UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

March 4, 2015 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

Office of Pesticide Programs 

Registration Division (7505P) 

MEMORANDUM DER for acute toxicity studies for 1 00-RUA T 

Subject: Name of the Product Bicyclopyrone 

EPA File Symbol: 100-RUAT 

DP Barcode 410408 

Decision No 470867 

Action Code: ROlO 

From: 

PC Code: 018986 

CITAB 

Princess Campbell, DVM, MS, DACVPM ~~ \ 

~ 

Through: ·II.. John Redden, M.S. ~ C \ 

CITAB 

Registration Division (7505P) 

To: Grant Rowland/Kathryn Montague RM 23 

Herbicide Branch 

Registration Division (7505P) 

Applicant: Syngenta Crop Protection, LLC. 

Greensboro, NC 27419 

FORMULATION FROM LABEL: 

Active lngredient(s): 

Bicyclopyrone 

Other lngredient(s): 

Total: 

%by wt. 

99.3 

___];!_ 

100.0 
Bicyclopyrone 

Reviewer: Princess Campbell, DVM 

BACKGROUND: 

Syngenta Crop Protection, LLC has submitted a set of six acute toxicity studies to support the 

registration of Bicyclopyrone, an herbicide. The toxicity studies were performed by RCC Ltd, 

w_olferstrasse 4, Switzerland, and Safepharm between 2007 and 2008 (MRIDs 47841966-71 ). 

Deficiencies: All studies are in compliance with EPA guidelines; any deficiency is not 

significant and does not affect the outcome of the study. 

FINDINGS: 

All six studies have been classified as acceptable. 

The toxicology profile is as follows: 

Acute oral toxicity IV acceptable 

Acute dermal toxicity IV acceptable 

Acute inhalation IV acceptable 

Primary eye irritation IV acceptable 

Primary dermal irritation IV acceptable 

Dermal sensitization -ve acceptable 

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MRID 4 7841966 

MRID 47841967 

MRID 47841968 

MRlD 47841970 

MRID 47841969 

MRID 47841971 
Bicyclopyrone 

Reviewer: Princess Campbell, DVM 

LABEL: 

PRODUCT ID #: 000100-01467 

PRODUCT NAME: Bicyclopyrone Technical 

PRECAUTIONARY STATEMENTS 

SIGNAL WORD: CAUTION 

Hazards to Humans and Domestic Animals: 

Wear: Long-sleeved shirt and long pants, Socks, Shoes, and gloves. 

First Aid: No statements are required. Category III statements may be used. 

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Bicyclopyrone 

Reviewer: Prin cess Campbell, DVM 

**DER ~ or F"1e l S 1ym b o I 100 -RUAT 

I. DP BARCODE: 410408 

2. PC CODE: 0 18986 

3. CURRENT DATE: February_ 4, 20 15 

4. TEST ARTICLE: NOA449280; Batch#: SEZ3AP006/MILLED; Solid beige powder; 

Study/Species/Lab MRID Results Tox Core 

Study #/Date Cat Grade 

Acute oral toxicity I rat 47841966 LDso females is > 5000 mg/kg mg/ kg IV A 

RCC Ltd /835493/07-05-2007 

OCSPP 870.1100; OECD 425 

Acute dermal toxicity /rat 47841967 Dermal LDso Males/females > 5000 TV A 

I RCC Ltd /835504107-17-2007 mglkg bw 

OCSPP 870.1200; OECD 402 

Acute inhalation toxicity J rat 47841968 LCso Males and females > 5.210 mg/L IV A 

RCC Ltd 1845145/05-08-2008 MMAD= 3.10 1-1m 

OCSPP 870.1300; OECD 403 GSD = 3.22 

All survived exposure (nose only). 

Primary Skin irritation I rabbit 47841969 Non irritating IV A 

RCC Ltd /835515105-11-2007 

OCSPP 870.2400; OECD 404 

Primary eye irritation I rabbit 47841970 Non irritating IV A 

RCC Ltd /835526107-03-2007 

OCSPP 870.2500; OECD 405 

Dermal sensitization I mouse LLNA- 47841971 Negative. -- A 

Safepharm Laboratories Ltd Positive control (15% HCA): 

/236410053/01-08-2008 

OCSPP 870.2600 

Core Grade Key: A =Acceptable, S = Supplementary, U = Unacceptable, D = Data Gap 

**Detailed DER completed for acute toxicity studies (6 pack) in Global Joint Review format. 

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