtenant and pass
through prorated
costs2.
    
    San Diego Municipal Water
    
    Water (handled by
property manager)
    
    Sublandlord to
provide and pass
through prorated
costs to Subtenant3.
    
    Bay City Electric
(preventive
maintenance)
    
    Emergency generator
    
    Sublandlord to
provide and pass
through prorated
costs to Subtenant4.
    
    SDG&E
    
    Electric Meter #1769979
#1675220
#1730133
    
    Sublandlord to
provide and pass
through prorated
costs to Subtenant
Sublandlord to stay
on for outside
lights & emergency
power5.
    
    Biosources (outside
of the buildings
maintenance)
    
    HVAC system (interwoven
between 11404 & 11408)
    
    Sublandlord to
provide and pass
through prorated
costs to Subtenant
Subtenant to do own
HVAC maintenance
inside the building6.
    
    Trident
    
    Water treatment
    
    Sublandlord to
provide and pass
through prorated
costs to Subtenant




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Exhibit E
 This Guaranty of Lease Guaranty  Halozyme
Therapeutics, Inc. Guarantor Avanir
Pharmaceuticals Lessor  Lease Halozyme, Inc. Lessee Premises




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Bankruptcy Code




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If to Lessor:
    
    Avanir Pharmaceuticals
c/o Chief Financial Officer
101 Enterprise, Suite 300
Aliso Viejo, California 92656
Attention: Chief Financial OfficerWith a copy to:
    
    Goodwin Procterllp
4370 La Jolla Village Drive, Suite 400
San Diego, California 92122
Fax: (858) 232-0349
Attention: Ryan Murr, Esq.If to Lessee:
    
    Halozyme, Inc.
11388 Sorrento Valley Road
San Diego, California 92121
Fax: (858) 704-8311
Attention: General CounselWith a copy to:
    
    Morrison & Foersterllp
425 Market Street
San Francisco, California 94105-2482
Fax: (415) 268-7522
Attention: Derek Boswell, Esq.




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Waiver of Jury Trial The parties hereto waive trial by jury in any action,
proceeding or counterclaim brought by any party(ies) against any other party(ies) on any matter
arising out of or in any way connected with this Guaranty or the relationship of the parties
created hereunder (each, a Dispute and collectively, the Disputes).
 Consent to Judicial Reference




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In Witness Whereof
 Guarantor:
    Halozyme Therapeutics, Inc.,
a Delaware corporationBy:Name:Title:




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Exhibit F
 Additional Operating Costs




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