Exhibit 10.29


[NitroMed Letterhead]


January
10, 2006


Mr. Gerald Bruce

3465 Byron Drive

Doylestown, PA  18901


Dear
Gerald:


I
am very pleased to formally offer you the position of Vice President of Sales
for NitroMed Inc. reporting to Mark Pavao, Vice President of Sales and
Marketing for NitroMed Inc.  In this
position you will be responsible broadly for developing and driving sales
strategy and results through leadership of a world class sales team.  You will also be a responsible for providing
positive and influential leadership and counsel internally as part of the
NitroMed Inc. senior management team as well as externally with key
stakeholders as appropriate.


The
terms of this offer are as follows:


Annual Base Salary


$220,000
per year paid in 24 equal payments to be reviewed annually.


Annual
Performance Bonus


You
will be entitled to a bonus target of 50% of your annual salary in accordance
with achievement of goals and objectives. 
The size of the bonus program will be based on the overall NitroMed
performance against its major objectives. 
Individual awards will be granted from this bonus pool dependent on
individual achievement.  You will be
guaranteed a minimum of a $90,000 annual bonus for the performance years 2006,
2007 and 2008 to be paid out respectively in 2007, 2008 and 2009.


Annual Performance Stock Options


You
will be eligible to receive an annual stock option grant.  The amount of options available will be
determined by the Board of Directors based on overall company performance.  Individual awards will be granted from this
option pool dependent on individual achievement.


Cost of Living Adjustment


You
will receive a monthly payment of $2,500 for 36 months beginning with your
first month of employment.  These
payments are designed to help with your cost of living transition in
conjunction with your move to the Boston area.


Sign On Cash


You
will receive a one time payment of $45,000 as a sign on bonus to be paid within
your first 30 days of employment with NitroMed Inc.


Sign On Stock Options


You
will be offered an option to purchase 40,000 shares of common stock in the
Company.  The price at which the stock
closes on your start date will be the exercise price of these options.  These 











options
will vest over four years in equal installments as long as you remain in the
employ of the Company.


Group Benefits:


You
will receive comprehensive group health, long term disability, accident and
life insurance benefits and eligibility to participate in NitroMed’s 401K plan.


Leave:


You
will be entitled to illness and vacation days consistent with the Company’s
standard policy.  This policy will
provide you with four weeks of vacation per calendar year.


Relocation


Subject
to your continued employment, the Company will reimburse you up to a sum not to
exceed $75,000 for relocation related expenses including such things as moving
household contents, buying and selling commissions and temporary housing.  Pursuant to your conversation with Michael
Loberg, CEO, in the event there is a reasonable situation in which additional
funds are needed for a specific aspect of relocation, the request should be
made in writing and will be reviewed and subject to his approval.


Change of Control


A
separate change of control agreement will be provided to you that includes
details relative to key definitions, terms and benefits which will include the
following benefit:  you will be entitled
to 2.0 times your salary if the Company or the employee (you) terminates
employment within 12 months of a change of control event.  The Company is in process of finalizing and
establishing these agreements with the entire NitroMed management team as this
offer is being executed and as such will provide it to you shortly.


Agreements:


As
a condition of employment, you will be required to sign the Company’s Invention
and Non-disclosure Agreement and Code of Business Conduct and Ethics.


The
commencement date for this position is February 6, 2006.  Please sign a copy of this letter and return
it as acceptance of this offer by January 16, 2006.


Gerald,
we look forward to working with you at NitroMed.  It is my wish that this position allows you
to participate in the success of NitroMed and will both enrich and enhance your
career experience.


Sincerely,


	
  /s/ Mark Pavao

  	
   

  
	
  Mark Pavao

  
	
  Vice President,
  Marketing and Sales

  



 















 


April
24, 2006


 


Mr. Gerald Bruce

3465 Byron Drive

Doylestown, PA  18901


Re:
Offer Letter Addendum


 


Dear
Gerald:


In
addition to the previously executed offer letter, you will be a participant in
the NitroMed Inc. Executive Severance Benefit Pan and Summary Plan
Description.  All terms and conditions
apply.


This addendum constitutes an exception for you
to Schedule A of the above referenced plan in that you will be entitled to
salary continuation for a period of twelve (12) months in addition to the
following: one times (1X) the average of your last 2 annual bonus amounts or 1X
your existing bonus target or 1X your existing bonus guarantee whichever of the
3 is higher.  You will also be entitled
to 1X any cost of living payments existing at the time of Severance.


	
  Sincerely,

  	
   

  
	
   

  	
   

  
	
  /s/ Argeris Karabelas

  	
   

  	 

	
  Argeris Karabelas

  	
   

  	 

	
  Acting Chief Executive Officer and Chairman