|    |                                                                                                                                                                                                                                                                                                                                             |
|----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| A. | Ginkgo and Cronos are parties to that certain Collaboration and License Agreement dated September l, 2018 (the “Original Agreement”), pursuant to which, among other things, Ginkgo and Cronos agreed to jointly research and collaborate to Develop Collaboration Strains to Scale Up and Manufacture Target Cannabinoids; and |
|    |                                                                                                                                                                                                                                                                                                                                                                                                                                                |
|----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| B. | the Parties desire to amend certain terms of the Original Agreement such that Ginkgo takes on greater responsibility for: 1) additional Development activities prior to Scale Up of a Cronos Product, including lab-scale fermentation and downstream process development activities related to activities necessary to produce and recover a Crones Product from a fermentation process; 2) enabling Scale Up; and 3) enabling Manufacturing. |
|    |                                                                                                                                  |
|----|----------------------------------------------------------------------------------------------------------------------------------|
| 1. | Definitions. Capitalized terms not defined in this First Amendment have the meanings given such terms in the Original Agreement. |
|    |             |
|----|-------------|
| 2. | Amendments. |
|     |                                                                                                                                      |
|-----|--------------------------------------------------------------------------------------------------------------------------------------|
| (a) | Article 1 of the Original Agreement is hereby amended by inserting a new Section 1.138, Section 1.139, and Section 1.140 as follows: |
|       |                                                                            |
|-------|----------------------------------------------------------------------------|
| 1.138 | “Audit” has the meaning ascribed to such term in Section 2.15. |
|       |                                                                                   |
|-------|-----------------------------------------------------------------------------------|
| 1.139 | “Audit Report” has the meaning ascribed to such term in Section 2.15. |
|       |                                                                                       |
|-------|---------------------------------------------------------------------------------------|
| 1.140 | “Fully Burdened Cost” has the meaning ascribed to such term in Exhibit B. |
|       |                                                                                  |
|-------|----------------------------------------------------------------------------------|
| 1.141 | “Transfer Price” has the meaning ascribed to such term in Exhibit B. |
|       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
|-------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 1.142 | “Work Order” means a description of services and additional relevant details mutually agreed upon in a document executed by each of the Parties, pursuant to which Ginkgo will, subject to and pursuant to this Agreement (including Section 2.15), itself or, subject to Section 2.11, through one or more Affiliates or Third Parties, perform a set of services defined therein related to the Development (beyond or modifying the work described in a separate, fully executed TDP), Scale Up or Manufacture, including the facilitation thereof which may involve the establishment of a facility and related operations for such Development, Scale Up or Manufacture, of one or more Cronos Products from a Collaboration Strain. Each Work Order executed by the Parties shall be deemed to be incorporated by reference in this Agreement. The first Work Order is included herein as Exhibit C and shall be deemed approved upon execution of the First Amendment. |
|     |                                                                                                                |
|-----|----------------------------------------------------------------------------------------------------------------|
| (b) | Section 2.3(b) of the Original Agreement is hereby amended and restated in its entirety to be read as follows: |

----

|     |                                                                                                                |
|-----|----------------------------------------------------------------------------------------------------------------|
| (c) | Section 2.4(b) of the Original Agreement is hereby amended and restated in its entirety to be read as follows: |
|     |                                                                                                                                                                                                                                   |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (d) | The scope of the Scale Up Transfer in Section 2.8(b) of the Original Agreement and the Manufacture Transfer in Section 2.8(c) of the Original Agreement may be modified and qualified by the content of an applicable Work Order. |
|     |                                                                                                |
|-----|------------------------------------------------------------------------------------------------|
| (e) | Article 2 of the Original Agreement is hereby amended by adding a new Section 2.15 as follows: |
|     |                                                                                                |
|-----|------------------------------------------------------------------------------------------------|
| (f) | Article 2 of the Original Agreement is hereby amended by adding a new Section 2.16 as follows: |
|     |                                                                                                             |
|-----|-------------------------------------------------------------------------------------------------------------|
| (g) | Section 4.3 of the Original Agreement is hereby amended and restated in its entirety to be read as follows: |
|     |                                                                                               |
|-----|-----------------------------------------------------------------------------------------------|
| (h) | Article 5 of the Original Agreement is hereby amended by adding a new Section 5.8 as follows: |
|     |                                                                                                                                                                                                                                                                         |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (a) | Transfer Price. As consideration for any work performed under a Work Order, Cronos hereby agrees to pay to Ginkgo the amount equal to the Transfer Price of all such activities performed under such Work Order, as set forth in an invoice pursuant to Section 5.8(b). |
|     |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (b) | Invoicing & Reconciliation. As more specifically set forth in Exhibit B, following the end of each calendar month during the Term in which there is an active Work Order, Ginkgo will submit to Cronos an invoice setting forth the Transfer Price to be paid based on the services provided during such calendar month in connection with any active Work Order. Invoices will be submitted electronically to Cronos at Accounts Payable (ap.thecronosgroup.com). Payment of all amounts owed by Cronos pursuant to this Section 5.8 will be remitted to Ginkgo on or before forty­ five (45) days from the date the invoice therefor is received by Cronos. The foregoing will not limit Ginkgo's right |

----

----

----

----