UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, DC 20460 

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION 

PC Code: 090100 

DP Barcode: 381819,381820,381821 

Date: January 4,20 1 1 

D&us~o~S: 487973,41R971; -7966 

MEMORANDUM 

Subject: Chlorantraniliprole (E2Y45): Ecological Risk Assessment to Support Numerous 

Proposed New Uses 

To: Venus Eagle, Risk Manager 

Kable Davis, Risk Manager Reviewer 

Registration Division (7505~) 

From: Michael B. Lowit, Ph.D., Ecologist 

Christopher M. Koper, Chemist 

Nancy Andrews, Branch Chief 

Environmental Risk Branch I 

Environmental Fate and Effects Division (7507P) 

Office of Pesticide Programs 

This memorandum summarizes the ecological risks associated with numerous proposed uses 

for the insecticide Chlorantraniliprole. The risk assessment considers three products: 

~ltacor~, coraganm, and DPX-E2Y45 625FS. Assessed uses include field corn (seed 

treatment), Brassica leafy vegetables, bulb vegetables (onion, bulb subgroup), cucurbit 

vegetables, fruiting vegetables, leafy vegetables (non-Brassica), okra, peanut, root and tuber 

vegetables (except potato), leaves of root and tuber vegetables, bushberry subgroup, large 

shrubltree subgroup, low growing berry subgroup, tea, and ti palm. 

Foliar applications (ground or aerial spray) are proposed up to 0.065 lb ai/A or 0.099 lb ai/A 

depending on the use. Soil-at-planting methods are proposed for cucurbit, fruiting, and leafy 

vegetables up to 0.098 lb ai/A. The maximum seasonal application rate is 0.2 lb ai/A for all 

proposed uses. A single application of chlorantraniliprole-treated seed (field corn) is 

proposed at up to 0.054 lb ai/A followed by foliar applications not to exceed the seasonal 

maximum of 0.2 lb ai/A (treated seed and foliar combined). 

TEXT SEARCHABLE DOCUMENT - 2011
1. Executive Summary 

chlorantraniliprole is an insecticide belonging to the diarnide class of chemistry. The specific 

mode of action is through chlorantraniliprole binding with insect ryanodine receptors which 

causes muscle contraction and leads to paralysis and ultimately death of the insect. 

Based on the environmental fate review, chlorantraniliprole may be characterized as 

persistent and mobile in terrestrial and aquatic environments. Extended chlorantraniliprole 

use is expected to cause accumulation of residues in soil from year to year. Major routes of 

dissipation are expected to be alkaline-catalyzed hydrolysis, photodegradation in water, 

leaching, and runoff. 

Previous Section 3 assessments for chlorantraniliprole (DP3385 12 and DP361404) identified 

direct risks to freshwater and estuarinelmarine invertebrates. All the aquatic exposure 

estimates for the current assessment fall within the range of exposure estimates from the 

previous two assessments. Because the aquatic toxicity endpoints have not changed since the 

previous assessments, the aquatic risks posed by the proposed new uses fall within the range 

of risk estimates identified in the previous assessments. LOC exceedences are similar for the 

proposed new uses (LOCs were exceeded only for freshwater and estuarinelmarine 

invertebrates). Therefore, this assessment, in accordance with the findings of the previous 

assessments, identified direct risks to freshwater and estuarinelmarine invertebrates and 

indirect risks to organisms that may depend on them for sustenance for all proposed new 

uses (except the bushberry subgroup for estuarinelmarine invertebrates). 

Terrestrial exposures were quantified only for the chlorantraniliprole-treated seed (field corn) 

application. No LOCs were exceeded for non-listed terrestrial plants (risks to listed terrestrial 

plants cannot be precluded due to a non-definitive NOAEC), birds, and mammals in previous 

assessments (DP338512 and DP361404) at single and annual application rates that are equivalent 

to those proposed for the non-seed uses (foliar and soil-at-planting applications) considered in 

this assessment. Therefore, this assessment did not reproduce these calculations. No LOCs are 

expected to be exceeded for birds, mammals, or non-listed terrestrial plants for the proposed nonseed treatment uses. However, potential risks to non-target terrestrial invertebrates is a concern 

considering the proposed application rates, the submitted toxicity data, and the mode of action of 

chlorantraniliprole as an insecticide. Finally, potential risks to listed terrestrial plants cannot be 

precluded. 

Although the proposed application rate for chlorantraniliprole-treated seed (field corn) does not 

exceed previously assessed application rates, T-REX v1.4.1 predicts higher terrestrial exposure 

from the seed treatment than from other uses, which requires risk quantification for terrestrial 

organisms. No terrestrial LOCs were exceeded for the seed application except for acute and 

chronic exposure to birds. 
Table 1. Summary of LOC Exceedences for the Proposed New Uses of Chlorantraniliprole 

on a Number of Crops 

I Potential 

"The available data could not preclude potential risks to listed terrestrial plants. 

LU 

Effect 

Direct Effect (LOC 

I Exceedence) I I I I 1 I I 1 

b~~s were not calculated dueto lack of a standard quantification methodology for non-listed species. Therefore, the 

'LOC exceedance' was based on lines of evidence including application rate, toxicity data, and the mode of action of 

chlorantraniliprole. 

2. Data Gaps 

Taxonomic Group 

-- 1 

No data gaps were identified in the 2007 assessment (D3385 12). However, since the 2007 

assessment was conducted, submission of an acute oral toxicity study in a passerine species was 

included as part of the Part 158 data requirements. In addition, without submission of a study 

that defines a terrestrial plant NOAEC, the presumption of an LOC exceedance for listed plants 

will be made. Studies addressing passerine species and terrestrial plants have been recently 

submitted and are currently under review. 

1 J 141 J Indirect Effect 

3. Uncertainties and Proposed Label Changes 

Birds 

J 

The proposed labels state that the maximum application of chlorantraniliprole is 0.2 lb ai/A per 

crop per season or 0.2 lb ai/A per crop depending on the use. In modeling both the aquatic and 

terrestrial EECs, it is assumed that the registrant intended for one season to be equivalent to one 

year. Therefore, it is assumed that the annual maximum application rate is 0.2 lb ai/A. 

Language should be added to the labels indicating that 0.2 lb ai/A is the annual limit. If the 

labels are intended to allow multiple growing seasons per year, then the calculated EECs may 

under estimate the actual exposure. 

Fish 

-- 

J 

The label does not state how chlorantraniliprole-treated field corn seed should be planted. This 

assessment assumes that the label intends for standard fanning practices and that seed will be 

incorporated into the soil. In addition, a one inch incorporation depth was assumed when 

modeling field corn. Language should be added to the label stating the incorporation depth as 

this parameter will affect environmental exposure. 

Mammals 

-- 

4. Scope of Assessment 

Aquatic 

Invertebrates 

J 

J 

An abbreviated review was conducted by EFED for the following reasons: 

Aquatic 

Plants 

-- 

Terrestrial 

Plants 

-- a 

J 

This assessment uses the same toxicity and fate data that was used in previous 

assessments. Toxicity and fate studies have been recently submitted but are under review 

(MRID 48075301,48075302,48075303,48216601,48216602, and 48216603). 

Proposed application rates, intervals, and seasonal loads are equivalent to or less than 

previously assessed application rates. 

Terrestrial 

Invertebrates 

Jb 
5. Summary of Proposed Uses 

The registrant proposed a number of new uses for chlorantraniliprole (Table 2). Foliar 

applications (ground or aerial spray) are proposed up to 0.065 lb ai/A or 0.099 lb ai/A depending 

on the use. Soil-at-planting methods (in-furrow spray, transplant water treatment, hill drench, 

surface band, and soil shank injection) are proposed for cucurbit, fmiting, and leafy vegetables 

up to 0.098 lb ai/A. The maximum seasonal application rate is 0.2 Ib ai/A for all proposed uses. 

In addition, a single application of chlorantraniliprole-treated seed (field corn) is proposed at up 

to 0.054 lb ai/A followed by foliar applications not to exceed the seasonal maximum of 0.2 lb 

ai/A (treated seed and foliai combined). The proposed application rates are within those 

assessed in 2007 (DP338512) up to 0.5 lb ai/A. Table 2 summarizes the proposed new uses and 

the previously assessed uses from DP3385 12 and DP361404. 

Table 2. Pro~osed and Previouslv Assessed Use Rates for Chlorantranili~role 

Product 

DuPont DPX-E2Y45 

625FS 

DuPont Coragen 

, \, 120 Cotton 0.098 0.2 

use1 

drip chemigation 

Corn, field and pop 

Corn. sweet 

1 Cucurbit vegetables 

foliar 

Forage, fodder, 

Fruiting vegetables 

yoliar, drip 

treatment) 

0.098 2 (5 foliar, 10 drip 0.2 

chemigation) 

Proposed New Use 

Field corn (seed ( 0.054 I 1 for seed, 2 for 1 0.2 ' 

Max Application 

Rate 

(lb ai/A) 

/ foliar (7)' 1 

0.098 

0.065 

0.065 

Max No. of Apps 

(min. interval, 

days) 

Previously Assessed Uses 

2 (10) 

3 (7) 

3 (1) 

Grass forage 

Herbs 

Hops 

Mag Seasonal Rate 

(Ib ai/A) 

0.2 

0.2 

0.2 

legume vegetables 

Mint 

Non-grass animal 

feed 

Okra 

0.2 

0.2 

Artichoke 

Asparagus 

Brassica, leafy 

0.065 

0.065 

0.065 

pp 

0.065 

0.065 

0.065 

vegetables 

foliar 

0.098 

0.065 

3 (7) 

3 (3) 

3 (7) 

Leafy vegetables, 

non-brassica Voliar, 

drip chemigation) 

0.065 1 0.2 

2 (14) 

3 (3) 

0.2 

0.2 

0.2 

2 (3 foliar, 10 drip 

chemigation) 

0.098 

3 (14) 

0.2 

3 (1, assumed) 

3 (5) 

Legume vegetables 0.2 

and foliage of 

0.2 

0.2 

0.065 
Product 

Potato 

Protected seed 

use' 

Peanut 

Spices 

Strawberry 

Tobacco 

subgroup 

Cucurbit vegetables 

0.065 

0.065 

Fruiting vegetables 

Max Application 

Rate 

(Ib ai1A) 

0.065 

0.065 

0 

0.065 

0.098 

Tuberous and corm 0.065 

vegetables I 

Proposed 

Leafy vegetables 

\, 

3 (5) 

3 (5) 

3 (5) 

New Uses 

1 application to soil 

at planting plus 

additional 

chemigation or foliar 

applications 

3 (7) 

Brassica, leafy 

vegetables3 

Bulb vegetables; 

onion, bulb 

1 application to soil 

at planting plus 

additional 

chemigation or foliar 

at planting plus 

additional 

chemigation or foliar 

Max No. of Apps (min. interval, 

days) 

3 (5) 

0.2 

0.2 

3 (3) 

3 (7) 

2 (3) 

0.2 

0.2~ 

0.2 

0.098 

0.065 

at planting plus 

additional 

chemigation or foliar 

Max Seasonal Rate 

(Ib ai/A) 

0.2 

0.2 

0 

0.2 

0.2 

- / applications 

0.065 1 3 (5) (30 Peanuts 0.065 0.2 

Root and tuber 1 0.065 1 3(3) ) 0.2 

I 1 tuber vegetables6 1 1 , p DuPont Altacor J 

Bananalplantain ( 0.099 1 2 (10) 1 0.2 

Canebeny subgroup 1 0.099 / 2 (14) 1 0.2 

0.2 I 

vegetables (except 1 

potato)6 

Leaves of root and 0.065 

1 Cacao 

Citrus 

Coffee 

Cotton 

Figs 

I Grape 

Olives 

Persimmons 

0.099 

0.099 

0.099 

0.099 

0.099 I 

0.099 

0.099 

0.099 

2 (7) 

2 (7) 

2 (14) 

0.2 

0.2 

0.2 , , 

2 (5) 

2 (7) 

2 (7) 

2 (7) 

2 (7) 

0.2 J 

0.2 

0.2 

0.2 

0.2 
Pomegranates 1 0.099 1 2 (7) 1 0.2 

P Potato 0.2 

Max Application 

climbing subgroup 1 

Product use1 Rate (min. interval, 

Pome fruits 0.099 

Max No. of Apps 

Small fruit vine 

Max Seasonal Rate 

Bushberry subgroup 1 0.099 1 2 (7) 1 0.2 1 

& Large shrubltree 0.2 

0.099 

Stone fruit 

Tree nuts 

Tropical fruit 

\, 

0.2 

2 (7) 1 0.2 

'2 I I 1 

Tea 1 0.099 1 2 (14) / 0.2 

Proposed and previously assessed uses are foliar applications (ground and air) unless indicated otherwise. 2 The label allows for a single application of chlorantraniliprole-treated seed (maximum single application of 0.054 

lbs ai/A) followed by foliar applications of chlorantraniliprole up to a seasonal maximum application not to exceed 

0.2 lbs ai1A (combination 

0 

of seed and foliar treatments). Foliar applications are assumed to be limited to the 

0.099 

0.099 

0.099 

subgroup 

Low growing berry 

application rates for field corn (Coragen label). The fikld corn seed label (DPX-E2Y45 625FS) limits the number of 

foliar applications to two within a 30 day period. 3 Although a request was not made for these labeled uses, risk was assessed because it does not appear that they 

were included in previous risk assessments. 

One chemigation application may be applied to the soil following an application to the soil at planting (0.132 lb 

ai/A maximum from combination of soil-at-planting method and chemigation). No more than 0.2 Ib aiiA of 

chlorantraniliprole containing products may be applied seasonally per acre, therefore the label presumably allows for 

foliar applications following the soil applications. An interval is not specified between soil-at-planting and 

subsequent chemigation or foliar applications. 

Okra and peanut uses were requested at application rates that were previously assessed (DP361404) and so are not 

reassessed. 

6 Ti Palm is a proposed use but was not included on the label. It was assumed that it was intended to be included in 

the root and tuber vegetables and leaves of root and tuber vegetables groupings. 

6. Exposure Summary 

2 (7) 

2 (7) 

2 (10) 

0.099 1 2 (7) 

6.1. Terrestrial Exposure 

0.2 

0.2 

0.2 

0.2 

Terrestrial exposure was quantified only for chlorantraniliprole-treated seed (field corn) 

applications. Exposure was not quantified for the proposed non-seed uses because no LOCs 

were exceeded for non-listed terrestrial plants (risks to listed terrestrial plants cannot be 

precluded due to a non-definitive NOAEC), birds, and mammals in DP338512 (2007) at single 

and annual application rates that are equivalent to those considered in this assessment. 

Therefore, no LOCs are expected to be exceeded for birds, mammals, or non-listed terrestrial 

plants for the proposed non-seed uses. 
Seed Treatment 

Exposure for the proposed field corn seed treatment is co'mplex. The label allows for application 

of chlorantraniliprole-treated seed (maximum single application of 0.054 lbs ai/A) followed by 

foliar applications of chlorantraniliprole up to a seasonal maximum application not to exceed 0.2 

lbs ai/A (combination of seed and foliar treatments). Foliar applications are assumed to be 

limited to the application rates for field corn (Coragen label). The field corn seed. label (DPXE2Y45 625FS) limits the number of foliar applications to two within a 30 day period. Due to 

model limitations, separate EECs were calculated in T-REX (v 1.4.1) for the seed treatment 

(Table 3) and the subsequent foliar applications (Table 4). 

Table 3. Estimated Environmental Concentrations from Proposed Application of 

Chlorantranili~role-Treated Seed 

I Based on proposed maximum planting density of 33,000 seeds/A (DPX-E2Y45 625FS label) and assuming 1600 

field corn seedsllb (provided by BEAD 11/9/2010, Appendix 1) 

Although the label does not specify how the seed should be applied, it was assumed that the seed is intended to be 

planted in a manner that incorporates it into the soil. Given that the label does not specify an application method, 

exposure was estimated assuming planting methods that result in the least amount of incorporation (85%) 

documented in the T-REX user's guide. 

Table 4. Terrestrial Food-Item Residue Estimates for Mammals and Birds for Proposed 

Foliar Applications of Chlorantraniliprole Following Application of ChlorantraniliproleTreated seed1 

Mammals 

Dose-Based EECs 

35 19.23 

15 27.82 12.75 15.65 1.74 

8.8 1 

-- 

10.82 1.20 0.27 

I Dietary-Based EECS~ 
I Avian 1 

1 Dose-Based EECs 

6.2. Aquatic Exposure 

20 

100 

1000 - 

Dietary-Based EECS~ 

The PRZMIEXAMS input parameters for chlorantraniliprole are shown in Table 5. Inputs are 

equivalent to inputs used in previous assessments (DP3385 12 and DP36 1404). 

NA 1 29.18 

Since the last risk assessment, two fate studies have been submitted to the Agency and are under 

review: Aquatic Field Dissipation of Chlorantraniliprole (MRID 48075303) and Method 

Validation for Chlorantraniliprole and its Products IN-EQW78, IN-ECD73 and IN-LBA24 in 

Soil (MRID 48075302). 

33.23 

18.95 

8.48 

Table 5. PRZMIEXAMS Input Parameters for Chlorantraniliprole 

Input Parameter: / Value: I Comment: I source: 

Based on maximum of two foliar applications of 0.065 Ib ai/A (maximum single application) with a minimum 

application interval of 7 days. The label permits two foliar applications within 30 days of planting the treated seed. 

A third foliar application of 0.016 Ib ai/A is permitted by the label based on the seasonal maximum of 0.2 lbs ai/A 

but not until 30 days after planting the treated seed. Model limitations prevent calculation of EECs for the three 

application scenario due to unequal application rates and intervals. However, a third application is not expected to 

increase the EECs given the relatively low application rate and length of time between foliar applications. 2 Based on default foliar dissipation half-life of 35 days 3 Size Class not used for dietary EECs 

13.37 

Bushberrv Subgroup 13-07B: 

NY Grapes (not applicable for cranberry) 

Provisional Cranberry Model (applicable for cranberry) 

15.23 

8.69 

3.89 

Large ShrubITree Bern Subgroup 13-07C: 

CA, FL, MI, NJ, OR, TN Nursery 

16.41 

Low Growing Berry subgroup 13-07G: 

FL Strawberry 

18.69 

10.66 

4.77 

Tea (HI and SC only): 

The FIRST Model was employed. 

1.82 

Bulb Ve~etables: Onion, Bulb Subgroup 3-07A: ) CA, GA Onion 

2.08 

1.18 

0.53 

NA 

NIA 

0.46 

0.26 

0.12 

Cucurbit Vegetables: 

, FL Cucumber; MI, MO, NJ Melon 
nput Parameter: 

vlaximum Single 

Ypplication Rate 

bs a.i./acre (kg a.i./ha) 

Value: 

Fruiting Vegetables: 

:A, FL, PA Tomato 

Leaves of land Root and Tuber Vegetables: 

FL Carrot; ID, ME Potato; MN Sugarbeet, 

NC Sweet Potato 

Brussicu (Cole) and Leah Vegetables: 

LA Cole Crop, CA Lettuce 

Field Corn: 

KS Corn 

Bushberry Subgroup 13-07B: 

0.100 (0.112) 

Large ShrubITree Berry Subgroup 13-07C: 

0.100 (0.112) 

Low Growinn Bew subgroup 13-07G: 

0.100 (0.1 12) 

Tea (HI and SC only): 

0.100 

Bulb Vegetables: Onion. Bulb Subgroup 3-07A: 

0.067 (0.075) 

Cucurbit Vegetables: 

0.100 (0.112) 

Fruiting Vegetables: 

0.100 (0.112) 

Leaves of /and Root and Tuber Vegetables: 

0.067 (0.075) 

Brassica (Cole) and Leaf% Vegetables: 

0.100 (0.1 12) 

Field Corn: 

0.054 (0.061) 

0.146 (0.164) 

~roposed rates 

- 

jroposed label 
nput Parameter: 

Ipplications per Year 

Ypplication Interval 

days) 

Value: 

Bushbeny Subgroup 13-07B: 2 

Large ShrublTree Berry Subgroup 13-07C: 2 

Low Growing Berry subgroup 13-07G: 2 

Tea (HI and SC only): 2 

Bulb Vegetables: Onion, Bulb Subgroup 3-07A: 3 

Cucurbit Vegetables: 2 

Fruiting Vegetables: 2 

Leaves of land Root and Tuber Vegetables: 3 

Brassica (Cole) and Leafy Vegetables: 2 

Field Corn: 1 

Bushberry Subgroup 13-07B: 7 

Large ShrublTree Berry Subgroup 13-07C: 7 

Low Growing Beny subgroup 13-07G: 7 

Tea (HI and SC only): 14 

Bulb Vegetables: Onion, Bulb Subgroup 3-07A: 

Cucurbit Vegetables: 10 

Fruiting Vegetables: 10 

Leaves of land Root and Tuber Vegetables: 3 

Brassica (Cole) and Leafy Vegetables: 3 

Field Corn: 0 

Zomment: 

abel directions. Label 

,pecifies rates per acre per 

:rop. If crops are rotated 

vith those on which 

:hlorantraniliprole is used, 

[early rates may be higher. 

jroposed application 

ntervals 

jource: 

reposed label 

)reposed label 
nput Parameter: 

)ate of Initial 

ipplication 

scenarioldaylmonth) 

Value: 

Bushberry Subgroup 13-07B: 

NY Grapes: 07-10 

Provisional Cranberry Model: 07-10 

Large ShrubITree Berrv Subgroup 13-07C: 

CA Nursery: 24- 1 0 

FL Nursery: 23-12 

MI Nursery: 23-12 

NJ Nursery: 23-12 

OR Nursery: 23- 12 

TN Nursery: 14-10 

Low Growing Berrv subgroup 13-07G: 

FL Strawbeny: 07-02 

Tea (HI and SC only): 

The FIRST Model was employed. 

Bulb Vegetables: Onion. Bulb Subgroup 3-07A: 

CA Onion: 18-05 

GA Onion: 18-05 

Cucurbit Vegetables: (G, C, S) 

FL Cucumber: 04-12,04-12,25-12,02-10 

MI Melon: 09-08, 09-08, 09-06, 16-04 

MO Melon: 25-07, 25-07,20-05, 27-03 

NJ Melon: 15-07, 15-07, 10-06, 17-04 

Fruiting Vegetables: (G, C. S) 

CA Tomato: 26-08,26-08, 10-04, 15-02 

FL Tomato: 09-05,09-05, 13-03, 18-01 

PA Tomato: 09-10,09-10,26-05,02-04 

Leaves of land Root and Tuber Vegetables: (A, G) 

FL Carrot: 15-0 1 

ID Potato: 09-09 

ME Potato: 28-09 

MN Sugarbeet: 08-10 

NC Sweet Potato: 15-09 

Brassica (Cole) and Leah Vegetables: 

CA Cole Crops: 22-02 

CA Lettuce: 05-05 

Field Corn: 

KS Corn: 05-10 

Comment: 

For the majority of crops, 

the date of initial applicatior 

was calculated from the Pre. 

Harvest Interval (PHI) and 

application interval as 

written on the proposed 

labels. In addition, the date 

3f initial application for 

:hemigation was 40 days 

after crop emergence. Soil a 

planting applications were 

14 days before crop 

:mergence. 

A = aerial 

S = ground 

E = chemigation 

S = soil at planting (infurrow spray, transplant 

water treatment. hill drench. 

surface band, soil shank 

injection) 

iource: 

:rap Scenarios 
nput Parameter: 

ipplication Method 

" Input 

lncorporation Depth 

:cm.) 

Value: 

Bushberw Subgroup 13-07B: 

Foliar: aerial and ground 

Large ShrubITree Berry Subgroup 13-07C: 

Foliar: aerial and ground 

Low Growing Berrv subgroup 13-07G: 

Foliar: aerial and ground 

Tea (HI and SC only): 

Foliar: aerial and ground (aerial was modeled) 

Bulb Vegetables: Onion. Bulb Subgroup 3-07A: 

Foliar: aerial and ground 

Cucurbit Vegetables: 

Foliar: aerial and ground 

Chemigation 

Soil at Planting 

Fruiting Vegetables: 

Foliar: aerial and ground 

Chemigation 

Soil at Planting 

Leaves of /and Root and Tuber Vegetables: 

Foliar: aerial and ground 

Brassica (Cole) and Leafi Vegetables: 

Soil at Planting 

Field Corn: 

Seed treatment followed by foliar application 

2 (foliar) 

8 (seed treatment) - 

2.5 (seed treatment) 

abel directions 

iource: 

~roposed label 

)reposed label 

xoposed label 
Input Parameter: 

IPSCND Input I-- 

Spray Drift Fraction 

Application Efficiency 

Molecular Mass 

(dm011 

Vapor Pressure at 25OC 

(torr) 

Henry's Law Constant 

(atm-m3/mol) 

Solubility in Water 

Organic Carbon 

Partition Coefficient 

Aerobic Soil 

Metabolism Half-life 

(days) 

Aerobic Aquatic 

Metabolism Half-life 

I value: I Comment: I source: I 

Bushberry Subgroup 13-07B: 3 

Large ShrubITree Beny Subgroup 13-07C: 3 

Low Growing Beny subgroup 13-07G: 3 

Tea (HI and SC only): N/A (employed FIRST model) 

Bulb Vegetables: Onion, Bulb Subgroup 3-07A: 2 

Cucurbit Vegetables: 3 

Fruiting Vegetables: 3 

Leaves of land Root and Tuber Vegetables: 2 

Brassica (Cole) and Leafy Vegetables: 3 

Field Corn: 1 

1 = remaining pesticide on 

foliage is converted to 

surface application to the 

top soil layer 

2 = remaining pesticide on 

foliage is completely 

removed after harvest 

3 = remaining pesticide on 

foliage is retained as surface 

residue and continues to 

undergo decay. 

US EPA. 2005 

Input parameter 

guidance (USEPA, 

2009) 

0.05 (aerial) 

0.01 (ground) 

Input parameter 

guidance 

(USEPA, 2009) 

0 (chemigation) 

0.01 (soil at planting) 

0.95 (aerial) 

0.99 (ground) 

1.0 (chemigation) 

0.99 (soil at planting) 

MRID 46889 130 

-- 

estimated 

Calculated 9oth percentile of 

mean' .Mean= 509 days. 

SD= 252 days, t= 1.40, n= 9 

*Several reported half-lives 

in MRID 46889124 

were not used because of 

poor fit with first-order 

degradation model 

calculated from 

solubility and vapor 

- 

oressure 

represents the average Koc 

from 5 values 

Calculated 9oth percentile of 

mean'. Mean= 178 days, 

SD= 74.95 days. t= 3.078, 

n=2 

MRID 46889123 

MRID 46889124 

MRID 46889015 

MRID 46889124 

MRID 46889016 1 
I 

Anaerobic Aquatic 624 3 x 208 days (EFED DuPont 14568 

Aqueous Photolysis 

Half-life (days) 

Metabolism Half-life 

(davs) 

Hydrolysis Half-lives 

(days) 

NIA = Not Applicable ' = t ,,,, =Mean+(tw..,*~~)ld~-l 

= Chemigation (< 1% spray drill as described in httD:/lwww.a~drift.com/PDF FlLESlChen~.~df - modeled as 0%) ' = Koc values include 153, 509,272. 526, 180. 

' = EFED recalculated first-order half-lives for both benzo- and pyrazole-labeled chlorantraniliprole. The calculated half-lives are based on aerobic 

soil metabolism data in non-sterile soil at 25'~. Half-lives used in the assessment include 577.6, 537.3, 374.6,410.1, 246.6, 228. 888.6, 924.1, 396 

days. '= The 90' percentile of the mean half-life for chlorantraniliprole was 600 days for half-lives values presented in the OECD Chlorantraniliprole 

Volume 3(1): Annex B, Environmental Fate and Behavior. (mean = 491 ( 886, 539,380,233,323. 629,423. 518 days); SD=203; t90n.1=1.417; N=8 

6= A single value half-life was used because of the insensitivity of PRZMIEXAMS modeling to anaerobic aquatic metabolism. 

!jttp://ww\v.e~a.gov/oppefed I /models/waterlinput parameter guidance.htm 

Guidance) 

The estimated environmental concentrations (EECs) were generated using EFED's standard suite 

of models. In addition, the provisional cranberry model was utilized to assess cranberry, the Tier 

1 GENEEC model was used to assess dried tea leaves, and a manual PRZMIEXAM run was 

performed to assess field corn since the seed treatment can be followed by a foliar application. 

A representative PRZMIEXAM model input and output data for FL Cucumber (soil at planting 

application) is attached in Appendix 2. In addition, the provisional cranberry model output is 

attached in Appendix 3. 

0 (stable) 

Results of the PRZMIEXAMS modeling are presented in Table 6. Peak EECs ranged from 0.42 

to 8.17 pg/L for all proposed uses except cranberries which were considerably higher at 63.56 

pg/L. Peak EECs in the 2007 assessment (D3385 12) ranged from 0.41 to 11 pg/L and the 

highest EEC in the 2009 assessment (D361404) was 100 pg/L. Therefore, potential exposures 

and risks from the proposed new uses are within the range of potential exposures and risks 

described in the 2007 and 2009 assessments. 

PH 7 1 MRID 46889017 1 

Table 6. Chlorantraniliprole Estimated Environmental Concentrations (EECs)' for 

Cranbeny 

Surface Water based on-selected Crop Scenarios 

Provisional Cranbeny 1 Model 1 -- 1 63.56 62.36 1 60.12 1 

Label Use 

Laree ShrubITree Berrv 1 A 1 1.98 1 1.62 1.21 1 v 

Subgroup 13-07C 

(October 24 - foliar) 

PRzlWEM 

sce!mtriol 

(ritst app tlate) 

Surface Water 

DupontTM ~ltacor@ insect control with R~NAX~~R@ 

~ethod~ 

Bushbeny Subgroup 

13-07B 

Peak 

EEC 

@@I 

NY Grapes 

-- (October 7 - foliar) 

NY Grapes 

(October 7 - foliar) 

21-Day 

EEC 

(crg/L) 

A 

G 

60-Day 

EEC 

(W) 

1.60 1.57 1.53 
Proposed Label Use 

Low Growing Beny 

subgroup 13-07G 

- - 

FL Nursery 

(December 23 - foliar) A 2.58 

PRZMEXAMS 

scenario' 

(first app date) 

FL Nursery 

(December 23 - foliar) G 2.27 

MI Nursery 

(December 23 - foliar) 

MI Nursery 

(December 23 - foliar) 

~ethod' 

NJ Nursery 

(December 23 - foliar) A 3.48 

Peak 

EEC 

(P&) 

NJ Nursery 

(December 23 - foliar) G 3.23 

OR Nursery 

(December 23 - foliar) 

OR Nursery 

(December 23 - foliar) 

TN Nursery 

(October 14 - foliar'l 

TN Nursery 

(October 14 - foliar) G 2.3 1 

FL Strawberrv 1. A.c 

H 4.40 (February 7 - foliar) 

FL Strawbeny 

(Februaw 7 - foliar) 

~ ;;and SC only) GENEEC~ - foliar 

I DopontTM coragenQ inseet control with RYN*XPY. @ 

2 1 -Day 

EEC 

(~gn,) 

Bulb Vegetables: Onion, 

Bulb Subgroup 3-07A 

60-Day 

EEC 

(PgfL) 

1 Cucurbit Vegetables 

Leaves of Root and Tuber 

Vegetables 

CA Onion 

GA Onion 

FL Tomato 
Proposed Label Use 

PRZMIEXAMS 

scenario' 

(first app date) 

ME Potato 

(September 28 - foliar) 

ME Potato 

(September 28 - foliar) 

MN Sugarbeet 

(October 08 - foliar) 

MN Sugarbeet 

(October 08 - foliar) 

NC Sweet Potato 

(September 15 - foliar) 

NC Sweet Potato 

(September 15 - foliar) G 1.73 1.57 

CA Cole Crop and (February 22 - soil at Vegetables G 3.03 2.62 

~ethod~ 

A 

G 

A 

G 

A 

DupontTM DPX-E2Y45 

Field Corn 

Peak 

EEC 

(PI&) 

Bold numbers denote maximum EEC values. 2 A = aerial application, G = ground application, S = Soil at Planting (may include: in-furrow spray, transplant water 

treatment, hill drench, surface band, soil shank injection) ' The Provisional Cranbeny Model was used to assess cranbeny. The model does incorporate a degradation 

component. 

4 GENEEC was uses to assess tea (dried tea leaves) use. 5 A manual PRZMJEXAM run was employed for corn to capture seed treatment followed by a foliar application. 

CA Lettuce 

(May 05 - soil at planting) 

2 1 -Day 

EEC 

(PI&) 

G 

60-Day 

EEC 

(PI&) 

1 

2.09 

1.95 

1.44 

1.03 

2.00 

4.45 

625FS Field Corn Seed Treatment 

KS Corn 

(October 05 - seed, foliar) 6.02 

2.0 1 

1.87 

1.28 

0.94 

1.83 

3.74 

S, F 

1.98 

1.83 

1.14 

0.82 

1.43 

2.56 

5.14 4.13 
7. Ecological Effects Summary 

Table 7 presents a summary of toxicity data used in this risk assessment. A more detailed 

description of the toxicity data can be found in the 2007 assessment (DP338512). 

Since the last risk assessment, several studies have been submitted to the Agency and are under 

review: acute oral toxicity to zebra finch (MRID 48216601), terrestrial plant (6 crops) seedling 

emergence study (MRID 482 16602), terrestrial plant (3 crops) vegetative vigor study (MRID 

48216603), and a crayfish field study (MRID 48075301). 

Table 7. Effects Measurement Endpoints Used in Quantitative Risk Assessment 

terrestrial 

invertebrates) 

Mammals 

Terrestrial plants 

Reproduction - bobwhite NOAEC = 120 mgikg-diet 

Survival - estimated rat >5000 mag-diet 

Effects Measurement Endpoint 

Survival - bobwhite and mallard >5620 mg/kg-diet 

Survival - bobwhite LDso >2250 mag-bw 

Reproduction - rat NOAEC = 20,000 mglkg-diet 

Vegetative Vigor Dicot EC25 >300 g/ha 

Dicot EC5 < 300 gha 

Monocot ECZ5 >300g/ha 

Monocot EC5 < 300gha 

Seedling Emergence Dicot ECz5 > 300 giha 

Dicot EC5 < 300 g/ha 

Monocot EG5 < 300 ha 

Rationale 

Most sensitive tested 

Most sensitive tested 

Most sensitive tested 

Most sensitive tested LD50 

adjusted to estimate dietary 

equivalent (1 00% bw 

consumed/day) 

Most sensitive tested 

Most sensitive tested 

Most sensitive tested 

Most sensitive tested 

Most sensitive tested 

Most sensitive tested 

Most sensitive tested 

Most sensitive tested 

invertebrates I Reproduction Aaphnid NOAEC = 0.0044 mgiL I Most sensitive tested 

Freshwater fish I Survival - rainbow trout 96-hr LCso > 13.8 mg/L I Most sensitive tested 

1 Freshwater 

I Reproduction - rainbow trout NOAEC = 0.1 l-mg/~ I Most sensitive tested 

1 Estuarineimarine 1 

0 

Survival - eastern oyster 48-hr ECS0 = 0.0399 mglL 1 Most sensitive tested 

Survival - daphnid 48-hr ECso = 0.01 16 mg/L 

1 Estuarineimarine I Survival- sheepshead minnow 96-hr LC50 > 12 mg/L I Most sensitive tested 1 

Most sensitive tested 

invertebrates 

and NOEC = 1.78 mg/L 

Growth/reproduction - Vascular EC50 > 2 mg/L 

and NOAEC = 2 me/L 

Chronic effect estimate - NOAEC = 0.024 rng/~- 

fish 

Aquatic plants 

Most sensitive tested 

Most sensitive tested for 

acute (oyster) adjusted with 

available ACR 

Reproduction 1 sheepshead minnow NOAEC = 1.38 mg/L 

Growthireproduction - Non-vascular EC5, > 1.78 mg/L 

Most sensitive tested 

Most sensitive tested 1 
8. Ecological Risk Summary 

8.1. Terrestrial Organisms 

LOCs were not exceeded for terrestrial birds, mammals, or non-listed plants in the 2007 

assessment. EECs for the proposed non-seed uses are not expected to be higher than those used 

in the 2007 assessment; therefore, potential risk from non-seed uses was not re-evaluated for 

terrestrial organisms. However, as in the 2007 assessment, there is concern for potential risk to 

terrestrial invertebrates and risk to listed plants cannot be precluded. 

Seed Treatment 

The label allows for planting of chlorantraniliprole-treated seed (field corn) followed by foliar 

application of chlorantraniliprole. Due to model limitations, separate EECs were calculated in TREX (v 1.4.1) for the seed treatment and the foliar applications. The overall risk from the seed 

treatment plus subsequent foliar applications is characterized by considering the individual risk 

from each application method. 

Based on the proposed application rates (seed and subsequent foliar), EECs for terrestrial plants 

and invertebrates are not expected to be any higher than those used in the 2007 assessment, thus 

risk was not re-evaluated. As in the 2007 assessment there is concern for potential risk to 

terrestrial invertebrates and risk to listed plants cannot be precluded due to a non-definitive 

NOAEC. 

Mammals 

RQs were not calculated for acute toxicity because the acute rat study resulted in a non-definitive 

endpoint. However, the EECs from both the seed treatment and subsequent foliar applications 

are less than l/loth of the highest dose tested the rat study; therefore acute risk is not expected for 

listed or non-listed mammals. 

The chronic LOC was not exceeded for mammals based on either the seed treatment (RQ = 0.13) 

or the subsequent foliar applications (RQ 5 0.01). Chronic risk to mammals is not expected from 

the seed treatment and subsequent foliar applications. 

Birds 

RQs were not calculated for acute toxicity because the acute avian oral toxicity studies resulted 

in non-definitive endpoints. The EEC (avian nagy dose) from the seed treatment alone is more 

than l/loth (ca. 40%) of the highest dose tested in these studies. When considered alone, 

subsequent foliar applications are less than l/loth of the highest dose tested in the acute avian 

studies, but add to the exposure and risk from the seed treatment. A 20-pound bird could eat a 

maximum of four chlorantraniliprole-treated seeds without a concern from the seed treatment 

alone (i.e., the EEC would be less than l/loth of the highest dose tested in the acute avian 

studies). The same bird eating 100% of its daily diet as treated seeds would mean consumption 

of about 17 seeds per day. Given the results of this analysis and the non-definitive toxicity 

endpoint, acute risk to listed birds cannot be precluded. 
The chronic LOC was exceeded for birds based on the seed treatment alone (RQ = 22.05). 

Subsequent foliar applications do not exceed the LOC (RQ 5 0.24) when considered alone, but 

do add to the exposure and risk from the seed treatment. 

8.2. Aquatic Organisms 

All proposed new uses produced aquatic EECs that were lower than those reported in the 2009 

assessment (D361404) for rice seed treatment, therefore, RQs are not reported for each proposed 

new use. 

Fish 

LOCs were not exceeded for freshwater or estuarinelmarine fish on either an acute (RQs F 0.01) 

or chronic (RQs F 0.55) basis. Therefore, risk to fish is not expected. 

Invertebrates 

As in the 2009 and 2007 assessments, LOCs were exceeded for freshwater and estuarinelmarine 

invertebrates on both an acute and chronic basis. The proposed cranberry use EECs were 

considerably higher than EECs for any other use evaluated in the past or in the current analysis 

except for rice seed treatment (2009 assessment). Table 8 compares the difference in RQs for 

the proposed cranberry use and the proposed cucurbit use which yielded the second highest 

EECs. Freshwater invertebrates exceed the LOC (acute, chronic, or both) for all proposed uses 

and estuarinelmarine invertebrates exceed the LOC (acute, chronic, or both) for all proposed uses 

except the bushberry subgroup. Freshwater acute RQs ranged from 0.03 to 5.48 and chronic 

RQs ranged from 0.08 to 14.17. Estuarinelmarine acute RQs ranged from 0.01 to 1.59 and 

chronic RQs ranged from 0.01 5 to 1.69. Risk to aquatic invertebrates is expected from the 

proposed uses on an acute and chronic basis. 

Freshwater 

Invertebrates 

I I I I 

Scenarios resulting in the highest and second highest EECs for the proposed uses I 

2 RQ = peak EEC/ECSo 

Estuarine Marine 

Invertebrates 

RQ = 2 1 -day EEC/NOAEC 

Bold values exceed LOC: (A) Acute LOC = 0.05 for endangered species, 0.1 for restricted use, and 0.5 for nonlisted species and (B) Chronic LOC = 1 

Cranberry 

Cucurbit (FL Cucumber) 

Cranberry 

Cucurbit (FL Cucumber) 

63.56 

8.17 

63.56 

8.17 

14.17 

1.69 

62.36 5.48 

62.36 

7.44 

7.44 0.70 

1.59 

0.20 

2.60 

0.3 1 
Aquatic Plants 

LOCs for listed species were not exceeded for vascular (RQs 5 0.032) or nonvascular (RQs i 

0.036) aquatic plants. Therefore, risk to listed aquatic plants is not expected. 

RQs were not calculated for non-listed species because the available studies yielded nondefinitive endpoints (ECSo). However, a comparison of EECs to study effects may be used to 

evaluate potential risk. The EECs for the proposed uses are at least 30 times less than the ECSOs, 

thus risk to non-listed aquatic plants is not expected. 

9. Endangered and Threatened Species 

Table 9 summarizes the conclusions of potential concerns for direct and indirect effects to 

federally-listed threatened and endangered species (listed species). 

Table 9. Potential Effects to Federally Listed Taxa I I I I 

Listed Taxa 

Terrestrial and semi-aquatic plants - 

monocots 

Aquatic phase amphibians 

Freshwater crustaceans 

Direct Effects 

yes1 

Mollusks 

Marinelestuarine fish 

direct effects on terrestrial invertebrates 

3 direct effects on freshwater invertebrates 

4 direct effects on estuarinelmarine invertebrates 5 direct effects to terrestrial plants at the listed species level of concern suggests concern of animals with obligate 

relationships to a plant species 6 direct effects on birds and terrestrial-phase amphibians 

Indirect Effects 

~es~.~ 

No 

Marinelestuarine invertebrates 

LOCATES is used to identify listed species that may be located within the same county as the 

proposed new uses. However, due to the wide range of proposed uses, both in crop type and 

yes3" 

Yes (may be subject to further 

evaluation) 

No 

- - - - 

geographic distribution, it is possible that every listed species in the United States (except for 

aquatic vascular plants) could be either directly or indirectly affected as a result of applications 

of chlorantraniliprole to the proposed crops. Therefore, LOCATES was not run. 

~~~3.4.5 

Yes43s 

insufficient data to preclude risk 

Yes 

Yes 

Yes43s 

yes33s 
10. References 

USEPA. 2005. PRZM-3, A Model for Predicting Pesticide and Nitrogen Fate in the Crop Root 

and Unsaturated Soil Zones: Users Manual for Release 3.0. May 2005. 

USEPA. 2009. Guidance for Selecting Input Parameters in Modeling the Environmental Fate 

and Transport of Pesticides, Version 2.1. U.S. Environmental Protection Agency, Office 

of Prevention, Pesticides and Toxic Substances, Office of Pesticide Programs, 

Environmental Fate and Effects Division, October 22,2009. 

USEPA. 2010. Water Models. U.S. Environmental Protection Agency, Pesticides: Science and 

Policy. Online at: htt~://www.epa.gov/oppefedl /models/water/ 
Appendix 1. Seed Weight and Planting Rates 

Sources: 

1. Dome Agricultural Report: Crop Planting and Storage Tables, p. 1 19 

2. Alberta Canada guide to Calculating seeding rates. httu://wwu.aaric.gov.ab.caia~dexl1001100 97-1 .html 
Appendix 2. Representative PRZMIEXAMS Output: FL Cucumber - Soil at Planting 

stored as FLcucumberS.out 

Chemical: Chlorantranlioprole 

PRZM environment: FLsucumberSTD.txt modlfled Wedday, 13 June 2007 at 11:19:24 

EXAMS environment: pond298.e~~ modlfied Tueday. 26August 200Sat 05:14:07 

Metfile: w12844.dvf modified Tueday. 26 August 2008 at 05:14:21 

water segment concentrations (ppb) 

Year Peak 96 hr 21 Day 60 Day 

1961 1.52 1.46 1.33 

1962 0.59 0.56 0.48 

1963 8.28 8.05 7.61 

1964 11.37 10.93 9.77 

1965 16.10 15.42 13.67 

1966 4.44 4.34 3.95 

1967 4.01 3.93 3.50 

1968 5.60 5.38 4.72 

1969 2.75 2.65 2.43 

1970 0.87 0.85 0.77 

60 Day 

10.24 

7.50 

5.92 

4.03 

3.89 

3.52 

3.25 

2.96 

2.88 

90 Day Year1 y 

7.94 2.72 

7.44 5.73 4.74 1.55 

Average of 0.79 

Inputs generated by pe5.pl - Novemeber 2006 

Data used tor this run: 

Output File: FLCucumberS 

Metflle: w 12-4. dvf 

PRZM scenario: FLcucumberSTD.txt 

EXAMS environment file: pond298.exv 

Chemlcal Name: Chloranrraniliprole 

Descroptlon Variable NanValue Units Comments 

Molecular weight mwf 483.15 g/mol 

Henry's Law Const. henry 3.1OE-15 atm-mA3/mol 

Vapor Pressure vapr 1.57E-13 torr 

Solubility so1 1.023 mg/L 

Kd Kd 

+'oc 

-s/L 

Koc 328 mg/L 

Photolysis half-lsfe k-3 P 0.31 days Hal+-life 

Aerobic Aquatic Metabolism kba- 341.13 days Halfife 

Anaerobic Aquatic Metabolism kbacs 624 days Hatfife 

Aerobsc Sot, Mefabolism as- 631.76 days Halfife 

Hydrolys'5 OH 7 0 days Half-life 

Method: CAM 2 integer See PRZM manual 

,ncorporat,on Depth: DEPl cm 

npplication ~=te: TAPP 0.112 *=/ha 

Applicafion Efficiency: APPEFF 0.99 fraction 

Spray Drift DRFT 0.01 fraction ot applicafion rate applied to pond 

Application Date Date 02- 10 dd/mm or dd/mmm or dd-mm or dd-mr-rn 

tnterva1 1 inteTYa1 5 days set to oor delete line for single app. 

app. rate 1 apprate 0.112 *=/ha 

Record 17: F I LTRA 

lPSCND 3 

UPTKF 

Record 18: PCVKRT 

PLDKRT 

FEXTRC 0.5 

Flae for Index Res. Run I R EPA Pond 

Flag for runoft calc. RUNOFF none none, monthly or total(average of entire run) 
Appendix 3. The Provisional Cranberry Model Output 

1 ~mvisiona~~ranben~ MO~~I Equations: EEC= EECO'exp (&~*(&*AAM t112) t (dsed'0'ArAM 1112) t jdsedt p'~d ~r~~ti12)1(~ t dsedyot p' ~d)))] 

- r 

Inputs Model Parameters Calculated Parameters 

Parameter Value Parameter Value Parameter Valw 

I~@~cabm iate (IklA) 0.201 \water colmndepth(m) 1 03051 

aqdc metablism tl, id:, Isdimat psiv 1 oaml ~SM wr (II~) rrionl 

Aerobic soil meEabolrsm (d) 

Ka: (Ukg) 328 

if IN Koe entet Kd (Uirg) 

Aerobic @ic metabdism (d) 341.13 

Ap rate, 7 d befwe PHI (IbsIA) = 0.10 

Ap rate, (PHI : 1 Odays) (IhlA) = 0.10 

Total IMA at hamt = ' 0.20 

Sedimml depth (m) 

Oynic~onof~mm! 

SediM bulk density (kqim3) 

0.01 

0.n 

13W 

Kd inptA(Ukg) 3.28 

uun k(1l) 1 iKQX2 

AM rate k (lid) , 0.W1111