### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460

March 4, 2015 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION 

### Office of Pesticide Programs Registration Division (7505P)

MEMORANDUM DER for acute toxicity studies for 1 00-RUAT Subject: Name of the Product Bicyclopyrone EPA File Symbol: 100-RUA T DP Barcode 410408 Decision No 470867 Action Code: ROlO
From: PC Code: 018986 

### Princess Campbell , DVM, MS , DACVPM



# ~~ **~** CITAB \ Through: 

### · II.. John Redden, M.S.

**~** C \ 

### CITAB Registration Division (7505P) To : Grant Rowland / Kathryn Montague RM 23 Herbicide Branch Registration Division (7505P) Applicant: Syngenta Crop Protection , LLC. Greensboro , NC 27419
FORMULATION FROM LABEL: Active lngredient(s): Bicyclopyrone Other lngredient(s): Total: %by wt. 

### 99.3 ___];!_ 

### 100.0Bicyc lopyrone Reviewer: Princess Campbell, DVM
BAC K GROUN D: Syngenta Crop Protection, LL C has submitted a set of six acute toxi city stu di es t o support the registration of Bic yclop yro ne , an herbicide . T he toxicity st udi es were p e rformed by RCC Ltd , w_o lferstrasse 4, Switzerland , and Safepharm between 2007 and 2008 (MRIDs 47841966 -71 ). Defici e nc ies: All s tudi es are in co mplianc e w ith EPA guidelines; any d eficiency i s not signifi cant and does n ot affect the outcome of the study
.
FINDINGS: A ll s i x s tudie s have be en class i fied as acc ep table. The to xicology pro fil e is as follows :
Ac ute oral t ox ici ty IV acce ptab l e Acute d erm al toxicity IV accep tab l e Ac ute inhalation IV accep tabl e Primary eye irrita tion IV acceptab l e Primary d ermal irritation IV acceptab le Dermal se n s iti zation

- ve acceptable

2 MRID 4 78 41966 MRID 47841967 M RID 47841968 MRlD 47841970 MRID 47841969 MRID 4784197 1Bicyclopyrone Reviewer: Princess Campbell, DVM

LABEL:
PRODUCT ID #: 000100-01467 PRODUCT NAME: Bicyclopyrone Technical PRECAUTIONARY STATEMENTS SIGNAL WORD: CAUTION Hazards to Humans and Domestic Animals: Wear: Long-sleeved shirt and long pants, Socks, Shoes, and gloves. First Aid: No statements are required

. Category III statements may be used.

3Bicyclopyrone Reviewer: Pri n cess Campbell, DVM

**DER

**~** F" l S b I 100 RUAT or 1e 1ym o 

## - I. DP BARCODE: 410408 2. PC CODE : 0 18986 3. CURRENT DATE : February

_ 4 , 20 15 4. TEST ARTICLE : NOA449280 ; Batch#: SEZ3AP006/MILLED ; Solid beige powder; Study /Species/Lab MRID Resu l ts Tox Core Study #/Date Cat Grade Acute oral toxicity I rat 47841966 LDso females is > 5000 mg/kg mg/ kg 

### I V A RC C Ltd /835493/ 07-05-2007 OCSPP 870.1100 ; OECD 425

Acute dermal toxicity / rat 4784 1967 Dermal LDso Males/females > 5000 

### TV A I RC C Ltd /835504 1 07-17-2007 mglkg bw OCSPP 870.1200 ; OECD 402 Acute inhalation toxicity J rat 47841968 LC so Mal es and female s > 5.210 m g/L 

### I V A RC C Ltd 1845145/ 05-08-2008 MMAD = 3.10 1-1m OCSPP 870.1300 ; OECD 403 GSD = 3.22 All s urvive d exposure (nose only). Primary Skin irritation I rabbit 47841969 Non irritating 

### IV A RCC Ltd / 835515 105- 11-2007 OCSPP 870.2400 ; OECD 404 Pr

imary eye irritat ion I rabbit 4784 1970 Non irritating 

### IV A RCC Ltd /835526 1 07-03-2007 OCSPP 870.2500 ; OEC D 405 Dermal sens it ization I mouse LLNA- 47841971 Negative

. 

### -- A Safepharm Laboratories Ltd Po s itive control ( 15 % HCA): /23 64 1 0053/ 01-08-2008 OCSPP 870.2600 Core Grade Key : A = Acceptable , S = Supplementary , U = Unacceptable, D = Data Gap **Detailed DER completed for acute toxicity studies (6 pack ) in Global Joint Rev iew format.

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