EXHIBIT
      10.1

    


    AMENDMENT
      NO. 2 TO LEASE

    


    


    AGREEMENT
      made this 28th
      day of
      February, 2007, between 100/200 FOXBOROUGH BOULEVARD REALTY TRUST, with its
      principal address c/o CB Richard Ellis-N E Partners, 380 Westminster Street,
      Providence, Rhode Island, 02903, hereinafter referred to as Lessor, and
      Cyberkinetics, Inc., hereinafter referred to as Lessee.

     

    WITNESSETH

    


    That
      the
      Lease dated May 9, 2003 (the “Original Lease”), covering certain square feet of
      rentable floor space at Building Number 100 (Building 100) in the Foxborough
      Business Center located at 100 Foxborough Boulevard (the original space),
      Foxborough, Massachusetts, for a term commencing June 1, 2007, and expiring
      May
      31, 2008 between the Lessee and the Trustees of CC&F Foxborough Trust, Whose
      interest is now vested in the Lessor herein, is hereby amended as
      follows:

    


    
      	
              TERM:

            	
              Effective
                June 1, 2007 through May 31, 2008.

            
	 	 
	
              PREMISES
                AREA: 

            	
              Approximately
                7,769 square feet of Rentable Area

            
	 	 
	
              PROPORTIONATE
                

            	 
	
              SHARE: 

            	
              `11.95%

            
	 	 
	
              BASE
                RENT:

            	
              6/1/07-
                5/31/08 (7,769 sf @ $19.00 psf) $12,300.92 per month $147,611.00
                per Year.

            
	 	
               

            
	
              BASE
                YEAR &

            	 
	
              BASE
                TAXES:

            	
              2007
                actual

            
	 	 
	
              ELECTRICITY:

            	
              As
                the building has one electric meter, the Tenant will pay $1.25 psf
                for its
                use of electricity for lights and plugs. ($809.27 per
                month)

            
	 	 
	
              LANDLORD’S

            	 
	
              WORK:

            	
              None

            
	 	 
	
              SPACE
                IMPROVEMENT:

            	
              The
                Tenant will have the option to make modest space improvements at
                Tenant’s
                election and sole cost subject to Landlord approval.

            
	 	 
	
              RIGHT
                TO RENEW:

            	
              Tenant
                will have the option to renew for one (1) five (5) year period at
                fair
                market value with a 180 day prior written notice to
                Landlord.

            


    

    


    Except
      as
      heretofore and hereby amended said Lease Agreement dated February 2003, is
      in
      all respects ratified and confirmed.

    


    IN
      WITNESS WHEREOF, the Lessor has signed and sealed this instrument this
      28th
      day of
      February, 2007, and the Lessee has signed and sealed this instrument on the
      28th
      day of
      February, 2007.

    


    
      	
              In
                the presence of:

            	 	
              LANDLORD:

            
	 	 	 	 
	
               

            	 	
              By:
                

            	
              /s/
                Charles E. Harlfinger, Trustee

            
	 	 	
              Charles
                E. Harlfinger, Trustee

            
	 	 	
              and
                not individually

            
	
               

            	 	 	 
	 	 	 	 
	 	 	 	 
	
              In
                the presence of:

            	 	
              TENANT:

            
	 	 	
              Cyberkinetics,
                Inc.

            
	
               

            	 	 	 
	 	 	
              By:

            	
               /s/
                Timothy R. Surgenor

            
	
               

            	 	
              Name:
                Timothy R. Surgenor

            
	
               

            	 	
              Title:
                President & CEO