Exhibit  31.1





CERTIFICATION





I, Leonard Osser, certify that:





| | 1. | I have reviewed this    quarterly report on Form 10-QSB of Milestone Scientific, Inc. (the    registrant).                                                                                                                                                                                                                                   
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| | 2. | Based on my knowledge,    this quarterly report does not contain any untrue statement of a material    fact or omit to state a material fact necessary to make the statements made,    in light of the circumstances under which such statements were made, not    misleading with respect to the period covered by this quarterly report;     
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| | 3. | Based on my knowledge, the    financial statements, and other financial information included in this    quarterly report, fairly present in all material respects the financial    condition, results of operations and cash flows of the small business issuer    as of, and for, the periods presented in this quarterly report;             
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| | 4. | The small business    issuers other certifying officer and I are responsible for establishing and    maintaining disclosure controls and procedures (as defined in Exchange Act    Rules 13a-15(e) and 15d-15(e) for the small business issuer and have:                                                                                      
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| |    | b)                                                                                                                                                                                                                                                                                                                                             
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| |    | c)                                                                                                                                                                                                                                                                                                                                             
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| | 5. | The small    business issuers other certifying officer(s) and I have disclosed, based on    our most recent evaluation of internal control over financial reporting, to the small business    issuers auditors and the audit committee of the small business issuers    board of directors (or persons performing the equivalent functions):
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| |    | a)                                                                                                                                                                                                                                                                                                                                             
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| |    | b)                                                                                                                                                                                                                                                                                                                                             




Date: November 14, 2005


| | /s/ Leonard Osser                      
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| |                                        
| | Leonard Osser                          
| | Chairman and Chief    Executive Officer




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