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                                                                   EXHIBIT 10.41

                                 AMENDMENT NO. 4

                                       TO

                       INVERNESS MEDICAL INNOVATIONS, INC.

                      2001 STOCK OPTION AND INCENTIVE PLAN

     The Inverness Medical Innovations, Inc. 2001 Stock Option and Incentive
Plan (the "Plan") is hereby amended as follows, effective as of the date
approved by the Board as set forth below.

1. Section 2(a) is hereby deleted in its entirety and replaced with the
following:

     "Committee. The Plan shall be administered by either the Board or a
     committee of not less than two Independent Directors (in either case, the
     "Administrator"), as determined by the Board from time to time; provided
     that, for purposes of Awards to Directors or Section 16 officers of the
     Company, the Administrator shall be deemed to include only Directors who
     are Independent Directors and no director who is not an Independent
     Director shall be entitled to vote or take action in connection with any
     such proposed Award."

2. Section 2(b)(iv) is hereby deleted in its entirety and replaced with the
following:

     "to determine and modify from time to time the terms and conditions,
     including restrictions, not inconsistent with the terms of the Plan, of any
     Award, which terms and conditions may differ among individual Awards and
     grantees, and to approve the form of written instruments evidencing the
     Awards; provided that, other than by reason of death, disability,
     retirement or Change of Control, the Administrator shall not accelerate or
     waive any restriction period applicable to any outstanding Restricted Stock
     Award or any Deferred Stock Award beyond the minimum restriction periods
     set forth in Section 6(e) and Section 7(d), respectively, nor shall the
     Administrator accelerate or amend the aggregate period over which any
     Performance Share Award is measured to less than one (1) year;"

3. The first sentence of Section 5(a)(i) is hereby amended by deleting the
phrase "(other than options granted in lieu of cash compensation)."

4. Section 7(d) is hereby deleted in its entirety and replaced with the
following:

     "Restrictions. Deferred Stock Awards vesting upon the attainment of
     performance goals or objectives shall vest after a restriction period of
     not less than one (1) year. All other Deferred Stock Awards shall vest
     after a restriction period of not less than three (3) years.

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     A Deferred Stock Award may not be sold, assigned, transferred, pledged or
     otherwise encumbered or disposed of during the deferral period."

5. Section 8(a) is hereby amended by adding the following sentence to the end of
the current provision:

     "The aggregate number of shares of Stock issuable pursuant to this Section
     8 is limited to ten percent (10%) of the maximum number of shares of Stock
     reserved and available for issuance under the Plan pursuant to Section
     3(a), as amended."

6. Section 9(a) is hereby amended by deleting the last sentence of the current
provision and replacing it with the following sentence:

     "The Administrator in its sole discretion shall determine whether and to
     whom Performance Share Awards shall be made, the performance goals, the
     periods during which performance is to be measured (which in the aggregate
     shall not be less than one (1) year), and all other limitations and
     conditions."

7. Section 9(e) entitled "Acceleration, Waiver, Etc." is hereby deleted in its
entirety.

8. Section 13 is hereby amended by deleting the first sentence of the current
provision and replacing with the following sentence:

     "Subject to requirements of law or any stock exchange or other similar
     rules which would require a vote of the Company's shareholders, the Board
     may, at any time, amend or discontinue the Plan and the Administrator may,
     at any time, amend or cancel any outstanding Award for the purpose of
     satisfying changes in law or for any other lawful purpose, but no such
     action shall adversely affect rights under any outstanding Award without
     the holder's consent."

9. Section 16(a) is hereby amended by adding the following paragraph directly
after the last paragraph of the current provision:

     "No Award under the Plan shall be a nonqualified deferred compensation
     plan, as defined in Code Section 409A, unless such Award meets in form and
     in operation the requirements of Code Section 409A(a) (2), (3), and (4)."

10. Except as herein expressly amended, the provisions of the Plan shall remain
in full force and effect.

AS APPROVED BY THE BOARD OF DIRECTORS: November 7, 2006