Exhibit 4.6 SUBSCRIPTION
AGREEMENT THIS
SUBSCRIPTION AGREEMENT (this Agreement), dated as of June 17, 2005, by and
among MILESTONE SCIENTIFIC INC., a Delaware corporation (the Company), and the
subscriber identified on the signature page hereto (the Subscriber). WHEREAS,
the Company and the Subscriber are executing and delivering this Agreement in reliance
upon an exemption from securities registration afforded by the provisions of Section 4(2)
and Rule 506 of Regulation D (Regulation D) as promulgated by the United
States Securities and Exchange Commission (the Commission) under the
Securities Act of 1933, as amended (the 1933 Act); and WHEREAS,
the parties desire that, upon the terms and subject to the conditions contained herein,
the Company shall issue and sell to the Subscriber, as provided herein, and the Subscriber
shall purchase, 20,000 Units, each Unit consisting of (i) ten (10) shares of the
Companys common stock, $.001 par value (the Common Stock), and
(ii)  two warrants each to purchase one share of Common Stock (the
Warrants), in the form attached hereto as Exhibit A (the
Warrants). The shares underlying the Warrants are referred to as the Warrant
Shares. The per Unit Purchase Price shall be $24.94, which is equal to the average closing
price of the Common Stock on the American Stock Exchange during the ten trading days
ending on June 16, 2005, multiplied by 10. The aggregate Purchase Price shall be payable
to the Company on the Closing Date, as defined in Section 10 hereof. The shares of Common
Stock issuable to the Subscriber are referred to herein as the Shares, and the
Shares, the Warrants and the Warrant Shares are collectively referred to herein as the
Securities. NOW,
THEREFORE, in consideration of the mutual covenants and other agreements contained in
this Agreement the Company and the Subscriber hereby agree as follows: 1.
Purchase and Sale of Shares and Warrants. Subject to the satisfaction (or waiver)
of the conditions to Closing set forth in this Agreement, the Subscriber shall purchase
the Shares and Warrants for the Purchase Price indicated on the signature page hereto,
and the Company shall sell the Shares and Warrants called for by the above price to the
Subscriber. The Purchase Price for the Shares and Warrants shall be paid in cash. The
Company shall (i) instruct its transfer agent to issue stock certificates for the number
of Shares included in the Units to be purchased hereunder and to deliver such Shares to
the Subscriber within 15 business days of the Closing Date, such Shares to be registered
in the name of the Subscriber and (ii) deliver Warrants for the number of Warrants
purchased hereunder to the Subscriber within said 15 business days. The Company will not
issue fractional Units but will refund amounts in excess of the price of the nearest full
number of Units which can be purchased with the purchase price tendered hereunder. 2.
Warrants. Promptly after the Closing Date the Company will issue two Warrants to
the Subscriber for each ten (10) shares issued to such Subscriber on the Closing Date.
The per Warrant exercise price shall be $4.89 per share. The Warrants shall be
exercisable    until February 16, 2009.


3.
Subscribers Representations and Warranties. The Subscriber hereby
represents and warrants to and agrees with the Company that:


(a)
Information on Company. The Subscriber has been furnished with or has had access
at the EDGAR Website of the Commission to the Companys Form 10-KSB for the year
ended December 31, 2004 and the Companys Form 10-KSB for the year ended December
31, 2003 as filed with the Commission, together with all subsequently filed Forms 10-QSB,
8-K, and filings made with the Commission available at the EDGAR website (hereinafter
referred to collectively as the Reports). The Subscriber has considered all
factors the Subscriber deems material in deciding on the advisability of investing in the
Securities.


(b)
Information on Subscriber. At the time the Subscriber was offered the Securities
it was, and as of the date hereof it is an accredited investor, as such term
is defined in Regulation D promulgated by the Commission under the 1933 Act, is
experienced in investments and business matters, has made investments of a speculative
nature and has purchased securities of United States publicly-owned companies in private
placements in the past and, with its representatives, has such knowledge and experience
in financial, tax and other business matters as to enable the Subscriber to utilize the
information made available by the Company to evaluate the merits and risks of and to make
an informed investment decision with respect to the proposed purchase, which represents a
speculative investment. The Subscriber has the authority to purchase and own the
Securities. The Subscriber is able to bear the economic risk of such investment and at
the present time, is able to afford a complete loss thereof. The information set forth on
the signature page hereto regarding the Subscriber is accurate.


(c)
Purchase of Common Stock and Warrants. The Subscriber is purchasing the Common
Stock and Warrants as principal for its own account and not with a view to any
distribution thereof (this representation and warranty not limiting such Subscribers
right to sell the Shares and Warrant Shares pursuant to the Registration Statement (as
defined below hereof) or otherwise in compliance with applicable federal and state
securities laws).


(d)
Compliance with 1933 Act. The Subscriber understands and agrees that the
Securities have not been registered under the 1933 Act or any applicable state securities
laws, by reason of their issuance in a transaction that does not require registration
under the 1933 Act (based in part on the accuracy of the representations and warranties
of Subscriber contained herein), and that such Securities must be held indefinitely
unless a subsequent disposition is registered under the 1933 Act or any applicable state
securities laws or is exempt from such registration.


(e)
Current Holdings. The Subscriber is currently a holder of [          ] shares of the
Companys Common Stock.


(f)
Correctness of Representations. The Subscriber represents that the foregoing
representations and warranties are true and correct as of the date hereof in all material



respects and, unless the Subscriber
otherwise notifies the Company prior to the Closing Date (as hereinafter defined), shall
be true and correct in all material respects as of the Closing Date.


4.
Company Representations and Warranties. The Company represents and warrants to
and agrees with the Subscriber that (i)the Company is duly organized, validly
existing and in good standing on the date hereof, (ii) has full power and authority to
issue the Securities, (iii) is eligible to register the resale of its Common Stock by the
Subscriber under Form S-3 promulgated under the 1933 Act, (iv) upon receipt and
acceptance of consideration from the Subscriber the Securities will be legally and
validly issued, (v) the Companys Form 10-KSB for the year ended December 31, 2004,
fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange
Act of 1934, as amended and the information contained in the Form 10-KSB fairly presents,
in all material respects, the financial condition and results of operations of the
Company and does not contain any untrue statement of a material fact or omit to state a
material fact required to be stated therein or necessary to make the statements therein
not misleading and (vi) the Company has taken all action required by its Articles of
Incorporation and Bylaws and the rules and regulations of the American Stock
Exchange to approve the offer and sale of the securities, except that it has not applied
for additional listing of such securities with the American Stock Exchange but
undertakes to do so promptly upon closing hereunder.


5.
Regulation D Offering. The offer and issuance of the Securities to the Subscriber
is being made pursuant to the exemption from the registration provisions of the 1933 Act
afforded by Section 4(2) of the 1933 Act and Rule 506 of Regulation D promulgated
thereunder.


6.
Registration and Listing.


(a)
The Company covenants and agrees with the Subscriber that on or before the 70th
day after the Closing Date, prior to the Filing Date the Company shall prepare and file
with the Commission a Registration Statement covering the shares of common stock issuable
under this Agreement and issuable upon exercise of the Warrants (the Registrable
Securities) for an offering to be made on a continuous basis pursuant to Rule 415.
The Registration Statement shall be on Form S-3. The Company shall cause the Registration
Statement to become effective and remain effective as provided herein. The Company shall
use its best efforts to cause the Registration Statement to be declared effective under
the Securities Act as promptly as possible after the filing thereof. The Company shall
use its best efforts to keep the Registration Statement continuously effective under the
Securities Act until the date which is the earlier date of when (i) all Registrable
Securities have been sold or (ii) all Registrable Securities may be sold immediately
without registration under the Securities Act and without volume restrictions pursuant to
Rule 144(k), as determined by the counsel to the Company pursuant to a written opinion
letter to such effect, addressed and acceptable to the Companys transfer agent and
the affected Holders .


(b)
Transfers. The Securities may only be disposed of in compliance with state and
federal securities laws. In connection with any transfer of Securities other than
pursuant to an effective registration statement, to the Company, to an Affiliate of a
Subscriber or



in connection with a pledge as
contemplated in this Section 10, the Company may require the transferor thereof to
provide to the Company an opinion of counsel selected by the transferor, the form and
substance of which opinion shall be reasonably satisfactory to the Company, to the effect
that such transfer does not require registration of such transferred Securities under the
1933 Act. As a condition of transfer, any such transferee shall agree in writing to be
bound by the terms of this Agreement and shall have the rights of the Subscriber under
this Agreement and the Registration Rights Agreement.


(c)
Shares Legend. The Subscriber agrees to the imprinting, so long as is required by
this Section 7(b), of a legend on the Shares and the Warrant Shares, in substantially the
following form:


THE
SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED. THESE SHARES MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR
HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER SUCH SECURITIES
ACT OR ANY APPLICABLE STATE SECURITIES LAW OR AN OPINION OF COUNSEL REASONABLY
SATISFACTORY TO COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED, EXCEPT THAT THESE
SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OF THE HOLDER WITH
A REGISTERED BROKER-DEALER OR OTHER LOAN OF THE HOLDER WITH A FINANCIAL INSTITUTION THAT
IS AN ACCREDITED INVESTOR AS DEFINED IN RULE 501(a) UNDER THE SECURITIES
ACT.(d)
Warrant Legend. The Subscriber agrees to the imprinting, so long as is required
by this Section 6, of a legend on the Warrants, in substantially the following form:


THIS
WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE NOT
BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. THIS WARRANT AND THE SHARES
OF COMMON STOCK ISSUABLE UPON EXERCISE OF THIS WARRANT MAY NOT BE SOLD, OFFERED FOR SALE,
PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THIS
WARRANT UNDER SAID ACT OR ANY APPLICABLE STATE SECURITIES LAW OR AN OPINION OF COUNSEL
REASONABLY SATISFACTORY TO COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED, EXCEPT THAT
THESE SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OF THE
HOLDER
WITH
A REGISTERED BROKER-DEALER OR OTHER LOAN OF THE HOLDER WITH A FINANCIAL INSTITUTION THAT
IS AN ACCREDITED INVESTOR AS DEFINED IN RULE 501(a) UNDER THE SECURITIES ACT(e)
Certificates. Certificates evidencing the Shares and Warrant Shares shall
not contain any legend (including the legend set forth in Sections 7(b) and (c)), (i)
while a registration statement (including the Registration Statement) covering the resale
of such security is effective under the 1933 Act, or (ii) following any sale of such
Shares or Warrant Shares pursuant to Rule 144, or (iii) if such Shares or Warrant Shares
are eligible for sale under Rule 144(k), or (iv) if such legend is not required under
applicable requirements of the 1933 Act (including judicial interpretations and
pronouncements issued by the Staff of the Commission). The Company shall cause its
counsel to issue a legal opinion to the Companys transfer agent promptly after the
effective date of the Registration Statement if required by the Companys transfer
agent to effect the removal of the legend hereunder as and when any Subscriber so
requests. If all or any portion of a Warrant is exercised at a time when there is an
effective registration statement to cover the resale of the Warrant Shares, such Warrant
Shares shall be issued free of all legends


(f)
Acknowledgement. The Subscriber agrees that the removal of the restrictive
legend from certificates representing Securities as set forth in this Section 7 is
predicated upon the Companys reliance that the Subscriber will sell any Securities
pursuant to either the registration requirements of the 1933 Act, including any
applicable prospectus delivery requirements, or an exemption therefrom.


(g)
       The Company  covenants  and agrees with the  Subscriber  that on or before the
40th day after the Closing Date it will file an application with the American Stock
Exchange to list the shares of the Companys Common Stock underlying the Units,
including the shares of Common Stock underlying the Warrants and will use its best
efforts to prosecute such application to effectiveness.


7.
Conditions Precedent to Obligations of the Company. The obligations of the
Company are subject to the fulfillment prior to or on the Closing Date of the following
conditions any of which may be waived by the Company in writing:


(a)
all representations and warranties of the Subscriber contained in this Agreement shall be
true and correct in all respects as of the Closing Date with the same effect as though
such representations and warranties had been made on or as of such date; and


(b)
all agreements and covenants of the Subscriber to be performed or complied with on or
prior to the Closing Date have in all material respects been so performed or complied
with.


8.
Conditions Precedent to Obligations of the Subscriber. The obligations of the
Subscriber are subject to the fulfillment prior to or on the Closing Date of the
following conditions any of which may be waived by the Subscriber in writing:



(a)
all representations and warranties of the Company contained in this Agreement shall be
true and correct in all respects as of the Closing Date with the same effect as though
such representations and warranties had been made on or as of such date; and


(b)
all obligations, agreements and covenants of the Company to be performed or complied with
on or prior to the Closing Date shall have, in all respects been so performed or complied
with.


9.
Miscellaneous.


(a)
Notices. All notices, demands, requests, consents, approvals, and other
communications required or permitted hereunder shall be in writing and, unless otherwise
specified herein, shall be (i) personally served, (ii) deposited in the mail, registered
or certified, return receipt requested, postage prepaid, (iii) delivered by reputable air
courier service with charges prepaid, or (iv) transmitted by hand delivery, telegram, or
facsimile, addressed as set forth below or to such other address as such party shall have
specified most recently by written notice. Any notice or other communication required or
permitted to be given hereunder shall be deemed effective (a) upon hand delivery or
delivery by facsimile, with accurate confirmation generated by the transmitting facsimile
machine, at the address or number designated below (if delivered on a business day during
normal business hours where such notice is to be received), or the first business day
following such delivery (if delivered other than on a business day during normal business
hours where such notice is to be received) or (b) on the second business day following
the date of mailing by express courier service, fully prepaid, addressed to such address,
or upon actual receipt of such mailing, whichever shall first occur. The addresses for
such communications shall be: (i) if to the Company, to: Milestone Scientific Inc., 230
South Orange Avenue, Livingston, NJ 07039Attention: Leonard Osser, Chairman, fax: (973)
535-2829, with a copy to: Morse, Zelnick, Rose & Lander, LLP, 405 Park Avenue, Suite
1401, New York, New York 10022, Attention: Stephen Zelnick, telecopier: (212) 838-9190,
(ii) if to the Subscriber to: the address and telecopier number indicated on the
signature pages hereto.


(b)
Closing. The consummation of the transactions contemplated herein (the Closing
Date) shall take place at the offices of Morse, Zelnick, Rose & Lander, LLP, upon
receipt of good funds at its escrow account ,


The
Chase Manhattan Bank,1211 Avenue of the Americas,
                               New York, New York 10036,
                               Account Name: Morse, Zelnick, Rose & Lander, LLP
                                         Attorney Trust Account
                               Account Number: 967086639
                               ABA Number: 021000021and upon the satisfaction of all
conditions to Closing set forth in this Agreement.



(c)
Entire Agreement; Assignment. This Agreement and the other Transaction Documents
represent the entire agreement between the parties hereto with respect to the subject
matter hereof and may be amended only by a writing executed by the Company and the
Subscriber. Neither the Company nor the Subscriber has relied on any representations not
contained or referred to in this Agreement and the documents delivered herewith. No right
or obligation of the Company shall be assigned without prior notice to and the written
consent of the Subscriber. The Subscriber may assign any or all of its rights hereunder
to any person in connection with a transfer of any Security to such person, provided such
transferee agrees in writing to be bound, with respect to the transferred Securities, by
the provisions hereof that apply to the Subscriber.


(d)
Counterparts/Execution. This Agreement may be executed in any number of
counterparts and by the different signatories hereto on separate counterparts, each of
which, when so executed, shall be deemed an original, but all such counterparts shall
constitute but one and the same instrument. This Agreement may be executed by facsimile
signature and delivered by facsimile transmission.


(e)
Law Governing this Agreement. This Agreement shall be governed by and construed
in accordance with the laws of the State of New York without regard to principles of
conflicts of laws. Any action brought by either party against the other concerning the
transactions contemplated by this Agreement shall be brought only in the state courts of
New York or in the federal courts located in the state of New York. The parties and
the individuals executing this Agreement and other agreements referred to herein or
delivered in connection herewith on behalf of the Company agree to submit to the
jurisdiction of such courts and waive trial by jury.The prevailing party shall be
entitled to recover from the other party its reasonable attorneys fees and costs.
In the event that any provision of this Agreement or any other agreement delivered in
connection herewith is invalid or unenforceable under any applicable statute or rule of
law, then such provision shall be deemed inoperative to the extent that it may conflict
therewith and shall be deemed modified to conform with such statute or rule of law. Any
such provision which may prove invalid or unenforceable under any law shall not affect
the validity or enforceability of any other provision of any agreement.


(f)
Equitable Adjustment. The Securities and the purchase prices of Securities being
purchased hereunder shall be equitably adjusted to offset the effect of stock splits,
stock dividends, and distributions of property or equity interests of the Company to its
shareholders occurring between the date of this Agreement and the Closing Date.


[THIS SPACE
INTENTIONALLY LEFT BLANK]



SIGNATURE PAGE TO
SUBSCRIPTION AGREEMENT


Please
acknowledge your acceptance of the foregoing Subscription Agreement by signing and
returning a copy to the undersigned whereupon it shall become a binding agreement between
us.

Dated: June _____,
      2005 
      Dated: June _______ 2005
    The Company 
      MILESTONE SCIENTIFIC INC 
      a Delaware corporation 
      By:_________________________________ 
            Name: 
            Title: 
      Subscriber 
      [      ] 
      by:_________________________________ 
            Name: 
            Title:SUBSCRIBERS
      NAME AND
      ADDRESS
    PER
      UNIT
      PURCHASE
      PRICE
    
    NO.
      OF
      UNITS
    
    TOTAL
      
      AGGREGATE
      PURCHASE 
      PRICE$
    24.94Telephone number:


Facsimile number:



EXHIBIT A


[Form
of Warrant]