Exhibit 10.1



                       PROTEIN POLYMER TECHNOLOGIES, INC.
                           8% SECURED PROMISSORY NOTE
                                DUE JULY 12, 2006
                                 AMENDMENT NO. 1
                               DATED JULY 12, 2006


         On April 13,  2006,  Protein  Polymer  Technologies,  Inc.,  ("Maker"),
issued to Matthew  J.  Szulik  ("Payee")  a note (the  "Note") in the  principal
amount of One Million  ($1,000,000.00)  Dollars  pursuant to which,  among other
things,  Maker agreed to pay the Obligations,  as defined  therein,  to Payee on
July 12, 2006, or sooner as otherwise  provided therein.  In accordance with the
terms of Section 10 (f) thereof, the Note is hereby amended as follows:

1.       In the first  paragraph  "July 12,  2006" is  changed to  "October  10,
2006."

         Maker  shall pay  additional  Interest to Payee in the amount of Twenty
Thousand  ($20,000) Dollars (the "Additional  Interest") for the extended period
of the Note as provided  herein upon the  execution of this  Amendment  No. 1 by
requesting Designee,  as defined in the Escrow Agreement,  dated as of April 13,
2006, among Maker, Taurus Advisory Group, LLC, as agent for Payee,  Designee and
Barry Feiner,  Esq., as Escrow Agent,  to direct the Escrow Agent, as defined in
the Escrow Agreement,  to pay the Additional  Interest to Payee as an expense of
Maker from the funds that the Escrow  Agent is  currently  holding in the Escrow
Account,  as defined in the Escrow Agreement,  as provided in Section 3.1 of the
Escrow Agreement.

         Counterparts.  This  Amendment  No.1  may be  executed  in one or  more
counterparts, including by facsimile, each of which shall be deemed an original,
but all  such  counterparts  together  shall  constitute  but  one and the  same
Amendment No. 1.

         Governing  Law. This Amendment No. 1 shall be governed by and construed
in accordance with the internal laws (and not the law of conflicts) of the State
of Connecticut.

         Except  as set  forth  above,  the  Note is not  modified,  changed  or
otherwise  amended and remains in full force and effect in  accordance  with its
terms as amended herein.


<PAGE>


Amendment No. 1, dated July 12, 2006
to $1,000,000.00 Secured Promissory Note
of Protein Polymer Technologies, Inc.
payable to Mathew J. Szulik
dated April 13, 2006


         IN WITNESS WHEREOF,  the undersigned have executed this Amendment No. 1
to the Note as of the day and year first above written.

                                Protein Polymer Technologies, Inc., Maker,
                                a Delaware corporation

                                By:  /s/ William N. Plamondon III
                                     -----------------------------------------
                                     William N. Plamondon III,
                                     Chief Executive Officer

                                Taurus Advisory Group, LLC, as agent for
                                Matthew J. Szulik, Payee

                                /s/ James Tagliaferri
                                -----------------------------------------
                                James Tagliaferri,
                                Managing Director




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