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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, DC 20549





FORM 10-Q/A







|x | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ---------------------------------------------------------------------------------------

For the quarterly period ended April 30, 2008



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from            
to

Commission File Number 001-15167





BIOPURE CORPORATION

(Exact name of registrant as specified in its charter)







|                         |  |                                     
|------------------------ |  | ------------------------------------
|Delaware                 |  | 04-2836871                          
|(State of Incorporation) |  | (IRS Employer Identification Number)



|                                           |  |           
|------------------------------------------ |  | ----------
|11 Hurley Street, Cambridge, Massachusetts |  | 02141     
|(Address of principal executive offices)   |  | (Zip Code)

(617) 234-6500

(Registrants telephone number)





Indicate by check mark whether the registrant
(1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and
(2) has been subject to such filing requirements for the past 90 days.    x  Yes     ̈  No

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See
definitions of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the Exchange Act.

Large accelerated filer   ̈    Accelerated filer   ̈    Non-accelerated
filer   ̈    Smaller reporting company  x

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).     ̈  Yes    x  No

The number of shares outstanding of each of the issuers classes of common stock as of June 12, 2008 was:



|                                      |  |           
|------------------------------------- |  | ----------
|Class A Common Stock, $.01 par value  |  | 34,971,087
|Class B Common Stock, $1.00 par value |  | 117.7     









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EXPLANATORY NOTE

Biopure Corporation filed its Quarterly Report on Form 10-Q for the quarterly period ended April 30, 2008 with the Securities and Exchange Commission (SEC) on June 16, 2008 (the Original 10-Q).
After we filed the Original 10-Q, we determined that we had made a clerical error in the financial statements included in the Original 10-Q. In our Condensed Consolidated Statements of Operations, we erroneously reported Basic and diluted net
loss per common share for the Three Months Ended April 30, 2007 and the Six Months Ended April 30, 2007 as $(0.08) and $(0.18), respectively. The correct Basic and diluted net loss per common share for the Three Months
Ended April 30, 2007 and the Six Months Ended April 30, 2007 was $(0.40) and $(0.92), respectively. We also erroneously reported Weighted-average shares used in computing basic and diluted net loss per common share for the Six
Months Ended April 30, 2007 as 15,562 shares. The correct Weighted-average shares used in computing basic and diluted net loss per common share for the Six Months Ended April 30, 2007 was 14,237 shares. This Amendment
No. 1 to our Quarterly Report on Form 10-Q for the quarterly period ended April 30, 2008 amends the Original 10-Q in its entirety to reflect the changes described above.



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BIOPURE CORPORATION

INDEX TO FORM 10-Q



|                                                                                                                     |  |     
|-------------------------------------------------------------------------------------------------------------------- |  | ----
|                                                                                                                     |  | Page
|Part IFinancial Information:                                                                                        |  |     
|Item 1Financial Statements (Unaudited)                                                                              |  |     
|Condensed Consolidated Balance Sheets at April 30, 2008 and October 31, 2007                                         |  | 3   
|Condensed Consolidated Statements of Operations for the three and six months ended April 30, 2008 and April 30,
2007 |  | 4   
|Condensed Consolidated Statements of Cash Flows for the three and six months ended April 30, 2008 and April 30,
2007 |  | 5   
|Notes to Condensed Consolidated Financial Statements                                                                 |  | 6   
|Item 2Managements Discussion and Analysis of Financial Condition and Results of
Operations                         |  | 11  
|Item 3Quantitative and Qualitative Disclosure of Market Risk                                                        |  | 16  
|Item 4Controls and Procedures                                                                                       |  | 16  
|Part IIOther Information:                                                                                           |  |     
|Item 1Legal Proceedings                                                                                             |  | 17  
|Item 1ARisk Factors                                                                                                 |  | 17  
|Item 2Unregistered Sales of Equity Securities and Use of Proceeds                                                   |  | 24  
|Item 3Defaults Upon Senior Securities                                                                               |  | 24  
|Item 4Submission of Matters to a Vote of Security Holders                                                           |  | 24  
|Item 5Other Information                                                                                             |  | 25  
|Item 6Exhibits                                                                                                      |  | 25  
|Signatures                                                                                                           |  | 26  
|Exhibit Index                                                                                                        |  | 27  

Biopure®, Hemopure®, and Oxyglobin® are registered trademarks of Biopure Corporation.



2



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Part I

Item 1

BIOPURE CORPORATION

Condensed Consolidated Balance Sheets

(In
thousands, except share and per share data)

(Unaudited)



|                                                                                                                                            |  |               |          |   |                 |   |          |  
|------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------- | -------- | - | --------------- | - | -------- | -
|                                                                                                                                            |  | April 30,2008 |          |   | October 31,2007 |  
|Assets:                                                                                                                                     |  |               |          |   |                 |   |          |  
|Current assets:                                                                                                                             |  |               |          |   |                 |   |          |  
|Cash and cash equivalents                                                                                                                   |  | $             | 5,685    |   |                 | $ | 1,910    |  
|Accounts receivable, net                                                                                                                    |  |               | 205      |   |                 |   | 59       |  
|Inventories                                                                                                                                 |  |               | 3,156    |   |                 |   | 2,119    |  
|Other current assets                                                                                                                        |  |               | 1,080    |   |                 |   | 1,165    |  
|                                                                                                                                            |  |               |          |   |                 |   |          |  
|Total current assets                                                                                                                        |  |               | 10,126   |   |                 |   | 5,253    |  
|Property, plant and equipment, net                                                                                                          |  |               | 7,645    |   |                 |   | 8,398    |  
|Other assets                                                                                                                                |  |               | 552      |   |                 |   | 599      |  
|                                                                                                                                            |  |               |          |   |                 |   |          |  
|Total assets                                                                                                                                |  | $             | 18,323   |   |                 | $ | 14,250   |  
|                                                                                                                                            |  |               |          |   |                 |   |          |  
|Liabilities and stockholders equity:                                                                                                       |  |               |          |   |                 |   |          |  
|Current liabilities:                                                                                                                        |  |               |          |   |                 |   |          |  
|Accounts payable                                                                                                                            |  | $             | 381      |   |                 | $ | 777      |  
|Accrued expenses                                                                                                                            |  |               | 2,470    |   |                 |   | 2,512    |  
|Current portion of deferred revenue                                                                                                         |  |               | 35       |   |                 |   | 35       |  
|Accrued restructuring charges                                                                                                               |  |               |         |   |                 |   | 44       |  
|Other current liabilities                                                                                                                   |  |               | 57       |   |                 |   |         |  
|                                                                                                                                            |  |               |          |   |                 |   |          |  
|Total current liabilities                                                                                                                   |  |               | 2,943    |   |                 |   | 3,368    |  
|Deferred revenue, net of current portion                                                                                                    |  |               | 1,177    |   |                 |   | 1,177    |  
|Other long-term liabilities                                                                                                                 |  |               |         |   |                 |   | 41       |  
|                                                                                                                                            |  |               |          |   |                 |   |          |  
|Total long-term liabilities                                                                                                                 |  |               | 1,177    |   |                 |   | 1,218    |  
|Commitments and contingencies, Note 7                                                                                                       |  |               |          |   |                 |   |          |  
|Stockholders equity:                                                                                                                       |  |               |          |   |                 |   |          |  
|Preferred stock, $0.01 par value, 30,000,000 shares authorized, no shares outstanding                                                       |  |               |         |   |                 |   |         |  
|Common stock:                                                                                                                               |  |               |          |   |                 |   |          |  
|Class A, $0.01 par value, 200,000,000 shares authorized, 34,971,087 shares outstanding at April 30, 2008 and 15,593,587 at
October 31, 2007 |  |               | 350      |   |                 |   | 156      |  
|Class B, $1.00 par value, 179 shares authorized, 117.7 shares outstanding                                                                   |  |               |         |   |                 |   |         |  
|Capital in excess of par value                                                                                                              |  |               | 561,831  |   |                 |   | 546,800  |  
|Contributed capital                                                                                                                         |  |               | 24,574   |   |                 |   | 24,574   |  
|Unrealized loss on currency translation                                                                                                     |  |               | (139     | ) |                 |   | (121     | )
|Accumulated deficit                                                                                                                         |  |               | (572,413 | ) |                 |   | (561,745 | )
|                                                                                                                                            |  |               |          |   |                 |   |          |  
|Total stockholders equity                                                                                                                  |  |               | 14,203   |   |                 |   | 9,664    |  
|                                                                                                                                            |  |               |          |   |                 |   |          |  
|Total liabilities and stockholders equity                                                                                                  |  | $             | 18,323   |   |                 | $ | 14,250   |  
|                                                                                                                                            |  |               |          |   |                 |   |          |  

See accompanying notes



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BIOPURE CORPORATION

Condensed Consolidated Statements of Operations

(In thousands, except per share data)

(Unaudited)



|                                                                                      |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|------------------------------------------------------------------------------------- |  | ------------------ | ------ | - | ---------------- | - | ------ | -------------- |  | - | -------------- | - |  | - | ------- | -
|                                                                                      |  | Three Months Ended |        |   | Six Months Ended |  
|                                                                                      |  | April 30, 2008     |        |   | April 30, 2007   |   |        | April 30, 2008 |  |   | April 30, 2007 |  
|Revenues:                                                                             |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|Product revenue                                                                       |  | $                  | 866    |   |                  | $ | 506    |                |  | $ | 1,343          |   |  | $ | 966     |  
|Research and development revenue                                                      |  |                    | 36     |   |                  |   | 113    |                |  |   | 132            |   |  |   | 247     |  
|                                                                                      |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|Total revenues                                                                        |  |                    | 902    |   |                  |   | 619    |                |  |   | 1,475          |   |  |   | 1,213   |  
|Cost of product revenues                                                              |  |                    | 1,813  |   |                  |   | 2,775  |                |  |   | 4,601          |   |  |   | 5,937   |  
|                                                                                      |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|Gross loss                                                                            |  |                    | (911   | ) |                  |   | (2,156 | )              |  |   | (3,126         | ) |  |   | (4,724  | )
|                                                                                      |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|Operating expenses:                                                                   |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|Research and development                                                              |  |                    | 1,756  |   |                  |   | 1,864  |                |  |   | 3,243          |   |  |   | 3,779   |  
|Sales and marketing                                                                   |  |                    | 448    |   |                  |   | 366    |                |  |   | 728            |   |  |   | 758     |  
|General and administrative                                                            |  |                    | 1,947  |   |                  |   | 2,027  |                |  |   | 3,948          |   |  |   | 4,258   |  
|                                                                                      |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|Total operating expenses                                                              |  |                    | 4,151  |   |                  |   | 4,257  |                |  |   | 7,919          |   |  |   | 8,795   |  
|                                                                                      |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|Loss from operations                                                                  |  |                    | (5,062 | ) |                  |   | (6,413 | )              |  |   | (11,045        | ) |  |   | (13,519 | )
|Other income, net                                                                     |  |                    | 201    |   |                  |   | 193    |                |  |   | 377            |   |  |   | 371     |  
|                                                                                      |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|Net loss                                                                              |  | $                  | (4,861 | ) |                  | $ | (6,220 | )              |  | $ | (10,668        | ) |  | $ | (13,148 | )
|                                                                                      |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|Per share data:                                                                       |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|Basic and diluted net loss per common share                                           |  | $                  | (0.14  | ) |                  | $ | (0.40  | )              |  | $ | (0.31          | ) |  | $ | (0.92   | )
|                                                                                      |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  
|Weighted-average shares used in computing basic and diluted net loss per common share |  |                    | 34,971 |   |                  |   | 15,562 |                |  |   | 34,439         |   |  |   | 14,237  |  
|                                                                                      |  |                    |        |   |                  |   |        |                |  |   |                |   |  |   |         |  

See accompanying notes



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BIOPURE CORPORATION

Condensed Consolidated Statements of Cash Flows

(In thousands)

(Unaudited)



|                                                                            |  |                  |         |   |                |   |         |  
|--------------------------------------------------------------------------- |  | ---------------- | ------- | - | -------------- | - | ------- | -
|                                                                            |  | Six Months Ended |        
|                                                                            |  | April 30, 2008   |         |   | April 30, 2007 |  
|Operating activities:                                                       |  |                  |         |   |                |   |         |  
|Net loss                                                                    |  | $                | (10,668 | ) |                | $ | (13,148 | )
|Adjustments to reconcile net loss to net cash used in operating activities: |  |                  |         |   |                |   |         |  
|Depreciation and amortization                                               |  |                  | 869     |   |                |   | 1,666   |  
|Stock based compensation                                                    |  |                  | 353     |   |                |   | 548     |  
|Loss on disposal of fixed asset                                             |  |                  | 32      |   |                |   | 20      |  
|Note receivable reserve                                                     |  |                  |        |   |                |   | 235     |  
|Accretion of restructuring charge                                           |  |                  | 1       |   |                |   | 4       |  
|Inventory writedowns                                                        |  |                  |        |   |                |   | 236     |  
|Changes in assets and liabilities:                                          |  |                  |         |   |                |   |         |  
|Accounts receivable                                                         |  |                  | (146    | ) |                |   | 19      |  
|Inventories                                                                 |  |                  | (1,037  | ) |                |   | (22     | )
|Other current assets                                                        |  |                  | 85      |   |                |   | 4       |  
|Other long term assets                                                      |  |                  | 19      |   |                |   |        |  
|Accounts payable                                                            |  |                  | (396    | ) |                |   | 124     |  
|Accrued expenses                                                            |  |                  | (42     | ) |                |   | (1,047  | )
|Restructuring charges                                                       |  |                  | (45     | ) |                |   | (94     | )
|Other current liabilities                                                   |  |                  | 57      |   |                |   |        |  
|Deferred revenue                                                            |  |                  |        |   |                |   | 68      |  
|Other long term liabilities                                                 |  |                  | (41     | ) |                |   |        |  
|                                                                            |  |                  |         |   |                |   |         |  
|Net cash used in operating activities                                       |  |                  | (10,959 | ) |                |   | (11,387 | )
|                                                                            |  |                  |         |   |                |   |         |  
|Investing activities:                                                       |  |                  |         |   |                |   |         |  
|Purchases of property, plant and equipment                                  |  |                  | (120    | ) |                |   | (114    | )
|                                                                            |  |                  |         |   |                |   |         |  
|Net cash used in investing activities                                       |  |                  | (120    | ) |                |   | (114    | )
|                                                                            |  |                  |         |   |                |   |         |  
|Financing activities:                                                       |  |                  |         |   |                |   |         |  
|Net proceeds from sale of common stock and warrants                         |  |                  | 14,872  |   |                |   | 16,388  |  
|                                                                            |  |                  |         |   |                |   |         |  
|Net cash provided by financing activities                                   |  |                  | 14,872  |   |                |   | 16,388  |  
|                                                                            |  |                  |         |   |                |   |         |  
|Net increase in cash and cash equivalents                                   |  |                  | 3,793   |   |                |   | 4,887   |  
|Effect of exchange rate changes on cash and cash equivalents                |  |                  | (18     | ) |                |   |        |  
|Cash and cash equivalents at beginning of period                            |  |                  | 1,910   |   |                |   | 6,576   |  
|                                                                            |  |                  |         |   |                |   |         |  
|Cash and cash equivalents at end of period                                  |  | $                | 5,685   |   |                | $ | 11,463  |  
|                                                                            |  |                  |         |   |                |   |         |  
|Supplemental disclosure of non-cash investing and financing transactions:   |  |                  |         |   |                |   |         |  
|Fair value of warrants issued in conjunction with sales of common stock     |  | $                | 9,270   |   |                | $ | 7,264   |  
|                                                                            |  |                  |         |   |                |   |         |  

See accompanying notes



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BIOPURE CORPORATION

Notes to Condensed Consolidated Financial Statements

April 30, 2008

(Unaudited)



|1. | Basis of Presentation
|-- | ---------------------

The accompanying unaudited
condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States for interim financial information and pursuant to the rules and regulations of the Securities and
Exchange Commission (SEC). Accordingly, they do not include all of the information and footnotes required by accounting principles generally accepted in the United States for complete financial statements. In the opinion of management, all
adjustments (consisting of normal recurring adjustments) considered necessary for a fair presentation have been included. Operating results for the three and six month periods ended April 30, 2008 are not necessarily indicative of the results
that may be expected for the year ending October 31, 2008; however, the Company expects to incur a substantial loss for the year ending October 31, 2008.

Effective October 2, 2007, the Companys outstanding and reserved class A common shares, including shares reserved for issuance on exercise of stock options and warrants, reverse split at a one-for-five
ratio, with post split shares retaining a par value of $.01 per share. All references to shares, options and warrants have been adjusted to reflect the reverse split for all periods presented.

The accompanying consolidated financial statements include the accounts of the Company and its wholly-owned subsidiaries, Biopure Netherlands, BV, Biopure
South Africa, Pty, Ltd., Reperfusion Systems Incorporated, DeNovo Technologies Corporation and Biopure Overseas Holding Company, and NeuroBlok Incorporated, a 60% owned subsidiary. All intercompany accounts and transactions have been eliminated in
consolidation.

These financial statements should be read in conjunction with the audited consolidated financial statements and notes
thereto included in the Companys Annual Report on Form 10-K for the fiscal year ended October 31, 2007, filed with the SEC on January 29, 2008.

The Company has financed operations from inception primarily through sales of equity securities and development and license agreement payments. The Company has not been profitable since inception and had an
accumulated deficit of $572.4 million at April 30, 2008. On November 6, 2007, the Company completed a public offering of its common stock and warrants that raised $16.5 million, for net proceeds to the Company of $14.9 million. The Company sold
19,377,500 new shares of its Class A common stock at $0.85 per share to institutional and individual investors and issued to these investors warrants to purchase 19,377,500 shares of its common stock at an exercise price of $1.0625 per share. As of
April 30, 2008, the Company had $5.7 million in cash and cash equivalents. The Company expects this funding to be sufficient to fund operations into July 2008 under the current operating plan. The Company will require significant additional
funding to remain a going concern and to fund operations until such time, if ever, as it becomes profitable. The Company is seeking additional capital and reducing costs. However, there can be no assurance that adequate additional financing will be
available to the Company on terms that it deems acceptable, if at all.

The Company may not continue to qualify for continued listing on the
Nasdaq Capital Market. To maintain its listing, the Company is required, among other things, to maintain a daily closing bid price per share of $1.00. The Company is out of compliance with the $1.00 minimum bid price requirement for continued
inclusion of its class A common stock in the Nasdaq Stock Market. The Company was provided with 180 calendar days, or until June 11, 2008, to regain compliance with the minimum bid price requirement. On June 12, 2008, the Company received
notice from Nasdaq that because it was not compliant with the minimum bid price requirement, but did meet all other listing criteria for the Nasdaq Capital Market, it had an additional 180 calendar days, or until December 8, 2008, to regain
compliance with the minimum bid price requirement. If the Company does not regain compliance with the minimum bid price requirement by December 8, 2008, Nasdaq will provide written notification that the securities will be delisted. If that
occurs, the Companys ability to raise funds will be adversely affected. These conditions raise substantial doubt about the Companys ability to continue as a going concern. The financial statements do not include any adjustments to
reflect the possible future effects on the recoverability and classification of assets or the amounts and classification of liabilities or any other adjustments that might be necessary should the Company be unable to continue as a going concern.

Comprehensive loss approximated net loss for all periods presented.



|2. | Net Loss per Share
|-- | ------------------

Basic net loss per common share is
computed based on the weighted-average number of common shares outstanding during the period. Diluted net loss per common share is computed based upon the weighted-average number of common shares outstanding during the period, adjusted for the
dilutive effect of the Companys common stock equivalents, including the maximum number of shares issuable upon the conversion of class B common stock outstanding, if any, and the exercise of class A common stock options and warrants. The
dilutive effect of stock options and warrants is determined based on the treasury stock method using the average market price of the class A common



6



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stock for the period. However, basic and diluted net loss per common share are presented as the same for all periods presented, as the Company had losses for
all periods presented, so the effect of class B common stock and options and warrants for class A common stock is anti-dilutive. Consequently, dilutive weighted average shares outstanding do not include 32,350,353 common-equivalent shares for the
three and six months ended April 30, 2008 and 12,041,148 potential common-equivalent shares for the three and six months ended April 30, 2007, as their effect would have been anti-dilutive.



|3. | Stock Based Compensation
|-- | ------------------------

As of April 30, 2008, the
Company had two share-based compensation plans, the Biopure Corporation 2008 Incentive Plan (the 2008 Plan) and the 2002 Biopure Corporation Omnibus Securities and Incentive Plan (the 2002 Plan). The Plans, as amended, which
are both shareholder-approved, permit the grant of share options to the Companys employees, consultants and directors for up to 8,343,328 shares of common stock. Option awards are generally granted with an exercise price equal to the
market price of the Companys stock at the date of grant. Typically, granted options vest in annual increments over four years and may be exercised within seven or ten years of the date of grant. Options to the non-employee members of the board
of directors vest monthly over one year. Shares issued upon exercise of options are generally issued from new shares of the Company.

The
Company adopted the provisions of Statement of Financial Accounting Standards 123(R), Share-Based Payment (SFAS 123(R)), beginning November 1, 2005, using the modified prospective transition method. Under the modified
prospective transition method, financial statements for periods prior to the adoption date are not retrospectively adjusted. However, compensation expense is recognized, based on the requirements of SFAS 123(R), for (a) all share-based
payments granted after the effective date and (b) all awards granted to employees prior to the effective date that remained unvested on the effective date.

Prior to adopting SFAS 123(R), the Company used the intrinsic value method to account for stock-based compensation under Accounting Principles Board Opinion No. 25, Accounting for Stock Issued to
Employees. As a result of the adoption of SFAS 123(R), the Company is amortizing the unamortized stock-based compensation expense related to unvested option grants issued prior to the adoption of SFAS 123(R). Historically the fair
value of options granted was calculated using the Black-Scholes Option pricing model. The Company has elected to continue to use this model. SFAS 123(R) also requires companies to use an estimated forfeiture rate when calculating the expense
for the period, while SFAS 123 permitted companies to record forfeitures based on actual forfeitures, which was the Companys historical policy. The Company has applied an estimated forfeiture rate to remaining unvested awards based on
historical experience in determining the expense recorded in the Companys consolidated statement of operations. This estimate is evaluated quarterly and the forfeiture rate is adjusted as necessary. Ultimately, the actual expense recognized
over the vesting period will only be for those shares that vest. The Company has elected to recognize compensation cost for awards with pro-rata vesting using the straight-line method.

The fair value of each stock option is estimated on the date of grant using the Black-Scholes option pricing model with the assumptions noted in the
following table. The weighted average risk-free interest rate is based on a treasury instrument, the term of which is consistent with the expected life of the stock options. Expected volatility is based exclusively on historical volatility data of
the Companys common stock. The Company estimates stock option forfeitures based on historical experience. The Company was unable to use historical information to estimate the expected term due to a lack of historical exercise activity and
therefore used the simplified method as prescribed by the SEC Staff Accounting Bulletin (SAB) No. 107 for grants prior to December 31, 2007. On December 21, 2007 the SEC issued SAB No. 110, which states the staff will
continue to accept, under certain circumstances, the use of the simplified method beyond December 31, 2007. The Company is continuing to use the simplified method.



|                                         |  |                    |   |  |                  |   |  |               |   |  |               |  
|---------------------------------------- |  | ------------------ | - |  | ---------------- | - |  | ------------- | - |  | ------------- | -
|                                         |  | Three Months Ended |   |  | Six Months Ended |  
|                                         |  | April 30,2008      |   |  | April 30,2007    |   |  | April 30,2008 |   |  | April 30,2007 |  
|Weighted average risk-free interest rate |  | 2.76               | % |  | 4.58             | % |  | 2.76          | % |  | 4.58          | %
|Expected volatility                      |  | 85                 | % |  | 85               | % |  | 85            | % |  | 85            | %
|Expected lives (years)                   |  | 5.42               |   |  | 5.42             |   |  | 5.42          |   |  | 5.42          |  
|Expected dividend yield                  |  | 0                  | % |  | 0                | % |  | 0             | % |  | 0             | %

During the first six months of fiscal 2008 and 2007, approximately 229,000 and 265,000 options,
respectively, were granted with a weighted average grant-date fair value of $0.30 and $0.39 per share, respectively.

During the first six
months of fiscal 2008, approximately $353,000 of stock based compensation expense was recorded related to options granted compared to $414,000 during the same period last year. As of April 30, 2008, there was approximately $764,000 of
unrecognized compensation expense, net of forfeitures, related to non-vested market-based share awards, which is expected to be recognized over a weighted-average period of 2.06 years.



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No options were exercised during the first six months of fiscal 2008 or fiscal 2007. The total fair value
of shares vested during the first six months of fiscal 2008 and 2007 were $222,479 and $68,000, respectively.



|4. | Inventories
|-- | -----------

Inventories are valued at the lower of cost
(determined using the first-in, first-out method) or market. Inventories were as follows at the following dates:



|                         |  |                |       |                  |   |      
|------------------------ |  | -------------- | ----- | ---------------- | - | -----
|In thousands             |  | April 30, 2008 |       | October 31, 2007
|Raw materials            |  | $              | 522   |                  | $ | 641  
|Work-in-process          |  |                | 1,130 |                  |   | 468  
|Finished goods-Oxyglobin |  |                | 1,187 |                  |   | 732  
|Finished goods-Hemopure  |  |                | 317   |                  |   | 278  
|                         |  |                |       |                  |   |      
|                         |  | $              | 3,156 |                  | $ | 2,119
|                         |  |                |       |                  |   |      

Hemopure [hemoglobin glutamer  250 (bovine)] finished goods represents units the Company
expects to sell in South Africa and units to be used in preclinical or clinical trials conducted by or on behalf of the U.S. Naval Medical Research Center (NMRC), for which the Company is reimbursed. Each quarter the Company reviews the inventory of
Hemopure finished goods and, if necessary, writes off any units beyond those forecasted for these purposes. There was no write-down of inventory in the second fiscal quarter of 2008. If the Company continues to experience extremely limited sales in
South Africa or further delays in the use of Hemopure by the NMRC, it could expect to write off additional units in the future.



|5. | Accrued Expenses
|-- | ----------------

Accrued expenses were as follows at the
following dates:



|                                              |  |                |       |                  |   |      
|--------------------------------------------- |  | -------------- | ----- | ---------------- | - | -----
|In thousands                                  |  | April 30, 2008 |       | October 31, 2007
|Accrued payroll and related employee expenses |  | $              | 286   |                  | $ | 373  
|Financing fees                                |  |                | 537   |                  |   | 537  
|Accrued legal and audit fees                  |  |                | 231   |                  |   | 347  
|Accrued vacation                              |  |                | 332   |                  |   | 291  
|Accrued utilities                             |  |                | 159   |                  |   | 164  
|Clinical trials                               |  |                | 320   |                  |   | 199  
|Other                                         |  |                | 605   |                  |   | 601  
|                                              |  |                |       |                  |   |      
|                                              |  | $              | 2,470 |                  | $ | 2,512
|                                              |  |                |       |                  |   |      

During the second fiscal quarter of 2008 the Company paid approximately $29,000 representing the
remainder of severance payments owed to the Companys former Vice President-Operations and Acting Chief Financial Officer, who resigned in early fiscal 2008.



|6. | Other Current Assets
|-- | --------------------

During fiscal 2006, management
identified certain manufacturing equipment that the Company was not using and did not expect to be able to use in the future, resulting in a decision by management to pursue selling this equipment. Early in fiscal 2007 the Company determined that
the held for sale criteria in FASB Statement No. 144, Accounting for the Impairment or Disposal of Long-Lived Assets, had been met. Accordingly, the carrying value of the manufacturing equipment of $225,000 has been recorded
separately within other current assets on the Companys condensed consolidated balance sheets as of April 30, 2008 and October 31, 2007. The carrying amount was determined based on quoted market prices for similar assets, less costs
to sell. The Company did not recognize any gains or losses during the quarter ended April 30, 2008 related to this asset.



|7. | Commitments and Contingencies
|-- | -----------------------------

Research Agreement(1)

In 2003, the Company entered into a Cooperative Research and Development Agreement (CRADA) with the
NMRC. Under the CRADA, as amended, the NMRC took primary responsibility for designing, seeking U.S. Food and Drug Administration (FDA) acceptance of, and conducting a clinical trial of Hemopure in trauma patients with severe hemorrhagic shock (acute
blood loss) in the out-of-hospital setting. To date, the U.S. Congress has appropriated a total of $22.5 million to the Department of Defense for the development of Hemopure in potential civilian and military trauma applications,(2)of which approximately $1.6 million was reverted due to delays in initiating the RESUS clinical trial. If there are additional delays in the start of the
proposed clinical trial, additional funds could be reverted in the



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future. The funding is to be used for the Navys proposed clinical trial and has supported preclinical studies of the product in animal models of
hemorrhagic shock (acute blood loss), including those that mimic military trauma scenarios. The funding has also been used to reimburse company expenses of supporting the trauma program. In addition, the NMRC paid approximately $1.2 million for
inventory purchases to be delivered in the future, recorded in the accompanying consolidated balance sheet as deferred revenue. If the NMRC were to decide not to continue to pursue the RESUS project described in the CRADA, the Company could be
required to return the $1.2 million.



|8. | Litigation
|-- | ----------

The seven members of the Companys Board
of Directors during the period March through December 2003 and certain officers during that period were named as defendants in two stockholder derivative actions filed on January 26, 2004 and January 29, 2004 in the U.S. District Court for
the district of Massachusetts. A consolidated, amended complaint was filed in regard to Biopure Corporation Derivative Litigation. Biopure is named as a defendant, even though in a derivative action, any award is for the benefit of the Company, not
individual stockholders. The consolidated, amended complaint alleges that the individual directors and officers breached fiduciary duties in connection with disclosures concerning regulatory and clinical events. The complaint does not specify an
amount of alleged damages. The Company appointed two disinterested directors as a special litigation committee to determine whether or not the Company should pursue this action. The special litigation committee conducted its investigation and
determined the Company should not pursue the action. The special litigation committee accordingly filed a motion to dismiss the action. No amounts have been accrued to date with regard to this litigation and a similar claim in the Trial Court of
Middlesex County in Massachusetts. The Company believes this case is without merit.



|9. | Income Taxes
|-- | ------------

On November 1, 2007, the Company
adopted Financial Accounting Standard Board (FASB) Interpretation No. 48 (FIN 48), Accounting for Uncertainty in Income Taxesan interpretation of FASB Statement No. 109, which clarifies the accounting for
uncertainty in income taxes recognized in an enterprises financial statements in accordance with FASB Statement No. 109, Accounting for Income Taxes. FIN 48 prescribes a recognition threshold and measurement criteria for the financial
statement recognition and measurement of a tax position taken or expected to be taken in a tax return. FIN 48 also provides guidance on derecognition, classification, interest and penalties, accounting in interim periods, disclosure, and transition
and defines the criteria that must be met for the benefits of a tax position to be recognized.

As of the adoption of FIN 48, the
Companys total unrecognized tax benefit is $278,000. This unrecognized tax benefit primarily relates to research and development tax credits. Of this amount, $278,000 represents the amount of unrecognized tax benefits that, if recognized,
would affect the effective tax rate prior to the adjustment for the Companys valuation allowance. As a result of the implementation of FIN 48, the Company did not recognize an increase in tax liability for the unrecognized tax benefits because
the Company has recorded a tax net operating loss carryforward that would offset any liability. The use of net operating losses may be subject to limitations under IRC Section 382.

As of April 30, 2008, the balance of unrecognized tax benefits is $278,000. There were no significant changes to these amounts during the three- or
six-month periods ended January 31, 2008 and April 30, 2008, respectively. The Company does not believe there will be any material changes in its unrecognized tax positions over the next 12 months.

Utilization of the net operating loss and research and development credit carryforwards may be subject to a substantial annual limitation under
Section 382 of the Internal Revenue Code of 1986 due to ownership change limitations that may have occurred previously or that could occur in the future. These ownership changes may limit the amount of net operating loss and research and
development credit carryforwards that can be utilized annually to offset future taxable income and tax, respectively. There also could be additional ownership changes in the future which may result in additional limitations in the utilization of the
carryforward net operating losses and credits.

The Companys policy is to recognize interest and penalties related to unrecognized tax
benefits and income tax liabilities, when applicable, as part of income tax expense in its consolidated statement of operations. Since a full valuation allowance was recorded against the Companys net deferred tax assets and the unrecognized
tax benefits determined under FIN 48 would not result in a tax liability, the Company has not accrued for any interest and penalties relating to these unrecognized tax benefits as of April 30, 2008.



|(1) | The content of this document does not necessarily reflect the position or the policy of the U.S. Government or the Department of Defense, and no official endorsement should be
inferred of the Navy. Biopure collaborative clinical development program for Hemopure in trauma is contingent upon funding.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | $5,102,306 is from Grant DAMD17-02-1-0697. The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering
acquisition office.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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As of April 30, 2008, the Company and its subsidiaries are subject to United States federal income
tax, as well as income tax of multiple state income and foreign jurisdictions. Tax years ended October 31, 2004, 2005 and 2006 remain subject to examination by major tax jurisdictions, which are Federal and the Commonwealth of Massachusetts.
However, since the Company has net operating loss and tax credit carryforwards which may be utilized in future years to offset taxable income, those years may also be subject to review by relevant taxing authorities if utilized.



|10. | Recently Issued Accounting Standards
|--- | ------------------------------------

In August 2007, the
FASB issued Proposed FASB Staff Position (FSP) APB Opinion No. 14-a, Accounting for Convertible Debt Instruments That May Be Settled in Cash upon Conversion (Including Partial Cash Settlement). This FSP applies to convertible debt
instruments that, by their stated terms, may be settled in cash (or other assets) upon conversion, including partial cash settlement, unless the embedded conversion option is required to be separately accounted for as a derivative under FASB
Statement No. 133. The liability and equity components of convertible debt instruments within the scope of this FSP must be separately accounted for in a manner that will reflect the entitys nonconvertible debt borrowing rate when
interest cost is recognized in subsequent periods. This FSP is effective for financial statements issued for fiscal years beginning after December 15, 2008, and interim periods within those fiscal years (beginning with the Companys 2010
fiscal year). This FSP must be applied retrospectively to all periods presented. For convertible debt instruments that were modified after their original issuance date to provide for cash settlement upon conversion in a modification transaction that
was not accounted for as an extinguishment, this FSP must be applied retrospectively to the modification date. The Company has not evaluated the impact, if any, that the adoption of APB Opinion No. 14-a will have on its consolidated financial
statements.

In December 2007, the FASB issued SFAS No. 160, Noncontrolling Interests in Consolidated Financial Statements. This
Statement establishes accounting and reporting standards that require the ownership interests in subsidiaries non-parent owners be clearly presented in the equity section of the balance sheet; requires the amount of consolidated net income
attributable to the parent and to the noncontrolling interest be clearly identified and presented on the face of the consolidated statement of income; requires that changes in a parents ownership interest while the parent retains its
controlling financial interest in its subsidiary be accounted for consistently; requires that when a subsidiary is deconsolidated, any retained noncontrolling equity investment in the former subsidiary be initially measured at fair value and the
gain or loss on the deconsolidation of the subsidiary be measured using the fair value of any noncontrolling equity; requires that entities provide disclosures that clearly identify the interests of the parent and the interests of the noncontrolling
owners. This Statement is effective as of the beginning of an entitys first fiscal year that begins after December 15, 2008. The Company has not determined the impact, if any, SFAS No. 160 will have on its financial statements.

In March 2008, the Financial Accounting Standards Board (FASB) issued Statement of Financial Accounting Standards
(SFAS) No. 161, Disclosures about Derivative Instruments and Hedging Activities, an amendment of FASB Statement No. 133 (SFAS 161), which requires enhanced disclosures about (i) how and why an
entity uses derivative instruments, (ii) how derivative instruments and related hedged items are accounted for under SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities, as amended (SFAS 133)
and its related interpretations, and (iii) how derivative instruments and related hedged items affect an entitys financial position, financial performance, and cash flows. SFAS No. 161 also requires that objectives for using
derivative instruments be disclosed in terms of underlying risk and accounting designation and requires cross-referencing within the footnotes. This statement also suggests disclosing the fair values of derivative instruments and their gains and
losses in a tabular format. This statement is effective for financial statements issued for fiscal years and interim periods beginning after November 15, 2008 and therefore is effective for our second quarter in fiscal 2009. The Company has not
evaluated the impact, if any, that the adoption of SFAS 161 will have on its consolidated financial statements.



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BIOPURE CORPORATION

Managements Discussion and Analysis of

Financial Condition and Results of Operations

April 30, 2008



|Item 2. | Managements Discussion and Analysis of Financial Condition and Results of Operations
|------- | -------------------------------------------------------------------------------------

Cautionary Statement Regarding Forward-Looking Information

The following discussion of the Companys financial
condition and results of operations includes forward-looking statements. These forward-looking statements include, without limitation, statements about the clinical development program, expected activities as the Company pursues its business plan,
and the adequacy of its available cash resources. Forward-looking statements include those that imply that the Company will be able to manage its expenses effectively and raise the funds needed to continue its business, that the Company will be able
to stabilize and enhance its financial position, that the Company will be able to commercially develop Hemopure, that in pursuing anemia, cardiovascular and trauma indications the Company will be able to address safety and efficacy questions of
regulatory agencies, that the U.S. Naval Medical Research Center (NMRC) may conduct a clinical trial in trauma patients, and that anticipated milestones will be met in the expected timetable or at all, that any preclinical or clinical trials
will be successful, that Hemopure, if it receives regulatory approval, will attain market acceptance and be manufactured and sold in amounts to attain profitability and that the Company will be able to successfully increase its manufacturing
capacity for Hemopure if it receives regulatory approval. Forward-looking statements are usually accompanied by words such as believe, anticipate, plan, seek, expect, intend and
similar expressions. The forward-looking information is based on various factors and was derived using numerous assumptions and judgments.

Actual results
may differ materially from those set forth in the forward-looking statements due to risks and uncertainties that exist in the Companys operations and business environment. These risks include the factors identified under Risk
Factors in this report. All forward-looking statements included or incorporated by reference in this report are based on information available to the Company on the date such statements were made. In light of the substantial risks and
uncertainties inherent in all future projections, the inclusion of forward-looking statements in this report should not be regarded as representations by us that the Companys objectives or plans will be achieved. The Company undertakes no
obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise. You are advised, however, to consult any additional disclosures the Company makes in its reports to the SEC on
Forms 10-Q, 8-K and 10-K.

The content of this document does not necessarily reflect the position or the policy of the U.S. Government or the
Department of Defense, and no official endorsement should be inferred.

Overview

Since its founding in 1984, Biopure has been primarily a research and development company focused on developing Hemopure, the Companys oxygen therapeutic for human use, and obtaining regulatory approval in the
United States and other markets. The Companys research and development expenses have been devoted to basic research, product development, process development, preclinical studies, clinical trials and regulatory activity. In addition, the
Companys development expenses in the past included the design, construction, validation and maintenance of a large-scale pilot manufacturing plant in Cambridge, Massachusetts.

A manufacturing facility is a necessary part of developing a product like Hemopure. The FDA classifies Hemopure as a biologic because it is derived from animal-source material. Unlike drugs that are chemical
compounds, biologics are defined by their manufacturing process and composition. Under FDA regulations, any change in the manufacturing process could be considered to produce an altered, possibly different product. Therefore, it is necessary to
demonstrate manufacturing capability at greater than laboratory scale for an application for regulatory approval of a biologic to be accepted for review. This requirement has resulted in high manufacturing research and development costs in the
development of our products relative to other types of drugs and high costs in keeping the manufacturing facility operational.

Prior to 1998, the Company
manufactured product solely for use in preclinical and clinical trials, and production costs were charged wholly to research and development. As an offshoot of the research and development for Hemopure, Oxyglobin, a similar product, gained marketing
approval for veterinary use in the U.S. in 1998 and in the European Union in 1999. Following the U.S. approval, Oxyglobin was produced for sale in the same pilot manufacturing plant that was built and maintained primarily for the development of
Hemopure. Because of this marketing approval, costs of production of Oxyglobin for sale and an allocation of manufacturing overhead based on capacity used for Oxyglobin are charged to inventory and to cost of revenues. Since marketing approval of
Hemopure for human use was granted in South Africa in 2001, costs of production of Hemopure for sale and an allocation of manufacturing overhead based on capacity used for Hemopure have been charged to inventory and to cost of revenues.



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Thus a substantial majority of our costs comprise research and development and cost of revenues. The revenues from
products we now market defray some of the manufacturing costs we must incur to keep our plant operational as we manufacture Hemopure for clinical trials and maintain readiness for greater volume manufacturing. We also receive governmental
reimbursements of research and development costs for development of Hemopure for use in trauma.

Our research and development activities in 2007 and 2008
include the clinical trials described below.

Ischemia

Biopure is conducting Phase 2 clinical trials of Hemopure in Europe and South Africa to assess the products potential safety and feasibility in ischemia applications, such as cardiac surgery and acute coronary ischemia (e.g., heart
attack). The primary goal of these trials is to provide preliminary data to support advanced trials in heart attack patients. In contrast to trials where Hemopure was administered as a red blood cell replacement, in these ischemia trials, Hemopure
is being administered as an oxygen-carrying drug.

Trauma

The Company has been working with the NMRC to develop Hemopure for use in trauma patients in out-of-hospital settings (for example, at accident scenes, in ambulances or on the battlefield). In June 2005, the NMRC
submitted an IND application to the FDA for a clinical trial called RESUS (Restore Effective Survival in Shock). The application, which has been on clinical hold at the FDA since July 2005, proposes a government-funded, NMRC sponsored clinical trial
to assess the safety and efficacy of out-of-hospital administration of Hemopure in reducing morbidity and mortality in severely injured patients experiencing hemorrhagic shock (acute blood loss).

In order for RESUS to proceed, the FDA must lift the clinical hold, and the Department of Defense and the internal review boards of participating hospitals in the
communities where the study would take place must provide final authorization.

The Company sponsored a separate Phase 2, 50-patient clinical trial at the
Johannesburg Hospital Trauma unit in South Africa that is designed to assess the safety and tolerability of Hemopure in the hospital emergency room setting for treatment of unstable trauma patients who have significant blood loss and low blood
pressure. Of 50 planned patients, as of June 9, 2008, 33 patients had been enrolled. On that date the Company terminated the trial for several reasons, including cost and slow enrollment. The Company had already reported interim data on 22
patients to regulatory agencies and intends to report the balance when final data are available.

Surgical Anemia Marketing Application

In July 2006, the Company submitted a marketing authorization application (MAA) to the United Kingdoms Medicines and Healthcare products
Regulatory Agency (MHRA). The application sought authorization to market Hemopure in the U.K. for the treatment of acutely anemic adult orthopedic surgery patients less than 80 years of age.

In December 2006, the Company received a provisional opinion letter from the United Kingdom Commission on Human Medicines containing comments and questions based on the
MHRAs review of our MAA. The Company met with the MHRA during 2007 and responded in full to its letter in early November 2007, requesting market authorization for the treatment of acutely anemic adult orthopedic surgery patients less than
80 years of age when blood is not readily available or not an option. In April 2008 the Company received a comment letter from the U.K.s Commission on Human Medicines addressing the Companys application. The comment letter states
that the Commission was reassured on a number of the clinical questions raised in its initial opinion letter, but indicated that both major and other pharmacological and clinical issues either were not yet resolved by the
Companys submission made in November 2007 or were only resolved in part. In addition the comment letter poses several new questions. The Company met with the MHRA on May 29, 2008 to discuss manufacturing and quality issues. The Company
expects to meet with the MHRA again for clarification of the remaining issues, and intends to request a meeting in July.

Compassionate Use

As of May 27, 2008 Hemopure has been administered to 24 patients since January 2007 in the U.S. on a compassionate use basis for
the treatment of life-threatening anemia when blood transfusion was not an option. The FDA granted a single patient IND in each of these emergency situations and approved treatment for an additional 16 patients where the product was not
administered. Prior to these cases, there had been no compassionate use of the product since 2000. A manuscript reporting on 54 compassionate use cases has been prepared, and the Company is submitting it for publication.



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Significant Estimates and Assumptions

The preparation of financial statements in conformity with accounting principles generally accepted in the United States requires management to make significant estimates and assumptions that affect the reported
amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting periods. Significant estimates and assumptions by management
affect accrued expenses, stock-based compensation, long-lived assets and inventory valuation.

Although the Company regularly assesses these estimates,
actual results could differ materially from these estimates. Changes in estimates are recorded in the period in which they occur. The Company bases its estimates on historical experience and various other assumptions that it believes to be
reasonable under the circumstances.

Critical Accounting Policies

The Companys significant accounting policies are described in the Notes to the Consolidated Financial Statements contained in its Annual Report on Form 10-K for the fiscal year ended October 31, 2007. The
application of the Companys critical accounting policies is particularly important to the accurate portrayal of its financial position and results of operations. These critical accounting policies require the Company to make subjective
judgments in determining estimates about the effect of matters that are inherently uncertain. The following critical accounting policies are considered most significant:

Inventories

Inventories are stated at the lower of cost (determined using the first-in, first-out method) or market.
Inventories consist of raw material, work-in-process and finished Hemopure and Oxyglobin. Inventories are reviewed periodically to identify expired units and units with a remaining life too short to be commercially viable based on projected sales
activity, including sales of Hemopure for use in the proposed RESUS clinical trial. Inventories are also subject to internal quality compliance investigations. Inventory that is not expected to be utilized based on projected demand or fails quality
assessment is written off. The inventory of Hemopure finished goods represents the units the Company expects to sell in South Africa or use in preclinical and clinical studies where payment is received for the trial material. The Company has been
and expects to continue to be paid for the units to be used in a proposed trauma trial to be conducted by or on behalf of the NMRC and in preclinical studies by or under the guidance of the NMRC. Any units expected to be consumed by the Company in
its own preclinical or clinical trials are expensed to research and development when manufactured.

Stock-Based Compensation

The Company adopted the provisions of Statement of Financial Accounting Standards 123R, Share-Based Payment (SFAS 123R), beginning
November 1, 2005, using the modified prospective transition method. SFAS 123R requires the Company to measure the cost of employee services in exchange for an award of equity instruments based on the grant-date fair value of the award and to
recognize cost over the requisite service period. Option valuation models require the input of subjective assumptions, including stock price volatility and expected term of options.

Revenue Recognition

The Company recognizes revenue from sales of Hemopure and Oxyglobin in accordance with Staff
Accounting Bulletin (SAB) No. 104, Revenue Recognition, whereby sales are recorded upon shipment, provided that there is evidence of a final arrangement, there are no uncertainties surrounding acceptance, title has
passed, collectibility is probable and the price is fixed or determinable. Hemopure sales in South Africa are primarily to hospitals in both the private and government sectors. The Company sells Oxyglobin directly to a distributor in the United
Kingdom for resale in the European Union. Through the second fiscal quarter of 2008 the Company sold Oxyglobin directly to veterinarians in the United States. Beginning in May 2008 the Company is selling Oxyglobin directly to a distributor in the
United States for resale in the U.S. Collectibility is reasonably assured once pricing arrangements are established, as these agreements establish the distributors intent to pay. The Company monitors creditworthiness on a regular basis and
believes collectibility of product revenues is reasonably assured at the time of sale. The Company recognizes revenue from the U.S. military upon invoicing for reimbursable expenses in connection with developing Hemopure for a trauma indication.
Amounts received for prepaid inventory purchases, recorded as deferred revenue, will not be recognized as sales until shipment.



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Results of Operations

As the Company generates net losses, the key drivers of the losses are cost of revenues, research and development and general and administrative expenses. Inflation and changing prices have not had a significant impact on the revenues or
loss from operations in the periods presented below. For the three month and six month periods ended April 30, 2008 and 2007, these items were as follows (dollars in thousands):



|                                  |  |                    |       |                       |                  |   |        |                |                       |  |                |        |  |                       |        |  |        |   |                       |   |        |  |     |  
|--------------------------------- |  | ------------------ | ----- | --------------------- | ---------------- | - | ------ | -------------- | --------------------- |  | -------------- | ------ |  | --------------------- | ------ |  | ------ | - | --------------------- | - | ------ |  | --- | -
|                                  |  | Three Months Ended |       |                       | Six Months Ended |  
|                                  |  | April 30, 2008     |       |                       | April 30, 2007   |   |        | April 30, 2008 |                       |  | April 30, 2007 |       
|                                  |  | Amount             |       | Percent ofTotal Costs |                  |   | Amount |                | Percent ofTotal Costs |  |                | Amount |  | Percent ofTotal Costs |        |  | Amount |   | Percent ofTotal Costs |  
|Oxyglobin Product Sales           |  | $                  | 777   |                       |                  |   |        | $              | 500                   |  |                |        |  | $                     | 1,196  |  |        |   |                       | $ | 944    |  |     |  
|Hemopure Product Sales            |  |                    | 89    |                       |                  |   |        |                | 6                     |  |                |        |  |                       | 147    |  |        |   |                       |   | 22     |  |     |  
|Research and Development Revenues |  |                    | 36    |                       |                  |   |        |                | 113                   |  |                |        |  |                       | 132    |  |        |   |                       |   | 247    |  |     |  
|Other Revenues                    |  |                    |      |                       |                  |   |        |                |                      |  |                |        |  |                       |       |  |        |   |                       |   |       |  |     |  
|                                  |  |                    |       |                       |                  |   |        |                |                       |  |                |        |  |                       |        |  |        |   |                       |   |        |  |     |  
|Total Revenues                    |  |                    | 902   |                       |                  |   |        |                | 619                   |  |                |        |  |                       | 1,475  |  |        |   |                       |   | 1,213  |  |     |  
|Cost of Revenues                  |  |                    |       |                       |                  |   |        |                |                       |  |                |        |  |                       |        |  |        |   |                       |   |        |  |     |  
|Oxyglobin                         |  |                    | 645   |                       | 11               | % |        |                | 643                   |  | 9              | %      |  |                       | 1,214  |  | 10     | % |                       |   | 1,462  |  | 10  | %
|Hemopure                          |  |                    | 1,168 |                       | 20               | % |        |                | 2,132                 |  | 30             | %      |  |                       | 3,387  |  | 27     | % |                       |   | 4,475  |  | 30  | %
|                                  |  |                    |       |                       |                  |   |        |                |                       |  |                |        |  |                       |        |  |        |   |                       |   |        |  |     |  
|Total Cost of Revenues            |  |                    | 1,813 |                       | 31               | % |        |                | 2,775                 |  | 39             | %      |  |                       | 4,601  |  | 37     | % |                       |   | 5,937  |  | 40  | %
|Research and Development          |  |                    | 1,756 |                       | 29               | % |        |                | 1,864                 |  | 27             | %      |  |                       | 3,243  |  | 26     | % |                       |   | 3,779  |  | 26  | %
|Sales and Marketing Oxyglobin     |  |                    | 48    |                       | 0                | % |        |                | 21                    |  | 0              | %      |  |                       | 73     |  | 0      | % |                       |   | 40     |  | 0   | %
|Hemopure                          |  |                    | 400   |                       | 7                | % |        |                | 345                   |  | 5              | %      |  |                       | 655    |  | 5      | % |                       |   | 718    |  | 5   | %
|                                  |  |                    |       |                       |                  |   |        |                |                       |  |                |        |  |                       |        |  |        |   |                       |   |        |  |     |  
|Total Sales and Marketing         |  |                    | 448   |                       | 7                | % |        |                | 366                   |  | 5              | %      |  |                       | 728    |  | 5      | % |                       |   | 758    |  | 5   | %
|General and Administrative        |  |                    | 1,947 |                       | 33               | % |        |                | 2,027                 |  | 29             | %      |  |                       | 3,948  |  | 32     | % |                       |   | 4,258  |  | 29  | %
|                                  |  |                    |       |                       |                  |   |        |                |                       |  |                |        |  |                       |        |  |        |   |                       |   |        |  |     |  
|Total Costs                       |  | $                  | 5,964 |                       | 100              | % |        | $              | 7,032                 |  | 100            | %      |  | $                     | 12,520 |  | 100    | % |                       | $ | 14,732 |  | 100 | %

Three months ended April 30, 2008 compared to three months ended April 30, 2007

Total revenues for the second fiscal quarter of 2008 were $902,000, including $777,000 from sales of Oxyglobin, $89,000 from sales of Hemopure in
South Africa and $36,000 from funds received from the U.S. Government. Total revenues for the same period in 2007 were $619,000, including $500,000 from Oxyglobin sales, $6,000 from sales of Hemopure and $113,000 from the U.S. Government. The
increase in Hemopure sales reflects the Companys marketing efforts and increasing use of the product in South Africa.

Oxyglobin revenues increased
during the second fiscal quarter of 2008 compared to the same period in 2007 primarily due to higher unit sales to the Companys European distributor. During the second fiscal quarter of 2007, the Company accounted for European sales on a
consignment basis. Now the European distributor buys product for its inventory upon shipment by the Company. In the U.S., a higher average selling price of Oxyglobin during the second fiscal quarter of 2008 offset lower unit sales compared to the
same period in fiscal 2007. The Company believes the lower unit sales in the current period are a result of two price increases implemented during fiscal 2007 without concurrent marketing activity. Effective May 14, 2008, the Company appointed
an exclusive distributor for the United States. The U.S. distributor buys product for resale, like the European distributor. Consequently, beginning with the third fiscal quarter of 2008, the Company anticipates that comparisons with comparable
quarters of previous periods will show the effect of the change, but does not anticipate that the distributorship will result in a material difference in financial results.

Cost of revenues includes costs of both Oxyglobin and Hemopure. Cost of revenues was $1.8 million for the second quarter of fiscal 2008, compared to $2.8 million for the same period in 2007. Increased manufacturing
during the second fiscal quarter of 2008 compared to the same period in 2007 resulted in lower unabsorbed manufacturing costs charged to cost of revenues.

The Companys major research and development programs and related expenses are as follows (dollars in thousands):



|                 |  |                    |     |                           |                |   |        |   |                           |  |    |  
|---------------- |  | ------------------ | --- | ------------------------- | -------------- | - | ------ | - | ------------------------- |  | -- | -
|                 |  | Three Months Ended |    
|                 |  | April 30, 2008     |     |                           | April 30, 2007 |  
|                 |  | Amount             |     | Percent ofTotal R&D Costs |                |   | Amount |   | Percent ofTotal R&D Costs | 
|Ischemia Program |  | $                  | 438 |                           | 25             | % |        | $ | 798                       |  | 43 | %
|Trauma Program   |  |                    | 223 |                           | 13             |   |        |   | 489                       |  | 26 |  

Historically, virtually all research and development expenses related to an anticipated surgical anemia indication
where Hemopure would be used to eliminate or reduce the need for red blood cell transfusion. Biopure is seeking U.K. approval, but is not currently seeking FDA approval, for this indication.



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##### Table of Contents

The Companys primary operating focus is now the development of Hemopure for ischemia and trauma indications,
discussed below.

Both the ischemia and the trauma projects are in early stages (i.e., safety clinical trials and preclinical animal studies). Cumulative
ischemia project expenditures of $7.6 million as of April 30, 2008 consist primarily of the costs of preparing and carrying out Phase 2 clinical trials in Europe. Cumulative trauma expenditures of $5.8 million as of April 30, 2008 consist
of costs to conduct preclinical studies and preparation costs primarily associated with protocol design and preparation of the IND application for the proposed NMRC sponsored out-of-hospital trauma trial. Of these trauma expenses, $3.0 million has
been reimbursed to date by payments administered by the U.S. Army from funds described in Note 7 to the condensed consolidated financial statements.

Regulatory agency requirements for additional clinical trials and any further preclinical studies that might be necessary for either an ischemia indication or for use in trauma patients cannot be estimated at this time. The risks and
uncertainties associated with the early stage of planning and execution of the ischemia and trauma clinical development programs include, among other things, uncertainties about results that at any time could require us to abandon or greatly modify
either project. Accordingly, the Company cannot estimate the period in which material net cash inflows for either of these two projects might commence, if ever, and it does not expect to obtain marketing approval of a potential ischemia indication
or trauma indication for several years.

Research and development expenses were $1.8 million for the second quarter of fiscal 2008 compared to $1.9 million
for the same period in 2007. A $328,000 reduction in spending on clinical and preclinical trials during the second fiscal quarter of 2008 was partially offset by a $207,000 increase in spending on outside services.

Sales and marketing expenses increased to $448,000 for the second quarter of fiscal 2008, from $366,000 for the same period in 2007. This increase is primarily due to
increased activities in South Africa.

General and administrative expenses were $2.0 million for the second fiscal quarters of 2008 and 2007. Insurance
premiums and occupancy costs decreased during the second fiscal quarter of 2008 compared to the same period in 2007, and employee related costs and fees for consultants increased.

In May 2008 the Company implemented cost deductions, including a workforce reduction. These measures represent anticipated future savings of approximately $1.2 million annually in manufacturing, research and
development and administrative expenses. The Company expects to identify and implement additional cost reductions.

Six months ended April 30,
2008 compared to six months ended April 30, 2007

Total revenues for the first six months of fiscal year 2008 were $1.5 million including $1.2
million from sales of Oxyglobin, $147,000 from sales of Hemopure in South Africa and $132,000 from funds received from the U.S. Government. Total revenues for the same period in 2007 were $1.2 million including $944,000 from Oxyglobin sales, $22,000
from sales of Hemopure and $247,000 from the U.S. Government. The increase in Hemopure sales reflects the Companys marketing efforts and increasing use of the product in South Africa. Oxyglobin revenues increased during the first six months of
fiscal 2008 compared to the same period in 2007 primarily due to higher unit sales to the companys European distributor and to higher average selling prices in the U.S. Sales in Europe increased during the first six months of fiscal 2008
compared to the same period last year due to the change in selling arrangement explained above. In the U.S., the higher average selling price of Oxyglobin offset lower unit sales compared to the same period in fiscal 2007.

Cost of revenues includes costs of both Oxyglobin and Hemopure. Cost of revenues was $4.6 million for the first six months of fiscal 2008, compared to $5.9 million for
the same period in 2007. Increased manufacturing during the first six months of 2008 compared to the same period in 2007 resulted in lower unabsorbed manufacturing costs charged to cost of revenues.

The Companys major research and development programs and related expenses are as follows (dollars in thousands):



|                 |  |                  |       |                           |                |   |        |   |                           |  |    |  
|---------------- |  | ---------------- | ----- | ------------------------- | -------------- | - | ------ | - | ------------------------- |  | -- | -
|                 |  | Six Months Ended |      
|                 |  | April 30, 2008   |       |                           | April 30, 2007 |  
|                 |  | Amount           |       | Percent ofTotal R&D Costs |                |   | Amount |   | Percent ofTotal R&D Costs | 
|Ischemia Program |  | $                | 1,069 |                           | 33             | % |        | $ | 1,239                     |  | 43 | %
|Trauma Program   |  |                  | 415   |                           | 13             |   |        |   | 1,144                     |  | 26 |  

Research and development expenses were $3.2 million for the first six months of fiscal 2008 compared to $3.8
million for the same period in 2007. During the first six months of fiscal 2007 the company spent $659,000 on preclinical studies, which were completed during the same year, with no comparable studies being conducted in fiscal 2008. This decrease
was partially offset by a net increase of $190,000 in salaries and other employee related expenses due to increased headcount.



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Sales and marketing expenses decreased to $728,000 for the first six months of fiscal 2008 compared to $758,000 for the
same period fiscal 2007. The decrease is primarily attributable to expenses related to a U.K. medical advisory board meeting concerning the U.K. market, held in fiscal 2007, for Hemopure. Increased marketing efforts for Hemopure in South Africa and
an increase in the allocation of resources for Oxyglobin in the U.S. partially offset the decrease in expenses.

General and administrative expenses were
$3.9 million for the first six months of fiscal 2008 compared to $4.3 million for the same period in fiscal 2007. This decrease is primarily due to a $339,000 reduction in consulting and legal fees during the first six months of fiscal 2008.

Liquidity and Capital Resources

At April 30,
2008, the Company had $5.7 million in cash and cash equivalents. The Company believes this amount will be sufficient to fund operations into July 2008. The Company will require significant additional funding to remain a going concern and to fund
operations until such time, if ever, as it becomes profitable. In May 2008 the Company implemented cost reductions, including a workforce reduction. These measures represent overall anticipated future savings of approximately $1.2 million annually.
The Company is working to identify additional cost reductions. However, there can be no assurance that additional cost reductions will be identified nor that any additional financing will be available to the Company on terms that it deems
acceptable, if at all. If additional financing or an alternative transaction is not available when needed or is not available on acceptable terms, we may be unable to successfully develop or commercialize Hemopure or to continue to operate.

Net cash used in operating activities decreased $428,000 in the first six months of fiscal 2008 compared to the corresponding period in fiscal 2007. Cash
used in operating activities was $11.0 million for the first six months of fiscal 2008, which included a net loss of $10.7 million, decreased by non-cash charges for depreciation and amortization and by compensation expense related to the issuance
of stock options. Inventories consumed $1.0 million during the first six months of fiscal 2008 largely due to increased production.

Cash provided by
financing activities includes approximately $14.9 million in net proceeds raised during the first six months of fiscal 2008 through sales of common stock and warrants.



|Item 3. | Quantitative and Qualitative Disclosure About Market Risk
|------- | ---------------------------------------------------------

We
currently have minimal foreign currency exchange risks, primarily associated with expenses for clinical trial, regulatory and sales and marketing activities outside of the United States and sales in South Africa. We sell Oxyglobin in Europe in
U.S. dollars. The distributor bears the risk of foreign currency exchange fluctuation. We sell Hemopure in South Africa in local currency. Fluctuations in revenues in South Africa are largely offset by fluctuations in our local expenses.
Dramatic fluctuations in exchange rates could result in either increases or decreases in unit sales, as the effective unit price to the distributor and the customer would vary. We invest our cash and cash equivalents in money market funds. These
investments are subject to interest rate risk. However, due to the nature of our short-term investments, we believe that the interest rate risk exposure is not material.



|Item 4. | Controls and Procedures
|------- | -----------------------



|(a) | Evaluation of Disclosure Controls and Procedures.
|--- | -------------------------------------------------

Under the supervision
and with the participation of the Companys management, including its Chief Executive Officer and Chief Financial Officer, the Company conducted an evaluation of the effectiveness of its disclosure controls and procedures (as defined in Rules
13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the Exchange Act)) as of the end of the period covered by this report. Based on this evaluation, the Chief Executive Officer and the Chief Financial Officer
concluded that the Companys disclosure controls and procedures were effective as of the end of the period covered by this report to ensure that information required to be disclosed by the Company in its Exchange Act reports is recorded,
processed, summarized and reported within the time periods specified in SEC rules and forms.



|(b) | Changes in Internal Control Over Financial Reporting.
|--- | -----------------------------------------------------

There have been no
changes in the Companys internal control over financial reporting (as defined under Rules 13a-15(f) or 15d-15(f) of the Exchange Act) during its most recently completed fiscal quarter that have materially affected, or are reasonably likely to
materially affect, its internal control over financial reporting.



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BIOPURE CORPORATION

Part IIOther Information

April 30, 2008



|Item 1. | Legal Proceedings
|------- | -----------------

The information in Note 8 to the Condensed
Consolidated Financial Statements is incorporated herein by reference.



|Item 1A. | Risk Factors
|-------- | ------------

Company Risks

We have a history of losses and expect future losses.

We have had annual losses from operations since our inception. In the fiscal years ended October 31, 2005, 2006 and 2007, we had losses from operations of $29.1 million, $26.9 million and
$36.9 million, respectively. We had an accumulated deficit of $572.4 million as of April 30, 2008. We anticipate that we will continue to generate losses for the next several years. Even if Hemopure were to be approved by the FDA or
we obtain marketing authorization in another major market, we might not be able to achieve profitable operations.

We could fail to
remain a going concern.

We expect that our cash on hand and forecasted sales will fund operations into July 2008. Additional funds
may not be available to us thereafter or on terms that we deem acceptable, if they are available at all. Our former independent registered public accounting firm modified their report for our fiscal year ended October 31, 2007 with respect to
our ability to continue as a going concern. We expect that our current independent registered public accounting firm will do likewise.

This type of modification typically would indicate that our recurring losses from operations and current lack of sufficient funds to sustain operations through the end of the following fiscal year raise substantial doubt about our ability
to continue as a going concern. Our consolidated financial statements have been prepared on the basis of a going concern, which contemplates the realization of assets and the satisfaction of liabilities in the normal course of business. If we became
unable to continue as a going concern, we would have to liquidate our assets and we might receive significantly less than the values at which they are carried on our consolidated financial statements. Any shortfall in the proceeds from the
liquidation of our assets would directly reduce the amounts, if any, that holders of our common stock could receive in liquidation.

To
remain a going concern, we require significant funding. The inclusion of a going concern modification in Ernst & Young LLPs audit opinion for fiscal 2007 may materially and adversely affect our stock price and our ability to
raise new capital.

We could fail in financing efforts if we fail to receive stockholder approval when needed.

We are required under the Nasdaq Marketplace Rules to obtain stockholder approval for any issuance of additional equity securities that would comprise
more than 20% of our total shares of common stock outstanding before the issuance of the securities at a discount to the greater of book or market value in an offering that is not deemed to be a public offering by Nasdaq. If we remain
listed on Nasdaq, funding of our operations in the future may require stockholder approval for purposes of complying with the Nasdaq Marketplace Rules. We could require such approval to raise additional funds, but might not be successful in
obtaining any such required stockholder approval. If we remain listed on Nasdaq and we fail to obtain approval prior to a financing for which the Nasdaq believes we need stockholder approval, we may be delisted.

Failure to raise sufficient additional funds will significantly impair or possibly cause us to cease the development, manufacture and sale of our
products and our ability to operate.

The development and regulatory processes for seeking and obtaining regulatory approval to
market Hemopure have been and will continue to be costly. We will require substantial working capital to develop, manufacture and sell Hemopure and to finance our operations until such time, if ever, as we can generate positive cash flow. If
Hemopure is approved for sale in the U.S. or the European Union, we expect that we will need to increase our manufacturing capacity, for which we will require significant additional funding. If additional financing is not available when needed
or is not available on acceptable terms, we may be unable to successfully develop or commercialize Hemopure or to continue to operate. A sustained period in which financing is not available could force us to go out of business. If the U.S. Navy
does not continue its development of Hemopure for a trauma indication, we will likely cease development of Hemopure for that indication because of limited resources.



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If we fail to obtain FDA approval to market Hemopure, we will be highly adversely affected.

We will not be able to market Hemopure in the U.S. unless and until we receive FDA approval. As a prerequisite to further
clinical trials for Hemopure in the U.S., we must address ongoing FDA questions. We have been delayed, and could be further delayed, in responding, either by outside contractors failure or inability to complete their tasks in a timely manner,
our own staff limitations or by other unanticipated delays or difficulties and lack of resources. The FDA to date has found inadequate the responses of the NMRC to questions raised in connection with its proposal to conduct a trial of Hemopure in
trauma patients in the out-of-hospital setting. If the FDA finds future responses made by us or the NMRC to be inadequate, we would be unable to pursue indefinitely development of Hemopure in the U.S., a very large, key market.

Furthermore, even if we adequately address the FDAs questions, we will need to obtain FDA acceptance of the protocols for, and to complete, human
clinical trials before applying for FDA authorization to market Hemopure. We cannot predict whether or when we will be able to commence a U.S. clinical trial of Hemopure or that we will be able to conduct or satisfactorily conclude additional
clinical trials required to obtain FDA marketing approval.

In the case of the trauma indication, the NMRC has primary responsibility for
designing, seeking FDA acceptance of and conducting a clinical trial of Hemopure for out-of-hospital treatment of trauma patients in hemorrhagic shock. In 2005, it proposed a two-stage Phase 2b/3 clinical trial, which was placed on an FDA clinical
hold. The FDAs Blood Products Advisory Committee in December 2006 recommended that the trial be redesigned as a Phase 2 trial. The NMRC submitted a Phase 2 protocol, which continues to be on clinical hold. The FDA may not approve the
redesigned Phase 2 trial. If the FDA ultimately lifts the clinical hold and the RESUS trial, as it may be redesigned, is commenced and concluded, the trial results may not lead to FDA marketing approval for the proposed trauma indication because of
poor outcome or need for additional trials. Usually a Phase 2 trial is not adequate for market approval.

In addition, future or existing
governmental action or changes in FDA policies or precedents may result in delays or rejection of an application for marketing authorization. The FDA has considerable discretion in determining whether to grant marketing authorization for a drug and
may delay or deny authorization even in circumstances where the applicants clinical trials have proceeded in compliance with FDA procedures and regulations and have met the established end points of the trials. Despite all of our efforts, the
FDA could refuse to grant marketing authorization for Hemopure for any indication.

Challenges to FDA determinations are generally time
consuming and costly, and rarely succeed. We can give no assurance that we will obtain FDA marketing authorization for Hemopure for any indication. The failure to obtain any authorization would have severe adverse consequences.

If we fail to obtain regulatory approvals in foreign jurisdictions, we will not be able to market Hemopure abroad.

We are seeking marketing authorization in the U.K. and we intend to seek to market Hemopure in other international markets, including other European Union
countries. Whether or not FDA marketing authorization has been obtained, we must obtain separate regulatory authorizations in order to market our products in the European Union and many other foreign jurisdictions. The regulatory processes differ
among these jurisdictions, and the time needed to secure marketing authorization may be even longer than that required for FDA authorization. Marketing authorization in any one jurisdiction does not ensure authorization in a different jurisdiction.
As a result, obtaining foreign authorizations will require additional expenditures and significant amounts of time. We can give no assurance that we will obtain marketing authorization for Hemopure in any foreign jurisdiction other than that already
obtained in South Africa.

Clinical trials are extremely costly and subject to numerous risks and uncertainties.

To gain authorization from the FDA and European regulatory authorities for the commercial sale of any product, including Hemopure,
we must demonstrate in clinical trials, and thereby satisfy the regulatory authorities as to, the safety and efficacy of the product. Clinical trials are expensive and time-consuming. Clinical trials are also subject to numerous risks and
uncertainties not within our control. For example, data we obtain from preclinical and clinical studies are susceptible to varying interpretations that can impede regulatory approval.

In addition, many factors could delay or result in termination of ongoing or future clinical trials. Results from ongoing or completed preclinical or
clinical studies or analyses could raise concerns, real or perceived, over the safety or efficacy of an investigational pharmaceutical. We cannot assure investors that the FDA will not delay the development of Hemopure by further continuing its
current hold or placing other clinical trials we sponsor or others may sponsor on hold in the future. A clinical trial may also be delayed by slow patient enrollment. There may be limited availability of patients who meet the criteria for certain
clinical trials. Delays in planned patient enrollment can result in increased development costs and delays in regulatory approvals. Further, we rely on investigating physicians and the hospital trial sites to enroll patients. In addition, patients
may experience adverse medical events or side effects resulting in delays, whether or not the events or the side effects relate to our product.



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If we do not have the financial resources to fund trials required to develop Hemopure for multiple
potential indications, our success will be adversely affected.

In general, we cannot sell Hemopure for any indication unless we
receive regulatory approval for that indication. Regulatory authorities generally require a separate marketing authorization for each proposed indication for the use of a drug. In order to market Hemopure for more than one indication, we will have
to design additional clinical trials, submit the trial designs to applicable regulatory authorities for review and complete those trials successfully. If any regulatory authority approves Hemopure for an indication, it may require a label cautioning
against the products use for indications or classes of patients for which it has not been approved. We may not have funds available to try to exploit Hemopure for all of its potential indications. Our potential revenues will be impaired by
limitations on the marketing of Hemopure.

If the Navy were to abandon its attempt to develop Hemopure for a trauma indication, it
would have a serious adverse effect on our prospects.

Our current clinical development activities involve the pursuit of two
indications: ischemia and trauma, and we are beginning to develop a possible anemia indication not involving the replacement of red blood cells. We are pursuing trauma in the U.S. because the NMRC has agreed to be responsible for virtually all
aspects of an advanced trauma trial. The FDA has prevented the start of a proposed NMRC trial since June 2005. If the Navy were to decide not to continue to pursue this project, we would not have the benefit of this alliance and would be required to
delay indefinitely work on a trauma indication.

If we cannot retain the personnel we need or if we cannot hire or retain highly
qualified people, our operations will suffer.

We may experience the loss of personnel, including executives and other employees, as
a result of attrition, which we have previously experienced. We expect that in the future we will need to recruit and retain personnel for important positions. We may be unable to do so, in particular if we are unable to improve our financial
position.

If we cannot generate adequate, profitable sales of Hemopure, we will not be successful.

To succeed, we must develop Hemopure commercially and sell adequate quantities of Hemopure at a profit. We may not accomplish either of these objectives.
To date, we have focused our efforts on developing Hemopure . Uncertainty exists regarding the potential size of any geographic market for Hemopure and the price that we can charge for it. In addition to population, the size of the market will be
affected by the indication(s) for which Hemopure is approved and will be greatly reduced if reimbursement for the cost of Hemopure is not available from health insurance companies or government programs.

If we cannot find appropriate marketing partners, we may not be able to market and distribute Hemopure effectively.

Our success depends, in part, on our ability to market and distribute Hemopure effectively in major markets. We have no experience in the sale or
marketing of medical products for humans in a major market. In the event that we obtain FDA authorization or European marketing authorization for Hemopure, we may choose initially to market Hemopure using an independent distributor. Any such
distributor:



| |  |  | might not be successful in marketing Hemopure;
| | - |  | ----------------------------------------------



| |  |  | might, at its discretion, limit the amount and timing of resources it devotes to marketing Hemopure; and/or
| | - |  | -----------------------------------------------------------------------------------------------------------



| |  |  | might terminate its agreement with us and abandon our products at any time whether or not permitted by the applicable agreement.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------

We may instead seek an alternative arrangement, such as an alliance with a pharmaceutical company, or may be required to recruit, train and retain a
marketing staff and sales force of our own. We may not be successful in obtaining satisfactory distributorship agreements or entering into alternative arrangements.

If we cannot obtain market acceptance of Hemopure, we will not be able to generate adequate, profitable sales.

Even if we succeed in obtaining marketing authorization for Hemopure in one or more major markets, a number of factors may affect future sales of our product. These factors include:



| |  |  | whether and how quickly physicians and third party payers accept Hemopure as a cost-effective therapeutic;
| | - |  | ----------------------------------------------------------------------------------------------------------



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| |  |  | whether medical care providers or the public accept the use of a bovine-derived protein as a therapeutic, particularly in light of public perceptions in the U.S.,
Europe and elsewhere about the risk of mad cow disease; and
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | product price, which we believe has been an important factor in South Africa and may be elsewhere.
| | - |  | --------------------------------------------------------------------------------------------------

If we fail to comply with good manufacturing practices, we may not be able to sell our products.

To obtain the authorization of the FDA and European regulatory authorities to sell Hemopure, we must demonstrate to them that we can manufacture Hemopure
in compliance with applicable good manufacturing practices, commonly known as GMPs. GMPs are stringent requirements that apply to all aspects of the manufacturing process. We are subject to inspections by the FDA and European regulatory authorities
at any time to determine whether we are in compliance with GMP requirements. If we fail to manufacture in compliance with GMPs, these regulatory authorities may refuse to authorize the marketing of Hemopure or revoke the authorizations to market
Oxyglobin or may take other enforcement actions with respect to Hemopure or Oxyglobin.

The manufacturing process for Hemopure is
complicated and time-consuming, and we may experience problems that would limit our ability to manufacture and sell Hemopure.

Our
products are biologic drugs and require product manufacturing steps that are more complicated, time consuming and costly than those required for most chemical drugs. Minor deviations in our manufacturing processes or other problems could result in
unacceptable changes in the products that result in lot failures, increased production scrap, shipment delays, regulatory problems, product recalls or product liability, all of which could negatively affect our results of operations.

If we were unable to use our manufacturing facilities in Massachusetts or Pennsylvania, we would be unable to manufacture for an extended period of
time.

We manufacture at a single location in Massachusetts with raw material sourcing and initial processing in Pennsylvania.
Damage to either of these manufacturing facilities due to fire, contamination, natural disaster, power loss or other events could cause us to cease manufacturing. For example, if our Massachusetts manufacturing facility were destroyed, it would take
approximately two years or more to rebuild and qualify it. In the reconstruction period, we would not be able to manufacture product and thus would have no supply of Hemopure for research and development, clinical trials or sales after we used up
all finished goods in our inventory. A new manufacturing facility would take longer to construct.

If Hemopure receives marketing
authorization in a major market, we will be required to expand our manufacturing capacity to develop our business, which will require substantial third-party financing. Failure to increase our manufacturing capacity and to lower our manufacturing
cost per unit may impair market acceptance of Hemopure and prevent us from achieving profitability.

If we are permitted to market
Hemopure for indications with high demand in one or more markets, we will need to construct new manufacturing capacity to develop our business. The increase in our manufacturing capacity is dependent upon our obtaining substantial financing from
third parties. Third parties can be expected to be unwilling to commit to finance a new manufacturing facility so long as we do not have marketing authorization in a major market. We cannot assure that sufficient financing for new manufacturing
capacity will be available or, if available, will be on terms that are acceptable to us. After the required significant financing was in place, it would take at least 30 to 36 months from groundbreaking to build a large Hemopure manufacturing
facility and to qualify and obtain facility approval from the FDA or European regulatory authorities.

If Hemopure is approved for
marketing in a major market and receives market acceptance, we could experience difficulty manufacturing enough of the product to meet demand. The manufacturing processes we currently employ to produce small quantities of material for research and
development activities and clinical trials may not be successfully scaled up for production of commercial quantities at a reasonable cost or at all. We will face risks in the scale-up of our processes in the construction of any new manufacturing
facility, and in turn could encounter delays, higher than usual rejects, additional reviews and tests of units produced and other costs attendant to an inability to manufacture saleable product. Furthermore, scale-up might not succeed in lowering
our product cost, which also could negatively affect our results of operations. If we cannot manufacture sufficient quantities of Hemopure, we may not be able to build our business or operate profitably. In addition, if we cannot fill orders for
Hemopure, customers might turn to alternative products and may choose not to use Hemopure even after we have addressed any capacity shortage.



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Our lack of operating history makes evaluating our business difficult.

Proceeds from the sales of equity securities, payments to fund our research and development activities, licensing fees, and interest income have provided
almost all of our funding to date. We have no adequate history of selling Hemopure upon which to base an evaluation of our business and prospects.

If we are not able to protect our intellectual property, competition could force us to lower our prices, which might reduce profitability.

We believe that our patents, trademarks and other intellectual property rights, including our proprietary knowledge, are important to our success. Accordingly, the success of our business will depend, in part, upon
our ability to defend our intellectual property against infringement by third parties. We cannot guarantee that our intellectual property rights will protect us adequately from competition from similar products. Some of our important patents have
relatively short remaining terms. Nor can we guarantee that additional products or processes we discover or seek to commercialize will receive adequate intellectual property protection.

In addition, third parties may successfully challenge our intellectual property. We have not filed patent applications in every country. In certain
countries, obtaining patents for our products, processes and uses may be difficult or impossible. Patents issued in regions other than the U.S. and Europe may be harder to enforce than, and may not provide the same protection as, patents
obtained in the U.S. and Europe.

Failure to avoid infringement of others intellectual property rights could impair our
ability to manufacture and market our products.

We cannot guarantee that our products and manufacturing process will be free of
claims by third parties alleging that we have infringed their intellectual property rights. Several third parties hold patents with claims to compositions comprising polymerized hemoglobin and their methods of manufacture and use. One or more of
these third parties may assert that our activities infringe claims under an existing patent. Any such claim could be expensive and time-consuming to defend, and an adverse litigation result or a settlement of litigation could require us to pay
damages, obtain a license from the complaining party or a third party, develop non-infringing alternatives or cease using the challenged intellectual property. Any such result could be expensive or result in a protracted plant shutdown, in turn
adversely affecting our ability to operate profitably.

There can be no assurance that we would prevail in any intellectual property
infringement action, or be able to obtain a license to any third-party intellectual property on commercially reasonable terms, to successfully develop non-infringing alternatives on a timely basis, or to license alternative non-infringing
intellectual property, if any exists, on commercially reasonable terms. Any significant intellectual property impediment to our ability to develop and commercialize Hemopure would seriously harm our business and prospects.

Our operating results will be adversely affected if we incur product liability claims in excess of our insurance coverage.

The testing and marketing of medical products, even after regulatory approval, have an inherent risk of product liability. We maintain limited product
liability insurance coverage. Our profitability would be adversely affected by a successful product liability claim in excess of our insurance coverage. We cannot guarantee that product liability insurance in adequate coverage amounts will be
available in the future or be available on terms we could afford to pay.

Replacing our sole- source suppliers for key materials
could result in unexpected delays and expenses.

We obtain some key materials, including membranes and chemicals, and services from
sole-source suppliers. All of these materials are commercially available elsewhere. If such materials were no longer available at a reasonable cost from our existing suppliers, we would need to purchase substitute materials from new suppliers. If we
needed to locate a new supplier, the substitute or replacement materials or facilities would need to be tested for equivalency. Such equivalency tests could significantly delay product development, or delay or limit commercial sales of approved
products and cause us to incur additional expense.

We obtain bovine hemoglobin from one abattoir, from animals raised in several states of
the U.S. We cannot predict the future effect, if any, on us of the spread of bovine spongiform encephalopathy (mad cow disease) in the U.S. Any quarantine affecting herds that supply us or a shutdown of the abattoir that we use
could have a material adverse effect on us, as we would have to find, validate and obtain regulatory approval of new sources of supply or new facilities.



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Provisions of our restated certificate of incorporation and by-laws could impair or delay
stockholders ability to replace or remove our management and could discourage takeover transactions that a stockholder might consider to be in its best interest.

Provisions of our restated certificate of incorporation and by-laws, as well as our stockholder rights plan, could impede attempts by stockholders to
remove or replace our management or could discourage others from initiating a potential merger, takeover or other change of control transaction, including a potential transaction at a premium over market price that a stockholder might consider to be
in its best interest. In particular:



| |  |  | Our restated certificate of incorporation does not permit stockholders to take action by written consent and provides for a classified board of directors, and our
by-laws provide that stockholders who wish to bring business before an annual meeting of stockholders or to nominate candidates for election of directors at an annual meeting of stockholders must deliver advance notice of their proposals to us
before the meeting. These provisions could make it more difficult for a party to replace our board of directors by requiring two annual stockholder meetings to replace a majority of the directors, making it impossible to remove or elect directors by
written consent in lieu of a meeting and making it more difficult to introduce business at meetings.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Our stockholder rights plan may have the effect of discouraging any person or group that wishes to acquire more than 20% of our Class A common stock from doing
so without obtaining our agreement to redeem the rights. If our agreement to redeem the rights is not obtained, the acquiring person or group would suffer substantial dilution. Consequently, the possible acquirer would likely not complete a
transaction that stockholders might consider to be in their best interest.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Industry Risks

Intense competition could harm our financial performance.

The biotechnology and pharmaceutical industries are highly competitive. There are a number of companies, universities and research organizations actively engaged in research and development of products that may be
similar to, or alternatives to, Hemopure for trauma, ischemia or anemia indications. We are aware that one public company competitor, Northfield Laboratories Inc., has completed a pivotal trial of a hemoglobin-based oxygen carrier produced from
human blood that has passed its expiration date for human transfusion, and has stated its intention to file a BLA in 2008. We are also aware that other companies are conducting preclinical studies and clinical trials of hemoglobin-based or
perfluorocarbon oxygen carriers. The products being developed by these companies are intended for use in humans and as such could compete, if authorized for marketing by regulatory authorities, with Hemopure. We may also encounter competition in
ischemia indications from medical devices and drugs on the market or currently under development.

Competition could diminish our ability
to become profitable or affect our profitability in the future. Our existing and potential competitors:



| |  |  | are conducting clinical trials of their products;
| | - |  | -------------------------------------------------



| |  |  | have or may be able to access substantially greater resources than we have and be better equipped to develop, manufacture and market their products;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | may have their products authorized for marketing prior to Hemopure; and
| | - |  | -----------------------------------------------------------------------



| |  |  | may develop superior technologies or products rendering our technology and products non-competitive or obsolete.
| | - |  | ----------------------------------------------------------------------------------------------------------------

Stringent, ongoing government regulation and inspection of our facilities could lead to delays in the manufacture, marketing and sale of our
products.

The FDA and foreign regulatory authorities continue to regulate products even after they receive marketing authorization.
Even if Hemopure is being marketed, the manufacture and marketing of Hemopure will be subject to ongoing regulation, including compliance with current good manufacturing practices, adverse event reporting requirements and general prohibitions
against promoting products for unapproved or off-label uses. We would also be subject to inspection and market surveillance by the FDA and foreign regulatory authorities for compliance with these and other requirements. We are subject to
such regulation, inspection and surveillance in South Africa. Any enforcement action resulting from failure, even by inadvertence, to comply with these requirements could affect the manufacture and marketing of Hemopure. In addition, the FDA or
foreign regulatory authorities could withdraw a previously approved product from the applicable market(s) upon receipt of newly discovered information. Furthermore, the FDA or foreign regulatory authorities could require us to conduct additional,
and potentially expensive, studies in areas outside our approved indications. Moreover, unanticipated changes in existing regulations or the adoption of new regulations could affect and make more expensive the continued manufacturing and marketing
of our products.



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Health care reform and controls on health care spending may limit the price we can charge for
Hemopure and the amount we can sell.

The federal government and private insurers have considered ways to change, and have changed,
the manner in which health care services are provided in the U.S. Potential approaches and changes in recent years include controls on health care spending and the creation of large purchasing groups. In the future, it is possible that the
government may institute price controls and limits on Medicare and Medicaid spending. These controls and limits might affect the payments we collect from sales of our products. European governments generally control expenditures on medicines through
price control and other restrictive practices. Assuming we succeed in bringing Hemopure to market, uncertainties regarding future health care reform and private market practices would affect our ability to sell Hemopure in large quantities at
profitable pricing in the U.S. and abroad.

Uncertainty of third-party reimbursement could affect our profitability.

Sales of medical products largely depend on the reimbursement of patients medical expenses by governmental health care programs and
private health insurers. Even if Hemopure marketing is authorized, there is no guarantee that governmental health care programs or private health insurers would reimburse for purchases of Hemopure, or reimburse a sufficient amount to permit us to
sell Hemopure at high enough prices to generate a profit. Hemopure sales in South Africa are being adversely affected by a lack of third-party reimbursement.

Investment Risks

The Nasdaq Capital Market may cease to list our Class A common stock, and delisting may cause
the value of an investment in our Company to substantially decrease.

We may be unable to meet the listing requirements of the
Nasdaq Capital Market in the future. To maintain our listing, we are required, among other things, to maintain a daily closing bid price per share of $1.00. On December 14, 2007, we received notice from the Nasdaq Stock Market that the closing
bid price of our Class A common stock had fallen below and remained below $1.00 for 30 consecutive business days. As a result, we are out of compliance with the $1.00 minimum bid price requirement for continued inclusion of our Class A
common stock in the Nasdaq Capital Market. We were provided with 180 calendar days, or until June 11, 2008, to regain compliance with the minimum bid price requirement. On June 12, 2008, we received notice from Nasdaq that because we were
not compliant with the minimum bid price requirement, but did meet all other listing criteria for the Nasdaq Capital Market, we have an additional 180 calendar days, or until December 8, 2008, to regain compliance with the minimum bid price
requirement by having the bid price of our Class A common stock close at $1.00 per share or more for at least 10 consecutive business days. If we do not regain compliance with the minimum bid price requirement by December 8, 2008, Nasdaq
will provide written notification that our Class A common stock will be delisted.

Delisting would adversely affect the trading price
and limit the liquidity of our common stock and therefore could cause the value of an investment in our Company to decrease.

As we
sell additional shares, our stock price may decline as a result of the dilution which will occur to existing stockholders.

Until we
are profitable, we will need significant additional funds to develop our business and sustain our operations. Any additional sales of shares of our common stock are likely to have a dilutive effect on some or all of our then existing stockholders.
Resales of newly issued shares in the open market could also have the effect of lowering our stock price, thereby increasing the number of shares we may need to issue in the future to raise the same dollar amount and consequently further diluting
our outstanding shares.

The perceived risk associated with the possible sale of a large number of shares could cause some of our
stockholders to sell their stock, thus causing the price of our stock to decline. In addition, actual or anticipated downward pressure on our stock price due to actual or anticipated sales of stock could cause some institutions or individuals to
engage in short sales of our common stock, which may itself cause the price of our stock to decline.

We may be unable to raise additional
capital. A sustained inability to raise capital could force us to go out of business. Significant declines in the price of our common stock could also impair our ability to attract and retain qualified employees, reduce the liquidity of our common
stock and result in the delisting of our common stock from the Nasdaq Stock Market.



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Shares eligible for future sale may cause the market price for our common stock to drop
significantly, even if our business is doing well.

We cannot predict the effect, if any, that future sales of our common stock or
the availability of shares for future sale will have on the market price of our common stock from time to time. Shares of our common stock issued in the future, including shares issued upon exercise of outstanding options and warrants, may become
available for resale in the public market from time to time, and the market price of shares of our common stock could drop significantly if the holders of these shares sell them or are perceived by the market as intending to sell them.

Our stock price has been and may continue to be highly volatile; volatility may adversely affect holders of our stock and our ability to raise
capital.

The trading price of our common stock has been and is likely to continue to be extremely volatile. During the period from
November 1, 2004 to April 30, 2008, the trading price of our stock ranged from a low of $0.31 per share (on April 7, 2008) to a high of $23.10 per share (on January 4, 2005). Our stock price and trading volume could be
subject to wide fluctuations in response to a variety of factors including, but not limited to, the following:



| |  |  | failure to identify and hire key personnel or the loss of key personnel;
| | - |  | ------------------------------------------------------------------------



| |  |  | an inability to obtain or the perception that we will be unable to obtain adequate financing to fund our operations;
| | - |  | --------------------------------------------------------------------------------------------------------------------



| |  |  | FDA or U.K. action or delays in FDA or U.K. action on Hemopure or competitors products;
| | - |  | ----------------------------------------------------------------------------------------



| |  |  | publicity regarding actual, perceived or potential medical issues relating to products under development by us or our competitors;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



| |  |  | actual or potential preclinical or clinical trial results relating to products under development by us or our competitors;
| | - |  | --------------------------------------------------------------------------------------------------------------------------



| |  |  | delays in our testing and development schedules;
| | - |  | ------------------------------------------------



| |  |  | announcements of technological innovations or new products by our competitors;
| | - |  | ------------------------------------------------------------------------------



| |  |  | developments or disputes concerning patents or proprietary rights;
| | - |  | ------------------------------------------------------------------



| |  |  | regulatory developments in the U.S. and foreign countries;
| | - |  | ----------------------------------------------------------



| |  |  | economic and other factors, as well as period-to-period fluctuations in our financial results;
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | market conditions for pharmaceutical and biotechnology stocks; and
| | - |  | ------------------------------------------------------------------



| |  |  | additional, future communications from the Nasdaq Stock Market concerning delisting or potential delisting.
| | - |  | -----------------------------------------------------------------------------------------------------------

External factors may also adversely affect the market price for our common stock. The price and liquidity of our common stock may be significantly
affected by the overall trading activity and market factors affecting small capitalization biotechnology stocks generally.



|Item 2. | Unregistered Sales of Equity Securities and Use of Proceeds.
|------- | ------------------------------------------------------------

None



|Item 3. | Defaults Upon Senior Securities
|------- | -------------------------------

None



|Item 4. | Submission of Matters to a Vote of Security Holders
|------- | ---------------------------------------------------

(a) The
Company held its 2008 annual meeting of stockholders on March 27, 2008.

(b) The meeting involved the election of directors; see item (c) below.

(c) Each matter voted upon at the meeting, and the votes, were as follows:



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##### Table of Contents

|(i) | David N. Judelson and Guido J. Neels were elected as directors at the meeting. The other directors whose terms of office continued after the meeting are Zafiris G. Zafirelis, Jay B.
Pieper, Daniel P. Harrington, Allan Ferguson and C. Everett Koop, M.D. The shares voted for the election of directors were as follows:
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|                  |  |            |  |          
|----------------- |  | ---------- |  | ---------
|                  |  | For        |  | Withheld 
|David N. Judelson |  | 26,082,926 |  | 1,006,577
|Guido J. Neels    |  | 26,222,740 |  | 866,670  



|(ii) | The Biopure Corporation 2008 Incentive Plan was approved and the shares voted were as follows:
|---- | ----------------------------------------------------------------------------------------------



|          |  |         |  |        
|--------- |  | ------- |  | -------
|For       |  | Against |  | Abstain
|4,377,896 |  | 916,970 |  | 9,680  

There were no broker-held nonvoted shares represented at the meeting.



|Item 5. | Other Information.
|------- | ------------------

As previously disclosed, on December 14,
2007, we received notice from the Nasdaq Stock Market that the closing bid price of our Class A common stock had fallen below and remained below $1.00 per share for 30 consecutive business days. As a result, we are out of compliance with the
$1.00 minimum bid price requirement for continued inclusion of our Class A common stock in the Nasdaq Capital Market. We were provided with 180 calendar days, or until June 11, 2008, to regain compliance with the minimum bid price
requirement. On June 12, 2008, we received notice from the Nasdaq Stock Market that because we were not compliant with the minimum bid price requirement, but did meet all other listing criteria for the Nasdaq Capital Market set forth in
Marketplace Rule 4310(c), we have an additional 180 calendar days, or until December 8, 2008, to regain compliance with the minimum bid price requirement by having the bid price of our Class A common stock close at $1.00 per share or more
for at least 10 consecutive business days. If we do not regain compliance with the minimum bid price requirement by December 8, 2008, Nasdaq will provide written notification that our Class A common stock will be delisted. At that time, we
may appeal the staffs determination, but the staff has informed us that, historically, a near-term reverse stock split has been the only definitive plan acceptable to resolve a bid price deficiency. The staff also noted that our Class A
common stock may be delisted prior to December 8, 2008, if we fail to maintain compliance with any other listing requirement.



|Item 6. | Exhibits
|------- | --------

The exhibits are listed in the accompanying Exhibit
Index.



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##### Table of Contents

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.



|                    |  |                     |  |                                
|------------------- |  | ------------------- |  | -------------------------------
|                    |  | BIOPURE CORPORATION
|                    |  |                    
|Date: June 18, 2008 |  | By:                 |  | /s/ David A. Butler            
|                    |  |                     |  | David A. Butler                
|                    |  |                     |  | Interim Chief Financial Officer



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EXHIBIT INDEX



|         |  |                                                                                                 |  |         
|-------- |  | ----------------------------------------------------------------------------------------------- |  | --------
|Exhibits |  | Description                                                                                     |  | Location
|3 (i)    |  | Restated Certificate of Incorporation of Biopure, as amended                                    |  | (1)     
|3 (ii)   |  | By-laws of Biopure, as amended                                                                  |  | (2)     
|4.1      |  | Form of Selling Agent Warrants, dated April 23, 2002                                            |  | (3)     
|4.2      |  | Form of Underwriter Warrant, dated March 2003                                                   |  | (4)     
|4.3      |  | Form of Investor Warrant, dated April 2003                                                      |  | (4)     
|4.4      |  | Form of Underwriter Warrant, dated April 2003                                                   |  | (4)     
|4.5      |  | Underwriter Warrant dated, April 16, 2003                                                       |  | (5)     
|4.6      |  | Form of Investor Warrant, dated May 2, 2003                                                     |  | (4)     
|4.7      |  | Form of Investor Warrant, dated May 6, 2003                                                     |  | (4)     
|4.8      |  | Form of Investor Warrant, dated October 17, 2003                                                |  | (5)     
|4.9      |  | Form of Investor Warrant, dated February 19, 2004                                               |  | (5)     
|4.10     |  | Form of Investor Warrant, dated September 2004                                                  |  | (6)     
|4.11     |  | Form of Underwriter Warrant, dated September 2004                                               |  | (6)     
|4.12     |  | Form of Investor Warrant, dated December 14, 2004                                               |  | (7)     
|4.13     |  | Form of Underwriter Warrant, dated December 14, 2004                                            |  | (7)     
|4.14     |  | Form of Underwriter Warrants, dated January 10, 2005                                            |  | (8)     
|4.15     |  | Form of Consultant Warrant, dated July 29, 2005                                                 |  | (5)     
|4.16     |  | Form of Underwriter Warrant, dated December 2005                                                |  | (9)     
|4.17     |  | Amended Form of Investor Warrant, dated December 27, 2005                                       |  | (10)    
|4.18     |  | Amended Form of Underwriter Investor Warrant, dated December 27, 2005                           |  | (5)     
|4.19     |  | Form of Investor Warrant, dated January 2006                                                    |  | (5)     
|4.20     |  | Form of Underwriter Warrant, dated January 2006                                                 |  | (5)     
|4.21     |  | Form of Underwriter Investor Warrant, dated January 17, 2006                                    |  | (10)    
|4.22     |  | Form of Investor Warrant, dated August 23, 2006                                                 |  | (11)    
|4.23     |  | Form of Underwriter Warrant, dated August 23, 2006                                              |  | (11)    
|4.24     |  | Form of Underwriter Investor Warrant, dated August 23, 2006                                     |  | (10)    
|4.25     |  | Form of Investor Warrant, dated December 2006                                                   |  | (12)    
|4.26     |  | Form of Underwriters Investor Warrant, dated December 13, 2006                                 |  | (12)    
|4.27     |  | Form of Underwriters Warrant, dated December 13, 2006                                          |  | (12)    
|4.28     |  | Form of Investor Warrant, dated November 6, 2007                                                |  | (13)    
|4.29     |  | Form of Underwriters Investor Warrant, dated November 6, 2007                                  |  | (13)    
|4.30     |  | Form of Underwriters Warrant, dated November 6, 2007                                           |  | (13)    
|10.1     |  | Supply and Distribution Agreement between Biopure and Dechra Veterinary Products                |  | (14)    
|31.1     |  | Certification of Zafiris G. Zafirelis pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 |  |         



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|         |  |                                                                                                                                                |  |         
|-------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------- |  | --------
|Exhibits |  | Description                                                                                                                                    |  | Location
|31.2     |  | Certification of David A. Butler pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                     |  |         
|32.1     |  | Certification of Zafiris G. Zafirelis pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 |  |         
|32.2     |  | Certification of David A. Butler pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002      |  |         



|(1) | Previously filed as an exhibit to the Companys report on Form 8-K dated October 2, 2007 and incorporated herein by reference thereto.
|--- | --------------------------------------------------------------------------------------------------------------------------------------

|(2) | Previously filed as an exhibit to the Companys report on Form 8-K dated December 14, 2007 and incorporated herein by reference thereto.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------

|(3) | Previously filed as an exhibit to the Companys report on Form 8-K dated April 26, 2002 and incorporated herein by reference thereto.
|--- | -------------------------------------------------------------------------------------------------------------------------------------

|(4) | Previously filed as an exhibit to the Companys quarterly report on Form 10-Q for the quarter ended April 30, 2003, filed June 16, 2003 and incorporated herein
by reference thereto.
|--- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(5) | Previously filed as an exhibit to the Companys report on Form 10-K for the year ended October 31, 2005, filed January 17, 2006 and incorporated herein by
reference thereto.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(6) | Previously filed as an exhibit to the Companys report on Form 8-K dated September 10, 2004 and incorporated herein by reference thereto.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------

|(7) | Previously filed as an exhibit to the Companys report on Form 8-K dated December 9, 2004 and incorporated herein by reference thereto.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------

|(8) | Previously filed as an exhibit to the Companys report on Form 8-K dated January 5, 2005 and incorporated herein by reference thereto.
|--- | --------------------------------------------------------------------------------------------------------------------------------------

|(9) | Previously filed as an exhibit to the Companys report on Form 8-K filed December 21, 2005 and incorporated herein by reference thereto.
|--- | ----------------------------------------------------------------------------------------------------------------------------------------

|(10) | Previously filed as an exhibit to the Companys report on Form 10-Q for the quarter ended July 31, 2006, filed September 11, 2006 and incorporated herein by
reference thereto.
|---- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(11) | Previously filed as an exhibit to the Companys report on Form 8-K dated August 23, 2006 and incorporated herein by reference thereto.
|---- | --------------------------------------------------------------------------------------------------------------------------------------

|(12) | Previously filed as an exhibit to the Companys registration statement on Form S-1/A (File No. 333-138049) and incorporated herein by reference thereto.
|---- | --------------------------------------------------------------------------------------------------------------------------------------------------------

|(13) | Previously filed as an exhibit to the Companys registration statement on Form S-1/A (File No. 333-146013) and incorporated herein by reference thereto.
|---- | --------------------------------------------------------------------------------------------------------------------------------------------------------

|(14) | Previously filed as an exhibit to the Companys report on Form 10-Q for the quarter ended April 30, 2008, filed June 16, 2008, and incorporated herein by reference thereto.
|---- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



28