Exhibit 10.43


                AMENDMENT NO. 1 TO SUPPLY AND SERVICES AGREEMENT

      THIS AMENDMENT NO. 1 TO SUPPLY AND SERVICES  AGREEMENT (this  "Amendment")
is made and  entered  into as of the 12th day of February  2002 (the  "Effective
Date") by and between PROTEIN POLYMER TECHNOLOGIES, INC., a Delaware corporation
("PPTI") and SPINE WAVE, INC., a Delaware corporation ("Company") and amends the
terms and conditions of that certain Supply and Services  Agreement  dated as of
April 12, 2001 by and between the Company and PPTI (the "Original Agreement").


                              W I T N E S S E T H:


      WHEREAS, PPTI and Company are parties to the Original Agreement;

      WHEREAS,  PPTI and the Company desire to amend certain of the terms of the
Original Agreement;

      NOW, THEREFORE,  in consideration of the mutual covenants contained herein
and for other good and  valuable  consideration,  the receipt,  sufficiency  and
adequacy of which is hereby acknowledged, the parties hereto agree as follows:


<PAGE>


      A. Definitions and Sections. All capitalized terms used but not defined in
this  Amendment  shall  have  the  meanings  ascribed  thereto  in the  Original
Agreement.  Section  and  Schedule  references  in this  Amendment  shall  be to
Sections of and Schedules to the Original Agreement, as amended hereby.

      B.  Amendment of Section 2(a) and 2(b).  Sections 2(a) and 2(b) are hereby
deleted and amended and restated to read as follows:

            (a) During the Initial Term, PPTI shall provide Materials to Company
      and Company shall purchase Materials from PPTI for Non-Clinical Use as set
      forth in Amended and Restated Schedule 1 attached hereto.

            (b) During the Start-Up Term  subsequent  to the Initial Term,  PPTI
      shall  provide  Materials  to  the  Company  and  Company  shall  purchase
      Materials  from PPTI as set forth in the Amended and  Restated  Schedule 2
      attached hereto.

      C.  Amendment of Section  5.1. The last  sentence of Section 5.1 is hereby
deleted  and amended and  restated  to read as follows:  PPTI shall  provide the
accommodations  listed  above to the  Company  at no  additional  charge  to the
Company.

      D.  Amendment of Sections 6(c) and 6(d).  Sections 6(c) and (d) are hereby
deleted and amended and restated to read as follows:


<PAGE>


            (c) The parties agree that the Additional Term began on February 12,
      2002 and will end on February 11, 2003,  absent a default or breach of the
      Original  Agreement  as amended  hereby.  On the first day of March,  2002
      (subject to a fifteen (15) business day grace period) and on the first day
      of each of the next five (5) consecutive  months thereafter (e.g. April 1,
      2002 through August 1, 2002, both  inclusive),  the Company shall pay PPTI
      the sum of **. On the first day of September, 2002 and on the first day of
      each  consecutive  month  thereafter   throughout  the  remainder  of  the
      Additional  Term,  the  Company  shall pay PPTI the sum of **.  PPTI shall
      throughout the Additional Term continue to apply project accounting to the
      work under the  Original  Agreement  and within ** after the close of each
      month during the Additional  Term and within ** following the  termination
      of the Original Agreement, PPTI shall provide the Company with a statement
      (i) setting forth the Materials,  Additional Services, Design Services and
      other  services  provided  to Company by PPTI **, and (ii)  itemizing  any
      applicable  credits due to the  Company as set forth below and  additional
      payments due PPTI pursuant to paragraph (d) below.  The Company shall make
      any  payment  due to PPTI within ** after  receipt of the  statement.  Any
      credit due to the Company shall be ** during or for the  Additional  Term,
      exclusive of the monthly payments specified above.

            (d) Notwithstanding  anything else to the contrary contained herein,
      the parties agree that:

                  (i) Upon  expiration  of the Initial  Term, if the Company has
            paid the Minimum  Payment each month of the Initial Term and has not
            received an aggregate of Initial  Services and/or Materials equal to
            **, the Company shall ** for Materials,  Additional Services, Design
            Services  and/or  other  services   provided   hereunder  after  the
            Additional Term.

                  (ii)  Any  credit  due  the  Company  upon  expiration  of the
            Additional Term, may be applied to Materials,  Additional  Services,
            Design  Services  and/or  other  services   provided   hereunder  **
            following the  expiration of the  Additional  Term or as the Company
            may  reasonably  request  following  consultation  with  PPTI.  With
            respect  to  the  Injectable  Disk  Nucleus  product,  for  each  **
            subsequent to the Additional Term, **.

                  (iii) Intentionally omitted.

------------
**   Material is confidential and has been omitted and filed separately with the
Securities and Exchange Commission.


<PAGE>


                  (iv)  During  the  Additional  Term,  specific  external  PPTI
            expenses  authorized in writing by the Company for special supplies,
            services, or equipment in an amount ** in the aggregate per activity
            or task shall be paid by the Company to PPTI within ten (10) days of
            delivery of an invoice therefor from or on account of PPTI.


                  (v) **.

                  (vi) **.

                  (vii) On or before the first day of August, 2002, PPTI and the
            Company shall review the estimated  Materials,  Additional Services,
            Design  Services and/or other services to be provided by PPTI to the
            Company for the remainder of the


------------
**   Material is confidential and has been omitted and filed separately with the
Securities and Exchange Commission.

<PAGE>


            Additional Term. The Company agrees to **.

      E. Schedules.  The Amended and Restated  Schedules 1, 2, 3, and 5 attached
hereto  supercede and replace in their  entirety the existing  Schedules 1, 2, 3
and 5 to the Original Agreement.

      F. Continuing  Agreement.  Each party hereby  acknowledges that there have
occurred no defaults  under or breaches of the  Original  Agreement by the other
party.  Except as otherwise provided herein,  the Original  Agreement  continues
unchanged and in full force and effect.

      G.  Conflicts.  This  Amendment  supersedes  all prior or  contemporaneous
understandings or agreements,  whether written or oral,  between the Company and
the PPTI with respect to such  amendment.  In the event of any conflict  between
the terms of this Amendment and the terms of the Original  Agreement,  the terms
of this Amendment shall govern and control.

      H. Further Assurances.  The Company and PPTI agree to execute such further
instruments,  agreements and document, and to take such further action as may be
reasonably necessary to carry out the intent of this Amendment.

      I.  Counterparts.  This Amendment may be executed by the parties hereto in
one or more  counterparts and all of said  counterparts  taken together shall be
deemed to constitute one and the same instrument.

      J. Governing  Law. This  Amendment  shall be governed by, and construed in
accordance with, the laws of the State of California.


------------
**   Material is confidential and has been omitted and filed separately with the
Securities and Exchange Commission.

<PAGE>


      IN WITNESS  WHEREOF,  the parties  have caused this  Amendment  to be duly
executed as of the day and year first above written.


      SPINE WAVE, INC.


      By:/s/ Mark LoGuidice
         -------------------------------------
         Mark LoGuidice
         President and Chief Executive Officer


      PROTEIN POLYMER TECHNOLOGIES, INC.



      By:/s/ J. Thomas Parmeter
         -------------------------------------
         J. Thomas Parmeter
         President and Chief Executive Officer


<PAGE>


                         AMENDED AND RESTATED SCHEDULE 1

           MATERIALS DURING THE INITIAL TERM AND FOR NON-CLINICAL USE
           ----------------------------------------------------------



      During the Initial  Term,  PPTI shall supply  Materials to the Company for
Non-Clinical Use at the Company's request as follows:


--------------------------------------------------------------------------------

Material supplied by PPTI:               Cost to Company:
--------------------------               ----------------

--------------------------------------------------------------------------------

For  each  Qualified  Lot of  Material    ** per each Qualified  Lot
(except as set forth below)

--------------------------------------------------------------------------------
For each Off-the-Shelf Lot of Material    **.

--------------------------------------------------------------------------------

For each  Additional  Qualified Lot of    ** per each Qualified Lot
Material

--------------------------------------------------------------------------------

"Additional  Qualified Lot" shall mean any Qualified Lot of Material  ordered by
Company (i) after the Company  orders ** Qualified  Lots of Material and (ii) in
excess of ** for any ** period;  provided that, for purposes of clarity,  orders
in any ** shall be counted  toward  any ** period  with  either the  immediately
preceding or immediately subsequent month, but not both.

"Off-the-Shelf  Lot" shall mean any lot of Material existing in PPTI's inventory
as of the date of the Agreement.


------------
**   Material is confidential and has been omitted and filed separately with the
Securities and Exchange Commission.


                                 Schedule 1 - 1
<PAGE>


                         AMENDED AND RESTATED SCHEDULE 2

          MATERIALS DURING THE START-UP TERM SUBSEQUENT TO THE INITIAL
                           TERM AND FOR CLINICAL USE
          ------------------------------------------------------------


      During the Start-Up  Term  subsequent to the Initial Term or for purchases
of Materials made for Clinical Use during the Start-Up Term,  PPTI shall provide
Materials to the Company at the Company's request as follows:

--------------------------------------------------------------------------------

Material:                                Cost:
---------                                -----

--------------------------------------------------------------------------------

For each  Qualified  Lot*  supplied by    ** per each Qualified Lot, **
PPTI for  non-clinical  use (except as
set forth below)

--------------------------------------------------------------------------------

For   each   Excess   Qualified   Lot*    ** per each Excess Qualified Lot, **
supplied by PPTI for non-clinical use

--------------------------------------------------------------------------------

For each  Qualified  Lot*  supplied by    ** per each Qualified Lot, **
PPTI for clinical use

--------------------------------------------------------------------------------

Qualified Lot* supplied by third-party    ** per each Qualified Lot
contract manufacturer


--------------------------------------------------------------------------------


"Excess  Qualified  Lot" shall mean any  Qualified  Lot of  Material  ordered by
Company when PPTI  accepts  orders for more than ** of Material in any ** period
during the Additional Term, any such ** determined  consecutively from the start
of the Additional Term.

**


------------
**   Material is confidential and has been omitted and filed separately with the
Securities and Exchange Commission.


                                 Schedule 2 - 1
<PAGE>



                        AMENDED AND RESTATED SCHEDULE 3

                           QUALITY CONTROL PROCEDURES **
                           --------------------------



------------
**   Material is confidential and has been omitted and filed separately with the
Securities and Exchange Commission.

                                  Schedule 3-1
<PAGE>



                        AMENDED AND RESTATED SCHEDULE 5

                               ADDITIONAL SERVICES **
                               -------------------



------------
**   Material is confidential and has been omitted and filed separately with the
Securities and Exchange Commission.