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Exhibit 10.1    
    


        NEITHER THIS WARRANT NOR THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. NO SALE OR
DISPOSITION MAY BE EFFECTED EXCEPT IN COMPLIANCE WITH RULE 144 UNDER SAID ACT OR WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL FOR THE HOLDER OR RECEIPT OF A
NO-ACTION LETTER FROM THE SECURITIES AND EXCHANGE COMMISSION, IN EACH CASE SATISFACTORY TO THE COMPANY, THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE ACT.  



        WARRANT TO PURCHASE 77,960 SHARES OF SERIES B PREFERRED STOCK  


        June 16, 2006  


        THIS CERTIFIES THAT, for value received, General Electric Capital
Corporation ("Holder") is entitled to subscribe for and purchase Seventy-Seven Thousand Nine Hundred Sixty (77,960) shares of the fully paid and nonassessable Series B
Preferred Stock (the "Shares" or the "Preferred Stock") of Helicos BioSciences Corporation, a Delaware corporation (the "Company"), at the Warrant Price
(as hereinafter defined), subject to the provisions and upon the terms and conditions hereinafter set forth. As used herein, the term "Series B Preferred Stock" shall mean the Company's
presently authorized Series B Convertible Preferred Stock and any stock into which such Series B Preferred Stock may hereafter be converted or exchanged. 


        1.    Warrant Price.    The Warrant Price shall initially be One and 29/100 dollars ($1.29) per share, subject to
adjustment as provided in Section 7 below. 


        2.    Conditions to Exercise.    The purchase right represented by this Warrant may be exercised at any time, or from
time to time, in whole or in part during the term commencing on the date hereof and ending on the earliest to occur of (i) 5:00 P.M. Pacific time on the seventh anniversary of the date
of this Warrant, or (ii) two (2) years after the effective date of an Initial Public Offering of Company's Common Stock on the Nasdaq National Market or another national stock exchange
in the United States. 


        3.    Method of Exercise; Payment; Issuance of Shares; Issuance of New Warrant.    



        (a)    Cash Exercise.    Subject to Section 2 hereof, the purchase right represented by this Warrant may be
exercised by the Holder hereof, in whole or in part, by the surrender of this Warrant (with a duly executed Notice of Exercise in the form attached hereto) at the principal office of the Company (as
set forth in Section 18 below) and by payment to the Company, by check, of an amount equal to the then applicable Warrant Price per share multiplied by the number of shares then being
purchased. In the event of any exercise of the rights represented by this Warrant, certificates for the shares of stock so purchased shall be in the name of, and delivered to, the Holder hereof, or as
such Holder may direct (subject to the terms of transfer contained herein and upon payment by such Holder hereof of any applicable transfer taxes). Such delivery shall be made within 30 days
after exercise of the Warrant and at the Company's expense and, unless this Warrant has been fully exercised or expired, a new Warrant having terms and conditions substantially identical to this
Warrant and representing the portion of the Shares, if any, with respect to which this Warrant shall not have been exercised, shall also be issued to the Holder hereof within 30 days after
exercise of the Warrant. 


        (b)    Net Issue Exercise.    Holder may also elect to receive shares equal to the value of this Warrant (or of any
portion thereof remaining unexercised) by surrender of this Warrant at the principal office of the Company together with notice of such election, in which event the Company 












shall
issue to Holder the number of shares of the Company's Preferred Stock computed using the following formula: 



	X	 	=	 	Y (A-B)
 A	 	 
	Where X	 	=	 	the number of shares of Preferred Stock to be issued to Holder.
	Y	 	=	 	the number of shares of Preferred Stock purchasable under this Warrant (at the date of such calculation).
	A	 	=	 	the Fair Market Value of one share of the Company's Preferred Stock (at the date of such calculation).
	B	 	=	 	Warrant Price (as adjusted to the date of such calculation).





        (c)    Fair Market Value.    For purposes of this Section 3, Fair Market Value of one share of the Company's
Preferred Stock shall mean: 




(i)
In the event of an exercise in connection with an Initial Public Offering, the per share Fair Market Value for the Preferred Stock shall be the Offering Price at which the underwriters initially
sell Common Stock to the public multiplied by the number of shares of Common Stock into which each share of Preferred Stock is then convertible; or 



(ii)
The average of the closing bid and asked prices of Common Stock quoted in the Over-The-Counter Market Summary, the last reported sale price quoted on the Nasdaq National
Market ("NNM") or on any exchange on which the Common Stock is listed, whichever is applicable, as published in the Western Edition of the Wall Street
Journal for the ten (10) trading days prior to the date of determination of Fair Market Value, multiplied by the number of shares of Common Stock into which each share
of Preferred Stock is then convertible; or 


(iii)
In the event of an exercise in connection with a merger, acquisition or other consolidation in which the Company is not the surviving entity, the per share Fair Market Value for the Preferred
Stock shall be the value to be received per share of Preferred Stock by all holders of the Preferred Stock in such transaction as determined by the Board of Directors; or 


(iv)
In any other instance, the per share Fair Market Value for the Preferred Stock shall be as determined in good faith by the Company's Board of Directors. 






In
the event of 3(c)(iii) or 3(c)(iv), above, the Company shall prepare a certificate, to be signed by an authorized officer of the Company, setting forth in reasonable detail the basis for and
method of determination of the per share Fair Market Value of the Preferred Stock. Such certification must be made to Holder at least ten (10) business days prior to the proposed effective date
of the merger, consolidation, sale, or other triggering event as defined in 3(c)(iii). 



        (d)    Automatic Exercise.    To the extent this Warrant is not previously exercised and the Fair Market Value of one
share of Preferred Stock (or other security issuable upon the exercise hereof) as determined in accordance with this Section 3 is greater than the Warrant Price in effect on such date, it shall
be automatically exercised in accordance with Sections 3(b) and 3(c) hereof (even if not surrendered) immediately before its expiration, involuntary termination or cancellation. 




        4.    Representations and Warranties of Holder and the Company.    



        (a)   Representations
and Warranties by Holder. The Holder represents and warrants to the Company with respect to this purchase as follows: 



        (i)    The
Holder has substantial experience in evaluating and investing in private placement transactions of securities of companies similar to the Company so that the Holder
is capable of evaluating the merits and risks of its investment in the Company and has the capacity to protect its interests. 











        (ii)   Except
for transfers to a Holder affiliate, the Holder is acquiring the Warrant and the Shares of Preferred Stock issuable upon exercise of the Warrant (collectively
the "Securities") for investment for its own account and not with a view to, or for resale in connection with, any distribution thereof. The Holder understands that the Securities have not been
registered under the Securities Act of 1933, as amended (the "Act") by reason of a specific exemption from the registration provisions of the Act which depends upon, among other things, the bona fide
nature of the investment intent as expressed herein. 


        (iii)  The
Holder acknowledges that the Securities must be held indefinitely unless subsequently registered under the Act or an exemption from such registration is available.
The Holder is aware of the provisions of Rule 144 promulgated under the Act. 


        (iv)  The
Holder is an "accredited investor" within the meaning of Regulation D promulgated under the Act. 


        (v)   The
Holder has had an opportunity to discuss the Company's business, management and financial affairs with its management and an opportunity to review the Company's
facilities. The Holder understands that such discussions, as well as the written information issued by the Company, were intended to describe the aspects of the Company's business and prospects which
the Company believes to be material but were not necessarily a thorough or exhaustive description. 




        (b)   Company
hereby represents and warrants to Holder as follows: 



        (i)    Corporate Organization and Authority.    Company (a) is a corporation duly organized, validly existing,
and in good standing in its jurisdiction of incorporation, (b) has the corporate power and authority to own and operate its properties and to carry on its business as now conducted and as
proposed to be conducted; and (c) is qualified as a foreign corporation in all jurisdictions where such qualification is required. 


        (ii)    Corporate Power.    Company has all requisite legal and corporate power and authority to execute, issue and
deliver the Warrant, to issue the Preferred Stock issuable upon exercise or conversion of the Warrant, and to carry out and perform its obligations under the Warrant and any related agreements. 



        (iii)    Authorization; Enforceability.    All corporate action on the part of Company, its officers, directors and
shareholders necessary for the authorization, execution, delivery and performance of its obligations under this Warrant and for the authorization, issuance and delivery of the Warrant and the
Preferred Stock issuable upon exercise of the Warrant has been taken and this Warrant constitutes the legally binding and valid obligation of Company enforceable in accordance with its terms. 


        (iv)    Valid Issuance of Warrant and Preferred Stock.    The Warrant has been validly issued and is free of
restrictions on transfer other than restrictions on transfer set forth herein and under applicable state and federal securities laws. The Preferred Stock issuable upon conversion of this Warrant, when
issued, sold and delivered in accordance with the terms of this Warrant for the consideration expressed herein, will be duly and validly issued, fully paid and nonassessable, and will be free of
restrictions on transfer other than restrictions on transfer under this Warrant and under applicable state and federal securities laws. 


        (v)    No Conflict with Other Instruments.    The execution, delivery, and performance of this Warrant will not result
in any violation of, be in conflict with, or constitute a default under, with or without the passage of time or the giving of notice (a) any provision of Company's Certificate of Incorporation
or by-laws; (b) any provision of any judgment, decree, or order to which Company is a party or by which it is bound or an event which results in the creation of any material lien,
charge or encumbrance upon any material assets of Company; (c) any material contract, obligation, or commitment to which Company is a party or by which it is bound; or (d) any statute,
rule, or governmental regulation applicable to Company. 














        (vi)    Capitalization.    As of recent date, the authorized capital stock of Company consists of 100,000,000 shares
of Common Stock, $0.001 par value, of which 7,744,091 were issued and outstanding, and 59,314,030 shares of Preferred Stock, $0.001 par value, of which 28,182,246 have been designated as
Series A Convertible Preferred Stock, all of which were issued and outstanding, and 31,131,784 have been designated as Series B Convertible Preferred Stock, 15,503,876 of which were
issued and outstanding. The outstanding shares have been duly authorized and validly issued (including, without limitation, issued in compliance with applicable federal and state securities laws), are
fully paid and nonassessable. Company has reserved 59,314,030 shares of Common Stock for issuance upon conversion of the Preferred Stock. Except as previously disclosed to the Holder on or prior to
the date of this Warrant, there are no outstanding warrants, options, conversion privileges, preemptive rights or other rights or agreements to purchase or otherwise acquire or issue any equity
securities or Convertible Securities of Company, nor has the issuance of any of the aforesaid rights to acquire securities of Company been authorized. 





        5.    Legends.    



        (a)   Each
certificate representing the Securities shall be endorsed with the following legend: 



THIS
SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 OR ANY STATE SECURITIES LAWS AND MAY NOT BE TRANSFERRED OR OTHERWISE DISPOSED OF UNLESS IT HAS BEEN REGISTERED UNDER SUCH ACT AND
ALL SUCH APPLICABLE LAWS OR AN EXEMPTION FROM REGISTRATION IS AVAILABLE. 




The
Company need not enter into its stock records a transfer of Securities unless the conditions specified in the foregoing legend are satisfied. The Company may also instruct its transfer agent not
to allow the transfer of any of the Shares unless the conditions specified in the foregoing legend are satisfied. 


        (b)    Removal of Legend and Transfer Restrictions.    The legend relating to the Act endorsed on a certificate
pursuant to paragraph 5(a) of this Warrant shall be removed and the Company shall issue a certificate without such legend to the Holder of the Securities if (i) the Securities are
transferred pursuant to an effective registration statement under the Act and a prospectus meeting the requirements of Section 10 of the Act or (ii) the Holder provides to the Company an
opinion of counsel for the Holder reasonably satisfactory to the Company, a no-action letter or interpretive opinion of the staff of the SEC reasonably satisfactory to the Company, or
other evidence reasonably satisfactory to the Company, to the effect that public sale, transfer or assignment of the Securities may be made without registration and without compliance with any
restriction such as Rule 144. 


        6.    Condition of Transfer or Exercise of Warrant.    It shall be a condition to any transfer or exercise of this
Warrant that at the time of such transfer or exercise, the Holder shall provide the Company with a representation in writing that the Holder or transferee is acquiring this Warrant and the shares of
Preferred Stock to be issued upon exercise for investment purposes only and not with a view to any sale or distribution, or will provide the Company with a statement of pertinent facts covering any
proposed distribution. As a further condition to any transfer of this Warrant or any or all of the shares of Preferred Stock issuable upon exercise of this Warrant, other than a transfer registered
under the Act, the Company may request a legal opinion, in form and substance satisfactory to the Company and its counsel, reciting the pertinent circumstances surrounding the proposed transfer and
stating that such transfer is exempt from the registration and prospectus delivery requirements of the Act. The Company shall not require Holder to provide an opinion of counsel if the transfer is to
an affiliate of Holder. Each certificate evidencing the shares issued upon exercise of the Warrant or upon any transfer of the shares (other than a transfer registered under the Act or any subsequent
transfer of shares so registered) shall, at the Company's option, if the Shares are not freely saleable under Rule 144(k) under the Act, contain a legend in form and substance satisfactory to
the Company and its counsel, restricting the transfer of the shares to sales 












or
other dispositions exempt from the requirements of the Act. As further condition to each transfer, at the request of the Company, the Holder shall surrender this Warrant to the Company and the
transferee shall receive and accept a Warrant, of like tenor and date, executed by the Company. Notwithstanding anything to the contrary contained herein, Holder shall not, without the prior written
consent of the Company, transfer any Shares, or any securities issued or issuable upon conversion of the Shares, to any person who is a supplier, customer or competitor of the Company at such time. 




        7.    Adjustment for Certain Events.    The number and kind of securities purchasable upon the exercise of this
Warrant and the Warrant Price shall be subject to adjustment from time to time upon the occurrence of certain events, as follows: 



        (a)    Reclassification or Merger.    In case of any reclassification or change of securities of the class issuable
upon exercise of this Warrant (other than a change in par value, or from par value to no par value, or from no par value to par value, or as a result of a subdivision or combination), or in case of
any merger of the Company with or into another corporation (other than a merger with another corporation in which the Company is the acquiring and the surviving corporation and which does not result
in any reclassification or change of outstanding securities issuable upon exercise of this Warrant),
or in case of any sale of all or substantially all of the assets of the Company, the Company, or such successor or purchasing corporation, as the case may be, shall duly execute and deliver to the
Holder a new Warrant (in form and substance satisfactory to the Holder of this Warrant), or the Company shall make appropriate provision without the issuance of a new Warrant, so that the Holder shall
have the right to receive, at a total purchase price not to exceed that payable upon the exercise of the unexercised portion of this Warrant, and in lieu of the shares of Preferred Stock theretofore
issuable upon exercise of this Warrant, the kind and amount of shares of stock, other securities, money and property receivable upon such reclassification, change, merger or sale by a Holder of the
number of shares of Preferred Stock then purchasable under this Warrant, or in the case of such a merger or sale in which the consideration paid consists all or in part of assets other than securities
of the successor or purchasing corporation, at the option of the Holder, the securities of the successor or purchasing corporation having a value at the time of the transaction equivalent to the value
of the Preferred Stock purchasable upon exercise of this Warrant at the time of the transaction. Any new Warrant shall provide for adjustments that shall be as nearly equivalent as may be practicable
to the adjustments provided for in this Section 7. The provisions of this subparagraph (a) shall similarly apply to successive reclassifications, changes, mergers and transfers. 


        (b)    Subdivision or Combination of Shares.    If the Company at any time while this Warrant remains outstanding and
unexpired shall subdivide or combine its outstanding shares of Preferred Stock, the Warrant Price shall be proportionately decreased and the number of Shares issuable hereunder shall be
proportionately increased in the case of a subdivision and the Warrant Price shall be proportionately increased and the number of Shares issuable hereunder shall be proportionately decreased in the
case of a combination. 


        (c)    Stock Dividends and Other Distributions.    If the Company at any time while this Warrant is outstanding and
unexpired shall (i) pay a dividend with respect to Preferred Stock payable in Preferred Stock, then the Warrant Price shall be adjusted, from and after the date of determination of shareholders
entitled to receive such dividend or distribution, to that price determined by multiplying the Warrant Price in effect immediately prior to such date of determination by a fraction (A) the
numerator of which shall be the total number of shares of Preferred Stock outstanding immediately prior to such dividend or distribution, and (B) the denominator of which shall be the total
number of shares of Preferred Stock outstanding immediately after such dividend or distribution; or (ii) make any other distribution with respect to Preferred Stock (except any distribution
specifically provided for in Sections 7(a) and 7(b)), then, in each such case, provision shall be made by the Company such that the Holder of this Warrant shall receive upon exercise of this Warrant a
proportionate share of any such dividend or distribution as though it were the Holder of the Preferred Stock (or Common Stock issuable upon 












conversion
thereof) as of the record date fixed for the determination of the shareholders of the Company entitled to receive such dividend or distribution. 




        8.    Notice of Adjustments.    Whenever any Warrant Price or the kind or number of securities issuable under this
Warrant shall be adjusted pursuant to Section 7 hereof, the Company shall prepare a certificate signed by an officer of the Company setting forth, in reasonable detail, the event requiring the
adjustment, the amount of the adjustment, the method by which such adjustment was calculated, and
the Warrant Price and number or kind of shares issuable upon exercise of the Warrant after giving effect to such adjustment, and shall cause copies of such certificate to be mailed (by certified or
registered mail, return receipt required, postage prepaid) within thirty (30) days of such adjustment to the Holder of this Warrant as set forth in Section 18 hereof. 



        9.    Transferability of Warrant.    This Warrant is transferable on the books of the Company at its principal office
by the registered Holder hereof upon surrender of this Warrant properly endorsed, subject to compliance with Section 6 and applicable federal and state securities laws. The Company shall issue
and deliver to the transferee a new Warrant representing the Warrant so transferred. Upon any partial transfer, the Company will issue and deliver to Holder a new Warrant with respect to the Warrant
not so transferred. Notwithstanding anything contained in this Warrant to the contrary, Holder shall not have any right to transfer any portion of this Warrant to any supplier, customer or competitor
of the Company. 


        10.    Registration Rights.    Subject to this Section 10, the Company grants registration rights to the Holder
of this Warrant for any Common Stock of the Company obtained upon conversion of the Preferred Stock in parity to the registration rights granted to other holders of the Preferred Stock. Upon the
exercise of the Holder's right to purchase any portion of the Shares under this Warrant, the Holder shall become a subject to the provisions of that certain Amended and Restated Investor Rights
Agreement, dated as of March 1, 2006, as may be amended from time to time (other than Sections 12 and 13 thereof), as an Investor (as defined therein) by signing a counterpart signature page to
the Investor Rights Agreement and shall bound by all of the obligations of an Investor under the Investor Rights Agreement. 


        11.    No Fractional Shares.    No fractional share of Preferred Stock will be issued in connection with any exercise
hereunder, but in lieu of such fractional share the Company shall make a cash payment therefor upon the basis of the Warrant Price then in effect. 



        12.    Charges, Taxes and Expenses.    Issuance of certificates for shares of Preferred Stock upon the exercise of
this Warrant shall be made without charge to the Holder for any United States or state of the United States documentary stamp tax or other incidental expense with respect to the issuance of such
certificate, all of which taxes and expenses shall be paid by the Company, and such certificates shall be issued in the name of the Holder. 


        13.    No Shareholder Rights Until Exercise.    This Warrant does not entitle the Holder hereof to any voting rights
or other rights as a shareholder of the Company prior to the exercise hereof. 



        14.    Registry of Warrant.    The Company shall maintain a registry showing the name and address of the registered
Holder of this Warrant. This Warrant may be surrendered for exchange or exercise, in accordance with its terms, at such office or agency of the Company, and the Company and Holder shall be entitled to
rely in all respects, prior to written notice to the contrary, upon such registry. 


        15.    Loss, Theft, Destruction or Mutilation of Warrant.    Upon receipt by the Company of evidence reasonably
satisfactory to it of the loss, theft, destruction or mutilation of this Warrant, and, in the case of loss, theft, or destruction, of indemnity reasonably satisfactory to it, and, if mutilated, upon
surrender and cancellation of this Warrant, the Company will execute and deliver a new Warrant, having terms and conditions substantially identical to this Warrant, in lieu hereof. 


        16.    Miscellaneous.    



        (a)    Issue Date.    The provisions of this Warrant shall be construed and shall be given effect in all respect as if
it had been issued and delivered by the Company on the date hereof. 









        (b)    Successors.    This Warrant shall be binding upon any successors or assigns of the Company. 



        (c)    Governing Law.    This Warrant shall be governed by and construed in accordance with the laws of the State of
Delaware. 


        (d)    Headings.    The headings used in this Warrant are used for convenience only and are not to be considered in
construing or interpreting this Warrant. 


        (e)    Saturdays, Sundays, Holidays.    If the last or appointed day for the taking of any action or the expiration of
any right required or granted herein shall be a Saturday or a Sunday or shall be a legal holiday in the State of Delaware, then such action may be taken or such right may be exercised on the next
succeeding day not a legal holiday. 


        (f)    Waiver of Jury Trial.    Each of the parties hereto hereby waives to the fullest extent permitted by applicable
law, any right it may have to a trial by jury in respect of any litigation directly or indirectly arising out of, under or in connection with this Warrant or the Preferred Shares. 


        (g)    Attorney's Fees.    In the event of any dispute between the parties concerning the terms and provisions of this
Warrant, the party prevailing in such dispute shall be entitled to collect from the other party all costs incurred in such dispute, including reasonable attorney's fees. 


        (h)    Waiver.    This Warrant and any term hereof may be changed, waived, discharged or terminated only by an
instrument in writing signed by the party against which enforcement of such change, waiver, discharge or termination is sought. 




        17.    No Impairment.    The Company will not, by amendment of its Certificate of Incorporation or any other voluntary
action, avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will at all times in good faith assist in the carrying out of all such terms and in the taking of
all such action as may be necessary or appropriate in order to protect the rights of the Holder hereof against impairment. 


        18.    Addresses.    Any notice required or permitted hereunder shall be in writing and shall be mailed by overnight
courier, registered or certified mail, return receipt required, and postage prepaid, or otherwise delivered by hand or by messenger, addressed as set forth below, or at such other address as the
Company or the Holder hereof shall have furnished to the other party. 



	 
	 	 

	If to the Company:	 	Helicos BioSciences Corporation

One Kendall Square, Building 200

Cambridge, MA 02139

Attn: General Counsel
	

If to the Holder:	
 	
General Electric Capital Corporation

83 Wooster Heights Road

Danbury, CT 06810

Attn: Credit Manager-Life Science Finance






        19.    Qualifying Public Offering.    If the Company shall effect a firm commitment underwritten public offering of
shares of Common Stock which results in the conversion of the Preferred Stock into Common Stock pursuant to the Company's Certificate of Incorporation in effect immediately prior to such offering,
then, effective upon such conversion, this Warrant shall change from the right to purchase shares of Preferred Stock to the right to purchase shares of Common Stock, and the Holder shall thereupon
have the right to purchase, at a total price equal to that payable upon the exercise of this Warrant in full, the number of shares of Common Stock which would have been receivable by the Holder upon
the exercise of this Warrant for shares of Preferred Stock immediately prior to such conversion of such shares of Preferred Stock into shares of Common Stock, and in such event appropriate provisions
shall be made with respect to the rights and interest of the Holder to the end 










that
the provisions hereof (including, without limitation, the provisions for the adjustment of the Purchase Price and of the number of shares purchasable upon exercise of this Warrant and the
provisions relating to the net issue election) shall thereafter be applicable to any shares of Common Stock deliverable upon the exercise hereof. 



        IN
WITNESS WHEREOF, Helicos BioSciences Corporation has caused this Warrant to be executed by its officers thereunto duly authorized. 



	 
	 	 
	 	 

	Dated as of June 16, 2006.	 	By:	 	/s/ Stanley N. Lapidus

	

 	
 	

Name:	
 	

Stanley N. Lapidus

	

 	
 	

Title:	
 	

President & CEO














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Exhibit 10.1