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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549





FORM 10-Q





(Mark One)

|x | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ---------------------------------------------------------------------------------------

For the quarterly period ended April 30, 2009

or



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from              to

Commission File Number 001-15167





BIOPURE CORPORATION

(Exact name of registrant as specified in its charter)







|                                           |  |                                     
|------------------------------------------ |  | ------------------------------------
|Delaware                                   |  | 04-2836871                          
|(State of Incorporation)                   |  | (IRS Employer Identification Number)
|                                           | 
|11 Hurley Street, Cambridge, Massachusetts |  | 02141                               
|(Address of principal executive offices)   |  | (Zip Code)                          

(617) 234-6500

(Registrants telephone number)





Indicate by check mark whether the registrant
(1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and
(2) has been subject to such filing requirements for the past 90 days.    x  Yes     ̈  No

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be
submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).     ̈  Yes     ̈  No

Indicate by check mark whether the
registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See definitions of large accelerated filer, accelerated filer and smaller reporting company
in Rule 12b-2 of the Exchange Act.



|                        |  |                                                  |  |                           |  |  
|----------------------- |  | ------------------------------------------------ |  | ------------------------- |  | -
|Large accelerated filer |  |  ̈                                                |  | Accelerated filer         |  |  ̈
|                        |  |                                                  | 
|Non-accelerated filer   |  |  ̈  (Do not check if a smaller reporting company) |  | Smaller reporting company |  | x

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange
Act)      ̈  Yes    x  No

The number of shares outstanding of each of the issuers classes of common stock as of June 8, 2009 was:

Class A Common Stock,
$.01 par value: 39,709,015

Class B Common Stock, $1.00 par value: 117.7









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##### Table of Contents

BIOPURE CORPORATION

INDEX TO FORM 10-Q



|                                                                                                           |  |     
|---------------------------------------------------------------------------------------------------------- |  | ----
|                                                                                                           |  | Page
|Part IFinancial Information:                                                                              |  |     
|Item 1Financial Statements (Unaudited)                                                                    |  |     
|Condensed Consolidated Balance Sheets at April 30, 2009 and October 31, 2008                               |  | 3   
|Condensed Consolidated Statements of Operations for the six months ended April 30, 2009 and April 30 2008  |  | 4   
|Condensed Consolidated Statements of Cash Flows for the six months ended April 30, 2009 and April 30, 2008 |  | 5   
|Notes to Condensed Consolidated Financial Statements                                                       |  | 6   
|Item 2Managements Discussion and Analysis of Financial Condition and Results of
Operations               |  | 12  
|Item 3Quantitative and Qualitative Disclosure about Market Risk                                           |  | 14  
|Item 4Controls and Procedures                                                                             |  | 14  
|Part IIOther Information:                                                                                 |  |     
|Item 1Legal Proceedings                                                                                   |  | 16  
|Item 1ARisk Factors                                                                                       |  | 16  
|Item 2Unregistered Sales of Equity Securities and Use of Proceeds                                         |  | 17  
|Item 3Defaults Upon Senior Securities                                                                     |  | 17  
|Item 4Submission of Matters to a Vote of Security Holders                                                 |  | 17  
|Item 5Other Information                                                                                   |  | 17  
|Item 6Exhibits                                                                                            |  | 17  
|Signatures                                                                                                 |  | 18  
|Exhibit Index                                                                                              |  | 19  

Biopure®, Hemopure®, and Oxyglobin® are registered trademarks of Biopure Corporation.



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##### Table of Contents

BIOPURE CORPORATION

Condensed Consolidated Balance Sheets

(In thousands, except share and per share data)

(Unaudited)



|                                                                                                                                         |  |               |          |   |                 |   |          |  
|---------------------------------------------------------------------------------------------------------------------------------------- |  | ------------- | -------- | - | --------------- | - | -------- | -
|                                                                                                                                         |  | April 30,2009 |          |   | October 31,2008 |  
|Assets:                                                                                                                                  |  |               |          |   |                 |   |          |  
|Current assets:                                                                                                                          |  |               |          |   |                 |   |          |  
|Cash and cash equivalents                                                                                                                |  | $             | 245      |   |                 | $ | 1,095    |  
|Accounts receivable, net                                                                                                                 |  |               | 359      |   |                 |   | 426      |  
|Inventories                                                                                                                              |  |               | 983      |   |                 |   | 1,995    |  
|Prepaid expenses and other current assets                                                                                                |  |               | 491      |   |                 |   | 740      |  
|                                                                                                                                         |  |               |          |   |                 |   |          |  
|Total current assets                                                                                                                     |  |               | 2,078    |   |                 |   | 4,256    |  
|Property, plant and equipment, net                                                                                                       |  |               | 2,553    |   |                 |   | 5,129    |  
|Other assets                                                                                                                             |  |               | 445      |   |                 |   | 592      |  
|                                                                                                                                         |  |               |          |   |                 |   |          |  
|Total assets                                                                                                                             |  | $             | 5,076    |   |                 | $ | 9,977    |  
|                                                                                                                                         |  |               |          |   |                 |   |          |  
|                                                                                                                                         |  |              
|Liabilities and stockholders equity:                                                                                                    |  |               |          |   |                 |   |          |  
|Current liabilities:                                                                                                                     |  |               |          |   |                 |   |          |  
|Accounts payable                                                                                                                         |  | $             | 446      |   |                 | $ | 591      |  
|Accrued expenses                                                                                                                         |  |               | 1,071    |   |                 |   | 1,786    |  
|Deferred revenue                                                                                                                         |  |               | 1,212    |   |                 |   | 35       |  
|                                                                                                                                         |  |               |          |   |                 |   |          |  
|Total current liabilities                                                                                                                |  |               | 2,729    |   |                 |   | 2,412    |  
|                                                                                                                                         |  |               |          |   |                 |   |          |  
|Deferred revenue, net of current portion                                                                                                 |  |               |         |   |                 |   | 1,177    |  
|                                                                                                                                         |  |               |          |   |                 |   |          |  
|                                                                                                                                         |  |              
|Commitments and contingencies, Note 6                                                                                                    |  |               |          |   |                 |   |          |  
|Stockholders equity:                                                                                                                    |  |               |          |   |                 |   |          |  
|Preferred stock, $0.01 par value, 30,000,000 shares authorized, no shares outstanding                                                    |  |               |         |   |                 |   |         |  
|Common stock:                                                                                                                            |  |               |          |   |                 |   |          |  
|Class A, $0.01 par value, 200,000,000 shares authorized, 39,709,015 shares issued and outstanding at April 30, 2009 and
October 31, 2008 |  |               | 397      |   |                 |   | 397      |  
|Class B, $1.00 par value, 179 shares authorized, 117.7 shares outstanding at April 30, 2009 and October 31, 2008                         |  |               |         |   |                 |   |         |  
|Capital in excess of par value                                                                                                           |  |               | 563,719  |   |                 |   | 563,613  |  
|Contributed capital                                                                                                                      |  |               | 24,574   |   |                 |   | 24,574   |  
|Accumulated other comprehensive loss                                                                                                     |  |               | (167     | ) |                 |   | (169     | )
|Accumulated deficit                                                                                                                      |  |               | (586,176 | ) |                 |   | (582,027 | )
|                                                                                                                                         |  |               |          |   |                 |   |          |  
|Total stockholders equity                                                                                                               |  |               | 2,347    |   |                 |   | 6,388    |  
|                                                                                                                                         |  |               |          |   |                 |   |          |  
|Total liabilities and stockholders equity                                                                                               |  | $             | 5,076    |   |                 | $ | 9,977    |  
|                                                                                                                                         |  |               |          |   |                 |   |          |  

See accompanying notes



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BIOPURE CORPORATION

Condensed Consolidated Statements of Operations

(In thousands, except share and per
share data)

(Unaudited)



|                                                                                      |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  
|------------------------------------------------------------------------------------- |  | ------------------ | ---------- | - | ---------------- | - | ---------- | -------------- |  | - | -------------- | - |  | - | ---------- | -
|                                                                                      |  | Three Months Ended |            |   | Six Months Ended |  
|                                                                                      |  | April 30, 2009     |            |   | April 30, 2008   |   |            | April 30, 2009 |  |   | April 30, 2008 |  
|Revenues:                                                                             |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  
|Product revenue                                                                       |  | $                  | 13         |   |                  | $ | 866        |                |  | $ | 878            |   |  | $ | 1,343      |  
|Research and development revenue                                                      |  |                    | 334        |   |                  |   | 36         |                |  |   | 627            |   |  |   | 132        |  
|                                                                                      |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  
|Total revenues                                                                        |  |                    | 347        |   |                  |   | 902        |                |  |   | 1,505          |   |  |   | 1,475      |  
|Cost of product revenues                                                              |  |                    | 9          |   |                  |   | 1,813      |                |  |   | 1,009          |   |  |   | 4,601      |  
|                                                                                      |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  
|Gross profit (loss)                                                                   |  |                    | 338        |   |                  |   | (911       | )              |  |   | 496            |   |  |   | (3,126     | )
|                                                                                      |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  
|Operating expenses:                                                                   |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  
|Research and development                                                              |  |                    | 208        |   |                  |   | 1,756      |                |  |   | 1,328          |   |  |   | 3,243      |  
|Sales and marketing                                                                   |  |                    | 54         |   |                  |   | 448        |                |  |   | 150            |   |  |   | 728        |  
|General and administrative                                                            |  |                    | 1,906      |   |                  |   | 1,947      |                |  |   | 3,234          |   |  |   | 3,948      |  
|                                                                                      |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  
|Total operating expenses                                                              |  |                    | 2,168      |   |                  |   | 4,151      |                |  |   | 4,712          |   |  |   | 7,919      |  
|                                                                                      |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  
|Loss from operations                                                                  |  |                    | (1,830     | ) |                  |   | (5,062     | )              |  |   | (4,216         | ) |  |   | (11,045    | )
|Other income, net                                                                     |  |                    | 38         |   |                  |   | 201        |                |  |   | 67             |   |  |   | 377        |  
|                                                                                      |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  
|Net loss                                                                              |  | $                  | (1,792     | ) |                  | $ | (4,861     | )              |  | $ | (4,149         | ) |  | $ | (10,668    | )
|                                                                                      |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  
|Per share data:                                                                       |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  
|Basic and diluted net loss per common share                                           |  | $                  | (0.05      | ) |                  | $ | (0.14      | )              |  | $ | (0.10          | ) |  | $ | (0.31      | )
|                                                                                      |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  
|Weighted-average shares used in computing basic and diluted net loss per common share |  |                    | 39,709,015 |   |                  |   | 34,971,087 |                |  |   | 39,709,015     |   |  |   | 34,439,865 |  
|                                                                                      |  |                    |            |   |                  |   |            |                |  |   |                |   |  |   |            |  

See accompanying notes



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BIOPURE CORPORATION

Condensed Consolidated Statements of Cash Flows

(In thousands)

(Unaudited)



|                                                                            |  |                  |        |   |                |   |         |  
|--------------------------------------------------------------------------- |  | ---------------- | ------ | - | -------------- | - | ------- | -
|                                                                            |  | Six Months Ended |       
|                                                                            |  | April 30, 2009   |        |   | April 30, 2008 |  
|Operating activities:                                                       |  |                  |        |   |                |   |         |  
|Net loss                                                                    |  | $                | (4,149 | ) |                | $ | (10,668 | )
|Adjustments to reconcile net loss to net cash used in operating activities: |  |                  |        |   |                |   |         |  
|Depreciation and amortization                                               |  |                  | 1,334  |   |                |   | 869     |  
|Stock-based compensation                                                    |  |                  | 106    |   |                |   | 353     |  
|(Gain) loss on disposal of fixed assets                                     |  |                  | (12    | ) |                |   | 32      |  
|Accretion of restructuring charges                                          |  |                  |       |   |                |   | 1       |  
|Amortization of deferred gain on sale-leaseback                             |  |                  | (2     | ) |                |   |        |  
|Changes in assets and liabilities:                                          |  |                  |        |   |                |   |         |  
|Accounts receivable                                                         |  |                  | 67     |   |                |   | (146    | )
|Inventories                                                                 |  |                  | 1,012  |   |                |   | (1,037  | )
|Prepaid expenses and other current assets                                   |  |                  | 409    |   |                |   | 85      |  
|Other assets                                                                |  |                  | 119    |   |                |   | 19      |  
|Accounts payable                                                            |  |                  | (145   | ) |                |   | (396    | )
|Accrued expenses                                                            |  |                  | (754   | ) |                |   | (42     | )
|Restructuring charges                                                       |  |                  |       |   |                |   | (45     | )
|Other current liabilities                                                   |  |                  |       |   |                |   | 57      |  
|Deferred revenue                                                            |  |                  |       |   |                |   | (41     | )
|                                                                            |  |                  |        |   |                |   |         |  
|Net cash used in operating activities                                       |  |                  | (2,015 | ) |                |   | (10,959 | )
|                                                                            |  |                  |        |   |                |   |         |  
|Investing activities:                                                       |  |                  |        |   |                |   |         |  
|Purchases of property, plant and equipment                                  |  |                  |       |   |                |   | (120    | )
|Net proceeds from sales of assets                                           |  |                  | 1,163  |   |                |   |        |  
|                                                                            |  |                  |        |   |                |   |         |  
|Net cash provided by (used in) investing activities                         |  |                  | 1,163  |   |                |   | (120    | )
|                                                                            |  |                  |        |   |                |   |         |  
|Financing activities:                                                       |  |                  |        |   |                |   |         |  
|Net proceeds from sale of common stock and warrants                         |  |                  |       |   |                |   | 14,872  |  
|                                                                            |  |                  |        |   |                |   |         |  
|Net cash provided by financing activities                                   |  |                  |       |   |                |   | 14,872  |  
|                                                                            |  |                  |        |   |                |   |         |  
|Net (decrease) increase in cash and cash equivalents                        |  |                  | (852   | ) |                |   | 3,793   |  
|Effect of exchange rate changes on cash and cash equivalents                |  |                  | 2      |   |                |   | (18     | )
|Cash and cash equivalents at beginning of period                            |  |                  | 1,095  |   |                |   | 1,910   |  
|                                                                            |  |                  |        |   |                |   |         |  
|Cash and cash equivalents at end of period                                  |  | $                | 245    |   |                | $ | 5,685   |  
|                                                                            |  |                  |        |   |                |   |         |  
|                                                                            |  |                 
|Supplementary information:                                                  |  |                  |        |   |                |   |         |  
|Interest paid                                                               |  | $                |       |   |                | $ |        |  
|                                                                            |  |                  |        |   |                |   |         |  
|Income taxes paid                                                           |  | $                |       |   |                | $ |        |  
|                                                                            |  |                  |        |   |                |   |         |  

See accompanying notes



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BIOPURE CORPORATION

Notes to Condensed Consolidated Financial Statements

April 30, 2009

(Unaudited)



|1. | Basis of Presentation
|-- | ---------------------

The accompanying unaudited condensed consolidated
financial statements have been prepared in accordance with accounting principles generally accepted in the United States for interim financial information and pursuant to the rules and regulations of the Securities and Exchange Commission (SEC).
Accordingly, they do not include all of the information and footnotes required by accounting principles generally accepted in the United States for complete financial statements. In the opinion of management, all adjustments (consisting of normal
recurring adjustments) considered necessary for a fair presentation have been included. Operating results for the six month period ended April 30, 2009 are not necessarily indicative of the results that may be expected for any other period or
for the year ending October 31, 2009.

The accompanying consolidated financial statements include the accounts of the Company and its wholly-owned
subsidiaries, Biopure Netherlands, BV, Biopure South Africa, Pty, Ltd., Reperfusion Systems Incorporated, DeNovo Technologies Corporation and Biopure Overseas Holding Company, and NeuroBlok Incorporated, a 60% owned subsidiary. All intercompany
accounts and transactions have been eliminated in consolidation.

These financial statements should be read in conjunction with the audited consolidated
financial statements and notes thereto included in the Companys Annual Report on Form 10-K/A for the fiscal year ended October 31, 2008, filed with the SEC on March 3, 2009.

The Company has financed operations from inception primarily through sales of equity securities and development and license agreement payments. The Company has not been
profitable since inception and had an accumulated deficit of $586 million at April 30, 2009. In June 2008, the Company signed an agreement with purchasers for a private placement of its class A common stock and warrants for up to $2.3
million assuming no exercise of the warrants. Under the terms of the agreement the Company sold to accredited investors in monthly tranches 4,737,928 shares of its common stock and warrants to acquire an additional 4,737,928 shares. The price for
one share and one warrant was $0.3377, and the exercise price of each warrant is $0.45. The warrants have terms of five years, become exercisable six months after the applicable tranche closing date, and are callable by Biopure after the initial
exercise date provided that the weighted average price of Biopures common stock for ten consecutive days is over $0.675. Under this agreement, the Company raised a total of $1.5 million.

The Company expects current assets and product sales to be sufficient to fund operations through July 31, 2009 under the current operating plan. The current
operating plan anticipates a possible sale of all or substantially all of the Companys assets by that date. The Company would require significant additional funding to remain a going concern and to fund operations until such time, if ever, as
it might become profitable. The Company has been unable to procure such additional financing despite efforts since 2008, including engagement of an investment banker in 2008 and obtaining limited financing from existing investors in 2008. It is
actively seeking to complete a more fundamental transaction, such as a sale of the company, although there is no assurance that it will succeed in completing a transaction. In March 2009, the Company sold its manufacturing facility and land in
Pennsylvania and entered into a lease for that facility for consideration of $1.4 million, of which $1.2 million was in the form of cash and the balance as rent abatements.

The Company may not continue to qualify for continued listing on the Nasdaq Capital Market. The NASDAQ Market Place Rules require listed companies to maintain, among other things, a minimum daily closing bid price per
share of $1.00. The Company is out of compliance with the $1.00 minimum bid price requirement for continued inclusion of its class A common stock in the Nasdaq Stock Market. The Company would have received a delisting notice in December 2008, had
Nasdaq not suspended enforcement of this requirement because of turmoil in the marketplace. The Company may be unable to meet the listing requirements of the Nasdaq Capital Market in the future. The Company has been out of compliance since
December 14, 2007 and estimates, based on the most recent notice it has received from Nasdaq, that it now has until September 12, 2009 to regain compliance by having the bid price of its Class A common stock close at $1.00 per share
or more for at least 10 consecutive business days. If the Company does not regain compliance with the minimum bid price rule, Nasdaq will provide written notification that the Companys Class A common stock will be delisted. These
conditions raise substantial doubt about the Companys ability to continue as a going concern.

Without sufficient capital to fund its operations the
Company will be unable to continue as a going concern. The financial statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classification of liabilities
or any other adjustments that might be necessary when the Company is unable to continue as a going concern.



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BIOPURE CORPORATION

Notes to Condensed Consolidated Financial Statements

April 30, 2009

(Unaudited)

Comprehensive Loss

The Companys comprehensive loss includes accumulated foreign currency translation adjustments. The comprehensive loss was as follows (in thousands):



|                                                   |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|-------------------------------------------------- |  | ------------------ | ------ | - | ---------------- | - | ------ | -------------- |  | - | -------------- | - |  | - | ------- | -
|                                                   |  | Three Months Ended |        |   | Six Months Ended |  
|                                                   |  | April 30, 2009     |        |   | April 30, 2008   |   |        | April 30, 2009 |  |   | April 30, 2008 |  
|Net loss                                           |  | $                  | (1,792 | ) |                  | $ | (4,861 | )              |  | $ | (4,149         | ) |  | $ | (10,668 | )
|Changes in foreign currency translation adjustment |  |                    | 13     |   |                  |   | 9      |                |  |   | 2              |   |  |   | (18     | )
|                                                   |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|Comprehensive loss                                 |  | $                  | (1,779 | ) |                  | $ | (4,852 | )              |  | $ | (4,147         | ) |  | $ | (10,686 | )
|                                                   |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  



|2. | Net Loss per Share
|-- | ------------------

Basic net loss per common share is computed based on
the weighted-average number of common shares outstanding during the period. Diluted net loss per common share is computed based on the weighted-average number of common shares outstanding during the period, adjusted for the dilutive effect of the
Companys common stock equivalents, including the maximum number of shares issuable upon the conversion of class B common stock outstanding and the exercise of class A common stock options and warrants. The dilutive effect of stock options and
warrants is determined based on the treasury stock method using the average market price of the class A common stock for the period. However, basic and diluted net loss per common share are presented as the same for all periods presented, as the
Company had losses for all periods presented, so the effect of class B common stock, options and warrants for class A common stock is anti-dilutive. Consequently, dilutive weighted-average shares outstanding do not include all common-equivalent
shares outstanding during the three and six months ended April 30, 2009 and 2008, as their effect would have been anti-dilutive.



|3. | Stock Based Compensation
|-- | ------------------------

As of April 30, 2009, the Company had two
share-based compensation plans, the Biopure Corporation 2008 Incentive Plan (the 2008 Plan) and the 2002 Biopure Corporation Omnibus Securities and Incentive Plan (the 2002 Plan). The Plans, as amended, which are both
shareholder approved, permit the grant of options to the Companys employees, consultants and directors for up to 8,343,328 shares of common stock. Option awards are generally granted with an exercise price equal to the market price of the
Companys stock at the date of grant. Typically, granted options vest in annual increments over four years and may be exercised within seven or ten years of the date of grant. Options to the non-employee members of the board of directors
generally vest monthly over one year. Shares issued upon exercise of options are generally issued from new shares of the Company.

The Company accounts for
stock based compensation according to the provisions of Statement of Financial Accounting Standards 123 (R),Share Based Payment (SFAS No. 123(R)). The fair value of each stock option is estimated on the date of grant using the
Black-Scholes Option Pricing Model. The risk-free interest rate is based on a treasury instrument, the term of which is consistent with the expected life of the stock options. Expected volatility is based exclusively on historical volatility data of
the Companys stock. The Company was unable to use historical information to estimate the expected term due to a lack of historical exercise activity and therefore used the simplified method as permitted by the Securities and
Exchange CommissionStaff Accounting Bulletin No. 107 . The Company estimated the stock option forfeitures based on historical experience and adjusted this assumption to reflect expected forfeitures over the remaining vesting
period. This estimate is evaluated quarterly and the forfeiture rate is adjusted as necessary. Ultimately, the actual expense recognized over the vesting period will only be for those shares that vest. The Company has elected to recognize
compensation cost for awards with pro rata vesting using the straight-line method.



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BIOPURE CORPORATION

Notes to Condensed Consolidated Financial Statements

April 30, 2009

(Unaudited)

During the first six months of fiscal 2009 no
options were granted, there were 228,777 options granted in the first six months of fiscal 2008. As a consequence of staff reductions in November 2008, options to purchase 884,249 shares of common stock were forfeited or cancelled. Stock based
compensation for the three and six months ending April 30, 2009 was $36,000 and $106,000 respectively, which is included in general and administrative expenses in the accompanying statement of operations.

As of April 30, 2009, there was approximately $37,000 of unrecognized compensation expense, net of forfeitures, related to non-vested market-based share awards to
be recognized over a weighted-average period of .50 years.

No options were exercised during the first six months of fiscal 2009 or fiscal 2008. The total
fair values of shares vested during the first six months of fiscal 2009 and 2008 were approximately $250,000 and $222,000, respectively.

A summary of
option activity under the plans as of April 30, 2009 and changes during the year then ended is presented below (in thousands, except weighted average data):



|                                              |  |                       |   |  |                               |       |                                        |      |                         |   |  
|--------------------------------------------- |  | --------------------- | - |  | ----------------------------- | ----- | -------------------------------------- | ---- | ----------------------- | - | -
|                                              |  | Number ofStockOptions |   |  | Weighted-AverageExercisePrice |       | Weighted-AverageRemainingLife in Years |      | AggregateIntrinsicValue
|Outstanding at October 31, 2008               |  | 2,819,584             |   |  | $                             | 6.23  |                                        |      |                         |   |  
|Granted                                       |  |                      |   |  |                               |      |                                        |      |                         |   |  
|Exercised                                     |  |                      |   |  |                               |      |                                        |      |                         |   |  
|Forfeited/Cancelled/Expired                   |  | (1,770,336            | ) |  |                               | 0.80  |                                        |      |                         |   |  
|                                              |  |                       |   |  |                               |       |                                        |      |                         |   |  
|Outstanding at April 30, 2009                 |  | 1,049,248             |   |  |                               | 13.80 |                                        | 4.86 |                         | $ | 
|                                              |  |                       |   |  |                               |       |                                        |      |                         |   |  
|Exercisable at April 30, 2009                 |  | 955,763               |   |  |                               | 15.03 |                                        | 4.79 |                         | $ | 
|                                              |  |                       |   |  |                               |       |                                        |      |                         |   |  
|Vested and expected to vest at April 30, 2009 |  | 1,049,248             |   |  |                               | 13.80 |                                        | 4.86 |                         | $ | 
|                                              |  |                       |   |  |                               |       |                                        |      |                         |   |  



|4. | Inventories
|-- | -----------

Inventories are valued at the lower of cost (determined using
the first-in, first-out method) or market. Inventories were as follows at the following dates:



|                         |  |                |     |                  |   |      
|------------------------ |  | -------------- | --- | ---------------- | - | -----
|In thousands             |  | April 30, 2009 |     | October 31, 2008
|Raw materials            |  | $              | 396 |                  | $ | 375  
|Work-in-process          |  |                | 13  |                  |   | 12   
|Finished goods-Oxyglobin |  |                | 2   |                  |   | 720  
|Finished goods-Hemopure  |  |                | 575 |                  |   | 888  
|                         |  |                |     |                  |   |      
|                         |  | $              | 983 |                  | $ | 1,995
|                         |  |                |     |                  |   |      

The inventory of Hemopure finished goods represents units the Company expects to sell in South Africa or use in
preclinical or clinical studies where payment is received for the trial material. Each reporting period the Company reviews the inventory of Hemopure finished goods and, if necessary, writes off any units beyond those forecasted for these purposes,
resulting in a charge to operations through cost of revenue or research and development. There were no write-offs of inventory during the six month period ending April 30, 2009 or 2008.



8



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##### Table of Contents

|5. | Accrued Expenses
|-- | ----------------

Accrued expenses were as follows at the following dates:



|                                              |  |                |       |                  |   |      
|--------------------------------------------- |  | -------------- | ----- | ---------------- | - | -----
|In thousands                                  |  | April 30, 2009 |       | October 31, 2008
|Accrued payroll and related employee expenses |  | $              | 25    |                  | $ | 175  
|Financing fees                                |  |                | 537   |                  |   | 537  
|Accrued legal and audit fees                  |  |                | 141   |                  |   | 312  
|Accrued severance                             |  |                |      |                  |   | 11   
|Accrued vacation                              |  |                | 35    |                  |   | 189  
|Accrued utilities                             |  |                | 30    |                  |   | 49   
|Other                                         |  |                | 303   |                  |   | 513  
|                                              |  |                |       |                  |   |      
|                                              |  | $              | 1,071 |                  | $ | 1,786
|                                              |  |                |       |                  |   |      



9



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##### Table of Contents

BIOPURE CORPORATION

Notes to Condensed Consolidated Financial Statements

April 30, 2009

(Unaudited)



|6. | Commitments and Contingencies
|-- | -----------------------------

In 2003, the Company
entered into a Cooperative Research and Development Agreement (CRADA) with the NMRC. As part of CRADA, the NMRC paid approximately $1.2 million for inventory purchases to be delivered in the future, recorded in the accompanying consolidated
financial statements as deferred revenue. If the NMRC were to decide not to continue to pursue a trauma indication, as described in the CRADA, the Company could be required to return the $1.2 million.(1)



|7. | Litigation
|-- | ----------

The seven members of the Companys Board of Directors
during the period March through December 2003 and certain officers during that period were named as defendants in two stockholder derivative actions filed on January 26, 2004 and January 29, 2004 in the U.S. District Court for the District
of Massachusetts. A consolidated, amended complaint was filed in regard to Biopure Corporation Derivative Litigation. Biopure is named as a defendant, even though in a derivative action, any award is for the benefit of the Company, not individual
stockholders. The consolidated, amended complaint alleges that the individual directors and officers breached fiduciary duties in connection with disclosures concerning regulatory and clinical events. The complaint does not specify an amount of
alleged damages. The Company appointed two disinterested directors as a special litigation committee to determine whether or not the Company should pursue this action. The special litigation committee conducted its investigation and determined the
Company should not pursue the action. The special litigation committee filed a motion to dismiss the action A proposed settlement of the case was filed with the court. The court has scheduled a hearing (the Settlement Hearing) on
July 24, 2009 to: (a) determine whether the court should approve the settlement as fair, reasonable, adequate and in the best interests of shareholders; (b) determine whether an order and final judgment should be entered pursuant to
the stipulated settlement; (c) consider the request by plaintiffs counsel for an award of attorneys fees and expenses; and (d) rule on such other matters as the court may deem appropriate. The proposed settlement will have no
financial effect on the Company.

On March 17, 2009, the Company was served with a complaint captioned Americas Growth Capital, L.L.C. v.
Biopure Corporation. The case was filed in the Superior Court, Commonwealth of Massachusetts (Civil action no. 09  0956). The complaint seeks damages in an unspecified amount, alleged to be owed by the Company under an agreement dated
April 22, 2008, in which the Company engaged the plaintiff to act as its exclusive placement agent in connection with the private placement of approximately $1015 million of Company convertible debentures or any other securities. The
complaint asks for relief in the form of a declaratory judgment and compensation on the bases of breach of contract, breach of the covenant of good faith and fair dealing, unjust enrichment and violation of Massachusetts law (M.G.L. c. 93A). The
Company believes that it has meritorious defenses, but it is too early in the litigation for it to have assessed the matter fully. It intends to defend itself against the litigation.



|8. | Recently Issued Accounting Standards
|-- | ------------------------------------

In December 2007, the FASB issued
SFAS No. 141 (revised 2007),Business Combinations (SFAS 141(R)). In SFAS 141(R), the FASB retained the fundamental requirements of Statement No. 141 to account for all business combinations using the
acquisition method (formerly the purchase method) and for an acquiring entity to be identified in all business combinations. However, the new standard requires the acquiring entity in a business combination to recognize all (and only) the assets
acquired and liabilities assumed in the transaction; establishes the acquisition-date fair value as the measurement objective for all assets acquired and liabilities assumed; and requires the acquirer to disclose to investors and other users all of
the information they need to evaluate and understand the nature and financial effect of the business combination. SFAS 141(R) is effective for annual periods beginning on or after December 15, 2008 (beginning with the Companys 2010
fiscal year) and will change the accounting for business combinations on a prospective basis.

In September 2006, the FASB issued SFAS No. 157,Fair Value Measurements (SFAS 157). SFAS 157 defines fair value, establishes a framework for measuring fair value under other accounting pronouncements that permit or require fair value measurements, changes the methods used to
measure fair value and expands disclosures about fair value measurements. In particular, disclosures are required to provide information on the extent to which fair value is used to measure assets and liabilities; the inputs used to develop
measurements; and the effects of certain of the measurements on earnings (or changes in net assets). SFAS 157 eliminates the use of a blockage factor for fair value measurements of financial instruments trading in an active market. SFAS 157 is
effective for fiscal years beginning after November 15, 2007 and interim periods within those fiscal years. The application of SFAS 157 has not had a material impact on the Companys results of operations or financial position since its
adoption as of November 1, 2008.

In February 2008, the FASB issued FASB Staff Position (FSP) FAS 157-2,Effective Date of FASB
Statement No. 157, which defers the effective date of SFAS No. 157 to fiscal years beginning after November 15, 2008 for nonfinancial assets and nonfinancial liabilities except those recognized or disclosed at fair value on an
annual or more frequently recurring basis. The Company is required to apply the fair value measurement and disclose provisions of SFAS No. 157 to nonfinancial assets and liabilities effective November 1, 2009. The application of such is
not expected to be material to the Companys results of operations or financial position results of operations or financial position.

EITF
No. 07-5, Determining Whether an Instrument is Indexed to an Entitys Own Stock(EITF 07-5) is effective for the Company for annual and interim reporting periods beginning November 1, 2009.EITF
07-5 replaces the guidance in EITF Issue 01-6, The Meaning of Indexed to a Companys Own Stock.Both Issues 01-6 and 07-5 require an entity to evaluate an instruments contingency provisions and the factors that affect
its ultimate settlement amount (i.e., the payoff to the holder) when determining whether the instrument is indexed to the entitys own stock. The Company is currently evaluating the impact this standard may have on the Companys
consolidated financial statements.



(1)The content of this document does not
necessarily reflect the position or the policy of the U.S. Government or the Department of Defense, and no official endorsement should be inferred of the Navy. Biopure collaborative clinical development program for Hemopure in trauma is contingent
upon funding.



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##### Table of Contents

|9. | Sale of Property
|-- | ----------------

In January 2009 the Company sold its plant in
Pennsylvania and entered into a lease as lessee of the plant. The consideration included $1.2 million in cash and approximately $230,000 in rent abatements. The initial term of the lease is three years, and it can be renewed at the Companys
option for five additional terms of five years each. The Company recorded a deferred gain and deferred rent of approximately $41,000 and $160,000, respectively, as a result of this transaction; each deferral will be recognized over the initial lease
term of three years.



11



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##### Table of Contents

BIOPURE CORPORATION

Managements Discussion and Analysis of

Financial Condition and Results of
Operations

April 30, 2009



|Item 2. | Managements Discussion and Analysis of Financial Condition and Results of Operations
|------- | -------------------------------------------------------------------------------------

Cautionary Statement Regarding Forward-Looking Information

The following discussion of the Companys financial
condition and results of operations includes forward-looking statements. These forward-looking statements include, without limitation, statements about the viability of the Company, the prospects for further clinical development of its products,
other expected activities, finding an appropriate transaction to continue the Company or liquidating the company. Forward-looking statements include those that imply that the Company will be able to manage its expenses effectively and raise the
funds needed to continue its business, that the Company will be able to stabilize and enhance its financial position, that the Company will be able to commercially develop Hemopure, that in pursuing clinical development the Company will be able to
address safety and efficacy questions of regulatory agencies, that the U.S. Naval Medical Research Center (NMRC) may conduct a clinical trial in trauma patients, and that anticipated milestones will be met in the expected timetable or at all,
that any preclinical or clinical trials will be successful, that Hemopure, if it receives regulatory approval, will attain market acceptance and be manufactured and sold in amounts to attain profitability and that the Company will be able to
successfully increase its manufacturing capacity for Hemopure if it receives regulatory approval. Forward-looking statements are usually accompanied by words such as believe, anticipate, plan, seek,
expect, intend and similar expressions. The forward-looking information is based on various factors and was derived using numerous assumptions and judgments.

Actual results may differ materially from those set forth in the forward-looking statements due to risks and uncertainties that exist in the Companys operations and business environment. These risks include the
factors identified under Risk Factors in this report. All forward-looking statements included or incorporated by reference in this report are based on information available to the Company on the date such statements were made. In light
of the substantial risks and uncertainties inherent in all future projections, the inclusion of forward-looking statements in this report should not be regarded as representations by us that the Companys objectives or plans will be achieved.
The Company undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise. You are advised, however, to consult any additional disclosures the Company makes in its
reports to the SEC on Forms 10-Q, 8-K, 10-K and 10-K/A.

The content of this document does not necessarily reflect the position or the policy of the
U.S. Government or the Department of Defense, and no official endorsement should be inferred.

Overview

Since its founding in 1984, Biopure has been primarily a research and development company focused on developing Hemopure, the Companys oxygen therapeutic for human
use, and obtaining regulatory approval in the United States and other markets. The Companys research and development expenses have been devoted to basic research, product development, process development, preclinical studies, clinical trials
and regulatory activity. In addition, the Companys development expenses in the past included the design, construction, validation and maintenance of a large-scale pilot manufacturing plant in Cambridge, Massachusetts.

Prior to 1998, the Company manufactured products solely for use in preclinical and clinical trials, and production costs were charged wholly to research and development.
As an offshoot of the research and development for Hemopure, Oxyglobin, a similar product, gained marketing approval for veterinary use in the United States in 1998 and in the European Union in 1999. Following the U.S. approval, Oxyglobin was
produced for sale in the same pilot manufacturing plant that was built and maintained primarily for the development of Hemopure. Because of this marketing approval, costs of production of Oxyglobin for sale and an allocation of manufacturing
overhead based on capacity used for Oxyglobin are charged to inventory and to cost of revenues. Since marketing approval of Hemopure for human use was granted in South Africa in 2002, costs of production of Hemopure for sale and an allocation of
manufacturing overhead based on capacity used for Hemopure have been charged to inventory and to cost of revenues.

A substantial majority of our costs
have comprised research and development and cost of revenues. The revenues from products we have marketed defrayed some of the manufacturing costs we have incurred to manufacture Hemopure. The Company suspended manufacturing operations and virtually
all other activity beginning in the third quarter of fiscal 2008 to conserve cash and seek a way forward through financing or a corporate transaction. The Company has been unable to obtain financing sufficient to sustain it through meaningful
further development of its product, Hemopure. In February 2009, the company engaged an investment banker to assist in considering strategic alternatives such as capital raising, strategic alliances, or a sale of the company or of some, all or
substantially all of the companys assets.

Research and development activities in 2009 and 2008 are described below. The Company does not currently
have any trials enrolling patients.



12



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##### Table of Contents

Cost Cutting Measures

During fiscal 2008 and 2009, the Company took measures to reduce its ongoing cash burn. In November 2008, it effected reductions in force and shut down its manufacturing facility in Cambridge and its processing facility in Pennsylvania. By
November 2008 all but four of its employees had been laid off. The Company has engaged several former employees on a part-time basis and has continued limited operations since then.

Liquidity and Capital Resources

At April 30, 2009, the Company had $245,000 in cash and cash equivalents.
During the first fiscal quarter of 2009, the Company drastically reduced operations, a process that began in the second quarter of fiscal 2008. In January 2009, the Company sold substantially all of its existing inventory of Oxyglobin to the
Companys U.S. distributor, an affiliate of the Companys European distributor, for sale in Europe and the United States. The proceeds of that sale were $796,000. In March 2009, the Company also sold its manufacturing facility in
Pennsylvania and entered into a lease of the facility from the purchaser. The consideration was for $1.2 million in cash and approximately $230,000 in rent abatements. The Company has leased the facility, and, as additional consideration from the
purchaser, the initial term of the lease is at a rent the Company believes to be below market. The initial term of the lease is three years; during this term the rental is approximately $6,000 per month. The Company has the option to renew for five
additional terms of five years each at increasing rates.

The Company expects that its current cash and accounts receivable will fund operations through
July 2009. It expects to cease operations and sell the Company or its assets. The Company is now engaged in discussions concerning its course of action. There can be no assurance that ongoing discussions will lead to a transaction. The
Companys primary commitments for future expenditures are its commitments under real property leases.

Net cash used in operating activities decreased
$8,944,000 in the first six months of fiscal 2009 compared to the corresponding period in fiscal 2008 because of the work force reductions described above and other measures to control costs. Cash used in operating activities was $2,015,000 for the
first six months of fiscal 2009.

Results of Operations

As the Company generates net losses, the key drivers of the losses have been cost of revenues, research and development and general and administrative expenses. Inflation and changing prices have not had a significant impact on the revenues
or loss from operations in the periods presented below. The key drivers of losses in the three and six month period ending April 30, 2009 have changed because of the suspension of Company activity in fourth quarter of 2008 and the first quarter
of fiscal 2009. For the three and six-month periods ended April 30, 2009 and 2008, these items were as follows (dollars in thousands):



|                                  |  |                    |       |                       |                  |   |        |                |                       |  |                |        |  |                       |       |  |        |   |                       |   |        |  |     |  
|--------------------------------- |  | ------------------ | ----- | --------------------- | ---------------- | - | ------ | -------------- | --------------------- |  | -------------- | ------ |  | --------------------- | ----- |  | ------ | - | --------------------- | - | ------ |  | --- | -
|                                  |  | Three Months Ended |       |                       | Six Months Ended |  
|                                  |  | April 30, 2009     |       |                       | April 30, 2008   |   |        | April 30, 2009 |                       |  | April 30, 2008 |       
|                                  |  | Amount             |       | Percent ofTotal Costs |                  |   | Amount |                | Percent ofTotal Costs |  |                | Amount |  | Percent ofTotal Costs |       |  | Amount |   | Percent ofTotal Costs |  
|Oxyglobin Product Sales           |  | $                  |      |                       |                  |   |        | $              | 777                   |  |                |        |  | $                     | 797   |  |        |   |                       | $ | 1,196  |  |     |  
|Hemopure Product Sales            |  |                    | 13    |                       |                  |   |        |                | 89                    |  |                |        |  |                       | 81    |  |        |   |                       |   | 147    |  |     |  
|Research and Development Revenues |  |                    | 334   |                       |                  |   |        |                | 36                    |  |                |        |  |                       | 627   |  |        |   |                       |   | 132    |  |     |  
|                                  |  |                    |       |                       |                  |   |        |                |                       |  |                |        |  |                       |       |  |        |   |                       |   |        |  |     |  
|Total Revenues                    |  |                    | 347   |                       |                  |   |        |                | 902                   |  |                |        |  |                       | 1,505 |  |        |   |                       |   | 1,475  |  |     |  
|Cost of Revenues                  |  |                    |       |                       |                  |   |        |                |                       |  |                |        |  |                       |       |  |        |   |                       |   |        |  |     |  
|Oxyglobin                         |  |                    |      |                       | 0                | % |        |                | 645                   |  | 11             | %      |  |                       | 706   |  | 13     | % |                       |   | 1,214  |  | 10  | %
|Hemopure                          |  |                    | 9     |                       | 0                | % |        |                | 1,168                 |  | 20             | %      |  |                       | 303   |  | 5      | % |                       |   | 3,387  |  | 27  | %
|                                  |  |                    |       |                       |                  |   |        |                |                       |  |                |        |  |                       |       |  |        |   |                       |   |        |  |     |  
|Total Cost of Revenues            |  |                    | 9     |                       | 0                | % |        |                | 1,813                 |  | 31             | %      |  |                       | 1,009 |  | 18     | % |                       |   | 4,601  |  | 37  | %
|Research and Development          |  |                    | 208   |                       | 10               | % |        |                | 1,756                 |  | 29             | %      |  |                       | 1,328 |  | 23     | % |                       |   | 3,243  |  | 26  | %
|Sales and Marketing Oxyglobin     |  |                    | 5     |                       | 0                | % |        |                | 48                    |  | 0              | %      |  |                       | 17    |  | 0      | % |                       |   | 73     |  | 0   | %
|Hemopure                          |  |                    | 49    |                       | 2                | % |        |                | 400                   |  | 7              | %      |  |                       | 133   |  | 2      | % |                       |   | 655    |  | 5   | %
|                                  |  |                    |       |                       |                  |   |        |                |                       |  |                |        |  |                       |       |  |        |   |                       |   |        |  |     |  
|Total Sales and Marketing         |  |                    | 54    |                       | 2                | % |        |                | 448                   |  | 7              | %      |  |                       | 150   |  | 2      | % |                       |   | 728    |  | 5   | %
|General and Administrative        |  |                    | 1,906 |                       | 88               | % |        |                | 1,947                 |  | 33             | %      |  |                       | 3,234 |  | 57     | % |                       |   | 3,948  |  | 32  | %
|                                  |  |                    |       |                       |                  |   |        |                |                       |  |                |        |  |                       |       |  |        |   |                       |   |        |  |     |  
|Total Costs                       |  | $                  | 2,177 |                       | 100              | % |        | $              | 5,964                 |  | 100            | %      |  | $                     | 5,721 |  | 100    | % |                       | $ | 12,520 |  | 100 | %



13



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##### Table of Contents

Six months April 30, 2009 compared to six months ended April 30, 2008

Total revenues for the first six months of fiscal 2009 were $ 1.5 million and in 2008 were $1.5 million. The 2009 revenue is attributable to the Company selling
substantially all of its inventory of Oxyglobin to distributors in the first quarter of 2009. The Company does not expect additional revenue from sales of Oxyglobin for the balance of fiscal 2009 and until such later time as it resumes
manufacturing.

Revenues from sales of Hemopure were $81,000 for the first six months of fiscal 2009 compared to $147,000 for the same period in 2008. In
November 2008, the Companys sales personnel in South Africa were laid off. Sales are continuing, but the Company is not actively marketing to customers and does not expect sales to increase. In addition, the South Africa regulatory authority
notified the Company in October 2008 that it had decided to revoke its marketing authorization for Hemopure. The Company is appealing that decision. During the pendency of the appeal, the Company is permitted to sell the product.

Cost of revenues includes costs of both Oxyglobin and Hemopure. Cost of revenues was $1.0 million for the first six months of fiscal 2009, compared to $4.6 million for
the same period in 2008. Hemopure cost of revenues was $3.0 million lower for the first six months of fiscal 2009 than for the first six months of fiscal 2008 because of the suspension of manufacturing and reduction of manufacturing personnel
described above. This suspension in operations caused a reclassification of the underlying costs, yielding a reduction in cost of goods sold with a correlating increase in research and development expense.

Research and development costs decreased from $3.2 million for the first six months of fiscal 2008 to $1.3 million for the first six months of fiscal 2009 because of a
severe curtailment of operations in the first quarter of 2009. Sales and marketing expenses decreased from $728,000 for the first six months of fiscal 2008 to $150,000 for the first six months of fiscal 2009, also because of reduced activity. The
sales personnel in South Africa were terminated in November 2008.

General and administrative expenses were $3.2 million for the first six months of fiscal
2009 compared to $3.9 million for the same period in 2008 because of staff reductions and related reductions in expenses.

The Company does not expect its
recent results of operations to be indicative of continuing operations, as it has not raised capital and anticipates a fundamental change in the ownership of the Companys assets or a liquidation in the near future.

Three months April 30, 2009 compared to Three months ended April 30, 2008

Total revenues for three months ended April 30, 2009 were $347,000, and total revenues for the same period in 2008 were $902,000.

Revenues from sales of Hemopure were $13,000 for the three months ended April 30, 2009 compared to $89,000 for the same period in 2008. In November 2008, the Companys sales personnel in South Africa were
laid off. Sales are continuing, but at low levels, as the Company is not actively marketing to customers. In addition, the South Africa regulatory authority notified the Company in October 2008 that it had decided to revoke its marketing
authorization for Hemopure. The Company is appealing that decision. During the pendency of the appeal, the Company is permitted to continue to sell product. There was no revenue from sales of Oxyglobin in the second quarter of 2009 because
substantially all of the Oxyglobin inventory was sold in the first quarter, and there was no manufacturing or sales of Oxyglobin in the second quarter.

Cost of revenues includes costs of both Oxyglobin and Hemopure. Cost of revenues was $9,000 for the three months ended April 30, 2009, compared to $1.0 million for the same period in 2008. There were no cost of revenues for Oxyglobin
in the quarter ended April 30, 2009, because substantially all of the Companys Oxyglobin inventory was sold to the Companys U.S. distributor in the first quarter of 2009. Hemopure cost of revenues was $1.2 million lower for the
three months ended April 30, 2009 than for the same period in 2008 because of the suspension of manufacturing and reduction of manufacturing personnel described above and lower sales in 2009.

Research and development costs decreased from $1.8 million for the three months ended April 30, 2008 to $208,000 for the three months ended April 30, 2009
because of lack of personnel and activity. Sales and marketing expenses decreased from $448,000 for the three months ended April 30, 2008 to $54,000 for the three months ended April 30, 2009 also due to reduced activity and the termination
in November 2008 of the sales staff in South Africa.

General and administrative expenses were $41,000 lower in the three months ended April 30, 2009
than the comparable period and in 2008 because of layoffs and reduction of other expenses.



|Item 3. | Quantitative and Qualitative Disclosure About Market Risk
|------- | ---------------------------------------------------------

Not
applicable.



|Item 4T. | Controls and Procedures
|-------- | -----------------------

(a) Evaluation of Disclosure Controls and
Procedures.

The Companys management, under the supervision of and with the participation of the Chief Executive Officer, performed an evaluation of
the effectiveness of its disclosure controls and procedures (as defined in Rules 13a-15(e) under the Securities Exchange Act of 1934 (the Exchange Act) as of the end of the period covered by this report April 30, 2009. Based on this
evaluation, the Chief Executive Officer concluded that the Companys disclosure controls and procedures were effective as of the end of the period covered by this report to ensure that information required to be disclosed by the Company in its
Exchange Act reports is recorded, processed, summarized and reported within the time periods specified in SEC rules and forms.



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##### Table of Contents

(b) Changes in Internal Control Over Financial Reporting

There have been no changes in the Companys internal control over financial reporting (as defined under Rules 13a-(f) or 15d-15(f) of the Exchange Act) during the quarter ended April 30, 2009, that have
materially affected, or are reasonably likely to materially affect, the Companys internal control over financial reporting. As previously reported in the Companys annual report on Form 10-K/A, as filed with the SEC on March 3, 2009,
management identified material weaknesses in the internal control over financial reporting in the last quarter of fiscal 2008.



15



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##### Table of Contents

BIOPURE CORPORATION

Part IIOther Information

April 30, 2009



|Item 1. | Legal Proceedings
|------- | -----------------

The information in Note 7 to the Condensed
Consolidated Financial Statements is incorporated herein by reference.



|Item 1A. | Risk Factors
|-------- | ------------

The Company anticipates ceasing operations in
the near future.

As noted in this report, we have limited remaining cash. We are exploring the potential sale of some, substantially all, or
all of our assets, and we are considering liquidating the company. A liquidation may occur after a sale or in lieu of a sale. A sale or a liquidation could result in no proceeds to holders of our common stock or result in proceeds that are
substantially less than the market value of such common stock prior to the announcement of the sale or liquidation. There is substantial risk that our securities will have little or no value following a sale or liquidation.



16



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##### Table of Contents

|Item 2. | Unregistered Sales of Equity Securities and Use of Proceeds
|------- | -----------------------------------------------------------

None.



|Item 3. | Defaults Upon Senior Securities
|------- | -------------------------------

None.



|Item 4. | Submission of Matters to a Vote of Security Holders
|------- | ---------------------------------------------------

None.



|Item 5. | Other Information
|------- | -----------------

None.



|Item 6. | Exhibits
|------- | --------

The Exhibits listed in the Exhibit Index are filed with,
or incorporated by reference in, this report.



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##### Table of Contents

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.



|                    |  |                     |  |                                      
|------------------- |  | ------------------- |  | -------------------------------------
|                    |  | BIOPURE CORPORATION
|                    |  |                    
|Date: June 22, 2009 |  | By:                 |  | /s/ Zafiris G. Zafirelis             
|                    |  |                     |  | Zafiris G. Zafirelis                 
|                    |  |                     |  | President and Chief Executive Officer



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EXHIBIT INDEX



|     |  |                                                                                                                                                          
|---- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------
|31.1 |  | Certification of the Chief Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                  
|     | 
|31.2 |  | Certification of the Principal Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                              
|     | 
|32.1 |  | Certification of the Chief Executive Officer Pursuant to 18 U.S.C Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.    
|     | 
|32.2 |  | Certification of the Principal Financial Officer Pursuant to 18 U.S.C Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.



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