Exhibit 10.1


    
      

    


    FOURTH
      AMENDMENT TO LEASE

     

    THIS
      FOURTH AMENDMENT TO LEASE ("Amendment") made as of the 7th day
      of March,
      2007 by and between 111 BARCLAY ASSOCIATES ("Landlord"), sole beneficiary under
      CHICAGO TITLE LAND TRUST COMPANY, as successor trustee to LASALLE BANK
NATIONAL
      ASSOCIATION, as successor trustee to AMERICAN NATIONAL BANK AND TRUST
      COMPANY OF CHICAGO, under Trust Agreement dated January 1, 1991 and known
as
      Trust No. 113370-03 ("Trustee"), and BIOSANTE PHARMACEUTICALS, INC.
      ("Tenant").

     

    W
      I T N E S S E T H:

     

    WHEREAS,
      Landlord and Tenant entered into that certain Lease dated December 19, 2003,
      as
      amended by First Amendment to Lease dated February 26, 2004, as modified by
      Letter Amendment dated March 19, 2004 (the "Lease"), as amended by Second
      Amendment to Lease dated January 4, 2005, and as amended by Third Amendment
      to
      Lease dated January 27, 2006, which
      Lease demised to Tenant a portion of the 2nd
      floor, known as Suite 280 ("Premises") of the building
      known as 111 Barclay Boulevard, Lincolnshire, Illinois ("Building");
      and

     

    WHEREAS,
      the parties hereto desire to extend the term of the Lease and to amend the
      Lease
      in certain other respects.

     

    NOW,
      THEREFORE, in consideration of the mutual covenants and conditions contained
      herein,
      the Lease is hereby further amended as follows:

     

    1.  Extended
      Term.
      The term of the Lease is hereby extended to March 21, 2008 on the same terms
      and
      conditions as set forth in the Lease, except as modified herein and unless
      sooner terminated pursuant to the terms of the Lease.

     

    2.  Rent.
      As of March 22, 2007, the Base Rent payable under the Lease shall be as
follows:

    


     

    
      	
              Period

            	 	
              Annual
                Base Rent

            	 	
              Monthly
                Installment

            
	
              3/22/07-3/21/08

            	 	
              $90,113.25

            	 	
              $7,509.43

            


    

     

    3.  Work.
      Landlord shall, at Landlord's expense, clean the carpeting in the
      Premises.

     

    4.  Real
      Estate Brokers.
      Tenant represents that it has dealt with, and only with Van Vlissingen
      and Co., as broker in connection with this Amendment, and that, insofar as
      Tenant knows, no other broker negotiated this Amendment or is entitled to any
      commission in connection
      therewith. Tenant agrees to indemnify and hold Landlord harmless from all
      damages, liability and expense (including reasonable attorneys' fees) arising
      from any claims or demands of any
      other broker or brokers or finders in connection with its participating with
      Tenant in the negotiating
      of this Amendment.


    
      
        
        

      

      
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    5.  Lease
      in Full Force and Effect.
      Except for the provisions of this Amendment, all the terms,
      covenants and conditions of the Lease and all the rights and obligations of
      Landlord and Tenant
      thereunder, shall remain in full force and effect, and are not otherwise
      altered, amended, revised or changed.

     

    6.  Estoppel.
      Tenant and Landlord hereby each acknowledge that as of the date hereof,
they
      have no claims arising under the Lease against the other party or its agents,
      or
      any one or more of the foregoing, and that neither knows of any default or
      failure on the part of the other party
      to keep or perform any covenant, condition or undertaking to be kept or
      performed by such other party under the Lease.

     

    7.  Exculpatory
      Provisions.
      It is expressly understood and agreed by and between the parties
      hereto, anything herein to the contrary notwithstanding, that each and all
      of
      the representations, warranties, covenants, undertakings and agreements herein
      made on the part of the Landlord while in form purporting to be the
      representations, warranties, covenants, undertakings,
      and agreements of the Landlord are nevertheless each and every one of them
      made
and
      intended, not as personal representations, warranties, covenants, undertakings,
      and agreements
      by the Landlord or for the purpose or with the intention of binding the Landlord
      personally, but are made and intended for the purpose only of subjecting the
      Landlord's interest in
      the Building, the Land and the Premises to the terms of this Amendment and
      for
      no other purpose
      whatsoever, and in case of default hereunder by the Landlord (or default
      through, under, or
      by any of its agents or representatives), the Tenant shall look solely to the
      interests of the Landlord in the Building and Land.

     

    [REMAINDER
      OF PAGE INTENTIONALLY LEFT BLANK; SIGNATURE PAGE
      FOLLOWS.]


    
      
        
        

      

      
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    IN
      WITNESS WHEREOF, the parties have caused this Amendment to be executed on the
      date first above written.

    


     

    
      	 	 	
              LANDLORD:

            	 	 
	 	 	 	 	 	 
	 	 	
              111
                BARCLAY ASSOCIATES

            	 
	 	 	 	 	 	 
	 	 	
              By:

            	
              Van
                Vlissingen & Co., its authorized agent 

            	 
	 	 	 	 	 
	 	 	
              By:

            	/s/	 
	 	 	 	
              Its:

            	President  
              	 
	 	 	 	 
	 	 	
              TENANT: 

            	 
	 	 	 	 	 	 
	 	 	
              BIOSANTE
                PHARMACEUTICALS, INC. 

            	 
	 	 	 	 	 	 
	 	 	
              By:

            	/s/
              Phillip B. Donenberg	 
	 	 	 	
              Its: 

            	CFO  
              	 


    

    

       

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