Amended and Restated Collaboration and License Agreement



 Exhibit 10.31 
 EXECUTION VERSION 
 ***Text Omitted and Filed Separately 

with the Securities and Exchange Commission. 
 Confidential Treatment Requested 
 Under 17 C.F.R. Sections 200.80(b)(4)

 and 230.406 
 AMENDED AND RESTATED 
 COLLABORATION AND LICENSE AGREEMENT

 between 
 REGULUS THERAPEUTICS INC. 
 And 

SANOFI 







 AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT 

THIS AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT (the “Agreement”) is made and entered into
this July 16, 2012 (the “Effective Amendment Date”), by and between SANOFI (formerly, SANOFI-AVENTIS), a French Corporation
(“Sanofi”) having a place of business at 54, rue la Boétie, 75008, Paris, France, registered in the Paris Trade and Company Register under no. 395 030 844, and REGULUS THERAPEUTICS
INC., a Delaware Corporation (“Regulus”) having a place of business at 3545 John Hopkins Court, San Diego, California 92121-1121. Sanofi and Regulus each may be referred to herein individually as a
“Party,” or collectively as the “Parties.” 
 WHEREAS, Regulus possesses
certain patent rights, know-how and technology with respect to therapeutic microRNA Compounds; 
 WHEREAS, Regulus and
Sanofi entered into a Collaboration and License Agreement (the “Original Agreement”) dated June 21, 2010 (the “Effective Date”), under which the Parties agreed to conduct a Research Program to
identify one or more Licensed Compounds for a limited number of Collaboration Targets and that Sanofi has exclusive rights to Licensed Compounds and Products arising from the Research Program; 

WHEREAS, Sanofi and Regulus desire to amend and restate the Original Agreement with this Agreement; and 

NOW, THEREFORE, in consideration of the foregoing and the mutual covenants herein contained, the Parties do hereby agree as
follows. 
 ARTICLE 1 
 DEFINITIONS 
 The terms used in this Agreement with initial letters
capitalized, whether used in the singular or the plural, will have the meaning set forth in APPENDIX 1, or if not listed in APPENDIX 1, the meaning designated in places throughout the Agreement.

 ARTICLE 2 
 GRANT OF RIGHTS; EXCLUSIVITY 
 Section 2.1 License Grants to
Sanofi. Subject to the terms and conditions of this Agreement, Regulus hereby grants to Sanofi a worldwide, royalty-bearing, exclusive license, with the right to grant sublicenses as set forth in Section 2.2 below, under the Regulus
Know-How and Regulus Patents to Research, Develop, make, have made, use, gain Approval, Commercialize, sell, offer for sale, have sold, export and import Licensed Compounds and Products and Companion Diagnostics in the Product Field. 

Section 2.2 Sublicenses. The licenses granted to Sanofi under Section 2.1 are sublicensable only in connection with a
sublicense of a Licensed Compound or Product to any 







 
Affiliate of Sanofi or to any Third Party, in each case to Research Develop, make, have made, use, gain Approval, Commercialize, sell, offer for sale, have sold, export and import Licensed
Compound or Product in the Product Field in accordance with the terms of this Agreement. 
 Section 2.3 Exclusivity.

 2.3.1 During the Term, on a Collaboration Target-by-Collaboration Target basis, so long as the exclusive license
granted to Sanofi under Section 2.1 is in effect, Regulus agrees that it will not work, independently of the Research Program, either by itself or with any Third Party (including the grant of any license to any Third Party), to discover,
research, develop and/or commercialize any microRNA Compound that is (i) a microRNA Antagonist [...***...] such Collaboration Target or (ii) a microRNA Mimic designed to mimic the activity of such Collaboration Target. In addition,
on a microRNA-by-microRNA basis, for as long as a microRNA is not a Collaboration Target but the subject of target validation under the Research Program, Regulus agrees that it will not work, independently of the Research Program, either by itself
or with any Third Party (including the grant of any license to any Third Party), to discover, research, develop and/or commercialize any microRNA Compound that is (i) a microRNA Antagonist [...***...] such microRNA or (ii) a microRNA
Mimic designed to mimic the activity of such microRNA. 
 2.3.2 During the Term, on a Collaboration
Target-by-Collaboration Target basis, so long as the exclusive license granted to Sanofi under Section 2.1 is in effect, Sanofi agrees that it will not work independently of this Agreement in collaboration with any Third Party (including the
grant of any license to or from any Third Party) to discover, research, develop and/or commercialize (i) with respect to Collaboration Targets that are the subject of the exclusive license under Section 2.1 where the applicable Product
contains a microRNA Antagonist, microRNA Compounds that are [...***...] such Collaboration Target; and (ii) with respect to Collaboration Targets that are the subject of the exclusive license under Section 2.1 where the applicable
Product contains a microRNA Mimic, microRNA Compounds with a substantially similar base composition as the applicable Collaboration Target that are designed to mimic the activity of such Collaboration Target, in each case (both (i) and
(ii) above) only in the Therapeutic Field for which the applicable Product is being developed and/or commercialized. 

Section 2.4 License Conditions; Limitations. 
 2.4.1 If Sanofi fails to meet any of its obligations under Section 3.5.1 and Section 6.2, and such failure rises to the level of a material breach of this Agreement, then Regulus will
have the termination rights set forth in Section 9.3. 
 2.4.2 If Sanofi fails to meet its obligations to use
Commercially Reasonable Efforts under ARTICLE 5 for a particular Licensed Compound or Product, Regulus will have the termination rights set forth in Section 9.4. 
 2.4.3 The license and exclusivity granted under Section 2.1 and Section 2.3 are subject to and limited by the (i) Existing Regulus Agreements and (ii) [...***...]


  
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 [...***...], solely to the extent Regulus has, prior to the Effective Date, [...***...].

 2.4.4 Without limiting this Section 2.4, Regulus’ ability to conduct research and development on
[...***...], and Regulus’ ability to grant Sanofi a license under Section 2.1 to Develop and Commercialize [...***...], is limited by, and subject to, the terms of the [...***...]. Regulus will use commercially reasonable
efforts (and will [...***...]) to secure the right to conduct research and development on [...***...] under the R&D Plan, and grant Sanofi a license under Section 2.1 to Develop and Commercialize Licensed Compounds that are
[...***...] to the fullest extent contemplated by this Agreement. 
 2.4.5 Without limiting this Section 2.4,
Regulus’ ability to conduct research and development on microRNA Compounds in the Therapeutic Field of [...***...], and Regulus’ ability to grant Sanofi a license under Section 2.1 to Develop and Commercialize microRNA Compounds
in the Therapeutic Field of [...***...] is limited until the date [...***...] which in no event shall be later than [...***...])[...***...], as in effect on the Effective Date. Subject to the preceding sentence, Regulus will
secure the right to grant Sanofi a license under Section 2.1 to Develop and Commercialize Licensed Compounds in the Therapeutic Field of [...***...] to the fullest extent contemplated by this Agreement. The fact that Sanofi has been, or
will be granted any rights by Regulus in the Therapeutic Field of [...***...] shall be deemed Sanofi Confidential Information [...***...]. 
 2.4.6 Subject to Section 2.3, Regulus retains the right to grant Permitted Licenses. 
 2.4.7 The [...***...] granted to Sanofi under the [...***...] Agreement is subject to the terms of the [...***...] Agreement (including for the avoidance of doubt the
[...***...] obligation vis-à-vis [...***...] to provide reports in accordance with [...***...] Agreement, and to keep records as set forth in Article 10 of the [...***...] Agreement, provided that Regulus agrees
to directly comply with the reporting obligations under the [...***...] Agreement with respect to progress of research and development. To the extent necessary to comply with the reporting obligations under the [...***...] Agreement,
Sanofi agrees to provide Regulus with reports of Sanofi’s progress through the JSC for so long as the JSC in place, and thereafter as reasonably requested by Regulus, in each case, at intervals and with reasonable lead-times reasonably
necessary for Regulus to comply with the [...***...] Agreement. Based on the information reported by Sanofi pursuant to the preceding sentence, Regulus will prepare the necessary reports and submit them to [...***...]. However, if
[...***...] insists that Sanofi provide written progress, Sanofi agrees to do so. The parties shall cooperate in good faith to facilitate compliance with the Existing Regulus Agreements. Notwithstanding the foregoing, Regulus shall make a good
faith effort to [...***...] that the [...***...] of the [...***...] the reporting obligations that Sanofi has to Regulus under this Agreement. 

  
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 ARTICLE 3 
 COLLABORATION 
 Section 3.1 Objective. The Parties will
collaborate in carrying out a program to discover and preclinically develop Licensed Compounds (as further provided for in the R&D Plan, the “Research Program”), for the clinical Development and Commercialization of such
Licensed Compounds by Sanofi as Products. 
 Section 3.2 R&D Plan. The Research Program will be carried out in
accordance with a written research and development plan (the “R&D Plan”). The initial R&D Plan that has been agreed to by the Parties as of the Effective Date is attached as APPENDIX 8 hereto.
Within 60 days after the Effective Amendment Date, the JSC shall update and amend the R&D Plan to incorporate the plans set forth in APPENDIX 8-A attached hereto. The purpose of the R&D Plan is to detail the
responsibilities and activities of Regulus and Sanofi with respect to carrying out the Research Program. The R&D Plan will include a description of the specific activities to be performed by the Parties in support of the Research Program, the
number of FTEs to be committed by Regulus to perform such activities, and projected timelines for completion of such activities. The R&D Plan, including the definition of Development Candidate, the Development Candidate selection criteria, and
the Target Product Profile, may be amended with the approval of the JSC (with the Senior Representative of Sanofi having the final decision in the case of a dispute between the Parties over such matters, except as set forth in the JSC Charter). The
R&D Plan will be updated and amended from time to time, but at least annually. In addition, at the time a Development Candidate is designated, the JSC will meet to update the R&D Plan to implement the Manufacturing Technology transfer under
Section 4.3 and to secure supply of API to support Phase 1 Trials, the cost of which will be borne solely by Sanofi. If the Parties cannot agree to updates or amendments to the R&D Plan, the Parties will first pursue the dispute resolution
provisions of the JSC Charter and thereafter follow the provisions of Section 13.4. 
 Section 3.3 Research Term.

 3.3.1 The Research Program will be carried out during the period following the Effective Date and ending on the
third anniversary of the Effective Date unless extended pursuant to Section 3.3.2 (such period, including any extensions pursuant to Section 3.3.2, the “Research Term”). 

3.3.2 Sanofi will have the option to extend the Research Term for two additional one-year periods, such that the Research Term may
be extended through the fourth and fifth anniversary of the Effective Date. For any extension of the Research Term, the JSC will amend and restate the R&D Plan as necessary, subject to the provisions of the JSC Charter. 

3.3.3 In order to exercise its option under Section 3.3.2 to extend the Research Term, Sanofi must provide Regulus a written
notice exercising Sanofi’s right to extend the Research Term at least [...***...] days prior to the scheduled expiration of the Research Term. If Sanofi does not timely provide such written notice, the Research Term will end when
scheduled. In addition, no earlier than the [...***...] day prior to the scheduled expiration of the Research Term, Regulus may request in writing from Sanofi a nonbinding, good faith indication of


  
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whether or not Sanofi intends to extend the Research Term. In such event, Sanofi will provide such nonbinding, good faith indication to Regulus at least [...***...] days prior to the
scheduled expiration of the Research Term. 
 Section 3.4 Joint Steering Committee. The Parties will establish and
maintain a joint steering committee (the “JSC”) to oversee the conduct of the Research Program, including, but not limited to approving any changes to the R&D Plan. The JSC will be established, operated and governed in
accordance with the policies and procedures set forth in APPENDIX 4 attached hereto (the “JSC Charter”). The JSC Charter may be amended with the unanimous approval of the JSC members. As needed, the JSC
will establish subcommittees and working groups that will report to the JSC to further the objectives of the Research Program. The JSC and any subcommittees and working groups established by the JSC will automatically dissolve at the end of the
Research Term. 
 Section 3.5 Research Program Staffing; Funding; and Resources. Regulus will dedicate Regulus
employees during the Research Term to perform activities in support of and in accordance with the then-current R&D Plan. 

3.5.1 Regulus will invoice Sanofi on or after the Effective Date for, and Sanofi will pay Regulus, an irrevocable, non-creditable
and nonrefundable payment of five million dollars ($5,000,000) to support Regulus’ work under the Research Program for the first year of the Research Term. Regulus will invoice Sanofi on or after the first anniversary of the Effective Date and
on or after each subsequent anniversary of the Effective Date during the Research Term (including any extension under Section 3.3.2) for, and Sanofi will pay Regulus, an irrevocable, non-creditable and nonrefundable payment of five million
dollars ($5,000,000) to support Regulus’ work under the Research Program for such year. Regulus will invoice Sanofi for each such payment and Sanofi will pay each such invoice in accordance with Section 6.13. Regulus agrees and covenants
to Sanofi that, unless otherwise previously agreed in writing between the Parties, (a) all payments received by Regulus under this Section 3.5.1 shall be dedicated exclusively to Regulus’ performance of the Research Program and
(b) no portion of any payment received by Regulus under this Section 3.5.1 shall be used to conduct target validation activities with respect to any microRNA unless such microRNA is designated as the subject of such activities in the
R&D Plan. 
 3.5.2 Except for the payments under Section 3.5.1 above, Regulus will bear all costs, including
costs related to research supplies, consumables and animals, in performing its obligations under the R&D Plan. In accordance with the foregoing, if the JSC determines that any of Regulus’ obligations under the R&D Plan could be
performed better, or faster by Sanofi, then Sanofi shall have the opportunity to perform such work [...***...] on a scope of work and budget, consistent with [...***...] require to perform the same; and Regulus will pay Sanofi for such
work in accordance with such budget. For clarity, Regulus will perform, and bear all costs of performing, all IND-Enabling Studies to the extent required by the FDA to support the IND for the Target Product Profile that was approved by the JSC prior
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 3.5.3 Regulus shall commit the necessary resources to use commercially reasonable
efforts to (a) provide Sanofi with a [...***...] microRNA targets in [...***...] Fibrosis [...***...] by [...***...], (b) [...***...] no later than [...***...], and (c) receive [...***...] for
Licensed Compounds during [...***...]; in each case consistent with the R&D Plan. Without limiting the foregoing, during the Research Term, Regulus shall commit the necessary resources and use Commercially Reasonable Efforts to
(a) [...***...]. 
 Section 3.6 Collaboration Targets. Sanofi will have a license under Section 2.1
for up to four microRNAs (including Mir-21 as of the Effective Date) designated by Sanofi in accordance with Section 3.6.1 below, for research and development under the R&D Plan (each such designated microRNA is a “Collaboration
Target”). At each JSC meeting (including the initial meeting to be held promptly following the Effective Date), Regulus will provide an update to Sanofi regarding all material results of Regulus’ research and discovery efforts,
including the identity of each microRNA (excluding any microRNA that is encumbered by the [...***...]) that is the subject of Regulus’ efforts under the Research Program. In addition, Regulus may, from time-to-time, provide the JSC with
microRNA targets that have been validated by Regulus, independently of the Research Program. To this end, the Parties agree to hold an audio or video teleconference meeting of the JSC within 10 Business Days after the Effective Date and the initial
face-to-face meeting of the JSC within eight (8) weeks after the Effective Date. Each microRNA provided by Regulus to the JSC pursuant to this Section 3.6 is a “Proposed Target” hereunder. The Collaboration Targets,
including whether Sanofi’s rights for such Collaboration Targets are for a microRNA Antagonist or a microRNA Mimic, will be listed on APPENDIX 6, which may be updated from time to time by the Parties in accordance with
this Section 3.6. Sanofi may designate up to four Collaboration Targets at any time during the Research Term; provided, however, that if Sanofi wishes to designate a Collaboration Target after the [...***...], Sanofi must first
have extended the Research Term for at least [...***...] in accordance with Section 3.3.2. 
 3.6.1 Designating
Collaboration Targets. As of the Effective Date, Sanofi has designated Mir-21 as a Collaboration Target to approach with a microRNA Antagonist. If during the Research Term there are less than four Collaboration Targets, Sanofi may designate a
new microRNA as a Collaboration Target by providing Regulus with a written notice (the “Request Notice”) of the microRNA it wishes to designate as a Collaboration Target (the “Requested Target”). Each
Requested Target may be selected from the Proposed Targets or may be any other microRNA. The Request Notice will include the microRNA name and the miRBase Accession Number, and whether Sanofi wants to approach such Requested Target with a microRNA
Antagonist or a microRNA Mimic. Within 15 Business Days of receipt of the Request Notice, Regulus will give Sanofi written notice (i) stating if any of the criteria set forth in clauses (a) or (b) below applied to such Requested
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Request Notice (or otherwise confirming that such Requested Target is available); and (ii) only if none of clauses (a) or (b) below applied to such Requested Target at the time of
Regulus’ receipt of the Request Notice, disclosing all relevant Existing Regulus Agreements and Future Regulus Agreements and the [...***...] and other potential encumbrances known by Regulus and related to the Requested Target
(“Target Encumbrances”). If, and only if, at the time of Regulus’ receipt of the Request Notice, the Requested Target: 
 (a) is the subject of [...***...] an exclusive license granted by Regulus to a Third Party that would prohibit Regulus from collaborating with Sanofi under this Agreement or from granting a
license under Section 2.1 with respect to the Requested Target; or 
 (b) is not a Proposed Target and has been
approved in accordance with [...***...] procedures, consistently applied to [...***...] research programs, as the subject of an [...***...] research program, [...***...], with committed resources, as reflected in the minutes
of the proceedings of [...***...]. For purposes of this paragraph, “[...***...]” means the [...***...] responsible for approving the commitment of resources to an [...***...]; 

then, and only then, in each case, the Requested Target will be rejected and will not become a Collaboration Target. If the Requested Target is rejected,
Sanofi can request another microRNA in accordance with the terms of this Section 3.6.1. If the Requested Target is not rejected, the Requested Target will become a Collaboration Target upon payment by Sanofi to Regulus of the applicable target
designation milestone under Section 6.3; provided, however, that if the Requested Target has any Target Encumbrances (and Regulus has disclosed such Target Encumbrances to Sanofi), before such Requested Target can become a Collaboration
Target, Sanofi must agree in writing (within 30 days of receiving from Regulus the description of such Target Encumbrances and subject to the allocations set forth in Section 6.8) to assume all applicable Target Encumbrances for such Requested
Target. Whenever a microRNA becomes a Collaboration Target, the JSC will promptly update the R&D Plan and the Parties will promptly update APPENDIX 6 to add the new Collaboration Target and whether Sanofi’s rights for
such Collaboration Target will be related to a microRNA Antagonist or a microRNA Mimic. For clarity, Sanofi may designate both a microRNA Antagonist and a microRNA Mimic for the same microRNA under this Section 3.6.1, but the microRNA
Antagonist and the microRNA Mimic will each count as a separate Collaboration Target. 
 3.6.2 Right of Substitution. At
any time during the Research Term and subject to the procedures set forth below, by written notice to Regulus, Sanofi may substitute a new microRNA for an existing Collaboration Target; provided that: 

(a) unless unanimously agreed by the JSC, Sanofi may not substitute a Collaboration Target during the first [...***...]
months following the applicable Request Notice for such Collaboration Target; 
 (b) Sanofi may only substitute
Collaboration Targets for which Regulus has not generated a microRNA Compound satisfying the Development Candidate 

  
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selection criteria set out in the R&D Plan, within [...***...] months of the applicable Request Notice for such microRNA; 

(c) Sanofi may not substitute a Collaboration Target if Regulus has [...***...] for a Licensed Compound targeting or
mimicking such Collaboration Target; 
 (d) Sanofi may not substitute another microRNA for Mir-21, unless Regulus has
not [...***...] for a Mir-21 Compound by [...***...]; and 
 (e) Sanofi may not make more than
[...***...] such substitutions under this Section 3.6.2(e) during the Research Term, provided that if Sanofi extends the Research Term until the [...***...] anniversary of the Effective Date pursuant to Section 3.3.2, then the
maximum number of substitutions under this Section 3.6.2 that Sanofi may make during the Research Term as so extended shall be [...***...]. Notwithstanding the foregoing, the JSC may unanimously agree to make a Collaboration Target
substitution, in which event such substitution shall not count toward the applicable maximum number of substitutions set forth in the preceding sentence. 
 If Sanofi elects to substitute a Collaboration Target under this Section 3.6.2, then Sanofi will provide written notice to Regulus, which written notice shall include a proposed new microRNA for
consideration (including its name, the miRBase accession number for the proposed microRNA) as a new Collaboration Target. Regulus shall approve or reject such proposed substitution microRNA in accordance with the criteria on which a Requested Target
becomes a Collaboration Target as set forth in Section 3.6.1. Any microRNA that is substituted-out of the Research Program will no longer be considered a Collaboration Target and Regulus’ obligations under this Agreement with respect to
such substituted-out microRNA (including but not limited to Section 2.3) will terminate. For purposes of clarity, Sanofi will not have to pay an additional target designation milestone under Section 6.3 for a replacement Collaboration
Target under this Section 3.6.2. 
 3.6.3 Confidentiality. The fact that Sanofi has designated a particular microRNA
as a Collaboration Target is Sanofi Confidential Information. The fact that Regulus has rejected a particular microRNA under Section 3.6.1 is Regulus Confidential Information. 

3.6.4 End of Research Term. Upon the expiration of the Research Term, (a) Regulus will not be obligated to continue to
perform work under the Research Program; (b) Sanofi may not designate any additional (or substituted) Collaboration Targets under Section 3.6; and (c) subject to Regulus’ obligations under Section 2.3, Regulus will
[...***...] any data generated under the R&D Plan for any microRNA that is not a Collaboration Target, including any microRNA Compound antagonizing or mimicking such microRNA. 

Section 3.7 Research Program Records. Each Party and its contractors will maintain complete and accurate records of all work
conducted in the performance of the Research Program, an accounting of the number of FTEs committed by Regulus, and all results, data, inventions and developments made in the performance of the Research Program. Such records will be in sufficient
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regulatory purposes. Upon reasonable prior written notice, Regulus will provide Sanofi the right to inspect such records, and will provide copies of all requested records, to the extent
reasonably required for the performance of Sanofi’s rights and obligations under this Agreement. Upon reasonable prior written notice, and solely with respect to Discontinued Products, Sanofi will provide Regulus the right to inspect such
records, and will provide copies of all requested records, to the extent reasonably required for the performance of Regulus’ rights and obligations under this Agreement. In each case, each Party will maintain such records and the information it
receives from the other Party in confidence in accordance with Article 7 hereof and will not use such records or information except to the extent otherwise permitted by this Agreement. 

Section 3.8 Disclosure of Results of Research Program. The results of all work performed by the Parties as part of the
Research Program will be promptly disclosed to the other Party in a reasonable manner as such results are obtained. In addition, Regulus will periodically provide Sanofi with written reports of the work performed under the Research Program, the
number of FTEs committed, and the results achieved by Regulus. Regulus and Sanofi will provide reports and analyses at each JSC meeting, and more frequently on reasonable request by the JSC, detailing the current status of the Research Program. The
results, reports, analyses and other information regarding the Research Program disclosed by one Party to the other Party pursuant hereto may be used only in accordance with the rights granted and other terms and conditions under this Agreement.
Upon reasonable request by Sanofi, Regulus will provide Sanofi with additional data, results and other information with respect to the work performed by Regulus in the performance of the Research Program. Any reports required, excluding reports
needed for submission to a Regulatory Agency, under this Section 3.8 may take the form of and be recorded in minutes of the JSC that will contain copies of any slides relating to the results and presented to the JSC. Reports needed to support
regulatory submissions and updates to a Regulatory Agency will be provided in a timely manner and in a format as agreed upon by the JSC. 
 Section 3.9 Research Efforts; Resources, Scientific Manner. Each Party will use Commercially Reasonable Efforts to perform the Research Program, including its responsibilities under the
R&D Plan. 
 3.9.1 Throughout the Research Term, Regulus will assign no less than the number of qualified scientists
specified in the R&D Plan to perform the work set forth in the then-applicable R&D Plan. The mixture of skills and levels of such employees will be appropriate to the scientific objectives of the Research Program. 

3.9.2 Each Party will maintain laboratories, offices, administrative support and all other facilities at its own expense and risk
necessary to carry out its responsibilities under the R&D Plan. Each Party agrees to make its employees reasonably available at their respective places of employment to consult with the other Party on issues arising during the performance of the
Research Program. Sanofi and Regulus will cooperate with each other in carrying out the Research Program, and each Party will contribute its relevant know-how and experience necessary to carry out the Research Program. 

3.9.3 The Research Program will be conducted by each Party in good scientific manner, and in compliance with all applicable GCP,
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requirements, to attempt to achieve efficiently and expeditiously the Objectives of the Research Program. Each Party will comply with all Applicable Laws, in the performance of work under this
Agreement. 
 3.9.4 Regulus will not perform any of its obligations under the R&D Plan through one or more
subcontractors or consultants, without the prior written approval of Sanofi, such approval not to be unreasonably withheld; except that Regulus may (i) enter Permitted Licenses; and (ii) engage consultants and subcontractors in the
ordinary course that generally support Regulus’ research and development infrastructure, provided that (a) each such consultant and subcontractor agrees in writing to assign to Regulus all Know-How and Patents conceived made or
reduced to practice in performing services for Regulus, and (b) Regulus will solely bear any costs associated with Regulus’ use of such consultants and subcontractors. Sanofi will promptly notify Regulus regarding any Third Party Sanofi
uses to conduct research under the R&D Plan or that Sanofi transfers Compounds or Products to, including identifying such Third Party. 
 Section 3.10 Materials Transfer. In order to facilitate the Research Program, either Party may provide to the other Party certain materials for use by the other Party in furtherance of the
Research Program. All such materials will be used by the receiving Party in accordance with the terms and conditions of this Agreement solely for purposes of performing its rights and obligations under this Agreement, and the receiving Party will
not transfer such materials to any Third Party unless expressly contemplated by this Agreement or upon the written consent of the supplying Party. 
 Section 3.11 Pharmacovigilance; Safety Database. Prior to IND transfer, designated staff from the respective Headquarter Pharmacovigilance Department shall be requested by the Joint Steering
Committee to establish a detailed Safety Data Exchange Agreement (“SDEA”) for the Licensed Products to be in place prior to Sanofi starting any clinical development. Notwithstanding the foregoing, the Parties agree to the
following principles: 
 3.11.1 Sanofi will establish the global safety database for the Licensed Compounds/Products that
will be used for regulatory reporting and responses to safety queries from Regulatory Authorities. For that purpose, Regulus will promptly transfer all safety information regarding the Licensed Compounds or Products, including, if applicable,
adverse events, and drug exposure during pregnancy data that it has regarding the Licensed Compounds or Products to Sanofi for entry into the global safety database upon request from Sanofi. The timelines, format and content of such transfer shall
be agreed in the SDEA. 
 3.11.2 Regulus maintains a database that includes information regarding the safety and
tolerability of its drug compounds, individually and as a class, including information discovered during pre-clinical and clinical development (the “Regulus Database”). 

3.11.3 Safety Monitoring. In an effort to maximize understanding of the safety profile and pharmacokinetics of Regulus
compounds, after IND Approval, Sanofi will cooperate with Regulus and forward safety information to Regulus designated contact persons. This includes transmission of serious adverse events collected from Sanofi sponsored studies in a timely fashion
as agreed in the SDEA. Vice versa Regulus shall promptly inform Sanofi on any 

  
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safety issue or class effect that may come to its attention including those from other license partners to the extent Regulus is not precluded by written agreement with the applicable partner
from sharing such information with Sanofi. This includes also non clinical safety information. 
 3.11.4
Studies/Regulatory Documents. To the extent collected by Sanofi and in the form in which Sanofi uses/stores such information for its own purposes, Sanofi will provide Regulus with the results from each of the nonclinical (e.g.,
toxicology, pharmacokinetics, and safety pharmacology studies) and the clinical studies of each Licensed Compound and Product as soon as practicable following the date such information is available to Sanofi (but not later than [...***...]
days after Sanofi’s receipt of such information). The clinical results will include, but will not be limited to, subject demographics and characteristics, medical history, prior and concomitant medication usage, adverse event reports and
laboratory test results. The clinical results will be accompanied by the clinical study protocol (original and all amendments) and an annotated case report form (CRF) that identifies the variable names in the transferred data associated with each of
the data fields in the CRF. In connection with any reported serious adverse event, Sanofi will provide Regulus all serious adverse event reports (including initial, interim, follow-up, amended, and final reports) promptly following the time these
reports are submitted to Regulatory Authorities. In addition, with respect to each Licensed Compound and Product, Sanofi will provide Regulus with copies of annual safety updates filed with each IND and the safety sections of any final clinical
study reports within [...***...] days following the date such information is filed or is available to Sanofi, as applicable. Furthermore, Sanofi will promptly provide Regulus with any supporting data and answer any follow-up questions
reasonably requested by Regulus. 
 3.11.5 Confidentiality. All such information disclosed by Sanofi to Regulus
will be Sanofi Confidential Information; provided, however, that Regulus may disclose any such Sanofi Confidential Information to Regulus’ other partners pursuant to ARTICLE 7 below if such information is regarding class generic
properties of microRNA Compounds, and/or any Third Party, in each case, so long as Regulus does not disclose the identity of the Product, or Sanofi. 
 3.11.6 Contacts. Sanofi will deliver all such information to Regulus for the Regulus Database to 3545 John Hopkins Court, San Diego, California 92121-1121, Attention: Chief Medical Officer
(or to such other address/contact designated in writing by Regulus). 
 ARTICLE 4 

MANUFACTURING 
 Section 4.1 Supply of microRNA Compound for Research Program. Regulus agrees to manufacture and supply all microRNA Compounds for use in support of the Research Program until the filing of an
IND. Regulus will bear its own costs for the manufacture of all microRNA Compound needed for research until the filing of an IND. For clarity, Regulus will not be required to manufacture and supply API or drug product for any human clinical trials.

 Section 4.2 Clinical and Commercial Manufacturing and Supply of Licensed Compound and Product. 

  
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 4.2.1 Product Manufacturing Responsibility. Except as otherwise provided in this
Agreement, the Parties acknowledge and agree that Sanofi will be solely responsible for the manufacturing of Licensed Compound and Product for all clinical trials and commercial supply, including management of the overall manufacturing strategy and
tactics, formulation, internal or contract manufacturer selection for API and finished Product, associated audits, stability testing, pricing, relationship with contract manufacturer(s) and any work proposals or contract negotiations or contracts
themselves. 
 4.2.2 Supply of Finished Drug Product. Except as otherwise specified in the R&D Plan, the Parties
acknowledge and agree that Sanofi will be solely responsible for the manufacturing, stability testing and supply of finished drug Product. 
 Section 4.3 Transfer of Manufacturing Technology and Assistance. Regulus shall disclose (and provide copies, as applicable) to either Sanofi or a Third Party manufacturer designated by Sanofi
all Manufacturing Technology that is required for the manufacture (including the development of the manufacturing process) of the Licensed Compounds and Products and is reasonably necessary or useful to enable Sanofi or such Third Party manufacturer
(as appropriate) to manufacture such Products. The steps, planning and obligations of the Parties regarding the transfer of the Manufacturing Technology for each Product (for both the Licensed Compound and the Product) will be set forth in a
“Technology Transfer Master Plan API” to be executed between the Parties promptly after the JSC decides such transfer is necessary. Upon request, Regulus will at all times use diligent efforts to provide Sanofi with any additional
information or on-site support as may be required by Sanofi and its Affiliates in connection with the transfer of the Manufacturing Technology. Sanofi shall reimburse Regulus for any on-site support rendered at the FTE-Day Rate per FTE-day, provided
further Regulus shall in no event be obliged to provide more than [...***...] in total, unless the Parties otherwise agree in writing. For purposes of this Agreement “Manufacturing Technology” shall mean the Know-How
Controlled by Regulus that is reasonably available and reasonably necessary for the Manufacture (including formulation, processing, filling and packaging) of Licensed Compounds and Products. Sanofi and its Third Party manufacturer may only use the
Manufacturing Technology only in support of its licenses under Section 2.1 of this Agreement and will not use the Manufacturing Technology in connection with any other compound or product. Sanofi will be responsible and liable to Regulus for
any practice of the Manufacturing Technology by Sanofi’s Third Party manufacturer that breaches this Section 4.3. 

ARTICLE 5 

DEVELOPMENT & COMMERCIALIZATION 
 Section 5.1 Development, Commercialization and Regulatory Responsibilities. Other than Regulus’ responsibilities under the R&D Plan (including but not limited to preparing and filing
the IND for each Licensed Compound and Product), Sanofi will have sole responsibility, including without limitation sole responsibility for all funding, resourcing and decision-making, for all Development and Commercialization with respect to the
Licensed Compounds and Products after IND Approval. Sanofi hereby assumes all regulatory responsibilities in connection with Licensed Compounds and Products after IND Approval, including sole responsibility for all Regulatory Documentation and for
obtaining all Approvals. 

  
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Sanofi will comply with all Applicable Laws in connection with the Development and Commercialization of Licensed Compounds and Products. Sanofi (by itself or through its Affiliates, sublicensees,
(sub)contractors or agents, as applicable) will achieve Initiation of first Phase 1 Trial as soon as practicable following IND Approval for each Licensed Compound and will use Commercially Reasonable Efforts to Develop and Commercialize at least one
Licensed Compound or Product for each Collaboration Target. Regulus will make all IND filings under the Research Plan in Regulus’ name. Once Sanofi pays Regulus the applicable milestone payment under Section 6.4.1 for IND Approval, Sanofi
will own all INDs, NDAs, MAAs and other regulatory filings and Approvals for Products, subject to Regulus reversion rights under ARTICLE 10. 
 Section 5.2 Reports by Sanofi after the Research Term. After the Research Term with respect to any Licensed Compound or Product that Sanofi is Developing, Sanofi will provide a
[...***...] report to Regulus summarizing Sanofi’s activities over the past year with respect to the identified Licensed Compound or Product and an appropriate number of representatives from each Party will meet at least once every year
to review Development activities. Sanofi will consider Regulus’ input regarding such activities. The reports provided by Sanofi under this Section 5.2 will contain sufficient information to allow Regulus to reasonably determine whether
Sanofi is in compliance with its obligations to use Commercially Reasonable Efforts under Section 5.1. 

Section 5.3 Product Development Plans; Integrated Product Plans. For each Product that Sanofi is clinically developing under
this Agreement, Sanofi will prepare a development plan outlining key aspects of the clinical development of such Product through Approval. Each development plan will contain information customarily contained in Sanofi’s development plans for
its similar products at similar stages of development (each a “Product Development Plan”). In addition, prior to the launch of a Product, Sanofi will prepare a global integrated Product plan outlining the key aspects of
market launch and commercialization (the “Integrated Product Plan” or “IPP”). Sanofi will prepare each IPP at the same time and containing information and target markets as customarily contained in
Sanofi’s Commercialization plans for its similar products at similar stages of development. Each Product Development Plan and IPP will be updated annually by Sanofi. Sanofi will provide to Regulus a copy of the final draft of the Product
Development Plans and IPPs (original and updates) for each of the U.S., each Major European Country and Japan, if available. Such copies of Product Development Plans and IPPs provided to Regulus may be redacted to the extent necessary to preserve
the confidentiality of Sanofi confidential information related to products that are not Products. Sanofi and Regulus will meet on a yearly basis to discuss the draft of each Product Development Plan and IPP and Sanofi will consider, in its sole
discretion, any proposals and comments made by Regulus for incorporation in the final Product Development Plan or IPP (as the case may be). 
 Section 5.4 Class Generic Claims. To the extent Sanofi intends to make any claims in a Product label that are class generic to microRNA Compounds, Sanofi will provide such claims to Regulus in
advance and will consider, in its sole discretion, any proposals and comments made by Regulus. 

  
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 ARTICLE 6 
 FINANCIAL PROVISIONS 
 Section 6.1 Up-Front Payment. In
consideration for the licenses and other rights granted under this Agreement Sanofi will pay Regulus an irrevocable, non-creditable and nonrefundable technology access fee equal to $25,000,000 ($[...***...] of which Regulus is allocating to
the access to Mir-21 in the detailed amounts set forth on APPENDIX 9, and $[...***...] of which Regulus is allocating to the rest of the Research Program in the detailed amounts set forth on APPENDIX
9). Regulus shall send Sanofi separate invoices pursuant to Section 6.13 on or after the Effective Date for such $[...***...] payment and such $[...***...] payment, and Sanofi shall pay such amounts no later than
[...***...] Business Days following receipt of such invoices. The Parties hereby agree that the payments contemplated by this Section 6.1 have been made prior to the Effective Amendment Date and that, as of the Effective Amendment Date,
neither Party shall owe any obligation to the other Party under this Section 6.1. 
 Section 6.2 Research Program
Funding. Sanofi will provide Research Program funding to Regulus as set forth in Section 3.5.1. 
 Section 6.3
Target Designation Milestone. For each Collaboration Target (other than Mir-21) designated by Sanofi under Section 3.6, Sanofi will pay Regulus an irrevocable, non-creditable, and nonrefundable milestone payment equal to $[...***...]
within 10 Business Days after receipt of invoice from Regulus following such designation. For purposes of clarity, Sanofi will not have to pay an additional target designation milestone under this Section 6.3 for a replacement Collaboration
Target under Section 3.6.2. 
 Section 6.4 Milestone Payments by Sanofi. Sanofi will give Regulus written
notice within [...***...] Business Days of the first achievement of each Milestone Event provided in Table 1; provided Regulus will notify Sanofi regarding IND Approval for each Licensed Compound. After receiving such written notice,
Regulus shall submit an invoice to Sanofi for the amount of such milestone payment, and Sanofi will pay Regulus the applicable milestone payment within [...***...] days after receipt of an invoice from Regulus following achievement of the
applicable milestone event. 
 6.4.1 Development/Approval Milestones. 

(a) For each Collaboration Target (other than Mir-21), the milestone payments by Sanofi to Regulus under Column 1 of Table 1
below will be triggered by the first achievement of the specified milestone events by Sanofi, its sublicensees or their respective Affiliates for the first Licensed Compound or Product that targets or mimics such Collaboration Target to achieve the
specified milestone event. 
 (b) The milestone payments under Column 2 of Table 1 below will be payable as set forth
below for the first achievement of the specified milestone events by Sanofi, its sublicensees or their Affiliates for the first Mir-21 Compound or Mir-21 Product to achieve the specified milestone event. 

  
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 Table 1 

 

					
	 	  	Column 1	 	Column 2
	 Milestone Event
	  	Payment for First
Licensed Compound Per
Collaboration Target	 	Payment for First
Mir-21 Compound
			
	 1. IND Approval
	  	[...***...]	 	[...***...]
	 2. [...***...]
	  	[...***...]	 	[...***...]
	 3. [...***...]
	  	[...***...]	 	[...***...]
	 4. [...***...]
	  	[...***...]	 	[...***...]
	 5. [...***...]
	  	[...***...]	 	[...***...]
	 6. [...***...]
	  	[...***...]	 	[...***...]

 (c) In addition, on a Collaboration Target-by-Collaboration Target basis, after the first
achievement of milestone event [...***...] in Table 1 above by the first Licensed Compound or Product associated with a Collaboration Target to achieve such milestone event for any Indication, if a Licensed Compound or Product for such
Collaboration Target (whether the same or a different Licensed Compound or Product) subsequently achieves such milestone event(s) for any additional Indication(s) (each, an “Additional Indication”), then Sanofi will promptly
notify Regulus and will pay Regulus an additional milestone payment in an amount equal to [...***...]% of the applicable milestone payment(s) set forth in Column 1 or Column 2 (as applicable) of Table 1 above for the achievement of such
milestone event(s) by such Licensed Compound or Product for each Additional Indication (each, an “Additional Indication Milestone Payment”). 
 (d) If a Licensed Compound or Product for a Collaboration Target fails in development and is replaced by Sanofi with a back-up Licensed Compound or Product targeting the same Collaboration Target,
with respect to any milestone payments previously paid with respect to such failed Licensed Compound or Product, Sanofi will not have to pay the same milestone with respect to the corresponding back-up Licensed Compound or Product, and Sanofi will
notify Regulus in writing of the selection of the back-up Licensed Compound or Product. All milestone payments due will be payable one time only per Licensed Compound or Product for each Indication. 

(e) Any Licensed Compound or Product that targets or mimics a Collaboration Target that is a Regulus Target shall be deemed a
Mir-21 Compound or Mir-21 Product for the purposes of determining the milestone payments due to Regulus under this Section 6.4.1. 
 6.4.2 Sales Milestones. For each Collaboration Target, the milestone payments under Table 2 below will be payable by Sanofi to Regulus for the first achievement of the specified milestone events by
Sanofi, its sublicensees or their Affiliates for (i) the first Licensed Compound or Product that targets or mimics such Collaboration Target to achieve the specified milestone event; and (ii) first Mir-21 Compounds or Mir-21 Products to
achieve the specified milestone event. 

  
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 Table 2 

 

			
	 Milestone Event
	  	Milestone Payment
		
	 1. [...***...]
	  	[...***...]
	 2. [...***...]
	  	[...***...]

 Section 6.5 Royalty Payments by Sanofi. Subject to the other provisions of this Agreement,
Sanofi will pay to Regulus royalties on Net Sales of each Product at the applicable rate(s) set forth under Column 1 of Table 3 below if such Product is not a Mir-21 Product; and at the applicable rate(s) set forth under Column 2 of Table 3 below if
such Product is a Mir-21 Product. The royalty rate payable with respect to each particular Product will be based on the level of annual worldwide Net Sales of such Product in a given Calendar Year period by Sanofi, its Affiliates and sublicensees,
with the royalty rate tiered based upon the level of such worldwide Net Sales in such Calendar Year period of such Product as set forth in the table below. 
 Table 3 
  

					
	 	  	Column 1	 	Column 2
	 Annual Worldwide Net Sales
	  	Royalty Rate
Product	 	Royalty Rate
Mir-21 Product
	 For the portion that is less than or equal to $[...***...]
	  	[...***...]	 	[...***...]
	 [...***...]
	  	[...***...]	 	[...***...]
	 [...***...]
	  	[...***...]	 	[...***...]

 For example, in the instance of a full Calendar Year, if annual Net Sales of a Mir-21 Product in such Calendar Year
worldwide are $[...***...], the royalty due will be [...***...]. 
 Any Product that targets or mimics a Collaboration Target that
is a Regulus Target shall be deemed a Mir-21 Product for the purposes of determining the royalty due to Regulus under this Section 6.5. 
 Section 6.6 Existing Third Party Payment Obligations. 
 6.6.1
Existing Regulus Agreements. Sanofi acknowledges that certain of the Regulus Technology Controlled by Regulus as of the Effective Date were in-licensed, or otherwise acquired by Regulus, from Third Parties under the Existing Regulus Agreements,
and that Regulus is obligated to pay In-License Royalties and/or In-License Milestones to the Licensor(s) under such Existing Regulus Agreements as a result of the Development or Commercialization of Products by Sanofi or any of its Affiliates or
sublicensees to the extent that such Products are covered by the applicable Third Party Patents. The Parties acknowledge and agree that Regulus will be responsible for paying [...***...]% of the In-License Royalties, In-License


  
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Milestones and Other In-License Payments that become due to the Licensor(s) under the Existing Regulus Agreements. 
 6.6.2 Existing Sanofi Agreements. The Parties acknowledge and agree that, if and to the extent that there are any Existing Sanofi Agreements, Sanofi will be responsible for paying
[...***...]% of the In-License Royalties, In-License Milestones and Other In-License Payments that become due to the Licensor(s) under such Existing Sanofi Agreements, and [...***...] of such payments will be creditable against any
payment due to Regulus hereunder. 
 Section 6.7 Future Third Party Agreements. 

6.7.1 Identification of Necessary Patents. Subject to Section 6.7.5, if, after the Effective Date, a Party identifies any
Patent that: 
 (a) is not Controlled by either Party; 

(b) covers (i) the [...***...] thereof (each, a “Target Invention”), (ii) the
[...***...] (each, a “Compound Invention”), (iii) a [...***...] (each, a “Method Invention”), or (iv) [...***...] that is necessary to [...***...] to the
[...***...] in order to [...***...], excluding [...***...] (each, a “Formulation Invention”); and 
 (c) such Party believes in good faith is, or is likely to be, necessary for the Development or Commercialization of a Product; 
 then, such Party will inform the other Party thereof, and the Parties (via the JSC for so long as the JSC is in place) shall promptly confer with each other, and attempt in good faith to reach consensus
regarding, as to whether in-licensing or acquiring other rights to such Patent is, or is likely to be, necessary for the Development or Commercialization of a Product. [...***...] with respect to either or both Parties. The [...***...]
as well as [...***...]. The Parties will initially [...***...] the [...***...], provided that promptly after the [...***...], the Party whose [...***...] the other Party an [...***...]


  
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[...***...] of the [...***...] (such that the [...***...] to the [...***...] the other Party), and each Party [...***...]. 

If the [...***...] the Party that [...***...], then such Party shall be [...***...], provided that (1) such Party
shall be responsible for [...***...] of the [...***...], (2) if such Party is Sanofi, none of such payments will be creditable against any payment due to Regulus hereunder, and (3) if such Party is Regulus, then notwithstanding
any other provision of this Agreement to the contrary, such [...***...]. 
 6.7.2 Responsible Party. If the Parties
mutually agree, or [...***...], that in-licensing or acquiring other rights to a Patent meeting the criteria set forth in Section 6.7.1 is necessary for the Development or Commercialization of a Product (each, a “Necessary
Patent”), the Party that will be responsible for in-licensing or acquiring other rights to such Necessary Patent (the “Responsible Party”) will be determined based on whether such Necessary Patent covers a Target
Invention, a Compound Invention, a Method Invention, or a Formulation Invention, as follows: 
 Mir-21:

 [...***...] 
 [...***...] 
 [...***...] 

[...***...] 

[...***...] 
 Other Collaboration Targets: 
 [...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 
 Any
agreement entered into by a Responsible Party pursuant to this Section 6.7.2 shall be deemed a “Future Regulus Agreement” if Regulus is the Responsible Party, and a “Future Sanofi Agreement” if
Sanofi is the Responsible Party. 

  
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 6.7.3 Consultation; Cooperation. The Responsible Party will consult with the other
Party and consider in good faith the reasonable comments and suggestions of the other Party regarding the financial terms of any Future Regulus Agreement or Future Sanofi Agreement (as applicable), and in negotiating such Future Regulus Agreement or
Future Sanofi Agreement with the applicable Licensor(s) shall use commercially reasonable efforts to minimize any In-License Royalties, In-License Milestones and Other In-License Payments that (a) are to be borne, in whole or in part, by the
other Party pursuant to Section 6.8, (b) are creditable against any amounts payable to Regulus hereunder in accordance with Section 6.10.1 or Section 6.10.4, and/or (c) in the case of In-License Royalties, are to be
considered in [...***...]. Except as set forth in Section 6.7.2 or Section 6.9, Regulus will not enter any Future Regulus Agreement that would impose any additional financial obligations on Sanofi beyond those set forth in this
Agreement without first obtaining Sanofi’s prior written consent. 
 6.7.4 Copy of Agreement. Upon entering into any
Future Regulus Agreement or Future Sanofi Agreement that includes In-License Royalties, In-License Milestones and/or Other In-License Payments that (a) are to be borne, in whole or in part, by the other Party pursuant to Section 6.8,
(b) where Sanofi is the Responsible Party, are creditable against any amounts payable to Regulus hereunder in accordance with Section 6.10.1 or Section 6.10.4, and/or (c) in the case of In-License Royalties, are to be considered
in [...***...], the Responsible Party shall provide to the other Party a copy of the portion of such agreement which sets forth the relevant In-License Royalties, In-License Milestones and/or Other In-License Payments. 

6.7.5 Sanofi Sole Responsibility for [...***...] and [...***...] Technology. In the event that after the
Effective Date, Sanofi identifies any Patent not Controlled by either Party that covers any [...***...] that Sanofi determines, in its sole discretion, to be necessary for the Development or Commercialization of a Product, Sanofi shall have
the sole responsibility for in-licensing or acquiring other rights to such Patent, including sole responsibility for negotiation and execution of a license or other agreement with respect thereto. Sanofi will be solely responsible for paying 100% of
the In-License Royalties, In-License Milestones and Other In-License Payments that become due to the Licensor(s) under such agreement, and no such payments, nor any portion thereof, will be creditable against any of Sanofi’s payment obligations
to Regulus under this Agreement. 
 Section 6.8 Allocation of Payments. 

6.8.1 In-License Royalties. In-License Royalties payable to Licensors under any Future Regulus Agreement or Future Sanofi
Agreement shall be allocated between the Parties based on (a) whether the applicable Third Party Patents cover a Target Invention, a Compound Invention, a Method Invention, or a Formulation Invention, (b) the identity of the Licensor(s),
and/or (c) Indication, as follows: 

  
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 Mir-21: 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 
 Other Collaboration Targets: 
 [...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 
 6.8.2 In-License Milestones. In-License Milestones payable to Licensors under any Future Regulus Agreement or Future Sanofi Agreement shall be allocated between the Parties based on
(a) whether the applicable Third Party Patents cover a Target Invention, a Compound Invention, a Method Invention, or a Formulation Invention, (b) the identity of the Licensor(s), and/or (c) Indication, as follows: 

Mir-21: 
 [...***...] 
 [...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

  
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 Other Collaboration Targets: 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 
 6.8.3 Other In-License Payments. Other In-License Payments payable to under any Future Regulus Agreement or Future Sanofi Agreement shall be allocated between the Parties, or among the Parties and
one or more Third Parties (as applicable) based on (a) whether the applicable Third Party Patents cover a Target Invention, a Compound Invention, a Method Invention, or a Formulation Invention, (b) the identity of the Licensor(s),
(c) Indication, and/or (d) whether the applicable Third Party Patents are licensed to any Third Party(ies) as follows: 
 Mir-21: 
 [...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

  
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 Other Collaboration Targets: 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

[...***...] 

 

	*	[...***...] 

 6.8.4
Payment Process. Sanofi will directly pay to Regulus any amounts payable under a Future Regulus In-License in connection with a Product to the extent such amounts are allocated to Sanofi under this Section 6.8. Sanofi will pay directly the
applicable Third Party any amounts payable under a Future Sanofi In-License in connection with a Product; provided, to the extent any royalty payments are allocated to Regulus under this Section 6.8, Sanofi will be entitled to the
royalty reduction as further set forth in Section 6.10.1. 
 Section 6.9 New Core Technology. After the
Effective Date, Regulus may wish to in-license or acquire rights to Patents from a Third Party, which Patents, if in-licensed or acquired, would be within the scope of the definition of [...***...] Patent (“New Core
Patents”), with or without associated Know-How. In such event, Regulus shall [...***...] Sanofi’s consent, to negotiate and enter into an in-license or other agreement with the Third Party with respect to such New Core
Patents and related Know-How, if any (collectively, “New Core Technology”). In such event (and to the extent permitted by Regulus’ confidentiality agreement with the applicable Third Party), Regulus will notify Sanofi
regarding the nature of the New Core Technology and status of negotiations related to the New Core Technology through the JSC. Once Regulus and such Third Party have executed an agreement with respect to such New Core Technology (“New
Core Technology Agreement”), Regulus will offer such New Core Technology to Sanofi (including a description of the upfront and other ongoing non-royalty, non-milestone payments and, except as set forth in Section 6.9.2(b), the
royalties and milestone payments paid or potentially payable by Regulus thereunder). 
 6.9.1 In the case of any such New
Core Technology comprising a Target Invention, Compound Invention, Method Invention or Formulation Invention or patent rights claiming any of the foregoing (in each case, “Section 6.9.1 Technology”), if Sanofi wishes to
include such Section 6.9.1 Technology in the Regulus Technology licensed to Sanofi under Section 2. 1, Sanofi will notify Regulus of its desire to do so within [...***...] days after receipt of notice from Regulus, whereupon such
Section 6.9.1 Technology shall be included in the Regulus 

  
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Technology licensed to Sanofi under Section 2.1, and the upfront, royalty, milestone and other ongoing payments paid or potentially payable by Regulus under such New Core Technology
Agreement shall be [...***...] in accordance with [...***...], mutatis mutandis. If Sanofi [...***...] such notification to Regulus within such [...***...]-day period, then notwithstanding any other provision of this
Agreement to the contrary, the applicable Section 6.9.1 Technology will [...***...] the Regulus Technology licensed to Sanofi under Section 2.1. 
 6.9.2 In the case of any New Core Technology other than Section 6.9.1 Technology (“Section 6.9.2 Technology”), if Sanofi wishes to include such Section 6.9.2
Technology in the Regulus Technology licensed to Sanofi under Section 2.1, Sanofi will notify Regulus of its desire to do so within [...***...] days after receipt of notice from Regulus, whereupon the Parties will negotiate in good faith
regarding: 
 (a) a fair and commercially reasonable [...***...] (and/or among the Parties and any Regulus Third
Party sublicensee(s) of such Section 6.9.2 Technology) of upfront and other ongoing non-royalty, non-milestone payment obligations (which [...***...] of such payment obligations). As part of this [...***...], Regulus will share with
Sanofi, in reasonable detail, the assumptions and methodology Regulus used to create the [...***...]; and 
 (b)
the royalties and milestone payments to be [...***...] with respect to Licensed Compounds and Products, the Development, manufacture or Commercialization of which is within the scope of Regulus’ in-license or other rights to the
applicable Section 6.9.2 Technology. For the avoidance of doubt, Regulus will [...***...] to Sanofi the nature or amount of any of Regulus’ royalty and milestone payment obligations to such Third Party. 

If the Parties [...***...] to the [...***...] in Section 6.9.2(a) and the royalties and milestone payments to be
[...***...] as described in Section 6.9.2(b), then the applicable Section 6.9.2 Technology will be included in the Regulus Technology licensed to Sanofi under Section 2.1. If the Parties [...***...] to the foregoing, then
notwithstanding any other provision of this Agreement to the contrary, the applicable Section 6.9.2 Technology will [...***...] the Regulus Technology licensed to Sanofi under Section 2.1. For purposes of clarification, any payment
obligations [...***...] under this Section 6.9.2 will be in addition to, and will not be creditable in whole or in part against, Sanofi’s payment obligations set forth in this Agreement. 

6.9.3 In the event of a dispute between the parties as to whether a particular Patent of a Third Party constitutes a New Core
Patent, or whether any particular New Core Technology constitutes Section 6.9.1 Technology or Section 6.9.2 Technology, such dispute shall be [...***...] in accordance with the provisions of Section [...***...], mutatis
mutandis. 
 Section 6.10 Royalty Reductions; [...***...] Royalty. 

  
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 6.10.1 Reduction for Third Party Royalties. Subject to Section 6.10.3,
Sanofi’s royalty obligations under Section 6.5 above with respect to a particular Product in a particular country will be reduced by the applicable percentage (if any) of the amount of aggregate In-License Royalties paid by Sanofi to
Licensor(s) under Future Sanofi-Agreements on sales of such Product in such country for which Regulus is responsible, as set forth in Section 6.8; [...***...]. 
 6.10.2 Generic Competition. Subject to Section 6.10.3, if a Generic Product corresponding to a Product is approved for sale by the applicable Regulatory Authority and then sold in a particular
country and the Percentage Reduction of Net Sales is greater than [...***...]% for any given Calendar Quarter in such country, then the royalty rate set forth in Table 3 of Section 6.5 applicable to such Product and such country for such
Calendar Quarter will be reduced to [...***...]%;[...***...]. As used herein, the “Percentage Reduction of Net Sales” of a Product in a country for any particular Calendar Quarter means the quotient (expressed as
a percentage) obtained by dividing (A) the difference obtained by subtracting the [...***...] such applicable Calendar Quarter from the [...***...] by (B) the [...***...]. In addition, if (i) there [...***...]
Generic Product sold by a Third Party, and (ii) [...***...], then such Generic Product will [...***...] the royalty reduction under this Section 6.10.2. 
 6.10.3 [...***...] Royalties. Notwithstanding any other provision of this Agreement to the contrary (including, without limitation, Sections 6.10.1 and 6.10.2), in no event shall the
royalties payable by Sanofi to Regulus with respect to Net Sales of a particular Product in a particular country for any Calendar Quarter [...***...] the sum of: (a) [...***...], and (b) [...***...]
([...***...] Royalties”). 

  
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 6.10.4 Credit for Excess Royalties Paid by Sanofi. If Sanofi’s obligation to pay
[...***...] Royalties with respect to a Product in a country under Section 6.10.3 is triggered and, as a result, the sum of all royalties Sanofi pays to Regulus on sales of such Product in such country (the “Supported
Amount”) exceeds the amount of royalties Sanofi would, but for the operation of Section 6.10.3, otherwise be responsible under this ARTICLE 6 in connection with sales of such Product in such country (the “Base
Amount”), then Sanofi shall be entitled to credit such excess amount (i.e., the Supported Amount minus the Base Amount) against any future sales milestone payment payable by Sanofi to Regulus under Section 6.4.2,
regardless of which Product triggers such sales milestone payment obligation. 
 6.10.5 No Payments to Sanofi. For
purposes of clarification, and notwithstanding any other provision of this Agreement, in no event shall the credits to which Sanofi may be entitled under this Section 6.10 result in Regulus being obligated to make any payment to Sanofi.

 Section 6.11 Royalty Term. Royalties payable under Section 6.5 (subject to and including any applicable
reductions under Section 6.10) will be payable on a Product-by-Product and country-by-country basis from the First Commercial Sale of a Product in a country until the date that is the later of (i) 10 years after the First Commercial Sale
of such Product in such country or (ii) the expiration of the last to expire Valid Claim within the Regulus Patents which would be infringed by the sale of such Product in such country by an unauthorized party. Such period during which
royalties are payable with respect to a Product in a country, including giving effect to any applicable reductions under Section 6.10, is referred to herein as the “Royalty Term” for such Product in such country.
Notwithstanding expiration of the Royalty Term with respect to a particular Product in a country, Sanofi will continue to pay to Regulus all royalties payable by Regulus to Licensor(s) under the Existing Regulus Agreements with respect to Net Sales
of such Product in such country. 
 Section 6.12 Royalty Report and Payment. During the Royalty Term following the
First Commercial Sale of any Product, within [...***...] days after the end of each Calendar Quarter, Sanofi will provide Regulus with a royalty report for such Quarter showing, on a Product-by-Product and country-by-country basis: 

(a) the Net Sales of Products sold by Sanofi, its sublicensees and their respective Affiliates during such Calendar Quarter
reporting period; 
 (b) the royalties which will have accrued hereunder with respect to such Net Sales; 

(c) the amount of any applicable credits taken against royalties under Section 6.10.1 and the amount of any applicable
credits accrued against future sales milestone payments under Section 6.10.4; 
 (d) any adjustment for Generic
Products under Section 6.10.2; and 
 (e) any other information related to the calculation of Net Sales of Products
reasonably requested by Regulus that (i) is contained in a report and format that is regularly generated by Sanofi’s accounting department in its normal course of business and (ii) is


  
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reasonably necessary for Regulus to comply with an Existing Regulus Agreement or an Additional Regulus Third Party Agreement. 

Sanofi will keep, and will require its sublicensees and their respective Affiliates to keep, complete, true and accurate books of account
and records for the purpose of determining the payments to be made under this Agreement. Upon reasonable request by Regulus (but no more frequently than once in any [...***...]-month period), Sanofi will report to Regulus the quantity of
Product not subject to royalties distributed by Sanofi, its Affiliates or sublicensees as part of an expanded access program to include compassionate use, named patients or other similar use or as part of Phase 4 Trials or as bona fide samples. All
information disclosed by Sanofi to Regulus under this Section 6.12 will be Sanofi Confidential Information. 

Section 6.13 Manner of Payment and Exchange Rate. Except as otherwise provided in this Agreement, Regulus shall invoice
Sanofi for all milestone, royalty and other payments hereunder and Sanofi shall pay all such milestone, royalty and other payments that are due within ten (10) Business Days after the receipt of the applicable invoice. All payments to be made
by Sanofi to Regulus hereunder will be made by deposit of U.S. Dollars by wire transfer in immediately available funds in the requisite amount to such bank account Regulus may from time to time designate by notice to Sanofi. For sales that were made
in a currency other than U.S. Dollars, such amounts will be converted into U.S. Dollars using the average exchange rates as calculated and utilized by Sanofi’s group reporting system and published accounts for the applicable royalty period. All
invoices to be provided by Regulus to Sanofi under this Agreement shall include a breakdown of the goods, services and/or activities for which payment is due, as well is payment instructions and shall be sent by express courier service to:

 Sanofi 
 Direction Comptable Holding 
 54 rue la Boétie 

75008 Paris 

France 

Section 6.14 Audits, including Audits of Royalty Reports. 

6.14.1 Audits of Royalty Reports. Upon the written request of Regulus and not more than once in each Calendar Year, Sanofi will
permit an independent certified public accounting firm of nationally recognized standing selected by Regulus and reasonably acceptable to Sanofi, at Regulus’ expense to have access during normal business hours to such records of Sanofi and/or
its Affiliates as may be reasonably necessary to verify the accuracy of the royalty reports hereunder for any Calendar Year ending not more than 36 months prior to the date of such request. These audit rights (but not any obligation to pay unpaid
royalties for such periods) with respect to any Calendar Year will terminate 3 years after the end of such Calendar Year. Regulus will provide Sanofi with a copy of the accounting firm’s written report within 30 days of completion of such
report. 
 6.14.2 If such accounting firm concludes that an overpayment or underpayment was made, then the owing Party
will pay the amount due within 30 days of the date Regulus delivers to Sanofi such accounting firm’s written report so correctly concluding. Regulus will 

  
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bear the full cost of such audit unless such audit correctly discloses that the additional payment payable by Sanofi for the audited period is more than [...***...]% of the amount of the
royalties paid for that audited period, in which case Sanofi will pay the reasonable fees and expenses charged by the accounting firm. 
 6.14.3 Sanofi will use Commercially Reasonable Efforts to include in each sublicense granted by it to any sublicensee a provision requiring the sublicensee to maintain records of sales made
pursuant to such license and to grant access to such records by Sanofi’s independent accountant to the same extent and under substantially similar obligations as required of Sanofi under this Agreement. Sanofi will advise Regulus in advance of
each audit of any sublicensee with respect to Product sales. Sanofi will provide Regulus with a summary of the results received from the audit and, if Regulus so requests, a copy of the audit report with respect to Product sales. Sanofi will pay the
reasonable fees and expenses charged by the accounting firm, except that Regulus will pay for all additional services requested exclusively by Regulus from Sanofi’s independent accountant unless the audit discloses that the additional payments
payable to Regulus for the audited period differ by more than [...***...]% from the amount of the royalties otherwise paid. 
 6.14.4 All financial information subject to review under this Section or under any license agreement with a sublicensee will be Sanofi Confidential Information and will be treated in accordance
with the confidentiality provisions of this Agreement. As a condition precedent to Regulus’ audit rights under this Section, Regulus’ accounting firm will enter into a confidentiality agreement with Sanofi obligating it to treat all such
financial information in confidence pursuant to such confidentiality agreement. Regulus may provide Third Parties to which Regulus owes royalties on Products information in such audit report that are relevant and required to comply with such Third
Party’s audit rights under the applicable license agreement between Regulus and such Third Party, provided that such Third Party agrees in writing to keep such information confidential under terms no less restrictive than Regulus’
obligations of confidentiality under this Agreement. 
 Section 6.15 Taxes. 

6.15.1 Sanofi will make all payments to Regulus under this Agreement without deduction or withholding for taxes except to the
extent that any such deduction or withholding is required by Applicable Law in effect at the time of payment. 
 6.15.2
Sanofi will promptly pay on behalf of Regulus any tax required to be withheld on amounts payable under this Agreement to the appropriate governmental authority, and Sanofi will furnish Regulus with proof of payment of such tax. Any such tax
required to be withheld will be an expense of and borne by Regulus. 
 6.15.3 Sanofi and Regulus will cooperate with
respect to all documentation required by any taxing authority or reasonably requested by Sanofi to secure a reduction in the rate of applicable withholding taxes. 
 Section 6.16 Sublicenses. In the event Sanofi grants licenses or sublicenses to a sublicensee to sell Products which are subject to royalties under Section 6.5, such licenses or


  
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sublicenses will include an obligation for the sublicensee to account for and report its sales of Products on the same basis as if such sales were Net Sales by Sanofi. 

Section 6.17 Interest. If Sanofi fails to make any payment due to Regulus under this Agreement, then interest will accrue on
a daily basis at the greater of an annual rate equal to the [...***...] (or such lower interest rate to the extent necessary to comply with Applicable Law). 
 Section 6.18 Sanofi Founding Company License. Notwithstanding any other provision in this Agreement, in the event that Sanofi is granted a license (each such license a “Sanofi
Founding Company License”) pursuant to Section 15.3 of the Founding Company License Agreement (entitled “Effects of Termination”) from either of the Founding Companies, then, in addition to, and not in lieu of, any other
or remedies available to Sanofi: 
 6.18.1 [...***...] amounts payable to either of the Founding Companies pursuant
to proviso “(ii)” of the final sentence of Section 15.3, [...***...]; and 
 6.18.2 subject to
Section 6.10.3, any royalty or milestone amounts (including both sales milestones and development milestones) payable to either of the Founding Companies under any Sanofi Parent License, to the extent not [...***...] than were
Regulus’ royalty and milestone payment obligations under the Founding Company License Agreement, [...***...] under this Agreement. If royalty or milestone amounts payable by Sanofi to either of the Founding Companies under any Sanofi
Parent License [...***...] Regulus’ royalty or milestone payment obligations under the Founding Company License Agreement, Sanofi [...***...]. 
 ARTICLE 7 
 CONFIDENTIALITY; PRESS RELEASES & PUBLICATIONS

 Section 7.1 Confidentiality; Exceptions. Except to the extent expressly authorized by this Agreement or
otherwise agreed in writing, the Parties agree that, during the Term and for five (5) years thereafter, the receiving Party (the “Receiving Party”) and its Affiliates will keep
confidential and will not publish or otherwise disclose or use for any purpose other than as provided for in this Agreement any Know-How or other confidential and proprietary information and materials, patentable or otherwise, in any form (written,
oral, photographic, electronic, magnetic, or otherwise) which is disclosed to it by the other Party (the “Disclosing Party”) or its Affiliates or otherwise received or accessed by a Receiving Party in the course of performing
its obligations or exercising its rights under this Agreement, including, but not limited to, trade secrets, Know-How, inventions or discoveries, proprietary information, formulae, processes, techniques and information relating to the past, present
and future marketing, financial, and research and development activities of any product or potential product or useful technology of the Disclosing Party or its Affiliates and the pricing thereof (collectively, “Confidential


  
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Information”), except to the extent that it can be established by the Receiving Party that such Confidential Information: 

7.1.1 was in the lawful knowledge and possession of the Receiving Party or its Affiliates prior to the time it was disclosed to,
or learned by, the Receiving Party or its Affiliates, or was otherwise developed independently by the Receiving Party or its Affiliates, as evidenced by written records kept in the ordinary course of business, or other documentary proof of actual
use by the Receiving Party or its Affiliates; 
 7.1.2 was generally available to the public or otherwise part of the
public domain at the time of its disclosure to the Receiving Party or its Affiliates; 
 7.1.3 became generally available
to the public or otherwise part of the public domain after its disclosure and other than through any act or omission of the Receiving Party or its Affiliates in breach of this Agreement; or 

7.1.4 was disclosed to the Receiving Party or its Affiliates, other than under an obligation of confidentiality, by a Third Party
who had no obligation to the Disclosing Party or its Affiliates not to disclose such information to others. 

Section 7.2 Authorized Disclosure. Except as expressly provided otherwise in this Agreement, a Receiving Party or its
Affiliates may use and disclose to Third Parties Confidential Information of the Disclosing Party as follows: (i) with respect to any such disclosure of Confidential Information, under confidentiality provisions no less restrictive than those
in this Agreement, and solely in connection with the performance of its obligations or exercise of its rights granted or reserved in this Agreement (including, without limitation, the rights to Develop and Commercialize Licensed Compounds, Products,
and/or Discontinued Products, and to grant licenses and sublicenses hereunder), provided, that Confidential Information may be disclosed by a Receiving Party to a governmental entity or agency without requiring such entity or agency to enter
into a confidentiality agreement with such Receiving Party if such Receiving Party has used reasonable efforts to impose such requirement without success and disclosure to such governmental entity or agency is necessary for the performance of the
Receiving Party’s obligations hereunder; (ii) to the extent such disclosure is reasonably necessary in filing or prosecuting patent, copyright and trademark applications (subject to Section 8.6 below), complying with applicable
governmental regulations, obtaining Approvals, conducting clinical trials, marketing Products, or as otherwise required by applicable law, regulation, rule or legal process (including the rules of the SEC and any stock exchange); provided,
however, that if a Receiving Party or any of its Affiliates is required by law or regulation to make any such disclosure of a Disclosing Party’s Confidential Information it will, except where impracticable for necessary disclosures, for
example, but without limitation, in the event of a medical emergency, give reasonable advance notice to the Disclosing Party of such disclosure requirement and will use its reasonable efforts to secure confidential treatment of such Confidential
Information required to be disclosed; (iii) in communication with actual or potential lenders, arm’s-length financial investors, merger partners, acquirers, consultants, or professional advisors on a need-to-know basis, in each case under
confidentiality provisions no less restrictive than those of this Agreement; (iv) to the extent and only to the extent that such disclosure is required to comply with existing expressly stated contractual obligations owed to such Party’s
or 

  
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its Affiliates’ licensor with respect to any intellectual property licensed to the other Party under this Agreement; (v) to prosecute or defend litigation as permitted by this
Agreement; or (vi) to the extent mutually agreed to in writing by the Parties. 
 Section 7.3 Press Release;
Disclosure of Agreement. Except to the extent required to comply with applicable law, regulation, rule or legal process or as otherwise permitted in accordance with this Section 7.3, neither Party nor such Party’s Affiliates will make
any public announcements, press releases or other public disclosures concerning this Agreement or the terms or the subject matter hereof without the prior written consent of the other, which will not be unreasonably withheld. Notwithstanding the
foregoing, (a) except for scientific presentations and publications (which will be governed by Section 7.5 below) each Party or its Affiliates may, without the other Party’s approval, make disclosures pertaining solely to Products (as
to Sanofi) or Discontinued Products (as to Regulus), provided, however, that Sanofi will immediately notify (and provide as much advance notice as possible to) Regulus of any event materially related to Products (including in such notice any
disclosure of clinical data or results, material regulatory filings or Approval) so that the Parties may analyze the need for or desirability of publicly disclosing or reporting such event, any press release or other similar public communication by
Sanofi related to efficacy or safety data and/or results of a Licensed Product will be submitted to Regulus for review at least five (5) Business Days (to the extent permitted by law) in advance of such proposed public disclosure, Regulus will
have the right to expeditiously review and recommend changes to such communication and Sanofi will in good faith consider any changes that are timely recommended by Regulus and (b) to the extent information regarding this Agreement, a Licensed
Compound or Product has already been publicly disclosed, either Party (or its Affiliates) may subsequently disclose the same information to the public without the consent of the other Party. Each Party will give the other Party a reasonable
opportunity (to the extent consistent with law) to review all material filings with the SEC describing the terms of this Agreement prior to submission of such filings, and will give due consideration to any reasonable comments by the non-filing
Party relating to such filing, including without limitation the provisions of this Agreement for which confidential treatment should be sought. 
 Section 7.4 Remedies. Notwithstanding Section 12.4, each Party will be entitled to seek, in addition to any other right or remedy it may have, at law or in equity, a temporary injunction,
without the posting of any bond or other security, enjoining or restraining the other Party from any violation or threatened violation of this Article 7. 
 Section 7.5 Publications. 
 7.5.1 Prior to IND Approval. Prior
to IND Approval (and Sanofi’s payment to Regulus of the applicable milestone under Section 6.5.1) for a given Collaboration Target, Regulus may, consistent with its practice with its other compounds and products, publish and present data
regarding any such Collaboration Targets, Licensed Compounds and/or Products; provided, however, that Regulus will provide any such proposed publication to Sanofi at least 30 days prior to submission for publication or presentation. During
such 30-day period, Sanofi will have the right to review and comment on any such publications and Regulus will give due consideration to Sanofi’s requested changes. In addition, by written notice to Regulus delivered within such 30-day period,
Sanofi will have the right, in its discretion, to prohibit Regulus from 

  
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making such publication or presentation. If Sanofi does not provide such written notice prohibiting publication or presentation by the end of such 30-day period, then Sanofi will be deemed to
have consented to such publication or presentation. Notwithstanding the foregoing, Regulus may not publish or present any data or information that contains any of Sanofi’s Confidential Information without Sanofi’s prior written
consent. 
 7.5.2 After IND Approval. After IND Approval (where Sanofi has paid Regulus the applicable milestone payment
under Section 6.5.1) for a given Collaboration Target, and subject to this Section 7.5.2, Sanofi will have the right to publish summaries of results from any human clinical trials generated by Sanofi with respect to the Licensed Compounds
or Products without obtaining the consent of Regulus and, except as required under Law, Regulus may not publish any of such data, without the prior consent of Sanofi. The Parties acknowledge that scientific lead time is a key element of the value of
the Research Program and Products under this Agreement and further agree to use commercially reasonable efforts to control public scientific disclosures of the results of the research and Development activities under this Agreement (including but
not limited to any such summaries of human clinical trials data and results as required on the clinical trial registry) to prevent any potential adverse effect of any premature public disclosure of such results. The Parties will establish a
procedure for publication review and each Party will first submit to the other Party an early draft of all such publications, whether they are to be presented orally or in written form, at least 45 days prior to submission for publication including,
without limitation, to facilitate the publication of any summaries of human clinical trials data and results as required on the clinical trial registry of each respective Party. Each Party will review such proposed publication in order to avoid the
unauthorized disclosure of a Party’s Confidential Information and to preserve the patentability of inventions arising from the Research Program. If, as soon as reasonably possible, but no longer than [...***...] days following receipt of
an advance copy of a Party’s proposed publication, the other Party informs such Party that its proposed publication contains Confidential Information of the other Party, then such Party will delete such Confidential Information from its
proposed publication. In addition, if at any time during such [...***...]-day period, the other Party informs such Party that its proposed publication discloses inventions made by either Party in the course of the Research Program under this
Agreement that have not yet been protected through the filing of a patent application, or the public disclosure of such proposed publication could be expected to have a material adverse effect on any Patents or Know-How solely owned or Controlled by
such other Party, then such Party will either (a) delay such proposed publication, for up to [...***...] days from the date the other Party informed such Party of its objection to the proposed publication, to permit the timely preparation
and first filing of patent application(s) on the information involved or (b) remove the identified disclosures prior to publication. 
 Section 7.6 Acknowledgment. Unless otherwise agreed upon in writing by the Parties, each Party will acknowledge in any press release, public presentation or publication regarding a
Collaboration Target, Licensed Compound and/or Product, the other Party’s role in discovering and developing the Collaboration Target, Licensed Compound or Product, as applicable, and that such Collaboration Targets, Compounds or Products are
under license from Regulus (including, if requested by Regulus, Regulus’ stock ticker) and otherwise acknowledge the contributions from the other Party. 

  
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 ARTICLE 8 
 PATENTS 
 The provisions of this Article 8 (excluding Section 8.1) as
they relate to Regulus Patents that are licensed to Regulus under any Existing Regulus Agreement are subject in all respects to the terms of such Existing Regulus Agreement. In the event of any inconsistency between Regulus’ obligations under
any Existing Regulus Agreement and the rights conferred on Sanofi by this Article 8 (excluding Section 8.1) with respect to the Regulus Patents that are subject to such Existing Regulus, the Existing Regulus Agreement shall control, and the
provisions of this Article 8 shall, to the extent inconsistent with the Existing Regulus Agreement, be of no force or effect. 

Section 8.1 Ownership of Inventions and Patents. 
 8.1.1 Title to inventions, discoveries, improvements and other technology, whether or not patentable, conceived, made or reduced to practice in the performance of the Research Program under this
Agreement (collectively, the “Program Inventions”) and any Patents claiming such Program Inventions (“Program Patents”), are retained by the Party that is the employer of the inventor(s) (or, in the
case of consultants and (sub)contractors, the Party for which the consultant or (sub)contractor is providing its services). Each Party will ensure that every employee, consultant, and (sub)contractor employed or contracted by that Party in the
performance of the Research Program has a written obligation to assign all Know-How and Patents conceived, made or reduced to practice by each such employee, consultant, and (sub)contractor to such Party. The Parties agree that the United States
federal patent law on inventorship will determine the inventorship of any Program Invention and the names of the inventors on any Program Patent filings, whether sole or joint inventions, which arise in connection with activities conducted pursuant
to this Agreement. Sanofi will own Program Inventions invented solely by employees, consultants and/or (sub)contractors of Sanofi (the “Sanofi Inventions”) and any Patents claiming such Program Inventions (the
“Sanofi Program Patents”). Regulus will own Program Inventions invented solely by employees, consultants and/or (sub)contractors of Regulus (the “Regulus Inventions”) and any Patents claiming such
Program Inventions (the “Regulus Program Patents”). Regulus and Sanofi will own jointly such Program Inventions invented jointly by employees, consultants and/or (sub)contractors of Regulus and Sanofi (the “Joint
Inventions”) and any Patents claiming such Program Inventions (the “Joint Patents”). Regulus will promptly disclose to Sanofi any such Regulus Invention or Joint Invention, and Sanofi will promptly disclose to
Regulus any Sanofi Invention or Joint Invention, arising from or made in the performance of the Research Program and any patent or patent application claiming such Program Invention. It is understood that except as otherwise provided in this
Agreement or as the Parties may otherwise agree in writing, neither Party will have any obligation to account to the other Party for profits, or to obtain any approval of the other Party to license, assign, mortgage or exploit a Joint Invention by
reason of joint ownership of any such Joint Invention, and may otherwise undertake all activities a sole owner might undertake with respect to such inventions without the consent of and without accounting to the other joint owner, and each Party
hereby waives any right it may have under the laws of any jurisdiction to require such consent or accounting. 

  
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 8.1.2 CREATE Act. Notwithstanding anything to the contrary in this Article 8, neither
Party will have the right to make an election under the Cooperative Research and Technology Enhancement Act of 2004, 35 U.S.C. § 103(c)(2)-(c)(3) (the “CREATE Act”) when exercising its rights under this Article 8 without
the prior written consent of the other Party, which will not be unreasonably withheld, conditioned or delayed. With respect to any such permitted election, the Parties will use reasonable efforts to cooperate and coordinate their activities with
respect to any submissions, filings or other activities in support thereof. The Parties acknowledge and agree that this Agreement is a “joint research agreement” as defined in the CREATE Act. 

Section 8.2 Filing, Prosecution and Maintenance of Patents. For purposes of this Section 8.2, the terms
“prosecute,” “prosecuting” and “prosecution,” when used in reference to any Patent, shall be deemed to include, without limitation, the control of any interferences, reissue proceedings, oppositions and reexaminations
with respect to such Patent. 
 8.2.1 Product Specific Patents. 

(a) Before IND Approval. On a Collaboration Target-by Collaboration Target basis, for Product Specific Patents filed prior to IND
Approval for a Licensed Compound that targets or mimics (as applicable) a particular Collaboration Target, Regulus will be responsible for the preparation, filing, prosecution and maintenance of such Product Specific Patents (including Product
Specific Patents that are Joint Patents) directed to such Collaboration Target or to Licensed Compounds or Products that target or mimic (as applicable) such Collaboration Target. Regulus will use Commercially Reasonable Efforts to prepare, file,
prosecute and maintain such Product Specific Patents in at least the countries listed in APPENDIX 7 (each, a “Listed Country”), at Regulus’ expense; provided, however, that if the applicable
patent office in any Listed Country, other than [...***...] and [...***...], requires [...***...] of patent applications [...***...], Sanofi shall reimburse Regulus for costs incurred by Regulus for [...***...] of
Product Specific Patents [...***...]. If Sanofi requests in writing that Regulus prepare, file, prosecute and maintain any Product Specific Patent in any country that is not a Listed Country (each, a “Sanofi Nominated
Country”), Regulus will use Commercially Reasonable Efforts to prepare, file, prosecute and maintain such Product Specific Patent in such Sanofi Nominated Country, at Sanofi’s expense, provided, however, that if Sanofi is
not the sole licensee or sublicensee of Regulus under such Product Specific Patent, Regulus will be responsible for such expenses and Sanofi will reimburse Regulus for the amount that is equal to the total of such expenses divided by the number of
licensee(s) or sublicense(s) under such product specific patent (such number to also include Regulus). 
 (b) After IND
Approval. On a Collaboration Target-by-Collaboration Target basis, for Product Specific Patents filed after IND Approval for a Licensed Compound that targets or mimics (as applicable) a particular Collaboration Target, Sanofi will be responsible
for the preparation, filing, prosecution and maintenance of such Product Specific Patents (including Product Specific Patents that are Joint Patents) directed to such Collaboration Target or to Licensed Compounds or Products that target or mimic (as
applicable) such Collaboration Target, at Sanofi’s expense; provided, however, that if Sanofi is not the sole licensee or sublicensee of Regulus under such Product Specific Patent, Regulus will be


  
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responsible for such expenses and Sanofi will reimburse Regulus for the amount that is equal to the total of such expenses divided by the number of licensee(s) or sublicense(s) under such product
specific patent (such number to also include Regulus). 
 (c) Disclosure; Cooperation. The Party responsible for
preparing, filing, prosecuting and maintaining any Product Specific Patent (including any Product Specific Patent that is a Joint Patent) under Section 8.2.1(a) or Section 8.2.1(b) above (the “Lead Party”), or its
outside counsel, will provide the other Party with (i) a reasonably detailed monthly update of the filing, prosecution and maintenance status for such Product Specific Patent and (ii) any further information reasonably requested by the
other Party from time to time regarding such Product Specific Patent; provided, however, that if such Product Specific Patent is licensed to Regulus by a Third Party, Regulus will not be obligated to make disclosure of information regarding
such Product Specific Patent to the extent that such disclosure would constitute a breach of Regulus’ confidentiality obligations to the Third Party licensor. Regulus will consider in good faith, and give effect to, all reasonable requests or
recommendations of Sanofi regarding the preparation, filing, prosecution and maintenance of Product Specific Patents. Sanofi will consider in good faith all reasonable requests or recommendations of Regulus regarding the preparation, filing,
prosecution and maintenance of Product Specific Patents. 
 (d) Election Not to File, Prosecute, or Maintain Product
Specific Patents. In the event that the Lead Party decides not to pursue or continue the filing, prosecution or maintenance of any Product Specific Patent in any country, the Lead Party, or its outside counsel, will provide the other Party with
written notice of such decision at least 60 days in advance of any relevant filing, prosecution or maintenance deadline, and the other Party will provide the Lead Party with prompt notice as to whether the other Party desires to assume
responsibility and costs for such filing, prosecution or maintenance of such Product Specific Patent. The Lead Party will not knowingly permit any such Product Specific Patent to be abandoned in any Listed Country (or, in the case of Regulus, any
Sanofi Nominated Country for which Sanofi is bearing the expense of preparation, filing, prosecution and maintenance of Product Specific Patents), or elect not to file a new patent application claiming priority to a patent application within the
Product Specific Patents either before such patent application’s issuance or within the time period required for the filing of an international (i.e., Patent Cooperation Treaty), regional (including European Patent Office) or national
application, without the other Party’s written consent or without the other Party otherwise first being given an opportunity to assume full responsibility (at the other Party’s expense) for the continued prosecution and maintenance of such
Product Specific Patents, or the filing of such new patent application. In the event that the other Party assumes responsibility for the preparation, filing, prosecution or maintenance of any patent or patent application as set forth above, the
other Party will not be liable to the Lead Party in any way with respect to its handling of, or the results obtained from, the filing, prosecution, issuance, extension or maintenance of such application or any resulting patent or any failure by it
to so file, prosecute, extend or maintain. In the event that Sanofi assumes responsibility for the preparation, filing, prosecution or maintenance of any such Product Specific Patent as set forth above, Regulus will assign such Product Specific
Patent to Sanofi, for no additional consideration, and such Product Specific Patent (if later granted) will be disregarded for the purposes of calculating the Royalty Term under Section 6.11. 

  
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 8.2.2 Regulus Core Technology Patents Other Than Joint Patents. Regulus (or its Third
Party licensors of Regulus Core Technology Patents, as applicable) will be solely responsible for the preparation, filing, prosecution and maintenance of Regulus Core Technology Patents (other than Joint Patents that are Regulus Core Technology
Patents), at Regulus’ sole expense. At Sanofi’s reasonable request from time to time, Regulus, or its outside counsel, will promptly provide Sanofi with an update of the filing, prosecution and maintenance status for each of such Regulus
Core Technology Patents, including without limitation an update of APPENDIX 3. 
 8.2.3 Joint Core
Technology Patents. This Section 8.2.3 will apply only to: (i) Regulus Core Technology Patents that are Joint Patents (each, a “Joint Core Technology Patent”); and (ii) any Joint Invention that is not
claimed by any patent application in a country, provided that if a patent application claiming such Joint Invention were filed in such country, such patent application would be a Joint Core Technology Patent (such Joint Invention, a
“Joint Core Technology Invention”). 
 (a) Regulus First Right to File, Prosecute and Maintain.
Regulus will have the first right to prepare, file, prosecute and maintain any new patent application claiming a Joint Core Technology Invention, at Regulus’ expense. Regulus shall consult with Sanofi as to the preparation, filing, prosecution
and maintenance of Joint Core Technology Patents and draft patent applications claiming Joint Core Technology Inventions reasonably prior to any deadline or action with any patent office, shall furnish to Sanofi copies of all relevant documents
reasonably in advance of such consultation, and shall consider in good faith the reasonable comments and suggestions of Sanofi. Regulus, or its outside counsel, will provide Sanofi with an update of the filing, prosecution and maintenance status for
each Joint Core Technology Patent on a periodic basis, and will provide to Sanofi copies of any papers relating to the filing, prosecution and maintenance of such Joint Core Technology Patents promptly upon their being filed or received. 

(b) Disclosure; Cooperation. Regulus or its outside counsel, will provide Sanofi with (i) a reasonably detailed monthly
update of the filing, prosecution and maintenance status for such Joint Core Technology Patent and (ii) any further information reasonably requested by Sanofi from time to time regarding such Joint Core Technology Patent. Regulus will consider
in good faith all reasonable requests or recommendations of Sanofi regarding the preparation, filing, prosecution and maintenance of Joint Core Technology Patents. 
 (c) Election Not to File, Prosecute, or Maintain Joint Core Technology Patents. In the event that Regulus decides not to pursue or continue the filing, prosecution or maintenance of any Joint Core
Technology Patent in any country, Regulus, or its outside counsel, will provide Sanofi with written notice of such decision at least 60 days in advance of any relevant filing, prosecution or maintenance deadline, and Sanofi will provide Regulus with
prompt notice as to whether Sanofi desires to assume responsibility and costs for such filing, prosecution or maintenance of such Joint Core Technology Patent. Regulus will not knowingly permit any such Joint Core Technology Patent to be abandoned,
or elect not to file a new patent application claiming priority to a patent application within the Joint Core Technology Patents either before such patent application’s issuance or within the time period required for the filing of an
international (i.e., Patent Cooperation Treaty), regional (including European Patent 

  
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Office) or national application, without Sanofi’s written consent or without Sanofi otherwise first being given an opportunity to assume full responsibility (at Sanofi’s expense) for
the continued prosecution and maintenance of such Joint Core Technology Patent, or the filing of such new patent application. In the event that Sanofi assumes responsibility for the preparation, filing, prosecution or maintenance of any Joint Core
Technology Patent as set forth above, such Joint Core Technology Patent (if later granted) will be disregarded for the purposes of calculating the Royalty Term under Section 6.7, provided that Regulus shall retain its joint ownership interest
in such Joint Core Technology Patent. 
 8.2.4 Joint Patents Other Than Joint Core Technology Patents and Product Specific
Patents. This Section 8.2.4 will apply only to: (i) Joint Patents that are neither Joint Core Technology Patents nor Product Specific Patents (each, an “Other Joint Patent”); and (ii) any Joint Invention
that is not claimed by any patent application in a country, provided that if a patent application claiming such Joint Invention were filed in such country, such patent application would be neither a Joint Core Technology Patent nor a Product
Specific Patent (such Joint Invention, an “Other Joint Invention”). 
 (a) Sanofi First Right to
File, Prosecute and Maintain. Sanofi will have the first right to prepare, file, prosecute and maintain any new patent application claiming an Other Joint Invention, at Sanofi’s expense. Sanofi shall consult with Regulus as to the
preparation, filing, prosecution and maintenance of Other Joint Patents and draft patent applications claiming Other Joint Inventions reasonably prior to any deadline or action with any patent office, shall furnish to Regulus copies of all relevant
documents reasonably in advance of such consultation, and shall consider in good faith the reasonable comments and suggestions of Regulus. Sanofi, or its outside counsel, will provide Regulus with an update of the filing, prosecution and maintenance
status for each Other Joint Patent on a periodic basis, and will provide to Regulus copies of any papers relating to the filing, prosecution and maintenance of such Other Joint Patents promptly upon their being filed or received. 

(b) Election Not to File, Prosecute, or Maintain Other Joint Patents. In the event that Sanofi decides not to pursue or continue
the filing, prosecution or maintenance of any Other Joint Patent in any country, Sanofi, or its outside counsel, will provide Regulus with written notice of such decision at least 60 days in advance of any relevant filing, prosecution or maintenance
deadline, and Regulus will provide Sanofi with prompt notice as to whether Regulus desires to assume responsibility and costs for such filing, prosecution or maintenance of such Other Joint Patent. Sanofi will not knowingly permit any such Other
Joint Patent to be abandoned, or elect not to file a new patent application claiming priority to a patent application within the Other Joint Patents either before such patent application’s issuance or within the time period required for the
filing of an international (i.e., Patent Cooperation Treaty), regional (including European Patent Office) or national application, without Regulus’ written consent or without Regulus otherwise first being given an opportunity to assume full
responsibility (at Regulus’ expense) for the continued prosecution and maintenance of such Other Joint Patent, or the filing of such new patent application. In the event that Regulus assumes responsibility for the preparation, filing,
prosecution or maintenance of any patent or patent application as set forth above, Regulus will not be liable to Sanofi in any way with respect to its handling of, or the results obtained from, the filing, prosecution, issuance, extension or


  
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maintenance of such application or any resulting patent or any failure by it to so file, prosecute, extend or maintain. 
 8.2.5 Cooperation. Each Party agrees to cooperate fully in the preparation, filing, prosecution and maintenance of Patents pursuant to this Section 8.2. Such cooperation includes, but is not
limited to: (a) executing all papers and instruments, or requiring its employees or contractors, to execute such papers and instruments, so as to enable the other Party to exercise its rights and perform its obligations under this
Section 8.2; and (b) promptly informing the other Party of any matters coming to such Party’s attention that may affect the preparation, filing, prosecution or maintenance of any such patent applications. 

Section 8.3 Patent Term Extension. Regulus and Sanofi will each cooperate with one another and will use Commercially
Reasonable Efforts in obtaining patent term restorations and/or extensions (including without limitation, any pediatric exclusivity extensions as may be available) or supplemental protection certificates or their equivalents in any country with
respect to patent rights covering those Products licensed by Sanofi hereunder. If elections with respect to obtaining such patent term extensions or supplemental protection are to be made, Sanofi will have the right to make such election,
provided that (i) such election will be made in accordance with applicable Law so as to maximize the period of marketing exclusivity for the Product, and (ii) Sanofi may not elect to extend a Regulus Core Technology Patent (other
than a Joint Core Technology Patent) under this Section 8.3 without Regulus’ prior written consent. 

Section 8.4 Enforcement of Patents 
 8.4.1 Product Specific Patents. 
 (a) Enforcement by Sanofi. In the
event that Regulus or Sanofi becomes aware of a suspected infringement of any Product Specific Patent, or any such Product Specific Patent is challenged in any action or proceeding (other than any interferences, reissue proceedings, oppositions or
reexaminations, which are addressed above), such Party will notify the other Party promptly, and following such notification, the Parties will confer and determine an appropriate course of action in response to such suspected infringement or action
or proceeding. Sanofi will have the right, but will not be obligated, to defend any such action or proceeding or bring an infringement action with respect to such suspected infringement at its own expense, in its own name and entirely under its own
direction and control, or settle any such action, proceeding or dispute by license (to the extent such sublicense is permitted under this Agreement). Regulus will reasonably assist Sanofi in any action or proceeding being defended or prosecuted if
so requested, and will lend its name to such actions or proceedings if reasonably requested by Sanofi or required by Applicable Law. Sanofi will reimburse Regulus for the documented out-of-pocket costs Regulus reasonably incurs in providing such
assistance as specifically requested in writing by Sanofi. In the event Regulus is a required party to the proceeding or action, Regulus will have the right to be represented by its own counsel (such selection to be subject to Sanofi’s
approval, such approval not to be unreasonably withheld), and Sanofi will reimburse Regulus for the documented external costs Regulus reasonably incurs that are reasonably related to the proceeding or action, including attorneys fees,
provided that Sanofi will retain overall responsibility for the prosecution of such action or proceeding in such event. In the event that Regulus is not a necessary party to the proceeding or action, Regulus will have


  
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the right to participate and be represented in any such suit by its own counsel at its own expense, provided that Sanofi will retain overall responsibility for the prosecution of such
action or proceedings in such event. Sanofi may not enter any settlement of any such action or proceeding which restricts the scope, or adversely affects the enforceability, of a Product Specific Patent, or which could be reasonably expected to have
a material adverse financial impact on Regulus, without Regulus’ prior written consent, which consent will not be unreasonably withheld, conditioned or delayed. 
 (b) Enforcement by Regulus. If Sanofi elects not to settle, defend or bring any action for infringement described in Section 8.4.1(a) and so notifies Regulus, including following any request
by Regulus to do so, then Regulus may defend or bring such action at its own expense, in its own name, provided however that, Regulus agrees not to so settle, defend or bring any action for infringement of a Product Specific Patent Right upon
Sanofi’s request based on Sanofi’s good faith reasonable determination, the basis for which will be provided to Regulus, that it is not in the best interest of the Parties to so settle, defend or bring such action for infringement. In the
case where Regulus proceeds to settle, defend or bring an action for such infringement, the following will apply: (i) Sanofi will reasonably assist Regulus in any action or proceeding being defended or prosecuted if so requested, and will lend
its name to such actions or proceedings if requested by Regulus or required by Applicable Law; (ii) Regulus will reimburse Sanofi for the documented external costs Sanofi reasonably incurs, including attorneys fees, in providing such assistance
as specifically requested in writing by Regulus; (iii) Sanofi will have the right to participate and be represented in any such suit by its own counsel at its own expense, provided that Regulus will retain overall responsibility for the
prosecution of such suit or proceedings in such event; and (iv) Regulus may not enter any settlement of any action or proceeding defended or brought by Regulus with respect to a Product Specific Patent, which restricts the scope, or adversely
affects the enforceability, of a Product Specific Patent, or which could be reasonably expected to have a material adverse financial impact on Sanofi without Sanofi’s prior written consent, which consent will not be unreasonably withheld,
conditioned or delayed. 
 (c) Withdrawal. If either Party brings an action or proceeding under this Section 8.4.1
and subsequently ceases to pursue or withdraws from such action or proceeding, it will promptly notify the other Party and the other Party may substitute itself for the withdrawing Party and pursue such action or proceeding in accordance with the
terms of this Section 8.4.1 (including but not limited to the proviso in the first sentence of Section 8.4.1(b)). 

(d) Damages. In the event that either Party exercises the rights conferred above in this Section 8.4.1 and recovers any
damages or other sums in such action, suit or proceeding or in settlement thereof, such damages or other sums recovered will first be applied to all out-of-pocket costs and expenses incurred by the Party which initiated such action, suit or
proceeding, including, without limitation, attorneys fees, and second to any out-of-pocket costs and expenses incurred by the other Party and not previously reimbursed by the Party which initiated such action, suit or proceeding according to this
Section 8.4.1. Any remaining amounts will: (i) if recovered by Sanofi, be divided as follows: (A) as to ordinary damages based on lost sales or profit, Sanofi will retain such funds and such funds will be treated as Net Sales and
royalties will be payable by Sanofi to Regulus with respect to such Net Sales in accordance with Section 6.5 of this Agreement and (B) as to special or punitive damages, Sanofi will receive


  
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[...***...]% of the amount of such special or punitive damages and Regulus will receive [...***...]% of the amount of such special or punitive damages; or (ii) if recovered by
Regulus, [...***...]. 
 8.4.2 Regulus Core Technology Patents Other Than Joint Core Technology Patents. Regulus
will have the sole right to enforce Regulus Core Technology Patents (other than Joint Core Technology Patents) and to defend Regulus Core Technology Patents (other than Joint Core Technology Patents) against challenge in any action or proceeding
(other than any interferences, reissue proceedings, oppositions or reexaminations, which are addressed above). In the event of suspected infringement of a Regulus Core Technology Patent (other than a Joint Core Technology Patent) by a Third Party in
a country, wherein (a) the suspected infringing activity competes with a Product being commercialized by or on behalf of Sanofi in such country, and (b) no other Patent Controlled by Sanofi (whether by license under this Agreement or
otherwise) is infringed or suspected to be infringed by the suspected infringing activity, Section [...***...] to apply to such Product in such country (with the suspected infringing product [...***...]), unless Regulus permits Sanofi to
enforce the applicable Regulus Core Technology Patent against such Third Party. 
 8.4.3 Joint Core Technology Patents.
In the event of suspected infringement of a Joint Core Technology Patent by a Third Party in a country, wherein the suspected infringing activity competes with a Product being commercialized by or on behalf of Sanofi in such country, the
Parties’ respective rights and obligations with respect to enforcement of such Joint Core Technology Patent in such country (including damages or settlement amounts received as a result thereof) shall be as set forth in Section 8.4.1,
mutatis mutandis. In the event of any other suspected infringement of a Joint Core Technology Patent, the Parties’ respective rights and obligations with respect to enforcement of such Joint Core Technology Patent in such country will be
the reverse of their respective rights and obligations under Section 8.4.1, mutatis mutandis; provided, however, that after reimbursement of costs, any remaining damages or other amounts recovered will be allocated [...***...]% to
the Party that brought and controlled the action, and [...***...]% to the other Party. 
 8.4.4 Other Joint
Patents. In the event of suspected infringement of an Other Joint Patent by a Third Party in a country, wherein the suspected infringing activity competes with a Product being commercialized by or on behalf of Sanofi in such country, the
Parties’ respective rights and obligations with respect to enforcement of such Other Joint Patent in such country shall be as set forth in Section 8.4.1, mutatis mutandis. In the event of any other suspected infringement of an Other
Joint Patent, the Parties shall mutually agree in good faith on a case-by-case basis on the course of action to be taken and the allocation of costs and recovered amounts. 
 8.4.5 Cooperation. The Party not enforcing a particular Patent under any of the preceding provisions of this Section 8.4 will provide reasonable assistance to the other Party (at such other
Party’s expense), including providing access to relevant documents and other evidence, making its employees available at reasonable business hours, and joining the action to the extent necessary to allow the enforcing Party to initiate or
maintain the action. 

  
 ***Confidential
Treatment Requested 
 39. 








 Section 8.5 Determination of Certain Patent Matters. The Parties, acting in good
faith and on the advice of their respective internal or external patent counsel, agree in good faith on: (i) the inventorship of Program Inventions under Section 8.1.1, consistent with U.S. patent laws; (ii) whether any particular
Regulus Patent is a Regulus Core Technology Patent or a Product Specific Patent, taking into full consideration the definitions of such terms set forth in APPENDIX 1 and the Regulus Patents listed in APPENDIX
2 and APPENDIX 3 hereto; and (iii) whether there exists a Product Specific Patent that is suspected to be infringed by a suspected infringement under Section 8.4.1. If the Parties cannot agree upon any such matter
within 30 days of good faith discussions, the Parties will refer such matter to independent patent counsel, not engaged by either Party or any of its Affiliates for any matter in the previous three (3) years and reasonably acceptable to both
Parties. The determination of the independent patent counsel with respect to such matter will be binding on the Parties. The costs and expenses of the independent patent counsel will be shared equally between the Parties. 

Section 8.6 Data Exclusivity and Orange Book Listings. With respect to data exclusivity periods (such as those periods listed
in the FDA’s Orange Book (including without limitation any available pediatric extensions) or periods under national implementations of Article 11.1(a)(iii) of Directive 2001/EC/83, or similar periods as may be applicable to a biologic, and all
international equivalents), Sanofi will use Commercially Reasonable Efforts consistent with its obligations under applicable law (including any applicable consent order) to seek, maintain and enforce all such data exclusivity periods available for
the Products exclusively licensed by Sanofi hereunder. With respect to filings in the FDA Orange Book or other similar filings or listings as may be applicable (and foreign equivalents) for issued patents for a Product, upon reasonable request by
Sanofi, Regulus will provide reasonable cooperation to Sanofi in filing and maintaining any such listing and filings. All listing and filing decisions will be at the sole discretion of Sanofi; provided, however that Sanofi will not list
Regulus Core Technology Patents in the FDA Orange Book without Regulus’ prior written consent, such consent not to be unreasonably withheld or delayed. In no event will Regulus withhold or delay such consent where the listing of such Regulus
Core Technology Patent is required under applicable law. 
 Section 8.7 Further Actions. Each Party will, upon the
reasonable request of the other Party, provide such assistance and execute such documents as are reasonably necessary for such Party to exercise its rights and/or perform its obligations pursuant to this Article 8; provided however, that
neither Party will be required to take any action pursuant to Article 8 that such Party reasonably determines in its sole judgment and discretion conflicts with or violates any applicable court or government order or decree. 

Section 8.8 Infringement Claims; Oppositions. Sanofi and Regulus will promptly inform the other in writing of any written
notice to it of alleged infringement or misappropriation, based on the research, development, making, using, importing, exporting or selling of a Licensed Compound or Product, of a Third Party’s intellectual property rights of which it will
become aware. The Parties will confer on the handling of such matter. Regulus will not acknowledge to a Third Party the validity of any such allegation or admit liability without the prior written consent of Sanofi, and Sanofi will not acknowledge
to a Third Party the validity of any such allegation or admit liability without the prior written consent of Regulus. Sanofi and Regulus will each keep the other advised of all material developments in the conduct


  
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of any proceedings in defending any claim of such alleged infringement or misappropriation and will cooperate with the other in the conduct of such defense. In no event may either Party settle
any such infringement or misappropriation claim in a manner that would limit the rights of the other Party or impose any obligation on the other Party, without such other Party’s prior written consent, such consent not to be unreasonably
withheld or delayed. Sanofi and Regulus will promptly inform the other in writing of any written notice to it of actual or threatened opposition related to the Product Specific Patents. The Parties will confer on the handling of such matter and such
matters will be handled in accordance with Section 8.2 above. 
 Section 8.9 Records Regarding Regulus Patents.
Each Party will assign patent counsel representatives who will be responsible for coordinating activities between the Parties in accordance with this Article 8. Such representatives will use commercially reasonable efforts to maintain a report
listing the Regulus Patents that are subject to the license granted to Sanofi under Section 2.1. Such report will be used to facilitate the identification and tracking of the Regulus Patents licensed under this Agreement, but will not, unless
specifically agreed to in a separate written agreement signed by authorized representatives of both Parties, be considered to be a then-current complete and binding list of the Regulus Patents licensed under this Agreement. 

Section 8.10 No Challenge. As a material inducement for entering into this Agreement, Sanofi covenants to Regulus that during
the term of this Agreement, solely with respect to claims within the Regulus Patents that are included in the license granted to Sanofi under Section 2.1, Sanofi, its Affiliates or sublicensees will not (a) commence or otherwise
voluntarily determine to participate in (other than as may be necessary or reasonably required to respond to a court request or order or administrative law request or order) any action or proceeding, challenging or denying the validity of any claim
within an issued patent or patent application within the Regulus Patents, or (b) direct, support or actively assist any other Person (other than as may be necessary or reasonably required to respond to a court request or order or administrative
law request or order) in bringing or prosecuting any action or proceeding challenging or denying the validity of any claim within an issued patent or patent application within the Regulus Patents. For purposes of clarification, any breach of this
Section 8.10 will be a material breach of this Agreement and will be grounds for termination by Regulus of this Agreement under Section 9.3. 
 Section 8.11 Amendments to Third Party Agreements. Regulus will not amend or agree to amend any Existing Regulus Agreement, Future Regulus Agreement, or New Core Technology Agreement for New
Core Technology included in the Regulus Technology licensed to Sanofi under Section 2.1, in any manner that would increase Sanofi’s payment obligations or reduce the scope of Sanofi’s license under Section 2.1, without the prior
written consent of Sanofi. 
 ARTICLE 9 
 TERM AND TERMINATION 

  
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 Section 9.1 Term. The term of this Agreement (the
“Term”) commences upon the Effective Date and, unless earlier terminated in accordance with the provisions of this Article 9, will continue until the expiration of all payment obligations on all Products to Regulus.

 Section 9.2 Sanofi Right to Terminate. 
 9.2.1 After the expiration of the Research Term, Sanofi may terminate this Agreement (including its license rights under this Agreement) in full, or on a Product-by-Product basis, effective upon 30
days prior written notice. For purposes of clarification, milestone and royalty payments will be due on milestones achieved and Products sold during the period between notice of termination and the effective date of termination. 

9.2.2 At any time during the Research Term, but following payment by Sanofi of the technology access fee under Section 6.1,
Sanofi will be entitled to terminate the license granted under Section 2.1 at any time on a Product-by-Product basis for any safety, efficacy or regulatory viability issues, including but not limited to the detection in a test population of
adverse experiences associated with the administration of the Product that are significant, serious or life threatening to the patient or demonstrate significant toxicological effect(s) of such Product on one or more body tissues that are not
balanced by a countervailing benefit to the patient. The safety, efficacy and regulatory viability of a Product will be determined by Sanofi in view of the risk to benefit relationship of such Product in the relevant patient population. 

Section 9.3 Material Breach. 
 (a) If either Party believes that the other is in material breach of this Agreement (other than with respect to a breach of Sanofi’s obligations under Section 5.1, which is governed by
Section 9.4), then the non-breaching Party may deliver notice of such breach to the other Party. In such notice the non-breaching Party will identify the actions or conduct that it wishes such Party to take for an acceptable and prompt cure of
such breach (or will otherwise state its good faith belief that such breach is incurable); provided that such identified actions or conduct will not be binding upon the other Party with respect to the actions that it may need to take to cure
such breach. If the breach is curable, the allegedly breaching Party will have 120 days to either cure such breach (except to the extent such breach involves the failure to make a payment when due, which breach must be cured within 30 days following
such notice) or, if a cure cannot be reasonably effected within such 120-day period, to deliver to the non-breaching Party a plan for curing such breach which is reasonably sufficient to effect a cure within a reasonable period. If the breaching
Party fails to (i) cure such breach within the 120-day (or 30- day, as applicable) period or (ii) use Commercially Reasonable Efforts to carry out the plan and cure the breach, the non-breaching Party may terminate this Agreement on a
Product-by-Product basis by providing written notice to the breaching Party. 
 (b) Notwithstanding the foregoing, if
the allegedly breaching Party disputes in good faith the existence, materiality, or failure to cure of any such breach which is not a payment breach, and provides notice to the non-breaching Party (the “Other Party”) of such
dispute within such 120-day period, the Other Party will not have the right to terminate this Agreement in accordance with this Section 9.3 unless and until it has been determined in accordance with Section 12.4 that this Agreement was
materially breached by the allegedly 

  
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breaching Party and that Party fails to cure such breach within 120 days following such determination. It is understood and acknowledged that during the pendency of such a dispute, all of the
terms and conditions of this Agreement will remain in effect and the Parties will continue to perform all of their respective obligations hereunder. 
 (c) This Section 9.3 will be subject to and will not limit the provisions of Section 9.4 and Section 9.5. 
 Section 9.4 Termination by Regulus For Failure of Sanofi to Use Commercially Reasonable Efforts. 
 9.4.1 Subject to Section 9.4.2 and 9.4.3, at any time after the expiration of the Research Term, Regulus will have the right to terminate the license granted under Section 2.1 (and the
corresponding exclusivity obligation under Section 2.3) on a Product-by-Product basis and country-by-country basis, if Sanofi is in breach of its obligations to use Commercially Reasonable Efforts as set forth in Section 5.1, provided
however, that the Agreement will not so terminate unless (i) Sanofi is given 30 days prior written notice by Regulus of Regulus’ intent to terminate, stating the reasons and justification for such termination and recommending steps
which Sanofi should take, and (ii) Sanofi, or its sublicensee, has not used good faith Commercially Reasonable Efforts during the 120-day period following such notice to diligently pursue the Development and/or Commercialization of at least one
Licensed Compound or Product for each Collaboration Target in the applicable country. Any such termination will be limited in force and effect to the country or countries and Products to which such breach relates. 

9.4.2 It is understood and acknowledged that if Sanofi (by itself or through its Affiliates or sublicensees) uses Commercially
Reasonable Efforts to Develop and Commercialize a Product for each Collaboration Target in each and every Major Market Country, Sanofi will be deemed to be in compliance with its obligation under Section 5.1 to use Commercially Reasonable
Efforts to Develop and Commercialize a Product for such Collaboration Target with respect to all countries in the world. 

9.4.3 If Sanofi disputes in good faith the existence or materiality of an alleged breach specified in a notice provided by Regulus
pursuant to Section 9.4.1, and provides notice to Regulus of such dispute within the 30 days following such notice provided by Regulus, Regulus will not have the right to terminate this Agreement unless and until the existence of such material
breach or failure by Sanofi has been determined in accordance with Section 12.4 and Sanofi fails to cure such breach within 30 days following such determination. It is understood and acknowledged that during the pendency of such a dispute, all
of the terms and conditions of this Agreement will remain in effect and the Parties will continue to perform all of their respective obligations hereunder. 
 Section 9.5 Consequences of Termination. 
 9.5.1 Licenses. Upon
termination of this Agreement in its entirety by either Party pursuant to this Article 9, the licenses granted by Regulus to Sanofi hereunder will terminate. 

  
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 9.5.2 Return of Information and Materials. Upon termination of this Agreement in its
entirety by either Party pursuant to this Article 9, the Parties will return (or destroy, as directed by the other Party) all data, files, records and other materials containing or comprising the other Party’s Confidential Information.
Notwithstanding the foregoing, the Parties will be permitted to retain one copy of such data, files, records, and other materials for archival purposes, and with respect to Regulus, to practice its rights under Section 10.1. 

Section 9.6 Accrued Rights; Surviving Obligations. 
 9.6.1 Accrued Rights. Termination or expiration of this Agreement for any reason will be without prejudice to any rights or financial compensation that will have accrued to the benefit of a Party
prior to such termination or expiration. Such termination or expiration will not relieve a Party from obligations that are expressly indicated to survive the termination or expiration of this Agreement. 

9.6.2 Survival. Articles 7, 9, 10, 11 and 13; and Section 3.6.4, Section 6.14, Section 6.17, and Section 12.4
of this Agreement will survive expiration or termination of this Agreement for any reason. Furthermore, Regulus hereby grants to Sanofi a worldwide non-exclusive license, with the right to grant sublicenses under Section 2.2, to Regulus
Know-How existing now or in the future and disclosed to Sanofi during the Term, solely for the further manufacture and sale of Licensed Compounds and Products after the expiration (but not the termination) of the Term. 

Section 9.7 Rights in Bankruptcy. All rights and licenses granted under or pursuant to this Agreement by Regulus or Sanofi
are, and will otherwise be deemed to be, for purposes of Section 365(n) of the U.S. Bankruptcy Code (i.e., Title 11 of the U.S. Code) or analogous provisions of Applicable Law outside the United States, licenses of rights to “intellectual
property” as defined under Section 101 of the U.S. Bankruptcy Code or analogous provisions of Applicable Law outside the United States. The Parties agree that each Party, as licensee of such rights under this Agreement, will retain and may
fully exercise all of its rights and elections under the U.S. Bankruptcy Code or any other provisions of Applicable Law outside the United States that provide similar protection for ‘intellectual property.’ The Parties further agree that,
in the event of the commencement of a bankruptcy proceeding by or against a Party under the U.S. Bankruptcy Code or analogous provisions of Applicable Law outside the United States, the Party that is not subject to such proceeding will be entitled
to a complete duplicate of (or complete access to, as appropriate) such intellectual property and all embodiments of such intellectual property, which, if not already in the non subject Party’s possession, will be promptly delivered to it upon
the non subject Party’s written request therefor. Any agreements supplemental hereto will be deemed to be “agreements supplementary to” this Agreement for purposes of Section 365(n) of the U.S. Bankruptcy Code. 

ARTICLE 10 

REGULUS REVERSION RIGHT 
 Section 10.1 Regulus Reversion Rights. If (i) Sanofi terminates the Agreement (in full or on a Product-by-Product basis) under Section 9.2, (ii) Sanofi makes a substitution
under 

  
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Section 3.6.2, or (iii) Regulus terminates the Agreement under Section 9.3 or 9.4, Regulus may continue to Develop and Commercialize any Licensed Compound or Product that is the
subject of such termination or substitution (a “Discontinued Product”). If Regulus provides a notice in writing to Sanofi within 90 days of such termination (an “Election Notice”) that Regulus is
exercising its rights under this Section 10.1, subject to Regulus’ payment obligations in Section 10.2, Sanofi will, and it hereby does: (x) grant to Regulus a sublicensable, [...***...] license or sublicense, as the case
may be, to all [...***...] [...***...] and [...***...] by Sanofi as of the date of the Election Notice solely as they are necessary to make, have made, use, sell, offer for sale, have sold and import Discontinued Products,
(y) transfer to Regulus, for Regulus’ use with respect to the Development and Commercialization of the Discontinued Products, [...***...] [...***...] as of the date of the Election Notice that relate to such Discontinued
Products, and (z) [...***...] to Regulus all [...***...] with respect to such Discontinued Product (including but not limited to [...***...] for Regulus, and [...***...] Regulus to [...***...], any
[...***...] with a [...***...] related to such Discontinued Product). 
 Section 10.2 Regulus Payment
Obligations for Reversion Rights. If Regulus provides an Election Notice for any Discontinued Product which has completed a [...***...] prior to the applicable termination under this Agreement, then Regulus shall pay to Sanofi
(i) [...***...]% of any [...***...] such Discontinued Product [...***...]; or (ii) if [...***...]% of the [...***...] such Discontinued Product [...***...] with the provisions of Section 6.6 through
Section 6.17 applying mutatis mutandis. For purposes of this Agreement, “Licensing Revenues” will mean any payments that Regulus receives from a Third Party in consideration of a license to further the Development
and Commercialization of a Discontinued Product, in each case including, but not limited to, upfront payments, license fees, regulatory or sales milestone payments, royalties and/or profit sharing payments, but excluding: (i) payments
made in consideration of [...***...], (ii) payments to [...***...], and (iii) payments to [...***...]. 
 ARTICLE 11 
 INDEMNIFICATION, INSURANCE AND LIMITATION OF LIABILITY

 Section 11.1 Indemnification of Regulus. Sanofi agrees to defend Regulus, its Affiliates and their respective
directors, officers, stockholders, employees and agents, and their respective successors, heirs and assigns (collectively, the “Regulus Indemnitees”), and will indemnify and hold harmless the Regulus Indemnitees, from and
against any liabilities, losses, costs, damages, fees or expenses payable to a Third Party, and reasonable attorneys’ fees and other legal expenses with respect thereto (collectively, “Losses”) arising out of any claim,
action, lawsuit or other proceeding by a Third Party (collectively, “Third Party Claims”) brought against any Regulus Indemnitee and resulting from or occurring as a result of: (a) the


  
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Development, manufacture, use, handling, storage, sale or other Commercialization or disposition of any Licensed Compound or Product in the Territory by Sanofi or its Affiliates, sublicensees or
contractors, (b) any breach by Sanofi of any of its representations, warranties or covenants pursuant to this Agreement or (c) the negligence or willful misconduct of Sanofi or any Sanofi Affiliate or sublicensee in connection with this
Agreement; except in any such case to the extent such Losses result from: (i) the negligence or willful misconduct of any Regulus Indemnitee, (ii) any breach by Regulus of any of its representations, warranties, covenants or
obligations pursuant to this Agreement, or (iii) any breach of Applicable Law by any Regulus Indemnitee. 

Section 11.2 Indemnification of Sanofi. Regulus agrees to defend Sanofi, its Affiliates and their respective directors,
officers, stockholders, employees and agents, and their respective successors, heirs and assigns (collectively, the “Sanofi Indemnitees”), and will indemnify and hold harmless the Sanofi Indemnitees, from and against any
Losses and Third Party Claims brought against any Sanofi Indemnitee and resulting from or occurring as a result of: (a) any activities conducted by a Regulus employee, consultant or (sub)contractor in the performance of the Research Program
(unless such activities were the subject of a dispute between Regulus’ and Sanofi’s representatives on the JSC that was finally resolved by Sanofi’s Senior Representative, as reflected in the minutes of JSC proceedings); (b) any
breach by Regulus of any of its representations, warranties or covenants pursuant to this Agreement or (c) the negligence or willful misconduct of any Regulus Indemnitee or any (sub)contractor of Sanofi in connection with this Agreement;
except in any such case to the extent such Losses result from: (i) the negligence or willful misconduct of any Sanofi Indemnitee, (ii) any breach by Sanofi of any of its representations, warranties, covenants or obligations pursuant
to this Agreement, or (iii) any breach of Applicable Law by any Sanofi Indemnitee. 
 Section 11.3 Notice of Claim.
All indemnification claims provided for in Sections 11.1 and 11.2 will be made solely by such Party to this Agreement (the “Indemnified Party”). The Indemnified Party will give the indemnifying Party prompt written
notice (an “Indemnification Claim Notice”) of any Losses or the discovery of any fact upon which the Indemnified Party intends to base a request for indemnification under Section 11.1 or 11.2, but in no event will the
indemnifying Party be liable for any Losses to the extent such Losses result from any delay in providing such notice. Each Indemnification Claim Notice must contain a description of the claim and the nature and amount of such Loss (to the extent
that the nature and amount of such Loss is known at such time). The Indemnified Party will furnish promptly to the indemnifying Party copies of all papers and official documents received in respect of any Losses and Third Party Claims. 

Section 11.4 Defense, Settlement, Cooperation and Expenses. 

11.4.1 Control of Defense. At its option, the indemnifying Party may assume the defense of any Third Party Claim by giving written
notice to the Indemnified Party within 30 calendar days after the indemnifying Party’s receipt of an Indemnification Claim Notice. The assumption of the defense of a Third Party Claim by the indemnifying Party will not be construed as an
acknowledgment that the indemnifying Party is liable to indemnify the Indemnified Party in respect of the Third Party Claim, nor will it constitute a waiver by the indemnifying Party of any defenses it may assert against the Indemnified Party’s
claim for 

  
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indemnification. Upon assuming the defense of a Third Party Claim, the indemnifying Party may appoint as lead counsel in the defense of the Third Party Claim any legal counsel selected by the
indemnifying Party. In the event the indemnifying Party assumes the defense of a Third Party Claim, the Indemnified Party will as soon as is reasonably possible deliver to the indemnifying Party all original notices and documents (including court
papers) received by the Indemnified Party in connection with the Third Party Claim. Should the indemnifying Party assume the defense of a Third Party Claim, except as provided in Section 11.4.1, the Indemnified Party will be responsible for the
legal costs or expenses subsequently incurred by such Indemnified Party in connection with the analysis, defense or settlement of the Third Party Claim. 
 11.4.2 Right to Participate in Defense. Without limiting Section 11.4.1, any Indemnified Party will be entitled to participate in, but not control, the defense of such Third Party Claim and to
employ counsel of its choice for such purpose; provided, however, that such employment will be at the Indemnified Party’s own cost and expense unless (i) the employment thereof has been specifically authorized by the indemnifying
Party in writing, (ii) the indemnifying Party has failed to assume the defense and employ counsel in accordance with Section 11.4.1 (in which case the Indemnified Party will control the defense) or (iii) the interests of the
Indemnified Party and the indemnifying Party with respect to such Third Party Claim are sufficiently adverse to prohibit the representation by the same counsel of both Parties under Applicable Law, ethical rules or equitable principles in which case
the indemnifying Party will be responsible for any such costs and expenses of counsel for the Indemnified Party. 
 11.4.3
Settlement. With respect to any Third Party Claims relating solely to the payment of money damages in connection with a Third Party Claim and that will not admit liability or violation of Law on the part of the Indemnified Party or result in the
Indemnified Party’s becoming subject to injunctive or other relief or otherwise adversely affecting the business of the Indemnified Party in any manner (such as granting a license or admitting the invalidity of a Patent Controlled by an
Indemnified Party), and as to which the indemnifying Party will have acknowledged in writing the obligation to indemnify the Indemnified Party hereunder, the indemnifying Party will have the sole right to consent to the entry of any judgment, enter
into any settlement or otherwise dispose of such Loss, on such terms as the indemnifying Party, in its sole discretion, will deem appropriate. With respect to all other Losses in connection with Third Party Claims, where the indemnifying Party has
assumed the defense of the Third Party Claim in accordance with Section 11.4.1, the indemnifying Party will have authority to consent to the entry of any judgment, enter into any settlement or otherwise dispose of such Loss provided it obtains
the prior written consent of the Indemnified Party (which consent will not be unreasonably withheld). The indemnifying Party will not be liable for any settlement or other disposition of a Loss by an Indemnified Party that is reached without the
written consent of the indemnifying Party. Regardless of whether the indemnifying Party chooses to defend or prosecute any Third Party Claim, no Indemnified Party will admit any liability with respect to or settle, compromise or discharge, any Third
Party Claim without the prior written consent of the indemnifying Party, such consent not to be unreasonably withheld. 

11.4.4 Cooperation. Regardless of whether the indemnifying Party chooses to defend or prosecute any Third Party Claim, the
Indemnified Party will, and will cause each other Indemnified Party to, cooperate in the defense or prosecution thereof and will furnish such 

  
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records, information and testimony, provide such witnesses and attend such conferences, discovery proceedings, hearings, trials and appeals as may be reasonably requested in connection therewith.
Such cooperation will include access during normal business hours afforded to indemnifying Party to, and reasonable retention by the Indemnified Party of, records and information that are reasonably relevant to such Third Party Claim, and making
Indemnified Parties and other employees and agents available on a mutually convenient basis to provide additional information and explanation of any material provided hereunder, and the indemnifying Party will reimburse the Indemnified Party for all
its reasonable out-of-pocket costs and expenses in connection therewith. 
 11.4.5 Costs and Expenses. Except as provided
above in this Section 11.4, the costs and expenses, including attorneys’ fees and expenses, incurred by the Indemnified Party in connection with any claim will be reimbursed on a Calendar Quarter basis by the indemnifying Party, without
prejudice to the indemnifying Party’s right to contest the Indemnified Party’s right to indemnification and subject to refund in the event the indemnifying Party is ultimately held not to be obligated to indemnify the Indemnified Party.

 Section 11.5 Insurance. 
 11.5.1 Regulus’ Insurance Obligations. Regulus shall maintain, at its cost, reasonable insurance against liability and other risks associated with its activities contemplated by this
Agreement, including but not limited to its indemnification obligations herein, in such amounts and on such terms as are customary for prudent practices for biotech companies of similar size and with similar resources in the pharmaceutical industry
for the activities to be conducted by it under this Agreement taking into account the scope of development of products, provided, that, at a minimum, Regulus shall maintain, in force at its sole cost, a general liability insurance policy providing
coverage of at least $[...***...] per claim and $[...***...] annual aggregate. In addition to the foregoing, in the event that Regulus plans to Commercialize any Discontinued Product, then Regulus shall increase its insurance coverage
commensurate with the additional liability and other risks associated with Commercialization activities, and at a minimum provide that the annual aggregate amount of such coverage is increased to at least $[...***...] at least thirty
(30) days before Regulus initiates the First Commercial Sale of any Discontinued Product hereunder. Regulus shall furnish to Sanofi evidence of any insurance required under this Section 11.5, upon request. 

11.5.2 Sanofi’s Insurance Obligations. Sanofi hereby represents and warrants to Regulus that it is self-insured against
liability and other risks associated with its activities and obligations under this Agreement in such amounts and on such terms as are customary for prudent practices for large companies in the pharmaceutical industry for the activities to be
conducted by Sanofi under this Agreement. Sanofi shall maintain such self insurance throughout the term of this Agreement and shall furnish to Regulus evidence of such self-insurance, upon request. 

ARTICLE 12 

REPRESENTATIONS AND WARRANTIES 

  
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 Section 12.1 Representations, Warranties and Covenants. Each Party hereby
represents and warrants as of both the Effective Date and covenants to the other Party that: 
 12.1.1 it has the power
and authority and the legal right to enter into this Agreement and perform its obligations hereunder, and that it has taken all necessary action on its part required to authorize the execution and delivery of this Agreement and the performance of
its obligations hereunder; 
 12.1.2 this Agreement has been duly executed and delivered on behalf of such Party and
constitutes a legal, valid and binding obligation of such Party and is enforceable against it in accordance with its terms subject to the effects of bankruptcy, insolvency or other laws of general application affecting the enforcement of creditor
rights and judicial principles affecting the availability of specific performance and general principles of equity, whether enforceability is considered a proceeding at law or equity; 

12.1.3 all necessary consents, approvals and authorizations of all Regulatory Authorities and other parties required to be
obtained by such Party in connection with the execution and delivery of this Agreement and the performance of its obligations hereunder have been obtained; and 
 12.1.4 the execution and delivery of this Agreement and the performance of such Party’s obligations hereunder (i) do not conflict with or violate any requirement of Applicable Law or any
provision of the certificate of incorporation, bylaws or any similar instrument of such Party, as applicable, in any material way, and (ii) do not conflict with, violate, or breach or constitute a default or require any consent not already
obtained under, any contractual obligation or court or administrative order by which such Party is bound. 

Section 12.2 Regulus Representations, Warranties, and Covenants. Regulus hereby represents and warrants to Sanofi as of the
Effective Date that: 
 12.2.1 Regulus is the owner of, or otherwise has the right to grant all rights and licenses it
purports to grant to Sanofi with respect to the Regulus Patents under this Agreement for Mir-21 and Licensed Compounds identified by Regulus on or before the Effective Date that target Mir-21; 

12.2.2 To the best of its knowledge and belief, Regulus does not require any additional licenses or other intellectual property
rights in order for Regulus to conduct its obligation under the R&D Plan with respect to Mir-21 and Licensed Compounds identified by Regulus on or before the Effective Date that target Mir-21; 

12.2.3 Regulus has not received any written claim alleging that any of the Regulus Patents are invalid or unenforceable;

 12.2.4 Regulus has not received any written claim alleging that any of Regulus’ activities relating to Mir-21 and
Licensed Compounds identified by Regulus on or before the Effective Date that target Mir-21, or any of Regulus’ activities of the type proposed to be undertaken pursuant to the R&D Plan, infringe any intellectual property rights of a Third
Party; 

  
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 12.2.5 All employees, consultants, or (sub)contractors of Regulus or Affiliates
performing Development activities hereunder on behalf of Regulus are, and Regulus hereby covenants to Sanofi that they will be, obligated to assign all right, title and interest in and to any inventions developed by them, whether or not patentable,
to Regulus or Affiliate, respectively, as the sole owner thereof; 
 12.2.6 Regulus will, and Regulus hereby covenants
to, as appropriate, hire and maintain sufficient staff and management to support and conduct all the Research Program hereunder in a timely fashion; 
 12.2.7 If reasonably requested by Sanofi in writing, Regulus will, and Regulus hereby covenants to, take reasonable, good faith measures and cooperate with Sanofi to help to facilitate a good faith
negotiation between Sanofi and any Existing Regulus Agreement in the event that Sanofi desires to pursue the Development or Commercialization of any Licensed Compound or Product and would require a license directly from any such Third Party;

 12.2.8 Regulus will not, and Regulus hereby covenants to Sanofi not to, withhold from Sanofi any material information
or correspondence, including to or from any Regulatory Authority, that would be material and relevant to a reasonable assessment of the scientific, commercial, safety, and regulatory liabilities or commercial value of the Licensed Compounds;

 12.2.9 Regulus will, and Regulus hereby covenants to Sanofi that it will, perform its activities pursuant to this
Agreement in compliance with good laboratory and clinical practices and cGMP, in each case as applicable under the laws and regulations of the country and the state and local government wherein such activities are conducted, and with respect to the
care, handling and use in Development activities hereunder of any non-human animals by or on behalf of Regulus, will at all times comply (and will ensure compliance by any of its subcontractors) with all applicable federal, state and local laws,
regulations and ordinances and the guiding principles of the “3R’s”, namely, wherever reasonably possible, reducing the number of animals used, replacing animals with non-animal methods and refining the research techniques used for
the proper care, handling and use of animals in pharmaceutical research and development activities; and 
 12.2.10 The
licenses granted to Regulus under the Existing Regulus Agreements are in full force and effect and Regulus has not received any written notice, and is not aware, of any breach by any party to the Existing Regulus Agreements. 

Section 12.3 Sanofi Covenants. Sanofi hereby covenants to Regulus that it will perform its activities pursuant to this
Agreement in compliance with good laboratory and clinical practices and cGMP, in each case as applicable under the laws and regulations of the country and the state and local government wherein such activities are conducted, and with respect to the
care, handling and use in Development activities hereunder of any non-human animals by or on behalf of Sanofi, will at all times comply (and will ensure compliance by any of its subcontractors) with all Applicable Laws and the guiding principles of
the “3R’s”, namely, wherever reasonably possible, reducing the number of animals used, replacing animals with non-animal methods and refining the research techniques used for the proper care, handling and use of animals in
pharmaceutical research and development activities. 

  
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 Section 12.4 DISCLAIMER OF WARRANTY. EXCEPT FOR THE EXPRESS WARRANTIES SET FORTH
IN THIS ARTICLE 12, SANOFI AND REGULUS MAKE NO REPRESENTATIONS AND GRANT NO WARRANTIES, EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, BY STATUTE OR OTHERWISE, AND SANOFI AND REGULUS EACH SPECIFICALLY DISCLAIM ANY WARRANTIES, WHETHER
WRITTEN OR ORAL, OR EXPRESS OR IMPLIED, INCLUDING ANY WARRANTY OF QUALITY, MERCHANTABILITY OR FITNESS FOR A PARTICULAR USE OR PURPOSE OR ANY WARRANTY AS TO THE VALIDITY OF ANY PATENTS OR THE NON-INFRINGEMENT OF ANY INTELLECTUAL PROPERTY RIGHTS OF
THIRD PARTIES. 
 ARTICLE 13 
 MISCELLANEOUS 
 Section 13.1 Assignment; Sanofi Affiliates.
Except as expressly set forth in this Agreement, without the prior written consent of the other Party hereto, neither Party will sell, transfer, assign, delegate, pledge or otherwise dispose of, whether voluntarily, involuntarily, by operation
of law or otherwise, this Agreement or any of its rights or duties hereunder; provided, however, that: 
 (a)
either Party may assign this Agreement and its rights and obligations hereunder without the other Party’s consent in connection with the transfer or sale of all or substantially all of the business of such Party to which this Agreement
relates to a Third Party, whether by merger, sale of stock, sale of assets or otherwise, provided that in the event of such a sale or transfer (whether this Agreement is actually assigned or is assumed by the acquiring party by operation of law
(e.g., in the context of a reverse triangular merger)), intellectual property rights of the acquiring party in such sale or transfer (if other than one of the Parties to this Agreement) shall not be included in the technology licensed hereunder or
otherwise subject to this Agreement; 
 (b) Sanofi may, without Regulus’ consent, assign this Agreement and its
rights and obligations hereunder to an Affiliate of Sanofi, provided that such Affiliate agrees to be bound by the terms and conditions of this Agreement and that no such assignment to an Affiliate will relieve Sanofi of its obligations hereunder;
and 
 (c) Regulus may assign or transfer its rights under Article 6 (but no liabilities) to a Third Party in connection
with a royalty factoring transaction. 
 The rights and obligations of the Parties under this Agreement shall be binding upon
and inure to the benefit of the successors and permitted assigns of the Parties, and the name of a Party appearing herein will be deemed to include the name of such Party’s successors and permitted assigns to the extent necessary to carry out
the intent of this section. Any purported assignment or transfer in violation of this Section 13.1 will be void ab initio and of no force or effect. 
 Section 13.2 Severability. If any provision of this Agreement is held to be illegal, invalid or unenforceable by a court of competent jurisdiction, such adjudication will not affect or


  
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impair, in whole or in part, the validity, enforceability, or legality of any remaining portions of this Agreement. All remaining portions will remain in full force and effect as if the original
Agreement had been executed without the invalidated, unenforceable or illegal part. 
 Section 13.3 Governing Law;
Jurisdiction. This Agreement will be governed by and construed and enforced in accordance with the laws of the State of New York, USA without reference to any rules of conflicts of laws. For clarification, any dispute relating to the scope,
validity, enforceability or infringement of any Patents will be governed by and construed and enforced in accordance with the patent laws of the applicable jurisdiction. 
 Section 13.4 Dispute Resolution. 
 13.4.1 Resolution by Senior
Representatives. The Parties will seek to settle amicably any and all disputes, controversies or claims arising out of or in connection with this Agreement. Any dispute within the JSC’s decision-making authority will be finally decided as
set forth in APPENDIX 5. Any dispute between the Parties which is outside the JSC’s decision-making authority and is not subject to resolution under Section 6.7.1 or Section 13.4.5 will be promptly presented to
each Party’s respective co-chair of the JSC for resolution, and if the co-chairs of the JSC are unable to resolve such dispute, such dispute will then be presented to the Executive VP of R&D of Sanofi and the Executive Vice President of
Regulus (the “Senior Representatives”), or their respective designees, for resolution. Such Senior Representatives, or their respective designees, will meet in-person or by teleconference as soon as reasonably possible
thereafter, and use their good faith efforts to mutually agree upon the resolution of the dispute, controversy or claim. Any dispute within the JSC’s decision-making authority will not be subject to arbitration. 

13.4.2 Request for Arbitration. If after negotiating in good faith pursuant to Section 13.4.1, after good faith discussions
undertaken within reasonable promptness, to reach an amicable agreement within 90 days, then either Party may upon written notice to the other submit to binding arbitration pursuant to Section 13.4.3 below. No statements made by either Party
during such discussions will be used by the other Party or admissible in arbitration or any other subsequent proceeding for resolving the dispute. 
 13.4.3 Arbitration. 
 (a) Any dispute, claim or controversy arising
from or related in any way to this Agreement or the interpretation, application, breach, termination or validity thereof, including any claim of inducement of this Agreement by fraud or otherwise, not resolved under the provisions of
Section 13.4.1 will be resolved by final and binding arbitration conducted in accordance with the terms of this Section 13.4.3. The arbitration will be held in New York, New York, USA according to Rules of Arbitration of the International
Chamber of Commerce (“ICC”). The arbitration will be conducted by a panel of three (3) arbitrators with significant experience in the pharmaceutical industry, unless otherwise agreed by the Parties, appointed in
accordance with applicable ICC rules. Any arbitration herewith will be conducted in the English language to the maximum extent possible. The arbitrators will render a written decision no later than six (6) months following the selection of the
arbitrators, including a basis for any damages awarded and a statement of how the damages were calculated. Any award will be promptly paid 

  
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in U.S. dollars free of any tax, deduction or offset. Each Party agrees to abide by the award rendered in any arbitration conducted pursuant to this Section 13.4.3. With respect to money
damages, nothing contained herein will be construed to permit the arbitrator or any court or any other forum to award punitive or exemplary damages, except in the case of breach of Article 7. By entering into this agreement to arbitrate, the Parties
expressly waive any claim for punitive or exemplary damages, except in the case of breach of Article 7. Each Party will pay its legal fees and costs related to the arbitration (including witness and expert fees). Judgment on the award so rendered
will be final and may be entered in any court having jurisdiction thereof. 
 (b) EACH PARTY HERETO WAIVES ITS RIGHT TO
TRIAL OF ANY ISSUE BY JURY. EACH PARTY HERETO WAIVES ANY CLAIM FOR ATTORNEYS’ FEES AND COSTS AND PREJUDGMENT INTEREST FROM THE OTHER. 
 (c) EXCEPT FOR LOSSES COVERED BY THE INDEMNITIES PROVIDED UNDER ARTICLE 11, AND ANY BREACH OF THE CONFIDENTIALITY RESTRICTIONS UNDER ARTICLE 7, EACH PARTY HERETO WAIVES (1) ANY CLAIM TO
PUNITIVE, EXEMPLARY OR MULTIPLIED DAMAGES FROM THE OTHER; AND (2) ANY CLAIM OF CONSEQUENTIAL, INDIRECT OR INCIDENTAL DAMAGES FROM THE OTHER. 
 13.4.4 Disputes Regarding Material Breach. If the Parties are in dispute as to whether one Party is in material breach of this Agreement, then the arbitrator will first determine if material breach
has in fact occurred, and if so, will grant the defaulting Party the cure period provided pursuant to Section 9.3 (or 9.2, as applicable). If the material breach is not cured within the time period provided pursuant to Section 9.3 (or 9.2,
as applicable), the arbitration will continue and the arbitrator will, as part of the same arbitration, award actual direct damages to the non-defaulting Party. 
 13.4.5 Certain Matters Subject to Expert Panel. If, at any time during the Research Term, the parties disagree on any matter arising from the Research Program, the Parties may elect by mutual
agreement to submit such matter to a panel of three (3) experts who are experienced in the field of biopharmaceuticals (an “Expert Panel”). All members of the Expert Panel must be mutually agreed by the Parties in good
faith and as promptly as possible and must be free of any conflicts of interest with respect to either or both Parties. The Expert Panel will promptly hold a hearing to review the matter, at which they will consider briefs submitted by each Party at
least 15 days before the hearing, as well as reasonable presentations that each Party may present. The determination of the relevant Expert Panel as to such dispute will be binding on both Parties. The Parties will share equally in the costs of the
Expert Panel, and each Party will bear its own costs associated with preparing for and presenting to the Expert Panel. 

13.4.6 Court Actions. Nothing contained in this Agreement shall deny either Party the right to seek injunctive or other equitable
relief from a court of competent jurisdiction in the context of a bona fide emergency or prospective irreparable harm, and such an action may be filed and maintained notwithstanding any ongoing dispute resolution discussions or arbitration
proceeding. In addition, either Party may bring an action in any court of competent jurisdiction to resolve disputes pertaining to the validity, construction, scope, enforceability, 

  
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infringement or other violations of patents or other proprietary or intellectual property rights, and no such claim shall be subject to arbitration pursuant to Section 13.4.3. 

Section 13.5 Notices. Except as otherwise provided for in this Agreement, all notices or other communications that are
required or permitted hereunder will be in the English Language and in writing and delivered personally with acknowledgement of receipt, sent by facsimile (and promptly confirmed by personal delivery, registered or certified mail or overnight
courier as provided herein), sent by nationally-recognized overnight courier or sent by registered or certified mail, postage prepaid, return receipt requested, addressed as follows: 
 If to Sanofi, to: 
 Sanofi 

54, rue la Boétie 
 75008 Paris, France 
 Attention: General Counsel 

Facsimile No.: +33 1 53 77 43 03 

With a copy to: 
 Sanofi

 9 Rue du Président Allende, 94256 Gentilly Cedex, France 

Attention: License Management 
 Facsimile No.: +33 1 53 77 48 51 
 If to Regulus, to: 

Regulus Therapeutics Inc. 
 3545 John Hopkins Court, Suite 210 
 San Diego, California 92121-1121 

USA 
 Attention:
Executive Vice President 
 Facsimile: +1 (858) 202-6363 
 With a copy to: 
 Attention: General Counsel 

Facsimile: +1 (858) 202-6363 
 or to such other address as the Party to whom notice is to be given may have furnished to the other Party in writing in accordance herewith. Any such communication will be deemed to have been given
(i) when delivered, if personally delivered or sent by facsimile on a Business Day, (ii) on the Business Day after dispatch, if sent by nationally-recognized overnight courier, and (iii) on the third Business Day following the date of
mailing, if sent by mail. It is understood and agreed that this Section 13.5 is not intended to govern the day-to-day business communications necessary between the Parties in performing their duties, in due course, under the terms of this
Agreement. 

  
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 Section 13.6 Entire Agreement; Modifications. This Agreement (including the
attached Appendices and the R&D Plan), together with the Technology Alliance Agreement and the Stock Purchase Agreement, sets forth and constitutes the entire agreement and understanding between the Parties with respect to the subject matter
hereof and thereof, and all prior agreements, understanding, promises and representations, whether written or oral, with respect thereto are superseded hereby. Each Party confirms that it is not relying on any representations or warranties of the
other Party except as specifically set forth herein. No amendment, modification, release or discharge will be binding upon the Parties unless in writing and duly executed by authorized representatives of both Parties. 

Section 13.7 Headings. The headings of Articles and Sections of this Agreement are for ease of reference only and will not
affect the meaning or interpretation of this Agreement in any way. 
 Section 13.8 Relationship of the Parties. It
is expressly agreed that the Parties will be independent contractors of one another and that the relationship between the Parties will not constitute a partnership, joint venture or agency. 

Section 13.9 Waiver. Any term or condition of this Agreement may be waived at any time by the Party that is entitled to the
benefit thereof, but no such waiver will be effective unless set forth in a written instrument duly executed by or on behalf of the Party waiving such term or condition. Any such waiver will not be deemed a waiver of any other right or breach
hereunder. 
 Section 13.10 Counterparts. This Agreement may be executed in two or more counterparts, each of which
will be deemed an original, but all of which together will constitute one and the same instrument. 
 Section 13.11 No
Benefit to Third Parties. The representations, warranties, covenants and agreements set forth in this Agreement are for the sole benefit of the Parties hereto and their successors and permitted assigns, and they will not be construed as
conferring any rights on any other parties. 
 Section 13.12 Further Assurances. Each Party will duly execute and
deliver, or cause to be duly executed and delivered, such further instruments and do and cause to be done such further acts and things, including the filing of such assignments, agreements, documents and instruments, as may be necessary to carry out
the provisions and purposes of this Agreement. 
 Section 13.13 Force Majeure. Neither Party will be charged with
any liability for delay in performance of an obligation under this Agreement to the extent such delay is due to a cause beyond the reasonable control of the affected Party, such as war, riots, labor disturbances, fire, explosion, earthquake, and
compliance in good faith with any governmental Law, regulation or order. The Party affected will give prompt written notice to the other Party of any material delay due to such causes. 

Section 13.14 Interpretation. 
 13.14.1 Each of the Parties acknowledges and agrees that this Agreement has been diligently reviewed by and negotiated by and between them, that in such negotiations each of


  
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them has been represented by competent counsel and that the final agreement contained herein, including the language whereby it has been expressed, represents the joint efforts of the Parties
hereto and their counsel. Accordingly, in the event an ambiguity or a question of intent or interpretation arises, this Agreement will be construed as if drafted jointly by the Parties and no presumption or burden of proof will arise favoring or
disfavoring any Party by virtue of the authorship of any provisions of this Agreement. This Agreement has been prepared in the English language and the English language shall control its interpretation. 

13.14.2 The definitions of the terms herein will apply equally to the singular and plural forms of the terms defined. Whenever the
context may require, any pronoun will include the corresponding masculine, feminine and neuter forms. The words “include”, “includes” and “including” will be deemed to be followed by the phrase “without
limitation”. The word “will” will be construed to have the same meaning and effect as the word “will”. The word “any” will mean “any and all” unless otherwise clearly indicated by context. 

13.14.3 Unless the context requires otherwise, (i) any definition of or reference to any agreement, instrument or other
document herein will be construed as referring to such agreement, instrument or other document as from time to time amended, supplemented or otherwise modified (subject to any restrictions on such amendments, supplements or modifications set forth
herein or therein), (ii) any reference to any Applicable Laws herein will be construed as referring to such Applicable Laws as from time to time enacted, repealed or amended, (iii) any reference herein to any person will be construed to
include the person’s successors and assigns, (iv) the words “herein”, “hereof” and “hereunder”, and words of similar import, will be construed to refer to this Agreement in its entirety and not to any
particular provision hereof, and (v) all references herein to Articles, Sections or Appendices, unless otherwise specifically provided, will be construed to refer to Articles, Sections and Appendices of this Agreement. 

13.14.4 References to sections of the Code of Federal Regulations and to the United States Code will mean the cited sections, as
these may be amended from time to time. 
 [SIGNATURE PAGE FOLLOWS]


  
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 IN WITNESS WHEREOF, the Parties hereto have caused this Agreement to be executed by
their duly authorized representatives as of the date first above written. 
  

			
	REGULUS THERAPEUTICS INC.
		
	By:	 	 /s/ Garry E. Menzel



			
		
	Name:	 	 Garry E. Menzel



			
		
	Title:	 	 Chief Operating Officer



			
	
	SANOFI
		
	By:	 	 /s/ Philippe Goupit



			
		
	Name:	 	 Philippe Goupit



			
		
	Title:	 	 Vice President Corporate Licenses


 SIGNATURE PAGE – AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT 







 List of Appendices 

 

			
	 Appendix 1:
	  	Definitions
		
	 Appendix 2:
	  	Product Specific Patents
		
	 Appendix 3:
	  	Regulus Core Technology Patents
		
	 Appendix 4:
	  	Charter of JSC
		
	 Appendix 5:
	  	Existing Regulus Agreements
		
	 Appendix 6:
	  	Collaboration Targets
		
	 Appendix 7:
	  	Listed Countries
		
	 Appendix 7.3A
	  	Regulus Initial Press Release
		
	 Appendix 7.3B
	  	Sanofi Initial Press Release
		
	 Appendix 8:
	  	R&D Plan
		
	 Appendix 9:
	  	Regulus Detailed Allocation of Upfront Payments








 APPENDIX 1 
 DEFINITIONS 
 “Additional Indication” has the meaning set
forth in Section 6.4.1(c). 
 “Additional Indication Milestone Payment” has the meaning set forth in
Section 6.4.1(c). 
 “Affiliate” means any Person, whether de jure or de facto, which directly or
indirectly through one (1) or more intermediaries controls, is controlled by or is under common control with another Person. A Person will be deemed to “control” another Person if it (a) owns, directly or indirectly, beneficially
or legally, at least 50% of the outstanding voting securities or capital stock (or such lesser percentage which is the maximum allowed to be owned by a Person in a particular jurisdiction) of such other Person, or has other comparable ownership
interest with respect to any Person other than a corporation; or (b) has the power, whether pursuant to contract, ownership of securities or otherwise, to direct the management and policies of the Person. Notwithstanding the above, neither of
the Founding Companies of Regulus will be deemed an Affiliate of Regulus for the purposes of this Agreement under any circumstances. 
 “Agreement” means this Collaboration and License Agreement, together with all Appendices attached hereto, and the R&D Plan, as the same may be amended or supplemented from time to
time in accordance with the terms of this Agreement. 
 “API” means, with respect to a Product, the bulk active
pharmaceutical ingredient for a Licensed Compound manufactured in accordance with GMP for such Product. 
 “Applicable
Law” or “Law” means all applicable laws, statutes, rules, regulations and other pronouncements having the effect of law of any federal, national, multinational, state, provincial, county, city or other political
subdivision, agency or other body, domestic or foreign, including but not limited to any applicable rules, regulations, guidelines, or other requirements of the Regulatory Authorities that may be in effect from time to time, but excluding patent
laws. 
 “Approval” means, with respect to any Product in any regulatory jurisdiction, approval from the
applicable Regulatory Authority sufficient for the manufacture, distribution, use and sale of the Product in such jurisdiction in accordance with Applicable Laws. In jurisdictions where the applicable Regulatory Authority sets the pricing
authorizations necessary for a Product, Approval will not be deemed to have occurred if the final approval to market and sell the Product is being withheld because Sanofi (or its Affiliates or sublicensee) and the Regulatory Authority have not yet
determined pricing; provided, however, that the First Commercial Sale in such jurisdiction will be considered Approval in such jurisdiction. 
 “Business Day” means a day on which banking institutions in New York, New York, United States and Paris, France are both open for business. 

“Calendar Quarter” means the respective periods of three consecutive calendar months ending on March 31,
June 30, September 30 and December 31. 







 “Combination Product” means a Product that includes at least one additional
active ingredient (whether coformulated or copackaged) which is not a Licensed Compound. 
 “Commercialize”,
“Commercializing” and “Commercialization” means activities directed to manufacturing, obtaining pricing and reimbursement approvals, for, marketing, promoting, distributing, importing or selling a Product,
including, without limitation, conducting pre-and post-Approval activities, including studies reasonably required to increase the market potential of the Product and studies to provide improved formulation and Product delivery. 

“Collaboration Target” has the meaning set forth in Section 3.6. 

“Commercially Reasonable Efforts” means, with respect to a Licensed Compound and Product, the carrying out of discovery,
research, Development or Commercialization activities using the efforts that the applicable Party would reasonably devote to a compound or product of similar market potential at a similar stage in development or product life resulting from its own
research efforts, taking into account product profile, the competitive landscape and other relevant scientific, technical and commercial factors. 
 “Companion Diagnostic” means, with respect to a Product, any product or method useful for detecting the applicable Collaboration Target as a biomarker for identifying patient populations
that are better suited to respond to the corresponding Product in the treatment and/or prophylaxis of an approved Indication for the Product. 
 “Confidential Information” has the meaning set forth in Section 7.1. 
 “Control” means, with respect to any Know-How, Patent or other intellectual property right, possession by a Party (including its Affiliates) of the right (whether by ownership, license or
otherwise) to grant to the other Party ownership, a license, sublicense and/or other right to practice under such Know How, Patent or other intellectual property right as provided for herein without violating the terms of any agreement or other
arrangement with any Third Party. Notwithstanding anything to the contrary under this Agreement, with respect to any Third Party acquirer that later becomes an Affiliate of Regulus after the Effective Date, no intellectual property of such Third
Party acquirer will be included in the licenses granted hereunder by virtue of such Third Party acquirer becoming an Affiliate of Regulus. 
 “Cover”, “Covered” or “Covering” means, with respect to a Patent, that, but for rights granted to a Person under such Patent, the practice by such Person
of an invention claimed in such Patent would infringe a Valid Claim included in such Patent, or in the case of a Patent that is a patent application, would infringe a Valid Claim in such patent application if it were to issue as a patent.

 “Development” means non-clinical (such as, but not limited to, IND-enabling toxicology and production of GMP
quality Product) and clinical development activities reasonably related to the development and submission of information to a Regulatory Authority, including, without limitation, chemical synthesis, toxicology, pharmacology, test method development
and stability testing, manufacturing process development, formulation development, delivery system development, quality assurance and quality control development, manufacturing, statistical 







 
analysis, and clinical studies. When used as a verb, “Develop” means to engage in Development. 
 “Development Candidate” has the meaning provided in the R&D Plan. 
 “Disclosing Party” has the meaning set forth in Section 7.1. 

“Discontinued Product” has the meaning set forth in Section 10.1. 

“Dollars” or “$” means the lawful currency of the United States. 

“Effective Date” has the meaning set forth in the opening paragraph of this Agreement. 

“Effective Amendment Date” has the meaning set forth in the opening paragraph of this Agreement. 

“Election Notice” has the meaning set forth in Section 10.1. 

“EMEA” means the European Regulatory Authority known as the European Medicines Agency and any successor agency thereto.

 “EU” means the European Union, as its membership may be altered from time to time, and any successor
thereto, and which, as of the Effective Date, consists of Austria, Belgium, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, The Netherlands, Poland, Portugal,
Slovakia, Slovenia, Spain, Sweden and the United Kingdom, and that certain portion of Cyprus included in such organization. 

“Existing Regulus Agreement” means any of the agreements listed on APPENDIX 5. 

“Existing Sanofi Agreement” means any agreement to which Sanofi is a party as of the Effective Date under which Sanofi
has in-licensed or acquired rights to Patents from a Third Party. 
 “FDA” means the United States Food and
Drug Administration and any successor agency thereto. 
 “Fibrosis” means any organ and/or tissue injury or
repair encompassing multiple biological processes and/or disorders associated with organs and/or tissues as well as wound repair. Examples include, but are not limited to, fibrotic disorders, dermal scarring, wound healing, burns and post-operative
adhesions. 
 “First Commercial Sale” means the first sale of a Product by Sanofi, its Affiliates or a
sublicensee to a Third Party in a particular country after Approval of such Product has been obtained in such country. 







 “Founding Company” means individually, either Isis Pharmaceuticals, Inc. or
Alnylam Pharmaceuticals, Inc.; and collectively, both Isis Pharmaceuticals, Inc. and Alnylam Pharmaceuticals, Inc. 

“Founding Company License Agreement” means the Amended and Restated License and Collaboration Agreement among Regulus
and the Founding Companies dated January 1, 2009, as amended as of the Effective Date. 
 “FTE-Day Rate”
means US $[...***...] per FTE-day, subject to adjustment on an annual basis as of January 1 of each year beginning in 2011 by a factor which reflects changes in the Consumer Price Index for San Diego, California as reported as of
January 1 by the U.S. Department of Labor’s Bureau of Labor Statistics in each applicable year during the Research Term when compared to the comparable statistic for January 1 of the preceding year. The FTE¬Day Rate shall be
inclusive of all allocated overhead costs, administrative expenses and other expenses for the employee(s) providing services under this Agreement, excluding [...***...] costs (which Sanofi will either pay directly or reimburse to Regulus
within 30 days of invoice). 
 “Future Regulus Agreement” has the meaning provided in Section 6.7.2.

 “Future Sanofi Agreement” has the meaning provided in Section 6.7.2. 

“[...***...]” means [...***...]. 

“[...***...]Agreement” means the License Agreement among [...***...] and [...***...] dated
[...***...]. 
 “Generic Product(s)” means a Third Party’s product(s) or Third Parties’
product(s) that has the same or substantially the same active pharmaceutical ingredient as a Product and receives Approval through a regulatory approval process in which either: (i) the applicant for, or sponsor of such Approval; or
(ii) the Regulatory Authority that granted such Approval, relied, in whole or in part, upon [...***...] submitted by, or on behalf of, Sanofi (or its Affiliate or sublicensee), to any Regulatory Authority, to support the Approval of a
Product. 
 “Good Clinical Practice” or “GCP” will mean the then current standards for
clinical trials for pharmaceuticals, as set forth in the United States Code of Federal Regulations, ICH guidelines and applicable regulations, laws or rules as promulgated thereunder, as amended from time to time, and such standards of good clinical
practice as are required by the European Union and other organizations and governmental agencies in countries in which a Licensed Product is intended to be sold to the extent such standards are not less stringent than United States GCP. 

“Good Laboratory Practice” or “GLP” will mean the then current standards for laboratory activities for
pharmaceuticals, as set forth in the FDA’s GLP regulations and/or ICH guidelines and applicable regulations. 

“Good Manufacturing Practice(s)” or “GMP” will mean the regulatory requirements for current good
manufacturing practices promulgated in the United States Code of Federal Regulations including those rules promulgated by the United States Food and Drug 

  
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Administration under the U.S. Food, Drug and Cosmetic Act, 21 C.F.R. § 210 et seq., and ICH Guidelines and applicable regulations, as the same may be amended from time to time. 

“[...***...]” means the [...***...] Agreement dated [...***...], between [...***...] and
[...***...], as amended. 
 [...***...] 
 “IND” means an Investigational New Drug Application (as defined in the Food, Drug and Cosmetic Act, as amended) filed with the FDA or its foreign counterparts. 

“IND Approval” means the acceptance (or deemed acceptance) of the filing of an IND by the applicable Regulatory
Authority. For purposes of clarity, acceptance (or deemed acceptance) of the filing of the foreign equivalent of an IND by the applicable Regulatory Authority in such country will be an IND Approval. 

“IND-Enabling Studies” means the pharmacokinetic and toxicology studies required to meet the regulations for filing an
IND. 
 “Indemnified Party” has the meaning set forth in Section 11.3. 

“Indemnification Claim Notice” has the meaning set forth in Section 11.3. 

“Indication” means mean any human or animal disease or condition, or sign or symptom of a human or animal disease or
condition. 
 “Initiation of Phase 1 Trial” means the dosing of the first human subject in a Phase 1 Trial.

 “Initiation of Phase 2 Trial” means the dosing of the first human subject in the first Phase 2 Trial.

 “Initiation of Phase 3 Trial” means the dosing of the first human subject in a Phase 3 Trial. In the case
where a Phase 2b/3 Trial precedes any Phase 3 Trial for a given Product, the first dosing of such Product in a human subject following the review of interim data and decision to extend the period of such Phase 2b/3 Trial in order to provide
sufficient evidence of safety and efficacy to be included as a Phase 3 Trial in filings with Regulatory Authorities will be deemed to be the “start of Phase 3 Trial” for such Product. 

“In-License Milestones” means, with respect to a particular Third Party Agreement, all milestone payments that become
payable by a Party to the Licensor(s) under such Third Party Agreement with respect to the applicable Third Party Patents as a result of the achievement of Development, regulatory and/or Commercialization events by a Product. For clarity,
“In-License Milestones” shall not include any upfront payments under Third Party Agreements. 

  
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 “In-License Royalties” means, with respect to a particular Third Party
Agreement, all royalties on sales of Products by Sanofi, its Affiliates and its sublicensees that become payable by a Party to the Licensor(s) under such Third Party Agreement with respect to the applicable Third Party Patents. 

“Integrated Product Plan” or “IPP” has the meaning set forth in Section 5.3. 

“Intellectual Property Panel” has the meaning set forth in Section 6.7.1. 

“Joint Invention” has the meaning set forth in Section 8.1. 

“Joint Patent” means any Patent that claims, and only to the extent that it claims, a Joint Invention(s). 

“JSC Charter” has the meaning set forth in Section 3.4. 

“JSC” has the meaning set forth in Section 3.4. 

“Know-How” means technical information and materials, including without limitation, technology, software,
instrumentation, devices, data, biological materials, assays, constructs, compounds, inventions, practices, methods, knowledge, know-how, trade secrets, skill and experience. 
 “Licensed Compound” means either (i) with respect to any Collaboration Target identified on APPENDIX 6 as approached via a microRNA Antagonist,
any microRNA Antagonist that modulates the expression of such Collaboration Target where its primary mechanism of action is [...***...], or (ii) with respect to any Collaboration Target identified on APPENDIX 6 as
approached via a microRNA Mimic, a microRNA Mimic with a substantially similar base composition as such Collaboration Target and which is designed to mimic the activity of such Collaboration Target. For purposes of clarity, so long as Mir-21 remains
a Collaboration Target, a Mir-21 Compound will be a Licensed Compound under this Agreement. 
 “Licensing
Revenues” has the meaning set forth in Section 10.2. 
 “Licensor” means, with respect to a
particular Third Party Agreement, any Third Party that is a party to such Third Party Agreement. 
 “Losses”
has the meaning set forth in Section 11.1. 
 “Major European Country” means France, Germany, Italy, Spain
or the United Kingdom. 
 “Major Market Country” means Canada, France, Germany, Italy, Japan, Spain, the United
Kingdom, and the United States. 
 “Manufacturing Technology” has the meaning set forth in Section 4.3.


  
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 “microRNA” means a structurally defined functional RNA molecule usually
between 21 and 25 nucleotides in length, which is derived from genetically-encoded non-coding RNA which is predicted to be processed into a hairpin RNA structure that is a substrate for the double-stranded RNA-specific ribonuclease Drosha and
subsequently is predicted to serve as a substrate for the enzyme Dicer, a member of the RNase III enzyme family; including, without limitation, those microRNAs exemplified in miRBase (http://microrna.sanger.ac.uk/). To the extent that
[...***...] for purposes of this Agreement; provided, however, that nothing contained herein will require any Party hereto to [...***...]. 
 “microRNA Antagonist” means a single-stranded oligonucleotide (or a single stranded analog thereof) that is designed to interfere with or inhibit a particular microRNA. For purposes of
clarity, the definition of “microRNA Antagonist” excludes oligonucleotides that function predominantly through the RNAi mechanism of action or the RNase H mechanism of action. 

“microRNA Compound” means a compound consisting of (a) a microRNA Antagonist, or (b) a microRNA Mimic.

 “microRNA Mimic” means a double-stranded or single-stranded oligonucleotide or analog thereof with a
substantially similar base composition as a particular microRNA and which is designed to mimic the activity of such microRNA. 

“Mir-21” means the microRNA having (i) miRBase ID: hsa-miR-21; (ii) the miRBase Accession Number MIMAT0000076,
and (iii) the sequence UAGCUUAUCAGACUGAUGUUGA. 
 “Mir-21 Compound” means any microRNA Antagonist that
modulates the expression of Mir-21 whose primary mechanism of action is through [...***...] to Mir-21. 
 “Mir-21
Product” means any pharmaceutical product containing a Mir-21 Compound (alone or with other active ingredients), in all forms, presentations, formulations and dosage forms. 

“NDA” means a New Drug Application filed with the FDA after completion of clinical trials to obtain marketing approval
for the applicable Product in the United States. 
 “NDA Filing” means the acceptance by the FDA of the filing
of an NDA for the applicable Product, or the acceptance of the foreign equivalent of an NDA by the applicable Regulatory Authority. 
 “Necessary Patent” has the meaning provided in Section 6.7.1. 
 “Net Sales” means, with respect to a Product, the gross invoice price of all units of such Products sold by Sanofi, its Affiliates and/or their sublicensees to any Third Party, less the
following items: (a) trade discounts, credits or allowances, (b) credits or allowances additionally granted upon returns, rejections or recalls, (c) freight, shipping and insurance charges, (d) taxes, duties or other governmental
tariffs (other than income taxes), (e) government-mandated rebates, 

  
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and (f) a reasonable reserve for bad debts. “Net Sales” under the following circumstances will mean the fair market value of such Product: (i) Products which are used by
Sanofi, its Affiliates or sublicensees for any commercial purpose without charge or provision of invoice, (ii) Products which are sold or disposed of in whole or in part for non cash consideration, or (iii) Products which are provided to a
Third Party by Sanofi, its Affiliates or sublicensees without charge or provision of invoice and used by such Third Party except in the cases of Products used to conduct clinical trials, reasonable amounts of Products used as marketing samples and
Product provided without charge for compassionate or similar uses. 
 Net Sales will not include any transfer between or among
Sanofi and any of its Affiliates or sublicensees for resale. 
 In the event a Product is sold as part of a Combination Product,
the Net Sales from the Combination Product, for the purposes of determining royalty payments, will be determined by multiplying the Net Sales (as determined without reference to this paragraph) of the Combination Product, by the fraction, A/(A+B),
where A is the average sale price of the Product when sold separately in finished form and B is the average sale price of the other therapeutically active pharmaceutical compound(s) included in the Combination Product when sold separately in
finished form, each during the applicable royalty period or, if sales of all compounds did not occur in such period, then in the most recent royalty reporting period in which sales of all occurred. In the event that such average sale price cannot be
determined for both the Product and all other therapeutically active pharmaceutical compounds included in the Combination Product, Net Sales for the purposes of determining royalty payments will be calculated as above, but the average sales price in
the above equation will be replaced by a good faith estimate of the fair market value of the compound(s) for which no such price exists. 
 “New Core Patents” has the meaning set forth in Section 6.9. 

“New Core Technology” has the meaning set forth in Section 6.9. 

“New Core Technology Agreement” has the meaning set forth in Section 6.9. 

“Objective” means the objective of the R&D Plan set forth in Section 3.1. 

“Other In-License Payments” means, with respect to a particular Third Party Agreement, all payments
(excluding In-License Royalties and In-License Milestones) that become payable by a Party to the applicable Licensor(s) under such Third Party Agreement with respect to the applicable Third Party Patents. 

“Other Licensor” means any Licensor that is not a Founding Company. 

“Other Party” has the meaning set forth in Section 9.3. 

“Party(ies)” has the meaning set forth in the opening paragraph of this Agreement. 

“Patents” means (a) patents and patent applications in any country or jurisdiction, (b) all priority
applications, divisionals, continuations, and continuations-in-part of any of the foregoing, and (c) all patents issuing on any of the foregoing patent applications, together with 

  








 
all registrations, reissues, renewals, re-examinations, confirmations, supplementary protection certificates, and extensions of any of (a), (b) or (c). 

“Permitted License” means a license granted by Regulus to a Third Party (i) under the Regulus Core Technology
Patents (but not under the Product Specific Patents) to [...***...] (or [...***...] to [...***...]) solely to conduct Research, or (ii) under the Regulus Core Technology Patents (but not under the Product Specific Patents) to
enable such Third Party to [...***...] or [...***...] microRNA Compounds, where such Third Party is [...***...] and is not [...***...] or [...***...]. 

“Person” means any individual, firm, corporation, partnership, limited liability company, trust, business trust, joint
venture company, governmental authority, association or other entity. 
 “Phase 1 Trial” means the initial
clinical testing of a Product in humans (first-in-humans study) with the intention of gaining a preliminary assessment of the safety of such Product. 
 “Phase 2 Trial” means a human clinical trial of a Product, the principal purpose of which is a determination of preliminary short-term safety and efficacy in the target patient
population, as described in 21 C.F.R. 312.21(b) for the United States, or a similar clinical study prescribed by the Regulatory Authorities in a foreign country. 
 “Phase 2b/3 Trial” means a human clinical trial of a Product, the principal purpose of which is a further determination of efficacy and safety, in the target population, at the intended
clinical dose or doses or range of doses, on a sufficient number of subjects and for a sufficient period of time to confirm the optimal manner of use of the Product (dose and dose regimen) prior to initiation of the pivotal Phase 3 Trials, and which
itself provides sufficient evidence of safety and efficacy to be included as a Phase 3 Trial in filings with Regulatory Authorities. 
 “Phase 3 Trial” means a human clinical trial of a Product on a sufficient number of subjects that is designed to establish that a pharmaceutical product is safe and efficacious for its
intended use, and to determine warnings, precautions and adverse reactions that are associated with such pharmaceutical product in the dosage range to be prescribed, which trial is intended to support Approval of a Product, as described in 21 C.F.R.
312.21(c) for the United States, or a similar clinical study prescribed by the Regulatory Authorities in a foreign country. 

“Phase 4 Trial” means a human clinical trial for a Product commenced after receipt of Approval in the country for which
such trial is being conducted and that is conducted within the parameters of the Approval for the Product. Phase 4 Trials may include, without limitation, epidemiological studies, modeling and pharmacoeconomic studies, investigator sponsored
clinical trials of Product and post-marketing surveillance studies. 
 “Product” means any pharmaceutical
product containing a Licensed Compound (alone or with other active ingredients), in all forms, presentations, formulations and dosage forms. 
 “Product Development Plan” has the meaning set forth in Section 5.3. 

  
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 “Product Field” means (a) with respect to Licensed Compounds and
Products, the treatment and/or prophylaxis of any Indication and (b) with respect to Companion Diagnostics, to the extent that Regulus Controls [...***...] the applicable Collaboration Target as [...***...] for [...***...] to
the corresponding Product in the treatment and/or prophylaxis of an approved Indication for the Product. 
 “Product
Specific Patents” means all Patents (including all claims and the entire scope of claims therein) Controlled by Regulus or its Affiliates on the Effective Date and/or at any time thereafter, in each case claiming (a) a Collaboration
Target gene sequence or a portion thereof, (b) the specific compositions of matter of Licensed Compounds or Products, or (c) methods of using Licensed Compounds or Products as therapeutics; provided however, that: 

(1) unless the Parties otherwise agree in writing, Patents that include claims that are directed to subject matter and have a
scope that is applicable to microRNA Compounds in general, and not directed solely to [...***...] or [...***...] or to the [...***...] thereof, will be considered to be [...***...] Patents; and 

(2) unless the Parties otherwise agree in writing, Patents that include claims that are directed to the identification or
isolation of microRNAs that are not [...***...], or to the production, composition, or use of [...***...] that are not [...***...] or [...***...], will be considered to be [...***...] Patents. 

For clarification, any Regulus Program Patent or any Joint Patent satisfying the definition above, will be considered a Product Specific
Patent. The Product Specific Patents as of the Effective Date are listed in APPENDIX 2 attached hereto. 

“Program Inventions” has the meaning set forth in Section 8.1. 

“Program Patents” has the meaning set forth in Section 8.1. 

“Proposed Target” has the meaning set forth in Section 3.6. 

“R&D Plan” has the meaning set forth in Section 3.2. 

“Receiving Party” has the meaning set forth in Section 7.1. 

“Regulatory Authority” means any governmental authority, including without limitation FDA, EMEA or Koseisho (i.e., the
Japanese Ministry of Health, Labour and Welfare, or any successor agency thereto), that has responsibility for granting any licenses or approvals or granting pricing and/or reimbursement approvals necessary for the marketing and sale of a Product in
any country. 
 “Regulatory Documentation” means all applications, registrations, licenses, authorizations and
approvals (including all Approvals), all correspondence submitted to or received from Regulatory Authorities (including minutes and official contact reports relating to 

  
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any communications with any Regulatory Authority), all supporting documents and all clinical studies and tests, including the manufacturing batch records, relating to the Product, and all data
contained in any of the foregoing, including all regulatory drug lists, advertising and promotion documents, adverse event files and complaint files. 
 “Regulus Confidential Information” means any Confidential Information for which Regulus is the Disclosing Party. 
 “Regulus Core Technology Patents” means, subject to 6.8.3, Patents Controlled by Regulus or its Affiliates on the Effective Date and/or at any time thereafter, in each case that are
useful or necessary for the Development and Commercialization of Licensed Compound and Products. Regulus Core Technology Patents will exclude the Product Specific Patents. A representative list of the Regulus Core Technology Patents as of the
Effective Date is listed in APPENDIX 3 hereto. For clarification, any Regulus Program Patent or any Joint Patent satisfying the definition above will be considered a Regulus Core Technology Patent. 

“Regulus Database” has the meaning set forth in Section 3.11. 

“Regulus Inventions” has the meaning set forth in Section 8.1. 

“Regulus Know-How” means all Know-How Controlled by Regulus or its Affiliates as of the Effective Date and/or at any
time thereafter that is useful for the Research, discovery, Development, Approval, manufacturing and Commercialization of microRNA Compounds. 
 “Regulus Patents” means the Regulus Core Technology Patents and the Product Specific Patents (including patents licensed to Regulus under an Existing Regulus Agreement, or under a Future
Regulus Agreement in accordance with Section 6.7). 
 “Regulus Program Patent” has the meaning set forth
in Section 8.1. 
 “Regulus Target” means any Collaboration Target that, at the time of Regulus’
receipt of Sanofi’s Request Notice for such microRNA pursuant to Section 3.6.1, (i) is a Proposed Target with respect to which Regulus has identified at least one lead-stage microRNA Compound having activity as a microRNA Antagonist
or microRNA Mimic (as applicable) to such Proposed Target in a Therapeutic Field, as demonstrated by in-vivo study results, and (ii) has been approved in accordance with Regulus’ internal procedures, consistently applied to all
Regulus research programs, as the subject of an internal Regulus research program, conducted entirely independently of the Research Program, with committed resources, as reflected in the minutes of the proceedings of Regulus’ Program Review
Committee. For purposes of this definition, “Program Review Committee” has the meaning set forth in Section 3.6.1(b). 
 “Regulus Technology” means collectively, the Regulus Know-How and the Regulus Patents. 
 “Requested Target” has the meaning set forth in Section 3.6.1. 







 “Research” means pre-clinical research including gene function, gene
expression and target validation research using cells and animals, which may include small pilot toxicology studies but excludes IND-Enabling Studies, clinical development and commercialization. 

“Research Program” has the meaning set forth in Section 3.1. 

“Research Results” means all data, information, trade secrets, inventions and Know-How which are discovered, made,
reduced to practice, identified or developed in whole or in part by Regulus in the course of the performance of the Research Program and Development Program. 
 “Research Term” has the meaning set forth in Section 3.3.1. 

“Royalty Term” has the meaning set forth in Section 6.11. 

“Sanofi Confidential Information” means any Confidential Information for which Sanofi is the Disclosing Party.

 “Sanofi Indemnitees” has the meaning set forth in Section 11.2. 

“Sanofi Inventions” has the meaning set forth in Section 8.1. 

“Sanofi Product Specific Patent” means any Patents (including all claims and the entire scope of claims therein)
Controlled by Sanofi or its Affiliates on the Effective Date and/or at any time thereafter, in each case claiming (a) the sequence or a portion thereof corresponding to the Mir-21 or Collaboration Target gene sequence or a portion thereof,
(b) the specific composition of matter of a Product, (c) methods of using a Licensed Compound or Product as a therapeutic or (d) methods of using a Licensed Compound as a therapeutic). 

“Sanofi Program Patents” has the meaning set forth in Section 8.1. 

“Senior Representatives” has the meaning set forth in Section 13.4.1. 

“Stock Purchase Agreement” means that certain letter agreement between the Parties dated as of the Effective Date
pursuant to which Sanofi is purchasing shares of Regulus’ Series B preferred stock. 
 “Target
Encumbrances” has the meaning set forth in Section 3.6.1. 
 “Target Field” means (a) the
treatment and/or prophylaxis of any or all Indications in Fibrosis [...***...] and (b) to the extent that Regulus Controls [...***...] the applicable Collaboration Target as [...***...] for [...***...] to the
corresponding Licensed Compound in the treatment and/or prophylaxis of an Indication in Fibrosis [...***...]. 

“Target Product Profile” means, with respect to each Collaboration Target, the description, as established by the JSC,
of the commercially relevant range of acceptable product performance of a Collaboration Compound against key product characteristics (including but not 

  
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limited to efficacy, safety, quality, side effects, tolerability, route of administration, contraindications and clinical endpoints), and which shall be used by the Parties to guide and shape the
progression of and development decisions for such Licensed Compound to achieve IND approval. 
 “Technology Alliance
Agreement” means the Non-Exclusive Technology Alliance and Option Agreement between the Parties dated as of the Effective Date. 
 “Term” has the meaning set forth in Section 9.1. 

“Territory” means all countries and jurisdictions throughout the world. 

“Therapeutic Field” means any field concerning the remediation of a health problem, including Fibrosis,
[...***...], oncology, diabetes, cardiovascular, ophthalmology, central nervous system, internal medicine, thrombosis, and vaccines. 
 “Third Party” means any Person other than Regulus or Sanofi or their respective Affiliates. 
 “Third Party Agreement” means an Existing Regulus Agreement, Future Regulus Agreement, Existing Sanofi Agreement or Future Sanofi Agreement, as applicable. 

“Third Party Claims” has the meaning set forth in Section 11.1. 

“Third Party Patents” means, with respect to a particular Third Party Agreement, all Necessary Patents that a Party
in-licenses or acquires from the Licensor(s) under such Third Party Agreement. 
 “[...***...]
Patents” means all Patents licensed under the [...***...] Agreement. 
 “Valid Claim” means a
claim of any issued, unexpired patent that has not been revoked or held unenforceable or invalid by a decision of a court or governmental agency of competent jurisdiction from which no appeal can be taken, or with respect to which an appeal is not
taken within the time allowed for appeal, and that has not been disclaimed or admitted to be invalid or unenforceable through reissue, disclaimer or otherwise. 
 “[...***...]” means [...***...]. 

“[...***...] Agreement” means the [...***...] Agreement by and between the [...***...],
commissioned by [...***...], and Regulus dated [...***...]. 

  
 ***Confidential
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 APPENDIX 2 
 PRODUCT-SPECIFIC PATENTS 
 [Attached] 







 APPENDIX 2 
 PRODUCT-SPECIFIC PATENTS 
 (as of the Effective Amendment Date)

 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 2 
 [...***...] 

  
 ***Confidential
Treatment Requested 
 2 








 APPENDIX 2 
 [...***...] 

  
 ***Confidential
Treatment Requested 
 3 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [Attached] 







 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 (as of the Effective Amended Date)

 Patents and Patent Applications owned by or licensed to Regulus 

[...***...] 

  
 ***Confidential
Treatment Requested 
 1 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENT 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENT 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 Patents and Patent Applications
Licensed to Regulus by Isis 
 [...***...] 

  
 ***Confidential
Treatment Requested 
 4 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 Patents and Patent Applications
Licensed to Regulus by Alnylam 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 3 
 REGULUS CORE TECHNOLOGY PATENTS 
 [...***...] 

  
 ***Confidential
Treatment Requested 








 APPENDIX 4 
 CHARTER OF THE JOINT STEERING COMMITTEE 
 Purpose 

The Joint Research Committee is established by Regulus and Sanofi to oversee the Research Program under the Agreement. 

Responsibilities 
 1. The JSC
will, using the R&D Plan initially agreed to on the Effective Date, as a basis, continue to develop and refine the R&D Plan, as needed, and will conduct a comprehensive review of the R&D Plan on at least an annual basis. 

2. The JSC will be responsible for the overall planning and execution of the Research Program and the approval and oversight of the R&D Plan. The JSC
will (i) evaluate the data generated by the Parties in the course of carrying out the R&D Plan, (ii) discuss and resolve any overarching issues or significant changes in the R&D Plan, (iii) recommend project prioritization
within the R&D Plan, (iv) make project progression decisions and resource allocation decisions in accordance with the R&D Plan, (v) make revisions to the R&D Plan as necessary and (vi) consistent with Article 7 of the
Agreement, review and approve all public communications and disclosures, including but not limited to data presented at external meetings and journals on the joint Research Results. Except for amendments to the R&D Plan (as adopted in accordance
with this charter and the Agreement), in no event will the JSC have the power or authority to amend any provision of the Agreement. 
 3. The
JSC will have the power to delegate its authority and duties to sub-committees as it deems appropriate. 
 Composition 

4. The JSC will initially have six members, and will at all times have an equal number of members designated by each Party. Each Party may replace its
appointed JSC representatives at any time upon written notice to the other Party. The size and composition of the JSC provided herein may not be changed without the consent of both Regulus and Sanofi. 

5. Each JSC member will have the requisite background, experience and training to carry out the duties and obligations of the JSC. 

6. Each Party will designate one of its representatives as co-chairperson of the JSC. Each of the co-chairpersons will be responsible, on an alternating
basis with the Sanofi co-chairperson having responsibility with respect to the initial meeting, for scheduling meetings, preparing and circulating an agenda in advance of each meeting, and preparing the minutes of each meeting. 

  
 1 








 Decisions 
 7. Each Party’s JSC members will collectively have three votes, regardless of the number of its JSC members participating in any meeting. No votes will be taken unless there is at least one JSC
member representing each of Regulus and Sanofi participating in such meeting. Each Party may allocate its three votes among its attending JSC members in any manner, at such Party’s discretion. If only one JSC member is attending on behalf of a
given Party, such JSC member may cast all the votes allocated to such Party. Unless otherwise specified herein, all actions taken by the JSC as a committee will be by majority vote. If the JSC members reach a deadlock on any vote, then the deadlock
will be resolved in accordance with Paragraph 8 below. Notwithstanding anything to the contrary, no decision by the JSC will require the other Party to: (i) breach any written agreement that such other Party may have with a Third Party (except
where such agreement is entered into in breach of any representation, warranty, covenant or obligation of such Party under to this Agreement); (ii) perform any activities that are outside the scope of the Objective; or (iii) violate any
Applicable Law or principles of scientific integrity. 
 8. If the JSC is unable to decide by a majority vote on any issue within the scope of
its authority and duties, then the JSC will promptly raise such issue to each Parties co-chairperson on the JSC, and such co-chairs will have 10 days to mutually agree on how to resolve such issue. If the co-chairs are unable to resolve such issue
within the 10 day period, then such issue will be brought to each Party’s Senior Representatives, or their designees. The Senior Representatives will have 10 days to mutually agree on how to resolve such issue. If the Senior Representatives are
unable to resolve such issue within the 10-day period, then, subject to the express limitations set forth in the Agreement and in Paragraph 9 below, such issue will be finally resolved by the Senior Representative of Sanofi, and such resolution will
be binding on Sanofi and Regulus. 
 9. Notwithstanding anything to the contrary, Sanofi will not have the final decision with respect to any
dispute involving changing (a) the R&D Plan to increase the scope or include new technology (e.g., [...***...]) other than upon the designation of a new Collaboration Target, pursuant to Section 3.6.1, or (b) the
[...***...] after [...***...] have begun, all of which changes in the aggregate would cumulatively increase Regulus’ fully burdened costs of performing R&D Plan activities for a given Collaboration Target by more
than a total of $[...***...], unless [...***...] in costs in excess of $[...***...] for such Collaboration Target; and (iii) whether to drop or replace a Collaboration Target during the first
[...***...] months following the applicable Request Notice for such Collaboration Target. 
 Operations; Meetings

 10. During the Research Term the JSC will initially meet once per month, unless and until the JSC determines that such meetings should
occur once per Calendar Quarter (in either case, each a “Scheduled Meeting”). Scheduled Meetings may be held in person or by audio or video teleconference when appropriate, but at a minimum, once each year in person (which
in-person meeting will be held on an alternating basis in New York, NY and in Carlsbad, CA). In addition, any two members of the JSC may jointly call for an ad hoc meeting of the JSC by teleconference at any time, by giving the other members
of the JSC advance written notice of at least two 

  
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 Business Days (each, an “Ad Hoc Meeting”). An Ad Hoc Meeting may be called to
address any time-sensitive matter. 
 11. Meetings of the JSC will be effective only if at least one JSC representative of each Party is present
or participating. Each Party will be responsible for all of its own expenses of participating in the JSC meetings. The Parties will endeavor to schedule meetings of the JSC with at least 30 days advance notice. 

12. Each Party may bring additional employees to each meeting as non-voting observers. 
 13. The co-chair responsible for each meeting (the “Responsible Chair”) will, in consultation with other members of the JSC, develop and set the JSC’s agenda for each
Scheduled Meeting. The Responsible Chair will include on such agenda each item requested within a reasonable time in advance of such Scheduled Meeting by a JSC member. The agenda and information concerning the business to be conducted at each
Scheduled Meeting will be communicated in writing to the members of the JSC within a reasonable time in advance of such Scheduled Meeting to permit meaningful review. No agenda is required for an Ad Hoc Meeting. 

14. The Responsible Chair, or such person as the Responsible Chair may designate, will prepare, and distribute to all JSC members, draft committee
minutes within 2 weeks following each Scheduled Meeting or Ad Hoc Meeting and such minutes will be finalized by the JSC promptly thereafter. As part of the agenda of the first Scheduled Meeting, the JSC members will agree upon a standard procedure
for review and approval of such draft committee minutes by the JSC. 

  
 3 








 APPENDIX 5 
 EXISTING REGULUS AGREEMENTS 
 This Appendix 5 contains a list of certain
agreements in effect as of the Effective Date between Regulus and certain Third Parties that may, as applicable, place certain encumbrances or limitations on the licenses or sublicenses granted to Sanofi, the exclusivity covenants, and the
representations and warranties, where specified in the Agreement. 
 As set forth in the Agreement, the information and
disclosures contained in this Appendix 5 are intended only to qualify and limit the licenses granted by Regulus to Sanofi, the exclusivity covenants, and the representations and warranties given by Regulus under the Agreement and do not expand
in any way the scope or effect of any such licenses, representations or warranties. 
 Nothing herein constitutes an admission
of any liability or obligation of Regulus nor an admission against any interest of Regulus. The inclusion of this Appendix 5 or the information contained in this Appendix 5 does not indicate that Regulus has determined that this Appendix 5 or the
information contained in this Appendix 5, when considered individually or in the aggregate, is necessarily material to Regulus. 

Existing Regulus Agreements 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 

 

	*	Note: these agreements are not applicable on the Effective Date, and would only apply if Sanofi designates a Collaboration Target under Section 3.6 that is covered
by the Patents in-licensed by Regulus under such agreements. 


  
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 APPENDIX 6 
 COLLABORATION TARGETS 
  

							
	Target
No.	 	microRNA
Name	 	 miRBase
 Accession No
	 	 Approached via
microRNA Antagonist

or microRNA Mimic

				
	1	 	Mir-21	 	MIMAT0000076	 	microRNA Antagonist
				
	2	 		 		 	
				
	3	 		 		 	
				
	4	 		 		 	








 APPENDIX 7 
 LISTED COUNTRIES 
  

			
	 Patent Country Code
	  	 Patent Filing Country or Jurisdiction

	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]


  
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 APPENDIX 8 
 INITIAL R&D PLAN 
 [Attached] 







  
 RESEARCH AND DEVELOPMENT PLAN 
 between 

REGULUS THERAPEUTICS, INC. 
 and 
 SANOFI-AVENTIS 

 
  

  

			
	17 June 2010	 	CONFIDENTIAL

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Regulus and Sanofi Collaboration on Fibrosis and [...***...] 

 
  
 The initial research and development plan (the “R&D Plan”) described below outlines the current research objectives under the Collaboration and License Agreement dated June 14, 2010
between Sanofi and Regulus. Capitalized terms used and not defined herein shall have the meanings set forth in the Agreement. In case of any conflicts between this initial R&D Plan and the Agreement, the terms of the Agreement shall govern. As
stated in the Agreement, the Joint Steering Committee (JSC) has the right to amend the R&D Plan at any time during the Research Term. 

Objective: Regulus and Sanofi will collaborate in the discovery and preclinical development of microRNA therapeutics for the clinical development
and commercialization of such microRNA therapeutics by Sanofi. 
 Purpose of the initial R&D Plan: The purpose of this R&D Plan
is to outline the responsibilities and activities of Regulus and Sanofi with respect to carrying out the research and preclinical development of microRNA therapeutics so as to provide broad guidance to the scientific team in carrying out their work.
The initial R&D Plan contains a summary description of the potential specific activities, deliverables, and projected timelines for completion of such activities; and is subject to the modification by the JSC. 

Collaboration Management: The R&D Plan will be overseen and managed by the JSC. The R&D Plan may only be amended with the unanimous
approval of the JSC (as permitted by the JSC Charter). The R&D Plan may be amended at any time, and is expected to be reviewed at least annually. The Parties have created and agreed to the initial R&D Plan as a basis for the research and
preclinical development of microRNA therapeutics and it is the intent of Regulus and Sanofi to subsequently modify the initial R&D Plan in a manner to successfully develop microRNA therapeutics. Both Parties shall use Commercially Reasonable
Efforts to complete the activities listed in the R&D Plan as promptly and diligently as possible. 
 Research Term: The R&D Plan
will be carried out during the period following the Effective Date and ending on the third anniversary of the Effective Date, unless otherwise extended as described in the Agreement. For any extension of the Research Term, the JSC will amend and
restate the R&D Plan as necessary, subject to the provisions of the JSC Charter. 
 Research Program Staffing and Resources: As
described in the Agreement, Regulus will dedicate Regulus employees during the Research Term to perform the activities of the R&D Plan. Regulus resources will include the following: bioinformatics, basic mechanisms, exploratory biology,
in vitro and in vivo biology, chemistry, and translational medicine. Sanofi and Regulus will cooperate with each other in carrying out the R&D Plan and each Party will contribute its relevant know-how
and experience necessary. It is contemplated that the Parties will work closely together and, where applicable, Sanofi will contribute scientific expertise, assays and animal models, as defined in the Agreement (Article 3.5.2). If appropriate,
experts from Sanofi are invited to visit the laboratories of Regulus and participate in the ongoing research activities. 

  

			
	17 June 2010	 	CONFIDENTIAL
		
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 Definitions: 
 Program Candidates – [...***...] 
 Research Candidates – [...***...]

 Development Candidate – [...***...] 
 EXECUTIVE SUMMARY: 
 The overall goal of the R&D Plan is to provide the framework for a
microRNA therapeutic “IND Engine” that can achieve an IND for miR-21 in [...***...] followed by several other potential INDs for microRNA therapeutics in [...***...]. We have provided a proposed timeline of these activities
shown in the figure below. 
 [...***...] 
 The initial R&D Plan is organized into four sections, which may have activities that overlap. Each section has clearly defined objectives, tasks/activities, and deliverables to achieve the goals of
selecting three Collaboration Targets (other than miR-21) and an IND for anti-miR-21 by [...***...]. 
 The initial R&D Plan has been
written to reflect a flow from early stage to late stage activities within any given program. The timeline highlights when these activities actually occur across the programs and emphasizes that the first key task of the Collaboration is to produce
an IND for miR-21. That being said, the four sections of the R&D Plan are: 

  

			
	17 June 2010	 	CONFIDENTIAL
		
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 Section I. Designating Collaboration Targets in Fibrosis; 

Section II. [...***...]; 
 Section III. [...***...]; and 
 Section IV. [...***...]. 

Briefly, Sections I [...***...] describe efforts to identify and designate Collaboration Targets in Fibrosis [...***...]. A detailed R&D
plan for projects in [...***...] will be written and approved by the JSC by [...***...]. 
 As per the Agreement, Sanofi will
designate its four Collaboration Targets within [...***...] of the Research Term (the Target Designation Period). Regulus will be responsible for identifying and validating the Collaboration Targets using the criteria listed below
[...***...]. In addition, Regulus will perform [...***...]. Following Collaboration Target selection, Sanofi will have the right to substitute Collaboration Targets during a period of [...***...] months following designation and in
accordance with the Agreement. 
 Section III describes the basic workflow for [...***...]. 

Finally, Section IV describes [...***...]. 
 DETAILS OF THE INITIAL R&D PLAN: 
 Section I. Designating Collaboration Targets in
Fibrosis 
 Overview: The basic hypothesis is that microRNAs [...***...]. Regulus scientists have been working closely with a
network of leading academic collaborators [...***...]. 
 REGULUS NETWORK OF ACADEMIC COLLABORATORS FOR FIBROSIS 

 

			
	 Name & Institute
	  	 Fibrosis area focus

	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]
	[...***...]	  	[...***...]


  

			
	17 June 2010	 	CONFIDENTIAL
		
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 From these collaborations [...***...]. We have determined microRNA [...***...]. We have also
[...***...]. The [...***...] approach offers the advantage that [...***...]. 
 [...***...] 

[...***...] 
 [...***...].

 Specific Activities: 

Goal 1: Identify Collaboration Targets in Fibrosis 
 (I)  Identify potential microRNA therapeutic targets in Fibrosis 

a.    [...***...] 

  

			
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 [...***...] 
 [...***...] 
 Deliverable 1: [...***...] 

Goal 2: [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 

Deliverable 2: [...***...] 

Section II. [...***...] 

Overview: [...***...] 

[...***...]. 

  

			
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 Specific Activities: 
 Goal 3: [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...]

 [...***...] 
 [...***...] 
 [...***...] 

[...***...] 

[...***...] 
 The basic workflow for
Sections I and II is shown below: 
 [...***...] 
 Figure 1. Workflow for identification and validation of Collaboration Targets in Fibrosis [...***...] 

  

			
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 Deliverables for Sections I and II: 

 

			
	 Deliverables
	  	 Timing

	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]

 Section III. [...***...] 
 Overview: [...***...] 
 [...***...] 

[...***...] 
 [...***...]

 [...***...] 

  

			
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 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 

  

			
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 [...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...]

 [...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 

[...***...] 
 Deliverables for Sections
III: [...***...] 
  

			
	 Deliverables
	  	 Timing

	 [...***...]
	  	[...***...]
	 [...***...]
	  	[...***...]
	 [...***...]
	  	[...***...]
	 [...***...]
	  	[...***...]

 Section IV. [...***...] 
 [...***...]. 

  

			
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 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 

  

			
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 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 

  

			
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 [...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 

[...***...] 
  

					
	 Deliverable
	  	 Criteria
	  	 Timing

	 9.        [...***...]
	  	[...***...]	  	[...***...]

 Development Candidate Selection Criteria 
 If the miRNA antagonist or miRNA mimetic achieves the following profile, it will be considered for Development Candidate status: 
 [...***...] 
 [...***...] 

[...***...] 

[...***...] 

[...***...] 
  

			
	 Criteria
	  	 Regulus

		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]


  

			
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	[...***...]	  	[...***...]

 Table 1. Considerations for Development Candidate selection 
 Key IND-Enabling Activities 
 After a Development Candidate has been selected, Regulus will
conduct appropriate IND-enabling activities to support the miRNA antagonist for clinical trials. The Workflow is provided below. 

[...***...] 
 Figure 4: Workflow for key
IND-enabling activities of Development Candidate (timing: [12] months) 
 [...***...] 

[...***...] 
 [...***...]


  

			
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 [...***...] 

  

			
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 APPENDIX 8-A 
 R&D PLAN UPDATES 
 [Attached] 







 APPENDIX 8-A 
 R&D PLAN UPDATES 
 R&D Plan for miR-21 in Fibrosis

 [...***...] 

  
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 R&D Plan for miR-21 [...***...] in Hepatocellular Carcinoma (HCC)

 Introduction 
 Extensive
discussions have occurred between Sanofi and Regulus with regards to [...***...] – miR-21 [...***...]. [...***...] will now be part of the ongoing R&D collaboration between Sanofi and Regulus and will require additional
studies in order to achieve the next project milestones. For the miR-21 project the next key milestone is [...***...]. 
 Summary of
key R&D activities for miR-21 
 The key activities for miR-21 project will be as follows. 

[...***...] 
 [...***...] 
 [...***...] 

The aforementioned studies will be planned and executed over the next [...***...] months with the goal to [...***...]. 

  
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 Proposed research plan and resource allocation for miR-21 ONC project up to DC nomination 

 

			
	 Task
	  	 Responsible

		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]


  
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	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]


  
 ***Confidential
Treatment Requested 









			
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]
		
	[...***...]	  	[...***...]


  
 ***Confidential
Treatment Requested 








 [...***...] 

  
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 Summary of key R&D activities for [...***...] 

The attached slide set was prepared during the earlier discussions between Sanofi and Regulus and highlight the rational and justification for
[...***...]. These activities will be executed by Regulus during the next [...***...] months as part of the R&D activities associated with the [...***...]. 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 We believe
that the experiment plan we have put in place addresses all those requirements and we are projecting a target selection decision [...***...]. 
 Proposed validation plan for [...***...] 
 [...***...] 

[...***...] 

[...***...] 
 [...***...] 
 [...***...] 

 

																	
		 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]


  
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		 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]
	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]
	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]

 [...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...]


  
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 [...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...]

 [...***...] 

  
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 APPENDIX 9 
 Regulus Detailed Allocation of Upfront Payments 
 Mir-21 Program 

Allocation of the $[...***...] payment pursuant to Section 6.1 related to Regulus’ Mir-21 Program: 

 

									
	 Intellectual Property
	  	Percentage	 	 	Amount	 
	 [...***...]
	  	 	[...***...	] 	 	 	[...***...	] 
	 [...***...]
	  	 	[...***...	] 	 	 	[...***...	] 
	 [...***...]
	  	 	[...***...	] 	 	 	[...***...	] 
	 [...***...]
	  	 	[...***...	] 	 	 	[...***...	] 

 Other Programs 
 Allocation of the $[...***...] payment pursuant to Section 6.1 related to Other Programs: 
  

									
	 Intellectual Property
	  	Percentage	 	 	Amount	 
	 [...***...]
	  	 	[...***...	] 	 	 	[...***...	] 
	 [...***...]
	  	 	[...***...	] 	 	 	[...***...	] 
	 [...***...]
	  	 	[...***...	] 	 	 	[...***...	] 
	 [...***...]
	  	 	[...***...	] 	 	 	[...***...	] 


  
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	 [...***...]
	  				 			
	 [...***...]
	  	 	[...***...	] 	 	 	[...***...	] 


  
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